{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54606", "l": "2-hydroxydecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + decanoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25891", "l": "dihydroxyacetone phosphate + iminosuccinate <=> H(+) + 2 H2O + phosphate + quinolinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264435", "l": "Dissociation of the COP1-p53 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60312", "l": "L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592251", "l": "Expression of mTERF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448702", "l": "Caspase-1 active tetramer formation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29343", "l": "L-aspartate(in) + succinate(out) = L-aspartate(out) + succinate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38112", "l": "glycerol + NADP(+) => H(+) + L-glyceraldehyde + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66793", "l": "N-methyl-D-dopa + O2 => (3R)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804724", "l": "MDM2 ubiquitinates phosphorylated MDM4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19284", "l": "(7S)-marmesin + O2 + reduced [NADPH--hemoprotein reductase] <=> acetone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + psoralen"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.116", "l": "\"Glucan 1,4-alpha-maltotriohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34519", "l": "N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + 3 UDP-N-acetyl-alpha-D-galactosamine = [alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + 3 H(+) + 3 UDP"}, {"i": "EC:2.4.1.292", "l": "\"GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49379", "l": "12-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 12,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334097", "l": "DNMT3B:DNMT3L methylates cytosine in DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15813", "l": "1H-imidazole + acetyl-CoA = CoA + N-acetylimidazole"}, {"i": "EC:2.3.1.2", "l": "\"Imidazole N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159826", "l": "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46778", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952823", "l": "p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952371", "l": "MDM2 binds RUNX3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404135", "l": "RBP4 binds atROL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350651", "l": "Caspase-mediated cleavage of MASK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000908", "l": "taurine dioxygenase activity"}, {"i": "MetaCyc:RXN0-299"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35261", "l": "7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + H(+) + phosphate => 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602466", "l": "Activation of MT-MMPs by FURIN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26465", "l": "6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine <=> 3-methyl-6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35152", "l": "4-hydroxy-3-nitrophenylacetaldehyde + H2O + NAD(+) => (3-nitro-4-oxidophenyl)acetate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050508", "l": "glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18168", "l": "biphenyl + H(+) + NADH + O2 <=> (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32244", "l": "alpha-D-ribose 1,5-bisphosphate => D-ribulose 1,5-bisphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58211", "l": "A + dihydroalstonine <=> AH2 + alstonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51324", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 = (8R)-hydroperoxy-(9E,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29814", "l": "ATP + H2O + thiamine(out) <=> ADP + H(+) + phosphate + thiamine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32544", "l": "(2E)-geranyl diphosphate + H2O => 1,8-cineole + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607721", "l": "Activation of NIK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62970", "l": "H(+) + NADPH + pyruvate => (R)-lactate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52645", "l": "D-xylono-1,4-lactone 5-phosphate + H2O => 5-phospho-D-xylonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879674", "l": "CD97 binds CD55 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50547", "l": "prostaglandin C2 <=> prostaglandin B2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018756", "l": "RHOH binds GTP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60071", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H(+) + 3 NADH + 3 O2 <=> 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 4 H2O + 3 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29163", "l": "2 H(+)(out) + 3 menaquinol-8(in) + nitrite(out) = 2 H2O(out) + 3 menaquinone-8(in) + NH4(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59310", "l": "D-galactonate + H(+) => D-galactono-1,5-lactone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673761", "l": "Autophosphorylation of membrane-tethered fusions of PDGFRA or PDGFRB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63674", "l": "H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+) => (S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36096", "l": "S-adenosyl-L-methionine + salicylate => methyl salicylate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "81.20444558259193", "identifiers": [{"i": "GO:0008373", "l": "sialyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65390", "l": "a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13769", "l": "glycerol + NAD(+) = dihydroxyacetone + H(+) + NADH"}, {"i": "EC:1.1.1.6", "l": "\"Glycerol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624668", "l": "CEBPA binds CDKN1A (p21) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027373", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27298", "l": "2-formylbenzoate + H2O + NAD(+) = 2 H(+) + NADH + phthalate"}, {"i": "EC:1.2.1.78", "l": "\"2-formylbenzoate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58132", "l": "A + ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] = AH2 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + serpentine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47877", "l": "ganglioside GD1b + H2O => ganglioside GM1 + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20019", "l": "5,10-methylenetetrahydromethanopterin + H(+) => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16437", "l": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+)"}, {"i": "RHEA:51220", "l": "1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)"}, {"i": "EC:2.5.1.18", "l": "\"Glutathione transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34339", "l": "22R-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (20R,22R)-20,22-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198611", "l": "AKT phosphorylates IKKalpha (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198714", "l": "ERK5 translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784598", "l": "NPPA(124-151) binds NPR1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14767", "l": "CO2 + excited coelenteramide h monoanion + H(+) + hnu => coelenterazine h + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389842", "l": "TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31726", "l": "liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2R,3S)-2,4',7-trihydroxyisoflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37640", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA => 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60619", "l": "N-dodecanoyl-heptadecasphing-4-enine-1-phosphoethanolamine <=> ethanolamine + N-dodecanoyl-heptadecasphing-4-enine-1,3-cyclic phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948136", "l": "ULK1 Translocates to the mitochondria (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004836", "l": "tyramine-beta hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21917", "l": "2 [Fe(III)cytochrome c550] + an aliphatic amine + H2O => 2 [Fe(II)cytochrome c550] + an aldehyde + 2 H(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2317332", "l": "PIP3 recruits AKT to the membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22565", "l": "a 2,3-saturated acyl-[ACP] + NADP(+) => a (2E)-enoyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163798", "l": "Furin cleaves pro-protein Z to protein Z (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912627", "l": "CBL ubiquitinates PI3K (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964773", "l": "OXGR1 binds 2OG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624272", "l": "MMPs cleave HB-EGF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40546", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0003700", "l": "DNA-binding transcription factor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046570", "l": "methylthioribulose 1-phosphate dehydratase activity"}, {"i": "MetaCyc:R145-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675948", "l": "TNFRSF6B binds TNFSF6,14,15 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205075", "l": "JNK phosphorylates BIM, BAD and other targets (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44948", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + H2O = 1-O-alkyl-2-acyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3858475", "l": "ppDVL recruits RAC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788867", "l": "FN3K phosphorylates ketosamines (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592398", "l": "Activation of proMMP8 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033919", "l": "glucan 1,3-alpha-glucosidase activity"}, {"i": "MetaCyc:3.2.1.84-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42214", "l": "a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31339", "l": "acetate + ATP + holo-[ACP] = acetyl-[ACP] + AMP + diphosphate"}, {"i": "EC:6.2.1.35", "l": "\"Acetate--[acyl-carrier protein] ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52417", "l": "3-dehydro-4-O-phospho-D-erythronate + H(+) => CO2 + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13072", "l": "ATP + ethanolamine <=> ADP + H(+) + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49402", "l": "phosphate + validoxylamine A => H2O + validoxylamine A 7'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21078", "l": "CO2 + succinate + uridine => 2'-deoxyuridine + 2-oxoglutarate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11745", "l": "H2O + thiamine triphosphate => H(+) + phosphate + thiamine diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018766", "l": "RHOU binds effectors at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39631", "l": "(2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H(+) + NADPH = (16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60214", "l": "CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111264", "l": "Addition of nucleotides between position +11 and +30 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912790", "l": "CBL binds CRK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25223", "l": "CO2 + taurine => H(+) + L-cysteate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380949", "l": "AMPK is dephosphorylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68595", "l": "ORC2 binds ORC3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54289", "l": "ATP + L-tyrosyl-[protein] => diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23208", "l": "acetyl-CoA + trans-glutaconate = (2E)-glutaconyl-CoA + acetate"}, {"i": "EC:2.8.3.12", "l": "\"Glutaconate CoA-transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.3.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093327", "l": "EPHA binds TIAM1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36154", "l": "(E)-cinnamyl alcohol + acetyl-CoA <=> (E)-cinnamyl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1606583", "l": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40929", "l": "(9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycerol + H(+) => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11549", "l": "5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O => 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41363", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine <=> H(+) + hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867344", "l": "OMA1 hydrolyses OPA1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56045", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61576", "l": "(4R,5R)-4,5-dihydroxycyclohex-2-ene-1-carbonyl-CoA + NADP(+) = (3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39499", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA = (2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28772", "l": "(2E)-hexadecenoyl-CoA => (9Z)-hexadecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55772", "l": "a jasmonate + an L-alpha-amino acid + ATP = a jasmonyl-L-amino acid + AMP + diphosphate + H(+)"}, {"i": "EC:6.3.2.52", "l": "\"Jasmonoyl--L-amino acid ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50249", "l": "ATP + D-ribose 5-phosphate + H(+) => ADP-D-ribose + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62883", "l": "9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + AH2 <=> (3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32750", "l": "ethanolamine(in) <=> ethanolamine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28946", "l": "glycine betaine(in) <=> glycine betaine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66770", "l": "ADP + coproporphyrin I(out) + H(+) + phosphate => ATP + coproporphyrin I(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5662466", "l": "XYLB phosphorylates D-xylulose (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60737", "l": "(2E,6E)-farnesal + H2O + NADP(+) => (2E,6E)-farnesoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20805", "l": "2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) => H(+) + hydrogencarbonate + NADH + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13352", "l": "jasmonate + S-adenosyl-L-methionine <=> methyl (-)-jasmonate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21548", "l": "H2O + N(6)-acetyl-L-lysyl-[alpha-tubulin] = acetate + L-lysyl-[alpha-tubulin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11863", "l": "ATP + L-histidyl-[protein] <=> ADP + H(+) + N(tele)-phospho-L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1006143", "l": "CD46 binds C3b (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31785", "l": "diphosphate + tuberculosinol => H2O + tuberculosinyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201783", "l": "Inactive catalytic PP2B is activated by the binding of calmodulin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948027", "l": "RNASEs bind bacterial phospholipids (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707516", "l": "FeHM dissociates from MetHb (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604752", "l": "Initial activation of proMMP13 by MMP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849900", "l": "SALMs1-3 bind each other in cis interactions (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39981", "l": "H(+) + N-methylpavine + S-adenosyl-L-homocysteine => (+-)-pavine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51347", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate <=> 8,9-epoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14699", "l": "(2E,6E)-farnesal + H(+) + NADPH => (2E,6E)-farnesol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17230", "l": "acetyl-CoA + an aliphatic alcohol => an acetyl ester + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070290", "l": "N-acylphosphatidylethanolamine-specific phospholipase D activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30684", "l": "H2O + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N-acetyl-D-mannosamine + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47545", "l": "trans-4-hydroxy-L-proline betaine => cis-4-hydroxy-D-proline betaine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-481007", "l": "Exocytosis of platelet alpha granule contents (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001853", "l": "complement component C3dg binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57759", "l": "2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH <=> C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399952", "l": "Phosphorylation of LIMK-1 by PAK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32853", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37685", "l": "1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10168", "l": "15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin] = biliverdin IXalpha + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]"}, {"i": "EC:1.3.7.2", "l": "\"15,16-dihydrobiliverdin:ferredoxin oxidoreductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399978", "l": "Protein kinase C, alpha type phosphorylates MARCKS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-163310", "l": "TFAM binds to mitochondrial promoters (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61304", "l": "N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose = H(+) + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21893", "l": "D-arabinose + NADP(+) => D-arabinono-1,4-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046557", "l": "glucan endo-1,6-beta-glucosidase activity"}, {"i": "MetaCyc:3.2.1.75-RXN"}, {"i": "EC:3.2.1.75", "l": "\"Glucan endo-1,6-beta-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56843", "l": "5-amino-2-hydroxybenzoate + O2 <=> (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218812", "l": "FYN phosphorylates PAK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432520", "l": "CLK:CYC heterodimer binds to cwo gene and activates transcription (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53897", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc-R + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696958", "l": "USP44 deubiquitinates CDC20 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9724290", "l": "GNRHR2 binds GNRH1,2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35659", "l": "an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + GDP-alpha-D-mannose = GDP + H(+) + mannosylinositol phosphorylphytoceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56126", "l": "AH2 + diphosphate + nonaflavuxanthin => A + all-trans-lycopene + dimethylallyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029273", "l": "PI3K binds to p-6Y-SYK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013157", "l": "CDC42 binds effectors at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48556", "l": "4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) = 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate"}, {"i": "EC:2.4.2.54", "l": "\"Beta-ribofuranosylphenol 5'-phosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54065", "l": "(2E,6E)-farnesyl diphosphate + H2O => 10-epi-cubebol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29206", "l": "dimethyl sulfoxide + menaquinol-8 <=> dimethyl sulfide + H2O + menaquinone-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674095", "l": "PDGFRs bind type II TKI (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38862", "l": "beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP-alpha-D-glucose <=> bis(beta-D-gentiobiosyl) crocetin + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36524", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA => (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950423", "l": "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67156", "l": "1-O-(1Z-hexadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11604", "l": "[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA = [(2->8)-O(7),N-diacetyl-alpha-D-neuraminosyl](n) + n CoA"}, {"i": "RHEA:11608", "l": "[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA = [(2->8)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA"}, {"i": "EC:2.3.1.136", "l": "\"Polysialic-acid O-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034797", "l": "fosfomycin 2-glutathione ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163798", "l": "Furin cleaves pro-protein Z to protein Z (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56757", "l": "5 H(+) + 3 O2 + obtusifoliol + 6 reduced [2Fe-2S]-[ferredoxin] => 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59781", "l": "L-histidine + S-adenosyl-L-methionine => (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62433", "l": "a uridine in tRNA + S-adenosyl-L-methionine => a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35341", "l": "3-oxoeicosanoyl-CoA + H(+) + NADPH => 3-hydroxyicosanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16025", "l": "an anthocyanidin 3-O-beta-D-glucoside + malonyl-CoA = an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + CoA"}, {"i": "EC:2.3.1.171", "l": "\"Anthocyanin 6''-O-malonyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004459", "l": "L-lactate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249378", "l": "STING recruits TBK1 and STAT6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001094", "l": "TFIID-class transcription factor complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51036", "l": "2 2-iminio-3-(indol-3-yl)propanoate + H2O2 = 2 H2O + indole-3-pyruvate imine dimer"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784598", "l": "NPPA(124-151) binds NPR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032427", "l": "GBD domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507719", "l": "p62:MEKK3 binds to TRAF6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35829", "l": "spermidine + urea => H2O + N(1)-aminopropylagmatine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1226014", "l": "Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48889", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione => (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36847", "l": "FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)"}, {"i": "EC:2.7.1.180", "l": "\"FAD:protein FMN transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34131", "l": "neryl diphosphate + olivetolate = cannabinerolate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25929", "l": "3-methylquinoline + A + H2O => 3-methylquinolin-2(1H)-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2250301", "l": "Formation of lysyl-pyrrole cross-links (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68688", "l": "CDC6 association with ORC:origin complexes mediated by MCM8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047424", "l": "methylenediurea deaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176879", "l": "apolipoprotein(a) + LDL => Lp(a) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2160915", "l": "Receptor-mediated uptake of HA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61620", "l": "[(1->2)-beta-D-mannosyl](n) + GDP-alpha-D-mannose = [(1->2)-beta-D-mannosyl](n+1) + GDP + H(+)"}, {"i": "EC:2.4.1.374", "l": "\"Beta-1,2-mannooligosaccharide synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65123", "l": "H2O + S-[(2E,6E,10E)-geranylgeranyl]-L-glutathione <=> L-glutamate + S-[(2E,6E,10E)-geranylgeranyl]-L-cysteinylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.176", "l": "\"Propanoyl-CoA C-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.76", "l": "\"Flavastacin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38147", "l": "carbon disulfide + H2O = carbonyl sulfide + H(+) + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197562", "l": "NOTCH2 stimulates HES1 transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46495", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(in) <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50165", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32666", "l": "5-guanidino-2-oxopentanoate + S-adenosyl-L-methionine <=> 5-guanidino-3-methyl-2-oxopentanoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66944", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + soppiline B = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + soppiline C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63175", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA <=> (25R)-3-oxocholest-4-en-26-oyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14749", "l": "1-hydroxy-2-naphthoate + O2 = (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(+)"}, {"i": "EC:1.13.11.38", "l": "\"1-hydroxy-2-naphthoate 1,2-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31396", "l": "15-cis-4,4'-diapophytoene + FAD + H(+) => all-trans-4,4'-diapophytofluene + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850997", "l": "TRIM27 binds PTEN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66114", "l": "(2S)-2-aminobutanoate + 3-(4-hydroxyphenyl)pyruvate => 2-oxobutanoate + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37922", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16863", "l": "(7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate => (S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27534", "l": "(2E,6E)-farnesyl diphosphate + H2O = (3R,6E)-nerolidol + diphosphate"}, {"i": "EC:4.2.3.49", "l": "\"(3R,6E)-nerolidol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4090288", "l": "PIAS1,3 SUMOylate MBD1 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419451", "l": "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004309", "l": "exopolyphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.24.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801101", "l": "RABGGTA binds RABGGTB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.22", "l": "\"Endothiapepsin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801675", "l": "PLK2 phosphorylates NPM1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17031", "l": "allantoate + H(+) => (S)-allantoin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-114553", "l": "Activation of conventional Protein Kinase C (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43801", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55611", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43438", "l": "coproporphyrin III + 3 H2O2 => coproporphyrinogen III + 3 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27426", "l": "(2E,6E)-farnesyl diphosphate => (E)-beta-farnesene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712204", "l": "ANO2:Ca2+ translocates Cl- from the cytosol to the extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950218", "l": "Expression of Moesin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858270", "l": "HILPDA binds lipid droplets (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420591", "l": "Nectin-2:Nectin 3 trans heterodimer interaction (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51783", "l": "4-prenylphlormethylbutanophenone + dimethylallyl diphosphate <=> deoxyadlupulone + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57602", "l": "2 [Fe(III)-cytochrome b5] + a 1-[(17Z)-hexacos-17-enoyl]-2-acyl-phosphoglycerolipid + 2 H2O => 2 [Fe(II)-cytochrome b5] + a 1-hexacosanoyl-2-acyl-phosphoglycerolipid + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55840", "l": "calcidiol + UDP-alpha-D-glucuronate = calcidiol 25-O-(beta-D-glucuronide) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665659", "l": "RAC1:GTP:FMNL1 binds profilin:G-actin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19538", "l": "D-mannitol 1-phosphate + H2O => D-mannitol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001761", "l": "beta-alanine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64703", "l": "1-phenylethanol + NAD(+) <=> acetophenone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047011", "l": "2-dehydropantolactone reductase (A-specific) activity"}, {"i": "RHEA:18981", "l": "(R)-pantolactone + NADP(+) = 2-dehydropantolactone + H(+) + NADPH"}, {"i": "MetaCyc:1.1.1.168-RXN"}, {"i": "EC:1.1.1.168", "l": "\"2-dehydropantolactone reductase (Re-specific)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21446", "l": "H(+) + NADH + trans-2-coumarate => 3-(2-hydroxyphenyl)propanoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0031776", "l": "melanin-concentrating hormone receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49460", "l": "(2Z,4E)-2-aminomuconate + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH4(+)"}, {"i": "EC:3.5.99.11", "l": "\"2-aminomuconate deaminase (2-hydroxymuconate-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399711", "l": "Activation of Ca impermeable AMPA receptors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50985", "l": "prostaglandin E2(out) => prostaglandin E2(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173631", "l": "Activation of C1s (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32968", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O => a fatty acid + H(+) + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44913", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH => (3E)-hexenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22851", "l": "(3S)-hydroxyoctanedioyl-CoA + NAD(+) <=> 3-oxooctanedioyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27607", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26070", "l": "CoA + H(+) + phosphinomethylmalate => 3-(hydrohydroxyphosphoryl)pyruvate + acetyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58244", "l": "H2O + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] = ADP-D-ribose + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.32"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9630923", "l": "NFkB inhibitor binds NFkB complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983156", "l": "Polyubiquitination of substrate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421831", "l": "trans-Golgi Network Coat Assembly (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39405", "l": "(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+) => (2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58591", "l": "dihydroprecondylocarpine acetate + NADPH <=> (+)-vincadifformine + acetate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43097", "l": "guanosine(2535) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(2535) in 23S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140295", "l": "pathogen-derived receptor ligand activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229343", "l": "AXIN is phosphorylated in the destruction complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13488", "l": "2-oxoglutarate + S-(4-bromophenyl)-L-cysteine <=> 3-((4-bromophenyl)sulfanyl)-2-oxopropanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24016", "l": "16-epivellosimine + acetyl-CoA = CoA + vinorine"}, {"i": "EC:2.3.1.160", "l": "\"Vinorine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49073", "l": "dibenzothiophene + 2 FMNH2 + 2 O2 => dibenzothiophene 5,5-dioxide + 2 FMN + 2 H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514831", "l": "Fibrillin-1 degradation by MMP14 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66269", "l": "CoA + nonanoyl-AMP => AMP + H(+) + nonanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805399", "l": "TAF1 phosphorylates TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53019", "l": "chlorohydroquinone + 2 glutathione <=> chloride + glutathione disulfide + H(+) + hydroquinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54423", "l": "3',3'-c-di-AMP + H2O <=> 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444433", "l": "Cho transports from the extracellular space to the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66784", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(out) = 6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787447", "l": "TRMU (MTO2, MTU1) transfers a sulfur atom to 5-taurinomethyluridine-34 in tRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40159", "l": "H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose = NAD(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.51"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41412", "l": "1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088134", "l": "PLK1 phosphorylates FOXM1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18423", "l": "chloramphenicol 3-acetate + CoA => acetyl-CoA + chloramphenicol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-350901", "l": "Iodide is organified (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31683", "l": "prosolanapyrone III = (-)-solanapyrone A"}, {"i": "EC:5.5.1.20", "l": "\"Prosolanapyrone-III cycloisomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851988", "l": "BTN2A2 binds T cell surface (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047237", "l": "glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"}, {"i": "RHEA:23464", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}, {"i": "EC:2.4.1.174", "l": "\"Glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72647", "l": "Cap-bound mRNA is activated by helicases  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19975", "l": "H(+) + S-methyl-5'-thioadenosine + spermine => S-adenosyl 3-(methylsulfanyl)propylamine + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419003", "l": "Interaction of Nectins with Afadin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044610", "l": "FMN transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56327", "l": "(DNA)-(deoxyribonucleoside 5'-methylphosphotriester) + L-cysteinyl-[protein] <=> (DNA)-(deoxyribonucleoside 5'-phosphate) + H(+) + S-methyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106332", "l": "ds/ssDNA junction-specific dsDNA endonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44008", "l": "2-methyl-branched fatty aldehyde + H2O + NAD(+) = 2-methyl fatty acid + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672948", "l": "MARK3 phosphorylates KSR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24748", "l": "2-aminobut-2-enoate + methanethiol => L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65290", "l": "CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamine => CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36526", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA <=> (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29140", "l": "2 H(+)(in) + menaquinol-8 + nitrate => 2 H(+)(out) + H2O + menaquinone-8 + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047597", "l": "6-oxocineole dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33289", "l": "1-pyrroline + AH2 + propane-1,3-diamine => A + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39006", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> a 1-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31041", "l": "(2E)-dodecenoyl-CoA + FADH2 => dodecanoyl-CoA + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24635", "l": "2 H2O + 3 NADP(+) + NH4(+) <=> 5 H(+) + 3 NADPH + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43491", "l": "7(1)-hydroxychlorophyll a + NAD(+) <=> chlorophyll b + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57129", "l": "H2O + 2 oxidized [azurin] + tyramine => (4-hydroxyphenyl)acetaldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.20", "l": "\"DNA-3-methyladenine glycosylase I\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54000", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32891", "l": "(1S,5S)-alpha-pinene + H(+) + NADH + O2 = alpha-pinene oxide + H2O + NAD(+)"}, {"i": "EC:1.14.13.155", "l": "\"Alpha-pinene monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38934", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340226", "l": "CYGB dioxygenates NO (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011145", "l": "LHX2,(LHX9) binds the ROBO3 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5604929", "l": "Activated protein C binds Protein S (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654422", "l": "Activated FGFR4 binds FRS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31977", "l": "7beta-hydroxytaxusin + H2O + NADP(+) => H(+) + NADPH + O2 + taxusin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19575", "l": "[phosphate](n+1) + ADP => [phosphate](n) + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37990", "l": "delta-tocopherol <=> 2-methyl-6-phytyl-1,4-benzene-1,4-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634429", "l": "CSF3R gene expression is enhanced by SPI1 (PU.1), CEBPA, and DEK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46151", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O <=> a 2'-deoxyribonucleoside + H(+) + triphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047408", "l": "alkenylglycerophosphocholine hydrolase activity"}, {"i": "RHEA:22544", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine"}, {"i": "EC:3.3.2.2", "l": "\"Lysoplasmalogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646383", "l": "Dynein motors transport misfolded proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47783", "l": "a cytidine in 25S rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in 25S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849900", "l": "SALMs1-3 bind each other in cis interactions (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420688", "l": "GABAB heterodimeric receptor binds GABA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12104", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8-dihydrofolate + dTMP"}, {"i": "EC:2.1.1.45", "l": "\"Thymidylate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38402", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O <=> (9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46251", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 <=> (14Z)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.80"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209376", "l": "SPN27A binds to and inhibits EA protease activity (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39462", "l": "(7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080045", "l": "quercetin 3'-O-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56986", "l": "(6E)-nerolidol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63276", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 = a 1-acyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34293", "l": "2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP => 2',4,4',6'-tetrahydroxychalcone + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047686", "l": "arylsulfate sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22495", "l": "H2O + N-formimidoyl-L-glutamate <=> formamide + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41328", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(8Z,10E,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.56", "l": "\"Lipopolysaccharide N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65403", "l": "butan-1-ol + butanoyl-CoA <=> butyl butanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9656947", "l": "OGG1beta translocates to mitochondria (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27792", "l": "3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP(+) => 2-all-trans-octaprenylphenol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21975", "l": "precorrin-1 + S-adenosyl-L-methionine <=> precorrin-2 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45430", "l": "H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + sn-glycerol 3-phosphate => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694373", "l": "Unphosphorylated nucleoprotein translocates to the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37166", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30097", "l": "a menaquinol + oxaloacetate => (S)-malate + a menaquinone"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050206", "l": "oximinotransferase activity"}, {"i": "MetaCyc:OXIMINOTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61514", "l": "malvidin 3-O-beta-D-glucoside + UDP => malvidin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641147", "l": "DACT1 binds DVL2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37532", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53911", "l": "(2E)-butenoyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-(2E)-butenoyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31461", "l": "2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate => 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209828", "l": "Tryptophan is hydroxylated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18897", "l": "3,3',5'-triiodo-L-thyronine + A + H(+) + iodide = AH2 + L-thyroxine"}, {"i": "EC:1.21.99.3", "l": "\"Thyroxine 5-deiodinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23382", "l": "H(+) + N,N'-diacetylchitobiosyl diphosphodolichol + UDP => N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66514", "l": "1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 1-acyl-2-(9Z,12Z-octadecadienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35472", "l": "(+)-6a-hydroxymaackiain + S-adenosyl-L-methionine => (+)-pisatin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66178", "l": "ADP + H(+) + phosphate + taurochenodeoxycholate 3-sulfate(out) => ATP + H2O + taurochenodeoxycholate 3-sulfate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047055", "l": "salutaridine synthase activity"}, {"i": "RHEA:17713", "l": "(R)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + salutaridine"}, {"i": "EC:1.14.19.67", "l": "\"Salutaridine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787820", "l": "IL34 dimer binds CSF1R (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665009", "l": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15191", "l": "2 [Fe(II)cytochrome c553] + CO2 + H(+) => 2 [Fe(III)cytochrome c553] + formate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25630", "l": "myricetin + S-adenosyl-L-methionine => H(+) + laricitrin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15445", "l": "H(+) + H2O + O-carbamoyl-L-serine = CO2 + 2 NH4(+) + pyruvate"}, {"i": "EC:4.3.1.13", "l": "\"Carbamoyl-serine ammonia-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20887", "l": "H2O + L-serine + NAD(+) <=> 3-hydroxypyruvate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016314", "l": "phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018712", "l": "3-hydroxybutyryl-CoA thiolase activity"}, {"i": "MetaCyc:R7-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004705", "l": "JUN kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3700981", "l": "TP53 family members bind the BAX promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61236", "l": "H2O + L-methionine + O2 = 4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111970", "l": "PKC phosphorylates GRK2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56115", "l": "2-all-trans-nonaprenylphenol + H(+) + NADPH + O2 <=> 3-(all-trans-nonaprenyl)benzene-1,2-diol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449115", "l": "IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34243", "l": "GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide"}, {"i": "EC:2.7.7.77", "l": "\"Molybdenum cofactor guanylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "75.324974028080362", "identifiers": [{"i": "GO:0016837", "l": "carbon-oxygen lyase activity, acting on polysaccharides"}, {"i": "EC:4.2.2.-", "l": "\"Acting on polysaccharides\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27624", "l": "7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate => geranylgeranyl diphosphate + 7 isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707505", "l": "Hemes bind to CLEC1B dimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209358", "l": "Phosphorylated AP-1, Phospho JRA:Phospho KAY binds to a target gene and activates transcription (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9724099", "l": "ALK mutants:p-3Y SHC binds GRB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2002428", "l": "Removal of fibrillar collagen N-propeptides (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047147", "l": "trimethylsulfonium-tetrahydrofolate N-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1362416", "l": "Frataxin binds iron (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59780", "l": "L-histidine + S-adenosyl-L-methionine = (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981093", "l": "IL12 bound to IL12R internalises (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046025", "l": "precorrin-6Y C5,15-methyltransferase (decarboxylating) activity"}, {"i": "MetaCyc:2.1.1.132-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12421", "l": "ATP + D-tagatofuranose 6-phosphate => ADP + D-tagatofuranose 1,6-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25474", "l": "diphosphate + gamma-himachalene => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12302", "l": "3-[(3S)-3-amino-3-carboxypropyl]uridine(47) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine => S-adenosyl-L-methionine + uridine(47) in tRNA(Phe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847968", "l": "PTEN binds FRK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38672", "l": "sphinganine 1-phosphate(in) => sphinganine 1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30749", "l": "(2E)-hexadecenoyl-CoA + FADH2 => FAD + H(+) + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65581", "l": "H2O + TTP => H(+) + phosphate + TDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.49"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033520", "l": "TYSND1 cleaves TYSND1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177284", "l": "PKA phosphorylates PDE4B (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68849", "l": "Mcm2-7 associates with the Cdt1:CDC6:ORC:origin complex, forming the pre-replicative complex (preRC) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32728", "l": "a very-long-chain acyl-CoA + H(+) + malonyl-CoA => a very-long-chain 3-oxoacyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786070", "l": "IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38207", "l": "19-oxo-androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = estrone + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37163", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38140", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031530", "l": "gonadotropin-releasing hormone receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "71.944304668973928", "identifiers": [{"i": "GO:0030246", "l": "carbohydrate binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009012", "l": "aminoglycoside 3''-adenylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.2.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783530", "l": "gp130:JAKs bind CNTFR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61758", "l": "H(+) + rebaudioside A + UDP => stevioside + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847968", "l": "PTEN binds FRK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26305", "l": "2-aminophenol + O2 = 2-aminomuconate 6-semialdehyde"}, {"i": "EC:1.13.11.74", "l": "\"2-aminophenol 1,6-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44269", "l": "3 H(+) + hexadecanoyl-CoA + 3 malonyl-CoA => 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004508", "l": "steroid 17-alpha-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607756", "l": "TRAF6 oligomer autoubiquitinates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56311", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] <=> 1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28613", "l": "H2O + XTP <=> diphosphate + H(+) + XMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086200", "l": "Dentin matrix protein 1 binds integrin alphaVbeta3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28537", "l": "dTTP + H2O <=> diphosphate + dTMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375133", "l": "Basigin binds Mannose-carrying cell recognition molecules (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46096", "l": "3-phenylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4 CO2 + 4 CoA + dihydropinosylvin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46897", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) => a 1,2-diacyl-sn-glycerol + lipid A hexaacyl 1-(2-aminoethyl diphosphate)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50811", "l": "glutathione + prostaglandin J2 <=> prostaglandin J2-S-(S)-glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30916", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O => a fatty acid + beta-D-glucosyl-(1<->1)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52980", "l": "a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] = 7-oxoheptanoyl-[ACP] + a fatty aldehyde + H(+) + 2 H2O + oxidized [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031852", "l": "mu-type opioid receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57299", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O <=> a 2'-deoxyguanosine in DNA + glycolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50139", "l": "ethyl (9Z)-octadecenoate + H2O <=> (9Z)-octadecenoate + ethanol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31547", "l": "2 (2E,6E)-farnesyl diphosphate = 15-cis-4,4'-diapophytoene + 2 diphosphate"}, {"i": "EC:2.5.1.96", "l": "\"4,4'-diapophytoene synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0018635", "l": "(R)-limonene 1,2-monooxygenase activity"}, {"i": "KEGG.REACTION:R09393"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-378952", "l": "Thyrotropin is a heterodimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9727349", "l": "XDH dehydrogenates xanthine to form urate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.99.2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140474", "l": "mitochondrion-endoplasmic reticulum membrane tether activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983259", "l": "Kinesins move along microtubules consuming ATP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729260", "l": "GSK3 phosphorylates nucleoprotein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1369052", "l": "ABCAs mediate lipid influx (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52324", "l": "2 L-arginine + 4 O2 + 3 reduced [flavodoxin] = 5 H(+) + 4 H2O + 2 L-citrulline + 2 nitric oxide + 3 oxidized [flavodoxin]"}, {"i": "EC:1.14.14.47", "l": "\"Nitric-oxide synthase (flavodoxin)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44594", "l": "2-methoxy-6-(all-trans-heptaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-heptaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31901", "l": "H(+) + H2O + indolin-2-one + oxidized [NADPH--hemoprotein reductase] => indole + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55232", "l": "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 [Fe(II)-cytochrome b5] + H(+) + O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 2 [Fe(III)-cytochrome b561] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36880", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + AH2 + O2 => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49179", "l": "12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine <=> 12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.98.-", "l": "\"With other, known, acceptors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45699", "l": "N-(acetyl)-sphing-4-enine-1-phosphate(in) <=> N-(acetyl)-sphing-4-enine-1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55544", "l": "L-lysyl-[citrate synthase] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35729", "l": "1-dodecanoyl-sn-glycerol 3-phosphate + CoA => dodecanoyl-CoA + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672011", "l": "p-AMPK:AMP binds the ULK complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37764", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA => 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37058", "l": "3-(4-hydroxyphenyl)pyruvate + dimethylallyl diphosphate <=> 3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209061", "l": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19434", "l": "ATP + D-gluconate => 6-phospho-D-gluconate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203973", "l": "Vesicle budding (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371422", "l": "ATP hydrolysis by HSP70 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24633", "l": "2 H2O + 3 NADP(+) + NH4(+) => 5 H(+) + 3 NADPH + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47501", "l": "cholate + NADP(+) => 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39624", "l": "3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45080", "l": "3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine = ADP + dapdiamide E + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42682", "l": "2 H2O + 2 hercynylselenocysteine => 2 hercynine + 2 L-selenocysteine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29451", "l": "H2O + phosphonate = H2 + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617064", "l": "SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034076", "l": "cucurbitadienol synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158795", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653957", "l": "Rag dimer formation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007539", "l": "CHEK1 phosphorylates E2F6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686587", "l": "ABL1 phosphorylates RAD52 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444047", "l": "Receptor FFAR3 binds carboxylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29519", "l": "alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)"}, {"i": "EC:2.4.1.257", "l": "\"GDP-Man:Man(2)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031840", "l": "type 2 neuromedin U receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013110", "l": "RHOC binds effectors at the plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34250", "l": "1-deoxymethyl-sphinganine + NADP(+) <=> 1-deoxymethyl-3-dehydrosphinganine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20994", "l": "16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine => 16-hydroxytabersonine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44069", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54949", "l": "(3R)-hydroxy-(5Z)-dodecenoyl-[ACP] => (2E,5Z)-dodecadienoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20472", "l": "H2O + IMP <=> D-ribose 5-phosphate + hypoxanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50619", "l": "NADP(+) + nonan-2-one <=> (3E)-nonen-2-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20550", "l": "2 [Fe(III)cytochrome c] + 2 thiosulfate => 2 [Fe(II)cytochrome c] + 2 H(+) + tetrathionate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72095", "l": "Internal Methylation of mRNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948757", "l": "AKT phosphorylates MKRN1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28180", "l": "colnelenate + H2O => (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373706", "l": "Contactin-1 (CNTN1) binds NOTCH1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416690", "l": "SEMA4A binds to PLXND1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28032", "l": "[thioredoxin]-dithiol + GDP => [thioredoxin]-disulfide + dGDP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62983", "l": "(9Z)-hexadecenamide + H2O <=> (9Z)-hexadecenoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60398", "l": "Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730847", "l": "Hydrolysis of PIP2 by PLCG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007686", "l": "RUNX2 gene expression from distal (P1) promoter is inhibited by NKX3-2, MSX2 and RUNX2-P1, and stimulated by DLX5,(DLX6) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3791319", "l": "NID1 degradation by MMP19 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429767", "l": "Passive I- efflux mediated by SMCT1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31696", "l": "(9Z,12Z)-octadecadienoate + O2 => (8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24660", "l": "H(+) + L-arginine + NADPH + O2 = H2O + N(omega)-hydroxy-L-arginine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31335", "l": "CTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin cytosine dinucleotide"}, {"i": "EC:2.7.7.76", "l": "\"Molybdenum cofactor cytidylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34407", "l": "3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate"}, {"i": "EC:2.7.7.84", "l": "\"2'-5' oligoadenylate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624956", "l": "PDE6D binds INPP5E (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050809", "l": "diazepam binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64715", "l": "1-propanol + NADP(+) <=> H(+) + NADPH + propanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54663", "l": "an aromatic (S)-hydroxynitrile <=> an aromatic aldehyde + hydrogen cyanide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41714", "l": "a 2-acyl-sn-glycerol 3-phosphate + choline + H(+) => a 2-acyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13420", "l": "5,12-dihydroxanthommatin + NAD(+) <=> H(+) + NADH + xanthommatin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.18"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22228", "l": "H(+) + NADH + presqualene diphosphate = diphosphate + NAD(+) + squalene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35468", "l": "(6S)-5,6,7,8-tetrahydrofolate + S,S-dimethyl-beta-propiothetin => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-(methylsulfanyl)propanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30984", "l": "H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] => beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350769", "l": "trans-Golgi Network Coat Activation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28962", "l": "D-xylose(in) + H(+)(in) <=> D-xylose(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39343", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA = (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783670", "l": "CRLF1 binds CLCF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18228", "l": "[N-(6-aminohexanoyl)](n) + H2O <=> 6-aminohexanoate + [N-(6-aminohexanoyl)](n-1)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23263", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NAD(+) <=> 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32278", "l": "4-(phosphooxy)-L-threonine + NAD(+) <=> 3-amino-2-oxopropyl phosphate + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20342", "l": "sn-glycerol 3-phosphate + UDP-alpha-D-galactose => 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39442", "l": "(3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA <=> (2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019797", "l": "procollagen-proline 3-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44296", "l": "2 H(+) + hexadecanoyl-CoA + malonyl-CoA + methylmalonyl-CoA = 4-hydroxy-5-methyl-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938389", "l": "RUNX1:CBFB binds the LGALS3 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53538", "l": "(13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate => (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730835", "l": "Autophosphorylation of PKC-theta (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59867", "l": "(indol-3-yl)butanoate + ATP + L-glutamine <=> (indol-3-yl)butanoyl-L-glutamine + AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19307", "l": "2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA => 3-hydroxybenzoyl-CoA + 2 H(+) + 3 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19058", "l": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione => a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51873", "l": "dimethylallyl diphosphate + umbelliferone => diphosphate + osthenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17882", "l": "H2O + N-sulfo-D-glucosamine => D-glucosamine + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29347", "l": "2 H(+)(in) + orotate(in) = 2 H(+)(out) + orotate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63743", "l": "2-phenylacetaldehyde + H(+) + NADH <=> 2-phenylethanol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696274", "l": "RND1 binds GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1170539", "l": "Prolactin receptor is internalized (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43682", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "66.254021125069187", "identifiers": [{"i": "GO:0016620", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28628", "l": "O2 + reduced [NADPH--hemoprotein reductase] + solavetivol => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + solavetivone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730904", "l": "Auto-ubiquitination of TRAF6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35316", "l": "H(+) + hexadecanoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909726", "l": "Phosphorylation of STAT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205319", "l": "Interaction of APS and p-KIT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705729", "l": "SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9649735", "l": "Intrinsic nucleotide exchange on RAS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168644", "l": "CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60608", "l": "1-tetradecanoyl-sn-glycero-3-phosphoethanolamine = 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798044", "l": "BTG2 binds CCR4-NOT complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299338", "l": "Activation of TRESK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0050543", "l": "icosatetraenoic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680408", "l": "BRD4 binds fedratinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9615348", "l": "AGT(34-41) binds to AGTR2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35301", "l": "3-oxooctadecanoyl-CoA + H(+) + NADPH => 3-hydroxyoctadecanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75081", "l": "Formation of AT-AC B Complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-873917", "l": "Translocation of STAT1 dimer to nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004411", "l": "homogentisate 1,2-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700175", "l": "Active ALK phosphorylates SHC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69068", "l": "RFC dissociates after sliding clamp formation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18712", "l": "A + H2O + taurine <=> AH2 + NH4(+) + sulfoacetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102612", "l": "syn-pimaradiene 6beta-hydroxylase activity"}, {"i": "MetaCyc:RXN-15452"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45693", "l": "N-(octanoyl)-sphing-4-enine-1-phosphate(in) => N-(octanoyl)-sphing-4-enine-1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114352", "l": "Sequestration of tBID by BCL-2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141367", "l": "Myristoylation of tBID by NMT1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14283", "l": "2 [Fe(II)cytochrome c] + 2 H(+) + sulfate => 2 [Fe(III)cytochrome c] + H2O + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45312", "l": "NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin H2"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0044389", "l": "ubiquitin-like protein ligase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27625", "l": "geranylgeranyl diphosphate + 7 isopentenyl diphosphate <=> 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24190", "l": "1,2-dihydroxydibenzothiophene + H(+) + NADH => cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018804", "l": "RAC3 GEFs activate RAC3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0070643", "l": "vitamin D 25-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140545", "l": "protein disaggregase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21306", "l": "ent-kaur-16-en-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-ol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39749", "l": "cholesterol(out) => cholesterol(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465924", "l": "OPN1LW binds 11cRAL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56098", "l": "[protein]-C-terminal Gly-Gly-AMP + diphosphate => [protein]-C-terminal Gly-Gly + ATP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.25", "l": "\"4-alpha-glucanotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41000", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O => 1-tetradecanoyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638007", "l": "RP2 activates the GTPase activity of ARL3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3858489", "l": "ppDVL binds DAAM1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806629", "l": "Formation of tonofilament bundles (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10375", "l": "CoA + NAD(+) + phenylglyoxylate <=> benzoyl-CoA + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34660", "l": "C30 botryococcene + S-adenosyl-L-methionine => 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003998", "l": "acylphosphatase activity"}, {"i": "RHEA:14965", "l": "an acyl phosphate + H2O = a carboxylate + H(+) + phosphate"}, {"i": "EC:3.6.1.7", "l": "\"Acylphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50759", "l": "NADP(+) + reduced [flavodoxin] <=> 2 H(+) + NADPH + oxidized [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35570", "l": "H2O + N-(9Z,12Z-octadecadienoyl)-ethanolamine <=> (9Z,12Z)-octadecadienoate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5252133", "l": "ATP6AP1 binds V-ATPase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36068", "l": "Co-precorrin-6B + S-adenosyl-L-methionine => Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218821", "l": "PDK1 phosphorylates PKC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60414", "l": "[N-(2,3-dihydroxybenzoyl)-L-seryl]2-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine + H(+) => H2O + monoglucosyl-enterobactin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72124", "l": "Formation of the Spliceosomal A Complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050162", "l": "oxalate oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15430", "l": "heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800380", "l": "PTPRD binds IL1RAP-1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35910", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21010", "l": "diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH => diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48238", "l": "1,3,5-trihydroxybenzene + 2,4-diacetylphloroglucinol + H(+) => 2 2-acetylphloroglucinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66609", "l": "(tRNA)-3'-end (ribonucleoside 5'-phosphate)-(guanosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(adenosine 5'-phosphate) + H2O => GpCpCpA + H(+) + tRNA 3'-end (3'-phosphooxy-ribonucleotide)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58336", "l": "a 4-hydroxynonen-1-ol + NADP(+) = a 4-hydroxynonenal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730856", "l": "Autophosphorylation of PAK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211340", "l": "Anthrax lef cleaves target cell MAP2K1 (MEK1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015379", "l": "potassium:chloride symporter activity"}, {"i": "REACT:R-HSA-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Homo sapiens)"}, {"i": "REACT:R-HSA-5623806", "l": "Defective SLC12A6 does not cotransport K+, Cl- from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863858", "l": "SEC22B, CALR, STX4, TAP and TAPBP bind (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014296", "l": "RAC2 GEFs activate RAC2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14414", "l": "biphenyl-2,3-diol + O2 => 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944223", "l": "Association of procollagen type V (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48686", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + L-lysine => [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18917", "l": "5alpha-cholest-7-en-3beta-ol + H(+) + NADPH + O2 = cholesta-5,7-dien-3beta-ol + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983700", "l": "SYK binds the activated BCR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13004", "l": "1D-myo-inositol hexakisphosphate + H2O <=> 1L-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5631885", "l": "PRDX1 overoxidizes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210923", "l": "cya and lef bind to pagA(197-794):ANTXR1 oligomer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51042", "l": "chromopyrrolate + H(+) + NH4(+) => indole-3-pyruvate imine dimer"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27301", "l": "2-formylbenzoate + H2O + NAD(+) <=> 2 H(+) + NADH + phthalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11333", "l": "ATP + RNA(n) => diphosphate + RNA(n)-3'-adenine ribonucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47896", "l": "6-sulfo-D-quinovose + NAD(+) = 6-deoxy-6-sulfo-D-glucono-1,5-lactone + H(+) + NADH"}, {"i": "EC:1.1.1.390", "l": "\"Sulfoquinovose 1-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19903", "l": "alpha,beta-didehydrotryptophan + H2O2 => L-tryptophan + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76052", "l": "Binding of TFIIIA To type 1 Promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39483", "l": "3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938815", "l": "RNF152 polyubiquitinates RRAGA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22962", "l": "calycosin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => formononetin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60304", "l": "N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28636", "l": "(2E,6E)-farnesyl diphosphate => (+)-5-epi-aristolochene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26471", "l": "(E)-feruloyl-CoA + 16-hydroxyhexadecanoate => 16-feruloyloxyhexadecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52989", "l": "[deoxyhypusine synthase]-L-lysine + dehydrospermidine => [deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247841", "l": "PLCG1 binds to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43424", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112510", "l": "IL6ST is tyrosine phosphorylated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26219", "l": "abieta-7,13-dien-18-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => abieta-7,13-diene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050096", "l": "methylaspartate ammonia-lyase activity"}, {"i": "RHEA:12829", "l": "(2S,3S)-3-methyl-L-aspartate = mesaconate + NH4(+)"}, {"i": "EC:4.3.1.2", "l": "\"Methylaspartate ammonia-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678694", "l": "Heparanase 2 (HPSE2) cleaves heparan sulfate from its proteoglycan (plasma membrane) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38341", "l": "(20S)-ginsenoside Rd + D-glucose => (20S)-ginsenoside Rb1 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534359", "l": "CatSper Channel Mediated Calcium Transport (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38720", "l": "(R)-carnitine(out) + ATP + H2O => (R)-carnitine(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24896", "l": "isopimpinellin + S-adenosyl-L-homocysteine => 5-hydroxyxanthotoxin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035798", "l": "2-alkenal reductase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18727", "l": "acetyl-CoA + vanillin => 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27804", "l": "all-trans-decaprenyl diphosphate + 7 diphosphate => (2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25725", "l": "2 H(+) + H2O + N-hydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase] => L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21290", "l": "D-glucose 6-phosphate + glycerol => D-glucose + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44620", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphinganine = a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660663", "l": "Caspase-8 cleaves IL1B precursor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.9", "l": "\"Glucose-6-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625416", "l": "Anterograde IFT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396337", "l": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29318", "l": "alpha-D-galactose 1-phosphate + H2O <=> D-galactose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3296326", "l": "HCAR1 binds LACT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23246", "l": "H(+) + norspermidine + S-methyl-5'-thioadenosine => propane-1,3-diamine + S-adenosyl 3-(methylsulfanyl)propylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30196", "l": "15,9'-di-cis-phytofluene + plastoquinone-9 => 9,9',15-tri-cis-zeta-carotene + plastoquinol-9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102641", "l": "(R)-lactaldehyde dehydrogenase activity"}, {"i": "MetaCyc:RXN-15743"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46697", "l": "a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine => an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29376", "l": "AMP + H2O => adenosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56240", "l": "1,2-dioctanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = 2-octanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl octanoate + apo--[retinol-binding protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33547", "l": "H2O + lanosteryl hexadecanoate = H(+) + hexadecanoate + lanosterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65615", "l": "a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 21-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47008", "l": "[DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide = [DsrC protein]-dithiol + 2 AH2 + H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62992", "l": "H2O + tetradecamide = NH4(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.266", "l": "\"Glucosyl-3-phosphoglycerate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3095901", "l": "ABCC1 transports cytosolic Cbl to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088220", "l": "Endorepellin binds alpha2beta1 integrin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19752", "l": "[(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->3)-alpha-D-glucosyl](n+1) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396124", "l": "AGRN binds Laminins with gamma-1 subunit (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043273", "l": "CTPase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36172", "l": "a 1-acylglycerone 3-phosphate + a long chain fatty alcohol => 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51987", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983427", "l": "Expression of peptide bound class I MHC on cell surface (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13868", "l": "GDP-alpha-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol <=> beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65146", "l": "CO2 + H2O + preaustinoid A + succinate => 2-oxoglutarate + berkeleyone A + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38892", "l": "H2O + N-hexadecanoylsphing-4-enine => hexadecanoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36485", "l": "(7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15950", "l": "(R)-2-hydroxyoctadecanoate + NAD(+) => 2-oxodecanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51831", "l": "ATP(in) + CoA(in) + docosanoate(out) + H(+)(out) <=> AMP(in) + diphosphate(in) + docosanoyl-CoA(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43817", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18637", "l": "H2 + NADP(+) = H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37067", "l": "[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine"}, {"i": "EC:2.8.4.3", "l": "\"tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013157", "l": "CDC42 binds effectors at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28031", "l": "[thioredoxin]-disulfide + dGDP + H2O => [thioredoxin]-dithiol + GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2038946", "l": "Dimerization of FGFR4 mutants with enhanced kinase activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635854", "l": "GLI2,3 are degraded by the proteasome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19484", "l": "acetyl-CoA + succinyl-CoA <=> 3-oxoadipyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102121", "l": "ceramidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106078", "l": "histone succinyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20988", "l": "ATP + 2 H2O = AMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018747", "l": "RHOQ GEFs activate RHOQ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25887", "l": "carbamoyl phosphate + N(2)-succinyl-L-ornithine <=> H(+) + N(2)-succinyl-L-citrulline + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.47", "l": "\"Gingipain K\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61404", "l": "ATP + N-(D-ribulosyl)-cadaverine = ADP + H(+) + N-(3-O-phospho-D-ribulosyl)-cadaverine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36914", "l": "(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451033", "l": "(S)-Malate <=> Fumarate + H2O (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63755", "l": "kermesate + UDP-alpha-D-glucose <=> carminate + 2 H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31649", "l": "5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate => beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "65.423565948422279", "identifiers": [{"i": "GO:0043168", "l": "anion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-383190", "l": "HCO3- transport through ion channel (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58268", "l": "[protein]-C-terminal glycine + NAD(+) = [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614461", "l": "Tetramerization of procollagen VI (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55507", "l": "(5S,9S,10S)-drim-7-en-11-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> (5S,10S)-(9R)-7-drimene-11,12-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46763", "l": "2,4-dinitrotoluene + NADH + O2 <=> 4-methyl-5-nitrocatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49224", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + reduced [flavodoxin] = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H(+) + H2O + oxidized [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114684", "l": "Phosphorylation of Syntaxin-4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.53"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785898", "l": "IL4R binds JAK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211948", "l": "CYP3A4 can N-demethylate loperamide (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391939", "l": "TP receptor can bind thromboxane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3262512", "l": "G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202947", "l": "Caspase mediated cleavage of APC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33099", "l": "acetyl-CoA + spermine = CoA + H(+) + N(1)-acetylspermine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56782", "l": "(+)-sesamin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (+)-piperitol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33047", "l": "(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] = (+)-6-endo-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]"}, {"i": "EC:1.14.15.10", "l": "\"(+)-camphor 6-endo-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65527", "l": "9-cis-retinal + O2 + reduced [NADPH--hemoprotein reductase] <=> 9-cis-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34206", "l": "2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 <=> aureusidin 6-O-beta-glucoside + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39893", "l": "dTDP + H(+) + vancomycin => devancoaminyl-vancomycin + dTDP-beta-L-vancosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44554", "l": "H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine => 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706328", "l": "Active FLT3 binds to SOCS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "66.037418768212447", "identifiers": [{"i": "GO:0005342", "l": "organic acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690152", "l": "USP5 cleaves polyubiquitin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618582", "l": "CEBPA binds MYC gene:E2F1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39310", "l": "(2E,11Z,14Z)-eicosatrienoyl-CoA + H(+) + NADPH <=> (11Z,14Z)-eicosadienoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982645", "l": "GRKs bind ADRB2:Catecholamine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49304", "l": "a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23905", "l": "an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] => 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24996", "l": "N-hydroxy-L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956659", "l": "ABL1 phosphorylates YAP1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044022", "l": "histone kinase activity (H3-S28 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66353", "l": "(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + NAD(+) => (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36678", "l": "octacosanoyl-CoA + sphinganine <=> CoA + H(+) + N-(octacosanoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38071", "l": "2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786190", "l": "CMBL hydrolyses OM to OLMS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16294", "l": "2-isopropylmaleate + H2O => (2S)-2-isopropylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014456", "l": "GDIs block activation of RHOG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50828", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 = (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E)-docosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28708", "l": "Cd(2+)(in) => Cd(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21780", "l": "A + cyclohexanone = AH2 + cyclohex-2-enone"}, {"i": "EC:1.3.99.14", "l": "\"Cyclohexanone dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56482", "l": "(3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621615", "l": "CD209 binds ICAM3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141341", "l": "SMOX-3 oxidises SPN to SPM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73757", "l": "Binding of RRN3 to RNA Polymerase I (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47689", "l": "cis-4-hydroxy-L-proline + NADP(+) => Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.386", "l": "\"Ipsdienol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31536", "l": "2-oxoglutarate + L-arginine + O2 => (S)-1-pyrroline-5-carboxylate + CO2 + guanidine + H(+) + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0016662", "l": "oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor"}, {"i": "EC:1.7.2.-", "l": "\"With a cytochrome as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-901047", "l": "Binding of ERp57 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24099", "l": "isoorientin + S-adenosyl-L-methionine <=> H(+) + isoscoparin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61259", "l": "H2O + L-cysteine + O2 <=> 2-oxo-3-sulfanylpropanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450063", "l": "Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696997", "l": "USP24 deubiquitinates DDB2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6795460", "l": "SGK1 phosphorylates MDM2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23996", "l": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873794", "l": "PCTP binds PC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691154", "l": "HFE binds TFRC dimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001093", "l": "TFIIB-class transcription factor binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051381", "l": "histamine binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050395", "l": "vitexin beta-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62087", "l": "ADP + D-glucosamine <=> AMP + D-glucosamine 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16735", "l": "CO2 + orcinol => H(+) + orsellinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.13", "l": "\"RNA helicase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13256", "l": "1D-myo-inositol 1,3,4-trisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617452", "l": "Retinoic acid activates HOXB1 chromatin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113449", "l": "RNA Polymerase III Transcriptional Pause at Terminator Sequence (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33021", "l": "(3S)-6-acetamido-3-aminohexanoate + CoA + H(+) => (3S)-3,6-diaminohexanoate + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13296", "l": "3 H(+) + malonyl-CoA + 2 NADPH + octadecanoyl-CoA <=> CO2 + CoA + eicosanoyl-CoA + H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64608", "l": "L-threonyl-[protein] + UTP = diphosphate + uridylyl-L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55272", "l": "11-cis-retinol + tetradecanoyl-CoA = 11-cis-retinyl tetradecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35413", "l": "an anthocyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D--glucoside] + CoA + H(+) => (E)-4-coumaroyl-CoA + an anthocyanidin 3-O-beta-D-glucoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18540", "l": "H2O + NAD(+) + salicylaldehyde <=> 2 H(+) + NADH + salicylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.57"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693609", "l": "ATM phosphorylates TP53 at S15 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193650", "l": "p75NTR binds to NADE (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63835", "l": "(6E)-8-methylnon-6-enoyl-CoA + vanillylamine <=> capsaicin + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010291", "l": "carotene beta-ring hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23818", "l": "4-aminobutanal + L-glutamate => 2-oxoglutarate + putrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35936", "l": "2 ATP + L-proline + L-tryptophan => 2 AMP + brevianamide F + 2 diphosphate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21118", "l": "beta-D-glucose 1-phosphate + D-glucose => D-maltose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844618", "l": "dsDNA:AIM2:ASC cluster binds procaspase-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12286", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + succinate => 3-hydroxy-3-methylglutarate + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1461982", "l": "Alpha-defensin dimers multimerize to form a pore complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9696275", "l": "RND2 binds GTP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23838", "l": "4-methylsulfanyl-2-oxobutanoate + L-alanine => D-methionine + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63547", "l": "H2O + kinetensin <=> kinetensin-(1-8) + L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42493", "l": "3'-N-debenzoyl-2'-deoxytaxol + AH2 + O2 => 3'-N-debenzoyltaxol + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47208", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54555", "l": "1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70479", "l": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39146", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + NAD(+) <=> 3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683888", "l": "LMCD1 binds GATA6, sequestering it (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189062", "l": "lactose + H2O => D-glucose + D-galactose (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000120", "l": "CBLIF binds Cbl (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730835", "l": "Autophosphorylation of PKC-theta (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63393", "l": "A + Fe(II)-heme o + H2O => AH2 + Fe(II)-heme i"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.46", "l": "\"Memapsin 2\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34929", "l": "glutathione + glutathioselenol + NADP(+) => H(+) + NADPH + selenodiglutathione"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062065", "l": "box H/ACA snoRNP complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420243", "l": "GHRH receptor binds GHRH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42330", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173642", "l": "Disintegration of matrix layer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex. (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451377", "l": "Interaction of IQGAP1 with nephrin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372697", "l": "Crk binding to p130cas (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981353", "l": "RASA1 stimulates RAS GTPase activity (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39843", "l": "1,3-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1370500", "l": "PRLR binds SCF beta-TrCP complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43853", "l": "H(+) + malonyl-CoA + triacontanoyl-CoA => 3-oxo-dotriacontanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14353", "l": "3-dehydro-L-gulonate 6-phosphate + H(+) = CO2 + L-xylulose 5-phosphate"}, {"i": "EC:4.1.1.85", "l": "\"3-dehydro-L-gulonate-6-phosphate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48740", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + O-phospho-L-serine = [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + phosphate"}, {"i": "EC:2.5.1.113", "l": "\"[CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77068", "l": "Activation of GT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110311", "l": "POLZ extends translesion synthesis (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60118", "l": "CO2 + hydroxymethylphosphonate + succinate => 2-oxoglutarate + methylphosphonate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938913", "l": "RUNX1 binds ELF1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32429", "l": "(S)-carvone + AH2 => (1R,4S)-isodihydrocarvone + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416320", "l": "Trafficking of GluR1-containing  AMPA receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905059", "l": "P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8856157", "l": "LAG3 (CD233) binds MHC II (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052856", "l": "NADHX epimerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165179", "l": "Formation of TSC1:TSC2 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24151", "l": "D-glyceraldehyde 3-phosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (2R)-3-phosphoglycerate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32834", "l": "cob(III)alamin(in) <=> cob(III)alamin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45460", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a fatty acid + H(+) + N,1-diacyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193068", "l": "CYP17A1 17-hydroxylates PREG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15936", "l": "(S)-propane-1,2-diol + NAD(+) <=> (S)-lactaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2980720", "l": "NEK9 binds NEK6/NEK7 in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57678", "l": "4-epi-eremophilene-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4-epi-eremophilene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47832", "l": "ganglioside GD1a + H2O = ganglioside GM1 + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54963", "l": "ATP + CoA + dinor-OPDA <=> AMP + dinor-OPDA-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57647", "l": "(3-{(1R,2S,6S,8R)-2,8-dimethyl-3-[(E)-prop-1-enyl]-4,5-didehydrodecalin-2-yl}-3-oxopropanoyl)-[equisetin nonaketide synthase] + L-serine <=> H(+) + H2O + holo-[equisetin nonaketide synthase] + trichosetin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17406", "l": "N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine => H(+) + N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635854", "l": "GLI2,3 are degraded by the proteasome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18000", "l": "Co-precorrin-2 + S-adenosyl-L-methionine <=> Co-precorrin-3 + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11086", "l": "CO2 + L-xylulose => 3-dehydro-L-gulonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12960", "l": "an acetyl ester + H2O <=> acetate + an aliphatic alcohol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30816", "l": "beta-nicotinamide D-ribonucleotide + H2O => beta-nicotinamide D-riboside + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20332", "l": "ATP + L-seryl-[low-density-lipoprotein receptor] <=> ADP + H(+) + O-phospho-L-seryl-[low-density-lipoprotein receptor]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5336443", "l": "LIN7, CASK and APBA1 bind (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31421", "l": "(-)-beta-curcumene + diphosphate => (2Z,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626356", "l": "Defective SLC24A5 does not exchange cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008877", "l": "glucose-1-phosphatase activity"}, {"i": "RHEA:19933", "l": "alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate"}, {"i": "EC:3.1.3.10", "l": "\"Glucose-1-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48013", "l": "4-methyl-5-nitrocatechol + NADPH + O2 => 2-hydroxy-5-methylquinone + H(+) + H2O + NADP(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49250", "l": "galactitol 1-phosphate(in) + L-histidyl-[protein] => galactitol(out) + N(pros)-phospho-L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62414", "l": "acetyl-CoA + vanillin => (E)-feruloyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392513", "l": "Rap1 signal termination by Rap1GAPs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56766", "l": "12-epi-fischerindole G + CO2 + H2O + succinate => 12-epi-fischerindole U + 2-oxoglutarate + chloride + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35906", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29070", "l": "formate + H(+) + menaquinone-8 <=> CO2 + menaquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40632", "l": "H2O + trioctadecanoylglycerol => 2,3-dioctadecanoyl-sn-glycerol + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19101", "l": "2-butyne-1,4-diol + NAD(+) = 4-hydroxy-2-butynal + H(+) + NADH"}, {"i": "EC:1.1.1.165", "l": "\"2-alkyn-1-ol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174203", "l": "SCF-mediated degradation of Emi1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047929", "l": "gluconate dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23706", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 2 H(+) => GTP + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805022", "l": "USP2 binds the heterodimer of MDM2 and MDM4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31246", "l": "H2O + L-4-hydroxyglutamate semialdehyde + NAD(+) <=> (4S)-4-hydroxy-L-glutamate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009485", "l": "IL34:CSF1 binds CSF1R (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55288", "l": "tetradecan-1-ol + tetradecanoyl-CoA = CoA + tetradecanyl tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20292", "l": "acetyl-CoA + H2O <=> acetate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878702", "l": "p-BMAL1:p-CLOCK,NPAS2 binds KLF15 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72180", "l": "Cleavage of mRNA at the 3'-end (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15475", "l": "flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] + H(+) + UDP => flavanone 7-O-beta-D-glucoside + UDP-beta-L-rhamnose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24699", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A => 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + a 1,2-diacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004636", "l": "phosphoribosyl-ATP diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24577", "l": "diphosphate + H2O => H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806974", "l": "MET dimers autophosphorylate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52768", "l": "2-(glutathion-S-yl)-2-(1H-indol-3-yl)acetonitrile + H2O = 2-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10883", "l": "7-methylxanthosine + H2O <=> 7-methylxanthine + D-ribose + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018517", "l": "phthalate 4,5-cis-dihydrodiol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202437", "l": "Phosphorylation of CARMA1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59764", "l": "L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + octadecanoyl-CoA = CoA + H(+) + N(6)-octadecanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43268", "l": "ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GM2 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10178", "l": "(R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH => (2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64763", "l": "H2O + S-ethyl-L-cysteine <=> ethanethiol + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433451", "l": "JAK2 binds to p-KIT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52033", "l": "H2O + L-isoleucine-(+)-7-isojasmonate => (+)-7-isojasmonate + L-isoleucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879562", "l": "SLCO2B1 has a narrow substrate specificity (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31717", "l": "11alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070579", "l": "methylcytosine dioxygenase activity"}, {"i": "REACT:R-HSA-5220990", "l": "TET1,2,3 oxidizes 5-hydroxymethylcytosine to 5-formylcytosine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31746", "l": "a 4'-hydroxyflavanone + S-adenosyl-L-methionine <=> a 4'-methoxyflavanone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66045", "l": "2-oxobutanoate + L-kynurenine => (2S)-2-aminobutanoate + H2O + kynurenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029555", "l": "NR1H2,3 binds the ABCG8 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30842", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-talose <=> UDP-N-acetyl-beta-L-fucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.n2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709098", "l": "DHFR dimer reduces FOLA to DHF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306876", "l": "NLRP3 activation by small molecules (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19261", "l": "ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate"}, {"i": "EC:7.6.2.5", "l": "\"ABC-type heme transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418858", "l": "RhoGTPase GEF's recruited to DCC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429860", "l": "DCP1-DCP2 complex decaps mRNA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29753", "l": "acetoacetate(out) => acetoacetate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38923", "l": "a ubiquinone + H(+) + Na(+)(in) + NADH = a ubiquinol + Na(+)(out) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351208", "l": "Spermidine  => N-acetylated spermidine (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37484", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-dodecanoyl-sn-glycero-3-phosphocholine => 1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0008800", "l": "beta-lactamase activity"}, {"i": "RHEA:20401", "l": "a beta-lactam + H2O = a substituted beta-amino acid"}, {"i": "EC:3.5.2.6", "l": "\"Beta-lactamase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55082", "l": "ADP + H(+) + sucrose => ADP-alpha-D-glucose + D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55088", "l": "24-methylene-24-dihydrolanosterol + S-adenosyl-L-methionine = (24Z)-ethylidenelanosterol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19396", "l": "L-lysine + pyruvate <=> (S)-2-amino-6-oxohexanoate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34422", "l": "(+)-lariciresinol + NADP(+) <=> (+)-pinoresinol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43506", "l": "2,5-diformylfuran + H2O2 => 5-hydroxymethylfurfural + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395517", "l": "NADPH transfers electrons to FDXR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9677585", "l": "CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865774", "l": "TTLLs polyglutamylate tubulin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63952", "l": "a sphingoid 1-phosphate + H2O = a sphingoid base + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392870", "l": "Gs activation by prostacyclin receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39250", "l": "(3R)-hydroxy-(11Z)-eicosenoyl-CoA <=> (2E,11Z)-eicosadienoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023351", "l": "DLL1 gene expression is inhibited by MECP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29576", "l": "L-serine(in) + Na(+)(in) => L-serine(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29772", "l": "arsenate(in) + ATP + H2O => ADP + arsenate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625378", "l": "STK11 gene transcription is stimulated by FOXO3,FOXO4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090710", "l": "phosphomevalonate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8862280", "l": "FCHo proteins bind nascent clathrin-coated pit (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354087", "l": "Recruitment of GRB2 to p-PTK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28456", "l": "N(6)-(D-fructosyl)-L-lysine(out) => N(6)-(D-fructosyl)-L-lysine(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0050734", "l": "hydroxycinnamoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37097", "l": "3-oxo-(12Z,15Z,18Z,21Z)-tetracosatetraenoyl-CoA + CO2 + CoA => (10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047466", "l": "2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051035", "l": "DNA transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668417", "l": "cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709918", "l": "PTK6 phosphorylates STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-984671", "l": "Chromokinesins form dimers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44254", "l": "1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65862", "l": "17beta-hydroxyandrostan-1,3-dione + AH2 => A + Delta(1)-dihydrotestosterone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71825", "l": "G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904768", "l": "all-trans-retinol binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45577", "l": "(2R)-ethylmalonyl-CoA => (2S)-methylsuccinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112385", "l": "Addition of nucleotides leads to transcript elongation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41926", "l": "(2E)-octadecenoyl-[ACP] + H2O => (3R)-hydroxyoctadecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168849", "l": "tBID binds to inactive BAX protein (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20303", "l": "AMP + diphosphate + L-arginyl-tRNA(Arg) => ATP + L-arginine + tRNA(Arg)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018814", "l": "RHOT1 hydrolyzes GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015217", "l": "ADP transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034563", "l": "2,3-bis(4-hydroxyphenyl)-1,2-propanediol dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168299", "l": "Ribonucleoprotein release from M1 proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062131", "l": "3-butenylglucosinolate 2-hydroxylase activity"}, {"i": "RHEA:60628", "l": "AH2 + gluconapin + O2 = A + H2O + xi-progoitrin"}, {"i": "MetaCyc:RXNQT-4343"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48399", "l": "(3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine <=> 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62499", "l": "ATP + H(+) + L-arginine <=> diphosphate + L-arginyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43356", "l": "cholesteryl (9Z,12Z)-octadecadienoate(in) = cholesteryl (9Z,12Z)-octadecadienoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68610", "l": "Formation of ORC(2-5) complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0039630", "l": "RNA translocase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51560", "l": "(S)-bulbocapnine + S-adenosyl-L-methionine = (S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62719", "l": "stemphyloxin I <=> stemphyloxin II"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11285", "l": "hydroxymalonate + NAD(+) => H(+) + NADH + oxomalonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229343", "l": "AXIN is phosphorylated in the destruction complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16421", "l": "an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.2.7.5", "l": "\"Aldehyde ferredoxin oxidoreductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24692", "l": "(E)-coniferyl acetate + NADPH => acetate + eugenol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903879", "l": "11beta-hydroxyprogesterone binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38073", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112514", "l": "JAK activation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018561", "l": "2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23428", "l": "3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050093", "l": "methanol dehydrogenase activity"}, {"i": "KEGG.REACTION:R00605"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39199", "l": "(3R)-hydroxytetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23243", "l": "5-formyltetrahydrofolate + L-glutamate <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51819", "l": "ATP(in) + CoA(in) + dodecanoate(out) + H(+)(out) <=> AMP(in) + diphosphate(in) + dodecanoyl-CoA(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30428", "l": "(2E,6E)-farnesyl diphosphate => (+)-germacrene D + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001876", "l": "lipoarabinomannan binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "78.047734625335977", "identifiers": [{"i": "GO:0016841", "l": "ammonia-lyase activity"}, {"i": "EC:4.3.1.-", "l": "\"Ammonia-lyases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27867", "l": "(2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate + H2O => (R)-glycerate + alpha-D-mannose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55766", "l": "2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol => 1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182594", "l": "Association of INK4 family proteins with CDK4/6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39228", "l": "(2E)-octacosenoyl-CoA + H(+) + NADPH => NADP(+) + octacosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63708", "l": "2 [Fe(II)-cytochrome b5] + a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl derivative + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl derivative + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39800", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+) => 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000252", "l": "C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632039", "l": "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169402", "l": "ISGylation of E2 conjugating enzymes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57345", "l": "3-hydroxy-D-kynurenine + S-adenosyl-L-methionine => 3-hydroxy-4-methyl-D-kynurenine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191830", "l": "snRNP nuclear import and release (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609899", "l": "Tail-anchored protein:ASNA1:ADP binds WRB:CAMLG at the endoplasmic reticulum membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080116", "l": "glucuronoxylan glucuronosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11185", "l": "3-(carbamoylamino)propanoate + 2 H(+) + H2O => beta-alanine + CO2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45328", "l": "7,8-dihydroneopterin = 7,8-dihydromonapterin"}, {"i": "EC:5.1.99.8", "l": "\"7,8-dihydroneopterin epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43881", "l": "3beta-hydroxy-5-cholestenoate + ATP + CoA => 3beta-hydroxy-5-cholestenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10491", "l": "5-formyltetrahydrofolate + ATP <=> 5,10-methenyltetrahydrofolate + ADP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.3", "l": "\"Lysine carboxypeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.55"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098872", "l": "G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070326", "l": "very-low-density lipoprotein particle receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668605", "l": "RAC2:GTP binds NOX2 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814555", "l": "Integrator complex processes the 3' end of snRNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0017169", "l": "CDP-alcohol phosphatidyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14763", "l": "3-oxosphinganine + CO2 + CoA => H(+) + hexadecanoyl-CoA + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19934", "l": "alpha-D-glucose 1-phosphate + H2O => D-glucose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937807", "l": "SRC phosphorylates RUNX3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0019770", "l": "IgG receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44591", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-1D-myo-inositol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18394", "l": "(R)-3-amino-2-methylpropanoate + pyruvate => 2-methyl-3-oxopropanoate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27868", "l": "(R)-glycerate + alpha-D-mannose 6-phosphate => (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38753", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2468040", "l": "Cohesin binds PDS5 and WAPAL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60427", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + valerianol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2997706", "l": "MDM2 SUMOylates TP53 with SUMO2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29220", "l": "a menaquinone + sn-glycerol 3-phosphate => a menaquinol + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102499", "l": "SHG alpha-glucan phosphorylase activity"}, {"i": "MetaCyc:RXN-14353"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53951", "l": "ATP + holo-[BtrI ACP] + L-glutamate <=> ADP + gamma-L-glutamyl-[BtrI ACP] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018507", "l": "cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3244643", "l": "STING binds cyclic GMP-AMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64891", "l": "ATP + holo-[ACP] + tetradecanoate <=> AMP + diphosphate + tetradecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388830", "l": "PI3K binds ICOS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5688797", "l": "ATXN3 family cleave Ub chains (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62317", "l": "salicylate + UDP-alpha-D-glucose => 1-O-salicyl-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48418", "l": "CMP + ganglioside GM2 (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E))"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706364", "l": "Internalization of ubiquitinated FLT3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56954", "l": "CDP + H(+) + phosphoenolpyruvate => CTP + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391941", "l": "BLT receptors can bind LTB4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9737111", "l": "Protonated weak acid translocates across the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684140", "l": "ATM phosphorylates RBBP8 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66905", "l": "A + cannabinerolate => AH2 + cannabichromenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62045", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphoglycerol + H2O => (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphoglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49103", "l": "H2O + Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63736", "l": "2-phenylacetaldehyde + H(+) + NADPH = 2-phenylethanol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0032296", "l": "double-stranded RNA-specific ribonuclease activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902301", "l": "galactarate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29088", "l": "(S)-malate + menaquinone-8 => menaquinol-8 + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34026", "l": "3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(+) <=> (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13103", "l": "H2O + trans-urocanate => 4-imidazolone-5-propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8953111", "l": "E2F6 binds TFDP1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29315", "l": "alpha-D-galactose 1-phosphate + H2O = D-galactose + phosphate"}, {"i": "EC:3.1.3.94", "l": "\"D-galactose 1-phosphate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017056", "l": "structural constituent of nuclear pore"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33068", "l": "(4R)-hydroxysphinganine 1-phosphate + H2O => (4R)-hydroxysphinganine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5688294", "l": "SIRT5 deacetylates Cytochrome C (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12378", "l": "ADP + H(+) + L-fuculose 1-phosphate => ATP + L-fuculose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30531", "l": "biotinate sulfoxide + H(+) + NADH = biotin + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58416", "l": "(E)-4-hydroxynon-2-en-1-ol + NADP(+) = (E)-4-hydroxynon-2-enal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193700", "l": "p75NTR ICD signals to NF-kB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9634834", "l": "ACHEIs bind ACHE (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5432849", "l": "S100A8:S100A9 binds TLR4:LY96 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46092", "l": "(25R)-cholest-5-ene-3beta,26-diol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxy-5-cholesten-26-al + 2 H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36665", "l": "(2S,5S)-5-carboxymethylproline + CO2 + CoA => (S)-1-pyrroline-5-carboxylate + H(+) + H2O + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-166220", "l": "FA anion diffuses laterally to UCP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10492", "l": "H2O + phosphocholine = choline + phosphate"}, {"i": "RHEA:16089", "l": "H2O + phosphoethanolamine = ethanolamine + phosphate"}, {"i": "EC:3.1.3.75", "l": "\"Phosphoethanolamine/phosphocholine phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.41", "l": "\"Xylogalacturonan beta-1,3-xylosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41712", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51051", "l": "5alpha-androstan-3,17-dione + A <=> AH2 + androst-4-ene-3,17-dione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2995334", "l": "COX15 transforms heme O to heme A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50131", "l": "NAD(+) + resolvin D1 <=> 17-oxoresolvin D1 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46327", "l": "3-oxochol-4-en-22-oyl-CoA + A <=> 3-oxochola-4,17-dien-22-oyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43312", "l": "ATP + N-(hexanoyl)sphing-4-enine = ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9663511", "l": "BIL binds GSTA1, FABP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112604", "l": "Phosphorylated STATs are released (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30499", "l": "H(+) + N,N-dihydroxy-L-valine = (E)-2-methylpropanal oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8934742", "l": "RUNX1 binds PRMT1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373732", "l": "Nephrin trans-homophilic interaction (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66033", "l": "alpha-D-mannose 1-phosphate + GDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19088", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-glucose <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38416", "l": "1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O => (9Z,12Z,15Z)-octadecatrienoate + 2,3-di-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032442", "l": "phenylcoumaran benzylic ether reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863494", "l": "ASICs bind STOML3, (STOM) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27349", "l": "arsenate + mycothiol = arseno-mycothiol + H2O"}, {"i": "EC:2.8.4.2", "l": "\"Arsenate-mycothiol transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23661", "l": "4-imidazolone-5-propanoate + H2O => N-formimidoyl-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48481", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + UDP-alpha-D-galactose => 1,2-di-(9Z-octadecenoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17312", "l": "a phenyl acetate + H2O <=> a phenol + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201634", "l": "Caspase-mediated cleavage of FADK 1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9674093", "l": "PDGFRs bind type I TKI (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47080", "l": "17beta-hydroxyestr-4-en-3-one + H(+) + NADPH = 17beta-hydroxy-5beta-estran-3-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690152", "l": "USP5 cleaves polyubiquitin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693598", "l": "ATM phosphorylates NBN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25272", "l": "(R)-noradrenaline + S-adenosyl-L-methionine <=> (R)-adrenaline + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16762", "l": "chlorohydroquinone + O2 => 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2029473", "l": "Branching and elongation of mother and daughter filaments (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-870538", "l": "TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.27"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214847", "l": "Phosphorylated CACT and DL dimer dissociate from the TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41750", "l": "1,2-diacyl-3-(3-O-sulfo-beta-D-galactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16583", "l": "2 [Fe(III)cytochrome c] + 2 H2O => 2 [Fe(II)cytochrome c] + 2 H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15556", "l": "1D-myo-inositol 1,4-bisphosphate + H2O <=> 1D-myo-inositol 4-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032323", "l": "oxo-DPAn-3s translocate from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034943", "l": "trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48109", "l": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine => 2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031781", "l": "type 3 melanocortin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14288", "l": "sn-glycerol 3-phosphate + UDP-alpha-D-galactose <=> 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850831", "l": "KLK5 cleaves and activates KLK8 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.251", "l": "\"Lipid IV(A) palmitoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0010436", "l": "carotenoid dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800380", "l": "PTPRD binds IL1RAP-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32600", "l": "7-hydroxy-4-isopropenyl-7-methyloxepan-2-one => 3-isopropenyl-6-oxoheptanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47763", "l": "a uridine in 21S rRNA + S-adenosyl-L-methionine <=> a 2'-O-methyluridine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11289", "l": "dihydromacarpine + H(+) + O2 => H2O2 + macarpine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47198", "l": "a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034948", "l": "2,6-dihydroxypseudooxynicotine hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50357", "l": "4-hydroxy-6-methylpretetramide + NADPH + O2 => 4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49100", "l": "H2O + Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine = 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433592", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851866", "l": "MET binds RANBP10 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34765", "l": "(S,S)-tartrate(in) + succinate(out) => (S,S)-tartrate(out) + succinate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12627", "l": "D-glucose + sinapoyl (S)-malate => (S)-malate + 1-O-(trans-sinapoyl)-beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18974", "l": "2-oxoglutarate + deacetoxyvindoline + O2 => 4-O-deacetylvindoline + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42482", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + catechol + H(+) => 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49268", "l": "25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 23S,25-dihydroxy-24-oxocholecalciferol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3636919", "l": "Defective CHST14 does not transfer SO4(2-) to GalNAc in dermatan or DS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199203", "l": "PANK1/3/4 phosphorylate PanK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604752", "l": "Initial activation of proMMP13 by MMP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25909", "l": "an alditol + O2 => an aldose + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109858", "l": "MAP2K2 binds MAPK1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40367", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP = 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63306", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209057", "l": "Activated PLL kinase is autophosphorylated in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395784", "l": "Nascent CMs transform into mature CMs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730904", "l": "Auto-ubiquitination of TRAF6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30979", "l": "A + all-trans-lycopene = AH2 + all-trans-3,4-didehydrolycopene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29034", "l": "L-glutamate(in) + Na(+)(in) <=> L-glutamate(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014467", "l": "RHOG binds effectors at the ER membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390059", "l": "HPO dimer binds to RASSF (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59584", "l": "ATP + beta-alanine + L-lysine = ADP + beta-alanyl-L-lysine + H(+) + phosphate"}, {"i": "EC:6.3.2.11", "l": "\"Carnosine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54367", "l": "2 acetaldehyde <=> acetoin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696605", "l": "USP12, USP26 deubiquitinate AR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050385", "l": "ureidoglycolate lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58066", "l": "5-hydroxyxanthotoxin + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + xanthotoxin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13051", "l": "D-fructuronate => D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11282", "l": "(6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dCMP => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.151", "l": "\"Alkylcobalamin dealkylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950389", "l": "Expression of Stress-70 protein, mitochondrial (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5618328", "l": "ATAT acetylates microtubules (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982709", "l": "G-alpha(z):PKC dissociates to give phosphorylated G alpha (z) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047410", "l": "N-formylmethionylaminoacyl-tRNA deformylase activity"}, {"i": "MetaCyc:3.5.1.27-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "79.238648346243679", "identifiers": [{"i": "GO:0008169", "l": "C-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51805", "l": "deoxyhumulone + dimethylallyl diphosphate => diphosphate + H(+) + lupulone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23716", "l": "(3Z)-dodecenoyl-CoA = (2E)-dodecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56158", "l": "(12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864936", "l": "VEGFA gene expression is inhibited by the TFAP2A homodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678843", "l": "ISGylation of protein translation regulator 4EHP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60360", "l": "FMN + H(+) + oxidized coenzyme F420-0 = dehydro coenzyme F420-0 + FMNH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64798", "l": "(S)-2-amino-6-oxohexanoate + H(+) + NADPH + NH4(+) => H2O + L-lysine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25228", "l": "L-arabinitol + NAD(+) <=> H(+) + L-arabinose + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168400", "l": "iE-DAP elicits a NOD1 response (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19424", "l": "(R)-2-hydroxypropyl-coenzyme M <=> (R)-1,2-epoxypropane + coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62478", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+) => 3,4-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3134962", "l": "DHX36 binds DNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40928", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O => (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63841", "l": "[thioredoxin]-dithiol + tert-butyl hydroperoxide => [thioredoxin]-disulfide + H2O + tert-butanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692764", "l": "MAPK6 binds CCND3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30358", "l": "a quinol + methane + O2 <=> a quinone + H2O + methanol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033404", "l": "UUG codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391871", "l": "Autophosphorylation of NCAM1 bound Fyn (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192925", "l": "Export of Spliced Viral mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50171", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 <=> N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51068", "l": "(2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + pyruvate = (3S,5R,10R,12S,14S,15R,16R)-3,5,10,14,15-pentahydroxy-12,16-dimethylicosan-2-one + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21069", "l": "A + H2O + nitrite => AH2 + nitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62546", "l": "2 [Fe(III)cytochrome c] + dihydroouabagenin => 2 [Fe(II)cytochrome c] + 3 H(+) + ouabagenin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730835", "l": "Autophosphorylation of PKC-theta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015153", "l": "rhamnose transmembrane transporter activity"}, {"i": "RHEA:34995", "l": "L-rhamnose(in) = L-rhamnose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47191", "l": "[Co(I) methylated-thiol-specific corrinoid protein] + methanethiol <=> [methyl-Co(III) methylated-thiol-specific corrinoid protein] + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22031", "l": "acetyl-CoA + taxa-4(20),11-dien-5alpha-ol <=> CoA + taxa-4(20),11-dien-5alpha-yl acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31262", "l": "but-3-ynal + H2O + NAD(+) <=> 3-butynoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36174", "l": "a 1-acylglycerone 3-phosphate + a long chain fatty alcohol <=> 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32641", "l": "(6E)-8-oxolinalool + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6E)-8-hydroxylinalool + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50621", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose => alpha-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24737", "l": "2-oxoglutarate + 4-hydroxybutanoate <=> (R)-2-hydroxyglutarate + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389026", "l": "Galanin receptors can bind galanin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351913", "l": "Caspase-mediated cleavage of TJP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849797", "l": "Membrane proteases cleave Profilaggrin producing Filaggrin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38821", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52039", "l": "H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate <=> L-isoleucine + tuberonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20368", "l": "phosphoethanolamine + S-adenosyl-L-methionine <=> H(+) + N-methylethanolamine phosphate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5679205", "l": "ULK1 phosphorylates Beclin-1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33805", "l": "2 H(+) + L-histidine + NADH => H2O + L-histidinal + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070089", "l": "chloride-activated potassium channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25466", "l": "diphosphate + longifolene => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49903", "l": "5,10-dihydrophenazine-1,6-dicarboxylate + O2 <=> H2O2 + phenazine-1,6-dicarboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40158", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036433", "l": "di-trans, poly-cis-undecaprenol kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24761", "l": "H(+) + L-dopa + NADH => 3-(3,4-dihydroxyphenyl)propanoate + NAD(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37300", "l": "H2O + L-alanyl-L-threonine => L-alanine + L-threonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31063", "l": "3-methylbutanoyl-CoA + FAD + H(+) = 3-methyl-(2E)-butenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858270", "l": "HILPDA binds lipid droplets (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44388", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-heptadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29938", "l": "cytosine(in) + H(+)(in) <=> cytosine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2245218", "l": "CDK1 phosphorylates PHF8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638845", "l": "CERK phosphorylates CERA to form C1P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809663", "l": "Formation of hair keratin fibres (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051087", "l": "chaperone binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047672", "l": "anthranilate N-benzoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195304", "l": "Association of beta-catenin with the destruction complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44042", "l": "14,15-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13027", "l": "N(6)-biotinyl-L-lysyl-[protein] + trans-3-methylglutaconyl-CoA => 3-methyl-(2E)-butenoyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61956", "l": "1-O-octadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22798", "l": "ADP + D-hamamelose 2'-phosphate + H(+) => ATP + D-hamamelose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37129", "l": "CO2 + H(+) + phosphonate + succinate => 2-oxoglutarate + dioxidophosphate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51440", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (11S)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617829", "l": "Assembly of IFT A complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47629", "l": "glyoxylate + H2O + propanoyl-CoA => 3-methylmalate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9710263", "l": "GZMB cleaves GSDME (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13810", "l": "aspulvinone E + 2 dimethylallyl diphosphate => aspulvinone H + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31691", "l": "(9Z,12Z)-octadecadienoate + O2 = (9R)-hydroperoxy-(10E,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17484", "l": "2 cob(I)alamin + H(+) + NAD(+) <=> 2 cob(II)alamin + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627350", "l": "SMAC (DIABLO) binds XIAP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51959", "l": "(E)-2-methylpropanal oxime <=> (Z)-2-methylpropanal oxime"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8949580", "l": "F1Fo ATP synthase dimerizes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20210", "l": "ATP + xylitol => ADP + H(+) + xylitol 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13439", "l": "1-O-(trans-cinnamoyl)-beta-D-glucose + UDP => (E)-cinnamate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45649", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45278", "l": "12-hydroxy-(9E)-octadecenoate + phosphate => 12-phosphooxy-(9E)-octadecenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56162", "l": "an archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate + H(+) + UDP => an archaeal dolichyl alpha-D-glucosyl phosphate + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0072586", "l": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693198", "l": "RHOD binds effectors at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980065", "l": "NOTCH1 stimulates HEY transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102592", "l": "delphinidin 7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) acyltransferase (acyl-glucose dependent activity"}, {"i": "MetaCyc:RXN-15354"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015473", "l": "fimbrial usher porin activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55890", "l": "[excited state blue fluorescent protein] + CO2 => [aequorin]--dioxetanone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6795667", "l": "MDM2 translocates to the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604763", "l": "Autocatalytic activation of MMP7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156923", "l": "Hydrolysis of eEF1A:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52896", "l": "2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin = 2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate"}, {"i": "EC:6.3.5.12", "l": "\"Ni-sirohydrochlorin a,c-diamide synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0031711", "l": "bradykinin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59543", "l": "(2R)-ethylmalonyl-CoA + H(+) <=> butanoyl-CoA + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29551", "l": "H2O + UDP-alpha-D-glucose = alpha-D-galactose 1-phosphate + 2 H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0003857", "l": "3-hydroxyacyl-CoA dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45093", "l": "H2O + N-octanoylsphing-4-enine => octanoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25341", "l": "H(+) + urea <=> isocyanate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64629", "l": "acetyl-CoA + octan-1-ol => CoA + octyl acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810234", "l": "General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59417", "l": "H2O + O2 + tryptamine => H2O2 + indole-3-acetaldehyde + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44146", "l": "CoA + H(+) + N(alpha)-acetyl-L-methionine => acetyl-CoA + L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0070279", "l": "vitamin B6 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53034", "l": "17beta-estradiol 2-O-(beta-D-glucuronate) + H(+) + UDP => 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12267", "l": "2',4,4',6'-tetrahydroxychalcone + H(+) + O2 <=> aureusidin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-606287", "l": "RSF complex binds the centromere (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24021", "l": "2-(N(omega)-L-arginino)succinate => fumarate + L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429732", "l": "multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15418", "l": "L-arogenate + NADP(+) => CO2 + L-tyrosine + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53266", "l": "2beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59673", "l": "D-maltotriose + O2 => D-maltotriono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18054", "l": "H2O + paraoxon => 4-nitrophenol + diethylphosphate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.2", "l": "\"Papain\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50560", "l": "acetyl-CoA + N-terminal L-methionyl-L-tryptophyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213248", "l": "Transport of antigen loaded MHC II molecules to surface (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18427", "l": "3-dehydroquinate + H(+) + NADPH => L-quinate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32434", "l": "(1R,4S)-menthone + H(+) + NADPH + O2 <=> (4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33632", "l": "ATP + CoA + octanoate => AMP + diphosphate + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-517705", "l": "p-S318,221-HuR binds mRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30191", "l": "15-cis-phytoene + plastoquinone-9 = 15,9'-di-cis-phytofluene + plastoquinol-9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693561", "l": "RAD51 binds BRCA2 at resected DNA DSBs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28217", "l": "[thioredoxin]-dithiol + prostaglandin H2 <=> [thioredoxin]-disulfide + prostaglandin F2alpha"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665871", "l": "ADRM1 binds 26S proteasome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1247960", "l": "Activation of p38 MAPK (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54252", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61040", "l": "(+)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] = (+)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.10", "l": "\"Chloride peroxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12895", "l": "prostaglandin E2 => prostaglandin H2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58486", "l": "acetate + sphing-4-enine => H2O + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213192", "l": "Hemidesmosome formation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16847", "l": "citrate + CoA + H(+) => acetyl-CoA + H2O + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008684", "l": "TBK1 phosphorylation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22199", "l": "(9Z,12Z)-octadecadienoyl-CoA + AH2 + O2 <=> (6Z,9Z,12Z)-octadecatrienoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112429", "l": "Formation of FACT complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977629", "l": "Displacement of C2a/Bb by CR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987043", "l": "IL22RA1 binds JAK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050363", "l": "tryptophan dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47066", "l": "4alpha-formyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62146", "l": "2 dGDP => dGMP + dGTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66691", "l": "4-farnesyl-3,5-dihydroxy-6-methylphthalide + AH2 + 2 O2 <=> (4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + A + acetone + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40258", "l": "(2E)-hexadecenedioyl-CoA + H2O <=> (3R)-hydroxyhexadecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-378975", "l": "Follitropin is a heterodimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33720", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-hexacosanoylsphinganine => a 1,2-diacyl-sn-glycerol + N-(hexacosanoyl)-sphinganine-1-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-167429", "l": "The receptor:G-protein complex  binds GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11857", "l": "1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850997", "l": "TRIM27 binds PTEN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44288", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CDP-choline = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1297275", "l": "CD9:Izumo Binding (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192123", "l": "CYP27A1 27-hydroxylates CHOL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685156", "l": "ATR phosphorylates RPA2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004640", "l": "phosphoribosylanthranilate isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352059", "l": "SLC6A15-mediated amino acid uptake (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198314", "l": "DAG stimulates protein kinase C-delta (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990175", "l": "EH domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25238", "l": "ATP + CDP => ADP + CTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6794347", "l": "Homer1,2,3 dimerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40052", "l": "chorismate => 3-[(1-carboxyvinyl)-oxy]benzoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40212", "l": "(3S)-hydroxytetradecanedioyl-CoA + NAD(+) => 3-oxotetradecanedioyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050123", "l": "N-acylmannosamine 1-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52838", "l": "H2O + indoxyl + NAD(+) => H(+) + indole + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51456", "l": "H2O + N-(9Z-octadecenoyl)-L-isoleucine = (9Z)-octadecenoate + L-isoleucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793978", "l": "Expression of STAT6-upregulated extracellular proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177284", "l": "PKA phosphorylates PDE4B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174235", "l": "Association of Emi1 with Cdc20 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66496", "l": "GDP-alpha-D-rhamnose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651773", "l": "LIG1 binds POLB at long-patch BER site (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11847", "l": "acetyl-CoA + formate <=> CoA + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32693", "l": "(E)-beta-ocimene + diphosphate => (2E)-geranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682010", "l": "ATG10:ATG12 binds ATG5 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39630", "l": "(3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA <=> (2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57857", "l": "(E)-feruloyl-CoA + 2-oxoglutarate + O2 => (E)-6-hydroxyferuloyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32821", "l": "chromate(out) => chromate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51622", "l": "CO2 + dCTP + H2O => CTP + formate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39076", "l": "(2E)-dodecenedioyl-CoA + H2O => (3S)-hydroxydodecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57531", "l": "5'-end ribonucleotide-RNA + a ribonucleoside 5'-triphosphate + ATP + H2O <=> 5'-phospho-ribonucleosidyl-ribonucleotide-RNA + AMP + 2 diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60633", "l": "all-trans-4-oxoretinol + NAD(+) => all-trans-4-oxoretinal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954117", "l": "E2F6:TFDP1 binds EPC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32940", "l": "a 1,2-diacyl-sn-glycerol + CDP-choline => a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50043", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O <=> 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32556", "l": "(2E)-geranyl diphosphate + H2O => (R)-alpha-terpineol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62897", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc + GDP-beta-L-fucose => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29256", "l": "Ca(2+)(in) + Na(+)(out) => Ca(2+)(out) + Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26224", "l": "abieta-7,13-dien-18-ol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> abieta-7,13-dien-18-oate + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003852", "l": "2-isopropylmalate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19174", "l": "H(+) + NADH + naphthalene + O2 => (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693608", "l": "Initial resection of double-strand break ends (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0070883", "l": "pre-miRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64860", "l": "(E)-5-hydroxyferuloyl-CoA + S-adenosyl-L-methionine = (E)-sinapoyl-CoA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57307", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP <=> glycolate + GMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39718", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + AH2 + O2 <=> (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.19", "l": "\"Tryptophan dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13386", "l": "3-oxododecanoate + H(+) => 2-undecanone + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45659", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+) <=> 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39328", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA => (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19050", "l": "(5R)-5-hydroxy-L-lysine + GTP => (5R)-5-phosphooxy-L-lysine + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690740", "l": "CD22 binds B-cell receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033509", "l": "USP9X binds Ub:PEX5L (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67023", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.75", "l": "\"Furin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10295", "l": "acetyl-CoA + D-glucosamine 6-phosphate <=> CoA + H(+) + N-acetyl-D-glucosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59067", "l": "demethylluteothin + S-adenosyl-L-methionine <=> luteothin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3134962", "l": "DHX36 binds DNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12334", "l": "ADP + Fe(3+)(in) + H(+) + phosphate => ATP + Fe(3+)(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27692", "l": "ADP + dGTP => ATP + dGDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23204", "l": "chlorogenate + D-glucarate = 2-O-caffeoylglucarate + L-quinate"}, {"i": "EC:2.3.1.98", "l": "\"Chlorogenate--glucarate O-hydroxycinnamoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32149", "l": "6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + H(+) => H2O + sepiapterin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54471", "l": "1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29152", "l": "3 a ubiquinol(in) + 2 H(+)(out) + nitrite(out) => 3 a ubiquinone(in) + 2 H2O(out) + NH4(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56540", "l": "(9Z)-octadecenoyl-CoA + 1,2-dihexanoyl-sn-glycerol = 1,2-dihexanoyl-3-(9Z-octadecenoyl)-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004134", "l": "4-alpha-glucanotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58939", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADH <=> all-trans-lycopaoctaene + 2 diphosphate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36952", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + heptadecanoyl-CoA + O2 => (9Z)-heptadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42164", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2 = (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40025", "l": "diphosphate + syn-copalol => 9alpha-copalyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57373", "l": "H2O + NADPH => (6S)-NADPHX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-741386", "l": "RIP2 induces K63-linked ubiquitination of NEMO (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1834951", "l": "IFI16 binds cytosolic dsDNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12554", "l": "(E)-pinosylvin + 4 CO2 + 4 CoA => (E)-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31297", "l": "2-oxopent-4-enoate => (2E)-2-hydroxypenta-2,4-dienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35534", "l": "cyclo(L-phenylalanyl-L-leucyl) + 2 O2 <=> albonoursin + 2 H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54269", "l": "2-oxoglutarate + L-asparaginyl-[hypoxia-inducible factor alpha subunit] + O2 => (3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha subunit] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64879", "l": "H2O + UDP <=> H(+) + phosphate + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49388", "l": "UDP-alpha-D-glucose + validoxylamine A = H(+) + UDP + validamycin A"}, {"i": "EC:2.4.1.338", "l": "\"Validoxylamine A glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20281", "l": "3'-phosphoadenylyl sulfate + desulfoglucotropeolin = adenosine 3',5'-bisphosphate + glucotropeolin + H(+)"}, {"i": "RHEA:52736", "l": "3'-phosphoadenylyl sulfate + indolylmethyl-desulfoglucosinolate = adenosine 3',5'-bisphosphate + glucobrassicin + H(+)"}, {"i": "EC:2.8.2.24", "l": "\"Aromatic desulfoglucosinolate sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0120250", "l": "fatty acid omega-hydroxylase activity"}, {"i": "RHEA:39023", "l": "an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936851", "l": "AHRR binds ARNT (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176956", "l": "Formation of GINS complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015129", "l": "lactate transmembrane transporter activity"}, {"i": "REACT:R-HSA-373867", "l": "BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Homo sapiens)"}, {"i": "REACT:R-HSA-373875", "l": "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3642203", "l": "Dimeric TGFB1 does not bind TGFBR2 MSI frameshift mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63261", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H(+) + NADH => 4-pyridoxate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19438", "l": "nicotinate + UDP-alpha-D-glucose => N-(beta-D-glucosyl)nicotinate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322427", "l": "Beta-catenin recruits CBP/p300 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37518", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA <=> 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36775", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}, {"i": "EC:2.4.1.309", "l": "\"UDP-Gal:alpha-L-Fuc-1,2-beta-Gal-1,3-alpha-GalNAc-1,3-alpha-GalNAc-diphosphoundecaprenol alpha-1,3-galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160874", "l": "HYAL1 hydrolyses (HA)50 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67141", "l": "L-cysteinyl-[NO transferase protein] + N(omega)-hydroxy-L-arginine + O2 => H(+) + H2O + L-citrulline + S-nitroso-L-cysteinyl-[NO transferase protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13144", "l": "2-methylpropanoyl-CoA <=> butanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39379", "l": "(2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H(+) + NADPH = (15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662986", "l": "MT2A binds copper (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37517", "l": "1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50050", "l": "ADP + cholate(out) + H(+) + phosphate => ATP + cholate(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9640195", "l": "RRAGA,B hydrolyzes GTP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956676", "l": "YAP1 binds TP73 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40176", "l": "O2 + octanoyl-CoA => (2E)-octenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112604", "l": "Phosphorylated STATs are released (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31049", "l": "CO2 + NADH + propanoyl-CoA => (S)-methylmalonate semialdehyde + CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66579", "l": "3'-phosphoadenylyl sulfate + 4-isopropylphenol <=> 4-isopropylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202604", "l": "Formation of a heteromeric BMP receptor complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863012", "l": "Calpain cleaves p35 to p25 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010190", "l": "ROBO3 binds NELL2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50512", "l": "acetyl-CoA + N-terminal L-cysteinyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0003682", "l": "chromatin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9008684", "l": "TBK1 phosphorylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008824", "l": "cyanate hydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45845", "l": "(3R)-hydroxyoctanoyl-CoA + NADP(+) => 3-oxooctanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296043", "l": "Activation of HCN channels (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158137", "l": "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682967", "l": "WHSC1 binds DNA DSBs (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30190", "l": "(S)-dihydroorotate + a quinone <=> a quinol + orotate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034838", "l": "menthone dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-112395", "l": "Abortive termination of elongation after arrest (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38334", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2327733", "l": "FN1 binds Collagen types I-V, VII (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17848", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) <=> 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944246", "l": "Association of procollagen type XXI (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-383190", "l": "HCO3- transport through ion channel (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018863", "l": "phenanthrene-9,10-epoxide hydrolase (9S,10S-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48870", "l": "AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide => H2O + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41399", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine <=> 1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062064", "l": "box C/D snoRNP complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158849", "l": "Phenol can form a sulfate conjugate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008587", "l": "IL37, IL37(?-218) binds IL18BP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16871", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937814", "l": "RUNX3 translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190141", "l": "ALAD binds to Pb2+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730885", "l": "Recruitment of TEC kinases to p-SLP-76 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39173", "l": "(3R)-hydroxyeicosanoyl-CoA + NADP(+) => 3-oxoeicosanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50859", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451634", "l": "NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018616", "l": "trihydroxytoluene dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17068", "l": "(R)-mevalonate + ATP <=> (R)-5-phosphomevalonate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61762", "l": "rebaudioside A + UDP => rebaudioside B + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2288097", "l": "Condensin II complex binds H4K20me1-containing nucleosomes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.28"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801687", "l": "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0030613", "l": "oxidoreductase activity, acting on phosphorus or arsenic in donors"}, {"i": "EC:1.20.-.-", "l": "\"Acting on phosphorus or arsenic in donors\""}]}
{"type": "biolink:MolecularActivity", "ic": "80.155824608458104", "identifiers": [{"i": "GO:0070063", "l": "RNA polymerase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46944", "l": "(S)-2-amino-6-oxohexanoate + holo-[LYS2 peptidyl-carrier protein] + NADP(+) = H(+) + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549060", "l": "NrCAM binds Neuropilin-2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74885", "l": "GUCYs converts GTP to cGMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928631", "l": "GIT1 binds bPIX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9680443", "l": "ROCK1,2 bind ROCKi (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23388", "l": "ATP + hygromycin B = 7''-O-phosphohygromycin B + ADP + H(+)"}, {"i": "EC:2.7.1.119", "l": "\"Hygromycin-B 7''-O-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51313", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389532", "l": "PP2A binds CTLA4 dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44492", "l": "3,4-dihydroxy-5-all-trans-decaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202692", "l": "PIP3 binds to RhoA and activates it (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570528", "l": "SUMOylation of XPC with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64898", "l": "2 H(+) + 2 phosphate + UMP => 2 H2O + UTP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008775", "l": "acetate CoA-transferase activity"}, {"i": "RHEA:13381", "l": "acetate + an acyl-CoA = a carboxylate + acetyl-CoA"}, {"i": "EC:2.8.3.8", "l": "\"Acetate CoA-transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334794", "l": "FABPs bind LCFAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674093", "l": "PDGFRs bind type I TKI (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391936", "l": "EP1 receptor can bind PGE2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3296233", "l": "T2Rs bind bitter-tasting compounds (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41049", "l": "1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65943", "l": "(R)-glycerate + GDP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53904", "l": "ATP + L-threonyl-[tau protein] = ADP + H(+) + O-phospho-L-threonyl-[tau protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53805", "l": "allodeoxycholoyl-CoA + ursodeoxycholate => allodeoxycholate + ursodeoxycholoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57158", "l": "4-hydroxy-L-lysyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-lysyl-[protein] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43126", "l": "2 H(+) + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine => guanosine(10) in tRNA + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17539", "l": "(R)-carnitine + NH4(+) => (R)-carnitinamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34269", "l": "CoA + fumigaclavine A => acetyl-CoA + fumigaclavine B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2219524", "l": "PDPK1 binds PIP2 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33557", "l": "(4R)-hydroxysphinganine + a fatty acid => an N-acyl-(4R)-4-hydroxysphinganine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33263", "l": "L-phenylalanine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-phenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.40", "l": "\"Phenylalanine N-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25325", "l": "N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine = H(+) + phosphocholine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24485", "l": "NAD(+) + sulcatol => H(+) + NADH + sulcatone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070087", "l": "chromo shadow domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8939204", "l": "ESTG binds ESR1:chaperone complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198669", "l": "p38MAPK phosphorylates MSK1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2468040", "l": "Cohesin binds PDS5 and WAPAL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46370", "l": "2 [Fe(III)-cytochrome b5] + a (9Z,11E,13E)-octadecatrienoyl-containing glycerolipid + 2 H2O => 2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-199839", "l": "AKT can phosphorylate RSK (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14195", "l": "2,3-dihydroxybenzoate + A + H2O => 3-hydroxybenzoate + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211904", "l": "CYP4F12 18-hydroxylates ARA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426155", "l": "SREBP1A,2 binds the DHCR7 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045028", "l": "G protein-coupled purinergic nucleotide receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685156", "l": "ATR phosphorylates RPA2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20074", "l": "D-allothreonine => acetaldehyde + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13039", "l": "ITP + NH4(+) => ATP + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.21", "l": "\"Rhizopuspepsin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195304", "l": "Association of beta-catenin with the destruction complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031822", "l": "type 1B serotonin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40686", "l": "1-hexadecanoylglycerone 3-phosphate + dodecan-1-ol <=> 1-O-dodecylglycerone 3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49439", "l": "cholate + deoxycholoyl-CoA <=> choloyl-CoA + deoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018636", "l": "phenanthrene 9,10-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205262", "l": "Direct recruitment of PI3K to p-KIT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17614", "l": "NAD(+) + scyllo-inositol => H(+) + NADH + scyllo-inosose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032115", "l": "sorbose reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54093", "l": "3,4-dihydroxyphenylacetate + H(+) + NADPH + O2 => 2,4,5-trihydroxyphenylacetate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63018", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + NH4(+) => (5Z,8Z,11Z,14Z)-eicosatetraenamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46320", "l": "3beta-hydroxy-chol-5-ene-24-oyl-CoA + A = 3beta-hydroxy-chol-5,22-dien-24-oyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12735", "l": "5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate => CO2 + diphosphate + nicotinate beta-D-ribonucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-392749", "l": "Transport of L1 into endosomes (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784734", "l": "PCSK9 binds LDLR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029454", "l": "Autophosphorylation of PAK1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16625", "l": "acetyl-CoA + hydrogen sulfide = CoA + thioacetate"}, {"i": "EC:2.3.1.10", "l": "\"Hydrogen-sulfide S-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26020", "l": "beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + H2O => beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23769", "l": "a fatty acyl-CoA + sphing-4-enine => an N-acylsphing-4-enine + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13058", "l": "an N-acylneuraminate 9-phosphate + H2O => an N-acylneuraminate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448427", "l": "Interleukin-27 binds Interleukin-27 receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24424", "l": "2 glutathione + L-dehydroascorbate = glutathione disulfide + L-ascorbate"}, {"i": "EC:1.8.5.1", "l": "\"Glutathione dehydrogenase (ascorbate)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31280", "l": "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate => (2Z,6E,10E)-geranylgeranyl diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687107", "l": "MAPK4,6 translocate to nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052832", "l": "inositol monophosphate 3-phosphatase activity"}, {"i": "RHEA:30739", "l": "1D-myo-inositol 3-phosphate + H2O = myo-inositol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38822", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211206", "l": "Translocation of DFF to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084910", "l": "Collagen type II binds integrin alpha2beta1, alpha1beta1, alpha11beta1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186741", "l": "SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37150", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43008", "l": "D-serine = 2-aminoprop-2-enoate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038147", "l": "C-X-C motif chemokine 12 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9028730", "l": "Activated NTRK2 binds FRS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47514", "l": "isocholate + NAD(+) => 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30205", "l": "2 GDP + 2 H(+) => H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29164", "l": "2 H(+)(out) + 3 menaquinol-8(in) + nitrite(out) => 2 H2O(out) + 3 menaquinone-8(in) + NH4(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102322", "l": "2-propylphenol monooxygenase activity"}, {"i": "RHEA:63524"}, {"i": "MetaCyc:RXN-13151"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31970", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-11beta-hydroxycassa-12,15-diene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10487", "l": "H2O + N-feruloylglycine <=> (E)-ferulate + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64792", "l": "L-lysine + NADP(+) = 2 H(+) + L-1-piperideine-6-carboxylate + NADPH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730835", "l": "Autophosphorylation of PKC-theta (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60000", "l": "hydroxymethylphosphonate + O2 = formate + 2 H(+) + phosphate"}, {"i": "EC:1.13.11.89", "l": "\"(Hydroxymethyl)phosphonate dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.n2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58078", "l": "(11Z)-eicosenoate + glycerol + H(+) => 1-(11Z-eicosenoyl)-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140111", "l": "[choline trimethylamine-lyase]-activating enzyme activity"}, {"i": "MetaCyc:RXN-16470"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14966", "l": "an acyl phosphate + H2O => a carboxylate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879459", "l": "F-actin capping protein is a heterodimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0001882", "l": "nucleoside binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68849", "l": "Mcm2-7 associates with the Cdt1:CDC6:ORC:origin complex, forming the pre-replicative complex (preRC) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28867", "l": "H(+)(in) + lactose(in) = H(+)(out) + lactose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166726", "l": "Activation of MASPs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23389", "l": "ATP + hygromycin B => 7''-O-phosphohygromycin B + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062145", "l": "L-propargylglycine--L-glutamate ligase activity"}, {"i": "RHEA:59896", "l": "ATP + L-glutamate + L-propargylglycine = ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32789", "l": "ADP + H(+) + L-ectoine(in) + phosphate => ATP + H2O + L-ectoine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849797", "l": "Membrane proteases cleave Profilaggrin producing Filaggrin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54481", "l": "1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83677", "l": "C4 deamination of cytidine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450488", "l": "BRF1 Complex recruits RNA degradation activities (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19278", "l": "ATP + L-pyrrolysine + tRNA(Pyl) => AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987223", "l": "IL10RB binds TYK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093342", "l": "SDC2 multimerises (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71825", "l": "G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102744", "l": "all-trans-geranyl-geranyl diphosphate reductase activity"}, {"i": "MetaCyc:RXN-7658"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63928", "l": "2 [Fe(II)-cytochrome b5] + an N-acylsphing-4-enine + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + an N-acyl-sphinga-4E,14Z-dienine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30564", "l": "dimethylallyl diphosphate + L-tryptophan => 7-(3-methylbut-2-enyl)-L-tryptophan + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0031127", "l": "alpha-(1,2)-fucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17486", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445079", "l": "Phosphorylation of L1 by ERK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176942", "l": "Multiple proteins are localized at replication fork (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655170", "l": "RCHY1 monoubiquitinates POLH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445367", "l": "CaMKII binds activated NMDA receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980056", "l": "JAG1 binds NOTCH2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13018", "l": "diphosphate + UMP => 5-phospho-alpha-D-ribose 1-diphosphate + uracil"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710914", "l": "ALK fusions bind GRB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050627", "l": "mycothione reductase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018570", "l": "p-cumate 2,3-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64120", "l": "an N-(fatty acyl)-L-serine + H2O = a fatty acid + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48541", "l": "1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O => dodecanoate + dodecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58122", "l": "3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate => ATP + L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170965", "l": "(Frs2)Rap1-GTP binds to and activates B-Raf (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786500", "l": "ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004855", "l": "xanthine oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879925", "l": "SHC1 bound to the common beta chain becomes tyrosine phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29105", "l": "4 H(+)(out) + menaquinol-8 + NAD(+) => 5 H(+)(in) + menaquinone-8 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694568", "l": "Nucleoprotein translocates to the ERGIC outer membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371591", "l": "Trimerization of cytosolic HSF1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031510", "l": "Expression of APOC1 regulated by NR1H2 or NR1H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45448", "l": "H2O + N-(dodecanoyl)-sphinganine = dodecanoate + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388831", "l": "Phosphorylation of CD28 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034541", "l": "dimethylarsinite methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651789", "l": "LIG1 bound to POLB ligates SSB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607733", "l": "BCL10 binds CARD9 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28885", "l": "H(+)(out) + L-threonine(out) => H(+)(in) + L-threonine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57850", "l": "CO2 + fraxetin + succinate => 2-oxoglutarate + O2 + scopoletin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47427", "l": "(2E,9Z)-octadecadienoyl-CoA + H2O <=> (3S)-hydroxy-(9Z-octadecenoyl)-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807585", "l": "BPI binds LPS on the bacterial surface (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373738", "l": "Neurofascin interacts with syntenin-1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20635", "l": "a lyso-ornithine lipid + H(+) + holo-[ACP] => a (3R)-hydroxyacyl-[ACP] + L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38388", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1,3-di-(9Z-octadecenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15538", "l": "(R)-3-sulfolactate + NADP(+) => 3-sulfopyruvate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354066", "l": "Translocation of PTK2 to Focal complexes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804276", "l": "ATM phosphorylates TTC5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22743", "l": "ATP + D-hexose <=> ADP + D-hexose 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389532", "l": "PP2A binds CTLA4 dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050012", "l": "juglone 3-hydroxylase activity"}, {"i": "RHEA:18745", "l": "2 juglone + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+)"}, {"i": "EC:1.17.3.4", "l": "\"Juglone 3-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445072", "l": "Interaction of PAK1 with Rac1-GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20654", "l": "23,24-dihydrocucurbitacin B + NAD(+) => cucurbitacin B + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27735", "l": "4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O => 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-606326", "l": "HJURP:CENPA complex localizes to the centromere (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13174", "l": "H2O + NAD(+) + phosphonate => H(+) + NADH + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23304", "l": "atropine + H2O = H(+) + tropate + tropine"}, {"i": "EC:3.1.1.10", "l": "\"Tropinesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-450975", "l": "isocitrate <=> citrate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50570", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61466", "l": "a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in mRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982637", "l": "Opsins binds G alpha-t (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615249", "l": "ARBs bind AGRT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43276", "l": "ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GalNAc-GD1a + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443778", "l": "Interaction of L1 with Laminin-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53997", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797554", "l": "ABP1 binds SHANK proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52605", "l": "3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-seryl-[protein] + ATP => 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-seryl-[protein] + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46688", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA + A = 3-oxo-cholest-4,24-dien-26-oyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936951", "l": "Activation of TAK1 complex bound to activated TLR4 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20981", "l": "2 bilirubin IXalpha + O2 => 2 biliverdin IXalpha + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17900", "l": "A + ethylbenzene + H2O <=> (S)-1-phenylethanol + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54182", "l": "a long-chain fatty acyl-[ACP] + H(+) + NADH => a long-chain fatty aldehyde + holo-[ACP] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36507", "l": "docosanoyl-CoA + H(+) + malonyl-CoA = 3-oxotetracosanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864569", "l": "WWOX binds TFAP2C (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22369", "l": "L-ribulose 5-phosphate => D-xylulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41759", "l": "1-O-methyl-(9Z,12Z)-octadecadienoate + O2 <=> 1-O-methyl-(13S)-hydroperoxy-(9Z,11E)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350486", "l": "DSH binds to FZ at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52113", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA => 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18545", "l": "2-dehydro-3-deoxy-L-arabinonate = glycolaldehyde + pyruvate"}, {"i": "EC:4.1.2.18", "l": "\"2-dehydro-3-deoxy-L-pentonate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56227", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12310", "l": "2 H(+) + L-2-aminoadipate + NADH => (S)-2-amino-6-oxohexanoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52249", "l": "6 H2O + 4 Mn(3+) + O2 => 12 H(+) + 4 MnO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60713", "l": "(+)-artemisinic alcohol + NAD(+) => (+)-artemisinic aldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373716", "l": "DCC interacting NCK-1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954082", "l": "E2F6 binds the PRC1 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65960", "l": "ATP + H2O + leukotriene C4(out) = ADP + H(+) + leukotriene C4(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17343", "l": "1-hexadecanoylglycerone 3-phosphate + H(+) + NADPH => 1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944225", "l": "Association of procollagen type XVII (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046175", "l": "Further sulfation on galactose residues produces KSPG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139898", "l": "Caspase-8 activates BID by cleavage (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74716", "l": "Insulin binds the insulin receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944227", "l": "Association of procollagen type XXII (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23150", "l": "ADP + propanoyl phosphate => ATP + propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102866", "l": "di-homo-gamma-linolenate delta5 desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49377", "l": "12-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 12,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36322", "l": "2 H(+) + 2 NADPH + octadecanoyl-CoA <=> CoA + 2 NADP(+) + octadecan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20718", "l": "NH4(+) + S-inosyl-L-homocysteine => H(+) + H2O + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983696", "l": "The Immunoglobulin of the BCR binds antigen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6805205", "l": "GPR35 binds kynurenic acid (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682769", "l": "LGI2 binds ADAM22,23 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8960973", "l": "RLBP1:11cRAL dissociates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54824", "l": "H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein] = alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)"}, {"i": "EC:3.2.1.130", "l": "\"Glycoprotein endo-alpha-1,2-mannosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209178", "l": "N-HH binds to PTC receptor complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810376", "l": "ING2 binds PI5P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "55.737942431277602", "identifiers": [{"i": "GO:0005102", "l": "signaling receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9022314", "l": "HIPK2 phosphorylates MECP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21436", "l": "[translation elongation factor 2] + ATP = [translation elongation factor 2]-phosphate + ADP + H(+)"}, {"i": "EC:2.7.11.20", "l": "\"[Elongation factor 2] kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23168", "l": "coformycin + NADP(+) = 8-oxocoformycin + H(+) + NADPH"}, {"i": "EC:1.1.1.235", "l": "\"8-oxocoformycin reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26138", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54761", "l": "ATP + H(+) + pyridinium-3,5-dicarboxylate mononucleotide => 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13972", "l": "(RNA)-3'-(3'-phosphooxy-ribonucleotide) + GTP <=> (RNA)-3'-(2',3'-cyclophosphooxy)-ribonucleotide + diphosphate + GMP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080071", "l": "indol-3-yl-methyl-desulfoglucosinolate sulfotransferase activity"}, {"i": "MetaCyc:RXN-1443"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480301", "l": "Expression of EPAS1 (HIF2A) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196026", "l": "Dab2 is recruited to the junctional plaques (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853793", "l": "p-5Y-RET complexes bind GRB2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706330", "l": "Active FLT3 binds to SOCS6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10029", "l": "D-glutamate + H2O + O2 => 2-oxoglutarate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21114", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose => globoside Gb3Cer (d18:1(4E)) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18078", "l": "L-arginyl-[dinitrogen reductase] + NAD(+) => H(+) + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29625", "l": "alpha-maltohexaose + beta-D-glucose => alpha-maltopentaose + beta-maltose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404134", "l": "RBP4:atROL binds TTR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11824", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate"}, {"i": "EC:2.1.2.11", "l": "\"3-methyl-2-oxobutanoate hydroxymethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939204", "l": "ESTG binds ESR1:chaperone complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57597", "l": "(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-2-hydroxyeriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34809", "l": "camalexin + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (R)-dihydrocamalexate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33887", "l": "(-)-secoisolariciresinol + 2 NAD(+) = (-)-matairesinol + 2 H(+) + 2 NADH"}, {"i": "EC:1.1.1.331", "l": "\"Secoisolariciresinol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46235", "l": "(9Z,12Z)-hexadecadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z,15Z)-hexadecatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250607", "l": "botD HC:LC binds SV2A or B or C and GD2 on the target cell surface (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0070001", "l": "aspartic-type peptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35020", "l": "L-threonine(in) => L-threonine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22143", "l": "a nucleoside 5'-phosphate + H2O <=> a nucleoside + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69005", "l": "Cdc6 protein is phosphorylated by CDK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799466", "l": "TP53I3 dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51353", "l": "H2O + N-(9Z-octadecenoyl)-L-serine => (9Z)-octadecenoate + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59712", "l": "D-maltotetraono-1,5-lactone + H2O = D-maltotetraonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55105", "l": "3-oxoheptanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyheptanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32593", "l": "(3R,6S)-6-hydroxy-3,7-dimethyloctanoate + H(+) => (4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68849", "l": "Mcm2-7 associates with the Cdt1:CDC6:ORC:origin complex, forming the pre-replicative complex (preRC) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32924", "l": "H2O + sn-glycero-3-phospho-(1'-sn-glycerol) => glycerol + H(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36013", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41570", "l": "aclacinomycin S + dTDP + H(+) => aclacinomycin T + dTDP-2-deoxy-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200396", "l": "Creatine transport across the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684275", "l": "nsp3-4 is glycosylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16710", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428752", "l": "Dissociation of the TP:Gq complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.-", "l": "\"Miscellaneous\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48961", "l": "[thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide => [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53580", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43581", "l": "A + D-arginine => AH2 + iminoarginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32526", "l": "nigerose + phosphate <=> beta-D-glucose 1-phosphate + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875568", "l": "RAPGEF1 activates RAP1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65044", "l": "4-cyanobenzyl alcohol + NAD(+) = 4-cyanobenzaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63575", "l": "H2O + neurotensin-(1-8) <=> L-arginine + neurotensin-(1-7)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56261", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP-alpha-D-galactose => 4 H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209049", "l": "Phosphorylation of AXN and APC by SGG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33665", "l": "2 [Fe(III)-cytochrome b5] + H2O + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine => 2 [Fe(II)-cytochrome b5] + 2 H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44291", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CDP-choline <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950608", "l": "Expression U2 small nuclear ribonucleoprotein A' (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56951", "l": "pyruvate + UTP <=> H(+) + phosphoenolpyruvate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51927", "l": "AH2 + menaquinone-9 <=> A + beta-dihydromenaquinone-9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805035", "l": "TP53 binds STK11 and NUAK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106009", "l": "(4S)-4-hydroxy-2-oxoglutarate aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35684", "l": "hexadecasphinganine + NADP(+) => 3-oxohexadecasphinganine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047108", "l": "(R)-3-hydroxyacid-ester dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659998", "l": "Defective TALDO1 does not transform Fru(6)P, E4P to SH7P, GA3P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033699", "l": "DNA 5'-adenosine monophosphate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23662", "l": "N-formimidoyl-L-glutamate => 4-imidazolone-5-propanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51627", "l": "formate + GTP + H(+) <=> CO2 + dGTP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418200", "l": "SRC-1 bound to ARRB2 is not activated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57451", "l": "ATP + D-tyrosine + tRNA(Tyr) <=> AMP + D-tyrosyl-tRNA(Tyr) + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49314", "l": "2-trans-(+)-abscisic aldehyde + H(+) + NADH => 2-trans,4-trans-xanthoxin + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28377", "l": "ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033879", "l": "acetylajmaline esterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622363", "l": "CEBPA binds the promoter of the KLF5 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20543", "l": "2 H2O + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+) => H(+) + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44141", "l": "CoA + 2 H(+) + oxidized [flavodoxin] + pyruvate => acetyl-CoA + CO2 + reduced [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199093", "l": "CXADR binds to AMICA1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51860", "l": "(2E)-geranyl diphosphate + umbelliferone = 8-geranylumbelliferone + diphosphate"}, {"i": "RHEA:51864", "l": "(2E)-geranyl diphosphate + esculetin = 8-geranylesculetin + diphosphate"}, {"i": "EC:2.5.1.138", "l": "\"Coumarin 8-geranyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51813", "l": "ATP(in) + CoA(in) + H(+)(out) + tetradecanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + tetradecanoyl-CoA(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625479", "l": "SRF and ELK1 bind the FOS gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58428", "l": "(E,E)-2,4-hexadien-1-ol + NADP(+) = (E,E)-2,4-hexadienal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977071", "l": "Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61960", "l": "2 [Fe(II)-cytochrome b5] + a 1-O-hexadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a 1-O-(1Z-hexadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19841", "l": "H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.2.7.12", "l": "\"Formylmethanofuran dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53500", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39015", "l": "22-oxodocosanoate + H2O + NAD(+) = docosanedioate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864595", "l": "TFAP2B homodimer binds YEATS4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592278", "l": "Autocatalytic activation of proMMP2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805638", "l": "KAT6A acetylates TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66049", "l": "2-oxobutanoate + L-kynurenine => (2S)-2-aminobutanoate + 4-(2-aminophenyl)-2,4-dioxobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32239", "l": "gamma-carotene = all-trans-beta-carotene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5632738", "l": "DDIT4 binds 14-3-3 dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57886", "l": "H(+) + Na(+)(out) + 2 phosphate => diphosphate + H2O + Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56872", "l": "(S)-N-acetyl-1-phenylethylamine + H2O = (S)-1-phenylethylamine + acetate"}, {"i": "EC:3.5.1.85", "l": "\"(S)-N-acetyl-1-phenylethylamine hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3788061", "l": "Fibronectin degradation by ADAM8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18298", "l": "a phtalamide + H2O => a primary amine + phthalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164151", "l": "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0140412", "l": "zinc:bicarbonate symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709360", "l": "H2O2 reduces MetHb (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.90"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222485", "l": "TrxB reactivates TrxA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56285", "l": "a (3R,4R)-4,2'-dihydroxyisoflavan + NADP(+) => a (3R)-2'-hydroxyisoflavanone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14284", "l": "2 [Fe(III)cytochrome c] + H2O + sulfite <=> 2 [Fe(II)cytochrome c] + 2 H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48992", "l": "1,3,7-trimethylurate + H(+) + NADH + O2 = 1,3,7-trimethyl-5-hydroxyisourate + H2O + NAD(+)"}, {"i": "EC:1.14.13.212", "l": "\"1,3,7-trimethyluric acid 5-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218824", "l": "p-6Y-VEGFR2 binds FYN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70272", "l": "PGM:Mg2+ isomerise G6P to G1P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.50", "l": "\"Alpha-N-acetylglucosaminidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202726", "l": "F11R dimerises (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56926", "l": "ADP + H(+) + O-phospho-L-threonyl-[Goodpasture antigen-binding protein] => ATP + L-threonyl-[Goodpasture antigen-binding protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64686", "l": "3-O-(alpha-D-glucosyl)-L-threonyl-[protein] + H(+) + UDP => L-threonyl-[protein] + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38995", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5660980", "l": "p-S276-RELA binds RELB (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36285", "l": "7-methylxanthine + formaldehyde + H2O + NADP(+) => 1,7-dimethylxanthine + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36596", "l": "hydrogen sulfide + NADP(+) => NADPH + sulfur"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943080", "l": "TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213239", "l": "Formation of MHC II alpha beta heterodimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47602", "l": "CMP + ganglioside GM4 (d18:1(4E)) + H(+) => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41476", "l": "5alpha-cholesta-8,24-dien-3beta-ol + an acyl-CoA = CoA + zymosterol ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.96"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428231", "l": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430347", "l": "MigFilin associates with Filamin and F-actin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60438", "l": "3-methylbutanol + acetate + H(+) => 3-methylbutyl acetate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40046", "l": "ATP + citrate + L-glutamate <=> ADP + beta-citrylglutamate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982017", "l": "Active G alpha (q) binds RGS proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418091", "l": "F2R binds ARRB1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416683", "l": "SEMA3E binds to PLXND1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375133", "l": "Basigin binds Mannose-carrying cell recognition molecules (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29742", "l": "ATP + beta-maltose(out) + H2O <=> ADP + beta-maltose(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77607", "l": "Formation of stem-loop structure in ApoB mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58942", "l": "all-trans-lycopaoctaene + diphosphate + NAD(+) => (1R,2R,3R)-prephytoene diphosphate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070540", "l": "stearic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32092", "l": "3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine => dTDP + erythromycin D + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53831", "l": "2-oxoglutarate + a 5-hydroxymethyl-2'-deoxycytidine in DNA + O2 <=> a 5-formyl-2'-deoxycytidine in DNA + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080115", "l": "myosin XI tail binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102801", "l": "anthocyanin 5-O-glucoside-4'''-O-malonyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5226979", "l": "ADD1:ADD2 binds DMTN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797090", "l": "CCNK binds CDK12 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0003725", "l": "double-stranded RNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25743", "l": "H(+) + N,N-dihydroxy-L-pentahomomethionine = (E)-8-(methylsulfanyl)octanal oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48177", "l": "decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56547", "l": "H2O + N-hexadecanoyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55463", "l": "11-hydroxyferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 11-hydroxysugiol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730842", "l": "PI3K associates with phosphorylated GAB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30353", "l": "5-hydroxypyrrole-2-carboxylate + H2O + NAD(+) => H(+) + NADH + O2 + pyrrole-2-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63441", "l": "(2R)-3-phosphoglycerate + GTP + H(+) => 3-[(R)-glyceryl]-diphospho-5'-guanosine + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40942", "l": "1-O-hexadecylglycerone 3-phosphate + H(+) + NADPH <=> 1-O-hexadecyl-sn-glycero-3-phosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32869", "l": "myo-inositol(in) => myo-inositol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983427", "l": "Expression of peptide bound class I MHC on cell surface (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19349", "l": "(R)-4-dehydropantoate + H2O + NAD(+) = (R)-3,3-dimethylmalate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.33", "l": "\"(R)-dehydropantoate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17636", "l": "a beta-D-glucuronoside + H2O <=> an alcohol + D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57570", "l": "7-deoxyloganetic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 7-deoxyloganetic alcohol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33463", "l": "episterol + H(+) + NADPH + O2 = ergosta-5,7,24(28)-trien-3beta-ol + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706315", "l": "Active FLT3 binds to SH2B3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700120", "l": "PTN and MDK bind to PTPRZ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681616", "l": "AP2 binds chlorpromazine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034511", "l": "U3 snoRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203700", "l": "eNOS translocation from Golgi to Caveolae (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41300", "l": "H2O + N-(9Z-octadecenoyl)-sphing-4-enine => (9Z)-octadecenoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63047", "l": "H2O + mevastatin <=> H(+) + mevinic carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983688", "l": "OAS1 oligomerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32220", "l": "all-trans-lycopene => gamma-carotene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807578", "l": "GNLY binds the bacterial cell surface in the phagosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23494", "l": "UDP-alpha-D-galactosamine => UDP-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63848", "l": "2 2',3,4-trihydroxy-trans-chalcone + 2 H(+) + O2 = 2 3',4'-dihydroxyaurone + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54212", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2 = 2-(prostaglandin G2)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64969", "l": "dUTP + H2O => dUDP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106328", "l": "acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800794", "l": "PIDD1 associates with CRADD (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25028", "l": "H(+) + H2O + S-methyl-5'-thioadenosine <=> NH4(+) + S-methyl-5'-thioinosine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019149", "l": "3-chloro-D-alanine dehydrochlorinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57135", "l": "L-ascorbate + O2 + tyramine <=> (2R)-1-(4-hydroxyphenyl)-2-aminoethanol + H2O + L-dehydroascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49426", "l": "ADP + H(+) + validone 7-phosphate => ATP + validone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227783", "l": "Phosphorylation of IKKs complex mediated by MEKK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684250", "l": "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102952", "l": "UDP-glucose:coniferaldehyde 4-beta-D-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865505", "l": "SPI1 (PU.1) gene transcription is stimulated by RUNX1:CBFB:KMT2A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.3.5", "l": "\"Prenylcysteine oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042014", "l": "interleukin-19 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56542", "l": "1,2-dihexanoyl-3-(9Z-octadecenoyl)-sn-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1,2-dihexanoyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211948", "l": "CYP3A4 can N-demethylate loperamide (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10786", "l": "CO2 + formaldehyde + L-lysyl(36)-[histone H3] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl(36)-[histone H3] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27603", "l": "(2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate => di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004198", "l": "calcium-dependent cysteine-type endopeptidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0015573", "l": "beta-glucoside transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57122", "l": "1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45944", "l": "12-methyltridecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(13-methyl-2-oxotetradecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45367", "l": "H2O + N-(11Z-eicosenoyl)-(4R)-hydroxysphinganine <=> (11Z)-eicosenoate + (4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028598", "l": "Phosphorylation of YAP by LATS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789042", "l": "Hydroxyl-initiated lipid peroxidation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204873", "l": "Interaction of Tie2 and Shp2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36968", "l": "(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12235", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+) <=> [thioredoxin]-dithiol + glycine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62008", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose = alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17810", "l": "Mg-protoporphyrin IX + S-adenosyl-L-methionine => Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451895", "l": "IL2RG binds JAK3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25639", "l": "2 H(+) + NADH + sulfoacetate => H2O + NAD(+) + sulfoacetaldehyde"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010308", "l": "acireductone dioxygenase (Ni2+-requiring) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16739", "l": "(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) => H(+) + NADH + O2 + toluene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12308", "l": "(S)-2-amino-6-oxohexanoate + H2O + NAD(+) = 2 H(+) + L-2-aminoadipate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201708", "l": "Frizzled receptors bind Wnts (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57610", "l": "3-chlorocatechol + H(+) + NADH => (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53832", "l": "2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 = a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391935", "l": "DP1 receptor can bind PGD2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2179413", "l": "Activated PKC-alpha  activate MMP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50745", "l": "2 glyphosate + O2 => 2 aminomethylphosphonate + 2 glyoxylate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27651", "l": "GTP + uridine => GDP + H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68611", "l": "Formation of ORC(1-5) complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32569", "l": "(1R,4S)-camphene + diphosphate => (2E)-geranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64057", "l": "(1S,2R)-ephedrine + NAD(+) => (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39306", "l": "(3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA <=> (2E,11Z,14Z)-eicosatrienoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451511", "l": "TLR15 binds to recognized ligand (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444647", "l": "C3a receptor binds anaphylatoxin C3a (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23060", "l": "a (2R,3S)-2-alkyl-3-hydroxyalkanoate + ATP = a cis-3-alkyl-4-alkyloxetan-2-one + AMP + diphosphate"}, {"i": "EC:6.1.3.1", "l": "\"Olefin beta-lactone synthetase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25363", "l": "3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NAD(+) = H(+) + momilactone A + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018808", "l": "trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate hydratase-aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679028", "l": "JAK3 binds JAK3 inhibitors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615554", "l": "MIR137 gene expression is inhibited by MECP2 and SOX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004729", "l": "oxygen-dependent protoporphyrinogen oxidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003836", "l": "beta-galactoside (CMP) alpha-2,3-sialyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429699", "l": "CERT [ER] + ceramide [ER] => CERT:ceramide [ER] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418091", "l": "F2R binds ARRB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901680", "l": "sulfur-containing amino acid secondary active transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985950", "l": "p-Y649-STAT5A, p-STAT5B dimerizes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22171", "l": "UDP-alpha-D-glucose <=> UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56855", "l": "reumycin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + toxoflavin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51814", "l": "AMP(in) + diphosphate(in) + H(+)(in) + tetradecanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + tetradecanoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448632", "l": "IL34 dimerizes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54624", "l": "2-oxoglutarate + O2 + octadecanoyl-CoA = 2-hydroxyoctadecanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112690", "l": "PTPN11 binds CBL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445085", "l": "Phosphorylation of VAV2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63281", "l": "a 1-acyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 => a 1-acyl-2-(15-hydroperoxy-8Z,11Z,13E-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44435", "l": "2 a 1-acylglycerol <=> a 1,2-diacylglycerol + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.24", "l": "\"Ribonuclease T(1)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41799", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoylsphinganine <=> a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085992", "l": "SUMOylation of DAXX with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216048", "l": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5336443", "l": "LIN7, CASK and APBA1 bind (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64228", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59018", "l": "CO2 + cycloeucalenone + NADH => 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033925", "l": "mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418662", "l": "Src activation following P2Y purinoceptor activation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015421", "l": "ABC-type oligopeptide transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950778", "l": "p-Y693-STAT4 dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40760", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoylglycerone 3-phosphate => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerone 3-phosphate + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63039", "l": "H2O + octadecanamide <=> NH4(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64623", "l": "(E)-sinapoyl alcohol + acetyl-CoA <=> (E)-sinapoyl actetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55455", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> daturadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.39", "l": "\"Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11575", "l": "FAD + H(+) + H2O + lithocholate <=> chenodeoxycholate + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952069", "l": "HDAC4 deacetylates RUNX3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52593", "l": "deoxycholoyl-CoA + NAD(+) => 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20105", "l": "ADP + beta-D-fructose 6-phosphate = AMP + beta-D-fructose 1,6-bisphosphate + H(+)"}, {"i": "EC:2.7.1.146", "l": "\"ADP-specific phosphofructokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25368", "l": "3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NADP(+) => H(+) + momilactone A + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50162", "l": "N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45395", "l": "H2O + N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-eicosanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31361", "l": "ammoniodiacetate + FMN + glyoxylate + H2O => FMNH2 + nitrilotriacetate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786101", "l": "IL4 binds IL4R:JAK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050194", "l": "phosphonoacetaldehyde hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56475", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 <=> (5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13768", "l": "bromochloromethane + H2O <=> bromide + chloride + formaldehyde + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9650165", "l": "ASIC trimers bind H+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46858", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60721", "l": "(E)-hept-2-enal + H2O + NADP(+) => (E)-hept-2-enoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16391", "l": "CO2 + H2O + hydroquinone + NAD(+) => 4-hydroxybenzoate + 2 H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32258", "l": "meso-2,6-diaminoheptanedioate + NADP(+) <=> (S)-2,3,4,5-tetrahydrodipicolinate + 2 H(+) + NADPH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189406", "l": "4 PBGs bind to form HMB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39114", "l": "4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NADP(+) <=> 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56120", "l": "2-all-trans-heptaprenylphenol + H(+) + NADPH + O2 = 3-(all-trans-heptaprenyl)benzene-1,2-diol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46938", "l": "ATP + H(+) + L-2-aminoadipate + NADPH => (S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16026", "l": "an anthocyanidin 3-O-beta-D-glucoside + malonyl-CoA => an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097098", "l": "DNA/RNA hybrid annealing activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46229", "l": "apo-[peptidyl-carrier protein] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10170", "l": "biliverdin IXalpha + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => 15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66711", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> 2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61134", "l": "CO2 + H(+) + H2O + kaempferol + succinate => (2R,3R)-dihydrokaempferol + 2-oxoglutarate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38991", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35669", "l": "a 1,2-diacylglycerol + a fatty acid + H(+) => a triacylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15016", "l": "3alpha(S)-strictosidine + H2O <=> secologanin + tryptamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18742", "l": "10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA => 10-deacetylbaccatin III + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15136", "l": "H2O + L-glutamate + NAD(+) <=> 2-oxoglutarate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61117", "l": "(2R,3R)-dihydroquercetin + O2 + reduced [NADPH--hemoprotein reductase] => (2R,3R)-dihydromyricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698003", "l": "FLT3 mutants phosphorylate GAB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24222", "l": "(4R)-ipsdienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-myrcene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070186", "l": "growth hormone activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786034", "l": "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102663", "l": "gibberellin A34,2-oxoglutarate:oxygen oxidoreductase activity"}, {"i": "MetaCyc:RXN-292"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21429", "l": "(R)-3-sulfolactate => H(+) + pyruvate + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70482", "l": "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14555", "l": "2-oxoglutarate + cephalosporin C => (7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42245", "l": "H(+) + malonyl-[ACP] + propanoyl-CoA => 3-oxopentanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661625", "l": "FVIII is secreted (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191784", "l": "snRNA Cap hypermethylation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16938", "l": "1-O-alkyl-sn-glycerol + ATP => 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0051393", "l": "alpha-actinin binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004471", "l": "malate dehydrogenase (decarboxylating) (NAD+) activity"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0033735", "l": "aspartate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-984606", "l": "Kinesin-5 is a homotetramer (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102687", "l": "UDP-glucose:dihydrozeatin 7-N-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-4724"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51590", "l": "5-pyridoxolactone + H(+) + NADH => isopyridoxal + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912627", "l": "CBL ubiquitinates PI3K (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33676", "l": "H2O + N-(2,3-dihydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+) => H(+) + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50559", "l": "prostaglandin D2 <=> H2O + prostaglandin J2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55691", "l": "an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + H2O <=> 1D-myo-inositol 1-phosphate + an N-acyl-(4R)-4-hydroxysphinganine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42599", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 <=> prostaglandin G2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624948", "l": "KIF17 enters the cilium (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690873", "l": "ACO1 binds 4Fe-4S (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050491", "l": "sulcatone reductase activity"}, {"i": "RHEA:24484", "l": "NAD(+) + sulcatol = H(+) + NADH + sulcatone"}, {"i": "EC:1.1.1.260", "l": "\"Sulcatone reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174444", "l": "Formation of C-strand Okazaki fragments (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2990882", "l": "CDK1 phosphorylates NUP98 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39466", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA <=> (2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679044", "l": "FKBP1A binds sirolimus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45824", "l": "H(+) + L-serine = CO2 + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5229283", "l": "LCNs bind lipids (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57625", "l": "dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => 3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683925", "l": "ULK1 is dephosphorylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008404", "l": "arachidonic acid 14,15-epoxygenase activity"}, {"i": "RHEA:51472", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62815", "l": "4 monapinone A + O2 <=> 2 dinapinone A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114553", "l": "Activation of conventional Protein Kinase C (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37819", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34273", "l": "1,3-dihydro-2H-imidazol-2-one + H(+) + nitrite => 2-nitroimidazole + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56348", "l": "4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 = 2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+)"}, {"i": "RHEA:56368", "l": "3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 = 3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+)"}, {"i": "EC:1.14.19.55", "l": "\"4-hydroxybenzoate brominase (decarboxylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16684", "l": "4-hydroxyphenylacetate + H(+) + NADH + O2 <=> 3,4-dihydroxyphenylacetate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349626", "l": "Integrin alpha2beta1 binds laminin-332 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33314", "l": "2 A + hydroxylamine + NH4(+) <=> 2 AH2 + H(+) + H2O + N2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011543", "l": "DCA binds PDK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65874", "l": "17beta-hydroxyandrostan-1,3-dione + AH2 => 1,17beta-dihydroxyandrostan-3-one + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088162", "l": "FOXM1 binds CDC25A promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9641111", "l": "Parkin transfers Ub to misfolded proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39920", "l": "1-O-(alk-1-enyl)-sn-glycero-3-phosphate + H2O => 1-O-(alk-1-enyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10257", "l": "[(1->4)-6-phospho-alpha-D-glucosyl](n) + n ATP + n H2O => [(1->4)-3,6-bisphospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782234", "l": "Recovery of RNA synthesis after TC-NER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19819", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46487", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964759", "l": "Alternative endo-mannosidase I route (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375131", "l": "Basigin binds CD98 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41860", "l": "(3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39252", "l": "(2E,11Z)-eicosadienoyl-CoA + H(+) + NADPH => (11Z)-eicosenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975097", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004024", "l": "alcohol dehydrogenase activity, zinc-dependent"}, {"i": "REACT:R-HSA-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42273", "l": "3-methylbutanoyl-CoA + H(+) + malonyl-[ACP] => 5-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63024", "l": "(13Z)-docosenamide + H2O = (13Z)-docosenoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56077", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534096", "l": "METAP1/2 demethylates GNAT1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2545253", "l": "Deacetylation of cohesin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53796", "l": "deoxycholoyl-CoA + ursodeoxycholate = deoxycholate + ursodeoxycholoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868230", "l": "SNX9 recruits components of the actin polymerizing machinery (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917700", "l": "MVB Vesicle Formation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.44", "l": "\"[Acetyl-CoA carboxylase]-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034866", "l": "2,4,4-trimethylpentanoyl-CoA dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429732", "l": "multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0120016", "l": "sphingolipid transfer activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981621", "l": "Neuroglobin:oxygen dissociates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56823", "l": "AH2 + cyclooctat-9-en-7-ol + O2 <=> A + cyclooctat-9-ene-5,7-diol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41084", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28792", "l": "5,6-dihydrothymine + NAD(+) => H(+) + NADH + thymine"}]}
{"type": "biolink:MolecularActivity", "ic": "78.047734625335977", "identifiers": [{"i": "GO:0005496", "l": "steroid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668365", "l": "FVIIIa variant:FIXa does not convert FX to the active FXa (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35351", "l": "NADP(+) + octadecanoyl-CoA = (2E)-octadecenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15052", "l": "GDP-alpha-D-glucose + H2O <=> D-glucose + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-507868", "l": "Aquaporins passively transport water into cells (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205231", "l": "Dimerization of KIT upon SCF binding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11122", "l": "2 CO2 + NH4(+) => cyanate + 3 H(+) + hydrogencarbonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163489", "l": "phosphorylated HSL + H2O -> HSL + orthophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48241", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1b => CMP + ganglioside GT1b + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2473594", "l": "Collagen type II degradation by MMP15 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351948", "l": "Mitochondrial recruitment of Drp1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64338", "l": "4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one + 2 CO2 + 3 CoA => H(+) + 2 malonyl-CoA + nicotinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55290", "l": "CoA + tetradecanyl tetradecanoate => tetradecan-1-ol + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021523", "l": "WWP2 ubiquitinates NOTCH3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696465", "l": "USP45 deubiquitinates ERCC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41821", "l": "butanoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4411402", "l": "Activation of NLK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62601", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => 5-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31073", "l": "(S)-3-amino-2-methylpropanoate + pyruvate => (S)-methylmalonate semialdehyde + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983421", "l": "Journey of cargo through Golgi complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57080", "l": "glutathione + S-methyl-1-thio-D-xylulose 5-phosphate = 1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33110", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-muurolene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52036", "l": "H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate = L-isoleucine + tuberonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110156", "l": "UNG glycosylase mediated recognition and binding of an uracil opposite to a guanine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44307", "l": "a 1-acyl-sn-glycero-3-phosphate + dodecanoyl-CoA <=> a 1-acyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44404", "l": "3-demethylubiquinol-7 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-7"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033430", "l": "CGC codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8876446", "l": "p-ULK1 phosphorylates DENND3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18778", "l": "an alkylmercury + H(+) => an alkane + Hg(2+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-162657", "l": "Inactivation of Myt1 kinase (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865276", "l": "PDGF-AB clevage by Furin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730843", "l": "Phosphorylation of LAT by p-SYK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42592", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10000", "l": "H2O + pentanamide = NH4(+) + pentanoate"}, {"i": "EC:3.5.1.50", "l": "\"Pentanamidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003999", "l": "adenine phosphoribosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4755479", "l": "SUMOylation of NFKB2 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408555", "l": "Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50079", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25708", "l": "(E)-5-(methylsulfanyl)pentanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-dihomomethionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12965", "l": "ATP + D-galacturonate = 1-phospho-alpha-D-galacturonate + ADP + H(+)"}, {"i": "EC:2.7.1.44", "l": "\"Galacturonokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.71"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59970", "l": "CoA + O-octanoyl-L-threonyl-[protein] => L-threonyl-[protein] + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9650165", "l": "ASIC trimers bind H+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28208", "l": "ADP + dUMP + H(+) => 2'-deoxyuridine + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849882", "l": "SALMs 1-4 bind reticulon 3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209134", "l": "Phosphorylation of ARM by CKIalpha (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29696", "l": "cob(I)inamide(in) => cob(I)inamide(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48913", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1a => CMP + ganglioside GT1a + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30334", "l": "all-trans-beta-carotene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-zeaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40391", "l": "1-O-alkyl-2-acyl-sn-glycerol + an acyl-CoA = 1-O-alkyl-2,3-diacyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213201", "l": "Formation of collagen fibres (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5252001", "l": "ATP1B4 binds SNW1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62825", "l": "beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + GDP-beta-L-fucose => beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosamine + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008456", "l": "CDKN1A gene expression is inhibited by RUNX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12670", "l": "H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] => L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53921", "l": "ATP + L-threonyl-[Fas-activated protein] => ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30959", "l": "9,9'-di-cis-zeta-carotene + a quinone = 7,9,9'-tri-cis-neurosporene + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38961", "l": "a (2E)-enoyl-CoA + H2O2 => a 2,3-saturated acyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097678", "l": "SOCS family protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19809", "l": "(S)-ureidoglycolate + 2 H(+) + H2O = CO2 + glyoxylate + 2 NH4(+)"}, {"i": "EC:3.5.1.116", "l": "\"Ureidoglycolate amidohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37709", "l": "1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424254", "l": "LDLR transports extracellular CR:atREs to cytosol  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42277", "l": "2-methylbutanoyl-CoA + H(+) + malonyl-[ACP] => 4-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396029", "l": "Latent TGF-beta-3 binds integrins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44073", "l": "1-O-alkyl-2-acyl-sn-glycerol + ATP => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33201", "l": "butanal + H(+) + NADH => butan-1-ol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349455", "l": "Phosphorylation of MDM4 by ATM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201443", "l": "Type II receptor phosphorylates type I receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102702", "l": "2-carene synthase activity"}, {"i": "MetaCyc:RXN-5122"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27811", "l": "dimethylallyl diphosphate + 2 isopentenyl diphosphate => (2Z,6Z)-farnesyl diphosphate + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848930", "l": "PTK6 translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19783", "l": "3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate => 2-oxoglutarate + 3,5-diiodo-L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21315", "l": "2,5-dihydroxybenzoate + H(+) <=> CO2 + hydroquinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102185", "l": "4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol-4alpha-methyl oxidase activity"}, {"i": "MetaCyc:RXN-11947"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169468", "l": "MCM2-7 mediated fork unwinding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202703", "l": "CD47 binds SIRP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622737", "l": "FOXO3,FOXO6,(FOXO1) binds CAT gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5140741", "l": "WNT5A binds FZD and ROR receptors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34208", "l": "3-O-alpha-D-glucosyl-L-rhamnose + phosphate => beta-D-glucose 1-phosphate + L-rhamnopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029273", "l": "PI3K binds to p-6Y-SYK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161791", "l": "15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20299", "l": "a carboxylate + aniline + H(+) => an anilide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32378", "l": "limonene-1,2-diol + NAD(+) <=> 1-hydroxylimonen-2-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41438", "l": "cholesteryl (9Z-octadecenoate) + CoA => (9Z)-octadecenoyl-CoA + cholesterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54873", "l": "(1S,4R)-menthone + H(+) + NADPH + O2 => (4S,7R)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031963", "l": "cortisol receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665809", "l": "F8 variant does not bind von Willebrand factor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55818", "l": "5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide d + H(+) + L-methionine => a bacteriochlorophyllide d + H2O + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39005", "l": "a 1-acyl-sn-glycero-3-phosphate + ethanolamine + H(+) => a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3785768", "l": "MRN complex binds DNA double strand breaks (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20855", "l": "ATP + H(+)(in) + H2O <=> ADP + 2 H(+)(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8858252", "l": "HDLBP binds HDL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351948", "l": "Mitochondrial recruitment of Drp1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351936", "l": "Caspase-mediated cleavage of claspin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26044", "l": "acetyl-CoA + N-acetylneuraminate => CoA + N-acetyl-9-O-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28443", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + dodecanoyl-[ACP] => dodecanoyl-(Kdo)2-lipid IVA + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53581", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23891", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine <=> [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24812", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate <=> 3-methyl-2-oxobutanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37302", "l": "H2O + L-alanyl-L-threonine <=> L-alanine + L-threonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5626549", "l": "IQGAPs bind CALM1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32354", "l": "3 S-adenosyl-L-methionine + tricetin <=> 3',4',5'-O-trimethyltricetin + 3 H(+) + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13518", "l": "ATP + dTMP => ADP + dTDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29274", "l": "a menaquinol + H(+) + trimethylamine N-oxide <=> a menaquinone + H2O + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.80", "l": "\"Long-chain acyl-[acyl-carrier-protein] reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14889", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate = (5Z,7E,9E,14Z,17Z)-icosapentaenoate"}, {"i": "EC:5.3.3.13", "l": "\"Polyenoic fatty acid isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57628", "l": "3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate = H2O + ML-236C carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22897", "l": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH => a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35349", "l": "(2E)-octadecenoyl-CoA + H2O => 3-hydroxyoctadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29445", "l": "H(+)(out) + L-alanine(out) => H(+)(in) + L-alanine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32576", "l": "(2E)-geranyl diphosphate => (1R,5R)-alpha-pinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18491", "l": "carbamate + CO2 => cyanate + H(+) + hydrogencarbonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380311", "l": "Recruitment of Plk1 to centrosomes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54370", "l": "acetoin + CO2 => acetaldehyde + H(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047712", "l": "Cypridina-luciferin 2-monooxygenase activity"}, {"i": "RHEA:22760", "l": "Cypridina luciferin + O2 = CO2 + hnu + oxidized Cypridina luciferin"}, {"i": "EC:1.13.12.6", "l": "\"Cypridina-luciferin 2-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8866277", "l": "AP-2 directly binds some endocytic cargo (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601919", "l": "Unknown nuclease cleaves cleaved transposon RNA bound in MeR-PIWIL4:cleaved transposon RNA:TDRD9:MAEL:TDRKH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038054", "l": "G protein-coupled estrogen receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47655", "l": "D-ribitol 1-phosphate + H2O <=> phosphate + ribitol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31611", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene = H2O + rhodopin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54828", "l": "dimethylamine + H(+) + NADPH + O2 = formaldehyde + H2O + methylamine + NADP(+)"}, {"i": "EC:1.14.13.238", "l": "\"Dimethylamine monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202241", "l": "Recruitment of SLP-76 to Gads (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51564", "l": "cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = (25S)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.15.29", "l": "\"Cholest-4-en-3-one 26-monooxygenase ((25S)-3-oxocholest-4-en-26-oate forming)\""}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0052636", "l": "arabinosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71303", "l": "RPE dimers isomerise RU5P to XY5P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0051540", "l": "metal cluster binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786034", "l": "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40371", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ATP = 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ADP + H(+)"}, {"i": "EC:2.7.1.181", "l": "\"Polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40425", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61756", "l": "stevioside + UDP-alpha-D-glucose = H(+) + rebaudioside A + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31734", "l": "3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 <=> 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21979", "l": "[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite <=> [thioredoxin]-dithiol + adenosine 5'-phosphosulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373746", "l": "SEMA4D interacts with CD45 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55009", "l": "(1R,4S)-1-hydroxylimonen-2-one + NADPH + O2 => (3S)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22019", "l": "[glutaredoxin]-dithiol + arsenate + glutathione + 2 H(+) <=> arsenite + glutathionyl-S-S-[glutaredoxin] + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0003906", "l": "DNA-(apurinic or apyrimidinic site) endonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850831", "l": "KLK5 cleaves and activates KLK8 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33544", "l": "ergosteryl palmitate + H2O => ergosterol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17628", "l": "D-lysopine + H2O + NADP(+) <=> H(+) + L-lysine + NADPH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430311", "l": "Rsu-1 interacts with Pinch1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805546", "l": "Keratin type I binds keratin type II (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648888", "l": "p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874718", "l": "TTPA binds alpha-TOH (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2172678", "l": "PHF8 demethylates histone H4K20me1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39392", "l": "(2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH => (17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15131", "l": "(1S,6R)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59841", "l": "(6S)-5,6,7,8-tetrahydrofolate + syringate => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-O-methylgallate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65448", "l": "butanoyl-CoA + ethanol = CoA + ethyl butanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46329", "l": "L-threo-3-phenylserine => 3-phenylpyruvate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57278", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA => a 2'-deoxyguanosine in DNA + glyoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51995", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] <=> an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791144", "l": "Expression of EXTL3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798489", "l": "S100A7 or S100A7A binds Zn2+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174058", "l": "Degradation of multiubiquitinated Cdh1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005213", "l": "structural constituent of egg chorion"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015464", "l": "acetylcholine receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990599", "l": "3' overhang single-stranded DNA endodeoxyribonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50134", "l": "ethanol + H(+) + hexadecanoate => ethyl hexadecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446364", "l": "Migfilin interacts with VASP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051724", "l": "NAD transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139920", "l": "Translocation of tBID to mitochondria (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334099", "l": "UHRF1 binds chromatin with hemimethylated cytosine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1254251", "l": "ERBB4s80 binds YAP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6794347", "l": "Homer1,2,3 dimerizes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684836", "l": "CLEC1B dimer binds PDPN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685605", "l": "SLAMF7 binds SLAMF7 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13968", "l": "H2O + L,L-cystathionine <=> L-homocysteine + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51062", "l": "AH2 + androsta-1,4-diene-3,17-dione => 5alpha-androst-1-ene-3,17-dione + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62986", "l": "hexadecanoate + NH4(+) => H2O + hexadecanamide"}]}
{"type": "biolink:MolecularActivity", "ic": "79.238648346243679", "identifiers": [{"i": "GO:0004601", "l": "peroxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878117", "l": "RUNX3 binds ZFHX3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29575", "l": "L-serine(in) + Na(+)(in) = L-serine(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35409", "l": "4'-methoxyisoflavan-2',4,7-triol => H2O + medicarpin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3780997", "l": "PPP1R3C binds to glycogen:GYG2:GYS2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46957", "l": "hydrocaffeoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (E)-caffeoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49339", "l": "2,2-dihydroxyspheroidene <=> H2O + spheroiden-2-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64971", "l": "dUTP + H2O <=> dUDP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59493", "l": "(2E)-geranyl diphosphate + L-tryptophyl-[protein] => (2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9015111", "l": "Factor Xa inhibitors binds Xa (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199203", "l": "PANK1/3/4 phosphorylate PanK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60698", "l": "(R)-lavandulol + diphosphate => (R)-lavandulyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55803", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + N-acyleicosasphinganine + O2 <=> 2 [Fe(III)-cytochrome b5] + 2 H2O + N-acyleicosasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086223", "l": "Collagen type IX binds integrin alpha11beta1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30697", "l": "beta-alanine + 2 H(+) + NADH => 3-aminopropanal + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51674", "l": "glycolate + H(+) => glyoxal + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46051", "l": "D-galactosamine 6-phosphate <=> alpha-D-galactosamine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418863", "l": "Shp2 binds pUnc5C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27503", "l": "3',4',5'-O-trimethyltricetin + H(+) + S-adenosyl-L-homocysteine => 3',5'-di-O-methyltricetin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-990489", "l": "Kinesin-13 is a dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209815", "l": "Tyrosine is monoiodinated (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33525", "l": "acetate + ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) => ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604731", "l": "Autocatalytic activation of MMP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62523", "l": "a cytidine in rRNA + S-adenosyl-L-methionine <=> an N(4)-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031151", "l": "histone methyltransferase activity (H3-K79 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19441", "l": "benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030570", "l": "pectate lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156678", "l": "Activation of Cdc25C (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071972", "l": "peptidoglycan L,D-transpeptidase activity"}, {"i": "MetaCyc:RXN-11349"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044715", "l": "8-oxo-dGDP phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34078", "l": "an acyl phosphate + sn-glycerol 3-phosphate <=> a 1-acyl-sn-glycero-3-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.7.4", "l": "\"4-hydroxy-3-methylbut-2-enyl diphosphate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24625", "l": "ATP + L-threonine + tRNA(Thr) => AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210285", "l": "Trans-homophilic interaction of PECAM-1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420243", "l": "GHRH receptor binds GHRH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-164834", "l": "Enzyme-bound ATP is released (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15005", "l": "2-oxoglutarate + gibberellin A1 + O2 = CO2 + gibberellin A8 + succinate"}, {"i": "EC:1.14.11.13", "l": "\"Gibberellin 2-beta-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-500708", "l": "GRIK3 homomer binds glutamate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004157", "l": "dihydropyrimidinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50224", "l": "3-(all-trans-hexaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15473", "l": "flavanone 7-O-beta-D-glucoside + UDP-beta-L-rhamnose = flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] + H(+) + UDP"}, {"i": "EC:2.4.1.236", "l": "\"Flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49056", "l": "asperlicin C + H(+) + NADPH + O2 = asperlicin E + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33292", "l": "L-pentahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-8-(methylsulfanyl)octanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19061", "l": "H2O + NADP(+) + nitrite = H(+) + NADPH + nitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24120", "l": "H(+) + leukotriene E4 + NADPH + O2 = 20-hydroxy-leukotriene E4 + H2O + NADP(+)"}, {"i": "EC:1.14.13.34", "l": "\"Leukotriene-E(4) 20-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70971", "l": "citrate <=> isocitrate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34143", "l": "cannabinerolate + O2 = Delta(9)-tetrahydrocannabinolate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050580", "l": "2,5-didehydrogluconate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111870", "l": "Activation of PLC beta-1/4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797810", "l": "PTPRD binds IL1RAPL1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209960", "l": "Diiodinated tyrosine can be deiodinated (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5432849", "l": "S100A8:S100A9 binds TLR4:LY96 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52928", "l": "cyclic di-3',5'-guanylate + 2 H2O = 2 GMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11466", "l": "glutathione disulfide + 2 L-homocysteine => 2 glutathione + L,L-homocystine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54027", "l": "2-oxoglutarate + L-histidyl-[ribosomal protein uL15] + O2 <=> (3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647632", "l": "CASP3 cleaves GSDME (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19865", "l": "4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III"}, {"i": "EC:4.1.1.37", "l": "\"Uroporphyrinogen decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31008", "l": "(S)-2,3-epoxysqualene => beta-amyrin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63707", "l": "mycophenolate + UDP-alpha-D-glucuronate <=> H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41923", "l": "3-oxooctadecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10959", "l": "(E)-cinnamate + H(+) + NADPH + O2 <=> H2O + NADP(+) + trans-2-coumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8980691", "l": "RHOA GEFs activate RHOA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61486", "l": "a 5-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64685", "l": "L-threonyl-[protein] + UDP-alpha-D-glucose => 3-O-(alpha-D-glucosyl)-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388605", "l": "POMC(138-176) binds MC2R (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0062179", "l": "vitamin D 23-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008467", "l": "[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25955", "l": "1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde <=> 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769394", "l": "AKT phosphorylates CBY1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429036", "l": "SLC2A9 transports Fru, Glc, urate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209840", "l": "Two DITs combine to form thyroxine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029983", "l": "Dimerization of FGFR2 ligand-independent mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4332359", "l": "Active calmodulin binds CAMK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54253", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22619", "l": "2 H(+) + O2 + 2 sulochrin <=> 2 (2R)-bisdechlorogeodin + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40043", "l": "ATP + citrate + L-glutamate = ADP + beta-citrylglutamate + H(+) + phosphate"}, {"i": "EC:6.3.1.17", "l": "\"Beta-citrylglutamate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37541", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33515", "l": "2 5,6-dihydroxyindole + O2 = 2 H2O + 2 indole-5,6-quinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878056", "l": "RUNX1:CBFB binds EP300 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58248", "l": "5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = ADP-D-ribose + H(+) + L-glutamyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28440", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP] => dodecanoyl-(Kdo)2-lipid IVA + tetradecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209973", "l": "Tyrosine is diiodinated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64381", "l": "3 A + phytyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + 3 AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62094", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11456", "l": "N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}, {"i": "EC:2.4.1.101", "l": "\"Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.97", "l": "\"Endo-alpha-N-acetylgalactosaminidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29811", "l": "ATP + H2O + thiamine(out) = ADP + H(+) + phosphate + thiamine(in)"}, {"i": "EC:7.6.2.15", "l": "\"ABC-type thiamine transporter\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042557", "l": "eukaryotic elongation factor-2 kinase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629372", "l": "NEIL3 recognizes and binds to thymine glycol in telomeric DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687095", "l": "p-S215 FOXO3 binds MIR34B and C gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40337", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687079", "l": "IGF2BP1 binds MAPK4 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53791", "l": "allodeoxycholoyl-CoA + beta-muricholate <=> allodeoxycholate + beta-muricholoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102848", "l": "1-18:2-2-18:2-digalactosyldiacylglycerol desaturase activity"}, {"i": "MetaCyc:RXN-8310"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875183", "l": "CBL monoubiquitinates activated MET (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-888577", "l": "Synthesis of GABA by GAD2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35117", "l": "(4-coumaroyl)acetyl-CoA + CO2 + CoA => 4-coumaroyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32618", "l": "(6E)-8-oxogeraniol + NADP(+) <=> (6E)-8-oxogeranial + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-378975", "l": "Follitropin is a heterodimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49212", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,25-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047278", "l": "bilirubin-glucuronoside glucuronosyltransferase activity"}, {"i": "KEGG.REACTION:R00062"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357429", "l": "AXL autophosphorylates on Y772 and Y814 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.148", "l": "\"Lycopaoctaene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18940", "l": "an N-acyl-L-homoserine lactone + H2O <=> a carboxylate + L-homoserine lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62843", "l": "GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373747", "l": "Phosphorylation of nephrin by FYN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050660", "l": "flavin adenine dinucleotide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247836", "l": "Retromer recycles WLS to the Golgi (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44729", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165680", "l": "Formation of active mTORC1 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390929", "l": "HTR1 and 5A receptors can bind serotonin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19915", "l": "a 3-oxoacyl-[ACP] + H(+) + NADH => a (3R)-hydroxyacyl-[ACP] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814764", "l": "Plasma membrane resorption (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24056", "l": "a myo-inositol phosphate + H2O = myo-inositol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352059", "l": "SLC6A15-mediated amino acid uptake (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109862", "l": "MAP2K2 phosphorylates MAPK1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450348", "l": "Activated human JNKs migrate to nucleoplasm (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13836", "l": "L-arginine + pyruvate <=> 5-guanidino-2-oxopentanoate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66708", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-984689", "l": "Kinesin-7 is a dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430311", "l": "Rsu-1 interacts with Pinch1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182988", "l": "Sprouty lures CBL away from EGFR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15267", "l": "H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate => 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111879", "l": "PIP2 hydrolysis (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17644", "l": "H(+) + L-arginine <=> agmatine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31688", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23603", "l": "2-oxoglutarate + L-2-aminohexanoate <=> 2-oxohexanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5681987", "l": "LC3 is cleaved by ATG4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661517", "l": "LUBAC comlex binds OTULIN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120230", "l": "recombinase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42256", "l": "H(+) + hexanoyl-CoA + malonyl-[ACP] = 3-oxooctanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.1.1", "l": "\"NAD(P)(+) transhydrogenase (Si-specific)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972962", "l": "POU5F1 (OCT4), SOX2, NANOG bind the TDGF1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10666", "l": "H(+) + NADH + perillyl aldehyde => NAD(+) + perillyl alcohol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46140", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 22R-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442760", "l": "Activation of RasGRF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38625", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46025", "l": "H2O2 + tetradecanoate => (3R)-hydroxytetradecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28257", "l": "(3Z)-hex-3-en-1-ol + acetyl-CoA <=> (3Z)-hex-3-en-1-yl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49485", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(in) + ATP + H2O => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047677", "l": "arachidonate 8(R)-lipoxygenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0035594", "l": "ganglioside binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40574", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2993802", "l": "HLCS biotinylates PC:Mn2+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48628", "l": "a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15746", "l": "[(2->1)-beta-D-fructosyl](n) + sucrose => [(2->1)-beta-D-fructosyl](n+1) + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40141", "l": "(9Z)-octadecenoate + CoA + H(+) => (9Z)-octadecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.1.22", "l": "\"4-hydroxyproline betaine 2-epimerase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140703", "l": "3',3'-cyclic GMP-AMP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429714", "l": "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034947", "l": "terephthalate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052822", "l": "DNA-3-methylguanine glycosylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40296", "l": "ATP + CoA + hexadecanedioate => AMP + diphosphate + hexadecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856189", "l": "TNFSF8 binds TNFRSF8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35135", "l": "L-alanyl-L-glutamate(out) = L-alanyl-L-glutamate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157145", "l": "NOTCH3 binds DLL1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865320", "l": "CBFB binds RUNX1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51681", "l": "(2E,6E)-farnesol + CTP => (2E,6E)-farnesyl phosphate + CDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928617", "l": "EPHB2 binds KALRN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23339", "l": "2 H(+) + H2O2 + 2 iodide <=> diiodine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693009", "l": "Expression of AMH in testis differentiation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44101", "l": "H2O + NAD(+) + octanal => 2 H(+) + NADH + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936985", "l": "Activated TLR4:TICAM1 recruits TRAF6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24558", "l": "5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH => 5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45007", "l": "(R)-carnitine + 2,6-dimethylheptanoyl-CoA <=> CoA + O-2,6-dimethylheptanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25615", "l": "terpentedienyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392202", "l": "Dissociation of the P2Y purinoceptor 12:Gi complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20580", "l": "3-hydroxyaminophenol <=> aminohydroquinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202307", "l": "Change of PKC theta conformation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030338", "l": "CMP-N-acetylneuraminate monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61186", "l": "H(+) + quercetin 3,7-bis-O-alpha-L-rhamnoside + UDP => quercitrin + UDP-beta-L-rhamnose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805061", "l": "CK2 binds FACT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57562", "l": "7-deoxyloganetate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => (+)-cis-trans-nepetalactol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54193", "l": "L-lysyl-[protein] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10212", "l": "2-oxoglutarate + 5-aminopentanoate = 5-oxopentanoate + L-glutamate"}, {"i": "EC:2.6.1.48", "l": "\"5-aminovalerate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18911", "l": "2,4,6-trichloroanisole + S-adenosyl-L-homocysteine => 2,4,6-trichlorophenol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32050", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate <=> adenosine 5'-pentaphosphate + AMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5252001", "l": "ATP1B4 binds SNW1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62255", "l": "2 hydrogencarbonate(out) + Zn(2+)(out) <=> 2 hydrogencarbonate(in) + Zn(2+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34859", "l": "3-oxocyclopentanecarbonitrile + 2 H2O = 3-oxocyclopentanecarboxylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.98.1.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37954", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> (10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663293", "l": "RORA, EP300 bind SREBF1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24634", "l": "5 H(+) + 3 NADPH + nitrite => 2 H2O + 3 NADP(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22332", "l": "(3R)-citramalate = 2-methylmaleate + H2O"}, {"i": "RHEA:42424", "l": "2-methylmaleate + H2O = (2R,3S)-3-methylmalate"}, {"i": "EC:4.2.1.35", "l": "\"(R)-2-methylmalate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13047", "l": "ent-kaur-16-en-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-ene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692749", "l": "CDC14A,B bind MAPK6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44371", "l": "Cr(6+) + 2 NADPH + O2 <=> Cr(3+) + 2 H(+) + 2 NADP(+) + superoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37786", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine <=> 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008389", "l": "coumarin 7-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62083", "l": "D-glucose 6-sulfate + NADP(+) <=> 6-sulfo-D-glucono-1,5-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33174", "l": "D-maltose(in) <=> D-maltose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6797090", "l": "CCNK binds CDK12 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26564", "l": "1,4-dihydroxy-2-naphthoyl-CoA + H2O => 2-succinylbenzoyl-CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803388", "l": "TP53 stimulates CDKN1A (p21) transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56557", "l": "(2E,6E)-farnesyl diphosphate => delta-cadinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649726", "l": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11463", "l": "ADP + D-glucose <=> AMP + D-glucose 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30551", "l": "acetyl-CoA + beta-D-glucose = 6-O-acetyl-beta-D-glucose + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27650", "l": "GTP + uridine = GDP + H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858252", "l": "HDLBP binds HDL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52262", "l": "a bacteriochlorophyllide e + H2O => a 7(1),7(1)-dihydroxybacteriochlorophyllide c"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29508", "l": "(2E,6E)-farnesyl diphosphate => (-)-alpha-gurjunene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2172126", "l": "DAP12 interacts with NKG2C (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63810", "l": "AMP + diphosphate + H(+) + N(8)-citryl-spermidine => ATP + citrate + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38837", "l": "1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198611", "l": "AKT phosphorylates IKKalpha (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001729", "l": "ceramide kinase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0036009", "l": "protein-glutamine N-methyltransferase activity"}, {"i": "REACT:R-HSA-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35005", "l": "L-fucose(out) => L-fucose(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730863", "l": "Phosphorylation of CARMA1 by PKC-theta (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36002", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019864", "l": "IgG binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373075", "l": "Metabotropic glutamate receptors bind glutamate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429732", "l": "multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354097", "l": "Activation of Talin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10790", "l": "6-phospho-2-dehydro-D-gluconate + ADP + H(+) => 2-dehydro-D-gluconate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.4", "l": "\"Glucose oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58269", "l": "[protein]-C-terminal glycine + NAD(+) => [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196929", "l": "FLAD1 phosphorylates FMN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64622", "l": "(E)-sinapoyl actetate + CoA => (E)-sinapoyl alcohol + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54885", "l": "L-arginyl-[protein] + NADP(+) => H(+) + N(omega)-(2'-phospho-ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626816", "l": "PIN1 binds p-S345-NCF1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41645", "l": "2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA => 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11921", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin => (6R)-L-erythro-6,7-dihydrobiopterin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20461", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + 3 S-adenosyl-L-methionine = an N,N,N-trimethylornithine lipid + 3 H(+) + 3 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.344", "l": "\"Ornithine lipid N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24964", "l": "calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcitetrol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12854", "l": "(S)-4-hydroxymandelonitrile + UDP-alpha-D-glucose => dhurrin + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19566", "l": "(2E)-geranyl diphosphate + H2O => diphosphate + sabinene hydrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15777", "l": "1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O = 1-guanidino-1-deoxy-scyllo-inositol + phosphate"}, {"i": "EC:3.1.3.40", "l": "\"Guanidinodeoxy-scyllo-inositol-4-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24990", "l": "calcitroate + H2O + 2 oxidized [adrenodoxin] => (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37400", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001055", "l": "RNA polymerase II activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60652", "l": "an N-(acyl)-sphingosylphosphocholine = an N-(acyl)-sphingosyl-1,3-cyclic phosphate + choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168878", "l": "PB1-F2 binds to the mitochondrial adenine nucleotide translocator 3 ANT3, inducing apoptosis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672973", "l": "MAP2Ks phosphorylate MAPKs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34662", "l": "C30 botryococcene + S-adenosyl-L-methionine <=> 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18176", "l": "(2R)-1-(4-hydroxyphenyl)-2-aminoethanol <=> (4-hydroxyphenyl)acetaldehyde + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58573", "l": "O-acetyl-15alpha-stemmadenine + O2 => H2O2 + precondylocarpine acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58167", "l": "(2E,6E)-farnesyl diphosphate + 2 H2O <=> 7-epi-ent-eudesmane-5,11-diol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49571", "l": "2-glutathionyl-2-methylbut-3-en-1-ol <=> (3R)-3,4-epoxy-3-methylbut-1-ene + glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033853", "l": "aspartate-prephenate aminotransferase activity"}, {"i": "MetaCyc:PREPHENATE-ASP-TRANSAMINE-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002171", "l": "low-affinity IgA receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709547", "l": "ESTG binds ESR2:chaperone complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205244", "l": "Recruitment of CBL to KIT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65261", "l": "verruculide C epoxide => 3-hydroxypentacecilide A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928607", "l": "p-EPHs bind VAV2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16792", "l": "a (2S)-2-hydroxycarboxylate + O2 <=> a 2-oxocarboxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-481010", "l": "Surface deployment of platelet dense granule membrane components (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634228", "l": "TRAF1 is cleaved by caspases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022878", "l": "protein-N(PI)-phosphohistidine-sucrose phosphotransferase system transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013108", "l": "GDIs block activation of RHOC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183126", "l": "Factor B binds to surface-associated C3b (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47409", "l": "(24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O => (24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045436", "l": "lycopene beta cyclase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043778", "l": "cobalt-precorrin-8 methylmutase activity"}, {"i": "MetaCyc:RXN-8768"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66555", "l": "L-glutaminyl-[protein] + serotonin <=> 5-serotonyl-L-glutamyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008849", "l": "enterochelin esterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39605", "l": "(2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H2O => (3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66885", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 11-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9649733", "l": "mature p21 RAS binds GDP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852200", "l": "Inactivation of LCK by PTPN22 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940554", "l": "MMP2 cleaves OPTC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61351", "l": "ATP + estrone 3-sulfate(in) + H2O <=> ADP + estrone 3-sulfate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55905", "l": "7-chloro-L-tryptophan + chloride + FADH2 + O2 => 6,7-dichloro-L-tryptophan + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38169", "l": "CoA + hexadecanyl hexadecanoate => hexadecan-1-ol + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110319", "l": "Elongation by POLH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13066", "l": "ATP + H2O => ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166544", "l": "TrkA receptor autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52964", "l": "hyodeoxycholate + UDP-alpha-D-glucuronate = H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35768", "l": "dihydrosterigmatocystin + S-adenosyl-L-methionine => 8-O-methyldihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10237", "l": "trans-2-coumarate + UDP-alpha-D-glucose => H(+) + trans-beta-D-glucosyl-2-hydroxycinnamate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58720", "l": "(S)-nicotine + NADPH + O2 = H2O + NADP(+) + trans-(S)-nicotine N(1')-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952371", "l": "MDM2 binds RUNX3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102130", "l": "malonyl-CoA methyltransferase activity"}, {"i": "RHEA:17105", "l": "malonyl-[ACP] + S-adenosyl-L-methionine = malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.197", "l": "\"Malonyl-[acyl-carrier protein] O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140581", "l": "P-type monovalent copper transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624272", "l": "MMPs cleave HB-EGF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800315", "l": "MST1 binds MST1R (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534388", "l": "Progesterone Activation Of CatSper (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11976", "l": "anhydrotetracycline + H(+) + NADPH + O2 = 5a,11a-dehydrotetracycline + H2O + NADP(+)"}, {"i": "EC:1.14.13.38", "l": "\"Anhydrotetracycline 6-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199203", "l": "PANK1/3/4 phosphorylate PanK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30101", "l": "2-demethylmenaquinol-8 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011983", "l": "Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004222", "l": "metalloendopeptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15205", "l": "a dolichyl diphosphooligosaccharide + H2O = an oligosaccharide-(1->4)-N-acetyl-beta-D-glucosamine-(1->4)-N-acetyl-alpha-D-glucosamine 1-phosphate + dolichyl phosphate + 2 H(+)"}, {"i": "EC:3.6.1.44", "l": "\"Oligosaccharide-diphosphodolichol diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29747", "l": "3-phenylpropanoate(in) = 3-phenylpropanoate(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034934", "l": "phenanthrene-4-carboxylate dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22191", "l": "an (R)-2-haloacid + H2O <=> a (2S)-2-hydroxycarboxylate + a halide anion + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61720", "l": "a D-guloside + NAD(+) = a 3-dehydro-D-guloside + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59705", "l": "D-cellohexaono-1,5-lactone + H2O => D-cellohexaonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30005", "l": "alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP => alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18818", "l": "acetyl-CoA + malonate => acetate + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10126", "l": "benzyl acetate + H2O + NADP(+) => H(+) + NADPH + O2 + phenylacetone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45362", "l": "(11Z)-eicosenoate + sphinganine => H2O + N-(11Z-eicosenoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49034", "l": "4'-demethylepipodophyllotoxin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-4'-desmethyl-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20964", "l": "2-oxoglutarate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636251", "l": "PPE2 binds KPNA1:KPNB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197963", "l": "DHFR2 reduces FOLA to DHF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061849", "l": "telomeric G-quadruplex DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23556", "l": "D-alanine + L-glutamine = gamma-L-glutamyl-D-alanine + NH4(+)"}, {"i": "EC:2.3.2.14", "l": "\"D-alanine gamma-glutamyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875183", "l": "CBL monoubiquitinates activated MET (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26339", "l": "H(+) + 2 L-methionine => L-homocysteine + S-methyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31764", "l": "a 2-oxocarboxylate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871227", "l": "RET binds GFRA4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58435", "l": "(E)-4-oxonon-2-en-1-ol + NADP(+) <=> (E)-4-oxonon-2-enal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168400", "l": "iE-DAP elicits a NOD1 response (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66480", "l": "gypsogenin + UDP-alpha-D-glucose = gypsogenin 28-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350901", "l": "Iodide is organified (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53474", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z)-octadecadienoate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + cholesterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018519", "l": "cis-dihydroethylcatechol dehydrogenase activity"}, {"i": "MetaCyc:1.3.1.66-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16101", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate = n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+)"}, {"i": "EC:2.8.2.5", "l": "\"Chondroitin 4-sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031891", "l": "type 1 vasoactive intestinal polypeptide receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60024", "l": "(R,R)-chrysanthemyl diphosphate + H2O = (R,R)-chrysanthemol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22252", "l": "globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = globoside Gb4Cer (d18:1(4E)) + H(+) + UDP"}, {"i": "EC:2.4.1.79", "l": "\"Globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420083", "l": "PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61894", "l": "a 4,5-saturated-(3E)-enoyl-CoA + NADP(+) => a (2E,4Z)-dienoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2995334", "l": "COX15 transforms heme O to heme A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786110", "l": "JAK1 binds IL4R in IL13-bound IL13R type II (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099085", "l": "DIF dechlorinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17939", "l": "methylglyoxal + phosphate => dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66152", "l": "acetyl-CoA + noradrenaline = CoA + H(+) + N-acetylnoradrenaline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13268", "l": "1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine <=> 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28258", "l": "cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate = cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP"}, {"i": "EC:2.4.1.254", "l": "\"Cyanidin-3-O-glucoside 2''-O-glucuronosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16113", "l": "2 cob(II)alamin--[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+) = 2 apo--[cyanocobalamin reductase] + 2 cyanocob(III)alamin + H(+) + NADPH"}, {"i": "EC:1.16.1.6", "l": "\"Cyanocobalamin reductase (cyanide-eliminating)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018472", "l": "1-hydroxy-2-naphthaldehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60219", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662986", "l": "MT2A binds copper (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34049", "l": "6'''-deamino-6'''-oxoneomycin C + H2O2 => 6'''-deamino-6'''-hydroxyneomycin C + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61826", "l": "H(+) + pregnenolone 3-beta-D-glucoside + UDP => pregnenolone + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11349", "l": "arsenite(in) + ATP + H2O => ADP + arsenite(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36550", "l": "octadecanoyl-CoA + sphinganine <=> CoA + H(+) + N-(octadecanoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15458", "l": "cis-1,2-dihydrobenzene-1,2-diol + NAD(+) => catechol + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28916", "l": "4-aminobutanoate(in) + H(+)(in) => 4-aminobutanoate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1471322", "l": "Beta-defensins are secreted (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236970", "l": "Proteasomal clevage of exogenous antigen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17107", "l": "malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine => malonyl-[ACP] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015231", "l": "5-formyltetrahydrofolate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174097", "l": "Association of Emi1 with Cdh1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006870", "l": "IL21 receptor STAT phosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982645", "l": "GRKs bind ADRB2:Catecholamine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51837", "l": "(9Z)-tetradecenoate(out) + ATP(in) + CoA(in) + H(+)(out) => (9Z)-tetradecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693319", "l": "CTRC hydrolyses PRSS1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050616", "l": "secologanin synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814088", "l": "SYS1 binds AcM-ARFRP1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22899", "l": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH <=> a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59690", "l": "D-maltoheptaono-1,5-lactone + H2O2 => D-maltoheptaose + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1011598", "l": "DOCKs bind to RhoGEFs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51103", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0045119", "l": "azole:proton antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871227", "l": "RET binds GFRA4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35106", "l": "fusidate(in) <=> fusidate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13118", "l": "O-acetyl-L-serine + pyrazole => 3-(pyrazol-1-yl)-L-alanine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14083", "l": "D-glyceraldehyde 3-phosphate + indole => (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21439", "l": "[translation elongation factor 2] + ATP <=> [translation elongation factor 2]-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11508", "l": "2-oxoglutarate + L-aspartyl-[protein] + O2 = 3-hydroxy-L-aspartyl-[protein] + CO2 + succinate"}, {"i": "EC:1.14.11.16", "l": "\"Peptide-aspartate beta-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050261", "l": "ribose isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56326", "l": "(DNA)-(deoxyribonucleoside 5'-phosphate) + H(+) + S-methyl-L-cysteinyl-[protein] => (DNA)-(deoxyribonucleoside 5'-methylphosphotriester) + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193537", "l": "5beta-cholestan-3alpha, 7alpha-diol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65946", "l": "3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine => AH2 + CTP + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67029", "l": "(glutathione)4[2Fe(III)-2S] cluster(in) + ATP + H2O => (glutathione)4[2Fe(III)-2S] cluster(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36359", "l": "2 a plastoquinone + 2 H2O + 4 hnu = 2 a plastoquinol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26028", "l": "H2O + N(1)-acetylspermidine + O2 => 3-aminopropanal + H2O2 + N-acetylputrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624494", "l": "RAF1 binds p21 RAS:GTP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58488", "l": "4-(trimethylamino)butanoate + H(+) + NADH + O2 = H2O + NAD(+) + succinate semialdehyde + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47525", "l": "cholate + NAD(+) => 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905577", "l": "ganglioside GP1c binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446372", "l": "Association of  PARVA with TESK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45298", "l": "a sphingoid base + H(+) + phosphocholine => a sphingosylphosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47967", "l": "H2O + N(pros)-phospho-L-histidyl-[protein] <=> L-histidyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34983", "l": "sulfate(in) = sulfate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63112", "l": "A + ascofuranol = AH2 + ascofuranone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24275", "l": "H(+) + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2 <=> H2O + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005277", "l": "acetylcholine transmembrane transporter activity"}, {"i": "REACT:R-HSA-264615", "l": "Loading of acetylcholine in synaptic vesicles (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211219", "l": "Translocation of caspase-3 to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873921", "l": "Binding of STAT1 to p-IFNGR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15091", "l": "AH2 + pyruvate => (R)-lactate + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64543", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848087", "l": "STAP2 recruits STAT3 to PTK6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803719", "l": "TP53 binds ZNF385A (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9737780", "l": "MTTP binds lomitapide (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19047", "l": "(3R)-citramalate + CoA + H(+) => acetyl-CoA + H2O + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33885", "l": "3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADH => 2-deoxy-scyllo-inosamine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50376", "l": "a ceramide(in) + ATP + H2O = a ceramide(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16300", "l": "5alpha-androstane-3beta,17beta-diol + NADP(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32247", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) = (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51016", "l": "7,8-dihydroneopterin 3'-phosphate = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde phosphate"}, {"i": "EC:4.1.2.59", "l": "\"Dihydroneopterin phosphate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59993", "l": "H(+) + oxidized [electron-transfer flavoprotein] + phloretate => (E)-4-coumarate + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66070", "l": "H2O + kynurenate + L-leucine => 4-methyl-2-oxopentanoate + L-kynurenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050637", "l": "lovastatin nonaketide synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-168412", "l": "MDP elicits a NOD2 response (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0099107", "l": "ion channel regulator activity involved in G protein-coupled receptor signaling pathway"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9624798", "l": "LBR binds KPNB1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29000", "l": "H(+)(out) + homoserine lactone(in) => H(+)(in) + homoserine lactone(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47498", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADPH => lithocholate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63814", "l": "AMP + diphosphate + H(+) + N(8),N'(8)-citryl-bis(spermidine) => ATP + N(8)-citryl-spermidine + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58058", "l": "2-sulfinoacetaldehyde + L-alanine => hypotaurine + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57741", "l": "a 2,3-saturated meromycolyl-[ACP] + NAD(+) => a trans-Delta(2)-meromycolyl-[ACP] + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5213466", "l": "RIPK3 is phosphorylated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015422", "l": "ABC-type oligosaccharide transporter activity"}, {"i": "MetaCyc:3.6.3.18-RXN"}, {"i": "EC:7.5.2.2", "l": "\"ABC-type oligosaccharide transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47355", "l": "a hexanoate ester + H2O <=> an aliphatic alcohol + H(+) + hexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32984", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + 2 H2O => 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-1D-myo-inositol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097602", "l": "cullin family protein binding"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0001050", "l": "single-subunit type RNA polymerase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956649", "l": "The complex of RUNX1 and YAP1 binds the ITCH gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042978", "l": "ornithine decarboxylase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64210", "l": "a fatty acid + L-glutamine => an N-(fatty acyl)-L-glutamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51173", "l": "cytidine(62) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(62) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66617", "l": "Mg(2+)(in) + 2 Na(+)(out) => Mg(2+)(out) + 2 Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12522", "l": "(E)-caffeate + NH4(+) => L-dopa"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20226", "l": "(E)-caffeate + S-adenosyl-L-methionine => (E)-ferulate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17902", "l": "S-adenosyl-L-methionine + xanthotoxol => H(+) + S-adenosyl-L-homocysteine + xanthotoxin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046424", "l": "ferulate 5-hydroxylase activity"}, {"i": "MetaCyc:RXN-1121"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18717", "l": "3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine = 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.84", "l": "\"Methylquercetagetin 6-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46664", "l": "corticosterone + H(+) + NADPH = 5beta-dihydrocorticosterone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45098", "l": "(9Z,12Z)-hexadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (9Z)-hexadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25668", "l": "beta-pinene + diphosphate => (2E)-geranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395992", "l": "p-T,4S-IRF3 is dimerized (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351207", "l": "Spermine  => N-acetylated spermine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70613", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5444511", "l": "Formation of MSH2:MSH3 Complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57719", "l": "hydrogencarbonate + NH4(+) <=> carbamate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32270", "l": "4-aminobutanoate + glyoxylate <=> glycine + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018422", "l": "GDP-mannose:serine-protein mannose-1-phosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61070", "l": "19-O-acetylhorhammericine + CoA => acetyl-CoA + horhammericine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47126", "l": "H2O + N-hexacosanoylglycine => glycine + hexacosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62470", "l": "3,4-dihydroxybenzoyl-5'-AMP + diphosphate => 3,4-dihydroxybenzoate + ATP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50159", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 <=> N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.97"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2314678", "l": "Aspirin acetylates PTGS1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814096", "l": "ARL1:GTP binds SCOC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21528", "l": "[phosphate](n) + H2O = [phosphate](n-1) + H(+) + phosphate"}, {"i": "EC:3.6.1.11", "l": "\"Exopolyphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48056", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O = beta-D-glucosylceramide + D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24663", "l": "H(+) + L-arginine + NADPH + O2 <=> H2O + N(omega)-hydroxy-L-arginine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65688", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(38-hydroxyoctatriacontenoyl)-sphing-4-enine = a diacylglycerol + an N-(38-(9Z,12Z-octadecadienoyloxy)-octatriacontenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29177", "l": "2 H(+) + 2 superoxide + ubiquinone-8 => 2 O2 + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19646", "l": "a D-threo-aldose + NAD(+) => a D-threo-aldono-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30164", "l": "germacra-1(10),4,11(13)-trien-12-al + H2O + NADP(+) => germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854052", "l": "Formation of the SCF-FBXL7 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56980", "l": "4-hydroxybenzyl alcohol + 2 oxidized [azurin] = 4-hydroxybenzaldehyde + 2 H(+) + 2 reduced [azurin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381608", "l": "cAMP activates EPAC2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1591234", "l": "ZBP1 binds cytosolic DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174706", "l": "chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47665", "l": "H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) => 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852317", "l": "PLK1 phosphorylates GTSE1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18898", "l": "3,3',5'-triiodo-L-thyronine + A + H(+) + iodide => AH2 + L-thyroxine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64149", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-R + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43987", "l": "(2E,6E)-farnesol + H(+) + NADPH + O2 <=> (2E,6E)-omega-hydroxy-farnesol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655836", "l": "Expression of Diphosphomevalonate Decarboxylase (MVD) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58965", "l": "H2O + hexanal + O2 => H(+) + H2O2 + hexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672164", "l": "GRB2:SOS1 complex binds to mutant PDGFR receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50699", "l": "calciol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> calcidiol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60152", "l": "H2O + L-gamma-glutamyl-L-glutamyl-[protein] = L-glutamate + L-glutamyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645598", "l": "RRAGC,D hydrolyzes GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11403", "l": "GDP-6-deoxy-alpha-D-altrose + sordaricin <=> 4'-O-demethylsordarin + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12838", "l": "ATP + choline => ADP + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60689", "l": "(11R)-dihydroartemisinic aldehyde + H2O + NAD(+) => (11R)-dihydroartemisinate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35904", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65550", "l": "alpha-Fuc-(1->2)-beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-Glc + an N-acyl-sphingoid base => ganglioside Fuc-GM1 + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103088", "l": "2-(6'-methylthio)hexylmalate synthase activity"}, {"i": "MetaCyc:RXNQT-4172"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432507", "l": "Cytosolic TIM is degraded by the 26S proteasome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12447", "l": "hexadecanal + NADP(+) <=> (2E)-hexadecenal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046525", "l": "xylosylprotein 4-beta-galactosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50765", "l": "4-amino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine => 4-methylamino-4-dedimethylamino-anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445072", "l": "Interaction of PAK1 with Rac1-GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12639", "l": "(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP => (5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0048019", "l": "receptor antagonist activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140485", "l": "5-aminolevulinic acid transmembrane transporter activity"}, {"i": "RHEA:64816", "l": "5-aminolevulinate(in) = 5-aminolevulinate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19162", "l": "2 2-aminophenol + O2 => 2 6-iminocyclohexa-2,4-dienone + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627089", "l": "CASP9 is phosphorylated at T125 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56431", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21595", "l": "(2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD(+) <=> H(+) + L-2-aminopentanoate + NADH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685607", "l": "Sialic acid binds SIGLEC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54141", "l": "cytidine(49) in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine(49) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13595", "l": "CO2 + NH4(+) + ureidoglycine => allantoate + 2 H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70479", "l": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38255", "l": "(S)-malate + succinyl-CoA = (S)-malyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424482", "l": "p85 regulatory unit of PI3K binds p-6Y-SYK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48445", "l": "H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol => a fatty acid + H(+) + long chain 2-acyl-3-O-beta-D-galactosyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3315455", "l": "Defective CBLIF does not bind Cbl (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010298", "l": "dihydrocamalexic acid decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63921", "l": "octadecanoyl-CoA + sphinga-4E,14Z-dienine => CoA + H(+) + N-octadecanoyl-sphinga-4E,14Z-dienine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.160", "l": "\"Caffeine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25951", "l": "a 1,2-diacyl-sn-glycerol + CTP <=> a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14509", "l": "2-oxoglutarate + mugineate + O2 = 3-epihydroxymugineate + CO2 + H(+) + succinate"}, {"i": "RHEA:20065", "l": "2'-deoxymugineate + 2-oxoglutarate + O2 = 3-epihydroxy-2'-deoxymugineate + CO2 + H(+) + succinate"}, {"i": "EC:1.14.11.25", "l": "\"Mugineic-acid 3-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36351", "l": "AH2 + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + A + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434990", "l": "SEMA7A binds to integrin alpha1beta1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202731", "l": "JAM3 dimerises (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44756", "l": "2-methoxy-6-all-trans-heptaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53707", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O <=> H(+) + prostaglandin E2 + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11869", "l": "D-arabinitol + NADP(+) => D-ribulose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66451", "l": "(E)-pent-2-en-1-ol + NADP(+) <=> (E)-2-pentenal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28281", "l": "3-sulfino-L-alanine + H2O <=> H(+) + L-alanine + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686088", "l": "CASP3 cleaves GSDMD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-481007", "l": "Exocytosis of platelet alpha granule contents (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839065", "l": "Phosphorylation of cytosolic FGFR1 fusion dimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38106", "l": "L-galactonate <=> 2-dehydro-3-deoxy-L-galactonate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46494", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(out) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58039", "l": "8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) <=> 8-epi-inunolide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41413", "l": "1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O => 1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31337", "l": "diphosphate + Mo-molybdopterin cytosine dinucleotide => CTP + H(+) + Mo-molybdopterin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045302", "l": "choloylglycine hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17378", "l": "dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] => 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6813749", "l": "ALDH1A1 oxidises GA to DGA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948641", "l": "miR-106 microRNAs bind VAPA mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55565", "l": "4-hydroxytryptamine + ATP => 4-hydoxytryptamine 4-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37717", "l": "1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27657", "l": "2-oxobutanoate + H(+) + pyruvate <=> (S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27431", "l": "a 1,2-diacyl-sn-glycerol + phosphate => a 1,2-diacyl-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019178", "l": "NADP phosphatase activity"}, {"i": "MetaCyc:NADPPHOSPHAT-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113402", "l": "Formation of DSIF:NELF:early elongation complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56037", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809707", "l": "MTMR12 binds MTMR2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23763", "l": "H(+) + H2 + oxidized coenzyme F420-(gamma-Glu)(n) <=> reduced coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39675", "l": "(9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009702", "l": "L-arabinokinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66023", "l": "H2O2 + L-lysyl-[collagen] + L-methionyl-[collagen] <=> [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375140", "l": "CDO binds promyogenic cadherins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172126", "l": "DAP12 interacts with NKG2C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64268", "l": "emodin anthrone + O2 = emodin + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449978", "l": "IL7 binds IL7R:JAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050500", "l": "1,3-beta-galactosyl-N-acetylhexosamine phosphorylase activity"}, {"i": "MetaCyc:2.4.1.211-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19344", "l": "2 H(+) + O2 + octane + 2 reduced [rubredoxin] <=> H2O + octan-1-ol + 2 oxidized [rubredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38019", "l": "(9Z)-octadecenoyl-CoA + 1-decanoylglycerol = 1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193068", "l": "CYP17A1 17-hydroxylates PREG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9639286", "l": "RRAGC,D exchanges GTP for GDP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25495", "l": "(2E)-geranyl diphosphate <=> (-)-beta-phellandrene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62795", "l": "3 H(+) + NADPH + O2 + 2 rubrofusarin B <=> 2 H2O + NADP(+) + nigerone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683635", "l": "E pentamer is transported to the Golgi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18425", "l": "L-quinate + NADP(+) = 3-dehydroquinate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917987", "l": "TFRC dimer binds 2xholoTF (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372542", "l": "Loading of dopamine into synaptic veiscles (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13281", "l": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH"}, {"i": "EC:1.1.1.178", "l": "\"3-hydroxy-2-methylbutyryl-CoA dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700156", "l": "Active ALK dimer binds IRS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17630", "l": "alpha,alpha-trehalose(in) => alpha,alpha-trehalose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22641", "l": "NADP(+) + sphinganine => 3-oxosphinganine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15202", "l": "6-hydroxymellein + S-adenosyl-L-methionine => 6-methoxymellein + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28069", "l": "CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) <=> alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2534365", "l": "Slo3 Potassium Transport (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21698", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8869683", "l": "oxPL binds LBP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56656", "l": "12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+) = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H(+) + NADH"}, {"i": "EC:1.3.1.114", "l": "\"3-dehydro-bile acid Delta(4,6)-reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27793", "l": "2-all-trans-octaprenylphenol + H(+) + NADPH + O2 <=> 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173680", "l": "Activation of C5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.2.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61133", "l": "(2R,3R)-dihydrokaempferol + 2-oxoglutarate + O2 => CO2 + H(+) + H2O + kaempferol + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62001", "l": "3 A + protoporphyrinogen IX => 3 AH2 + protoporphyrin IX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62706", "l": "2,3-didehydrophenylalanine + glycine => glycyldehydrophenylalanine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38349", "l": "2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate => (S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809309", "l": "MTMR6 binds MTMR9 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679819", "l": "TBK1 binds amlexanox (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30135", "l": "dodecanoyl-CoA + H2O = CoA + dodecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14577", "l": "(R)-carnitine = crotonobetaine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13927", "l": "holo-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine => (3R)-hydroxytetradecanoyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696268", "l": "RND3 binds effectors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43434", "l": "2 [Fe(II)cytochrome c] + butanal + 2 H(+) => 2 [Fe(III)cytochrome c] + butan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855648", "l": "SALM3 binds LAR-RPTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41392", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937029", "l": "IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534365", "l": "Slo3 Potassium Transport (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987223", "l": "IL10RB binds TYK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.19"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46162", "l": "a quinol + NAD(+) => a quinone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37795", "l": "2 H(+) + 2 NADPH + O2 = 2 H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2534096", "l": "METAP1/2 demethylates GNAT1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44475", "l": "1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> 1-O-alkyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12762", "l": "precorrin-3B + S-adenosyl-L-methionine => 3 H(+) + precorrin-4 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873926", "l": "IFNG dimer binds IFNGR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14575", "l": "5-dehydro-4-deoxy-D-glucarate + H2O => D-glucarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168886", "l": "Hemopexin binds Hemes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30400", "l": "alpha-carotene + O2 + reduced [NADPH--hemoprotein reductase] => alpha-cryptoxanthin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177926", "l": "Dephosphorylation of PAG by SHP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49347", "l": "2-hydroxyspirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2,2-dihydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033734", "l": "(R)-benzylsuccinyl-CoA dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23679", "l": "ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433955", "l": "Phosphorylation of IKKs complex by activated TAK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047847", "l": "deoxyuridine phosphorylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31671", "l": "dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine = dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.235", "l": "\"dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58261", "l": "H2O + O-(ADP-D-ribosyl)-L-tyrosyl-[protein] => ADP-D-ribose + L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29879", "l": "ATP + H2O + L-arginine(out) = ADP + H(+) + L-arginine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56620", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + H2O = 2,4,5-trichlorocyclohexa-2,5-dien-1-ol + chloride + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11235", "l": "3'-phosphoadenylyl sulfate + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30561", "l": "guanosine + H(+) + triphosphate => GTP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11612", "l": "H2O + L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + NADPH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40321", "l": "(2E)-tetracosenoyl-CoA + H2O2 => O2 + tetracosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.32", "l": "\"Glucomannan 4-beta-mannosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24771", "l": "7(1)-hydroxychlorophyllide a + NAD(+) <=> chlorophyllide b + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18414", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosaminyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672175", "l": "Autophosphorylation of PDGFR mutant dimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45669", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351936", "l": "Caspase-mediated cleavage of claspin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.8", "l": "\"Glucosamine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450348", "l": "Activated human JNKs migrate to nucleoplasm (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13068", "l": "ATP + H2O <=> ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61355", "l": "ATP + H2O + riboflavin(in) <=> ADP + H(+) + phosphate + riboflavin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9687638", "l": "MLKL binds IP4, IP5 and IP6  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389352", "l": "Translocation of Vav1 to CD28 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004141", "l": "dethiobiotin synthase activity"}, {"i": "MetaCyc:DETHIOBIOTIN-SYN-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373724", "l": "Nephrin binds NCK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990890", "l": "netrin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60681", "l": "(+)-artemisinic aldehyde + H2O + NADP(+) => (+)-artemisinate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944236", "l": "Association of procollagen type XIV (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49116", "l": "H(+) + NADPH + O2 + protodeoxyviolaceinate = deoxyviolaceinate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944457", "l": "MAF1 translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28433", "l": "D-allose 6-phosphate <=> D-allulose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005130", "l": "granulocyte colony-stimulating factor receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52878", "l": "16beta,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP => 16beta,17beta-estriol + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140840", "l": "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683669", "l": "E protein gets N-glycosylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54274", "l": "(3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate => 2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31562", "l": "L-galactose + NAD(+) <=> H(+) + L-galactono-1,4-lactone + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198599", "l": "AKT phosphorylates MDM2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031768", "l": "ghrelin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22902", "l": "diacetyl + H(+) + NADH => (R)-acetoin + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672969", "l": "Phosphorylation of RAF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36701", "l": "8-desmethylnovobiocic acid + AMP + diphosphate => 3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42130", "l": "a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176879", "l": "apolipoprotein(a) + LDL => Lp(a) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928604", "l": "SFKs phosphorylate VAV2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17838", "l": "2-carboxy-D-arabinitol 1-phosphate + H2O => 2-carboxy-D-arabinitol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33987", "l": "(+)-copalyl diphosphate = diphosphate + neoabietadiene"}, {"i": "EC:4.2.3.132", "l": "\"Neoabietadiene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801101", "l": "RABGGTA binds RABGGTB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51648", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] + O2 = (S)-2-amino-6-oxohexanoyl-[protein] + acetamide + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032557", "l": "pyrimidine ribonucleotide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60742", "l": "(S)-(-)-citronellate + 2 H(+) + NADPH => (S)-(-)-citronellal + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31023", "l": "squalene = dammara-20,24-diene"}, {"i": "EC:5.4.99.37", "l": "\"Dammaradiene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50731", "l": "(Z)-(4-hydroxyphenyl)acetaldehyde oxime <=> 4-hydroxyphenylacetonitrile + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44476", "l": "1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192061", "l": "CYP46A1 24-hydroxylates CHOL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875183", "l": "CBL monoubiquitinates activated MET (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63477", "l": "NADP(+) + prostaglandin E2 => 15-oxoprostaglandin E2 + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947514", "l": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008412", "l": "CDK4 phosphorylates RUNX2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213244", "l": "Loading of antigenic peptides (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29226", "l": "menaquinone-8 + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + menaquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692764", "l": "MAPK6 binds CCND3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022073", "l": "Procollagen triple helix formation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434989", "l": "SEMA7A binds to PLXNC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702508", "l": "FLT mutants bind type I TKIs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25034", "l": "all-trans-retinol + NADP(+) => all-trans-retinal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103007", "l": "indole-3-acetate carboxyl methyltransferase activity"}, {"i": "RHEA:36131", "l": "(indol-3-yl)acetate + S-adenosyl-L-methionine = methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.278", "l": "\"Indole-3-acetate O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606807", "l": "Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166538", "l": "The bound receptor dimerizes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10958", "l": "H2O + NADP(+) + trans-2-coumarate => (E)-cinnamate + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49018", "l": "2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one => aurachin C epoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12473", "l": "H2O + N-ethylglycine + O2 => ethylamine + glyoxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1067659", "l": "Assembly of hexameric IL-6 receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12010", "l": "[G-protein-coupled receptor]-phosphate + ADP + H(+) => [G-protein-coupled receptor] + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008961", "l": "phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41430", "l": "3-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine => L-tyrosine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5658430", "l": "NF1 is degraded by the proteasome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11156", "l": "H2O + L-valine + NADP(+) = 3-methyl-2-oxobutanoate + H(+) + NADPH + NH4(+)"}, {"i": "EC:1.4.1.8", "l": "\"Valine dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12840", "l": "ATP + choline <=> ADP + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.83", "l": "\"Oligopeptidase B\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980039", "l": "NOTCH1 binds DLL1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34540", "l": "S-adenosyl-L-methionine + tellurite => methanetellurite + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853319", "l": "FGFR2 fusions dimerize (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218815", "l": "p-6Y-VEGFR2 binds NCK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099579", "l": "G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43795", "l": "adenosine(645) in 25S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(645) in 25S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668481", "l": "Protesomal degradation of K48polyUb-TRAF3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296326", "l": "HCAR1 binds LACT (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23086", "l": "7-methyl-3-oxooct-6-enoyl-CoA + acetate => 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42711", "l": "guanosine(46) in tRNA + S-adenosyl-L-methionine <=> N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59697", "l": "D-cellotetraono-1,5-lactone + H2O => D-cellotetraonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008201", "l": "heparin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632039", "l": "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869580", "l": "DEK binds TFAP2A homodimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003904", "l": "deoxyribodipyrimidine photo-lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47958", "l": "H(+) + maleate + pyruvate => 3-maleylpyruvate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033910", "l": "glucan 1,4-alpha-maltotetraohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6805061", "l": "CK2 binds FACT (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103080", "l": "methylthiopropylmalate isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63582", "l": "20-hydroxyecdysone + phosphate => 20-hydroxyecdysone 22-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177937", "l": "Phosphorylation of EGFR by SRC kinase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27299", "l": "2-formylbenzoate + H2O + NAD(+) => 2 H(+) + NADH + phthalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418868", "l": "Recruitment of Src and Fyn to DCC:FADK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175258", "l": "2-LTR formation due to circularization of viral DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173723", "l": "C8 binds C5b:C6:C7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51207", "l": "6-trans-leukotriene B4 + NADP(+) <=> 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046936", "l": "2'-deoxyadenosine deaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13980", "l": "D-serine <=> NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070892", "l": "lipoteichoic acid immune receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39115", "l": "4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NAD(+) = 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005527", "l": "macrolide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419334", "l": "Melatonin receptors can bind melatonin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211983", "l": "CYP2J2 oxidises ARA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33157", "l": "a 1-acyl-sn-glycerol + phosphate => a 1-acyl-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61108", "l": "(2R,3R)-dihydrokaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (2R,3R)-dihydromyricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41612", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O = D-ribose 2,5-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697084", "l": "Defective rpoB in Mtb RNAP transcribes RNA polyanion (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376140", "l": "Ena/VASP proteins bind ROBO1:SLIT2 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61659", "l": "(2E,6E)-farnesol + ATP <=> (2E,6E)-farnesyl phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9626816", "l": "PIN1 binds p-S345-NCF1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57334", "l": "3 3-oxopropanoate + 3 H(+) + H2O2 + 2 nitrate + nitrite => H2O + 3 O2 + 3 propionate 3-nitronate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043861", "l": "agmatine:putrescine antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917987", "l": "TFRC dimer binds 2xholoTF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32221", "l": "gamma-carotene => all-trans-lycopene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32243", "l": "alpha-D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate"}, {"i": "EC:5.3.1.29", "l": "\"Ribose 1,5-bisphosphate isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000263", "l": "TCII:Cbl is degraded to release Cbl (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14814", "l": "L-2-aminohexano-6-lactam => D-2-aminohexano-6-lactam"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678925", "l": "NR3C1 binds NR3C1 agonists (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51408", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1370500", "l": "PRLR binds SCF beta-TrCP complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047154", "l": "methylmalonyl-CoA carboxytransferase activity"}, {"i": "MetaCyc:2.1.3.1-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40729", "l": "a 1-acylglycerone 3-phosphate + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13138", "l": "cycloartenol + S-adenosyl-L-methionine => cyclolaudenol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33729", "l": "a 1,2-diacyl-sn-glycerol + Ins-1-P-Cer(d18:0/2-OH-26:0) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxyhexacosanoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052836", "l": "inositol 5-diphosphate pentakisphosphate 5-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783880", "l": "PIPOX oxidises PPCA to P6C (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14158", "l": "H2O + triphosphate => diphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114354", "l": "SMAC binds XIAP:Caspase-7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12511", "l": "loganate + S-adenosyl-L-methionine <=> loganin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183052", "l": "CBL binds to GRB2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17910", "l": "(S)-lactate => acetaldehyde + formate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5490230", "l": "AFXBO-SG, AFNBO-SG translocate from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31994", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + sesquithujene"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0043120", "l": "tumor necrosis factor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850961", "l": "PREX2 binds PTEN and inhibits it (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141439", "l": "Release of activated MAD2 from kinetochores (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.7", "l": "\"D-glutamate oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0042577", "l": "lipid phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379387", "l": "COMT transfers Met to DA to form 3MT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004552", "l": "octanol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983144", "l": "Transport of Antigen peptide in to ER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20141", "l": "an S-alkyl-L-cysteine S-oxide = 2-aminoprop-2-enoate + an S-alkyl sulfenate"}, {"i": "RHEA:54688", "l": "alliin = 2-aminoprop-2-enoate + allylsulfenate"}, {"i": "EC:4.4.1.4", "l": "\"Alliin lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36900", "l": "guanosine(37) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24456", "l": "alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21535", "l": "ATP + glutathione + glutathionylspermidine <=> ADP + H(+) + phosphate + trypanothione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22130", "l": "(1S,4S)-camphor + H(+) + NADH => (1S,2R,4S)-borneol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46080", "l": "(2E)-tetracosenoyl-CoA + H(+) + NADH = NAD(+) + tetracosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684248", "l": "SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52341", "l": "a long-chain fatty acyl-AMP + holo-[mycocerosate synthase] => AMP + H(+) + long-chain fatty acyl-[mycocerosate synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399711", "l": "Activation of Ca impermeable AMPA receptors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.68", "l": "\"Isoamylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814374", "l": "Kazrin binds periplakin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209973", "l": "Tyrosine is diiodinated (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61584", "l": "cytidine(72) in tRNA(Cys) + S-adenosyl-L-methionine = 5-methylcytidine(72) in tRNA(Cys) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15417", "l": "L-arogenate + NADP(+) = CO2 + L-tyrosine + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19801", "l": "ATP + D-pantetheine 4'-phosphate + H(+) = 3'-dephospho-CoA + diphosphate"}, {"i": "EC:2.7.7.3", "l": "\"Pantetheine-phosphate adenylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28196", "l": "3-sulfopyruvate + H(+) + NADH => (S)-3-sulfolactate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17617", "l": "leukotriene C4 = glutathione + leukotriene A4"}, {"i": "EC:4.4.1.20", "l": "\"Leukotriene-C(4) synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445084", "l": "Phosphorylation of L1 by SRC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9619355", "l": "CaMKK autophosphorylates in the cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981621", "l": "C3 convertases spontaneously dissociate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.15.5", "l": "\"Peptidyl-dipeptidase Dcp\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57513", "l": "chlorobenzene + H(+) + NADH + O2 => (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430183", "l": "NCK binds PAK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047682", "l": "aryl-alcohol oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19134", "l": "2-oxoglutarate + 3,3',5-triiodo-L-thyronine => 3,5,3'-triiodothyropyruvate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13077", "l": "an acyl phosphate + D-hexose = a carboxylate + D-hexose phosphate + H(+)"}, {"i": "EC:2.7.1.61", "l": "\"Acyl-phosphate--hexose phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47482", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => deoxycholate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37683", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA = 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015139", "l": "alpha-ketoglutarate transmembrane transporter activity"}, {"i": "REACT:R-HSA-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41096", "l": "H2O + sphing-4-enine-phosphocholine => H(+) + phosphocholine + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42790", "l": "2'-O-methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19943", "l": "coclaurine + H(+) + S-adenosyl-L-homocysteine => norcoclaurine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659755", "l": "Defective SLC6A18 does not transport Gly from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404135", "l": "RBP4 binds atROL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3318415", "l": "ATF2 acetylates histone H2B, H4 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878914", "l": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59291", "l": "beta-D-glucosyl-(1<->1)-sphing-4-enine + H2O <=> D-glucose + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5627072", "l": "RHOQ binds GOPC:CFTR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917841", "l": "Acidification of Tf:TfR1 containing endosome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34847", "l": "7,8-dihydromonapterin + H(+) + NADPH = 5,6,7,8-tetrahydromonapterin + NADP(+)"}, {"i": "EC:1.5.1.50", "l": "\"Dihydromonapterin reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38233", "l": "1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA => (9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-168136", "l": "Activated JNKs phosphorylate c-JUN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3321805", "l": "NSL acetylates histone H4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102826", "l": "kaempferol-3-glucoside-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-8270"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9007539", "l": "CHEK1 phosphorylates E2F6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.1", "l": "\"Carboxypeptidase A\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196773", "l": "COASY phosphorylates DP-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45827", "l": "H(+) + L-serine <=> CO2 + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013021", "l": "GDIs block activation of RHOB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35224", "l": "2-oxo-dADP + H2O => 2-hydroxy-dAMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047423", "l": "N-methylhydantoinase (ATP-hydrolyzing) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928654", "l": "Clathrin internalises EPH:EFN complexes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209815", "l": "Tyrosine is monoiodinated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27784", "l": "4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-octaprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-451033", "l": "(S)-Malate <=> Fumarate + H2O (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20783", "l": "ATP + GMP <=> ADP + GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382553", "l": "ABCA7:Apo1A-mediated phospholipid efflux (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030955", "l": "potassium ion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33767", "l": "a 3-hydroxy-fatty acyl-CoA = a (2E)-enoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173636", "l": "Formation of classic pathway C5 convertase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051120", "l": "hepoxilin A3 synthase activity"}, {"i": "REACT:R-HSA-2161794", "l": "Arachidonic acid is converted to HXA3/B3 by ALOX12 (Homo sapiens)"}, {"i": "REACT:R-HSA-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30199", "l": "2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate = 2 ATP + benzoyl-CoA + 2 H2O + reduced 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029454", "l": "Autophosphorylation of PAK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25569", "l": "ATP + beta-D-ribosylnicotinate => ADP + H(+) + nicotinate beta-D-ribonucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31035", "l": "arabidiol = (S)-2,3-epoxysqualene + H2O"}, {"i": "EC:4.2.1.124", "l": "\"Arabidiol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982017", "l": "Active G alpha (q) binds RGS proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709883", "l": "BIL:ALB scavenges O2.- (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30645", "l": "hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate => phosphate + S-methyl-5'-thioinosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607757", "l": "K63polyUb-TRAF6 ubiquitinates TAK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64318", "l": "2 (+)-geodin + 2 H2O => 2 dihydrogeodin + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46081", "l": "(2E)-tetracosenoyl-CoA + H(+) + NADH => NAD(+) + tetracosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55273", "l": "11-cis-retinol + tetradecanoyl-CoA => 11-cis-retinyl tetradecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417820", "l": "P2Y9 receptor can bind to LPA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706350", "l": "FLT3 phosphorylates CBL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977228", "l": "Sialyltransferase I can add sialic acid to the T antigen at the alpha 6 position (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31581", "l": "(5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate => (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052619", "l": "coenzyme F420-1:gamma-L-glutamate ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.151"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800870", "l": "NDUF subunits bind to form the FP subcomplex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15959", "l": "2-dehydro-3-deoxy-D-gluconate + H2O => D-altronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432054", "l": "Aquaporin-1 passively transports water out of cell (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61260", "l": "H2O + L-glutamine + O2 = 2-oxoglutaramate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36840", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59097", "l": "monoglucosyl-enterobactin + UDP-alpha-D-glucose => diglucosyl-enterobactin + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250606", "l": "botD LC cleaves target cell VAMP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9677585", "l": "CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9679044", "l": "FKBP1A binds sirolimus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47365", "l": "a dodecanoate ester + H2O => an aliphatic alcohol + dodecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.n5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42458", "l": "5alpha-cholesta-8,24-dien-3beta-ol => 4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015138", "l": "fumarate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102813", "l": "UDP-D-glucose:cyanidin 3-(p-coumaroyl)-glucoside 5-O-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-8205"}]}
{"type": "biolink:MolecularActivity", "ic": "53.474485931266244", "identifiers": [{"i": "GO:0016757", "l": "glycosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34336", "l": "cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 22R-hydroxycholesterol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52952", "l": "lithocholate + UDP-alpha-D-glucuronate = lithocholoyl-24-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37094", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(10Z,13Z,16Z)-docosatrienoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22451", "l": "ATP + pseudouridine <=> ADP + H(+) + psi-UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.9", "l": "\"Tripeptidyl-peptidase I\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23908", "l": "2 [methionine synthase]-methylcob(III)alamin + H(+) + NADP(+) + 2 S-adenosyl-L-homocysteine = 2 [methionine synthase]-cob(II)alamin + NADPH + 2 S-adenosyl-L-methionine"}, {"i": "EC:1.16.1.8", "l": "\"[Methionine synthase] reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48524", "l": "ganglioside GP1c + H2O = ganglioside GQ1c + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9656947", "l": "OGG1beta translocates to mitochondria (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-167429", "l": "The receptor:G-protein complex  binds GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157124", "l": "NOTCH3 binds JAG2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56632", "l": "H2O + neryl diphosphate = 1,8-cineole + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008804", "l": "carbamate kinase activity"}, {"i": "RHEA:10152", "l": "ATP + hydrogencarbonate + NH4(+) = ADP + carbamoyl phosphate + H(+) + H2O"}, {"i": "EC:2.7.2.2", "l": "\"Carbamate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31532", "l": "2-oxoglutarate + L-arginine + O2 => CO2 + N(omega)-hydroxy-L-arginine + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49519", "l": "2-oxoglutarate + N(1)-methyladenosine in mRNA + O2 <=> adenosine in mRNA + CO2 + formaldehyde + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31083", "l": "H2O + N-acetyl-D-muramoyl-L-alanine = L-alanine + N-acetyl-D-muramate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72139", "l": "Formation of the active Spliceosomal C (B*) complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9015111", "l": "Factor Xa inhibitors binds Xa (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20069", "l": "(Z)-phenylacetaldehyde oxime = H2O + phenylacetonitrile"}, {"i": "EC:4.99.1.7", "l": "\"Phenylacetaldoxime dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62834", "l": "GDP + H(+) + methyl 8-{[alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc]oxy}nonanoate => GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43350", "l": "cholesteryl (9Z-octadecenoate)(out) => cholesteryl (9Z-octadecenoate)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114352", "l": "Sequestration of tBID by BCL-2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20443", "l": "3-sulfino-L-alanine + H(+) => L-cysteine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798748", "l": "Exocytosis of secretory granule lumen proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51799", "l": "deoxycohumulone + dimethylallyl diphosphate <=> colupulone + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57432", "l": "3-methoxycatechol + O2 + reduced [NADH--hemoprotein reductase] = 1,2,3-trihydroxybenzene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12812", "l": "4 catechol + 3 O2 <=> 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33695", "l": "C20 sphinganine + NADP(+) = 3-oxoeicosasphinganine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63239", "l": "ATP + streptomycin <=> 6-O-adenylylstreptomycin + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59836", "l": "H2O + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein] = 3-deoxyglucosone + L-lysyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61255", "l": "H2O + L-valine + O2 <=> 3-methyl-2-oxobutanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019159", "l": "nicotinamide-nucleotide amidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166168", "l": "TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112120", "l": "Oxidative demethylation of 3-meC damaged DNA by ALKBH2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5681987", "l": "LC3 is cleaved by ATG4 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61228", "l": "H2O + L-histidine + O2 = 3-(imidazol-5-yl)pyruvate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937419", "l": "CBR3 reduces DOX to DOXOL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388828", "l": "PD-1 binds B7DC and B7H1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2301205", "l": "SETD8 monomethylates histone H4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18825", "l": "[(1->6)-alpha-D-glucosyl](n) + sucrose = [(1->6)-alpha-D-glucosyl](n+1) + D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58389", "l": "4-aminobenzoate + all-trans-hexaprenyl diphosphate => 4-amino-3-all-trans-hexaprenylbenzoate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350578", "l": "NQO1 interaction with ODC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48493", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + UDP-alpha-D-galactose => 1,2-di-(9Z,12Z-octadecadienoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202969", "l": "Caspase mediated cleavage of beta-catenin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23947", "l": "(E)-coniferol + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-trans-coniferol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38645", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) => 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30750", "l": "FAD + H(+) + hexadecanoyl-CoA <=> (2E)-hexadecenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247569", "l": "PADI4 deiminates Histones (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27278", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853313", "l": "FGFR2 fusions autophosphorylate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0004084", "l": "branched-chain-amino-acid transaminase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004517", "l": "nitric-oxide synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40543", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176700", "l": "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32467", "l": "2 S-adenosyl-L-methionine + sarcosine = glycine betaine + 2 H(+) + 2 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.157", "l": "\"Sarcosine/dimethylglycine N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15823", "l": "2 AH2 + CO2 + hydrogen cyanide => 2 A + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65316", "l": "2-oxoglutarate + chrodrimanin H + O2 = chrodrimanin E + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "64.109383204808623", "identifiers": [{"i": "GO:0005216", "l": "ion channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11009", "l": "a 5'-end triphospho-(purine-ribonucleoside) in mRNA + H2O => a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.69"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709098", "l": "DHFR dimer reduces FOLA to DHF (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050281", "l": "serine-glyoxylate transaminase activity"}, {"i": "RHEA:19125", "l": "glyoxylate + L-serine = 3-hydroxypyruvate + glycine"}, {"i": "EC:2.6.1.45", "l": "\"Serine--glyoxylate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664918", "l": "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:GAB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-481010", "l": "Surface deployment of platelet dense granule membrane components (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928615", "l": "EFNBs bind SFKs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018826", "l": "RHOT2 hydrolyzes GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44183", "l": "2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350901", "l": "Iodide is organified (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35833", "l": "2'-dehydrokanamycin A + CO2 + NH4(+) + succinate => 2-oxoglutarate + kanamycin B + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614544", "l": "Sulfite is oxidized to sulfate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17168", "l": "alpha-D-galactose 1-phosphate + dTTP + H(+) <=> diphosphate + dTDP-D-galactose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015190", "l": "L-leucine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450494", "l": "HuR binds mRNAs in the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390846", "l": "D2D3,4 bind to DA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58447", "l": "N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21868", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)"}, {"i": "EC:3.5.4.26", "l": "\"Diaminohydroxyphosphoribosylaminopyrimidine deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37624", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60429", "l": "(indol-3-yl)acetyl-L-aspartate + H2O => (indol-3-yl)acetate + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17262", "l": "a phenyl sulfate + H2O => a phenol + H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102944", "l": "medicagenate UDP-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-9035"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54220", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene = all-trans-neurosporene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44833", "l": "(R)-carnitine + tetradecanoyl-CoA => CoA + O-tetradecanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614669", "l": "FASLG gene expression is stimulated by FOXO1,FOXO3,(FOXO4) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43377", "l": "5'-deoxyinosine + phosphate => 5-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390438", "l": "FAR2 reduces PalmCoA to HXOL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21885", "l": "H2O + trithionate => H(+) + sulfate + thiosulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46631", "l": "3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH <=> androst-5-en-3beta,17beta-diol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985943", "l": "p-Y701-STAT1 dimerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.47"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16774", "l": "ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose => ganglioside GM1 (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810357", "l": "Fillagrin and keratin intermediate filaments polymerise forming a network (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783670", "l": "CRLF1 binds CLCF1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65106", "l": "aculene B + holo-[peptidyl-carrier protein] => aculene D + L-prolyl-[peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44846", "l": "CoA + O-eicosanoyl-(R)-carnitine => (R)-carnitine + eicosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32029", "l": "(-)-alpha-cuprenene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683840", "l": "SFTPB gene produces pro-SFTPB protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69068", "l": "RFC dissociates after sliding clamp formation (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51996", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + O2 + reduced [NADPH--hemoprotein reductase] = a 1-(methylsulfanyl)-4-aci-nitroalkane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2169050", "l": "SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.2", "l": "\"Ribonuclease alpha\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.22", "l": "\"UMP kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202489", "l": "Oligomerization of Bcl10 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73892", "l": "MGMT/hAGT mediated DNA Damage Reversal (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49102", "l": "5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester => H2O + Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30210", "l": "H2O + methylamine + 2 oxidized [amicyanin] <=> formaldehyde + 2 H(+) + NH4(+) + 2 reduced [amicyanin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430308", "l": "PARVB interacts with Alpha-actinin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709883", "l": "BIL:ALB scavenges O2.- (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48577", "l": "4-chlorocatechol + O2 => 3-chloro-cis,cis-muconate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30478", "l": "H2O + oroxylin A 7-O-beta-D-glucuronate <=> D-glucuronate + H(+) + oroxylin A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45645", "l": "H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine => H(+) + N-hexadecanoylsphing-4-enine + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956025", "l": "AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51265", "l": "4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] => (10bS,4aR)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54261", "l": "2-oxoglutarate + L-asparaginyl-[protein] + O2 => (3S)-3-hydroxy-L-asparaginyl-[protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14520", "l": "(E)-feruloyl-CoA + H2O <=> 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051007", "l": "squalene-hopene cyclase activity"}, {"i": "RHEA:17637", "l": "squalene = hop-22(29)-ene"}, {"i": "EC:5.4.99.17", "l": "\"Squalene--hopene cyclase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3134914", "l": "Beta-catenin migrates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61844", "l": "solasodine + UDP-alpha-D-glucose = H(+) + solasodine 3-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798372", "l": "ATM phosphorylates DYRK2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13101", "l": "4-imidazolone-5-propanoate = H2O + trans-urocanate"}, {"i": "EC:4.2.1.49", "l": "\"Urocanate hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47323", "l": "(S)-3-amino-3-phenylpropanoate + 2-oxoglutarate <=> 3-oxo-3-phenylpropanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70272", "l": "PGM:Mg2+ isomerise G6P to G1P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29573", "l": "H(+)(out) + L-idonate(out) => H(+)(in) + L-idonate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27817", "l": "acetate(in) <=> acetate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2514865", "l": "cGMP dissociates from CNG channels (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672980", "l": "Dissociation of RAS:RAF complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66477", "l": "gypsogenate + UDP-alpha-D-glucose => gypsogenate 28-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60396", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O = Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19292", "l": "H2O + sucrose 6(F)-phosphate <=> phosphate + sucrose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66798", "l": "11-oxomiltiradiene + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59527", "l": "9S,10-epoxy-(10,12Z)-octadecadienoate + H(+) + L-aspartyl-[protein] <=> 9-O-10-oxo-(12Z)-octadecenoate L-aspartatyl ester-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12787", "l": "an aldose + H(+) + NADH => an alditol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56467", "l": "1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O <=> 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102672", "l": "fatty acid alpha-oxygenase activity"}, {"i": "MetaCyc:RXN-4121"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20804", "l": "2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) = H(+) + hydrogencarbonate + NADH + propanoyl-CoA"}, {"i": "EC:1.2.1.27", "l": "\"Methylmalonate-semialdehyde dehydrogenase (CoA acylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61085", "l": "(2S)-naringenin + 2-oxoglutarate + O2 => (2R,3R)-dihydrokaempferol + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11229", "l": "(2S)-flavan-4-ol + NADP(+) => (2S)-flavanone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28367", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosaminouronate => beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65992", "l": "calciol + hnu = 5,6-trans-vitamin D3"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004583", "l": "dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29478", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-cubenene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805640", "l": "AKT phosphorylates KAT6A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62667", "l": "(2'R)-atrovenetin + S-adenosyl-L-methionine <=> deoxyherqueinone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071424", "l": "rRNA (cytosine-N4-)-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209377", "l": "Polymeric PGN binds to PGRP-LCx at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76426", "l": "N-atom dealkylation of caffeine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16122", "l": "5,6-dihydrouracil + H2O => 3-(carbamoylamino)propanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39107", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate = (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21156", "l": "(2R)-2-phosphoglycerate + H2O = (R)-glycerate + phosphate"}, {"i": "EC:3.1.3.20", "l": "\"Phosphoglycerate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62884", "l": "O2 + 4 semiviriditoxin = 2 (M)-viriditoxin + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047914", "l": "gamma-glutamylhistamine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60347", "l": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65655", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontanoyl)-sphing-4-enine <=> a diacylglycerol + N-(32-(9Z,12Z-octadecadienoyloxy)-dotricontanoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24355", "l": "ethyl (R)-3-hydroxyhexanoate + NADP(+) <=> ethyl 3-oxohexanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55778", "l": "4-hydroxy-4-O-(beta-D-glucuronide)-all-trans-retinoate + H(+) + UDP => all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391157", "l": "p-4Y-SIRPA:CD47 binds SKAP2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211874", "l": "CYP2S1 4-hydroxylates atRA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102225", "l": "4,4'-diaponeurosporene desaturase activity"}, {"i": "RHEA:31407", "l": "all-trans-4,4'-diaponeurosporene + FAD + H(+) = all-trans-4,4'-diapolycopene + FADH2"}, {"i": "MetaCyc:RXN-12258"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22399", "l": "1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 <=> glycolaldehyde + guaiacol + H2O + vanillin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11257", "l": "H2O + limonin + UDP-alpha-D-glucose => glucosyl-limonin + 2 H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42774", "l": "N(7)-methylguanosine(1405) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(1405) in 16S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40829", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29823", "l": "chloride(in) = chloride(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9639286", "l": "RRAGC,D exchanges GTP for GDP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75891", "l": "Abortive Initiation After Second Transition (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39796", "l": "7beta-hydroxycholesterol(in) + ATP + H2O => 7beta-hydroxycholesterol(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854466", "l": "VLDLR binds RELN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12448", "l": "(R)-pantothenate + H2O = (R)-pantoate + beta-alanine"}, {"i": "EC:3.5.1.22", "l": "\"Pantothenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23070", "l": "6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+) => 6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.261", "l": "\"(4-hydroxyphenyl)alkanoate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871193", "l": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62271", "l": "(R)-2-hydroxy-3-methylbutyrate + NADP(+) <=> 3-methyl-2-oxobutanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42604", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202969", "l": "Caspase mediated cleavage of beta-catenin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52824", "l": "(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 = (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032843", "l": "hydroperoxide reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697085", "l": "RNAP transcribes Mtb RNA polyanion (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61923", "l": "(2R,4S)-ketoconazole(in) + ATP + H2O <=> (2R,4S)-ketoconazole(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59533", "l": "(S)-reticuline + S-adenosyl-L-methionine => (S)-codamine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909755", "l": "Mitochondrial uptake of (R)-3-aminoisobutyric acid (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42798", "l": "cholesteryl (9Z,12Z)-octadecadienoate + CoA => (9Z,12Z)-octadecadienoyl-CoA + cholesterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9609310", "l": "β-blockers bind ADRB1,2,3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44239", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.18"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17357", "l": "O2 + 2 R'C(R)SH = H2O2 + R'C(R)S-S(R)CR'"}, {"i": "EC:1.8.3.2", "l": "\"Thiol oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374723", "l": "Nociceptin receptor binds to nociceptin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-182594", "l": "Association of INK4 family proteins with CDK4/6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904931", "l": "MCM complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174058", "l": "Degradation of multiubiquitinated Cdh1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2471621", "l": "Endostatin degradation by cathepsins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632677", "l": "PTCH is internalized (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419861", "l": "Melanospin is stimulated by light (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218906", "l": "RIPK3 phosphorylates MLKL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44985", "l": "(R)-carnitine + 3-methylbutanoyl-CoA => CoA + O-3-methylbutanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450088", "l": "GLUT1 tetramer binds 4xATP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70420", "l": "HK1,2,3,GCK phosphorylate Glc to form G6P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55675", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine <=> 4-O-([2-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14836", "l": "(R)-mevalonate + CoA + 2 NAD(+) <=> (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2169046", "l": "Degradation of TGF-beta receptor complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55110", "l": "(3R)-hydroxynonanoyl-[ACP] + NADP(+) => 3-oxononanoyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40150", "l": "eicosanoyl-CoA + H2O <=> CoA + eicosanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37885", "l": "acetate + oxalyl-CoA => acetyl-CoA + oxalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788623", "l": "p-Y-STATs translocate to nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26343", "l": "H(+) + L-methionine + Se-methyl-L-selenocysteine => L-selenocysteine + S-methyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614271", "l": "Autocleavage of ADGRG6 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35172", "l": "H(+)(out) + novobiocin(in) => H(+)(in) + novobiocin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173636", "l": "Formation of classic pathway C5 convertase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49236", "l": "N(pros)-phospho-L-histidyl-[protein](out) + sucrose = L-histidyl-[protein] + sucrose 6(G)-phosphate(in)"}, {"i": "EC:2.7.1.211", "l": "\"Protein-N(pi)-phosphohistidine--sucrose phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37944", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784765", "l": "p-Y705-STAT3 dimerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1461971", "l": "Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120021", "l": "oxysterol transfer activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013157", "l": "CDC42 binds effectors at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202203", "l": "Recruitment of PI3K to plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35945", "l": "deoxybrevianamide E + diphosphate => brevianamide F + dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785181", "l": "LMF1,2 bind LIPC dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015119", "l": "hexose phosphate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080054", "l": "low-affinity nitrate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29911", "l": "ATP + H2O + N-acetyl-D-glucosamine(in) = ADP + H(+) + N-acetyl-D-glucosamine(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46537", "l": "(6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388817", "l": "ICOS binds ICOSL/B7-H2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54134", "l": "a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose 6-phosphate + H(+) => a ribonucleoside 5'-diphosphate-alpha-D-glucose + D-glucose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004055", "l": "argininosuccinate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20408", "l": "H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate <=> (2S,6S)-2,6-diaminoheptanedioate + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800798", "l": "The PIDDosome binds CASP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18843", "l": "2-hydroxy-3-oxopropanoate + H(+) + NADPH => (R)-glycerate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981809", "l": "ST6GALNAC3/4 can add a sialic acid to the sialyl T antigen to form the disialyl T antigen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218821", "l": "PDK1 phosphorylates PKC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64692", "l": "isobutanol + NAD(+) = 2-methylpropanal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033509", "l": "USP9X binds Ub:PEX5L (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141341", "l": "SMOX-3 oxidises SPN to SPM (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106239", "l": "9,13-epoxylabda-14-ene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72631", "l": "Formation of the cap-binding eIF4F complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357429", "l": "AXL autophosphorylates on Y772 and Y814 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64540", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base"}, {"i": "EC:2.7.1.228", "l": "\"Mannosyl-inositol-phosphoceramide inositolphosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64255", "l": "glycine + tetradecanoyl-CoA <=> CoA + H(+) + N-tetradecanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12461", "l": "(S)-malate => fumarate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45280", "l": "12-(phosphooxy)octadecanoate + H2O = 12-hydroxyoctadecanoate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3159259", "l": "MMAA:MUT binds AdoCbl (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676589", "l": "RANKL,sRANKL trimer binds RANK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17002", "l": "amidinoproclavaminate + H2O => proclavaminate + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3965450", "l": "DAAM1 recruits PFN1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043183", "l": "vascular endothelial growth factor receptor 1 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31368", "l": "2 H(+) + 3 nitrite => H2O + nitrate + 2 nitric oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63659", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine <=> 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202216", "l": "Phosphorylation of SLP-76 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17847", "l": "5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH => 5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381217", "l": "IRE1:BiP dissociates in response to unfolded protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391872", "l": "NCAM1 cis-homophilic interaction (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28385", "l": "H2O + N(6)-(6-phospho-D-fructosyl)-L-lysine <=> D-glucose 6-phosphate + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607736", "l": "MALT1 oligomerizes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390912", "l": "HRH1 binds hist (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65420", "l": "GMP(in) + NAD(+)(out) = GMP(out) + NAD(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17674", "l": "quercetin + S-adenosyl-L-methionine => 3',4',5,7-tetrahydroxy-3-methoxyflavone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60151", "l": "(L-glutamyl)n-L-gamma-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate <=> (L-glutamyl)n+1-L-gamma-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37612", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005476", "l": "carnitine:acyl carnitine antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26148", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033703", "l": "3beta-hydroxy-5beta-steroid dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9691174", "l": "RAC1 binds effectors at the ER membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22876", "l": "(R)-mandelamide + H2O = (R)-mandelate + NH4(+)"}, {"i": "EC:3.5.1.86", "l": "\"Mandelamide amidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64813", "l": "acetyl-CoA + S-(2-aminoethyl)-homocysteine => CoA + H(+) + S-(2-acetamidoethyl)-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202722", "l": "CD48 binds CD244 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63399", "l": "A + Fe(II)-heme i + H2O <=> AH2 + Fe(II)-hydroxyheme i"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694428", "l": "LMAN family proteins bind glycosylated cargo (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10172", "l": "(3R)-hydroxybutanoate dimer + H2O = 2 (R)-3-hydroxybutanoate + H(+)"}, {"i": "EC:3.1.1.22", "l": "\"Hydroxybutyrate-dimer hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33988", "l": "(+)-copalyl diphosphate => diphosphate + neoabietadiene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.6", "l": "\"Ribonuclease IV\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683663", "l": "N-glycan trimming of Spike (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624668", "l": "CEBPA binds CDKN1A (p21) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167153", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38653", "l": "(9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+) => 1,3-di-(9Z-octadecenoyl)-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870469", "l": "RGGT geranylgeranylates RAB proteins (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009452", "l": "SMURF1 gene expression is stimulated by RUNX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31281", "l": "(2Z,6E,10E)-geranylgeranyl diphosphate + diphosphate => (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641205", "l": "RSPO:LGR binds ZNRF3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12562", "l": "H(+) + hydroquinone O-beta-D-glucopyranoside + UDP => hydroquinone + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635842", "l": "ULK3 phosphorylates GLI (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61337", "l": "ATP + H2O + protoporphyrin IX(in) => ADP + H(+) + phosphate + protoporphyrin IX(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047889", "l": "ferredoxin-nitrate reductase activity"}, {"i": "MetaCyc:1.7.7.2-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390438", "l": "FAR2 reduces PalmCoA to HXOL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654163", "l": "Activated FGFR4 binds PLCG1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983285", "l": "RAD51B binds RAD51C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17533", "l": "2-oxoglutarate + an aromatic L-alpha-amino acid = an aromatic oxo-acid + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977363", "l": "Factor H binds to C3bBb (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61078", "l": "(-)-echitovenine + CoA => (-)-minovincinine + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17224", "l": "dTDP-alpha-D-glucose <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29968", "l": "2'-deoxyuridine(in) + H(+)(in) => 2'-deoxyuridine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38519", "l": "1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-octadecanoylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38648", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62163", "l": "H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate <=> N-(9Z-octadecenoyl) ethanolamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43100", "l": "S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) = 2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.211", "l": "\"tRNA(Ser) (uridine(44)-2'-O)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28168", "l": "5-nitrosalicylate + NH4(+) => 5-nitroanthranilate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43298", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322429", "l": "XIAP monoubiquinates TLE (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45032", "l": "4 [Fe(III)cytochrome c] + H2O + hydroxylamine = 4 [Fe(II)cytochrome c] + 5 H(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30378", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-thujopsene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18660", "l": "(R)-glycerate + NADP(+) <=> 3-hydroxypyruvate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49553", "l": "H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] => H(+) + L-lysyl-[protein] + lactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139919", "l": "Translocation of BIM to mitochondria (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42612", "l": "a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n H(+)(out) + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102775", "l": "6-(4-methyl-2-oxopentyl)-4-hydroxy-2-pyrone synthase activity"}, {"i": "MetaCyc:RXN-7826"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690152", "l": "USP5 cleaves polyubiquitin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18356", "l": "ATP + H2O + K(+)(out) + Na(+)(in) <=> ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.134"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086200", "l": "Dentin matrix protein 1 binds integrin alphaVbeta3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66197", "l": "acetyl-CoA + tryptamine => CoA + H(+) + N-acetyltryptamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11742", "l": "glutathione disulfide + H(+) + NADPH => 2 glutathione + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19663", "l": "beta-D-fructose 6-phosphate + H(+) + NADH => D-mannitol 1-phosphate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32793", "l": "L-ectoine(out) => L-ectoine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3134962", "l": "DHX36 binds DNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45408", "l": "(2E)-dodecenoyl-CoA + H(+) + NADH = dodecanoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40588", "l": "H2O + octanedioyl-CoA => CoA + H(+) + octanedioate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047590", "l": "5-dehydro-2-deoxygluconokinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28897", "l": "cadaverine(out) + L-lysine(in) => cadaverine(in) + L-lysine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31503", "l": "beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphoenolpyruvate = 4,6-Me(COOH)C-beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphate"}, {"i": "EC:2.5.1.95", "l": "\"Xanthan pyruvate transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20162", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + sucrose => myo-inositol + raffinose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114284", "l": "Release of Cytochrome c from mitochondria (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102822", "l": "quercetin 3'-O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0015574", "l": "trehalose transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35567", "l": "H2O + N-(9Z,12Z-octadecadienoyl)-ethanolamine = (9Z,12Z)-octadecadienoate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709852", "l": "MAVS:TOMM70 recruits HSP90:TBK1:IRF3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28518", "l": "D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-beta-D-manno-heptose 1-phosphate + phosphate"}, {"i": "EC:3.1.3.82", "l": "\"D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59997", "l": "3-phenylpropanoate + H(+) + oxidized [electron-transfer flavoprotein] => (E)-cinnamate + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40316", "l": "glutaryl-CoA + O2 => (2E)-glutaconyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031517", "l": "red light photoreceptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42679", "l": "L-cysteine + L-histidine + O2 <=> H2O + L-alanin-3-yl L-histidin-5-yl sulfoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37490", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphocholine <=> 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41279", "l": "H2O + N-octadecanoylsphing-4-enine = octadecanoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35779", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = mutildienyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.132"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52652", "l": "lanosterol + S-adenosyl-L-methionine = 24-methylene-24-dihydrolanosterol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186773", "l": "PDGF dimer binds two receptors simultaneously (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36797", "l": "a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate => a ribonucleoside 5'-triphosphate + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645428", "l": "ALPK1 binds ADP-heptose (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54249", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50557", "l": "prostaglandin D2 => H2O + prostaglandin J2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16982", "l": "3-oxoadipate + NAD(+) => H(+) + maleylacetate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051736", "l": "polyribonucleotide 5'-hydroxyl-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23558", "l": "gamma-L-glutamyl-D-alanine + NH4(+) => D-alanine + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071886", "l": "1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442732", "l": "NMDA-activated RASGRF1 activates RAS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033458", "l": "GAC codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25105", "l": "ATP + pyridoxamine => ADP + H(+) + pyridoxamine 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61472", "l": "a sphingoid base + hexadecanoyl-CoA = an N-hexadecanoyl-sphingoid base + CoA + H(+)"}, {"i": "EC:2.3.1.291", "l": "\"Sphingoid base N-palmitoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209921", "l": "Monoiodinated tyrosine can be deiodinated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031844", "l": "type 4 neuropeptide Y receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112434", "l": "Formation of DSIF complex  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36022", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161293", "l": "Tropoelastin forms aggregate globules (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55268", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate = (R)-glycerate + alpha-D-glucose 1-phosphate"}, {"i": "EC:2.4.1.352", "l": "\"Glucosylglycerate phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1461993", "l": "pro-HD5 is cleaved by trypsin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2106625", "l": "Duplex siRNA is loaded into Argonaute (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-507869", "l": "Aquaporins passively transport glycerol into cells (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60222", "l": "CO2 + formaldehyde + L-lysyl(4)-[histone H3] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl(4)-[histone H3] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800315", "l": "MST1 binds MST1R (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51058", "l": "AH2 + androsta-1,4-diene-3,17-dione => A + androst-4-ene-3,17-dione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61739", "l": "steviolmonoside + UDP-alpha-D-glucose <=> rubusoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41410", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + N-(acetyl)-sphing-4-enine => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5632738", "l": "DDIT4 binds 14-3-3 dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390593", "l": "ATP Hydrolysis By Myosin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102444", "l": "isorhamnetin 3-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-13929"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60343", "l": "N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60871", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O <=> a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(7)-methyl-GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17796", "l": "H2O + L-alanyl-tRNA(Thr) <=> H(+) + L-alanine + tRNA(Thr)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901531", "l": "hypochlorite binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685230", "l": "CHEK1 phosphorylates RAD51 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-992696", "l": "p53, SIN3A and MYB form a complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4088134", "l": "PLK1 phosphorylates FOXM1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211968", "l": "CYP2W1 oxidises INDOL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660479", "l": "MTF1 dimer:12Zn2+ binds SNCB gene (beta-synuclein) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25515", "l": "(2S)-2-amino-4-deoxychorismate + L-glutamate <=> chorismate + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047926", "l": "geranyl-diphosphate cyclase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52500", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = (13R)-hydroxy-(9Z,11E)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21854", "l": "(9Z)-octadecenoate + H2O => (R)-10-hydroxyoctadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811427", "l": "COPI vesicle uncoating at the ER (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016402", "l": "pristanoyl-CoA oxidase activity"}, {"i": "REACT:R-HSA-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102972", "l": "gibberellin A12,2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A110-forming)"}, {"i": "MetaCyc:RXN-947"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45816", "l": "(S)-lactate + A = AH2 + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635839", "l": "ULK3:SUFU dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388809", "l": "CTLA-4 binds B7-1/B7-2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33167", "l": "2 a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycero-3-phospho-1D-myo-inositol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23421", "l": "alpha,alpha-trehalose 6-phosphate + H2O => alpha,alpha-trehalose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708557", "l": "FBXL17 binds BACH1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613513", "l": "PLINs:HSPA8 binds PRKAA2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042356", "l": "GDP-4-dehydro-D-rhamnose reductase activity"}, {"i": "EC:1.1.1.187", "l": "\"GDP-4-dehydro-D-rhamnose reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72180", "l": "Cleavage of mRNA at the 3'-end (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22866", "l": "D-lysine => L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57416", "l": "H2O + L-asparaginyl-[protein] = L-aspartyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-481009", "l": "Exocytosis of platelet dense granule content (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139895", "l": "tBID activates BAK protein (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64394", "l": "a dipeptide(in) + H(+)(in) => a dipeptide(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111966", "l": "GRK2 binds CALM1:4Ca2+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53825", "l": "NAD(+) + taurochenodeoxycholate => 7-oxotaurolithocholate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45010", "l": "octadecanoate + sphinganine => H2O + N-(octadecanoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.99.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160935", "l": "SMURF1 ubiquitinates RHOA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008677", "l": "2-dehydropantoate 2-reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16611", "l": "5-phospho-alpha-D-ribose 1-diphosphate + adenine => AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000263", "l": "TCII:Cbl is degraded to release Cbl (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022728", "l": "FKBP5 gene expression is inhibited by MECP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5213466", "l": "RIPK3 is phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015279", "l": "store-operated calcium channel activity"}, {"i": "REACT:R-HSA-434798", "l": "CRAC translocates calcium from the extracellular region to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201639", "l": "Caspase-mediated cleavage of GAS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944257", "l": "Association of procollagen type XXIV (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54686", "l": "(-)-kolavenyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50519", "l": "acetyl-CoA + N-terminal L-threonyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029270", "l": "Recruitment of PLCgamma to membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362437", "l": "C-terminal Hh fragments are bound by lectins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050342", "l": "tocopherol O-methyltransferase activity"}, {"i": "MetaCyc:TOCOPHEROL-O-METHYLTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57018", "l": "3,6-dichlorosalicylate + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 3,6-dichloro-2-methoxybenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944255", "l": "Association of procollagen type VII (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25226", "l": "L-arabinitol + NAD(+) => H(+) + L-arabinose + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15767", "l": "adenosylcob(III)inamide phosphate + GDP + H(+) => adenosylcob(III)inamide + GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56428", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8873923", "l": "STARD10 binds LPCAT1 and PC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56734", "l": "echinenone + H2O => 4,4-dihydroxy-all-trans-beta-carotene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696268", "l": "RND3 binds effectors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6813749", "l": "ALDH1A1 oxidises GA to DGA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41069", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43732", "l": "a triacyl-sn-glycerol + H2O = 1,3-diacyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210444", "l": "L-Glutamate loading of synaptic vesicle (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34025", "l": "(E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADH => 3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63290", "l": "9-hydroperoxy-(5Z,7E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218642", "l": "PTK2 autophosphorylates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.18"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62674", "l": "an N(6)-methyl-2'-O-methyladenosine in U2 snRNA + H(+) + S-adenosyl-L-homocysteine => a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016018", "l": "cyclosporin A binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2214351", "l": "PLK1 phosphorylates GORASP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50767", "l": "4-amino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine <=> 4-methylamino-4-dedimethylamino-anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27595", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 5 isopentenyl diphosphate => all-trans-nonaprenyl diphosphate + 5 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65151", "l": "phloretin + UDP-alpha-D-glucose <=> H(+) + trilobatin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53110", "l": "2-hydroxy-3-methoxy-estrone + H(+) + S-adenosyl-L-homocysteine => 2-hydroxyestrone + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140761", "l": "sequestered tissue factor -> tissue factor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35090", "l": "H2O + N'-monoacetylchitobiose-6'-phosphate <=> D-glucosamine + N-acetyl-D-glucosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47213", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45449", "l": "H2O + N-(dodecanoyl)-sphinganine => dodecanoate + sphinganine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047563", "l": "3-hydroxybenzoate 2-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013157", "l": "CDC42 binds effectors at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39961", "l": "glycerol + H(+) + hexadecanoate => 1-hexadecanoylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34057", "l": "6,8-dimethyl-6,7-didehydroergoline + H(+) + NADH => festuclavine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371527", "l": "HSF1 trimer translocates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48026", "l": "dipropanoylglycerol + H(+) + propanoate => 1,2,3-tripropanoylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698933", "l": "HCMV B Nucleocapsid Translocation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038117", "l": "C-C motif chemokine 19 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63439", "l": "1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + a di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39154", "l": "3-oxooctadecanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxyoctadecanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66011", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + H2O2 + L-methionyl-[collagen] <=> [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59021", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O => (9Z,12Z)-octadecadienoate + di-(9Z,12Z)-octadecadienoylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9634834", "l": "ACHEIs bind ACHE (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031826", "l": "type 2A serotonin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56373", "l": "3,4-dihydroxybenzoate + bromide + 2 H(+) + NADPH + O2 => 3-bromo-4,5-dihydroxybenzoate + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66896", "l": "4 O2 + ophiobolin F + 4 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 6 H2O + ophiobolin C + 4 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001042", "l": "RNA polymerase I core binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800870", "l": "NDUF subunits bind to form the FP subcomplex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35907", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199043", "l": "LILRs interact with MHC Class I (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15167", "l": "glyoxylate + H2O2 + methylamine => H2O + O2 + sarcosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42276", "l": "2-methylbutanoyl-CoA + H(+) + malonyl-[ACP] = 4-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65881", "l": "1-hydroxy-5alpha-androstan-3,17-dione + A => 5alpha-androstan-1,3,17-trione + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3318415", "l": "ATF2 acetylates histone H2B, H4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55018", "l": "7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+) => H(+) + menthone + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865774", "l": "TTLLs polyglutamylate tubulin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018804", "l": "RAC3 GEFs activate RAC3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35730", "l": "dodecanoyl-CoA + sn-glycerol 3-phosphate <=> 1-dodecanoyl-sn-glycerol 3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23619", "l": "1,2-dihydro-alpha-santonin + NADP(+) <=> alpha-santonin + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22669", "l": "2-N,3-O-bis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => H(+) + lipid A disaccharide (E. coli) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54513", "l": "peregrinol diphosphate => (13R)-9,13-epoxylabd-14-ene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602473", "l": "Autocatalytic activation of MMP1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047838", "l": "D-xylose 1-dehydrogenase (NAD) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871370", "l": "p-Y281,292-RUFY1 translocates from cytosol to early endosome membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58786", "l": "a 5'-triphospho-guanosine-ribonucleotide-snRNA + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + a 5'-methyltriphosphate-guanosine-ribonucleotide-snRNA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615910", "l": "SUMOylation of PCNA with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.12"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39785", "l": "(17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20637", "l": "D-fructose + D-glucose = D-glucono-1,5-lactone + D-sorbitol"}, {"i": "EC:1.1.99.28", "l": "\"Glucose-fructose oxidoreductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619430", "l": "PPM1E dephosphorylates CAMK4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-744886", "l": "The Ligand:GPCR:Gs complex dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379464", "l": "COMT transfers Met to DOPAC to form HVA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1028821", "l": "Dimerization of Phospho IRF3 or phospho IRF7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43127", "l": "guanosine(10) in tRNA + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106319", "l": "(R)-limonene 1,2-monooxygenase NADH activity"}, {"i": "RHEA:26093", "l": "(4R)-limonene + H(+) + NADH + O2 = H2O + limonene 1,2-epoxide + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38529", "l": "(9Z)-octadecenoate + 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + H(+) => 1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10338", "l": "D-threo-isocitrate => citrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68603", "l": "ORC5 binds ORC2:ORC3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45894", "l": "an N-acylsphing-4-enine 1-phosphoethanolamine + CMP + H(+) => an N-acylsphing-4-enine + CDP-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66366", "l": "6-methyl-3,7-dioxodecanedioyl-CoA => (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57541", "l": "5'-NTP-ribonucleotide-RNA + H2O => 5'-phospho-ribonucleosidyl-ribonucleotide-RNA + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12300", "l": "S-adenosyl-L-methionine + uridine(47) in tRNA(Phe) = 3-[(3S)-3-amino-3-carboxypropyl]uridine(47) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.n2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47915", "l": "6-deoxy-6-sulfo-D-gluconate <=> 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30187", "l": "(S)-dihydroorotate + a quinone = a quinol + orotate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25582", "l": "beta-L-fucose => alpha-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785594", "l": "FANCD2 binds FANCI (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15744", "l": "2,5-dichlorocyclohexa-2,5-dien-1,4-diol + NAD(+) <=> 2,5-dichlorohydroquinone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786118", "l": "IL13 binds IL13RA:TYK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46474", "l": "4alpha-hydroxymethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34613", "l": "H(+) + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + UDP => N-acyl-15-methylhexadecasphing-4-enine + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3076905", "l": "Extracellular BTD hydrolyses BCTN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158959", "l": "urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071949", "l": "FAD binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174624", "l": "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11996", "l": "biphenyl-2-ol + H(+) + NADH + O2 = biphenyl-2,3-diol + H2O + NAD(+)"}, {"i": "RHEA:63512", "l": "biphenyl-2,2'-diol + H(+) + NADH + O2 = biphenyl-2,2',3-triol + H2O + NAD(+)"}, {"i": "EC:1.14.13.44", "l": "\"2-hydroxybiphenyl 3-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52693", "l": "3-phenyllactate + NADP(+) => 3-phenylpyruvate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14216", "l": "ATP + beta-D-fructose 1-phosphate <=> ADP + beta-D-fructose 1,6-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45214", "l": "[methyl-Co(III) corrinoid Fe-S protein] + CO + CoA => [Co(I) corrinoid Fe-S protein] + acetyl-CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36146", "l": "(2E)-hexadecenoyl-CoA + H(+) + NADPH <=> hexadecanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8986258", "l": "SLIT2:ROBO1 binds CXCR4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34023", "l": "3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(+) = (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADH"}, {"i": "RHEA:34027", "l": "3,3'-bipyridine-2,2',5,5',6,6'-hexol + NADP(+) = (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADPH"}, {"i": "EC:1.1.1.328", "l": "\"Nicotine blue oxidoreductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295613", "l": "SPRY2 binds GRB2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102387", "l": "2-phenylethanol acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034450", "l": "ubiquitin-ubiquitin ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63457", "l": "(2E,6E,10E)-geranylgeraniol + CTP => (2E,6E,10E)-geranylgeranyl phosphate + CDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36722", "l": "hexacosenoyl-CoA + sphinganine <=> CoA + H(+) + N-hexacosenoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201608", "l": "Caspase-mediated cleavage of alpha adducin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8934446", "l": "Activated PKC phosphorylates SHC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23477", "l": "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) => (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8963734", "l": "IL9 binds IL9R:JAK1 and IL2RG:JAK3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624272", "l": "MMPs cleave HB-EGF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156907", "l": "Aminoacyl-tRNA  binds to the ribosome at the A-site (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43560", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28232", "l": "(+)-costunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63549", "l": "angiotensin-(1-9) + H2O => angiotensin-(1-7) + L-phenylalanyl-L-histidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093342", "l": "SDC2 multimerises (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1606807", "l": "Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65367", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O <=> a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791107", "l": "Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29630", "l": "alpha-maltohexaose + beta-maltose <=> alpha-maltoheptaose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798126", "l": "TP53 stimulates CASP6 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62590", "l": "4-hydroxybenzyl alcohol + CO2 => 2-hydroxy-2-(4-hydroxyphenyl)acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048045", "l": "trans-pentaprenyltranstransferase activity"}, {"i": "RHEA:22632", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + isopentenyl diphosphate = all-trans-hexaprenyl diphosphate + diphosphate"}, {"i": "KEGG.REACTION:R05613"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40237", "l": "coenzyme M-coenzyme B heterodisulfide + succinate => coenzyme B + coenzyme M + fumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14712", "l": "a 3-oxo-Delta(5)-steroid <=> a 3-oxo-Delta(4)-steroid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21749", "l": "(S)-lactaldehyde + NADP(+) => H(+) + methylglyoxal + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42701", "l": "6-carboxyhexanoyl-[ACP] methyl ester + H2O => 6-carboxyhexanoyl-[ACP] + H(+) + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33873", "l": "glyoxylate + NH4(+) + urea => (S)-2-ureidoglycine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13808", "l": "A + a 3-oxo-5alpha-steroid <=> a 3-oxo-Delta(4)-steroid + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38596", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632672", "l": "ADRBK1 phosphorylates SMO dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48354", "l": "GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-844619", "l": "AIM2 binds dsDNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40252", "l": "4-O-methylrhodomycin D + H2O => 10-carboxy-13-deoxydaunorubicin + H(+) + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948027", "l": "RNASEs bind bacterial phospholipids (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700662", "l": "(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58170", "l": "(-)-5-epi-eremophilene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036237", "l": "acyl-glucuronidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050246", "l": "questin monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53962", "l": "4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + FMN + H(+) + H2O => 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + FMNH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57431", "l": "anisole + O2 + reduced [NADH--hemoprotein reductase] <=> formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] + phenol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102301", "l": "gamma-linolenate elongase activity"}, {"i": "MetaCyc:RXN-12777"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416562", "l": "p190RhoGAP binds Plexin-B1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59679", "l": "D-maltotetraose + O2 <=> D-maltotetraono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938108", "l": "SERPINB13 binds cathepsin L (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5606996", "l": "Soluble PROCR binds activated protein C (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31217", "l": "(5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH => (5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.41", "l": "\"Cathepsin F\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5604929", "l": "Activated protein C binds Protein S (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22745", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210430", "l": "Release of L-Glutamate at the synapse (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12212", "l": "9H-fluoren-9-ol + NADP(+) = 9H-fluoren-9-one + H(+) + NADPH"}, {"i": "RHEA:12216", "l": "9H-fluoren-9-ol + NAD(+) = 9H-fluoren-9-one + H(+) + NADH"}, {"i": "EC:1.1.1.256", "l": "\"Fluoren-9-ol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39813", "l": "18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373707", "l": "Netrin-1 induced DCC clustering (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27421", "l": "(2E,6E)-farnesyl diphosphate = (3E,6E)-alpha-farnesene + diphosphate"}, {"i": "EC:4.2.3.46", "l": "\"Alpha-farnesene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32630", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9649735", "l": "Intrinsic nucleotide exchange on RAS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13619", "l": "5-(methylsulfanyl)-D-ribose + adenine => H2O + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52192", "l": "(E)-phenylacetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] = (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810076", "l": "DDO oxidizes D-Asp to OA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102487", "l": "dUTP phosphohydrolase activity"}, {"i": "MetaCyc:RXN-14199"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687284", "l": "DMBT1 binds SFTPD 12mer, SFTPAs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16654", "l": "D-gluconate + NADP(+) => 2-dehydro-D-gluconate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109639", "l": "Formation of the closed pre-initiation complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-481009", "l": "Exocytosis of platelet dense granule content (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22319", "l": "13-hydroxydocosanoate + UDP-alpha-D-glucose <=> 13-(beta-D-glucosyloxy)docosanoate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74994", "l": "Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39123", "l": "(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O = (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937050", "l": "Pellino ubiquitinates hp-IRAK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102572", "l": "N-glutamylanilide hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701556", "l": "IL2RG gene expression downstream of ALK signaling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57727", "l": "H(+) + 2 Na(+)(in) + oxaloacetate <=> CO2 + 2 Na(+)(out) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944497", "l": "PTEN mRNA translation is negatively regulated by microRNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877158", "l": "P2X7 forms oligomeric non-selective cation channels (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36892", "l": "(9Z,12Z)-octadecadienoyl-CoA + AH2 + O2 => (9Z,12Z,15Z)-octadecatrienoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008822", "l": "PPM1D dephosphorylates RUNX2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9706393", "l": "RHOBTB3 binds ATP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41644", "l": "2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA = 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate"}, {"i": "EC:6.2.1.43", "l": "\"2-hydroxy-7-methoxy-5-methyl-1-naphthoate--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1220614", "l": "Spontaneous dimerization of ligand-responsive EGFR mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63278", "l": "a 1-acyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36876", "l": "(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879930", "l": "STAT5 is recruited by JAK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042608", "l": "T cell receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42217", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) => 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016362", "l": "activin receptor activity, type II"}, {"i": "REACT:R-HSA-201443", "l": "Type II receptor phosphorylates type I receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000006", "l": "high-affinity zinc transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28393", "l": "N(6)-(D-psicosyl)-L-lysine <=> N(6)-(D-fructosyl)-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656269", "l": "Defective CHST6 does not transfer SO4(2-) to GlcNAc residues on keratan-PG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30512", "l": "2-demethylmenaquinone-8 + H(+) + NADPH => 2-demethylmenaquinol-8 + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53966", "l": "gamma-L-glutamyl-butirosin B + H(+) + holo-[BtrI ACP] => 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + ribostamycin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791186", "l": "Expression of ZBTB17 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050524", "l": "coenzyme-B sulfoethylthiotransferase activity"}, {"i": "KEGG.REACTION:R04541"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11890", "l": "a carboxylate + 2 H(+) + NADPH => an aldehyde + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64977", "l": "8-oxo-dGTP + 2 H2O => 8-oxo-dGMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17388", "l": "H2O + hypotaurine + NAD(+) <=> H(+) + NADH + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24967", "l": "calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> calcitetrol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112435", "l": "Formation of Elongin BC complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11506", "l": "H(+) + S-adenosyl-L-homocysteine + sterigmatocystin => 6-demethylsterigmatocystin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22631", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate <=> (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2530445", "l": "CD59 inhibits MAC formation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43723", "l": "juvenile hormone III carboxylate + S-adenosyl-L-methionine <=> juvenile hormone III + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23046", "l": "(E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63934", "l": "abscisate(out) + ADP + H(+) + phosphate => abscisate(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.57", "l": "\"O-sialoglycoprotein endopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009703", "l": "nitrate reductase (NADH) activity"}, {"i": "RHEA:17913", "l": "H2O + NAD(+) + nitrite = H(+) + NADH + nitrate"}, {"i": "EC:1.7.1.1", "l": "\"Nitrate reductase (NADH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682388", "l": "Autophagosome maturation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141341", "l": "SMOX-3 oxidises SPN to SPM (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070053", "l": "thrombospondin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40229", "l": "A47934 + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + desulfo-A47934"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375395", "l": "C5a receptor binds C5a anaphylatoxin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11248", "l": "[(3R)-hydroxybutanoate](n) + H2O = (R)-3-hydroxybutanoate + [(3R)-hydroxybutanoate](n-1) + H(+)"}, {"i": "EC:3.1.1.75", "l": "\"Poly(3-hydroxybutyrate) depolymerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36522", "l": "H(+) + hexacosanoyl-CoA + malonyl-CoA <=> 3-oxooctacosanyol-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43783", "l": "2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201457", "l": "BMP2 binds to the receptor complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983147", "l": "Release of E3 from polyubiquitinated substrate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65990", "l": "calciol => previtamin D3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54906", "l": "(9Z)-hexadecenoyl-[ACP] + NAD(+) => (2E,9Z)-hexadecadienoyl-[ACP] + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18098", "l": "pteridine-2,4,6,7-tetrol => H(+) + xanthine-8-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17912", "l": "(S)-lactate <=> acetaldehyde + formate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16086", "l": "ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990002", "l": "methylglyoxal reductase (NADPH-dependent, acetol producing)"}, {"i": "RHEA:27986", "l": "hydroxyacetone + NADP(+) = H(+) + methylglyoxal + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27723", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-4-deoxy-4-formamido-beta-L-arabinose => 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679775", "l": "COMT binds COMT Inhibitors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047665", "l": "aminolevulinate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47254", "l": "6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + progesterone + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17259", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + vomilenine => O2 + reduced [NADPH--hemoprotein reductase] + vinorine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18148", "l": "ATP + beta-D-fructose <=> ADP + beta-D-fructose 1-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21478", "l": "[(1->3)-beta-D-glucosyl](n+1) + H(+) + UDP => [(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247840", "l": "WLS binds WNT ligands in the Golgi (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66064", "l": "2-oxohexanoate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653957", "l": "Rag dimer formation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193668", "l": "p75NTR and RHOA-GDI interact (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20692", "l": "chlorogenate + H2O <=> (E)-caffeate + H(+) + L-quinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39223", "l": "(3R)-hydroxyoctacosanoyl-CoA = (2E)-octacosenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388981", "l": "The Kiss receptor GPR54 binds kisspeptin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61528", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base = a diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004844", "l": "uracil DNA N-glycosylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.11"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034844", "l": "naphthyl-2-methyl-succinate CoA-transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55992", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20528", "l": "ATP + ethylamine + L-glutamate <=> ADP + H(+) + N(5)-ethyl-L-glutamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24011", "l": "ATP + hypotaurocyamine <=> ADP + H(+) + N(omega)-phosphohypotaurocyamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47808", "l": "epothilone D + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = epothilone B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71825", "l": "G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694563", "l": "ABHD10 hydrolyses MPAG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30090", "l": "(S)-2-hydroxyglutarate + FAD + H(+) <=> 2-oxoglutarate + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61188", "l": "quercetin 3-O-beta-D-glucoside + UDP-beta-L-rhamnose = H(+) + quercetin 3-O-beta-D-glucoside-7-O-alpha-L-rhamnoside + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102995", "l": "angelicin synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357904", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696131", "l": "AOC1 deaminates Hist (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205286", "l": "GRB2:SOS interacts with p-KIT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051266", "l": "sirohydrochlorin ferrochelatase activity"}, {"i": "RHEA:24360", "l": "2 H(+) + siroheme = Fe(2+) + sirohydrochlorin"}, {"i": "EC:4.99.1.4", "l": "\"Sirohydrochlorin ferrochelatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-918225", "l": "TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351936", "l": "Caspase-mediated cleavage of claspin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64417", "l": "D-xylofuranose + NADP(+) => D-xylono-1,4-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53837", "l": "a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-acyl-alpha-D-glucosamine => a UDP-2-N,3-O-bis((3R)-3-hydroxyacyl)-alpha-D-glucosamine + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22142", "l": "a nucleoside + phosphate => a nucleoside 5'-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54535", "l": "H2O + N-(4-oxoglutaryl)-L-cysteinylglycine <=> 2-oxoglutarate + L-cysteinylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46777", "l": "a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047052", "l": "(S)-stylopine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174959", "l": "The acetyl group from acetyl-CoA is transferred to the NAT1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19977", "l": "3'-phosphoadenylyl sulfate + L-tyrosine methyl ester = adenosine 3',5'-bisphosphate + H(+) + L-tyrosine methyl ester 4-sulfate"}, {"i": "EC:2.8.2.9", "l": "\"Tyrosine-ester sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64062", "l": "1-phenyl-1,2-propanedione + H(+) + NADH => (S)-phenylacetylcarbinol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11565", "l": "4-O-beta-D-glucopyranosyl-D-gluconate + phosphate => alpha-D-glucose 1-phosphate + D-gluconate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70692", "l": "ornithine => putrescine + CO2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.2.12"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43551", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28263", "l": "3-alpha-D-mannopyranosyl-alpha-D-mannopyranose + UDP-alpha-D-xylose => 3-O-(6-O-alpha-D-xylosylphospho-alpha-D-mannopyranosyl)-alpha-D-mannopyranose + H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49149", "l": "dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine => dTDP-alpha-D-forosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015021", "l": "heparin-sulfate lyase activity"}, {"i": "MetaCyc:4.2.2.8-RXN"}, {"i": "EC:4.2.2.8", "l": "\"Heparin-sulfate lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13964", "l": "ATP + H2O + Mg(2+) + protoporphyrin IX <=> ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15627", "l": "Co-precorrin-6A + H(+) + NADH => Co-precorrin-6B + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033520", "l": "TYSND1 cleaves TYSND1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2512800", "l": "SCARB1:ligand is endocytosed (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983153", "l": "E1 mediated ubiquitin activation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-217255", "l": "FMO1:FAD N-oxidises TAM (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58617", "l": "N-octanoyl-(2S)-hydroxyglycine => glyoxylate + octanamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55710", "l": "[ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide => [ADP-thiazole synthase]-L-cysteine + glycine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10445", "l": "(S)-reticuline + S-adenosyl-L-methionine => (S)-laudanine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64899", "l": "2 H2O + UTP <=> 2 H(+) + 2 phosphate + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636375", "l": "SecA2 transports SapM from cytoplasm to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49586", "l": "L-erythrulose 1-phosphate => D-erythrulose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31909", "l": "(S)-coclaurine + H(+) + S-adenosyl-L-homocysteine => (S)-norcoclaurine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22097", "l": "phosphate + RNA(n+1) => a ribonucleoside 5'-diphosphate + RNA(n)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047977", "l": "hepoxilin-epoxide hydrolase activity"}, {"i": "RHEA:16665", "l": "(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate"}, {"i": "EC:3.3.2.7", "l": "\"Hepoxilin-epoxide hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39683", "l": "3-oxo-(11Z)-octadecenoyl-CoA + H(+) + NADPH = (R)-3-hydroxy-(11Z)-octadecenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47891", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40096", "l": "26-oxohexacosanoate + H2O + NAD(+) => 2 H(+) + hexacosanedioate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18038", "l": "agmatine + H2O => N-carbamoylputrescine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1449687", "l": "Corticosteroids bind to CBG in blood (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103055", "l": "gibberelli A15, 2-oxoglutarate:oxygen oxidoreductase activity"}, {"i": "RHEA:60780", "l": "2-oxoglutarate + gibberellin A15 + O2 = CO2 + gibberellin A24 + H2O + succinate"}, {"i": "MetaCyc:RXN1F-163"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60716", "l": "(1R,3R)-chrysanthemal + H2O + NADP(+) = (1R,3R)-chrysanthemate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0005231", "l": "excitatory extracellular ligand-gated ion channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17573", "l": "demethylmacrocin + S-adenosyl-L-methionine = H(+) + macrocin + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.102", "l": "\"Demethylmacrocin O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18334", "l": "ATP + oleandomycin => ADP + H(+) + oleandomycin 2'-O-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016762", "l": "xyloglucan:xyloglucosyl transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35824", "l": "5,6,7,8-tetrahydromethanopterin + NAD(+) => 7,8-dihydromethanopterin + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090562", "l": "protein-N(PI)-phosphohistidine-N,N'-diacetylchitobiose phosphotransferase system transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32264", "l": "4-aminobutanoate + pyruvate => L-alanine + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933528", "l": "Interaction of MEKK1 with TRAF6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31684", "l": "prosolanapyrone III => (-)-solanapyrone A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32826", "l": "phosphate(in) <=> phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-114284", "l": "Release of Cytochrome c from mitochondria (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42879", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> H(+) + N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33957", "l": "DIBOA beta-D-glucoside + H(+) + UDP => DIBOA + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102922", "l": "phenylpropanoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2186771", "l": "RNF111 binds SMAD7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626938", "l": "Beta-catenin binds SOX proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388833", "l": "Phosphorylation of CTLA-4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63159", "l": "H2O + N-docosanoyl-taurine <=> docosanoate + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39897", "l": "7-deoxyloganate + H(+) + UDP => 7-deoxyloganetate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340214", "l": "CYGB binds O2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853429", "l": "PHLDA1 binds AURKA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21829", "l": "H2O + nitrite + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + nitrate + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229283", "l": "LCNs bind lipids (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395517", "l": "NADPH transfers electrons to FDXR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19830", "l": "a primary alcohol + O2 => an aldehyde + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24405", "l": "(3S)-hydroxy-3-methylglutaryl-CoA => acetoacetate + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16740", "l": "H(+) + NADH + O2 + toluene <=> (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55175", "l": "2-oxoglutarate + hexanoyl-CoA + O2 <=> 2-hydroxyhexanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64582", "l": "diphosphate + nerylneryl diphosphate => (2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653886", "l": "B4GALT1 binds LALBA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005031", "l": "tumor necrosis factor-activated receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75172", "l": "Formation of RAD50:MRE11 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482857", "l": "CL transports from the ER to the IM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22846", "l": "glyceollin I + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65096", "l": "a 2-acylglycerol + hexadecanoyl-CoA = a 1-hexadecanoyl-2-acylglycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66094", "l": "H2O + kynurenate + L-phenylalanine => 3-phenylpyruvate + L-kynurenine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044667", "l": "(R)-carnitine:4-(trimethylammonio)butanoate antiporter activity"}, {"i": "RHEA:29427", "l": "(R)-carnitine(out) + 4-(trimethylamino)butanoate(in) = (R)-carnitine(in) + 4-(trimethylamino)butanoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964914", "l": "DHQ from DAHP dephosphorylation (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047069", "l": "7,8-dihydroxykynurenate 8,8a-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680443", "l": "ROCK1,2 bind ROCKi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5688786", "l": "ATXN3 binds RAD23 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64044", "l": "(13Z)-docosenoyl-CoA + sphing-4-enine = CoA + H(+) + N-(13Z-docosenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55765", "l": "1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O => 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39008", "l": "a cholesterol ester(in) => a cholesterol ester(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17615", "l": "H(+) + NADH + scyllo-inosose => NAD(+) + scyllo-inositol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29978", "l": "2'-deoxycytidine(in) + H(+)(in) <=> 2'-deoxycytidine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627775", "l": "Autophosphorylation of PAK1,2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097063", "l": "cadmium ion sensor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49072", "l": "dibenzothiophene + 2 FMNH2 + 2 O2 = dibenzothiophene 5,5-dioxide + 2 FMN + 2 H(+) + 2 H2O"}, {"i": "EC:1.14.14.21", "l": "\"Dibenzothiophene monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57869", "l": "(E)-4-coumaroyl-CoA + 2-oxoglutarate + O2 => (E)-2,4-dihydroxycinnamoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419645", "l": "Dimerization of LIMK1 by Hsp90 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170704", "l": "Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933527", "l": "Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64177", "l": "H2O + N-(9Z-octadecenoyl)-L-tryptophan => (9Z)-octadecenoate + L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18828", "l": "[(1->6)-alpha-D-glucosyl](n) + sucrose <=> [(1->6)-alpha-D-glucosyl](n+1) + D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003959", "l": "NADPH dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609740", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3B (GRIN3B) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60741", "l": "(S)-(-)-citronellal + H2O + NADP(+) => (S)-(-)-citronellate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25216", "l": "H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine <=> 2-N,3-O-bis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56362", "l": "13-dihydrocarminomycin + H2O + NADP(+) => 13-deoxycarminomycin + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28517", "l": "(R)-carnitine + ATP + CoA <=> (R)-carnitinyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15424", "l": "a long-chain fatty acid + ATP + CoA <=> a long-chain fatty acyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17237", "l": "ATP + FMN + H(+) = diphosphate + FAD"}, {"i": "EC:2.7.7.2", "l": "\"FAD synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50648", "l": "2-(2-methylsulfanyl)ethylmalate = 2-(2-methylsulfanyl)ethylmaleate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63658", "l": "1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48684", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine"}, {"i": "EC:3.5.1.130", "l": "\"[Amino group carrier protein]-lysine hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76373", "l": "N-hydroxylation of 4-aminobiphenyl (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-984733", "l": "Kinesin-3 is a dimer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.n1"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102671", "l": "6a-hydroxymaackiain-3-O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59811", "l": "L-tyrosine <=> D-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56425", "l": "H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => (9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32019", "l": "(2E,6E)-farnesyl diphosphate = beta-cubebene + diphosphate"}, {"i": "EC:4.2.3.128", "l": "\"Beta-cubebene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008110", "l": "Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24067", "l": "2 5-aminolevulinate <=> H(+) + 2 H2O + porphobilinogen"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626227", "l": "CP110 and CEP97 dissociate from the centriole (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22059", "l": "hexadecan-1-ol + NAD(+) <=> H(+) + hexadecanal + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111237", "l": "Formation of ADAR1 homodimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29660", "l": "O-acetyl-L-serine(in) => O-acetyl-L-serine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987120", "l": "JAK1 binds IFNLR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660622", "l": "IL1B gene is transcribed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6791109", "l": "GADD45A binds PCNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983138", "l": "Transport of MHC heterotrimer to ER exit site (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373746", "l": "SEMA4D interacts with CD45 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174446", "l": "Removal of remaining Flap from the C-strand (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665000", "l": "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050149", "l": "o-aminophenol oxidase activity"}, {"i": "RHEA:40963", "l": "4 2-aminophenol + 3 O2 = 2 2-aminophenoxazin-3-one + 6 H2O"}, {"i": "EC:1.10.3.4", "l": "\"o-aminophenol oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19699", "l": "11-cis-retinol + H(+) + hexadecanoate => 11-cis-retinyl hexadecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21671", "l": "ATP + H2O + sn-glycerol 3-phosphate(out) <=> ADP + H(+) + phosphate + sn-glycerol 3-phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601843", "l": "Defective CYP17A1 does not 17-hydroxylate PREG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62748", "l": "H2O + lovastatin = (S)-2-methylbutanoate + H(+) + monacolin J"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3785684", "l": "Fibronectin degradation by CTSG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17928", "l": "L-arabinofuranose + NAD(+) <=> H(+) + L-arabinono-1,4-lactone + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106151", "l": "CNBH domain intrinsic ligand binding"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015135", "l": "glucuronate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39719", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetracosanoate = 24-hydroxytetracosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3787997", "l": "Laminin-332 binds collagen type VII (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66511", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26167", "l": "AH2 + echinenone + O2 <=> 4'-hydroxyechinenone + A + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008963", "l": "phospho-N-acetylmuramoyl-pentapeptide-transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27936", "l": "glycine + glyoxylate => (3S)-3-hydroxy-D-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42847", "l": "6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH <=> 7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47819", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-diphosphate + NADPH + O2 <=> 9-ribosyl-trans-zeatin 5'-diphosphate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61771", "l": "rebaudioside A + UDP-alpha-D-glucose <=> H(+) + rebaudioside D + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940554", "l": "MMP2 cleaves OPTC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14937", "l": "all-trans-antheraxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = all-trans-violaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160935", "l": "SMURF1 ubiquitinates RHOA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44787", "l": "2-demethylmenaquinol-10 + S-adenosyl-L-methionine <=> H(+) + menaquinol-10 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194678", "l": "CYP51A1 demethylates LNSOL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53908", "l": "(2E)-butenoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-(2E)-butenoyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166753", "l": "Conversion of C4 into C4a and C4b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19431", "l": "[beta-adrenergic receptor]-phosphate + ADP + H(+) => [beta-adrenergic receptor] + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46004", "l": "2-methylpropanal + CoA + NAD(+) = 2-methylpropanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036402", "l": "proteasome-activating activity"}, {"i": "EC:5.6.1.5", "l": "\"Proteasome ATPase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25061", "l": "(E)-cinnamate + H(+) + NADH + O2 <=> (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30819", "l": "allantoin + H2O = allantoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35234", "l": "rifampicin(in) <=> rifampicin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791173", "l": "Expression of ATF3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41742", "l": "2 H(+) + N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine => adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050259", "l": "ribose 1-dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004690", "l": "cyclic nucleotide-dependent protein kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45169", "l": "2 (E)-sinapoyl-CoA + spermidine => 2 CoA + 2 H(+) + N(1),N(8)-bis[(E)-sinapoyl]-spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52379", "l": "(+)-sesamin monocatechol + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n <=> (+)-sesamin dicatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35053", "l": "N,N'-diacetylchitobiose(in) => N,N'-diacetylchitobiose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854303", "l": "TBC1D11 binds RAB6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21898", "l": "adenosylcob(III)inamide phosphate + ADP + H(+) + phosphate => (R)-1-aminopropan-2-yl phosphate + adenosylcob(III)yrate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39930", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212614", "l": "Glutamine transport from astrocytes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40861", "l": "(2E,9Z)-hexadecadienoyl-CoA + FADH2 => (9Z)-hexadecenoyl-CoA + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56313", "l": "3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O => 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847534", "l": "RAB43 hydrolyses GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38042", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44764", "l": "2-methoxy-6-all-trans-decaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22326", "l": "leukotriene B4 => H2O + leukotriene A4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64777", "l": "3-sulfanylpentan-1-ol-L-cysteine => 2-aminoprop-2-enoate + 3-sulfanyl-1-pentanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.75"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52536", "l": "adenosine + dGTP = AMP + dGDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56706", "l": "3-[(E)-2-isocyanovinyl]indole + 2 CO2 + H2O + succinate => (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0061650", "l": "ubiquitin-like protein conjugating enzyme activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605624", "l": "Beta-galactosidase hydrolyses GM1 to GM2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42255", "l": "H(+) + malonyl-[ACP] + pentanoyl-CoA <=> 3-oxoheptanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62196", "l": "2 [Fe(III)cytochrome c] + propan-2-ol = 2 [Fe(II)cytochrome c] + acetone + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52942", "l": "chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP => chenodeoxycholate + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686587", "l": "ABL1 phosphorylates RAD52 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18254", "l": "(S)-malate + NADP(+) => CO2 + NADPH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14797", "l": "2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34753", "l": "ADP + H(+) + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate => ATP + N-acyl-15-methylhexadecasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44396", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-heptadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47919", "l": "ATP + N-hexanoyl-(4R)-hydroxysphinganine <=> ADP + H(+) + N-hexanoyl-(4R)-hydroxysphinganine-1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49079", "l": "dibenzothiophene + FMNH2 + O2 <=> dibenzothiophene 5-oxide + FMN + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47634", "l": "5-guanidino-2-oxopentanoate + H(+) + NADH + NH4(+) => H2O + L-arginine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20657", "l": "4-chlorophenylacetonitrile + 2 H2O = 4-chlorophenylacetate + NH4(+)"}, {"i": "EC:3.5.5.5", "l": "\"Arylacetonitrilase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913360", "l": "GM-CSF receptor alpha subunit binds GM-CSF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17897", "l": "A + ethylbenzene + H2O = (S)-1-phenylethanol + AH2"}, {"i": "EC:1.17.99.2", "l": "\"Ethylbenzene hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788623", "l": "p-Y-STATs translocate to nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65659", "l": "A + cholest-1,4-dien-3-one + H2O <=> 25-hydroxycholest-1,4-dien-3-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73797", "l": "FAICAR => IMP + H2O (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14687", "l": "AH2 + an aldehyde => A + a primary alcohol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64972", "l": "dUDP + H2O = dUMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40460", "l": "(2S)-pristanoyl-CoA + O2 => (2E)-pristenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43341", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] => [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25358", "l": "2-hydroxyphytanoyl-CoA <=> 2,6,10,14-tetramethylpentadecanal + formyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54878", "l": "(3S)-3-isopropenyl-6-oxoheptanoate + H(+) => (4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429714", "l": "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0004532", "l": "exoribonuclease activity"}, {"i": "REACT:R-HSA-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47074", "l": "eicosanoate + glycerol + H(+) => 1-eicosanoylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41273", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032001", "l": "1,4-alpha-glucan 6-alpha-glucosyltransferase activity"}, {"i": "MetaCyc:2.4.1.24-RXN"}, {"i": "EC:2.4.1.24", "l": "\"1,4-alpha-glucan 6-alpha-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2509831", "l": "ITPA hydrolyses XTP to XMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354097", "l": "Activation of Talin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30686", "l": "H2O + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N-acetyl-D-mannosamine + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1454916", "l": "The ABCC family mediates organic anion transport (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194678", "l": "CYP51A1 demethylates LNSOL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74258", "l": "XDH oxidizes xanthine to form urate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.n2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.6.-", "l": "\"With a nitrogenous group as acceptor\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005052", "l": "peroxisome matrix targeting signal-1 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39077", "l": "(3S)-hydroxydodecanedioyl-CoA => (2E)-dodecenedioyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944263", "l": "Association of procollagen type II (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879907", "l": "Tyrosine kinases phosphorylate the receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2197690", "l": "Detachment of WASP/WAVE (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53218", "l": "16alpha,17alpha-dihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25517", "l": "an acyl-CoA + tropine => CoA + H(+) + O-acyltropine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54073", "l": "(2E)-geranyl diphosphate => beta-thujene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43516", "l": "2-carboxy-5-formylfuran + H2O = 2-carboxy-5-(dihydroxymethyl)furan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28683", "l": "L-aspartate + ubiquinone-8 = iminosuccinate + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012654", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32267", "l": "4-aminobutanoate + glyoxylate = glycine + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209815", "l": "Tyrosine is monoiodinated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15137", "l": "galactitol 1-phosphate + NAD(+) = H(+) + keto-L-tagatose 6-phosphate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15795", "l": "biliverdin IXalpha + H(+) + NADPH => bilirubin IXalpha + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48394", "l": "GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41362", "l": "H(+) + hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210920", "l": "NEUROG3-dependent synthesis of NEUROD1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63499", "l": "4-nitrobenzaldehyde + H(+) + NADPH <=> 4-nitrobenzyl alcohol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008776", "l": "acetate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218847", "l": "PAK2 binds NCK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15484", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24097", "l": "isoorientin + S-adenosyl-L-methionine => H(+) + isoscoparin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11305", "l": "(S)-ureidoglycolate => glyoxylate + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52777", "l": "2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => camalexin + CO2 + 2 H(+) + 4 H2O + hydrogen cyanide + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951644", "l": "Release of mature NEDD8 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54190", "l": "acetate + L-phenylalanine => H2O + N-acetyl-L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25425", "l": "diphosphate + GMP => 5-phospho-alpha-D-ribose 1-diphosphate + guanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16591", "l": "3-dehydro-alpha-D-glucosyl beta-D-fructofuranoside + AH2 => A + sucrose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.148", "l": "\"Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77589", "l": "Recognition of AAUAAA sequence by CPSF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174445", "l": "RPA binds to the Flap on the C-strand (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30264", "l": "H2O2 + 2 L-ascorbate => 2 H2O + 2 monodehydro-L-ascorbate radical"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55433", "l": "11-hydroxyferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => carnosate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65849", "l": "A + a 3-oxo-Delta(1)-steroid + H2O => a steroid 1,3-dione + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856223", "l": "B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0097625", "l": "low-affinity basic amino acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0015925", "l": "galactosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41027", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + tetradecanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-tetradecanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168136", "l": "NOTCH3 binds DLL4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5334794", "l": "FABPs bind LCFAs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33325", "l": "a 1-acyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28915", "l": "4-aminobutanoate(in) + H(+)(in) = 4-aminobutanoate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43190", "l": "H(+) + N(3)-methyluridine(2634) in 25S rRNA + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2634) in 25S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49639", "l": "H2O + methylglyoxal + O2 <=> H(+) + H2O2 + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944215", "l": "Association of procollagen type XX (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17434", "l": "A + choline => AH2 + betaine aldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174438", "l": "Formation of the Flap Intermediate on the C-strand (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047183", "l": "anthocyanin 5-aromatic acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051745", "l": "4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390886", "l": "HRH4 binds Hist (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25072", "l": "3-hydroxybenzoyl-CoA + AMP + diphosphate => 3-hydroxybenzoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2514831", "l": "Fibrillin-1 degradation by MMP14 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45601", "l": "D-galactaro-1,4-lactone => 5-dehydro-4-deoxy-D-glucarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58347", "l": "beta-D-glucosyl-(1->3)-O-lithocholate + H2O <=> D-glucose + lithocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2032781", "l": "WWTR1 (TAZ) binds TEAD (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22150", "l": "a plastoquinone + 4 H(+)(out) + 2 reduced [plastocyanin] => a plastoquinol + 2 H(+)(in) + 2 oxidized [plastocyanin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53974", "l": "(8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694435", "l": "MIA2 and MIA3 load procollagen VII into COPII vesicles (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004920", "l": "interleukin-10 receptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004575", "l": "sucrose alpha-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951499", "l": "Loading of antigenic peptides on to class I MHC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635102", "l": "GPR161 is internalized (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352872", "l": "fructose 6-phosphate <=> glucose 6-phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29736", "l": "butane-1-sulfonate + FMNH2 + O2 => butanal + FMN + 2 H(+) + H2O + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102174", "l": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24752", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + primary fluorescent chlorophyll catabolite = 3 H(+) + red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.3.7.12", "l": "\"Red chlorophyll catabolite reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38500", "l": "a triacyl-sn-glycerol + H2O => a 2,3-diacyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38333", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol => 1,3-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0008236", "l": "serine-type peptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333607", "l": "GSSeH combines with bGalNAc derivative to form GSSebGalNac (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050386", "l": "ureidosuccinase activity"}, {"i": "MetaCyc:UREIDOSUCCINASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33718", "l": "4-hydroxyeicosasphinganine 1-phosphate <=> 2-hydroxyoctadecanal + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937075", "l": "Phosphorylated TAK1 leaves activated TLR receptor complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205649", "l": "p62 links damaged mitochondria to LC3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693783", "l": "NAALADases hydrolyse NAAG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802910", "l": "Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24580", "l": "D-sorbitol 6-phosphate + H2O = D-sorbitol + phosphate"}, {"i": "EC:3.1.3.50", "l": "\"Sorbitol-6-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13373", "l": "H2O + L-mimosine = 3-hydroxy-4H-pyrid-4-one + L-serine"}, {"i": "EC:3.5.1.61", "l": "\"Mimosinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015250", "l": "water channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641229", "l": "TLE oligomerizes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34839", "l": "4 H(+) + 5 malonyl-CoA = 5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO2 + 5 CoA + H2O"}, {"i": "EC:2.3.1.216", "l": "\"5,7-dihydroxy-2-methylchromone synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419277", "l": "GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2473594", "l": "Collagen type II degradation by MMP15 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41693", "l": "1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028598", "l": "Phosphorylation of YAP by LATS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18508", "l": "L-lysine + NAD(+) <=> Delta(1)-piperideine-2-carboxylate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41045", "l": "1-O-hexadecyl-2-acetyl-3-octanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030881", "l": "beta-2-microglobulin binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018710", "l": "acetone carboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54810", "l": "H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate + NADP(+) => H(+) + L-isoleucine-(+)-7-isojasmonate + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52269", "l": "3-(aminomethyl)indole + S-adenosyl-L-methionine => (1H-indol-3-yl)-N-methylmethanamine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099507", "l": "ligand-gated ion channel activity involved in regulation of presynaptic membrane potential"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49612", "l": "(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH"}, {"i": "EC:1.1.1.399", "l": "\"2-oxoglutarate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111915", "l": "CAMK4 autophosphorylates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12431", "l": "2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH <=> benzene-1,2,4-triol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000827", "l": "inositol-1,3,4,5,6-pentakisphosphate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9035484", "l": "CysS248-MPST:TXN2 dissociates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938853", "l": "CDK6 binds RUNX1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1253343", "l": "WWOX binds ERBB4s80 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004658", "l": "propionyl-CoA carboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14503", "l": "2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+) => H2O + L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389381", "l": "Gads binds CD28 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69299", "l": "CDT1 binds geminin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029272", "l": "Release of PLCG from FCGR (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65190", "l": "berkeleydione + CO2 + H2O + succinate => 2-oxoglutarate + berkeleyone B + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40228", "l": "3'-phosphoadenylyl sulfate + desulfo-A47934 => A47934 + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44613", "l": "3-(all-trans-decaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-decaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396234", "l": "Collagen type VII binds laminin-322 and collagen IV (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432897", "l": "ILK interacts with beta-1 integrin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58669", "l": "3-deoxyfructose + NADP(+) => 3-deoxyglucosone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32808", "l": "thiosulfate(in) => thiosulfate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202713", "l": "CD84 homodimerises (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58438", "l": "4-methylpentanal + H(+) + NADPH => 4-methylpentan-1-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0070818", "l": "protoporphyrinogen oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008927", "l": "mannonate dehydratase activity"}, {"i": "RHEA:20097", "l": "D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O"}, {"i": "EC:4.2.1.8", "l": "\"Mannonate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56628", "l": "5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H2O = chloride + 2 H(+) + maleylacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047538", "l": "2-carboxy-D-arabinitol-1-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51167", "l": "cytidine(61) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(61) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54116", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + pseudolaratriene"}, {"i": "EC:4.2.3.180", "l": "\"Pseudolaratriene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376122", "l": "DSCAM/DSCAML1 homodimerization (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-429036", "l": "SLC2A9 transports Fru, Glc, urate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10952", "l": "(E)-sinapoyl-CoA + hydroxymalonate = (E)-sinapoyltartronate + CoA"}, {"i": "EC:2.3.1.106", "l": "\"Tartronate O-hydroxycinnamoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0046870", "l": "cadmium ion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626223", "l": "C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51097", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018731", "l": "1-oxa-2-oxocycloheptane lactonase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038131", "l": "neuregulin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21882", "l": "2 CO2 + H2O2 => 2 H(+) + O2 + oxalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799409", "l": "HIPK2 phosphorylates TP53 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44304", "l": "a 1-acyl-sn-glycero-3-phosphate + dodecanoyl-CoA = a 1-acyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862184", "l": "USP48 cleaves polyubiquitin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26290", "l": "2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine => 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38102", "l": "a ribonucleoside 5'-triphosphate + phytyl phosphate <=> a ribonucleoside 5'-diphosphate + phytyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53276", "l": "17beta-hydroxy-3,19-dioxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] = 17beta-hydroxy-3-oxo-19-nor-5alpha-androst-1-ene + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22221", "l": "ent-copalyl diphosphate => diphosphate + ent-kaur-16-ene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987214", "l": "p-STAT3 dimerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928624", "l": "EPHBs bind EFNBs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35751", "l": "ATP + kanosamine = ADP + D-kanosamine 6-phosphate + H(+)"}, {"i": "EC:2.7.1.179", "l": "\"Kanosamine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14024", "l": "AH2 + ecdysone + O2 <=> 20-hydroxyecdysone + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45885", "l": "12-methyloctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(11-methylheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32054", "l": "H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate <=> adenosine 5'-tetraphosphate + AMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31762", "l": "dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine <=> dTDP-alpha-D-desosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021068", "l": "PalmS-ESRs bind CAVs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65857", "l": "A + a 1-hydroxy-3-oxo steroid => a steroid 1,3-dione + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11014", "l": "L-tryptophan + NH4(+) => H2O + L-tryptophanamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936851", "l": "AHRR binds ARNT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46381", "l": "7alpha-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62127", "l": "a 2'-deoxyribonucleoside 5'-phosphate + GTP <=> a 2'-deoxyribonucleoside 5'-diphosphate + GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202212", "l": "Recruitment of PLC-gamma1 to LAT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40617", "l": "2,3-didecanoyl-sn-glycerol + decanoate + H(+) => H2O + tridecanoylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421835", "l": "trans-Golgi Network Vesicle Scission (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42384", "l": "4,4'-diaponeurosporenal + H2O + NAD(+) = 4,4'-diaponeurosporenoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33508", "l": "sphing-4-enine 1-phosphate => (2E)-hexadecenal + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35388", "l": "precorrin-7 + S-adenosyl-L-methionine => 2 H(+) + precorrin-8X + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005133", "l": "interferon-gamma receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388811", "l": "CD28 homodimer binds B7-1 homodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37915", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798748", "l": "Exocytosis of secretory granule lumen proteins (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51871", "l": "dimethylallyl diphosphate + umbelliferone <=> demethylsuberosin + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35699", "l": "(S)-versiconol + NADP(+) = (2S-3S)-versiconal hemiacetal + H(+) + NADPH"}, {"i": "EC:1.1.1.353", "l": "\"Versiconal hemiacetal acetate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31527", "l": "N(omega)-hydroxy-L-arginine = (S)-1-pyrroline-5-carboxylate + guanidine + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444572", "l": "Zinc is an agonist of GPR39 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508513", "l": "PTK2B binds JAK3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090447", "l": "glycerol-3-phosphate 2-O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809663", "l": "Formation of hair keratin fibres (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351871", "l": "Caspase-mediated cleavage of Z0-2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12860", "l": "(2S,3S)-3-methyl-L-aspartate <=> L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22852", "l": "L-serine + pyruvate = 3-hydroxypyruvate + L-alanine"}, {"i": "EC:2.6.1.51", "l": "\"Serine--pyruvate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61079", "l": "(-)-minovincinine + acetyl-CoA <=> (-)-echitovenine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47662", "l": "CoA + H(+) + N-acetyl-L-methionine sulfoximine => acetyl-CoA + L-methionine sulfoximine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56083", "l": "[Rab1 protein]-L-serine + CDP-choline <=> [Rab1 protein]-O-phosphocholine-L-serine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008894", "l": "guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5681987", "l": "LC3 is cleaved by ATG4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21719", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + (S)-mandelate + O2 <=> (6R)-L-erythro-6,7-dihydrobiopterin + (S)-4-hydroxymandelate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36835", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51123", "l": "(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 AH2 <=> (8S,15S)-dihydroxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1462039", "l": "Pro-HNP1-4 are cleaved to biologically active defensin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.34"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990931", "l": "mRNA N6-methyladenosine dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5576895", "l": "SCNAs:SNCBs transport Na+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-482772", "l": "Release of platelet cytosolic components (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034480", "l": "phosphatidylcholine phospholipase C activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036428", "l": "adenosylcobinamide kinase (GTP-specific) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48476", "l": "ganglioside GT1a (d18:1(4E)) + H2O = ganglioside GD1a (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34644", "l": "2 S-adenosyl-L-methionine + squalene => 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + 2 H(+) + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50507", "l": "acetyl-CoA + N-terminal L-seryl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050282", "l": "serine 2-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694341", "l": "Spike protein gets palmitoylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799097", "l": "ATM phosphorylates ZNF420 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36402", "l": "5alpha-cholest-8-en-3beta-ol + NADP(+) <=> 5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22919", "l": "4'-hydroxyacetophenone + H(+) + NADPH + O2 <=> 4-acetoxyphenol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24946", "l": "1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NADP(+) <=> 4-hydroxy-L-glutamate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31608", "l": "rhodopin => all-trans-lycopene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23251", "l": "myo-inositol + S-adenosyl-L-methionine <=> 1D-4-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.161", "l": "\"Oligosaccharide 4-alpha-D-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607734", "l": "PKC-delta translocates to plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030790", "l": "chlorophenol O-methyltransferase activity"}, {"i": "RHEA:18909", "l": "2,4,6-trichlorophenol + S-adenosyl-L-methionine = 2,4,6-trichloroanisole + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.136", "l": "\"Chlorophenol O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480520", "l": "Expression of SALL4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46945", "l": "(S)-2-amino-6-oxohexanoate + holo-[LYS2 peptidyl-carrier protein] + NADP(+) => H(+) + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50233", "l": "8 H(+) + heme b + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => biliverdin IXalpha + CO + Fe(2+) + 3 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690023", "l": "NUBPL binds 4Fe-4S (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.n3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2090079", "l": "GLB1 hydrolyses linker chain(2) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031895", "l": "V1B vasopressin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16853", "l": "N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114670", "l": "GPIb-IX-V binds to vWF:Collagen complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44653", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61629", "l": "5-aminopentanal => 1-piperideine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63500", "l": "H(+) + NADPH + S-nitrosoglutathione = NADP(+) + sulfinamide glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53146", "l": "H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5674385", "l": "p-T,Y MAPKs dimerize (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202110", "l": "eNOS:Caveolin-1 complex binds to CaM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047620", "l": "acylglycerol kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668545", "l": "NIK autophosphorylates on T559 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033472", "l": "FGFR2c mutants bind an expanded range of ligands (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55528", "l": "H(+) + H2O + L-tyrosine + O2 = (4-hydroxyphenyl)acetaldehyde + CO2 + H2O2 + NH4(+)"}, {"i": "EC:4.1.1.108", "l": "\"4-hydroxyphenylacetaldehyde synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33086", "l": "dehypoxanthine futalosine + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428750", "l": "Gq activation by TP receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67117", "l": "N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110360", "l": "Recruitment of POLB to the AP site (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444572", "l": "Zinc is an agonist of GPR39 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50860", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791130", "l": "Expression of CTDSP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29586", "l": "guanosine(in) + H(+)(out) <=> guanosine(out) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034556", "l": "nitrobenzoate nitroreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14313", "l": "2-iodophenol + S-adenosyl-L-methionine = 1-iodo-2-methoxybenzene + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.26", "l": "\"Iodophenol O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49187", "l": "chlorophyllide a + H(+) + H2O <=> 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + CO2 + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40090", "l": "22-hydroxydocosanoate + NAD(+) <=> 22-oxodocosanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013006", "l": "RHOA:GTP translocates to the ER membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53637", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65540", "l": "ganglioside GM3 + H2O = an N-acyl-sphingoid base + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163595", "l": "2-acylglycerol + H2O -> glycerol + fatty acid (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37114", "l": "(15Z)-tetracosenoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-141423", "l": "Binding of the MCC complex to the APC/C complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428534", "l": "Recruitment of Profilin by Ena/VASP proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696146", "l": "AOC2 deaminates TYR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944254", "l": "Association of procollagen type XXVI (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46199", "l": "O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] <=> 7alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44326", "l": "butanoate + glycerol + H(+) => 1-butyrylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14867", "l": "H(+) + N-methyltyramine + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + tyramine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6790038", "l": "Expression of HSP90B1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018760", "l": "thiocyanate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16118", "l": "acetoacetate + ATP + CoA => acetoacetyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205136", "l": "GTP-bound RAC contributes to JNK activation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57376", "l": "(S)-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-1-hydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.166", "l": "\"(S)-N-methylcanadine 1-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56925", "l": "ATP + L-threonyl-[Goodpasture antigen-binding protein] => ADP + H(+) + O-phospho-L-threonyl-[Goodpasture antigen-binding protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23693", "l": "(R)-malate => H2O + maleate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250616", "l": "botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50187", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 <=> N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372697", "l": "Crk binding to p130cas (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2995334", "l": "COX15 transforms heme O to heme A (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68954", "l": "Mcm2-7 is phosphorylated by DDK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30831", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose = UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-hex-4-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395517", "l": "NADPH transfers electrons to FDXR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51259", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate + O2 <=> (9S,16S)-dihydroperoxy-(10E,12Z,14E)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983259", "l": "Kinesins move along microtubules consuming ATP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004042", "l": "acetyl-CoA:L-glutamate N-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62848", "l": "GDP-beta-L-fucose + methyl 8-{[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45906", "l": "dTDP + epivancomycin + H(+) => devancoaminyl-vancomycin + dTDP-beta-L-vancosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62807", "l": "2 7-demethylsiderin + NADPH + O2 <=> desertorin A + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58652", "l": "rifamycin SV ortho-naphthoquinone carboxamide = rifamycin SV para-naphthoquinone carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425861", "l": "Activation of Protein Kinase C novel isoforms (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046934", "l": "phosphatidylinositol-4,5-bisphosphate 3-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433488", "l": "Phosphorylation of SHP2 by SFKs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66809", "l": "5-aminopentanoate + acetyl-CoA + 17 H(+) + 7 malonyl-CoA + 11 NADPH => 7 CO2 + 8 CoA + 6 H2O + 11 NADP(+) + wortmanamide A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62498", "l": "diphosphate + L-arginyl-AMP => ATP + H(+) + L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46852", "l": "5alpha-cholest-8-en-3-one + H(+) + NADPH = 5alpha-cholest-8-en-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24504", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)"}, {"i": "EC:1.13.11.54", "l": "\"Acireductone dioxygenase (Fe(2+)-requiring)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27970", "l": "alpha-maltotriose + H2O = alpha-D-glucose + beta-maltose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31456", "l": "NAD(+) + reduced riboflavin => 2 H(+) + NADH + riboflavin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19469", "l": "NADH + 2 nitric oxide + 2 O2 = H(+) + NAD(+) + 2 nitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52811", "l": "adenosine in U6 snRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64389", "l": "4 A + sn-3-O-phytanylglycerol 1-phosphate => 4 AH2 + sn-3-O-(geranylgeranyl)glycerol 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940554", "l": "MMP2 cleaves OPTC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37936", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52801", "l": "acetoacetyl-CoA + ATP + L-isoleucine => AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23229", "l": "L-lysine + NADPH + O2 => H2O + N(6)-hydroxy-L-lysine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39544", "l": "3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22483", "l": "4-(hydroxyamino)quinoline N-oxide + H2O + 2 NAD(+) <=> 4-nitroquinoline N-oxide + 2 H(+) + 2 NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015196", "l": "L-tryptophan transmembrane transporter activity"}, {"i": "REACT:R-HSA-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17310", "l": "a phenyl acetate + H2O => a phenol + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34065", "l": "2'-deamino-2'-hydroxyparomamine + H(+) + UDP => 2-deoxystreptamine + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73797", "l": "FAICAR => IMP + H2O (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047628", "l": "ADP-thymidine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9734730", "l": "ORC1 translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191656", "l": "Closure of gap junction (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21821", "l": "L-homocysteine + S-adenosyl-L-methionine => H(+) + L-methionine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54417", "l": "5alpha-campestan-3-one + NADP(+) => campest-4-en-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399712", "l": "Activation of Ca permeable AMPA receptors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55399", "l": "(R)-carnitine + H(+) + NADH + O2 <=> (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44450", "l": "a 3-oxoacyl-[ACP] + CO2 + CoA => an acyl-CoA + H(+) + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11990", "l": "1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine => 1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "66.327668440521322", "identifiers": [{"i": "GO:0016706", "l": "2-oxoglutarate-dependent dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47671", "l": "H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446322", "l": "PARVA associates with Paxillin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3785768", "l": "MRN complex binds DNA double strand breaks (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-205136", "l": "GTP-bound RAC contributes to JNK activation (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56141", "l": "H2O + S-adenosyl-L-methionine => adenosine + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52905", "l": "15,17(3)-seco-F430-17(3)-acid + ATP => ADP + coenzyme F430 + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13483", "l": "AMP + diphosphate + L-methionyl-tRNA(Met) => ATP + L-methionine + tRNA(Met)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190065", "l": "Activated TrkA receptor internalizes to endosomes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27688", "l": "ADP + GTP => ATP + GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64993", "l": "acetyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-acetyl-4'-phosphopantetheine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15282", "l": "5alpha-cholest-7-en-3beta-ol => 5alpha-cholest-8-en-3beta-ol"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0042805", "l": "actinin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32067", "l": "8-oxoguanine + H(+) + H2O = NH4(+) + urate"}, {"i": "EC:3.5.4.32", "l": "\"8-oxoguanine deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229343", "l": "AXIN is phosphorylated in the destruction complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601897", "l": "MeR-PIWIL4:2'-O-methyl-piRNA:TDRD9:MAEL:TDRKH dissociates and MeR-PIWIL4:2'-O-methylpiRNA, TDRD9, MAEL translocate from cytosol to nucleus in an unknown association and order of events (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40799", "l": "2-methylpropanoyl-CoA + H2O = 2-methylpropanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17970", "l": "ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198669", "l": "p38MAPK phosphorylates MSK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0086080", "l": "protein binding involved in heterotypic cell-cell adhesion"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31837", "l": "dTDP-3-dehydro-6-deoxy-alpha-D-galactose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26480", "l": "a 2-demethylmenaquinol + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610745", "l": "SCF(beta-TrCP) ubiquitinates p-GLI2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647977", "l": "ICMT methylates S-Farn RAS proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46278", "l": "(S)-lactate + CO2 => (S)-malate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21317", "l": "H2O + phorbol 12,13-dibutanoate => butanoate + H(+) + phorbol 13-butanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27930", "l": "(R)-4-phosphopantoate + ATP + beta-alanine = (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)"}, {"i": "EC:6.3.2.36", "l": "\"4-phosphopantoate--beta-alanine ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48097", "l": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine => 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37408", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11267", "l": "H(+) + NADH + O2 <=> H2O2 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201521", "l": "ALK autophosphorylation downstream of PTN and MDK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13634", "l": "ATP + L-glutamate + putrescine => ADP + gamma-L-glutamylputrescine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18599", "l": "NADH + 2 oxidized [rubredoxin] => H(+) + NAD(+) + 2 reduced [rubredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2660822", "l": "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937856", "l": "p-Y-YAP1 translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0009020", "l": "tRNA (guanosine-2'-O-)-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36923", "l": "(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420233", "l": "VIP receptors bind VIP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0016889", "l": "endodeoxyribonuclease activity, producing 3'-phosphomonoesters"}, {"i": "EC:3.1.22.-", "l": "\"Endodeoxyribonucleases producing other than 5'-phosphomonoesters\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39721", "l": "24-hydroxytetracosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetracosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18192", "l": "[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose <=> [(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58576", "l": "dihydroprecondylocarpine acetate + NADP(+) = H(+) + NADPH + precondylocarpine acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75079", "l": "Formation of AT-AC C complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64029", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8)-citryl-spermidine => H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35129", "l": "L-alanyl-D-glutamate(in) => L-alanyl-D-glutamate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62896", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc + GDP-beta-L-fucose = alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17359", "l": "H2O2 + R'C(R)S-S(R)CR' => O2 + 2 R'C(R)SH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102169", "l": "pyocyanin hydroxylase activity"}, {"i": "RHEA:48976", "l": "5-methyl-phenazine-1-carboxylate + 2 H(+) + NADH + O2 = CO2 + H2O + NAD(+) + pyocyanin"}, {"i": "RHEA:53868", "l": "2 H(+) + NADH + O2 + phenazine-1-carboxylate = 1-hydroxyphenazine + CO2 + H2O + NAD(+)"}, {"i": "MetaCyc:RXN-11898"}, {"i": "EC:1.14.13.218", "l": "\"5-methylphenazine-1-carboxylate 1-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607733", "l": "BCL10 binds CARD9 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805640", "l": "AKT phosphorylates KAT6A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.5", "l": "\"Dipeptidyl-peptidase IV\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033130", "l": "acetylcholine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9612501", "l": "SGK phosphorylates CREB1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3341294", "l": "Superoxide reduces cytochrome c (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019992", "l": "diacylglycerol binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865182", "l": "OTUD7A hydrolyses K11diUb (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58143", "l": "acetyl-AMP + cytidine(34) in elongator tRNA(Met) <=> AMP + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16503", "l": "H(+) + myo-inositol + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phospho-1D-myo-inositol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080096", "l": "phosphatidate-sterol O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-901047", "l": "Binding of ERp57 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030751", "l": "licodione 2'-O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296045", "l": "Activation of Potassium transport channels (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0031717", "l": "cannabinoid receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638209", "l": "Defective SLC2A9 does not transport Fru, Glc, urate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29158", "l": "2 H(+)(out) + nitrite(out) + 3 ubiquinol-8(in) <=> 2 H2O(out) + NH4(+)(out) + 3 ubiquinone-8(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60253", "l": "(S)-methylmalonyl-CoA + NADP(+) => acryloyl-CoA + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005096", "l": "GTPase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14915", "l": "adenosine + dTMP => AMP + thymidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29203", "l": "dimethyl sulfoxide + menaquinol-8 = dimethyl sulfide + H2O + menaquinone-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390595", "l": "Calcium Binds Troponin-C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296127", "l": "Activation of voltage gated Potassium channels (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618107", "l": "ATP binding to HSP90 triggers conformation change (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70982", "l": "Fumarate + H2O <=> (S)-Malate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22253", "l": "globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => globoside Gb4Cer (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201521", "l": "ALK autophosphorylation downstream of PTN and MDK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429683", "l": "CERT:ceramide [ER] => ceramide [Golgi] + CERT [ER] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202245", "l": "Phosphorylation of TBSMs in LAT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.-", "l": "\"Carbon-sulfur lyases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351871", "l": "Caspase-mediated cleavage of Z0-2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19384", "l": "(S)-oxalosuccinate + H(+) <=> 2-oxoglutarate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10538", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate => 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218642", "l": "PTK2 autophosphorylates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35742", "l": "cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin] <=> 4-methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53947", "l": "2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+) <=> (2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2129357", "l": "Fibrillin C-terminal processing (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25641", "l": "(1R,4S)-menthone + NADP(+) = (R)-pulegone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73800", "l": "SAICAR => AICAR + Fumarate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16995", "l": "6 [Fe(II)cytochrome c] + 7 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] => 6 [Fe(III)cytochrome c] + 3 H2O + S-disulfanyl-L-cysteinyl-[SoxY protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49638", "l": "H(+) + H2O2 + pyruvate => H2O + methylglyoxal + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141159", "l": "TNF-mediated dimerization of procaspase-8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51639", "l": "a quinone + H2O + selenite <=> a quinol + selenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51803", "l": "deoxyadlupulone + dimethylallyl diphosphate <=> adlupulone + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098627", "l": "protein arginine phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018826", "l": "RHOT2 hydrolyzes GTP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655483", "l": "USP1 autocleavage (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607734", "l": "PKC-delta translocates to plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58385", "l": "NADP(+) + octan-1-ol => H(+) + NADPH + octanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37999", "l": "2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + S-adenosyl-L-methionine = H(+) + plastoquinol-9 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57119", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444433", "l": "Cho transports from the extracellular space to the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15008", "l": "2-oxoglutarate + gibberellin A1 + O2 <=> CO2 + gibberellin A8 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4225086", "l": "Defective mitochondrial BTD does not hydrolyse BCTN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56750", "l": "an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27466", "l": "ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) => ADP-D-glycero-beta-D-manno-heptose + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14823", "l": "L-ribulose => L-arabinose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871373", "l": "BMX phosphorylates RUFY1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109858", "l": "MAP2K2 binds MAPK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0052840", "l": "inositol diphosphate tetrakisphosphate diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202709", "l": "JAM2 dimerises (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955893", "l": "SOCS4 gene expression is inhibited by RUNX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114256", "l": "CYCS:APAF1 binds procaspase-9 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2471621", "l": "Endostatin degradation by cathepsins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59568", "l": "4-aminobutanoate + ATP + L-histidine = ADP + H(+) + L-homocarnosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27388", "l": "H2O + maleamate <=> maleate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43644", "l": "H(+) + malonyl-[ACP] + tetradecanoyl-CoA = 3-oxohexadecanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132260", "l": "Complement factor I inactivates surface-bound C3b (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41626", "l": "H(+) + propanoyl-CoA + sulfite => 3-sulfinopropanoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20724", "l": "a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O"}, {"i": "EC:4.2.1.17", "l": "\"Enoyl-CoA hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62673", "l": "a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine => an N(6)-methyl-2'-O-methyladenosine in U2 snRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.8", "l": "\"Endo-1,4-beta-xylanase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005146", "l": "leukemia inhibitory factor receptor binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005528", "l": "FK506 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30714", "l": "(S)-linalool <=> beta-myrcene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16585", "l": "[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]"}, {"i": "EC:2.8.1.8", "l": "\"Lipoyl synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22573", "l": "A + H2O + N-methyl-L-glutamate => AH2 + formaldehyde + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014294", "l": "RAC2 binds effectors at the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37596", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209754", "l": "Photolytic cleavage and thermal isomerization of 7-dehydroCHOL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322434", "l": "XIAP dissociates from ub-TLE (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450494", "l": "HuR binds mRNAs in the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42976", "l": "L-tryptophan = 2-aminoprop-2-enoate + indole"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5444511", "l": "Formation of MSH2:MSH3 Complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046028", "l": "electron transporter, transferring electrons from cytochrome b6/f complex of photosystem II activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31352", "l": "lupan-3beta,20-diol => (S)-2,3-epoxysqualene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106250", "l": "DNA-binding transcription repressor activity, RNA polymerase III-specific"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507870", "l": "Aquaporins passively transport water out of cells (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21926", "l": "2,3-dioxo-L-gulonate + H(+) + NADH => 3-dehydro-L-gulonate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159761", "l": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58028", "l": "5 (S)-methylmalonyl-CoA + a medium-chain fatty acyl-CoA + 32 H(+) + 5 malonyl-CoA + 22 NADPH = a mycoketide-CoA + 10 CO2 + 10 CoA + 11 H2O + 22 NADP(+)"}, {"i": "EC:2.3.1.295", "l": "\"Mycoketide-CoA synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2106614", "l": "Duplex miRNA is loaded into Argonaute (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047962", "l": "glycine N-benzoyltransferase activity"}, {"i": "RHEA:18493", "l": "benzoyl-CoA + glycine = CoA + H(+) + N-benzoylglycine"}, {"i": "EC:2.3.1.71", "l": "\"Glycine N-benzoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158118", "l": "factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49492", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate = 2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + 2-oxoglutarate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53856", "l": "NADP(+) + ursocholate = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769401", "l": "DKK and KRM bind LRP5/6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606312", "l": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21138", "l": "CoA + O-acetyl-(R)-carnitine => (R)-carnitine + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798748", "l": "Exocytosis of secretory granule lumen proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52479", "l": "estrone + UDP-alpha-D-glucuronate <=> estrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41796", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404142", "l": "atROL binds RBP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56003", "l": "H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] <=> beta-D-glucose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-167427", "l": "Opioid dissociates from MOR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33477", "l": "a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10811", "l": "(S)-2-hydroxypropylphosphonate + H2O2 <=> (1R,2S)-epoxypropylphosphonate + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25763", "l": "(2R,3S)-3-methylmalate + NAD(+) = 3-carboxy-2-oxobutanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52143", "l": "(DNA)-3'-diphospho-5'-guanosine + H2O <=> (DNA)-3'-phosphate + GMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14728", "l": "2 ATP + 2 cob(II)inamide + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)inamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55249", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4551683", "l": "SUMOylation of TOPORS with SUMO1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42786", "l": "2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine => adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5444523", "l": "Formation of MSH1:PMS2 Complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59902", "l": "CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate => 2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57044", "l": "D-apionate + NAD(+) = 3-oxoisoapionate + H(+) + NADH"}, {"i": "EC:1.1.1.421", "l": "\"D-apionate oxidoisomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25174", "l": "H2O + N(omega)-methyl-L-arginine => L-citrulline + methylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19675", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) => 1,2,3-trihydroxybenzene + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024586", "l": "AT-RvD1-6 translocate from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37424", "l": "aclacinomycin N + O2 => aclacinomycin A + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2990882", "l": "CDK1 phosphorylates NUP98 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51838", "l": "(9Z)-tetradecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (9Z)-tetradecenoate(out) + ATP(in) + CoA(in) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975134", "l": "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46154", "l": "15,9'-di-cis-phytofluene + a plastoquinol => 15-cis-phytoene + a plastoquinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61566", "l": "a (1S,10aS)-3-(CONH2)-1-(Me2N)-3,3a,4,6-(HO)4-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracene + CO + H2O + NADP(+) => a tetracycline + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866105", "l": "CCPs deglutamylate tubulin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18534", "l": "5-hydroxy-L-tryptophan + H(+) => CO2 + serotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213207", "l": "Formation of collagen networks (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950741", "l": "IL12B:IL23A translocates from ER lumen to extracellular space (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450088", "l": "GLUT1 tetramer binds 4xATP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11975", "l": "4 Fe(2+) + 6 H2O + O2 <=> 12 H(+) + 4 iron(III) oxide-hydroxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852716", "l": "Thrombin, ELANE cleave C5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42189", "l": "3beta-hydroxy-5alpha-androstan-17-one + NAD(+) => 5alpha-androstan-3,17-dione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43839", "l": "cholesterol + H(+) + NADPH + O2 <=> 26-hydroxycholesterol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013157", "l": "CDC42 binds effectors at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0015179", "l": "L-amino acid transmembrane transporter activity"}, {"i": "REACT:R-HSA-212614", "l": "Glutamine transport from astrocytes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399939", "l": "Autophosphorylation of PAK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043822", "l": "ribonuclease M5 activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848436", "l": "PTK6 phosphorylates CDKN1B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.37"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50713", "l": "chloride + FADH2 + O2 + tetracycline => 7-chlorotetracycline + FAD + H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "78.423603998002051", "identifiers": [{"i": "GO:0015662", "l": "P-type ion transporter activity"}, {"i": "REACT:R-HSA-429157", "l": "ABCC4 accumulation of dense granule contents (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12074", "l": "a (2S)-2-hydroxycarboxylate + a halide anion + H(+) => an (S)-2-haloacid + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686174", "l": "Accessory proteins are recruited to the maturing virion (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62977", "l": "(9Z,12Z,15Z)-octadecatrienamide + H2O => (9Z,12Z,15Z)-octadecatrienoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40289", "l": "AMP + decanedioyl-CoA + diphosphate => ATP + CoA + decanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660694", "l": "Variant SLC6A20 does not cotransport L-Pro, Na+ from extracellulare region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034572", "l": "monodemethylisoproturon dimethylaminedehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163320", "l": "Association of mTERF with the termination sequence (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419861", "l": "Melanospin is stimulated by light (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14588", "l": "gibberellin A12 + 5 H(+) + 3 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> CO2 + gibberellin A9 + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54406", "l": "2-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605768", "l": "Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351849", "l": "Caspase-mediated cleavage of Etk (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483099", "l": "PA translocates from the outer to the inner mitochondrial membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22035", "l": "3-oxalomalate <=> glyoxylate + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58698", "l": "H(+) + H2O + NADP(+) + rifampicin para-naphthoquinone carboxamide => NADPH + O2 + rifampicin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080131", "l": "hydroxyjasmonate sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975122", "l": "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52659", "l": "a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+) <=> a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27796", "l": "all-trans-heptaprenyl diphosphate + 4 diphosphate => (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236935", "l": "Proteasomal cleavage of substrate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31720", "l": "11alpha-hydroxy-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 11-oxo-beta-amyrin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31163", "l": "(3S)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36979", "l": "(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23057", "l": "urea => cyanamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47185", "l": "5alpha-cholesta-7,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + cholesta-5,7,24-trien-3beta-ol + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351849", "l": "Caspase-mediated cleavage of Etk (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11855", "l": "phosphate + S-methyl-5'-thioadenosine <=> adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372819", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026901", "l": "GGT transfers GSH to 16S,17S-epoxy-DHA to form PCTR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4090288", "l": "PIAS1,3 SUMOylate MBD1 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0030566", "l": "snRNA modification guide activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49405", "l": "beta-D-mannopyranosyl-(1->2)-D-mannopyranose + phosphate => alpha-D-mannose 1-phosphate + D-mannose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016492", "l": "G protein-coupled neurotensin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354124", "l": "Phosphorylation of pPTK2 by SRC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20758", "l": "2-[(E)-caffeoyl]-D-threo-isocitrate(3-) + CoA => (E)-caffeoyl-CoA + D-threo-isocitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2077420", "l": "FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45262", "l": "tetracosanoate(in) => tetracosanoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380782", "l": "STAT binds to the active receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730856", "l": "Autophosphorylation of PAK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905762", "l": "CCR4-NOT complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20911", "l": "3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114284", "l": "Release of Cytochrome c from mitochondria (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25733", "l": "(E)-7-(methylsulfanyl)heptanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-tetrahomomethionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980041", "l": "NOTCH1 binds DLL4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029471", "l": "Hydrolysis of PC to PA by PLD (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51735", "l": "glandicoline B + S-adenosyl-L-methionine <=> H(+) + meleagrin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38513", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48384", "l": "2,3-saturated fatty acid + H2O2 = 3-hydroxy fatty acid + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24106", "l": "7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine => 7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14921", "l": "(indol-3-yl)acetate + UDP-alpha-D-glucose = 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP"}, {"i": "EC:2.4.1.121", "l": "\"Indole-3-acetate beta-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54290", "l": "diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein] => ATP + L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22886", "l": "4-methylsulfanyl-2-oxobutanoate + glycine => glyoxylate + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16644", "l": "a long-chain fatty acyl ethyl ester + H2O <=> a long-chain fatty acid + ethanol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709842", "l": "MAVS binds TOMM70 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21191", "l": "ATP + deamido-NAD(+) + NH4(+) <=> AMP + diphosphate + H(+) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2545253", "l": "Deacetylation of cohesin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47973", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139913", "l": "TP53 stimulates BBC3 (PUMA) expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25916", "l": "A + H2O + quinolin-6-ol = 6-hydroxyquinolin-2(1H)-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21668", "l": "ATP + H2O + sn-glycerol 3-phosphate(out) = ADP + H(+) + phosphate + sn-glycerol 3-phosphate(in)"}, {"i": "EC:7.6.2.10", "l": "\"ABC-type glycerol 3-phosphate transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168897", "l": "LRP1 (CD91) binds Hemopexin:heme (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396395", "l": "HSPG2 (perlecan) binds alpha-dystroglycan (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022874", "l": "protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35226", "l": "2-oxo-dADP + H2O <=> 2-hydroxy-dAMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174224", "l": "Dissociation of Cdc20 from APC/C complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40544", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033752", "l": "acetylacetone-cleaving enzyme activity"}, {"i": "RHEA:12877", "l": "acetylacetone + O2 = acetate + H(+) + methylglyoxal"}, {"i": "EC:1.13.11.50", "l": "\"Acetylacetone-cleaving enzyme\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013979", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24976", "l": "(1S)-1,25-dihydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]"}, {"i": "EC:1.14.15.16", "l": "\"Vitamin D(3) 24-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52840", "l": "4-hydroxy-3-methoxybenzoate + UDP-alpha-D-glucose = 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + UDP"}, {"i": "EC:2.4.1.136", "l": "\"Gallate 1-beta-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019948", "l": "SUMO activating enzyme activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36795", "l": "a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54829", "l": "dimethylamine + H(+) + NADPH + O2 => formaldehyde + H2O + methylamine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31559", "l": "L-galactose + NAD(+) = H(+) + L-galactono-1,4-lactone + NADH"}, {"i": "EC:1.1.1.316", "l": "\"L-galactose 1-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19652", "l": "ATP + L-aspartate + tRNA(Asp) <=> AMP + diphosphate + L-aspartyl-tRNA(Asp)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11679", "l": "D-ribose + H2O + NADP(+) <=> D-ribonate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13127", "l": "CoA-glutathione + glutathione => CoA + glutathione disulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139909", "l": "Translocation of BMF to mitochondria (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004104", "l": "cholinesterase activity"}, {"i": "RHEA:21964", "l": "an acylcholine + H2O = a carboxylate + choline + H(+)"}, {"i": "EC:3.1.1.8", "l": "\"Cholinesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3159253", "l": "MMAB transfers adenosyl group from ATP to cob(I)alamin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8985950", "l": "p-Y649-STAT5A, p-STAT5B dimerizes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781814", "l": "USP19 deubiquitinates RNF123 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5684096", "l": "CDK2 phosphorylates RBBP8 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13223", "l": "H(+) + mevaldate + NADH => (R)-mevalonate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005008", "l": "hepatocyte growth factor-activated receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617840", "l": "FOXO1,FOXO3,FOXO4 bind CDKN1A gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43115", "l": "(R)-mandelate + NAD(+) <=> H(+) + NADH + phenylglyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605736", "l": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429036", "l": "SLC2A9 transports Fru, Glc, urate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190265", "l": "FGFR4 binds to FGF (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35645", "l": "a 2-oxocarboxylate + H(+) + NADH => a (2R)-2-hydroxycarboxylate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22586", "l": "Fe(2+) + protoporphyrin IX => 2 H(+) + heme b"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15036", "l": "O2 + pyridoxine <=> H2O2 + pyridoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444606", "l": "T1R2/T1R3 dimer is a sweet taste receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.33"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070577", "l": "lysine-acetylated histone binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30720", "l": "acetyl-CoA + propanoyl-CoA => 2-methyl-3-oxobutanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61938", "l": "ADP + cycloheximide(out) + H(+) + phosphate => ATP + cycloheximide(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.158"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686343", "l": "IAV NS1 binds MLKL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41491", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21143", "l": "ATP + inosine <=> ADP + H(+) + IMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1861788", "l": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610752", "l": "GLI3R translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19869", "l": "an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)"}, {"i": "EC:2.3.1.13", "l": "\"Glycine N-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340124", "l": "CSN polymer binds CaPO4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63208", "l": "5-amino-6-(D-ribitylamino)uracil + glyoxal = 5-(2-oxoethylideneamino)-6-(D-ribitylamino)uracil + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140345", "l": "phosphatidylcholine flippase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168638", "l": "Activated IKK phosphorylates I-kappaB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3791155", "l": "Laminin-322 degradation by MMP14 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15800", "l": "bilirubin IXalpha + NAD(+) <=> biliverdin IXalpha + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5334827", "l": "SUMO-CRABP2 binds atRA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13604", "l": "4-hydroxy-L-proline + NAD(+) <=> 4-oxo-L-proline + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34590", "l": "2-oxoglutarate + O2 + pentalenolactone E <=> CO2 + pentalenolactone F + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20623", "l": "ADP + H(+) + phosphate + Zn(2+)(out) => ATP + H2O + Zn(2+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23480", "l": "2-methylene-3-methylsuccinate = dimethylmaleate"}, {"i": "EC:5.3.3.6", "l": "\"Methylitaconate Delta-isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875531", "l": "MET binds TNS4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13526", "l": "(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] => (1R,4R,5R)-5-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389862", "l": "Conversion of glyoxylate to oxalate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2984258", "l": "NEK9 phosphorylates NEK6/NEK7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54613", "l": "2-oxoglutarate + 3-methylbutanoyl-CoA + O2 => 2-hydroxy-3-methylbutanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015212", "l": "cytidine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28027", "l": "[thioredoxin]-disulfide + dUDP + H2O => [thioredoxin]-dithiol + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48282", "l": "ganglioside GM1 + H(+) + UDP => ganglioside GM2 + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012835", "l": "GDIs block activation of RHOA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55499", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-cassa-12,15-dien-2beta,3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45648", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28827", "l": "L-ornithine(out) + putrescine(in) = L-ornithine(in) + putrescine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33546", "l": "ergosteryl palmitate + H2O <=> ergosterol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102445", "l": "3-methylquercetin 3'-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-13930"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62536", "l": "2 [Fe(II)cytochrome c] + digoxigenin + 3 H(+) = 2 [Fe(III)cytochrome c] + dihydrodigoxigenin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42327", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + reduced coenzyme F420-(gamma-Glu)(n) <=> 3 H(+) + oxidized coenzyme F420-(gamma-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10773", "l": "6-phospho-beta-D-glucosyl-(1->4)-D-glucose + H2O => D-glucose + D-glucose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40608", "l": "1-tetradecanoyl-sn-glycerol + H2O => glycerol + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50342", "l": "1alpha-hydroxytestosterone + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + testosterone"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001862", "l": "collectin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46935", "l": "2-epi-5-epi-valiolone 7-phosphate <=> 5-epi-valiolone 7-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77608", "l": "Binding of A1CF to stem-looped RNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.9.-", "l": "\"With a copper protein as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70420", "l": "HK1,2,3,GCK phosphorylate Glc to form G6P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12422", "l": "ADP + D-tagatofuranose 1,6-bisphosphate + H(+) => ATP + D-tagatofuranose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30554", "l": "acetyl-CoA + beta-D-glucose <=> 6-O-acetyl-beta-D-glucose + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.16"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27983", "l": "7-carboxy-7-deazaguanine + ATP + NH4(+) => 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8873850", "l": "STARD5 binds DCA, LCA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689861", "l": "Recruitment of XPA and release of CAK  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46539", "l": "(6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38360", "l": "2 H(+) + hydrogen sulfide + sulfite + ubiquinone-10 => thiosulfate + ubiquinol-10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130349", "l": "Generation of CLIP from lip10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46302", "l": "2-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033799", "l": "myricetin 3'-O-methyltransferase activity"}, {"i": "RHEA:25629", "l": "myricetin + S-adenosyl-L-methionine = H(+) + laricitrin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14219", "l": "[thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein] => [thioredoxin]-disulfide + H2O + L-methionyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17858", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taurochenodeoxycholate => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taurohyocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132210", "l": "C3b fragment binds to the target cell surface (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15626", "l": "Co-precorrin-6B + NAD(+) => Co-precorrin-6A + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73865", "l": "Assembly of RNA Polymerase I Holoenzyme (human) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847534", "l": "RAB43 hydrolyses GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28354", "l": "decanoyl-CoA + FAD + H(+) = (2E)-decenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162657", "l": "Inactivation of Myt1 kinase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77609", "l": "Binding of APOBEC-1 to form editosome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57763", "l": "2 (S)-methylmalonyl-CoA + 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH <=> C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322434", "l": "XIAP dissociates from ub-TLE (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10636", "l": "D-mannonate + NADP(+) = D-mannuronate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64110", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine => H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.77", "l": "\"Semenogelase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24315", "l": "L-lysyl-[cytochrome c] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67111", "l": "L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54854", "l": "H2O + NADP(+) + propyl butanoate => H(+) + heptan-4-one + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44024", "l": "(3R)-3-hydroxydodecanoyl-CoA = (2E)-dodecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41530", "l": "NAD(+) + octanoyl-[ACP] => (2E)-octenoyl-[ACP] + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114552", "l": "Thrombin-activated PARs activate G12/13 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35132", "l": "H(+)(out) + L-alanyl-L-glutamate(out) => H(+)(in) + L-alanyl-L-glutamate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70427", "l": "PGM:Mg2+ isomerise G1P to G6P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37988", "l": "delta-tocopherol => 2-methyl-6-phytyl-1,4-benzene-1,4-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36061", "l": "AH2 + urocanate => A + dihydrourocanate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382058", "l": "Nck binds to the active PDGF receptor (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3159253", "l": "MMAB transfers adenosyl group from ATP to cob(I)alamin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000340", "l": "RNA 7-methylguanosine cap binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50234", "l": "biliverdin IXalpha + CO + Fe(2+) + 3 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => 8 H(+) + heme b + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37793", "l": "aclacinomycin Y + H2O2 => aclacinomycin A + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730892", "l": "Recruitment of VAV to p-SLP-76 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.56"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3878123", "l": "Initiation of SAHF formation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376851", "l": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33576", "l": "an inositol-1-phosphophytoceramide + beta-D-mannose => a mannosylinositol-1-phosphophytoceramide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709883", "l": "BIL:ALB scavenges O2.- (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140398", "l": "versicolorin B desaturase activity"}, {"i": "RHEA:35743", "l": "H(+) + NADPH + O2 + versicolorin B = 2 H2O + NADP(+) + versicolorin A"}, {"i": "EC:1.14.19.n5", "l": "\"Versicolorin B desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29260", "l": "(2R,3R)-tartrate(out) + succinate(in) => (2R,3R)-tartrate(in) + succinate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51234", "l": "2-glyceryl-prostaglandin D2 => 2-glyceryl-prostaglandin H2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28799", "l": "H2O + L-prolinylglycine = glycine + L-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10160", "l": "L-iditol + NAD(+) = H(+) + keto-L-sorbose + NADH"}, {"i": "EC:1.1.1.14", "l": "\"L-iditol 2-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380574", "l": "Dopamine synaptic vesicle docking and priming (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.22", "l": "\"Metallocarboxypeptidase D\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53889", "l": "D-glucose 6-phosphate + TDP-alpha-D-glucose => alpha,alpha-trehalose 6-phosphate + H(+) + TDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47931", "l": "(S)-3-sulfolactaldehyde + H2O + NADP(+) <=> (S)-3-sulfolactate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52179", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49283", "l": "FADH2 + O2 + phenol <=> catechol + FAD + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70481", "l": "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852324", "l": "GTSE1 binds PLK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48243", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1b <=> CMP + ganglioside GT1b + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-481009", "l": "Exocytosis of platelet dense granule content (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113402", "l": "Formation of DSIF:NELF:early elongation complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103033", "l": "beta-galactosidase activity (lactose isomerization)"}, {"i": "MetaCyc:RXN0-5363"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.5.3", "l": "\"Glycerol-3-phosphate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39454", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA <=> (2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445079", "l": "Phosphorylation of L1 by ERK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201790", "l": "DARPP-32 is dephosphorylated on Thr75 by PP2A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55490", "l": "ent-cassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19603", "l": "2,3,5-trihydroxytoluene + H2O + NAD(+) => H(+) + NADH + O2 + orcinol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097077", "l": "copper ion sensor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162229", "l": "The single sugars GlcA and GlcNAc translocate from the lysosome to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47929", "l": "(S)-3-sulfolactaldehyde + H2O + NADP(+) => (S)-3-sulfolactate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19757", "l": "(3R)-3-hydroxy-L-aspartate = NH4(+) + oxaloacetate"}, {"i": "EC:4.3.1.20", "l": "\"Erythro-3-hydroxy-L-aspartate ammonia-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654573", "l": "Activated FGFR1 binds SHC1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604606", "l": "Unknown kinase phosphorylates NICD4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53920", "l": "ATP + L-threonyl-[Fas-activated protein] = ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047531", "l": "2,5-diaminovalerate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43198", "l": "2'-O-methyladenosine(4) in tRNA(His) + H(+) + S-adenosyl-L-homocysteine => adenosine(4) in tRNA(His) + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40137", "l": "(9Z)-tetradecenoate + CoA + H(+) => (9Z)-tetradecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11191", "l": "3-cyano-L-alanine + 2 H2O <=> L-aspartate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692297", "l": "DMRT1 binds the WNT4 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21645", "l": "ATP + glycerol => ADP + H(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13896", "l": "H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate <=> ADP + AMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24191", "l": "cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) <=> 1,2-dihydroxydibenzothiophene + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602473", "l": "Autocatalytic activation of MMP1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694433", "l": "MIA2 binds PREB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9633044", "l": "ESR binds STRN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14984", "l": "NADP(+) + testosterone <=> androst-4-ene-3,17-dione + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624956", "l": "PDE6D binds INPP5E (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111264", "l": "Addition of nucleotides between position +11 and +30 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-112430", "l": "Formation of P-TEFb complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38741", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44138", "l": "CoA + hexadecanyl dodecanoate => dodecanoyl-CoA + hexadecan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614544", "l": "Sulfite is oxidized to sulfate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17830", "l": "A + CO + H2O => AH2 + CO2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031813", "l": "P2Y2 nucleotide receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40762", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoylglycerone 3-phosphate <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerone 3-phosphate + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66383", "l": "ATP + glutathione(in) + glycodeoxycholate(in) + H2O <=> ADP + glutathione(out) + glycodeoxycholate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42909", "l": "S-adenosyl-L-methionine + uridine(1939) in 23S rRNA => 5-methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004421", "l": "hydroxymethylglutaryl-CoA synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49184", "l": "chlorophyllide a + H(+) + H2O = 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + CO2 + methanol"}, {"i": "EC:3.1.1.100", "l": "\"Chlorophyllide a hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25081", "l": "(2S)-2-isopropyl-3-oxosuccinate + H(+) <=> 4-methyl-2-oxopentanoate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32178", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose <=> alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017067", "l": "tyrosine-ester sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23398", "l": "1,3,5-trihydroxybenzene + H(+) + phloretate => H2O + phloretin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33723", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-tetracosanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-tetracosanoylsphinganine-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427528", "l": "Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59221", "l": "(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O => (2Z)-2-hydroxypenta-2,4-dienoate + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22730", "l": "L-selenocysteinyl-tRNA(Sec) + phosphate => H(+) + L-seryl-tRNA(Sec) + selenophosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41271", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58530", "l": "(16R)-deshydroxymethyl-stemmadenine + formate + NADP(+) => 15alpha-stemmadenine intermediate I + H2O + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58173", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => beta-pinacene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964525", "l": "RBL1 gene expression is repressed by the DREAM complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106355", "l": "4-hydroxybenzoate 3-monooxygenase [NADH] activity"}, {"i": "RHEA:19473", "l": "4-hydroxybenzoate + H(+) + NADH + O2 = 3,4-dihydroxybenzoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27508", "l": "benzoate + ecgonine methyl ester + H(+) => cocaine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928615", "l": "EFNBs bind SFKs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23697", "l": "myo-inositol + O2 => D-glucuronate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388829", "l": "SHP2 phosphatase binds CTLA-4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201622", "l": "Caspase-mediated cleavage of gelsolin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35131", "l": "H(+)(out) + L-alanyl-L-glutamate(out) = H(+)(in) + L-alanyl-L-glutamate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944247", "l": "Association of procollagen type VI (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858435", "l": "TSPAN7 binds PICK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353500", "l": "Nuclear focus formation by interaction of chSNM1A with PIAS1 upon DNA lesion (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621406", "l": "EGR2 and SREBF2 dimer bind CYP51A1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624953", "l": "ARL13B binds INPP5E (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814674", "l": "Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11167", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine <=> 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28067", "l": "CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) => alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27823", "l": "hydrogen sulfide + O-acetyl-L-homoserine => acetate + L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20026", "l": "gibberellin A3 + UDP-alpha-D-glucose => gibberellin A3 O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39474", "l": "(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110475", "l": "DAkt1-mediated phosphorylation inactivates DFOXO (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13415", "l": "AMP + dTMP + H(+) => ADP + thymidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23429", "l": "3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55969", "l": "(+)-kolavelool + S-adenosyl-L-methionine => (+)-O-methylkolavelool + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390846", "l": "D2D3,4 bind to DA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.37", "l": "\"Aldose-1-phosphate nucleotidyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102229", "l": "amylopectin maltohydrolase activity"}, {"i": "MetaCyc:RXN-12278"}, {"i": "EC:3.2.1.2", "l": "\"Beta-amylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62110", "l": "a monoacyl-sn-glycero-3-phosphoethanolamine + CoA => an acyl-CoA + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27553", "l": "di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate => (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004607", "l": "phosphatidylcholine-sterol O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36889", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442749", "l": "CaMKK autophosphorylates in the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102148", "l": "N-acetyl-beta-D-galactosaminidase activity"}, {"i": "MetaCyc:RXN-11622"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44611", "l": "3-(all-trans-nonaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-nonaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58827", "l": "4 H(+) + luteothin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> aureothin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48842", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420906", "l": "Formation of PPAT tetramers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21476", "l": "[(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->3)-beta-D-glucosyl](n+1) + H(+) + UDP"}, {"i": "EC:2.4.1.34", "l": "\"1,3-beta-glucan synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48431", "l": "1-(9Z,12Z-octadecadienoyl)-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381727", "l": "RAP1A exchanges GDP for GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44990", "l": "CoA + O-isobutanoyl-(R)-carnitine => (R)-carnitine + 2-methylpropanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47329", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159773", "l": "Furin cleaves pro-protein S to protein S (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34689", "l": "A + 2 H2O + N-acyl-15-methylhexadecasphing-4-enine => AH2 + N-acyl-15-methylhexadecasphinganine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429698", "l": "PRKD1,2,3 phosphorylates COL4A3BP-2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635845", "l": "GLI proteins bind CDC73 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080082", "l": "esculin beta-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48920", "l": "ADP + bacteriochlorophyllide g + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate = 3,8-divinyl chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.3.7.14", "l": "\"3,8-divinyl chlorophyllide a reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2509831", "l": "ITPA hydrolyses XTP to XMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211239", "l": "Association of DFF40 with chromatin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57372", "l": "H2O + NADPH = (6S)-NADPHX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381644", "l": "ER calcium channels open in response to activated PKA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696356", "l": "OSCAR binds collagen and SP-D (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199131", "l": "PVR binds CD226 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34166", "l": "hydroquinone + O2 <=> (2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050816", "l": "phosphothreonine residue binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008898", "l": "S-adenosylmethionine-homocysteine S-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210430", "l": "Release of L-Glutamate at the synapse (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45537", "l": "H2O + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-octadecanoyl ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54983", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose <=> [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n+1)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12692", "l": "2 mycothiol + NAD(+) <=> H(+) + mycothione + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16955", "l": "L-glutamate + N-succinyl-L-glutamate 5-semialdehyde => 2-oxoglutarate + N(2)-succinyl-L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37141", "l": "1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24615", "l": "17beta-estradiol + NAD(+) <=> estrone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25636", "l": "laricitrin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + syringetin"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0031490", "l": "chromatin DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29552", "l": "H2O + UDP-alpha-D-glucose => alpha-D-galactose 1-phosphate + 2 H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-352059", "l": "SLC6A15-mediated amino acid uptake (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2127285", "l": "NOTCH2 stimulates transcription of FCER2 (CD23A) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60289", "l": "N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49264", "l": "5-O-[(E)-caffeoyl]-shikimate + H2O = (E)-caffeate + H(+) + shikimate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3341294", "l": "Superoxide reduces cytochrome c (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686430", "l": "MUS81 binds EME1, EME2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-381727", "l": "RAP1A exchanges GDP for GTP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114352", "l": "Sequestration of tBID by BCL-2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18408", "l": "H2O + L-alanine + NAD(+) <=> H(+) + NADH + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097266", "l": "phenylacetyl-CoA 1,2-epoxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247837", "l": "WNT ligands traffic to the Golgi (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51734", "l": "H(+) + meleagrin + S-adenosyl-L-homocysteine => glandicoline B + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53521", "l": "1-hexadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol => (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39431", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042409", "l": "caffeoyl-CoA O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031696", "l": "alpha-2C adrenergic receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004853", "l": "uroporphyrinogen decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35289", "l": "chloramphenicol(out) => chloramphenicol(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68914", "l": "DNA polymerase alpha:primase binds at the origin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33661", "l": "H2O + N-(2-hydroxytetracosanoyl)-sphinganine + NADP(+) => H(+) + N-tetracosanoylsphinganine + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17435", "l": "AH2 + betaine aldehyde => A + choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35769", "l": "8-O-methyldihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine => dihydrosterigmatocystin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26198", "l": "H2O + melamine => ammeline + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64714", "l": "H(+) + NADPH + propanal => 1-propanol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944262", "l": "Association of procollagen type X (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9022314", "l": "HIPK2 phosphorylates MECP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010523", "l": "ROBO2 gene transcription is stimulated by HOXA2 and inhibited by LHX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41636", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + H2O = 1-O-(1Z-alkenyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19390", "l": "(E)-ferulate + ATP + CoA => (E)-feruloyl-CoA + ADP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2995330", "l": "COX10 transforms heme to heme O (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419490", "l": "Binding of ATP to P2X receptors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865454", "l": "CBFB binds RUNX3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26501", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose <=> delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25699", "l": "H(+) + N,N-dihydroxy-L-hexahomomethionine => (E)-9-(methylsulfanyl)nonanal oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16881", "l": "hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate"}, {"i": "EC:2.8.1.1", "l": "\"Thiosulfate sulfurtransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43251", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O <=> 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68914", "l": "DNA polymerase alpha:primase binds at the origin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57131", "l": "H2O + 2 oxidized [azurin] + tyramine <=> (4-hydroxyphenyl)acetaldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047133", "l": "dimethylamine dehydrogenase activity"}, {"i": "MetaCyc:1.5.8.1-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23483", "l": "2-methylene-3-methylsuccinate <=> dimethylmaleate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31288", "l": "H(+) + oxidized [electron-transfer flavoprotein] + propanoyl-CoA => acryloyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27911", "l": "D-gluconate + NAD(+) => 2-dehydro-D-gluconate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31243", "l": "H2O + L-4-hydroxyglutamate semialdehyde + NAD(+) = (4S)-4-hydroxy-L-glutamate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24903", "l": "cyclic di-3',5'-guanylate + H2O => 5'-phosphoguanylyl(3'->5')guanosine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166214", "l": "FA anion flip-flops to the opposite surface (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983878", "l": "p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390329", "l": "Dephosphorylation of AKT by PP2A (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54583", "l": "5'-dephospho-(RNA) + ATP <=> 5'-end-(RNA) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008695", "l": "3-phenylpropionate dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73596", "l": "dCMP + H2O => dUMP + NH4+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33662", "l": "H(+) + N-tetracosanoylsphinganine + NADPH + O2 <=> H2O + N-(2-hydroxytetracosanoyl)-sphinganine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373713", "l": "DCC heterodimerizes with UNC-5:Netrin-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16422", "l": "an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18748", "l": "2 juglone + O2 <=> 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53394", "l": "(2-hydroxyphenyl)acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-phenylacetate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34577", "l": "2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalenolactone => 2 H(+) + O2 + pentalenolactone F + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37918", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46197", "l": "O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] => 7alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28575", "l": "H(+)(in) + sulfate(in) => H(+)(out) + sulfate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202291", "l": "Activation of Lck (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624131", "l": "UNC119B binds myristoylated proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11448", "l": "NAD(+) + pregnan-21-ol = H(+) + NADH + pregnan-21-al"}, {"i": "EC:1.1.1.150", "l": "\"21-hydroxysteroid dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45855", "l": "Co(II)-factor III + H(+) + S-adenosyl-L-methionine <=> Co(II)-factor IV + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17028", "l": "NADP(+) + xylitol <=> H(+) + L-xylulose + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28227", "l": "(+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46531", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690997", "l": "Ligation of newly synthesized repair patch to incised DNA in GG-NER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34869", "l": "AMP + diphosphate + thiophene-2-carbonyl-CoA => ATP + CoA + thiophene-2-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010645", "l": "AKAP5 recruits PPP3CB (PP2BB) to ROBO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24758", "l": "NADP(+) + red chlorophyll catabolite => H(+) + NADPH + O2 + pheophorbide a"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62841", "l": "GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031802", "l": "Maresins translocate from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44559", "l": "4-hydroxybenzoate + all-trans-hexaprenyl diphosphate <=> 4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71164", "l": "homogentisate + O2 => maleylacetoacetate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9626817", "l": "PKC phosphorylates NCF1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54066", "l": "10-epi-cubebol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32645", "l": "17-hydroxylupanine + 2 [Fe(II)cytochrome c] + 2 H(+) => 2 [Fe(III)cytochrome c] + H2O + lupanine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102964", "l": "S-adenosyl-L-methionine:(S)-corytuberine-N-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2152276", "l": "Secretion of transmembrane collagens (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428273", "l": "SPHK1 phosphorylates SPG to S1P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41108", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O => 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.143"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "81.790986234327661", "identifiers": [{"i": "GO:0098960", "l": "postsynaptic neurotransmitter receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58404", "l": "hexan-1-ol + NADP(+) = H(+) + hexanal + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58342", "l": "chenodeoxycholate + D-glucose => beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453338", "l": "PGYM b dimer:AMP complex <=> PGYM dimer, b form + 2 AMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59672", "l": "D-maltotriose + O2 = D-maltotriono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-170159", "l": "Translocation of Cdc25 to the nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57220", "l": "GTP + methylglyoxal = N(2)-(1-hydroxy-2-oxopropyl)-GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38223", "l": "(9Z)-octadecenoyl-CoA + decan-1-ol = 1-O-decyl-(9Z)-octadecenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37226", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3266566", "l": "G6PC2 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (islet) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60629", "l": "AH2 + gluconapin + O2 => A + H2O + xi-progoitrin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43714", "l": "diphosphate + dodecanoyl-AMP => ATP + dodecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102755", "l": "gibberellin-15(closed lactone form),2-oxoglutarate:oxygen oxidoreductase (3beta-hydroxylating) activity"}, {"i": "MetaCyc:RXN-7680"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624949", "l": "Assembly of the anterograde IFT train (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61318", "l": "germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-al + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110158", "l": "TDG glycosylase mediated recognition and binding of a thymine opposite to a guanine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62300", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + H(+) + NADPH = 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63383", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> a 1-O-alkyl-2-acetyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41876", "l": "(3R)-hydroxydodecanoyl-[ACP] = (2E)-dodecenoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30384", "l": "(2E,6E)-farnesyl diphosphate => (-)-7-epi-alpha-selinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852019", "l": "MET bound PI3K generates PIP3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10865", "l": "3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2 => 2-(acetamidomethylene)succinate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202721", "l": "JAM2 binds JAM3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047675", "l": "arabinonate dehydratase activity"}, {"i": "MetaCyc:ARABINONATE-DEHYDRATASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622627", "l": "BCL6 gene expression is stimulated by FOXO3,FOXO4,(FOXO1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018711", "l": "benzoyl acetate-CoA thiolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864029", "l": "PTPN12 dephosphorylates EGFR at Y1148 (Y1172) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35270", "l": "ethanol(in) <=> ethanol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45173", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938930", "l": "RUNX1 binds ELF2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32157", "l": "adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine => 7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191303", "l": "FDPS dimer transfers IPPP to GPP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21809", "l": "2,5-dioxopiperazine + H2O => glycylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66008", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + H2O2 + L-methionyl-[collagen] = [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708457", "l": "HM13 cleaves HMOX1 dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176956", "l": "Formation of GINS complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52819", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> an N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34507", "l": "2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate = N,N-diacetyllegionaminate + phosphate"}, {"i": "EC:2.5.1.101", "l": "\"N,N'-diacetyllegionaminate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169394", "l": "ISGylation of IRF3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.1.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611852", "l": "ADRB3 bind ADR,NAd (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53406", "l": "13-hydroxy-(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate => (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36878", "l": "(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114256", "l": "CYCS:APAF1 binds procaspase-9 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52232", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 = 3 A + Fe(2+) + 3 H2O + mycobilin a"}, {"i": "RHEA:52236", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 = 3 A + Fe(2+) + 3 H2O + mycobilin b"}, {"i": "EC:1.14.99.57", "l": "\"Heme oxygenase (mycobilin-producing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417908", "l": "P2RY1 binds ADP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10748", "l": "H(+) + hydrogencarbonate = CO2 + H2O"}, {"i": "EC:4.2.1.1", "l": "\"Carbonic anhydrase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9650473", "l": "SERPING1 is secreted (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64747", "l": "H2O + S-3-(hexan-1-ol)-L-cysteine <=> 3-sulfanyl-1-hexanol + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210805", "l": "Removal of miRNA passenger strand (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45629", "l": "holo-[CmaD peptidyl-carrier protein] + L-alloisoleucyl-[CmaA peptidyl-carrier protein] => holo-[CmaA peptidyl-carrier protein] + L-alloisoleucyl-[CmaD peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34819", "l": "dihydrocurcumin + NADP(+) = curcumin + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418845", "l": "Activation of caspase-3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10351", "l": "5-oxo-L-proline + ATP + 2 H2O <=> ADP + H(+) + L-glutamate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40249", "l": "10-carboxy-13-deoxycarminomycin + H(+) + methanol => H2O + rhodomycin D"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27880", "l": "3'-UMP + H(+) => 2',3'-cyclic UMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12195", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16553", "l": "aldehydo-D-ribose 5-phosphate + L-lysyl-[protein] = H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14407", "l": "D-glucono-1,5-lactone + H(+) + NADPH => D-glucose + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3296304", "l": "GPR31 is a receptor for 12(S)-HETE (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38780", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44731", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0017002", "l": "activin-activated receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38307", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680836", "l": "NS5B binds ribavirin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731924", "l": "EDNRA binds EDNs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703434", "l": "FLT3 fusions recruit PIK3CA through PIK3R1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102676", "l": "avenasterol-desaturase activity"}, {"i": "MetaCyc:RXN-4209"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5627775", "l": "Autophosphorylation of PAK1,2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37312", "l": "ATP + glycyl-L-glutamine(out) + H2O => ADP + glycyl-L-glutamine(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362500", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1566979", "l": "Laminin-332 degradation by laminin-322 degrading extracellular proteinases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987007", "l": "p-STAT1 dimerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63792", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate"}, {"i": "RHEA:63796", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-[tubulin] + L-glutamate"}, {"i": "EC:3.4.17.24", "l": "\"Tubulin-glutamate carboxypeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43398", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019863", "l": "IgE binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65345", "l": "H(+) + oxidized [electron-transfer flavoprotein] + valproyl-CoA => (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28995", "l": "H(+)(out) + L-threonine(in) = H(+)(in) + L-threonine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983153", "l": "E1 mediated ubiquitin activation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52599", "l": "lithocholoyl-CoA + NAD(+) <=> 3-oxocholan-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30314", "l": "7-methylxanthine + H(+) + NADH + O2 <=> formaldehyde + H2O + NAD(+) + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38558", "l": "an all-trans-retinyl ester + H2O <=> a fatty acid + all-trans-retinol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46933", "l": "2-epi-5-epi-valiolone 7-phosphate => 5-epi-valiolone 7-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15609", "l": "ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)"}, {"i": "EC:2.7.6.1", "l": "\"Ribose-phosphate diphosphokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392834", "l": "Activation of EPACs by cAMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26455", "l": "NADP(+) + propanoyl-CoA => acryloyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19226", "l": "glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine => 5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9670114", "l": "Histone H3.3 deposition at telomere (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63999", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.214"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855375", "l": "PTPN22 dissociates from CSK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33230", "l": "(E)-4-coumarate + H(+) <=> 4-hydroxystyrene + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37807", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3858489", "l": "ppDVL binds DAAM1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19444", "l": "benzene-1,2,4-triol + O2 <=> 3-hydroxy-cis,cis-muconate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174456", "l": "Joining of adjacent Okazaki fragments of the C-strand (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254290", "l": "CSN2 gene expression is stimulated by ERBB4s80:STAT5A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62023", "l": "H2O + sitosteryl 3-beta-D-glucoside <=> (24R)-ethylcholest-5-en-3beta-ol + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66124", "l": "2-oxobutanoate + L-histidine = (2S)-2-aminobutanoate + 3-(imidazol-5-yl)pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19512", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) <=> 2 H(+) + L-erythro-biopterin + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38770", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4341016", "l": "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507871", "l": "Aquaporins passively transport glycerol out of cells (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46139", "l": "aminopyrrolnitrin + H(+) + NADPH + 2 O2 <=> 2 H2O + NADP(+) + pyrrolnitrin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3204311", "l": "AOX1 oxidises PXL to PDXate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869568", "l": "NPM1 binds TFAP2A homodimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664867", "l": "NBR1 binds MAP1LC3B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799246", "l": "CHEK1 phosphorylates TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36001", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34487", "l": "dTDP-beta-L-rhamnose + N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol = alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + dTDP + H(+)"}, {"i": "EC:2.4.1.289", "l": "\"N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.78", "l": "\"GPR endopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30013", "l": "ADP + beta-D-galactose(in) + H(+) + phosphate => ATP + beta-D-galactose(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45660", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167292", "l": "Resumption of elongation of HIV-1 transcript after recovery from pausing (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60944", "l": "quercetin + S-adenosyl-L-methionine = H(+) + isorhamnetin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-167419", "l": "The receptor:G-protein complex releases GDP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10321", "l": "trans-3-hydroxy-L-proline => 1-pyrroline-2-carboxylate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209903", "l": "Noradrenaline is converted to adrenaline (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19634", "l": "(3S,5S)-3,5-diaminohexanoate + H2O + NAD(+) => (5S)-5-amino-3-oxohexanoate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66485", "l": "16alpha-hydroxygypsogenate + UDP-alpha-D-glucose => 16alpha-hydroxygypsogenate 28-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665032", "l": "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10854", "l": "diphosphate + sophoraflavanone G => dimethylallyl diphosphate + leachianone G"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784959", "l": "BPHL hydrolyses VACV to ACV (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098782", "l": "mechanosensitived potassium channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60773", "l": "2 2-oxoglutarate + gibberellin A12 + H(+) + 3 O2 => 3 CO2 + gibberellin A9 + 2 H2O + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65957", "l": "ATP + estrone 3-sulfate(out) + H2O => ADP + estrone 3-sulfate(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8858498", "l": "SL (surrogate light chain) binds IgH to form pre-BCR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19746", "l": "3,3',5-triiodo-L-thyronine + A + H(+) + iodide => AH2 + L-thyroxine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675431", "l": "PP2A dephosphorylates RAF1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24208", "l": "1,5-anhydro-D-mannitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH"}, {"i": "EC:1.1.1.292", "l": "\"1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1028817", "l": "CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66335", "l": "L-aspartate(out) <=> L-aspartate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35001", "l": "ADP(out) + ATP(in) => ADP(in) + ATP(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29071", "l": "a ubiquinone + formate + H(+) = a ubiquinol + CO2"}, {"i": "EC:1.17.5.3", "l": "\"Formate dehydrogenase-N\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814831", "l": "TBC1D20 binds RAB1:GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47733", "l": "cytidine(1400) in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(1400) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853496", "l": "SCF:FBXL7 binds AURKA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27499", "l": "3',5'-di-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine => 3'-O-methyltricetin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65791", "l": "diuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-(3,4-dichlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47866", "l": "dioctanoylglycerol + H(+) + octanoate => 1,2,3-trioctanoylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5252072", "l": "AZGP1 binds PIP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31846", "l": "2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA <=> 2-oxepin-2(3H)-ylideneacetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989747", "l": "Expression of FHL2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43373", "l": "an N-acylsphing-4-enine + dTDP-alpha-D-glucose => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61980", "l": "H(+) + NADPH + ubiquinone-10 = NADP(+) + ubiquinol-10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38092", "l": "delta-tocotrienol + S-adenosyl-L-methionine => beta-tocotrienol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047576", "l": "4-chlorobenzoate dehalogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53026", "l": "5-guanidino-2-oxopentanoate + a plastoquinol + NH4(+) => a plastoquinone + H2O + L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672951", "l": "Inactive RAFs bind YWHAB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26079", "l": "formaldehyde + H2O + NAD(+) + sulfite => methanesulfonate + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186773", "l": "PDGF dimer binds two receptors simultaneously (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9706393", "l": "RHOBTB3 binds ATP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350604", "l": "Agmatine + H2O <=> putrescine + urea (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855648", "l": "SALM3 binds LAR-RPTP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13926", "l": "(3R)-hydroxytetradecanoyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine => holo-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16493", "l": "glycerol 1,2-cyclic phosphate + H2O = glycerol 1-phosphate + H(+)"}, {"i": "EC:3.1.4.42", "l": "\"Glycerol-1,2-cyclic-phosphate 2-phosphodiesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928576", "l": "RHOA:GTP binds ROCK, activating it (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001965", "l": "G-protein alpha-subunit binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390663", "l": "ADRA2A,B,C bind ADR,NAd (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174741", "l": "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788999", "l": "HV1-mediated H+ transfer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62406", "l": "CO2 + H2O + pentadecanoate => (R)-2-hydroxyhexadecanoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870466", "l": "RGGT:CHM binds RABs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45006", "l": "CoA + O-2,6-dimethylheptanoyl-(R)-carnitine => (R)-carnitine + 2,6-dimethylheptanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30412", "l": "benzoyl-CoA + benzyl alcohol => benzyl benzoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50464", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) + 8 malonyl-CoA + 16 NADPH = 17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52685", "l": "NAD(+) + pyridoxine => H(+) + NADH + pyridoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40195", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60792", "l": "3 2-oxoglutarate + gibberellin A53 + 3 O2 = 3 CO2 + gibberellin A17 + H(+) + H2O + 3 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2130706", "l": "MHC class II antigen processing (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18763", "l": "a fatty acid + a monoacylglycerol + H(+) => a 1,2-diacyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018758", "l": "RHOH binds effectors at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373732", "l": "Nephrin trans-homophilic interaction (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74986", "l": "Elongation of pre-rRNA transcript (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0070815", "l": "peptidyl-lysine 5-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11841", "l": "benzaldehyde + H2O + NAD(+) => benzoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8948136", "l": "ULK1 Translocates to the mitochondria (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964287", "l": "G alpha (s):GTP:SRC dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1963589", "l": "ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34899", "l": "malonyl-CoA + S-adenosyl-L-methionine = malonyl-CoA methyl ester + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15429", "l": "heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.342", "l": "\"Anaerobilin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30589", "l": "2-demethylmenaquinone-8 + dimethyl sulfide + H2O => 2-demethylmenaquinol-8 + dimethyl sulfoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45333", "l": "7,8-dihydroneopterin + O2 => 7,8-dihydroxanthopterin + formate + glycolaldehyde + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66118", "l": "(2S)-2-aminobutanoate + 2-oxoglutaramate => 2-oxobutanoate + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130731", "l": "Formation of COPII vesicle (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57515", "l": "chlorobenzene + H(+) + NADH + O2 <=> (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855375", "l": "PTPN22 dissociates from CSK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373075", "l": "Metabotropic glutamate receptors bind glutamate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54171", "l": "a 5'-(N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine <=> a 5'-(N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350651", "l": "Caspase-mediated cleavage of MASK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15824", "l": "2 A + glycine <=> 2 AH2 + CO2 + hydrogen cyanide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031713", "l": "B2 bradykinin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56670", "l": "7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10235", "l": "5,6-dihydrouridine 5'-monophosphate + diphosphate <=> 5,6-dihydrouracil + 5-phospho-alpha-D-ribose 1-diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13433", "l": "2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+)"}, {"i": "RHEA:16069", "l": "cytidine + H(+) + H2O = NH4(+) + uridine"}, {"i": "EC:3.5.4.5", "l": "\"Cytidine deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41113", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + octadecanoate => 1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61671", "l": "ATP + CoA + salicylate <=> 2-hydroxybenzoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41767", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD3 (d18:1(4E)) <=> CMP + ganglioside GT3 (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30761", "l": "NH4(+) + thymine => 5-methylcytosine + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55744", "l": "coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-Glu)(n)"}, {"i": "EC:1.8.98.4", "l": "\"Coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12055", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + trichodiene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17275", "l": "4-hydroxyphenylacetate + 2 H(+) + NADH => (4-hydroxyphenyl)acetaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665698", "l": "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind GRB2:SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48215", "l": "a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O <=> a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37307", "l": "glycyl-L-asparagine + H2O = glycine + L-asparagine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798373", "l": "MDM2 ubiquitinates DYRK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51918", "l": "2-oxobutanoate + NH4(+) => (2S)-2-amino-3-butenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34582", "l": "2 2-oxoglutarate + 2 O2 + pentalenolactone D <=> 2 CO2 + H2O + pentalenolactone F + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55697", "l": "a mannosylinositol-1-phospho-N-acyl-sphingoid base + H2O => an N-acyl-sphingoid base + H(+) + mannosylinositol-1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33112", "l": "(2E,6E)-farnesyl diphosphate => beta-copaene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050201", "l": "fucokinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21531", "l": "[phosphate](n) + H2O <=> [phosphate](n-1) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10025", "l": "L-lysyl-[histone] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004810", "l": "tRNA adenylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62819", "l": "4 monapinone E + O2 <=> 2 dinapinone E + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27370", "l": "acetoin + CoA + NAD(+) => acetaldehyde + acetyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686005", "l": "nsp3 binds to nsp7-8 and nsp12-16 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16041", "l": "[(1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13529", "l": "(3S)-citramalate = H2O + mesaconate"}, {"i": "EC:4.2.1.34", "l": "\"(S)-2-methylmalate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16588", "l": "[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956025", "l": "AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9660557", "l": "RAS:GTP binds RAL GDS proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33483", "l": "an acyl-CoA + ergosterol = CoA + ergosteryl ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624112", "l": "CEBPA binds CDK4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66517", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11650", "l": "1,4-menthane-3,8-diol + H2O + NADP(+) => (-)-menthol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033426", "l": "CAC codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53940", "l": "O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 = 18-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43799", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33037", "l": "2,2'-dioxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => 2-oxospirilloxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21794", "l": "acetone + H(+) + NADPH => NADP(+) + propan-2-ol"}]}
{"type": "biolink:MolecularActivity", "ic": "67.798152434899578", "identifiers": [{"i": "GO:0003690", "l": "double-stranded DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429157", "l": "ABCC4 accumulation of dense granule contents (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701488", "l": "Active ALK phosphorylates JAK3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39633", "l": "(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+) => (2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070674", "l": "hypoxanthine dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55764", "l": "1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol"}, {"i": "EC:3.3.2.9", "l": "\"Microsomal epoxide hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44586", "l": "(9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-(1'-sn-glycerol) => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008442", "l": "3-hydroxyisobutyrate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982617", "l": "CYGB:O2 dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8963734", "l": "IL9 binds IL9R:JAK1 and IL2RG:JAK3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60248", "l": "A + H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] = AH2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421457", "l": "Mitochondrial uptake and processing of ALAS2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173636", "l": "Formation of classic pathway C5 convertase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30280", "l": "2 H2 + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] => 3 H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25251", "l": "(2S)-2-acetolactate + CO2 => H(+) + 2 pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9035227", "l": "TXN2 binds CysS248-MPST (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187828", "l": "Translocation of p21 to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45230", "l": "a 4-saturated (2E)-enoyl-CoA => a (3E)-enoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000247", "l": "Endosomal CBLIF:Cbl translocates to lysosome (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14957", "l": "H(+) + NADH + O2 + tetradecanoyl-CoA = (11Z)-tetradecenoyl-CoA + 2 H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37545", "l": "2-amino-5-chloromuconate 6-semialdehyde => 2-amino-5-chlorophenol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29331", "l": "fumarate(in) + 2 H(+)(in) = fumarate(out) + 2 H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59882", "l": "3,4-dihydroxyphenylacetate + FMN + H(+) + H2O => 4-hydroxyphenylacetate + FMNH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426146", "l": "SREBP1A,1C,2 binds the FDFT1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45600", "l": "D-galactaro-1,4-lactone = 5-dehydro-4-deoxy-D-glucarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980138", "l": "NOTCH1 binds DLL/JAG ligand in cis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14668", "l": "guanine + H(+) + H2O <=> NH4(+) + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200858", "l": "Nef Binds and activates the Src-family tyrosine kinase Hck (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810076", "l": "DDO oxidizes D-Asp to OA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63908", "l": "ATP + H2O + pravastatin(in) = ADP + H(+) + phosphate + pravastatin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29853", "l": "2 H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UMP => H2O + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036455", "l": "iron-sulfur transferase activity"}, {"i": "REACT:R-HSA-2564828", "l": "CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60454", "l": "acetaldehyde + H(+) + sulfite => 2-hydroxyethane-1-sulfonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11758", "l": "AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein] => ATP + biotin + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58288", "l": "25-substituted-cholesterol + beta-D-glucosyl-N-octanoylsphing-4E-enine = 25-substituted-cholesteryl beta-D-glucoside + N-octanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204549", "l": "Caveolin-1 binds Basigin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22060", "l": "(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:2.8.1.6", "l": "\"Biotin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047284", "l": "dolichyl-xylosyl-phosphate-protein xylosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034802", "l": "branched-chain dodecylbenzene sulfonate monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37566", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21769", "l": "H2O + N-methyl-L-alanine + NADP(+) => H(+) + methylamine + NADPH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37787", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-171141", "l": "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64742", "l": "3-methyl-3-sulfanylhexan-1-ol + NH4(+) + pyruvate => H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57715", "l": "(E)-sinapoaldehyde + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-4-trans-sinapoyl aldehyde + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22999", "l": "H2O2 + L-ascorbate <=> 2 H2O + L-dehydroascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186778", "l": "SHP2 binds to the active receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27555", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 2 isopentenyl diphosphate = all-trans-hexaprenyl diphosphate + 2 diphosphate"}, {"i": "EC:2.5.1.82", "l": "\"Hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205262", "l": "Direct recruitment of PI3K to p-KIT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34404", "l": "9-cis-10'-apo-beta-carotenal + 2 O2 => (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal + carlactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17339", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H(+) => catechol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044603", "l": "protein adenylylhydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42519", "l": "H2O + L-gulono-1,4-lactone <=> H(+) + L-gulonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14714", "l": "A + keto-L-sorbose => 5-dehydro-D-fructose + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985644", "l": "COL1A1 gene expression is stimulated by RUNX2 and RB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030759", "l": "methylquercetagetin 6-O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47325", "l": "(S)-3-amino-3-phenylpropanoate + pyruvate => 3-oxo-3-phenylpropanoate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25397", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate => (9Z,12Z)-octadecadienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14115", "l": "(DNA)-3'-(deoxyribonucleoside 5'-phosphate) + phosphate => (DNA)-3'-(deoxyribonucleoside 3',5'-bisphosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050155", "l": "ornithine(lysine) transaminase activity"}, {"i": "MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN"}, {"i": "EC:2.6.1.13", "l": "\"Ornithine aminotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27852", "l": "CoA + H(+) + phenylacetylglycine => glycine + phenylacetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31487", "l": "soyasapogenol B 3-O-beta-D-glucuronate + UDP-alpha-D-galactose = H(+) + soyasaponin III + UDP"}, {"i": "EC:2.4.1.272", "l": "\"Soyasapogenol B glucuronide galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036380", "l": "UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46900", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) = a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) (E. coli)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696547", "l": "STAMBPL1 is a deubiquitinase (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2514790", "l": "Elastin degradation by MMP14 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003877", "l": "ATP adenylyltransferase activity"}, {"i": "MetaCyc:ATP-ADENYLYLTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358791", "l": "Phosphorylation of USP8 by P-AKT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55606", "l": "a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-acylsphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-acyl-sphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39279", "l": "ATP + dodecanoate(out) + H2O = ADP + dodecanoate(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043960", "l": "L-erythro-3-methylmalyl-CoA dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29234", "l": "cyanate(in) + H(+)(in) <=> cyanate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428510", "l": "ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58077", "l": "1-(11Z-eicosenoyl)-glycerol + H2O => (11Z)-eicosenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10024", "l": "L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.98"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51319", "l": "(9Z)-octadecenoate + glycine <=> H2O + N-(9Z-octadecenoyl)glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18797", "l": "a 3'-hydroxy,5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a 3',5'-dihydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15393", "l": "(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate"}, {"i": "EC:5.1.1.7", "l": "\"Diaminopimelate epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14298", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O => an N-acylsphing-4-enine + D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18488", "l": "6-acetyl-D-glucose + H2O <=> acetate + D-glucose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39755", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47448", "l": "(5Z)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36857", "l": "acetate + an S-substituted L-cysteine => an N-acetyl-L-cysteine-S-conjugate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626227", "l": "CP110 and CEP97 dissociate from the centriole (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50022", "l": "adenosine 3',5'-bisphosphate + decanoyl-4'-phosphopantetheine + 2 H(+) => decanoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20845", "l": "ATP + hydrogencarbonate + pyruvate => ADP + H(+) + oxaloacetate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57170", "l": "2-oxoglutarate + FADH2 => (R)-2-hydroxyglutarate + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20644", "l": "H2O + L-histidinol + 2 NAD(+) <=> 3 H(+) + L-histidine + 2 NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350769", "l": "trans-Golgi Network Coat Activation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.157"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111883", "l": "Hydrolysis of phosphatidylcholine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018690", "l": "4-methoxybenzoate monooxygenase (O-demethylating) activity"}, {"i": "RHEA:18613", "l": "4-methoxybenzoate + AH2 + O2 = 4-hydroxybenzoate + A + formaldehyde + H2O"}, {"i": "EC:1.14.99.15", "l": "\"4-methoxybenzoate monooxygenase (O-demethylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20719", "l": "H(+) + H2O + S-adenosyl-L-homocysteine <=> NH4(+) + S-inosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33666", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine + O2 <=> 2 [Fe(III)-cytochrome b5] + H2O + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0050833", "l": "pyruvate transmembrane transporter activity"}, {"i": "REACT:R-HSA-372342", "l": "MPC1:MPC2 cotransports PYR, H+ from cytosol to mitochondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13719", "l": "1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH => 2-C-methyl-D-erythritol 4-phosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227694", "l": "dsRNA binds to MDA5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30045", "l": "iminosuccinate + succinate => fumarate + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46699", "l": "a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine <=> an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186798", "l": "GAP binds to PDGF-beta receptors only (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.-", "l": "\"Enzymes altering polypeptide conformation or assembly\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57109", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34448", "l": "dTDP-6-deoxy-beta-L-talose + NAD(+) => dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428752", "l": "Dissociation of the TP:Gq complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52281", "l": "(6S)-5,6,7,8-tetrahydrofolate + 3-O-methylgallate => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4,5-trihydroxybenzoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3321883", "l": "MSL acetylates histone H4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712083", "l": "ALK mutants bind PI3KCA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52627", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-glutamate <=> [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5225649", "l": "RBBP7 binds histone H3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12947", "l": "biphenyl-2-ol + H(+) + sulfite => 2'-hydroxybiphenyl-2-sulfinate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433374", "l": "Processing of SCF isoform 1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043724", "l": "2-keto-3-deoxygalactonate aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53522", "l": "(9Z,12Z,15Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35105", "l": "fusidate(out) => fusidate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2981040", "l": "COLEC12:ligand is endocytosed (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57770", "l": "3-methylcatechol + NAD(+) + nitrite => 2-nitrotoluene + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043713", "l": "(R)-2-hydroxyisocaproate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814088", "l": "SYS1 binds AcM-ARFRP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8868236", "l": "BAR domain proteins recruit dynamin (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.150", "l": "\"Oligoxyloglucan reducing-end-specific cellobiohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40548", "l": "10-deoxymethymycin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + novamethymycin + 4 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17459", "l": "[sulfur-carrier protein]-S-sulfanyl-L-cysteine + L-alanine => [sulfur-carrier protein]-L-cysteine + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432010", "l": "Aquaporin-1 passively transports water into cell (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21676", "l": "2 dimethylallyl diphosphate = (R)-lavandulyl diphosphate + diphosphate"}, {"i": "EC:2.5.1.69", "l": "\"Lavandulyl diphosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866304", "l": "pre-VLDL binds lipids to form VLDL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58870", "l": "4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O => 24-methylidenelophenol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050135", "l": "NAD(P)+ nucleosidase activity"}, {"i": "MetaCyc:NADP+-NUCLEOSIDASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16500", "l": "adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39792", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047870", "l": "discadenine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37212", "l": "2',3'-cyclic GMP + H2O => guanosine 2'-monophosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379387", "l": "COMT transfers Met to DA to form 3MT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53194", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16462", "l": "ATP + H2O + urate(in) => ADP + H(+) + phosphate + urate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26230", "l": "3 NADP(+) + phytyl diphosphate => geranylgeranyl diphosphate + 3 H(+) + 3 NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003868", "l": "4-hydroxyphenylpyruvate dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47347", "l": "3beta-hydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta,26-dihydroxycholest-5-en-7-one + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17555", "l": "ADP + H(+) + N'-phosphoguanidinoethyl methylphosphate => ATP + guanidinoethyl methyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084903", "l": "Collagen types VI, IX bind integrin alpha10beta1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20943", "l": "1D-myo-inositol 1,3,4-trisphosphate + ATP <=> 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374662", "l": "Translocation of Ezrin to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57230", "l": "N(2)-(1-hydroxy-2-oxoethyl)-GDP => GDP + glyoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22301", "l": "a flavonol + UDP-alpha-D-glucose => a flavonol 3-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442725", "l": "CaMKII binds activated calmodulin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52755", "l": "H2O + isomaltose <=> beta-D-glucose + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5632649", "l": "Hh-Npp binds GAS1 and PTCH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37145", "l": "1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534096", "l": "METAP1/2 demethylates GNAT1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5246478", "l": "APOM binds retinoids (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018445", "l": "prothoracicotrophic hormone activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211583", "l": "Partial autophosphorylation of PAK-2 at  Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3371590", "l": "HSP70 binds to HSP40:nascent protein (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2426569", "l": "Interaction of DAP12 and IREM2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64015", "l": "acetyl-CoA + AH2 + 3 malonyl-CoA + 3 S-adenosyl-L-methionine <=> A + 3 CO2 + 4 CoA + fumigermin + H2O + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55461", "l": "11-hydroxyferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 11-hydroxysugiol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33572", "l": "A + methanol => AH2 + formaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21025", "l": "CoA + glyoxylate + NADP(+) => H(+) + NADPH + oxalyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21569", "l": "beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O => beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.42"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13721", "l": "H2O + testololactone = H(+) + testolate"}, {"i": "EC:3.1.1.37", "l": "\"Steroid-lactonase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31356", "l": "dimethyl sulfide + H(+) + NADH + O2 => formaldehyde + H2O + methanethiol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44036", "l": "12,13-epoxy-(9Z)-octadecenoate + H2O = 12,13-dihydroxy-(9Z)-octadecenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61499", "l": "an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose <=> an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64968", "l": "dUTP + H2O = dUDP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015024", "l": "glucuronate-2-sulfatase activity"}, {"i": "MetaCyc:3.1.6.18-RXN"}, {"i": "EC:3.1.6.18", "l": "\"Glucuronate-2-sulfatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21445", "l": "3-(2-hydroxyphenyl)propanoate + NAD(+) => H(+) + NADH + trans-2-coumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45684", "l": "N-dodecanoyl-sphing-4-enine-1-phosphate(in) = N-dodecanoyl-sphing-4-enine-1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52646", "l": "5-phospho-D-xylonate + H(+) => D-xylono-1,4-lactone 5-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902417", "l": "(+)-abscisic acid D-glucopyranosyl ester transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18963", "l": "H2O + N(6)-(D-psicosyl)-L-lysyl-[protein] => D-allose + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2569057", "l": "RIP3 binds TRIF to mediate necroptosis (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170159", "l": "Translocation of Cdc25 to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1606312", "l": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50834", "l": "17-hydroperoxy-(7Z,10Z,13Z,15E,19Z)-docosapentaenoate => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30700", "l": "2-oxoglutarate + beta-alanine => 3-oxopropanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36465", "l": "glycine + L-glutamate => glycyl-L-glutamate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013361", "l": "NEXT3 is cleaved to produce NICD3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44931", "l": "2-oxoheptanedioate + acetyl-CoA + H2O <=> (R)-trihomocitrate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607746", "l": "PKC-delta is activated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848335", "l": "IL37 binds  IL18R1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167477", "l": "Abortive HIV-1 initiation after formation of the first phosphodiester bond (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62051", "l": "an N-aryl-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O <=> an N-aryl-1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042937", "l": "tripeptide transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2995330", "l": "COX10 transforms heme to heme O (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0050136", "l": "NADH dehydrogenase (quinone) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28618", "l": "2-methylbutyronitrile + H(+) + NADPH + O2 = 2-hydroxy-2-methylbutanenitrile + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20267", "l": "cis-3-hydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + L-proline + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28861", "l": "Ag(+)(out) + H(+)(out) => Ag(+)(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205244", "l": "Recruitment of CBL to KIT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669024", "l": "CD70 binds CD27 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "78.819800280251172", "identifiers": [{"i": "GO:0016775", "l": "phosphotransferase activity, nitrogenous group as acceptor"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5695964", "l": "ABHD14B hydrolyses PNPB (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202534", "l": "Ubiquitination of NEMO by TRAF6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29947", "l": "H(+)(in) + L-rhamnopyranose(in) = H(+)(out) + L-rhamnopyranose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23062", "l": "a cis-3-alkyl-4-alkyloxetan-2-one + AMP + diphosphate => a (2R,3S)-2-alkyl-3-hydroxyalkanoate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944219", "l": "Association of procollagen type XVI (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56457", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole => 12-epi-fischerindole U"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189406", "l": "4 PBGs bind to form HMB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693347", "l": "CRYM reduces P2C to PPCA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.15", "l": "\"Desampylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2995388", "l": "PP2A dephosphorylates BANF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47854", "l": "a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate => a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51501", "l": "ATP + N-acetyl-D-muramate => ADP + H(+) + N-acetyl-D-muramate 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050436", "l": "microfibril binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717383", "l": "TRPM4 transports Na+ from the extracellular region to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209330", "l": "Phosphorylated BSK kinase and the AP-1 transcription factor, JRA:KAY, bind to CKA scaffolding protein in the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166041", "l": "Transfer of LPS onto TLR4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16668", "l": "(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O <=> (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022841", "l": "potassium ion leak channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977375", "l": "CR1 binds C3bBb/C4bC2a (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630045", "l": "Defective NTHL1 truncation mutants do not bind dihydrouracil (DHU) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58442", "l": "3 H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine => N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27361", "l": "chloride + S-adenosyl-L-methionine = chloromethane + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.165", "l": "\"Methyl halide transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23534", "l": "AMP + choloyl-CoA + diphosphate => ATP + cholate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24742", "l": "2-aminobut-2-enoate + H2O = 2-oxobutanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420977", "l": "Ca permeable AMPA receptor ligand binding (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3244605", "l": "TREX1 binds retroviral-derived DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004160", "l": "dihydroxy-acid dehydratase activity"}, {"i": "RHEA:20936", "l": "2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O"}, {"i": "EC:4.2.1.9", "l": "\"Dihydroxy-acid dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27863", "l": "3'-GMP + H2O => guanosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33838", "l": "H2O + N-hexacosanoyl-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + hexacosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5688834", "l": "ATXN3 binds VCP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30236", "l": "H2O + L-glutamate 5-semialdehyde + NAD(+) => 2 H(+) + L-glutamate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55104", "l": "3-oxoheptanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyheptanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35920", "l": "2'-deamino-2'-hydroxyneamine + UDP-alpha-D-glucose => H(+) + kanamycin D + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610735", "l": "NUMB binds ITCH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15443", "l": "H2O2 + orotate => (S)-dihydroorotate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372542", "l": "Loading of dopamine into synaptic veiscles (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47020", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O = [DsrC protein]-disulfide + 3 AH2 + 2 H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31528", "l": "N(omega)-hydroxy-L-arginine => (S)-1-pyrroline-5-carboxylate + guanidine + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76426", "l": "N-atom dealkylation of caffeine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-354097", "l": "Activation of Talin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30166", "l": "germacra-1(10),4,11(13)-trien-12-al + H2O + NADP(+) <=> germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49387", "l": "(12R)-hydroxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (12R),18-dihydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62850", "l": "GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl 8-{[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamyl]oxy}nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9632038", "l": "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218891", "l": "RIPK1:RIPK3 oligomer binds MLKL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27737", "l": "4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O <=> 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63922", "l": "CoA + H(+) + N-octadecanoyl-sphinga-4E,14Z-dienine => octadecanoyl-CoA + sphinga-4E,14Z-dienine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043777", "l": "cobalt-precorrin-7 C15-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190260", "l": "FGFR2b binds to FGF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389845", "l": "TUFM:GTP binds aminoacyl-tRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61342", "l": "CO2 + propanoyl-CoA => (S)-methylmalonyl-CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451309", "l": "Edited Kainate Receptor binds glutamate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-167419", "l": "The receptor:G-protein complex releases GDP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190829", "l": "Lysosomal degradation of gap junction plaques (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "79.682896251205548", "identifiers": [{"i": "GO:0016671", "l": "oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"}, {"i": "EC:1.8.4.-", "l": "\"With a disulfide as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380574", "l": "Dopamine synaptic vesicle docking and priming (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25231", "l": "H(+) + L-arabinose + NADPH => L-arabinitol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938217", "l": "RUNX1 binds the SWI/SNF complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400204", "l": "PPARA binds RXRA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668735", "l": "RAC1:GTP binds NOX3 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50290", "l": "(8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44993", "l": "(R)-carnitine + 2-methylbutanoyl-CoA => CoA + O-2-methylbutanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6791235", "l": "GADD45A binds AURKA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17898", "l": "A + ethylbenzene + H2O => (S)-1-phenylethanol + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015330", "l": "high-affinity glutamine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4332363", "l": "Autophosphorylation and activation of CAMK2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210439", "l": "glutamate uptake by astrocytes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43503", "l": "beta-D-glucuronate + NAD(+) <=> D-glucaro-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18372", "l": "O2 + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668735", "l": "RAC1:GTP binds NOX3 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371435", "l": "Constitutive phosphorylation by GSK3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57234", "l": "N(2)-(1-hydroxy-2-oxopropyl)-GDP => GDP + methylglyoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662598", "l": "MT2A binds zinc (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32139", "l": "ATP + CoA + malonate = AMP + diphosphate + malonyl-CoA"}, {"i": "EC:6.2.1.n3", "l": "\"Malonate--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29653", "l": "agmatine(out) + L-arginine(in) => agmatine(in) + L-arginine(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102117", "l": "gibberellin A9 carboxyl methyltransferase activity"}, {"i": "MetaCyc:RXN-11358"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112392", "l": "Resumption of elongation after recovery from pausing (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004341", "l": "gluconolactonase activity"}, {"i": "MetaCyc:GLUCONOLACT-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388829", "l": "SHP2 phosphatase binds CTLA-4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163688", "l": "Dephosphorylation of pChREBP (Thr 666) by PP2A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690896", "l": "SOX9 and GATA4 bind the DMRT1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022809", "l": "mobile ion carrier activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102410", "l": "quercetin-4',3-O-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-13765"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43880", "l": "3beta-hydroxy-5-cholestenoate + ATP + CoA = 3beta-hydroxy-5-cholestenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2250301", "l": "Formation of lysyl-pyrrole cross-links (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33155", "l": "a 1-acyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate"}, {"i": "EC:3.1.3.106", "l": "\"2-lysophosphatidate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18591", "l": "[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate => [glutamine synthetase]-L-tyrosine + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862700", "l": "CMKLR1 binds Resolvin E1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004365", "l": "glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36267", "l": "caffeine + H(+) + NADH + O2 = formaldehyde + H2O + NAD(+) + theobromine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24984", "l": "(1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43572", "l": "A + D-arginine + H2O = 5-guanidino-2-oxopentanoate + AH2 + NH4(+)"}, {"i": "EC:1.4.99.6", "l": "\"D-arginine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5604954", "l": "Defective UGT1A4 does not transfer GlcA from UDP-GlcA to BIL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57140", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15748", "l": "[(2->1)-beta-D-fructosyl](n) + sucrose <=> [(2->1)-beta-D-fructosyl](n+1) + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48167", "l": "epoxypheophorbide a + H2O <=> H(+) + red chlorophyll catabolite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63287", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58427", "l": "(E)-hex-2-en-1-ol + NADP(+) <=> (E)-hex--2-enal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58174", "l": "beta-pinacene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24232", "l": "2-dehydro-3-deoxy-D-gluconate + NAD(+) = 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH"}, {"i": "EC:1.1.1.127", "l": "\"2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.23", "l": "\"Nitroarene dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59092", "l": "[(1->3)-alpha-D-glucosyl](n) + sucrose = [(1->3)-alpha-D-glucosyl](n+1) + D-fructose"}, {"i": "EC:2.4.1.372", "l": "\"Mutansucrase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857686", "l": "FITM1, FITM2 bind TAGs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58581", "l": "dihydroprecondylocarpine acetate => acetate + catharanthine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875817", "l": "MET phosphorylates STAT3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21030", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein] => acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18024", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) <=> CMP + ganglioside GD1a (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961636", "l": "E2F1 binds the POLA1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11019", "l": "allantoate + H2O <=> (S)-ureidoglycolate + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351901", "l": "Caspase-mediated cleavage of MST3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865107", "l": "MICAL1 produces NADP+, H2O2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602458", "l": "Activation of proMMP10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24486", "l": "H(+) + NADH + sulcatone => NAD(+) + sulcatol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844440", "l": "NLRP3 activation by elicitor proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.31"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30329", "l": "all-trans-zeaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9603784", "l": "PEX19:class I PMP binds PEX3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019983", "l": "interleukin-9 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60887", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine-phospho-ribonucleoside in mRNA + H2O <=> (N(7)-methyl 5'-triphospho-guanosine)-adenosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668735", "l": "RAC1:GTP binds NOX3 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029445", "l": "An unknown GEF exchanges GTP for GDP on CDC42:GDP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20708", "l": "ATP + erythritol = ADP + D-erythritol 4-phosphate + H(+)"}, {"i": "EC:2.7.1.27", "l": "\"Erythritol kinase (D-erythritol 4-phosphate-forming)\""}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0099142", "l": "intracellularly ATP-gated ion channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33132", "l": "L-phenylalanine + tetrahydro-4-hydroxyphenylpyruvate => 3-phenylpyruvate + tetrahydrotyrosine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001540", "l": "amyloid-beta binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62239", "l": "a cytidine(6-4)cytidine in DNA <=> a cytidine dimer in DNA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661230", "l": "MT1A binds arsenic (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675947", "l": "TNFSF18 binds TNFRSF18 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35860", "l": "1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50389", "l": "5a,11a-dehydrotetracycline + H(+) + NADPH + O2 => 5a,11a-dehydrooxytetracycline + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11339", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine <=> deacetoxyvindoline + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189488", "l": "UROS transforms HMB to URO3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5213466", "l": "RIPK3 is phosphorylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44382", "l": "a ubiquinol + H(+) + S-adenosyl-L-homocysteine => a 3-demethylubiquinol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67016", "l": "a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] = a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21474", "l": "(3S)-citryl-CoA + ADP + phosphate => ATP + citrate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168184", "l": "Activated TAK1 mediates phosphorylation of the IKK Complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11377", "l": "(19S)-geissoschizine + NADP(+) => 4,21-dehydrogeissoschizine + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30163", "l": "germacra-1(10),4,11(13)-trien-12-al + H2O + NADP(+) = germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5579081", "l": "Defective ACY1 does not hydrolyse mercapturic acids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047112", "l": "pyruvate oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46910", "l": "7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + a 1,2-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983835", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51466", "l": "1beta-hydroxydeoxycholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => deoxycholate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.6.2.14", "l": "\"ABC-type aliphatic sulfonate transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14350", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose => an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53308", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1449574", "l": "SLC2A4 (GLUT4) vesicle fuses with the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400046", "l": "L-type Calcium Channels close in pancreatic beta cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48432", "l": "ATP + N(6)-D-ribulosyl-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24626", "l": "AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr) => ATP + L-threonine + tRNA(Thr)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730856", "l": "Autophosphorylation of PAK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209840", "l": "Two DITs combine to form thyroxine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29849", "l": "(3Z)-tetradecenoyl-CoA => (2E)-tetradecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0048763", "l": "calcium-induced calcium release activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.1.-", "l": "\"Other lyases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928641", "l": "PAK binds RAC and bPIX (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64151", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-R + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44625", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP(+) => dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46372", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.61", "l": "\"Linolenate 9R-lipoxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426032", "l": "DAG is metabolized by DAGL to 2-AG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63150", "l": "(9Z)-octadecenoate + taurine => H2O + N-(9Z-octadecenoyl)-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9007882", "l": "IL1F10 is cleaved (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5663050", "l": "DHI and DHICA polymerise forming eumelanin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70241", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56424", "l": "H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = (9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22936", "l": "H2O + N-acetyl-D-glucosamine 6-phosphate = acetate + D-glucosamine 6-phosphate"}, {"i": "EC:3.5.1.25", "l": "\"N-acetylglucosamine-6-phosphate deacetylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003883", "l": "CTP synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24572", "l": "[(1->4)-alpha-D-glucosyl](n) + sucrose = [(1->4)-alpha-D-glucosyl](n+1) + D-fructose"}, {"i": "EC:2.4.1.4", "l": "\"Amylosucrase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33496", "l": "all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate => 3-heptaprenyl-sn-glycero-1-phosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202137", "l": "AKT1 binds eNOS complex via HSP90 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11888", "l": "an aldehyde + H2O + NADP(+) = a carboxylate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57595", "l": "(S)-pinocembrin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-2-hydroxypinocembrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64232", "l": "8 H(+) + holo-[ACP] + 8 malonyl-CoA = atrochrysone carboxyl-[ACP] + 8 CO2 + 8 CoA + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29064", "l": "a menaquinone + formate + H(+) => a menaquinol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936068", "l": "H19 is cleaved to produce miR-675 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-377644", "l": "Release of CSK from SRC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0051003", "l": "ligase activity, forming nitrogen-metal bonds, forming coordination complexes"}, {"i": "EC:6.6.1.-", "l": "\"Forming coordination complexes\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052748", "l": "baicalin beta-D-glucuronidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203613", "l": "depalmitoylation of eNOS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39042", "l": "an omega-oxo fatty acid + H2O + NAD(+) <=> a dicarboxylate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37355", "l": "H2O + uridine 2'-phosphate = phosphate + uridine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51163", "l": "cytidine(60) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(60) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49463", "l": "(2Z,4E)-2-aminomuconate + H2O <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26382", "l": "4-hydroxybutanoate + NADP(+) => H(+) + NADPH + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0039594", "l": "endoribonuclease activity involved in viral induction of host mRNA catabolic process"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2089971", "l": "Secretion of collagens (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626228", "l": "The distal appendage proteins recruit TTBK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20381", "l": "3alpha-hydroxy-5alpha-androstan-17-one + NAD(+) = 5alpha-androstan-3,17-dione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46170", "l": "AMP + diphosphate + pentanoyl-CoA => ATP + CoA + pentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35798", "l": "2'-deamino-2'-hydroxyneamine + UDP-alpha-D-kanosamine <=> H(+) + kanamycin A + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18243", "l": "(2R,5S)-2,5-diaminohexanoate => D-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32496", "l": "(2E)-geraniol + O2 + reduced [NADPH--hemoprotein reductase] => (6E)-8-hydroxygeraniol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57535", "l": "5'-end ribonucleotide-RNA + ATP + H(+) <=> adenosine-5'-diphospho-5'-ribonucleotide-RNA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46599", "l": "NADPH + O2 + rifampicin <=> 2'-N-hydroxyrifampicin + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0008554", "l": "P-type sodium transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54322", "l": "2 [Fe(III)-cytochrome b5] + a Delta(5),Delta(7)-sterol + 2 H2O => 2 [Fe(II)-cytochrome b5] + a Delta(7)-sterol + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11806", "l": "an aromatic carboxylate + 2 H(+) + NADH => an aromatic aldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982810", "l": "JAK2 phosphorylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5679266", "l": "Beclin-1 complex translocates to the ER (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60477", "l": "2 ATP + GTP => cyclic AMP-AMP-GMP + 3 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56543", "l": "(9Z)-octadecenoyl-CoA + 1,2-dihexanoyl-sn-glycerol <=> 1,2-dihexanoyl-3-(9Z-octadecenoyl)-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9677585", "l": "CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33982", "l": "DIBOA beta-D-glucoside + H2O <=> D-glucose + DIBOA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47978", "l": "dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O => dTDP-4-dehydro-6-deoxy-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40875", "l": "(9Z,12Z)-octadecadienoyl-CoA + FAD + H(+) = (2E,9Z,12Z)-octadecatrienoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54505", "l": "all-trans-hexaprenyl diphosphate => beta-hexaprene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12420", "l": "ATP + D-tagatofuranose 6-phosphate = ADP + D-tagatofuranose 1,6-bisphosphate + H(+)"}, {"i": "EC:2.7.1.144", "l": "\"Tagatose-6-phosphate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50229", "l": "FADH2 + O2 + resorcinol => benzene-1,2,4-triol + FAD + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55332", "l": "a 3'-hydroxyflavone + S-adenosyl-L-methionine = a 3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.42", "l": "\"Flavone 3'-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22400", "l": "androstan-3alpha,17beta-diol + NAD(+) = 17beta-hydroxyandrostanone + H(+) + NADH"}, {"i": "RHEA:42004", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH"}, {"i": "EC:1.1.1.53", "l": "\"3-alpha(or 20-beta)-hydroxysteroid dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023845", "l": "ESR1:ESTG binds to proximal and distal regions of the CTSD promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163310", "l": "TFAM binds to mitochondrial promoters (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942224", "l": "Filaggrin binds Keratin tonofilament:Desmosome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877941", "l": "RUNX2 binds SMAD1 in the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156678", "l": "Activation of Cdc25C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417927", "l": "P2Y2 receptor binds ATP and UTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855111", "l": "VLDLR binds PCSK9 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34035", "l": "O2 + paromamine = 6'-oxoparomamine + H2O2"}, {"i": "EC:1.1.3.43", "l": "\"Paromamine 6'-oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67137", "l": "3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + ADP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120283", "l": "protein serine/threonine kinase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198599", "l": "AKT phosphorylates MDM2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427570", "l": "Group 3 - Selective Cl- transport (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420688", "l": "GABAB heterodimeric receptor binds GABA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24234", "l": "3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH => 2-dehydro-3-deoxy-D-gluconate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028598", "l": "Phosphorylation of YAP by LATS1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139893", "l": "Granzyme-B activates BID by cleavage (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55098", "l": "(3S)-3-hydroxypentanoate + CoA + H(+) => (3S)-3-hydroxypentanoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.9", "l": "\"(R)-2-hydroxyacyl-CoA dehydratase activating ATPase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36246", "l": "acetate + NADP(+) + trans-anol <=> NADPH + trans-coumaryl acetate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050223", "l": "protocatechuate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1980125", "l": "ITCH binds DTX (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31725", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10482", "l": "4-hydroxy-2-oxoglutarate + L-glutamate => 2-oxoglutarate + 4-hydroxy-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650447", "l": "SERPING1 variant is not secreted (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682983", "l": "ATM phosphorylates WHSC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30910", "l": "(S)-3-methyl-2-oxopentanoate + CoA + NAD(+) <=> 2-methylbutanoyl-CoA + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60113", "l": "(R)-3-(indol-3-yl)lactoyl-CoA => (E)-3-(indol-3-yl)acryloyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000010", "l": "trans-hexaprenyltranstransferase activity"}, {"i": "RHEA:20836", "l": "all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62278", "l": "6 AMP + beauvericin + 6 diphosphate + 6 H(+) + 3 S-adenosyl-L-homocysteine => 3 (R)-2-hydroxy-3-methylbutyrate + 6 ATP + 3 L-phenylalanine + 3 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36161", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin] => 2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 oxidized 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000031", "l": "mannosylphosphate transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58958", "l": "a 2'-O-methylribonucleotide in RNA + H(+) + S-adenosyl-L-homocysteine => a ribonucleotide in RNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209296", "l": "SU(VAR)2-10 binds to the phosphorylated STAT92E dimer and inhibits transcription (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1362416", "l": "Frataxin binds iron (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607753", "l": "CARD9 oligomerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25736", "l": "L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5674385", "l": "p-T,Y MAPKs dimerize (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48963", "l": "[thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide <=> [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30023", "l": "L-alanine + pyridoxal 5'-phosphate = pyridoxamine 5'-phosphate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50609", "l": "leukotriene B4 + NADP(+) => 12-oxo-leukotriene B4 + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57186", "l": "S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] => L-cysteinyl-[protein] + methylglyoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15172", "l": "H2O + N-succinyl-L-glutamate <=> L-glutamate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009403", "l": "SMURF1 polyubiquitinates RUNX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854052", "l": "Formation of the SCF-FBXL7 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39688", "l": "(R)-3-hydroxy-(11Z)-octadecenoyl-CoA => (2E,11Z)-octadecadienoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57105", "l": "[(1->4)-alpha-D-galacturonosyl](n) => 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-2)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65270", "l": "chrodrimanin F + H2O + NADP(+) => 3-hydroxypentacecilide A + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34581", "l": "2 CO2 + H2O + pentalenolactone F + 2 succinate => 2 2-oxoglutarate + 2 O2 + pentalenolactone D"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674095", "l": "PDGFRs bind type II TKI (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.120"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36003", "l": "(S)-4-hydroxy-2-oxohexanoate = propanal + pyruvate"}, {"i": "EC:4.1.3.43", "l": "\"4-hydroxy-2-oxohexanoate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674531", "l": "AAMP binds EGFR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48588", "l": "2 H2O + 2 leukotriene A4 + O2 = 2 lipoxin B4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158313", "l": "factor XII -> factor XIIa (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64229", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34566", "l": "CDP-alpha-D-abequose + NADP(+) <=> CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295599", "l": "SPRY2 translocates to the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35678", "l": "H(+) + L-serine + tetradecanoyl-CoA <=> 3-oxohexadecasphinganine + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788684", "l": "TRMT13 2'-O-methylates cytidine-4 in tRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.2.-", "l": "\"Hydroxymethyl-, formyl- and related transferases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.21"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17814", "l": "D-altronate + NAD(+) => H(+) + keto-D-tagaturonate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388596", "l": "Melanocortin receptors bind melanocortins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389463", "l": "Proteinase-activated receptors can bind thrombin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65859", "l": "A + a 1-hydroxy-3-oxo steroid <=> a steroid 1,3-dione + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48912", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1a = CMP + ganglioside GT1a + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3781941", "l": "WNTs are secreted in exosomes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25296", "l": "acetate + 2 H(+) + NADH => acetaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047708", "l": "biotinidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047996", "l": "hydroxyphytanate oxidase activity"}, {"i": "KEGG.REACTION:R07151"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635843", "l": "GLI translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13550", "l": "beta-L-fucose 1-phosphate + GTP + H(+) => diphosphate + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380311", "l": "Recruitment of Plk1 to centrosomes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46653", "l": "epitestosterone + H(+) + NADPH => 5beta-dihydroepitestosterone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48211", "l": "H(+) + nonanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168393", "l": "STAT5 association with GHR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-197958", "l": "FPGS-2 transforms THF to THFPG (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25259", "l": "N-acetyl-D-mannosamine 6-phosphate => N-acetyl-D-glucosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2395517", "l": "NADPH transfers electrons to FDXR (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63822", "l": "H(+) + holo-[aryl-carrier protein] + petrobactin => 3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21731", "l": "GDP-alpha-D-mannose + H2O + 2 NAD(+) <=> GDP-alpha-D-mannuronate + 3 H(+) + 2 NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38205", "l": "19-oxo-androst-4-ene-3,17-dione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 19-hydroxyandrost-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004466", "l": "long-chain-acyl-CoA dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004054", "l": "arginine kinase activity"}, {"i": "MetaCyc:ARGININE-KINASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607751", "l": "TRAF6 oligomerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8939203", "l": "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176517", "l": "SULTs transfer (SO4)2- group to PREG (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102829", "l": "ajugose synthase activity"}, {"i": "MetaCyc:RXN-8285"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41819", "l": "ganglioside GD3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GD2 (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54355", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline <=> 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9656891", "l": "OPN1SW binds 11cRAL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19734", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+) => bacteriochlorophyllide a + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395801", "l": "Phosphorylation of LAT by p-SYK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444527", "l": "FPR is a receptor for formyl peptides (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12752", "l": "3,4,5-trihydroxybenzoate + H(+) <=> 1,2,3-trihydroxybenzene + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46721", "l": "(3R)-hydroxyhexanoyl-CoA => (2E)-hexenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004829", "l": "threonine-tRNA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52034", "l": "(+)-7-isojasmonate + L-isoleucine => H2O + L-isoleucine-(+)-7-isojasmonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097383", "l": "dIDP diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15788", "l": "2 6-iminocyclohexa-2,4-dienone + A <=> 2-aminophenoxazin-3-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030340", "l": "hyaluronate lyase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047494", "l": "serine-phosphoethanolamine synthase activity"}, {"i": "RHEA:22656", "l": "CDP-ethanolamine + L-serine = CMP + H(+) + L-serine-phosphoethanolamine"}, {"i": "EC:2.7.8.4", "l": "\"Serine-phosphoethanolamine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706393", "l": "RHOBTB3 binds ATP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809680", "l": "MTMR12 binds MTM1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10009", "l": "[protein]-dithiol + a hydroperoxide => [protein]-disulfide + an alcohol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265177", "l": "Exocyst complex formation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1454928", "l": "ABCG4 may mediate cholesterol efflux (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42698", "l": "NH4(+) + pyruvate + selnoneine thione => H2O + hercynylselenocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19840", "l": "D-sorbitol 6-phosphate + NAD(+) <=> beta-D-fructose 6-phosphate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002113", "l": "interleukin-33 binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047381", "l": "dodecanoyl-[acyl-carrier-protein] hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617217", "l": "Phospho-CREB1 binds the promoter of the CEBPB gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18102", "l": "cis-1,2-dihydro-3-ethylcatechol + NAD(+) => 3-ethylcatechol + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58491", "l": "4-(trimethylamino)butanoate + H(+) + NADH + O2 <=> H2O + NAD(+) + succinate semialdehyde + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49414", "l": "alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP + H(+) => beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-colitose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24171", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52263", "l": "a 7(1),7(1)-dihydroxybacteriochlorophyllide c <=> a bacteriochlorophyllide e + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44666", "l": "a fatty acid + a monoacyl-sn-glycero-3-phosphocholine + H(+) => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31815", "l": "(2E,6E)-farnesyl diphosphate = (+)-beta-caryophyllene + diphosphate"}, {"i": "EC:4.2.3.89", "l": "\"(+)-beta-caryophyllene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54477", "l": "1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + dodecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168166", "l": "NFkB complex is transported from cytosol to nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851866", "l": "MET binds RANBP10 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68610", "l": "Formation of ORC(2-5) complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29401", "l": "diphosphate + H(+) + IMP => H2O + ITP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43600", "l": "3-oxoeicosanoyl-[ACP] + H(+) + NADPH = 3R-hydroxyeicosanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47216", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyestradiol-17beta + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684006", "l": "KPNA2 translocates NBN to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42169", "l": "20alpha-hydroxy-5beta-pregnan-3-one + NADP(+) => 5beta-pregnan-3,20-dione + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-481010", "l": "Surface deployment of platelet dense granule membrane components (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53541", "l": "(13R)-S-cysteinylglycinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O => (13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432010", "l": "Aquaporin-1 passively transports water into cell (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49574", "l": "coproporphyrin III + Fe(2+) => Fe-coproporphyrin III + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20308", "l": "4-hydroxybenzaldehyde + H2O + NAD(+) <=> 4-hydroxybenzoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357831", "l": "CYLD is phosphorylated by IKK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30295", "l": "GTP + pyruvate = GDP + H(+) + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2219524", "l": "PDPK1 binds PIP2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944240", "l": "Association of procollagen type III (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31731", "l": "3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O"}, {"i": "EC:1.14.14.12", "l": "\"3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109700", "l": "AKT2 binds PIP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9724685", "l": "IgE binds omalizumab (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018794", "l": "RHOV binds effectors at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59986", "l": "a carboxylate + L-glutamine => an N(2)-acyl-L-glutamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14094", "l": "2-oxoglutarate + L-tryptophan => indole-3-pyruvate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983194", "l": "Kinesin-1 is a heterotetramer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730842", "l": "PI3K associates with phosphorylated GAB2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43920", "l": "(25R)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25R)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28053", "l": "H2O + NADP(+) <=> NAD(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55868", "l": "(S)-lactate + O2 = H2O2 + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72139", "l": "Formation of the active Spliceosomal C (B*) complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42825", "l": "2 H(+) + 2 NADH + 2 O2 + tetracenomycin A2 => H2O + 2 NAD(+) + tetracenomycin C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33522", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + sphinganine <=> (4R)-hydroxysphinganine + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033989", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity"}, {"i": "REACT:R-HSA-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14754", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] => acetate + androst-4-ene-3,17-dione + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46677", "l": "(4R)-hydroxy-(6R)-2,2,6-trimethylcyclohexanone + NAD(+) => (6R)-2,2,6-trimethyl-1,4-cyclohexanedione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690873", "l": "ACO1 binds 4Fe-4S (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640480", "l": "E2 enzyme UBE2N:UBE2V1 binds ubiquitin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29740", "l": "ATP + beta-maltose(out) + H2O => ADP + beta-maltose(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44835", "l": "(R)-carnitine + tetradecanoyl-CoA <=> CoA + O-tetradecanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10575", "l": "vinylacetyl-CoA <=> (2E)-butenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0018024", "l": "histone-lysine N-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24013", "l": "gamma-tocopherol + S-adenosyl-L-methionine => (+)-alpha-tocopherol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50662", "l": "2-(2-methylsulfanyl)propylmaleate + H2O => 3-(3-methylsulfanyl)propylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10771", "l": "(2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2 <=> (4S)-2,3-dehydroleucopelargonidin + CO2 + H(+) + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797269", "l": "Expression of HSPA8, ALOX15 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31020", "l": "4 AH2 + all-trans-4,4'-diapolycopene + 4 O2 => 4 A + all-trans-4,4'-diapolycopene-4,4'-dial + 6 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10753", "l": "[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n ATP + n D-aspartate => [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n H(+) + n phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114670", "l": "GPIb-IX-V binds to vWF:Collagen complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25597", "l": "5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate"}, {"i": "EC:4.2.99.20", "l": "\"2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357483", "l": "RAC1 binds PAK1-3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18802", "l": "(cis-prenyl)n-diphosphate + isopentenyl diphosphate => (cis-prenyl)(n+1)-diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47330", "l": "(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) => 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12681", "l": "creatinine + H(+) + H2O = N-methylhydantoin + NH4(+)"}, {"i": "EC:3.5.4.21", "l": "\"Creatinine deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16348", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (3E,7E)-dolabella-3,7-dien-18-ol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29433", "l": "ADP + diphosphate => ATP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28058", "l": "L-lyxose = L-xylulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15343", "l": "ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate => ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250220", "l": "Homodimerization of ERBB4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48061", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H2O => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42833", "l": "(2E)-octenal + H(+) + pyruvate => (S)-3-acetyloctanal + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48490", "l": "all-trans-retinal--[retinol-binding protein] + H(+) + NADH => all-trans-retinol--[retinol-binding protein] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427404", "l": "Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28360", "l": "(2E)-tetradecenoyl-CoA + FADH2 => FAD + H(+) + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57253", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP => glycolate + GTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0010354", "l": "homogentisate prenyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604831", "l": "NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.26", "l": "\"Cancer procoagulant\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30118", "l": "decanoyl-[ACP] + H2O <=> decanoate + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62460", "l": "3,4-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] = 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate"}, {"i": "EC:6.2.1.62", "l": "\"3,4-dihydroxybenzoate--[aryl-carrier protein] ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22627", "l": "(S)-4-hydroxy-2-oxopentanoate <=> acetaldehyde + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013109", "l": "RHOC GEFs activate RHOC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48228", "l": "a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 1-lyso-glycerophospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]"}, {"i": "EC:2.3.1.269", "l": "\"Apolipoprotein N-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8948136", "l": "ULK1 Translocates to the mitochondria (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55068", "l": "a 12-oxojasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] = a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140439", "l": "protein-cysteine S-stearoyltransferase activity"}, {"i": "RHEA:59740", "l": "L-cysteinyl-[protein] + octadecanoyl-CoA = CoA + S-octadecanoyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25836", "l": "3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O = 5-deoxy-D-glucuronate + H(+)"}, {"i": "EC:3.7.1.22", "l": "\"3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (decyclizing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41841", "l": "3-oxooctanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyoctanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210921", "l": "NEUROG3-dependent synthesis of NKX2-2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9733969", "l": "Bile salts dissociate from FABP6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42096", "l": "ATP + carbamoyl phosphate + H2O + tobramycin = AMP + diphosphate + H(+) + nebramycin 5' + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34739", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine = H(+) + N-acyl-15-methylhexadecasphing-4-enine + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53888", "l": "D-glucose 6-phosphate + TDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + H(+) + TDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33595", "l": "(4R)-hydroxysphinganine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166721", "l": "MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163810", "l": "GGCX gamma-carboxylates GAS6(31-691) (pro-GAS6) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46191", "l": "an aliphatic nitrile + 2 H2O <=> a carboxylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5633460", "l": "MDM2 binds TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222594", "l": "Mycothiol scavenges nitrosyl (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44879", "l": "a 1,3-diacylglycerol + H2O <=> 3-acyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52488", "l": "O2 + prostaglandin E2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy prostaglandin E2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53903", "l": "ATP + L-threonyl-[myosin light chain] <=> ADP + H(+) + O-phospho-L-threonyl-[myosin light chain]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48665", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 12,20-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57479", "l": "dodecanoate + H2O2 <=> 2-hydroxydodecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30975", "l": "15-cis-phytoene + 5 A = 5 AH2 + all-trans-3,4-didehydrolycopene"}, {"i": "EC:1.3.99.30", "l": "\"Phytoene desaturase (3,4-didehydrolycopene-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855189", "l": "I(1,4,5,6)P4 transports from the ER lumen to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40901", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663165", "l": "p-BMAL1:p-CLOCK,NPAS2 binds AVP gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38615", "l": "cyclic ADP-ribose + H2O = ADP-D-ribose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9737780", "l": "MTTP binds lomitapide (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12704", "l": "[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-triphosphate + H2O <=> [thioredoxin]-dithiol + a ribonucleoside 5'-triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36413", "l": "calciol => cholesta-5,7-dien-3beta-ol + hnu"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39275", "l": "(2E,15Z)-tetracosadienoyl-CoA + H(+) + NADPH = (15Z)-tetracosenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202703", "l": "CD47 binds SIRP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20075", "l": "acetaldehyde + glycine => D-allothreonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46087", "l": "H2O + sn-glycerol 1-phosphate <=> glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63229", "l": "ATP + spectinomycin => 9-O-adenylylspectinomycin + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37250", "l": "H2O + thymidine 3'-monophosphate <=> phosphate + thymidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33342", "l": "(4R)-hydroxysphinganine + hexacosanoyl-CoA <=> CoA + H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51742", "l": "a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58142", "l": "AMP + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) => acetyl-AMP + cytidine(34) in elongator tRNA(Met)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-112434", "l": "Formation of DSIF complex  (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419861", "l": "Melanospin is stimulated by light (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40902", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62781", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36931", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (9Z)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.7.-", "l": "\"With an iron-sulfur protein as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27290", "l": "A + formate + H(+) = AH2 + CO2"}, {"i": "EC:1.17.98.4", "l": "\"Formate dehydrogenase (acceptor)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450550", "l": "PKCalpha phosphorylates HuR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13274", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol => 6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48403", "l": "2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 <=> CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55566", "l": "4-hydoxytryptamine 4-phosphate + ADP + H(+) => 4-hydroxytryptamine + ATP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008147", "l": "structural constituent of bone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20399", "l": "H(+) + L,L-cystathionine + succinate => L-cysteine + O-succinyl-L-homoserine"}]}
{"type": "biolink:MolecularActivity", "ic": "64.67771801809657", "identifiers": [{"i": "GO:0016782", "l": "transferase activity, transferring sulphur-containing groups"}, {"i": "EC:2.8.-.-", "l": "\"Transferring sulfur-containing groups\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209891", "l": "Dopamine is oxidised to noradrenaline (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814094", "l": "ARL1:GTP binds ARFIP2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31080", "l": "3-hydroxyisovaleryl-CoA => 3-methyl-(2E)-butenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350410", "l": "RHO1:GDP complex dissociates from RHOGAPP190 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28777", "l": "H(+) + H2O + hnu + oxidized dinoflagellate luciferin => dinoflagellate luciferin + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65352", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177920", "l": "Binding of GRB2 to GAB1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2984226", "l": "PLK1 phosphorylates NEK9 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53892", "l": "an S-prenyl-L-cysteine + H2O + O2 = a prenal + H2O2 + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50350", "l": "dolichyl diphosphate + H(+) + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74734", "l": "Re-integration of insulin receptor into plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3857336", "l": "CEBPB homodimerization (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21251", "l": "a ribonucleoside 5'-triphosphate + RNA(n) <=> diphosphate + RNA(n+1)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.85", "l": "\"Limulus clotting factor B\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9660557", "l": "RAS:GTP binds RAL GDS proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24541", "l": "A + D-glucose => AH2 + D-glucono-1,5-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159868", "l": "Furin cleaves pro-factor VII to factor VII (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28545", "l": "fluoroacetyl-CoA + H2O <=> CoA + fluoroacetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54785", "l": "Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide => Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30956", "l": "9,9'-di-cis-zeta-carotene + 2 a quinone => 7,7',9,9'-tetra-cis-lycopene + 2 a quinol"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0034324", "l": "O-hexanoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41734", "l": "[(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate => [(1->4)-alpha-D-glucosyl](n) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0043047", "l": "single-stranded telomeric DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12573", "l": "(R)-1-aminopropan-2-ol + adenosylcob(III)yrate + ATP => adenosylcob(III)inamide + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647977", "l": "ICMT methylates S-Farn RAS proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27286", "l": "(S)-acetoin + NAD(+) = diacetyl + H(+) + NADH"}, {"i": "EC:1.1.1.304", "l": "\"Diacetyl reductase ((S)-acetoin forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13459", "l": "[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysine + CO2 => 3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N(6)-lipoyl-L-lysine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32214", "l": "(Z)-5-oxohex-2-enedioate <=> (2E,4Z)-2-hydroxyhexa-2,4-dienedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29862", "l": "5'-deoxyadenosine + H2O <=> 5-deoxy-D-ribose + adenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65612", "l": "a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 21-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28919", "l": "4-aminobutanoate(in) + L-glutamate(out) = 4-aminobutanoate(out) + L-glutamate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050279", "l": "sepiapterin deaminase activity"}, {"i": "RHEA:14025", "l": "H(+) + H2O + sepiapterin = NH4(+) + xanthopterin-B2"}, {"i": "EC:3.5.4.24", "l": "\"Sepiapterin deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9010815", "l": "SLITs bind keratan sulfate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944232", "l": "Association of procollagen type XII (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-606287", "l": "RSF complex binds the centromere (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34784", "l": "a 3alpha-hydroxysteroid + NADP(+) => a 3-oxosteroid + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990648", "l": "inositol-4,5,6-triphosphate 5-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47874", "l": "ganglioside GA1 + N-acetylneuraminate => ganglioside GM1 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909732", "l": "Phosphorylation of STAT2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3159259", "l": "MMAA:MUT binds AdoCbl (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5656070", "l": "FGFBPs bind FGFs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20768", "l": "3-phosphonopyruvate + H(+) = CO2 + phosphonoacetaldehyde"}, {"i": "EC:4.1.1.82", "l": "\"Phosphonopyruvate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1299338", "l": "Activation of TRESK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64613", "l": "ATP + L-glutamate + tRNA(Gln) => AMP + diphosphate + L-glutamyl-tRNA(Gln)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23301", "l": "(2E)-geranyl diphosphate + isopentenyl diphosphate => (2Z,6E)-farnesyl diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685906", "l": "Polyadenylation of SARS-CoV-1 subgenomic mRNAs (plus strand) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "80.661393760018115", "identifiers": [{"i": "GO:0005343", "l": "organic acid:sodium symporter activity"}, {"i": "REACT:R-HSA-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432129", "l": "FGR binds and phosphorylates LRP8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12949", "l": "D-fuconate = 2-dehydro-3-deoxy-D-fuconate + H2O"}, {"i": "EC:4.2.1.67", "l": "\"D-fuconate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000007", "l": "low-affinity zinc ion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70573", "l": "argininosuccinate <=> fumarate + arginine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373073", "l": "Receptors CCR1, 2 and 8 bind CCL16 ligand (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0004954", "l": "prostanoid receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59198", "l": "AMP + H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] => holo-[(phenol)carboxyphthiodiolenone synthase] + icosanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052662", "l": "zeaxanthin epoxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788707", "l": "TRMT44 2'-O-methylates uridine-44 in tRNA(Ser) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40454", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62769", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2470508", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60805", "l": "2-oxoglutarate + gibberellin A19 + O2 => CO2 + gibberellin A17 + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034009", "l": "isoprene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296043", "l": "Activation of HCN channels (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247844", "l": "WNT ligands traffic to the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52189", "l": "1-aci-nitro-2-(1H-indol-3-yl)ethane + glutathione => (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-354173", "l": "Activation of Rap1 by cytosolic GEFs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047240", "l": "lactosylceramide beta-1,3-galactosyltransferase activity"}, {"i": "RHEA:18413", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosaminyl derivative + H(+) + UDP"}, {"i": "EC:2.4.1.179", "l": "\"Lactosylceramide beta-1,3-galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805981", "l": "HMGB1 release from cells (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376149", "l": "Proteolytic processing of SLIT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693111", "l": "RHOF auto-activates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876472", "l": "NPC2 binds CHOL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204773", "l": "Interaction of Tie2 and Grb7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46598", "l": "2'-N-hydroxyrifampicin + H2O + NADP(+) => NADPH + O2 + rifampicin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672951", "l": "Inactive RAFs bind YWHAB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046982", "l": "protein heterodimerization activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445705", "l": "Release Of ADP From Myosin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3640862", "l": "Tankyrase binds AXIN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56318", "l": "3-acetylamino-4-hydroxybenzoate + CoA => 3-amino-4-hydroxybenzoate + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848316", "l": "IL36 binds IL1RL2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57461", "l": "(E)-sinapoyl alcohol + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-trans-4-sinapoyl alcohol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50674", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose => [(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49115", "l": "phenazine-1-carboxylate + S-adenosyl-L-methionine <=> 5-methyl-phenazine-1-carboxylate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389491", "l": "Two NPFF receptors can bind neuropeptide FF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44423", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O <=> a 1-acyl-sn-glycero-3-phosphate + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25511", "l": "(2E)-geranyl diphosphate <=> (1S,5S)-sabinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0005042", "l": "netrin receptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004711", "l": "ribosomal protein S6 kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59988", "l": "cyclohexane-1-carbonyl-CoA + NADP(+) = cyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH"}, {"i": "EC:1.3.1.120", "l": "\"Cyclohexane-1-carbonyl-CoA reductase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37394", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z)-octadecaenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684351", "l": "pp1a cleaves itself (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29202", "l": "(S)-dihydroorotate + menaquinone-8 <=> menaquinol-8 + orotate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809010", "l": "COPI vesicle uncoating (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44800", "l": "1,4-dihydroxy-2-naphthoate + all-trans-hexaprenyl diphosphate + H(+) = 2-demethylmenaquinol-6 + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62869", "l": "9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + NADPH + O2 => H2O + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54080", "l": "5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine = 5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51527", "l": "(S)-corytuberine + S-adenosyl-L-methionine <=> magnoflorine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018490", "l": "4-hydroxyphenylpyruvate oxidase activity"}, {"i": "MetaCyc:1.2.3.13-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-203973", "l": "Vesicle budding (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53314", "l": "16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17631", "l": "alpha,alpha-trehalose(out) => alpha,alpha-trehalose(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13243", "l": "ADP + beta-L-fucose 1-phosphate + H(+) => ATP + L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52727", "l": "3'-phosphoadenylyl sulfate + an aliphatic desulfo-glucosinolate <=> adenosine 3',5'-bisphosphate + an omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18010", "l": "glutaryl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-glutaryl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026366", "l": "NTF3-bound NTRK2 dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62860", "l": "acetyl-CoA + 7 H(+) + 7 malonyl-CoA = 7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + 7 CO2 + 8 CoA + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47470", "l": "(3E,5Z)-tetradecadienoyl-CoA => (2E,4E)-tetradecadienoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029270", "l": "Recruitment of PLCgamma to membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034923", "l": "phenanthrene-4,5-dicarboxylate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036175", "l": "ribonucleoside-diphosphate reductase activity, glutaredoxin disulfide as acceptor"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56250", "l": "2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein] => 1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797766", "l": "TP53 binds the BIRC5 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27297", "l": "D-glucose 6-phosphate + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) <=> 6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13133", "l": "CTP + di-trans,poly-cis-dolichol = CDP + dolichyl phosphate + H(+)"}, {"i": "EC:2.7.1.108", "l": "\"Dolichol kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30492", "l": "L-valine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31733", "l": "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O => 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49997", "l": "cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9649733", "l": "mature p21 RAS binds GDP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12409", "l": "L-lysine + NAD(+) => 2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35169", "l": "minocycline(out) => minocycline(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12871", "l": "(4S)-limonene + diphosphate => (2E)-geranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902122", "l": "chenodeoxycholic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853762", "l": "RET dimerizes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106322", "l": "S-(hydroxymethyl)glutathione dehydrogenase NAD activity"}, {"i": "RHEA:19981", "l": "NADP(+) + S-(hydroxymethyl)glutathione = H(+) + NADPH + S-formylglutathione"}, {"i": "RHEA:19985", "l": "NAD(+) + S-(hydroxymethyl)glutathione = H(+) + NADH + S-formylglutathione"}, {"i": "EC:1.1.1.284", "l": "\"S-(hydroxymethyl)glutathione dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20262", "l": "3,5,7-trioxododecanoyl-CoA => CO2 + CoA + olivetol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983194", "l": "Kinesin-1 is a heterotetramer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53423", "l": "8-demethyl-8-(methylamino)riboflavin + S-adenosyl-L-methionine <=> H(+) + roseoflavin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654571", "l": "Activated FGFR1 binds FRS3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.74", "l": "\"Fragilysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22249", "l": "7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) => 7,8-dihydroxykynurenate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691167", "l": "CUL1, SKP1, FBXL5 bind (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448421", "l": "Interleukin-27 translocates from the ER lumen to the extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38712", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecylglycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13006", "l": "(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine => H(+) + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55430", "l": "11-hydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ferruginol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16830", "l": "an aldehyde + H2O + O2 => a carboxylate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48923", "l": "ADP + bacteriochlorophyllide g + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate <=> 3,8-divinyl chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.39", "l": "\"Deuterolysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47926", "l": "(S)-3-sulfolactaldehyde + pyruvate => 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4720473", "l": "Defective ALG3 does not add mannose to the N-glycan precursor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55729", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] => 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42295", "l": "a fatty acyl-[ACP] + phosphate <=> an acyl phosphate + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114683", "l": "Phosphorylation of Platelet Sec-1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0019707", "l": "protein-cysteine S-acyltransferase activity"}, {"i": "RHEA:63372", "l": "an acyl-CoA + L-cysteinyl-[protein] = an S-acyl-L-cysteinyl-[protein] + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008430", "l": "selenium binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033233", "l": "PEX5S,L binds cargo proteins containing PTS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015558", "l": "secondary active p-aminobenzoyl-glutamate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688834", "l": "ATXN3 binds VCP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228508", "l": "RANBP2 SUMOylates PML with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39166", "l": "3-oxohexadecanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxyhexadecanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163625", "l": "Glucagon binds to Glucagon receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49243", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) <=> L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043825", "l": "succinylornithine transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29224", "l": "menaquinone-8 + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + menaquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64773", "l": "S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine => 2-aminoprop-2-enoate + 2-methyl-3-sulfanylbutan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57088", "l": "an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O = 3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66730", "l": "ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate(out) + phosphate => ATP + H2O + N-acetyl-L-aspartyl-L-glutamate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65354", "l": "12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H2O => 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34110", "l": "glycine + H(+) + hexadecanoyl-CoA <=> 1-deoxymethyl-3-dehydrosphinganine + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050341", "l": "thymine dioxygenase activity"}, {"i": "RHEA:10316", "l": "2-oxoglutarate + O2 + thymine = 5-hydroxymethyluracil + CO2 + succinate"}, {"i": "EC:1.14.11.6", "l": "\"Thymine dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69053", "l": "RFC binding displaces Pol Alpha (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39132", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57197", "l": "H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] => glycolate + H(+) + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-196017", "l": "Dynamin is recruited to the gap junction plaque (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26172", "l": "1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = CoA + H(+) + mycothiol"}, {"i": "EC:2.3.1.189", "l": "\"Mycothiol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10256", "l": "[(1->4)-6-phospho-alpha-D-glucosyl](n) + n ATP + n H2O = [(1->4)-3,6-bisphospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate"}, {"i": "EC:2.7.9.5", "l": "\"Phosphoglucan, water dikinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018756", "l": "RHOH binds GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43929", "l": "pregn-5-ene-3,20-dione => progesterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.99.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36794", "l": "H2O + N(omega)-hydroxy-L-arginine <=> hydroxyurea + L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10593", "l": "a 3',5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] => a 3'-hydroxy,5'-unsubstituted flavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53548", "l": "prostaglandin J2 = Delta(12)-prostaglandin J2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55016", "l": "H(+) + menthone + NADPH + O2 = 7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20947", "l": "S-adenosyl-L-methionine + theobromine <=> caffeine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2889070", "l": "SLC9B2 exchanges Na+, Li+ for H+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114558", "l": "Thrombin-activated PARs activate Gq (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28457", "l": "N(6)-(D-fructosyl)-L-lysine(in) <=> N(6)-(D-fructosyl)-L-lysine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9671145", "l": "DKC1 binds SHQ1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21735", "l": "chorismate + L-glutamine <=> anthranilate + H(+) + L-glutamate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2106625", "l": "Duplex siRNA is loaded into Argonaute (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0000293", "l": "ferric-chelate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50245", "l": "17alpha-hydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxyandrost-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2002466", "l": "Formation of allysine by LOX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682388", "l": "Autophagosome maturation (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34120", "l": "3 H(+) + hexanoyl-CoA + 3 malonyl-CoA => 3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186765", "l": "PLC-gamma binds to the active receptor (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374919", "l": "Noradrenaline clearance from the synaptic cleft (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161948", "l": "Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24755", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + primary fluorescent chlorophyll catabolite <=> 3 H(+) + red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9611839", "l": "β3-agonists bind ADRB3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21699", "l": "N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36805", "l": "genistein + H(+) + H2O => 2-hydroxy-2,3-dihydrogenistein"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65082", "l": "asperaculane E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => asperaculane D + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061595", "l": "6-deoxy-6-sulfofructose-1-phosphate aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19200", "l": "adenosine 5'-phosphosulfate + NH4(+) <=> adenosine 5'-phosphoramidate + 2 H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56306", "l": "21-phosphorifampicin + AMP + 2 H(+) + phosphate => ATP + H2O + rifampicin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044585", "l": "cellobiose binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34009", "l": "ergosta-5,7,24(28)-trien-3beta-ol + H(+) + S-adenosyl-L-homocysteine => cholesta-5,7,24-trien-3beta-ol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008712", "l": "ADP-glyceromanno-heptose 6-epimerase activity"}, {"i": "RHEA:17577", "l": "ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D-manno-heptose"}, {"i": "EC:5.1.3.20", "l": "\"ADP-glyceromanno-heptose 6-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27464", "l": "D-glycero-alpha-D-manno-heptose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-D-glycero-alpha-D-manno-heptose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51744", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A = a 1,2-diacyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41971", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) <=> a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32338", "l": "(1S,2S,4R)-endo-fenchol + NADP(+) <=> (1S,4R)-fenchone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35089", "l": "D-glucosamine + N-acetyl-D-glucosamine 6-phosphate => H2O + N'-monoacetylchitobiose-6'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416562", "l": "p190RhoGAP binds Plexin-B1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373087", "l": "Receptor CCR6 binds CCL20 ligand (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44688", "l": "a 2-acylglycerol + H2O = a fatty acid + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35681", "l": "3-oxotetradecasphinganine + CO2 + CoA => dodecanoyl-CoA + H(+) + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417896", "l": "P2Y6 receptor can bind to UDP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58256", "l": "H2O + O-(ADP-D-ribosyl)-L-seryl-[protein] = ADP-D-ribose + L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58636", "l": "N-(9Z-octadecenoyl)-(2S)-hydroxyglycine = (9Z)-octadecenamide + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19395", "l": "(S)-2-amino-6-oxohexanoate + L-alanine => L-lysine + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10368", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose = dTDP-4-dehydro-6-deoxy-D-galactose + L-glutamate"}, {"i": "EC:2.6.1.59", "l": "\"dTDP-4-amino-4,6-dideoxygalactose transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49434", "l": "choloyl-CoA + lithocholate => cholate + lithocholoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39902", "l": "7-deoxyloganetin + UDP-alpha-D-glucose <=> 7-deoxyloganin + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "71.944304668973928", "identifiers": [{"i": "GO:0016776", "l": "phosphotransferase activity, phosphate group as acceptor"}, {"i": "EC:2.7.4.-", "l": "\"Phosphotransferases with a phosphate group as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30683", "l": "H2O + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N-acetyl-D-mannosamine + UDP"}, {"i": "EC:3.2.1.183", "l": "\"UDP-N-acetylglucosamine 2-epimerase (hydrolyzing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9627104", "l": "XIAP binds CASP3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38144", "l": "carbon disulfide + 2 H2O => CO2 + 2 H(+) + 2 hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9619376", "l": "CAMK1 binds calmodulin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849094", "l": "ARHGAP35 binds RASA1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40408", "l": "1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP => 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-383190", "l": "HCO3- transport through ion channel (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381446", "l": "Thrombin proteolyzes IGF:IGFBP3:ALS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53141", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3132759", "l": "TCN1 binds Cbl (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29387", "l": "CTP + H2O = CDP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655825", "l": "SREBP1A,1C,2:SCAP binds CopII Coat Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849435", "l": "PTPN1 dephosphorylates PTK6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174255", "l": "Degradation multiubiquitinated Cyclin A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60890", "l": "(N(7)-methyl 5'-triphospho-guanosine)-guanosine + a 5'-end phospho-ribonucleoside in mRNA + H(+) => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine-phospho-ribonucleoside in mRNA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "46.678513772297947", "identifiers": [{"i": "GO:0016787", "l": "hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912364", "l": "MIR181C microRNA binds 3'UTR of NOTCH4 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46666", "l": "5beta-dihydrocorticosterone + NADP(+) => corticosterone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016707", "l": "gibberellin 3-beta-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31963", "l": "9beta-pimara-7,15-dien-19-al + O2 + reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-dien-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033831", "l": "kojibiose phosphorylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592316", "l": "Initial activation of proMMP1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57054", "l": "CO2 + L-erythrulose => 3-oxoisoapionate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43612", "l": "S-adenosyl-L-methionine + uridine(341) in tmRNA = 5-methyluridine(341) in tmRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2328048", "l": "Emilin is found in elastic fibres (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388828", "l": "PD-1 binds B7DC and B7H1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035730", "l": "S-nitrosoglutathione binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50103", "l": "dodecanoyl-CoA + taurine <=> CoA + H(+) + N-dodecanoyl-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62326", "l": "(+)-malbrancheamide + FADH2 => (+)-malbrancheamide B + chloride + FAD + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64301", "l": "3-phenylpropylamine + pyruvate => 3-phenylpropanal + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53938", "l": "19-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25505", "l": "(2E)-geranyl diphosphate => beta-phellandrene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375141", "l": "Neogenin:Netrin-3 binds CDO complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59502", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate => 5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35157", "l": "(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one => (S)-4,5-dihydroxypentane-2,3-dione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34279", "l": "di-trans,poly-cis-dolichol + NADP(+) = di-trans,cis-polyprenol + H(+) + NADPH"}, {"i": "EC:1.3.1.94", "l": "\"Polyprenol reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61599", "l": "[DsbD protein]-dithiol + [thioredoxin]-disulfide <=> [DsbD protein]-disulfide + [thioredoxin]-dithiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009488", "l": "IL34 binds CSF1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.71", "l": "\"Glucan endo-1,2-beta-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32887", "l": "all-trans-beta-carotene + O2 = 2 all-trans-retinal"}, {"i": "EC:1.13.11.63", "l": "\"Beta-carotene 15,15'-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168459", "l": "Lyn activates ERK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32935", "l": "a cardiolipin + H2O = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632412", "l": "PTK2 is recruited to methylated ESR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672948", "l": "MARK3 phosphorylates KSR1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30765", "l": "3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+) => H2O + L-valine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008755", "l": "O antigen polymerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32908", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + 2 H2O => 2 a carboxylate + 2 H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678694", "l": "Heparanase 2 (HPSE2) cleaves heparan sulfate from its proteoglycan (plasma membrane) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.7", "l": "\"Glutamyl aminopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40793", "l": "CoA + H(+) + hexacosanoate => H2O + hexacosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48586", "l": "2 lipoxin A4 => 2 H2O + 2 leukotriene A4 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.117", "l": "\"D-arabinose 1-dehydrogenase (NAD(P)(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17194", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043212", "l": "carbohydrate-exporting ABC transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050535", "l": "beta-primeverosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047775", "l": "citramalate CoA-transferase activity"}, {"i": "MetaCyc:CITRAMALATE-COA-TRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36535", "l": "docosanoyl-CoA + sphinganine = CoA + H(+) + N-docosanoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106344", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity from histidine and PLP"}, {"i": "RHEA:65756", "l": "2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] = (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374701", "l": "Phosphorylation of DCC by Fyn (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700171", "l": "Active ALK phosphorylates PLCG1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202222", "l": "Phosphorylation of PKC theta (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022396", "l": "MME:Zn2+ hydrolyses AGT(34-43) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084505", "l": "Laminins bind HSPG2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875568", "l": "RAPGEF1 activates RAP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56155", "l": "(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine <=> (9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45803", "l": "15-demethylaclacinomycin T + AH2 + O2 <=> 10-decarboxymethylaclacinomycin T + A + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043899", "l": "phosphoserine:homoserine phosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24968", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = H2O + 2 oxidized [adrenodoxin] + secalciferol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28092", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857686", "l": "FITM1, FITM2 bind TAGs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28000", "l": "H(+) + phosphate + thiamine phosphate => H2O + thiamine diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60685", "l": "(11R)-dihydroartemisinic aldehyde + H2O + NADP(+) => (11R)-dihydroartemisinate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36520", "l": "H(+) + hexacosanoyl-CoA + malonyl-CoA => 3-oxooctacosanyol-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41985", "l": "NAD(+) + propan-2-ol => acetone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41190", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785895", "l": "Expression of IL4, IL13-upregulated extracellular proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14873", "l": "indole-3-ethanol + NAD(+) = H(+) + indole-3-acetaldehyde + NADH"}, {"i": "EC:1.1.1.190", "l": "\"Indole-3-acetaldehyde reductase (NADH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34196", "l": "2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 2 H(+) + O2 => 2 aureusidin 6-O-beta-glucoside + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65417", "l": "dGMP(in) + NAD(+)(out) => dGMP(out) + NAD(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65498", "l": "3beta,20alpha-dihydroxy-5beta-pregnane + NADP(+) => 3beta-hydroxy-5beta-pregnane-20-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55796", "l": "H(+) + NADH + O2 + phenol = H2O + hydroquinone + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031878", "l": "type 1 somatostatin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45760", "l": "dTDP-beta-L-daunosamine + epsilon-rhodomycinone = dTDP + H(+) + rhodomycin D"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26533", "l": "4-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047940", "l": "glucuronokinase activity"}, {"i": "KEGG.REACTION:R01476"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635892", "l": "ATF4 binds the ATF3 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54944", "l": "3-oxo-(5Z)-dodecenoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-(5Z)-dodecenoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033975", "l": "(R)-2-haloacid dehalogenase activity"}, {"i": "RHEA:22188", "l": "an (R)-2-haloacid + H2O = a (2S)-2-hydroxycarboxylate + a halide anion + H(+)"}, {"i": "MetaCyc:3.8.1.9-RXN"}, {"i": "EC:3.8.1.9", "l": "\"(R)-2-haloacid dehalogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25013", "l": "H(+) + N,N-dihydroxy-L-tryptophan = (E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42959", "l": "cytidine(38) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.7.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39657", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + A + 2 H2O => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35394", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA <=> (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443439", "l": "c-Src binds Raf1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17767", "l": "(2R)-2,3-bisphosphoglycerate + H(+) => (2R)-3-phospho-glyceroyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618093", "l": "ATP hydrolysis by HSP90 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15111", "l": "(4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH => 2-dehydro-3-deoxy-D-gluconate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351901", "l": "Caspase-mediated cleavage of MST3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "68.86768025975131", "identifiers": [{"i": "GO:0008528", "l": "G protein-coupled peptide receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201629", "l": "Caspase-mediated cleavage of Tau (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29520", "l": "alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008887", "l": "glycerate kinase activity"}, {"i": "MetaCyc:GLY3KIN-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6801666", "l": "PLK2 phosphorylates CENPJ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31326", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP-alpha-D-mannose <=> (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34945", "l": "arbutin 6-phosphate(in) + pyruvate(in) => hydroquinone O-beta-D-glucopyranoside(out) + phosphoenolpyruvate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32756", "l": "(2S)-naringenin + 2-oxoglutarate + O2 => apigenin + CO2 + H(+) + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25122", "l": "(S)-2-amino-6-oxohexanoate => H(+) + H2O + L-1-piperideine-6-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35526", "l": "H(+) + N-ethylmaleimide + NADPH <=> N-ethylsuccinimide + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444705", "l": "T1R1/T1R3 dimer is the umami taste receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53420", "l": "8-demethyl-8-(methylamino)riboflavin + S-adenosyl-L-methionine = H(+) + roseoflavin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182990", "l": "Sprouty sequesters CBL away from active EGFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1297275", "l": "CD9:Izumo Binding (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990050", "l": "phosphatidic acid transfer activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034576", "l": "N-isopropylacetanilide amidohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106358", "l": "glycerol-1-phosphate dehydrogenase [NADP+] activity"}, {"i": "RHEA:21416", "l": "NADP(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62439", "l": "L-lyxonate <=> 2-dehydro-3-deoxy-L-arabinonate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54620", "l": "2-oxoglutarate + eicosanoyl-CoA + O2 = 2-hydroxyeicosanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9696271", "l": "RND1 binds effectors (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46348", "l": "(2E)-octenoyl-CoA + H2O = 3-hydroxyoctanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5688797", "l": "ATXN3 family cleave Ub chains (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9009072", "l": "STAT3 phosphorylation (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45805", "l": "ATP + hydroxylamine + L-glutamate => ADP + L-glutamine hydroxamate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28080", "l": "H(+) + NADH + phosphonoacetaldehyde => 2-hydroxyethylphosphonate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41114", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862184", "l": "USP48 cleaves polyubiquitin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14858", "l": "(indol-3-yl)acetate + ATP + L-lysine => ADP + H(+) + N(6)-[(indole-3-yl)acetyl]-L-lysine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655278", "l": "Activated FGFR1 mutants phosphorylate FRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56202", "l": "H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781922", "l": "USP13 binds UFD1L:SKP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047508", "l": "(R)-2-methylmalate dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46906", "l": "a 1,2-diacyl-sn-glycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A hexaacyl 1-(2-aminoethyl diphosphate)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51933", "l": "2 [Fe(III)-cytochrome c3] + hydrogen sulfide + sulfite => 2 [Fe(II)-cytochrome c3] + thiosulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43410", "l": "beta-D-galactosyl-(1<->1')-sphinganine + H(+) + UDP => sphinganine + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24596", "l": "acetyl-CoA + L-histidine = CoA + H(+) + N(alpha)-acetyl-L-histidine"}, {"i": "EC:2.3.1.33", "l": "\"Histidine N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29809", "l": "ADP + H(+) + L-leucine(in) + phosphate => ATP + H2O + L-leucine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50503", "l": "acetyl-CoA + N-terminal L-alanyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40781", "l": "L-2-aminopentanoate + NH4(+) => 2-aminopentanenitrile + H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16154", "l": "an aliphatic amine + H2O + O2 => an aldehyde + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40242", "l": "ATP + CoA + dodecanedioate <=> AMP + diphosphate + dodecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728747", "l": "GNAT3 exchanges GDP for GTP in TAS2R:bitter compound:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11651", "l": "(-)-menthol + H(+) + NADPH + O2 <=> 1,4-menthane-3,8-diol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32266", "l": "4-aminobutanoate + pyruvate <=> L-alanine + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27857", "l": "(2E)-geranyl diphosphate + 4-hydroxybenzoate <=> 3-geranyl-4-hydroxybenzoate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38556", "l": "an all-trans-retinyl ester + H2O => a fatty acid + all-trans-retinol + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047673", "l": "anthranilate N-malonyltransferase activity"}, {"i": "RHEA:17557", "l": "anthranilate + malonyl-CoA = CoA + N-malonylanthranilate"}, {"i": "EC:2.3.1.113", "l": "\"Anthranilate N-malonyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.12"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44984", "l": "(R)-carnitine + 3-methylbutanoyl-CoA = CoA + O-3-methylbutanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46686", "l": "(22E)-3-oxo-chol-4,22-dien-24-oyl-CoA + AH2 => 3-oxochol-4-en-24-oyl-CoA + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676598", "l": "TRAF2:cIAP1/2 complex binds FN14:TWEAK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928615", "l": "EFNBs bind SFKs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0008401", "l": "retinoic acid 4-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36345", "l": "2-methylsulfanyl-N(6)-(cis-4-hydroxy-Delta(2)-isopentenyl)adenosine in tRNA + H2O + NADP(+) => 2-methylsulfanyl-N(6)-(Delta(2)-isopentenyl)adenosine in tRNA + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41659", "l": "dihydrosanguinarine + NADP(+) <=> NADPH + sanguinarine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43674", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45136", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate = 7,8-dihydroneopterin 3'-phosphate + H2O"}, {"i": "EC:4.2.1.160", "l": "\"2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140081", "l": "glycosylated region protein binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033857", "l": "diphosphoinositol-pentakisphosphate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46067", "l": "(11E)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (6Z,11E)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696274", "l": "RND1 binds GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948775", "l": "MKRN1 polyubiquitinates PTEN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-165195", "l": "GTP loading by Rheb (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112429", "l": "Formation of FACT complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55127", "l": "(2E)-5-methylhexenoyl-[ACP] + H(+) + NADH <=> 5-methylhexanoyl-[ACP] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10234", "l": "5,6-dihydrouracil + 5-phospho-alpha-D-ribose 1-diphosphate => 5,6-dihydrouridine 5'-monophosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411365", "l": "Transcription of canonical WNT targets is negatively regulated by NLK-dependent phosphorylation of TCF/LEF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40398", "l": "1,2-dihydro-beta-NAD + H(+) + O2 <=> H2O2 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625904", "l": "Hypochlorous acid (HOCL) reacts with Lys residue to form Lys-monochloramine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21659", "l": "CDP-alpha-D-paratose <=> CDP-3,6-dideoxy-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58643", "l": "a 5'-(5'-phospho)-ribonucleoside-RNA + 2 S-adenosyl-L-methionine <=> a 5'-(5'-bisphosphomethyl)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134962", "l": "DHX36 binds DNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189069", "l": "sucrose + H2O => glucose + fructose (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67081", "l": "a very long-chain fatty acid(in) + ATP + H2O => a very long-chain fatty acid(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.21", "l": "\"Aspartate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13480", "l": "H2O + L-tryptophan + NADP(+) <=> H(+) + indole-3-pyruvate + NADPH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684882", "l": "CHEK1 is recruited to resected DNA DSBs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193068", "l": "CYP17A1 17-hydroxylates PREG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57509", "l": "H2O + NADP(+) + staphylopine => (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32581", "l": "(1R,5R)-beta-pinene + diphosphate => (2E)-geranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24488", "l": "H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77077", "l": "Capping complex formation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035236", "l": "proctolin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676229", "l": "WIPIs bind PI3P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030793", "l": "3'-demethylstaurosporine O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211247", "l": "Cleavage of DNA by DFF40 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102393", "l": "decanoyl-[acp] 2-dehydrogenase activity"}, {"i": "MetaCyc:RXN-13624"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.12"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426209", "l": "DAG activation of TRPC channels (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51310", "l": "H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+) => H(+) + L-methionyl-[F-actin] + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418856", "l": "Activation of Rac1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38149", "l": "carbonyl sulfide + H(+) + hydrogen sulfide => carbon disulfide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32634", "l": "erythromycin D + H(+) + NADPH + O2 <=> erythromycin C + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38325", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + glycerol => 2 1-(9Z-octadecenoyl)-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14933", "l": "H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] = N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54278", "l": "(3S)-3-hydroxy-L-aspartyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-aspartyl-[protein] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417890", "l": "P2Y5 receptor can bind to LPA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33269", "l": "2 (S)-2-amino-6-oxoheptanedioate + NADPH + NH4(+) => (S)-2,3,4,5-tetrahydrodipicolinate + 2 H2O + meso-2,6-diaminoheptanedioate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.99.8", "l": "\"Capsanthin/capsorubin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27458", "l": "3-iodo-L-tyrosine + iodide + NADP(+) => 3,5-diiodo-L-tyrosine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38941", "l": "diosgenin 3-O-beta-D-glucoside + 2 L-rhamnopyranose => dioscin + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936995", "l": "THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58703", "l": "FADH2-C4alpha-hydroperoxide + NADPH + rifampicin <=> FADH2 + H(+) + H2O + NADP(+) + rifampicin hemiaminal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32422", "l": "(1S,2R,4R)-neoisodihydrocarveol + NAD(+) <=> (1S,4R)-isodihydrocarvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701488", "l": "Active ALK phosphorylates JAK3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055077", "l": "gap junction hemi-channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44693", "l": "a fatty acyl-CoA + hexadecasphinganine => CoA + H(+) + N-acylhexadecasphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875661", "l": "GGA3 associates with activated MET receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20882", "l": "10-oxodecanoate + H(+) + NADH => 10-hydroxydecanoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65799", "l": "fenuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62261", "l": "2 hydrogencarbonate(out) + Mn(2+)(out) => 2 hydrogencarbonate(in) + Mn(2+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-376886", "l": "Efflux of glucose and orthophosphate from the endoplasmic reticulum (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698013", "l": "PTPN11:p-STAT5 dissociates from mutant FLT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204873", "l": "Interaction of Tie2 and Shp2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203973", "l": "Vesicle budding (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65304", "l": "2-oxoglutarate + O2 + verruculide A = chrodrimanin T + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928627", "l": "EPHB phosphorylates TIAM1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66225", "l": "asc-C9-CoA + O2 => asc-DeltaC9-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51300", "l": "(9Z)-octadecenoate + L-phenylalanine = H2O + N-(9Z-octadecenoyl)-L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31394", "l": "15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+) <=> all-trans-4,4'-diapolycopene + 4 FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43394", "l": "1D-myo-inositol 1,3-bisphosphate + phosphate => 1D-myo-inositol 1,3,4-trisphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209272", "l": "N-HH binds to the transmembrane HSPG proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031493", "l": "nucleosomal histone binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203977", "l": "SAR1 Activation And Membrane Binding (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24364", "l": "H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD(+) = 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042498", "l": "diacyl lipopeptide binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050455", "l": "columbamine oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53719", "l": "H(+) + N-acetyl-alpha-D-muramate 1-phosphate + UDP <=> phosphate + UDP-N-acetyl-alpha-D-muramate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851298", "l": "GPR143 binds L-Dopa (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.2.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66548", "l": "3'-phosphoadenylyl sulfate + 4-nitrophenol = 4-nitrophenyl sulfate + adenosine 3',5'-bisphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016158", "l": "3-phytase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008658", "l": "penicillin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18840", "l": "10-deacetyltaxuyunnanin C + acetyl-CoA <=> CoA + taxuyunnanin C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33405", "l": "diphosphate + L-threonyl-5'-AMP => ATP + L-threonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42377", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203700", "l": "eNOS translocation from Golgi to Caveolae (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33974", "l": "5''-phosphoribostamycin + H2O <=> phosphate + ribostamycin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167459", "l": "Abortive  termination of HIV-1 elongation after arrest (Tat-containing elongation complex) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878257", "l": "RUNX2 binds the IHH gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428625", "l": "Vesicular inhibitory amino acid transport (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35173", "l": "H(+)(in) + novobiocin(out) => H(+)(out) + novobiocin(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645428", "l": "ALPK1 binds ADP-heptose (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030215", "l": "semaphorin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51907", "l": "10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate <=> 10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49944", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate = (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052686", "l": "perillic acid-CoA ligase (AMP-forming) activity"}, {"i": "KEGG.REACTION:R06368"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005114", "l": "type II transforming growth factor beta receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9654533", "l": "KRAS4B recycles to the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.23", "l": "\"PepB aminopeptidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008706", "l": "6-phospho-beta-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018794", "l": "2-hydroxyisobutyrate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48427", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dUMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654571", "l": "Activated FGFR1 binds FRS3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20953", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose => beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51961", "l": "(Z)-2-methylpropanal oxime => 2-methylpropanenitrile + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045480", "l": "galactose oxidase activity"}, {"i": "RHEA:24160", "l": "D-galactose + O2 = D-galacto-hexodialdose + H2O2"}, {"i": "EC:1.1.3.9", "l": "\"Galactose oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44582", "l": "2-all-trans-decaprenylphenol + CO2 => 4-hydroxy-3-all-trans-decaprenylbenzoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.7.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29910", "l": "H2O + sn-glycero-3-phospho-(1'-rac-glycerol) <=> glycerol + H(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16406", "l": "benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) => benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48544", "l": "[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.233", "l": "\"[Phosphatase 2A protein]-leucine-carboxy methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38922", "l": "H2O + sphing-4-enine-phosphocholine <=> choline + H(+) + sphing-4-enine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38279", "l": "(3R)-citramalate + succinyl-CoA = (3R)-citramalyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19492", "l": "dibenzothiophene 5,5-dioxide + FMNH2 + O2 <=> 2'-hydroxybiphenyl-2-sulfinate + FMN-N(5)-oxide + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432143", "l": "PECAM-1 binds PP2A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16297", "l": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH"}, {"i": "EC:1.1.1.210", "l": "\"3-beta-(or 20-alpha)-hydroxysteroid dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018674", "l": "(S)-limonene 3-monooxygenase activity"}, {"i": "RHEA:15129", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,6R)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.99", "l": "\"(S)-limonene 3-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18984", "l": "(R)-pantolactone + NADP(+) <=> 2-dehydropantolactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032567", "l": "dGTP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707690", "l": "BACH1 binds MAFK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39216", "l": "(2E)-hexacosenoyl-CoA + H(+) + NADPH => hexacosanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31185", "l": "3-oxododecanoyl-CoA + CoA => acetyl-CoA + decanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50185", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 => N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102335", "l": "N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44005", "l": "3-methyl fatty acid + ATP + CoA => a 3-methyl fatty acyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018768", "l": "RHOU auto-activates (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64053", "l": "(13Z)-docosenoyl-CoA + (4R)-hydroxysphinganine => CoA + H(+) + N-(13Z-docosenoyl)-4R-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016980", "l": "creatinase activity"}, {"i": "RHEA:22456", "l": "creatine + H2O = sarcosine + urea"}, {"i": "EC:3.5.3.3", "l": "\"Creatinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3296301", "l": "CCRL2 binds CCL19 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50427", "l": "(8Z,11Z,14Z)-eicosatrienoate + 2 O2 <=> prostaglandin G1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804100", "l": "HMGB1 binds LPS (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27302", "l": "7-chloro-L-tryptophan + O2 = 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52166", "l": "(R)-mandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + phenylacetonitrile + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045521", "l": "interleukin-25 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350408", "l": "PK binds to VANG at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57422", "l": "H(+) + NAD(+) + 2 reduced [cytochrome P450] => NADH + 2 oxidized [cytochrome P450]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39197", "l": "(3R)-hydroxytetracosanoyl-CoA + NADP(+) => 3-oxotetracosanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186785", "l": "RNF111 ubiquitinates SMAD7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51924", "l": "AH2 + menaquinone-9 = A + beta-dihydromenaquinone-9"}, {"i": "EC:1.3.99.38", "l": "\"Menaquinone-9-beta-reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018522", "l": "benzoyl-CoA reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18369", "l": "O2 + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H2O2"}, {"i": "EC:1.1.3.21", "l": "\"Glycerol-3-phosphate oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45451", "l": "H2O + N-(dodecanoyl)-sphinganine <=> dodecanoate + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30436", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + glycyl-tRNA(Gly) => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + tRNA(Gly)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56520", "l": "Fe-coproporphyrin III + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + 2 CO2 + heme b + 2 L-methionine"}, {"i": "EC:1.3.98.6", "l": "\"AdoMet-dependent heme synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51642", "l": "(11R)-hydroperoxy-(9Z,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647977", "l": "ICMT methylates S-Farn RAS proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005026", "l": "transforming growth factor beta receptor activity, type II"}, {"i": "REACT:R-HSA-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40663", "l": "L-serine = 2-aminoprop-2-enoate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000100", "l": "S-methylmethionine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36810", "l": "H(+) + malonyl-CoA + octacosanoyl-CoA <=> 3-oxo-triacontanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419426", "l": "Cannabinoid receptors can bind cannabinoids (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21185", "l": "dolichyl phosphate + GDP-alpha-D-mannose => dolichyl beta-D-mannosyl phosphate + GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28932", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate => 4-carboxy-2-hydroxy-cis,cis-muconate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55219", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + rhizathalene A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848110", "l": "SOCS3 binds activated PTK6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1006143", "l": "CD46 binds C3b (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38191", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone = 17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693575", "l": "DNA-PKcs autophosphorylates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45867", "l": "16-hydroxyhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12665", "l": "a 2-deoxystreptamine antibiotic + acetyl-CoA = an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)"}, {"i": "EC:2.3.1.81", "l": "\"Aminoglycoside N(3)-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19822", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21852", "l": "(R)-10-hydroxyoctadecanoate = (9Z)-octadecenoate + H2O"}, {"i": "EC:4.2.1.53", "l": "\"Oleate hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004869", "l": "cysteine-type endopeptidase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50957", "l": "cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine => H(+) + N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050048", "l": "L-leucine:2-oxoglutarate aminotransferase activity"}, {"i": "MetaCyc:LEUCINE-AMINOTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55997", "l": "H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] => beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199144", "l": "Nectin 2 binds CD226 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38439", "l": "(9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38569", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191303", "l": "FDPS dimer transfers IPPP to GPP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41107", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404134", "l": "RBP4:atROL binds TTR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5660662", "l": "ASC binds Caspase-8 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41290", "l": "H2O + N-tetradecanoylsphing-4-enine <=> sphing-4-enine + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15522", "l": "N-terminal glycyl-[protein] + tetradecanoyl-CoA => CoA + H(+) + N-tetradecanoylglycyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.7", "l": "\"Heparin lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.53", "l": "\"Calpain-2\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687097", "l": "p-S857 NCOA3 binds ETV4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781905", "l": "ZRANB1 binds APC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013006", "l": "RHOA:GTP translocates to the ER membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432129", "l": "FGR binds and phosphorylates LRP8 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20538", "l": "H2O + holo-[ACP] => apo-[ACP] + D-pantetheine 4'-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65479", "l": "1-propanol + butanoyl-CoA <=> CoA + propyl butanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022065", "l": "DSPGs are secreted (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34884", "l": "ATP + H2O + selenate(out) => ADP + H(+) + phosphate + selenate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003934", "l": "GTP cyclohydrolase I activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051008", "l": "Hsp27 protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008312", "l": "7S RNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389862", "l": "Conversion of glyoxylate to oxalate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016992", "l": "lipoate synthase activity"}, {"i": "REACT:R-HSA-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30978", "l": "15-cis-phytoene + 5 A <=> 5 AH2 + all-trans-3,4-didehydrolycopene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24268", "l": "2,6-dioxo-6-phenylhexanoate + NADP(+) = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH"}, {"i": "EC:1.3.1.40", "l": "\"2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40221", "l": "CoA + H(+) + malonate => H2O + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373741", "l": "SDK2 homophillic interaction (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59994", "l": "(E)-4-coumarate + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + phloretate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18703", "l": "arsenate + 3 H(+) + 2 reduced [azurin] => arsenite + H2O + 2 oxidized [azurin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730856", "l": "Autophosphorylation of PAK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25737", "l": "2 H(+) + H2O + N-hydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase] => L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53475", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805470", "l": "AMPK phosphorylates TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-182986", "l": "CBL-mediated ubiquitination of CIN85 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23519", "l": "(R)-glycerate + ATP <=> (2R)-3-phosphoglycerate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46973", "l": "A + dihydrobisanhydrobacterioruberin => AH2 + bisanhydrobacterioruberin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162191", "l": "DMPhOH is hydroxylated to MDMQ10H2 by DMPhOH monooxygenase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49946", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25166", "l": "(2E)-butenoyl-CoA + AH2 => A + butanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55586", "l": "H(+) + N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine => adenosine in mRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22234", "l": "diphosphate + NADP(+) + squalene => H(+) + NADPH + presqualene diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001068", "l": "transcription regulatory region RNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62502", "l": "AMP + H(+) + L-arginyl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-arginyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42332", "l": "ATP + L-glutamate + oxidized coenzyme F420-2 = ADP + H(+) + oxidized coenzyme alpha-F420-3 + phosphate"}, {"i": "EC:6.3.2.32", "l": "\"Coenzyme gamma-F420-2:alpha-L-glutamate ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51911", "l": "dATP + H2O <=> dADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24921", "l": "2-aminobut-2-enoate + H2O => L-homoserine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27627", "l": "D-erythrose 4-phosphate + D-xylulose 5-phosphate => beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45473", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44022", "l": "2 H(+) + NADH + octadecanoate => H2O + NAD(+) + octadecanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15583", "l": "biochanin A 7-O-beta-D-glucoside 6''-O-malonate + CoA => biochanin A 7-O-beta-D-glucoside + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202721", "l": "JAM2 binds JAM3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12668", "l": "a 2-deoxystreptamine antibiotic + acetyl-CoA <=> an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033878", "l": "hormone-sensitive lipase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13405", "l": "4-coumaroyl-CoA + agmatine = CoA + H(+) + N-(4-guanidinobutyl)-4-hydroxycinnamamide"}, {"i": "EC:2.3.1.64", "l": "\"Agmatine N(4)-coumaroyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "75.848614326174683", "identifiers": [{"i": "GO:0016893", "l": "endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters"}, {"i": "EC:3.1.30.-", "l": "\"Endoribonucleases active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37891", "l": "aclacinomycin T + H2O = 15-demethylaclacinomycin T + methanol"}, {"i": "EC:3.1.1.95", "l": "\"Aclacinomycin methylesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54733", "l": "N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062068", "l": "chloroplast photosystem II binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61873", "l": "1-O-methyl-(9Z,12Z)-octadecadienoate + O2 => 1-O-methyl-(9R)-hydroperoxy-(10E,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18440", "l": "4-CDP-2-C-methyl-D-erythritol + ATP <=> 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16563", "l": "hopan-22-ol => H2O + squalene"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004454", "l": "ketohexokinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56874", "l": "(S)-1-phenylethylamine + acetate => (S)-N-acetyl-1-phenylethylamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205244", "l": "Recruitment of CBL to KIT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654159", "l": "Activated FGFR2 binds PLCG1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63190", "l": "A + H2O + norbelladine => 3,4-dihydroxybenzaldehyde + AH2 + tyramine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3204311", "l": "AOX1 oxidises PXL to PDXate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602466", "l": "Activation of MT-MMPs by FURIN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26242", "l": "geranylgeranyl diphosphate => diphosphate + elisabethatriene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375144", "l": "Interaction of NCAM1:GFRalpha-1 with GDNF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869558", "l": "HSPD1 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198458", "l": "Efflux of glucose from the endoplasmic reticulum (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39100", "l": "3-oxodecanedioyl-CoA + CoA => acetyl-CoA + octanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103027", "l": "FMN phosphatase activity"}, {"i": "MetaCyc:RXN0-5187"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21052", "l": "(2S)-2-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH"}, {"i": "EC:1.1.1.269", "l": "\"2-(S)-hydroxypropyl-CoM dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14258", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670014", "l": "Factor VIIIa dissociates  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38643", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357445", "l": "PAK1-3 dimer disassociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5579084", "l": "Defective AHCY does not hydrolyse AdoHcy (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55720", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] = 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17238", "l": "ATP + FMN + H(+) => diphosphate + FAD"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46267", "l": "2 [Fe(II)-cytochrome b5] + an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44089", "l": "ATP + CoA + heptanoate => AMP + diphosphate + heptanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54347", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66577", "l": "3'-phosphoadenylyl sulfate + 4-isopropylphenol => 4-isopropylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26499", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose => delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43161", "l": "adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.154"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54566", "l": "a 5'-phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+) => 5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016710", "l": "trans-cinnamate 4-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61432", "l": "(R)-8-oxocitronellyl enol + NADP(+) = (6E)-8-oxogeranial + H(+) + NADPH"}, {"i": "EC:1.3.1.123", "l": "\"7-epi-iridoid synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57181", "l": "L-lysyl-[protein] + methylglyoxal => N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008754", "l": "O antigen ligase activity"}, {"i": "MetaCyc:RXN0-5294"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14266", "l": "(S)-4-amino-5-oxopentanoate => 5-aminolevulinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419157", "l": "5'-phosphoribosylformylglycinamidine (FGAM) + ATP => 5'-phosphoribosyl-5-aminoimidazole (AIR) + ADP + orthophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031997", "l": "N-terminal myristoylation domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000327", "l": "PLK1 phosphorylates BORA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696482", "l": "CTF1 binds LIFR:JAKs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694462", "l": "ABHD6,12 hydrolyse 3AG (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18649", "l": "D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12487", "l": "a ribonucleoside 5'-phosphate + H2O <=> a ribonucleoside + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59943", "l": "2-methyloctadecanoyl-CoA + H2O <=> 2-methyloctadecanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24469", "l": "H(+) + N,N-dimethylaniline + NADPH + O2 => H2O + N,N-dimethylaniline N-oxide + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168848", "l": "tBID binds to inactive BAK protein (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52125", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.18"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59344", "l": "D-maltose + O2 = D-maltobiono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782943", "l": "UV-DDB ubiquitinates XPC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15413", "l": "(2R,3R)-tartrate = H2O + oxaloacetate"}, {"i": "EC:4.2.1.32", "l": "\"L(+)-tartrate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53596", "l": "1-octadecanoyl-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12236", "l": "H2O + NADP(+) + nicotinate = 6-hydroxynicotinate + H(+) + NADPH"}, {"i": "EC:1.17.1.5", "l": "\"Nicotinate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55448", "l": "a 3',5'-unsubstituted flavanone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = a 3',5'-dihydroxyflavanone + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.81", "l": "\"Flavonoid 3',5'-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195378", "l": "Homodimerization of VEGF proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12545", "l": "2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine => 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936380", "l": "Interaction of PIN1 with p-IRF3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23457", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 => A + crepenynate + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11898", "l": "7alpha-hydroxycholest-4-en-3-one + H(+) + NADH => 7alpha-hydroxycholesterol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16282", "l": "ATP + dihydrostreptomycin 6-phosphate => ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69005", "l": "Cdc6 protein is phosphorylated by CDK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58175", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> beta-pinacene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37317", "l": "glycine + L-glutamine => glycyl-L-glutamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26309", "l": "1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA + H(+)"}, {"i": "EC:3.1.2.28", "l": "\"1,4-dihydroxy-2-naphthoyl-CoA hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624272", "l": "MMPs cleave HB-EGF (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65055", "l": "4-(trifluoromethyl)benzyl alcohol + NAD(+) <=> 4-(trifluoromethyl)benzaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54709", "l": "N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004375", "l": "glycine dehydrogenase (decarboxylating) activity"}, {"i": "RHEA:24304", "l": "glycine + H(+) + N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2"}, {"i": "EC:1.4.4.2", "l": "\"Glycine dehydrogenase (aminomethyl-transferring)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102111", "l": "gibberellin A20,2-oxoglutarate:oxygen oxidoreductase activity"}, {"i": "MetaCyc:RXN-113"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950183", "l": "IL12B binds IL23A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199062", "l": "KLRC1:KLRD1 heterodimer interacts with HLA-E (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709831", "l": "HSP90 binds TBK1 and IRF3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11954", "l": "2-hydroxy-3-oxopropanoate => 3-hydroxypyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9006850", "l": "IL21 receptor JAK phosphorylation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9604767", "l": "FLT3LG dimer:FLT3 dimer autophosphorylates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847977", "l": "FRK phosphorylates PTEN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62714", "l": "H2O + NADP(+) + stemphyloxin I => betaenone C + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20275", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46259", "l": "2 [Fe(II)-cytochrome b5] + a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44021", "l": "H2O + NAD(+) + octadecanal => 2 H(+) + NADH + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12357", "l": "D-mannose 6-phosphate => D-fructose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35739", "l": "cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin] = 4-methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone"}, {"i": "EC:1.14.15.6", "l": "\"Cholesterol monooxygenase (side-chain-cleaving)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052605", "l": "gamma-tocopherol cyclase activity"}, {"i": "RHEA:37983", "l": "gamma-tocopherol = 2,3-dimethyl-6-phytylbenzene-1,4-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605736", "l": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008694", "l": "IL37, IL37(?-218) translocates from cytosol to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13976", "l": "diphosphate + H(+)(in) + H2O <=> 2 H(+)(out) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0046624", "l": "sphingolipid transporter activity"}, {"i": "REACT:R-HSA-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41025", "l": "1-O-hexadecyl-2-acetyl-3-octadecanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432148", "l": "Fgr may phosphorylate p38 MAPK (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003735", "l": "structural constituent of ribosome"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694082", "l": "XK:KEL:Zn2+ cleaves EDN3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16702", "l": "17alpha-estradiol + NAD(+) => estrone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9022314", "l": "HIPK2 phosphorylates MECP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0051021", "l": "GDP-dissociation inhibitor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59890", "l": "A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+) => 4-chloro-L-lysine + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35619", "l": "L-idarate = D-glucarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678981", "l": "TLR9 processing at neutral pH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507873", "l": "Aquaporins passively transport urea out of cells (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052847", "l": "inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity"}, {"i": "MetaCyc:RXN-10975"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14133", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = 16-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.103", "l": "\"Tabersonine 16-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29777", "l": "ADP + alpha-D-ribose 1,5-bisphosphate + H(+) => alpha-D-ribose 1-phosphate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62813", "l": "4 monapinone A + O2 => 2 dinapinone A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17389", "l": "D-arabinitol + NAD(+) = D-ribulose + H(+) + NADH"}, {"i": "EC:1.1.1.250", "l": "\"D-arabinitol 2-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380586", "l": "loading of Serotonin in synaptic vesicles (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42830", "l": "2,7-dihydroxy-5-methyl-1-naphthoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-hydroxy-5-methyl-1-naphthoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050161", "l": "succinyl-CoA:oxalate CoA-transferase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373074", "l": "Receptor CCR9  binds CCL25 ligand (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54185", "l": "an N-acyl-aromatic L-alpha-amino acid + H2O => a carboxylate + an aromatic L-alpha-amino acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74723", "l": "Endosome acidification (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106223", "l": "germacrene A hydroxylase activity"}, {"i": "RHEA:30303", "l": "(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.95", "l": "\"Germacrene A hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610723", "l": "GLI proteins bind SUFU (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.25"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41826", "l": "(3R)-hydroxyhexanoyl-[ACP] + NADP(+) => 3-oxohexanoyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424482", "l": "p85 regulatory unit of PI3K binds p-6Y-SYK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61189", "l": "quercetin 3-O-beta-D-glucoside + UDP-beta-L-rhamnose => H(+) + quercetin 3-O-beta-D-glucoside-7-O-alpha-L-rhamnoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52447", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose <=> 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12858", "l": "(2S,3S)-3-methyl-L-aspartate => L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981931", "l": "RAC1 and CDC42 activate PAK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199050", "l": "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49734", "l": "CO2 + H2O + violacein => H(+) + O2 + violaceinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045131", "l": "pre-mRNA branch point binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21363", "l": "ATP + beta-nicotinamide D-ribonucleotide + H(+) <=> diphosphate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47962", "l": "L-histidyl-[protein] + phosphate => H2O + N(tele)-phospho-L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25157", "l": "(R)-4'-phosphopantothenate + ATP + L-cysteine => AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68960", "l": "DNA polymerase epsilon binds at the origin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0005160", "l": "transforming growth factor beta receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050166", "l": "pantoate 4-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1912379", "l": "Transport of fringe-modified NOTCH to plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62005", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc6S derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc6S derivative + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296309", "l": "HCAR3 binds HCAR3 ligands (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19996", "l": "[thioredoxin]-disulfide + H2O + L-methionine <=> [thioredoxin]-dithiol + L-methionine (S)-S-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62295", "l": "(S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) <=> 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24878", "l": "A + L-sorbopyranose = 1-dehydro-L-sorbose + AH2"}, {"i": "EC:1.1.99.32", "l": "\"L-sorbose 1-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685597", "l": "RTC binds SARS-CoV-1 genomic RNA complement (minus strand) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30635", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate = alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}, {"i": "EC:2.4.1.267", "l": "\"Dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112054", "l": "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865994", "l": "GAB1 binds PTPN11 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48593", "l": "a quinone + formate + H(+) => a quinol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42776", "l": "adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.180", "l": "\"16S rRNA (adenine(1408)-N(1))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57918", "l": "4-phosphooxy-L-aspartyl-tRNA(Asn) + ADP + H(+) => ATP + L-aspartyl-tRNA(Asn)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11353", "l": "acetate + ATP => acetyl phosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54879", "l": "(4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one <=> (3S)-3-isopropenyl-6-oxoheptanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32384", "l": "(1S,2S,4R)-limonene-1,2-diol + NAD(+) => (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004968", "l": "gonadotropin-releasing hormone receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32062", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + H2O <=> (R)-glycerate + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59792", "l": "H2O + NADP(+) + yersinopine = (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13504", "l": "ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] <=> ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664867", "l": "NBR1 binds MAP1LC3B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-181567", "l": "botC LC cleaves target cell STX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13122", "l": "ATP + shikimate => 3-phosphoshikimate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000824", "l": "inositol tetrakisphosphate 3-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20168", "l": "H2O + N(5)-acyl-L-ornithine ester <=> an alcohol + H(+) + N(5)-acyl-L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17966", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + H(+) => (8Z,11Z,14Z)-heptadecatrienal + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14924", "l": "(indol-3-yl)acetate + UDP-alpha-D-glucose <=> 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050319", "l": "tartrate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29716", "l": "2-hydroxyethane-1-sulfonate + FMNH2 + O2 => FMN + glycolaldehyde + 2 H(+) + H2O + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30162", "l": "germacra-1(10),4,11(13)-trien-12-ol + NADP(+) <=> germacra-1(10),4,11(13)-trien-12-al + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37699", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22700", "l": "gibberellin A12 aldehyde + O2 + reduced [NADPH--hemoprotein reductase] = gibberellin A12 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14233", "l": "a 2-acyl-sn-glycerol 3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA"}, {"i": "EC:2.3.1.52", "l": "\"2-acylglycerol-3-phosphate O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30890", "l": "4-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin <=> 7,8-dihydropteroate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399952", "l": "Phosphorylation of LIMK-1 by PAK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033904", "l": "dextranase activity"}, {"i": "MetaCyc:3.2.1.11-RXN"}, {"i": "EC:3.2.1.11", "l": "\"Dextranase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662608", "l": "MT2A binds cadmium (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28557", "l": "D-mannose 6-phosphate + H2O <=> D-mannose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374337", "l": "Apelin receptor binds to apelin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3965450", "l": "DAAM1 recruits PFN1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205118", "l": "TRAF6 polyubiquitinates NRIF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58723", "l": "(S)-nicotine + NADPH + O2 <=> H2O + NADP(+) + trans-(S)-nicotine N(1')-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49026", "l": "2-iminio-3-(indol-3-yl)propanoate + H2O2 => L-tryptophan + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63887", "l": "H2O2 + L-tyrosine <=> H2O + L-dopa"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044653", "l": "dextrin alpha-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12734", "l": "CO2 + diphosphate + nicotinate beta-D-ribonucleotide => 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103062", "l": "cis-keto-C60-meroacyl-AMP ligase activity"}, {"i": "MetaCyc:RXN1G-4142"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44011", "l": "2-methyl-branched fatty aldehyde + H2O + NAD(+) <=> 2-methyl fatty acid + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55953", "l": "an inositol-1-phosphoceramide + GDP-alpha-D-mannose => a mannosylinositol-1-phospho-N-acyl-sphingoid base + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62675", "l": "a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine <=> an N(6)-methyl-2'-O-methyladenosine in U2 snRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21323", "l": "A + D-sorbitol <=> AH2 + keto-L-sorbose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985943", "l": "p-Y701-STAT1 dimerizes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55387", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate <=> 6 diphosphate + tetra-trans,hexa-cis-undecaprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54105", "l": "N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877361", "l": "Pyrin binds ASC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42491", "l": "(3R)-3-amino-3-phenylpropanoyl-CoA + baccatin III <=> 3'-N-debenzoyl-2'-deoxytaxol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683765", "l": "Nucleoprotein translocates to the ERGIC outer membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111879", "l": "PIP2 hydrolysis (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66105", "l": "3-(4-hydroxyphenyl)pyruvate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21519", "l": "isopiperitenone <=> piperitenone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24258", "l": "ADP + H(+) + kanamycin 3'-phosphate => ATP + kanamycin A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450466", "l": "AUF1:mRNA complex is destroyed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19567", "l": "diphosphate + sabinene hydrate => (2E)-geranyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787820", "l": "IL34 dimer binds CSF1R (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17550", "l": "1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine => 1-acyl-2-(10-methylene)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13989", "l": "alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose"}, {"i": "EC:2.7.7.12", "l": "\"UDP-glucose--hexose-1-phosphate uridylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54017", "l": "(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607043", "l": "factor VIIIa associates with cell membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45091", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33813", "l": "6 AMP + corynebactin + 6 diphosphate + 3 H(+) + 3 H2O => 3 2,3-dihydroxybenzoate + 6 ATP + 3 glycine + 3 L-threonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209823", "l": "Tyrosine is hydroxylated to dopa (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005128", "l": "erythropoietin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671702", "l": "AP1G2 binds HGS and CHMP2A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40199", "l": "hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983421", "l": "Journey of cargo through Golgi complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028724", "l": "AMOT proteins bind YAP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44164", "l": "ATP + H2O = adenine + D-ribose 5-triphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034549", "l": "N-cyclopropylammelide alkylamino hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102842", "l": "1-18:1-2-16:2-monogalactosyldiacylglycerol desaturase activity (SN2-16:3 forming)"}, {"i": "RHEA:46412", "l": "a (7Z,10Z)-hexadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a (7Z,10Z,13Z)-hexadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030786", "l": "(RS)-norcoclaurine 6-O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32897", "l": "2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58849", "l": "(6E)-8-hydroxygeraniol + NAD(+) => (6E)-8-hydroxygeranial + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15969", "l": "2 glutathione + H(+) + methylarsonate = glutathione disulfide + H2O + methylarsonous acid"}, {"i": "EC:1.20.4.2", "l": "\"Methylarsonate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34774", "l": "a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) <=> a 3-oxosteroid + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32561", "l": "diphosphate + gamma-terpinene => (2E)-geranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9687625", "l": "ATP binds MLKL (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27473", "l": "ATP + D-glycero-beta-D-manno-heptose 7-phosphate = ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+)"}, {"i": "EC:2.7.1.167", "l": "\"D-glycero-beta-D-manno-heptose-7-phosphate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11871", "l": "D-arabinitol + NADP(+) <=> D-ribulose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62420", "l": "a (R)-2-hydroxy fatty acid + O2 = a fatty acid + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12869", "l": "(2E)-geranyl diphosphate = (4S)-limonene + diphosphate"}, {"i": "EC:4.2.3.16", "l": "\"(4S)-limonene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13234", "l": "guanosine + phosphate => alpha-D-ribose 1-phosphate + guanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676591", "l": "2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62389", "l": "[(1->2)-beta-D-glucosyl](n) + H2O => [(1->2)-beta-D-glucosyl](n-2) + sophorose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30942", "l": "ATP + dIDP <=> ADP + dITP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102546", "l": "mannosylglycerate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42751", "l": "cytidine(967) in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12736", "l": "CO2 + diphosphate + nicotinate beta-D-ribonucleotide <=> 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34943", "l": "hydroquinone O-beta-D-glucopyranoside(out) + phosphoenolpyruvate(in) = arbutin 6-phosphate(in) + pyruvate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37738", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine <=> 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16247", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043992", "l": "histone acetyltransferase activity (H3-K9 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41963", "l": "ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose <=> ganglioside GA1 (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51884", "l": "L-proline betaine = D-proline betaine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48416", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)) = CMP + ganglioside GM2 (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0031078", "l": "histone deacetylase activity (H3-K14 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31974", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + NADPH + O2 <=> 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23987", "l": "cholesterol + NADP(+) <=> cholesta-5,7-dien-3beta-ol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070679", "l": "inositol 1,4,5 trisphosphate binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1900995", "l": "ubiquinone-6 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3266566", "l": "G6PC2 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (islet) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15742", "l": "2,5-dichlorocyclohexa-2,5-dien-1,4-diol + NAD(+) => 2,5-dichlorohydroquinone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64688", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45233", "l": "a (2E,4Z)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(2E)-enoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36500", "l": "2-dehydro-3-deoxy-L-rhamnonate + NAD(+) => 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49381", "l": "5-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 5,20-dihydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39426", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA <=> (2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41253", "l": "7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoate => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32713", "l": "a 3-oxoacyl-CoA + H(+) + NADH => a (3R)-3-hydroxyacyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614816", "l": "Latent Transcriptinally Repressed HCMV Genome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42667", "l": "L-arabinofuranose + NADP(+) <=> H(+) + L-arabinono-1,4-lactone + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63412", "l": "2,4,6-trichlorophenol + FADH2 + O2 = 2,6-dichlorobenzoquinone + chloride + FAD + H(+) + H2O"}, {"i": "RHEA:63416", "l": "2,6-dichlorohydroquinone + FADH2 + O2 = 2-chloro-6-hydroxy-1,4-benzoquinone + chloride + FAD + 2 H(+) + H2O"}, {"i": "EC:1.14.14.173", "l": "\"2,4,6-trichlorophenol monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592398", "l": "Activation of proMMP8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63216", "l": "7-cyano-7-carbaguanosine(15) in tRNA + L-lysine = 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19168", "l": "a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose <=> 1,2-diacyl-3-O-[alpha-D-glucosyl-(1-> 2)-alpha-D-glucosyl]-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653957", "l": "Rag dimer formation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21995", "l": "acetyl-CoA + L-lysyl-[histone] <=> CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40666", "l": "L-serine <=> 2-aminoprop-2-enoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44801", "l": "1,4-dihydroxy-2-naphthoate + all-trans-hexaprenyl diphosphate + H(+) => 2-demethylmenaquinol-6 + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190261", "l": "FGFR3c binds to FGF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21827", "l": "2-oxoglutarate + L-aspartate <=> L-glutamate + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114683", "l": "Phosphorylation of Platelet Sec-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029473", "l": "Branching and elongation of mother and daughter filaments (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5627775", "l": "Autophosphorylation of PAK1,2,3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983424", "l": "Budding of COPII coated vesicle (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33596", "l": "(4R)-hydroxysphinganine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804741", "l": "MDM2 forms homo- or heterodimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029270", "l": "Recruitment of PLCgamma to membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39229", "l": "NADP(+) + octacosanoyl-CoA => (2E)-octacosenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48170", "l": "N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine + N-acetylneuraminate => H2O + N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791285", "l": "TP53 binds the BID gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51755", "l": "a 2-acylphloroglucinol + dimethylallyl diphosphate <=> a 2-acyl-4-prenylphloroglucinol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36646", "l": "emodin + S-adenosyl-L-methionine <=> H(+) + questin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50144", "l": "ethyl (9Z)-hexadecenoate + H2O = (9Z)-hexadecenoate + ethanol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18424", "l": "acetyl-CoA + chloramphenicol <=> chloramphenicol 3-acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-171106", "l": "LDLR:LDL complex => LDLR + LDL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13916", "l": "L-threonine <=> D-threonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174690", "l": "TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41772", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) = CMP + ganglioside GQ1b (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211191", "l": "Association of DFF with alpha:beta importin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10581", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + ATP + L-glutamate => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n+1 + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15871", "l": "D-glutamate + pyruvate => 2-oxoglutarate + D-alanine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106325", "l": "acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694632", "l": "nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20392", "l": "(2R,3R)-dihydroquercetin + H(+) + NADPH + O2 <=> (2R,3R)-2,3-dihydrogossypetin + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948757", "l": "AKT phosphorylates MKRN1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696958", "l": "USP44 deubiquitinates CDC20 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15564", "l": "S-adenosyl-L-methionine + sterigmatocystin <=> 8-O-methylsterigmatocystin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21483", "l": "2-furoyl-CoA + A + H2O <=> 5-hydroxy-2-furoyl-CoA + AH2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050617", "l": "15,16-dihydrobiliverdin:ferredoxin oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17405", "l": "N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine = H(+) + N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.105", "l": "\"N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56811", "l": "ATP + cob(I)yrinate a,c diamide--[corrinoid adenosyltransferase] <=> adenosylcob(III)yrinate a,c-diamide + apo-[corrinoid adenosyltransferase] + triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22836", "l": "a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]"}, {"i": "EC:2.3.1.41", "l": "\"Beta-ketoacyl-[acyl-carrier-protein] synthase I\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-184269", "l": "Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42903", "l": "guanosine(745) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46618", "l": "(23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin] => calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849908", "l": "SALM4 binds flotillin-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210285", "l": "Trans-homophilic interaction of PECAM-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814409", "l": "CK2 phosphorylates PDCL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19387", "l": "H(+) + raucaffricine + UDP => UDP-alpha-D-glucose + vomilenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421508", "l": "Synthesis of ALAS1 nascent polypeptide (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41851", "l": "(2E)-octenoyl-[ACP] + H(+) + NADPH <=> NADP(+) + octanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10339", "l": "citrate <=> D-threo-isocitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18918", "l": "5alpha-cholest-7-en-3beta-ol + H(+) + NADPH + O2 => cholesta-5,7-dien-3beta-ol + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61967", "l": "2 [Fe(II)-cytochrome b5] + a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a 1-O-(1Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805620", "l": "KAT6A and PML bind TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448660", "l": "IL31:IL31RA:JAK1 binds OSMR:JAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202127", "l": "eNOS synthesizes NO (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64337", "l": "H(+) + 2 malonyl-CoA + nicotinyl-CoA => 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111956", "l": "Calmodulin activates Cam-PDE 1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050253", "l": "retinyl-palmitate esterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57676", "l": "4-epi-eremophilene + O2 + reduced [NADPH--hemoprotein reductase] = 4-epi-eremophilene-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937654", "l": "IL10 positively regulates plasma membrane-associated inflammatory mediators (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30754", "l": "ATP + CoA + hexadecanoate <=> AMP + diphosphate + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624951", "l": "TNPO1 binds KIF17 dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40542", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003949", "l": "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39298", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + AH2 + O2 <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982645", "l": "GRKs bind ADRB2:Catecholamine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204863", "l": "Interaction of Tie2 with Ang2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36101", "l": "methyl benzoate + S-adenosyl-L-homocysteine => benzoate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30095", "l": "(S)-malate + a menaquinone = a menaquinol + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49910", "l": "(R)-carnitine(in) + O-acetyl-(R)-carnitine(out) => (R)-carnitine(out) + O-acetyl-(R)-carnitine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.362", "l": "\"Alpha-(1->3) branching sucrase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034602", "l": "oxoglutarate dehydrogenase (NAD+) activity"}, {"i": "RHEA:27786", "l": "2-oxoglutarate + CoA + NAD(+) = CO2 + NADH + succinyl-CoA"}, {"i": "EC:1.2.1.105", "l": "\"2-oxoglutarate dehydrogenase system\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418579", "l": "Gq activation by P2Y purinoceptor 1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51420", "l": "a (2S,3S)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-435244", "l": "PECAM1 is phosphorylated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32309", "l": "H2O + leukotriene A4 => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40767", "l": "(20S)-ginsenoside R1 + H2O = (20S)-ginsenoside Rg1 + D-xylose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549322", "l": "OCT1 transports organic cations out of hepatic cells (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864105", "l": "PTPN18 binds ERBB2:EGFR heterodimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43129", "l": "guanosine(10) in tRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43824", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635424", "l": "Rv3364c binds cathepsin G (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15702", "l": "AH2 + all-trans-neurosporene + O2 => A + all-trans-lycopene + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24087", "l": "all-trans-zeaxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-antheraxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380930", "l": "Phosphorylated AMPK binds AMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031681", "l": "G-protein beta-subunit binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38218", "l": "D-glucose 6-phosphate + NAD(+) <=> 6-phospho-D-glucono-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306876", "l": "NLRP3 activation by small molecules (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19324", "l": "N,N-dimethylaniline N-oxide <=> formaldehyde + N-methylaniline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48543", "l": "1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O <=> dodecanoate + dodecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0016715", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen"}, {"i": "EC:1.14.17.-", "l": "\"With reduced ascorbate as one donor, and incorporation of one atom of oxygen\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45190", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13593", "l": "allantoate + 2 H(+) + H2O = CO2 + NH4(+) + ureidoglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618750", "l": "CaMKII phosphorylates AMPA receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102454", "l": "cyanidin 3-O-galactosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029273", "l": "PI3K binds to p-6Y-SYK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24110", "l": "2-oxoglutarate + methylamine => H2O + N-methyl-2-oxoglutaramate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731924", "l": "EDNRA binds EDNs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870698", "l": "FASLG (FasL) gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46551", "l": "2 [Fe(II)-cytochrome b5] + a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + 2 H2O + N-acyl-(4E,8E,10E)-sphingatrienine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607753", "l": "CARD9 oligomerizes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72697", "l": "Start codon recognition (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030343", "l": "vitamin D3 25-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653754", "l": "UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193997", "l": "CYP11B1 oxidises 11DCORT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848606", "l": "PTK6 phosphorylates PXN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25494", "l": "(-)-beta-phellandrene + diphosphate => (2E)-geranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13376", "l": "H2O + L-mimosine <=> 3-hydroxy-4H-pyrid-4-one + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693598", "l": "ATM phosphorylates NBN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046026", "l": "precorrin-4 C11-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047881", "l": "estradiol 17-alpha-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033791", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity"}, {"i": "RHEA:15733", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2"}, {"i": "EC:1.17.99.3", "l": "\"3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66277", "l": "tigogenin + UDP-alpha-D-glucose => H(+) + tigogenin 3-O-beta-D-glucopyranoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13070", "l": "ATP + ethanolamine => ADP + H(+) + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22075", "l": "ATP + L-ribulose <=> ADP + H(+) + L-ribulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062189", "l": "anandamide 14,15 epoxidase activity"}, {"i": "RHEA:53148", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40965", "l": "2 2-aminophenoxazin-3-one + 6 H2O => 4 2-aminophenol + 3 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211239", "l": "SIRT1 deacetylates TAF1B in SL1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940100", "l": "CDK1 phosphorylates VCPIP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43827", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102182", "l": "4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol dehydrogenase/C4-decarboxylase activity"}, {"i": "MetaCyc:RXN-11938"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938382", "l": "LGALS3 gene expression is stimulated by RUNX1 and RUNX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22937", "l": "H2O + N-acetyl-D-glucosamine 6-phosphate => acetate + D-glucosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.76", "l": "\"Myeloblastin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638007", "l": "RP2 activates the GTPase activity of ARL3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008043", "l": "MAPK8 phosphorylation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432164", "l": "Ca2+ influx into the post-synaptic cell (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209910", "l": "Iodide is taken up by thyroid epithelial cells (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170149", "l": "Translocation of active Cdc25C to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102311", "l": "8-hydroxygeraniol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22739", "l": "5-formimidoyltetrahydrofolate + 2 H(+) <=> 5,10-methenyltetrahydrofolate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008871", "l": "aminoglycoside 2''-nucleotidyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854738", "l": "CSF3 dimer:CSFR binds CSFR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60474", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) + 5-formyltetrahydrofolate(in) => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) + 5-formyltetrahydrofolate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48825", "l": "GDP-beta-L-fucose + Lc4Cer => a lactoside III(4)-a-Fuc-Lc4Cer + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432688", "l": "trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353494", "l": "Elongation by Pol kappa (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40697", "l": "1-O-heptadecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + heptadecan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683925", "l": "ULK1 is dephosphorylated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197958", "l": "FPGS-2 transforms THF to THFPG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21679", "l": "2 dimethylallyl diphosphate <=> (R)-lavandulyl diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0009679", "l": "hexose:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18358", "l": "NADP(+) + tropine => H(+) + NADPH + tropinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210290", "l": "Interaction of PECAM-1 and SHIP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071889", "l": "14-3-3 protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449087", "l": "CD4 binds Interleukin-16 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14609", "l": "D-sorbitol + NADP(+) = H(+) + keto-L-sorbose + NADPH"}, {"i": "EC:1.1.1.289", "l": "\"Sorbose reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36929", "l": "3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoA => (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24667", "l": "2 N(omega)-hydroxy-L-arginine + NADPH + 2 O2 <=> H(+) + 2 H2O + 2 L-citrulline + NADP(+) + 2 nitric oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66158", "l": "CoA + H(+) + N-butanoyltyramine => butanoyl-CoA + tyramine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030976", "l": "thiamine pyrophosphate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8934465", "l": "SHC1 binds PTPN12 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-169895", "l": "Crk's SH3 domain engages C3G (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0031763", "l": "galanin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174445", "l": "RPA binds to the Flap on the C-strand (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61972", "l": "1-O-(13-methyltetradecyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 1-O-(1Z-13-methyltetradecenyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168768", "l": "JAK2 binds STAT1/3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875531", "l": "MET binds TNS4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27277", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) <=> 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416562", "l": "p190RhoGAP binds Plexin-B1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16103", "l": "n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+) => n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140683", "l": "histone H3-di/monomethyl-lysine-9 demethylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51846", "l": "(9Z)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (9Z)-hexadecenoate(out) + ATP(in) + CoA(in) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22614", "l": "acetyl-CoA + pyruvate => (3S)-citramalyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374701", "l": "Phosphorylation of DCC by Fyn (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35723", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphate = 1-hexadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9010815", "l": "SLITs bind keratan sulfate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-560498", "l": "Expression of Lipoprotein lipase (LPL) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42481", "l": "2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + catechol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39546", "l": "3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19825", "l": "(2E,6E)-farnesyl diphosphate = (+)-aristolochene + diphosphate"}, {"i": "EC:4.2.3.9", "l": "\"Aristolochene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937844", "l": "SRC,YES1 phosphorylate YAP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42872", "l": "N(4)-aminopropylspermidine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + N(4)-bis(aminopropyl)spermidine + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32458", "l": "(-)-vetispiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + solavetivone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609747", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN3A (GRIN3A) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22706", "l": "4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4(+) => 2 H2O + ricinine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.202", "l": "\"2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-912727", "l": "CBL binds VAV (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45870", "l": "4-hydroxy-6-(non-8-en-1-yl)-pyran-2-one + 2 CO2 + 3 CoA => 9-decenoyl-CoA + 2 H(+) + 2 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32782", "l": "ATP + Co(2+)(out) + H2O <=> ADP + Co(2+)(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19960", "l": "2 5'-dehydroinosine + O2 <=> 2 9-riburonosylhypoxanthine + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.3.-", "l": "\"With reduced pteridine as one donor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.152"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30592", "l": "H2O + O2 + tyramine => (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789325", "l": "Expression of IL13-downregulated extracellular proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-350769", "l": "trans-Golgi Network Coat Activation (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26024", "l": "8'-apo-beta-carotenol + O2 => (3E,5E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375135", "l": "Basigin binds Matrix metalloproteinase-1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54694", "l": "(13E)-labda-7,13-dien-15-yl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42349", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37189", "l": "1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432010", "l": "Aquaporin-1 passively transports water into cell (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43886", "l": "3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH => 3-oxochol-4-en-22-oyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103030", "l": "ethylglyoxal reductase (NADH-dependent, hydroxyacetone-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786110", "l": "JAK1 binds IL4R in IL13-bound IL13R type II (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20629", "l": "H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate"}, {"i": "RHEA:47004", "l": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate"}, {"i": "EC:3.1.3.16", "l": "\"Protein-serine/threonine phosphatase\""}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:1903763", "l": "gap junction channel activity involved in cell communication by electrical coupling"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139941", "l": "Binding of IP3 to IP3 receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50751", "l": "H2O + juglone <=> naphthalene-1,2,4,8-tetrol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70899", "l": "histidine => urocanate + NH4+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45284", "l": "eicosanoyl-CoA + sphing-4-enine = CoA + H(+) + N-eicosanoyl-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050356", "l": "tropine dehydrogenase activity"}, {"i": "MetaCyc:TROPINE-DEHYDROGENASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198599", "l": "AKT phosphorylates MDM2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22169", "l": "UDP-alpha-D-glucose => UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11503", "l": "3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O <=> 3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32490", "l": "CDP-choline + H2O <=> CMP + 2 H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18135", "l": "adenosine 5'-phosphosulfate + diphosphate => ATP + H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12234", "l": "[thioredoxin]-dithiol + glycine + H(+) + phosphate => [thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038198", "l": "auxin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30470", "l": "(2Z,6Z)-farnesyl diphosphate <=> (+)-endo-beta-bergamotene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21153", "l": "trans-4-hydroxy-L-proline => cis-4-hydroxy-D-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209231", "l": "DOME:HOP complex forms a dimer at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29963", "l": "H(+)(in) + inosine(in) = H(+)(out) + inosine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086083", "l": "SUMOylation of ING2 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27621", "l": "(2Z,6E)-farnesyl diphosphate + 11 isopentenyl diphosphate <=> di-trans,undeca-cis-tetradecaprenyl diphosphate + 11 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46776", "l": "a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.19.45", "l": "\"sn-1 oleoyl-lipid 12-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2509838", "l": "ITPA hydrolyses dITP to dIMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47984", "l": "H2O + presqualene diphosphate = diphosphate + hydroxysqualene"}, {"i": "EC:4.2.3.156", "l": "\"Hydroxysqualene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9612501", "l": "SGK phosphorylates CREB1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0051020", "l": "GTPase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20712", "l": "6-carboxyhexanoyl-CoA + H(+) + L-alanine = (S)-8-amino-7-oxononanoate + CO2 + CoA"}, {"i": "RHEA:42288", "l": "6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (S)-8-amino-7-oxononanoate + CO2 + holo-[ACP]"}, {"i": "EC:2.3.1.47", "l": "\"8-amino-7-oxononanoate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24680", "l": "5,10-methylenetetrahydromethanopterin + H2O => 5,6,7,8-tetrahydromethanopterin + formaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174367", "l": "GCL ligates L-Glu to L-Cys (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64393", "l": "a dipeptide(out) + H(+)(out) => a dipeptide(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964280", "l": "Active Gq binds BTK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54574", "l": "a pseudouridine in tRNA => a uridine in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48668", "l": "20-hydroxy-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690196", "l": "USP8 deubiquitinates RNF128 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43334", "l": "2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine => adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6804100", "l": "HMGB1 binds LPS (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38495", "l": "a triacylglycerol + H2O = a 1,3-diacylglycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75080", "l": "Formation of AT-AC A complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45705", "l": "(E)-sinapoyl alcohol + NADP(+) => (E)-sinapoaldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23886", "l": "1-methylnicotinamide + S-adenosyl-L-homocysteine => nicotinamide + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017147", "l": "Wnt-protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48848", "l": "(9Z,12Z)-octadecadienoate + O2 = 13-hydroperoxy-(9Z,11E)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25804", "l": "H2O + O2 + spermine = 3-aminopropanal + H2O2 + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111879", "l": "PIP2 hydrolysis (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18920", "l": "5alpha-cholest-7-en-3beta-ol + H(+) + NADPH + O2 <=> cholesta-5,7-dien-3beta-ol + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12184", "l": "(S,S)-butane-2,3-diol + NAD(+) = (S)-acetoin + H(+) + NADH"}, {"i": "EC:1.1.1.76", "l": "\"(S,S)-butanediol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57979", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose <=> (20S)-ginsenoside C-K + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42854", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine => 3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46570", "l": "5-hexynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 5-hexenoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "80.661393760018115", "identifiers": [{"i": "GO:0015651", "l": "quaternary ammonium group transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160915", "l": "Receptor-mediated uptake of HA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350651", "l": "Caspase-mediated cleavage of MASK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32339", "l": "(+)-thujan-3-ol + NADP(+) = (+)-thujan-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685318", "l": "BCDX2 complex formation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39351", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA = (2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707683", "l": "PGRMC2 binds Hemes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879273", "l": "mycothiol conjugates with electrophilic xenobiotic (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49046", "l": "4-hydroxyprotoasukamycin + H2O + NAD(+) => H(+) + NADH + O2 + protoasukamycin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35541", "l": "albonoursin + H2O2 => cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173636", "l": "Formation of classic pathway C5 convertase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635848", "l": "GLI proteins bind PTCH1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14885", "l": "H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] = ADP-D-ribose + L-arginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6795290", "l": "TORC2 complex phosphorylates SGK1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20831", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26144", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102025", "l": "ABC-type thiosulfate transporter activity"}, {"i": "RHEA:29871", "l": "ATP + H2O + thiosulfate(out) = ADP + H(+) + phosphate + thiosulfate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879222", "l": "MDP:NLRP1 binds ATP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43459", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA <=> (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25242", "l": "(S)-2-ureidoglycine + H2O => (S)-ureidoglycolate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000247", "l": "Endosomal CBLIF:Cbl translocates to lysosome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3341294", "l": "Superoxide reduces cytochrome c (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9612509", "l": "SGK phosphorylates SRF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977239", "l": "Activated IRAK4 bound to activated TLR : MyD88 complex phosphorylates IRAK2    (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38878", "l": "uridine(2604) in 23S rRNA <=> pseudouridine(2604) in 23S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64206", "l": "1-(10Z-heptadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40191", "l": "(3R)-hydroxyoctanoyl-CoA + NAD(+) = 3-oxooctanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191737", "l": "Docking of connexons into junctional, double-membrane spanning channels (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008121", "l": "ubiquinol-cytochrome-c reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214410", "l": "Monomeric PGN binds to PGRP-LE in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51912", "l": "(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22365", "l": "L-quinate + NAD(+) => 3-dehydroquinate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60028", "l": "(2E)-geranyl diphosphate + H2O = 4-terpineol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.5", "l": "\"NAD(+) glycohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909729", "l": "Activation of JAK kinases (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205286", "l": "GRB2:SOS interacts with p-KIT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33165", "l": "beta-nicotinamide D-riboside(out) => beta-nicotinamide D-riboside(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57837", "l": "H2O + O2 + thermospermine => 3-aminopropanal + H2O2 + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786092", "l": "IL4:IL4R:JAK2 binds IL2RG:JAK3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58883", "l": "4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31623", "l": "L-olivosyl-oleandolide + S-adenosyl-L-methionine = H(+) + L-oleandrosyl-oleandolide + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.239", "l": "\"L-olivosyl-oleandolide 3-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032266", "l": "phosphatidylinositol-3-phosphate binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045438", "l": "delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2467775", "l": "Autocleavage of ESPL1 (Separase) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50793", "l": "18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] => aldosterone + 2 H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706293", "l": "Active FLT3 binds to CBL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57204", "l": "glyoxal + L-lysyl-[protein] = N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63699", "l": "SN-38 + UDP-alpha-D-glucuronate <=> H(+) + SN-38 O-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097509", "l": "oxanine DNA N-glycosylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788623", "l": "p-Y-STATs translocate to nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483089", "l": "PE is converted to PS by PTDSS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29217", "l": "menaquinone-8 + succinate => fumarate + menaquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033509", "l": "USP9X binds Ub:PEX5L (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164967", "l": "Unknown carnitine exporter transports CAR from the cytosol to the extracellular space (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64010", "l": "CoA + H(+) + N-hexadecanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44831", "l": "(R)-carnitine + decanoyl-CoA <=> CoA + O-decanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15710", "l": "kaempferol + UDP-alpha-D-galactose => H(+) + kaempferol 3-O-beta-D-galactoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3204303", "l": "MRE11 binds cytosolic DNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060072", "l": "large conductance calcium-activated potassium channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186773", "l": "PDGF dimer binds two receptors simultaneously (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21308", "l": "(S)-2,3-epoxysqualene = cycloartenol"}, {"i": "EC:5.4.99.8", "l": "\"Cycloartenol synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015577", "l": "galactitol transmembrane transporter activity"}, {"i": "RHEA:33143", "l": "galactitol(in) = galactitol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60381", "l": "L-dehydroascorbate(out) => L-dehydroascorbate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30986", "l": "H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] <=> beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247844", "l": "WNT ligands traffic to the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63689", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41869", "l": "decanoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15285", "l": "AMP + dimethylallyl diphosphate = diphosphate + N(6)-(dimethylallyl)adenosine 5'-phosphate"}, {"i": "EC:2.5.1.27", "l": "\"Adenylate dimethylallyltransferase (AMP-dependent)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684352", "l": "nsp3-4 cleaves itself (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56801", "l": "apo-[corrinoid adenosyltransferase] + cob(II)yrinate a,c diamide => cob(II)yrinate a,c diamide--[corrinoid adenosyltransferase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15677", "l": "5-aminopentanamide + H2O = 5-aminopentanoate + NH4(+)"}, {"i": "EC:3.5.1.30", "l": "\"5-aminopentanamidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66642", "l": "diphosphate + koraiol => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37724", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13576", "l": "[(1->4)-alpha-D-galacturonosyl](n) + UDP-alpha-D-galacturonate <=> [(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55254", "l": "2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63652", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50618", "l": "(3E)-nonen-2-one + H(+) + NADPH => NADP(+) + nonan-2-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879674", "l": "CD97 binds CD55 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58263", "l": "H2O + O-(ADP-D-ribosyl)-L-tyrosyl-[protein] <=> ADP-D-ribose + L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-912627", "l": "CBL ubiquitinates PI3K (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16460", "l": "(2R,3S)-tartrate + NAD(+) <=> 2-hydroxy-3-oxosuccinate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31874", "l": "(S)-2,3-epoxysqualene <=> alpha-seco-amyrin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5658435", "l": "RAS GAPs bind RAS:GTP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3134914", "l": "Beta-catenin migrates to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36938", "l": "(11E)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (9Z,11E)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46082", "l": "NAD(+) + tetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36768", "l": "2-hydroxytetracosenoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxytetracosenoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36961", "l": "D-ribose + NAD(+) => D-ribono-1,4-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51337", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => 8-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59495", "l": "(2E)-geranyl diphosphate + L-tryptophyl-[protein] <=> (2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52148", "l": "an (E)-omega-(methylsulfanyl)alkyl-thiohydroximate + UDP-alpha-D-glucose = an aliphatic desulfo-glucosinolate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64204", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(10Z-heptadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49633", "l": "(2E,6E)-farnesyl diphosphate + 3,5-dimethylorsellinate => (3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641205", "l": "RSPO:LGR binds ZNRF3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59590", "l": "ADP + beta-alanyl-L-ornithine + H(+) + phosphate => ATP + beta-alanine + L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33319", "l": "a 1-acyl-sn-glycero-3-phosphate + octadecanoyl-CoA = a 1-acyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607751", "l": "TRAF6 oligomerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60704", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-2,3-cyclic phosphate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56521", "l": "Fe-coproporphyrin III + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + 2 CO2 + heme b + 2 L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654571", "l": "Activated FGFR1 binds FRS3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54781", "l": "[LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine => [LarE protein]-dehydroalanine + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20165", "l": "H2O + N(5)-acyl-L-ornithine ester = an alcohol + H(+) + N(5)-acyl-L-ornithine"}, {"i": "EC:3.1.1.48", "l": "\"Fusarinine-C ornithinesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696960", "l": "USP49 deubiquitinates H2B (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1564120", "l": "Collagen type VII degradation by MMP1,2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010435", "l": "3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11748", "l": "fluoroacetaldehyde + L-threonine = 4-fluoro-L-threonine + acetaldehyde"}, {"i": "EC:2.2.1.8", "l": "\"Fluorothreonine transaldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48166", "l": "H(+) + red chlorophyll catabolite => epoxypheophorbide a + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33106", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-muurolene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654544", "l": "Ligand-independent dimerization of overexpressed FGFR1c (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2328145", "l": "Laminin-111 binds collagen type IV (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9007539", "l": "CHEK1 phosphorylates E2F6 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351948", "l": "Mitochondrial recruitment of Drp1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61413", "l": "ATP + N-(D-erythrulosyl)-cadaverine => ADP + H(+) + N-(3-O-phospho-D-erythrulosyl)-cadaverine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878130", "l": "CDKN1A (p21) gene expression is positively regulated by RUNX3 and ZFHX3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21089", "l": "2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2 => a flavonol + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53271", "l": "L-ribulose <=> L-xylulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55465", "l": "11-hydroxysugiol + O2 + reduced [NADPH--hemoprotein reductase] => 11,20-dihydroxysugiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507869", "l": "Aquaporins passively transport glycerol into cells (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59226", "l": "diphosphate + hydropyrene => (2E,6E,10E)-geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31455", "l": "NAD(+) + reduced riboflavin = 2 H(+) + NADH + riboflavin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62145", "l": "dGMP + dGTP => 2 dGDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55786", "l": "all-trans-4-oxoretinoate 1-O-(beta-D-glucuronate) + UDP => all-trans-4-oxoretinoate + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32016", "l": "(2E,6E)-farnesyl diphosphate => (-)-delta-cadinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43092", "l": "S-adenosyl-L-methionine + uridine(2479) in 23S rRNA = 2'-O-methyluridine(2479) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.208", "l": "\"23S rRNA (uridine(2479)-2'-O)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008609", "l": "alkylglycerone-phosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42125", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) => 3alpha-hydroxy-5alpha-androstan-17-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678854", "l": "S1PR1 binds S1PR1 agonists (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140440", "l": "protein-cysteine S-oleoyltransferase activity"}, {"i": "RHEA:59744", "l": "(9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177937", "l": "Phosphorylation of EGFR by SRC kinase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42400", "l": "lactose(out) + N(pros)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + lactose 6-phosphate(in)"}, {"i": "EC:2.7.1.207", "l": "\"Protein-N(pi)-phosphohistidine--lactose phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49172", "l": "8,12-diethyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine = 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928620", "l": "PAK1 autophosphorylates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17005", "l": "ATP + D-glucuronate = 1-phospho-alpha-D-glucuronate + ADP + H(+)"}, {"i": "EC:2.7.1.43", "l": "\"Glucuronokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29323", "l": "fumarate(in) + succinate(out) = fumarate(out) + succinate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65557", "l": "globoside GalGb4Cer + H2O => an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13643", "l": "H2O + methanol + NADP(+) => H(+) + methane + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22903", "l": "(R)-acetoin + NAD(+) <=> diacetyl + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48059", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O <=> beta-D-glucosylceramide + D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46398", "l": "2 [Fe(III)-cytochrome b5] + an (11E)-Delta(11)-fatty acyl-CoA + 2 H2O => 2 [Fe(II)-cytochrome b5] + an 11,12-saturated fatty acyl-CoA + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008672", "l": "2-dehydro-3-deoxyglucarate aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507871", "l": "Aquaporins passively transport glycerol out of cells (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62374", "l": "(6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350578", "l": "NQO1 interaction with ODC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55572", "l": "4-hydoxytryptamine 4-phosphate + S-adenosyl-L-methionine = 4-hydroxy-N-methyltryptamine 4-phosphate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51577", "l": "phloretin + UDP-alpha-D-glucose => H(+) + phlorizin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33044", "l": "(1R,4R)-camphor + H(+) + NADPH + O2 => (+)-6-exo-hydroxycamphor + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65783", "l": "2 H(+) + metoxuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-(3-chloro-4-methoxylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64922", "l": "a 2'-deoxyribonucleoside 5'-phosphate + H(+) + phosphate => a 2'-deoxyribonucleoside 5'-diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55193", "l": "2-oxoglutarate + 3-methyldodecanoyl-CoA + O2 => 2-hydroxy-3-methyldodecanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19642", "l": "(E)-4-coumarate + ATP + CoA => (E)-4-coumaroyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432483", "l": "SLMB binds phosphorylated nuclear PER, facilitating its ubiquitination (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62399", "l": "(1S,2S)-pseudoephedrine + NAD(+) <=> (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39434", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18198", "l": "H(+) + N-cyclohexylformamide => cyclohexyl isocyanide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417829", "l": "P2RY12 binds ADP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26407", "l": "H(+) + 4 H2O + phosphate + pyridoxal 5'-phosphate => aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032089", "l": "NACHT domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22567", "l": "a 2,3-saturated acyl-[ACP] + NADP(+) <=> a (2E)-enoyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66602", "l": "2 dopamine quinone + 2 H2O => 2 dopamine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607747", "l": "TRAF6 binds MALT1 oligomers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60108", "l": "(R)-3-(4-hydroxyphenyl)lactoyl-CoA = (E)-4-coumaroyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46534", "l": "2 [Fe(III)-cytochrome b5] + a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-containing glycerolipid + 2 H2O => 2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52063", "l": "12-(9Z-octadecenoyloxy)-octadecanoate + H2O <=> (9Z)-octadecenoate + 12-hydroxyoctadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57408", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + NAD(+) = 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047908", "l": "fusarinine-C ornithinesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209076", "l": "SPZ dimer bound TL dimerises at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50727", "l": "(E)-4-hydroxyphenylacetaldehyde oxime <=> (Z)-(4-hydroxyphenyl)acetaldehyde oxime"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9658813", "l": "OGG1 S326C is oxidized (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36103", "l": "anthranilate + S-adenosyl-L-methionine = O-methyl anthranilate + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.277", "l": "\"Anthranilate O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22889", "l": "(R)-methylmalonyl-CoA => succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443779", "l": "Linkage of L1 with treadmilling F-actin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863494", "l": "ASICs bind STOML3, (STOM) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102262", "l": "tRNA-dihydrouridine16 synthase activity"}, {"i": "MetaCyc:RXN-12454"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614810", "l": "Activation of Latent HCMV Genome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15839", "l": "N-methyl-L-glutamate + NH4(+) => L-glutamate + methylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381608", "l": "cAMP activates EPAC2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28391", "l": "N(6)-(D-psicosyl)-L-lysine => N(6)-(D-fructosyl)-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13067", "l": "ADP + H(+) + phosphate => ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17774", "l": "ATP + L-cysteine + tRNA(Cys) => AMP + diphosphate + L-cysteinyl-tRNA(Cys)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938108", "l": "SERPINB13 binds cathepsin L (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26155", "l": "(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil <=> 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944232", "l": "Association of procollagen type XII (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34918", "l": "D-galactose(in) <=> D-galactose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25356", "l": "2-hydroxyphytanoyl-CoA => 2,6,10,14-tetramethylpentadecanal + formyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003680", "l": "minor groove of adenine-thymine-rich DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59714", "l": "D-maltotetraonate + H(+) => D-maltotetraono-1,5-lactone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16487", "l": "1-(5-phosphoribosyl)imidazole-4-acetate + ADP + diphosphate + H(+) + phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazole-4-acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44937", "l": "(9Z,12Z,15Z)-octadecatrienoate + ATP + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26320", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate <=> 3-amino-4-hydroxybenzoate + H(+) + 2 H2O + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804242", "l": "TP53 binds the complex of JMY, EP300 and TTC5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008999", "l": "ribosomal-protein-alanine N-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51368", "l": "glycine + octadecanoyl-CoA = CoA + H(+) + N-octadecanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24900", "l": "cyclic di-3',5'-guanylate + 2 diphosphate => 2 GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47222", "l": "3beta,16alpha-dihydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65641", "l": "(4R)-hydroxysphing-(8Z)-enine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8Z)-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936628", "l": "GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26521", "l": "3-hydroxypropanoyl-CoA <=> acryloyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57831", "l": "dIMP + H2O <=> 2-deoxy-D-ribose 5-phosphate + hypoxanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51877", "l": "2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate => desmethylxanthohumol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606273", "l": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877902", "l": "Activated AR binds RUNX2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647746", "l": "EML4 trimerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769383", "l": "CBY1 binds beta-catenin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35182", "l": "6 H(+) + hexanoyl-[ACP] + 7 malonyl-CoA <=> 7 CO2 + 7 CoA + 2 H2O + holo-[ACP] + noranthrone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27916", "l": "4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate => 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0018671", "l": "4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity"}, {"i": "MetaCyc:1.14.13.33-RXN"}, {"i": "EC:1.14.13.33", "l": "\"4-hydroxybenzoate 3-monooxygenase (NAD(P)H)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018828", "l": "halohydrin hydrogen-halide-lyase A activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41177", "l": "[methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine => [Co(I) dimethylamine-specific corrinoid protein] + dimethylamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46116", "l": "2-dehydro-3-deoxy-D-galactonate = D-glyceraldehyde + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322427", "l": "Beta-catenin recruits CBP/p300 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40813", "l": "(9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40756", "l": "(9Z,12Z)-octadecadienoate + 1-hexadecanoylglycerone 3-phosphate => 1-(9Z,12Z)-octadecadienoylglycerone 3-phosphate + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-532630", "l": "p-IRAK2- TRAF6 dissociates from the activated TRL7 or 21 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018551", "l": "hydrogensulfite reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71050", "l": "Trimerization of the FASL:FAS receptor complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18469", "l": "an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)"}, {"i": "EC:2.3.1.68", "l": "\"Glutamine N-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215295", "l": "USP7 deubiquitinates MDM2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64834", "l": "3-hydroxy-benzyl benzoate + CoA => 3-hydroxybenzyl alcohol + benzoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694575", "l": "Nucleoprotein translocates to the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27310", "l": "naphthalene-1,2-diol + O2 = 2-hydroxychromene-2-carboxylate + H(+)"}, {"i": "EC:1.13.11.56", "l": "\"1,2-dihydroxynaphthalene dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004416", "l": "hydroxyacylglutathione hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987039", "l": "JAK1 binds IL20RA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851888", "l": "MET binds SHC1-2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58099", "l": "1-tetracosanoylglycerol + H2O <=> glycerol + H(+) + tetracosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696605", "l": "USP12, USP26 deubiquitinate AR (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935972", "l": "TJP1 (ZO-1) gene expression is stimulated by RUNX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62071", "l": "2-deoxy-D-glucose 6-phosphate + NADP(+) <=> 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19631", "l": "2-oxoglutarate + CO2 + NADPH => D-threo-isocitrate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693575", "l": "DNA-PKcs autophosphorylates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607753", "l": "CARD9 oligomerizes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47493", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => isodeoxycholate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803063", "l": "RNASEs bind bacterial LPS, PGN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30359", "l": "chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2 = chlorophyllide b + 3 H2O + 2 NADP(+)"}, {"i": "EC:1.14.13.122", "l": "\"Chlorophyllide a oxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52577", "l": "hexanoyl-CoA + NAD(+) => (2E)-hexenoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624120", "l": "CEBPA binds CDK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25644", "l": "(1R,4S)-menthone + NADP(+) <=> (R)-pulegone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44806", "l": "2-demethylmenaquinol-9 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-nonaprenyl diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381612", "l": "GLP1R binds GLP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508451", "l": "PTK2B is phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396594", "l": "Phosphorylation of SLP-76 by p-SYK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38225", "l": "1-O-decyl-(9Z)-octadecenoate + CoA => (9Z)-octadecenoyl-CoA + decan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106341", "l": "omega-hydroxyceramide transacylase activity"}, {"i": "RHEA:55264", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine = di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2995330", "l": "COX10 transforms heme to heme O (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48756", "l": "erythritol + NAD(+) = D-erythrulose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18276", "l": "H2O + O2 + putrescine <=> 4-aminobutanal + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72621", "l": "Ribosomal scanning  (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008938", "l": "nicotinate N-methyltransferase activity"}, {"i": "RHEA:20241", "l": "nicotinate + S-adenosyl-L-methionine = N-methylnicotinate + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.7", "l": "\"Nicotinate N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38702", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670101", "l": "ATRX:DAXX binds to subtelomeric chromosomal regions (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55603", "l": "an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose <=> a mannosylinositol-1-phosphoceramide + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047654", "l": "alliin lyase activity"}, {"i": "MetaCyc:ALLIIN-LYASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193646", "l": "NGF binding to p75NTR inactivates RHOA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5229343", "l": "AXIN is phosphorylated in the destruction complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38180", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 19-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57163", "l": "2-oxoglutarate + L-arginyl-[ribosomal protein eS6] + O2 <=> (3R)-3-hydroxy-L-arginyl-[ribosomal protein eS6] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14038", "l": "4,5beta-dihydrocortisone + NADP(+) => cortisone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662618", "l": "MT1G binds zinc (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44199", "l": "3-methylundecanoate + ATP + CoA <=> 3-methylundecanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030596", "l": "alpha-L-rhamnosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9698844", "l": "MLKL binds HSP90:CDC37 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174786", "l": "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36431", "l": "a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3700997", "l": "TP53 binds the MDM2 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434633", "l": "PIP2 binds inhibiting VAV (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57698", "l": "adenosylcob(III)inamide + apo-[corrinoid adenosyltransferase] + triphosphate => ATP + cob(I)inamide--[corrinoid adenosyltransferase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168445", "l": "PTP1B binds the GH receptor complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12407", "l": "D-glucose + UDP-alpha-D-galactose <=> H(+) + lactose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62293", "l": "(S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) => 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45337", "l": "(9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine => [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15088", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O <=> an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + N-acetyl-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692781", "l": "p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61043", "l": "(+)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39635", "l": "3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "77.690207805941611", "identifiers": [{"i": "GO:0016755", "l": "aminoacyltransferase activity"}, {"i": "EC:2.3.2.-", "l": "\"Aminoacyltransferases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11929", "l": "hydroxylamine + NH4(+) => H(+) + H2O + hydrazine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18210", "l": "(2E)-geranyl diphosphate => (2S,4R)-bornyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34248", "l": "1-deoxymethyl-sphinganine + NADP(+) => 1-deoxymethyl-3-dehydrosphinganine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24816", "l": "2-oxoglutarate + L-valine <=> 3-methyl-2-oxobutanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443783", "l": "Interaction of NUMB with L1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198611", "l": "AKT phosphorylates IKKalpha (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201717", "l": "CSNK2-mediated phosphorylation of DVL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41867", "l": "(2E)-decenoyl-[ACP] + H(+) + NADPH <=> decanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482629", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-169719", "l": "Secreted CD14 binds LPS (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950201", "l": "Expression of Aryl Hydrocarbon receptor-interacting protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19310", "l": "2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O => (2R)-2-O-(alpha-D-mannosyl)-glycerate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989754", "l": "Expression of APOA1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050217", "l": "propioin synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939201", "l": "ESR dimerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672978", "l": "RAF phosphorylates MAP2K dimer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5632652", "l": "Hh-Npp binds CDON and PTCH (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54920", "l": "13-cis-retinol + NADP(+) = 13-cis-retinal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937989", "l": "RUNX1 binds PRC1 complexes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647994", "l": "RAS proteins are depalmitoylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41350", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173723", "l": "C8 binds C5b:C6:C7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57271", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP <=> GMP + H(+) + lactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603784", "l": "PEX19:class I PMP binds PEX3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698033", "l": "p-STAT5 translocates to nucleus downstream of mutant FLT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57558", "l": "2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + zealexin A1 => (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419841", "l": "Light stimulates opsin receptors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9035227", "l": "TXN2 binds CysS248-MPST (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40301", "l": "erythronolide B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 6-deoxyerythronolide B + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31539", "l": "(2S)-naringenin + S-adenosyl-L-methionine = (2S)-sakuranetin + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.232", "l": "\"Naringenin 7-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64190", "l": "a fatty acid + L-tyrosine => an N-(fatty acyl)-L-tyrosine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75187", "l": "TRAIL:TRAIL receptor trimers bind FADD (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57166", "l": "(3R)-3-hydroxy-L-arginyl-[RCC1 domain-containing protein] + CO2 + succinate => 2-oxoglutarate + L-arginyl-[RCC1 domain-containing protein] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421835", "l": "trans-Golgi Network Vesicle Scission (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004849", "l": "uridine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3857336", "l": "CEBPB homodimerization (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166214", "l": "FA anion flip-flops to the opposite surface (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626953", "l": "TNF-alpha:TNFR1 binds DENN/MADD (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950766", "l": "IL27RA dimerizes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37309", "l": "glycine + L-asparagine => glycyl-L-asparagine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202500", "l": "Activation of IKK complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805103", "l": "AURKA phosphorylates TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37329", "l": "ADP + H(+) + L-methionyl-L-alanine(in) + phosphate => ATP + H2O + L-methionyl-L-alanine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73797", "l": "FAICAR => IMP + H2O (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57066", "l": "D-apionate + H(+) => D-apionolactone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57041", "l": "aldehydo-D-apiose => D-apiofuranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58981", "l": "citral + H2O + O2 => 3,7-dimethylocta-2,6-dienoate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50032", "l": "H2O + hexadecanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + hexadecanoyl-4'-phosphopantetheine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39297", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + A + 2 H2O => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25381", "l": "2-methylpentadecanal + formyl-CoA => 2-hydroxy-3-methylhexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63778", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine => 1-O-hexadecyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186786", "l": "Autophosphorylation of PDGF beta receptors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59190", "l": "D-histidine => L-histidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21587", "l": "NAD(+) + propane-1,2-diol 1-phosphate <=> H(+) + hydroxyacetone phosphate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052588", "l": "diacetyl reductase ((S)-acetoin forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64859", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + phomopsene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026891", "l": "NTRK2 activates RAS signaling through SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23225", "l": "trans-zeatin + UDP-alpha-D-glucose => H(+) + O-beta-D-glucosyl-trans-zeatin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.26"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2288097", "l": "Condensin II complex binds H4K20me1-containing nucleosomes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446372", "l": "Association of  PARVA with TESK1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19330", "l": "nuatigenin + UDP-alpha-D-glucose => H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52226", "l": "3 A + biliverdin delta + CO + Fe(2+) + 3 H2O => 3 AH2 + 3 H(+) + heme b + 3 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549304", "l": "OCT3 mediates renal clearance of organic cations (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30835", "l": "H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose = NADP(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4332236", "l": "CBL neddylates TGFBR2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814671", "l": "Fusion of late-endosome derived vesicles at the TGN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114284", "l": "Release of Cytochrome c from mitochondria (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449077", "l": "Interleukin-16 is secreted (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60317", "l": "N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865605", "l": "BRWD1 binds SMARCA4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668605", "l": "RAC2:GTP binds NOX2 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352956", "l": "glyceraldehyde 3-phosphate + NAD+ + phosphate <=> 1,3-bisphosphoglycerate + NADH + H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67003", "l": "2-methylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 3 CO2 + 4 CoA + phlorisobutanophenone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16587", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin] => [[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22109", "l": "L-threonine => 2-oxobutanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022396", "l": "MME:Zn2+ hydrolyses AGT(34-43) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072587", "l": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111238", "l": "Formation of ADAR2  homodimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13056", "l": "L-phenylalanine + pyruvate <=> 3-phenylpyruvate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5618331", "l": "HDAC6 deacetylates microtubules (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40186", "l": "O2 + tetradecanoyl-CoA <=> (2E)-tetradecenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607736", "l": "MALT1 oligomerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34776", "l": "a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) => a 3-oxosteroid + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24955", "l": "1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O <=> ADP + H(+) + N-acetyl-D-muramate 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40675", "l": "L-threonine = 2-aminobut-2-enoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21134", "l": "H2O2 + urate => H2O + O2 + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42548", "l": "uridine(746) in 23S rRNA = pseudouridine(746) in 23S rRNA"}, {"i": "EC:5.4.99.29", "l": "\"23S rRNA pseudouridine(746) synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37968", "l": "galactitol + NADP(+) => D-galactose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31480", "l": "soyasapogenol A + UDP-alpha-D-glucuronate => H(+) + soyasapogenol A 3-O-beta-D-glucuronate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9656891", "l": "OPN1SW binds 11cRAL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11912", "l": "13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) = 15-oxoprostaglandin E2 + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38182", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 19-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42335", "l": "ATP + L-glutamate + oxidized coenzyme F420-2 <=> ADP + H(+) + oxidized coenzyme alpha-F420-3 + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801109", "l": "CHM binds RGGT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.3.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66697", "l": "(4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + S-adenosyl-L-methionine => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34275", "l": "2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine = 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + H(+) + L-methionine"}, {"i": "EC:1.1.99.38", "l": "\"2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676229", "l": "WIPIs bind PI3P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.23", "l": "\"Beta-galactosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54671", "l": "pre-alpha-onocerin <=> alpha-onocerin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50143", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> (14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730862", "l": "Autophosphorylation of LYN kinase (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199839", "l": "AKT can phosphorylate RSK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034825", "l": "tetralin ring-hydroxylating dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72691", "l": "Formation of the 43S pre-initiation complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57664", "l": "(+)-valencene + O2 + reduced [NADPH--hemoprotein reductase] = alpha-nootkatol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-481044", "l": "Surface deployment of platelet alpha granule membrane components (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57205", "l": "glyoxal + L-lysyl-[protein] => N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24054", "l": "a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein] => a ubiquinone + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47263", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65497", "l": "3beta-hydroxy-5beta-pregnane-20-one + H(+) + NADPH => 3beta,20alpha-dihydroxy-5beta-pregnane + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30557", "l": "GDP + H(+) + oxidized coenzyme F420-1 + phosphate => GTP + L-glutamate + oxidized coenzyme F420-0"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578777", "l": "DMPK phosphorylates PLN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727819", "l": "TAK1 phosphorylates MKK6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54561", "l": "an adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + GTP => a 5'-triphospho-guanosine-ribonucleotide-tRNA(His) + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380782", "l": "STAT binds to the active receptor (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23000", "l": "(R)-pantoate + NAD(+) = (R)-4-dehydropantoate + H(+) + NADH"}, {"i": "EC:1.1.1.106", "l": "\"Pantoate 4-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30536", "l": "biotinate sulfoxide + H(+) + NADPH => biotin + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004661", "l": "protein geranylgeranyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47523", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADPH <=> isolithocholate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50252", "l": "an acyl-CoA + H(+) + malonyl-CoA = a 3-oxoacyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60188", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate"}, {"i": "EC:1.14.11.65", "l": "\"[Histone H3]-dimethyl-L-lysine(9) demethylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56591", "l": "a monosubstituted aliphatic (S)-hydroxynitrile <=> an aldehyde + hydrogen cyanide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21330", "l": "cholest-4-en-3-one + H2O2 => cholesterol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352268", "l": "Cleavage of Satb1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14682", "l": "2 2-aminophenol + A + O2 => 2-aminophenoxazin-3-one + AH2 + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30834", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose <=> UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-hex-4-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1299297", "l": "Activation of THIK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.15"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050344", "l": "trans-cinnamate 2-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174959", "l": "The acetyl group from acetyl-CoA is transferred to the NAT1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22664", "l": "2 1-O-(trans-sinapoyl)-beta-D-glucose = 1,2-di-O-sinapoyl beta-D-glucose + D-glucose"}, {"i": "EC:2.3.1.103", "l": "\"Sinapoylglucose--sinapoylglucose O-sinapoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4615910", "l": "SUMOylation of PCNA with SUMO1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51237", "l": "GTP + L-glutamate + oxidized coenzyme F420-(gamma-Glu)(n) => GDP + H(+) + oxidized coenzyme F420-(gamma-Glu)(n+1) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102692", "l": "benzyladenine UDP glycosyltransferase activity"}, {"i": "MetaCyc:RXN-4730"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023163", "l": "Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19843", "l": "CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390929", "l": "HTR1 and 5A receptors can bind serotonin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50551", "l": "prostaglandin E1 <=> H2O + prostaglandin A1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13590", "l": "3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate => ADP + H(+) + phosphate + trans-3-methylglutaconyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19810", "l": "(S)-ureidoglycolate + 2 H(+) + H2O => CO2 + glyoxylate + 2 NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39263", "l": "(2E,13Z)-docosadienoyl-CoA + H(+) + NADPH = (13Z)-docosenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21410", "l": "3-phenylpyruvate + H(+) + NADH + NH4(+) => H2O + L-phenylalanine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034939", "l": "5-hydroxypyrrole-2-carboxylate tautomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863674", "l": "CDC25C binds YWHAE (14-3-3-epsilon) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3247836", "l": "Retromer recycles WLS to the Golgi (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34571", "l": "C30 botryococcene + diphosphate + NADP(+) = H(+) + NADPH + presqualene diphosphate"}, {"i": "EC:1.3.1.97", "l": "\"Botryococcene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43592", "l": "all-trans-zeaxanthin + O2 = (3R)-3-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052830", "l": "inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity"}, {"i": "REACT:R-HSA-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44902", "l": "D-galactonate + H(+) => D-galactono-1,4-lactone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381668", "l": "cAMP activates EPAC1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50553", "l": "prostaglandin C1 => prostaglandin B1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050189", "l": "phosphoenolpyruvate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28088", "l": "2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H(+) + 2 H2O + phthalate => 2 H2O2 + Reactive Blue 5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156910", "l": "Formation of eEF1B complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15322", "l": "(6aR,11aR)-3,9-dihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] => (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53207", "l": "17beta,19-dihydroxy-3-oxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta-hydroxy-3,19-dioxo-5alpha-androstanone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60131", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O <=> 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30113", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-enterobactin + H(+) + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694656", "l": "Spike trimer glycoside chains are extended (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38490", "l": "1-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395340", "l": "Formation of hydroxyallysine by LOX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1483219", "l": "PC is exchanged with PI by PITPNB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48616", "l": "H2O + leukotriene D4 = glycine + leukotriene E4"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050609", "l": "phosphonate dehydrogenase activity"}, {"i": "RHEA:13173", "l": "H2O + NAD(+) + phosphonate = H(+) + NADH + phosphate"}, {"i": "EC:1.20.1.1", "l": "\"Phosphonate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5576895", "l": "SCNAs:SNCBs transport Na+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001065", "l": "mannan binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693347", "l": "CRYM reduces P2C to PPCA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450474", "l": "MK2 phosphorylates BRF1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450325", "l": "c-FOS activation by phospho ERK1/2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46380", "l": "7alpha-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044692", "l": "exoribonuclease activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27554", "l": "(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate <=> di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49471", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-6-sulfoquinovose <=> a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16310", "l": "H2O + taurochenodeoxycholate => chenodeoxycholate + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31798", "l": "(+)-beta-caryophyllene + H2O <=> (+)-caryolan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40743", "l": "(20S)-ginsenoside Rd + 2 H2O = (20S)-ginsenoside C-K + 2 D-glucose"}, {"i": "EC:3.2.1.191", "l": "\"Ginsenosidase type III\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018114", "l": "threonine racemase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-213406", "l": "Disassociation of PLC-gamma1 from LAT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42151", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acyl-(4R)-4-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141409", "l": "Mad1 binds kinetochore (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.351", "l": "\"Phosphogluconate dehydrogenase (NAD(P)(+)-dependent, decarboxylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202375", "l": "Recruitment of ITK to SLP-76 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54622", "l": "2-hydroxyeicosanoyl-CoA + CO2 + succinate => 2-oxoglutarate + eicosanoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2172666", "l": "RB1 binds condensin II (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24321", "l": "an L-polyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => an L-N-hydroxypolyhomomethionine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.177"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53608", "l": "4-hydroxyestrone + O2 = (2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666008", "l": "SCAI binds SRF:MKL1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12856", "l": "(S)-4-hydroxymandelonitrile + UDP-alpha-D-glucose <=> dhurrin + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0042974", "l": "retinoic acid receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54611", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] <=> a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18255", "l": "CO2 + NADPH + pyruvate => (S)-malate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9686930", "l": "RIPK3 is cleaved by CASP8 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662623", "l": "MT1F binds zinc (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392187", "l": "Activated P2Y purinoceptor 12 binds G-protein Gi (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47737", "l": "cytidine(1404) in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(1404) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55000", "l": "3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46354", "l": "3-hydroxydecanoyl-CoA => (2E)-decenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0050737", "l": "O-hydroxycinnamoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41611", "l": "3'-phosphoadenylyl sulfate + alpha,alpha-trehalose <=> 2-O-sulfo-alpha,alpha-trehalose + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50340", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + testosterone = 1alpha-hydroxytestosterone + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.3.2.-", "l": "\"Linked to the hydrolysis of a nucleoside triphosphate\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21666", "l": "4-nitrophenol + H(+) + phosphate => 4-nitrophenyl phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814734", "l": "CDSN binds the cornified envelope (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670155", "l": "CDC42:GTP binds PtdIns(4,5)P2:WASP,N-WASP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38769", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44240", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol = a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + di-(9Z)-octadecenoylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24958", "l": "(R)-lactate + N-acetyl-beta-D-glucosamine 6-phosphate => H2O + N-acetyl-beta-D-muramate 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46467", "l": "(24S)-25-epoxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S,25)-epoxy-7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34618", "l": "2-hydroxyethylphosphonate + O2 <=> H(+) + hydrogencarbonate + methylphosphonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52854", "l": "6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin] => a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043767", "l": "pyrrolysyl-tRNA synthetase activity"}, {"i": "MetaCyc:6.1.1.26-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507873", "l": "Aquaporins passively transport urea out of cells (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806831", "l": "CYB5Rs reduce MetHb to HbA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18179", "l": "a (2E)-enoyl-CoA + H(+) + NADH => a 2,3-saturated acyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30110", "l": "D-serine + NADP(+) <=> 2-aminomalonate semialdehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421831", "l": "trans-Golgi Network Coat Assembly (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22425", "l": "an S-alkyl-L-cysteine + H2O => an alkyl thiol + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203567", "l": "palmitoylation of eNOS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22695", "l": "3-hydroxybenzoate + H(+) + NADH + O2 <=> 2,5-dihydroxybenzoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665407", "l": "PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2106614", "l": "Duplex miRNA is loaded into Argonaute (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69053", "l": "RFC binding displaces Pol Alpha (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27761", "l": "(6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + CO2 + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265177", "l": "Exocyst complex formation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62808", "l": "H(+) + 2 julichrome Q6 + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + julichrome Q6-6 + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50634", "l": "a 2-(omega-methylsulfanyl)alkylmaleate + H2O => a 2-(omega-methylsulfanyl)alkylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-879459", "l": "F-actin capping protein is a heterodimer (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17722", "l": "a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60476", "l": "2 ATP + GTP = cyclic AMP-AMP-GMP + 3 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61871", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74986", "l": "Elongation of pre-rRNA transcript (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36915", "l": "(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354097", "l": "Activation of Talin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24004", "l": "butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878056", "l": "RUNX1:CBFB binds EP300 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16363", "l": "3-hydroxy-3-methyl-2-oxobutanoate => 2-acetolactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55575", "l": "4-hydoxytryptamine 4-phosphate + S-adenosyl-L-methionine <=> 4-hydroxy-N-methyltryptamine 4-phosphate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48965", "l": "2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 => [thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801762", "l": "REG3A oligomerize to form a pore complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47261", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.49"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62417", "l": "(E)-4-coumaroyl-CoA + H2O => 4-hydroxybenzaldehyde + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950782", "l": "p-STAT1 binds p-STAT3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37998", "l": "all-trans-nonaprenyl diphosphate + H(+) + homogentisate <=> 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16593", "l": "3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine = 3,3',4',5,7-pentahydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.88", "l": "\"8-hydroxyquercetin 8-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008390", "l": "testosterone 16-alpha-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.15"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5138432", "l": "DVL2 is phosphorylated by PKC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696266", "l": "RND2 binds effectors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052898", "l": "N1-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity"}, {"i": "RHEA:25864", "l": "H2O + N(1)-acetylspermidine + O2 = 4-acetamidobutanal + H2O2 + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28930", "l": "3,4,5-trihydroxybenzoate + O2 <=> (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250217", "l": "ARL2:GTP binds ARL2BP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781814", "l": "USP19 deubiquitinates RNF123 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39530", "l": "(2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH <=> (17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41628", "l": "geranylgeranyl diphosphate + H2O = cyclooctat-9-en-7-ol + diphosphate"}, {"i": "EC:4.2.3.146", "l": "\"Cyclooctat-9-en-7-ol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20567", "l": "(1S,2S,4R)-endo-fenchol + diphosphate => (2E)-geranyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59170", "l": "AMP + diphosphate + octadecanoyl-[(hydroxy)phthioceranic acid synthase] => ATP + holo-[(hydroxy)phthioceranic acid synthase] + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13043", "l": "5,6-dihydroxyindole-2-carboxylate => L-dopachrome"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55195", "l": "2-oxoglutarate + 3-methyldodecanoyl-CoA + O2 <=> 2-hydroxy-3-methyldodecanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27820", "l": "2-dehydro-L-idonate + H(+) + NADH => L-idonate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30175", "l": "15-cis-phytoene + 2 plastoquinone-9 = 9,9',15-tri-cis-zeta-carotene + 2 plastoquinol-9"}, {"i": "RHEA:30287", "l": "15-cis-phytoene + 2 a plastoquinone = 9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol"}, {"i": "EC:1.3.5.5", "l": "\"15-cis-phytoene desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43319", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28716", "l": "(R)-malate(in) + 2 H(+)(in) => (R)-malate(out) + 2 H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.-", "l": "\"In C-halide compounds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862700", "l": "CMKLR1 binds Resolvin E1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399711", "l": "Activation of Ca impermeable AMPA receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373734", "l": "Nephrin interacts with Podocin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000112", "l": "Endosomal TCII:Cbl translocates to lysosome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17045", "l": "1,2-bis-(3,4-dimethoxyphenyl)propane-1,3-diol + H2O2 = 1-(3,4-dimethoxyphenyl)ethane-1,2-diol + 3,4-dimethoxybenzaldehyde + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43791", "l": "acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O <=> ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54118", "l": "diphosphate + pseudolaratriene => (2E,6E,10E)-geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033421", "l": "CCU codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390276", "l": "4,8,12-trimethyltridecanoyl-CoA + 2 O2 + 2 H2O + 2 NAD+ + 2 CoASH => 4,8-dimethylnonanoyl-CoA + 2 H2O2 + 2 NADH + 2 H+ + acetyl-CoA + propionyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080123", "l": "jasmonate-amino synthetase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607023", "l": "factor IXa associates with cell membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16883", "l": "2 H(+) + sulfite + thiocyanate => hydrogen cyanide + thiosulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12792", "l": "an alditol + NADP(+) <=> an aldose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16882", "l": "hydrogen cyanide + thiosulfate => 2 H(+) + sulfite + thiocyanate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863494", "l": "ASICs bind STOML3, (STOM) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15953", "l": "agmatine + ATP = ADP + 2 H(+) + N(4)-phosphoagmatine"}, {"i": "EC:2.7.3.10", "l": "\"Agmatine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005344", "l": "oxygen carrier activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15401", "l": "dolichyl phosphate + UDP-alpha-D-glucose = dolichyl beta-D-glucosyl phosphate + UDP"}, {"i": "EC:2.4.1.117", "l": "\"Dolichyl-phosphate beta-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16471", "l": "(R)-2-benzylsuccinyl-CoA + succinate => (R)-2-benzylsuccinate + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004966", "l": "galanin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-372449", "l": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41952", "l": "2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate"}, {"i": "EC:2.6.1.118", "l": "\"[Amino group carrier protein]-gamma-(L-lysyl)-L-glutamate aminotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.45", "l": "\"E1 ubiquitin-activating enzyme\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29022", "l": "D-galactose(in) + H(+)(in) <=> D-galactose(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52818", "l": "an N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48942", "l": "2 an L-alpha-amino acid => an L-aminoacyl-L-amino acid + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41688", "l": "1-O-hexadecyl-2-propanoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954082", "l": "E2F6 binds the PRC1 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132085", "l": "Cleavage of C3 by surface-bound C3 convertases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654399", "l": "Activated FGFR2 binds FRS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59929", "l": "erythritol + NADP(+) => D-erythrose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51898", "l": "acetate + spermine => H2O + N(1)-acetylspermine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58431", "l": "(E,E)-2,4-hexadien-1-ol + NADP(+) <=> (E,E)-2,4-hexadienal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30581", "l": "L-threonine + phosphate => H2O + O-phospho-L-threonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66576", "l": "3'-phosphoadenylyl sulfate + 4-isopropylphenol = 4-isopropylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102738", "l": "(gibberellin-14), 2-oxoglutarate:oxygen oxidoreductase activity"}, {"i": "MetaCyc:RXN-7589"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55852", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA = [(2->6)-alpha-D-glucosyl-(1->4)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050172", "l": "phenylalanine 2-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55320", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = 2-heptanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl heptanoate + apo--[retinol-binding protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030788", "l": "precorrin-2 C20-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53499", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O <=> a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56121", "l": "2-all-trans-heptaprenylphenol + H(+) + NADPH + O2 => 3-(all-trans-heptaprenyl)benzene-1,2-diol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11461", "l": "ADP + D-glucose => AMP + D-glucose 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "75.582117822819498", "identifiers": [{"i": "GO:0015157", "l": "oligosaccharide transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0051864", "l": "histone H3-methyl-lysine-36 demethylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1980125", "l": "ITCH binds DTX (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74885", "l": "GUCYs converts GTP to cGMP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21906", "l": "(2R)-3-phosphoglycerate + phosphate => (2R)-2,3-bisphosphoglycerate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60243", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112156", "l": "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014456", "l": "GDIs block activation of RHOG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28126", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose = alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP"}, {"i": "EC:2.7.8.31", "l": "\"Undecaprenyl-phosphate glucose phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684261", "l": "MAP3K8 is phosphorylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0008301", "l": "DNA binding, bending"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62691", "l": "4 norrubrofusarin + O2 <=> 2 H2O + 2 ustilaginoidin A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43873", "l": "3-oxochol-4-en-22-oate + ATP + CoA => 3-oxochol-4-en-22-oyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034713", "l": "type I transforming growth factor beta receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64769", "l": "S-3-(hexan-1-ol)-L-cysteine => 2-aminoprop-2-enoate + 3-sulfanyl-1-hexanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63160", "l": "H2O + N-(15Z-tetracosenoyl)-taurine = (15Z)-tetracosenoate + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25660", "l": "(R)-menthofuran + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (R)-pulegone + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610720", "l": "PKA phosphorylates GLI3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50452", "l": "prostaglandin H3 = prostaglandin E3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42483", "l": "2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + catechol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.104"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45775", "l": "[(1->4)-beta-D-mannosyl](n) + phosphate <=> [(1->4)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66512", "l": "1-acyl-2-(9Z,12Z-octadecadienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090564", "l": "protein-phosphocysteine-glucose phosphotransferase system transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20607", "l": "NH4(+) + uracil => cytosine + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017128", "l": "phospholipid scramblase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53244", "l": "cholesta-5,7-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = cholesta-5,7-dien-3beta,24S-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34741", "l": "H(+) + N-acyl-15-methylhexadecasphing-4-enine + phosphocholine => H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66357", "l": "(5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + NAD(+) => (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2995330", "l": "COX10 transforms heme to heme O (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48994", "l": "1,3,7-trimethyl-5-hydroxyisourate + H2O + NAD(+) => 1,3,7-trimethylurate + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451366", "l": "Activation of p38MAPK by DSCAM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23273", "l": "an N(6)-alkylaminopurine + UDP-alpha-D-glucose => an N(6)-alkylamino-7-beta-D-glucosylpurine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37291", "l": "H2O + L-alanyl-L-leucine = L-alanine + L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51024", "l": "H(+) + NADH + O2 + toluene-4-sulfonate = 4-(hydroxymethyl)benzenesulfonate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36333", "l": "diphosphate + N(6)-(dimethylallyl)adenosine 5'-triphosphate => ATP + dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29052", "l": "2 H(+)(in) + H2 + menaquinone-8 => 2 H(+)(out) + menaquinol-8"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0003993", "l": "acid phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050154", "l": "opheline kinase activity"}, {"i": "MetaCyc:OPHELINE-KINASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785181", "l": "LMF1,2 bind LIPC dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25588", "l": "D-threo-isocitrate + NADP(+) = (S)-oxalosuccinate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062058", "l": "transcription factor TFIIH holo complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61979", "l": "glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950782", "l": "p-STAT1 binds p-STAT3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0019136", "l": "deoxynucleoside kinase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047475", "l": "phenylacetate-CoA ligase activity"}, {"i": "KEGG.REACTION:R02539"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47515", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH <=> isocholate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.2", "l": "\"(S)-2-haloacid dehalogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12262", "l": "ADP + H(+) + NADPH => ATP + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26008", "l": "beta-D-galacturonosyl di-trans,nona-cis-dodecaprenyl phosphate + UDP => di-trans,nona-cis-dodecaprenyl phosphate + UDP-alpha-D-galacturonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18149", "l": "H2O + N-acetyl-D-galactosamine 6-phosphate = acetate + D-galactosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63446", "l": "GMP + H(+) + oxidized coenzyme F420-0 => (2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205652", "l": "Pink1 recruits Parkin to the outer mitochondrial membrane. (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63819", "l": "ATP + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine + spermidine <=> AMP + diphosphate + H(+) + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432010", "l": "Aquaporin-1 passively transports water into cell (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193997", "l": "CYP11B1 oxidises 11DCORT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55438", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + salviol => ferruginol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59835", "l": "ATP + N(6)-(D-fructosyl)-L-lysyl-[protein] <=> ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65241", "l": "(11Z)-octadecenoyl-CoA + H2O => (11Z)-octadecenoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008294", "l": "calcium- and calmodulin-responsive adenylate cyclase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685603", "l": "SAP and EAT2 binds SLAMF6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33169", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycero-3-phospho-1D-myo-inositol => 2 a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34861", "l": "3-oxocyclopentanecarboxylate + NH4(+) => 3-oxocyclopentanecarbonitrile + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63033", "l": "a fatty acylamide + H2O => a fatty acid + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28530", "l": "H2O + XMP = phosphate + xanthosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375157", "l": "Interaction of NCAM1 with contactin-2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102029", "l": "D-lactate dehydrogenase (quinone) activity"}, {"i": "MetaCyc:DLACTDEHYDROGFAD-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0031779", "l": "melanocortin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19123", "l": "ADP + an S-substituted glutathione(out) + H(+) + phosphate => an S-substituted glutathione(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0001847", "l": "opsonin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013006", "l": "RHOA:GTP translocates to the ER membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27543", "l": "methanol + N,N-dimethyl-4-nitrosoaniline => 4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36509", "l": "3-oxotetracosanoyl-CoA + CO2 + CoA => docosanoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47001", "l": "H(+) + NADH + 2 NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] => NAD(+) + 2 NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60185", "l": "ATP + D-glucose(out) + H2O => ADP + D-glucose(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37956", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66264", "l": "ATP + H(+) + nonanoate = diphosphate + nonanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110311", "l": "POLZ extends translesion synthesis (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45472", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23950", "l": "H(+) + NADH + succinate semialdehyde => 4-hydroxybutanoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54275", "l": "2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2 <=> (3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51083", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10571", "l": "luteolin + UDP-alpha-D-glucuronate <=> H(+) + luteolin 7-O-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53935", "l": "O2 + prostaglandin I2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-prostaglandin I2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197958", "l": "FPGS-2 transforms THF to THFPG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.31.1", "l": "\"Micrococcal nuclease\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50225", "l": "3-(all-trans-hexaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.99.-", "l": "\"Miscellaneous\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52670", "l": "[amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH => [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56923", "l": "a medium chain fatty acid + ATP + H(+) <=> a medium-chain fatty acyl-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5669013", "l": "EDA-3 binds EDA2R (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030345", "l": "structural constituent of tooth enamel"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070878", "l": "primary miRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13924", "l": "ent-kaur-16-en-19-oate + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> gibberellin A12 aldehyde + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850831", "l": "KLK5 cleaves and activates KLK8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15860", "l": "17alpha,20alpha-dihydroxypregn-4-en-3-one + NADP(+) <=> 17alpha-hydroxyprogesterone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854222", "l": "TBC1D3 associates with RAB5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "66.785808001218697", "identifiers": [{"i": "GO:0005126", "l": "cytokine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59765", "l": "L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + octadecanoyl-CoA => CoA + H(+) + N(6)-octadecanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65481", "l": "2-methylbutanoyl-CoA + hexan-1-ol => CoA + hexyl 2-methylbutanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:1901479", "l": "benomyl transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187575", "l": "Ubiquitination of phospho-p27/p21 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23856", "l": "H(+) + Hg + NADP(+) = Hg(2+) + NADPH"}, {"i": "EC:1.16.1.1", "l": "\"Mercury(II) reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48446", "l": "a fatty acid + H(+) + long chain 2-acyl-3-O-beta-D-galactosyl-sn-glycerol => H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709406", "l": "CO binds to Cytochrome c oxidase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20251", "l": "D-alanine => L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202966", "l": "Caspase mediated cleavage of HIP-55 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13050", "l": "D-glucuronate => D-fructuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167118", "l": "NTP binds active site of RNA Polymerase II in HIV-1 open pre-initiation complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13252", "l": "(R)-2-hydroxypropyl-coenzyme M + NAD(+) <=> 2-oxopropyl-coenzyme M + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32194", "l": "H2O + L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-oxoglutarate + 2 H(+) + NH4(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955869", "l": "Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38838", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72185", "l": "mRNA polyadenylation (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66883", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 10-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64001", "l": "(4R)-hydroxysphinganine + octadecanoyl-CoA => CoA + H(+) + N-octadecanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43876", "l": "3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oate + ATP + CoA = 3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45279", "l": "12-phosphooxy-(9E)-octadecenoate + H2O <=> 12-hydroxy-(9E)-octadecenoate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008939", "l": "nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15721", "l": "glycine + H2O + NAD(+) = glyoxylate + H(+) + NADH + NH4(+)"}, {"i": "EC:1.4.1.10", "l": "\"Glycine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429157", "l": "ABCC4 accumulation of dense granule contents (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75079", "l": "Formation of AT-AC C complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444647", "l": "C3a receptor binds anaphylatoxin C3a (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15768", "l": "adenosylcob(III)inamide + GTP <=> adenosylcob(III)inamide phosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429694", "l": "CERT:PPM1L:VAPA/B [ER] => CERT [cytosol] + PPM1L:VAPA/B [ER] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981610", "l": "Neuroglobin binds oxygen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0099100", "l": "G-protein gated cation channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015624", "l": "ABC-type ferric-enterobactin transporter activity"}, {"i": "MetaCyc:ABC-10-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714483", "l": "RAC2 translocates to the ER membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18824", "l": "acetyl-CoA + choline <=> acetylcholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24302", "l": "2 cob(II)yrinate a,c diamide + FMNH2 => 2 cob(I)yrinate a,c diamide + FMN + 3 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41461", "l": "1,2-diacyl-glycero-3-phosphocholine + an N-acylsphing-4-enine => a 1,2-diacylglycerol + a sphingomyelin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186765", "l": "PLC-gamma binds to the active receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41593", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9724290", "l": "GNRHR2 binds GNRH1,2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098650", "l": "peptidyl-proline 4-dioxygenase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601926", "l": "RNA polymerase II polymerizes primary piRNA transcript (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674019", "l": "BRAP binds KSR1:MARK3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605797", "l": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202129", "l": "HSP90 binds eNOS:Caveolin-1:CaM complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10067", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + D-alanine + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40092", "l": "26-hydroxyhexacosanoate + NAD(+) => 26-oxohexacosanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51764", "l": "dimethylallyl diphosphate + phlorisovalerophenone = 4-prenylphlorisovalerophenone + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26469", "l": "a 2-demethylmenaquinone + S-adenosyl-L-methionine <=> a menaquinone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001596", "l": "angiotensin type I receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.41", "l": "\"Atrolysin B\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869543", "l": "TFPA2A homodimer and NPM1 bind the NOP2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30636", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate => alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.24.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36295", "l": "alpha-maltose 6'-phosphate + H2O = D-maltose + phosphate"}, {"i": "EC:3.1.3.90", "l": "\"Maltose 6'-phosphate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030563", "l": "snRNA 2'-O-ribose methylation guide activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35427", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside = cyanidin 3,5-di-O-beta-D-glucoside + E-sinapate"}, {"i": "EC:2.4.1.299", "l": "\"Cyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75146", "l": "TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19326", "l": "H(+) + NADH + O2 + quinolin-4-ol => H2O + NAD(+) + quinoline-3,4-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59164", "l": "ATP + hexadecanoate + holo-[(hydroxy)phthioceranic acid synthase] = AMP + diphosphate + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]"}, {"i": "RHEA:59168", "l": "ATP + holo-[(hydroxy)phthioceranic acid synthase] + octadecanoate = AMP + diphosphate + octadecanoyl-[(hydroxy)phthioceranic acid synthase]"}, {"i": "EC:6.2.1.57", "l": "\"Long-chain fatty acid adenylase/transferase FadD23\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450494", "l": "HuR binds mRNAs in the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708466", "l": "BACH1 translocates from the nucleoplasm to the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49743", "l": "2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate <=> CO2 + deoxyviolacein + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865774", "l": "TTLLs polyglutamylate tubulin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50853", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43585", "l": "H2O + iminoarginine => 5-guanidino-2-oxopentanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004657", "l": "proline dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798748", "l": "Exocytosis of secretory granule lumen proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12336", "l": "carboxymethoxysuccinate = fumarate + glycolate"}, {"i": "EC:4.2.99.12", "l": "\"Carboxymethyloxysuccinate lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247844", "l": "WNT ligands traffic to the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17856", "l": "keto-L-sorbose + O2 <=> 5-dehydro-D-fructose + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17691", "l": "adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate + H(+) => 3'-phosphoadenylyl sulfate + glycochenodeoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35782", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> mutildienyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10219", "l": "[DNA-directed RNA polymerase] + ATP <=> ADP + H(+) + phospho-[DNA-directed RNA polymerase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54876", "l": "(4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one = (3S)-3-isopropenyl-6-oxoheptanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60787", "l": "2-oxoglutarate + gibberellin A24 + O2 <=> CO2 + gibberellin A25 + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381158", "l": "ATF6:HSPA5 (ATF6-alpha:BiP) dissociates and HSPA5 binds unfolded protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65141", "l": "AH2 + O2 + protoaustinoid A => A + berkeleyone A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660503", "l": "Expression of CSRP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24601", "l": "H2O + O2 + sulfite => H2O2 + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3857336", "l": "CEBPB homodimerization (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41375", "l": "1-O-dodecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-dodecyl-sn-glycero-3-phosphocholine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55022", "l": "5,6-diaminouracil + D-ribose 5-phosphate => 5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49751", "l": "2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate <=> CO2 + 2 H2O + NADP(+) + proviolacein"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008742", "l": "L-ribulose-phosphate 4-epimerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004808", "l": "tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity"}, {"i": "RHEA:19569", "l": "5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine = 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.61", "l": "\"tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035049", "l": "juvenile hormone acid methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635915", "l": "ATF4 and CEBPB,CEBPG bind the ASNS gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18023", "l": "CMP + ganglioside GD1a (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E))"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48706", "l": "12S-HpEPE => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0050997", "l": "quaternary ammonium group binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.25"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10049", "l": "methanethiol + O-acetyl-L-homoserine => acetate + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2130151", "l": "Dimerization of DAP12 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64164", "l": "2-methyl-L-serine = formaldehyde + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57898", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19130", "l": "ATP + thymidine => ADP + dTMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22236", "l": "2-deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate"}, {"i": "EC:3.1.3.68", "l": "\"2-deoxyglucose-6-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45934", "l": "4-hydroxy-6-(3-methyl-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA => 2-methylhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33351", "l": "hexacosanoyl-CoA + sphinganine = CoA + H(+) + N-hexacosanoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35630", "l": "delphinidin 3,5-bis-O-beta-D-glucoside + UDP-alpha-D-glucose <=> delphinidin 3,3',5-tri-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64131", "l": "H2O + N-octadecanoyl-L-phenylalanine <=> L-phenylalanine + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003923", "l": "GPI-anchor transamidase activity"}, {"i": "REACT:R-HSA-162836", "l": "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43029", "l": "L-cysteate => 2-aminoprop-2-enoate + H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22224", "l": "3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA = 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O"}, {"i": "EC:2.3.1.159", "l": "\"Acridone synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047251", "l": "thiohydroximate beta-D-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202459", "l": "Phosphorylation of Bcl10 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13117", "l": "O-acetyl-L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + acetate + H(+)"}, {"i": "EC:2.5.1.51", "l": "\"Beta-pyrazolylalanine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40343", "l": "3-oxohexadecanedioyl-CoA + CoA = acetyl-CoA + tetradecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37866", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA <=> 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33616", "l": "ATP + CoA + octadecanoate => AMP + diphosphate + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-976768", "l": "Factor H binds to C3b (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9612219", "l": "ERBB4s80 binds to SRC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-182594", "l": "Association of INK4 family proteins with CDK4/6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37868", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA => 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694428", "l": "LMAN family proteins bind glycosylated cargo (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26503", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP-alpha-D-glucose => 2 H(+) + ternatin C5 + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662466", "l": "XYLB phosphorylates D-xylulose (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57302", "l": "a 2'-deoxyguanosine in DNA + H(+) + lactate => an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.23"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23471", "l": "2-aminobenzenesulfonate + 2 H(+) + NADH + O2 <=> 2,3-dihydroxybenzenesulfonate + NAD(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-378956", "l": "Luteinizing hormone is a heterodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46619", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35125", "l": "H(+)(in) + L-alanyl-D-glutamate(in) => H(+)(out) + L-alanyl-D-glutamate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6813749", "l": "ALDH1A1 oxidises GA to DGA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49300", "l": "D-maltose(out) + N(pros)-phospho-L-histidyl-[protein] = alpha-maltose 6'-phosphate(in) + L-histidyl-[protein]"}, {"i": "EC:2.7.1.208", "l": "\"Protein-N(pi)-phosphohistidine--maltose phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034956", "l": "diphenyl ether 1,2-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12935", "l": "(S)-lactaldehyde + dihydroxyacetone phosphate => L-fuculose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11457", "l": "N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031730", "l": "CCR5 chemokine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139906", "l": "Activation of BAD by calcineurin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32916", "l": "sn-glycero-3-phospho-1D-myo-inositol(out) => sn-glycero-3-phospho-1D-myo-inositol(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30498", "l": "N-hydroxy-L-valine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37386", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62031", "l": "H2O + stigmasteryl 3-beta-D-glucoside <=> D-glucose + stigmasterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50737", "l": "a quinone + 2 H(+) + hydrogen sulfide + sulfite => a quinol + thiosulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55192", "l": "2-oxoglutarate + 3-methyldodecanoyl-CoA + O2 = 2-hydroxy-3-methyldodecanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389381", "l": "Gads binds CD28 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856525", "l": "ANGPTL8 binds ANGPTL3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18100", "l": "pteridine-2,4,6,7-tetrol <=> H(+) + xanthine-8-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212352", "l": "Formation of ARC coactivator complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41325", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 => (12S)-hydroperoxy-(5Z,8Z,10E)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66398", "l": "ADP + cholate(out) + glutathione(out) + H(+) + phosphate => ATP + cholate(in) + glutathione(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42303", "l": "a fatty acyl-[ACP] + sn-glycerol 3-phosphate <=> a 1-acyl-sn-glycero-3-phosphate + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58566", "l": "15alpha-stemmadenine intermediate II + 2 H(+) + NADPH => 15alpha-stemmadenine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034570", "l": "hydroxymonomethylisoproturon dimethylaminedehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700120", "l": "PTN and MDK bind to PTPRZ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114264", "l": "Translocation of activated BAX to the mitochondria (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13958", "l": "4 H2O + O2 + 4 sulfur => 6 H(+) + 2 hydrogen sulfide + 2 sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782943", "l": "UV-DDB ubiquitinates XPC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26346", "l": "L-galactonate + NADP(+) => aldehydo-D-galacturonate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1605797", "l": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-114683", "l": "Phosphorylation of Platelet Sec-1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34089", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a cholesterol ester => a 1,2-diacyl-sn-glycero-3-phosphocholine + cholesterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59046", "l": "(20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + H(+) + UDP => dammarenediol-II + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47777", "l": "guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(1145) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58719", "l": "FADH2-C4alpha-hydroperoxide + NADH + rifampicin <=> FADH2 + H(+) + H2O + NAD(+) + rifampicin hemiaminal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043768", "l": "S-ribosylhomocysteine lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025998", "l": "Epoxide hydrolase hydrolyses 13,14-epoxy-DPAn-3 to MaR1n-3 DPA or MaR2n-3 DPA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17374", "l": "all-trans-antheraxanthin => all-trans-capsanthin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16268", "l": "O2 + reduced [NADPH--hemoprotein reductase] + trans-5-O-(4-coumaroyl)-D-quinate <=> 5-O-[(E)-caffeoyl]-D-quinate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15997", "l": "anthraniloyl-CoA + 2 H(+) + 2 NADH + O2 = 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62056", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose = alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033784", "l": "senecionine N-oxygenase activity"}, {"i": "MetaCyc:1.14.13.101-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38938", "l": "cyclohexane-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> cyclohex-1-ene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30225", "l": "2 [Fe(II)cytochrome c] + H(+) + sulfur => 2 [Fe(III)cytochrome c] + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20354", "l": "A + chloride + H(+) + trichloroethene => AH2 + tetrachloroethene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39430", "l": "(2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH <=> (23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879594", "l": "SLCO4C1 mediates the transport of digoxin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56779", "l": "(+)-pinoresinol + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-piperitol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32972", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + 2 H2O => 2 a carboxylate + 2 H(+) + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788867", "l": "FN3K phosphorylates ketosamines (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19586", "l": "lithocholate + NAD(+) => 3-oxo-5beta-cholan-24-oate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55939", "l": "all-trans-4-hydroxyretinol + NAD(+) <=> all-trans-4-hydroxyretinal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051116", "l": "cobaltochelatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62726", "l": "(+)-isomalbrancheamide C + FADH2 => (+)-premalbrancheamide + bromide + FAD + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655336", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396395", "l": "HSPG2 (perlecan) binds alpha-dystroglycan (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5686578", "l": "Activated ATM phosphorylates ABL1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62480", "l": "1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O = 2-glutaroyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879907", "l": "Tyrosine kinases phosphorylate the receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961961", "l": "E2F1 binds the CDC25A gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38516", "l": "1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000822", "l": "inositol hexakisphosphate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36008", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42515", "l": "5-acetamidopentanoate + H2O <=> 5-aminopentanoate + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43700", "l": "(2E,6E)-farnesoate + S-adenosyl-L-methionine = methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine"}, {"i": "RHEA:43720", "l": "juvenile hormone III carboxylate + S-adenosyl-L-methionine = juvenile hormone III + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.325", "l": "\"Juvenile hormone-III synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46137", "l": "aminopyrrolnitrin + H(+) + NADPH + 2 O2 => 2 H2O + NADP(+) + pyrrolnitrin"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0004939", "l": "beta-adrenergic receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57366", "l": "(6S)-NADHX => H2O + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40815", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33952", "l": "ribostamycin + UDP-N-acetyl-alpha-D-glucosamine => 2'''-acetyl-6'''-hydroxyneomycin C + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27785", "l": "4-hydroxybenzoate + all-trans-octaprenyl diphosphate <=> 4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34048", "l": "6'''-deamino-6'''-hydroxyneomycin C + O2 => 6'''-deamino-6'''-oxoneomycin C + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38873", "l": "pseudouridine(2457) in 23S rRNA => uridine(2457) in 23S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187678", "l": "ADCYAP1(2-742) binds ADCYAP1R1 and NTRK1,2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024159", "l": "FTSJ1 2'-O-methylates cytidine-32 in tRNA(Phe) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12637", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose = (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP"}, {"i": "EC:2.4.1.50", "l": "\"Procollagen galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31738", "l": "3-oxocholan-24-oyl-CoA + NAD(+) <=> 3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64966", "l": "dUMP + 2 H(+) + 2 phosphate => dUTP + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-870269", "l": "Gastrin binds to CCK-B receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.44", "l": "\"(R)-dichlorprop dioxygenase (2-oxoglutarate)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-179421", "l": "Degradation of multiubiquitinated Nek2A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-417890", "l": "P2Y5 receptor can bind to LPA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877941", "l": "RUNX2 binds SMAD1 in the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38430", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O <=> 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682011", "l": "LC3 binds ATG7 dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198621", "l": "AKT phosphorylates caspase-9 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63754", "l": "carminate + 2 H(+) + UDP => kermesate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45952", "l": "L-asparaginyl-[protein] + UDP-alpha-D-glucose = H(+) + N(4)-(beta-D-glucosyl)-L-asparaginyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65136", "l": "(9Z)-octadecenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25933", "l": "4-methylquinoline + A + H2O => 4-methylquinolin-2(1H)-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18403", "l": "(S)-4-hydroxymandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-4-hydroxyphenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36241", "l": "1-O-alkyl-2-acyl-sn-glycerol + phosphate => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31535", "l": "2-oxoglutarate + L-arginine + O2 = (S)-1-pyrroline-5-carboxylate + CO2 + guanidine + H(+) + H2O + succinate"}, {"i": "EC:1.14.20.7", "l": "\"2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.111", "l": "\"2-oxoglutaramate amidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22602", "l": "acetate + H(+) + N-acetylneuraminate => H2O + N-acetyl-9-O-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874080", "l": "SRC phosphorylates PTK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047157", "l": "myelin-proteolipid O-palmitoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102291", "l": "11alpha-hydroxy-beta-amyrin dehydrogenase activity"}, {"i": "RHEA:31719", "l": "11alpha-hydroxy-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 11-oxo-beta-amyrin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57881", "l": "3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-alpha-D-xylose => 3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32802", "l": "urea(in) <=> urea(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678327", "l": "MIOX oxidises Ins to GlcA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990224", "l": "NMN phosphatase activity"}, {"i": "RHEA:30815", "l": "beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinamide D-riboside + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41565", "l": "aklavinone + dTDP-beta-L-rhodosamine => aclacinomycin T + dTDP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592243", "l": "Expression of POLRMT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23034", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate => 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.45"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983150", "l": "Proteasomal cleavage of substrate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351208", "l": "Spermidine  => N-acetylated spermidine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849094", "l": "ARHGAP35 binds RASA1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10990", "l": "2 e(-) + 2 H(+) + 2 nitric oxide => H2O + nitrous oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682826", "l": "LGI1 binds ADAM11 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000433", "l": "SUMOylation of PML with SUMO3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051989", "l": "coproporphyrinogen dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052625", "l": "4-aminobenzoate amino acid synthetase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44027", "l": "(3R)-3-hydroxydodecanoyl-CoA <=> (2E)-dodecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209303", "l": "LGS transports from the nucleus to the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-500708", "l": "GRIK3 homomer binds glutamate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28390", "l": "N(6)-(D-psicosyl)-L-lysine = N(6)-(D-fructosyl)-L-lysine"}, {"i": "EC:5.1.3.41", "l": "\"Fructoselysine 3-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034768", "l": "(E)-beta-ocimene synthase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "68.763737436043385", "identifiers": [{"i": "GO:0019899", "l": "enzyme binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112037", "l": "Inactivation of PLC beta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60415", "l": "H2O + monoglucosyl-enterobactin <=> [N-(2,3-dihydroxybenzoyl)-L-seryl]2-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10686", "l": "L-tyrosyl-[protein] + phosphate => H2O + O-phospho-L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45969", "l": "androst-4-ene-3,17-dione + H(+) + NADH + O2 => 9alpha-hydroxy-androst-4-ene-3,17-dione + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374665", "l": "DCC interaction with SIAH1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10018", "l": "choline + E-sinapate + H(+) => H2O + O-sinapoylcholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63068", "l": "acetyl-CoA + 2 H(+) + 2 malonyl-CoA = 2 CO2 + 3 CoA + triacetate lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19204", "l": "2'-deoxyguanosine + ATP <=> ADP + dGMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46797", "l": "2 [Fe(II)-cytochrome b5] + an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36933", "l": "(9Z)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => 2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047156", "l": "acetoin-ribose-5-phosphate transaldolase activity"}, {"i": "RHEA:21504", "l": "acetoin + aldehydo-D-ribose 5-phosphate = 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde"}, {"i": "EC:2.2.1.4", "l": "\"Acetoin--ribose-5-phosphate transaldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005163", "l": "nerve growth factor receptor binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004342", "l": "glucosamine-6-phosphate deaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30258", "l": "2 a ubiquinol + O2 <=> 2 a ubiquinone + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380780", "l": "Activation of Src (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050156", "l": "ornithine N-benzoyltransferase activity"}, {"i": "RHEA:16929", "l": "2 benzoyl-CoA + L-ornithine = 2 CoA + 2 H(+) + N(2),N(5)-dibenzoyl-L-ornithine"}, {"i": "EC:2.3.1.127", "l": "\"Ornithine N-benzoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57452", "l": "L-glutaminyl-[protein] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050634", "l": "phloroisovalerophenone synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29473", "l": "D-ribose + phosphate => D-ribose 5-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592398", "l": "Activation of proMMP8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32516", "l": "(4S,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O => (3S,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373746", "l": "SEMA4D interacts with CD45 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41297", "l": "hexanoate + sphing-4-enine => H2O + N-(hexanoyl)sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65010", "l": "decanoyl-AMP + diphosphate => ATP + decanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205231", "l": "Dimerization of KIT upon SCF binding (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5651828", "l": "PARG dePARylates PARP1,PARP2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31740", "l": "a 4'-hydroxyisoflavone + S-adenosyl-L-methionine => a 4'-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450494", "l": "HuR binds mRNAs in the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17393", "l": "3-maleylpyruvate = 3-fumarylpyruvate"}, {"i": "EC:5.2.1.4", "l": "\"Maleylpyruvate isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49156", "l": "dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine = dTDP-alpha-D-forosamine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008656", "l": "cysteine-type endopeptidase activator activity involved in apoptotic process"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58987", "l": "acrolein + H2O + O2 <=> acrylate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018597", "l": "ammonia monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429157", "l": "ABCC4 accumulation of dense granule contents (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209111", "l": "Translation of p14ARF mRNA is inhibited by miR-24 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45450", "l": "dodecanoate + sphinganine => H2O + N-(dodecanoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0089720", "l": "caspase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113402", "l": "Formation of DSIF:NELF:early elongation complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65852", "l": "a 3-oxo-Delta(1)-steroid + H2O = a 1-hydroxy-3-oxo steroid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29509", "l": "(-)-alpha-gurjunene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46818", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156930", "l": "GTP-binding activates eEF2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592362", "l": "Activation of proMMP7 by MMP3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928641", "l": "PAK binds RAC and bPIX (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654651", "l": "Activated FGFR4 binds FRS3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29875", "l": "H2O + sn-glycero-3-phospho-L-serine = H(+) + L-serine + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43001", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55742", "l": "D-glucose + oleuropein aglycone => H2O + oleuropein"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16088", "l": "ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036319", "l": "mating-type M-factor pheromone receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2562526", "l": "PLK1 phosphorylates OPTN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29211", "l": "H(+)(out) + inosine(in) = H(+)(in) + inosine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419426", "l": "Cannabinoid receptors can bind cannabinoids (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0016414", "l": "O-octanoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16711", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52001", "l": "a 1-(methylsulfanyl)-4-aci-nitroalkane + glutathione => an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83656", "l": "TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200646", "l": "Cytosolic folate export across the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661474", "l": "Defective NPC does not transport GCK1:GKRP from cytosol to nucleoplasm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618331", "l": "HDAC6 deacetylates microtubules (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62577", "l": "ATP + H2O + L-cystine(out) => ADP + H(+) + L-cystine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62136", "l": "dGMP + GTP = dGDP + GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27928", "l": "UMP(out) => UMP(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19712", "l": "a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27342", "l": "AH2 + NH4(+) + O2 => A + H(+) + H2O + hydroxylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429036", "l": "SLC2A9 transports Fru, Glc, urate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16156", "l": "an aliphatic amine + H2O + O2 <=> an aldehyde + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43829", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45029", "l": "(2S)-methylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => 2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534378", "l": "Hv1 Mediated H+ Permeability (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047072", "l": "2,3-dihydroxybenzoate 2,3-dioxygenase activity"}, {"i": "KEGG.REACTION:R01506"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660980", "l": "p-S276-RELA binds RELB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030746", "l": "isoflavone 4'-O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31543", "l": "all-trans-zeaxanthin + 2 UDP-alpha-D-glucose = 2 H(+) + 2 UDP + zeaxanthin bis(beta-D-glucoside)"}, {"i": "EC:2.4.1.276", "l": "\"Zeaxanthin glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38023", "l": "gamma-tocotrienol = 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39543", "l": "3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13323", "l": "3-methyl-2-oxobutanoate + CO2 + NADH => (R)-3,3-dimethylmalate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16323", "l": "H(+) + indan-1-one + NADPH => (S)-indan-1-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56069", "l": "an N-acetyl-alpha-D-glucosaminyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-76031", "l": "2 H2O2 => O2 + 2 H2O (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66987", "l": "3-methylbutanoyl-CoA + H2O <=> CoA + H(+) + isovalerate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58492", "l": "ATP + Fe(III)-enterobactin(out) + H2O = ADP + Fe(III)-enterobactin(in) + H(+) + phosphate"}, {"i": "EC:7.2.2.17", "l": "\"ABC-type ferric enterobactin transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9649735", "l": "Intrinsic nucleotide exchange on RAS (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004994", "l": "somatostatin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626699", "l": "MARK4 binds ODF2 in the centriole (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46593", "l": "alfacalcidol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => calcitriol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16252", "l": "alpha-D-glucose 6-phosphate <=> beta-D-glucose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14359", "l": "ADP + FMN + H(+) => ATP + riboflavin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28427", "l": "D-allulose 6-phosphate => keto-D-fructose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30868", "l": "H2O + indole-3-acetaldehyde + NAD(+) => (indol-3-yl)acetate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59177", "l": "ADP + L-serine => AMP + H(+) + O-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191763", "l": "snRNP:Snurportin complex formation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0033744", "l": "L-methionine:thioredoxin-disulfide S-oxidoreductase activity"}, {"i": "KEGG.REACTION:R07606"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903877", "l": "21-deoxycortisol binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13839", "l": "4,5-dihydroxyphthalate + H(+) + NADH => cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683653", "l": "Spike protein gets palmitoylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49794", "l": "CoA + H(+) + N-eicosanoylglycinate => eicosanoyl-CoA + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36576", "l": "(9Z)-octadecenoyl-CoA + sphinganine => CoA + H(+) + N-(9Z-octadecenoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174706", "l": "chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "59.423266100611116", "identifiers": [{"i": "GO:0140098", "l": "catalytic activity, acting on RNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4837364", "l": "Secretion of SOD3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.422", "l": "\"Pseudoephedrine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41295", "l": "H2O + N-(hexanoyl)sphing-4-enine = hexanoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41082", "l": "1-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56912", "l": "(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + H2O + NAD(+) = (E)-2-((N-methylformamido) methylene)succinate + 3 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51388", "l": "acetyl-CoA + dopamine = CoA + H(+) + N-acetyl-dopamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24366", "l": "2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50132", "l": "ethyl hexadecanoate + H2O = ethanol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429694", "l": "CERT:PPM1L:VAPA/B [ER] => CERT [cytosol] + PPM1L:VAPA/B [ER] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12015", "l": "ATP + thiamine <=> ADP + H(+) + thiamine phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120233", "l": "prenyl-FMNH2 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27765", "l": "CTP + H2O <=> CMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36372", "l": "(2S)-hydroxybutanoate + NAD(+) => 2-oxobutanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60951", "l": "(S)-eriodictyol + S-adenosyl-L-methionine <=> (S)-homoeriodictyol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13917", "l": "(-)-menthol + NADP(+) = (1R,4S)-menthone + H(+) + NADPH"}, {"i": "EC:1.1.1.207", "l": "\"(-)-menthol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38450", "l": "4-O-(beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + H2O <=> 4-O-(beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034073", "l": "tetrahymanol cyclase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16967", "l": "beta-myrcene + diphosphate => (2E)-geranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45580", "l": "D-galactaro-1,5-lactone = D-galactaro-1,4-lactone"}, {"i": "EC:5.4.1.4", "l": "\"D-galactarolactone isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43225", "l": "(24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => (24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28741", "l": "Cd(2+)(out) + H(+)(in) => Cd(2+)(in) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63845", "l": "[thioredoxin]-dithiol + cumene hydroperoxide => 2-phenylpropan-2-ol + [thioredoxin]-disulfide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168644", "l": "CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45483", "l": "gamma-hexachlorocyclohexane <=> (3R,4S,5S,6R)-pentachlorocyclohexene + chloride + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20314", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP => 1D-myo-inositol hexakisphosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12954", "l": "ATP + L-seryl-[Goodpasture antigen-binding protein] => ADP + H(+) + O-phospho-L-seryl-[Goodpasture antigen-binding protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21362", "l": "diphosphate + NAD(+) => ATP + beta-nicotinamide D-ribonucleotide + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59129", "l": "(S)-2,3-diaminopropanoate + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + ATP => 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665727", "l": "FMNL2 binds CDC42:GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45877", "l": "2-methylhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 6-(hexadecan-2-yl)-4-hydroxy-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14330", "l": "2-oxoglutarate + O-phospho-L-serine => 3-phosphooxypyruvate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16366", "l": "digallate + H2O => 2 3,4,5-trihydroxybenzoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5679205", "l": "ULK1 phosphorylates Beclin-1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199131", "l": "PVR binds CD226 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794338", "l": "GKAPs bind PSD-95 members (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9664867", "l": "NBR1 binds MAP1LC3B (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63581", "l": "20-hydroxyecdysone 22-phosphate + H2O => 20-hydroxyecdysone + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0019144", "l": "ADP-sugar diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24595", "l": "CTP + H(+) + phosphoethanolamine <=> CDP-ethanolamine + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799409", "l": "HIPK2 phosphorylates TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45708", "l": "3-dehydrocarnitine + acetyl-CoA = 3-dehydrocarnityl-CoA + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19891", "l": "diphosphate + UDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + H(+) + UTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45625", "l": "ATP + holo-[CmaA peptidyl-carrier protein] + L-alloisoleucine => AMP + diphosphate + L-alloisoleucyl-[CmaA peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443831", "l": "14-3-3-zeta binds Raf1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698005", "l": "FLT3 ITD mutants phosphorylate STAT5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23955", "l": "H2O + N-(2-phenylethyl)acetamide <=> 2-phenylethylamine + acetate"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004897", "l": "ciliary neurotrophic factor receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2889070", "l": "SLC9B2 exchanges Na+, Li+ for H+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692764", "l": "MAPK6 binds CCND3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55659", "l": "2 A + a carotenoid beta-end derivative <=> a carotenoid chi-end derivative + 2 AH2"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0003995", "l": "acyl-CoA dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626953", "l": "TNF-alpha:TNFR1 binds DENN/MADD (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32235", "l": "(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70692", "l": "ornithine => putrescine + CO2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27405", "l": "a ubiquinone + H2O + pyruvate = a ubiquinol + acetate + CO2"}, {"i": "EC:1.2.5.1", "l": "\"Pyruvate dehydrogenase (quinone)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029521", "l": "NR1H2,3 binds the ABCG5 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617829", "l": "Assembly of IFT A complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061759", "l": "alpha-ketoglutarate reductase activity"}, {"i": "RHEA:21254", "l": "2-oxoglutarate + AH2 => (S)-2-hydroxyglutarate + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534240", "l": "HSPG2 (perlecan) degradation by MMP14, MMP15 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3134954", "l": "DHX9 binds DNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450494", "l": "HuR binds mRNAs in the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45586", "l": "(2E)-butenoyl-CoA + H2O => 3-hydroxybutanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41166", "l": "1-O-hexadecyl-2-amino-sn-glycerol + ATP <=> 1-O-hexadecyl-2-desoxy-2-amino-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047924", "l": "geraniol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015547", "l": "nalidixic acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806629", "l": "Formation of tonofilament bundles (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202241", "l": "Recruitment of SLP-76 to Gads (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45988", "l": "3,17-dihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMNH2 + O2 = 3,4,17-trihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMN + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30281", "l": "3 H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2 + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692781", "l": "p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166214", "l": "FA anion flip-flops to the opposite surface (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.14", "l": "\"Glucuronan lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448963", "l": "Interaction of MyoD:E protein with MEF2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985929", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211948", "l": "CYP3A4 can N-demethylate loperamide (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58007", "l": "(20S)-ginsenoside F2 + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rd + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66796", "l": "miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 11-oxomiltiradiene + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61532", "l": "ent-kaur-16-ene + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = ent-kaur-16-en-19-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45556", "l": "H2O + N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-dodecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39967", "l": "2-aminobut-2-enoate = 2-iminobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396370", "l": "VTN binds collagens II, III and V (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.39", "l": "\"Xyloglucan 6-xylosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10400", "l": "L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine"}, {"i": "EC:2.6.1.15", "l": "\"Glutamine--pyruvate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47262", "l": "16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + progesterone + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612085", "l": "SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666049", "l": "SRF:MKL1 stimulate ITGB1 expression while SCAI inhibits it (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661230", "l": "MT1A binds arsenic (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013438", "l": "RHOD binds effectors at the endosome membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60155", "l": "H2O + L-gamma-glutamyl-L-glutamyl-[protein] <=> L-glutamate + L-glutamyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417896", "l": "P2Y6 receptor can bind to UDP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2002460", "l": "P4HB binds Collagen chains (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948063", "l": "hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49533", "l": "4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O => ethylene glycol + H(+) + terephthalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5666008", "l": "SCAI binds SRF:MKL1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38347", "l": "(S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate = 2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate"}, {"i": "EC:2.6.1.103", "l": "\"(S)-3,5-dihydroxyphenylglycine transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37308", "l": "glycyl-L-asparagine + H2O => glycine + L-asparagine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917696", "l": "Cargo Sequestration (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202500", "l": "Activation of IKK complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38436", "l": "(9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944223", "l": "Association of procollagen type V (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64656", "l": "(E)-sinapoaldehyde + CoA + NADP(+) = (E)-sinapoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607756", "l": "TRAF6 oligomer autoubiquitinates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5251942", "l": "Hikeshi binds HSP70s:ATP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20799", "l": "aldehydo-D-ribose <=> D-ribulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50902", "l": "(10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate => 10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784189", "l": "JAKs bind LIFR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42530", "l": "pseudouridine(955/2504/2580) in 23S rRNA => uridine(955/2504/2580) in 23S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42813", "l": "cholesterol + octadecanoyl-CoA => cholesteryl octadecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5618107", "l": "ATP binding to HSP90 triggers conformation change (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429815", "l": "Formation Of Bloc-1 Complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35744", "l": "H(+) + NADPH + O2 + versicolorin B => 2 H2O + NADP(+) + versicolorin A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27675", "l": "ATP + dADP => ADP + dATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24944", "l": "1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NADP(+) => 4-hydroxy-L-glutamate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851436", "l": "CFHR dimers bind C3b (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635842", "l": "ULK3 phosphorylates GLI (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48610", "l": "a 2,3-dehydroacyl-CoA + AH2 => A + a 2,3-saturated acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64135", "l": "H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-L-phenylalanine <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47721", "l": "H(+) + H2O + isoguanine => NH4(+) + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682020", "l": "MRN complex binds shortened telomeres (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110307", "l": "REV1 binds AP-dsDNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209361", "l": "STAT92E binds to phosphorylated HOP and phosphorylated DOME (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042500", "l": "aspartic endopeptidase activity, intramembrane cleaving"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3645780", "l": "TGFBR2 KD mutants do not phosphorylate TGFBR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070984", "l": "SET domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42290", "l": "(S)-8-amino-7-oxononanoate + CO2 + holo-[ACP] => 6-carboxyhexanoyl-[ACP] + H(+) + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20049", "l": "1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide"}, {"i": "EC:3.5.4.19", "l": "\"Phosphoribosyl-AMP cyclohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61409", "l": "ATP + N(6)-(D-erythrulosyl)-L-lysine => ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72127", "l": "Formation of the Spliceosomal B Complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202702", "l": "CD177 binds PECAM-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39744", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14650", "l": "demethyllactenocin + dTDP-beta-L-mycarose => demethylmacrocin + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57106", "l": "4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-2) => [(1->4)-alpha-D-galacturonosyl](n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30625", "l": "AH2 + all-trans-lycopene => A + all-trans-neurosporene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709842", "l": "MAVS binds TOMM70 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39060", "l": "26-hydroxyhexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 26-oxohexacosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-917700", "l": "MVB Vesicle Formation (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43958", "l": "H2O + NADP(+) + omega-hydroxy-15-methyl-hexadecanoate => 15-methylhexadecanoate + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0051998", "l": "protein carboxyl O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23570", "l": "(3Z)-decenoyl-[ACP] => (2E)-decenoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63017", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenamide + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18905", "l": "H2O + phosphonoacetaldehyde = acetaldehyde + H(+) + phosphate"}, {"i": "EC:3.11.1.1", "l": "\"Phosphonoacetaldehyde hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33423", "l": "N(pros)-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out) = diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein]"}, {"i": "EC:2.7.1.196", "l": "\"Protein-N(pi)-phosphohistidine--N,N'-diacetylchitobiose phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66721", "l": "ATP + H2O + N-[(S)-lactoyl]-L-phenylalanine(in) => ADP + H(+) + N-[(S)-lactoyl]-L-phenylalanine(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018643", "l": "carbon disulfide oxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189488", "l": "UROS transforms HMB to URO3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912374", "l": "Transport of NOTCH precursor to Golgi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47754", "l": "5-hydroxy-3-methyl-O-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine => 5-hydroxy-3-methyl-L-tyrosine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798372", "l": "ATM phosphorylates DYRK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14698", "l": "(2E,6E)-farnesol + NADP(+) => (2E,6E)-farnesal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12863", "l": "NH4(+) + xanthosine => guanosine + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061697", "l": "protein-glutaryllysine deglutarylase activity"}, {"i": "RHEA:47664", "l": "H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) = 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11166", "l": "1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13382", "l": "acetate + an acyl-CoA => a carboxylate + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.-.-", "l": "\"Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O(2)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19605", "l": "a chlorophyll + H2O = a chlorophyllide + H(+) + phytol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28562", "l": "D-alanine + pyridoxal 5'-phosphate = pyridoxamine 5'-phosphate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51857", "l": "(E)-hexadec-2-enoate(out) + ATP(in) + CoA(in) + H(+)(out) => (2E)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686469", "l": "Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75862", "l": "Fall Back to Closed Pre-initiation Complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32033", "l": "diphosphate + gamma-curcumene => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080079", "l": "cellobiose glucosidase activity"}, {"i": "MetaCyc:RXN-10773"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64456", "l": "L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.372", "l": "\"[Histone H4]-lysine(20) N-trimethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624800", "l": "CDK1 phosphorylates LBR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54198", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60323", "l": "N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607722", "l": "Active NIK phosphorylates IKKA dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937097", "l": "MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444476", "l": "FPRL2 receptor binds a wide range of ligands (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24842", "l": "4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36459", "l": "glycyl-L-proline + H2O = glycine + L-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371527", "l": "HSF1 trimer translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36671", "l": "(17Z)-hexacosenoyl-CoA + sphinganine = CoA + H(+) + N-[(17Z)-hexacosenoyl]dihydrosphingosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12071", "l": "apo-[ACP] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798743", "l": "Exocytosis of secretory granule membrane proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35903", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64689", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357479", "l": "p-AXL binds PI3K (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354173", "l": "Activation of Rap1 by cytosolic GEFs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5689317", "l": "Formation of the pre-incision complex in GG-NER (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "42.687140872802409", "identifiers": [{"i": "GO:0016740", "l": "transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193703", "l": "IKKbeta is activated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56378", "l": "3,5-dibromobenzene-1,2-diol + CO2 + 2 H2O + NADP(+) => 3-bromo-4,5-dihydroxybenzoate + bromide + 3 H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31270", "l": "6-hydroxyhexanoate + NADP(+) <=> 6-oxohexanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62199", "l": "2 [Fe(III)cytochrome c] + propan-2-ol <=> 2 [Fe(II)cytochrome c] + acetone + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798138", "l": "TP53 binds the CASP10 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2660816", "l": "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981892", "l": "Active G alpha (z) binds RGS proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43872", "l": "3-oxochol-4-en-22-oate + ATP + CoA = 3-oxochol-4-en-22-oyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961895", "l": "CCNA1 gene expression is stimulated by E2F1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22193", "l": "(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide => (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015160", "l": "beta-glucan transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42426", "l": "(2R,3S)-3-methylmalate => 2-methylmaleate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189069", "l": "sucrose + H2O => glucose + fructose (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042813", "l": "Wnt-activated receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31524", "l": "2-oxoglutarate + 2 H(+) + O2 => 3 CO2 + ethene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3785711", "l": "Telomere shortening during replicative exhaustion (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27690", "l": "ATP + dGDP = ADP + dGTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627056", "l": "Procaspase 9 forms dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382058", "l": "Nck binds to the active PDGF receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47608", "l": "3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59655", "l": "D-xylotetraono-1,5-lactone + H2O <=> D-xylotetraonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9649735", "l": "Intrinsic nucleotide exchange on RAS (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005168", "l": "neurotrophin TRKA receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3781941", "l": "WNTs are secreted in exosomes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31643", "l": "mycinamicin VI + S-adenosyl-L-methionine = H(+) + mycinamicin III + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.238", "l": "\"Mycinamicin VI 2''-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15090", "l": "(R)-lactate + A => AH2 + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64281", "l": "(S)-1-phenylethylamine + pyruvate => acetophenone + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59812", "l": "hexadecanoyl-CoA + N-terminal glycyl-[protein] = CoA + H(+) + N-terminal N(6)-hexadecanoylglycyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34247", "l": "1-deoxymethyl-sphinganine + NADP(+) = 1-deoxymethyl-3-dehydrosphinganine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56518", "l": "2 CO2 + 4 H2O + heme b => Fe-coproporphyrin III + 2 H(+) + 2 H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052622", "l": "ATP dimethylallyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49215", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,25-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23452", "l": "2'-deoxyadenosine + ATP = ADP + dAMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33291", "l": "L-pentahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-8-(methylsulfanyl)octanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266328", "l": "CETP-mediated lipid exchange: spherical HDL gains triacylglycerol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28146", "l": "geranylhydroquinone + O2 + reduced [NADPH--hemoprotein reductase] = 3''-hydroxygeranylhydroquinone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.174", "l": "\"Geranylhydroquinone 3''-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38784", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63025", "l": "(13Z)-docosenamide + H2O => (13Z)-docosenoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419644", "l": "Transphosphorylation of pLIMK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47356", "l": "an octanoate ester + H2O = an aliphatic alcohol + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23753", "l": "all-trans-undecaprenol + ATP => ADP + all-trans-undecaprenyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672083", "l": "KTN1 binds Kinesin-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045157", "l": "electron transporter, transferring electrons within the noncyclic electron transport pathway of photosynthesis activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53946", "l": "(2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + H(+) + NADPH => 2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83793", "l": "Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50780", "l": "NADP(+) + octanal = (2E)-octenal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36621", "l": "CoA + H(+) + N-(2-hydroxydocosanoyl)-sphinganine => 2-hydroxydocosanoyl-CoA + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46254", "l": "2 [Fe(III)-cytochrome b5] + a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 H2O => 2 [Fe(II)-cytochrome b5] + a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32274", "l": "(2R,3S)-3-isopropylmalate + NAD(+) <=> 4-methyl-2-oxopentanoate + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453342", "l": "PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034804", "l": "benzo(a)pyrene 11,12-epoxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879459", "l": "F-actin capping protein is a heterodimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3781941", "l": "WNTs are secreted in exosomes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018530", "l": "(R)-6-hydroxynicotine oxidase activity"}, {"i": "MetaCyc:R-6-HYDROXYNICOTINE-OXIDASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3814820", "l": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37620", "l": "(9Z)-octadecenoyl-CoA + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212614", "l": "Glutamine transport from astrocytes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54473", "l": "1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080069", "l": "7-methylthioheptyl-desulfoglucosinolate sulfotransferase activity"}, {"i": "MetaCyc:RXNQT-4332"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196753", "l": "2xPPCS ligates PPanK with Cys (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.4", "l": "\"N-acetylgalactosamine-6-sulfatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14412", "l": "cysteamine + O2 <=> H(+) + hypotaurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876868", "l": "ECE1 cleaves EDN1(53-90) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60579", "l": "[methyl-Co(III) tetramethylammonium-specific corrinoid protein] + coenzyme M <=> [Co(I) tetramethylammonium-specific corrinoid protein] + H(+) + methyl-coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173705", "l": "C5b binds C6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12941", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}, {"i": "EC:2.4.1.143", "l": "\"Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015086", "l": "cadmium ion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "62.948608359165036", "identifiers": [{"i": "GO:0016903", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810724", "l": "PI3 binds the bacterial surface (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63926", "l": "ADP + H(+) + N(4)-acetylcytidine 5'-phosphate => ATP + N(4)-acetylcytidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933523", "l": "Dimerzation of procaspase-8, procaspase-10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1369028", "l": "ABCAs mediate lipid efflux (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.373", "l": "\"Alpha-(1->2) branching sucrase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672011", "l": "p-AMPK:AMP binds the ULK complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19838", "l": "D-sorbitol 6-phosphate + NAD(+) => beta-D-fructose 6-phosphate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22574", "l": "AH2 + formaldehyde + L-glutamate => A + H2O + N-methyl-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61353", "l": "ATP + H2O + riboflavin(in) => ADP + H(+) + phosphate + riboflavin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3965450", "l": "DAAM1 recruits PFN1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-912627", "l": "CBL ubiquitinates PI3K (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0016615", "l": "malate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66419", "l": "ATP + glutathione(in) + glycoursodeoxycholate(in) + H2O <=> ADP + glutathione(out) + glycoursodeoxycholate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114671", "l": "vWF binds to collagen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41965", "l": "butanoyl-CoA + O2 => (2E)-butenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018606", "l": "benzenesulfonate dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18349", "l": "ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)"}, {"i": "EC:6.1.1.23", "l": "\"Aspartate--tRNA(Asn) ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53657", "l": "(5S,6R)-dihydroxy-(7E,9E,11Z,14Z)-eicosatetraenoate + O2 => (5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451310", "l": "Activation of Edited Kainate receptors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53949", "l": "ATP + holo-[BtrI ACP] + L-glutamate => ADP + gamma-L-glutamyl-[BtrI ACP] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004877", "l": "complement component C3b receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-398184", "l": "LARG activation by G alpha 12/13 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17852", "l": "(3R)-3-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201457", "l": "BMP2 binds to the receptor complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5227009", "l": "ABCF1 binds EIF2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5685230", "l": "CHEK1 phosphorylates RAD51 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618834", "l": "Activated calmodulin dissociates from CaMKII-gamma (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42991", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> cembrene C + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72691", "l": "Formation of the 43S pre-initiation complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56444", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110219", "l": "Cleavage of thymine by TDG glycosylase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1306876", "l": "NLRP3 activation by small molecules (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804193", "l": "TP53 stimulates PRDM1 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53466", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate => 1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol"}]}
{"type": "biolink:MolecularActivity", "ic": "76.711710297129045", "identifiers": [{"i": "GO:0046912", "l": "acyltransferase, acyl groups converted into alkyl on transfer"}, {"i": "EC:2.3.3.-", "l": "\"Acyl groups converted into alkyl groups on transfer\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29306", "l": "2 H(+)(in) + succinate(in) <=> 2 H(+)(out) + succinate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102631", "l": "caffeoylglucose 3-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-15537"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22642", "l": "3-oxosphinganine + H(+) + NADPH => NADP(+) + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34700", "l": "(2E,6E)-farnesyl diphosphate => (-)-alpha-isocomene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10699", "l": "a long-chain fatty acid + ATP + holo-[mycocerosate synthase] <=> AMP + diphosphate + long-chain fatty acyl-[mycocerosate synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31507", "l": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate"}, {"i": "EC:4.3.3.6", "l": "\"Pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66278", "l": "H(+) + tigogenin 3-O-beta-D-glucopyranoside + UDP => tigogenin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203070", "l": "Association of profilin with monomeric actin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32885", "l": "(+)-artemisinic aldehyde + H(+) + NADPH => (11R)-dihydroartemisinic aldehyde + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1170539", "l": "Prolactin receptor is internalized (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19665", "l": "6-carboxyhexanoyl-CoA + NAD(+) = 6-carboxyhex-2-enoyl-CoA + H(+) + NADH"}, {"i": "EC:1.3.1.62", "l": "\"Pimeloyl-CoA dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187382", "l": "Degradation of ubiquitinated SMAD3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102303", "l": "resveratrol 3,5-O-dimethyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14907", "l": "5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine => 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214393", "l": "Phosphorylated REL is cleaved by and dissociates from DREDD in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371435", "l": "Constitutive phosphorylation by GSK3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028583", "l": "Phosphorylation of YAP by LATS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33820", "l": "3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate => 3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420083", "l": "PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54425", "l": "L-aspartyl-[protein] + NAD(+) => 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787737", "l": "CSF3R binds CSF3 dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17762", "l": "an aromatic primary alcohol + NADP(+) => an aromatic aldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23701", "l": "5,10-methenyltetrahydrofolate + H2O => (6S)-10-formyltetrahydrofolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49216", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O = 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + phosphate"}, {"i": "EC:3.1.3.103", "l": "\"3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35272", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046565", "l": "3-dehydroshikimate dehydratase activity"}, {"i": "RHEA:24848", "l": "3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O"}, {"i": "EC:4.2.1.118", "l": "\"3-dehydroshikimate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373732", "l": "Nephrin trans-homophilic interaction (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "73.153983691316824", "identifiers": [{"i": "GO:0005244", "l": "voltage-gated ion channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42054", "l": "9-cis-retinal + H(+) + NADH => 9-cis-retinol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42713", "l": "S-adenosyl-L-methionine + uridine(54) in tRNA => 5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47920", "l": "ganglioside GM2 (d18:1(4E)/18:0) + H2O = ganglioside GA2 (d18:1(4E)/18:0) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20459", "l": "D-arabinono-1,4-lactone + H(+) + NADH => D-arabinose + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27515", "l": "H2O + sphinganine 1-phosphate => phosphate + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37733", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14197", "l": "ATP + L-aspartate + NH4(+) = ADP + H(+) + L-asparagine + phosphate"}, {"i": "EC:6.3.1.4", "l": "\"Aspartate--ammonia ligase (ADP-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50639", "l": "a 3-(omega-methylsulfanyl)alkylmalate <=> a 2-(omega-methylsulfanyl)alkylmaleate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-182986", "l": "CBL-mediated ubiquitination of CIN85 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33375", "l": "a 1-acylglycerone 3-phosphate + H(+) + NADPH = a 1-acyl-sn-glycero-3-phosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102446", "l": "rhamnetin 3-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-13932"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416683", "l": "SEMA3E binds to PLXND1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13602", "l": "4-hydroxy-L-proline + NAD(+) => 4-oxo-L-proline + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11379", "l": "(19S)-geissoschizine + NADP(+) <=> 4,21-dehydrogeissoschizine + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428918", "l": "Dissociation of the TP:G13 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72663", "l": "De novo formation of eIF2:GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20031", "l": "H(+) + NADPH + vellosimine => 10-deoxysarpagine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54440", "l": "a (4S)-2,3-dehydroflavan-3,4-diol + H(+) = a 4-H-anthocyanidin with a 3-hydroxy group + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36811", "l": "acetyl-CoA + GDP-alpha-D-perosamine = CoA + GDP-N-acetyl-alpha-D-perosamine + H(+)"}, {"i": "EC:2.3.1.227", "l": "\"GDP-perosamine N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448958", "l": "Nuclear translocation of p38 MAPK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37095", "l": "(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(12Z,15Z,18Z,21Z)-tetracosatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60886", "l": "(N(7)-methyl 5'-triphospho-guanosine)-adenosine + a 5'-end phospho-ribonucleoside in mRNA + H(+) => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine-phospho-ribonucleoside in mRNA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47901", "l": "ganglioside GM3 (d18:1(4E)) + H2O => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389756", "l": "AKT interacts and phosphorylates Cot (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27451", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate => a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009033", "l": "trimethylamine-N-oxide reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31596", "l": "(Z)-2-methylureidoacrylate + H2O => (Z)-2-methylaminoacrylate + carbamate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102248", "l": "diacylglycerol transacylase activity"}, {"i": "MetaCyc:RXN-12383"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44813", "l": "1,4-dihydroxy-2-naphthoate + all-trans-undecaprenyl diphosphate + H(+) => 2-demethylmenaquinol-11 + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37399", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350598", "l": "Arginine<=>Agmatine+CO2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47032", "l": "AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]"}, {"i": "EC:2.8.1.13", "l": "\"tRNA-uridine 2-sulfurtransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22264", "l": "3,5,6-trichloropyridin-2-ol + FADH2 + O2 = 3,6-dichloropyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47395", "l": "H2O + hexadecanoate ester <=> an aliphatic alcohol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19922", "l": "D-ribitol 5-phosphate + NADP(+) => D-ribulose 5-phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62314", "l": "H(+) + salicylate 2-O-beta-D-glucoside + UDP => salicylate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672980", "l": "Dissociation of RAS:RAF complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-398184", "l": "LARG activation by G alpha 12/13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29336", "l": "H2O + L-alanyl-L-glutamate => L-alanine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66150", "l": "CoA + H(+) + N-(2-phenylethyl)acetamide => 2-phenylethylamine + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23578", "l": "berbamunine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (R)-N-methylcoclaurine + (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10481", "l": "2-oxoglutarate + 4-hydroxy-L-glutamate => 4-hydroxy-2-oxoglutarate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19622", "l": "a nucleoside 2',3'-cyclic phosphate + H2O => a nucleoside 3'-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2984258", "l": "NEK9 phosphorylates NEK6/NEK7 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.99.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432054", "l": "Aquaporin-1 passively transports water out of cell (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030409", "l": "glutamate formimidoyltransferase activity"}, {"i": "MetaCyc:GLUTAMATE-FORMIMINOTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58540", "l": "2 L-ascorbate + N-dodecanoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-dodecanoyl-(2S)-hydroxyglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48332", "l": "a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35044", "l": "N-(4-aminobenzoyl)-L-glutamate(in) => N-(4-aminobenzoyl)-L-glutamate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2129362", "l": "Fibrillin microfibril assembly (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47426", "l": "(3S)-hydroxy-(9Z-octadecenoyl)-CoA => (2E,9Z)-octadecadienoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34343", "l": "(20R,22R)-20,22-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 4-methylpentanal + 2 H2O + 2 oxidized [adrenodoxin] + pregnenolone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.51", "l": "\"Ophiolysin\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047971", "l": "guanidinobutyrase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21896", "l": "(R)-1-aminopropan-2-yl phosphate + adenosylcob(III)yrate + ATP = adenosylcob(III)inamide phosphate + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10691", "l": "H2O + streptomycin 6-phosphate <=> phosphate + streptomycin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.8"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0030284", "l": "estrogen receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28914", "l": "H(+)(out) + L-lysine(out) <=> H(+)(in) + L-lysine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.n2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15588", "l": "15-cis-phytoene + 4 A <=> 4 AH2 + all-trans-lycopene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34963", "l": "Na(+)(in) = Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25786", "l": "(S)-lactaldehyde + pyruvate => 2-dehydro-3-deoxy-L-rhamnonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13128", "l": "CoA + glutathione disulfide <=> CoA-glutathione + glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61234", "l": "(S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+) => H2O + L-isoleucine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852200", "l": "Inactivation of LCK by PTPN22 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202724", "l": "P-selectin binds P-selectin ligand (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47599", "l": "an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate <=> an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy- beta-D-glucuronosyl)-N-acetyl- alpha-D-glucosaminyl phosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418553", "l": "cAMP degradation by Phosphodiesterases (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004379", "l": "glycylpeptide N-tetradecanoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54924", "l": "(7Z)-tetradecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(9Z)-hexadecenoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0010852", "l": "cyclase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56806", "l": "2 cob(I)yrinate a,c diamide--[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein] => 2 cob(II)yrinate a,c diamide--[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39524", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA => (2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9709406", "l": "CO binds to Cytochrome c oxidase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55530", "l": "(4-hydroxyphenyl)acetaldehyde + CO2 + H2O2 + NH4(+) => H(+) + H2O + L-tyrosine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48617", "l": "H2O + leukotriene D4 => glycine + leukotriene E4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54518", "l": "(13R)-manoyl oxide + diphosphate => 8-hydroxycopalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.n2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25062", "l": "3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) = 3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH"}, {"i": "RHEA:25066", "l": "(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH"}, {"i": "EC:1.3.1.87", "l": "\"3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983138", "l": "Transport of MHC heterotrimer to ER exit site (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43752", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein uS5] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein uS5]"}, {"i": "EC:2.3.1.267", "l": "\"[Ribosomal protein S5]-alanine N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004016", "l": "adenylate cyclase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29421", "l": "H(+)(in) + Na(+)(out) => H(+)(out) + Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38578", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39554", "l": "(2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH <=> (21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0045159", "l": "myosin II binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14471", "l": "(2Z,4E)-2-aminomuconate + 2 H(+) + NADH => 2-aminomuconate 6-semialdehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429497", "l": "SLP-76 stimulates PLC gamma 2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30598", "l": "4-hydroxyphenylacetate + FADH2 + O2 <=> 3,4-dihydroxyphenylacetate + FAD + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866277", "l": "AP-2 directly binds some endocytic cargo (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854222", "l": "TBC1D3 associates with RAB5 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12835", "l": "a carboxylate + D-glutamate => an N-acyl-D-glutamate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693243", "l": "RHOD translocates to the Golgi membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54413", "l": "a 3-oxo-5beta-steroid + NADP(+) => a 3-oxo-Delta(4)-steroid + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34242", "l": "L-glutamate <=> 3-aminopentanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37557", "l": "kanosamine + phosphate => D-kanosamine 6-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4411373", "l": "NLK translocates to nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668545", "l": "NIK autophosphorylates on T559 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33465", "l": "ergosta-5,7,24(28)-trien-3beta-ol + 2 H2O + NADP(+) => episterol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12321", "l": "17-O-acetylnorajmaline + NADP(+) => 1,2-dihydrovomilenine + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41365", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31119", "l": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA = (2E)-2-methylbut-2-enoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102323", "l": "2-isopropylphenol monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48639", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62624", "l": "[glutaredoxin]-dithiol + a hydroperoxide = [glutaredoxin]-disulfide + an alcohol + H2O"}, {"i": "EC:1.11.1.25", "l": "\"Glutaredoxin-dependent peroxiredoxin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28081", "l": "2-hydroxyethylphosphonate + NAD(+) <=> H(+) + NADH + phosphonoacetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42234", "l": "1-(9Z)-octadecenoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983426", "l": "Capturing cargo and formation of prebudding complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57768", "l": "2-nitrotoluene + NADH + O2 = 3-methylcatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444476", "l": "FPRL2 receptor binds a wide range of ligands (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799350", "l": "Exocytosis of specific granule membrane proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656781", "l": "Deltarasin binds PDE6D (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033998", "l": "inulin fructotransferase (DFA-III-forming) activity"}, {"i": "MetaCyc:4.2.2.18-RXN"}, {"i": "EC:4.2.2.18", "l": "\"Inulin fructotransferase (DFA-III-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25871", "l": "H2O + N(1),N(12)-diacetylspermine + O2 <=> 3-acetamidopropanal + H2O2 + N(1)-acetylspermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0034071", "l": "aminoglycoside phosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23546", "l": "a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP => a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40065", "l": "2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA => 6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0016885", "l": "ligase activity, forming carbon-carbon bonds"}, {"i": "EC:6.4.-.-", "l": "\"Forming carbon-carbon bonds\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102327", "l": "3-oxoacyl-CoA hydrolase activity"}, {"i": "MetaCyc:RXN-13247"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033459", "l": "GAA codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018819", "l": "lactoyl-CoA dehydratase activity"}, {"i": "MetaCyc:RXN-781"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197963", "l": "DHFR2 reduces FOLA to DHF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24452", "l": "L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.80", "l": "\"Protein-glutamate O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14360", "l": "ATP + riboflavin <=> ADP + FMN + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18044", "l": "2 H2O + NH4(+) + 6 oxidized [2Fe-2S]-[ferredoxin] <=> 8 H(+) + nitrite + 6 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021523", "l": "WWP2 ubiquitinates NOTCH3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54800", "l": "[nsP1 protein]-N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidine + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) = [nsP1 protein]-L-histidine + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008558", "l": "ABC-type guanine transporter activity"}, {"i": "MetaCyc:3.6.3.37-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22112", "l": "isoxazolin-5-one + O-acetyl-L-serine = 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+)"}, {"i": "EC:2.5.1.118", "l": "\"Beta-(isoxazolin-5-on-2-yl)-L-alanine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-179410", "l": "Association of Nek2A with MCC:APC/C (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392834", "l": "Activation of EPACs by cAMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654625", "l": "Activated FGFR3 binds SHC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49847", "l": "(-)-dehydrodiconiferyl acid + a quinone <=> (-)-dehydrodiconiferyl acid ketone + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60154", "l": "L-glutamate + L-glutamyl-[protein] => H2O + L-gamma-glutamyl-L-glutamyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417842", "l": "P2Y10 receptor can bind to LPA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112395", "l": "Abortive termination of elongation after arrest (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52254", "l": "2 5'-deoxyadenosine + a bacteriochlorophyllide e + 2 H(+) + 2 L-methionine => a bacteriochlorophyllide c + H2O + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56286", "l": "a (3R)-2'-hydroxyisoflavanone + H(+) + NADPH => a (3R,4R)-4,2'-dihydroxyisoflavan + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65536", "l": "1,3,7-trimethylurate + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + theacrine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39580", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA => (2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34744", "l": "15-methylhexadecasphinganine 1-phosphate => 13-methyltetradecanal + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654571", "l": "Activated FGFR1 binds FRS3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66546", "l": "H(+) + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein] => L-cysteinyl-[protein] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51182", "l": "5-methylcytidine(49) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(49) in tRNA(Asp) + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15807", "l": "(4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate => (7R,8S)-7,8-diammoniononanoate + ATP + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35674", "l": "(S)-5'-oxoaverantin + H(+) <=> (1'S,5'S)-averufin + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0008516", "l": "hexose uniporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20870", "l": "2 D-glucose => alpha,alpha-trehalose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60604", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine = 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2889070", "l": "SLC9B2 exchanges Na+, Li+ for H+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199144", "l": "Nectin 2 binds CD226 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50226", "l": "2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-hexaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607753", "l": "CARD9 oligomerizes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372819", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000310", "l": "AURKA phosphorylates PLK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801109", "l": "CHM binds RGGT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949276", "l": "RUNX3:CBFB binds the RORC gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37991", "l": "delta-tocopherol + S-adenosyl-L-methionine = beta-tocopherol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191402", "l": "Reduction of presqualene diphosphate to form squalene (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951595", "l": "CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380782", "l": "STAT binds to the active receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47374", "l": "a quinol + D-glucono-1,5-lactone => a quinone + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52955", "l": "lithocholate + UDP-alpha-D-glucuronate <=> lithocholoyl-24-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15529", "l": "bis(2-ethylhexyl)phthalate + H2O = 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+)"}, {"i": "EC:3.1.1.60", "l": "\"Bis(2-ethylhexyl)phthalate esterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43966", "l": "1-octadecanoyl-2-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031492", "l": "nucleosomal DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11605", "l": "[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA => [(2->8)-O(7),N-diacetyl-alpha-D-neuraminosyl](n) + n CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669023", "l": "TWEAK binds FN14 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "79.682896251205548", "identifiers": [{"i": "GO:0005548", "l": "phospholipid transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73800", "l": "SAICAR => AICAR + Fumarate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43473", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693148", "l": "BCKDK phosphorylates BCKDH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102287", "l": "4-coumaroylhexanoylmethane synthase activity"}, {"i": "MetaCyc:RXN-12668"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196417", "l": "Reduction of desmosterol to cholesterol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22654", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate => 2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52329", "l": "L-arginine + O2 + reduced [flavodoxin] => H(+) + H2O + N(omega)-hydroxy-L-arginine + oxidized [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071161", "l": "cyanophycin synthetase activity (L-arginine-adding)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53823", "l": "chenodeoxycholate + NADP(+) <=> 7-oxolithocholate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.32"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4093331", "l": "Ras:GTP binds p120-RasGAP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604731", "l": "Autocatalytic activation of MMP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786421", "l": "CHIA hydrolyses chitin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31284", "l": "FAD + H(+) + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30688", "l": "(4R)-4-hydroxy-2-oxoglutarate => glyoxylate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50718", "l": "FMN + formaldehyde + 2 H(+) + H2O + methanesulfinate => dimethyl sulfone + FMNH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932351", "l": "KEAP1 facilitates ubiquitination of NFE2L2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex. (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168644", "l": "CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28650", "l": "acetophenone + 2 ATP + H2O + hydrogencarbonate <=> 3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60050", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 4 H2O + 3 NAD(+) => a 3beta-hydroxy-4,4-dimethylsteroid + 2 H(+) + 3 NADH + 3 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17959", "l": "H2O + propynoate => 3-oxopropanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14587", "l": "CO2 + gibberellin A9 + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => gibberellin A12 + 5 H(+) + 3 O2 + 4 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20900", "l": "H(+) + H2O + N-benzyloxycarbonylglycine = benzyl alcohol + CO2 + glycine"}, {"i": "EC:3.5.1.58", "l": "\"N-benzyloxycarbonylglycine hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46891", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + O2 <=> 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63010", "l": "(6Z)-octadecenoate + NH4(+) => (6Z)-octadecenamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814387", "l": "CASP14 cleaves filaggrin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982810", "l": "JAK2 phosphorylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39423", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA = (2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23596", "l": "H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate"}, {"i": "EC:1.1.1.22", "l": "\"UDP-glucose 6-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033760", "l": "2'-deoxymugineic-acid 2'-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9007882", "l": "IL1F10 is cleaved (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31727", "l": "FADH2 + O2 + styrene = (2S)-2-phenyloxirane + FAD + H(+) + H2O"}, {"i": "EC:1.14.14.11", "l": "\"Styrene monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33648", "l": "(9Z)-hexadecenoate + ATP + CoA => (9Z)-hexadecenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60676", "l": "(S)-(-)-citronellol + NAD(+) = (S)-(-)-citronellal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0070576", "l": "vitamin D 24-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375133", "l": "Basigin binds Mannose-carrying cell recognition molecules (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9006870", "l": "IL21 receptor STAT phosphorylation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001096", "l": "TFIIF-class transcription factor complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210959", "l": "Endocytosis of cya:lef:(pagA(197-794):ANTXR2 oligomer) (plasma membrane to endosome membrane) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11049", "l": "1-organyl-2-lyso-sn-glycero-3-phospholipid + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine => 1-O-alkyl-sn-glycero-3-phosphocholine + 1-organyl-2-acetyl-sn-glycero-3-phospholipid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49490", "l": "2-oxoglutarate + GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+) => GDP-4-dehydro-alpha-D-rhamnose + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34876", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA + 2 H2O + NADP(+) => 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9690494", "l": "RHOB translocates to the endosome membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111956", "l": "Calmodulin activates Cam-PDE 1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010997", "l": "anaphase-promoting complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63367", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + O2 <=> (S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-1,3-oxazole-[protein] + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61962", "l": "2 [Fe(III)-cytochrome b5] + a 1-O-(1Z-hexadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H2O => 2 [Fe(II)-cytochrome b5] + a 1-O-hexadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83650", "l": "FasL:Fas binds FADD (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52880", "l": "16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391168", "l": "SIRP gamma binds CD47 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57828", "l": "dIMP + H2O = 2-deoxy-D-ribose 5-phosphate + hypoxanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21215", "l": "H2O + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] <=> 4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033921", "l": "capsular-polysaccharide endo-1,3-alpha-galactosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52294", "l": "13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379387", "l": "COMT transfers Met to DA to form 3MT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20317", "l": "L-proline + NADP(+) = 1-pyrroline-2-carboxylate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797712", "l": "CDK12 stimulates expression of DNA repair genes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61738", "l": "rubusoside + UDP => steviolmonoside + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15266", "l": "1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate => H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668467", "l": "2xTNFR2 binds TNFA trimer:TNFR2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156910", "l": "Formation of eEF1B complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390649", "l": "CHRM1,3,5 bind acetylcholine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32659", "l": "(6E)-8-hydroxygeraniol + 2 NADP(+) = (6E)-8-oxogeranial + 2 H(+) + 2 NADPH"}, {"i": "EC:1.1.1.324", "l": "\"8-hydroxygeraniol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682863", "l": "RNF168 binds DNA DSBs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983696", "l": "The Immunoglobulin of the BCR binds antigen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16527", "l": "2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+) => 2-dehydro-3-deoxy-D-galactonate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10905", "l": "[cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A => AH2 + C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41219", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28459", "l": "biotin(in) => biotin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004119", "l": "cGMP-inhibited cyclic-nucleotide phosphodiesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65442", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidyl-adenosine in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidyl-adenosine in mRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198983", "l": "NKG2D homodimer interacting with ligands (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38215", "l": "D-glucose 6-phosphate + NAD(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14009", "l": "2 dimethylallyl diphosphate = (R,R)-chrysanthemyl diphosphate + diphosphate"}, {"i": "EC:2.5.1.67", "l": "\"Chrysanthemyl diphosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038085", "l": "vascular endothelial growth factor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050159", "l": "orsellinate decarboxylase activity"}, {"i": "RHEA:16733", "l": "H(+) + orsellinate = CO2 + orcinol"}, {"i": "EC:4.1.1.58", "l": "\"Orsellinate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392751", "l": "L1 linked to actin cytoskeleton by ankyrin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649726", "l": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14920", "l": "3 O2 + obtusifoliol + 3 reduced [NADPH--hemoprotein reductase] <=> 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46889", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + O2 => 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168317", "l": "Recruitment of Karyopherin Beta to form a Trimeric Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53753", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-beta-D-galactopyranosyl]-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-933533", "l": "Dimerization of p-IRF7 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32388", "l": "dihydrocarveol + NAD(+) => dihydrocarvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8963915", "l": "1,25(OH)2D binds VDR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.37"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209815", "l": "Tyrosine is monoiodinated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102760", "l": "6-deoxocathasterone hydroxylase activity"}, {"i": "MetaCyc:RXN-774"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111915", "l": "CAMK4 autophosphorylates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977371", "l": "Factor I inactivates Factor H-boundC3b (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705323", "l": "Phosphorylation of TBK1/IKBKE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30143", "l": "H2O + octanoyl-CoA = CoA + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0015450", "l": "protein-transporting ATPase activity"}, {"i": "REACT:R-HSA-1222523", "l": "SodB gets secreted (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050357", "l": "tropinesterase activity"}, {"i": "MetaCyc:TROPINESTERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784959", "l": "BPHL hydrolyses VACV to ACV (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34205", "l": "aureusidin 6-O-beta-glucoside + H2O => 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66337", "l": "L-glutamate(out) => L-glutamate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607746", "l": "PKC-delta is activated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.12"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19748", "l": "3,3',5-triiodo-L-thyronine + A + H(+) + iodide <=> AH2 + L-thyroxine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420980", "l": "Activation of Ca permeable AMPA receptors (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191790", "l": "Loading and methylation of Sm proteins onto SMN Complexes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11296", "l": "2,5-dioxopentanoate + H2O + NADP(+) = 2-oxoglutarate + 2 H(+) + NADPH"}, {"i": "EC:1.2.1.26", "l": "\"2,5-dioxovalerate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3321883", "l": "MSL acetylates histone H4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30315", "l": "1,7-dimethylxanthine + H(+) + NADH + O2 = 7-methylxanthine + formaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30872", "l": "2-deoxy-D-ribose + ATP => 2-deoxy-D-ribose 5-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40322", "l": "O2 + tetracosanoyl-CoA <=> (2E)-tetracosenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59103", "l": "diglucosyl-enterobactin + UDP-alpha-D-glucose <=> H(+) + triglucosyl-enterobactin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65813", "l": "2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + AH2 + O2 => A + H2O + N(6)-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-2-(methylsulfanyl)adenosine(37) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052737", "l": "pyruvate dehydrogenase (quinone) activity"}, {"i": "KEGG.REACTION:R03145"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28640", "l": "(2Z,6E)-farnesyl diphosphate => (-)-gamma-cadinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10006", "l": "benzyl thiocyanate => benzyl isothiocyanate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5658438", "l": "SPRED dimer binds NF1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45324", "l": "H2O + N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine = H(+) + N-tetracosanoyl-sphing-4-enine + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53177", "l": "H2O + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222399", "l": "Iron is reduced and separates from mycobactin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30685", "l": "H(+) + N-acetyl-D-mannosamine + UDP => H2O + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40222", "l": "H2O + malonyl-CoA <=> CoA + H(+) + malonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60236", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate"}, {"i": "EC:1.14.11.69", "l": "\"[Histone H3]-trimethyl-L-lysine(36) demethylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23187", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate <=> (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448963", "l": "Interaction of MyoD:E protein with MEF2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35508", "l": "30-hydroxy-11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => glycyrrhetaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000310", "l": "AURKA phosphorylates PLK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809254", "l": "MTMR8 binds MTMR9 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874079", "l": "PTK2 binds activated MET (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168885", "l": "Haptoglobin binds Hemoglobin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878654", "l": "ACP6 hydrolyses MYS-LPA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389862", "l": "Conversion of glyoxylate to oxalate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32969", "l": "a fatty acid + H(+) + sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19682", "l": "ATP + biotin + CoA => AMP + biotinyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43455", "l": "2 H(+) + hexanoyl-CoA + 2 malonyl-CoA <=> 4-hydroxy-6-pentylpyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24933", "l": "H(+) + hydrogen sulfide + NH4(+) + pyruvate => H2O + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53160", "l": "H2O + N-acyl-sn-glycero-3-phosphoethanolamine = an N-acylethanolamine + H(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60653", "l": "an N-(acyl)-sphingosylphosphocholine => an N-(acyl)-sphingosyl-1,3-cyclic phosphate + choline"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033966", "l": "N-substituted formamide deformylase activity"}, {"i": "RHEA:12096", "l": "H2O + N-benzylformamide = benzylamine + formate"}, {"i": "MetaCyc:3.5.1.91-RXN"}, {"i": "EC:3.5.1.91", "l": "\"N-substituted formamide deformylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21688", "l": "a polyvinyl alcohol + n O2 = an oxidized polyvinyl alcohol + n H2O2"}, {"i": "EC:1.1.3.30", "l": "\"Polyvinyl-alcohol oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420883", "l": "Opsins act as GEFs for G alpha-t (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57207", "l": "glyoxal + L-lysyl-[protein] <=> N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27989", "l": "hydroxyacetone + NADP(+) <=> H(+) + methylglyoxal + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49308", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O = a neolactoside nLc4Cer(d18:0) + L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855160", "l": "I(1,3,4,5,6)P5 transports from the ER lumen to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5140741", "l": "WNT5A binds FZD and ROR receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32518", "l": "(4S,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O <=> (3S,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19756", "l": "ATP + diphthine-[translation elongation factor 2] + NH4(+) <=> AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57568", "l": "7-deoxyloganetic alcohol + O2 + reduced [NADPH--hemoprotein reductase] = 7-deoxyloganetic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37146", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32762", "l": "L-lysine <=> (3R)-3-methyl-D-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49099", "l": "H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine <=> 3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51992", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] = an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.43", "l": "\"(Methylsulfanyl)alkanaldoxime N-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49231", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + bacteriochlorophyllide a + H(+) <=> diphosphate + geranylgeranyl-bacteriochlorophyllide a"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045508", "l": "interleukin-26 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2530429", "l": "Formation of soluble VTN:C5b-C9  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40911", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12546", "l": "2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate => 2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36203", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + ethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373867", "l": "BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201637", "l": "Caspase-mediated cleavage of plectin-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685607", "l": "Sialic acid binds SIGLEC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58990", "l": "(E)-4-hydroxynon-2-enoate + H(+) + H2O2 => (E)-4-hydroxynon-2-enal + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43213", "l": "adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11173", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine => (6S)-5,6,7,8-tetrahydrofolate + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33740", "l": "2 H(+) + hexadecanoate + NADH => H2O + hexadecanal + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31678", "l": "NADP(+) + raucaffrinoline <=> H(+) + NADPH + perakine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39202", "l": "(3R)-hydroxytetracosanoyl-CoA <=> (2E)-tetracosenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59861", "l": "3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->6)-N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033794", "l": "sarcosine reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2529020", "l": "CK2 phosphorylates condensin I subunits (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46418", "l": "(6Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51505", "l": "a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D-glucose => a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016907", "l": "G protein-coupled acetylcholine receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15077", "l": "H(+) + N-[(R)-pantothenoyl]-L-cysteine = (R)-pantetheine + CO2"}, {"i": "EC:4.1.1.30", "l": "\"Pantothenoylcysteine decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18079", "l": "H(+) + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide => L-arginyl-[dinitrogen reductase] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28821", "l": "5-dehydro-D-gluconate(out) + H(+)(out) => 5-dehydro-D-gluconate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5662466", "l": "XYLB phosphorylates D-xylulose (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61391", "l": "ATP + biotin(in) + H2O <=> ADP + biotin(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19549", "l": "H2O + orsellinate depside = H(+) + 2 orsellinate"}, {"i": "EC:3.1.1.40", "l": "\"Orsellinate-depside hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474210", "l": "Collagen type III degradation by MMP14 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38143", "l": "carbon disulfide + 2 H2O = CO2 + 2 H(+) + 2 hydrogen sulfide"}, {"i": "EC:3.13.1.5", "l": "\"Carbon disulfide hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084912", "l": "Arresten binds integrin alpha1beta1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41367", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29906", "l": "ATP + D-ribose(out) + H2O <=> ADP + D-ribose(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9652264", "l": "ERBB2 binds TKIs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41604", "l": "1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983152", "l": "Transfer of ubiquitin from E1 to E2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32594", "l": "(4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O <=> (3R,6S)-6-hydroxy-3,7-dimethyloctanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40956", "l": "(R)-5-phosphomevalonate + ATP => ADP + CO2 + isopentenyl phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47175", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NAD(+) <=> 5alpha-cholest-8-en-3-one + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614544", "l": "Sulfite is oxidized to sulfate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013109", "l": "RHOC GEFs activate RHOC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64827", "l": "1-naphthaleneacetamide + H2O <=> 1-naphthaleneacetate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51743", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A <=> a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429497", "l": "SLP-76 stimulates PLC gamma 2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37749", "l": "1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-octadecyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21327", "l": "2 H(+) + reduced [rubredoxin] + superoxide <=> H2O2 + oxidized [rubredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38551", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoate + O2 = (R)-2-hydroxyhexadecanoate + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34750", "l": "15-methylhexadecasphinganine + ATP <=> 15-methylhexadecasphinganine 1-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64581", "l": "(2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate => diphosphate + nerylneryl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33208", "l": "ATP + H(+) + L-glutamate + NADPH => ADP + L-glutamate 5-semialdehyde + NADP(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445700", "l": "Myosin Binds ATP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008889", "l": "glycerophosphodiester phosphodiesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74885", "l": "GUCYs converts GTP to cGMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34646", "l": "2 S-adenosyl-L-methionine + squalene <=> 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + 2 H(+) + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174959", "l": "The acetyl group from acetyl-CoA is transferred to the NAT1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47985", "l": "H2O + presqualene diphosphate => diphosphate + hydroxysqualene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22621", "l": "H(+) + L-tryptophan + O2 => 3-indoleglycolaldehyde + CO2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35646", "l": "a (2R)-2-hydroxycarboxylate + NAD(+) <=> a 2-oxocarboxylate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2509838", "l": "ITPA hydrolyses dITP to dIMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66367", "l": "(3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H2O <=> 6-methyl-3,7-dioxodecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803719", "l": "TP53 binds ZNF385A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39009", "l": "a cholesterol ester(out) => a cholesterol ester(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42306", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655846", "l": "Expression of Mevalonate Kinase (MVK) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029268", "l": "Phosphorylation and activation of PLCG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174209", "l": "Phosphorylated Emi1 binds the beta-TrCP in the SCF complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044605", "l": "phosphocholine transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51107", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445089", "l": "Dephosphorylation of pL1 (Y1176) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31109", "l": "(2-hydroxyphenyl)acetate + CO2 => 3-phenylpyruvate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34239", "l": "L-glutamate = 3-aminopentanedioate"}, {"i": "EC:5.4.3.9", "l": "\"Glutamate 2,3-aminomutase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047640", "l": "aldose 1-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014293", "l": "RAC2 GDIs block activation of RAC2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-481009", "l": "Exocytosis of platelet dense granule content (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22349", "l": "4-aminoimidazole + H(+) + H2O => imidazol-4-one + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34076", "l": "an acyl phosphate + sn-glycerol 3-phosphate => a 1-acyl-sn-glycero-3-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58829", "l": "(9S,10R)-epoxy-octadecanoate + H2O => 9R,10R-dihydroxyoctadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5681980", "l": "ATG12 binds ATG7 dimer (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28732", "l": "H(+)(out) + L-leucine(in) => H(+)(in) + L-leucine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17738", "l": "NADP(+) + shikimate => 3-dehydroshikimate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349626", "l": "Integrin alpha2beta1 binds laminin-332 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358790", "l": "RNF41 ubiquitinates ERBB3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849878", "l": "PSD-95 binds NMDA receptor (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29773", "l": "ADP + arsenate(out) + H(+) + phosphate => arsenate(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33930", "l": "4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2 <=> 2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28633", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28581", "l": "Co(2+)(in) <=> Co(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-525833", "l": "NCAM1 interacts with T- and L-type VDCC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52459", "l": "testosterone + UDP-alpha-D-glucuronate <=> H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109700", "l": "AKT2 binds PIP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015312", "l": "polyamine:proton antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62219", "l": "isoepoxydon + NADP(+) <=> H(+) + NADPH + phyllostine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483087", "l": "PI is exchanged with PC by PITPNB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432593", "l": "Cytosolic JET binds to CRY, facilitating its ubiquitination (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102500", "l": "beta-maltose 4-alpha-glucanotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853792", "l": "RET tyrosine phosphorylation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099621", "l": "undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785668", "l": "Defective LARGE does not transfer Xyl from UDP-Xyl to GlcA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33602", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + N-hexacosanoylsphinganine + O2 <=> 2 [Fe(III)-cytochrome b5] + H2O + N-hexacosanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38166", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA <=> 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030750", "l": "putrescine N-methyltransferase activity"}, {"i": "KEGG.REACTION:R01153"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42498", "l": "10-deacetyl-2-debenzoylbaccatin III => 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58454", "l": "H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63237", "l": "ATP + streptomycin => 6-O-adenylylstreptomycin + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62244", "l": "a cytidine(6-4)thymidine in DNA = a cytidine-thymine dinucleotide in DNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50366", "l": "(S)-nandinine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160874", "l": "HYAL1 hydrolyses (HA)50 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64994", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-acetyl-4'-phosphopantetheine => acetyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53129", "l": "delta-carotene => epsilon-carotene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14999", "l": "deoxylimononate D-ring-lactone + H(+) => deoxylimonoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008482", "l": "sulfite oxidase activity"}, {"i": "KEGG.REACTION:R00533"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55559", "l": "a hydroperoxyeicosatetraenoate <=> an oxoeicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005366", "l": "myo-inositol:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44567", "l": "4-hydroxybenzoate + all-trans-decaprenyl diphosphate <=> 4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445448", "l": "HHIP binds Hedgehog (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66060", "l": "2-oxohexanoate + L-kynurenine = H2O + kynurenate + L-2-aminohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68688", "l": "CDC6 association with ORC:origin complexes mediated by MCM8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23013", "l": "a fatty acid + S-adenosyl-L-methionine => a fatty acid methyl ester + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43256", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008986", "l": "pyruvate, water dikinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46232", "l": "(9Z,12Z)-hexadecadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (9Z,12Z,15Z)-hexadecatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008869", "l": "galactonate dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018804", "l": "RAC3 GEFs activate RAC3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3229181", "l": "CALM1:Ca2+ binds CNG channel (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41682", "l": "a 2-all-trans-polyprenylphenol + CO2 => a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163310", "l": "TFAM binds to mitochondrial promoters (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35852", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.12"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031732", "l": "CCR7 chemokine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16640", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine <=> [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63343", "l": "ATP + L-amino acyl-L-seryl-[protein] <=> (S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018768", "l": "RHOU auto-activates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59938", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+) => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130640", "l": "Recruitment of clathrin coated vesicle by Ii (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018826", "l": "RHOT2 hydrolyzes GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50094", "l": "an N-fatty acyl-taurine + CoA + H(+) => a fatty acyl-CoA + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52212", "l": "acetochlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = ethyl formate + H2O + N-(2-ethyl-6-methylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664983", "l": "Phosphorylated heterodimers of ERBB2 KD mutants recruit GRB2:SOS1 through SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869683", "l": "oxPL binds LBP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166220", "l": "FA anion diffuses laterally to UCP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706336", "l": "Active FLT3 binds to SYK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694555", "l": "Protein M localizes to the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51258", "l": "(9S,16S)-dihydroperoxy-(10E,12Z,14E)-octadecatrienoate => (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549304", "l": "OCT3 mediates renal clearance of organic cations (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102961", "l": "4,4'-diapophytofluene desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54382", "l": "5-hydroxy-alpha-gurjunene + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008807", "l": "carboxyvinyl-carboxyphosphonate phosphorylmutase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093329", "l": "EFNBs bind SDCBP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60846", "l": "a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + diphosphate => a 5'-end diphospho-guanosine in mRNA + GTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16291", "l": "(R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH => (1R,2S)-ephedrine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36242", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O <=> 1-O-alkyl-2-acyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42263", "l": "H(+) + heptanoyl-CoA + malonyl-[ACP] <=> 3-oxononanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045519", "l": "interleukin-23 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27444", "l": "NAD(+) + xylitol <=> D-xylose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0140272", "l": "exogenous protein binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052757", "l": "chondroitin hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32902", "l": "1,8-cineole + O2 + reduced [flavodoxin] <=> 2-endo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730903", "l": "Oligomerization of TRAF6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15847", "l": "4-O-{[(2R)-2-alpha-D-glucosyl-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n H(+) + n UDP => 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008440", "l": "inositol-1,4,5-trisphosphate 3-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972977", "l": "POU5F1 (OCT4), SOX2, NANOG bind the DKK1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004668", "l": "protein-arginine deiminase activity"}, {"i": "RHEA:18089", "l": "H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4(+)"}, {"i": "EC:3.5.3.15", "l": "\"Protein-arginine deiminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624951", "l": "TNPO1 binds KIF17 dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004169", "l": "dolichyl-phosphate-mannose-protein mannosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14026", "l": "H(+) + H2O + sepiapterin => NH4(+) + xanthopterin-B2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56673", "l": "dihydro-4-coumaroyl-CoA + NADP(+) => (E)-4-coumaroyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007926", "l": "ATRX binds DAXX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13015", "l": "an alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210277", "l": "Interaction of PECAM-1 and SHP-1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13999", "l": "2-methylpropanoyl-CoA + CO2 + NADH => 3-methyl-2-oxobutanoate + CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12862", "l": "guanosine + H(+) + H2O => NH4(+) + xanthosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.159"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371590", "l": "HSP70 binds to HSP40:nascent protein (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "59.777908508944456", "identifiers": [{"i": "GO:0015291", "l": "secondary active transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12214", "l": "9H-fluoren-9-one + H(+) + NADPH => 9H-fluoren-9-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102779", "l": "cannabidiolate synthase activity"}, {"i": "RHEA:34411", "l": "cannabigerolate + O2 = cannabidiolate + H2O2"}, {"i": "EC:1.21.3.8", "l": "\"Cannabidiolic acid synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102494", "l": "GA20 2,3-desaturase activity"}, {"i": "MetaCyc:RXN-14317"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697086", "l": "Rifampicin binds Mtb RNAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43582", "l": "AH2 + iminoarginine => A + D-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65341", "l": "acetyl-CoA + L-threonyl-[protein] => CoA + O-acetyl-L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047921", "l": "aminoglycoside 2'-N-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14787", "l": "diphosphate + RNA(n)-3'-uridine ribonucleotide => RNA(n) + UTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62275", "l": "4 (R)-2-hydroxy-3-methylbutyrate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + bassianolide + 8 diphosphate + 8 H(+) + 4 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854303", "l": "TBC1D11 binds RAB6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948757", "l": "AKT phosphorylates MKRN1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52512", "l": "a quinone + trans-4-hydroxy-L-proline = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)"}, {"i": "EC:1.5.5.3", "l": "\"Hydroxyproline dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57829", "l": "dIMP + H2O => 2-deoxy-D-ribose 5-phosphate + hypoxanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814764", "l": "Plasma membrane resorption (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047595", "l": "6-hydroxynicotinate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48904", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP"}, {"i": "RHEA:48908", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP"}, {"i": "EC:2.4.1.255", "l": "\"Protein O-GlcNAc transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865482", "l": "KMT2A (MLL) binds RUNX1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-571316", "l": "Autophosphorylation of IRAK4 bound to the activated TLR7 or 21complex.  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19135", "l": "3,5,3'-triiodothyropyruvate + L-glutamate => 2-oxoglutarate + 3,3',5-triiodo-L-thyronine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5082391", "l": "Trimerization of HSF1 in the nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72631", "l": "Formation of the cap-binding eIF4F complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-354060", "l": "Translocation of RIAM to plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62316", "l": "salicylate + UDP-alpha-D-glucose = 1-O-salicyl-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17474", "l": "GTP + H2O => 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10289", "l": "H2O + L-rhamnono-1,4-lactone => H(+) + L-rhamnonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381109", "l": "IRE1 binds IRE1 forming dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65976", "l": "cholesta-5,7-dien-3beta-ol + hnu = previtamin D3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.36"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11747", "l": "H2O + thiamine triphosphate <=> H(+) + phosphate + thiamine diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18325", "l": "(2E,6E)-farnesyl diphosphate = (+)-amorpha-4,11-diene + diphosphate"}, {"i": "EC:4.2.3.24", "l": "\"Amorpha-4,11-diene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374665", "l": "DCC interaction with SIAH1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50361", "l": "(R)-mandelonitrile + O2 => benzoyl cyanide + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32035", "l": "(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O = (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + H(+)"}, {"i": "EC:3.7.1.17", "l": "\"4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170846", "l": "TGFBR2 recruits TGFBR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798474", "l": "S100A8:S100A9 binds Zn2+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48649", "l": "lipoxin A4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-lipoxin A4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014449", "l": "RHOG binds effectors at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382056", "l": "Crk binds to the active PDGF receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043834", "l": "trimethylamine methyltransferase activity"}, {"i": "MetaCyc:RXN-8102"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388900", "l": "Neurotensin receptors can bind neurotensins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34785", "l": "a 3-oxosteroid + H(+) + NADPH => a 3alpha-hydroxysteroid + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446089", "l": "BP180 interacts extracellularly with Laminin 332 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605797", "l": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14613", "l": "ATP + H2O + taurine(out) = ADP + H(+) + phosphate + taurine(in)"}, {"i": "EC:7.6.2.7", "l": "\"ABC-type taurine transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6793666", "l": "MDM2 translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018814", "l": "RHOT1 hydrolyzes GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662608", "l": "MT2A binds cadmium (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802925", "l": "Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903981", "l": "enterobactin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53014", "l": "chloride + chlorohydroquinone + glutathione disulfide + H(+) => 2,5-dichlorohydroquinone + 2 glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23700", "l": "5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)"}, {"i": "EC:3.5.4.9", "l": "\"Methenyltetrahydrofolate cyclohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2872463", "l": "SLC9C1 exchanges Na+ for H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-500717", "l": "Activation of GRIK3 homomer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3296301", "l": "CCRL2 binds CCL19 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63911", "l": "ATP + H2O + pravastatin(in) <=> ADP + H(+) + phosphate + pravastatin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20563", "l": "CO2 + glycolaldehyde => 3-hydroxypyruvate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12581", "l": "H2O + NAD(+) + tauropine => H(+) + NADH + pyruvate + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36893", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + A + 2 H2O => (9Z,12Z)-octadecadienoyl-CoA + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109857", "l": "MAP2K1 binds MAPK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140851", "l": "fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13534", "l": "H2O + medicarpin + NADP(+) => (3R)-vestitone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59517", "l": "acetylsalicylate + L-lysyl-[protein] => H(+) + N(6)-acetyl-L-lysyl-[protein] + salicylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11338", "l": "deacetoxyvindoline + H(+) + S-adenosyl-L-homocysteine => (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016165", "l": "linoleate 13S-lipoxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44601", "l": "a fatty acid + ATP + H(+) => a fatty acyl-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57097", "l": "AH2 + S-methyl-1-thio-D-xylulose 5-phosphate => 1-deoxy-D-xylulose 5-phosphate + A + methanethiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.48", "l": "\"Cerevisin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17956", "l": "3-hydroxyanthranilate + O2 <=> (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54587", "l": "a guanosine in 18S rRNA + S-adenosyl-L-methionine <=> an N(7)-methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39829", "l": "2-hydroxytetracosanoate + 2 [Fe(III)-cytochrome b5] + H2O => 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + tetracosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785126", "l": "FA core complex assembles at DNA interstrand crosslinks (ICLs) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37202", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051267", "l": "CP2 mannose-ethanolamine phosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37426", "l": "aclacinomycin N + O2 <=> aclacinomycin A + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48452", "l": "ganglioside GA2 (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10988", "l": "H2O + nitrous oxide = 2 e(-) + 2 H(+) + 2 nitric oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58742", "l": "diphosphate + H(+) + psi-UMP => H2O + psi-UTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23658", "l": "3-carboxy-cis,cis-muconate + H(+) => 2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031863", "l": "prostaglandin D2 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5662466", "l": "XYLB phosphorylates D-xylulose (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62543", "l": "2 [Fe(II)cytochrome c] + 3 H(+) + ouabain <=> 2 [Fe(III)cytochrome c] + dihydroouabain"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32692", "l": "(2E)-geranyl diphosphate => (E)-beta-ocimene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170978", "l": "p-FRS2:CRKL binds C3G (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061749", "l": "forked DNA-dependent helicase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10330", "l": "a 2-hydroxycarbonyl + H(+) + NADH => an L-glycol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13570", "l": "ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => beta-D-GalNAc-(1->4)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54724", "l": "N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24774", "l": "chlorophyllide b + H(+) + NADPH => 7(1)-hydroxychlorophyllide a + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43602", "l": "3R-hydroxyeicosanoyl-[ACP] + NADP(+) => 3-oxoeicosanoyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51071", "l": "(2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + pyruvate <=> (3S,5R,10R,12S,14S,15R,16R)-3,5,10,14,15-pentahydroxy-12,16-dimethylicosan-2-one + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10317", "l": "2-oxoglutarate + O2 + thymine => 5-hydroxymethyluracil + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66328", "l": "taurine(out) = taurine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72127", "l": "Formation of the Spliceosomal B Complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62285", "l": "2 ATP + L-proline + L-tryptophan + NADPH => (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + 2 AMP + 2 diphosphate + H(+) + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350396", "l": "DSH binds to DAAM (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858500", "l": "CLEC10A binds Tn-MUC1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14302", "l": "4-pyridoxolactone + H2O => 4-pyridoxate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.15"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112429", "l": "Formation of FACT complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102823", "l": "kaempferol-3-rhamnoside-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-8266"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807008", "l": "PTPRJ dephosphorylates MET (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22028", "l": "acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate"}, {"i": "EC:2.3.1.162", "l": "\"Taxadien-5-alpha-ol O-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034479", "l": "phosphatidylglycerol phospholipase C activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32455", "l": "(-)-vetispiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + solavetivone"}, {"i": "EC:1.14.14.151", "l": "\"Premnaspirodiene oxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668545", "l": "NIK autophosphorylates on T559 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39373", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+) => 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53303", "l": "D-5-[2-(methylsulfanyl)ethyl]hydantoin + H2O <=> H(+) + N-carbamoyl-D-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39568", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51685", "l": "(2E,6E)-farnesyl phosphate + CTP => (2E,6E)-farnesyl diphosphate + CDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51276", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate = (9S)-hydroperoxy-(10E,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27483", "l": "acetone + angelicin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-columbianetin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696146", "l": "AOC2 deaminates TYR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052762", "l": "gellan lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52369", "l": "3'-phosphoadenylyl sulfate + cholesterol => adenosine 3',5'-bisphosphate + cholesterol sulfate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36590", "l": "an aldopyranose + NADP(+) <=> aldono-1,5-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55672", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine = 4-O-([2-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP"}, {"i": "EC:2.4.1.355", "l": "\"Poly(ribitol-phosphate) beta-N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23694", "l": "H2O + maleate => (R)-malate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.18"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52724", "l": "3'-phosphoadenylyl sulfate + an aliphatic desulfo-glucosinolate = adenosine 3',5'-bisphosphate + an omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+)"}, {"i": "EC:2.8.2.38", "l": "\"Aliphatic desulfoglucosinolate sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23335", "l": "(2R)-3-phosphoglycerate + GTP <=> (2R)-3-phospho-glyceroyl phosphate + GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389463", "l": "Proteinase-activated receptors can bind thrombin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2423785", "l": "CR:atREs binds apoE and HSPG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0034617", "l": "tetrahydrobiopterin binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047360", "l": "undecaprenyl-phosphate galactose phosphotransferase activity"}, {"i": "RHEA:11652", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose = alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP"}, {"i": "EC:2.7.8.6", "l": "\"Undecaprenyl-phosphate galactose phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24992", "l": "L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63991", "l": "2-thiocytidine + ATP <=> 2-thiocytidine 5'-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34955", "l": "5-(methylsulfanyl)-D-ribose(in) = 5-(methylsulfanyl)-D-ribose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2530429", "l": "Formation of soluble VTN:C5b-C9  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50193", "l": "L-seryl-[protein] + UDP-alpha-D-xylose => 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390593", "l": "ATP Hydrolysis By Myosin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29004", "l": "H(+)(out) + L-homoserine(in) => H(+)(in) + L-homoserine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380949", "l": "AMPK is dephosphorylated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198563", "l": "IDO1 dioxygenates L-Trp to NFK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0032550", "l": "purine ribonucleoside binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015184", "l": "L-cystine transmembrane transporter activity"}, {"i": "REACT:R-HSA-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13847", "l": "2-hydroxy-3-oxopropanoate + CO2 => dihydroxyfumarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664268", "l": "Opsonized leishmania amastigote binds FCGR3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451311", "l": "Activation of Ca-permeable Kainate receptors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621370", "l": "SYK autophosphorylates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35850", "l": "ATP + sphing-4-enine <=> ADP + H(+) + sphing-4-enine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32164", "l": "ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine => AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60874", "l": "a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(7)-methyl-GDP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49327", "l": "(5R,6S)-5,6-epoxi-capsanthin <=> all-trans-capsorubin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103118", "l": "UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity"}, {"i": "RHEA:17817", "l": "(3R)-hydroxytetradecanoyl-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = H(+) + holo-[ACP] + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine"}, {"i": "EC:2.3.1.191", "l": "\"UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036061", "l": "Defective GLB1 does not hydrolyse linker chain(2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34192", "l": "(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O => (2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55475", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-diene-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50748", "l": "H2O + juglone = naphthalene-1,2,4,8-tetrol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14536", "l": "creatinine + H2O <=> creatine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006050", "l": "MECP2:SIN3A complex binds the promoter of the BDNF gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358789", "l": "Self-ubiquitination of RNF41 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29825", "l": "chloride(out) => chloride(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18142", "l": "NAD(+) + trans-cyclohexane-1,2-diol => 2-hydroxycyclohexan-1-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391935", "l": "DP1 receptor can bind PGD2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66369", "l": "6-methyl-3,7-dioxodecanedioyl-CoA + CoA => 4-methyl-5-oxo-octanedioyl-CoA + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183122", "l": "Factor D cleaves C3b-bound Factor B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62462", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate => 3,4-dihydroxybenzoate + ATP + holo-[aryl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102160", "l": "cyanidin-3-O-glucoside 2-O-glucuronosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66121", "l": "2-oxobutanoate + L-methionine => (2S)-2-aminobutanoate + 4-methylsulfanyl-2-oxobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944254", "l": "Association of procollagen type XXVI (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-265177", "l": "Exocyst complex formation (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44614", "l": "2-methoxy-6-(all-trans-decaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-decaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54765", "l": "5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine => [LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620891", "l": "FOXO3 binds BTG1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27306", "l": "A + D-proline = 1-pyrroline-2-carboxylate + AH2"}, {"i": "EC:1.5.99.13", "l": "\"D-proline dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444433", "l": "Cho transports from the extracellular space to the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19074", "l": "ATP + L-seryl-[I-kappa-B protein] => ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854736", "l": "FLT3LG dimer:FLT3 binds FLT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22560", "l": "(3R)-vestitone + NADP(+) = 2'-hydroxyformononetin + 2 H(+) + NADPH"}, {"i": "EC:1.3.1.45", "l": "\"2'-hydroxyisoflavone reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46394", "l": "4beta,24S-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38660", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15491", "l": "9-riburonosyladenine + H(+) + 2 H2O2 => adenosine + H2O + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64194", "l": "(9Z)-octadecenoate + L-lysine => H2O + N-(9Z-octadecenoyl)-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45791", "l": "(9Z)-hexadecenoyl-CoA + 1,2-dihexadecanoyl-sn-glycerol <=> 1,2-dihexadecanoyl-3-(9Z-hexadecenoyl)-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47016", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 2 A + 3 H2O = [DsrC protein]-dithiol + 2 AH2 + 2 H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44706", "l": "a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a 2,3-saturated acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58464", "l": "a neolactoside nLc4Cer + UDP-N-acetyl-alpha-D-glucosamine = a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265301", "l": "Corticotropin cleavage from POMC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685953", "l": "SIRT6 deacetylates RBBP8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53446", "l": "11beta,17beta-dihydroxyandrost-4-ene-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047763", "l": "caffeate O-methyltransferase activity"}, {"i": "RHEA:20225", "l": "(E)-caffeate + S-adenosyl-L-methionine = (E)-ferulate + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.68", "l": "\"Caffeate O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044466", "l": "glutaryl-CoA hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654573", "l": "Activated FGFR1 binds SHC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11851", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine <=> [thioredoxin]-dithiol + glycine betaine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177479", "l": "Axonal transport of NGF:Trk complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034575", "l": "4-isopropylaniline dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28882", "l": "H(+)(in) + L-tryptophan(in) <=> H(+)(out) + L-tryptophan(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700156", "l": "Active ALK dimer binds IRS1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050642", "l": "2-alpha-hydroxytaxane 2-O-benzoyltransferase activity"}, {"i": "RHEA:18741", "l": "10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA = 10-deacetylbaccatin III + CoA"}, {"i": "EC:2.3.1.166", "l": "\"2-alpha-hydroxytaxane 2-O-benzoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50852", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5220959", "l": "TDG excises 5-formylcytosine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102564", "l": "aurachin C epoxide hydrolase/isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42312", "l": "H(+) + NADP(+) + 2 reduced [adrenodoxin] = NADPH + 2 oxidized [adrenodoxin]"}, {"i": "EC:1.18.1.6", "l": "\"Adrenodoxin-NADP(+) reductase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102252", "l": "cellulose 1,4-beta-cellobiosidase activity (reducing end)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807872", "l": "Active ARF recruits coatomer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15159", "l": "H2O + homogentisate + NADP(+) => 4-hydroxyphenylacetate + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52383", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9681294", "l": "IL6R binds IL6R inhibitors (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433506", "l": "Phosphorylation of APS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671702", "l": "AP1G2 binds HGS and CHMP2A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848314", "l": "IL36:IL1RL2 binds IL1RAP-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5632668", "l": "SMO translocates to the cilium (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59794", "l": "(2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate => H2O + NADP(+) + yersinopine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16892", "l": "2-oxoglutarate + 6-acetamido-3-aminohexanoate <=> 6-acetamido-3-oxohexanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814409", "l": "CK2 phosphorylates PDCL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42158", "l": "5alpha-androstane-3alpha,17beta-diol + NADP(+) => 3alpha-hydroxy-5alpha-androstan-17-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684016", "l": "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 mRNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49589", "l": "L-erythrulose 1-phosphate => D-erythrulose 4-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851919", "l": "Activated MET binds GAB1 and GRB2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205262", "l": "Direct recruitment of PI3K to p-KIT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43259", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23101", "l": "ATP + dAMP => ADP + dADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400267", "l": "BTRC:CUL1:SKP1 (SCF-beta-TrCP1) ubiquitinylates PER proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57268", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP = GMP + H(+) + lactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54804", "l": "2 4-sulfanylbutanoate + NAD(+) = 4,4'-disulfanyldibutanoate + H(+) + NADH"}, {"i": "EC:1.8.1.20", "l": "\"4,4'-dithiodibutanoate disulfide reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48704", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = 12S-HpEPE"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102186", "l": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol-4alpha-methyl oxidase activity"}, {"i": "MetaCyc:RXN-11948"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35448", "l": "(1'S)-averantin + NADP(+) => H(+) + NADPH + norsolorinic acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57225", "l": "glyoxal + GTP => N(2)-(1-hydroxy-2-oxoethyl)-GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22676", "l": "chlorophyllide a + H(+) + NADPH + O2 = 7(1)-hydroxychlorophyllide a + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707505", "l": "Hemes bind to CLEC1B dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35070", "l": "(S)-carnitine(out) <=> (S)-carnitine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23616", "l": "1,2-dihydro-alpha-santonin + NADP(+) = alpha-santonin + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938022", "l": "RUNX1:CBFB binds the NR4A3 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624948", "l": "KIF17 enters the cilium (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37715", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine = 1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36793", "l": "hydroxyurea + L-ornithine => H2O + N(omega)-hydroxy-L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.5", "l": "\"3-oxo-5-alpha-steroid 4-dehydrogenase (acceptor)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044584", "l": "cellodextrin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24620", "l": "NAD(+) + octan-1-ol = H(+) + NADH + octanal"}, {"i": "EC:1.1.1.73", "l": "\"Octanol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54139", "l": "cytidine(48) in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine(48) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57910", "l": "5-phosphooxy-L-glutamyl-tRNA(Gln) + ADP => ATP + L-glutamyl-tRNA(Gln)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236963", "l": "Maturation of phagosome into phagolysosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008787", "l": "allose kinase activity"}, {"i": "RHEA:14805", "l": "ATP + D-allose = ADP + D-allose 6-phosphate + H(+)"}, {"i": "EC:2.7.1.55", "l": "\"Allose kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13053", "l": "L-phenylalanine + pyruvate = 3-phenylpyruvate + L-alanine"}, {"i": "EC:2.6.1.58", "l": "\"Phenylalanine(histidine) transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45782", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + di-(9Z)-octadecenoylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30649", "l": "CDP-1L-myo-inositol + diphosphate => 1D-myo-inositol 3-phosphate + CTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60102", "l": "cyanidin 3-O-beta-D-glucoside + H(+) + UDP => cyanidin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20691", "l": "(E)-caffeate + H(+) + L-quinate => chlorogenate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202466", "l": "Interaction of Bcl10 to CARMA1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380930", "l": "Phosphorylated AMPK binds AMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664406", "l": "IgG:Lma antigens binds FCGR3A:CD3 dimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41021", "l": "1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53905", "l": "ATP + L-threonyl-[tau protein] => ADP + H(+) + O-phospho-L-threonyl-[tau protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050258", "l": "riboflavinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14842", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => ent-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39117", "l": "4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADH => 4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44780", "l": "2-demethylmenaquinol-9 + S-adenosyl-L-methionine = H(+) + menaquinol-9 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26270", "l": "Co-precorrin-2 + 3 H(+) => Co(2+) + precorrin-2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.9.1", "l": "\"Iron:rusticyanin reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13940", "l": "4-sulfobenzoate + NADH + O2 <=> 3,4-dihydroxybenzoate + NAD(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53012", "l": "2,5-dichlorohydroquinone + 2 glutathione = chloride + chlorohydroquinone + glutathione disulfide + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990412", "l": "hercynylselenocysteine lyase activity (selenoneine-forming)"}, {"i": "RHEA:42696", "l": "H2O + hercynylselenocysteine = NH4(+) + pyruvate + selnoneine thione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59083", "l": "bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose <=> 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10096", "l": "a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine"}, {"i": "EC:2.3.1.184", "l": "\"Acyl-homoserine-lactone synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180599", "l": "The Vpu:CD4:beta-TrCP complex recruits SKP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351871", "l": "Caspase-mediated cleavage of Z0-2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21346", "l": "Co-methyl-Co-5-hydroxybenzimidazolylcob(III)amide + H2O => 5-hydroxybenzimidazolylcob(I)amide + H(+) + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693198", "l": "RHOD binds effectors at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109860", "l": "MAP2K1 phosphorylates MAPK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62187", "l": "peregrinol diphosphate <=> diphosphate + labd-13(16),14-diene-9-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.99.1.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13746", "l": "ascopyrone M => microthecin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061708", "l": "tRNA-5-taurinomethyluridine 2-sulfurtransferase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63385", "l": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-octadecyl-2-acetyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35877", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44215", "l": "3-hydroxytetradecanoate + ATP + CoA <=> 3-hydroxytetradecanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433576", "l": "3-dehydrosphinganine + NADPH + H+ => sphinganine + NADP+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849882", "l": "SALMs 1-4 bind reticulon 3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58278", "l": "cyclic hexaadenylate + 6 diphosphate => 6 ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56086", "l": "[Rab1 protein]-L-serine + H(+) + phosphocholine => [Rab1 protein]-O-phosphocholine-L-serine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874083", "l": "p-Y397-PTK2 binds SRC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0043752", "l": "adenosylcobinamide kinase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016977", "l": "chitosanase activity"}, {"i": "MetaCyc:3.2.1.132-RXN"}, {"i": "EC:3.2.1.132", "l": "\"Chitosanase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035983", "l": "Defective HEXB does not cleave the terminal GalNAc from keratan sulfate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640307", "l": "DeHA hydrolyses to 2,3-DKG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11856", "l": "1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29833", "l": "Ni(2+)(out) => Ni(2+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5651789", "l": "LIG1 bound to POLB ligates SSB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2562564", "l": "Caspase-8 processing within TLR4 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015398", "l": "high-affinity secondary active ammonium transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684140", "l": "ATM phosphorylates RBBP8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36218", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-ethanolamine <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40300", "l": "6-deoxyerythronolide B + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => erythronolide B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797961", "l": "CHDH oxidises Cho to BETALD (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655845", "l": "Expression of Acetyl CoA Carboxylase 1 (ACACA, ACC1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30726", "l": "A + 2 ADP + H(+) + NH4(+) + 2 phosphate <=> AH2 + 2 ATP + H2O + hydroxylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187588", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905773", "l": "8-hydroxy-2'-deoxyguanosine DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3204311", "l": "AOX1 oxidises PXL to PDXate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047877", "l": "ephedrine dehydrogenase activity"}, {"i": "RHEA:16289", "l": "(1R,2S)-ephedrine + NAD(+) = (R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH"}, {"i": "EC:1.5.1.18", "l": "\"(-)-ephedrine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783880", "l": "PIPOX oxidises PPCA to P6C (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2172666", "l": "RB1 binds condensin II (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247843", "l": "secretion of WNT ligands (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19550", "l": "H2O + orsellinate depside => H(+) + 2 orsellinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944254", "l": "Association of procollagen type XXVI (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25182", "l": "acetyl-CoA + putrescine => CoA + H(+) + N-acetylputrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005360", "l": "insulin-responsive glucose:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40059", "l": "decanoyl-CoA + H2O = CoA + decanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50327", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373747", "l": "Phosphorylation of nephrin by FYN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19649", "l": "ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)"}, {"i": "EC:6.1.1.12", "l": "\"Aspartate--tRNA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60045", "l": "beta-D-Gal-(1<->1')-Cer + UDP-alpha-D-galactose => alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38380", "l": "(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1856948", "l": "Formation of CRY:PER:Kinase complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10457", "l": "acetyl-CoA + D-maltose => 1-O-acetylmaltose + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41625", "l": "3-sulfinopropanoyl-CoA + H2O => H(+) + propanoyl-CoA + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693092", "l": "Unknown deacetylase deacetylates 7K-BACE1(46-501) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64105", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + O-phospho-L-seryl-[protein] => 1D-myo-inositol hexakisphosphate + O-diphospho-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22192", "l": "(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide"}, {"i": "EC:2.1.2.3", "l": "\"Phosphoribosylaminoimidazolecarboxamide formyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49453", "l": "a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H2O => 6-sulfo-D-quinovose + a 1,2-diacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35615", "l": "hydroxyacetone + NAD(+) = H(+) + methylglyoxal + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15920", "l": "an aldopyranose + NAD(+) <=> aldono-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21741", "l": "2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol => [thioredoxin]-disulfide + H(+) + hydrogen sulfide + pyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030058", "l": "amine dehydrogenase activity"}, {"i": "RHEA:51128", "l": "A + an aliphatic amine + H2O = AH2 + an aldehyde + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44851", "l": "(9Z)-tetradecenoyl-CoA + (R)-carnitine <=> CoA + O-(9Z)-tetradecenoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50370", "l": "3-hydroxy-3-methylbut-1-ene + 2 H2O + NADP(+) => 2-methylbutan-2-ol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37405", "l": "1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10911", "l": "3'-phosphoadenylyl sulfate + glycolithocholate <=> adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392263", "l": "AVP(20-28) binds AVPR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799246", "l": "CHEK1 phosphorylates TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41889", "l": "3-oxotetradecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849085", "l": "ARHGAP35 binds RHOA:GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848023", "l": "Activated PTK6 binds STAP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42037", "l": "chenodeoxycholate + NAD(+) => 7-oxolithocholate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.14"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216069", "l": "Interaction of integrin alphaDbeta2 with fibrin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373087", "l": "Receptor CCR6 binds CCL20 ligand (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865994", "l": "GAB1 binds PTPN11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55483", "l": "ent-cassa-12,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> ent-3beta-hydroxycassa-12,15-dien-2-one + 3 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57797", "l": "4-nitrotoluene + NADH + O2 => 4-methylcatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668023", "l": "TPST1,2 transfer SO4(2-) from PAPS to FVIII (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40220", "l": "H2O + malonyl-CoA => CoA + H(+) + malonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23501", "l": "H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+) => 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222469", "l": "SodC reduces superoxide to H2O2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18716", "l": "2-oxoglutarate + UDP-N-acetylbacillosamine <=> L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-D-gluco-hex-4-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46991", "l": "(R)-6-hydroxynicotine + O2 <=> 6-hydroxy-N-methylmyosmine + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49451", "l": "beta-D-Manp-(1->2)-beta-D-Manp-(1->2)-D-Manp + H2O <=> alpha-D-mannopyranose + beta-D-mannopyranosyl-(1->2)-D-mannopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56292", "l": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] = 4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.75", "l": "\"Fenbendazole monooxygenase (4'-hydroxylating)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044693", "l": "trehalose:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008785", "l": "alkyl hydroperoxide reductase activity"}, {"i": "REACT:R-HSA-1222526", "l": "AhpC reduces peroxidated lipids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000994", "l": "RNA polymerase III core binding"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0016721", "l": "oxidoreductase activity, acting on superoxide radicals as acceptor"}, {"i": "EC:1.15.-.-", "l": "\"Acting on superoxide as acceptor\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046553", "l": "D-malate dehydrogenase (decarboxylating) activity"}, {"i": "RHEA:18365", "l": "(R)-malate + NAD(+) = CO2 + NADH + pyruvate"}, {"i": "EC:1.1.1.83", "l": "\"D-malate dehydrogenase (decarboxylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58951", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine <=> 4-O-([3-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18265", "l": "6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD(+) = 6-oxocyclohex-1-ene-1-carbonyl-CoA + H(+) + NADH"}, {"i": "EC:1.1.1.368", "l": "\"6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399950", "l": "Phosphorylation of cofilin by LIMK-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5432825", "l": "HMGB1 binds TLR4:LY96 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16696", "l": "alpha-pinene oxide <=> (Z)-2-methyl-5-isopropylhexa-2,5-dienal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17688", "l": "H(+) + uracil 5-carboxylate <=> CO2 + uracil"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33523", "l": "ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + H2O = acetate + ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29501", "l": "(+)-alpha-barbatene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163625", "l": "Glucagon binds to Glucagon receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17295", "l": "H2O + NAD(+) + precorrin-3B => 2 H(+) + NADH + O2 + precorrin-3A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32660", "l": "(6E)-8-hydroxygeraniol + 2 NADP(+) => (6E)-8-oxogeranial + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60029", "l": "(2E)-geranyl diphosphate + H2O => 4-terpineol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27468", "l": "ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) <=> ADP-D-glycero-beta-D-manno-heptose + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15751", "l": "AH2 + phenylglyoxylate => (S)-mandelate + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53371", "l": "5,6-dihydrouridine(17) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(17) in tRNA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097079", "l": "selenite:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814778", "l": "GDPD3 hydrolyzes LysoPtdCho (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15456", "l": "S-adenosyl-L-methionine + sarcosine <=> H(+) + N,N-dimethylglycine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990649", "l": "inositol-1,2,4,5-tetrakisphosphate 5-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27779", "l": "4-hydroxy-3-all-trans-octaprenylbenzoate + H(+) => 2-all-trans-octaprenylphenol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630055", "l": "NTHL1 D239Y does not cleave dihydrouracil (DHU) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29147", "l": "2 H(+)(in) + nitrate + ubiquinol-8 = 2 H(+)(out) + H2O + nitrite + ubiquinone-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187382", "l": "Degradation of ubiquitinated SMAD3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451481", "l": "TLR7 binds to recognized ligands (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37100", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O => a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20000", "l": "H2O + phosphoenolpyruvate <=> phosphate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40463", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = (9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357828", "l": "RIPK1 is cleaved by CASP8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168888", "l": "Alpha1-Microglobulin binds heme (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047569", "l": "3-oxoadipate CoA-transferase activity"}, {"i": "RHEA:12048", "l": "3-oxoadipate + succinyl-CoA = 3-oxoadipyl-CoA + succinate"}, {"i": "EC:2.8.3.6", "l": "\"3-oxoadipate CoA-transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879674", "l": "CD97 binds CD55 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38068", "l": "2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA => 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65043", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + a tri-(9Z,12Z-octadecadienoyl)-monolysocardiolipin <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080106", "l": "7-methylthiopropyl glucosinolate S-oxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35993", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21790", "l": "CO2 + formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874979", "l": "ACBD3 binds GOLGB1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388468", "l": "AVP(20-28) binds AVPR1A,B (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63970", "l": "atromentin + 2 H2O => 2 3-(4-hydroxyphenyl)pyruvate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59796", "l": "dodecanoyl-CoA + L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] = CoA + H(+) + N(6)-dodecanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54489", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => 1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41897", "l": "(2E)-tetradecenoyl-[ACP] + H(+) + NADPH => NADP(+) + tetradecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52895", "l": "H2O + NADP(+) + nitrosobenzene <=> H(+) + NADPH + nitrobenzene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39468", "l": "(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + NADPH => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38927", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30402", "l": "alpha-carotene + O2 + reduced [NADPH--hemoprotein reductase] <=> alpha-cryptoxanthin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848339", "l": "PNPLA5 hydrolyzes TAG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15765", "l": "adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)"}, {"i": "RHEA:15769", "l": "adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)"}, {"i": "EC:2.7.1.156", "l": "\"Adenosylcobinamide kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432946", "l": "PARVB/Affixin interacts with alpha PIX (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45225", "l": "(3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA => (2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38479", "l": "N(alpha)-methyl-L-histidine + S-adenosyl-L-methionine = H(+) + N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981621", "l": "Neuroglobin:oxygen dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27496", "l": "S-adenosyl-L-methionine + tricetin <=> 3'-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18699", "l": "(4-hydroxyphenyl)acetaldehyde + CO2 => 3-(4-hydroxyphenyl)pyruvate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12620", "l": "ATP + N-acetyl-alpha-D-galactosamine <=> ADP + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30040", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADPH + O2 => benzene-1,2,4-triol + CO2 + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19069", "l": "(R)-S-lactoylglutathione = glutathione + methylglyoxal"}, {"i": "EC:4.4.1.5", "l": "\"Lactoylglutathione lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44712", "l": "a 1,2-diacylglycerol + H2O = a 1-acylglycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419223", "l": "5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) + L-aspartate + ATP => 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) + adenosine 5'-diphosphate + orthophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043023", "l": "ribosomal large subunit binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41511", "l": "L-ornithine + NADPH + O2 <=> H2O + N(5)-hydroxy-L-ornithine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69127", "l": "Formation of the Flap Intermediate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54020", "l": "L-lysyl-[protein] + propanoyl-CoA = CoA + H(+) + N(6)-propanoyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37973", "l": "(9Z)-octadecenoyl-CoA + 2 H2O + NADP(+) => H(+) + NADPH + O2 + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5625424", "l": "The retrograde IFT train dissociates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604722", "l": "Activation of proMMP9 by proteases (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44119", "l": "eicosan-1-ol + hexadecanoyl-CoA <=> CoA + eicosanyl hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35848", "l": "ATP + sphing-4-enine => ADP + H(+) + sphing-4-enine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174963", "l": "NAT1 acetylation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110035", "l": "rDNA spacer replication fork barrier binding, bending"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4341048", "l": "SUMOylation of RXRA with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534378", "l": "Hv1 Mediated H+ Permeability (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015170", "l": "propanediol transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54749", "l": "ATP + CoA + firefly L-luciferin => AMP + diphosphate + L-firefly luciferyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961920", "l": "E2F1 binds the CDK1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51903", "l": "H2O + N(1)-acetylspermidine <=> acetate + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63163", "l": "H2O + N-(15Z-tetracosenoyl)-taurine <=> (15Z)-tetracosenoate + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10203", "l": "butanoate + NAD(+) <=> (2E)-2-butenoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9647977", "l": "ICMT methylates S-Farn RAS proteins (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5195402", "l": "CDK1 phosphorylates LPIN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20359", "l": "3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) => 3-phenylpropanoate + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21792", "l": "NADP(+) + propan-2-ol = acetone + H(+) + NADPH"}, {"i": "EC:1.1.1.80", "l": "\"Isopropanol dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034877", "l": "isonicotinate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800380", "l": "PTPRD binds IL1RAP-1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17348", "l": "(S)-methylmalonyl-CoA + H2O <=> CoA + H(+) + methylmalonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198599", "l": "AKT phosphorylates MDM2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52456", "l": "testosterone + UDP-alpha-D-glucuronate = H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21460", "l": "benzoin = 2 benzaldehyde"}, {"i": "EC:4.1.2.38", "l": "\"Benzoin aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19951", "l": "7,8-dihydropteroate + diphosphate => (7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34617", "l": "H(+) + hydrogencarbonate + methylphosphonate => 2-hydroxyethylphosphonate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5340214", "l": "CYGB binds O2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55848", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA = [(2->6)-alpha-D-glucosyl-(1->4)-N,7-O-diacetyl-alpha-D-neuraminosyl](n) + n CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61401", "l": "ATP + N(6)-(D-ribulosyl)-L-lysine => ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211405", "l": "Anthrax lef cleaves target cell MAP2K6 (MEK6) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448661", "l": "IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682826", "l": "LGI1 binds ADAM11 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51254", "l": "(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44017", "l": "2,6,10,14-tetramethylpentadecanal + H2O + NAD(+) => 2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26334", "l": "2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O => 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20188", "l": "a CMP-N-acyl-beta-neuraminate + H2O <=> an N-acylneuraminate + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43337", "l": "H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + n Na(+)(in) => CO2 + N(6)-biotinyl-L-lysyl-[protein] + n Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23142", "l": "D-ribose 5-phosphate + H(+) + nicotinamide => beta-nicotinamide D-ribonucleotide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2130731", "l": "Formation of COPII vesicle (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.-", "l": "\"Omega peptidases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28328", "l": "D-glucuronate + H(+) + wogonin => H2O + wogonin 7-O-beta-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17427", "l": "acetyl-CoA + CO2 + NADPH => CoA + NADP(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43833", "l": "5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA => 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52767", "l": "(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O <=> (E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675417", "l": "PEBP1 binds activated RAF1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784598", "l": "NPPA(124-151) binds NPR1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13727", "l": "CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate => acetyl-CoA + alpha-D-glucosamine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390846", "l": "D2D3,4 bind to DA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730862", "l": "Autophosphorylation of LYN kinase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20716", "l": "H(+) + H2O + S-adenosyl-L-homocysteine = NH4(+) + S-inosyl-L-homocysteine"}, {"i": "EC:3.5.4.28", "l": "\"S-adenosylhomocysteine deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42878", "l": "H(+) + N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine => S-adenosyl 3-(methylsulfanyl)propylamine + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190519", "l": "Internalization of gap junction plaques (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28684", "l": "L-aspartate + ubiquinone-8 => iminosuccinate + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39819", "l": "2 [Fe(II)-cytochrome b5] + docosanoate + 2 H(+) + O2 = 2-hydroxydocosanoate + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12335", "l": "ATP + Fe(3+)(out) + H2O <=> ADP + Fe(3+)(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0042302", "l": "structural constituent of cuticle"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34107", "l": "glycine + H(+) + hexadecanoyl-CoA = 1-deoxymethyl-3-dehydrosphinganine + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69173", "l": "Joining of adjacent Okazaki fragments (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030748", "l": "amine N-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63019", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenamide + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28509", "l": "alpha-Kdo-(2->6)-lipid IVA + ATP <=> 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4332235", "l": "CBL binds TGFBR2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14638", "l": "3'-phosphoadenylyl sulfate + a thiol => adenosine 3',5'-bisphosphate + H(+) + S-alkyl thiosulfate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090438", "l": "camelliol C synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59886", "l": "4-chloro-L-lysine + CO2 + H2O + succinate => 2-oxoglutarate + chloride + H(+) + L-lysine + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019874", "l": "6-aminohexanoate-cyclic-dimer hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37130", "l": "2-oxoglutarate + dioxidophosphate + H2O2 <=> CO2 + H(+) + phosphonate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43354", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol(out) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956639", "l": "RUNX1 binds YAP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15003", "l": "5-dehydro-D-fructose + H(+) + NADPH => keto-L-sorbose + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42501", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) => 6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65669", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontenoyl)-sphing-4-enine => a diacylglycerol + an N-(32-(9Z,12Z-octadecadienoyloxy)-dotriacontenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50242", "l": "n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O => [hyaluronan](n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805479", "l": "TP53RK phosphorylates TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928639", "l": "p-EFNB binds GRB4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31121", "l": "(2E)-2-methylbut-2-enoyl-CoA + H2O => (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43969", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871260", "l": "YAP1 binds TEAD2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28706", "l": "Cu(2+)(in) <=> Cu(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55039", "l": "an N,N-dimethylornithine lipid + S-adenosyl-L-methionine <=> an N,N,N-trimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60976", "l": "(E)-4-hydroxynon-2-en-1-ol + NAD(+) = (E)-4-hydroxynon-2-enal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16925", "l": "(E)-caffeoyl-CoA + S-adenosyl-L-methionine = (E)-feruloyl-CoA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.104", "l": "\"Caffeoyl-CoA O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54412", "l": "a 3-oxo-5beta-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76466", "l": "CYP4A11 12-hydroxylates DDCX (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31656", "l": "4-deoxy-Delta(4)-beta-D-GlcpA2S-(1->3)-beta-D-GalpNAc + H2O => 5-dehydro-4-deoxy-2-O-sulfo-D-glucuronate + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44387", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + dodecanoyl-CoA <=> 1-heptadecanoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30060", "l": "(S)-dihydroorotate + fumarate => orotate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693356", "l": "CEMIP hydrolyses HA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46034", "l": "(2S)-hydroxytetradecanoate + H2O => H2O2 + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203611", "l": "N-myristoylation of eNOS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64060", "l": "(S)-phenylacetylcarbinol + NAD(+) = 1-phenyl-1,2-propanedione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132283", "l": "Factor H binds to host cell surface (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10652", "l": "a long-chain fatty aldehyde + H2O + NAD(+) = a long-chain fatty acid + 2 H(+) + NADH"}, {"i": "EC:1.2.1.48", "l": "\"Long-chain-aldehyde dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31607", "l": "rhodopin = all-trans-lycopene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32478", "l": "glycine + 3 S-adenosyl-L-methionine <=> glycine betaine + 3 H(+) + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "70.769338388976067", "identifiers": [{"i": "GO:0015276", "l": "ligand-gated ion channel activity"}, {"i": "REACT:R-HSA-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22842", "l": "D-glutamate + NH4(+) => D-glutamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110491", "l": "DRheb is inhibited by the TSC1/2 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68637", "l": "CDC6 protein is synthesized under the control of E2F transcription factors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30879", "l": "H2O + NAD(+) + prop-2-ynal = 2 H(+) + NADH + propynoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18915", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+) => a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696947", "l": "USP47 deubiquitinates POLB (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28062", "l": "alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}, {"i": "EC:2.4.99.13", "l": "\"(Kdo)-lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59149", "l": "ATP + CoA + marinolate C => AMP + diphosphate + marinoloyl-CoA C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41122", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-990489", "l": "Kinesin-13 is a dimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201622", "l": "Caspase-mediated cleavage of gelsolin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23998", "l": "a ribonucleoside 5'-phosphate + diphosphate + H(+) => a ribonucleoside 5'-triphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199093", "l": "CXADR binds to AMICA1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781953", "l": "YOD1 binds VCP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805640", "l": "AKT phosphorylates KAT6A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948651", "l": "miR-106a,(miR106b) microRNA binds CNOT6L mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16543", "l": "(3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin => 9-cis-violaxanthin + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029449", "l": "Phosphorylation of SYK by Src kinases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029456", "l": "RAC1 and CDC42 activate PAK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61496", "l": "an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693347", "l": "HTR1A binds 5HT (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30544", "l": "(S)-carnitine + ATP + CoA => (S)-carnitinyl-CoA + ADP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982017", "l": "Active G alpha (q) binds RGS proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730863", "l": "Phosphorylation of CARMA1 by PKC-theta (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29498", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> beta-eudesmol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42945", "l": "cytidine(40) in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine(40) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57800", "l": "2,3-dinitrotoluene + NADH + O2 = 4-methyl-3-nitrocatechol + H(+) + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57692", "l": "2 cob(II)inamide--[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] = 2 cob(I)inamide--[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49561", "l": "D-sedoheptulose 7-phosphate => (R)-demethyl-4-deoxygadusol + H(+) + H2O + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59187", "l": "2,4-diacetylphloroglucinol + H2O <=> 2-acetylphloroglucinol + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17291", "l": "beta-D-fructose 6-phosphate + phosphate => beta-D-fructose 2,6-bisphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265456", "l": "NPC1L1 binds ezetimibe (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28857", "l": "H(+)(out) + melibiose(out) => H(+)(in) + melibiose(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65893", "l": "4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate => H2O + xanthurenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25527", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> 9alpha-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50490", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695834", "l": "Constitutive phosphorylation of FLT3 mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3134800", "l": "STING dimerization (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47944", "l": "(2E)-geranyl diphosphate + H2O = (2E)-geranyl phosphate + H(+) + phosphate"}, {"i": "EC:3.6.1.68", "l": "\"Geranyl diphosphate phosphohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13396", "l": "diphosphate + nicotinate beta-D-ribonucleotide <=> 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685953", "l": "SIRT6 deacetylates RBBP8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694583", "l": "ABHD4 hydrolyses NAPE (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350604", "l": "Agmatine + H2O <=> putrescine + urea (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045140", "l": "inositol phosphoceramide synthase activity"}, {"i": "RHEA:64536", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base"}, {"i": "MetaCyc:RXN3O-581"}, {"i": "EC:2.7.1.227", "l": "\"Inositol phosphorylceramide synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53558", "l": "18-hydroxy-(9R,10S)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9R,10S)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-481044", "l": "Surface deployment of platelet alpha granule membrane components (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051575", "l": "5'-deoxyribose-5-phosphate lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605595", "l": "Hexosaminidase A cleaves GalNAc from GM2 to form GM3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654404", "l": "Activated FGFR2 binds SHC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60665", "l": "H2O + NADPH => NADH + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59163", "l": "ATP + docosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] <=> AMP + diphosphate + docosanoyl-[(phenol)carboxyphthiodiolenone synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28926", "l": "H(+)(in) + L-phenylalanine(in) <=> H(+)(out) + L-phenylalanine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43493", "l": "7(1)-hydroxychlorophyll a + NADP(+) => chlorophyll b + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58503", "l": "glycine betaine + H(+) + NADH + O2 <=> glyoxylate + H2O + NAD(+) + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141409", "l": "Mad1 binds kinetochore (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34743", "l": "15-methylhexadecasphinganine 1-phosphate = 13-methyltetradecanal + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106100", "l": "beta-pinacene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604712", "l": "Initial activation of proMMP7 by trypsin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15477", "l": "3'-phosphoadenylyl sulfate + 5beta-scymnol = 5beta-scymnol sulfate + adenosine 3',5'-bisphosphate + H(+)"}, {"i": "EC:2.8.2.32", "l": "\"Scymnol sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788623", "l": "p-Y-STATs translocate to nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62247", "l": "a cytidine(6-4)thymidine in DNA <=> a cytidine-thymine dinucleotide in DNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57390", "l": "(13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008531", "l": "riboflavin kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032775", "l": "YAP1 binds TEAD1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371591", "l": "Trimerization of cytosolic HSF1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58259", "l": "H2O + O-(ADP-D-ribosyl)-L-seryl-[protein] <=> ADP-D-ribose + L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29785", "l": "ADP + H(+) + L-cysteine(out) + phosphate => ATP + H2O + L-cysteine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043333", "l": "2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity"}, {"i": "MetaCyc:2-OCTAPRENYL-METHOXY-BENZOQ-METH-RXN"}, {"i": "EC:2.1.1.201", "l": "\"2-methoxy-6-polyprenyl-1,4-benzoquinol methylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061810", "l": "NAD glycohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29572", "l": "H(+)(in) + L-idonate(in) => H(+)(out) + L-idonate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609741", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2D (GRIN2D) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20835", "l": "ATP + guanine(out) + H2O <=> ADP + guanine(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25571", "l": "ATP + beta-D-ribosylnicotinate <=> ADP + H(+) + nicotinate beta-D-ribonucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66710", "l": "2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446694", "l": "IRAK4 phosphorylates IRAK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37529", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9631065", "l": "Substrate translocates into late endosomal lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033300", "l": "dehydroascorbic acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017060", "l": "3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity"}, {"i": "REACT:R-HSA-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654623", "l": "Activated FGFR3 binds FRS3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72619", "l": "eIF2:GTP is hydrolyzed, eIFs are released  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052851", "l": "ferric-chelate reductase (NADPH) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23515", "l": "alpha,alpha-trehalose + phosphate <=> beta-D-glucose 1-phosphate + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27547", "l": "anthranilate + FADH2 + O2 => 3-hydroxyanthranilate + FAD + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35215", "l": "H2O + XDP = H(+) + phosphate + XMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31465", "l": "beta-D-glucosyl crocetin + UDP => crocetin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64739", "l": "4-hydroxynonanal + NADP(+) <=> (E)-4-hydroxynon-2-enal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52812", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O = (9Z,12Z)-octadecadienoate + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66281", "l": "solanidine + UDP-alpha-D-glucose => H(+) + solanidine 3-O-beta-D-glucopyranoside + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042018", "l": "interleukin-22 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39035", "l": "an omega-hydroxy fatty acid + NAD(+) = an omega-oxo fatty acid + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990269", "l": "RNA polymerase II C-terminal domain phosphoserine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662891", "l": "pheomelanin formation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16880", "l": "3-sulfino-L-alanine + H(+) <=> CO2 + hypotaurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.173", "l": "\"Rhamnogalacturonan galacturonohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24236", "l": "2 [Fe(III)cytochrome c] + H2O + trimethylamine = 2 [Fe(II)cytochrome c] + 3 H(+) + trimethylamine N-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17750", "l": "A + H2O + quinoline => AH2 + quinolin-2(1H)-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57564", "l": "(+)-cis-trans-nepetalactol + O2 + reduced [NADPH--hemoprotein reductase] = 7-deoxyloganetic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16948", "l": "(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2855047", "l": "Hydrolysis of internal thioester in C4b (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22585", "l": "2 H(+) + heme b => Fe(2+) + protoporphyrin IX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084507", "l": "Laminin-111 binds endostatin dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59870", "l": "4-(2,4-dichlorophenoxy)butanoyl-L-glutamine + AMP + diphosphate + H(+) => 4-(2,4-dichlorophenoxy)butanoate + ATP + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102451", "l": "kaempferide 3-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-13937"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34368", "l": "acrylamide + H2O => acrylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199583", "l": "KIR2DS2 interacting with HLA-C group 1 (Cw3) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53590", "l": "16-oxoresolvin D2 + H(+) + NADH => NAD(+) + resolvin D2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072320", "l": "volume-sensitive chloride channel activity"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0016411", "l": "acylglycerol O-acyltransferase activity"}, {"i": "REACT:R-HSA-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Homo sapiens)"}, {"i": "REACT:R-HSA-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865605", "l": "BRWD1 binds SMARCA4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50983", "l": "prostaglandin E1(out) <=> prostaglandin E1(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29940", "l": "H(+)(in) + phosphate(in) => H(+)(out) + phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33056", "l": "guanosine 3'-diphosphate 5'-triphosphate + H2O => diphosphate + GTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57599", "l": "(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-2-hydroxyeriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11062", "l": "AMP + diphosphate + L-isoleucyl-tRNA(Ile) => ATP + L-isoleucine + tRNA(Ile)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16970", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-4-dehydro-beta-L-rhamnose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10216", "l": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase]"}, {"i": "EC:2.7.11.23", "l": "\"[RNA-polymerase]-subunit kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8873850", "l": "STARD5 binds DCA, LCA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017168", "l": "5-oxoprolinase (ATP-hydrolyzing) activity"}, {"i": "MetaCyc:5-OXOPROLINASE-ATP-HYDROLYSING-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19281", "l": "(7S)-marmesin + O2 + reduced [NADPH--hemoprotein reductase] = acetone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + psoralen"}, {"i": "EC:1.14.14.141", "l": "\"Psoralen synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944240", "l": "Association of procollagen type III (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5339535", "l": "GLTPD1 transports C1P from plasma membrane to Golgi membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42721", "l": "S-adenosyl-L-methionine + uridine(2552) in 23S rRNA => 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25163", "l": "2-oxoglutarate + L-ornithine <=> L-glutamate + L-glutamate 5-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65063", "l": "NADP(+) + taurochenodeoxycholate <=> 7-oxotaurolithocholate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34475", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate"}, {"i": "EC:2.5.1.32", "l": "\"15-cis-phytoene synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0120284", "l": "tryptophan binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33039", "l": "4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin = 2-oxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.15.9", "l": "\"Spheroidene monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45369", "l": "H2O + N-(9Z-octadecenoyl)-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + (9Z)-octadecenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.24"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42769", "l": "a (2S)-2-hydroxycarboxylate + NADP(+) => a 2-oxocarboxylate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928615", "l": "EFNBs bind SFKs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17937", "l": "dihydroxyacetone phosphate = methylglyoxal + phosphate"}, {"i": "EC:4.2.3.3", "l": "\"Methylglyoxal synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56862", "l": "a 2-oxo-3-(phosphooxy)propyl medium-chain 3-oxoalkanoate + holo-[ACP] => a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904408", "l": "melatonin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63330", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 2-(9Z-octadecenoyl)-glycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004712", "l": "protein serine/threonine/tyrosine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63386", "l": "1-O-octadecyl-2-acetyl-sn-glycerol + H(+) + phosphocholine => 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20022", "l": "2-oxoglutarate + deoxyamidinoproclavaminate + O2 => amidinoproclavaminate + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0032393", "l": "MHC class I receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34889", "l": "selenate(out) => selenate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59473", "l": "2',3'-cGAMP + H2O => Gp(2'-5')Ap(3') + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58800", "l": "3',3'-cGAMP + H2O = 5'-pApG-3' + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15299", "l": "3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18639", "l": "H(+) + NADPH => H2 + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42039", "l": "chenodeoxycholate + NAD(+) <=> 7-oxolithocholate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60383", "l": "L-dehydroascorbate(out) <=> L-dehydroascorbate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9008043", "l": "MAPK8 phosphorylation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2514831", "l": "Fibrillin-1 degradation by MMP14 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19412", "l": "cholate + NAD(+) <=> 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46921", "l": "(E)-cinnamate + H(+) => CO2 + styrene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21667", "l": "4-nitrophenyl phosphate + H2O <=> 4-nitrophenol + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618093", "l": "ATP hydrolysis by HSP90 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68914", "l": "DNA polymerase alpha:primase binds at the origin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109639", "l": "Formation of the closed pre-initiation complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050207", "l": "plasmanylethanolamine desaturase activity"}, {"i": "RHEA:22956", "l": "1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 [Fe(III)-cytochrome b5] + 2 H2O"}, {"i": "EC:1.14.19.77", "l": "\"Plasmanylethanolamine desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60218", "l": "CO2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31973", "l": "10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP(+) => 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54391", "l": "1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848774", "l": "PTK6 binds DOK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203774", "l": "Interaction of Csk with PAG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20167", "l": "an alcohol + H(+) + N(5)-acyl-L-ornithine => H2O + N(5)-acyl-L-ornithine ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617492", "l": "EGR2 (KROX20) activates HOXB2 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44840", "l": "(R)-carnitine + octadecanoyl-CoA = CoA + O-octadecanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63221", "l": "7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA + S-adenosyl-L-methionine => 5'-deoxyadenosine + archaeosine(15) in tRNA + 2 H(+) + L-1-piperideine-6-carboxylate + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14347", "l": "CO2 + tyramine => H(+) + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9691174", "l": "RAC1 binds effectors at the ER membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64254", "l": "CoA + H(+) + N-tetradecanoylglycine => glycine + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222363", "l": "MsrA/B reduces peptide-methionine S/R-sulfoxides (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9706399", "l": "RHOBTB3 hydrolyzes ATP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33932", "l": "all-trans-zeaxanthin + O2 => (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.6", "l": "\"Beta-ureidopropionase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19703", "l": "a flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside] + H(+) + UDP => a flavonol 3-O-glycoside + UDP-alpha-D-xylose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55152", "l": "H(+) + L-prolyl-[peptidyl-carrier protein] + 2 oxidized [electron-transfer flavoprotein] = (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 reduced [electron-transfer flavoprotein]"}, {"i": "EC:1.3.8.14", "l": "\"L-prolyl-[peptidyl-carrier protein] dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396007", "l": "IRF3 is phosphorylated by TBK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24872", "l": "5'-deoxyadenosine + phosphate <=> 5-deoxy-alpha-D-ribose 1-phosphate + adenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549355", "l": "CRY proteins stabilize unphosphorylated BMAL1:CLOCK,NPAS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018449", "l": "1-phenylethanol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43938", "l": "androst-4-ene-3,17-dione => androst-5-ene-3,17-dione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17133", "l": "ATP + L-seryl-[tyrosine-3-monooxygenase] = ADP + H(+) + O-phospho-L-seryl-[tyrosine-3-monooxygenase]"}, {"i": "EC:2.7.11.6", "l": "\"[Tyrosine 3-monooxygenase] kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42266", "l": "3-oxodecanoyl-[ACP] + CO2 + CoA => H(+) + malonyl-[ACP] + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43021", "l": "L,L-cystathionine => 2-aminoprop-2-enoate + L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990206", "l": "jasmonyl-Ile conjugate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40490", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38338", "l": "(20S)-ginsenoside Rb1 + 2 H2O <=> (20S)-ginsenoside Rg3 + 2 D-glucose"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0003916", "l": "DNA topoisomerase activity"}, {"i": "EC:5.6.2.-", "l": "\"Enzymes altering nucleic acid conformation\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625465", "l": "E2-mediated FOS gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028583", "l": "Phosphorylation of YAP by LATS2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789185", "l": "Chloride ion and N-acyl group react to chloramide (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983153", "l": "E1 mediated ubiquitin activation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45980", "l": "3-oxochol-4-en-22-oyl-CoA + H(+) + NADH + O2 = 9alpha-hydroxy-3-oxochol-4-en-22-oyl-CoA + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2473596", "l": "Collagen type I degradation by MMP15 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161790", "l": "20cooh-LTB4 is converted to 18cooh-LTB4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63008", "l": "(6Z)-octadecenamide + H2O = (6Z)-octadecenoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17606", "l": "ATP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine => ADP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005136", "l": "interleukin-4 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202466", "l": "Interaction of Bcl10 to CARMA1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24539", "l": "L-tryptophan + O2 <=> N-formyl-L-kynurenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-421836", "l": "trans-Golgi Network Derived Vesicle Uncoating (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13628", "l": "A + H2O + N(6)-dimethylallyladenine <=> 3-methyl-2-butenal + adenine + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18306", "l": "acetyl-CoA + N-acetylneuraminate => CoA + N-acetyl-4-O-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21578", "l": "2-methylcholine + CO2 => carnitine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451283", "l": "kainate receptor binds glutamate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-912790", "l": "CBL binds CRK (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008977", "l": "prephenate dehydrogenase (NAD+) activity"}, {"i": "RHEA:13869", "l": "NAD(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH"}, {"i": "EC:1.3.1.12", "l": "\"Prephenate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36367", "l": "(S)-alpha-hydroxyglutarate-gamma-lactone + H2O = 2-hydroxyglutarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110380", "l": "Dissociation of LIG3:XRCC1 complex from the BER site (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102200", "l": "N-acetylphosphatidylethanolamine-hydrolysing phospholipase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701485", "l": "Active ALK binds JAK3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14633", "l": "ATP + H2O + Na(+)(in) = ADP + H(+) + Na(+)(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33272", "l": "a triacyl-sn-glycerol + H2O => a 1,2-diacyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-165162", "l": "Phosphorylation of TSC2 by PKB (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051401", "l": "CH domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49092", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951644", "l": "Release of mature NEDD8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62750", "l": "(S)-2-methylbutanoate + H(+) + monacolin J => H2O + lovastatin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31653", "l": "5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine => beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34542", "l": "S-adenosyl-L-methionine + tellurite <=> methanetellurite + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20997", "l": "(2Z,4E)-2-aminomuconate + H2O => (3E)-2-oxohex-3-enedioate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18331", "l": "(1S,5S)-sabinone + H(+) + NADH => (1S,3R,5S)-sabinol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47936", "l": "4-hydroxybenzaldehyde + H2O + NADP(+) = 4-hydroxybenzoate + 2 H(+) + NADPH"}, {"i": "EC:1.2.1.96", "l": "\"4-hydroxybenzaldehyde dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904047", "l": "S-adenosyl-L-methionine binding"}, {"i": "REACT:R-HSA-947535", "l": "Cyclisation of GTP to precursor Z (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045504", "l": "dynein heavy chain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-560473", "l": "Expression of ANGPTL4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37511", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39064", "l": "NADP(+) + scyllo-inositol => H(+) + NADPH + scyllo-inosose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685242", "l": "CHEK1 phosphorylates BRCA2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71495", "l": "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10480", "l": "2-oxoglutarate + 4-hydroxy-L-glutamate = 4-hydroxy-2-oxoglutarate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047088", "l": "dihydrosanguinarine 10-monooxygenase activity"}, {"i": "RHEA:10528", "l": "dihydrosanguinarine + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxydihydrosanguinarine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.100", "l": "\"Dihydrosanguinarine 10-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624948", "l": "KIF17 enters the cilium (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14681", "l": "2 2-aminophenol + A + O2 = 2-aminophenoxazin-3-one + AH2 + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34965", "l": "Na(+)(out) => Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60465", "l": "2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) => 2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168858", "l": "Palmitoylation of cysteine residues on HA in the cis-Golgi network (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71495", "l": "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004664", "l": "prephenate dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428750", "l": "Gq activation by TP receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50106", "l": "CoA + H(+) + N-tetradecanoyl-taurine => taurine + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029468", "l": "Conversion of PA into DAG by PAP-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804100", "l": "HMGB1 binds LPS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004111", "l": "creatine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388605", "l": "POMC(138-176) binds MC2R (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17239", "l": "diphosphate + FAD => ATP + FMN + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62906", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc derivative + GDP + H(+) => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102407", "l": "sn-2-glycerol-3-phosphate C22:0-DCA-CoA acyl transferase activity"}, {"i": "MetaCyc:RXN-13734"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783552", "l": "OSM binds LIFR:JAKs,OSMR:JAKs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392263", "l": "AVP(20-28) binds AVPR2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.2.1", "l": "\"Unspecific peroxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804879", "l": "MDM2 ubiquitinates TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10598", "l": "ADP + H(+) + O-phospho-L-tyrosyl-[protein] => ATP + L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59364", "l": "1-octadecanoyl-2-(9,10-epoxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoserine + 9,10-epoxyoctadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56235", "l": "[(1->4)-alpha-D-galacturonosyl](n) + H2O <=> [(1->4)-alpha-D-galacturonosyl](n-2) + alpha-D-galacturonosyl-(1->4)-D-galacturonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48966", "l": "[thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O => 2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40485", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700171", "l": "Active ALK phosphorylates PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990521", "l": "m7G(5')pppN diphosphatase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807872", "l": "Active ARF recruits coatomer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14315", "l": "1-iodo-2-methoxybenzene + H(+) + S-adenosyl-L-homocysteine => 2-iodophenol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33719", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-hexacosanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-(hexacosanoyl)-sphinganine-1-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033802", "l": "isoliquiritigenin 2'-O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "76.412572999466406", "identifiers": [{"i": "GO:0008410", "l": "CoA-transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14846", "l": "L-aspartate 4-semialdehyde + pyruvate => (S)-2,3-dihydrodipicolinate + H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296127", "l": "Activation of voltage gated Potassium channels (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29764", "l": "ATP + H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) => ADP + H(+) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755572", "l": "Defective SRD5A3 does not reduce pPNOL to DCHOL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-196964", "l": "RFK:Mg2+ phosphorylates RIB (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41785", "l": "asialo-GM1a ganglioside (d18:1(4E)/18:0) + CMP-N-acetyl-beta-neuraminate => CMP + ganglioside GM1 (d18:1(4E)/18:0) + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0016419", "l": "S-malonyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35353", "l": "(2E)-octadecenoyl-CoA + H(+) + NADPH => NADP(+) + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34740", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine => H(+) + N-acyl-15-methylhexadecasphing-4-enine + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22223", "l": "ent-copalyl diphosphate <=> diphosphate + ent-kaur-16-ene"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050247", "l": "raucaffricine beta-glucosidase activity"}, {"i": "RHEA:14557", "l": "H2O + raucaffricine = D-glucose + vomilenine"}, {"i": "EC:3.2.1.125", "l": "\"Raucaffricine beta-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989772", "l": "Expression of GLIPR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031754", "l": "Edg-1 sphingosine 1-phosphate receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64650", "l": "(E)-feruloyl-CoA + H(+) + NADPH => (E)-coniferaldehyde + CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.21"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42365", "l": "2 a 2-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45522", "l": "(2R,3E)-phycocyanobilin + apo-[phycoerythrocyanin alpha-subunit] => [phycoerythrocyanin alpha-subunit]-Cys(84)-phycoviolobilin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63572", "l": "H2O + neurotensin-(1-8) = L-arginine + neurotensin-(1-7)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114558", "l": "Thrombin-activated PARs activate Gq (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877902", "l": "Activated AR binds RUNX2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707523", "l": "Hemes bind to BACH1:MAFK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446212", "l": "Flipping of the N-glycan precursor to inside the ER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349520", "l": "Re-acidification of acetylcholine transport vesicles (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0052827", "l": "inositol pentakisphosphate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13611", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17953", "l": "3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde"}, {"i": "EC:1.13.11.6", "l": "\"3-hydroxyanthranilate 3,4-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49732", "l": "H(+) + O2 + violaceinate = CO2 + H2O + violacein"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14243", "l": "3-acetylamino-4-hydroxybenzaldehyde + CoA + H(+) => 3-amino-4-hydroxybenzaldehyde + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391934", "l": "DP2 receptor can bind PGD2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31176", "l": "(2E)-2-methylpropenoyl-CoA + H2O => (S)-3-hydroxyisobutanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034897", "l": "4-(1-ethyl-1,4-dimethyl-pentyl)phenol monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54891", "l": "ATP + CoA + OPC-8 <=> AMP + diphosphate + OPC-8-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3899291", "l": "SUMOylation of EP300 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42537", "l": "uridine(65) in tRNA => pseudouridine(65) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676595", "l": "TRAFs bind RANK:RANKL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.25"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050035", "l": "L-sorbose oxidase activity"}, {"i": "KEGG.REACTION:R01695"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36569", "l": "GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADH => GDP-beta-L-colitose + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29735", "l": "butane-1-sulfonate + FMNH2 + O2 = butanal + FMN + 2 H(+) + H2O + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39261", "l": "(2E,13Z)-docosadienoyl-CoA + H2O => (3R)-hydroxy-(13Z)-docosenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37108", "l": "H2O + N(7)-methyl-GMP => N(7)-methylguanosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19886", "l": "(S)-reticuline + O2 => (S)-scoulerine + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64421", "l": "H(+)(out) + L-alanyl-L-proline(out) => H(+)(in) + L-alanyl-L-proline(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701507", "l": "PTPN6 dephosphorylates JAK3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382096", "l": "Formation of NR-NCOR Corepressor Complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19729", "l": "acetoacetate + H(+) = acetone + CO2"}, {"i": "EC:4.1.1.4", "l": "\"Acetoacetate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31597", "l": "(Z)-2-methylaminoacrylate + carbamate + H(+) => (Z)-2-methylureidoacrylate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102289", "l": "beta-amyrin 11-oxidase activity"}, {"i": "RHEA:31711", "l": "beta-amyrin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 11-oxo-beta-amyrin + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.152", "l": "\"Beta-amyrin 11-oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.9", "l": "\"Selenate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72671", "l": "eIF5B:GTP is hydrolyzed and released (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18998", "l": "CTP + H(+) + phosphocholine => CDP-choline + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050331", "l": "thiamine-diphosphate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25315", "l": "2-oxoglutarate + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate = L-2-acetamido-6-oxoheptanedioate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38449", "l": "4-O-(beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose => 4-O-(beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050632", "l": "propionyl-CoA C2-trimethyltridecanoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2529020", "l": "CK2 phosphorylates condensin I subunits (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801195", "l": "STEAP3 binds BNIP3L (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18670", "l": "adenosine + H2O => adenine + D-ribose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-912734", "l": "CBL:CRKL binds RAPGEF1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40953", "l": "acetate + L-2,4-diaminobutanoate => (2S)-2-acetamido-4-aminobutanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51899", "l": "H2O + N(1)-acetylspermine <=> acetate + spermine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41087", "l": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848250", "l": "ACBD6 binds LCFA-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11098", "l": "dihydroxyacetone phosphate + H(+) + NADPH => NADP(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371590", "l": "HSP70 binds to HSP40:nascent protein (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40100", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA => 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174157", "l": "Degradation of multiubiquitinated Cyclin B (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41745", "l": "3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol => a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52182", "l": "(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39644", "l": "(2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H(+) + NADPH => (18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59334", "l": "1'-hydroxytorulene + AH2 => 1'-hydroxy-gamma-carotene + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.1.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45465", "l": "2 [Fe(II)-cytochrome b5] + eicosanoyl-CoA + 2 H(+) + O2 => (5Z)-eicosenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11643", "l": "a (2R,3R)-flavan-3-ol + 2 NAD(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1471314", "l": "HNP1-3 bind CD4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211219", "l": "Translocation of caspase-3 to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10071", "l": "4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose <=> 4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "74.603620314006946", "identifiers": [{"i": "GO:0052745", "l": "inositol phosphate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36894", "l": "(9Z,12Z)-octadecadienoyl-CoA + AH2 + O2 <=> (9Z,12Z,15Z)-octadecatrienoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22873", "l": "2-oxoglutarate + L-prolyl-[collagen] + O2 => CO2 + succinate + trans-3-hydroxy-L-prolyl-[collagen]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111930", "l": "Adenylate cyclase produces cAMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033937", "l": "3-deoxy-2-octulosonidase activity"}, {"i": "MetaCyc:3.2.1.124-RXN"}, {"i": "EC:3.2.1.124", "l": "\"3-deoxy-2-octulosonidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396337", "l": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662608", "l": "MT2A binds cadmium (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32508", "l": "4-isopropenyl-7-methyloxepan-2-one + H2O => 6-hydroxy-3-isopropenylheptanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.9.-.-", "l": "\"Acting on phosphorus-nitrogen bonds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070282", "l": "pyridoxine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983147", "l": "Release of E3 from polyubiquitinated substrate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982775", "l": "Growth hormone receptor dimerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433542", "l": "Phosphorylation and activation of VAV1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3247836", "l": "Retromer recycles WLS to the Golgi (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31453", "l": "a cardiolipin + glycerol => 2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36151", "l": "(E)-cinnamyl alcohol + acetyl-CoA = (E)-cinnamyl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008577", "l": "IL37:IL18R1 binds SIGIRR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2067713", "l": "GP369 inhibits activation of amplified FGFR2 signaling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38598", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74711", "l": "Phosphorylation of IRS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36759", "l": "N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine = alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}, {"i": "EC:2.4.1.306", "l": "\"UDP-GalNAc:alpha-D-GalNAc-diphosphoundecaprenol alpha-1,3-N-acetylgalactosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11925", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose => globoside Gb3Cer (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008254", "l": "3'-nucleotidase activity"}, {"i": "RHEA:10144", "l": "a ribonucleoside 3'-phosphate + H2O = a ribonucleoside + phosphate"}, {"i": "EC:3.1.3.6", "l": "\"3'-nucleotidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29761", "l": "octanoate(out) => octanoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952128", "l": "RUNX3 binds TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46893", "l": "2-oxoglutarate + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate => 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37417", "l": "1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57395", "l": "(13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine <=> 3-O-acetyl-4'-O-demethylpapaveroxine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32229", "l": "(6S)-NADPHX => (6R)-NADPHX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44019", "l": "2,6,10,14-tetramethylpentadecanal + H2O + NAD(+) <=> 2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693356", "l": "CEMIP hydrolyses HA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381091", "l": "IRE1 dimer autophosphorylates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013004", "l": "RHOA binds effectors at the ER membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47534", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => chenodeoxycholate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40999", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54850", "l": "H2O + NADP(+) + propyl propanoate => H(+) + hexan-3-one + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944266", "l": "Association of procollagen type XI (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56337", "l": "ent-isokaurene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => ent-isokaurene-2beta,3beta-diol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60410", "l": "Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine] + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine => Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654125", "l": "Defective SLC39A4 does not transport Zn2+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44763", "l": "2-methoxy-6-all-trans-nonaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54869", "l": "(2E)-butenoyl-[ACP] + H(+) + NADH => butanoyl-[ACP] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50572", "l": "acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23035", "l": "2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24458", "l": "alpha-ribazole + phosphate => alpha-ribazole 5'-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2176445", "l": "SMURF2 binds SMAD2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140580", "l": "mitochondrion autophagosome adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683774", "l": "p-T68-CHEK2 dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48655", "l": "lipoxin B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-lipoxin B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34972", "l": "Fe(3+)(in) => Fe(3+)(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102044", "l": "3-chlorobenzoate-4,5-oxygenase activity"}, {"i": "MetaCyc:RXN-10421"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66134", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + H(+) + phosphate => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990655", "l": "4 iron, 3 sulfur cluster binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8856223", "l": "B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433395", "l": "Dimerization of sSCF (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174916", "l": "Formation of N-glucuronides (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61920", "l": "(2R,4S)-ketoconazole(in) + ATP + H2O = (2R,4S)-ketoconazole(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632887", "l": "TP53 binds the RRM2B gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0030291", "l": "protein serine/threonine kinase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218642", "l": "PTK2 autophosphorylates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63552", "l": "angiotensin-(1-7) + H2O = angiotensin-(1-5) + L-histidyl-L-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32676", "l": "alpha,alpha-trehalose + H2O => alpha-D-glucose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55609", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34554", "l": "ATP + cob(II)yrinate c monoamide + H2O + L-glutamine <=> ADP + cob(II)yrinate a,c diamide + H(+) + L-glutamate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58511", "l": "(3Z)-2-oxo-4-carboxy-3-hexenedioate + H2O <=> (2S)-2-hydroxy-4-oxobutane-1,2,4-tricarboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168297", "l": "Recognition of the Nuclear Localization Signal (NLS) by a Karyopherin Alpha Family Protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30368", "l": "adenosylcob(III)alamin 5'-phosphate + H2O => adenosylcob(III)alamin + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624158", "l": "Substrate:LAMP2a:HSP90 polymerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158300", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22262", "l": "H(+) + triacetate => H2O + triacetate lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188345", "l": "The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66129", "l": "2-oxobutanoate + L-phenylalanine => (2S)-2-aminobutanoate + 3-phenylpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45631", "l": "holo-[CmaD peptidyl-carrier protein] + L-alloisoleucyl-[CmaA peptidyl-carrier protein] <=> holo-[CmaA peptidyl-carrier protein] + L-alloisoleucyl-[CmaD peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25715", "l": "N-hydroxy-L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23559", "l": "D-alanine + L-glutamine <=> gamma-L-glutamyl-D-alanine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448744", "l": "IL20RA binds IL20RB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63915", "l": "6-azauridine + ATP <=> 6-azauridine 5'-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.60", "l": "\"Dactylysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62490", "l": "2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0003712", "l": "transcription coregulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54928", "l": "3-oxo-(9Z)-hexadecenoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57393", "l": "(13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine => 3-O-acetyl-4'-O-demethylpapaveroxine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647632", "l": "CASP3 cleaves GSDME (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66694", "l": "dTDP + H(+) + N(omega)-(alpha-L-rhamnosyl)-L-arginyl-[protein] => dTDP-beta-L-rhamnose + L-arginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246478", "l": "APOM binds retinoids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102371", "l": "betulin dehydrogenase activity"}, {"i": "MetaCyc:RXN-13498"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682603", "l": "nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140442", "l": "peroxide sensor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354173", "l": "Activation of Rap1 by cytosolic GEFs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014467", "l": "RHOG binds effectors at the ER membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40023", "l": "9alpha-copalyl diphosphate + H2O = diphosphate + syn-copalol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17187", "l": "GMP + 2 H(+) + NADPH => IMP + NADP(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6785213", "l": "LIPC dimer binds heparin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21672", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.100", "l": "\"Protein-S-isoprenylcysteine O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55425", "l": "(3S,6E)-nerolidol + O2 + reduced [NADPH--hemoprotein reductase] => (3E)-4,8-dimethylnona-1,3,7-triene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382053", "l": "Translocation of PDGF from ER to Golgi (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2168885", "l": "Haptoglobin binds Hemoglobin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24603", "l": "H2O + O2 + sulfite <=> H2O2 + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17685", "l": "H(+) + uracil 5-carboxylate = CO2 + uracil"}, {"i": "EC:4.1.1.66", "l": "\"Uracil-5-carboxylate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25637", "l": "H2O + NAD(+) + sulfoacetaldehyde = 2 H(+) + NADH + sulfoacetate"}, {"i": "EC:1.2.1.73", "l": "\"Sulfoacetaldehyde dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430180", "l": "NCK recruits WASP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008716", "l": "D-alanine-D-alanine ligase activity"}, {"i": "RHEA:11224", "l": "ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate"}, {"i": "EC:6.3.2.4", "l": "\"D-alanine--D-alanine ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75079", "l": "Formation of AT-AC C complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209823", "l": "Tyrosine is hydroxylated to dopa (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033509", "l": "USP9X binds Ub:PEX5L (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50818", "l": "5alpha-androstan-3,17-dione + NADP(+) => androst-4-ene-3,17-dione + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32937", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+) => a cardiolipin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21991", "l": "malonyl-CoA + pelargonidin 3-O-(6-O-[(E)-caffeoyl]-beta-D-glucoside) 5-O-beta-D-glucoside <=> 4'''-demalonylsalvianin + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111962", "l": "PDE4A,C,D hydrolyse cAMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62677", "l": "10-formyldihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide => 6-thio-IMP + 7,8-dihydrofolate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034824", "l": "citronellyl-CoA dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.184", "l": "\"Carbonyl reductase (NADPH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17758", "l": "H(+) + L-methionine => 3-(methylsulfanyl)propanamine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35050", "l": "adenylyl-molybdopterin + H(+) + molybdate <=> AMP + H2O + Mo-molybdopterin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1445149", "l": "14-3-3 binds p-5S,T642-AS160 (TBC1D4) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39340", "l": "(9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864595", "l": "TFAP2B homodimer binds YEATS4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12811", "l": "2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O => 4 catechol + 3 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48835", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46727", "l": "(2S)-2-methyltetradecanoyl-CoA <=> (2R)-2-methyltetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34773", "l": "a 3-oxosteroid + CO2 + NADPH => a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851988", "l": "BTN2A2 binds T cell surface (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.323", "l": "\"(+)-thujan-3-ol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191654", "l": "c-src associates with Cx43 in gap junctions (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19371", "l": "H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine => L-histidyl-[protein] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27425", "l": "(2E,6E)-farnesyl diphosphate = (E)-beta-farnesene + diphosphate"}, {"i": "EC:4.2.3.47", "l": "\"Beta-farnesene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353283", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31795", "l": "(+)-beta-caryophyllene + H2O = (+)-caryolan-1-ol"}, {"i": "EC:4.2.1.138", "l": "\"(+)-caryolan-1-ol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382054", "l": "PDGF binds to extracellular matrix proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.179", "l": "\"Methylxanthine N(3)-demethylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47522", "l": "isolithocholate + NADP(+) => 3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374251", "l": "DARC  is a non-specific receptor for many chemokines (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9626817", "l": "PKC phosphorylates NCF1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.123"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31735", "l": "3-oxocholan-24-oyl-CoA + NAD(+) = 3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3341294", "l": "Superoxide reduces cytochrome c (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42393", "l": "D-galactose + NAD(+) => D-galactono-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43326", "l": "1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416723", "l": "SEMA6A binds to PLXNA2 and PLXNA4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43864", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(in) = 1-hexadecanoyl-sn-glycero-3-phosphocholine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.126"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46514", "l": "2 [Fe(III)-cytochrome b5] + an N-[(2'R)-hydroxyacyl]sphinganine + H2O => 2 [Fe(II)-cytochrome b5] + an N-(1,2-saturated acyl)sphinganine + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786155", "l": "POLN binds ICL-DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21400", "l": "2-oxoglutarate + CoA + NADP(+) = CO2 + NADPH + succinyl-CoA"}, {"i": "EC:1.2.1.52", "l": "\"Oxoglutarate dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.29"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35251", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O = ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66536", "l": "A + cholest-4,6-dien-3-one + H2O = 25-hydroxycholest-4,6-dien-3-one + AH2"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015385", "l": "sodium:proton antiporter activity"}, {"i": "REACT:R-HSA-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59903", "l": "2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 <=> CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66828", "l": "2 ATP + 2 cob(II)alamin + 2 H2O + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390649", "l": "CHRM1,3,5 bind acetylcholine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5340226", "l": "CYGB dioxygenates NO (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981497", "l": "ST3GAL1-4 can add a sialic acid to the T antigen at the alpha 3 position (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3560794", "l": "Defective PAPSS2 does not transfer SO4(2-) group to ATP to form APS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265010", "l": "Cystine-bonded Proinsulin translocates from the endoplasmic reticulum to the Golgi (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632993", "l": "PTEN gene transcription is stimulated by TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32436", "l": "dihydrocarvone + H(+) + NADPH + O2 => 4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15982", "l": "H(+) + S-adenosyl-L-methionine => CO2 + S-adenosyl 3-(methylsulfanyl)propylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1170539", "l": "Prolactin receptor is internalized (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426489", "l": "RISC binds inexactly matching target RNAs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047853", "l": "difructose-anhydride synthase activity"}, {"i": "MetaCyc:DIFRUCTOSE-ANHYDRIDE-SYNTHASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0061135", "l": "endopeptidase regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672978", "l": "RAF phosphorylates MAP2K dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11677", "l": "D-ribose + H2O + NADP(+) => D-ribonate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66360", "l": "(7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H2O = (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507869", "l": "Aquaporins passively transport glycerol into cells (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12314", "l": "2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+) => dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38900", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450187", "l": "TAK1 is activated within the TAK1 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-917841", "l": "Acidification of Tf:TfR1 containing endosome (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690785", "l": "BAP1 binds Ub-HCFC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66704", "l": "H2O + mycophenolyl-CoA = CoA + H(+) + mycophenolate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705738", "l": "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193068", "l": "CYP17A1 17-hydroxylates PREG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52940", "l": "chenodeoxycholate + UDP-alpha-D-glucuronate = chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32673", "l": "ADP + H(+) + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate => ATP + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607746", "l": "PKC-delta is activated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55520", "l": "dimethylallyl diphosphate + 3 isopentenyl diphosphate = 3 diphosphate + nerylneryl diphosphate"}, {"i": "EC:2.5.1.142", "l": "\"Nerylneryl diphosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43353", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol(in) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2473184", "l": "Follistatin (FST) binds Activin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12011", "l": "[G-protein-coupled receptor] + ATP <=> [G-protein-coupled receptor]-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856808", "l": "Recruitment of AP-2 complex and clathrin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58220", "l": "L-lysyl-[protein] + NAD(+) = H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730892", "l": "Recruitment of VAV to p-SLP-76 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9611851", "l": "ADRB2 bind ADR,NAd (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-171106", "l": "LDLR:LDL complex => LDLR + LDL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684882", "l": "CHEK1 is recruited to resected DNA DSBs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102632", "l": "(S)-nandinine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987039", "l": "JAK1 binds IL20RA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31203", "l": "acetyl-CoA + hexanoyl-CoA = 3-oxooctanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19446", "l": "2,3-dihydroxyindole + O2 => anthranilate + CO2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683593", "l": "ATG7:ATG3:LC3 dissociates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38864", "l": "phosphate + sucrose 6(F)-phosphate => alpha-D-glucose 1-phosphate + beta-D-fructose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381435", "l": "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112434", "l": "Formation of DSIF complex  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102175", "l": "3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60335", "l": "L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28272", "l": "CoA + H(+) + N(8)-acetylspermidine => acetyl-CoA + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-593672", "l": "Myosin-X binds DCC/Neogenin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668904", "l": "Formation of the CTF18 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103045", "l": "methione N-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13544", "l": "H2O + tetrathionate <=> H(+) + sulfate + sulfur + thiosulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977301", "l": "Histidine is decarboxylated to histamine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33701", "l": "(4R)-hydroxyeicosasphinganine + 2 [Fe(III)-cytochrome b5] + H2O => 2 [Fe(II)-cytochrome b5] + C20 sphinganine + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193997", "l": "CYP11B1 oxidises 11DCORT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645428", "l": "ALPK1 binds ADP-heptose (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21715", "l": "L-threo-3-phenylserine <=> benzaldehyde + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50236", "l": "O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] = 17alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21438", "l": "[translation elongation factor 2]-phosphate + ADP + H(+) => [translation elongation factor 2] + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972949", "l": "POU5F1 (OCT4), SOX2, NANOG bind the EOMES promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29672", "l": "Ca(2+)(in) => Ca(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875183", "l": "CBL monoubiquitinates activated MET (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429497", "l": "SLP-76 stimulates PLC gamma 2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22377", "l": "uridine(38/39/40) in tRNA => pseudouridine(38/39/40) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19329", "l": "nuatigenin + UDP-alpha-D-glucose = H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP"}, {"i": "EC:2.4.1.192", "l": "\"Nuatigenin 3-beta-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14913", "l": "AMP + thymidine = adenosine + dTMP"}, {"i": "EC:2.7.1.114", "l": "\"AMP--thymidine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51901", "l": "H2O + N(1)-acetylspermidine => acetate + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202222", "l": "Phosphorylation of PKC theta (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25400", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate => (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12091", "l": "an N-acylsphing-4-enine + UDP-alpha-D-glucose <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-182988", "l": "Sprouty lures CBL away from EGFR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5362522", "l": "ALDHs oxidise atRAL to atRA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047830", "l": "D-octopine dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047452", "l": "protoaphin-aglucone dehydratase (cyclizing) activity"}, {"i": "RHEA:23876", "l": "protoaphin aglucone = H2O + xanthoaphin"}, {"i": "EC:4.2.1.73", "l": "\"Protoaphin-aglucone dehydratase (cyclizing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45691", "l": "N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(in) <=> N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17465", "l": "H2O + quercitrin = L-rhamnopyranose + quercetin"}, {"i": "EC:3.2.1.66", "l": "\"Quercitrinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60412", "l": "H2O + monoglucosyl-enterobactin = [N-(2,3-dihydroxybenzoyl)-L-seryl]2-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879770", "l": "Expression of DEC2 (BHLHE41, BHLHB3) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47485", "l": "deoxycholate + NAD(+) => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0032396", "l": "inhibitory MHC class I receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853444", "l": "AURKA phosphorylates PHLDA1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19318", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate => 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036131", "l": "prostaglandin D2 11-ketoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.48", "l": "\"Sucrose alpha-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14950", "l": "A + H2O + quinoline-4-carboxylate => 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008043", "l": "MAPK8 phosphorylation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54360", "l": "4-methyl-2-oxopentanoate + H(+) = 3-methylbutanal + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008694", "l": "IL37, IL37(?-218) translocates from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31092", "l": "acetyl-CoA + dodecanoyl-CoA => 3-oxotetradecanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56768", "l": "2 AH2 + all-trans-zeaxanthin + 2 O2 = 2 A + all-trans-adonixanthin + 3 H2O"}, {"i": "RHEA:56772", "l": "2 AH2 + all-trans-adonixanthin + 2 O2 = 2 A + all-trans-(3S,3'S)-astaxanthin + 3 H2O"}, {"i": "EC:1.14.99.64", "l": "\"Zeaxanthin 4-ketolase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102796", "l": "protocatechualdehyde:oxygen oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49358", "l": "2',2'-dihydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2'-hydroxy-2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196753", "l": "2xPPCS ligates PPanK with Cys (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624954", "l": "INPP5E translocates to the primary cilium (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46158", "l": "9,9',15-tri-cis-zeta-carotene + a plastoquinol => 15,9'-di-cis-phytofluene + a plastoquinone"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0031862", "l": "prostanoid receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28598", "l": "H2O + N-acetyl-L-lysine = acetate + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33861", "l": "H2O + versicolorin B => (2S-3S)-versiconal hemiacetal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940561", "l": "MMP7 cleaves OPTC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35704", "l": "1'-hydroxyversicolorone + H(+) + NADPH + O2 => (2S,3S)-versiconal hemiacetal acetate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30340", "l": "H(+) + L-tryptophan => CO2 + tryptamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102257", "l": "1-16:0-2-18:2-phosphatidylcholine sn-1 acylhydrolase activity"}, {"i": "MetaCyc:RXN-12430"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14478", "l": "a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49169", "l": "8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine => 8,12-diethyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021357", "l": "PRKCI phosphorylates ELF3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696960", "l": "USP49 deubiquitinates H2B (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20383", "l": "5alpha-androstan-3,17-dione + H(+) + NADH => 3alpha-hydroxy-5alpha-androstan-17-one + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21292", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)"}, {"i": "EC:2.7.1.153", "l": "\"Phosphatidylinositol-4,5-bisphosphate 3-kinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031418", "l": "L-ascorbic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007707", "l": "DLX5,(DLX6) binds RUNX2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389348", "l": "Activation of Rac1 by pVav1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39415", "l": "(2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH = (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45026", "l": "cholesta-5,7-dien-3beta-ol + 2 H2O + NADP(+) => cholesterol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20907", "l": "(2S)-2-hydroxypropyl-coenzyme M <=> (S)-1,2-epoxypropane + coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34227", "l": "5-nitrosalicylate + O2 = 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H(+) + nitrite"}, {"i": "EC:1.13.11.64", "l": "\"5-nitrosalicylate dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603437", "l": "Activated NTRK3 binds IRS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450348", "l": "Activated human JNKs migrate to nucleoplasm (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60882", "l": "a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+) => a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618331", "l": "HDAC6 deacetylates microtubules (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55389", "l": "(3R)-3-hydroxy-2,3-dihydrotabersonine + A => (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9631296", "l": "NR1H2,3 binds the FABP6 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28170", "l": "(2R)-2-hydroxy-2-methylbutanenitrile = butan-2-one + hydrogen cyanide"}, {"i": "EC:4.1.2.46", "l": "\"Aliphatic (R)-hydroxynitrile lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.24", "l": "\"Gelatinase A\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507870", "l": "Aquaporins passively transport water out of cells (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381612", "l": "GLP1R binds GLP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52348", "l": "(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110219", "l": "Cleavage of thymine by TDG glycosylase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015436", "l": "ABC-type capsular-polysaccharide transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22868", "l": "3-chloro-L-alanine + thioglycolate = chloride + H(+) + S-carboxymethyl-L-cysteine"}, {"i": "EC:4.5.1.5", "l": "\"S-carboxymethylcysteine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41047", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654514", "l": "KAL1 binds FGFR1c (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814831", "l": "TBC1D20 binds RAB1:GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61460", "l": "a cytidine in RNA + S-adenosyl-L-methionine = a 5-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48777", "l": "O2 + prostaglandin H2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxyprostaglandin H2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21651", "l": "H(+) + prephenate <=> 3-phenylpyruvate + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22827", "l": "2'-deoxyuridine + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + uracil"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944214", "l": "Association of procollagen type I (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2855047", "l": "Hydrolysis of internal thioester in C4b (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12507", "l": "NAD(+) + thiomorpholine-3-carboxylate <=> 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806957", "l": "MET receptor dimerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51493", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50924", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159771", "l": "Furin cleaves pro-protein C to protein C (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28939", "l": "H(+)(in) + xanthosine(in) = H(+)(out) + xanthosine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25521", "l": "an acyl-CoA + pseudotropine => CoA + H(+) + O-acylpseudotropine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203712", "l": "eNOS associates with Caveolin-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31822", "l": "(2E,6E)-farnesyl diphosphate <=> 5-epi-alpha-selinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41215", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202966", "l": "Caspase mediated cleavage of HIP-55 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38507", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990948", "l": "ubiquitin ligase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65531", "l": "hexan-1-ol + octanoyl-CoA <=> CoA + hexyl octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20732", "l": "[protein]-dithiol + [thioredoxin]-disulfide = [protein]-disulfide + [thioredoxin]-dithiol"}, {"i": "EC:1.8.4.16", "l": "\"Thioredoxin:protein disulfide reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51299", "l": "a quinone + H2O + L-methionyl-[protein] <=> a quinol + L-methionyl-(R)-S-oxide-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29208", "l": "a menaquinol(in) + dimethyl sulfoxide(out) => a menaquinone(in) + dimethyl sulfide(out) + H2O(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39601", "l": "(3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+) => 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692749", "l": "CDC14A,B bind MAPK6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030527", "l": "structural constituent of chromatin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15115", "l": "5alpha-cholestane-3beta,5,6beta-triol => 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605414", "l": "NOTCH4 binds SMAD3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10103", "l": "a sterol ester + H2O <=> a fatty acid + a sterol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50020", "l": "decanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + decanoyl-4'-phosphopantetheine + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20432", "l": "apigenin + S-adenosyl-L-methionine <=> acacetin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61529", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base => a diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54532", "l": "H2O + N-(4-oxoglutaryl)-L-cysteinylglycine = 2-oxoglutarate + L-cysteinylglycine"}, {"i": "EC:3.5.1.128", "l": "\"Deaminated glutathione amidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35542", "l": "cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2 <=> albonoursin + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8979071", "l": "KDM6B binds iron (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58514", "l": "1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20152", "l": "O2 + quinine + reduced [NADPH--hemoprotein reductase] <=> 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49888", "l": "(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2 = (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35727", "l": "dodecanoyl-CoA + sn-glycerol 3-phosphate = 1-dodecanoyl-sn-glycerol 3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985943", "l": "p-Y701-STAT1 dimerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1861788", "l": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58350", "l": "2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate => 2 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26485", "l": "adenosine(37) in tRNA + dimethylallyl diphosphate <=> diphosphate + N(6)-dimethylallyladenosine(37) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43111", "l": "2 [Fe(III)cytochrome c] + H2O + N2 <=> 2 [Fe(II)cytochrome c] + 2 H(+) + nitrous oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33888", "l": "(-)-secoisolariciresinol + 2 NAD(+) => (-)-matairesinol + 2 H(+) + 2 NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018700", "l": "2-chloro-N-isopropylacetanilide reductive dehalogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46179", "l": "2-methylpropanoate + ATP + CoA <=> 2-methylpropanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.4"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031708", "l": "endothelin B receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853762", "l": "RET dimerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050405", "l": "[acetyl-CoA carboxylase] kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295622", "l": "SPRY2 binds CBL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49407", "l": "beta-D-mannopyranosyl-(1->2)-D-mannopyranose + phosphate <=> alpha-D-mannose 1-phosphate + D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213210", "l": "Collagen IX is cross-linked to the surface of collagen type II fibrils (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952996", "l": "E2F7 forms homodimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17128", "l": "H2O + N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine <=> 2-oxoglutarate + N-(2-aminobutanoyl)glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396599", "l": "Recruitment of GRB2:SOS to p-5Y-LAT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018640", "l": "dibenzothiophene monooxygenase activity"}, {"i": "RHEA:49076", "l": "dibenzothiophene + FMNH2 + O2 = dibenzothiophene 5-oxide + FMN + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004015", "l": "adenosylmethionine-8-amino-7-oxononanoate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21181", "l": "1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol => D-glucose + indole-3-acetyl-1D-myo-inositol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983707", "l": "SYK autophosphorylates at the activated BCR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214953", "l": "Full-length SNK is cleaved by GD serine protease (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38679", "l": "ATP + H2O + sphinganine(in) = ADP + H(+) + phosphate + sphinganine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102368", "l": "beta-amyrin 30-monooxygenase activity"}, {"i": "MetaCyc:RXN-13489"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983374", "l": "p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030760", "l": "pyridine N-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0005501", "l": "retinoid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-453339", "l": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56196", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-alpha-D-galactose = H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209924", "l": "Dopa is decarboxylated to dopamine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58552", "l": "15alpha-stemmadenine intermediate II + H2O = (16R)-deshydroxymethyl-stemmadenine + formate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42869", "l": "norspermine + S-adenosyl 3-(methylsulfanyl)propylamine => caldopentamine + 2 H(+) + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18318", "l": "an L-alpha-amino acid => a D-alpha-amino acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19927", "l": "D-ribulose 5-phosphate + H(+) + NADH => D-ribitol 5-phosphate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21861", "l": "3'-phosphoadenylyl sulfate + quercetin 3,3'-bissulfate => adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3',7-trissulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13237", "l": "D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate"}, {"i": "EC:2.6.1.16", "l": "\"Glutamine--fructose-6-phosphate transaminase (isomerizing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1471322", "l": "Beta-defensins are secreted (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350400", "l": "PK binds to DSH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21664", "l": "4-nitrophenyl phosphate + H2O = 4-nitrophenol + H(+) + phosphate"}, {"i": "EC:3.1.3.41", "l": "\"4-nitrophenylphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956568", "l": "RUNX1 binds the core TAL1 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34054", "l": "2'''-acetyl-6'''-hydroxyneomycin C + H2O <=> 6'''-deamino-6'''-hydroxyneomycin C + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34647", "l": "S-adenosyl-L-methionine + squalene = 3-methyl-1,2-didehydro-2,3-dihydrosqualene + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912734", "l": "CBL:CRKL binds RAPGEF1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810076", "l": "DDO oxidizes D-Asp to OA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59754", "l": "CoA + H(+) + N(6)-tetradecanoyl-L-lysyl-[protein] => L-lysyl-[protein] + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9698408", "l": "PTPRJ dephosphorylates active FLT3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20667", "l": "1,5-anhydro-D-fructose + H(+) + NADPH => 1,5-anhydro-D-glucitol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032866", "l": "D-xylose:NADP reductase activity"}, {"i": "RHEA:27445", "l": "NADP(+) + xylitol = D-xylose + H(+) + NADPH"}, {"i": "MetaCyc:RXN-8773"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9021609", "l": "ESR-associated SRC autophosphorylates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2152276", "l": "Secretion of transmembrane collagens (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2176445", "l": "SMURF2 binds SMAD2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5591052", "l": "PROCR binds Protein C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45910", "l": "chloroeremomycin + dTDP + H(+) => chloroorienticin B + dTDP-beta-L-vancosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647680", "l": "CASP1 cleaves GSDMD (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32963", "l": "2-oxoglutaramate + H2O = 2-oxoglutarate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.29", "l": "\"Thymine-DNA glycosylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42545", "l": "uridine(32) in tRNA => pseudouridine(32) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853801", "l": "PSPN binds RET:GFRA4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983427", "l": "Expression of peptide bound class I MHC on cell surface (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848392", "l": "IL18BP binds IL18 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619803", "l": "p-S516-ARHGEF7 activates RAC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610735", "l": "NUMB binds ITCH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786110", "l": "JAK1 binds IL4R in IL13-bound IL13R type II (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174124", "l": "Dephosphorylation of phospho-Cdh1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691167", "l": "CUL1, SKP1, FBXL5 bind (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050147", "l": "nucleoside ribosyltransferase activity"}, {"i": "MetaCyc:NUCLEOSIDE-RIBOSYLTRANSFERASE-RXN"}, {"i": "EC:2.4.2.5", "l": "\"Nucleoside ribosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19785", "l": "2-oxoglutarate + dihydroclavaminate + O2 = clavaminate + CO2 + H2O + succinate"}, {"i": "EC:1.14.11.21", "l": "\"Clavaminate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19527", "l": "(1S,8aR)-delta-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060001", "l": "minus-end directed microfilament motor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004371", "l": "glycerone kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11001", "l": "an N-carbamoyl-D-amino acid + 2 H(+) + H2O => a D-alpha-amino acid + CO2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21976", "l": "[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite = [thioredoxin]-dithiol + adenosine 5'-phosphosulfate"}, {"i": "EC:1.8.4.10", "l": "\"Adenylyl-sulfate reductase (thioredoxin)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050442", "l": "3-propylmalate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16396", "l": "H2O + juvenile hormone II <=> H(+) + juvenile hormone II carboxylate + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193647", "l": "IRAK is activated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.31"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46183", "l": "2-methylbutanoate + ATP + CoA <=> 2-methylbutanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32861", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31793", "l": "(13S)-edaxadiene + diphosphate => H2O + tuberculosinyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20779", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose <=> myo-inositol + stachyose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42707", "l": "hercynine + L-cysteine + O2 <=> H2O + S-(hercyn-2-yl)-L-cysteine S-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247849", "l": "WLS dissociates from retromer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28201", "l": "(S)-1-phenylethanol + NAD(+) <=> acetophenone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5340214", "l": "CYGB binds O2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29622", "l": "alpha-maltotetraose + beta-maltose <=> alpha-maltopentaose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19345", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate = (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176517", "l": "SULTs transfer (SO4)2- group to PREG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18954", "l": "L-erythro-7,8-dihydrobiopterin + NADP(+) => H(+) + NADPH + sepiapterin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18827", "l": "[(1->6)-alpha-D-glucosyl](n+1) + D-fructose => [(1->6)-alpha-D-glucosyl](n) + sucrose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17850", "l": "(3R)-3-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37048", "l": "H(+)(out) + L-histidine(out) => H(+)(in) + L-histidine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55269", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate => (R)-glycerate + alpha-D-glucose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004300", "l": "enoyl-CoA hydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40603", "l": "1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381612", "l": "GLP1R binds GLP1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.56", "l": "\"7,8-dihydroneopterin 2',3'-cyclic phosphate phosphodiesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782820", "l": "USP17 deubiquitinates SUDS3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17058", "l": "a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP] => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102439", "l": "3',4',5'-trimethylmyricetin 7-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-13916"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61089", "l": "(S)-eriodictyol + 2-oxoglutarate + O2 => (2R,3R)-dihydroquercetin + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51175", "l": "cytidine(62) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(62) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928627", "l": "EPHB phosphorylates TIAM1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46107", "l": "21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> corticosterone + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35702", "l": "(S)-versiconol + NADP(+) <=> (2S-3S)-versiconal hemiacetal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047619", "l": "acylcarnitine hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54940", "l": "(3Z)-decenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(5Z)-dodecenoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41324", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64009", "l": "(4R)-hydroxysphinganine + hexadecanoyl-CoA => CoA + H(+) + N-hexadecanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47595", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) <=> CMP + ganglioside GP1c (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29307", "l": "FMNH2 + methanesulfonate + O2 = FMN + formaldehyde + 2 H(+) + H2O + sulfite"}, {"i": "EC:1.14.14.34", "l": "\"Methanesulfonate monooxygenase (FMNH(2))\""}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0070180", "l": "large ribosomal subunit rRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44157", "l": "1D-myo-inositol 5-phosphate + H2O => myo-inositol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41180", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69053", "l": "RFC binding displaces Pol Alpha (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15971", "l": "glutathione disulfide + H2O + methylarsonous acid => 2 glutathione + H(+) + methylarsonate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050636", "l": "vinorine synthase activity"}, {"i": "MetaCyc:2.3.1.160-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15929", "l": "2 H(+) + 2 H2O + methylenediurea = CO2 + N-(hydroxymethyl)urea + 2 NH4(+)"}, {"i": "EC:3.5.3.21", "l": "\"Methylenediurea deaminase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120325", "l": "NuRD complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11474", "l": "an L-alpha-amino acid + formaldehyde + H2O2 => an N-methyl-L-amino acid + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35002", "l": "ADP(in) + ATP(out) <=> ADP(out) + ATP(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008379", "l": "thioredoxin peroxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36957", "l": "(9Z)-pentadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + pentadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45149", "l": "3-(methylsulfanyl)acryloyl-CoA + H2O => 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68960", "l": "DNA polymerase epsilon binds at the origin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12169", "l": "allyl alcohol + NADP(+) => acrolein + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673789", "l": "Activated JNK phosphorylates c-JUN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50631", "l": "a 2-(omega-methylsulfanyl)alkylmalate <=> a 3-(omega-methylsulfanyl)alkylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10094", "l": "a 2'-deoxyribonucleoside + phosphate => a 2'-deoxyribonucleoside 3'-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046970", "l": "NAD-dependent histone deacetylase activity (H4-K16 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158278", "l": "factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21848", "l": "(E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide = (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide"}, {"i": "EC:5.2.1.6", "l": "\"Furylfuramide isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65407", "l": "butan-1-ol + hexanoyl-CoA <=> butyl hexanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46181", "l": "2-methylbutanoate + ATP + CoA => 2-methylbutanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50643", "l": "2-(2-methylsulfanyl)ethylmalate <=> 3-(2-methylsulfanyl)ethylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56571", "l": "globoside Gb4Cer + UDP-N-acetyl-alpha-D-galactosamine <=> globoside IV3GalNAc-Gb4Cer + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192624", "l": "cRNA Extension (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44484", "l": "3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25499", "l": "(2E)-geranyl diphosphate <=> (1S,5S)-beta-pinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42972", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a cardiolipin + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429992", "l": "PARN deadenylates mRNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800798", "l": "The PIDDosome binds CASP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640316", "l": "DeHA hydrolyses to threonate and oxalate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210273", "l": "Interaction of DAP12 and NKp44 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48115", "l": "N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187575", "l": "Ubiquitination of phospho-p27/p21 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11082", "l": "phosphate + thymidine => dTMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34893", "l": "selenite(out) => selenite(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48805", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4088130", "l": "PLK1 binds FOXM1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009007", "l": "site-specific DNA-methyltransferase (adenine-specific) activity"}, {"i": "RHEA:15197", "l": "a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.72", "l": "\"Site-specific DNA-methyltransferase (adenine-specific)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034005", "l": "germacrene-A synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61760", "l": "rebaudioside B + UDP-alpha-D-glucose = rebaudioside A + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451900", "l": "IL2RB binds JAK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-421835", "l": "trans-Golgi Network Vesicle Scission (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109858", "l": "MAP2K2 binds MAPK1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449077", "l": "Interleukin-16 is secreted (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877178", "l": "ATP binds to P2X7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53315", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052881", "l": "4-hydroxyphenylacetate 3-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29618", "l": "alpha-maltotriose + beta-maltose <=> alpha-maltotetraose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030266", "l": "quinate 3-dehydrogenase (NAD+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8948775", "l": "MKRN1 polyubiquitinates PTEN (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58377", "l": "decan-1-ol + NADP(+) => decanal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36432", "l": "a purine 2'-deoxy-D-ribonucleoside + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956050", "l": "NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009016", "l": "succinyldiaminopimelate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204871", "l": "Interaction of Tie2 and Grb2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0008796", "l": "bis(5'-nucleosyl)-tetraphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6800490", "l": "ATM phosphorylates PIDD1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189069", "l": "sucrose + H2O => glucose + fructose (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090704", "l": "nicotinate-O-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36016", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052811", "l": "1-phosphatidylinositol-3-phosphate 4-kinase activity"}, {"i": "REACT:R-HSA-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Homo sapiens)"}, {"i": "RHEA:63688", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15598", "l": "a Fe(III)-siderophore(out) + ATP + H2O => a Fe(III)-siderophore(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050204", "l": "oxalomalate lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018768", "l": "RHOU auto-activates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32845", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a triacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029273", "l": "PI3K binds to p-6Y-SYK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34990", "l": "(S)-lactate(in) <=> (S)-lactate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29086", "l": "(S)-malate + ubiquinone-8 <=> oxaloacetate + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39761", "l": "19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676599", "l": "sBAFF trimer binds BAFFR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429101", "l": "HMIT co-transports myo-inositol with a proton (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46580", "l": "O2 + reduced [NADPH--hemoprotein reductase] + vitamin D2 = 25-hydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15482", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O => (6S)-5,6,7,8-tetrahydrofolate + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156930", "l": "GTP-binding activates eEF2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140562", "l": "EGF-domain serine xylosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1974676", "l": "Beta defensin 103 activates TLR1:TLR2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373711", "l": "DCC interaction with Netrin-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389862", "l": "Conversion of glyoxylate to oxalate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196417", "l": "Reduction of desmosterol to cholesterol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21208", "l": "H2O + O-phospho-L-serine = L-serine + phosphate"}, {"i": "RHEA:24873", "l": "H2O + O-phospho-D-serine = D-serine + phosphate"}, {"i": "EC:3.1.3.3", "l": "\"Phosphoserine phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59087", "l": "2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose <=> 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51589", "l": "isopyridoxal + NAD(+) => 5-pyridoxolactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51260", "l": "4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] = (10bR,4aS)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "RHEA:51264", "l": "4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] = (10bS,4aR)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.19.50", "l": "\"Noroxomaritidine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006122", "l": "BDNF gene transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5140741", "l": "WNT5A binds FZD and ROR receptors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41534", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.35", "l": "\"sn-2 acyl-lipid omega-3 desaturase (ferredoxin)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909732", "l": "Phosphorylation of STAT2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52694", "l": "3-phenylpyruvate + H(+) + NADPH => 3-phenyllactate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483186", "l": "PC is converted to PS by PTDSS1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31249", "l": "prop-2-yn-1-ol + pyrroloquinoline quinone => H(+) + prop-2-ynal + pyrroloquinoline quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54325", "l": "a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 8 oxidized 2[4Fe-4S]-[ferredoxin] => a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3159259", "l": "MMAA:MUT binds AdoCbl (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56260", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP-alpha-D-galactose = 4 H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.88"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198813", "l": "GSTO dimers reduce DeHA to AscH- (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65864", "l": "5alpha-androst-1-ene-3,17-dione + A + H2O = 5alpha-androstan-1,3,17-trione + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51823", "l": "ATP(in) + CoA(in) + decanoate(out) + H(+)(out) <=> AMP(in) + decanoyl-CoA(in) + diphosphate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375133", "l": "Basigin binds Mannose-carrying cell recognition molecules (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29752", "l": "acetoacetate(in) => acetoacetate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10591", "l": "4 (R)-methylmalonyl-CoA + 12 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 8 NADPH <=> 4 CO2 + 4 CoA + 4 H2O + 8 NADP(+) + tetramethylated-mycocerosoyl-[mycocerosate synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948063", "l": "hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730872", "l": "Activation of Calcineurin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.99.-", "l": "\"With other acceptors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420206", "l": "Phosphorylation of SRC-1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38642", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59358", "l": "H(+) + lactobionate => H2O + lactobiono-1,5-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48680", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH"}, {"i": "EC:1.1.1.330", "l": "\"Very-long-chain 3-oxoacyl-CoA reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25298", "l": "acetaldehyde + H2O + NADP(+) = acetate + 2 H(+) + NADPH"}, {"i": "EC:1.2.1.4", "l": "\"Aldehyde dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865320", "l": "CBFB binds RUNX1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22172", "l": "beta-D-fructose 6-phosphate + UDP-alpha-D-glucose = H(+) + sucrose 6(F)-phosphate + UDP"}, {"i": "EC:2.4.1.14", "l": "\"Sucrose-phosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37413", "l": "aklaviketone + 2 H(+) + NADPH => aklavinone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015387", "l": "potassium:proton symporter activity"}, {"i": "RHEA:28490", "l": "H(+)(in) + K(+)(in) = H(+)(out) + K(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35423", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = an anthocyanidin 3,5-di-O-beta-D-glucoside + 2 H(+) + UDP"}, {"i": "EC:2.4.1.298", "l": "\"Anthocyanidin 3-O-glucoside 5-O-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801675", "l": "PLK2 phosphorylates NPM1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23867", "l": "4-CDP-2-C-methyl-D-erythritol 2-phosphate <=> 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74734", "l": "Re-integration of insulin receptor into plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13436", "l": "2'-deoxycytidine + H(+) + H2O <=> 2'-deoxyuridine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700114", "l": "NVP-TAE684-resistant ALK mutants don't bind NVP-TAE684 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29085", "l": "oxaloacetate + ubiquinol-8 => (S)-malate + ubiquinone-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65622", "l": "CoA + H(+) + N-hexadecanoylsphinga-(4E,8E)-dienine => hexadecanoyl-CoA + sphinga-(4E,8E)-dienine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033490", "l": "Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139909", "l": "Translocation of BMF to mitochondria (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174445", "l": "RPA binds to the Flap on the C-strand (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58299", "l": "25-substituted-cholesterol + beta-D-glucosyl-N-hexadecanoylsphing-4E-enine <=> 25-substituted-cholesteryl beta-D-glucoside + N-hexadecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-893597", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenic acid + H2O [mitochondrial] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58840", "l": "cholesterol sulfate + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-hydroxycholesterol 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51983", "l": "an L-N,N-dihydroxypolyhomomethionine + H(+) <=> an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1008200", "l": "NFE2 binds the beta globin locus control region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13747", "l": "microthecin => ascopyrone M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45499", "l": "[allophycocyanin alpha-subunit]-Cys(84)-phycocyanobilin <=> (2R,3E)-phycocyanobilin + apo-[allophycocyanin alpha-subunit]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9727349", "l": "XDH dehydrogenates xanthine to form urate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45514", "l": "(2R,3E)-phycocyanobilin + apo-[C-phycocyanin beta-subunit]-Cys(155) => [C-phycocyanin beta-subunit]-Cys(155)-phycocyanobilin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807008", "l": "PTPRJ dephosphorylates MET (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008684", "l": "TBK1 phosphorylation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55008", "l": "(1R,4S)-1-hydroxylimonen-2-one + NADPH + O2 = (3S)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50827", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 <=> 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25650", "l": "(2R,5R)-isopulegone + NADP(+) => (6R)-isopiperitenone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29621", "l": "alpha-maltopentaose + beta-D-glucose => alpha-maltotetraose + beta-maltose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48397", "l": "(3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine => 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43837", "l": "cholesterol + H(+) + NADPH + O2 => 26-hydroxycholesterol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42871", "l": "norspermine + S-adenosyl 3-(methylsulfanyl)propylamine <=> caldopentamine + 2 H(+) + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3095901", "l": "ABCC1 transports cytosolic Cbl to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357904", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451900", "l": "IL2RB binds JAK1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37306", "l": "ATP + glycyl-L-asparagine(out) + H2O <=> ADP + glycyl-L-asparagine(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40290", "l": "ATP + CoA + decanedioate <=> AMP + decanedioyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9674095", "l": "PDGFRs bind type II TKI (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875371", "l": "InlB binds MET (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635102", "l": "GPR161 is internalized (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46656", "l": "androst-4-ene-3,17-dione + H(+) + NADPH = 5beta-androstane-3,17-dione + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928627", "l": "EPHB phosphorylates TIAM1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51928", "l": "H2O + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD(+) = (S)-2,3-diaminopropanoate + 2-oxoglutarate + H(+) + NADH"}, {"i": "EC:1.5.1.51", "l": "\"N-((2S)-2-amino-2-carboxyethyl)-L-glutamate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24153", "l": "adenosine 5'-phosphosulfate + ATP => 3'-phosphoadenylyl sulfate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3858489", "l": "ppDVL binds DAAM1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49171", "l": "8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine <=> 8,12-diethyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63313", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => 15-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390674", "l": "ADRB1 bind ADR,NAd (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14341", "l": "2-oxoglutarate + glyoxylate + H(+) = 2-hydroxy-3-oxoadipate + CO2"}, {"i": "EC:2.2.1.5", "l": "\"2-hydroxy-3-oxoadipate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25267", "l": "2-phenylacetaldehyde + H2O2 + NH4(+) => 2-phenylethylamine + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975097", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29593", "l": "H(+) + NADPH + sulfoacetaldehyde => 2-hydroxyethane-1-sulfonate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389083", "l": "Autophosphorylation of PDGF alpha receptors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710480", "l": "Decitabine triphosphate incorporates into DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33087", "l": "cyclic dehypoxanthinylfutalosinate = 1,4-dihydroxy-6-naphthoate + chemical entity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56092", "l": "bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) = biliverdin IXalpha + reduced coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18301", "l": "ATP + NH4(+) + XMP = AMP + diphosphate + GMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17103", "l": "(R)-carnitine + a fatty acid + H(+) => H2O + O-acyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15811", "l": "(R)-linalool + diphosphate => (2E)-geranyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56379", "l": "3-bromo-4,5-dihydroxybenzoate + bromide + 3 H(+) + NADPH + O2 <=> 3,5-dibromobenzene-1,2-diol + CO2 + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57593", "l": "(S)-pinocembrin + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-2-hydroxypinocembrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1562603", "l": "BfrB stores iron (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389941", "l": "SHP-1 and SHP-2 bind pBTLA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21132", "l": "H2O + O2 + xanthine = H2O2 + urate"}, {"i": "EC:1.17.3.2", "l": "\"Xanthine oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36578", "l": "(9Z)-octadecenoyl-CoA + sphinganine <=> CoA + H(+) + N-(9Z-octadecenoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35808", "l": "2-dehydro-3-deoxy-D-arabinonate => 2,5-dioxopentanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9029690", "l": "Caspase-6 translocates to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008684", "l": "TBK1 phosphorylation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54053", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + tau-cadinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63625", "l": "hexadecanoyl-AMP + holo-[ACP] => AMP + H(+) + hexadecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50538", "l": "H2O + prostaglandin A2 => prostaglandin E2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170846", "l": "TGFBR2 recruits TGFBR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654625", "l": "Activated FGFR3 binds SHC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59591", "l": "ATP + beta-alanine + L-ornithine <=> ADP + beta-alanyl-L-ornithine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5432825", "l": "HMGB1 binds TLR4:LY96 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11731", "l": "cyclopentanol + NAD(+) <=> cyclopentanone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71303", "l": "RPE dimers isomerise RU5P to XY5P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14292", "l": "a dicarboxylate + ATP + CoA <=> AMP + diphosphate + omega-dicarboxyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61281", "l": "4-aminobutanoate + H2O + O2 => H2O2 + NH4(+) + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408542", "l": "GSSeSG is reduced to GSSeH and GSH by GSR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015107", "l": "chlorate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5615668", "l": "AKR1C3 reduces atRAL to atROL (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33625", "l": "AMP + diphosphate + dodecanoyl-CoA => ATP + CoA + dodecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5578965", "l": "TNRC6A binds AGO2:miRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21312", "l": "2,5-dihydroxybenzoate + H(+) = CO2 + hydroquinone"}, {"i": "EC:4.1.1.62", "l": "\"Gentisate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799246", "l": "CHEK1 phosphorylates TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32875", "l": "a 1-acyl-sn-glycerol + H2O = a fatty acid + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.61"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29840", "l": "L-idonate + NADP(+) => 2-dehydro-L-idonate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60337", "l": "N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28944", "l": "glycine betaine(in) => glycine betaine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604763", "l": "Autocatalytic activation of MMP7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32286", "l": "3-hydroxyanthranilate + O2 <=> H(+) + H2O + quinolinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781922", "l": "USP13 binds UFD1L:SKP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10651", "l": "2-hydroxycyclohexan-1-one + H(+) + NADPH + O2 <=> 6-hydroxyhexan-6-olide + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22658", "l": "CMP + H(+) + L-serine-phosphoethanolamine => CDP-ethanolamine + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22799", "l": "ATP + D-hamamelose <=> ADP + D-hamamelose 2'-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953339", "l": "DNPH1 hydrolyses dGMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27977", "l": "6-carboxy-5,6,7,8-tetrahydropterin + H(+) <=> 7-carboxy-7-deazaguanine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40742", "l": "(20S)-ginsenoside Rb2 + 2 H2O <=> (20S)-ginsenoside C-Y + 2 D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.11.1.-", "l": "\"Acting on carbon-phosphorus bonds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65218", "l": "3-oxododecanoate + CoA + H(+) => 3-oxododecanoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951486", "l": "CD46 binds C4b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044198", "l": "zf-TRAF domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168184", "l": "Activated TAK1 mediates phosphorylation of the IKK Complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938440", "l": "miR-17 binds RUNX1 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63295", "l": "N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1248) in human 18S rRNA + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182186", "l": "Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64895", "l": "holo-[ACP] + tetradecanoyl-AMP <=> AMP + H(+) + tetradecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23628", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)"}, {"i": "EC:2.4.1.65", "l": "\"3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5660666", "l": "CBP and p300 binds NF-kB complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165162", "l": "Phosphorylation of TSC2 by PKB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23944", "l": "(E)-coniferol + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-trans-coniferol + H(+) + UDP"}, {"i": "EC:2.4.1.111", "l": "\"Coniferyl-alcohol glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-937192", "l": "Cysteine from cystathionine and vice versa (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018569", "l": "hydroquinone 1,2-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63455", "l": "3-[(R)-glyceryl]-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin <=> GMP + H(+) + oxidized 3PG-factor420-0"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55206", "l": "5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+) => 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214860", "l": "CACT and DL/DIF dimer are phosphorylated in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46726", "l": "(2R)-2-methyltetradecanoyl-CoA => (2S)-2-methyltetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627056", "l": "Procaspase 9 forms dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17042", "l": "adenosine 5'-phosphosulfate + H2O => AMP + 2 H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15600", "l": "a Fe(III)-siderophore(out) + ATP + H2O <=> a Fe(III)-siderophore(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.18", "l": "\"Carboxypeptidase T\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25376", "l": "a 2-hydroxy-3-methyl fatty acyl-CoA => 2-methyl-branched fatty aldehyde + formyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32579", "l": "(2E)-geranyl diphosphate = (1R,5R)-beta-pinene + diphosphate"}, {"i": "EC:4.2.3.122", "l": "\"(+)-beta-pinene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56061", "l": "H(+) + hexadecanoate + hnu => CO2 + pentadecane"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34621", "l": "1-deoxy-11beta-hydroxypentalenate + CO2 + succinate => 1-deoxypentalenate + 2-oxoglutarate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51678", "l": "[protein]-dithiol + 2 AH2 + H(+) + sulfite => [protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047304", "l": "2-aminoethylphosphonate-pyruvate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15652", "l": "carbamate + 2 H(+) <=> CO2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616116", "l": "EGR2 and SOX10 bind the MAG gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428231", "l": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54997", "l": "3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47373", "l": "a quinone + D-glucose => a quinol + D-glucono-1,5-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9035484", "l": "CysS248-MPST:TXN2 dissociates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63591", "l": "prunetin + UDP-alpha-D-glucuronate <=> prunetin-4'-O-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13512", "l": "H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP <=> diphosphate + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814088", "l": "SYS1 binds AcM-ARFRP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25684", "l": "2 H(+) + H2O + N-hydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase] => L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.113", "l": "\"Pestivirus NS3 polyprotein peptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57798", "l": "4-methylcatechol + NAD(+) + nitrite => 4-nitrotoluene + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57228", "l": "GDP + glyoxal = N(2)-(1-hydroxy-2-oxoethyl)-GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66320", "l": "2',3'-cGAMP(out) = 2',3'-cGAMP(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944263", "l": "Association of procollagen type II (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60864", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936851", "l": "AHRR binds ARNT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49051", "l": "25-hydroxyvitamin D2 + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 1alpha,25-dihydroxyvitamin D2 + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33472", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-(4R)-4-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57822", "l": "[phosphate](n+1) + AMP => [phosphate](n) + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49230", "l": "diphosphate + geranylgeranyl-bacteriochlorophyllide a => (2E,6E,10E)-geranylgeranyl diphosphate + bacteriochlorophyllide a + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41962", "l": "ganglioside GA1 (d18:1(4E)) + H(+) + UDP => ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20739", "l": "acetyl-CoA + glycine <=> (2S)-2-amino-3-oxobutanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n6", "l": "\"Hexahomomethionine N-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30096", "l": "(S)-malate + a menaquinone => a menaquinol + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57911", "l": "ATP + L-glutamyl-tRNA(Gln) <=> 5-phosphooxy-L-glutamyl-tRNA(Gln) + ADP"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004614", "l": "phosphoglucomutase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173542", "l": "SMURF2 ubiquitinates SMAD2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36490", "l": "agmatine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + N(1)-aminopropylagmatine + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442405", "l": "hZIP5 mediates zinc uptake by cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.78", "l": "\"Arogenate dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193964", "l": "CYP21A2 21-hydroxylates PROG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2399913", "l": "atRAL binds to RBP2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047126", "l": "N5-(carboxyethyl)ornithine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24211", "l": "1,5-anhydro-D-mannitol + NADP(+) <=> 1,5-anhydro-D-fructose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28972", "l": "H(+)(in) + shikimate(in) => H(+)(out) + shikimate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956031", "l": "NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605717", "l": "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16910", "l": "2 [Fe(III)cytochrome c] + glycine + H2O => 2 [Fe(II)cytochrome c] + glyoxylate + 2 H(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21734", "l": "anthranilate + H(+) + L-glutamate + pyruvate => chorismate + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3780995", "l": "NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16013", "l": "ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)"}, {"i": "EC:6.1.1.14", "l": "\"Glycine--tRNA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38794", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0086007", "l": "voltage-gated calcium channel activity involved in cardiac muscle cell action potential"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045507", "l": "interleukin-25 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51768", "l": "2-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one + dimethylallyl diphosphate = 4-prenylphlormethylbutanophenone + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25776", "l": "scyllo-inosose = scyllo-inosine"}, {"i": "EC:5.3.99.11", "l": "\"2-keto-myo-inositol isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675198", "l": "Activated MAPKs phosphorylate BRAF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50941", "l": "L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe) => cyclo(L-phenylalanyl-L-leucyl) + H(+) + tRNA(Leu) + tRNA(Phe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674018", "l": "BRAP binds RAS:GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61402", "l": "ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysine => ATP + N(6)-(D-ribulosyl)-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213246", "l": "Disassociation of CLIP from MHC II (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008816", "l": "citryl-CoA lyase activity"}, {"i": "MetaCyc:CITRYLY-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19529", "l": "isovitexin + UDP-alpha-D-glucose = H(+) + isovitexin 2''-O-beta-D-glucoside + UDP"}, {"i": "EC:2.4.1.106", "l": "\"Isovitexin beta-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693347", "l": "CRYM reduces P2C to PPCA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40457", "l": "(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606312", "l": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1254291", "l": "ERBB4s80 binds STAT5A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18268", "l": "6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD(+) <=> 6-oxocyclohex-1-ene-1-carbonyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5660980", "l": "p-S276-RELA binds RELB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022065", "l": "DSPGs are secreted (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28868", "l": "H(+)(in) + lactose(in) => H(+)(out) + lactose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209815", "l": "Tyrosine is monoiodinated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944261", "l": "Association of procollagen type XIII (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.18"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070139", "l": "SUMO-specific endopeptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63084", "l": "chloride + FADH2 + ilicicolin B + O2 = FAD + H(+) + 2 H2O + ilicicolin A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60945", "l": "quercetin + S-adenosyl-L-methionine => H(+) + isorhamnetin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008271", "l": "CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14189", "l": "D-tryptophan + O2 = N-formyl-D-kynurenine"}, {"i": "EC:1.13.11.52", "l": "\"Indoleamine 2,3-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052874", "l": "FMN reductase (NADH) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57208", "l": "glyoxal + L-cysteinyl-[protein] = S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399712", "l": "Activation of Ca permeable AMPA receptors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31349", "l": "2-cis-(+)-abscisate + beta-D-glucose + H(+) => (+)-abscisic acid D-glucopyranosyl ester + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53808", "l": "cholestanol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55474", "l": "9beta-pimara-7,15-diene-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52445", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose => 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53687", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 <=> 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592387", "l": "Fibulin binds elastic fibres (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48362", "l": "a 2-hydroxy fatty acid + H2O => a 1,2-saturated fatty acid + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950684", "l": "Expression of Heterogeneous nuclear ribonucleoprotein D-like (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731149", "l": "Syndecan-4 binds ACTN1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187895", "l": "Engulfed CpG DNA binds to endosomal C-ter TLR9 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222723", "l": "Nitric oxide is oxidized to nitrate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45907", "l": "devancoaminyl-vancomycin + dTDP-beta-L-vancosamine <=> dTDP + epivancomycin + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33121", "l": "(+)-sativene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109807", "l": "GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623096", "l": "Delayed Early (DE) Gene Expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43775", "l": "guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13805", "l": "A + a 3-oxo-5alpha-steroid = a 3-oxo-Delta(4)-steroid + AH2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050026", "l": "L-glycol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691150", "l": "TFR2 dimer binds 2xholoTF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168887", "l": "Ferriheme is transferred from Albumin to Hemopexin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004458", "l": "D-lactate dehydrogenase (cytochrome) activity"}, {"i": "RHEA:13521", "l": "(R)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H(+) + pyruvate"}, {"i": "EC:1.1.2.4", "l": "\"D-lactate dehydrogenase (cytochrome)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9656893", "l": "OPN1MW binds 11cRAL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624948", "l": "KIF17 enters the cilium (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015233", "l": "pantothenate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47303", "l": "(9Z)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021952", "l": "RBFOX1 gene expression is inhibited by MECP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35876", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31042", "l": "dodecanoyl-CoA + FAD + H(+) <=> (2E)-dodecenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53963", "l": "4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + FMNH2 + O2 <=> 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + FMN + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32565", "l": "alpha-terpinene + diphosphate => (2E)-geranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093329", "l": "EFNBs bind SDCBP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51518", "l": "(R)-tembetarine + H(+) + S-adenosyl-L-homocysteine => (R)-reticuline + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692768", "l": "MAPKAPK5 phosphorylates KALRN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710101", "l": "CASP4, CASP5 cleave GSDMD (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944240", "l": "Association of procollagen type III (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873927", "l": "Release of STAT1 dimer from active receptor unit (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55449", "l": "a 3',5'-unsubstituted flavanone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => a 3',5'-dihydroxyflavanone + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090590", "l": "protein-N(PI)-phosphohistidine-D-glucosamine phosphotransferase system transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691004", "l": "XPC binds RAD23 and CETN2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62522", "l": "an N(4)-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9676160", "l": "AAMP binds NOD2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12251", "l": "NADP(+) + UDP-N-acetyl-alpha-D-muramate <=> H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3341294", "l": "Superoxide reduces cytochrome c (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429497", "l": "SLP-76 stimulates PLC gamma 2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43179", "l": "cytidine(2870) in 25S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(2870) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1454916", "l": "The ABCC family mediates organic anion transport (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21262", "l": "[thioredoxin]-dithiol + L-methionine (R)-S-oxide => [thioredoxin]-disulfide + H2O + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985343", "l": "RUNX2 binds SOX9 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64117", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53698", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686061", "l": "Nucleoprotein is ADP-ribosylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33499", "l": "H(+) + prephenate = 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2"}, {"i": "EC:4.1.1.100", "l": "\"Prephenate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53111", "l": "2-hydroxyestrone + S-adenosyl-L-methionine <=> 2-hydroxy-3-methoxy-estrone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48692", "l": "1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = H(+) + octanoate + octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15653", "l": "ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate + H(+)"}, {"i": "EC:2.7.1.105", "l": "\"6-phosphofructo-2-kinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0034325", "l": "O-decanoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607750", "l": "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "71.481339394433462", "identifiers": [{"i": "GO:0004540", "l": "ribonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008935", "l": "1,4-dihydroxy-2-naphthoyl-CoA synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21596", "l": "L-serine + NADP(+) = 2-aminomalonate semialdehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710106", "l": "ELANE cleaves GSDMD (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614460", "l": "Dimerization of procollagen type VI (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18096", "l": "5,6-dihydrouracil + NADP(+) <=> H(+) + NADPH + uracil"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050080", "l": "malonyl-CoA decarboxylase activity"}, {"i": "RHEA:18781", "l": "H(+) + malonyl-CoA = acetyl-CoA + CO2"}, {"i": "EC:4.1.1.9", "l": "\"Malonyl-CoA decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20384", "l": "3alpha-hydroxy-5alpha-androstan-17-one + NAD(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39128", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+) => 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61670", "l": "2-hydroxybenzoyl-CoA + AMP + diphosphate => ATP + CoA + salicylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27739", "l": "2'-deoxyguanosine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + guanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18474", "l": "1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25508", "l": "(2E)-geranyl diphosphate = (1S,5S)-sabinene + diphosphate"}, {"i": "EC:4.2.3.109", "l": "\"(-)-sabinene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9652264", "l": "ERBB2 binds TKIs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57160", "l": "2-oxoglutarate + L-arginyl-[ribosomal protein eS6] + O2 = (3R)-3-hydroxy-L-arginyl-[ribosomal protein eS6] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56893", "l": "H(+) + NADPH + UDP-4-dehydro-beta-L-rhamnose => NADP(+) + UDP-beta-L-rhamnose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65321", "l": "2-oxoglutarate + chrodrimanin E + O2 => chrodrimanin A + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981657", "l": "IL34 dimer binds PTPRZ1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939204", "l": "ESTG binds ESR1:chaperone complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203567", "l": "palmitoylation of eNOS (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61246", "l": "H2O2 + indole-3-pyruvate + NH4(+) => H2O + L-tryptophan + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264865", "l": "Caspase-mediated cleavage of Lamin A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9640195", "l": "RRAGA,B hydrolyzes GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55543", "l": "40 ATP + 40 H2O + N2 + 12 reduced [2Fe-2S]-[ferredoxin] <=> 40 ADP + 26 H(+) + 3 H2 + 2 NH4(+) + 12 oxidized [2Fe-2S]-[ferredoxin] + 40 phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044014", "l": "histone acetyltransferase activity (H2B-K5 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19503", "l": "4-aminobutanoate + urea => 4-guanidinobutanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38200", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791409", "l": "TP53 binds the CCNG1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17489", "l": "H(+) + NADH + O2 + phthalate = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)"}, {"i": "EC:1.14.12.7", "l": "\"Phthalate 4,5-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374909", "l": "Metabolism of Noradrenaline (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688797", "l": "ATXN3 family cleave Ub chains (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627350", "l": "SMAC (DIABLO) binds XIAP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41387", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112703", "l": "PTPN11 is phosphorylated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10408", "l": "4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18164", "l": "acetyl-CoA + tetradecanoyl-CoA <=> 3-oxohexadecanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12106", "l": "7,8-dihydrofolate + dTMP => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20986", "l": "an N-acylsphing-4-enine 1-phosphate + choline + H(+) => a sphingomyelin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15354", "l": "all-trans-violaxanthin + L-ascorbate => all-trans-antheraxanthin + H2O + L-dehydroascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848250", "l": "ACBD6 binds LCFA-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37858", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA <=> 1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693111", "l": "RHOF auto-activates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21574", "l": "CO + H(+) + N-acetylanthranilate => 3-hydroxy-2-methyl-1H-quinolin-4-one + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709842", "l": "MAVS binds TOMM70 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48287", "l": "globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose <=> globoside NOR1 (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66906", "l": "AH2 + cannabichromenate => A + cannabinerolate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110442", "l": "Activated DINR binds Chico (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2032775", "l": "YAP1 binds TEAD1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430190", "l": "p-SLP-76 binds NCK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16163", "l": "2 [Fe(II)-leghemoglobin] + H(+) + NAD(+) => 2 [Fe(III)-leghemoglobin] + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3132759", "l": "TCN1 binds Cbl (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39754", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008926", "l": "mannitol-1-phosphate 5-dehydrogenase activity"}, {"i": "MetaCyc:MANNPDEHYDROG-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018754", "l": "GDIs bind RHOH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14261", "l": "(E)-sinapoyl-CoA + D-glucono-1,5-lactone = 6-O-[(E)-sinapoyl]-D-glucono-1,5-lactone + CoA"}, {"i": "EC:2.3.1.132", "l": "\"Glucarolactone O-hydroxycinnamoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61309", "l": "(+)-(R)-germacrene A + O2 + reduced [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66160", "l": "hexanoyl-CoA + tyramine = CoA + H(+) + N-hexanoyltyramine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072548", "l": "dicoumaroyl monocaffeoyl spermidine meta-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174367", "l": "GCL ligates L-Glu to L-Cys (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692779", "l": "p-S182 MAPKAPK5 phosphorylates FOXO1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19714", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14505", "l": "2 glutathione + thiosulfate = glutathione disulfide + 2 H(+) + hydrogen sulfide + sulfite"}, {"i": "EC:2.8.1.3", "l": "\"Thiosulfate--thiol sulfurtransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23512", "l": "alpha,alpha-trehalose + phosphate = beta-D-glucose 1-phosphate + D-glucose"}, {"i": "EC:2.4.1.64", "l": "\"Alpha,alpha-trehalose phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102774", "l": "p-coumaroyltriacetic acid lactone synthase activity"}, {"i": "MetaCyc:RXN-7822"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36917", "l": "3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoA => (15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9699575", "l": "FOXO3-dependent CDKN1B gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49972", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24711", "l": "2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose => L-glutamate + UDP-beta-L-threo-pentopyranos-4-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23906", "l": "5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide] => an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928645", "l": "EPHB:NMDAR binds TIAM1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689111", "l": "PARK2 autoubiquitinates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47994", "l": "H(+)(out) + NADH + NADP(+) => H(+)(in) + NAD(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247844", "l": "WNT ligands traffic to the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685830", "l": "TUBB binds colchicine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30105", "l": "5-dehydro-D-gluconate + NAD(+) => 2,5-didehydro-D-gluconate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57922", "l": "H(+) + L-asparaginyl-tRNA(Asn) + phosphate => 4-phosphooxy-L-aspartyl-tRNA(Asn) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42369", "l": "dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.24", "l": "\"Mitogen-activated protein kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12939", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA => a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16098", "l": "acetylpyruvate + H2O => acetate + H(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47014", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine => [DsrC protein]-disulfide + H(+) + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8878654", "l": "ACP6 hydrolyses MYS-LPA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-990489", "l": "Kinesin-13 is a dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53746", "l": "glycine + H(+) + tRNA(Ala) => glycyl-tRNA(Ala) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20171", "l": "(11E)-tetradecenoyl-CoA + 2 H2O + NADP(+) => H(+) + NADPH + O2 + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30912", "l": "a sphingomyelin + H2O => a carboxylate + sphing-4-enine-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32394", "l": "(1R,2R,4R)-dihydrocarveol + NAD(+) <=> (1R,4R)-dihydrocarvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.34"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0052736", "l": "beta-glucanase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43857", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) => a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9017491", "l": "RHOJ GEFs activate RHOJ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848930", "l": "PTK6 translocates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9653514", "l": "USP17L2 deubiquitinates RCE1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018697", "l": "carbonyl sulfide nitrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419011", "l": "Transhomodimerization of Nectins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47591", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1c (d18:1(4E)) <=> CMP + ganglioside GQ1c (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59633", "l": "D-xylobiose + O2 => D-xylobiono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34261", "l": "(+)-3'-hydroxylarreatricin + A + H2O => (+)-larreatricin + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42211", "l": "an omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+) + NADPH + O2 <=> an omega-(methylsulfinyl)-alkyl-glucosinolate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25904", "l": "futalosine + H2O = dehypoxanthine futalosine + hypoxanthine"}, {"i": "EC:3.2.2.26", "l": "\"Futalosine hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22378", "l": "pseudouridine(38/39/40) in tRNA => uridine(38/39/40) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34767", "l": "5,10-methenyltetrahydrofolate + H2O = 5-formyltetrahydrofolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950175", "l": "Expression of Glutathione S-transferase omega-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10639", "l": "D-mannonate + NADP(+) <=> D-mannuronate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18782", "l": "H(+) + malonyl-CoA => acetyl-CoA + CO2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004582", "l": "dolichyl-phosphate beta-D-mannosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20681", "l": "cis-zeatin + UDP-alpha-D-glucose = H(+) + O-beta-D-glucosyl-cis-zeatin + UDP"}, {"i": "EC:2.4.1.215", "l": "\"Cis-zeatin O-beta-D-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936989", "l": "RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the THBS1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-442749", "l": "CaMKK autophosphorylates in the nucleus (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047910", "l": "galactose 1-dehydrogenase (NADP+) activity"}, {"i": "EC:1.1.1.120", "l": "\"Galactose 1-dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1799335", "l": "Synthesis of nascent polypeptide containing signal sequence (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247939", "l": "CysGly translocates from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165680", "l": "Formation of active mTORC1 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37790", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine <=> 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132047", "l": "Spontaneous hydrolysis of an internal thioester bond in complement factor C3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791109", "l": "GADD45A binds PCNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49165", "l": "a bacteriochlorophyllide c + H2O + S-adenosyl-L-methionine => 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide c + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56538", "l": "1,2,3-tri-(12R-hydroxy-9Z-octadecenoyl)-glycerol + CoA => (12R)-hydroxy-(9Z)-octadecenoyl-CoA + 1,2-di-(12R-hydroxy-9Z-octadecenoyl)-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48619", "l": "H2O + leukotriene D4 <=> glycine + leukotriene E4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49840", "l": "(-)-dehydrodiconiferyl acid + 2 a quinone + H2O = (-)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61344", "l": "H2O + L-serine + O2 = 3-hydroxypyruvate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52923", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56585", "l": "1,2-epoxypropane + H2O => propane-1,2-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8873929", "l": "Casein kinase II phosphorylates STARD10 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031809", "l": "H3 histamine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13872", "l": "NAD(+) + prephenate <=> 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10110", "l": "H(+) + NADPH + salutaridine => (7S)-salutaridinol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37335", "l": "5,6-dihydrothymine + H2O = 3-(carbamoylamino)-2-methylpropanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043808", "l": "lyso-ornithine lipid acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23995", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18598", "l": "H(+) + NAD(+) + 2 reduced [rubredoxin] => NADH + 2 oxidized [rubredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211224", "l": "Association of DFF40 with DFF45 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55896", "l": "chloride + FADH2 + L-tryptophan + O2 = 5-chloro-L-tryptophan + FAD + 2 H2O"}, {"i": "EC:1.14.19.58", "l": "\"Tryptophan 5-halogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54577", "l": "2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2 => an adenosine in tRNA + CO2 + formaldehyde + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11666", "l": "1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+) => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + CMP-N-acetyl-beta-neuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392064", "l": "G alpha (z) inhibits adenylate cyclase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41359", "l": "bacteriochlorophyll a + 3 NADP(+) <=> geranylgeranyl-bacteriochlorophyllide a + 3 H(+) + 3 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805426", "l": "CARD8 binds CASP9(1-416) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951486", "l": "CD46 binds C4b (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61099", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-eriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54599", "l": "2-oxoglutarate + hexadecanoyl-CoA + O2 <=> 2-hydroxyhexadecanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57328", "l": "acetyl-CoA + N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein] = CoA + H(+) + N-terminal N-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6813626", "l": "LEAP2 binds bacteria (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48344", "l": "an N-acyl-sphingoid base + UDP-alpha-D-galactose = a D-galactosylceramide + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25204", "l": "D-ribulose 5-phosphate + formaldehyde <=> D-arabino-hex-3-ulose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15514", "l": "ATP + keto-D-tagatose => ADP + H(+) + keto-D-tagatose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035274", "l": "diphenyl phthalate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.104", "l": "\"Mannan-binding lectin-associated serine protease-2\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31763", "l": "a 2-oxocarboxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid"}, {"i": "EC:2.6.1.88", "l": "\"Methionine transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1028820", "l": "Formation of VAF (virus-activated factor) complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71050", "l": "Trimerization of the FASL:FAS receptor complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30579", "l": "H2O + O-phospho-L-threonine = L-threonine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55385", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate => 6 diphosphate + tetra-trans,hexa-cis-undecaprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627369", "l": "SEPT4 binds XIAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18710", "l": "A + H2O + taurine => AH2 + NH4(+) + sulfoacetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2214324", "l": "Collagen type VII dimerization (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25614", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => terpentedienyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050283", "l": "serine-sulfate ammonia-lyase activity"}, {"i": "RHEA:15605", "l": "H2O + L-serine O-sulfate = H(+) + NH4(+) + pyruvate + sulfate"}, {"i": "EC:4.3.1.10", "l": "\"Serine-sulfate ammonia-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669911", "l": "Phosphorylation of juxtamembrane domain KIT mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57481", "l": "2-hydroxydodecanoate + H2O2 => 2,3-dihydroxydodecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37360", "l": "D-glucosamine(out) + N(pros)-phospho-L-histidyl-[protein] => D-glucosamine 6-phosphate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52551", "l": "L-threonate + NAD(+) <=> 2-dehydro-L-erythronate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45141", "l": "2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O => CO2 + L-glutamyl-[protein] + O2 + phylloquinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19998", "l": "H2O + phosphoenolpyruvate => phosphate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12366", "l": "a quinol + beta-nicotinamide D-riboside => 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23698", "l": "D-glucuronate + H(+) + H2O => myo-inositol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37495", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57751", "l": "2 (S)-methylmalonyl-CoA + 10 H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 3 malonyl-CoA + 5 NADPH <=> C32-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35401", "l": "beta-D-glucose + cyanidin 3-O-[6-O-(6-O-4-hydroxycinnamoyl-beta-D-glucosyl)-2-O-beta-D-xylosyl-beta-D-galactoside] + H(+) => 1-O-(trans-4-coumaroyl)-beta-D-glucose + cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) betaine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47809", "l": "epothilone D + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => epothilone B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29959", "l": "alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-galactose = alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944263", "l": "Association of procollagen type II (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102686", "l": "UDP-glucose:trans-zeatin 9-N-glucosyltransferase"}, {"i": "MetaCyc:RXN-4722"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296304", "l": "GPR31 is a receptor for 12(S)-HETE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10118", "l": "CO2 + D-ribulose 5-phosphate + NADPH => 6-phospho-D-gluconate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2203480", "l": "COLEC11 binds ligands (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55270", "l": "(R)-glycerate + alpha-D-glucose 1-phosphate => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983150", "l": "Proteasomal cleavage of substrate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53506", "l": "5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65778", "l": "3-(3-chloro-4-methylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => chlorotoluron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58837", "l": "24-methylenecycloartanol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34486", "l": "4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA <=> 4-hydroxybenzalacetone + 2 CO2 + 2 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65267", "l": "3-hydroxypentacecilide A + A <=> AH2 + chrodrimanin C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16685", "l": "di-trans,poly-cis-dolichol + hexadecanoyl-CoA = CoA + dolichyl hexadecanoate"}, {"i": "EC:2.3.1.123", "l": "\"Dolichol O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12027", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + choline <=> D-glucose + O-sinapoylcholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31797", "l": "(+)-caryolan-1-ol => (+)-beta-caryophyllene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34274", "l": "2-nitroimidazole + H2O <=> 1,3-dihydro-2H-imidazol-2-one + H(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66319", "l": "an inositol phosphomannosyl-alpha-1->6-inositol-1-phospho-N-acyl-4R-hydroxysphinganine + H2O <=> alpha-D-mannosyl-di-(inositol-1-phosphate) + an N-acyl-(4R)-4-hydroxysphinganine + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015345", "l": "ferric enterobactin:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54615", "l": "2-oxoglutarate + 3-methylbutanoyl-CoA + O2 <=> 2-hydroxy-3-methylbutanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008762", "l": "UDP-N-acetylmuramate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31818", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-beta-caryophyllene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047959", "l": "glycine dehydrogenase (cytochrome) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61474", "l": "an N-hexadecanoyl-sphingoid base + CoA + H(+) => a sphingoid base + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29311", "l": "FMNH2 + O2 + sulfoacetate = FMN + glyoxylate + 2 H(+) + H2O + sulfite"}]}
{"type": "biolink:MolecularActivity", "ic": "55.878866893815221", "identifiers": [{"i": "GO:0008168", "l": "methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18721", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate = diphosphate + ent-13-epi-manoyl oxide"}, {"i": "EC:4.2.3.186", "l": "\"Ent-13-epi-manoyl oxide synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14138", "l": "3'-phosphoadenylyl sulfate + beta-D-galactosyl-(1<->1)-sphing-4-enine => 6-O-sulfo-beta-D-galactosyl-(1<->1)-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12549", "l": "2-cis,4-trans-xanthoxin + NAD(+) => 2-cis-(+)-abscisic aldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43645", "l": "H(+) + malonyl-[ACP] + tetradecanoyl-CoA => 3-oxohexadecanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52695", "l": "3-phenyllactate + NADP(+) <=> 3-phenylpyruvate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0016795", "l": "phosphoric triester hydrolase activity"}, {"i": "EC:3.1.8.-", "l": "\"Phosphoric triester hydrolases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176973", "l": "Association of MCM8 with ORC:origin complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.-", "l": "\"Acting on acid anhydrides; catalyzing transmembrane movement of substances\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.12"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29407", "l": "2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + NADPH + O2 = 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26221", "l": "abieta-7,13-dien-18-ol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = abieta-7,13-dien-18-oate + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.145", "l": "\"Abieta-7,13-dien-18-ol hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416516", "l": "GRK2 sequesters activated Gq (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964274", "l": "G alpha (12) binds BTK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448678", "l": "CTSG cleaves CASP1(1-404) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18398", "l": "ATP + L-glutamate + tRNA(Glx) => AMP + diphosphate + L-glutamyl-tRNA(Glx)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34469", "l": "diphosphate + valerena-4,7(11)-diene => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2855047", "l": "Hydrolysis of internal thioester in C4b (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58821", "l": "H(+) + malonate + Na(+)(in) => acetate + CO2 + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57312", "l": "H2O + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine = cytidine 5'-diphosphoramidate + H(+) + L-glutamate"}, {"i": "EC:3.5.1.129", "l": "\"N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-170159", "l": "Translocation of Cdc25 to the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49130", "l": "5'-deoxyadenosine + A + 2 H(+) + L-methionine + N-acetyl-L-phosphinothricin + S-adenosyl-L-homocysteine => AH2 + N-acetyl-demethyl-L-phosphinothricin + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426566", "l": "Interaction of DAP12 and CLM7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202137", "l": "AKT1 binds eNOS complex via HSP90 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15915", "l": "ADP + thiamine diphosphate => ATP + thiamine phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44188", "l": "(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018652", "l": "toluene-sulfonate methyl-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176452", "l": "Degradation of ubiquitinated SMAD2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.98.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29170", "l": "H2O + pyruvate + ubiquinone-8 <=> acetate + CO2 + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444171", "l": "Receptor FFAR2 binds carboxylates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58109", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] => acetate + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622367", "l": "CEBPA mRNA is translated to yield CEBPA protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195275", "l": "Phosphorylation of APC component of the destruction complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.7.1"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080059", "l": "flavonol 3-O-arabinosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66107", "l": "3-(4-hydroxyphenyl)pyruvate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30856", "l": "dammarenediol-II => (S)-2,3-epoxysqualene + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102604", "l": "naringenin,NADPH:oxygen oxidoreductase activity"}, {"i": "RHEA:31723", "l": "liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] = (2R,3S)-2,4',7-trihydroxyisoflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "RHEA:35487", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2,3-dihydrogenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.87", "l": "\"2-hydroxyisoflavanone synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938121", "l": "SERPINB13 binds CTSK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50814", "l": "1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22159", "l": "GDP + H2O <=> GMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32553", "l": "(S)-alpha-terpineol + diphosphate => (2E)-geranyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15904", "l": "(2R)-2-phosphoglycerate <=> (2R)-3-phosphoglycerate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55880", "l": "apo-[aequorin]--coelenterazine + O2 = [aequorin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018791", "l": "2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162194", "l": "COQ9 dimer:COQ7:Fe2+ hydroxylates DMQ10H2 to DeMQ10H2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34921", "l": "thiamine(out) => thiamine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193997", "l": "CYP11B1 oxidises 11DCORT (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180627", "l": "Interaction of Vpr with importin alpha (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35138", "l": "L-alanyl-L-glutamate(out) <=> L-alanyl-L-glutamate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607721", "l": "Activation of NIK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11959", "l": "cholesteryl 3-beta-D-glucoside + H2O <=> cholesterol + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58502", "l": "glyoxylate + H2O + NAD(+) + trimethylamine => glycine betaine + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50729", "l": "(Z)-(4-hydroxyphenyl)acetaldehyde oxime => 4-hydroxyphenylacetonitrile + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10499", "l": "L-arginyl-[myelin basic protein] + S-adenosyl-L-methionine <=> H(+) + N(omega)-methyl-L-arginyl-[myelin basic protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047593", "l": "6-acetylglucose deacetylase activity"}, {"i": "MetaCyc:6-ACETYLGLUCOSE-DEACETYLASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74707", "l": "Binding of IRS to insulin receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848751", "l": "PTK6 binds AKT1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1264832", "l": "JAK1 binds IL7R (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008068", "l": "extracellularly glutamate-gated chloride channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392749", "l": "Transport of L1 into endosomes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9005995", "l": "MECP2 binds the SIN3A co-repressor complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52343", "l": "a long-chain fatty acyl-AMP + holo-[mycocerosate synthase] <=> AMP + H(+) + long-chain fatty acyl-[mycocerosate synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46431", "l": "4beta-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-4beta,26-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26245", "l": "geranylgeranyl diphosphate = diphosphate + fusicocca-2,10(14)-diene"}, {"i": "EC:4.2.3.43", "l": "\"Fusicocca-2,10(14)-diene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730856", "l": "Autophosphorylation of PAK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30301", "l": "a nucleobase within DNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + a methylated nucleobase within DNA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12558", "l": "6-phospho-D-gluconate + H(+) => 6-phospho-D-glucono-1,5-lactone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53593", "l": "1-tetradecanoyl-sn-glycerol 3-phosphate + H2O => 1-tetradecanoyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20048", "l": "3-oxopropanoate + H2O + NAD(+) <=> 2 H(+) + malonate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707645", "l": "HMOX1 gene produces HMOX1 dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047815", "l": "D-arabinonolactonase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427570", "l": "Group 3 - Selective Cl- transport (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14023", "l": "20-hydroxyecdysone + A + H2O => AH2 + ecdysone + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29645", "l": "alpha-D-glucose + alpha-maltohexaose => alpha-maltoheptaose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14305", "l": "ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)"}, {"i": "EC:6.1.1.15", "l": "\"Proline--tRNA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801087", "l": "TP53 binds the RABGGTA gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-421833", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10775", "l": "6-phospho-beta-D-glucosyl-(1->4)-D-glucose + H2O <=> D-glucose + D-glucose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018503", "l": "ESR1:ESTG bind the EBAG9 5' region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020274", "l": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8939203", "l": "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706312", "l": "Active FLT3 binds to LCK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63910", "l": "ADP + H(+) + phosphate + pravastatin(out) => ATP + H2O + pravastatin(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964773", "l": "OXGR1 binds 2OG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40843", "l": "FAD + H(+) + octadecanoyl-CoA = (2E)-octadecenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655824", "l": "Expression of Farnesyl Diphosphate Synthase (FDPS) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32014", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-T-muurolol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211193", "l": "Homodimerization  of DFF40 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21747", "l": "S-adenosyl-L-methionine <=> 1-aminocyclopropane-1-carboxylate + H(+) + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173709", "l": "C7 binds C5b:C6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27897", "l": "3'-CMP + H2O <=> cytidine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32031", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + gamma-curcumene"}, {"i": "EC:4.2.3.94", "l": "\"Gamma-curcumene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030562", "l": "rRNA 2'-O-ribose methylation guide activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-167415", "l": "G-protein alpha subunit is inactivated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56005", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35314", "l": "3-hydroxyisoheptadecanoyl-CoA + NADP(+) <=> 3-oxoisoheptadecanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013361", "l": "NEXT3 is cleaved to produce NICD3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615626", "l": "PMP22 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64173", "l": "L-altrarate => galactarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-877187", "l": "P2X7 mediates loss of intracellular K+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106226", "l": "peptide 2-hydroxyisobutyryltransferase activity"}, {"i": "RHEA:24180", "l": "2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176417", "l": "SMAD7:NEDD4L complex translocates to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66813", "l": "5-aminopentanoate + acetyl-CoA + 20 H(+) + 8 malonyl-CoA + 13 NADPH => 8 CO2 + 9 CoA + 7 H2O + 13 NADP(+) + wortmanamide B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21936", "l": "carbamoyl phosphate + putrescine = H(+) + N-carbamoylputrescine + phosphate"}, {"i": "EC:2.1.3.6", "l": "\"Putrescine carbamoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26261", "l": "H2O + isopimara-7,15-dienal + NADP(+) = 2 H(+) + isopimarate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38036", "l": "(2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate => (4Z)-2-oxohept-4-enedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661425", "l": "BIL:ALB dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34485", "l": "4-hydroxybenzalacetone + 2 CO2 + 2 CoA => 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.2.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4332235", "l": "CBL binds TGFBR2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19186", "l": "glyoxylate + H2O + propanoyl-CoA => 2-hydroxyglutarate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186785", "l": "PDGF-AA clevage by Furin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669878", "l": "Sunitinib-resistant KIT mutants do not bind sunitinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388560", "l": "EDNRA,EDNRB bind EDNs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877879", "l": "RUNX1 and FOXP3 bind the RSPO3 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140806", "l": "SERPINC1 binds SERPINC1 activators (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39238", "l": "(3R)-hydroxytriacontanoyl-CoA <=> (2E)-triacontenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49417", "l": "ADP + alpha-D-ribose 1-phosphate => alpha-D-ribose 1,5-bisphosphate + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781897", "l": "USP11 deubiquitinates NFKBIA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625520", "l": "MSTN gene expression is stimulated by FOXO1 and p-2S-SMAD2/3:SMAD4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45343", "l": "[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O <=> (9Z)-hexadecenoate + [Wnt protein]-L-serine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25023", "l": "CDP + FMN + H(+) => CTP + riboflavin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12428", "l": "2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH = benzene-1,2,4-triol + NAD(+)"}, {"i": "EC:1.6.5.7", "l": "\"2-hydroxy-1,4-benzoquinone reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16275", "l": "a sphingomyelin + CMP + H(+) => an N-acylsphing-4-enine + CDP-choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40370", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP <=> 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58349", "l": "2 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 O2 => 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6795460", "l": "SGK1 phosphorylates MDM2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1028817", "l": "CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64559", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one <=> 8-epi-ilicicolin H"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391939", "l": "TP receptor can bind thromboxane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26195", "l": "(S)-malyl-CoA + ADP + phosphate => (S)-malate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446322", "l": "PARVA associates with Paxillin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33226", "l": "2-oxobutanoate + CoA + NAD(+) <=> CO2 + NADH + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362437", "l": "C-terminal Hh fragments are bound by lectins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34276", "l": "2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine => 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50602", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] => acetyl-CoA + N-terminal L-seryl-[histone H2A]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75244", "l": "FASL binds FAS Receptor (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20315", "l": "1D-myo-inositol hexakisphosphate + ADP + H(+) => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57523", "l": "15,16-epoxydolabrene + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxy-15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008962", "l": "phosphatidylglycerophosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-377644", "l": "Release of CSK from SRC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50904", "l": "L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47822", "l": "9-ribosyl-trans-zeatin 5'-triphosphate + H2O + NADP(+) => H(+) + N(6)-(dimethylallyl)adenosine 5'-triphosphate + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.25"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10563", "l": "4-hydroxy-1-pyrroline-2-carboxylate + H(+) + H2O <=> 2,5-dioxopentanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798748", "l": "Exocytosis of secretory granule lumen proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61279", "l": "H2O + L-ornithine + O2 <=> 5-amino-2-oxopentanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32573", "l": "2-methylisoborneol + diphosphate => (E)-2-methylgeranyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36865", "l": "(9Z,12Z)-octadecadienoyl-CoA + A + 2 H2O => (9Z)-octadecenoyl-CoA + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047577", "l": "4-hydroxybutyrate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64404", "l": "carnosine(out) + H(+)(out) = carnosine(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62716", "l": "stemphyloxin I = stemphyloxin II"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53979", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6795460", "l": "SGK1 phosphorylates MDM2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372449", "l": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-844447", "l": "NLRP1 senses MDP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199093", "l": "CXADR binds to AMICA1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51847", "l": "(9Z)-hexadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (9Z)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25277", "l": "3',5'-cyclic AMP + H2O = AMP + H(+)"}, {"i": "EC:3.1.4.53", "l": "\"3',5'-cyclic-AMP phosphodiesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606602", "l": "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112604", "l": "Phosphorylated STATs are released (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944684", "l": "miR-205 microRNA binds PTEN mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001849", "l": "complement component C1q complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10991", "l": "H2O + nitrous oxide <=> 2 e(-) + 2 H(+) + 2 nitric oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391942", "l": "IP receptor can bind prostacyclin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63794", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate => C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164423", "l": "PhosphoChREBP (Thr 666)  is exported to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349404", "l": "CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193702", "l": "Part of the ICD migrates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25229", "l": "L-arabinitol + NADP(+) = H(+) + L-arabinose + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033856", "l": "pyridoxine 5'-phosphate synthase activity"}, {"i": "MetaCyc:PDXJ-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61773", "l": "rebaudioside E + UDP-alpha-D-glucose => H(+) + rebaudioside D + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47577", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) => CMP + ganglioside GD1c (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53208", "l": "daidzein + O2 + reduced [NADPH--hemoprotein reductase] = 2'-hydroxydaidzein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938199", "l": "RUNX1:CBFB binds the MYL9 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749197", "l": "ORC1 binds to H4K20me2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16904", "l": "acetyl-CoA + L-2,4-diaminobutanoate <=> (2S)-4-acetamido-2-aminobutanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0038064", "l": "collagen receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36399", "l": "5alpha-cholest-8-en-3beta-ol + NADP(+) = 5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55359", "l": "11-cis-retinol <=> 13-cis-retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19565", "l": "(2E)-geranyl diphosphate + H2O = diphosphate + sabinene hydrate"}, {"i": "EC:4.2.3.11", "l": "\"Sabinene-hydrate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64839", "l": "2-phenylethanol + acetyl-CoA <=> CoA + phenethyl acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19407", "l": "(3S)-citryl-CoA + acetate => acetyl-CoA + citrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56996", "l": "aldehydo-D-apiose = apulose"}, {"i": "EC:5.3.1.36", "l": "\"D-apiose isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32656", "l": "a carboxylate + eugenol + NADP(+) => a coniferyl ester + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482892", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45316", "l": "H(+) + NADPH + prostaglandin D2 = 11beta-prostaglandin F2 + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42647", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[malonate decarboxylase ACP] <=> diphosphate + holo-[malonate decarboxylase ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49298", "l": "L-histidyl-[protein] + L-sorbose 1-phosphate(in) => keto-L-sorbose(out) + N(pros)-phospho-L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11028", "l": "ATP + D-mannose = ADP + D-mannose 6-phosphate + H(+)"}, {"i": "EC:2.7.1.7", "l": "\"Mannokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399939", "l": "Autophosphorylation of PAK (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106026", "l": "Gly-tRNA(Ala) hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416562", "l": "p190RhoGAP binds Plexin-B1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369114", "l": "PRLR binds SHP2 (PTPN11) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102136", "l": "3-epi-6-deoxocathasterone C-23 hydroxylase activity"}, {"i": "RHEA:27321", "l": "3-epi-6-deoxocathasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6-deoxotyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "RHEA:27325", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 3-dehydro-6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.147", "l": "\"3-epi-6-deoxocathasterone 23-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188002", "l": "Rab5-mediated recruitment of class III PI3K to TLR9 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31494", "l": "soyasaponin III + UDP-beta-L-rhamnose <=> H(+) + soyasaponin I + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41961", "l": "ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose => ganglioside GA1 (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14156", "l": "17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP-N-acetyl-alpha-D-glucosamine <=> 17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucosiduronate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632939", "l": "TP53 binds the PTEN promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669250", "l": "PAK1 phosphorylates FLNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9687638", "l": "MLKL binds IP4, IP5 and IP6  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36484", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA => (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40974", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49136", "l": "H(+) + L-methionyl-[protein] + NADPH + O2 = H2O + L-methionyl-S-oxide-[protein] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807872", "l": "Active ARF recruits coatomer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019154", "l": "glycolate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70241", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21959", "l": "UDP-alpha-D-glucose + vitexin <=> H(+) + UDP + vitexin 2''-O-beta-D-glucoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20818", "l": "3-oxoglycyrrhetinate + H(+) + NADPH => 3alpha-hydroxyglycyrrhetinate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928604", "l": "SFKs phosphorylate VAV2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.4", "l": "\"Trypsin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63468", "l": "all-trans-octaprenol + ATP = ADP + all-trans-octaprenyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112266", "l": "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357831", "l": "CYLD is phosphorylated by IKK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-877187", "l": "P2X7 mediates loss of intracellular K+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31142", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) <=> 3-hydroxy-3-methyl-2-oxobutanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850786", "l": "SPINK6 binds KLK12 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23899", "l": "5-dehydro-4-deoxy-D-glucuronate <=> 3-deoxy-D-glycero-2,5-hexodiulosonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696947", "l": "USP47 deubiquitinates POLB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32121", "l": "GDP + H(+) + validoxylamine A 7'-phosphate => GDP-valienol + validamine 7-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63020", "l": "(9Z,12Z)-octadecadienamide + H2O = (9Z,12Z)-octadecadienoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34373", "l": "(indol-3-yl)acetate + NH4(+) => H2O + indole-3-acetamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44702", "l": "a (2E)-enoyl-CoA + FADH2 => a 2,3-saturated acyl-CoA + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371527", "l": "HSF1 trimer translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008893", "l": "guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity"}, {"i": "EC:3.1.7.2", "l": "\"Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38912", "l": "avenacoside B + H2O => 26-desgluco-avenacoside B + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56408", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z-octadecaenoyl)-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390673", "l": "CHRM2,4 bind acetylcholine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11038", "l": "ADP + H(+) + phosphate + quaternary ammonium(in) => ATP + H2O + quaternary ammonium(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33111", "l": "(2E,6E)-farnesyl diphosphate = beta-copaene + diphosphate"}, {"i": "EC:4.2.3.127", "l": "\"Beta-copaene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42010", "l": "5alpha-pregnane-3,20-dione + H(+) + NADH => 5alpha-pregnan-20beta-ol-3-one + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730886", "l": "Phosphorylation of SHC by SYK kinase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209295", "l": "Phosphorylated DL/DIF dimer transports from the cytosol to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015545", "l": "bicyclomycin transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433374", "l": "Processing of SCF isoform 1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662603", "l": "MT1B binds zinc (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34556", "l": "a (2S)-2-hydroxycarboxylate + NAD(+) => a 2-oxocarboxylate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863718", "l": "AGFG1 binds VAMP7 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30756", "l": "ATP + carbamate => ADP + carbamoyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9609921", "l": "SGTA binds Tail-anchored protein (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49876", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399939", "l": "Autophosphorylation of PAK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674022", "l": "BRAP autoubiquitinates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44417", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665034", "l": "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40082", "l": "docosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52510", "l": "13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102754", "l": "chlorophyllide-b:phytyl-diphosphate phytyltransferase activity"}, {"i": "MetaCyc:RXN-7674"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39200", "l": "(3R)-hydroxytetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66775", "l": "ATP + H2O + uroporphyrin I(in) <=> ADP + H(+) + phosphate + uroporphyrin I(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140090", "l": "membrane curvature sensor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30438", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + glycyl-tRNA(Gly) <=> beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + tRNA(Gly)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018695", "l": "4-cresol dehydrogenase (hydroxylating) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247840", "l": "WLS binds WNT ligands in the Golgi (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39585", "l": "(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+) => (2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203979", "l": "Coat Assembly (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2559439", "l": "CD14:LPS binds CR3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9010872", "l": "SLIT2 binds Dystroglycan (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48993", "l": "1,3,7-trimethylurate + H(+) + NADH + O2 => 1,3,7-trimethyl-5-hydroxyisourate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483219", "l": "PC is exchanged with PI by PITPNB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690873", "l": "ACO1 binds 4Fe-4S (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043682", "l": "P-type divalent copper transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28200", "l": "acetophenone + H(+) + NADH => (S)-1-phenylethanol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29914", "l": "ATP + H2O + N-acetyl-D-glucosamine(in) <=> ADP + H(+) + N-acetyl-D-glucosamine(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24359", "l": "a 1-acyl-sn-glycero-3-phosphocholine <=> a 2-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047700", "l": "beta-glucoside kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34437", "l": "4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine => 4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449058", "l": "Interleukin-1 family are secreted (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12500", "l": "NADP(+) + thiomorpholine-3-carboxylate = 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417820", "l": "P2Y9 receptor can bind to LPA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029454", "l": "Autophosphorylation of PAK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13546", "l": "(6E,10E)-geranyllinalool + O2 + reduced [NADPH--hemoprotein reductase] => (3E,7E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36491", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA = (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56825", "l": "AH2 + cyclooctat-9-ene-5,7-diol + O2 => A + cyclooctatin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25795", "l": "ATP + Cu(+)(in) + H2O <=> ADP + Cu(+)(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168897", "l": "LRP1 (CD91) binds Hemopexin:heme (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26145", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) => 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070006", "l": "metalloaminopeptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684836", "l": "CLEC1B dimer binds PDPN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865605", "l": "BRWD1 binds SMARCA4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166038", "l": "GPI-bound CD14 binds LPS (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2424476", "l": "Activation of RAC1 by VAV2/3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74059", "l": "PDE6 hydrolyses cGMP to GMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44949", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + H2O => 1-O-alkyl-2-acyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "51.778088465429171", "identifiers": [{"i": "GO:0016705", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23579", "l": "(R)-N-methylcoclaurine + (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] <=> berbamunine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264834", "l": "Endocytosis and degradation of apoA-I (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31587", "l": "FMNH2 + NADH + O2 + uracil = (Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085347", "l": "PIAS1 SUMOylates SAFB with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54929", "l": "3-oxo-(9Z)-hexadecenoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72631", "l": "Formation of the cap-binding eIF4F complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36612", "l": "(3S,5S)-carbapenam-3-caboxylate + 2-oxoglutarate + O2 => (5R)-carbapenem-3-carboxylate + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15976", "l": "3'-phosphoadenylyl sulfate + estrone <=> adenosine 3',5'-bisphosphate + estrone 3-sulfate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014449", "l": "RHOG binds effectors at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066782", "l": "Translocation of DPA to the ER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955748", "l": "RUNX1 binds the SOCS3 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31704", "l": "2 H(+) + O2 + pentalenene + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60569", "l": "N-acetyl-L-tryptophan => N-acetyl-D-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.-.-", "l": "\"Acting on ester bonds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54421", "l": "3',3'-c-di-AMP + H2O => 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730843", "l": "Phosphorylation of LAT by p-SYK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.3", "l": "\"Omega-amidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12041", "l": "(S)-3-(imidazol-5-yl)lactate + NADP(+) => 3-(imidazol-5-yl)pyruvate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683925", "l": "ULK1 is dephosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65678", "l": "a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontadienoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontadienoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042012", "l": "interleukin-16 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31995", "l": "(2E,6E)-farnesyl diphosphate = 7-epi-sesquithujene + diphosphate"}, {"i": "EC:4.2.3.101", "l": "\"7-epi-sesquithujene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43402", "l": "H(+) + N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP => N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52924", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36360", "l": "2 a plastoquinone + 2 H2O + 4 hnu => 2 a plastoquinol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22003", "l": "D-xylose + NADP(+) <=> D-xylono-1,5-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48663", "l": "8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24410", "l": "inosine + NH4(+) => adenosine + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450422", "l": "KSRP recruits RNA degradation activities (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21605", "l": "styrene oxide => 2-phenylacetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29436", "l": "enterobactin(in) + H(+)(out) => enterobactin(out) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607023", "l": "factor IXa associates with cell membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380930", "l": "Phosphorylated AMPK binds AMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21687", "l": "(R)-beta-alanopine + H2O + NAD(+) <=> beta-alanine + H(+) + NADH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.191"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25288", "l": "4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950183", "l": "IL12B binds IL23A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203979", "l": "Coat Assembly (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45273", "l": "12-phosphooxy-(9Z)-octadecenoate + H2O => 12-hydroxy-(9Z)-octadecenoate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428273", "l": "SPHK1 phosphorylates SPG to S1P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42086", "l": "9-cis-retinoate + 2 H(+) + NADH => 9-cis-retinal + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538904", "l": "Phosphorylated PER binds to CLK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22588", "l": "4-aminobutanal = 1-pyrroline + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44306", "l": "a 1-acyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + dodecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.12"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.-", "l": "\"With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39425", "l": "(2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59072", "l": "AH2 + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + A + cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.308", "l": "\"Cytidylyl-2-hydroxyethylphosphonate methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27620", "l": "di-trans,undeca-cis-tetradecaprenyl diphosphate + 11 diphosphate => (2Z,6E)-farnesyl diphosphate + 11 isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65469", "l": "1-propanol + acetyl-CoA => CoA + propyl acetate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015364", "l": "dicarboxylate:inorganic phosphate antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211919", "l": "CYP4F8 19-hydroxylates PGH2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64326", "l": "cholesteryl (11Z)-octadecenoate + CoA => (11Z)-octadecenoyl-CoA + cholesterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38996", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O => a 1-acyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35835", "l": "2'-dehydrokanamycin A + H(+) + NADPH = kanamycin A + NADP(+)"}, {"i": "EC:1.1.1.355", "l": "\"2'-dehydrokanamycin reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44720", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25501", "l": "(2E)-geranyl diphosphate => diphosphate + terpinolene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32537", "l": "4-hydroxy-2-oxohexanoate => (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3238694", "l": "PORCN palmitoleoylates N-glycosyl WNTs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2106614", "l": "Duplex miRNA is loaded into Argonaute (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0016297", "l": "acyl-[acyl-carrier-protein] hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58859", "l": "(6E)-8-hydroxygeraniol + NAD(+) <=> (6E)-8-oxogeraniol + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391158", "l": "SIRP alpha binds CD47 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48455", "l": "ganglioside GA2 (d18:1(4E)) + H2O <=> a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51306", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate => (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.53", "l": "\"Beta-N-acetylgalactosaminidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64666", "l": "a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+) => a long-chain fatty acyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42133", "l": "isonocardicin C => nocardicin C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.45"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30290", "l": "15-cis-phytoene + 2 a plastoquinone <=> 9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25576", "l": "3 O2 + protoporphyrinogen IX = 3 H2O2 + protoporphyrin IX"}, {"i": "EC:1.3.3.4", "l": "\"Protoporphyrinogen oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25822", "l": "4-aminobutanal + H2O2 + propane-1,3-diamine => H2O + O2 + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2314686", "l": "Aspirin acetylates PTGS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "81.20444558259193", "identifiers": [{"i": "GO:0015020", "l": "glucuronosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2730835", "l": "Autophosphorylation of PKC-theta (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65509", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + H2O + O2 => H2O2 + NH4(+) + pre-mycofactocin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605717", "l": "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199299", "l": "AKT phosphorylates FOXO transcription factors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38554", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoate + O2 <=> (R)-2-hydroxyhexadecanoate + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.39"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43538", "l": "4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate => 2 D-glyceraldehyde 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54570", "l": "a pseudouridine in rRNA => a uridine in rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52025", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 => 18S-resolvin E2 + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191654", "l": "c-src associates with Cx43 in gap junctions (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51118", "l": "H(+) + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine => guanosine(6) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23353", "l": "2-oxoglutarate + 4-aminobutanoate => L-glutamate + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050393", "l": "vinylacetyl-CoA delta-isomerase activity"}, {"i": "RHEA:10572", "l": "vinylacetyl-CoA = (2E)-butenoyl-CoA"}, {"i": "EC:5.3.3.3", "l": "\"Vinylacetyl-CoA Delta-isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016275", "l": "[cytochrome c]-arginine N-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43874", "l": "3-oxochol-4-en-22-oyl-CoA + AMP + diphosphate => 3-oxochol-4-en-22-oate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299476", "l": "MPP cleaves targeting peptide (presequence) of inner membrane precursors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58666", "l": "2-oxoglutarate + a quinol => (S)-2-hydroxyglutarate + a quinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57879", "l": "uridine(54) in tRNA <=> pseudouridine(54) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982778", "l": "Growth hormone binds the growth hormone receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32008", "l": "9alpha-copalyl diphosphate => diphosphate + isopimara-8(14),15-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55057", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798528", "l": "S100A8:S100A9 binds Mn2+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63059", "l": "acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine <=> 5-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24374", "l": "H(+) + N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine => H2O + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32342", "l": "(+)-thujan-3-ol + NADP(+) <=> (+)-thujan-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607734", "l": "PKC-delta translocates to plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917696", "l": "Cargo Sequestration (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390673", "l": "CHRM2,4 bind acetylcholine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33426", "l": "N(pros)-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out) <=> diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64279", "l": "chrysophanol-9-anthrone + O2 <=> chrysophanol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21513", "l": "3,6-anhydro-L-galactonate => 2-dehydro-3-deoxy-L-galactonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21276", "l": "D-arabinitol + NADP(+) = D-xylulose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66280", "l": "solanidine + UDP-alpha-D-glucose = H(+) + solanidine 3-O-beta-D-glucopyranoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8934465", "l": "SHC1 binds PTPN12 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954056", "l": "E2F6 binds TFDP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416530", "l": "FFAR1:FFAR1 ligands activates Gq (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57468", "l": "(E)-ferulate + UDP-alpha-D-glucose = 1-O-[(E)-feruloyl]-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48314", "l": "2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+) => benzoyl-CoA + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-984689", "l": "Kinesin-7 is a dimer (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47571", "l": "ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose <=> ganglioside GD1b (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44135", "l": "2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> 2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990585", "l": "hydroxyproline O-arabinosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6795667", "l": "MDM2 translocates to the cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22324", "l": "H2O + leukotriene A4 = leukotriene B4"}, {"i": "EC:3.3.2.6", "l": "\"Leukotriene-A(4) hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668605", "l": "RAC2:GTP binds NOX2 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71050", "l": "Trimerization of the FASL:FAS receptor complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618479", "l": "ABCA1 mRNA is translated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58934", "l": "5 CO2 + 6 CoA + demethylluteothin + 3 H2O + 4 NADP(+) => 4 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 8 H(+) + malonyl-CoA + 4 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798528", "l": "S100A8:S100A9 binds Mn2+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51540", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] = (S)-corytuberine + 2 H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.19.51", "l": "\"(S)-corytuberine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60144", "l": "ATP + L-glutamate + L-glutamyl-[protein] = ADP + H(+) + L-gamma-glutamyl-L-glutamyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21774", "l": "NH4(+) + uridine(6666) in apoB mRNA => cytidine(6666) in apoB mRNA + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64065", "l": "(1R,2R)-pseudoephedrine + NAD(+) => (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696958", "l": "USP44 deubiquitinates CDC20 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52435", "l": "(R)-2,3-diaminopropanoate + H(+) + H2O <=> 2 NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.198", "l": "\"Alpha-mannan endo-1,2-alpha-mannanase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2514831", "l": "Fibrillin-1 degradation by MMP14 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805546", "l": "Keratin type I binds keratin type II (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17132", "l": "ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide <=> 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69005", "l": "Cdc6 protein is phosphorylated by CDK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11766", "l": "methylamine + urea => H2O + methylguanidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11011", "l": "a 5'-end triphospho-(purine-ribonucleoside) in mRNA + H2O <=> a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36792", "l": "H2O + N(omega)-hydroxy-L-arginine => hydroxyurea + L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2197691", "l": "WIP binds WASP,N-WASP, activating them (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22095", "l": "(3Z)-phycoerythrobilin + oxidized 2[4Fe-4S]-[ferredoxin] <=> 15,16-dihydrobiliverdin + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9656947", "l": "OGG1beta translocates to mitochondria (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950057", "l": "IL12RB1 binds TYK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482772", "l": "Release of platelet cytosolic components (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30796", "l": "2-oxoadipate + CoA + NAD(+) => CO2 + glutaryl-CoA + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038132", "l": "neuregulin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54610", "l": "a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-lysyl-[protein] => a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026464", "l": "BDNF-bound NTRK2 dimers trans-autophosphorylate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51358", "l": "(9Z)-octadecenoate + L-glutamine => H2O + N-(9Z-octadecenoyl)-L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38381", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49593", "l": "2-hydroxyisobutanoyl-CoA => (3S)-3-hydroxybutanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65507", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + H2O <=> 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + [mycofactocin precursor peptide]-C-terminal glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-976801", "l": "Complement factor I complex formation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32536", "l": "(2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O => 4-hydroxy-2-oxohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3878123", "l": "Initiation of SAHF formation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000701", "l": "purine-specific mismatch base pair DNA N-glycosylase activity"}, {"i": "EC:3.2.2.31", "l": "\"Adenine glycosylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73757", "l": "Binding of RRN3 to RNA Polymerase I (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42271", "l": "2-methylpropanoyl-CoA + H(+) + malonyl-[ACP] <=> 4-methyl-3-oxopentanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.81"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24801", "l": "2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31432", "l": "(2E,6E)-farnesyl diphosphate => (-)-beta-santalene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875443", "l": "USP8 deubiquitinates LRIG1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34716", "l": "15-methylhexadecasphing-4-enine + ATP => 15-methylhexadecasphing-4-enine 1-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23216", "l": "benzoyl-CoA + H(+) + NADPH + O2 = 3-hydroxybenzoyl-CoA + H2O + NADP(+)"}, {"i": "EC:1.14.13.58", "l": "\"Benzoyl-CoA 3-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848124", "l": "PTK6 phosphorylates STAT3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12571", "l": "4-nitrophenol + H(+) + NADH + O2 <=> 4-nitrocatechol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52108", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3204318", "l": "cob(II)alamin binds to MTRR:MTR (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782381", "l": "PUS1 isoform 2 transforms uridine residues to pseudouridine in the anticodon stems of tRNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419490", "l": "Binding of ATP to P2X receptors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50362", "l": "benzoyl cyanide + H2O2 => (R)-mandelonitrile + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-708349", "l": "Activated NOD2 oligomerizes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4086083", "l": "SUMOylation of ING2 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11989", "l": "1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine => 1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12711", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685606", "l": "CLEC2D binds KLRB1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45404", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate = 1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709317", "l": "CO binds to free ferrohemoglobin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174551", "l": "Formation of alternative pathway C5 convertase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13414", "l": "ADP + thymidine => AMP + dTMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983700", "l": "SYK binds the activated BCR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448629", "l": "IL33 binds IL1RL1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9668395", "l": "CHMP7 binds CC2D1B (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013024", "l": "RHOB binds effectors at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603784", "l": "PEX19:class I PMP binds PEX3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800279", "l": "TP53 binds the PIDD1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38622", "l": "nicotinate beta-D-ribonucleotide + phenol <=> H(+) + nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31060", "l": "H2O + imidazole-4-acetaldehyde + NAD(+) => 2 H(+) + imidazole-4-acetate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12697", "l": "ATP + dGMP = ADP + dGDP"}, {"i": "EC:2.7.4.12", "l": "\"T(2)-induced deoxynucleotide kinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0043208", "l": "glycosphingolipid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5250217", "l": "ARL2:GTP binds ARL2BP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798474", "l": "S100A8:S100A9 binds Zn2+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205118", "l": "TRAF6 polyubiquitinates NRIF (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52176", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051750", "l": "delta3,5-delta2,4-dienoyl-CoA isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687088", "l": "PKA phosphorylates MAPKAPK5 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660662", "l": "ASC binds Caspase-8 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51421", "l": "a (2S,3S)-flavan-3-ol + 2 NADP(+) => an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37068", "l": "[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine => 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66061", "l": "2-oxohexanoate + L-kynurenine => H2O + kynurenate + L-2-aminohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9606887", "l": "p-CD19:VAV binds PI3K and GRB2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31483", "l": "soyasapogenol E + UDP-alpha-D-glucuronate = H(+) + soyasapogenol E 3-O-beta-D-glucuronate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141367", "l": "Myristoylation of tBID by NMT1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044600", "l": "protein guanylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-517674", "l": "p-S158,221-HuR binds mRNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53292", "l": "H2O + L-5-[2-(methysulfanyl)ethyl]hydantoin = H(+) + N-carbamoyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15014", "l": "3alpha(S)-strictosidine + H2O => secologanin + tryptamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222006", "l": "STK11 (LKB1) phosphorylates NUAK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106357", "l": "glycerol-1-phosphate dehydrogenase [NAD+] activity"}, {"i": "RHEA:21412", "l": "NAD(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADH"}, {"i": "EC:1.1.1.261", "l": "\"sn-glycerol-1-phosphate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004665", "l": "prephenate dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809764", "l": "SBF1 binds MTMR2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27718", "l": "H2O + IMP = inosine + phosphate"}, {"i": "EC:3.1.3.99", "l": "\"IMP-specific 5'-nucleotidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3858475", "l": "ppDVL recruits RAC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368069", "l": "NR1D1 (REV-ERBA) binds heme, the ARNTL gene, and recruits corepressors. (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65578", "l": "an alpha-D-glucuronosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + H(+) + UDP => a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47551", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oate <=> 3-oxochola-4,6-dien-24-oate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623643", "l": "RDH13 reduces atRAL to atROL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48658", "l": "5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19359", "l": "formaldehyde + H2O + N-methyl-L-proline + NADP(+) => H(+) + L-proline betaine + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2299620", "l": "Collagen XI cross-links with collagen II (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052765", "l": "reduced coenzyme F420 oxidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048101", "l": "calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60262", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849882", "l": "SALMs 1-4 bind reticulon 3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132269", "l": "Formation of classical C5 convertase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29527", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}, {"i": "EC:2.4.1.258", "l": "\"Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2404142", "l": "atROL binds RBP1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43020", "l": "L,L-cystathionine = 2-aminoprop-2-enoate + L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25547", "l": "ent-copalyl diphosphate <=> diphosphate + ent-pimara-9(11),15-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.1.8", "l": "\"Protein-disulfide reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47946", "l": "(2E)-geranyl phosphate + H(+) + phosphate => (2E)-geranyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139899", "l": "Sequestration of BAD protein by 14-3-3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58826", "l": "aureothin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => 4 H(+) + luteothin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21694", "l": "CMP + 2 H(+) + sn-glycerol 3-phosphate => CDP-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174438", "l": "Formation of the Flap Intermediate on the C-strand (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65532", "l": "2-methylbutan-1-ol + hexanoyl-CoA = 2-methylbutyl hexanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44583", "l": "4-hydroxy-3-all-trans-decaprenylbenzoate + H(+) <=> 2-all-trans-decaprenylphenol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46097", "l": "3-phenylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4 CO2 + 4 CoA + dihydropinosylvin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031521", "l": "NR1H2,3 binds the APOC2 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58635", "l": "N-tetradecanoyl-(2S)-hydroxyglycine <=> glyoxylate + tetradecamide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004788", "l": "thiamine diphosphokinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12716", "l": "a nucleoside 5'-phosphate + ATP <=> a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43835", "l": "5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA <=> 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706393", "l": "RHOBTB3 binds ATP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391377", "l": "Luteinizing hormone receptor can bind LH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41930", "l": "NADP(+) + octadecanoyl-[ACP] => (2E)-octadecenoyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41658", "l": "NADPH + sanguinarine => dihydrosanguinarine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.15"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16736", "l": "H(+) + orsellinate <=> CO2 + orcinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647980", "l": "mature RAS proteins translocate to plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65090", "l": "asperaculane G + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => asperaculane E + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1364044", "l": "PRLR:JAK2 dimerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63580", "l": "20-hydroxyecdysone 22-phosphate + H2O = 20-hydroxyecdysone + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57407", "l": "NAD(+) + narcotine hemiacetal <=> H(+) + NADH + noscapine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009014", "l": "succinyl-diaminopimelate desuccinylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375135", "l": "Basigin binds Matrix metalloproteinase-1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62547", "l": "2 [Fe(II)cytochrome c] + 3 H(+) + ouabagenin <=> 2 [Fe(III)cytochrome c] + dihydroouabagenin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55900", "l": "chloride + FADH2 + L-tryptophan + O2 = 6-chloro-L-tryptophan + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43159", "l": "guanosine(9) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49913", "l": "(R)-carnitine(out) + O-propanoyl-(R)-carnitine(in) => (R)-carnitine(in) + O-propanoyl-(R)-carnitine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33845", "l": "sphinganine + tetracosanoate => H2O + N-tetracosanoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64045", "l": "(13Z)-docosenoyl-CoA + sphing-4-enine => CoA + H(+) + N-(13Z-docosenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23044", "l": "H(+) + N,N-dihydroxy-L-tyrosine = (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53003", "l": "17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D-glucuronate <=> 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961982", "l": "RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62432", "l": "a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806610", "l": "Keratin filament formation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62037", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O => a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38624", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5682011", "l": "LC3 binds ATG7 dimer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24887", "l": "(R)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+) => D-glutamate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63759", "l": "flavokermesate + UDP-alpha-D-glucose <=> flavokermesate 7-C-beta-D-glucoside + 2 H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432010", "l": "Aquaporin-1 passively transports water into cell (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008030", "l": "neuronal pentraxin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42034", "l": "2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41502", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3134953", "l": "DHX36 or DHX9 binds MyD88 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0090681", "l": "GPCR taste receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37927", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46622", "l": "(9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-532549", "l": "MPI isomerises Fru6P to Man6P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928619", "l": "PAK1 binds RAC1:GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805981", "l": "HMGB1 release from cells (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66254", "l": "AMP + diphosphate + IC-asc-C7-CoA => ATP + CoA + IC-asc-C7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17645", "l": "H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] = N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51314", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675431", "l": "PP2A dephosphorylates RAF1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63415", "l": "2,4,6-trichlorophenol + FADH2 + O2 <=> 2,6-dichlorobenzoquinone + chloride + FAD + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018814", "l": "RHOT1 hydrolyzes GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46507", "l": "dodecanoyl-AMP + holo-[ACP] <=> AMP + dodecanoyl-[ACP] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647746", "l": "EML4 trimerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48133", "l": "(2E,6E)-farnesyl phosphate + H2O => (2E,6E)-farnesol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953339", "l": "DNPH1 hydrolyses dGMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388817", "l": "ICOS binds ICOSL/B7-H2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54136", "l": "cytidine(48) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(48) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54186", "l": "a carboxylate + an aromatic L-alpha-amino acid => an N-acyl-aromatic L-alpha-amino acid + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034538", "l": "3-methylsalicylaldehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15130", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] => (1S,6R)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046522", "l": "S-methyl-5-thioribose kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110307", "l": "REV1 binds AP-dsDNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9037612", "l": "H antigen-sec translocates from Golgi lumen to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64619", "l": "(E)-coniferol + acetyl-CoA <=> (E)-coniferyl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15786", "l": "2 6-iminocyclohexa-2,4-dienone + A => 2-aminophenoxazin-3-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29880", "l": "ATP + H2O + L-arginine(out) => ADP + H(+) + L-arginine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218805", "l": "PKC autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30103", "l": "2,5-didehydro-D-gluconate + H(+) + NADH = 5-dehydro-D-gluconate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22134", "l": "ADP + D-maltose(in) + H(+) + phosphate => ATP + D-maltose(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23327", "l": "2'-phospho-[ligated tRNA] + NAD(+) <=> ADP-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49464", "l": "2,6-dihydroxybenzoate + H(+) = CO2 + resorcinol"}, {"i": "EC:4.1.1.103", "l": "\"Gamma-resorcylate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28246", "l": "(R)-pantoate + ATP = (R)-4-phosphopantoate + ADP + H(+)"}, {"i": "EC:2.7.1.169", "l": "\"Pantoate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867098", "l": "Glycophorins bind plasmodium falciparum Ags (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161946", "l": "5S-HpETE is reduced to 5S-HETE by GPX1/2/4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034022", "l": "3-(hydroxyamino)phenol mutase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54128", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213207", "l": "Formation of collagen networks (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052848", "l": "inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity"}, {"i": "MetaCyc:RXN-10976"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53995", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59260", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) + H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63461", "l": "(2E,6E,10E)-geranylgeraniol + GTP => (2E,6E,10E)-geranylgeranyl phosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009927", "l": "histidine phosphotransfer kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376117", "l": "JLP interacts with CDO complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15801", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}, {"i": "RHEA:36231", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}, {"i": "EC:3.1.1.4", "l": "\"Phospholipase A(2)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-561072", "l": "OCT3 mediates renal uptake of organic cations (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626038", "l": "EEF1A1 binds GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53153", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37143", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804724", "l": "MDM2 ubiquitinates phosphorylated MDM4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19442", "l": "benzene-1,2,4-triol + O2 => 3-hydroxy-cis,cis-muconate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37592", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA => 1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.178", "l": "\"2-dehydro-3-deoxyglucono/galactono-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32725", "l": "(E)-6-(methylsulfanyl)hexanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-trihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052668", "l": "CTP:farnesol kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21243", "l": "geranylgeranyl diphosphate + L-cysteinyl-[protein] <=> diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23684", "l": "(S)-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] = allocryptopine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.97", "l": "\"Methyltetrahydroprotoberberine 14-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39065", "l": "H(+) + NADPH + scyllo-inosose => NADP(+) + scyllo-inositol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0070696", "l": "transmembrane receptor protein serine/threonine kinase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27453", "l": "iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24701", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A <=> 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + a 1,2-diacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19096", "l": "2 H(+) + siroheme <=> 12,18-didecarboxysiroheme + 2 CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3781941", "l": "WNTs are secreted in exosomes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27955", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + presilphiperfolan-8beta-ol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034561", "l": "1,2-bis(4-hydroxyphenyl)-2-proponol dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77094", "l": "Formation of cap binding complex (CBC) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66363", "l": "(7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H2O <=> (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199046", "l": "Ligands bind L-selectin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27536", "l": "(3R,6E)-nerolidol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15080", "l": "H(+) + N-[(R)-pantothenoyl]-L-cysteine <=> (R)-pantetheine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211193", "l": "Homodimerization  of DFF40 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033778", "l": "7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1638845", "l": "CERK phosphorylates CERA to form C1P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389523", "l": "BTLA interacts with HVEM (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60702", "l": "a 1-acyl-sn-glycero-2,3-cyclic phosphate + choline => a 1-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24777", "l": "H2O + pheophorbide a => C-13(2)-carboxypyropheophorbide a + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.2", "l": "\"Pepsin B\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-178189", "l": "SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9612501", "l": "SGK phosphorylates CREB1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204600", "l": "Basigin homodimerises (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8873850", "l": "STARD5 binds DCA, LCA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019161", "l": "diamine transaminase activity"}, {"i": "RHEA:18217", "l": "2-oxoglutarate + an alkane-alpha,omega-diamine = an omega-aminoaldehyde + L-glutamate"}, {"i": "EC:2.6.1.29", "l": "\"Diamine transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53313", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190519", "l": "Internalization of gap junction plaques (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36281", "l": "3-methylxanthine + formaldehyde + H2O + NAD(+) => H(+) + NADH + O2 + theophylline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54450", "l": "an N-acyl-L-amino acid + H(+) + tRNA => H2O + N-acyl-L-alpha-aminoacyl-tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18809", "l": "L-alanine + oxomalonate = aminomalonate + pyruvate"}, {"i": "EC:2.6.1.47", "l": "\"Alanine--oxomalonate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050460", "l": "hydroxylamine reductase (NADH) activity"}, {"i": "RHEA:20581", "l": "H2O + NAD(+) + NH4(+) = 2 H(+) + hydroxylamine + NADH"}, {"i": "EC:1.7.1.10", "l": "\"Hydroxylamine reductase (NADH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23911", "l": "2 [methionine synthase]-methylcob(III)alamin + H(+) + NADP(+) + 2 S-adenosyl-L-homocysteine <=> 2 [methionine synthase]-cob(II)alamin + NADPH + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56058", "l": "genistein 7-O-beta-D-glucoside + H(+) + UDP => genistein + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12917", "l": "3alpha(S)-strictosidine + H2O = D-glucose + strictosidine aglycone"}, {"i": "EC:3.2.1.105", "l": "\"3-alpha-(S)-strictosidine beta-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676589", "l": "RANKL,sRANKL trimer binds RANK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30505", "l": "acetate + L-glutamate 5-semialdehyde => H2O + N-acetyl-L-glutamate 5-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41782", "l": "CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide => beta-D-Gal-(1<->1')-Cer + CMP-N-acetyl-beta-neuraminate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001066", "l": "plastid single subunit type RNA polymerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28148", "l": "3''-hydroxygeranylhydroquinone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => geranylhydroquinone + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47566", "l": "ganglioside GA2 (d18:1(4E)) + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-427514", "l": "eNoSC deacetylates histone H3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1799329", "l": "Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8960973", "l": "RLBP1:11cRAL dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005298", "l": "proline:sodium symporter activity"}, {"i": "REACT:R-HSA-444100", "l": "PROT mediates L-proline uptake (Homo sapiens)"}, {"i": "RHEA:28967", "l": "L-proline(in) + Na(+)(in) = L-proline(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603784", "l": "PEX19:class I PMP binds PEX3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28484", "l": "beta-nicotinamide D-ribonucleotide(out) => beta-nicotinamide D-ribonucleotide(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45167", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51839", "l": "(9Z)-tetradecenoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (9Z)-tetradecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071837", "l": "HMG box domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6804100", "l": "HMGB1 binds LPS (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22861", "l": "ATP + H(+) + nicotinate beta-D-ribonucleotide => deamido-NAD(+) + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32733", "l": "a fatty acid + a monoacylglycerol + H(+) => a diacylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3239014", "l": "MAPKAPK5 phosphorylates TP53 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052916", "l": "23S rRNA (guanine(1835)-N(2))-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.65", "l": "\"(d)CTP diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102705", "l": "serine decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66242", "l": "AMP + diphosphate + IC-asc-C9-CoA => ATP + CoA + IC-asc-C9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4717406", "l": "Defective DPM1 does not transfer mannose to DOLP to form DOLPman (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42243", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + tetradecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649701", "l": "NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417927", "l": "P2Y2 receptor binds ATP and UTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374298", "l": "Opioid receptors bind opioid peptides (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432067", "l": "Aquaporin-4 passively transports water out of cell (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44773", "l": "2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + NADPH + O2 => 2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49456", "l": "(2S)-2-amino-4-deoxychorismate + H2O = (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate + pyruvate"}, {"i": "EC:3.3.2.15", "l": "\"Trans-2,3-dihydro-3-hydroxyanthranilic acid synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58589", "l": "dihydroprecondylocarpine acetate + NADPH => (+)-vincadifformine + acetate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31889", "l": "tirucalladienol => (S)-2,3-epoxysqualene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42464", "l": "biphenyl-2,2',3-triol + O2 = 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22686", "l": "(2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O => 4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854981", "l": "SHC1 in the RET complex is phosphorylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322431", "l": "XIAP binds TLE (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54079", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + stellata-2,6,19-triene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65049", "l": "4-acetoxybenzyl alcohol + NAD(+) => 4-acetoxybenzaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15670", "l": "5'-dephospho-(DNA) + ATP => ADP + H(+) + phospho-5'-(DNA)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36274", "l": "caffeine + H(+) + NADPH + O2 <=> formaldehyde + H2O + NADP(+) + theobromine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55773", "l": "a jasmonate + an L-alpha-amino acid + ATP => a jasmonyl-L-amino acid + AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49931", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-443439", "l": "c-Src binds Raf1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30585", "l": "2-demethylmenaquinone-8 + H2O + trimethylamine => 2-demethylmenaquinol-8 + H(+) + trimethylamine N-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58678", "l": "H2O + NADP(+) + rifamycin SV para-naphthoquinone carboxamide => NADPH + O2 + rifamycin SV"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36601", "l": "NADH + sulfur => hydrogen sulfide + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37593", "l": "1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869568", "l": "NPM1 binds TFAP2A homodimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205649", "l": "p62 links damaged mitochondria to LC3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26460", "l": "acetaldehyde + FMN + 2 H(+) + H2O + nitrite => ethylnitronate + FMNH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58239", "l": "L-tyrosyl-[protein] + NAD(+) <=> H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51754", "l": "a 2-acyl-4-prenylphloroglucinol + diphosphate => a 2-acylphloroglucinol + dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47702", "l": "H2O + iso-precytochalasin + NADP(+) => H(+) + ketocytochalasin + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849878", "l": "PSD-95 binds NMDA receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45689", "l": "N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(in) => N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34512", "l": "N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250220", "l": "Homodimerization of ERBB4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8949580", "l": "F1Fo ATP synthase dimerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683718", "l": "Protein M localizes to the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11866", "l": "dimethylamine + formaldehyde + reduced [electron-transfer flavoprotein] => H(+) + H2O + oxidized [electron-transfer flavoprotein] + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21924", "l": "3-dehydro-L-gulonate + NAD(+) = 2,3-dioxo-L-gulonate + H(+) + NADH"}, {"i": "RHEA:21928", "l": "3-dehydro-L-gulonate + NADP(+) = 2,3-dioxo-L-gulonate + H(+) + NADPH"}, {"i": "EC:1.1.1.130", "l": "\"3-dehydro-L-gulonate 2-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3321918", "l": "Defective MTR does not transfer CH3 group from MTHF to cob(I)alamin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694438", "l": "GalNAc is transferred onto 3a (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357429", "l": "AXL autophosphorylates on Y772 and Y814 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857328", "l": "RPS6KA1/2/3 phosphorylates CEBPB on S321 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693319", "l": "CTRC hydrolyses PRSS1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446634", "l": "IRAK4 is activated by autophosphorylation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873830", "l": "STARD7 transports PC from ER membrane to mitochondrial outer membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63435", "l": "1,2,3-tri-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + a di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41395", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49025", "l": "L-tryptophan + O2 => 2-iminio-3-(indol-3-yl)propanoate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848023", "l": "Activated PTK6 binds STAP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45130", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029456", "l": "RAC1 and CDC42 activate PAK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-421831", "l": "trans-Golgi Network Coat Assembly (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35331", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63558", "l": "dynorphin A-(1-12) + L-lysine => dynorphin A-(1-13) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55700", "l": "an inositol phosphomannosylinositol-1-phospho-N-acyl-(4R)-4-hydroxysphinganine + H2O = an N-acyl-(4R)-4-hydroxysphinganine + H(+) + mannosyldiinositol-1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51111", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0042912", "l": "colicin transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192061", "l": "CYP46A1 24-hydroxylates CHOL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49106", "l": "5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester => Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371554", "l": "HSF1 acetylation at Lys80 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47995", "l": "H(+)(in) + NAD(+) + NADPH <=> H(+)(out) + NADH + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3249378", "l": "STING recruits TBK1 and STAT6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10258", "l": "[(1->4)-3,6-bisphospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate => [(1->4)-6-phospho-alpha-D-glucosyl](n) + n ATP + n H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66181", "l": "ATP + bilirubin-glucuronoside(in) + H2O => ADP + bilirubin-glucuronoside(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34484", "l": "4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA => 4-hydroxybenzalacetone + 2 CO2 + 2 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9007447", "l": "E2F6 forms the PRC1L4 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240787", "l": "E2F1/2/3 stimulates SUZ12 transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49618", "l": "2-hydroxy-2-methylpropanoate + 2 H(+) + NADH => 2-hydroxy-2-methylpropanal + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5444523", "l": "Formation of MSH1:PMS2 Complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36301", "l": "(E)-caffeoyl-CoA + AMP + diphosphate => (E)-caffeate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353444", "l": "Cleavage of thymine by TDG glycosylase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18892", "l": "D-glucose 6-phosphate + UDP-alpha-D-glucose <=> alpha,alpha-trehalose 6-phosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674022", "l": "BRAP autoubiquitinates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56901", "l": "globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine => globoside GlcNAc-(beta1->6)-GalGb4Cer + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204873", "l": "Interaction of Tie2 and Shp2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24706", "l": "(6S)-10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose = (6S)-5,6,7,8-tetrahydrofolate + H(+) + UDP-4-deoxy-4-formamido-beta-L-arabinose"}, {"i": "EC:2.1.2.13", "l": "\"UDP-4-amino-4-deoxy-L-arabinose formyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0016160", "l": "amylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080042", "l": "ADP-glucose pyrophosphohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40773", "l": "(20S)-ginsenoside F1 + D-glucose => (20S)-ginsenoside Rg1 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24999", "l": "N-hydroxy-L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605724", "l": "Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21929", "l": "3-dehydro-L-gulonate + NADP(+) => 2,3-dioxo-L-gulonate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088309", "l": "FOXM1 binds CCNB2 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53173", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphate + ethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5631885", "l": "PRDX1 overoxidizes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102213", "l": "in-chain hydroxy fatty acyl-CoA synthetase activity"}, {"i": "MetaCyc:RXN-12184"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710353", "l": "GSDMD (1-275) binds cardiolipin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65440", "l": "a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidyl-adenosine in mRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57889", "l": "a quinone + 5 H(+)(in) + NADH => a quinol + 4 H(+)(out) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879910", "l": "JAK2 is phosphorylated, activated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48011", "l": "2-hydroxybenzoyl-CoA + H(+) + NADH + O2 <=> 2,5-dihydroxybenzoyl-CoA + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59898", "l": "ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate => ATP + L-glutamate + L-propargylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60345", "l": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854303", "l": "TBC1D11 binds RAB6 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102526", "l": "8-demethylnovobiocic acid C8-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28502", "l": "NAD(+) + S-(hydroxymethyl)mycothiol = H(+) + NADH + S-formylmycothiol"}, {"i": "EC:1.1.1.306", "l": "\"S-(hydroxymethyl)mycothiol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009918", "l": "sterol delta7 reductase activity"}, {"i": "MetaCyc:RXN-707"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44482", "l": "3-methoxy-4-hydroxy-5-all-trans-heptaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-heptaprenylbenzoate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "68.661248405853954", "identifiers": [{"i": "GO:0016860", "l": "intramolecular oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938217", "l": "RUNX1 binds the SWI/SNF complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26092", "l": "(4S)-limonene + H(+) + NADH + O2 <=> H2O + limonene 1,2-epoxide + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74740", "l": "Binding of SHC1 to insulin receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43842", "l": "(3beta)-hydroxy-cholest-5-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 26-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45993", "l": "(3R)-3-hydroxydecanoyl-CoA => (2E)-decenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805479", "l": "TP53RK phosphorylates TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27592", "l": "(R)-pantothenate + ADP + H(+) + phosphate => (R)-pantoate + ATP + beta-alanine"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015191", "l": "L-methionine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51469", "l": "(R)-lactate + a quinone => a quinol + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62327", "l": "(+)-malbrancheamide B + chloride + FAD + 2 H(+) <=> (+)-malbrancheamide + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848663", "l": "ADIPOQ trimer binds ADIPOR dimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874082", "l": "MET phosphorylates PTK2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41204", "l": "1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951977", "l": "Acetylated RUNX3 binds to BRD2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21622", "l": "FMN + 2 H(+) + NADH => FMNH2 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202325", "l": "Recruitment of Gads to LAT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61633", "l": "5-aminopentanal + H2O + NAD(+) => 5-aminopentanoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5631885", "l": "PRDX1 overoxidizes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928604", "l": "SFKs phosphorylate VAV2,3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57799", "l": "4-nitrotoluene + NADH + O2 <=> 4-methylcatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-217255", "l": "FMO1:FAD N-oxidises TAM (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57735", "l": "A + all-trans-7,8-dihydroretinol <=> AH2 + all-trans-retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111264", "l": "Addition of nucleotides between position +11 and +30 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39497", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+) => 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22693", "l": "3-hydroxybenzoate + H(+) + NADH + O2 => 2,5-dihydroxybenzoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66461", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O => 14betaH-scalarane-17alpha-19-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874191", "l": "CREB3L2 translocates from the cytosol to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0052671", "l": "geranylgeraniol kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37537", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34633", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin] => 5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52872", "l": "17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0005165", "l": "neurotrophin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615348", "l": "AGT(34-41) binds to AGTR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34129", "l": "cannabigerolate + diphosphate => (2E)-geranyl diphosphate + olivetolate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23137", "l": "a primary amine + S-adenosyl-L-methionine => a methylated primary amine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46054", "l": "U6 RNA 3'-terminal uridine 2',3'-cyclic phosphate + uridine => U6 RNA 3'-terminal UU"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424486", "l": "Phosphorylation and activation of VAV2/VAV3 by SYK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30122", "l": "dodecanoyl-[ACP] + H2O <=> dodecanoate + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41366", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043424", "l": "protein histidine kinase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018901", "l": "5-HEDH dehydrogenates 5(S)-Hp-18(R)-HpEPE to 18(R)-RvE2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25606", "l": "2-(5-methylsulfanyl)oxopentanoate + acetyl-CoA + H2O => 2-(3-methylsulfanyl)propylmalate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46289", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8871366", "l": "p-Y281,292-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008811", "l": "chloramphenicol O-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.18.1", "l": "\"Tyrosinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40772", "l": "(20S)-ginsenoside Rg1 + H2O => (20S)-ginsenoside F1 + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014812", "l": "ROBOs bind keratan sulfate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936462", "l": "PIN1 mediated IRF3 degradation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001066", "l": "amylopectin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16545", "l": "formyl-CoA + oxalate = formate + oxalyl-CoA"}, {"i": "EC:2.8.3.16", "l": "\"Formyl-CoA transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570528", "l": "SUMOylation of XPC with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57795", "l": "3,4-dinitrotoluene + NADH + O2 <=> 4-methyl-6-nitrocatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623280", "l": "PCK1 gene expression is stimulated by FOXO1:PPARGC1A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167481", "l": "Abortive termination of HIV-1 elongation after arrest (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004535", "l": "poly(A)-specific ribonuclease activity"}, {"i": "REACT:R-HSA-429955", "l": "CCR4-NOT complex deadenylates mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769401", "l": "DKK and KRM bind LRP5/6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44501", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16807", "l": "CO2 + deacetylcephalosporin C + succinate => 2-oxoglutarate + deacetoxycephalosporin C + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199425", "l": "PHLPP dephosphorylates S473 in AKT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51256", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate + O2 = (9S,16S)-dihydroperoxy-(10E,12Z,14E)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030342", "l": "1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity"}, {"i": "REACT:R-HSA-211950", "l": "CYP24A1 24-hydroxylates CTL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64263", "l": "(9Z,12Z)-octadecadienoyl-CoA + glycine <=> CoA + H(+) + N-(9Z,12Z-octadecadienoyl)-glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34549", "l": "ADP + cob(II)yrinate c monoamide + H(+) + L-glutamate + phosphate => ATP + cob(II)yrinate + H2O + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174119", "l": "Free APC/C phosphorylated by Plk1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17060", "l": "a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP] <=> a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015115", "l": "silicate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38518", "l": "1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602712", "l": "TICAM1 deficiency blocks TLR3 pathway (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49188", "l": "a bacteriochlorophyllide d = a 3-vinylbacteriochlorophyllide d + H2O"}, {"i": "EC:4.2.1.169", "l": "\"3-vinylbacteriochlorophyllide d 3(1)-hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64107", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + O-phospho-L-seryl-[protein] <=> 1D-myo-inositol hexakisphosphate + O-diphospho-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17659", "l": "a 1-acylglycerone 3-phosphate + CoA => an acyl-CoA + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139941", "l": "Binding of IP3 to IP3 receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917839", "l": "apo-Transferrin dissociates from the receptor complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047821", "l": "D-glutamate oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156682", "l": "PLK1 phosphorylates NUDC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213244", "l": "Loading of antigenic peptides (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66406", "l": "ADP + glutathione(out) + H(+) + phosphate + taurocholate(out) => ATP + glutathione(in) + H2O + taurocholate(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047512", "l": "(S,S)-butanediol dehydrogenase activity"}, {"i": "KEGG.REACTION:R03707"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848110", "l": "SOCS3 binds activated PTK6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56680", "l": "beta-dihydromenaquinone-9 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.15.27", "l": "\"Beta-dihydromenaquinone-9 omega-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39953", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432946", "l": "PARVB/Affixin interacts with alpha PIX (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70510", "l": "LDH tetramer oxidises LACT to PYR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61750", "l": "H(+) + stevioside + UDP => rubusoside + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0004177", "l": "aminopeptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43056", "l": "5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH = 10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+)"}, {"i": "EC:2.3.1.239", "l": "\"10-deoxymethynolide syntase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63961", "l": "abscisate(out) + ATP + H2O => abscisate(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204773", "l": "Interaction of Tie2 and Grb7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.124", "l": "\"Protein deglycase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983156", "l": "Polyubiquitination of substrate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614591", "l": "Excess cysteine yields lanthionine and H2S (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392752", "l": "Phosphorylation of L1 by CK-II (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49282", "l": "catechol + FAD + H(+) + H2O => FADH2 + O2 + phenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209924", "l": "Dopa is decarboxylated to dopamine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31265", "l": "but-3-yn-1-ol + pyrroloquinoline quinone => but-3-ynal + H(+) + pyrroloquinoline quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672969", "l": "Phosphorylation of RAF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52368", "l": "3'-phosphoadenylyl sulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol sulfate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195726", "l": "Association of  NA into rafts (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374701", "l": "Phosphorylation of DCC by Fyn (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12602", "l": "2-oxoglutarate + L-2-aminoadipate => 2-oxoadipate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43359", "l": "cholesteryl (9Z,12Z)-octadecadienoate(in) <=> cholesteryl (9Z,12Z)-octadecadienoate(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003978", "l": "UDP-glucose 4-epimerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709406", "l": "CO binds to Cytochrome c oxidase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693081", "l": "FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649742", "l": "Defective SLC33A1 does not transport Ac-CoA from cytosol to Golgi lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53633", "l": "(2E,6E)-farnesyl diphosphate => (3S)-(+)-asterisca-2(9),6-diene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106362", "l": "protein-arginine N-acetylglucosaminyltransferase activity"}, {"i": "RHEA:66632", "l": "L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976768", "l": "Factor H binds to C3b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34704", "l": "(2E,6E)-farnesyl diphosphate => (E)-2-epi-beta-caryophyllene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483197", "l": "PTPMT1 dephosphorylates PGP to PG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62870", "l": "H2O + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate + NADP(+) => 9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59456", "l": "NADP(+) + tetradecan-1-ol = H(+) + NADPH + tetradecanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40976", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O => 2 H(+) + 2 hexadecanoate + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52534", "l": "AMP + GDP + H(+) => adenosine + GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66289", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-D-mannosyl-alpha-1->6-inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56357", "l": "3-bromo-4-hydroxybenzoate + bromide + 3 H(+) + NADPH + O2 => 2,4-dibromophenol + CO2 + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015167", "l": "arabitol transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19075", "l": "ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein] => ATP + L-seryl-[I-kappa-B protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14244", "l": "3-amino-4-hydroxybenzaldehyde + acetyl-CoA <=> 3-acetylamino-4-hydroxybenzaldehyde + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12290", "l": "an alcohol + L-fucose => an alpha-L-fucoside + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1250280", "l": "ROS oxidize thioredoxin (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013143", "l": "RAC1 GEFs activate RAC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322429", "l": "XIAP monoubiquinates TLE (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665989", "l": "DIAPH1 binds RHOA:GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62113", "l": "(3S)-3-hydroxy-D-aspartate => H2O + iminosuccinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198508", "l": "malate + NAD+ <=> oxaloacetate + NADH + H+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17428", "l": "CoA + NADP(+) + pyruvate <=> acetyl-CoA + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853444", "l": "AURKA phosphorylates PHLDA1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592371", "l": "Initial activation of proMMP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851436", "l": "CFHR dimers bind C3b (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374667", "l": "DCC interaction with SIAH2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28189", "l": "aminoacetone + H2O + O2 <=> H2O2 + methylglyoxal + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35606", "l": "beta-D-fructose 1-phosphate + H2O <=> D-fructose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33535", "l": "H2O + lanosteryl ester = a carboxylate + H(+) + lanosterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174660", "l": "nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.89", "l": "\"Arabinogalactan endo-beta-1,4-galactanase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201790", "l": "DARPP-32 is dephosphorylated on Thr75 by PP2A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37771", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26031", "l": "2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,3'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871260", "l": "YAP1 binds TEAD2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373736", "l": "Shootin-1 links L1 and retrograde actin flow (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5660660", "l": "p300 acetylates RELA subunit (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357432", "l": "AXL binds SRC-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351894", "l": "Caspase mediated cleavage of BAP31 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25257", "l": "N-acetyl-D-glucosamine 6-phosphate = N-acetyl-D-mannosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62091", "l": "D-glucosamine 6-phosphate + NADP(+) <=> 2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810843", "l": "Envoplakin binds periplakin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63291", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 9-hydroperoxy-(5Z,7E,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68615", "l": "Formation of ORC(1-6) complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950533", "l": "Expression of Ras-related protein Ral-A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36371", "l": "(2S)-hydroxybutanoate + NAD(+) = 2-oxobutanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16923", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37082", "l": "2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388503", "l": "Oxytocin receptor bind oxytocin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23948", "l": "4-hydroxybutanoate + NAD(+) = H(+) + NADH + succinate semialdehyde"}, {"i": "EC:1.1.1.61", "l": "\"4-hydroxybutyrate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390912", "l": "HRH1 binds hist (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53759", "l": "allodeoxycholoyl-CoA + cholate <=> allodeoxycholate + choloyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696457", "l": "BDH2 dehydrogenates 3HBA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23084", "l": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 7-methyl-3-oxooct-6-enoyl-CoA + acetate"}, {"i": "EC:4.1.3.26", "l": "\"3-hydroxy-3-isohexenylglutaryl-CoA lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27800", "l": "all-trans-octaprenyl diphosphate + 5 diphosphate => (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25203", "l": "D-arabino-hex-3-ulose 6-phosphate => D-ribulose 5-phosphate + formaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432129", "l": "FGR binds and phosphorylates LRP8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60460", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58123", "l": "ATP + L-seryl-[protein] <=> 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445084", "l": "Phosphorylation of L1 by SRC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53035", "l": "2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 17beta-estradiol 2-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11051", "l": "1-organyl-2-lyso-sn-glycero-3-phospholipid + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine <=> 1-O-alkyl-sn-glycero-3-phosphocholine + 1-organyl-2-acetyl-sn-glycero-3-phospholipid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28289", "l": "a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35158", "l": "(S)-4,5-dihydroxypentane-2,3-dione <=> (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33588", "l": "acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate => CoA + H(+) + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33033", "l": "D-sorbitol + NAD(+) => D-fructose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56212", "l": "O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP"}, {"i": "RHEA:56216", "l": "O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP"}, {"i": "EC:2.4.1.102", "l": "\"Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50067", "l": "ATP + H2O + taurochenodeoxycholate(in) <=> ADP + H(+) + phosphate + taurochenodeoxycholate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050211", "l": "procollagen galactosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034876", "l": "isonicotinic acid hydrazide hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730904", "l": "Auto-ubiquitination of TRAF6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8957241", "l": "TP73 tetramer translocates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448728", "l": "IL19 binds IL20RA:JAK1:IL20RB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090633", "l": "keto-deoxynonulosonic acid (KDN) cytidylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371537", "l": "DBC1 binds SIRT1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28752", "l": "sn-glycerol 3-phosphate + ubiquinone-8 => dihydroxyacetone phosphate + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40765", "l": "(20S)-ginsenoside Rg1 + L-rhamnopyranose => (20S)-ginsenoside Re + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362427", "l": "Hh-Np binds GPC5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102075", "l": "OPC4-trans-2-enoyl-CoA hydratase activity"}, {"i": "MetaCyc:RXN-10705"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20140", "l": "10-deacetylbaccatin III + acetyl-CoA <=> baccatin III + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59112", "l": "ATP + L-serine = ADP + H(+) + O-phospho-L-serine"}, {"i": "EC:2.7.1.225", "l": "\"L-serine kinase (ATP)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043015", "l": "gamma-tubulin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036430", "l": "CMP kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47340", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61022", "l": "5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine => acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65565", "l": "(9Z)-octadecenoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11719", "l": "a monoamide of a dicarboxylate + H2O <=> a dicarboxylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57808", "l": "1-chloro-3-nitrobenzene + NADH + O2 = 3-chlorocatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11757", "l": "ATP + biotin + L-lysyl-[protein] => AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983707", "l": "SYK autophosphorylates at the activated BCR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0035515", "l": "oxidative RNA demethylase activity"}, {"i": "REACT:R-HSA-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050108", "l": "monoterpenyl-diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36587", "l": "an aldopyranose + NADP(+) = aldono-1,5-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27578", "l": "(R)-N-tert-butylpiperazine-2-carboxamide + H2O = (R)-piperazine-2-carboxylate + tert-butylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27952", "l": "L-phenylalanine(out) => L-phenylalanine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46049", "l": "D-galactosamine 6-phosphate => alpha-D-galactosamine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65513", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + O2 => 5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61626", "l": "5-aminopentanal + L-glutamate => 2-oxoglutarate + cadaverine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24749", "l": "L-methionine <=> 2-aminobut-2-enoate + methanethiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43238", "l": "1,2-dihexadecanoyl-sn-glycerol + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70830", "l": "tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54776", "l": "1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine = [LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29003", "l": "H(+)(out) + L-homoserine(in) = H(+)(in) + L-homoserine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58384", "l": "NADP(+) + octan-1-ol = H(+) + NADPH + octanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41014", "l": "(+)-sesamin + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n <=> (+)-sesamin monocatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60927", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2 <=> CO2 + formaldehyde + L-lysyl-[protein] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34251", "l": "1-deoxysphinganine + NADP(+) = 1-deoxy-3-dehydrosphinganine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39287", "l": "[Co(I) trimethylamine-specific corrinoid protein] + H(+) + trimethylamine = [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine"}, {"i": "EC:2.1.1.250", "l": "\"[Trimethylamine--corrinoid protein] Co-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52857", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209133", "l": "Formation of the 'destruction complex' (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13214", "l": "H2O + NADP(+) + succinate semialdehyde => 2 H(+) + NADPH + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706356", "l": "CBL mutants don't ubiquitinate FLT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53241", "l": "cholesta-5,7-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65771", "l": "a 1,1-dimethyl-3-phenylurea + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395768", "l": "LPL hydrolyses TGs from mature CMs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65768", "l": "a 1,1-dimethyl-3-phenylurea + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.15.38", "l": "\"N,N-dimethyl phenylurea N-demethylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450387", "l": "HuR binds the CRM1 nuclear export machinery (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.13.-", "l": "\"Protein-histidine kinases\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106255", "l": "hydroperoxy icosatetraenoate isomerase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032840", "l": "intramolecular proline-rich ligand binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097030", "l": "CENP-A containing nucleosome binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17771", "l": "betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.2.2", "l": "\"Nebramycin 5' synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69299", "l": "CDT1 binds geminin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18943", "l": "a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + H(+) + NADPH => a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18942", "l": "a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+) => a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.6"}]}
{"type": "biolink:MolecularActivity", "ic": "74.378130331796413", "identifiers": [{"i": "GO:0022843", "l": "voltage-gated cation channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432054", "l": "Aquaporin-1 passively transports water out of cell (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198714", "l": "ERK5 translocates to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47333", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450259", "l": "Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14934", "l": "H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] => N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004190", "l": "aspartic-type endopeptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35209", "l": "H(+) + IMP + phosphate => H2O + IDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004146", "l": "dihydrofolate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37780", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186819", "l": "SH2 domain of Src binds to the active receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20675", "l": "4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH => 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989765", "l": "Expression of ABCA1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371467", "l": "SIRT1 deacetylates HSF1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.7.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30324", "l": "all-trans-beta-carotene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "49.373707502880201", "identifiers": [{"i": "GO:0022857", "l": "transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879222", "l": "MDP:NLRP1 binds ATP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033954", "l": "alpha-neoagaro-oligosaccharide hydrolase activity"}, {"i": "MetaCyc:3.2.1.159-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47582", "l": "ganglioside GT2 (d18:1(4E)) + H(+) + UDP => ganglioside GT3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19285", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + di-trans,poly-cis-dolichol = a 1-acyl-sn-glycero-3-phosphocholine + acyldolichol"}, {"i": "EC:2.3.1.83", "l": "\"Phosphatidylcholine--dolichol O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43420", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + ATP = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62780", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033755", "l": "sulfur oxygenase/reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56076", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696605", "l": "USP12, USP26 deubiquitinate AR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607740", "l": "PKC-delta phosphorylates CARD9 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18226", "l": "[N-(6-aminohexanoyl)](n) + H2O => 6-aminohexanoate + [N-(6-aminohexanoyl)](n-1)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621289", "l": "PINK1 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42000", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = H(+) + isogloboside iGb3Cer (d18:1(4E)) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55899", "l": "chloride + FADH2 + L-tryptophan + O2 <=> 5-chloro-L-tryptophan + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.-", "l": "\"Acting on GTP; involved in cellular and subcellular movement\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730851", "l": "Phosphorylation of SLP-76 by p-SYK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944233", "l": "Association of procollagen type XIX (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205306", "l": "Interaction of SHP1 and KIT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791121", "l": "Expression of XBP1(S) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20794", "l": "AMP + diphosphate + L-lysyl-tRNA(Lys) => ATP + L-lysine + tRNA(Lys)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878654", "l": "ACP6 hydrolyses MYS-LPA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189488", "l": "UROS transforms HMB to URO3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018611", "l": "toluate dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32414", "l": "(1R,2R,4S)-isodihydrocarveol + NAD(+) <=> (1R,4S)-isodihydrocarvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710106", "l": "ELANE cleaves GSDMD (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099580", "l": "ion antiporter activity involved in regulation of postsynaptic membrane potential"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64655", "l": "(E)-4-coumaraldehyde + CoA + NADP(+) <=> (E)-4-coumaroyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296233", "l": "T2Rs bind bitter-tasting compounds (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57051", "l": "AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] <=> 2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24769", "l": "7(1)-hydroxychlorophyllide a + NAD(+) => chlorophyllide b + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1254291", "l": "ERBB4s80 binds STAT5A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004166", "l": "dolichyl-phosphate alpha-N-acetylglucosaminyltransferase activity"}, {"i": "MetaCyc:2.4.1.153-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666129", "l": "CDC42:GTP recruits DIAPH2-2 to kinetochores (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0070004", "l": "cysteine-type exopeptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6791016", "l": "SFTPB binds itself (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050238", "l": "pyridoxine 5-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111264", "l": "Addition of nucleotides between position +11 and +30 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202731", "l": "JAM3 dimerises (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162836", "l": "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46150", "l": "a 2'-deoxyribonucleoside + H(+) + triphosphate => a 2'-deoxyribonucleoside 5'-triphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59491", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate <=> ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017017", "l": "MAP kinase tyrosine/serine/threonine phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051538", "l": "3 iron, 4 sulfur cluster binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102036", "l": "methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508451", "l": "PTK2B is phosphorylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033759", "l": "flavone synthase activity"}, {"i": "MetaCyc:RXN-8000"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448958", "l": "Nuclear translocation of p38 MAPK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23565", "l": "2 columbamine + O2 => 2 berberine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59350", "l": "D-maltobionate + H(+) => D-maltobiono-1,5-lactone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102713", "l": "gibberellin A25 hydroxylase activity"}, {"i": "MetaCyc:RXN-6543"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2301205", "l": "SETD8 monomethylates histone H4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654623", "l": "Activated FGFR3 binds FRS3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24085", "l": "all-trans-zeaxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => all-trans-antheraxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51429", "l": "acetyl-CoA + aminomethylphosphonate => 2-N-acetamidomethylphosphonate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41966", "l": "(2E)-butenoyl-CoA + H2O2 => butanoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63664", "l": "(S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADPH = H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110218", "l": "Cleavage of uracil by TDG glycosylase (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13464", "l": "3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + H(+) + NADPH + O2 <=> 2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55844", "l": "calcidiol + UDP-alpha-D-glucuronate = calcidiol 3-O-(beta-D-glucuronide) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45170", "l": "2 CoA + 2 H(+) + N(1),N(8)-bis[(E)-sinapoyl]-spermidine => 2 (E)-sinapoyl-CoA + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25791", "l": "4-hydroxy-2-oxoheptanedioate <=> pyruvate + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17437", "l": "2,4-dichloro-5-oxo-2,5-dihydro-2-furylacetate = (2E,4E)-2,4-dichloromuconate + H(+)"}, {"i": "EC:5.5.1.11", "l": "\"Dichloromuconate cycloisomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14090", "l": "2-oxoglutarate + glycine => glyoxylate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34238", "l": "4-nitro-6-oxohepta-2,4-dienedioate <=> 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9011748", "l": "IL9R binds JAK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32068", "l": "8-oxoguanine + H(+) + H2O => NH4(+) + urate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102243", "l": "ATP:geranylgeraniol phosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698923", "l": "Binding of the major capsid protein (MCP) to the pPR-AP:pAP complex  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27585", "l": "2-(hydroxymethyl)glutarate <=> 2-methyleneglutarate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59710", "l": "D-maltotrionate + H(+) => D-maltotriono-1,5-lactone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944230", "l": "Association of procollagen type XVIII (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47540", "l": "7-oxolithocholate + H(+) + NADPH = NADP(+) + ursodeoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32418", "l": "(1S,2S,4R)-isodihydrocarveol + NAD(+) <=> (1S,4R)-isodihydrocarvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24490", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44349", "l": "ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate => ADP + dapdiamide B + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.2.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10872", "l": "H2O + N-acyl-L-aspartate = a carboxylate + L-aspartate"}, {"i": "EC:3.5.1.15", "l": "\"Aspartoacylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17142", "l": "glycine + oxaloacetate => glyoxylate + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55141", "l": "D-alanyl-5'-AMP + holo-[D-alanyl-carrier protein] => AMP + D-alanyl-[D-alanyl-carrier protein] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62225", "l": "H(+) + NADPH + neopatulin => (E)-ascladiol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12847", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate => [L-4-(L-arginin-2-N-yl)aspartate](n) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59885", "l": "2-oxoglutarate + chloride + H(+) + L-lysine + O2 => 4-chloro-L-lysine + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578712", "l": "Importin-8 binds AGO2:miRNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204600", "l": "Basigin homodimerises (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33524", "l": "ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + H2O => acetate + ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56763", "l": "24,25-dihydrolanosterol + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3134946", "l": "DDX41 ubiquitination by TRIM21 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28450", "l": "N(6)-(D-psicosyl)-L-lysine(in) = N(6)-(D-psicosyl)-L-lysine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25187", "l": "2-chloroethanol + chloride + H(+) => 1,2-dichloroethane + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2993802", "l": "HLCS biotinylates PC:Mn2+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75096", "l": "Docking of the TAP:EJC Complex with the NPC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28726", "l": "(S)-allantoin(in) + H(+)(in) <=> (S)-allantoin(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952069", "l": "HDAC4 deacetylates RUNX3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176973", "l": "Association of MCM8 with ORC:origin complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110307", "l": "REV1 binds AP-dsDNA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11421", "l": "NADPH + O2 + senecionine => H2O + NADP(+) + senecionine N-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186819", "l": "SH2 domain of Src binds to the active receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950581", "l": "Expression of Cofilin-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39841", "l": "a triacyl-sn-glycerol + CoA => a 2,3-diacyl-sn-glycerol + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10873", "l": "H2O + N-acyl-L-aspartate => a carboxylate + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1006169", "l": "Factor H binds host cell surface markers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166220", "l": "FA anion diffuses laterally to UCP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952442", "l": "SPP1 gene expression is stimulated by RUNX3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55019", "l": "H(+) + menthone + NADPH + O2 <=> 7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950190", "l": "Expression of PAK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619478", "l": "CAMKK2 phosphorylates AMPK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2993802", "l": "HLCS biotinylates PC:Mn2+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420724", "l": "CASR binds Ca2+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47091", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) <=> 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8940134", "l": "FOLR2 binds FOLA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016316", "l": "phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64188", "l": "an N-(fatty acyl)-L-tyrosine + H2O = a fatty acid + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196964", "l": "RFK:Mg2+ phosphorylates RIB (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52376", "l": "(+)-sesamin monocatechol + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n = (+)-sesamin dicatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109639", "l": "Formation of the closed pre-initiation complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0051192", "l": "prosthetic group binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211206", "l": "Translocation of DFF to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047390", "l": "glycerophosphocholine cholinephosphodiesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2485180", "l": "MII catalyses GDP/GTP exchange on Gt (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12647", "l": "CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + S-2-(indol-3-yl)acetyl-CoA => CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60673", "l": "NAD(+) + nerol => H(+) + NADH + neral"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60285", "l": "N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24589", "l": "ATP + D-arabinose => ADP + D-arabinose 5-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437243", "l": "Doublecortin binds phosphorylated neurofascin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14088", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA <=> 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18259", "l": "2 CO2 + 2 H2O + protoporphyrinogen IX => coproporphyrinogen III + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51725", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate => adenosine 5'-tetraphosphate + ADP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54571", "l": "a uridine in rRNA <=> a pseudouridine in rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447034", "l": "CHL1 interacts with Ankyrin-G (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097253", "l": "beta-hydroxybutyrate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54348", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5658438", "l": "SPRED dimer binds NF1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36716", "l": "sphinganine + tetracosenoyl-CoA => an N-tetracosenoylsphinganine + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48259", "l": "(2S)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869549", "l": "TFPA2A homodimer and NPM1 bind the MYBL2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22251", "l": "7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) <=> 7,8-dihydroxykynurenate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12715", "l": "a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+) => a nucleoside 5'-phosphate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9009282", "l": "CDK1 phosphorylates RUNX2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56339", "l": "ent-isokaurene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> ent-isokaurene-2beta,3beta-diol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22457", "l": "creatine + H2O => sarcosine + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855648", "l": "SALM3 binds LAR-RPTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655241", "l": "Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086216", "l": "Collagen type VII binds integrin alpha2beta1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48458", "l": "2-octanoyl-3-O-beta-D-galactosyl-sn-glycerol + H(+) + octanoate => 1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2213201", "l": "Formation of collagen fibres (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.74", "l": "\"Venombin A\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5683925", "l": "ULK1 is dephosphorylated (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43014", "l": "2-aminobut-2-enoate + H(+) + hydrogen sulfide => L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928625", "l": "PAKs autophosphorylate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938053", "l": "RUNX1:CBFB binds the SERPINB13 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9649735", "l": "Intrinsic nucleotide exchange on RAS (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799431", "l": "TP53 binds HIPK1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36493", "l": "(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371422", "l": "ATP hydrolysis by HSP70 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48676", "l": "6-trans-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-6-trans-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18453", "l": "[(1->2)-beta-D-glucosyl](n)(in) + ATP + H2O = [(1->2)-beta-D-glucosyl](n)(out) + ADP + H(+) + phosphate"}, {"i": "EC:7.5.2.3", "l": "\"ABC-type beta-glucan transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.37", "l": "\"2',3'-cyclic-nucleotide 3'-phosphodiesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661625", "l": "FVIII is secreted (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55806", "l": "(9Z)-octadecenoate + (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-sn-glycerol) + H(+) => (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'-(9Z-octadecenoyl)-3'-sn-glycerol) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66431", "l": "D-arabinose(out) + H(+)(out) <=> D-arabinose(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47837", "l": "[5-(aminomethyl)-3-furyl]methyl phosphate + ATP => [5-(aminomethyl)furan-3-yl]methyl diphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417898", "l": "P2Y4 receptor can bind to UTP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177937", "l": "Phosphorylation of EGFR by SRC kinase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8954082", "l": "E2F6 binds the PRC1 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52420", "l": "O-phospho-L-serine + thiosulfate = phosphate + S-sulfo-L-cysteine"}, {"i": "EC:2.8.5.1", "l": "\"S-sulfo-L-cysteine synthase (3-phospho-L-serine-dependent)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404135", "l": "RBP4 binds atROL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1974676", "l": "Beta defensin 103 activates TLR1:TLR2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662851", "l": "Defective DCXR does not reduce L-xylulose to xylitol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56946", "l": "1-deoxy-D-xylulose 5-phosphate + A + H2O => AH2 + D-ribulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56641", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42340", "l": "4-(gamma-L-glutamylamino)butanal + H2O + NAD(+) = 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32790", "l": "ATP + H2O + L-ectoine(out) <=> ADP + H(+) + L-ectoine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30270", "l": "2 monodehydro-L-ascorbate radical <=> L-ascorbate + L-dehydroascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210298", "l": "Interaction of DAP12 and KIR3DS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909726", "l": "Phosphorylation of STAT1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9660557", "l": "RAS:GTP binds RAL GDS proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28954", "l": "H(+)(in) + L-arabinose(in) <=> H(+)(out) + L-arabinose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30855", "l": "dammarenediol-II = (S)-2,3-epoxysqualene + H2O"}, {"i": "EC:4.2.1.125", "l": "\"Dammarenediol II synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51574", "l": "(25S)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47630", "l": "3-methylmalate + CoA + H(+) => glyoxylate + H2O + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14273", "l": "A + H2O + spermidine = 4-aminobutanal + AH2 + propane-1,3-diamine"}, {"i": "EC:1.5.99.6", "l": "\"Spermidine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18956", "l": "L-erythro-7,8-dihydrobiopterin + NADP(+) <=> H(+) + NADPH + sepiapterin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19666", "l": "6-carboxyhexanoyl-CoA + NAD(+) => 6-carboxyhex-2-enoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56562", "l": "[1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP => [1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44110", "l": "2 H(+) + heptanoate + NADH => H2O + heptanal + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5432825", "l": "HMGB1 binds TLR4:LY96 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73596", "l": "dCMP + H2O => dUMP + NH4+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14450", "l": "chlorophyllide a + NADP(+) => 3,8-divinyl chlorophyllide a + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848316", "l": "IL36 binds IL1RL2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949609", "l": "Formation of MIB complex containing the MICOS complex causes curvature of mitochondrial inner membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35004", "l": "L-fucose(in) => L-fucose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38891", "l": "H2O + N-hexadecanoylsphing-4-enine = hexadecanoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13021", "l": "4-hydroxy-3-methoxybenzoate + H(+) + NADH + O2 = 3,4-dihydroxybenzoate + formaldehyde + H2O + NAD(+)"}, {"i": "EC:1.14.13.82", "l": "\"Vanillate monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66036", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49063", "l": "a long-chain alkane + FMNH2 + O2 <=> a long chain fatty alcohol + FMN + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870678", "l": "Cleaved fibrinogen products bind TLR4:LY96 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12636", "l": "benzoate + H(+) + NADH + O2 <=> (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48973", "l": "ATP + H2O + phosphite(out) => ADP + H(+) + phosphate + phosphite(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15858", "l": "17alpha,20alpha-dihydroxypregn-4-en-3-one + NADP(+) => 17alpha-hydroxyprogesterone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983144", "l": "Transport of Antigen peptide in to ER (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3640862", "l": "Tankyrase binds AXIN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008327", "l": "methyl-CpG binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200406", "l": "CPT1A,B transfers PALM to CAR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25114", "l": "phosphate + pyridoxine => H2O + pyridoxine 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21202", "l": "(S)-2-amino-6-oxohexanoate + L-glutamate => 2-oxoglutarate + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14537", "l": "1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H(+) + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH4(+)"}, {"i": "EC:3.5.4.20", "l": "\"Pyrithiamine deaminase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106334", "l": "3'-deoxyribose phosphate lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29103", "l": "5 H(+)(in) + menaquinone-8 + NADH = 4 H(+)(out) + menaquinol-8 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396007", "l": "IRF3 is phosphorylated by TBK1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480515", "l": "Expression of FGF2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176879", "l": "apolipoprotein(a) + LDL => Lp(a) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55862", "l": "all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59805", "l": "L-phenylalanine => D-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052690", "l": "trichloro-p-hydroquinone reductive dehalogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3266566", "l": "G6PC2 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (islet) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24939", "l": "(R)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+) = D-glutamate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.20"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.15.1.-", "l": "\"Acting on superoxide as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64990", "l": "adenosine 3',5'-bisphosphate + D-pantetheine 4'-phosphate + 2 H(+) => CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56674", "l": "(E)-4-coumaroyl-CoA + H(+) + NADPH => dihydro-4-coumaroyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52291", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44187", "l": "D-sedoheptulose 7-phosphate <=> 2-epi-5-epi-valiolone + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130478", "l": "Interaction of invariant chain trimer and MHC II alpha beta dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047872", "l": "dolichol O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38744", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-octadecenoyl)-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63131", "l": "H2O + N-docosanoyl-ethanolamine <=> docosanoate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35136", "l": "L-alanyl-L-glutamate(out) => L-alanyl-L-glutamate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798489", "l": "S100A7 or S100A7A binds Zn2+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59674", "l": "D-maltotriono-1,5-lactone + H2O2 => D-maltotriose + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166175", "l": "TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5663050", "l": "DHI and DHICA polymerise forming eumelanin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32708", "l": "(2E)-geranyl diphosphate => (2R,4S)-bornyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404200", "l": "IGF1,2 binds IGF1R (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694732", "l": "3CLp cleaves pp1ab (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33601", "l": "2 [Fe(III)-cytochrome b5] + H2O + N-hexacosanoyl-(4R)-hydroxysphinganine => 2 [Fe(II)-cytochrome b5] + 2 H(+) + N-hexacosanoylsphinganine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004835", "l": "tubulin-tyrosine ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10892", "l": "(2R,3S)-3-isopropylmalate + NAD(+) = (2S)-2-isopropyl-3-oxosuccinate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-844447", "l": "NLRP1 senses MDP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23426", "l": "D-glucosamine 6-phosphate => alpha-D-glucosamine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0089719", "l": "RHG protein domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20441", "l": "L-cysteine + O2 = 3-sulfino-L-alanine + H(+)"}, {"i": "EC:1.13.11.20", "l": "\"Cysteine dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210294", "l": "Interaction of PECAM-1 and SHP-2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46805", "l": "a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine => a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40706", "l": "(9Z,12Z)-octadecadien-1-ol + 1-hexadecanoylglycerone 3-phosphate <=> 1-O-(9Z,12Z)-octadecadienylglycerone 3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63925", "l": "ATP + N(4)-acetylcytidine => ADP + H(+) + N(4)-acetylcytidine 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047559", "l": "3-dehydro-L-gulonate 2-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53403", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> (13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40238", "l": "coenzyme B + coenzyme M + fumarate <=> coenzyme M-coenzyme B heterodisulfide + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67091", "l": "ATP + H2O + tetracosanoate(in) <=> ADP + H(+) + phosphate + tetracosanoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-378952", "l": "Thyrotropin is a heterodimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322434", "l": "XIAP dissociates from ub-TLE (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29218", "l": "fumarate + menaquinol-8 <=> menaquinone-8 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43609", "l": "agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O => 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186819", "l": "SH2 domain of Src binds to the active receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769394", "l": "AKT phosphorylates CBY1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42901", "l": "guanosine(745) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41809", "l": "(3R)-hydroxybutanoyl-[ACP] => (2E)-butenoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2509838", "l": "ITPA hydrolyses dITP to dIMP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36629", "l": "CoA + H(+) + N-(2-hydroxytetracosanoyl)-sphinganine => 2-hydroxytetracosanoyl-CoA + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51048", "l": "5alpha-androstan-3,17-dione + A = AH2 + androst-4-ene-3,17-dione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807106", "l": "PTEN undergoes monoubiquitination (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17778", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32566", "l": "(2E)-geranyl diphosphate <=> alpha-terpinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45364", "l": "H2O + N-(11Z-eicosenoyl)-(4R)-hydroxysphinganine = (11Z)-eicosenoate + (4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "73.153983691316824", "identifiers": [{"i": "GO:0015298", "l": "solute:cation antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20344", "l": "sn-glycerol 3-phosphate + UDP-alpha-D-galactose <=> 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.55"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018499", "l": "cis-2,3-dihydrodiol DDT dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034584", "l": "piRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65464", "l": "2-methylbutan-1-ol + butanoyl-CoA = 2-methylbutyl butanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-213407", "l": "Disassociation of PLC-gamma1 from SLP-76 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26122", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44832", "l": "(R)-carnitine + tetradecanoyl-CoA = CoA + O-tetradecanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65917", "l": "L-kynurenine + pyruvate => H2O + kynurenate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40028", "l": "9alpha-copalyl diphosphate + H2O => (13S)-vitexifolin A + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944255", "l": "Association of procollagen type VII (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12845", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O = [L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate"}, {"i": "EC:3.4.15.6", "l": "\"Cyanophycinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2327733", "l": "FN1 binds Collagen types I-V, VII (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51672", "l": "glyoxal + H2O = glycolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13088", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O <=> CoA + L-2-acetamido-6-oxoheptanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64374", "l": "alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + N-acetyl-D-galactosamine => beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012205", "l": "Estrogen-responsive CHD1 gene transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60039", "l": "H2O + N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate <=> 3-hydroxy-3-methylhexanoate + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-901047", "l": "Binding of ERp57 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592297", "l": "Full activation of MMP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19279", "l": "AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl) => ATP + L-pyrrolysine + tRNA(Pyl)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1254251", "l": "ERBB4s80 binds YAP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102789", "l": "UDP-D-glucose:cyanidin 5-O-beta-D-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-8005"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45261", "l": "tetracosanoate(out) => tetracosanoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866269", "l": "ARRB bind GPCRs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2002466", "l": "Formation of allysine by LOX (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17341", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + H(+) + NADPH"}, {"i": "RHEA:36175", "l": "1-O-alkylglycerone 3-phosphate + H(+) + NADPH = 1-O-alkyl-sn-glycero-3-phosphate + NADP(+)"}, {"i": "EC:1.1.1.101", "l": "\"Acylglycerone-phosphate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158795", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64260", "l": "(9Z,12Z)-octadecadienoyl-CoA + glycine = CoA + H(+) + N-(9Z,12Z-octadecadienoyl)-glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11799", "l": "ecdysone + O2 <=> 3-dehydroecdysone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28123", "l": "ATP + di-trans,octa-cis-undecaprenol => ADP + di-trans,octa-cis-undecaprenyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21913", "l": "CoA + H(+) + O2 + pyruvate => acetyl-CoA + CO2 + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47604", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) = CMP + ganglioside GP1calpha (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41334", "l": "(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13671", "l": "3-hydroxy-2-methylpyridine-5-carboxylate + CO2 => 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031879", "l": "type 2 somatostatin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018807", "l": "RAC3 GDIs block activation of RAC3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102377", "l": "steviol 13-O glucosyltransferase activity"}, {"i": "MetaCyc:RXN-13511"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19144", "l": "all-trans-retinol <=> 11-cis-retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17064", "l": "H(+) + NADPH + O2 + phenol <=> catechol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24134", "l": "UDP-alpha-D-galactofuranose => UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804425", "l": "TP53 binds POU4F2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693250", "l": "RHOD binds effectors at the Golgi membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635804", "l": "ATF4 and phospho-ATF2 bind the DDIT3 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033428", "l": "CAG codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432537", "l": "PP2A dephosphorylates phosphorylated CLK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029272", "l": "Release of PLCG from FCGR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429449", "l": "Syk activation leads to SLP-76 activation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266328", "l": "CETP-mediated lipid exchange: spherical HDL gains triacylglycerol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32851", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol = a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35320", "l": "H(+) + malonyl-CoA + octadecanoyl-CoA => 3-oxoeicosanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250280", "l": "ROS oxidize thioredoxin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416358", "l": "G alpha (q) inhibits PI3K alpha (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693761", "l": "FA2H hydroxylates CERA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48736", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.337", "l": "\"Reticuline N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66128", "l": "2-oxobutanoate + L-phenylalanine = (2S)-2-aminobutanoate + 3-phenylpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41398", "l": "1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981931", "l": "RAC1 and CDC42 activate PAK2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35968", "l": "fumitremorgin C + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 12alpha,13alpha-dihydroxyfumitremorgin C + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50676", "l": "H(+) + H2O + N-terminal L-asparaginyl-[protein] = N-terminal L-aspartyl-[protein] + NH4(+)"}, {"i": "EC:3.5.1.121", "l": "\"Protein N-terminal asparagine amidohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58927", "l": "(3R,4R)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-4,7-diol <=> (-)-maackiain + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5687088", "l": "PKA phosphorylates MAPKAPK5 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32242", "l": "gamma-carotene <=> all-trans-beta-carotene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19736", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+) <=> bacteriochlorophyllide a + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22707", "l": "2 H2O + ricinine <=> 4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29571", "l": "H(+)(in) + L-idonate(in) = H(+)(out) + L-idonate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166542", "l": "beta-NGF dimer binds to TrkA receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22606", "l": "D-fructose => D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035517", "l": "Defective AVP mutants do not bind AVPR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16475", "l": "5-oxohexanoate + H(+) => cyclohexane-1,3-dione + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38002", "l": "2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + S-adenosyl-L-methionine <=> H(+) + plastoquinol-9 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50754", "l": "2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) + 2 H2O => 2 naphthalene-1,2,4,8-tetrol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-203977", "l": "SAR1 Activation And Membrane Binding (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66392", "l": "ATP + H2O + prostaglandin E1(in) = ADP + H(+) + phosphate + prostaglandin E1(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33335", "l": "1,2-dioctadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dioctadecanoyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26288", "l": "Co-precorrin-5B + S-adenosyl-L-methionine <=> Co-precorrin-6A + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351901", "l": "Caspase-mediated cleavage of MST3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1067640", "l": "IL6 binds IL6R-2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19537", "l": "D-mannitol 1-phosphate + H2O = D-mannitol + phosphate"}, {"i": "EC:3.1.3.22", "l": "\"Mannitol-1-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1006143", "l": "CD46 binds C3b (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40996", "l": "3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA => 4-hydroxybenzaldehyde + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21681", "l": "(2S)-2-hydroxyphytanate + O2 => 2-oxophytanate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210918", "l": "pagA binds ANTXR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865275", "l": "PDGF-BB clevage by Furin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52184", "l": "(E)-(indol-3-yl)acetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] = 1-aci-nitro-2-(1H-indol-3-yl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0031753", "l": "endothelial differentiation G protein-coupled receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647746", "l": "EML4 trimerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63146", "l": "(15Z)-tetracosenoate + ethanolamine => H2O + N-(15Z-tetracosenoyl)-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52613", "l": "3-(methylsulfanyl)propanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => 3-(methylsulfanyl)acryloyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28957", "l": "D-glucuronate(out) + H(+)(out) => D-glucuronate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177284", "l": "PKA phosphorylates PDE4B (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11968", "l": "AH2 + kynurenate + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + A"}, {"i": "EC:1.14.99.2", "l": "\"Kynurenine 7,8-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60973", "l": "hexan-1-ol + NAD(+) => H(+) + hexanal + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001092", "l": "TFIIA-class transcription factor complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15624", "l": "an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25968", "l": "(S)-benzoin + NADP(+) = benzil + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047931", "l": "glucosamine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31302", "l": "H2O + NAD(+) + perillyl aldehyde <=> 2 H(+) + NADH + perillate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029451", "l": "Activation of RAC1 by VAV (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56151", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphocholine <=> CoA + hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.112", "l": "\"Site-1 protease\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64436", "l": "glycylglycyl-L-isoleucine(out) + H(+)(out) = glycylglycyl-L-isoleucine(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034906", "l": "N-isopropylaniline 1,2-dixoxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54825", "l": "H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein] => alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047276", "l": "N-acetyllactosaminide 3-alpha-galactosyltransferase activity"}, {"i": "RHEA:13013", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = an alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}, {"i": "EC:2.4.1.87", "l": "\"N-acetyllactosaminide 3-alpha-galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47749", "l": "a ubiquinone + H(+) + n Na(+)(in) + NADH => a ubiquinol + n Na(+)(out) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51812", "l": "ATP(in) + CoA(in) + H(+)(out) + tetradecanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + tetradecanoyl-CoA(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17450", "l": "(2E)-geranyl diphosphate + flaviolin => 3-linalylflaviolin + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45832", "l": "(3R)-3-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66295", "l": "an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose <=> an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803914", "l": "TP53 binds the RGCC gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63681", "l": "(7R,8S)-7,8-diammoniononanoate + CO2 => (7R,8S)-8-amino-7-(carboxyamino)nonanoate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210300", "l": "Interaction of DAP12 and TREM2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53295", "l": "H2O + L-5-[2-(methysulfanyl)ethyl]hydantoin <=> H(+) + N-carbamoyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004504", "l": "peptidylglycine monooxygenase activity"}, {"i": "RHEA:21452", "l": "a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 = a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical"}, {"i": "EC:1.14.17.3", "l": "\"Peptidylglycine monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12249", "l": "NADP(+) + UDP-N-acetyl-alpha-D-muramate => H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112727", "l": "Serine phosphorylation of STATs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70501", "l": "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.19", "l": "\"D-stereospecific aminopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-419166", "l": "GEFs activate RhoA,B,C (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011748", "l": "IL9R binds JAK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047172", "l": "shikimate O-hydroxycinnamoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38959", "l": "a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2"}, {"i": "EC:1.3.3.6", "l": "\"Acyl-CoA oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9647980", "l": "mature RAS proteins translocate to plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803892", "l": "SFN dimer binds BAX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395340", "l": "Formation of hydroxyallysine by LOX (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605051", "l": "Expression of PCK1 regulated by NR1H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50354", "l": "3 CO2 + 3 CoA + 3 H2O + 6 NADP(+) + trimethylated-mycocerosoyl-[mycocerosate synthase] => 3 (R)-methylmalonyl-CoA + 9 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 6 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666008", "l": "SCAI binds SRF:MKL1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-377644", "l": "Release of CSK from SRC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177926", "l": "Dephosphorylation of PAG by SHP2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614614", "l": "Cysteine is degraded to serine and H2S (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50810", "l": "prostaglandin J2-S-(S)-glutathione => glutathione + prostaglandin J2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372529", "l": "Release of acetylcholine at the synapse (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43909", "l": "beta-D-galactosyl-(1<->1)-sphing-4-enine + H2O => D-galactose + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45715", "l": "3-dehydrocarnityl-CoA + CoA <=> acetyl-CoA + N,N,N-trimethylglycyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36266", "l": "hydroxyurea + O-acetyl-L-serine <=> acetate + H(+) + O-ureido-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592240", "l": "Formation of NRF2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62526", "l": "H(+) + N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine => cytidine(839) in 12S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32769", "l": "2'-O-methylcytidine(4) in tRNA(Pro) + H(+) + S-adenosyl-L-homocysteine => cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44397", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1-heptadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37167", "l": "(2E,6E)-farnesol + NAD(+) = (2E,6E)-farnesal + H(+) + NADH"}, {"i": "EC:1.1.1.354", "l": "\"Farnesol dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37585", "l": "6-amino-2-oxohexanoate + H2O2 + NH4(+) => D-lysine + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24324", "l": "6-oxocineole + H(+) + NADPH + O2 = 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP(+)"}, {"i": "EC:1.14.13.51", "l": "\"6-oxocineole dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987120", "l": "JAK1 binds IFNLR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047923", "l": "gentisate decarboxylase activity"}, {"i": "KEGG.REACTION:R02489"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64963", "l": "dTDP + H2O <=> dTMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008741", "l": "ribulokinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42822", "l": "H2O + 2 NADP(+) + tetracenomycin C => 2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5681980", "l": "ATG12 binds ATG7 dimer (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45883", "l": "3-methylundecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11249", "l": "[(3R)-hydroxybutanoate](n) + H2O => (R)-3-hydroxybutanoate + [(3R)-hydroxybutanoate](n-1) + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008879", "l": "glucose-1-phosphate thymidylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424482", "l": "p85 regulatory unit of PI3K binds p-6Y-SYK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55132", "l": "ATP + D-alanine + holo-[D-alanyl-carrier protein] = AMP + D-alanyl-[D-alanyl-carrier protein] + diphosphate"}, {"i": "EC:6.2.1.54", "l": "\"D-alanine--[D-alanyl-carrier protein] ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047678", "l": "arginine 2-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392187", "l": "Activated P2Y purinoceptor 12 binds G-protein Gi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952069", "l": "HDAC4 deacetylates RUNX3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19181", "l": "a very-long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]"}, {"i": "EC:1.3.8.9", "l": "\"Very-long-chain acyl-CoA dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34667", "l": "C30 botryococcene + S-adenosyl-L-methionine = 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042931", "l": "enterobactin transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951486", "l": "CD46 binds C4b (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809309", "l": "MTMR6 binds MTMR9 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15502", "l": "2 L-glutamate + NADP(+) => 2-oxoglutarate + H(+) + L-glutamine + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59264", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-dihydroxybenzoyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16449", "l": "acetyl-CoA + kanamycin B = CoA + H(+) + N(6')-acetylkanamycin B"}, {"i": "EC:2.3.1.82", "l": "\"Aminoglycoside 6'-N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55709", "l": "[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) => [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683964", "l": "ATM phosphorylates EYA1-4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20442", "l": "L-cysteine + O2 => 3-sulfino-L-alanine + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032547", "l": "purine deoxyribonucleoside binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9005995", "l": "MECP2 binds the SIN3A co-repressor complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20670", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NAD(+) => 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "58.130644739604215", "identifiers": [{"i": "GO:0016835", "l": "carbon-oxygen lyase activity"}, {"i": "EC:4.2.-.-", "l": "\"Carbon-oxygen lyases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39964", "l": "2-hexadecanoylglycerol + H2O => glycerol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18292", "l": "(S,S)-tartrate <=> H2O + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034850", "l": "isooctane monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44367", "l": "2-epi-5-epi-valiolone + ATP <=> 2-epi-5-epi-valiolone 7-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070840", "l": "dynein complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380294", "l": "Loss of C-Nap-1 from centrosomes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46898", "l": "a 1,2-diacyl-sn-glycerol + lipid A hexaacyl 1-(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31922", "l": "indolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-hydroxyindolin-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61254", "l": "3-methyl-2-oxobutanoate + H2O2 + NH4(+) => H2O + L-valine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54284", "l": "H2O + N-(octadecanoyl)-sphing-4-enine-1-phosphocholine = H(+) + N-octadecanoylsphing-4-enine + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849085", "l": "ARHGAP35 binds RHOA:GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31441", "l": "alpha-longipinene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63097", "l": "ilicicolin A epoxide => ilicicolin C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11705", "l": "2 H(+) + N-(carboxyaminomethyl)urea => CO2 + N-(aminomethyl)urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29233", "l": "cyanate(out) + H(+)(out) => cyanate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15689", "l": "H(+) + L-2,4-diaminobutanoate = CO2 + propane-1,3-diamine"}, {"i": "EC:4.1.1.86", "l": "\"Diaminobutyrate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380272", "l": "Plk1-mediated phosphorylation of Nlp (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34289", "l": "2 H2O + 2 L-dopaquinone => 2 L-dopa + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18914", "l": "a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36648", "l": "2-hydroxyhexadecanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxyhexadecanoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37026", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 <=> (6Z)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000120", "l": "CBLIF binds Cbl (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30839", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-talose = UDP-N-acetyl-beta-L-fucosamine"}, {"i": "EC:5.1.3.28", "l": "\"UDP-N-acetyl-L-fucosamine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13758", "l": "(Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose => (Z)-desulfoglucotropeolin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062184", "l": "testosterone 16-beta-hydroxylase activity"}, {"i": "RHEA:46304", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45613", "l": "H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428609", "l": "Type I Na+-coupled phosphate co-transport (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001052", "l": "plastid PEP RNA polymerase core enzyme binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204798", "l": "Interaction of Tie2 and p85 of PI3K (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66339", "l": "L-glutamate(out) <=> L-glutamate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32623", "l": "L-threo-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40684", "l": "1-hexadecanoylglycerone 3-phosphate + dodecan-1-ol => 1-O-dodecylglycerone 3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15902", "l": "(2R)-2-phosphoglycerate => (2R)-3-phosphoglycerate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13204", "l": "glycine + L-arginine <=> guanidinoacetate + L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694433", "l": "MIA2 binds PREB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4411402", "l": "Activation of NLK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975175", "l": "MyD88 interacts with the activated TLR receptor 7, 8 or 9  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47006", "l": "L-threonyl-[protein] + phosphate => H2O + O-phospho-L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200406", "l": "CPT1A,B transfers PALM to CAR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904121", "l": "phosphatidylethanolamine transfer activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691131", "l": "CANDI binds CUL1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015255", "l": "propanediol channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62263", "l": "2 hydrogencarbonate(out) + Mn(2+)(out) <=> 2 hydrogencarbonate(in) + Mn(2+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65529", "l": "hexan-1-ol + octanoyl-CoA => CoA + hexyl octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33350", "l": "2-iminoacetate + H2O <=> glyoxylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169192", "l": "PTP1B dephosphorylates GHR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51186", "l": "H(+) + octadecanoate + sn-glycero-3-phospho-L-serine => 1-octadecanoyl-sn-glycero-3-phosphoserine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211731", "l": "Interaction of PAK-2p34 with RGH10/ PS-GAP results in accumulation of PAK-2p34 in the perinuclear region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44343", "l": "(S)-2,3-diaminopropanoate + ATP + fumarate <=> AMP + diphosphate + N(3)-fumaroyl-(S)-2,3-diaminopropanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66526", "l": "L-ascorbate(out) + monodehydro-L-ascorbate radical(in) => L-ascorbate(in) + monodehydro-L-ascorbate radical(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250600", "l": "botD:SV2:GD2 internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004623", "l": "phospholipase A2 activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62308", "l": "(+)-premalbrancheamide + chloride + FAD + 2 H(+) = (+)-malbrancheamide B + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9690461", "l": "FKBP1A binds tacrolimus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010898", "l": "ROBO2 binds SLIT2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18282", "l": "NAD(+) + succinate => fumarate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43390", "l": "1D-myo-inositol 3-phosphate + phosphate => 1D-myo-inositol 3,4-bisphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21593", "l": "(2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD(+) => H(+) + L-2-aminopentanoate + NADH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1222376", "l": "NOX2 generates superoxide from oxygen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42364", "l": "2 a 2-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56899", "l": "a carboxylate + ATP + H(+) <=> an acyl-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60519", "l": "L-tryptophan <=> D-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44728", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33049", "l": "(+)-6-endo-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin] => (1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20884", "l": "H2O + L-serine + NAD(+) = 3-hydroxypyruvate + H(+) + NADH + NH4(+)"}, {"i": "EC:1.4.1.7", "l": "\"Serine 2-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16442", "l": "H2O + L-glutaminyl-[protein] => L-glutamyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39341", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+) => (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13875", "l": "abieta-7,13-diene + diphosphate => (+)-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31296", "l": "(2E)-2-hydroxypenta-2,4-dienoate => 2-oxopent-4-enoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63336", "l": "alpha-D-xylose = beta-D-xylose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42105", "l": "2-hydroxyethylphosphonate + methylcob(III)alamin + S-adenosyl-L-methionine => (S)-2-hydroxypropylphosphonate + 5'-deoxyadenosine + cob(III)alamin + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43794", "l": "H(+) + N(1)-methyladenosine(645) in 25S rRNA + S-adenosyl-L-homocysteine => adenosine(645) in 25S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63199", "l": "(10bR,4aS)-noroxomaritidine + H(+) + NADPH <=> (10bR,4aS)-oxomaritidine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41239", "l": "N-acyl (9Z,12Z)-octadecadienoate octadecasphin-4E-enine + O2 = N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24703", "l": "NAD(+) + UDP-alpha-D-glucuronate => CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62801", "l": "2 7-demethylsiderin + NADPH + O2 => 2 H2O + NADP(+) + orlandin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045503", "l": "dynein light chain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60694", "l": "(E)-non-2-enoate + 2 H(+) + NADPH => (E)-non-2-enal + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46679", "l": "(4R)-hydroxy-(6R)-2,2,6-trimethylcyclohexanone + NAD(+) <=> (6R)-2,2,6-trimethyl-1,4-cyclohexanedione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8940554", "l": "MMP2 cleaves OPTC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158959", "l": "urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799350", "l": "Exocytosis of specific granule membrane proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36108", "l": "gibberellin A4 + S-adenosyl-L-methionine => O-methyl gibberellin A4 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334827", "l": "SUMO-CRABP2 binds atRA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33671", "l": "2 [Fe(III)-cytochrome b5] + an N-(2,3-dihydroxyhexacosanoyl)-(4R)-hydroxysphinganine + H2O = 2 [Fe(II)-cytochrome b5] + 2 H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55809", "l": "2 [Fe(II)-cytochrome b5] + a dihydroceramide + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a phytoceramide + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033786", "l": "heptose-1-phosphate adenylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103001", "l": "dimethylsulfoxide oxygenase activity"}, {"i": "RHEA:57956", "l": "dimethyl sulfoxide + H(+) + NADH + O2 = dimethyl sulfone + H2O + NAD(+)"}, {"i": "MetaCyc:RXN-9767"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25702", "l": "N-hydroxy-L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17658", "l": "an acyl-CoA + dihydroxyacetone phosphate => a 1-acylglycerone 3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015537", "l": "xanthosine:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678920", "l": "TLR processing at low pH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25623", "l": "tuberculosinyl diphosphate => geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58945", "l": "6 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 12 H(+) + malonyl-CoA + 6 NADPH => 7 CO2 + 8 CoA + demethyldeoxyspectinabilin + 5 H2O + 6 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40308", "l": "A + decanedioyl-CoA => (2E)-decenedioyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36127", "l": "gibberellin A34 + S-adenosyl-L-methionine = O-methyl gibberellin A34 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804596", "l": "APAF1:CYCS binds APIP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850534", "l": "PDCL promotes G-protein beta 5 folding (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675417", "l": "PEBP1 binds activated RAF1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033729", "l": "anthocyanidin reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12241", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH => 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16840", "l": "5'-acylphosphoadenosine + H2O <=> a carboxylate + AMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29836", "l": "D-galactonate(in) + H(+)(in) => D-galactonate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44719", "l": "A + all-trans-4,4'-diapolycopen-4-al + H2O <=> AH2 + all-trans-4,4'-diapolycopen-4-oate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36153", "l": "(E)-cinnamyl acetate + CoA => (E)-cinnamyl alcohol + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018747", "l": "RHOQ GEFs activate RHOQ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983144", "l": "Transport of Antigen peptide in to ER (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686578", "l": "Activated ATM phosphorylates ABL1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029268", "l": "Phosphorylation and activation of PLCG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621356", "l": "PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103054", "l": "gibberellin A12, 2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A15-forming)"}, {"i": "RHEA:60776", "l": "2-oxoglutarate + gibberellin A12 + O2 = CO2 + gibberellin A15 + succinate"}, {"i": "MetaCyc:RXN1F-162"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981622", "l": "Myoglobin:oxygen dissociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015164", "l": "glucuronoside transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46070", "l": "(2E)-nonenoyl-CoA => (3E)-nonenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61904", "l": "betaenone A + H(+) + NADPH + O2 = H2O + NADP(+) + stemphyloxin II"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47845", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) => CO2 + diphosphate + thiamine phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63327", "l": "1,2-dihexadecanoyl-sn-glycerol + ATP <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40184", "l": "O2 + tetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624120", "l": "CEBPA binds CDK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62997", "l": "(8Z,11Z,14Z)-eicosatrienamide + H2O => (8Z,11Z,14Z)-eicosatrienoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50151", "l": "a fatty acid ethyl ester + H2O <=> a fatty acid + ethanol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696810", "l": "RNase P cleaves the 5' end of pre-tRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59341", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene + A => 1'-hydroxy-demethylspheroidene + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373746", "l": "SEMA4D interacts with CD45 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31433", "l": "(-)-beta-santalene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23097", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27676", "l": "ADP + dATP => ATP + dADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22307", "l": "A + D-fructose <=> 5-dehydro-D-fructose + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193655", "l": "Myelin components can interact with p75NTR:NgR:LINGO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20522", "l": "(R)-3-hydroxybutanoate + NAD(+) => acetoacetate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050372", "l": "ubiquitin-calmodulin ligase activity"}, {"i": "MetaCyc:UBIQUITIN--CALMODULIN-LIGASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047144", "l": "2-acylglycerol-3-phosphate O-acyltransferase activity"}, {"i": "REACT:R-HSA-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-427514", "l": "eNoSC deacetylates histone H3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102089", "l": "dehydroscoulerine synthase activity"}, {"i": "MetaCyc:RXN-10888"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371591", "l": "Trimerization of cytosolic HSF1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814678", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33257", "l": "H(+) + menaquinol-7 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-7 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47271", "l": "bacterioruberin <=> H2O + monoanhydrobacterioruberin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042888", "l": "molybdenum ion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051747", "l": "cytosine C-5 DNA demethylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205244", "l": "Recruitment of CBL to KIT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14625", "l": "[(1->4)-alpha-D-glucosyl](n) + [(1->6)-alpha-D-glucosyl](n+1) = [(1->4)-alpha-D-glucosyl](n+1) + [(1->6)-alpha-D-glucosyl](n)"}, {"i": "EC:2.4.1.2", "l": "\"Dextrin dextranase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56808", "l": "ATP + cob(I)yrinate a,c diamide--[corrinoid adenosyltransferase] = adenosylcob(III)yrinate a,c-diamide + apo-[corrinoid adenosyltransferase] + triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-217255", "l": "FMO1:FAD N-oxidises TAM (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32602", "l": "7-hydroxy-4-isopropenyl-7-methyloxepan-2-one <=> 3-isopropenyl-6-oxoheptanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33682", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + N-tetracosanoylsphinganine + O2 <=> 2 [Fe(III)-cytochrome b5] + H2O + N-tetracosanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52986", "l": "6-carboxyhexanoyl-[ACP] + reduced [flavodoxin] => 7-oxoheptanoyl-[ACP] + H2O + oxidized [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49587", "l": "D-erythrulose 1-phosphate <=> L-erythrulose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34559", "l": "1-deoxy-11beta-hydroxypentalenate + NAD(+) = 1-deoxy-11-oxopentalenate + H(+) + NADH"}, {"i": "EC:1.1.1.340", "l": "\"1-deoxy-11-beta-hydroxypentalenate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49319", "l": "beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (5R,6S)-5,6-epoxi-beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47638", "l": "5-guanidino-2-oxopentanoate + H(+) + NADPH + NH4(+) => H2O + L-arginine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673288", "l": "ppDVL binds RAC1:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49436", "l": "cholate + deoxycholoyl-CoA = choloyl-CoA + deoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6795473", "l": "PDPK1 phosphorylates SGK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202709", "l": "JAM2 dimerises (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.-", "l": "\"Transferring groups other than amino-acyl groups\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050387", "l": "urethanase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47241", "l": "H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2172123", "l": "Interaction of SIGLEC14/15/16 and DAP12 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847880", "l": "CYTH proteins bind ARF1:GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40196", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65842", "l": "ATP(in) + Mg(2+)(in) + phosphate(out) => ATP(out) + Mg(2+)(out) + phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662606", "l": "MT3 binds zinc (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "80.661393760018115", "identifiers": [{"i": "GO:0008028", "l": "monocarboxylic acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41492", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16760", "l": "NADP(+) + trypanothione <=> H(+) + NADPH + trypanothione disulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5660980", "l": "p-S276-RELA binds RELB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76386", "l": "CYP1A2 S-demethylates 6MMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37228", "l": "(E,E)-sorbate + H(+) => (E)-1,3-pentadiene + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2423785", "l": "CR:atREs binds apoE and HSPG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212380", "l": "Formation of TRAP coactivator complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54780", "l": "[LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine = [LarE protein]-dehydroalanine + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654625", "l": "Activated FGFR3 binds SHC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678843", "l": "ISGylation of protein translation regulator 4EHP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25080", "l": "4-methyl-2-oxopentanoate + CO2 => (2S)-2-isopropyl-3-oxosuccinate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044012", "l": "histone acetyltransferase activity (H2A-K9 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110360", "l": "Recruitment of POLB to the AP site (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202328", "l": "Translocation of PKC theta to plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354060", "l": "Translocation of RIAM to plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18692", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989761", "l": "Expression of APOA5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31693", "l": "(9R)-hydroperoxy-(10E,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-265177", "l": "Exocyst complex formation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29686", "l": "alpha-maltohexaose + phosphate <=> alpha-D-glucose 1-phosphate + alpha-maltopentaose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43027", "l": "an S-substituted L-cysteine <=> 2-aminoprop-2-enoate + a thiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22815", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) <=> 5,10-methenyltetrahydrofolate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873919", "l": "Phosphorylation of JAK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218811", "l": "DOCK180:ELMO binds CRK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41062", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + octadecanoyl-CoA <=> 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399930", "l": "Activation of PAK by Rac1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64355", "l": "3 H(+) + hexanoyl-CoA + 3 malonyl-CoA <=> 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692755", "l": "CDK1 phosphorylates MAPK6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28020", "l": "2 H(+) + 3 N-(2,3-dihydroxybenzoyl)-L-serine => enterobactin + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26175", "l": "1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA <=> CoA + H(+) + mycothiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16886", "l": "2 bilirubin-glucuronoside => bilirubin IXalpha + bilirubin-bisglucuronoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15833", "l": "(S)-4-hydroxymandelate + H(+) + O2 = 4-hydroxybenzaldehyde + CO2 + H2O2"}, {"i": "EC:1.1.3.19", "l": "\"4-hydroxymandelate oxidase (decarboxylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805507", "l": "APAF1 binds AVEN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033858", "l": "N-acetylgalactosamine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23375", "l": "ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39898", "l": "7-deoxyloganetate + UDP-alpha-D-glucose <=> 7-deoxyloganate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729318", "l": "CSNK1A1 phosphorylates nucleoprotein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55970", "l": "(+)-O-methylkolavelool + H(+) + S-adenosyl-L-homocysteine => (+)-kolavelool + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66164", "l": "butanoyl-CoA + serotonin = CoA + H(+) + N-butanoylserotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380239", "l": "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687107", "l": "MAPK4,6 translocate to nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848339", "l": "PNPLA5 hydrolyzes TAG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213210", "l": "Collagen IX is cross-linked to the surface of collagen type II fibrils (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69142", "l": "Recruitment of Dna2 endonuclease (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41956", "l": "2',3'-cyclic CMP + H2O = cytidine 2'-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20142", "l": "an S-alkyl-L-cysteine S-oxide => 2-aminoprop-2-enoate + an S-alkyl sulfenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16335", "l": "diphosphate + holo-[citrate lyase ACP] => 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55216", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + rhizathalene A"}, {"i": "EC:4.2.3.195", "l": "\"Rhizathalene A synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222722", "l": "Mycobactin is exported (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606789", "l": "ARSB hydrolyses DS (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3791155", "l": "Laminin-322 degradation by MMP14 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2509827", "l": "ITPA hydrolyses ITP to IMP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32960", "l": "H2O + L-isoleucine + NAD(+) => (S)-3-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45387", "l": "H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433599", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392263", "l": "AVP(20-28) binds AVPR2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18585", "l": "D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate"}, {"i": "EC:5.3.1.1", "l": "\"Triose-phosphate isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55146", "l": "[4-(6-methylheptanoyl)-5-oxo-2H-furan-3-yl]methyl phosphate + H(+) + NADPH => [(3S,4R)-4-(6-methylheptanoyl)-5-oxooxolan-3-yl]methyl phosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103104", "l": "6-methylthiohexyldesulfoglucosinolate sulfotransferase activity"}, {"i": "MetaCyc:RXNQT-4331"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933538", "l": "Recruitment of IRF7 to TRAF6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692764", "l": "MAPK6 binds CCND3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14253", "l": "guanosine 3',5'-bis(diphosphate) + H2O = diphosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34443", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose = CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+)"}, {"i": "EC:2.3.1.210", "l": "\"dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57281", "l": "a guanosine in RNA + glyoxal => an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51947", "l": "8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine <=> 2 H(+) + roseoflavin + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0000179", "l": "rRNA (adenine-N6,N6-)-dimethyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177934", "l": "EGFR autophosphorylation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34294", "l": "2',4,4',6'-tetrahydroxychalcone + UDP-alpha-D-glucose <=> 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428273", "l": "SPHK1 phosphorylates SPG to S1P (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.27", "l": "\"RING-type E3 ubiquitin transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70481", "l": "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909732", "l": "Phosphorylation of STAT2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186773", "l": "PDGF dimer binds two receptors simultaneously (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49120", "l": "H(+) + NADPH + O2 + protoviolaceinate = H2O + NADP(+) + violaceinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956684", "l": "ITCH polyubiquitinates TP73 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9005980", "l": "IL21 binds IL21R:JAK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77068", "l": "Activation of GT (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10886", "l": "acetaldehyde + cholesta-5,24-dien-3beta-ol => (24R,24(1)R)-fucosterol epoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62713", "l": "betaenone C + H(+) + NADPH + O2 => H2O + NADP(+) + stemphyloxin I"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64779", "l": "3-sulfanylpentan-1-ol-L-cysteine <=> 2-aminoprop-2-enoate + 3-sulfanyl-1-pentanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013021", "l": "GDIs block activation of RHOB (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66701", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + ATP + CoA => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56147", "l": "a quinol + nitrate <=> a quinone + H2O + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37007", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709547", "l": "ESTG binds ESR2:chaperone complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003862", "l": "3-isopropylmalate dehydrogenase activity"}, {"i": "RHEA:32271", "l": "(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH"}, {"i": "EC:1.1.1.85", "l": "\"3-isopropylmalate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42795", "l": "cholesterol + hexadecanoyl-CoA <=> cholesteryl hexadecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21514", "l": "2-dehydro-3-deoxy-L-galactonate => 3,6-anhydro-L-galactonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9688832", "l": "MLKL binds PDCD6IP and SDCBP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34532", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose => CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982017", "l": "Active G alpha (q) binds RGS proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10860", "l": "3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2 = 2-(acetamidomethylene)succinate + NAD(+)"}, {"i": "RHEA:10864", "l": "3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2 = 2-(acetamidomethylene)succinate + NADP(+)"}, {"i": "EC:1.14.13.242", "l": "\"3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696465", "l": "USP45 deubiquitinates ERCC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1606312", "l": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17003", "l": "proclavaminate + urea => amidinoproclavaminate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016618", "l": "hydroxypyruvate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48038", "l": "globoside Gb3Cer (d18:1(4E)) + N-acetyl-beta-D-galactosamine => globoside Gb4Cer (d18:1(4E)) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9688459", "l": "RIPK3 binds HSP90:CDC37 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694428", "l": "LMAN family proteins bind glycosylated cargo (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20521", "l": "(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH"}, {"i": "EC:1.1.1.30", "l": "\"3-hydroxybutyrate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050423", "l": "thiamine oxidase activity"}, {"i": "RHEA:21280", "l": "H2O + 2 O2 + thiamine = H(+) + 2 H2O2 + thiamine acetate"}, {"i": "EC:1.1.3.23", "l": "\"Thiamine oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170120", "l": "Translocation of Cdc25B to the cytoplasm (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30630", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) <=> (2S)-2-acetolactate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684275", "l": "IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51104", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47681", "l": "D-galactosamine 6-phosphate + H2O => D-tagatose 1-phosphate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675896", "l": "PI(3,5)P2 transports from the early endosome membrane to the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29372", "l": "dAMP + H2O => 2'-deoxyadenosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940959", "l": "Neurolysin degrades neurotensin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67092", "l": "ATP + docosanoate(in) + H2O = ADP + docosanoate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2514790", "l": "Elastin degradation by MMP14 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24157", "l": "2-methylpropanoate + ATP => 2-methylpropanoyl phosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027631", "l": "5-HEDH dehydrogenates 7-HDHA to 7-oxo-DHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951676", "l": "RUNX3 binds TEADs and YAP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17975", "l": "5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine => diphosphate + IMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12168", "l": "allyl alcohol + NADP(+) = acrolein + H(+) + NADPH"}, {"i": "EC:1.1.1.54", "l": "\"Allyl-alcohol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53616", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-isoafricanol + diphosphate"}, {"i": "EC:4.2.3.157", "l": "\"(+)-isoafricanol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42236", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21637", "l": "(E)-4-coumarate + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-trans-4-coumarate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72631", "l": "Formation of the cap-binding eIF4F complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034216", "l": "high-affinity thiamine:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45544", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043546", "l": "molybdopterin cofactor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781897", "l": "USP11 deubiquitinates NFKBIA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052770", "l": "coenzyme F390-A hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59937", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49544", "l": "(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O = 2-dehydro-3-deoxy-D-gluconate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63579", "l": "ecdysone 22-phosphate + H2O <=> ecdysone + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186780", "l": "PI3-kinase binds to the active receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31577", "l": "8-oxo-dGMP + diphosphate + H(+) => 8-oxo-dGTP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13163", "l": "(2S)-2-amino-3-oxobutanoate + H(+) + NADH => L-threonine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37812", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070908", "l": "tyrosine:tyramine antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022141", "l": "Prolysyl oxidase activation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53858", "l": "3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH => NADP(+) + ursocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25653", "l": "(2S)-2-amino-3-oxobutanoate + H(+) = aminoacetone + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362437", "l": "C-terminal Hh fragments are bound by lectins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682769", "l": "LGI2 binds ADAM22,23 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35364", "l": "(2E)-13-methyltetradecenoyl-CoA + H(+) + NADPH => isopentadecanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061607", "l": "peptide alpha-N-propionyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202713", "l": "CD84 homodimerises (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66163", "l": "hexanoyl-CoA + tyramine <=> CoA + H(+) + N-hexanoyltyramine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48187", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44060", "l": "2-O-sulfo-alpha,alpha-trehalose + hexadecanoyl-CoA = 2-O-sulfo-2'-O-hexadecanoyl-alpha,alpha-trehalose + CoA"}, {"i": "RHEA:58048", "l": "2-O-sulfo-alpha,alpha-trehalose + octadecanoyl-CoA = 2-O-sulfo-2'-O-octadecanoyl-alpha,alpha-trehalose + CoA"}, {"i": "EC:2.3.1.288", "l": "\"2-O-sulfo trehalose long-chain-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416510", "l": "GRK5 sequesters activated Gq (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65687", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontadienoyl)-sphing-4-enine <=> a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontadienoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51487", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17266", "l": "trans-aconitate => cis-aconitate"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0042084", "l": "5-methyltetrahydrofolate-dependent methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042166", "l": "acetylcholine binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047068", "l": "N5,N10-methenyltetrahydromethanopterin hydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30443", "l": "2 glycyl-tRNA(Gly) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc = 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)"}, {"i": "EC:2.3.2.18", "l": "\"N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N(6)-triglycine)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14063", "l": "glycine + H(+) + NADH + pyruvate => H2O + N-(carboxymethyl)-D-alanine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50462", "l": "a medium-chain fatty acyl-[ACP] + AMP + diphosphate => a medium chain fatty acid + ATP + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610722", "l": "CK1 phosphorylates p-GLI3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.21"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983300", "l": "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624365", "l": "Expression of PLTP regulated by NR1H2 or NR1H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22791", "l": "dimethylsulfonioacetate + L-homocysteine <=> (methylsulfanyl)acetate + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19587", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADH => lithocholate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37651", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43467", "l": "H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59240", "l": "L-arginine + L-lysine = L-homoarginine + L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44668", "l": "4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol = 4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)"}, {"i": "EC:2.7.8.47", "l": "\"Teichoic acid ribitol-phosphate polymerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74726", "l": "Dissociation of insulin from insulin receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35286", "l": "(9Z)-octadecenoyl-CoA <=> (2E)-octadecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10074", "l": "glycine betaine + H(+) + S-adenosyl-L-homocysteine => N,N-dimethylglycine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59652", "l": "D-xylotetraono-1,5-lactone + H2O = D-xylotetraonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204871", "l": "Interaction of Tie2 and Grb2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51506", "l": "a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone + H(+) + UDP => a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61247", "l": "H2O + L-tryptophan + O2 <=> H2O2 + indole-3-pyruvate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83793", "l": "Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656250", "l": "Defective OGG1 mutants do not excise 8-oxoguanine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54699", "l": "4-hydroxybenzoate + ATP + holo-[4-hydroxyphenylalkanoate synthase] <=> 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22424", "l": "an S-alkyl-L-cysteine + H2O = an alkyl thiol + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637765", "l": "Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47370", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61163", "l": "quercetin + UDP-beta-L-rhamnose <=> H(+) + quercitrin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693347", "l": "CRYM reduces P2C to PPCA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.20", "l": "\"Cathepsin G\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641229", "l": "TLE oligomerizes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714481", "l": "RAC2 binds effectors at the ER membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205306", "l": "Interaction of SHP1 and KIT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682992", "l": "KDM4A,B bind H4K20Me2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210271", "l": "Interaction of DAP12 and MDL-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013159", "l": "CDC42 GEFs activate CDC42 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22083", "l": "H(+) + NADH + O2 + quinolin-2-ol <=> H2O + NAD(+) + quinoline-2,8-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200406", "l": "CPT1A,B transfers PALM to CAR (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204485", "l": "Basigin binds CyPA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43047", "l": "hexadecasphinganine + octadecanoyl-CoA <=> CoA + H(+) + N-octadecanoylhexadecasphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168140", "l": "Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391913", "l": "FPR2 binds FPR2 ligands (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31247", "l": "H(+) + prop-2-ynal + pyrroloquinoline quinol = prop-2-yn-1-ol + pyrroloquinoline quinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786190", "l": "CMBL hydrolyses OM to OLMS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23466", "l": "3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14297", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-galactose"}, {"i": "EC:3.2.1.46", "l": "\"Galactosylceramidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53027", "l": "a plastoquinone + H2O + L-arginine <=> 5-guanidino-2-oxopentanoate + a plastoquinol + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784598", "l": "NPPA(124-151) binds NPR1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41526", "l": "5 CO2 + 5 CoA + H2O + naphthalene-1,3,6,8-tetrol => 5 H(+) + 5 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654425", "l": "Activated FGFR4 binds SHC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641206", "l": "RSPOs bind LGRs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45365", "l": "H2O + N-(11Z-eicosenoyl)-(4R)-hydroxysphinganine => (11Z)-eicosenoate + (4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009815", "l": "1-aminocyclopropane-1-carboxylate oxidase activity"}, {"i": "MetaCyc:ETHYL-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060175", "l": "brain-derived neurotrophic factor-activated receptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047543", "l": "2-hexadecenal reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419166", "l": "GEFs activate RhoA,B,C (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50851", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31327", "l": "1D-myo-inositol 3-phosphate + CDP-1L-myo-inositol = bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate + CMP + H(+)"}, {"i": "EC:2.7.8.34", "l": "\"CDP-L-myo-inositol myo-inositolphosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59874", "l": "3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP => L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420202", "l": "Secretin receptor binds secretin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5263633", "l": "DYSF, CAV3 and TRIM72 bind (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60093", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) => 4alpha-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168880", "l": "vRNP Export through the nuclear pore (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53801", "l": "lithocholoyl-CoA + ursodeoxycholate => lithocholate + ursodeoxycholoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784189", "l": "JAKs bind LIFR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0003997", "l": "acyl-CoA oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.37"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097200", "l": "cysteine-type endopeptidase activity involved in execution phase of apoptosis"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5671772", "l": "p-T38-PPP1R14A binds MLCP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51477", "l": "a ribonucleoside 5'-triphosphate + formate + H(+) => a 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59362", "l": "beta-alanine + L-histidine => carnosine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13236", "l": "guanosine + phosphate <=> alpha-D-ribose 1-phosphate + guanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15109", "l": "2-dehydro-3-deoxy-D-gluconate + NADP(+) = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH"}, {"i": "EC:1.1.1.126", "l": "\"2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3095901", "l": "ABCC1 transports cytosolic Cbl to extracellular region (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004815", "l": "aspartate-tRNA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21579", "l": "carnitine + H(+) <=> 2-methylcholine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21231", "l": "alpha-maltose <=> beta-maltose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65470", "l": "CoA + propyl acetate => 1-propanol + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655170", "l": "RCHY1 monoubiquitinates POLH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73718", "l": "UBF-1 Binds rDNA Promoter (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018627", "l": "2-aminobenzenesulfonate 2,3-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033460", "l": "GAG codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222093", "l": "BRD7 binds TP53 and EP300 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862184", "l": "USP48 cleaves polyubiquitin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32098", "l": "acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose <=> CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60843", "l": "a 5'-end diphospho-adenosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] <=> a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45476", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52539", "l": "adenosine + dGTP <=> AMP + dGDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0009055", "l": "electron transfer activity"}, {"i": "REACT:R-HSA-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Homo sapiens)"}, {"i": "REACT:R-HSA-2564826", "l": "4Fe-4S cluster assembles on NUBP2:NUBP1 scaffold (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17927", "l": "H(+) + L-arabinono-1,4-lactone + NADH => L-arabinofuranose + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47199", "l": "a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44863", "l": "(R)-carnitine + 4,8-dimethylnonanoyl-CoA <=> CoA + O-4,8-dimethylnonanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17903", "l": "H(+) + S-adenosyl-L-homocysteine + xanthotoxin => S-adenosyl-L-methionine + xanthotoxol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15906", "l": "3-hydroxycyclohexanone + A => AH2 + cyclohexane-1,3-dione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60319", "l": "N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13481", "l": "ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)"}, {"i": "EC:6.1.1.10", "l": "\"Methionine--tRNA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604722", "l": "Activation of proMMP9 by proteases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36950", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.2.5", "l": "\"Phosphoglucomutase (glucose-cofactor)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27523", "l": "2,5-dihydroxypyridine + O2 => H(+) + N-formylmaleamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2509838", "l": "ITPA hydrolyses dITP to dIMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-996727", "l": "REST recruits the BHC complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33336", "l": "1,2-dioctadecanoyl-sn-glycero-3-phosphate + H2O => 1,2-dioctadecanoyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12379", "l": "ATP + L-fuculose <=> ADP + H(+) + L-fuculose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955885", "l": "SOCS3 gene expression is inhibited by RUNX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786789", "l": "FLT3LG dimer binds FLT3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-191303", "l": "FDPS dimer transfers IPPP to GPP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021951", "l": "OPRK1 gene expression is stimulated by MECP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952807", "l": "p-Y693-STAT4 dissociates after IL12:IL12R interaction (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60344", "l": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.361", "l": "\"[Histone H4]-lysine(20) N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928656", "l": "gamma-secretase cleaves EPHB2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28130", "l": "baicalin + H2O = baicalein + D-glucuronate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.17"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928580", "l": "SFKs phosphorylate EFNBs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52620", "l": "3-methylbutanoyl-CoA = 2,2-dimethylpropanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41700", "l": "1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + glutarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205112", "l": "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45238", "l": "(25R)-3beta-hydroxy-5-cholestenoate + H2O + 2 oxidized [adrenodoxin] => (25R)-3beta-hydroxy-5-cholesten-26-al + H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201669", "l": "Beta-catenin translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047500", "l": "(+)-borneol dehydrogenase activity"}, {"i": "RHEA:17329", "l": "(1R,2S,4R)-borneol + NAD(+) = (1R,4R)-camphor + H(+) + NADH"}, {"i": "EC:1.1.1.198", "l": "\"(+)-borneol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112037", "l": "Inactivation of PLC beta (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44376", "l": "a 1-acyl-sn-glycero-3-phosphocholine(in) = a 1-acyl-sn-glycero-3-phosphocholine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45959", "l": "(9Z)-octadecenoyl-CoA(in) <=> (9Z)-octadecenoyl-CoA(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10507", "l": "7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH + O2 <=> 7alpha,12alpha-dihydroxycholest-4-en-3-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18607", "l": "1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + H(+) => 1-amino-1-deoxy-scyllo-inositol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.5.-", "l": "\"With a quinone or related compound as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200396", "l": "Creatine transport across the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54847", "l": "H(+) + hexan-3-one + NADPH + O2 <=> ethyl butanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21748", "l": "(S)-lactaldehyde + NADP(+) = H(+) + methylglyoxal + NADPH"}, {"i": "EC:1.1.1.283", "l": "\"Methylglyoxal reductase (NADPH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9006844", "l": "IL21:IL21R:JAK1 binds IL2RG:JAK3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606789", "l": "ARSB hydrolyses DS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050095", "l": "methionine decarboxylase activity"}, {"i": "KEGG.REACTION:R00656"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203973", "l": "Vesicle budding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70475", "l": "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32979", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O = a fatty acid + H(+) + sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12566", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+) + NADH => 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781922", "l": "USP13 binds UFD1L:SKP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050693", "l": "LBD domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009541", "l": "ESR1 binds to TFF1 gene promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24867", "l": "4-O-deacetyl-16-O-demethylvindoline + CO2 + succinate => (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + 2-oxoglutarate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50824", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 = 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674398", "l": "D842V PDGFRA doesn't bind sunitinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23723", "l": "ATP + hydrogencarbonate + propanoyl-CoA <=> (S)-methylmalonyl-CoA + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43343", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] <=> [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29832", "l": "Ni(2+)(in) => Ni(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15284", "l": "5alpha-cholest-7-en-3beta-ol <=> 5alpha-cholest-8-en-3beta-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015104", "l": "antimonite transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53387", "l": "5,10-methylenetetrahydromethanopterin + NAD(+) <=> 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57263", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP <=> GDP + H(+) + lactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33650", "l": "(9Z)-hexadecenoate + ATP + CoA <=> (9Z)-hexadecenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59202", "l": "diphosphate + docosanoyl-AMP => ATP + docosanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60382", "l": "L-dehydroascorbate(in) => L-dehydroascorbate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18977", "l": "a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788999", "l": "HV1-mediated H+ transfer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004038", "l": "allantoinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798743", "l": "Exocytosis of secretory granule membrane proteins (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13212", "l": "A + 3 H2O + trithionate <=> AH2 + 4 H(+) + 3 sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29361", "l": "phosphate + uridine => H2O + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27457", "l": "3-iodo-L-tyrosine + iodide + NADP(+) = 3,5-diiodo-L-tyrosine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76386", "l": "CYP1A2 S-demethylates 6MMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38067", "l": "2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA = 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10650", "l": "6-hydroxyhexan-6-olide + H2O + NADP(+) => 2-hydroxycyclohexan-1-one + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429036", "l": "SLC2A9 transports Fru, Glc, urate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675417", "l": "PEBP1 binds activated RAF1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2160915", "l": "Receptor-mediated uptake of HA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66574", "l": "2-naphthyl sulfate + adenosine 3',5'-bisphosphate + H(+) => 2-naphthol + 3'-phosphoadenylyl sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17845", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH"}, {"i": "EC:1.1.1.193", "l": "\"5-amino-6-(5-phosphoribosylamino)uracil reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061928", "l": "glutathione specific gamma-glutamylcyclotransferase activity"}, {"i": "RHEA:47724", "l": "glutathione = 5-oxo-L-proline + L-cysteinylglycine"}, {"i": "EC:4.3.2.7", "l": "\"Glutathione-specific gamma-glutamylcyclotransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047493", "l": "ceramide cholinephosphotransferase activity"}, {"i": "RHEA:16273", "l": "an N-acylsphing-4-enine + CDP-choline = a sphingomyelin + CMP + H(+)"}, {"i": "EC:2.7.8.3", "l": "\"Ceramide cholinephosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868230", "l": "SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693593", "l": "D-loop extension by DNA polymerases (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852354", "l": "GTSE1 facilitates proteasome-mediated degradation of TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042410", "l": "6-carboxyhexanoate-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14475", "l": "a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH => a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901641", "l": "ITP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045484", "l": "L-lysine 6-transaminase activity"}, {"i": "RHEA:21200", "l": "2-oxoglutarate + L-lysine = (S)-2-amino-6-oxohexanoate + L-glutamate"}, {"i": "EC:2.6.1.36", "l": "\"L-lysine 6-transaminase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052761", "l": "exo-1,4-beta-D-glucosaminidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43663", "l": "ATP + hydrogencarbonate + propanoyl-CoA <=> ADP + H(+) + methylmalonyl-CoA + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017061", "l": "S-methyl-5-thioadenosine phosphorylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696146", "l": "AOC2 deaminates TYR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047306", "l": "D-methionine-pyruvate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008690", "l": "3-deoxy-manno-octulosonate cytidylyltransferase activity"}, {"i": "RHEA:23448", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate"}, {"i": "EC:2.7.7.38", "l": "\"3-deoxy-manno-octulosonate cytidylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16131", "l": "H(+) + NADPH + pyridoxal => NADP(+) + pyridoxine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27509", "l": "cocaine + H2O <=> benzoate + ecgonine methyl ester + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097008", "l": "(3E)-4,8-dimethyl-1,3,7-nonatriene synthase activity"}, {"i": "MetaCyc:RXN-8619"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-167427", "l": "Opioid dissociates from MOR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51279", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate <=> (9S)-hydroperoxy-(10E,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444433", "l": "Cho transports from the extracellular space to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55467", "l": "11-hydroxysugiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11,20-dihydroxysugiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48454", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetyl-beta-D-galactosamine => ganglioside GA2 (d18:1(4E)) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189406", "l": "4 PBGs bind to form HMB (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62409", "l": "3,3'-di-O-methyl-4alpha-mannobiose + S-adenosyl-L-methionine => 1,3,3'-tri-O-methyl-4alpha-mannobiose + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0003918", "l": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"}, {"i": "EC:5.6.2.2", "l": "\"DNA topoisomerase (ATP-hydrolyzing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39151", "l": "3-oxooctadecanoyl-CoA + H(+) + NADPH = (3R)-hydroxyoctadecanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5688294", "l": "SIRT5 deacetylates Cytochrome C (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047757", "l": "chondroitin-glucuronate 5-epimerase activity"}, {"i": "RHEA:21084", "l": "chondroitin 4'-sulfate = dermatan 4'-sulfate"}, {"i": "EC:5.1.3.19", "l": "\"Chondroitin-glucuronate 5-epimerase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047809", "l": "D-2-hydroxy-acid dehydrogenase activity"}, {"i": "KEGG.REACTION:R00297"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949301", "l": "RORC gene expression is stimulated by RUNX3:CBFB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433501", "l": "Interaction of other adapter proteins with p-KIT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446391", "l": "Formation of the PINCH-ILK-parvin complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38498", "l": "a triacylglycerol + H2O <=> a 1,3-diacylglycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665727", "l": "FMNL2 binds CDC42:GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61916", "l": "ATP + fluconazole(in) + H2O = ADP + fluconazole(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59539", "l": "ATP + butanoyl-CoA + hydrogencarbonate <=> (2R)-ethylmalonyl-CoA + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57377", "l": "(S)-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-1-hydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66072", "l": "4-methyl-2-oxopentanoate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55411", "l": "[phosphate](n) + CTP <=> [phosphate](n+1) + CDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17156", "l": "CDP-D-glucose <=> CDP-4-dehydro-6-deoxy-D-glucose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177491", "l": "Formation of clathrin-coated vesicle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029268", "l": "Phosphorylation and activation of PLCG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004523", "l": "RNA-DNA hybrid ribonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693608", "l": "Initial resection of double-strand break ends (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38098", "l": "gamma-tocotrienol + S-adenosyl-L-methionine <=> alpha-tocotrienol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43754", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein uS5] => acetyl-CoA + N-terminal L-alanyl-[ribosomal protein uS5]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40147", "l": "eicosanoyl-CoA + H2O = CoA + eicosanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32512", "l": "(4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O => (3R,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21214", "l": "4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate => H2O + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27707", "l": "ATP + D-alanine + D-serine => ADP + D-alanyl-D-serine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218812", "l": "FYN phosphorylates PAK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11188", "l": "3-cyano-L-alanine + 2 H2O = L-aspartate + NH4(+)"}, {"i": "EC:3.5.5.4", "l": "\"Cyanoalanine nitrilase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39120", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2 => (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13498", "l": "5-dehydro-2-deoxy-D-gluconate + ATP => 6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029272", "l": "Release of PLCG from FCGR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033736", "l": "L-lysine 6-oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30413", "l": "benzyl benzoate + CoA => benzoyl-CoA + benzyl alcohol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8857686", "l": "FITM1, FITM2 bind TAGs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627891", "l": "Defective SLC27A4 does not transport LCFAs from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28184", "l": "(1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate => (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23746", "l": "3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate => 2-oxoglutarate + L-histidinol phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211924", "l": "CYP4B1 12-hydroxylates ARA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66992", "l": "3-methylpentanoate + ATP + CoA = 3-methylpentanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27778", "l": "4-hydroxy-3-all-trans-octaprenylbenzoate + H(+) = 2-all-trans-octaprenylphenol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44075", "l": "1-O-alkyl-2-acyl-sn-glycerol + ATP <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52914", "l": "3-dimethylallyl-4-hydroxybenzoate + CO2 + H2O => 3-dimethylallyl-4-hydroxymandelate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39438", "l": "(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60309", "l": "L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine => 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1028817", "l": "CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804955", "l": "ATM phosphorylates MDM2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604731", "l": "Autocatalytic activation of MMP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8939204", "l": "ESTG binds ESR1:chaperone complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39017", "l": "docosanedioate + 2 H(+) + NADH => 22-oxodocosanoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37653", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56887", "l": "adenosine(32) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methyladenosine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36302", "l": "(E)-caffeate + ATP + CoA <=> (E)-caffeoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174491", "l": "Transport of trimeric ENV precursor to Golgi apparatus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59820", "l": "2 ATP = adenosine 3'-diphosphate,5'-triphosphate + AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51193", "l": "(R)-2-hydroxyglutarate + NADP(+) => 2-oxoglutarate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654510", "l": "FGFRL1 binds SPRED1/2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034038", "l": "deoxyhypusine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2468040", "l": "Cohesin binds PDS5 and WAPAL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57321", "l": "acetyl-CoA + N-terminal L-(Asp/Glu)3-[protein] => CoA + H(+) + N-terminal N-acetyl-L-(Asp/Glu)3-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707523", "l": "Hemes bind to BACH1:MAFK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46293", "l": "a 5'-end triphospho-(purine-ribonucleoside) in mRNA + GDP + H(+) => a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14590", "l": "luteolin + S-adenosyl-L-methionine => chrysoeriol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.246"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23390", "l": "7''-O-phosphohygromycin B + ADP + H(+) => ATP + hygromycin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218891", "l": "RIPK1:RIPK3 oligomer binds MLKL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876255", "l": "CBL recruits CIN85:endophilin complex to InlB-bound MET (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33164", "l": "beta-nicotinamide D-riboside(in) => beta-nicotinamide D-riboside(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63126", "l": "ethanolamine + octadecanoate => H2O + N-octadecanoyl ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61434", "l": "(6E)-8-oxogeranial + H(+) + NADPH => (R)-8-oxocitronellyl enol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2484822", "l": "Kinetochore assembly (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18834", "l": "4-formylbenzenesulfonate + H2O + NAD(+) => 4-sulfobenzoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047935", "l": "glucose 1-dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60775", "l": "2 2-oxoglutarate + gibberellin A12 + H(+) + 3 O2 <=> 3 CO2 + gibberellin A9 + 2 H2O + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49190", "l": "a 3-vinylbacteriochlorophyllide d + H2O => a bacteriochlorophyllide d"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50435", "l": "AH2 + prostaglandin G1 <=> A + H2O + prostaglandin H1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56298", "l": "pyruvate + S-sulfanyl-L-cysteinyl-[protein] => 2-oxo-3-sulfanylpropanoate + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102423", "l": "(+)-sesaminol 2-O-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-13818"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54797", "l": "a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP(+) => an (R)-2-alkyl-3-oxoalkanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31043", "l": "(S)-methylmalonate semialdehyde + H2O + NAD(+) = 2 H(+) + methylmalonate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39453", "l": "(2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O => (3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016213", "l": "linoleoyl-CoA desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202248", "l": "Phosphorylation of PLC-gamma1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41810", "l": "(2E)-butenoyl-[ACP] + H2O => (3R)-hydroxybutanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48691", "l": "H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine <=> D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33162", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67124", "l": "a hydroperoxide + L-cysteinyl-[protein] = an alcohol + S-hydroxy-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48957", "l": "[thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide => [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76456", "l": "O-atom dealkylation of dextromethorphan (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16393", "l": "H2O + juvenile hormone II = H(+) + juvenile hormone II carboxylate + methanol"}, {"i": "EC:3.1.1.59", "l": "\"Juvenile-hormone esterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217017", "l": "Deubiquitination of FancD2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26190", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP => 1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51121", "l": "(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 AH2 => (8S,15S)-dihydroxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47349", "l": "a butanoate ester + H2O => an aliphatic alcohol + butanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59289", "l": "beta-D-glucosyl-(1<->1)-sphing-4-enine + H2O => D-glucose + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19354", "l": "glycocholate + H2O => cholate + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5631941", "l": "SESN1,2,3 bind AMPK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016603", "l": "glutaminyl-peptide cyclotransferase activity"}, {"i": "RHEA:23652", "l": "N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)"}, {"i": "EC:2.3.2.5", "l": "\"Glutaminyl-peptide cyclotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928627", "l": "EPHB phosphorylates TIAM1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982645", "l": "GRKs bind ADRB2:Catecholamine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40497", "l": "N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine => N-[omega-(9Z,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904767", "l": "octanoic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-947499", "l": "Exchange of oxygen with sulfur in MoCo (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31534", "l": "2-oxoglutarate + L-arginine + O2 <=> CO2 + N(omega)-hydroxy-L-arginine + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54088", "l": "3,4-dihydroxyphenylacetate + H(+) + NADH + O2 = 2,4,5-trihydroxyphenylacetate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20027", "l": "gibberellin A3 O-beta-D-glucoside + H(+) + UDP => gibberellin A3 + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60708", "l": "(1R,3R)-chrysanthemal + H2O + NAD(+) = (1R,3R)-chrysanthemate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21539", "l": "(3S)-hydroxy-3-methylglutaryl-CoA <=> H2O + trans-3-methylglutaconyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912349", "l": "Fucosylation of Pre-NOTCH by POFUT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31742", "l": "a 4'-hydroxyisoflavone + S-adenosyl-L-methionine <=> a 4'-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40282", "l": "(R)-carnitine + dodecanoyl-CoA <=> CoA + O-dodecanoyl-R-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.134"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428510", "l": "ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2002440", "l": "Removal of fibrillar collagen C-propeptides (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047151", "l": "methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941312", "l": "ZCCHC6, ZCCHC11 are mRNA uridyltransferases (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9035227", "l": "TXN2 binds CysS248-MPST (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30489", "l": "(1E,2S)-2-methylbutanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-isoleucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34605", "l": "CoA + H(+) + N-acyl-15-methylhexadecasphinganine => 15-methylhexadecasphinganine + a fatty acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21011", "l": "diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+) <=> diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034806", "l": "benzo(a)pyrene 11,12-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58976", "l": "H2O + malonaldehyde + O2 = 3-oxopropanoate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64111", "l": "H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25314", "l": "glycolate + O2 <=> glyoxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209760", "l": "Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419645", "l": "Dimerization of LIMK1 by Hsp90 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45919", "l": "12-hydroxyoctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(13-hydroxy-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16621", "l": "dihydrosanguinarine + H(+) + O2 = H2O2 + sanguinarine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001227", "l": "quercitrin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2509838", "l": "ITPA hydrolyses dITP to dIMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2172666", "l": "RB1 binds condensin II (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23269", "l": "guanidinoacetate + H2O => glycine + urea"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0016262", "l": "protein N-acetylglucosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46694", "l": "4-hydroxybenzoyl-5'-AMP + diphosphate => 4-hydroxybenzoate + ATP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64946", "l": "dCMP + 2 H(+) + 2 phosphate => dCTP + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47802", "l": "an aromatic oxo-acid + L-methionine => 4-methylsulfanyl-2-oxobutanoate + an aromatic L-alpha-amino acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.99.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004778", "l": "succinyl-CoA hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33017", "l": "[(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + H2O + NADP(+) => [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54895", "l": "[LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide <=> [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28798", "l": "2 a Fe(II)-siderophore + H(+) + NADP(+) <=> 2 a Fe(III)-siderophore + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22063", "l": "(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "70.373142106726959", "identifiers": [{"i": "GO:0033218", "l": "amide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2529020", "l": "CK2 phosphorylates condensin I subunits (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44692", "l": "a fatty acyl-CoA + hexadecasphinganine = CoA + H(+) + N-acylhexadecasphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10075", "l": "N,N-dimethylglycine + S-adenosyl-L-methionine <=> glycine betaine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59369", "l": "1-octadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O => 1-octadecanoyl-sn-glycero-3-phosphoserine + 10-hydroxyoctadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299475", "l": "TIMM23 PAM translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28733", "l": "H(+)(in) + L-leucine(out) => H(+)(out) + L-leucine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36881", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + A + 2 H2O => (8Z,11Z,14Z)-eicosatrienoyl-CoA + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800794", "l": "PIDD1 associates with CRADD (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660557", "l": "RAS:GTP binds RAL GDS proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848596", "l": "PTK6 binds PXN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249378", "l": "STING recruits TBK1 and STAT6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1253343", "l": "WWOX binds ERBB4s80 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42857", "l": "1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O => 1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5221061", "l": "TDG excises 5-carboxylcytosine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15178", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O => a fatty acid + H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3209165", "l": "ID1 sequesters ETS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39925", "l": "1-O-octadecyl-sn-glycerol + H(+) + phosphocholine => 1-O-octadecyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56846", "l": "nocamycin I + S-adenosyl-L-homocysteine => nocamycin E + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46452", "l": "2 L-leucyl-tRNA(Leu) = cyclo(L-leucyl-L-leucyl) + 2 H(+) + 2 tRNA(Leu)"}, {"i": "EC:2.3.2.22", "l": "\"Cyclo(L-leucyl-L-leucyl) synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66670", "l": "4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5-methylorsellinate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53682", "l": "2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46437", "l": "(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta,4beta-dihydroxycholest-5-en-26-oate + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610726", "l": "The IFT-A complex recruits TULP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27812", "l": "(2Z,6Z)-farnesyl diphosphate + 2 diphosphate => dimethylallyl diphosphate + 2 isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53727", "l": "ATP + N-acetyl-D-glucosamine <=> ADP + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190265", "l": "FGFR4 binds to FGF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33232", "l": "H2O2 + heme b => heme d cis-diol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015124", "l": "allantoate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862280", "l": "FCHo proteins bind nascent clathrin-coated pit (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-141437", "l": "Formation of the MCC complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54754", "l": "dihydromethanophenazine + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) => methanophenazine + reduced coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416562", "l": "p190RhoGAP binds Plexin-B1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45192", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420977", "l": "Ca permeable AMPA receptor ligand binding (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450387", "l": "HuR binds the CRM1 nuclear export machinery (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61046", "l": "(-)-(R)-19-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12446", "l": "(2E)-hexadecenal + H(+) + NADPH => hexadecanal + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001065", "l": "mitochondrial single subunit type RNA polymerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44218", "l": "12-hydroxyoctadecanoyl-CoA + AMP + diphosphate => 12-hydroxyoctadecanoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799466", "l": "TP53I3 dimerizes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950387", "l": "CANX binds EBI3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33681", "l": "2 [Fe(III)-cytochrome b5] + H2O + N-tetracosanoyl-(4R)-hydroxysphinganine => 2 [Fe(II)-cytochrome b5] + 2 H(+) + N-tetracosanoylsphinganine + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003830", "l": "beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity"}, {"i": "RHEA:15509", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}, {"i": "EC:2.4.1.144", "l": "\"Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428918", "l": "Dissociation of the TP:G13 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694583", "l": "ABHD4 hydrolyses NAPE (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005452", "l": "inorganic anion exchanger activity"}, {"i": "REACT:R-HSA-5656248", "l": "Defective SLC4A1 does not exchange Cl- for HCO3- (in erythrocytes) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15700", "l": "liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + licodione + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174660", "l": "nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694689", "l": "Fusion and Release of SARS-CoV-2 Nucleocapsid (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2995330", "l": "COX10 transforms heme to heme O (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19721", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}, {"i": "EC:1.14.19.1", "l": "\"Stearoyl-CoA 9-desaturase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047637", "l": "alanylphosphatidylglycerol synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171288", "l": "Cleavage of the viral Env gp160 precursor polyprotein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938228", "l": "RUNX1:CBFB:CREBBP binds the CSF2 (GM-CSF) gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35071", "l": "4-methylphenol(in) = 4-methylphenol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15180", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O <=> a fatty acid + H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53985", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56355", "l": "4-hydroxybenzoate + bromide + 2 H(+) + NADPH + O2 <=> 3-bromo-4-hydroxybenzoate + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9710354", "l": "GSDME (1-270) binds cardiolipin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58972", "l": "H2O + O2 + vanillin = 4-hydroxy-3-methoxybenzoate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062239", "l": "heterochromatin-nuclear membrane anchor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49986", "l": "(1R,2R)-12-hydroxyjasmonate + H2O + NADP(+) => H(+) + jasmonate + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209903", "l": "Noradrenaline is converted to adrenaline (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35582", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-[6-O-(4-O-beta-D-glucosyl-p-coumaroyl)-2-O-(beta-D-xylosyl)-beta-D-glucosyl]-5-O-(6-O-malonyl-beta-D-glucoside) <=> cyanidin 3-O-[6-O-(4-O-beta-D-glucosyl-p-coumaroyl)-2-O-(2-O-sinapoyl-beta-D-xylosyl)-beta-D-glucosyl]-5-O-(6-O-malonyl-beta-D-glucoside) + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39270", "l": "(15Z)-3-oxotetracosenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(15Z)-tetracosenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21999", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + an acyl-CoA <=> a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69756", "l": "Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52493", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2533970", "l": "NID1 degradation by MMP3, 7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162657", "l": "Inactivation of Myt1 kinase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10574", "l": "(2E)-butenoyl-CoA => vinylacetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58923", "l": "(3S,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol <=> (+)-medicarpin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37645", "l": "1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30309", "l": "formaldehyde + H2O + NADP(+) + xanthine => 7-methylxanthine + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626938", "l": "Beta-catenin binds SOX proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34156", "l": "acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine => CoA + H(+) + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40721", "l": "an S-substituted glutathione + cob(I)alamin--[alkylcobalamin reductase] + H(+) => an alkylcob(III)alamin + apo--[alkylcobalamin reductase] + glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676595", "l": "TRAFs bind RANK:RANKL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046975", "l": "histone methyltransferase activity (H3-K36 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45784", "l": "2 H2O + phenylpropanonitrile = 3-phenylpropanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62747", "l": "H2O + mevastatin <=> (S)-2-methylbutanoate + compactin diol lactone + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798044", "l": "BTG2 binds CCR4-NOT complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66509", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442387", "l": "ZIP8 mediates zinc influx into cells (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.22"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080089", "l": "sinapoyl spermidine:sinapoyl CoA N-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59008", "l": "H2O + O2 + salicylaldehyde = H(+) + H2O2 + salicylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38162", "l": "(2S,3S)-hydroxyarginine <=> (2S,3R)-capreomycidine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54907", "l": "(2E,9Z)-hexadecadienoyl-[ACP] + H(+) + NADH <=> (9Z)-hexadecenoyl-[ACP] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624954", "l": "INPP5E translocates to the primary cilium (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218804", "l": "p38 MAPK activation by VEGFR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34648", "l": "S-adenosyl-L-methionine + squalene => 3-methyl-1,2-didehydro-2,3-dihydrosqualene + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33170", "l": "2 a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycero-3-phospho-1D-myo-inositol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003726", "l": "double-stranded RNA adenosine deaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854738", "l": "CSF3 dimer:CSFR binds CSFR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44862", "l": "CoA + O-4,8-dimethylnonanoyl-(R)-carnitine => (R)-carnitine + 4,8-dimethylnonanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59059", "l": "2 methanethiol + NAD(+) <=> dimethyl disulfide + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24443", "l": "ATP + H2O + phosphate(out) <=> ADP + H(+) + 2 phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66772", "l": "ATP + H2O + uroporphyrin I(in) = ADP + H(+) + phosphate + uroporphyrin I(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40877", "l": "(2E,9Z,12Z)-octadecatrienoyl-CoA + FADH2 => (9Z,12Z)-octadecadienoyl-CoA + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75146", "l": "TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781905", "l": "ZRANB1 binds APC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008843", "l": "endochitinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60250", "l": "AH2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] => A + H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37985", "l": "2,3-dimethyl-6-phytylbenzene-1,4-diol => gamma-tocopherol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32497", "l": "(6E)-8-hydroxygeraniol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2E)-geraniol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043430", "l": "2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20628", "l": "2 [Fe(III)-cytochrome c3] + H2 <=> 2 [Fe(II)-cytochrome c3] + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173754", "l": "Properdin stabilizes C3b:Bb bound to cell surfaces (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34534", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose <=> CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17619", "l": "glutathione + leukotriene A4 => leukotriene C4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20769", "l": "3-phosphonopyruvate + H(+) => CO2 + phosphonoacetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18636", "l": "2 ATP + H2O + hydrogencarbonate + L-glutamine <=> 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031721", "l": "hemoglobin alpha binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956025", "l": "AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41967", "l": "butanoyl-CoA + O2 <=> (2E)-butenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64645", "l": "butan-1-ol + propanoyl-CoA => butyl propanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22674", "l": "diphosphate + presqualene diphosphate => 2 (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424476", "l": "Activation of RAC1 by VAV2/3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634446", "l": "GFI1 gene expression is enhanced by CEBPA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051742", "l": "2-methyl-6-solanyl-1,4-benzoquinone methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803890", "l": "SFN dimerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46284", "l": "2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 = (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033873", "l": "petromyzonol sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.-", "l": "\"Metalloendopeptidases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693111", "l": "RHOF auto-activates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63235", "l": "(2E)-octenoyl-CoA + H(+) + NADH <=> NAD(+) + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30836", "l": "H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => NADP(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64548", "l": "N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] = (3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.97"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33307", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein] = (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein]"}, {"i": "EC:2.7.1.195", "l": "\"Protein-N(pi)-phosphohistidine--2-O-alpha-mannosyl-D-glycerate phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793955", "l": "Defective MGAT2 does not transfer GlcNAc to N-glycans (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592314", "l": "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109701", "l": "PDPK1 binds PIP3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65205", "l": "(3R)-3-hydroxybutanoyl-CoA + H2O => (R)-3-hydroxybutanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192325", "l": "25(R) THCA-CoA is translocated from the cytosol to the peroxisome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16645", "l": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate"}, {"i": "EC:3.1.2.2", "l": "\"Palmitoyl-CoA hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27641", "l": "phosphate + xanthosine <=> alpha-D-ribose 1-phosphate + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50953", "l": "7-chloro-L-tryptophan + AH2 + O2 => A + CO2 + 2 H2O + monodechloroaminopyrrolnitrin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102285", "l": "1-deoxy-11-oxopentalenate oxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39359", "l": "(13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5444516", "l": "Formation of MSH2:MSH6 Complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30950", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> 10-epi-gamma-eudesmol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102104", "l": "demethoxycurcumin synthase activity"}, {"i": "MetaCyc:RXN-11224"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201608", "l": "Caspase-mediated cleavage of alpha adducin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61868", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31952", "l": "9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16199", "l": "acetoacetyl-CoA + H(+) + NADPH => (3S)-3-hydroxybutanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158340", "l": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14453", "l": "4-(phosphooxy)-L-threonine + NAD(+) = (2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57665", "l": "(+)-valencene + O2 + reduced [NADPH--hemoprotein reductase] => alpha-nootkatol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0016892", "l": "endoribonuclease activity, producing 3'-phosphomonoesters"}, {"i": "EC:3.1.27.-", "l": "\"Endoribonucleases producing other than 5'-phosphomonoesters\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34651", "l": "3-methyl-1,2-didehydro-2,3-dihydrosqualene + S-adenosyl-L-methionine = 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-741386", "l": "RIP2 induces K63-linked ubiquitination of NEMO (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38081", "l": "1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55210", "l": "(2R)-hydroxyhexadecanal + phosphoethanolamine => (4R)-hydroxysphinganine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854303", "l": "TBC1D11 binds RAB6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20565", "l": "(2E)-geranyl diphosphate + H2O = (1S,2S,4R)-endo-fenchol + diphosphate"}, {"i": "EC:4.2.3.10", "l": "\"(-)-endo-fenchol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112727", "l": "Serine phosphorylation of STATs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73718", "l": "UBF-1 Binds rDNA Promoter (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20409", "l": "alpha-D-glucose 1-phosphate + riboflavin = D-glucose + FMN"}, {"i": "EC:2.7.1.42", "l": "\"Riboflavin phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10721", "l": "2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O => 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164507", "l": "CD4:gp120  binds to chemokine co-receptor CCR5/CXCR4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12848", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O <=> [L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161794", "l": "Arachidonic acid is converted to HXA3/B3 by ALOX12 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19850", "l": "H2O + NADP(+) => ADP-D-ribose 2'-phosphate + H(+) + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58103", "l": "1-(15Z-tetracosenoyl)-glycerol + H2O <=> (15Z)-tetracosenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9617927", "l": "FOXO4 binds ATXN3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37649", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28751", "l": "sn-glycerol 3-phosphate + ubiquinone-8 = dihydroxyacetone phosphate + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13728", "l": "acetyl-CoA + alpha-D-glucosamine 1-phosphate <=> CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62274", "l": "8 AMP + bassianolide + 8 diphosphate + 8 H(+) + 4 S-adenosyl-L-homocysteine => 4 (R)-2-hydroxy-3-methylbutyrate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781922", "l": "USP13 binds UFD1L:SKP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49081", "l": "dibenzothiophene 5-oxide + FMNH2 + O2 => dibenzothiophene 5,5-dioxide + FMN + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53931", "l": "a tertiary amine + S-adenosyl-L-methionine <=> a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9617927", "l": "FOXO4 binds ATXN3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12145", "l": "cyanidin 3-O-rutinoside + UDP-alpha-D-glucose => cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635666", "l": "esxG:esxH translocates from MTb cytosol to host phagosomal lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39634", "l": "(2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H(+) + NADPH <=> (16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65699", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine <=> a diacylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39637", "l": "(3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+) => 3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64723", "l": "H(+)(out) + pyruvate(out) <=> H(+)(in) + pyruvate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2129362", "l": "Fibrillin microfibril assembly (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187506", "l": "Translocation of p27 to the nucleoplasm (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35074", "l": "4-methylphenol(in) <=> 4-methylphenol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6805061", "l": "CK2 binds FACT (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30350", "l": "ATP + IDP <=> ADP + ITP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604642", "l": "Proteasome degrades ubiquitinated NICD4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867613", "l": "PICALM binds R-SNAREs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46586", "l": "1alpha,25-dihydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1alpha-hydroxyvitamin D2 + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-398185", "l": "LARG binds plexin B1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247840", "l": "WLS binds WNT ligands in the Golgi (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1067640", "l": "IL6 binds IL6R-2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428625", "l": "Vesicular inhibitory amino acid transport (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41126", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11102", "l": "2 propanal => 4-hydroxyhexan-3-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592316", "l": "Initial activation of proMMP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017108", "l": "5'-flap endonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666129", "l": "CDC42:GTP recruits DIAPH2-2 to kinetochores (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46283", "l": "2 [Fe(II)-cytochrome b5] + an N-acylsphing-4-enine + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13489", "l": "(S)-canadine + H(+) + 2 O2 = berberine + 2 H2O2"}, {"i": "EC:1.3.3.8", "l": "\"Tetrahydroberberine oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22874", "l": "CO2 + succinate + trans-3-hydroxy-L-prolyl-[collagen] => 2-oxoglutarate + L-prolyl-[collagen] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29439", "l": "Fe(2+)(in) + H(+)(out) = Fe(2+)(out) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714691", "l": "RAC3 binds ER effectors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53472", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38715", "l": "ATP + choline(out) + H2O = ADP + choline(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39510", "l": "3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47966", "l": "L-histidyl-[protein] + phosphate => H2O + N(pros)-phospho-L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622668", "l": "FOXO3,(FOXO1) bind BBC3 gene first intron (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43552", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858346", "l": "AMHR2 binds AMH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621367", "l": "CLEC4A binds HIV and HCV glycoproteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56736", "l": "H2O + O2 + retinal = H(+) + H2O2 + retinoate"}]}
{"type": "biolink:MolecularActivity", "ic": "69.63974591466652", "identifiers": [{"i": "GO:0043565", "l": "sequence-specific DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2509838", "l": "ITPA hydrolyses dITP to dIMP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602466", "l": "Activation of MT-MMPs by FURIN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21629", "l": "17alpha-hydroxyprogesterone + NADPH + O2 => acetate + androst-4-ene-3,17-dione + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34674", "l": "3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + S-adenosyl-L-methionine <=> 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63326", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1,2-dihexadecanoyl-sn-glycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50779", "l": "hexanal + NADP(+) <=> (E)-hex--2-enal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-877187", "l": "P2X7 mediates loss of intracellular K+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47890", "l": "GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162715", "l": "Reorientation of dolichyl phosphate D-mannose in the endoplasmic reticulum membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65712", "l": "alpha-D-glucose 1-phosphate + GDP-beta-L-galactose = beta-L-galactose 1-phosphate + GDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56556", "l": "(2E,6E)-farnesyl diphosphate = delta-cadinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035005", "l": "1-phosphatidylinositol-4-phosphate 3-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031808", "l": "H2 histamine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68688", "l": "CDC6 association with ORC:origin complexes mediated by MCM8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874685", "l": "CBL binds MET (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83650", "l": "FasL:Fas binds FADD (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21421", "l": "NADP(+) + prostaglandin I2 => 15-dehydro-prostaglandin I2 + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66213", "l": "asc-omegaC5-CoA + O2 => asc-omegaDeltaC5-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61852", "l": "campesterol + UDP-alpha-D-glucose = campesteryl 3-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57720", "l": "ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate"}, {"i": "EC:7.1.2.2", "l": "\"H(+)-transporting two-sector ATPase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30376", "l": "(2E,6E)-farnesyl diphosphate => (+)-thujopsene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990757", "l": "ubiquitin ligase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66184", "l": "3',5'-cyclic AMP(in) + ATP + H2O = 3',5'-cyclic AMP(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23665", "l": "A + a (2R)-2-hydroxycarboxylate => a 2-oxocarboxylate + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11891", "l": "an aldehyde + H2O + NADP(+) <=> a carboxylate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22038", "l": "[phosphate](n-1) + D-glucose 6-phosphate + H(+) => [phosphate](n) + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29885", "l": "ADP + H(+) + L-ornithine(in) + phosphate => ATP + H2O + L-ornithine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0005499", "l": "vitamin D binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25395", "l": "(9Z,12Z)-octadecadienoate + O2 = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate"}, {"i": "EC:1.13.11.60", "l": "\"Linoleate 8R-lipoxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052719", "l": "apurinic/apyrimidinic endoribonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102307", "l": "erythromycin C 3''-o-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668398", "l": "CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676599", "l": "sBAFF trimer binds BAFFR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102155", "l": "S-sulfolactate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390641", "l": "ADRA1A,B,D bind ADR,NAd (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42150", "l": "a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acyl-(4R)-4-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944261", "l": "Association of procollagen type XIII (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41255", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49679", "l": "H(+) + L-methionyl(47)-[F-actin] + NADPH + O2 <=> H2O + L-methionyl(47)-(R)-S-oxide-[F-actin] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031843", "l": "type 2 neuropeptide Y receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-164832", "l": "ATPase synthesizes ATP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32042", "l": "H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate <=> AMP + ATP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64100", "l": "2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + TAN-1612"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050473", "l": "arachidonate 15-lipoxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48809", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.43"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15394", "l": "(2S,6S)-2,6-diaminoheptanedioate => meso-2,6-diaminoheptanedioate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004081", "l": "bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"}, {"i": "REACT:R-HSA-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44394", "l": "1-heptadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA => 1-heptadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781897", "l": "USP11 deubiquitinates NFKBIA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047337", "l": "dolichyl-diphosphate-polyphosphate phosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24282", "l": "2 H(+) + 2 S-adenosyl-L-homocysteine + syringetin => myricetin + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31584", "l": "2-hydroxy-dATP + H2O => 2-hydroxy-dAMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675194", "l": "Activated MAPK phosphorylates RAF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450488", "l": "BRF1 Complex recruits RNA degradation activities (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709317", "l": "CO binds to free ferrohemoglobin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396337", "l": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167566", "l": "Nef mediated disruption of CD4:Lck Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800793", "l": "PIDD1 translocates to the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2471621", "l": "Endostatin degradation by cathepsins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39922", "l": "1-O-(alk-1-enyl)-sn-glycero-3-phosphate + H2O <=> 1-O-(alk-1-enyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3132753", "l": "Pancreatic proteases degrade TCN1:Cbl (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46739", "l": "H2O + monoacyl-sn-glycero-3-phosphate <=> a monoacylglycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13218", "l": "H2O + NAD(+) + succinate semialdehyde => 2 H(+) + NADH + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30977", "l": "5 AH2 + all-trans-3,4-didehydrolycopene => 15-cis-phytoene + 5 A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.124"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6800490", "l": "ATM phosphorylates PIDD1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670433", "l": "KIT mutants:PI3K catalyze synthesis of PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41795", "l": "holo-[ACP] + malonyl-CoA <=> CoA + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60900", "l": "a cytidine in RNA + S-adenosyl-L-methionine = an N(3)-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45871", "l": "9-decenoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(non-8-en-1-yl)-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605736", "l": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5444516", "l": "Formation of MSH2:MSH6 Complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564112", "l": "Collagen type VI degradation by MMP2,9,11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41063", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008928", "l": "IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616214", "l": "RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, and MYB bind the CEBPA promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27966", "l": "7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate"}, {"i": "EC:4.1.2.50", "l": "\"6-carboxytetrahydropterin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130731", "l": "Formation of COPII vesicle (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57824", "l": "dAMP + H2O = 2-deoxy-D-ribose 5-phosphate + adenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13908", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine <=> a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788622", "l": "p-Y-STATs dimerize (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617207", "l": "SPI1 (PU.1), CEBPA and DEK bind the promoter of the CSF3R (G-CSFR) gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5227009", "l": "ABCF1 binds EIF2 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16278", "l": "H2O + indole-3-acetaldehyde + O2 => (indol-3-yl)acetate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55871", "l": "(S)-lactate + O2 <=> H2O2 + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.87", "l": "\"Endo-cleaving rubber dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0061542", "l": "3-demethylubiquinol-n 3-O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707586", "l": "FeHM oxidises LDL,HDL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8957389", "l": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34708", "l": "AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine => 5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40355", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + ATP = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.33"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047666", "l": "ammonia kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8938815", "l": "RNF152 polyubiquitinates RRAGA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63086", "l": "FAD + H(+) + 2 H2O + ilicicolin A => chloride + FADH2 + ilicicolin B + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708457", "l": "HM13 cleaves HMOX1 dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57655", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 <=> CMP + ganglioside GM1alpha + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592436", "l": "Initial activation of proMMP9 by MMPs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48269", "l": "4',4'-dihydroxyechinenone => canthaxanthin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74733", "l": "Insulin receptor de-phosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48972", "l": "ATP + H2O + phosphite(out) = ADP + H(+) + phosphate + phosphite(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1638845", "l": "CERK phosphorylates CERA to form C1P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44053", "l": "alpha,alpha-trehalose + hexadecanoyl-CoA => 2-O-hexadecanoyl-alpha,alpha-trehalose + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112342", "l": "Inactivation of MAP2K1 by CDK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39441", "l": "(2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H2O => (3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35459", "l": "cholesterol + NAD(+) = cholest-5-en-3-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18850", "l": "a 2'-unsubstituted isoflavone + O2 + reduced [NADPH--hemoprotein reductase] => a 2'-hydroxyisoflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990308", "l": "type-I dockerin domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694553", "l": "Recruitment of Spike trimer to assembling virion (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61928", "l": "(R)-miconazole(in) + ATP + H2O = (R)-miconazole(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37855", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA = 1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56305", "l": "ATP + H2O + rifampicin => 21-phosphorifampicin + AMP + 2 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228578", "l": "tetX LC cleaves target cell VAMP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2172433", "l": "Collagen type XIX degradation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209973", "l": "Tyrosine is diiodinated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814132", "l": "GDPD5 hydrolyzes GPCho (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39972", "l": "1-aminocyclopropane-1-carboxylate => 2-aminobut-2-enoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31252", "l": "(S)-3-hydroxyisobutanoyl-CoA + H2O => (S)-3-hydroxy-2-methylpropanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30803", "l": "4-aminobutanal + H2O + NADP(+) = 4-aminobutanoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193665", "l": "MYD88 dissociates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25230", "l": "L-arabinitol + NADP(+) => H(+) + L-arabinose + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30677", "l": "H2O + squalene => tetrahymanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848596", "l": "PTK6 binds PXN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427514", "l": "eNoSC deacetylates histone H3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43739", "l": "adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952232", "l": "BCL2L11 (BIM) gene transcription is stimulated by RUNX3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-868608", "l": "Trehalose-6-phosphate is hydrolyzed to trehalose (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31006", "l": "(S)-2,3-epoxysqualene <=> germanicol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11865", "l": "H(+) + H2O + oxidized [electron-transfer flavoprotein] + trimethylamine => dimethylamine + formaldehyde + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20518", "l": "UDP-N-acetyl-alpha-D-glucosamine => UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62025", "l": "campesteryl 3-beta-D-glucoside + H2O => campesterol + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15487", "l": "cis-homoaconitate + H2O => (1R,2S)-homoisocitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15107", "l": "H(+) + kaempferide + S-adenosyl-L-homocysteine => kaempferol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-481044", "l": "Surface deployment of platelet alpha granule membrane components (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10297", "l": "D-glyceraldehyde 3-phosphate + NADP(+) + phosphate => (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66735", "l": "ATP + H2O + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(in) <=> ADP + H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39507", "l": "3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015375", "l": "glycine:sodium symporter activity"}, {"i": "REACT:R-HSA-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)"}, {"i": "REACT:R-HSA-5660840", "l": "Defective SLC6A5 does not cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41229", "l": "4-hydroxyphenylglyoxylate + H2O2 => (S)-4-hydroxymandelate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40169", "l": "(2E)-hexadecenoyl-CoA + H2O2 => hexadecanoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18139", "l": "5alpha-pregnane-3,20-dione + H(+) + NADPH => 3beta-hydroxy-5alpha-pregnane-20-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65752", "l": "2-oxoglutarate + L-glutamate + O2 = (3R)-3-hydroxy-L-glutamate + CO2 + succinate"}, {"i": "EC:1.14.11.76", "l": "\"L-glutamate 3(R)-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12386", "l": "H2O2 + uracil => 5,6-dihydrouracil + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166753", "l": "Conversion of C4 into C4a and C4b (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010356", "l": "homogentisate geranylgeranyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854209", "l": "TBC1D10A binds JFC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46894", "l": "3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + L-glutamate => 2-oxoglutarate + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51670", "l": "H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pravastatin lactone => 2 H(+) + mevastatin + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5138432", "l": "DVL2 is phosphorylated by PKC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211960", "l": "CYP2U1 19-hydroxylates ARA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928578", "l": "EPH receptors autophosphorylate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451466", "l": "TRAF6 binding to activated IRAK2 stimulates its oligomerization (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195275", "l": "Phosphorylation of APC component of the destruction complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30282", "l": "2 H2 + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 3 H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59979", "l": "2-phenylacetate + H(+) <=> CO2 + toluene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.56"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034795", "l": "cyclohexane monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700168", "l": "Active ALK phosphorylates IRS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.162", "l": "\"Aldose beta-D-fructosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610757", "l": "GLI2 is degraded by the proteasome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483219", "l": "PC is exchanged with PI by PITPNB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59015", "l": "cycloartenol + S-adenosyl-L-methionine <=> 24-methylenecycloartanol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048040", "l": "UDP-glucuronate decarboxylase activity"}, {"i": "MetaCyc:UDP-GLUCURONATE-DECARBOXYLASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944261", "l": "Association of procollagen type XIII (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050465", "l": "nitroquinoline-N-oxide reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22576", "l": "an N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine + H(+)"}, {"i": "EC:3.1.1.81", "l": "\"Quorum-quenching N-acyl-homoserine lactonase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30053", "l": "fluoride + glycolate + H(+) => fluoroacetate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023617", "l": "Butyrylcholinesterase hydrolyzes acyl Ghrelin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.1.1.-", "l": "\"Hydron translocation or charge separation linked to oxidoreductase reactions\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937075", "l": "Phosphorylated TAK1 leaves activated TLR receptor complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54670", "l": "alpha-onocerin => pre-alpha-onocerin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61238", "l": "4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+) => H2O + L-methionine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46658", "l": "5beta-androstane-3,17-dione + NADP(+) => androst-4-ene-3,17-dione + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40363", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102752", "l": "1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373716", "l": "DCC interacting NCK-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42743", "l": "guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12198", "l": "acetyl phosphate + D-erythrose 4-phosphate + H2O => keto-D-fructose 6-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68603", "l": "ORC5 binds ORC2:ORC3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18846", "l": "(R)-glycerate + NAD(+) => 2-hydroxy-3-oxopropanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56695", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 <=> 4-[(E)-2-isocyanoethenyl]phenol + 2 CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53344", "l": "5,6-dihydrouridine(20a) in tRNA + NADP(+) = H(+) + NADPH + uridine(20a) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16319", "l": "H(+) + indan-1-one + NADH => (S)-indan-1-ol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19170", "l": "L-serine => NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10516", "l": "(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) = (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH"}, {"i": "EC:1.1.1.166", "l": "\"Hydroxycyclohexanecarboxylate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3857336", "l": "CEBPB homodimerization (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22133", "l": "ATP + D-maltose(out) + H2O => ADP + D-maltose(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23783", "l": "H2O + oxaloacetate + propanoyl-CoA <=> (2S,3S)-2-methylcitrate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61196", "l": "(E)-feruloyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] = CoA + H(+) + myricetin 3-O-[(6-O-[(E)-feruloyl]-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47455", "l": "(2E,5Z)-tetradecadienoyl-CoA + H2O <=> (3S)-hydroxy-(5Z-tetradecenoyl)-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17821", "l": "hydrogen cyanide + L-cysteine = 3-cyano-L-alanine + H(+) + hydrogen sulfide"}, {"i": "EC:4.4.1.9", "l": "\"L-3-cyanoalanine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20414", "l": "glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine => glucuronoxylan 4-O-methyl-D-glucuronate + n H(+) + n S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36129", "l": "O-methyl gibberellin A34 + S-adenosyl-L-homocysteine => gibberellin A34 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20137", "l": "10-deacetylbaccatin III + acetyl-CoA = baccatin III + CoA"}, {"i": "EC:2.3.1.167", "l": "\"10-deacetylbaccatin III 10-O-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12717", "l": "1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)"}, {"i": "EC:2.7.1.140", "l": "\"Inositol-tetrakisphosphate 5-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940561", "l": "MMP7 cleaves OPTC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665696", "l": "ERBB2 TMD/JMD mutants bind trastuzumab (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034862", "l": "2,6-dihydroxybenzothiazole monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371537", "l": "DBC1 binds SIRT1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948226", "l": "Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46953", "l": "2 formate + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 CO2 + H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604732", "l": "Autocatalytic activation of proMMP13 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65895", "l": "4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate <=> H2O + xanthurenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38374", "l": "1-(9Z-octadecenoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0140064", "l": "peptide crotonyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60838", "l": "a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + diphosphate => a 5'-end diphospho-adenosine in mRNA + GTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28699", "l": "Mn(2+)(in) = Mn(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "76.125169645393314", "identifiers": [{"i": "GO:0016803", "l": "ether hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018064", "l": "protein-L-histidine N-tele-methyltransferase activity"}, {"i": "MetaCyc:2.1.1.85-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66326", "l": "iodide(in) => iodide(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18320", "l": "an L-alpha-amino acid <=> a D-alpha-amino acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879222", "l": "MDP:NLRP1 binds ATP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14892", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate <=> (5Z,7E,9E,14Z,17Z)-icosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49652", "l": "H(+) + NADH + O2 + protoviolaceinate = H2O + NAD(+) + violaceinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806732", "l": "GNLY binds the bacterial cell surface (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604368", "l": "Autocatalytic activation of bound proMMP2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928654", "l": "Clathrin internalises EPH:EFN complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8871227", "l": "RET binds GFRA4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112436", "l": "Formation of Elongin complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57002", "l": "CoA + H(+) + N(beta)-acetylstreptothricin F => acetyl-CoA + streptothricin F"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45745", "l": "(6S)-5,6,7,8-tetrahydropteroate + NAD(+) => 7,8-dihydropteroate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051870", "l": "methotrexate binding"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0090600", "l": "alpha-1,3-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52558", "l": "3-dehydro-4-O-phospho-D-erythronate + ADP + H(+) => 3-dehydro-D-erythronate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30156", "l": "FADH2 + 2 Fe(3+) => FAD + 2 Fe(2+) + 3 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32904", "l": "calciol + O2 + reduced [NADPH--hemoprotein reductase] => calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008054", "l": "IL1F10 binds IL1RAPL1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21372", "l": "H(+) + H2O + urethane = CO2 + ethanol + NH4(+)"}, {"i": "EC:3.5.1.75", "l": "\"Urethanase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433395", "l": "Dimerization of sSCF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4724291", "l": "Defective ALG6 does not add glucose to the N-glycan precursor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001635", "l": "calcitonin gene-related peptide receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213241", "l": "Formation of nonameric complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806974", "l": "MET dimers autophosphorylate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53307", "l": "AH2 + 2 ATP + 2 cob(II)alamin <=> A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.205", "l": "\"Galactogen 6-beta-galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59580", "l": "hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester = CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28448", "l": "1-deoxy-D-xylulose(out) => 1-deoxy-D-xylulose(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0010420", "l": "3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008747", "l": "N-acetylneuraminate lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38504", "l": "1,3-diacyl-sn-glycerol + H2O => a 1-acyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38494", "l": "2-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36633", "l": "(2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+) => D-ribulose 1,5-bisphosphate + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044023", "l": "histone kinase activity (H4-S1 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11348", "l": "arsenite(in) + ATP + H2O = ADP + arsenite(out) + H(+) + phosphate"}, {"i": "EC:7.3.2.7", "l": "\"Arsenite-transporting ATPase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450488", "l": "BRF1 Complex recruits RNA degradation activities (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15057", "l": "(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H(+) + holo-[ACP]"}, {"i": "EC:3.1.2.14", "l": "\"Oleoyl-[acyl-carrier-protein] hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13407", "l": "CoA + H(+) + N-(4-guanidinobutyl)-4-hydroxycinnamamide => 4-coumaroyl-CoA + agmatine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56203", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-alpha-D-galactose <=> H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004051", "l": "arachidonate 5-lipoxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58249", "l": "5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O => ADP-D-ribose + H(+) + L-glutamyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37125", "l": "CoA + H(+) + N-(tetracosenoyl)-sphing-4-enine => sphing-4-enine + tetracosenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467794", "l": "Resolution of sister chromatids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10223", "l": "ATP + L-tyrosine + tRNA(Tyr) <=> AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58022", "l": "eupatolide + H2O => 6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1247960", "l": "Activation of p38 MAPK (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928591", "l": "EPH:EFN tetramers oligomerise (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848596", "l": "PTK6 binds PXN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047954", "l": "glycerol-2-phosphatase activity"}, {"i": "RHEA:13105", "l": "glycerol 2-phosphate + H2O = glycerol + phosphate"}, {"i": "EC:3.1.3.19", "l": "\"Glycerol-2-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603067", "l": "Unknown nuclease cleaves pre-piRNA in ASZ1:DDX4:MOV10L1:6xMeR-PIWIL2:pre-piRNA:TDRD1:TDRD12 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59376", "l": "4-amino-4-deoxychorismate = 4-amino-4-deoxyprephenate"}, {"i": "EC:5.4.99.67", "l": "\"4-amino-4-deoxychorismate mutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10121", "l": "adenosine in double-stranded RNA + H(+) + H2O => inosine in double-stranded RNA + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35350", "l": "3-hydroxyoctadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14586", "l": "gibberellin A12 + 5 H(+) + 3 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => CO2 + gibberellin A9 + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31341", "l": "acetyl-[ACP] + AMP + diphosphate => acetate + ATP + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46272", "l": "2 [Fe(II)-cytochrome b5] + an N-acyl-(4R)-4-hydroxysphinganine + 2 H(+) + O2 = (4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693609", "l": "ATM phosphorylates TP53 at S15 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59990", "l": "cyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH => cyclohexane-1-carbonyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879222", "l": "MDP:NLRP1 binds ATP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987214", "l": "p-STAT3 dimerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15124", "l": "dithioerythritol + thiosulfate <=> cis-1,2-dithiane-4,5-diol + 2 H(+) + hydrogen sulfide + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58904", "l": "8 (S)-methylmalonyl-CoA + 24 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH = C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)"}, {"i": "RHEA:58908", "l": "7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH = C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+)"}, {"i": "EC:2.3.1.287", "l": "\"Phthioceranic/hydroxyphthioceranic acid synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10855", "l": "dimethylallyl diphosphate + leachianone G <=> diphosphate + sophoraflavanone G"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987043", "l": "IL22RA1 binds JAK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51758", "l": "a 2-acyl-4,6-diprenylphloroglucinol + diphosphate => a 2-acyl-4-prenylphloroglucinol + dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4395231", "l": "E2F1/3:DP1/2 binds NOTCH1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46226", "l": "(E)-ferulate + CoA + H(+) => (E)-feruloyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8856808", "l": "Recruitment of AP-2 complex and clathrin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19413", "l": "ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)"}, {"i": "EC:6.1.1.20", "l": "\"Phenylalanine--tRNA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682769", "l": "LGI2 binds ADAM22,23 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46884", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24096", "l": "isoorientin + S-adenosyl-L-methionine = H(+) + isoscoparin + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.78", "l": "\"Isoorientin 3'-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050431", "l": "transforming growth factor beta binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28410", "l": "4-(gamma-L-glutamylamino)butanal + H2O + NADP(+) = 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2169046", "l": "Degradation of TGF-beta receptor complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10302", "l": "(2R)-3-phospho-glyceroyl phosphate + H(+) + NADH => D-glyceraldehyde 3-phosphate + NAD(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047633", "l": "agmatine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42104", "l": "2-hydroxyethylphosphonate + methylcob(III)alamin + S-adenosyl-L-methionine = (S)-2-hydroxypropylphosphonate + 5'-deoxyadenosine + cob(III)alamin + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46461", "l": "22R-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22R,7alpha)-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602473", "l": "Autocatalytic activation of MMP1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35670", "l": "a triacylglycerol + H2O <=> a 1,2-diacylglycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953037", "l": "E2F8 forms homodimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016428", "l": "tRNA (cytosine-5-)-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2769008", "l": "NOTCH1 PEST domain mutants bind DLL1  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63601", "l": "H2O + neocasomorphin => L-isoleucine + neocasomorphin-(1-5)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28565", "l": "D-alanine + pyridoxal 5'-phosphate <=> pyridoxamine 5'-phosphate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15862", "l": "3-ADP-2-phosphoglycerate + H2O => 3-ADP-glycerate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27971", "l": "alpha-maltotriose + H2O => alpha-D-glucose + beta-maltose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2299620", "l": "Collagen XI cross-links with collagen II (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9606151", "l": "Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782336", "l": "ADAT1 deaminates adenosine-37 in tRNA(Ala) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654515", "l": "KAL1 binds HS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11370", "l": "1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + H2O + NAD(+) => 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173739", "l": "Spontaneous hydrolysis of C3 thioester (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24072", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = 12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682020", "l": "MRN complex binds shortened telomeres (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706319", "l": "Active FLT3 binds to SLA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2545203", "l": "Deacetylation of cleaved cohesin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655835", "l": "Expression of ELOVL6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42192", "l": "(9Z)-pentadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-pentadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11364", "l": "ATP + H2O + pyruvate = AMP + 2 H(+) + phosphate + phosphoenolpyruvate"}, {"i": "EC:2.7.9.2", "l": "\"Pyruvate, water dikinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28352", "l": "UDP-beta-L-arabinopyranose => UDP-beta-L-arabinofuranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373746", "l": "SEMA4D interacts with CD45 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61992", "l": "N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156930", "l": "GTP-binding activates eEF2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5669250", "l": "PAK1 phosphorylates FLNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-167429", "l": "The receptor:G-protein complex  binds GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56594", "l": "a ketone + hydrogen cyanide => a disubstituted aliphatic (S)-hydroxynitrile"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28638", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-5-epi-aristolochene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875568", "l": "RAPGEF1 activates RAP1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63636", "l": "a medium-chain fatty acyl-AMP + holo-[ACP] = a medium-chain fatty acyl-[ACP] + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806610", "l": "Keratin filament formation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58295", "l": "25-substituted-cholesterol + beta-D-glucosyl-N-dodecanoylsphing-4E-enine <=> 25-substituted-cholesteryl beta-D-glucoside + N-dodecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1028821", "l": "Dimerization of Phospho IRF3 or phospho IRF7 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446372", "l": "Association of  PARVA with TESK1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690196", "l": "USP8 deubiquitinates RNF128 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45108", "l": "(+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase] = 13-hydroxy-alpha-tocopherol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10974", "l": "alpha-D-hexose 1-phosphate + NH4(+) => D-hexose + H(+) + phosphoramidate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46824", "l": "4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909720", "l": "IFN alpha/beta binds to IFNAR2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29263", "l": "L-leucine(in) + Na(+)(in) = L-leucine(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45496", "l": "[allophycocyanin alpha-subunit]-Cys(84)-phycocyanobilin = (2R,3E)-phycocyanobilin + apo-[allophycocyanin alpha-subunit]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018785", "l": "RHOBTB2 binds GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404144", "l": "Parenchymal atROL translocates to HSCs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31519", "l": "O2 + torulene = 3-methyl-2-butenal + 4'-apo-beta-carotenal"}, {"i": "EC:1.13.11.59", "l": "\"Torulene dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5082356", "l": "HSF1-mediated gene expression (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63090", "l": "a 2'-O-methylribonucleotide in U6 snRNA + H(+) + S-adenosyl-L-homocysteine => a ribonucleotide in U6 snRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034558", "l": "technetium (VII) reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205136", "l": "GTP-bound RAC contributes to JNK activation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33854", "l": "GDP-alpha-D-mannose + N-tetracosanoylsphinganine-(1D-myo-inositol) <=> GDP + H(+) + mannosyl-alpha-1->6-inositol phospho-N-tetracosanoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.14"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110322", "l": "Formation of Pol zeta complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030348", "l": "syntaxin-3 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46182", "l": "2-methylbutanoyl-CoA + AMP + diphosphate => 2-methylbutanoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54958", "l": "AMP + diphosphate + OPC-6-CoA => ATP + CoA + OPC-6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53123", "l": "(3beta,5alpha,17beta)-3-hydroxyandrostan-17-yl sulfate + NADP(+) <=> 5alpha-dihydrotestosterone sulfate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52253", "l": "a bacteriochlorophyllide c + H2O + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + a bacteriochlorophyllide e + 2 H(+) + 2 L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55966", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.21"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25921", "l": "A + H2O + quinolin-7-ol => 7-hydroxyquinolin-2(1H)-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14744", "l": "4-methylene-L-glutamine + H2O <=> 4-methylene-L-glutamate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36306", "l": "a fatty acyl-CoA + 2 H(+) + 2 NADPH <=> a long-chain primary fatty alcohol + CoA + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163798", "l": "Furin cleaves pro-protein Z to protein Z (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167019", "l": "SHC, complexed with TrkA, is tyrosine-phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34854", "l": "(3S)-3-hydroxyadipyl-CoA + NAD(+) <=> 3-oxoadipyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61054", "l": "(-)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72185", "l": "mRNA polyadenylation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55989", "l": "H2O + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] => beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20396", "l": "holo-[citrate lyase ACP] + S-acetylphosphopantotheine <=> acetyl-[citrate lyase ACP] + D-pantetheine 4'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32592", "l": "(4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O => (3R,6S)-6-hydroxy-3,7-dimethyloctanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508513", "l": "PTK2B binds JAK3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49581", "l": "(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate => cyclic pyranopterin phosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2471660", "l": "Defective OPN1LW causes CBP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371567", "l": "DBC1 is phosphorylated by ATM/ART (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0015666", "l": "restriction endodeoxyribonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209944", "l": "25(OH)D binds GC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48108", "l": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.320", "l": "\"Type II protein arginine methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870686", "l": "BCL2L11 (BIM) gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015514", "l": "nitrite efflux transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15248", "l": "a monoacylglycerol + H2O <=> a fatty acid + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54393", "l": "1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60318", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17464", "l": "H2O + sedoheptulose 1,7-bisphosphate <=> D-sedoheptulose 7-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23560", "l": "adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983138", "l": "Transport of MHC heterotrimer to ER exit site (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31462", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate <=> 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177923", "l": "Sustained activation of SRC kinase by SHP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48620", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64550", "l": "(3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + H(+) + holo-[ACP] => N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953398", "l": "PIR oxygenates quercetin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203977", "l": "SAR1 Activation And Membrane Binding (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47788", "l": "a cytidine in 28S rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58307", "l": "25-substituted-cholesterol + beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine <=> 25-substituted-cholesteryl beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.112", "l": "\"Anthocyanidin reductase ((2S)-flavan-3-ol-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.n6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052826", "l": "inositol hexakisphosphate 2-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61859", "l": "dehydroprobetaenone I + 3 H(+) + 3 NADPH + 3 O2 <=> betaenone C + 3 H2O + 3 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158278", "l": "factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28242", "l": "O2 + pratensein + reduced [NADPH--hemoprotein reductase] = 5-hydroxypseudobaptigenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793975", "l": "Expression of GATA3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674529", "l": "AAMP binds to TBXA2R (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51244", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19138", "l": "17beta-estradiol + AH2 + O2 => 6beta-hydroxyestradiol-17beta + A + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047367", "l": "quercetin-3,3'-bissulfate 7-sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37348", "l": "(R)-lactate + ATP + D-alanine => ADP + D-alanyl-(R)-lactate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607744", "l": "MALT1 binds BCL10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45441", "l": "H2O + N-eicosanoyl-sn-glycero-3-phosphoethanolamine => H(+) + N-eicosanoyl ethanolamine + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10266", "l": "beta-D-glucose => alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28299", "l": "(2E,6E)-farnesyl diphosphate => (E)-gamma-bisabolene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018795", "l": "2-hydroxy-2-methyl-1,3-dicarbonate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71164", "l": "homogentisate + O2 => maleylacetoacetate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940959", "l": "Neurolysin degrades neurotensin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54551", "l": "D-xylulose 1,5-bisphosphate + H2O <=> D-xylulose 5-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59524", "l": "9S,10-epoxy-(10,12Z)-octadecadienoate + H(+) + L-aspartyl-[protein] = 9-O-10-oxo-(12Z)-octadecenoate L-aspartatyl ester-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.117", "l": "\"6-aminohexanoate-oligomer endohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21449", "l": "16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] => 16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22863", "l": "ATP + H(+) + nicotinate beta-D-ribonucleotide <=> deamido-NAD(+) + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166041", "l": "Transfer of LPS onto TLR4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730851", "l": "Phosphorylation of SLP-76 by p-SYK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008685", "l": "2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"}, {"i": "KEGG.REACTION:R05637"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13733", "l": "an n-alkanal + NAD(+) = an alk-2-enal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801776", "l": "REG3A binds bacterial phospholipids (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26536", "l": "3-hydroxypropanoyl-CoA + AMP + diphosphate => 3-hydroxypropanoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047808", "l": "D(-)-tartrate dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48263", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 <=> CMP + ganglioside GD1a + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59856", "l": "[Co(I) tetramethylammonium-specific corrinoid protein] + H(+) + tetramethylammonium = [methyl-Co(III) tetramethylammonium-specific corrinoid protein] + trimethylamine"}, {"i": "EC:2.1.1.252", "l": "\"Tetramethylammonium--corrinoid protein Co-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864569", "l": "WWOX binds TFAP2C (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38270", "l": "2-methylfumaryl-CoA <=> 3-methylfumaryl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388833", "l": "Phosphorylation of CTLA-4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12083", "l": "acetyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxobutanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176973", "l": "Association of MCM8 with ORC:origin complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602473", "l": "Autocatalytic activation of MMP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41584", "l": "dimethylallyl diphosphate + L-tyrosine = 4-O-dimethylallyl-L-tyrosine + diphosphate"}, {"i": "EC:2.5.1.122", "l": "\"4-O-dimethylallyl-L-tyrosine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51332", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 = 11-hydroperoxy-(8Z,12E,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683593", "l": "ATG7:ATG3:LC3 dissociates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62567", "l": "(4S)-limonene + A + H2O <=> (4S)-perillyl alcohol + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60960", "l": "18-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose = (9Z)-18-hydroxyoctadec-9-enoate 18-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73806", "l": "AIR + CO2 => CAIR (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109639", "l": "Formation of the closed pre-initiation complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66426", "l": "ADP + H(+) + leukotriene B4(out) + phosphate => ATP + H2O + leukotriene B4(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11838", "l": "CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine => CMP-N-acetyl-beta-neuraminate + N-acetyl-beta-lactosamine"}]}
{"type": "biolink:MolecularActivity", "ic": "66.629890497735275", "identifiers": [{"i": "GO:0005261", "l": "cation channel activity"}, {"i": "REACT:R-HSA-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050045", "l": "laminaribiose phosphorylase activity"}, {"i": "RHEA:16617", "l": "beta-D-glucosyl-(1->3)-D-glucose + phosphate = alpha-D-glucose 1-phosphate + D-glucose"}, {"i": "EC:2.4.1.31", "l": "\"Laminaribiose phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0017080", "l": "sodium channel regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48735", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O <=> [CysO sulfur-carrier protein]-C-terminal Gly-Gly + H(+) + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008445", "l": "D-aspartate oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15951", "l": "2-oxodecanoate + H(+) + NADH => (R)-2-hydroxyoctadecanoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199579", "l": "KIR2DL4 interacting with HLA-G (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27628", "l": "beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57666", "l": "alpha-nootkatol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-valencene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.5", "l": "\"Apyrase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4411373", "l": "NLK translocates to nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433415", "l": "Activation of RAC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003872", "l": "6-phosphofructokinase activity"}, {"i": "REACT:R-HSA-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8934446", "l": "Activated PKC phosphorylates SHC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033479", "l": "Dimerization of FGFR2 point mutants with enhanced kinase activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419011", "l": "Transhomodimerization of Nectins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33656", "l": "(9Z)-octadecenoate(out) => (9Z)-octadecenoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53676", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55790", "l": "H2O + hydroxyacetone + NAD(+) => acetone + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48021", "l": "globoside Gb3Cer + H2O => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5250217", "l": "ARL2:GTP binds ARL2BP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39578", "l": "3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031073", "l": "cholesterol 26-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985153", "l": "OASL binds DDX58 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25697", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + isopentenyl diphosphate <=> (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46871", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli) <=> a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30825", "l": "H2O + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose => UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983259", "l": "Kinesins move along microtubules consuming ATP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173754", "l": "Properdin stabilizes C3b:Bb bound to cell surfaces (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050157", "l": "ornithine racemase activity"}, {"i": "RHEA:11584", "l": "L-ornithine = D-ornithine"}, {"i": "EC:5.1.1.12", "l": "\"Ornithine racemase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49348", "l": "2,2-dihydroxyspirilloxanthin = 2-oxospirilloxanthin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683764", "l": "Spike trimer translocates to ERGIC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247849", "l": "WLS dissociates from retromer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49002", "l": "4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NAD(+) => aurachin C + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-741386", "l": "RIP2 induces K63-linked ubiquitination of NEMO (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43957", "l": "15-methylhexadecanoate + H(+) + NADPH + O2 => H2O + NADP(+) + omega-hydroxy-15-methyl-hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43660", "l": "ATP + hydrogencarbonate + propanoyl-CoA = ADP + H(+) + methylmalonyl-CoA + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140560", "l": "xylosyl alpha-1,3-xylosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210881", "l": "Dimerization of Tie2/Ang1 complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52735", "l": "3'-phosphoadenylyl sulfate + an 11-hydroxyjasmonate <=> adenosine 3',5'-bisphosphate + an 11-sulfojasmonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44748", "l": "5-amino-1-(beta-D-ribosyl)imidazole + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+)"}, {"i": "EC:2.7.1.223", "l": "\"Aminoimidazole riboside kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43927", "l": "NAD(+) + pregnenolone <=> H(+) + NADH + pregn-5-ene-3,20-dione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264458", "l": "Proteasome mediated degradation of COP1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.27"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052706", "l": "histidine N-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418662", "l": "Src activation following P2Y purinoceptor activation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015069", "l": "scyllo-inosamine-4-phosphate amidinotransferase activity"}, {"i": "MetaCyc:2.1.4.2-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047071", "l": "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47633", "l": "H2O + L-arginine + NAD(+) => 5-guanidino-2-oxopentanoate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033943", "l": "galactan 1,3-beta-galactosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46872", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA = a 2-acyl-sn-glycero-3-phosphocholine + lipid IIB"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18436", "l": "cyclohexylamine + H2O + O2 <=> cyclohexanone + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198563", "l": "IDO1 dioxygenates L-Trp to NFK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507873", "l": "Aquaporins passively transport urea out of cells (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44114", "l": "CoA + nonyl hexadecanoate => hexadecanoyl-CoA + nonan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16992", "l": "1D-myo-inositol hexakisphosphate + H2O <=> 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9655046", "l": "Cleavage of FXII variant by KLKB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62047", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphoglycerol + H2O <=> (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphoglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797245", "l": "Expression of FASLG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63157", "l": "H2O + N-docosanoyl-taurine => docosanoate + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791092", "l": "Expression of DCTN1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27751", "l": "2'-deoxyinosine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58354", "l": "CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate => 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32456", "l": "(-)-vetispiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + solavetivone"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080118", "l": "brassinosteroid sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.15", "l": "\"(Methyl)glyoxal oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44667", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a fatty acid + a monoacyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55207", "l": "5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.20", "l": "\"Phosphatidylglycerol--membrane-oligosaccharide glycerophosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211948", "l": "CYP3A4 can N-demethylate loperamide (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3204303", "l": "MRE11 binds cytosolic DNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44648", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 2-acyl-sn-glycerol 3-phosphate + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29640", "l": "alpha-maltohexaose + H2O => alpha-D-glucose + alpha-maltopentaose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56497", "l": "gypsogenin + O2 + reduced [NADPH--hemoprotein reductase] => gypsogenate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61833", "l": "(24R)-ethylcholest-5-en-3beta-ol + UDP-alpha-D-glucose => H(+) + sitosteryl 3-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621571", "l": "CD209 binds ICAM2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694428", "l": "LMAN family proteins bind glycosylated cargo (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.174", "l": "\"Rhamnogalacturonan rhamnohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16018", "l": "2-oxoglutarate + L-ornithine => 5-amino-2-oxopentanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21110", "l": "2-methylbutanal + CO2 => (S)-3-methyl-2-oxopentanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110363", "l": "FEN1 bound to PCNA and APEX1 cleaves flap ssDNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10366", "l": "(3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+) => 2-oxoglutarate + dodecanoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43973", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => H(+) + hexadecanoate + hexadecanoyl-glycero-3-phospho-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77589", "l": "Recognition of AAUAAA sequence by CPSF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15055", "l": "(6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide => (6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373875", "l": "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944265", "l": "Association of procollagen type IV (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58226", "l": "5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide => L-glutamyl-[protein] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72672", "l": "The 60S subunit joins the translation initiation complex  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34151", "l": "3-amino-2,3-dideoxy-scyllo-inosose + L-glutamine = 2-deoxystreptamine + 2-oxoglutaramate"}, {"i": "EC:2.6.1.101", "l": "\"L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2562526", "l": "PLK1 phosphorylates OPTN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0016753", "l": "O-sinapoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13494", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) => (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36875", "l": "(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614271", "l": "Autocleavage of ADGRG6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14264", "l": "(E)-sinapoyl-CoA + D-glucono-1,5-lactone <=> 6-O-[(E)-sinapoyl]-D-glucono-1,5-lactone + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59512", "l": "acetylsalicylate + L-seryl-[protein] = O-acetyl-L-seryl-[protein] + salicylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35539", "l": "cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2 = albonoursin + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31777", "l": "11-cis-retinol + H(+) + hexadecanoate => all-trans-retinyl hexadecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38920", "l": "H2O + sphing-4-enine-phosphocholine => choline + H(+) + sphing-4-enine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61523", "l": "AH2 + dopamine <=> 3-tyramine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45960", "l": "24,25-dihydrolanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936659", "l": "PAPS is dephosphorylated to APS (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14303", "l": "4-pyridoxate + H(+) => 4-pyridoxolactone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65602", "l": "2 H(+) + jolkinol C + 2 NADH => 4,5,8-trihydroxycasbene + 2 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45120", "l": "(4R)-ipsdienol + NAD(+) = H(+) + ipsdienone + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41187", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938174", "l": "PF4 gene transcription is stimulated by RUNX1:CBFB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "77.690207805941611", "identifiers": [{"i": "GO:0140297", "l": "DNA-binding transcription factor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983144", "l": "Transport of Antigen peptide in to ER (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40898", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676599", "l": "sBAFF trimer binds BAFFR (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13000", "l": "(E)-feruloyl-CoA + galactarate <=> 2-O-[(E)-feruloyl]-D-galactarate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37729", "l": "1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21095", "l": "12-hydroxydihydrochelirubine + S-adenosyl-L-methionine <=> dihydromacarpine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400272", "l": "FBXL3 binds phosphorylated CRY proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18870", "l": "ATP + L-xylulose => ADP + H(+) + L-xylulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35832", "l": "2-oxoglutarate + kanamycin B + O2 => 2'-dehydrokanamycin A + CO2 + NH4(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849463", "l": "PTK6 phosphorylates SFPQ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53227", "l": "16alpha,17alpha-dihydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta,16alpha-dihydroxy-androst-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801675", "l": "PLK2 phosphorylates NPM1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664879", "l": "ATM:PEX5 binds ATM (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18090", "l": "H2O + L-arginyl-[protein] => L-citrullyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40312", "l": "hexanoyl-CoA + O2 => (2E)-hexenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10117", "l": "6-phospho-D-gluconate + NADP(+) => CO2 + D-ribulose 5-phosphate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67169", "l": "2-oxoglutarate + 3-hydroxy-L-phenylalanine => 3-(3-hydroxyphenyl)pyruvate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379844", "l": "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58228", "l": "L-asparaginyl-[protein] + NAD(+) = H(+) + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23591", "l": "oxalate + succinyl-CoA <=> oxalyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51790", "l": "2-hydroxybenzoyl-CoA + AMP + H(+) => 2-hydroxybenzoyl-5'-AMP + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045485", "l": "omega-6 fatty acid desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21555", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63784", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381091", "l": "IRE1 dimer autophosphorylates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-448963", "l": "Interaction of MyoD:E protein with MEF2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47927", "l": "2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate <=> (S)-3-sulfolactaldehyde + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10275", "l": "a 1,2-diacyl-sn-glycerol + ATP <=> a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44079", "l": "ATP + CoA + pentadecanoate <=> AMP + diphosphate + pentadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047472", "l": "3-carboxy-cis,cis-muconate cycloisomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32672", "l": "ATP + UDP-N-acetyl-alpha-D-glucosamine => ADP + H(+) + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-217255", "l": "FMO1:FAD N-oxidises TAM (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-434989", "l": "SEMA7A binds to PLXNC1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046353", "l": "aminoglycoside 3-N-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210290", "l": "Interaction of PECAM-1 and SHIP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57062", "l": "acetate + ADP-D-ribose + H(+) => 2''-O-acetyl-ADP-D-ribose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30929", "l": "5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose => 2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2176452", "l": "Degradation of ubiquitinated SMAD2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68637", "l": "CDC6 protein is synthesized under the control of E2F transcription factors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60261", "l": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004087", "l": "carbamoyl-phosphate synthase (ammonia) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166220", "l": "FA anion diffuses laterally to UCP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0016502", "l": "nucleotide receptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050619", "l": "phytochromobilin:ferredoxin oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809680", "l": "MTMR12 binds MTM1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19871", "l": "an N-acylglycine + CoA + H(+) => an acyl-CoA + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49966", "l": "H2O2 + phenazine => 5,10-dihydrophenazine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641134", "l": "SMURF2 binds AXIN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018573", "l": "NOTCH3 binds activated EGFR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69053", "l": "RFC binding displaces Pol Alpha (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849857", "l": "KLK5 cleaves and activates CELA2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19098", "l": "AH2 + 2 ATP + benzoyl-CoA + 2 H2O => A + 2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32346", "l": "(+)-thujan-3-ol + NAD(+) <=> (+)-thujan-3-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22608", "l": "H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + succinate"}, {"i": "EC:3.5.1.18", "l": "\"Succinyl-diaminopimelate desuccinylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033907", "l": "beta-D-fucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610726", "l": "The IFT-A complex recruits TULP3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047916", "l": "GDP-6-deoxy-D-talose 4-dehydrogenase activity"}, {"i": "MetaCyc:GDP-6-DEOXY-D-TALOSE-4-DEHYDROGENASE-RXN"}, {"i": "EC:1.1.1.135", "l": "\"GDP-6-deoxy-D-talose 4-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373875", "l": "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204364", "l": "ROBO1 binds SLIT2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46817", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13154", "l": "(R)-glycerate + CO2 + NAD(+) => 2-hydroxy-3-oxosuccinate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38323", "l": "2 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14835", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH => (R)-mevalonate + CoA + 2 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102911", "l": "(-)-secoisolariciresinol dehydrogenase activity"}, {"i": "MetaCyc:RXN-8680"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951644", "l": "Release of mature NEDD8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950448", "l": "STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24257", "l": "ATP + kanamycin A => ADP + H(+) + kanamycin 3'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42477", "l": "2,2',3-trihydroxydiphenyl ether + H(+) + O2 => 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618586", "l": "E2F1 binds the promoter of the MYC gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14482", "l": "2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O => 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5685230", "l": "CHEK1 phosphorylates RAD51 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23149", "l": "ATP + propanoate => ADP + propanoyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49406", "l": "alpha-D-mannose 1-phosphate + D-mannose => beta-D-mannopyranosyl-(1->2)-D-mannopyranose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5620975", "l": "MLKL binds PIPs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50311", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110322", "l": "Formation of Pol zeta complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000109", "l": "CD320:TCII:Cbl dissociates into CD320 and TCII:Cbl (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696146", "l": "AOC2 deaminates TYR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046404", "l": "polydeoxyribonucleotide 5'-hydroxyl-kinase activity"}, {"i": "MetaCyc:POLYNUCLEOTIDE-5-HYDROXYL-KINASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247960", "l": "Activation of p38 MAPK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247843", "l": "secretion of WNT ligands (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18105", "l": "ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate"}, {"i": "EC:7.2.2.10", "l": "\"P-type Ca(2+) transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11079", "l": "anthranilate + 3 H(+) + NADH + O2 <=> catechol + CO2 + NAD(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043262", "l": "adenosine-diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373867", "l": "BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61058", "l": "H(+) + H2O + lochnericine + oxidized [NADPH--hemoprotein reductase] => (-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18961", "l": "D-allose + L-lysyl-[protein] = H2O + N(6)-(D-psicosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40074", "l": "2-aminoprop-2-enoate + H2O <=> NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66983", "l": "2-methylbutanoyl-CoA + H2O <=> 2-methylbutanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34907", "l": "molybdate(in) = molybdate(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0000828", "l": "inositol hexakisphosphate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65677", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontadienoyl)-sphing-4-enine => a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontadienoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34691", "l": "(R)-lactoyl-CoA = acryloyl-CoA + H2O"}, {"i": "EC:4.2.1.54", "l": "\"Lactoyl-CoA dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50858", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17948", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11772", "l": "6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH"}, {"i": "EC:1.1.1.220", "l": "\"6-pyruvoyltetrahydropterin 2'-reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24551", "l": "an N(6)-acyl-L-lysine + H2O <=> a carboxylate + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65657", "l": "A + cholest-1,4-dien-3-one + H2O => 25-hydroxycholest-1,4-dien-3-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43825", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0052664", "l": "nitroalkane oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27398", "l": "4'-demethylrebeccamycin + H2O => beta-D-glucose + dichloroarcyriaflavin A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11291", "l": "dihydromacarpine + H(+) + O2 <=> H2O2 + macarpine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432143", "l": "PECAM-1 binds PP2A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694793", "l": "Spike protein gets N-glycosylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9037040", "l": "SRC,FYN phosphorylate NTRK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19724", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA <=> (9Z)-octadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46457", "l": "5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH => 5alpha-cholest-8-en-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40973", "l": "2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57689", "l": "apo-[corrinoid adenosyltransferase] + cob(II)inamide => cob(II)inamide--[corrinoid adenosyltransferase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61730", "l": "a 3-dehydro-D-glucoside => a 3-dehydro-D-guloside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37003", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(13Z,16Z,19Z)-docosatrienoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10672", "l": "cyclobutadithymidine in DNA = a thymidine dimer in DNA"}, {"i": "EC:4.1.99.3", "l": "\"Deoxyribodipyrimidine photo-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-164840", "l": "ADP and Pi bind to ATPase (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.2.4", "l": "\"Fatty-acid peroxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49341", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin => 2-hydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35198", "l": "L-quinate(in) <=> L-quinate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444606", "l": "T1R2/T1R3 dimer is a sweet taste receptor (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605595", "l": "Hexosaminidase A cleaves GalNAc from GM2 to form GM3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004914", "l": "interleukin-5 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24194", "l": "(2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+) => (2R,4S)-2,4-diaminopentanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70982", "l": "Fumarate + H2O <=> (S)-Malate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59337", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene + A => AH2 + demethylspheroidene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875451", "l": "MET phosphorylates CBL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14277", "l": "(S)-lactaldehyde + H2O + NAD(+) = (S)-lactate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.22", "l": "\"Lactaldehyde dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006508", "l": "PVALB gene expression is repressed by MECP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198756", "l": "ERK1/2 phosphorylates MSK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202969", "l": "Caspase mediated cleavage of beta-catenin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55351", "l": "all-trans-retinol <=> 9-cis-retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38174", "l": "hexadecane-1,2-diol + hexadecanoyl-CoA <=> 2-hydroxyhexadecyl hexadecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33921", "l": "24,25-dihydrolanosterol + NADP(+) => H(+) + lanosterol + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41211", "l": "(indol-3-yl)acetate + H(+) + NADH + O2 = 2-hydroxy-(1H-indol-3-yl)acetate + H2O + NAD(+)"}, {"i": "EC:1.14.13.235", "l": "\"Indole-3-acetate monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27360", "l": "iodide + S-adenosyl-L-methionine <=> iodomethane + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668467", "l": "2xTNFR2 binds TNFA trimer:TNFR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19163", "l": "2 6-iminocyclohexa-2,4-dienone + 2 H2O => 2 2-aminophenol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59783", "l": "L-histidine + S-adenosyl-L-methionine <=> (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202325", "l": "Recruitment of Gads to LAT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47131", "l": "ATP + CoA + deoxycholate <=> AMP + deoxycholoyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014456", "l": "GDIs block activation of RHOG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195730", "l": "Transport of processed viral proteins to the cell membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031924", "l": "vitamin B6 transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0005368", "l": "taurine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35455", "l": "5alpha-cholest-7-en-3-one + 2 H(+) + 3 NADPH + 3 O2 = (25S)-Delta7-dafachronate + 4 H2O + 3 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27400", "l": "4'-demethylrebeccamycin + H2O <=> beta-D-glucose + dichloroarcyriaflavin A"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062063", "l": "BBSome binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-443783", "l": "Interaction of NUMB with L1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2172126", "l": "DAP12 interacts with NKG2C (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913725", "l": "viral dsRNA binds IFIH1:TKFC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9690494", "l": "RHOB translocates to the endosome membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371385", "l": "TNF-alpha is cleaved by ADAM17 (TACE) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912627", "l": "CBL ubiquitinates PI3K (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32155", "l": "7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine"}, {"i": "EC:2.4.99.17", "l": "\"S-adenosylmethionine:tRNA ribosyltransferase-isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391935", "l": "DP1 receptor can bind PGD2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196753", "l": "2xPPCS ligates PPanK with Cys (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66804", "l": "ferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + pisiferate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937177", "l": "AHR:TCDD binds ARNT (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52570", "l": "epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP => epitestosterone + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2219524", "l": "PDPK1 binds PIP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44502", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+) => 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40017", "l": "13-epi-manool + diphosphate => (+)-copalyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36674", "l": "(17Z)-hexacosenoyl-CoA + sphinganine <=> CoA + H(+) + N-[(17Z)-hexacosenoyl]dihydrosphingosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58534", "l": "akuammicine + formate + H(+) => 15alpha-stemmadenine intermediate I + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047352", "l": "adenylylsulfate-ammonia adenylyltransferase activity"}, {"i": "KEGG.REACTION:R01619"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28992", "l": "N-acetylneuraminate(in) => N-acetylneuraminate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64215", "l": "an N-(fatty acyl)-L-isoleucine + H2O <=> a fatty acid + L-isoleucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.99.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39941", "l": "(9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+) => 1,3-di-(9Z-octadecenoyl)-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902936", "l": "phosphatidylinositol bisphosphate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42328", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28820", "l": "5-dehydro-D-gluconate(in) + H(+)(in) => 5-dehydro-D-gluconate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66455", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + NADP(+) <=> 1-(9Z)-octadecenoylglycerone 3-phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46471", "l": "an N-(acyl)-sphingosylphosphocholine(in) + ATP + H2O <=> ADP + an N-(acyl)-sphingosylphosphocholine(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31321", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H(+) + UDP => (2R)-3-phosphoglycerate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56760", "l": "24,25-dihydrolanosterol + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21883", "l": "2 H(+) + O2 + oxalate <=> 2 CO2 + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19369", "l": "L-histidyl-[protein] + S-adenosyl-L-methionine = H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.85", "l": "\"Protein-histidine N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24783", "l": "C-13(2)-carboxypyropheophorbide a + H(+) <=> CO2 + pyropheophorbide a"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044689", "l": "7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity"}, {"i": "RHEA:55200", "l": "5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine"}, {"i": "EC:2.5.1.147", "l": "\"5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51366", "l": "CoA + H(+) + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27849", "l": "(2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2 <=> (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61935", "l": "(S)-miconazole(in) + ATP + H2O <=> (S)-miconazole(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61922", "l": "(2R,4S)-ketoconazole(out) + ADP + H(+) + phosphate => (2R,4S)-ketoconazole(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357429", "l": "AXL autophosphorylates on Y772 and Y814 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675790", "l": "MTORC1 dissociates from ULK complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64549", "l": "N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] => (3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031531", "l": "thyrotropin-releasing hormone receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36238", "l": "1-O-alkyl-sn-glycero-3-phosphate + an acyl-CoA <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003721", "l": "telomerase RNA reverse transcriptase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26080", "l": "methanesulfonate + NADH + O2 <=> formaldehyde + H2O + NAD(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "ic": "65.690062451777465", "identifiers": [{"i": "GO:0016645", "l": "oxidoreductase activity, acting on the CH-NH group of donors"}, {"i": "EC:1.5.-.-", "l": "\"Acting on the CH-NH group of donors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29012", "l": "2-oxoglutarate(in) + H(+)(in) => 2-oxoglutarate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11134", "l": "H(+) + NADPH + protochlorophyllide a => chlorophyllide a + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28563", "l": "D-alanine + pyridoxal 5'-phosphate => pyridoxamine 5'-phosphate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37617", "l": "1'-[1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419841", "l": "Light stimulates opsin receptors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45463", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a fatty acid + H(+) + N,1-diacyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008691", "l": "3-hydroxybutyryl-CoA dehydrogenase activity"}, {"i": "RHEA:16197", "l": "(3S)-3-hydroxybutanoyl-CoA + NADP(+) = acetoacetyl-CoA + H(+) + NADPH"}, {"i": "EC:1.1.1.157", "l": "\"3-hydroxybutyryl-CoA dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76426", "l": "N-atom dealkylation of caffeine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.115", "l": "\"Infectious pancreatic necrosis birnavirus Vp4 peptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45908", "l": "chloroorienticin B + dTDP-beta-L-vancosamine = chloroeremomycin + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917730", "l": "Cargo Recognition And Sorting (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59726", "l": "D-maltoheptaonate + H(+) => D-maltoheptaono-1,5-lactone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371590", "l": "HSP70 binds to HSP40:nascent protein (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18650", "l": "D-galactonate => 2-dehydro-3-deoxy-D-galactonate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.37", "l": "\"Xylan 1,4-beta-xylosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59363", "l": "carnosine + H2O <=> beta-alanine + L-histidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39831", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoate + O2 = 2-hydroxyhexadecanoate + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018559", "l": "1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008526", "l": "phosphatidylinositol transfer activity"}, {"i": "REACT:R-HSA-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Homo sapiens)"}, {"i": "REACT:R-HSA-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58812", "l": "ATP + H2O + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate = AMP + diphosphate + H(+) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate"}, {"i": "EC:5.1.1.23", "l": "\"UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30144", "l": "H2O + octanoyl-CoA => CoA + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004859", "l": "phospholipase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657651", "l": "MGMT binds alkylated DNA containing 6-O-methylguanine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374298", "l": "Opioid receptors bind opioid peptides (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43782", "l": "(2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein] => 2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37668", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052903", "l": "N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196026", "l": "Dab2 is recruited to the junctional plaques (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36173", "l": "1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+) => a 1-acylglycerone 3-phosphate + a long chain fatty alcohol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168184", "l": "Activated TAK1 mediates phosphorylation of the IKK Complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265177", "l": "Exocyst complex formation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21151", "l": "indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose <=> 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31666", "l": "2-oxoglutarate + UDP-N-acetylbacillosamine <=> L-glutamate + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549322", "l": "OCT1 transports organic cations out of hepatic cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51376", "l": "dopamine + hexadecanoyl-CoA = CoA + H(+) + N-hexadecanoyl-dopamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205112", "l": "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050480", "l": "imidazolonepropionase activity"}, {"i": "RHEA:23660", "l": "4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate"}, {"i": "EC:3.5.2.7", "l": "\"Imidazolonepropionase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54211", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 <=> 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64462", "l": "H(+) + N(6)-acetyl-L-lysyl-[protein] + phosphate => acetyl phosphate + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15845", "l": "4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP-alpha-D-glucose = 4-O-{[(2R)-2-alpha-D-glucosyl-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n H(+) + n UDP"}, {"i": "EC:2.4.1.52", "l": "\"Poly(glycerol-phosphate) alpha-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26266", "l": "dehydroabietadienal + H2O + NADP(+) => dehydroabietate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42059", "l": "13-cis-retinol + NAD(+) <=> 13-cis-retinal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687465", "l": "MRN complex binds RBBP8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985227", "l": "The complex of RUNX2 and WWTR1 (TAZ) binds the BGLAP gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433488", "l": "Phosphorylation of SHP2 by SFKs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32555", "l": "(2E)-geranyl diphosphate + H2O = (R)-alpha-terpineol + diphosphate"}, {"i": "EC:4.2.3.112", "l": "\"(+)-alpha-terpineol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48792", "l": "GDP-beta-L-fucose + Lc4Cer = alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31131", "l": "5,10-methenyltetrahydrofolate + H2O + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + 2 H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190829", "l": "Lysosomal degradation of gap junction plaques (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48952", "l": "14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22284", "l": "2 H(+) + H2O + N-carbamoylputrescine = CO2 + NH4(+) + putrescine"}, {"i": "EC:3.5.1.53", "l": "\"N-carbamoylputrescine amidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50975", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 <=> (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-383190", "l": "HCO3- transport through ion channel (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322427", "l": "Beta-catenin recruits CBP/p300 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37158", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19787", "l": "clavaminate + CO2 + H2O + succinate => 2-oxoglutarate + dihydroclavaminate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444171", "l": "Receptor FFAR2 binds carboxylates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20561", "l": "3-hydroxypyruvate + H(+) = CO2 + glycolaldehyde"}, {"i": "EC:4.1.1.40", "l": "\"Hydroxypyruvate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617829", "l": "Assembly of IFT A complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170796", "l": "NPC transports GCK1:GKRP from cytosol to nucleoplasm (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199456", "l": "PTEN dephosphorylates PIP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102537", "l": "ecdysone-phosphate phosphatase activity"}, {"i": "MetaCyc:RXN-14766"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39135", "l": "(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + O2 = (2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080130", "l": "L-phenylalanine:2-oxoglutarate aminotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662710", "l": "IL6 gene produces IL6 protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74059", "l": "PDE6 hydrolyses cGMP to GMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938913", "l": "RUNX1 binds ELF1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33321", "l": "a 1-acyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029531", "l": "Expression of ABCG5 regulated by NR1H2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19768", "l": "glycerol <=> 3-hydroxypropanal + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30169", "l": "sedoheptulose 1,7-bisphosphate => D-erythrose 4-phosphate + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57561", "l": "(+)-cis-trans-nepetalactol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 7-deoxyloganetate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606392", "l": "Lewis antigens translocate from Golgi lumen to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362549", "l": "Hh-Np traffics to the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198513", "l": "Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37873", "l": "2-heptyl-3-hydroxy-4(1H)-quinolone + H2O + NAD(+) => 2-heptyl-4(1H)-quinolone + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416690", "l": "SEMA4A binds to PLXND1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645692", "l": "C1QBP promotes translocation of p14ARF to the mitochondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014433", "l": "RHOG GEFs activate RHOG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54966", "l": "hexadecanoyl phosphate + holo-[ACP] => hexadecanoyl-[ACP] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209925", "l": "DIT and MIT combine to form triiodothyronine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "77.02358060617253", "identifiers": [{"i": "GO:0022884", "l": "macromolecule transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13076", "l": "guanosine 3'-diphosphate 5'-triphosphate + H2O <=> guanosine 3',5'-bis(diphosphate) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39342", "l": "(9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64710", "l": "butanal + H(+) + NADPH => butan-1-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24974", "l": "(1S)-1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin] => calcitetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61832", "l": "(24R)-ethylcholest-5-en-3beta-ol + UDP-alpha-D-glucose = H(+) + sitosteryl 3-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009675", "l": "high-affinity sulfate:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40365", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173725", "l": "C9 binds C5b:C6:C7:C8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937989", "l": "RUNX1 binds PRC1 complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66344", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + ATP + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46535", "l": "2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23862", "l": "cephalosporin C + CoA => acetyl-CoA + deacetylcephalosporin C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5607746", "l": "PKC-delta is activated (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296326", "l": "HCAR1 binds LACT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23843", "l": "3-(2,3-dihydroxyphenyl)propanoate + O2 <=> (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265177", "l": "Exocyst complex formation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193705", "l": "IKKbeta phosphorylates IkB causing NF-kB to dissociate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58529", "l": "15alpha-stemmadenine intermediate I + H2O + NADPH => (16R)-deshydroxymethyl-stemmadenine + formate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35156", "l": "(S)-4,5-dihydroxypentane-2,3-dione => (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2484822", "l": "Kinetochore assembly (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26113", "l": "H2O + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003957", "l": "NAD(P)+ transhydrogenase (B-specific) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0030228", "l": "lipoprotein particle receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197770", "l": "STAB1 (FEEL-1) binds ligands (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0010340", "l": "carboxyl-O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20766", "l": "oxaloacetate + propanoyl-CoA => (S)-methylmalonyl-CoA + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23237", "l": "[protein]-L-glutamate 5-O-methyl ester + H2O => H(+) + L-glutamyl-[protein] + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17034", "l": "(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) => biphenyl-2,3-diol + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018766", "l": "RHOU binds effectors at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008587", "l": "IL37, IL37(?-218) binds IL18BP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51694", "l": "3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O => prephenate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004984", "l": "olfactory receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26556", "l": "angiotensin-(1-7) + L-phenylalanine => angiotensin II + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40993", "l": "3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA => (E)-4-coumaroyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14761", "l": "H(+) + hexadecanoyl-CoA + L-serine = 3-oxosphinganine + CO2 + CoA"}, {"i": "EC:2.3.1.50", "l": "\"Serine C-palmitoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13177", "l": "6-phospho-5-dehydro-2-deoxy-D-gluconate = 3-oxopropanoate + dihydroxyacetone phosphate"}, {"i": "EC:4.1.2.29", "l": "\"5-dehydro-2-deoxyphosphogluconate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28754", "l": "sn-glycerol 3-phosphate + ubiquinone-8 <=> dihydroxyacetone phosphate + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40751", "l": "(9Z)-octadecenoate + 1-hexadecanoylglycerone 3-phosphate = 1-(9Z)-octadecenoylglycerone 3-phosphate + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25043", "l": "L-selenocysteinyl-tRNA(Sec) + 2 phosphate => H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483174", "l": "PE is methylated to PC by PEMT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24639", "l": "H2 + NAD(+) <=> H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19000", "l": "CTP + H(+) + phosphocholine <=> CDP-choline + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41895", "l": "(3R)-hydroxytetradecanoyl-[ACP] <=> (2E)-tetradecenoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018767", "l": "2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9650473", "l": "SERPING1 is secreted (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20135", "l": "H(+) + indole-3-pyruvate + NADH => 3-(indol-3-yl)lactate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13369", "l": "dimethylallyl diphosphate = diphosphate + isoprene"}, {"i": "EC:4.2.3.27", "l": "\"Isoprene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45123", "l": "(4R)-ipsdienol + NAD(+) <=> H(+) + ipsdienone + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050681", "l": "androgen receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.1", "l": "\"Atrolysin A\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61537", "l": "ent-kaur-16-ene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44755", "l": "2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36636", "l": "4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine => 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449077", "l": "Interleukin-16 is secreted (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141139", "l": "Trimerization of TRAIL:TRAIL receptor complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10365", "l": "2-oxoglutarate + dodecanoyl-CoA + H2O => (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47471", "l": "(2E,4E)-tetradecadienoyl-CoA <=> (3E,5Z)-tetradecadienoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60819", "l": "2-oxoglutarate + gibberellin A14 aldehyde + O2 <=> CO2 + gibberellin A14 + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061628", "l": "H3K27me3 modified histone binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45647", "l": "H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine <=> H(+) + N-hexadecanoylsphing-4-enine + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951644", "l": "Release of mature NEDD8 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340214", "l": "CYGB binds O2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37836", "l": "aklavinone + H(+) + NADPH + O2 => epsilon-rhodomycinone + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56199", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-alpha-D-galactose <=> H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202692", "l": "PIP3 binds to RhoA and activates it (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35443", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-xylose = an anthocyanidin 3-O-beta-D-sambubioside + 2 H(+) + UDP"}, {"i": "EC:2.4.2.51", "l": "\"Anthocyanidin 3-O-glucoside 2'''-O-xylosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49269", "l": "25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 23S,25-dihydroxy-24-oxocholecalciferol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9640195", "l": "RRAGA,B hydrolyzes GTP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18668", "l": "(2R)-3-phospho-glyceroyl phosphate + [phosphate](n) <=> (2R)-3-phosphoglycerate + [phosphate](n+1)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109700", "l": "AKT2 binds PIP3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791035", "l": "Release of NS1 homodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047694", "l": "barbiturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48589", "l": "2 H2O + 2 leukotriene A4 + O2 => 2 lipoxin B4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31488", "l": "soyasapogenol B 3-O-beta-D-glucuronate + UDP-alpha-D-galactose => H(+) + soyasaponin III + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24953", "l": "1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O => ADP + H(+) + N-acetyl-D-muramate 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9671145", "l": "DKC1 binds SHQ1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15048", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) <=> (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28850", "l": "Li(+)(in) + melibiose(in) <=> Li(+)(out) + melibiose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35842", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA <=> a cardiolipin + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12282", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62485", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O => 2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61158", "l": "CoA + GDP + H(+) => 3'-dephospho-CoA + GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852337", "l": "GTSE1 binds TP53 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39215", "l": "(2E)-hexacosenoyl-CoA + H(+) + NADPH = hexacosanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853429", "l": "PHLDA1 binds AURKA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29334", "l": "fumarate(in) + 2 H(+)(in) <=> fumarate(out) + 2 H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442913", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20714", "l": "(S)-8-amino-7-oxononanoate + CO2 + CoA => 6-carboxyhexanoyl-CoA + H(+) + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59145", "l": "10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide => 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48046", "l": "D-galactose + ganglioside GM2 (d18:1(4E)/18:0) => ganglioside GM1 (d18:1(4E)/18:0) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11827", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41823", "l": "butanoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103107", "l": "castasterone 23-O-glucosyltransferase activity"}, {"i": "MetaCyc:RXNQT-4398"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102331", "l": "heptadecanoyl-[acp] elongase/decarboxylase activity"}, {"i": "MetaCyc:RXN-13259"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31005", "l": "germanicol => (S)-2,3-epoxysqualene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63219", "l": "7-cyano-7-carbaguanosine(15) in tRNA + L-lysine <=> 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696605", "l": "USP12, USP26 deubiquitinate AR (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72722", "l": "eIF2 activation (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22971", "l": "butanal + CoA + NAD(+) <=> butanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417890", "l": "P2Y5 receptor can bind to LPA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75244", "l": "FASL binds FAS Receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624668", "l": "CEBPA binds CDKN1A (p21) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.12.-", "l": "\"Exodeoxyribonucleases producing 3'-phosphomonoesters\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28852", "l": "melibiose(in) + Na(+)(in) => melibiose(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676595", "l": "TRAFs bind RANK:RANKL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102254", "l": "neoagarotetraose 1,3-alpha-3,6-anhydro-L-galactosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14811", "l": "anisole + H(+) + S-adenosyl-L-homocysteine => phenol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20450", "l": "5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2 => 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23008", "l": "alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate"}, {"i": "EC:3.2.1.93", "l": "\"Alpha,alpha-phosphotrehalase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10165", "l": "(2R)-2-phosphoglycerate => H2O + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47516", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH = isochenodeoxycholate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70486", "l": "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167147", "l": "Separation of abortive HIV-1 transcript from template (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004478", "l": "methionine adenosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68603", "l": "ORC5 binds ORC2:ORC3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698026", "l": "FLT3 ITD- and STAT5-dependent BCL2L1 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25139", "l": "(2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) = 3-amino-2-oxopropyl phosphate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37886", "l": "acetyl-CoA + oxalate <=> acetate + oxalyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10707", "l": "ATP + L-valine + tRNA(Val) <=> AMP + diphosphate + L-valyl-tRNA(Val)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983153", "l": "E1 mediated ubiquitin activation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39960", "l": "1-hexadecanoylglycerol + H2O => glycerol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451418", "l": "Pellino ubiquitinates IRAK1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30291", "l": "(9Z,12Z)-octadecadienoate + O2 = (9S)-hydroperoxy-(10E,12Z)-octadecadienoate"}, {"i": "EC:1.13.11.58", "l": "\"Linoleate 9S-lipoxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48946", "l": "3-acetyl-3-devinylchlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin] => ADP + bacteriochlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190258", "l": "FGFR2c binds to FGF (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236971", "l": "Peptide loading on MHC class I in phagosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635868", "l": "ub-GLI is degraded by the proteasome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17711", "l": "4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-nonaprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14361", "l": "H2O + O2 + S-prenyl-L-cysteine = 3-methyl-2-butenal + H2O2 + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2213208", "l": "Type X collagen associates with collagen type II fibrils (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.64", "l": "\"Mitochondrial processing peptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.46", "l": "\"Gentamicin 2''-nucleotidyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684882", "l": "CHEK1 is recruited to resected DNA DSBs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21729", "l": "GDP-alpha-D-mannose + H2O + 2 NAD(+) => GDP-alpha-D-mannuronate + 3 H(+) + 2 NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59815", "l": "hexadecanoyl-CoA + N-terminal glycyl-[protein] <=> CoA + H(+) + N-terminal N(6)-hexadecanoylglycyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59768", "l": "hexadecanoyl-CoA + L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] = CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46525", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46405", "l": "2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112727", "l": "Serine phosphorylation of STATs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061663", "l": "NEDD8 ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18882", "l": "ATP + histamine + L-glutamate => ADP + H(+) + N(alpha)-gamma-L-glutamylhistamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610732", "l": "GSK3 phosphorylates p-GLI3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35133", "l": "H(+)(in) + L-alanyl-L-glutamate(in) => H(+)(out) + L-alanyl-L-glutamate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090491", "l": "N-hydroxy-L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27497", "l": "3'-O-methyltricetin + S-adenosyl-L-methionine = 3',5'-di-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63751", "l": "UDP-alpha-D-glucuronate + zolasartan <=> UDP + zolarsartan-2-N-beta-D-glucuronide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23232", "l": "4 [Fe(III)cytochrome c] + hydrazine = 4 [Fe(II)cytochrome c] + 4 H(+) + N2"}, {"i": "EC:1.7.2.8", "l": "\"Hydrazine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43118", "l": "2 [Fe(III)-cytochrome b5] + H2O + N-octanoyl-4-hydroxysphinganine => 2 [Fe(II)-cytochrome b5] + 2 H(+) + N-octanoylsphinganine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682992", "l": "KDM4A,B bind H4K20Me2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956031", "l": "NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14789", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP"}, {"i": "EC:2.4.1.198", "l": "\"Phosphatidylinositol N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445124", "l": "Patched binds Smoothened (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446187", "l": "ALG11 transfers the fourth and fifth Man to the N-glycan precursor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174058", "l": "Degradation of multiubiquitinated Cdh1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15784", "l": "L-tyrosine <=> 3-amino-3-(4-hydroxyphenyl)propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167111", "l": "Extrusion of 5'-end of 30 nt long HIV-1 transcript through the pore in Pol II complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12367", "l": "1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) <=> a quinol + beta-nicotinamide D-riboside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64810", "l": "CoA + H(+) + O-(2-acetamidoethyl)-L-serine => acetyl-CoA + O-(2-aminoethyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042731", "l": "PH domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093331", "l": "Ras:GTP binds p120-RasGAP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187632", "l": "arginine + H2O => ornithine + urea (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799097", "l": "ATM phosphorylates ZNF420 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55054", "l": "CoA + H(+) + pentanoate => H2O + pentanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57103", "l": "S-methyl-5-thio-D-ribulose 1-phosphate <=> S-methyl-1-thio-D-xylulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6810376", "l": "ING2 binds PI5P (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52285", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => 11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388855", "l": "Prolactin-releasing hormone receptor binds PRH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22082", "l": "H2O + NAD(+) + quinoline-2,8-diol => H(+) + NADH + O2 + quinolin-2-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63714", "l": "2 [Fe(III)-cytochrome b5] + a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl derivative + 2 H2O => 2 [Fe(II)-cytochrome b5] + a (7Z,10Z,13Z,16Z)-docosatetraenoyl derivative + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28776", "l": "dinoflagellate luciferin + O2 => H(+) + H2O + hnu + oxidized dinoflagellate luciferin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43081", "l": "O2 + oleanolic aldehyde + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + oleanolate + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44866", "l": "a 1,2-diacylglycerol + a fatty acid + H(+) => a triacyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928576", "l": "RHOA:GTP binds ROCK, activating it (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102135", "l": "(22S)-22-hydroxy-campest-4-en-3-one C-23 hydroxylase activity"}, {"i": "MetaCyc:RXN-11530"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53734", "l": "2-hydroxy-7,8-dihydropteroate + diphosphate => (7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminosalicylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20513", "l": "2-aryl-2-methylmalonate + H(+) = 2-arylpropionate + CO2"}, {"i": "EC:4.1.1.76", "l": "\"Arylmalonate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64379", "l": "8 A + a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid <=> a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 8 AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607724", "l": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9733969", "l": "Bile salts dissociate from FABP6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51662", "l": "an N-(2-hydroxyacyl)-sphinganine + H2O + NADP(+) => an N-(1,2-saturated acyl)sphinganine + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928607", "l": "p-EPHs bind VAV2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707516", "l": "FeHM dissociates from MetHb (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605797", "l": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322429", "l": "XIAP monoubiquinates TLE (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694441", "l": "CSNK1D phosphorylates SEC23 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65406", "l": "butyl hexanoate + CoA => butan-1-ol + hexanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299318", "l": "Activation of TASK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66219", "l": "asc-C7-CoA + O2 <=> asc-DeltaC7-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617408", "l": "GLI3R binds the GLI1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615801", "l": "MECP2 binds IRAK1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27714", "l": "GMP + H2O = guanosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28464", "l": "pyridoxal(out) => pyridoxal(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665727", "l": "FMNL2 binds CDC42:GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16719", "l": "cholate + FADH2 => deoxycholate + FAD + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-994148", "l": "LRRC16A binds F-actin capping protein (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72127", "l": "Formation of the Spliceosomal B Complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14995", "l": "a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+) => acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24413", "l": "4-(hydroxymethyl)benzenesulfonate + NAD(+) => 4-formylbenzenesulfonate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173725", "l": "C9 binds C5b:C6:C7:C8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5333678", "l": "CPNEs bind PL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102096", "l": "decaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate:dTDP-alpha-L-rhamnose rhamnosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52423", "l": "O-phospho-L-serine + thiosulfate <=> phosphate + S-sulfo-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60759", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-cinerolone <=> cinerin I + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33603", "l": "H(+) + N-hexacosanoylsphinganine + NADPH + O2 = H2O + N-(2-hydroxyhexacosanoyl)-sphinganine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58069", "l": "O2 + trans-isoeugenol => acetaldehyde + vanillin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003853", "l": "2-methylacyl-CoA dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24440", "l": "ATP + H2O + phosphate(out) = ADP + H(+) + 2 phosphate(in)"}, {"i": "EC:7.3.2.1", "l": "\"ABC-type phosphate transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51591", "l": "isopyridoxal + NAD(+) <=> 5-pyridoxolactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801666", "l": "PLK2 phosphorylates CENPJ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5213466", "l": "RIPK3 is phosphorylated (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25373", "l": "3-(1-carboxyvinyloxy)anthranilate + FMNH2 => (2S)-2-amino-4-deoxychorismate + FMN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42973", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a cardiolipin + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21717", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + (S)-mandelate + O2 => (6R)-L-erythro-6,7-dihydrobiopterin + (S)-4-hydroxymandelate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624272", "l": "MMPs cleave HB-EGF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9006850", "l": "IL21 receptor JAK phosphorylation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31015", "l": "H(+) + indole-3-carboxylate = CO2 + indole"}, {"i": "EC:4.1.1.92", "l": "\"Indole-3-carboxylate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27743", "l": "2'-deoxyadenosine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + adenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5607734", "l": "PKC-delta translocates to plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663252", "l": "NR1D1 (REV-ERBA) binds heme, the ELOVL3 gene, and recruits corepressors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50855", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17935", "l": "a 7-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine => a 7-hydroxyisoflavone + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048307", "l": "ferredoxin-nitrite reductase activity"}, {"i": "MetaCyc:FERREDOXIN--NITRITE-REDUCTASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63319", "l": "(9Z,12Z)-octadecadienoate + O2 <=> 9-hydroperoxy-(10E,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110215", "l": "Cleavage of uracil by UNG glycosylase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102986", "l": "trehalose synthase activity"}, {"i": "RHEA:47416", "l": "an NDP-alpha-D-glucose + D-glucose = a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62800", "l": "2 7-demethylsiderin + NADPH + O2 = 2 H2O + NADP(+) + orlandin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68826", "l": "Free CDT1 associates with CDC6:ORC:origin complexes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12165", "l": "3'-phosphoadenylyl sulfate + a phenol => a phenyl sulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627369", "l": "SEPT4 binds XIAP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191763", "l": "snRNP:Snurportin complex formation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-181450", "l": "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13678", "l": "D-ribulose 5-phosphate => D-xylulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003960", "l": "NADPH:quinone reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44422", "l": "a 1-acyl-sn-glycero-3-phosphate + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28812", "l": "2,3-dioxo-L-gulonate(in) + Na(+)(in) => 2,3-dioxo-L-gulonate(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50815", "l": "androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43647", "l": "H(+) + malonyl-[ACP] + tetradecanoyl-CoA <=> 3-oxohexadecanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28247", "l": "(R)-pantoate + ATP => (R)-4-phosphopantoate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791083", "l": "Expression of Sec12 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375138", "l": "CDO binds BOC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047116", "l": "1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432909", "l": "Interaction of Plectin with Integrin beta 4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021596", "l": "Membrane estrogen receptors bind SRC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164616", "l": "Biogenesis and assembly of the telomerase RNP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29634", "l": "alpha-maltotetraose + H2O <=> alpha-D-glucose + alpha-maltotriose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010293", "l": "abscisic aldehyde oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30724", "l": "A + 2 ADP + H(+) + NH4(+) + 2 phosphate => AH2 + 2 ATP + H2O + hydroxylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47449", "l": "(5Z)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395412", "l": "Phosphorylation of SYK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382058", "l": "Nck binds to the active PDGF receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70971", "l": "citrate <=> isocitrate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728697", "l": "GNAT3 exchanges GDP for GTP in TAS1R2:TAS1R3:sweet compound:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369080", "l": "PRLR binds STAT5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20423", "l": "D-glucose + D-glucose 6-phosphate => alpha-maltose 6'-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391936", "l": "EP1 receptor can bind PGE2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30000", "l": "ATP + H2O + spermidine(out) => ADP + H(+) + phosphate + spermidine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5669250", "l": "PAK1 phosphorylates FLNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209168", "l": "Phosphorylation of SMO by CKIalpha (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64276", "l": "chrysophanol-9-anthrone + O2 = chrysophanol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112755", "l": "SOCS3 binds IL6ST (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45672", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218852", "l": "p-6Y-VEGFR2 binds PI3K (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390649", "l": "CHRM1,3,5 bind acetylcholine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689544", "l": "UCHL5 binds INO80 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877153", "l": "STARD7 binds PC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3149492", "l": "cob(II)alamin dissociates from MMACHC:MMADHC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102064", "l": "gamma-curcumene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9035484", "l": "CysS248-MPST:TXN2 dissociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166119", "l": "First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10370", "l": "dTDP-4-dehydro-6-deoxy-D-galactose + L-glutamate => 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33913", "l": "an alkylamine + glyoxylate + H2O2 => an N-alkylglycine + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57309", "l": "CTP + H(+) + N(5)-phospho-L-glutamine => diphosphate + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57539", "l": "a ribonucleoside 5'-triphosphate + adenosine-5'-diphospho-5'-ribonucleotide-RNA <=> 5'-NTP-ribonucleotide-RNA + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62077", "l": "D-galactose 6-phosphate + NAD(+) => 6-phospho-D-galactono-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357831", "l": "CYLD is phosphorylated by IKK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017044", "l": "melanocyte-stimulating hormone activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102172", "l": "4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40139", "l": "(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102870", "l": "7-hydroxyflavone-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-8355"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000150", "l": "DNA strand exchange activity"}, {"i": "REACT:R-HSA-912458", "l": "Formation of meiotic heteroduplex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035954", "l": "Defective CYP17A1 does not 17-hydroxylate P4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16673", "l": "3-phosphonopyruvate + H2O = H(+) + phosphate + pyruvate"}, {"i": "EC:3.11.1.3", "l": "\"Phosphonopyruvate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8954082", "l": "E2F6 binds the PRC1 complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23234", "l": "4 [Fe(II)cytochrome c] + 4 H(+) + N2 => 4 [Fe(III)cytochrome c] + hydrazine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004756", "l": "selenide, water dikinase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035375", "l": "zymogen binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875443", "l": "USP8 deubiquitinates LRIG1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20613", "l": "3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine = adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004123", "l": "cystathionine gamma-lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48393", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + GDP-beta-L-fucose => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19581", "l": "N(6)-dimethylallyladenine + S-adenosyl-L-methionine = discadenine + H(+) + S-methyl-5'-thioadenosine"}, {"i": "EC:2.5.1.24", "l": "\"Discadenine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64574", "l": "(2Z,6Z)-farnesyl diphosphate + diphosphate => isopentenyl diphosphate + neryl diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102419", "l": "sn-2-glycerol-3-phosphate omega-OH-C22:0-CoA acyl transferase activity"}, {"i": "RHEA:33559", "l": "an acyl-CoA + sn-glycerol 3-phosphate = a 2-acyl-sn-glycerol 3-phosphate + CoA"}, {"i": "EC:2.3.1.198", "l": "\"Glycerol-3-phosphate 2-O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58080", "l": "1-docosanoylglycerol + H2O = docosanoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49279", "l": "CTP + phytyl phosphate <=> CDP + phytyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57434", "l": "1,2,3-trihydroxybenzene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => 3-methoxycatechol + O2 + reduced [NADH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13701", "l": "acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine"}, {"i": "EC:2.3.1.31", "l": "\"Homoserine O-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008709", "l": "cholate 7-alpha-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43657", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CTP => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48068", "l": "ganglioside GM2 (d18:1(4E)) + H2O = ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62191", "l": "9alpha-copalyl diphosphate <=> diphosphate + syn-isopimara-7,15-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25409", "l": "ADP-alpha-D-glucose + D-glucose => ADP + alpha,alpha-trehalose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34328", "l": "4-nitrophenol + H(+) + NADPH + O2 => 1,4-benzoquinone + H2O + NADP(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24406", "l": "acetoacetate + acetyl-CoA => (3S)-hydroxy-3-methylglutaryl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0003845", "l": "11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47612", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + H(+) + UDP"}, {"i": "EC:2.4.1.337", "l": "\"1,2-diacylglycerol 3-alpha-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975857", "l": "TRAF6 binds to hp- IRAK1 or p-IRAK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678854", "l": "S1PR1 binds S1PR1 agonists (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42594", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707856", "l": "PGRMC2:Hemes dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0008187", "l": "poly-pyrimidine tract binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16637", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP"}, {"i": "EC:2.4.1.16", "l": "\"Chitin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-398185", "l": "LARG binds plexin B1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0070854", "l": "myosin VI heavy chain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21678", "l": "(R)-lavandulyl diphosphate + diphosphate => 2 dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848818", "l": "PTK6 phosphorylates CBL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34504", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-epi-alpha-bisabolol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031837", "l": "substance K receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156678", "l": "Activation of Cdc25C (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981497", "l": "ST3GAL1-4 can add a sialic acid to the T antigen at the alpha 3 position (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.13", "l": "\"Protein kinase C\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168886", "l": "Hemopexin binds Hemes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27862", "l": "3'-GMP + H2O = guanosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37932", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => (10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701569", "l": "ALK- and STAT3-dependent HIF1A gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12387", "l": "5,6-dihydrouracil + O2 <=> H2O2 + uracil"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950681", "l": "Expression of Lamin-B1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55025", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] => (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46442", "l": "A + a (8E,10E,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33717", "l": "2-hydroxyoctadecanal + phosphoethanolamine => 4-hydroxyeicosasphinganine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9656244", "l": "DRD2 binds DA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64936", "l": "dGTP + H2O = dGDP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2167942", "l": "Collagen type XIII ectodomain shedding (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168888", "l": "Alpha1-Microglobulin binds heme (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62895", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA <=> 6 CO2 + 7 CoA + 2 H2O + nor-toralactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798749", "l": "Exocytosis of specific granule lumen proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15422", "l": "a long-chain fatty acid + ATP + CoA => a long-chain fatty acyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11621", "l": "H2O + L-2-amino-4-chloropent-4-enoate => 2-oxopent-4-enoate + chloride + H(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41958", "l": "cytidine 2'-phosphate + H(+) => 2',3'-cyclic CMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211968", "l": "CYP2W1 oxidises INDOL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805620", "l": "KAT6A and PML bind TP53 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64012", "l": "acetyl-CoA + AH2 + 3 malonyl-CoA + 3 S-adenosyl-L-methionine = A + 3 CO2 + 4 CoA + fumigermin + H2O + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392195", "l": "Gi activation by P2Y purinoceptor 12 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868666", "l": "CDK5:p25 phosphorylates JUN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40362", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + ATP <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.38"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19816", "l": "a 2-oxocarboxylate + L-asparagine <=> 2-oxosuccinamate + an L-alpha-amino acid"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015607", "l": "ABC-type fatty-acyl-CoA transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671876", "l": "Phosphorylated STAT5 Dissociates from Leptin Receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22229", "l": "H(+) + NADH + presqualene diphosphate => diphosphate + NAD(+) + squalene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46632", "l": "7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + NADPH = 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13787", "l": "H2O + itaconyl-CoA => citramalyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1640164", "l": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51631", "l": "formate + H(+) + UTP <=> CO2 + dUTP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863494", "l": "ASICs bind STOML3, (STOM) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.59", "l": "\"Tryptase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786421", "l": "CHIA hydrolyses chitin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53389", "l": "5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + UDP-alpha-D-glucuronate => 5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46791", "l": "a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(6Z,9Z,12Z,15Z)-octadectetraenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052819", "l": "heteroglycan 2-alpha-mannosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73577", "l": "CAD hexamer transforms L-Gln to CAP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33338", "l": "1,2-dioctadecanoyl-sn-glycero-3-phosphate + H2O <=> 1,2-dioctadecanoyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18751", "l": "[protein]-disulfide + H(+) + NADH => [protein]-dithiol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810392", "l": "TMEM55B translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015155", "l": "lactose transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63299", "l": "an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3-carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53550", "l": "Delta(12)-prostaglandin J2 => prostaglandin J2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070728", "l": "leucine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26279", "l": "Co-precorrin-5A + H(+) + S-adenosyl-L-homocysteine => Co-precorrin-4 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56278", "l": "3'-L-prolyl-AMP + diphosphate => ATP + L-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47757", "l": "guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25911", "l": "an alditol + O2 <=> an aldose + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22887", "l": "glyoxylate + L-methionine <=> 4-methylsulfanyl-2-oxobutanoate + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29392", "l": "GTP + H2O => diphosphate + GMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786190", "l": "CMBL hydrolyses OM to OLMS (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46053", "l": "U6 RNA 3'-terminal UU => U6 RNA 3'-terminal uridine 2',3'-cyclic phosphate + uridine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36870", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209891", "l": "Dopamine is oxidised to noradrenaline (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18786", "l": "A + gibberellin A12 aldehyde + H2O => AH2 + gibberellin A12 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483116", "l": "GPCho is hydrolyzed to Cho and G3P by GPCPD1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29213", "l": "H(+)(in) + inosine(out) => H(+)(out) + inosine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17039", "l": "H(+) + indole-3-acetaldehyde + NADPH => indole-3-ethanol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60517", "l": "L-tryptophan => D-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.16"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009910", "l": "IL37(?-218) binds p-S423,S425-SMAD3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047118", "l": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66099", "l": "3-phenylpyruvate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19789", "l": "4-(dimethylamino)azobenzene + H2O + NADP(+) = 4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH"}, {"i": "EC:1.7.1.11", "l": "\"4-(dimethylamino)phenylazoxybenzene reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53899", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc-R + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11628", "l": "a 2-oxocarboxylate + H(+) = an aldehyde + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10950", "l": "ADP + D-glucosamine 6-phosphate + H(+) => ATP + D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24787", "l": "3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+) => 3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44292", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CDP-ethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6783880", "l": "PIPOX oxidises PPCA to P6C (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12767", "l": "acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44485", "l": "3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52993", "l": "[deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + [eIF5A protein]-L-lysine => [deoxyhypusine synthase]-L-lysine + [eIF5A protein]-N-(4-aminobutylidene)-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32275", "l": "4-(phosphooxy)-L-threonine + NAD(+) = 3-amino-2-oxopropyl phosphate + CO2 + NADH"}, {"i": "EC:1.1.1.262", "l": "\"4-hydroxythreonine-4-phosphate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1878002", "l": "XYLTs transfer Xyl to core protein (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218820", "l": "Src kinases phosphorylate VAV (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48207", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentadecanoyl-CoA <=> (2E)-pentadecenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465940", "l": "atRAL is reduced to atROL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507870", "l": "Aquaporins passively transport water out of cells (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53757", "l": "allodeoxycholoyl-CoA + cholate => allodeoxycholate + choloyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41928", "l": "(2E)-octadecenoyl-[ACP] + H(+) + NADPH = NADP(+) + octadecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40725", "l": "(9E)-octadecenoate + CoA + H(+) => (9E)-octadecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193636", "l": "p75NTR interacts with the NOGO receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46395", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4beta,24S-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247837", "l": "WNT ligands traffic to the Golgi (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183067", "l": "Localization of CBL:GRB2 to the membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0005227", "l": "calcium activated cation channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351901", "l": "Caspase-mediated cleavage of MST3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9661432", "l": "BIL binds ALB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.23"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45470", "l": "(Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa-cis-undecaprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9613497", "l": "Unwinding DNA for the nascent transcript (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391933", "l": "EP3 receptor can bind PGE2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31293", "l": "FADH2 + oxaloacetate => (S)-malate + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14425", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)"}, {"i": "EC:2.7.1.68", "l": "\"1-phosphatidylinositol-4-phosphate 5-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1254251", "l": "ERBB4s80 binds YAP1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56607", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) <=> 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47203", "l": "(24S)-7alpha-dihydroxycholesterol + NAD(+) <=> (24S)-7alpha,24-dihydroxycholest-4-en-3-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798373", "l": "MDM2 ubiquitinates DYRK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444171", "l": "Receptor FFAR2 binds carboxylates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61203", "l": "acetyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] <=> CoA + myricetin 3-O-[(6-O-acetyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30051", "l": "fluoroacetate + H2O = fluoride + glycolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29560", "l": "H2O + UDP-alpha-D-glucuronate => 1-phospho-alpha-D-glucuronate + 2 H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42843", "l": "acetyl-CoA + 6 H(+) + 5 malonyl-CoA + 2 NADPH <=> 2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 3 H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444047", "l": "Receptor FFAR3 binds carboxylates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39188", "l": "(3R)-hydroxydocosanoyl-CoA => (2E)-docosenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357845", "l": "RIPK1 is deubiquitinated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44852", "l": "(5Z)-tetradecenoyl-CoA + (R)-carnitine = CoA + O-(5Z)-tetradecenoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44717", "l": "A + all-trans-4,4'-diapolycopen-4-al + H2O => AH2 + all-trans-4,4'-diapolycopen-4-oate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675790", "l": "MTORC1 dissociates from ULK complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45046", "l": "2 [Fe(III)cytochrome c] + H2O + nitrite => 2 [Fe(II)cytochrome c] + H(+) + nitroxyl + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50109", "l": "hexadecanoyl-CoA + taurine => CoA + H(+) + N-hexadecanoyl-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.42"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53703", "l": "2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22021", "l": "ATP + H2O + molybdate(out) => ADP + H(+) + molybdate(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32754", "l": "choline(out) <=> choline(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56356", "l": "3-bromo-4-hydroxybenzoate + bromide + 3 H(+) + NADPH + O2 = 2,4-dibromophenol + CO2 + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000112", "l": "Endosomal TCII:Cbl translocates to lysosome (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12113", "l": "indole-3-pyruvate + S-adenosyl-L-methionine => (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111962", "l": "PDE4A,C,D hydrolyse cAMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48043", "l": "globoside Gb4Cer + H2O <=> globoside Gb3Cer + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635843", "l": "GLI translocates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624494", "l": "RAF1 binds p21 RAS:GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10633", "l": "D-mannonate + NAD(+) => D-mannuronate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610752", "l": "GLI3R translocates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43333", "l": "adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13265", "l": "1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine = 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine"}, {"i": "EC:2.1.4.2", "l": "\"Scyllo-inosamine-4-phosphate amidinotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64934", "l": "dGMP + 2 H(+) + 2 phosphate => dGTP + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34630", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63904", "l": "2 3-phenylpyruvate + H(+) = H2O + phenguignardate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549475", "l": "Expression of NR1D1 (REV-ERBA) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50768", "l": "4-methylamino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine = anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043996", "l": "histone acetyltransferase activity (H4-K8 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372843", "l": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43374", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + dTDP + H(+) => an N-acylsphing-4-enine + dTDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52302", "l": "(12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426152", "l": "SREBP1A,2 binds the IDI1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9670014", "l": "Factor VIIIa dissociates  (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24965", "l": "calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => calcitetrol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22698", "l": "A + H2O + testololactone => AH2 + androst-4-ene-3,17-dione + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17097", "l": "3-phenylpyruvate = enol-phenylpyruvate"}, {"i": "EC:5.3.2.1", "l": "\"Phenylpyruvate tautomerase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047196", "l": "long-chain-alcohol O-fatty-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43846", "l": "(3beta)-hydroxy-cholest-5-en-26-oate + H2O + NADP(+) => (3beta)-hydroxy-cholest-5-en-26-al + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51753", "l": "a 2-acylphloroglucinol + dimethylallyl diphosphate => a 2-acyl-4-prenylphloroglucinol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0051139", "l": "metal ion:proton antiporter activity"}, {"i": "REACT:R-HSA-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51008", "l": "2 [Fe(III)cytochrome cL] + methanol = 2 [Fe(II)cytochrome cL] + formaldehyde + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-164617", "l": "Elongation of Extended Telomeric Chromosome End (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140851", "l": "fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9660557", "l": "RAS:GTP binds RAL GDS proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27996", "l": "D-ribose + xanthine => H2O + xanthosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47163", "l": "4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) <=> 4-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19139", "l": "6beta-hydroxyestradiol-17beta + A + H2O => 17beta-estradiol + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65786", "l": "3-(4-chlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + monuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685230", "l": "CHEK1 phosphorylates RAD51 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56025", "l": "H2O + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2) => beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59316", "l": "D-cellobiose + O2 = D-cellobiono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40717", "l": "1-hexadecanoylglycerone 3-phosphate + CoA => dihydroxyacetone phosphate + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.55"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5432849", "l": "S100A8:S100A9 binds TLR4:LY96 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5082356", "l": "HSF1-mediated gene expression (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-444433", "l": "Cho transports from the extracellular space to the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102890", "l": "naringenin chalcone 4'-O-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15822", "l": "2 A + glycine => 2 AH2 + CO2 + hydrogen cyanide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43921", "l": "(25R)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446322", "l": "PARVA associates with Paxillin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31657", "l": "5-dehydro-4-deoxy-2-O-sulfo-D-glucuronate + N-acetyl-beta-D-galactosamine => 4-deoxy-Delta(4)-beta-D-GlcpA2S-(1->3)-beta-D-GalpNAc + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19347", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate => (6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58230", "l": "H(+) + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide => L-asparaginyl-[protein] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48337", "l": "a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose => a neolactoside III(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250280", "l": "ROS oxidize thioredoxin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682992", "l": "KDM4A,B bind H4K20Me2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.15.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8942302", "l": "MMP13 cleaves OPTC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16723", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420-(gamma-Glu)(n) => 5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60837", "l": "a 5'-end diphospho-adenosine in mRNA + GTP + H(+) => a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787737", "l": "CSF3R binds CSF3 dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58381", "l": "NADP(+) + nonan-1-ol => H(+) + NADPH + nonanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168459", "l": "Lyn activates ERK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27270", "l": "CoA + hexadecanal + NADP(+) = H(+) + hexadecanoyl-CoA + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39471", "l": "(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32115", "l": "2-oxoglutarate + DIBOA beta-D-glucoside + O2 = CO2 + succinate + TRIBOA beta-D-glucoside"}, {"i": "EC:1.14.11.59", "l": "\"2,4-dihydroxy-1,4-benzoxazin-3-one-glucoside dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199062", "l": "KLRC1:KLRD1 heterodimer interacts with HLA-E (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-381087", "l": "Dimerization of PERK (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65519", "l": "5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O <=> NH4(+) + pre-mycofactocin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47275", "l": "monoanhydrobacterioruberin <=> bisanhydrobacterioruberin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39018", "l": "22-oxodocosanoate + H2O + NAD(+) <=> docosanedioate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093332", "l": "p-EPHB phosphorylates SDC2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48433", "l": "ATP + N(6)-D-ribulosyl-L-lysyl-[protein] => ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29029", "l": "2 H(+)(out) + L-glutamate(out) => 2 H(+)(in) + L-glutamate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158399", "l": "kallikrein binds SERPING1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18131", "l": "a 2-oxocarboxylate + 2 H(+) + NADPH => 2-oxoaldehyde + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17365", "l": "ATP + H2O + Mn(2+)(out) = ADP + H(+) + Mn(2+)(in) + phosphate"}, {"i": "EC:7.2.2.5", "l": "\"ABC-type Mn(2+) transporter\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033811", "l": "flavonol-3-O-triglucoside O-coumaroyltransferase activity"}, {"i": "MetaCyc:2.3.1.173-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047418", "l": "phthalyl amidase activity"}, {"i": "RHEA:18297", "l": "a phtalamide + H2O = a primary amine + phthalate"}, {"i": "EC:3.5.1.79", "l": "\"Phthalyl amidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674531", "l": "AAMP binds EGFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-372449", "l": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74742", "l": "Phosphorylation of SHC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-688985", "l": "K63 polyubiquitinated RIP2 associates with the TAK1 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-947531", "l": "Molybdenum ion transfer onto molybdopterin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25603", "l": "2-(2-methylsulfanyl)ethylmalate + CoA + H(+) => 4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687465", "l": "HSV1 RIR1 binds RIPK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247844", "l": "WNT ligands traffic to the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12690", "l": "2 mycothiol + NAD(+) => H(+) + mycothione + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57622", "l": "H(+) + 2 H2O + ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase] => dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75862", "l": "Fall Back to Closed Pre-initiation Complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044318", "l": "L-aspartate:fumarate oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782820", "l": "USP17 deubiquitinates SUDS3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432121", "l": "LDL binds to LRP8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001222", "l": "transcription corepressor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13907", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156678", "l": "Activation of Cdc25C (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53036", "l": "4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61469", "l": "a cytidine in tRNA + S-adenosyl-L-methionine => a 5-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9737780", "l": "MTTP binds lomitapide (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15412", "l": "1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine <=> 1-O-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174097", "l": "Association of Emi1 with Cdh1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102694", "l": "kinetin UDP glycosyltransferase activity"}, {"i": "MetaCyc:RXN-4732"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15790", "l": "L-xylose + NADP(+) => H(+) + L-xylono-1,4-lactone + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59217", "l": "(indol-3-yl)acetate + H(+) => CO2 + skatole"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.63"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043878", "l": "glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428888", "l": "Phosphorylation of ROBO1 by ABL kinase (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354097", "l": "Activation of Talin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27980", "l": "alpha-D-mannose 1-phosphate + GMP + 2 H(+) => GDP-alpha-D-mannose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013021", "l": "GDIs block activation of RHOB (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.73"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24419", "l": "2,4'-dihydroxyacetophenone + O2 <=> 4-hydroxybenzoate + formate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43318", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948230", "l": "P3HB binds 4-Hyp-collagen propeptides (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008145", "l": "phenylalkylamine binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018607", "l": "1-indanone monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14135", "l": "16-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64851", "l": "(3Z)-hex-3-en-1-ol + benzoyl-CoA <=> (3Z)-hex-3-en-1-yl benzoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36277", "l": "3-methylxanthine + formaldehyde + H2O + NADP(+) => H(+) + NADPH + O2 + theophylline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20173", "l": "H(+) + NADH + O2 + tetradecanoyl-CoA = (11E)-tetradecenoyl-CoA + 2 H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483077", "l": "PE transports from the mitochondrial membrane to the ER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33759", "l": "a 3-oxo-fatty acyl-CoA + H(+) + NADPH = a 3-hydroxy-fatty acyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730904", "l": "Auto-ubiquitination of TRAF6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59831", "l": "H2O + S-inosyl-L-homocysteine <=> inosine + L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36348", "l": "N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine => 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44777", "l": "2-demethylmenaquinol-6 + S-adenosyl-L-methionine => H(+) + menaquinol-6 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004001", "l": "adenosine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24255", "l": "H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate <=> 2 ADP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592316", "l": "Initial activation of proMMP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35538", "l": "cyclo(L-phenylalanyl-L-leucyl) + O2 <=> cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033809", "l": "anthocyanin 6''-O-malonyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654774", "l": "Transcription of PPP1R15A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48806", "l": "(5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4570528", "l": "SUMOylation of XPC with SUMO1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008043", "l": "MAPK8 phosphorylation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956639", "l": "RUNX1 binds YAP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59733", "l": "biotinyl-5'-AMP + L-lysyl-[protein] => AMP + 2 H(+) + N(6)-biotinyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604360", "l": "Initial activation of proMMP2 by MMP14 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53620", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (-)-spiroviolene + diphosphate"}, {"i": "EC:4.2.3.158", "l": "\"(-)-spiroviolene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25057", "l": "(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 <=> (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23434", "l": "(4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49186", "l": "8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + CO2 + methanol => chlorophyllide a + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29570", "l": "2 chloride(in) + H(+)(out) <=> 2 chloride(out) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33748", "l": "a 1-acyl-sn-glycerol + ATP => a 1-acyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46373", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54068", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = diphosphate + sesterfisherol"}, {"i": "EC:4.2.3.176", "l": "\"Sesterfisherol synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016153", "l": "urocanate hydratase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034937", "l": "perchlorate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938773", "l": "RNF144A polyubiquitinates PRKDC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55188", "l": "5-methyluridine(54) in tRNA + ATP + hydrogen sulfide = 5-methyl-2-thiouridine(54) in tRNA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42459", "l": "4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol <=> 5alpha-cholesta-8,24-dien-3beta-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952069", "l": "HDAC4 deacetylates RUNX3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12283", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694792", "l": "nsp12 misincorporates a nucleotide in nascent RNA minus strand (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29741", "l": "ADP + beta-maltose(in) + H(+) + phosphate => ATP + beta-maltose(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73729", "l": "Formation of SL1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22413", "l": "anthranilate + ATP => diphosphate + N-adenylylanthranilate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34496", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24066", "l": "H(+) + 2 H2O + porphobilinogen => 2 5-aminolevulinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168871", "l": "Fusion of vesicle containing the HA trimer, NA tetramer and M2 tetramer to the Golgi apparatus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806831", "l": "CYB5Rs reduce MetHb to HbA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63285", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39414", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA <=> (2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49371", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+) <=> 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51304", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate = (13R)-hydroperoxy-(9Z,11E)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39129", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADH => (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37164", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50010", "l": "4-hydroxy-6-methylpretetramide + H2O + NADP(+) => 6-methylpretetramide + 2 H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36693", "l": "CoA + H(+) + N-octadecanoylsphing-4-enine => octadecanoyl-CoA + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60283", "l": "L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16548", "l": "formyl-CoA + oxalate <=> formate + oxalyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64634", "l": "butyl acetate + CoA => acetyl-CoA + butan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60022", "l": "diphosphate + sesquisabinene A => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696268", "l": "RND3 binds effectors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197958", "l": "FPGS-2 transforms THF to THFPG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.36"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70241", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61410", "l": "ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysine => ATP + N(6)-(D-erythrulosyl)-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865276", "l": "PDGF-AB clevage by Furin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003810", "l": "protein-glutamine gamma-glutamyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28539", "l": "ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP + H(+) + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022893", "l": "low-affinity tryptophan transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694409", "l": "Nucleotide exchange on RAB1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37313", "l": "ADP + glycyl-L-glutamine(in) + H(+) + phosphate => ATP + glycyl-L-glutamine(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41321", "l": "1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 2-acetyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34915", "l": "D-galactose(in) = D-galactose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1974676", "l": "Beta defensin 103 activates TLR1:TLR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850945", "l": "Casein kinase II phosphorylates PTEN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112037", "l": "Inactivation of PLC beta (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046101", "l": "Peroxisomal beta-oxidation of tetracosapentaenoyl-CoA to Docosapentaenoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696357", "l": "LAIR2 binds collagen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50223", "l": "(S)-demethyl-4-deoxygadusol <=> (R)-demethyl-4-deoxygadusol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032867", "l": "L-arabinose:NADP reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29287", "l": "2 H(+)(in) + L-aspartate(in) = 2 H(+)(out) + L-aspartate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2530584", "l": "CREM (CREMP) binds to surface-bound C3b or C4b (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59391", "l": "a fatty acid ester + H2O <=> a fatty acid + an aliphatic alcohol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21233", "l": "L-histidine => NH4(+) + trans-urocanate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209891", "l": "Dopamine is oxidised to noradrenaline (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56813", "l": "2-oxoglutarate + chloride + H(+) + L-threonyl-[peptidyl-carrier protein] + O2 => 4-chloro-L-threonyl-[peptidyl-carrier protein] + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787566", "l": "PUS1 isoform 1 transforms uridine-27, uridine-28 yielding pseudouridine in tRNA(Lys,Ser) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45180", "l": "2 (E)-4-coumaroyl-CoA + spermidine = 2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine"}, {"i": "EC:2.3.1.249", "l": "\"Spermidine dicoumaroyl transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1454916", "l": "The ABCC family mediates organic anion transport (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51084", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40561", "l": "dTDP-N-hydroxy-beta-L-evernosamine + H2O + NADP(+) => dTDP-beta-L-evernosamine + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-532549", "l": "MPI isomerises Fru6P to Man6P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858346", "l": "AMHR2 binds AMH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55780", "l": "all-trans-5,6-epoxyretinoate + UDP-alpha-D-glucuronate = all-trans-5,6-epoxyretinoyl-1-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57574", "l": "7-deoxyloganetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7-deoxyloganetic aldehyde + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102276", "l": "2-oxoglutarate oxygenase/decarboxylase (ethylene-forming) activity"}, {"i": "RHEA:31523", "l": "2-oxoglutarate + 2 H(+) + O2 = 3 CO2 + ethene + H2O"}, {"i": "EC:1.13.12.19", "l": "\"2-oxuglutarate dioxygenase (ethene-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59510", "l": "S-(2-succinyl)-L-cysteinyl-[protein] => fumarate + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31756", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA + H2O => 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-917841", "l": "Acidification of Tf:TfR1 containing endosome (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45336", "l": "(9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine = [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA"}, {"i": "EC:2.3.1.250", "l": "\"[Wnt protein] O-palmitoleoyl transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62821", "l": "1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391941", "l": "BLT receptors can bind LTB4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35556", "l": "cyclo(L-leucyl-L-leucyl) + 4 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] + pulcherriminic acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50337", "l": "O2 + reduced [NADPH--hemoprotein reductase] + triacontanoate => H(+) + H2O + omega-hydroxy-triacontanoate + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9646468", "l": "mTORC1 binds RHEB:GTP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102974", "l": "hydroxyversicolorone reductase activity"}, {"i": "MetaCyc:RXN-9489"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351207", "l": "Spermine  => N-acetylated spermine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018127", "l": "NAD(P)-serine ADP-ribosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606160", "l": "p-PIK3AP1 (p-BCAP) binds PIK3CD:PIK3R1 (PI3K delta) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15486", "l": "(1R,2S)-homoisocitrate => cis-homoaconitate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58309", "l": "25-substituted-cholesterol + beta-D-glucosyl-N-(15Z-tetracosenoyl)-sphing-4E-enine => 25-substituted-cholesteryl beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52411", "l": "4-phospho-D-erythronate + NAD(+) <=> CO2 + dihydroxyacetone phosphate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20586", "l": "loganin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + secologanin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62233", "l": "a thymidine(6-4)thymidine in DNA => a thymidine dimer in DNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781953", "l": "YOD1 binds VCP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.203", "l": "\"tRNA (cytosine(34)-C(5))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9038052", "l": "GREB1 binds ESR1:ESTG and co-activators (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168894", "l": "p-STAT5A/B dissociates from the Growth Hormone receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35953", "l": "diphosphate + N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate => (7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21307", "l": "ent-kaur-16-en-19-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-kaur-16-en-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19209", "l": "codeine + NADP(+) = codeinone + H(+) + NADPH"}, {"i": "EC:1.1.1.247", "l": "\"Codeinone reductase (NADPH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177937", "l": "Phosphorylation of EGFR by SRC kinase (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24435", "l": "H2O + oxaloacetate <=> acetate + H(+) + oxalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30954", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> alpha-eudesmol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187828", "l": "Translocation of p21 to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16586", "l": "[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426569", "l": "Interaction of DAP12 and IREM2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798667", "l": "TDH tetramer oxidises L-Thr to 2A-3OB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003961", "l": "O-acetylhomoserine aminocarboxypropyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4332363", "l": "Autophosphorylation and activation of CAMK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55150", "l": "a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + H(+) + NADPH => a [(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684169", "l": "G6B binds PTPN6,PTPN11 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63066", "l": "3 CO2 + 4 CoA + tetraacetate lactone => acetyl-CoA + 3 H(+) + 3 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433451", "l": "JAK2 binds to p-KIT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31699", "l": "4 H(+) + 2 O2 + pentalenene + 4 reduced [2Fe-2S]-[ferredoxin] = 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al"}, {"i": "EC:1.14.15.32", "l": "\"Pentalenene oxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44618", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+) => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981931", "l": "RAC1 and CDC42 activate PAK2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031885", "l": "type 1 member 2 taste receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36823", "l": "1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol = CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate"}, {"i": "EC:2.7.8.39", "l": "\"Archaetidylinositol phosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008036", "l": "diuretic hormone receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64980", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38963", "l": "ATP + H2O + leukotriene C4(in) = ADP + H(+) + leukotriene C4(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1299338", "l": "Activation of TRESK (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67078", "l": "H(+) + N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine => L-histidyl-[protein] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30476", "l": "H2O + oroxylin A 7-O-beta-D-glucuronate => D-glucuronate + H(+) + oroxylin A"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018593", "l": "4-chlorophenoxyacetate monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4717461", "l": "PIAS1,2-2 SUMOylate PPARG with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-555065", "l": "Formation of clathrin coated vesicle (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51726", "l": "adenosine 5'-tetraphosphate + ADP + 2 H(+) => H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034534", "l": "1-methylnaphthalene hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018480", "l": "5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626681", "l": "Recruitment of transition zone proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-688136", "l": "TNFAIP3 (A20) deubiquitinates RIP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12061", "l": "acetyl-CoA + 5 H(+) + 6 malonyl-CoA => 3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + 6 CO2 + 7 CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45435", "l": "H2O + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> H(+) + N-(9Z-octadecenoyl) ethanolamine + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11755", "l": "acetylsalicylate + H2O <=> acetate + H(+) + salicylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15400", "l": "dichloromethane + H2O <=> 2 chloride + formaldehyde + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004017", "l": "adenylate kinase activity"}, {"i": "RHEA:12973", "l": "AMP + ATP = 2 ADP"}, {"i": "EC:2.7.4.3", "l": "\"Adenylate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20989", "l": "ATP + 2 H2O => AMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174931", "l": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191763", "l": "snRNP:Snurportin complex formation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15517", "l": "H2O + N(2),6-disulfo-D-glucosamine = H(+) + N-sulfo-D-glucosamine + sulfate"}, {"i": "EC:3.1.6.11", "l": "\"Disulfoglucosamine-6-sulfatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296244", "l": "SUCNR1 binds SUCCA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0140294", "l": "NAD DNA ADP-ribosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16463", "l": "ADP + H(+) + phosphate + urate(out) => ATP + H2O + urate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39976", "l": "2-iminobutanoate + H2O => 2-oxobutanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5340226", "l": "CYGB dioxygenates NO (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59280", "l": "L-asparagine = D-asparagine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64119", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18003", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a carboxylate + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46124", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.26", "l": "\"24-hydroxycholesterol 7-alpha-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10315", "l": "H(+) + NADH + O2 + terephthalate <=> (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72621", "l": "Ribosomal scanning  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-517850", "l": "TLR2-1 : TLR1-2 heterodimer binds to its ligand (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83656", "l": "TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12739", "l": "[PrdC protein]-L-selenocysteine/L-cysteine + D-proline => 5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649726", "l": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41214", "l": "(indol-3-yl)acetate + H(+) + NADH + O2 <=> 2-hydroxy-(1H-indol-3-yl)acetate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635843", "l": "GLI translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53785", "l": "beta-muricholate + deoxycholoyl-CoA => beta-muricholoyl-CoA + deoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047646", "l": "alkanal monooxygenase (FMN-linked) activity"}, {"i": "RHEA:17181", "l": "a long-chain fatty aldehyde + FMNH2 + O2 = a long-chain fatty acid + FMN + 2 H(+) + H2O + hnu"}, {"i": "EC:1.14.14.3", "l": "\"Bacterial luciferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2430533", "l": "CDK1 phosphorylates MASTL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112266", "l": "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28163", "l": "cytidine + GTP => CMP + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676599", "l": "sBAFF trimer binds BAFFR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8944454", "l": "mTORC1 phosphorylates MAF1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052933", "l": "alcohol dehydrogenase (cytochrome c(L)) activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047269", "l": "poly(ribitol-phosphate) N-acetylglucosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49828", "l": "(5E)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,5E)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451634", "l": "NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981621", "l": "Neuroglobin:oxygen dissociates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000327", "l": "PLK1 phosphorylates BORA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877369", "l": "RUNX1 and FOXP3 bind the IFNG gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669024", "l": "CD70 binds CD27 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11553", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + H2O => 1-O-alkyl-sn-glycerol + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "75.848614326174683", "identifiers": [{"i": "GO:0009975", "l": "cyclase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39520", "l": "3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018498", "l": "2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050010", "l": "isovitexin beta-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685242", "l": "CHEK1 phosphorylates BRCA2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10417", "l": "fumarate + toluene => 2-benzylsuccinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57654", "l": "CMP + ganglioside GM1alpha + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201622", "l": "Caspase-mediated cleavage of gelsolin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030766", "l": "11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43522", "l": "2,5-dicarboxyfuran + H(+) + H2O2 => 2-carboxy-5-(dihydroxymethyl)furan + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.63", "l": "\"Pseudobaptigenin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804099", "l": "HMGB1 binds LTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51044", "l": "indole-3-pyruvate imine dimer = CO2 + NH4(+) + protodeoxyviolaceinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54418", "l": "campest-4-en-3-one + H(+) + NADPH => 5alpha-campestan-3-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26160", "l": "(S)-2,3-epoxysqualene = thalianol"}, {"i": "EC:5.4.99.31", "l": "\"Thalianol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42877", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => H(+) + N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58998", "l": "H(+) + H2O2 + indole-3-carboxylate => H2O + indole-3-carbaldehyde + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004351", "l": "glutamate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852317", "l": "PLK1 phosphorylates GTSE1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6813626", "l": "LEAP2 binds bacteria (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64592", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61149", "l": "myricetin 3-O-alpha-L-rhamnoside + UDP-alpha-D-glucose => H(+) + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44221", "l": "15-hydroxypentadecanoate + ATP + CoA => 15-hydroxypentadecanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.96.-", "l": "\"With other, known, acceptors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56515", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O <=> 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450088", "l": "GLUT1 tetramer binds 4xATP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392530", "l": "p-S400-Cot phosphorylates NIK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46472", "l": "4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11383", "l": "2-oxoglutarate + [2-(trimethylamino)ethyl]phosphonate + O2 <=> [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5671707", "l": "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801101", "l": "RABGGTA binds RABGGTB (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25535", "l": "ent-copalyl diphosphate <=> diphosphate + ent-cassa-12,15-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016443", "l": "bidentate ribonuclease III activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419490", "l": "Binding of ATP to P2X receptors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008825", "l": "cyclopropane-fatty-acyl-phospholipid synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1168640", "l": "Ubiquitinated IkB is degraded (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59730", "l": "(2S)-ethylmalonyl-CoA => (2R)-ethylmalonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61284", "l": "H2O + L-cystine + O2 = (2R)-2-amino-2-carboxylatoethyl-disulfanyl-oxopropanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665707", "l": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106318", "l": "methane monooxygenase NADPH activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004380", "l": "glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity"}, {"i": "REACT:R-HSA-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635842", "l": "ULK3 phosphorylates GLI (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0072532", "l": "tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210784", "l": "HNF1B-dependent synthesis of HNF6 protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70510", "l": "LDH tetramer oxidises LACT to PYR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58337", "l": "a 4-hydroxynonen-1-ol + NADP(+) => a 4-hydroxynonenal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16961", "l": "epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine"}, {"i": "EC:4.3.2.8", "l": "\"Gamma-glutamylamine cyclotransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016520", "l": "growth hormone-releasing hormone receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57583", "l": "S-methyl-5-thio-D-ribulose 1-phosphate <=> S-methyl-1-thiol-D-ribulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004769", "l": "steroid delta-isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11987", "l": "AH2 + O2 + progesterone <=> A + H2O + testosterone acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70692", "l": "ornithine => putrescine + CO2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36216", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-ethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004415", "l": "hyalurononglucosaminidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928639", "l": "p-EFNB binds GRB4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23154", "l": "a ubiquinol + NAD(+) => a ubiquinone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004152", "l": "dihydroorotate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39353", "l": "(2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H2O => (3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42016", "l": "cortisone + NAD(+) = 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20690", "l": "chlorogenate + H2O => (E)-caffeate + H(+) + L-quinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928604", "l": "SFKs phosphorylate VAV2,3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050075", "l": "maleate hydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045520", "l": "interleukin-24 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849428", "l": "PTPN1 binds PTK6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618559", "l": "EGR2, SOX10 and TEAD1 bind enhancers in the PMP22 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797803", "l": "PTPRD binds SLITRK1-6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17110", "l": "FMNH2 + N-methylnicotinate + O2 => (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FMN + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76031", "l": "2 H2O2 => O2 + 2 H2O (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44231", "l": "9-decenoate + ATP + CoA <=> 9-decenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44088", "l": "ATP + CoA + heptanoate = AMP + diphosphate + heptanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30067", "l": "betaine aldehyde + H2O + NADP(+) = glycine betaine + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50125", "l": "NAD(+) + resolvin D1 => 8-oxoresolvin D1 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35933", "l": "3''-deamino-3''-hydroxykanamycin X + H(+) + UDP => 2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38636", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-217255", "l": "FMO1:FAD N-oxidises TAM (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44232", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5336443", "l": "LIN7, CASK and APBA1 bind (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673223", "l": "FIX(29-461) variant is not activated (factor XIa catalyst) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43080", "l": "O2 + oleanolic aldehyde + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + oleanolate + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18289", "l": "(S,S)-tartrate = H2O + oxaloacetate"}, {"i": "EC:4.2.1.81", "l": "\"D(-)-tartrate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20731", "l": "H2O + L-glutamate + O2 <=> 2-oxoglutarate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683774", "l": "p-T68-CHEK2 dimerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0030556", "l": "rRNA modification guide activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008886", "l": "glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity"}, {"i": "KEGG.REACTION:R01058"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45955", "l": "L-asparaginyl-[protein] + UDP-alpha-D-glucose <=> H(+) + N(4)-(beta-D-glucosyl)-L-asparaginyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371590", "l": "HSP70 binds to HSP40:nascent protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805479", "l": "TP53RK phosphorylates TP53 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61648", "l": "ATP + holo-[non-ribosomal peptide synthase] + salicylate = AMP + diphosphate + salicyl-[non-ribosomal peptide synthase]"}, {"i": "EC:6.2.1.61", "l": "\"Salicylate--[aryl-carrier protein] ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25863", "l": "GTP + H2O <=> 7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50467", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) + 8 malonyl-CoA + 16 NADPH <=> 17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008803", "l": "bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46260", "l": "2 [Fe(II)-cytochrome b5] + an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 H(+) + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45778", "l": "(indol-3-yl)acetate + NH4(+) => (indol-3-yl)acetonitrile + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27754", "l": "H2O + methylglyoxal = (R)-lactate + H(+)"}, {"i": "EC:4.2.1.130", "l": "\"D-lactate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66996", "l": "2-methylpentanoate + ATP + CoA = 2-methylpentanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66110", "l": "(2S)-2-aminobutanoate + 2-oxo-3-sulfanylpropanoate => 2-oxobutanoate + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8979071", "l": "KDM6B binds iron (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32961", "l": "(S)-3-methyl-2-oxopentanoate + H(+) + NADH + NH4(+) => H2O + L-isoleucine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62200", "l": "2 [Fe(III)cytochrome c] + ethanol = 2 [Fe(II)cytochrome c] + acetaldehyde + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004320", "l": "oleoyl-[acyl-carrier-protein] hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635843", "l": "GLI translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19159", "l": "2-dehydro-3-deoxy-D-arabinonate + H2O => D-xylonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451470", "l": "Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43995", "l": "(2E,6E,10E)-geranylgeraniol + H(+) + NADPH + O2 <=> 16-hydroxy-(2E,6E,10E)-geranylgeraniol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63300", "l": "N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25897", "l": "H(+) + malonate => acetate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58192", "l": "dimethylallyl diphosphate + H2O + isopentenyldehydrorhodopin = dihydrobisanhydrobacterioruberin + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56598", "l": "(1S,4S)-5-oxo-1,2-campholide + FMN + H(+) + H2O => (1S,4S)-bornane-2,5-dione + FMNH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30644", "l": "phosphate + S-methyl-5'-thioinosine => hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168166", "l": "NFkB complex is transported from cytosol to nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2197697", "l": "Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66472", "l": "(2Z,6E,10E,14E)-geranylfarnesol = 18-episcalar-17(25)-en-19-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672951", "l": "Inactive RAFs bind YWHAB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63406", "l": "6-chloro-3-hydroxypyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O => 3,6-dichloropyridine-2,5-diol + FADH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44217", "l": "12-hydroxyoctadecanoate + ATP + CoA => 12-hydroxyoctadecanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14071", "l": "5-dehydro-D-fructose + H(+) + NADPH => D-fructose + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12799", "l": "CO2 + H(+) + H2O + scopolamine + succinate => (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5666129", "l": "CDC42:GTP recruits DIAPH2-2 to kinetochores (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425861", "l": "Activation of Protein Kinase C novel isoforms (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37170", "l": "(2E,6E)-farnesol + NAD(+) <=> (2E,6E)-farnesal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2534378", "l": "Hv1 Mediated H+ Permeability (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.16", "l": "\"3-carboxyethylcatechol 2,3-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37187", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3-phosphate = 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31147", "l": "3,4-dihydroxyphenylethyleneglycol + NAD(+) = 3,4-dihydroxymandelaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66733", "l": "ATP + H2O + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(in) => ADP + H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610388", "l": "HCMV translocates from the endosome lumen to the extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24380", "l": "(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)"}, {"i": "EC:2.1.2.9", "l": "\"Methionyl-tRNA formyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50322", "l": "1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64451", "l": "L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202604", "l": "Formation of a heteromeric BMP receptor complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939201", "l": "ESR dimerizes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21471", "l": "dTDP-alpha-D-mycaminose + tylactone <=> 5-O-beta-D-mycaminosyltylactone + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22437", "l": "(2E,6E)-farnesyl diphosphate + H2O => (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11818", "l": "keto-D-fructose 6-phosphate => aldehydo-D-glucose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209891", "l": "Dopamine is oxidised to noradrenaline (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22103", "l": "3,5-dibromo-4-hydroxybenzonitrile + 2 H2O <=> 3,5-dibromo-4-hydroxybenzoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37039", "l": "5 AH2 + 2 H(+) + heme b + 4 O2 = 5 A + delta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O"}, {"i": "RHEA:37363", "l": "5 AH2 + 2 H(+) + heme b + 4 O2 = 5 A + beta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O"}, {"i": "EC:1.14.99.48", "l": "\"Heme oxygenase (staphylobilin-producing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419644", "l": "Transphosphorylation of pLIMK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164423", "l": "PhosphoChREBP (Thr 666)  is exported to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32307", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = H2O + leukotriene A4"}, {"i": "EC:1.13.11.34", "l": "\"Arachidonate 5-lipoxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26492", "l": "a ketone + H(+) + H2O2 + nitrite => a secondary nitroalkane + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23351", "l": "(R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+) <=> (4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229181", "l": "CALM1:Ca2+ binds CNG channel (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42129", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoylsphinganine => a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033901", "l": "ribonuclease V activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68610", "l": "Formation of ORC(2-5) complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534096", "l": "METAP1/2 demethylates GNAT1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353430", "l": "Binding of Pol eta to a DNA template containing a lesion (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626699", "l": "MARK4 binds ODF2 in the centriole (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65112", "l": "2-oxoglutarate + aculene D + O2 = aculene C + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1462003", "l": "HNP1-4 are stored in primary neutrophil granules (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3159259", "l": "MMAA:MUT binds AdoCbl (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-912734", "l": "CBL:CRKL binds RAPGEF1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25905", "l": "futalosine + H2O => dehypoxanthine futalosine + hypoxanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018794", "l": "RHOV binds effectors at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102759", "l": "campestanol hydroxylase activity"}, {"i": "MetaCyc:RXN-773"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49466", "l": "CO2 + resorcinol => 2,6-dihydroxybenzoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981353", "l": "RASA1 stimulates RAS GTPase activity (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611277", "l": "P2RY12 binds P2RY12 antagonists (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139898", "l": "Caspase-8 activates BID by cleavage (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665989", "l": "DIAPH1 binds RHOA:GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170120", "l": "Translocation of Cdc25B to the cytoplasm (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654159", "l": "Activated FGFR2 binds PLCG1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39517", "l": "(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+) => (2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021357", "l": "PRKCI phosphorylates ELF3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58209", "l": "A + dihydroalstonine => AH2 + alstonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40491", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804425", "l": "TP53 binds POU4F2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66635", "l": "L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60883", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50576", "l": "acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29200", "l": "(S)-dihydroorotate + menaquinone-8 => menaquinol-8 + orotate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12005", "l": "indoxyl + UDP-alpha-D-glucose => H(+) + indican + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52631", "l": "an N-fatty-acyl-L-alpha-amino acid + H2O <=> a fatty acid + an L-alpha-amino acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22809", "l": "6-hydroxynicotinate + H2O + O2 => 2,6-dihydroxynicotinate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70982", "l": "Fumarate + H2O <=> (S)-Malate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062061", "l": "TAP complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27336", "l": "6-hydroxynicotinate + 2 H(+) + NADH + O2 <=> 2,5-dihydroxypyridine + CO2 + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42691", "l": "AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide <=> A + ergothioneine + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49766", "l": "ethylenediaminediacetate + FMN + glyoxylate + H(+) + H2O => ethylenediaminetriacetate + FMNH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947499", "l": "Exchange of oxygen with sulfur in MoCo (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24934", "l": "H2O + L-cysteine <=> H(+) + hydrogen sulfide + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809680", "l": "MTMR12 binds MTM1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42432", "l": "3-hydroxy-cis,cis-muconate = maleylacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63519", "l": "biphenyl-2,2',3-triol + H(+) + NADH + O2 <=> biphenyl-2,2',3,3'-tetraol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53346", "l": "H(+) + NADPH + uridine(20a) in tRNA => 5,6-dihydrouridine(20a) in tRNA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34687", "l": "AH2 + N-acyl-15-methylhexadecasphinganine + O2 = A + 2 H2O + N-acyl-15-methylhexadecasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "ic": "63.042556392227013", "identifiers": [{"i": "GO:0030234", "l": "enzyme regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11064", "l": "beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate"}, {"i": "EC:3.1.3.11", "l": "\"Fructose-bisphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17693", "l": "deoxycholoyl-CoA + H2O = CoA + deoxycholate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44186", "l": "2-epi-5-epi-valiolone + phosphate => D-sedoheptulose 7-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36323", "l": "(9Z)-octadecenoyl-CoA + 2 H(+) + 2 NADPH = (9Z)-octadecen-1-ol + CoA + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53185", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O => 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40853", "l": "(2E)-pentadecenoyl-CoA + FADH2 => FAD + H(+) + pentadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23074", "l": "CO2 + H2O + phosphoenolpyruvate => H(+) + oxaloacetate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48429", "l": "1-(9Z,12Z-octadecadienoyl)-glycerol + H2O => (9Z,12Z)-octadecadienoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42128", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850818", "l": "SPINK9 binds KLK5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51442", "l": "(11S)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10171", "l": "15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin] <=> biliverdin IXalpha + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408509", "l": "Sec-tRNA(Sec) binds to EEFSEC:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800797", "l": "The PIDDosome activates CASP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174171", "l": "Association of Cyclin A with the APC/C (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40612", "l": "H2O + trihexanoylglycerol => 2,3-dihexanoyl-sn-glycerol + H(+) + hexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381087", "l": "Dimerization of PERK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071111", "l": "cyclic-guanylate-specific phosphodiesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24118", "l": "(S)-linalool + diphosphate => (2E)-geranyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805640", "l": "AKT phosphorylates KAT6A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65298", "l": "ethylacryloyl-CoA + reduced [electron-transfer flavoprotein] => (2R)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36051", "l": "beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O = 2 beta-L-arabinofuranose"}, {"i": "EC:3.2.1.185", "l": "\"Non-reducing end beta-L-arabinofuranosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6795473", "l": "PDPK1 phosphorylates SGK1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52213", "l": "acetochlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => ethyl formate + H2O + N-(2-ethyl-6-methylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58316", "l": "beta-D-glucosyl-N-hexadecanoylsphing-4E-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47703", "l": "H(+) + ketocytochalasin + NADPH + O2 <=> H2O + iso-precytochalasin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38156", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (6E,10E)-geranyllinalool + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29174", "l": "a ubiquinol + 2 O2 <=> a ubiquinone + 2 H(+) + 2 superoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044824", "l": "retroviral 3' processing activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944262", "l": "Association of procollagen type X (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15648", "l": "16 ATP + 16 H2O + N2 + 4 reduced [flavodoxin] <=> 16 ADP + 18 H(+) + H2 + 2 NH4(+) + 4 oxidized [flavodoxin] + 16 phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008888", "l": "glycerol dehydrogenase [NAD+] activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2176445", "l": "SMURF2 binds SMAD2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39636", "l": "3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11874", "l": "18-hydroxycorticosterone + H2O + 2 oxidized [adrenodoxin] => corticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40058", "l": "1,2,3-trioctanoylglycerol + H2O <=> 2,3-dioctanoyl-sn-glycerol + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390674", "l": "ADRB1 bind ADR,NAd (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44824", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol = a 1,2-diacylglycerol + a monoacyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28366", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosaminouronate = beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}, {"i": "EC:2.4.1.180", "l": "\"Lipopolysaccharide N-acetylmannosaminouronosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49475", "l": "trans-4-hydroxy-L-prolyl-[protein] + UDP-beta-L-arabinofuranose <=> H(+) + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013024", "l": "RHOB binds effectors at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "78.047734625335977", "identifiers": [{"i": "GO:0008982", "l": "protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"}, {"i": "MetaCyc:2.7.1.69-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802937", "l": "Inactive BRAF mutants bind mutant RAS:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58246", "l": "ADP-D-ribose + L-lysyl-[protein] => H2O + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000225", "l": "N-acetylglucosaminylphosphatidylinositol deacetylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183055", "l": "Binding of CBL to EGFR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66240", "l": "ATP + CoA + IC-asc-C9 = AMP + diphosphate + IC-asc-C9-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10602", "l": "prostaglandin D2 => prostaglandin H2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016518", "l": "interleukin-14 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426223", "l": "Cation influx mediated by TRPC3/6/7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31381", "l": "1H-pyrrole + hydrogencarbonate => H2O + pyrrole-2-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57399", "l": "(S)-S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine <=> 3-O-acetylpapaveroxine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47127", "l": "glycine + hexacosanoate <=> H2O + N-hexacosanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20747", "l": "NADP(+) + prostaglandin D2 <=> 15-oxoprostaglandin D2 + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50056", "l": "ATP + glycocholate(in) + H2O = ADP + glycocholate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.4.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14318", "l": "morphine + NAD(+) => H(+) + morphinone + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809521", "l": "BPIF binds bacteria (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047248", "l": "nuatigenin 3-beta-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211924", "l": "CYP4B1 12-hydroxylates ARA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25868", "l": "H2O + N(1),N(12)-diacetylspermine + O2 = 3-acetamidopropanal + H2O2 + N(1)-acetylspermidine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990464", "l": "D-2-hydroxyacid dehydrogenase (quinone) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68595", "l": "ORC2 binds ORC3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13406", "l": "4-coumaroyl-CoA + agmatine => CoA + H(+) + N-(4-guanidinobutyl)-4-hydroxycinnamamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018726", "l": "9-phenanthrol sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22742", "l": "ADP + D-hexose 6-phosphate + H(+) => ATP + D-hexose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170986", "l": "Ral-GDS binds to Ras-GTP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168923", "l": "Collagen type XVIII endostatin release (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674140", "l": "PAQR3 binds inactive RAFs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015437", "l": "lipopolysaccharide floppase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17754", "l": "S-(5-deoxy-D-ribos-5-yl)-L-homocysteine => (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0033283", "l": "ATPase-coupled organic acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12086", "l": "D-fructose + H(+) + NADH => D-mannitol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "79.682896251205548", "identifiers": [{"i": "GO:0019901", "l": "protein kinase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61869", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22005", "l": "ATP + L-seryl-[myosin light chain] => ADP + H(+) + O-phospho-L-seryl-[myosin light chain]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15946", "l": "aldehydo-D-glucose 6-phosphate + L-lysyl-[protein] => H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602549", "l": "Defective TLR3 does not bind viral dsRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61181", "l": "quercetin + UDP-alpha-D-glucose => H(+) + quercetin 3-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419166", "l": "GEFs activate RhoA,B,C (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45058", "l": "H(+) + H2O + nogalonate => deoxynogalonate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44677", "l": "a triacyl-sn-glycerol + all-trans-retinol => a diacylglycerol + an all-trans-retinyl ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44289", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CDP-choline => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15776", "l": "ATP + dihydroxyacetone <=> ADP + dihydroxyacetone phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55591", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-sphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol-1-phosphoceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39561", "l": "(2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30900", "l": "bis(beta-D-glucosyl) crocetin + UDP-alpha-D-glucose => beta-D-gentiobiosyl beta-D-glucosyl crocetin + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29221", "l": "a menaquinol + dihydroxyacetone phosphate => a menaquinone + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3318415", "l": "ATF2 acetylates histone H2B, H4 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.120"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40047", "l": "1,2,3-trioctanoylglycerol + H2O = 1,2-dioctanoyl-sn-glycerol + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798611", "l": "TP53 stimulates and ZNF420 inhibits TP53AIP1 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13591", "l": "ADP + H(+) + phosphate + trans-3-methylglutaconyl-CoA => 3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71849", "l": "LDH tetramer reduces PYR to LACT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1606288", "l": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2464822", "l": "RDH12 reduces atRAL to atROL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2130706", "l": "MHC class II antigen processing (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54282", "l": "(3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate => 2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12327", "l": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine <=> L-asparagine + N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047481", "l": "D-alanine-alanyl-poly(glycerolphosphate) ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39138", "l": "(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + O2 <=> (2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62318", "l": "1-O-salicyl-beta-D-glucose + UDP => salicylate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49143", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63964", "l": "sphinga-4E,14Z-dienine-1-phosphate = (2E,12Z)-hexadecadienal + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23063", "l": "a (2R,3S)-2-alkyl-3-hydroxyalkanoate + ATP <=> a cis-3-alkyl-4-alkyloxetan-2-one + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008832", "l": "dGTPase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58119", "l": "L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose <=> 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706323", "l": "Active FLT3 binds to SLA2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601976", "l": "Defective CYP21A2 does not 21-hydroxylate PROG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20046", "l": "3-oxopropanoate + H2O + NAD(+) => 2 H(+) + malonate + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102496", "l": "GA5 2,3 epoxidase activity"}, {"i": "MetaCyc:RXN-14327"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807585", "l": "BPI binds LPS on the bacterial surface (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35352", "l": "NADP(+) + octadecanoyl-CoA => (2E)-octadecenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51448", "l": "chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] = alpha-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938913", "l": "RUNX1 binds ELF1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102909", "l": "alpha-ketoglutarate reductase activity (NADH-dependent)"}, {"i": "MetaCyc:RXN-8645"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637798", "l": "Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36906", "l": "7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34681", "l": "adenine + alpha-D-ribose 1-methylphosphonate 5-triphosphate => ATP + methylphosphonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39205", "l": "NADP(+) + tetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59701", "l": "D-cellopentaono-1,5-lactone + H2O => D-cellopentaonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216048", "l": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42240", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31945", "l": "(25S)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52834", "l": "7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => 1-hydroxylimonen-2-one + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33990", "l": "(+)-copalyl diphosphate <=> diphosphate + neoabietadiene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62348", "l": "H(+) + NADPH + notoamide E + O2 = H2O + NADP(+) + notoamide C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928640", "l": "PAKs phosphorylate MLC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64460", "l": "acetyl phosphate + L-lysyl-[protein] = H(+) + N(6)-acetyl-L-lysyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49567", "l": "D-sedoheptulose 7-phosphate <=> 2-epi-valiolone + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0008477", "l": "purine nucleosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730858", "l": "Autophosphorylation of BTK/ITK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20296", "l": "3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) <=> 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47180", "l": "(25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+) = (25R)-7alpha,26-dihydroxycholest-4-en-3-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649108", "l": "HTR3A pentamer binds 5HT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909729", "l": "Activation of JAK kinases (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5444511", "l": "Formation of MSH2:MSH3 Complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5213464", "l": "RIPK1 is phosphorylated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938913", "l": "RUNX1 binds ELF1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14562", "l": "(E,E)-piperoyl-CoA + piperidine => CoA + H(+) + N-[(E,E)-piperoyl]piperidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37438", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphate <=> a 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22432", "l": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH"}, {"i": "EC:1.1.1.35", "l": "\"3-hydroxyacyl-CoA dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48350", "l": "a pseudouridine in RNA => a uridine in RNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49767", "l": "ethylenediaminetriacetate + FMNH2 + O2 <=> ethylenediaminediacetate + FMN + glyoxylate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56142", "l": "adenosine + H(+) + L-methionine => H2O + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592297", "l": "Full activation of MMP1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50359", "l": "4-hydroxy-6-methylpretetramide + NADPH + O2 <=> 4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354077", "l": "Integrin alphaIIb beta3 activation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033940", "l": "glucuronoarabinoxylan endo-1,4-beta-xylanase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850534", "l": "PDCL promotes G-protein beta 5 folding (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8847537", "l": "RAB43:GTP binds USP8NL (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66634", "l": "H(+) + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP => L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46309", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] => 17alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17703", "l": "3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + H(+) + phosphate => ATP + geranoyl-CoA + hydrogencarbonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61440", "l": "acetyl-CoA + S-(2-succino)-L-cysteine = CoA + H(+) + N-acetyl-S-(2-succino)-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809707", "l": "MTMR12 binds MTMR2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220971", "l": "CDK8 phosphorylates NICD1 PEST domain mutants  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61628", "l": "5-aminopentanal = 1-piperideine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1605632", "l": "Both hexosaminidase A and B can cleave GalNAc from globoside (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140761", "l": "sequestered tissue factor -> tissue factor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198813", "l": "GSTO dimers reduce DeHA to AscH- (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866277", "l": "AP-2 directly binds some endocytic cargo (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036020", "l": "Defective MPDU1 does not promote transfer of Man to (GlcNAc)2 (Man)8 (PP-Dol)1 by ALG9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050173", "l": "phenylalanine adenylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37893", "l": "15-demethylaclacinomycin T + methanol => aclacinomycin T + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29563", "l": "ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate"}, {"i": "EC:6.3.2.45", "l": "\"UDP-N-acetylmuramate L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694441", "l": "CSNK1D phosphorylates SEC23 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46661", "l": "H(+) + NADPH + progesterone => 5beta-pregnan-3,20-dione + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008995", "l": "ribonuclease E activity"}, {"i": "MetaCyc:3.1.26.12-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66441", "l": "butan-2-one + NADP(+) => but-3-en-2-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61757", "l": "stevioside + UDP-alpha-D-glucose => H(+) + rebaudioside A + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211968", "l": "CYP2W1 oxidises INDOL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322971", "l": "Defective MUT does not isomerise L-MM-CoA to SUCC-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28369", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosaminouronate <=> beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18211", "l": "(2S,4R)-bornyl diphosphate => (2E)-geranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1299359", "l": "Activation of TALK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638006", "l": "ARL3 hydrolyzes GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37390", "l": "(9Z)-octadecenoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228941", "l": "Transcytosis and dissociation of botE:NTNHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14470", "l": "2-aminomuconate 6-semialdehyde + H2O + NAD(+) => (2Z,4E)-2-aminomuconate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37693", "l": "1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47002", "l": "NAD(+) + 2 NADPH + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + NADH + 2 NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5631941", "l": "SESN1,2,3 bind AMPK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33274", "l": "a triacyl-sn-glycerol + H2O <=> a 1,2-diacyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30963", "l": "7,9,9'-tri-cis-neurosporene + a quinone = 7,7',9,9'-tetra-cis-lycopene + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38353", "l": "3-phenylpyruvate + H(+) + NADH => (R)-3-phenyllactate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75856", "l": "Abortive Initiation Before Second Transition (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45759", "l": "(6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2 <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15726", "l": "1,5-anhydro-D-fructose => ascopyrone M + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047966", "l": "glycosulfatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28320", "l": "scutellarin + UDP => scutellarein + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69127", "l": "Formation of the Flap Intermediate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709842", "l": "MAVS binds TOMM70 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35383", "l": "precorrin-6B + S-adenosyl-L-methionine = CO2 + H(+) + precorrin-7 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19499", "l": "beta-alanine + CO2 => H(+) + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66618", "l": "Mg(2+)(out) + 2 Na(+)(in) => Mg(2+)(in) + 2 Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46223", "l": "androst-5-en-3beta,17beta-diol + NAD(+) <=> 3beta-hydroxyandrost-5-en-17-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-622415", "l": "RIP2 binds NEMO (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61748", "l": "rubusoside + UDP-alpha-D-glucose = H(+) + stevioside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10520", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose = 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP"}, {"i": "EC:2.4.1.241", "l": "\"Digalactosyldiacylglycerol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29417", "l": "(S)-lactate(out) + H(+)(out) => (S)-lactate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65971", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ATP + H2O <=> 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5082391", "l": "Trimerization of HSF1 in the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5632652", "l": "Hh-Npp binds CDON and PTCH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005500", "l": "juvenile hormone binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177930", "l": "GAB1 phosphorylation by EGFR kinase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174456", "l": "Joining of adjacent Okazaki fragments of the C-strand (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005143", "l": "interleukin-12 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38526", "l": "1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51611", "l": "(R)-2-hydroxyglutarate + pyruvate <=> (R)-lactate + 2-oxoglutarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33815", "l": "CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate = 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)"}, {"i": "EC:2.7.8.44", "l": "\"Teichoic acid glycerol-phosphate primase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665982", "l": "RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102234", "l": "but-1-en-3-one reductase activity"}, {"i": "MetaCyc:RXN-12293"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851979", "l": "BTNL9 binds immune cell surfaces (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353318", "l": "Insertion of correct bases opposite to the lesion by Pol kappa (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47011", "l": "[DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide <=> [DsrC protein]-dithiol + 2 AH2 + H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40311", "l": "hexanoyl-CoA + O2 = (2E)-hexenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38035", "l": "(2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate = (4Z)-2-oxohept-4-enedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44938", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphate => (9Z,12Z,15Z)-octadecatrienoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901238", "l": "ABC-type tungstate transporter activity"}, {"i": "RHEA:35027", "l": "ATP + H2O + tungstate(in) = ADP + H(+) + phosphate + tungstate(out)"}, {"i": "EC:7.3.2.6", "l": "\"ABC-type tungstate transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951500", "l": "Dissociation of CANX from nonameric complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917839", "l": "apo-Transferrin dissociates from the receptor complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17731", "l": "a cholesterol ester + CoA => an acyl-CoA + cholesterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38987", "l": "nonanoyl-CoA + O2 = (2E)-nonenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30940", "l": "ATP + dIDP => ADP + dITP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12775", "l": "CO2 + dihydroclavaminate + H2O + succinate => 2-oxoglutarate + O2 + proclavaminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28042", "l": "CoA + NAD(+) + pyruvate = acetyl-CoA + CO2 + NADH"}, {"i": "EC:1.2.1.104", "l": "\"Pyruvate dehydrogenase system\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41960", "l": "ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose = ganglioside GA1 (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641229", "l": "TLE oligomerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426209", "l": "DAG activation of TRPC channels (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35084", "l": "diacetylchitobiose-6'-phosphate + H2O => acetate + N'-monoacetylchitobiose-6'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5620975", "l": "MLKL binds PIPs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59845", "l": "(+)-dehydrodiconiferyl alcohol + H(+) + NADPH => (R)-isodihydrodehydrodiconiferyl alcohol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52606", "l": "3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-seryl-[protein] + ADP + H(+) => 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-seryl-[protein] + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19140", "l": "17beta-estradiol + AH2 + O2 <=> 6beta-hydroxyestradiol-17beta + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814094", "l": "ARL1:GTP binds ARFIP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-181450", "l": "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52790", "l": "Mg(2+) + pheophytin a => chlorophyll a + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854209", "l": "TBC1D10A binds JFC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004333", "l": "fumarate hydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55137", "l": "ATP + D-alanine + H(+) => D-alanyl-5'-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33529", "l": "CoA + ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate => acetyl-CoA + ergosta-5,7,22,24(28)-tetraen-3beta-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3134914", "l": "Beta-catenin migrates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16943", "l": "H2O + N-acetylisatin => N-acetylindoxyl + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373087", "l": "Receptor CCR6 binds CCL20 ligand (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373342", "l": "CX3CR1 binds CX3CL1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42218", "l": "1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003859", "l": "3-hydroxybutyryl-CoA dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48204", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentadecanoyl-CoA = (2E)-pentadecenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52542", "l": "alpha-D-ribose 1-phosphate + cytosine => cytidine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21938", "l": "H(+) + N-carbamoylputrescine + phosphate => carbamoyl phosphate + putrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050069", "l": "lysine dehydrogenase activity"}, {"i": "MetaCyc:LYSINE-DEHYDROGENASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22554", "l": "adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+) => 3'-phosphoadenylyl sulfate + an alcohol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53444", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 11beta,17beta-dihydroxyandrost-4-ene-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11063", "l": "ATP + L-isoleucine + tRNA(Ile) <=> AMP + diphosphate + L-isoleucyl-tRNA(Ile)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322431", "l": "XIAP binds TLE (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944216", "l": "Association of procollagen type XV (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296233", "l": "T2Rs bind bitter-tasting compounds (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798489", "l": "S100A7 or S100A7A binds Zn2+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16193", "l": "an (R)-2-haloacid + H2O = a (2R)-2-hydroxycarboxylate + a halide anion + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17200", "l": "2 3-(4-hydroxyphenyl)pyruvate + O2 <=> 2 4-hydroxyphenylacetate + 2 CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14717", "l": "D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate"}, {"i": "EC:2.5.1.54", "l": "\"3-deoxy-7-phosphoheptulonate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694576", "l": "nsp3 binds to nsp7-8 and nsp12-16 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62238", "l": "a cytidine dimer in DNA + H(+) => a cytidine(6-4)cytidine in DNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49462", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH4(+) => (2Z,4E)-2-aminomuconate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24922", "l": "L-homoserine <=> 2-aminobut-2-enoate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031807", "l": "H1 histamine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38858", "l": "2 [Fe(II)-cytochrome b5] + a 1,2-saturated fatty acid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (R)-2-hydroxy fatty acid + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57569", "l": "7-deoxyloganetic alcohol + O2 + reduced [NADPH--hemoprotein reductase] => 7-deoxyloganetic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1640164", "l": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12925", "l": "D-erythrose 4-phosphate + L-lysyl-[protein] = H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52712", "l": "dTMP + H2O = 2-deoxy-D-ribose 5-phosphate + thymine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25866", "l": "4-acetamidobutanal + H2O2 + propane-1,3-diamine => H2O + N(1)-acetylspermidine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109701", "l": "PDPK1 binds PIP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791088", "l": "Expression of GFPT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14263", "l": "6-O-[(E)-sinapoyl]-D-glucono-1,5-lactone + CoA => (E)-sinapoyl-CoA + D-glucono-1,5-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14758", "l": "2 [Fe(III)cytochrome c] + L-galactono-1,4-lactone => 2 [Fe(II)cytochrome c] + 3 H(+) + L-ascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22736", "l": "5-formimidoyltetrahydrofolate + 2 H(+) = 5,10-methenyltetrahydrofolate + NH4(+)"}, {"i": "EC:4.3.1.4", "l": "\"Formimidoyltetrahydrofolate cyclodeaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30790", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 <=> (6R)-L-erythro-6,7-dihydrobiopterin + H2O + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102105", "l": "demethoxycurcumin synthase activity from feruloylacetyl-CoA"}, {"i": "RHEA:35119", "l": "(4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O = bisdemethoxycurcumin + CO2 + 2 CoA"}, {"i": "RHEA:35139", "l": "(E)-4-coumaroyl-CoA + (E)-feruloylacetyl-CoA + H2O = CO2 + 2 CoA + demethoxycurcumin"}, {"i": "EC:2.3.1.219", "l": "\"Demethoxycurcumin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008043", "l": "MAPK8 phosphorylation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023617", "l": "Butyrylcholinesterase hydrolyzes acyl Ghrelin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11367", "l": "ATP + H2O + pyruvate <=> AMP + 2 H(+) + phosphate + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35052", "l": "N,N'-diacetylchitobiose(out) => N,N'-diacetylchitobiose(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202291", "l": "Activation of Lck (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44168", "l": "dodecanoate + 2 H(+) + NADH = dodecanal + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613219", "l": "RRAD gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23708", "l": "[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)"}, {"i": "EC:2.4.1.129", "l": "\"Peptidoglycan glycosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11790", "l": "H(+) + NADH + NH4(+) + oxaloacetate => H2O + L-aspartate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12655", "l": "CO2 + NADH + pyruvate => (S)-malate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209921", "l": "Monoiodinated tyrosine can be deiodinated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.91"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852362", "l": "GTSE1 binds CDKN1A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019960", "l": "C-X3-C chemokine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58219", "l": "A + dihydroserpentine <=> AH2 + serpentine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944229", "l": "Association of procollagen type IX (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34452", "l": "dTDP-6-deoxy-beta-L-talose => dTDP-beta-L-rhamnose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48132", "l": "(2E,6E)-farnesyl phosphate + H2O = (2E,6E)-farnesol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19208", "l": "dCTP + 2 H2O <=> diphosphate + dUMP + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373705", "l": "Caspase cleavage of DCC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031889", "l": "urotensin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38237", "l": "1-O-octadecyl (9Z)-octadecenoate + CoA => (9Z)-octadecenoyl-CoA + octadecan-1-ol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0039631", "l": "DNA translocase activity involved in viral DNA genome packaging"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000247", "l": "Endosomal CBLIF:Cbl translocates to lysosome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-398185", "l": "LARG binds plexin B1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66581", "l": "3'-phosphoadenylyl sulfate + bisphenol A => adenosine 3',5'-bisphosphate + bisphenyl A sulfate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029680", "l": "Caspase-7 translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29469", "l": "H(+)(in) + K(+)(out) => H(+)(out) + K(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12298", "l": "dopamine + secologanin => deacetylipecoside + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120136", "l": "dUMP kinase activity"}, {"i": "RHEA:30655", "l": "ATP + dUMP = ADP + dUDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48887", "l": "NADP(+) + protochlorophyllide a <=> 3,8-divinyl protochlorophyllide a + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388468", "l": "AVP(20-28) binds AVPR1A,B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37255", "l": "A + D-asparagine + H2O = 2-oxosuccinamate + AH2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035800", "l": "deubiquitinase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56398", "l": "(3R)-hydroxybutanoate trimer + [(3R)-hydroxybutanoate](n-3) + H(+) => [(3R)-hydroxybutanoate](n) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380586", "l": "loading of Serotonin in synaptic vesicles (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12081", "l": "acetyl-CoA + H(+) + malonyl-[ACP] => 3-oxobutanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1606564", "l": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672011", "l": "p-AMPK:AMP binds the ULK complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247837", "l": "WNT ligands traffic to the Golgi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050068", "l": "lysine carbamoyltransferase activity"}, {"i": "RHEA:17121", "l": "carbamoyl phosphate + L-lysine = H(+) + L-homocitrulline + phosphate"}, {"i": "EC:2.1.3.8", "l": "\"Lysine carbamoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-196026", "l": "Dab2 is recruited to the junctional plaques (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14215", "l": "ADP + beta-D-fructose 1,6-bisphosphate + H(+) => ATP + beta-D-fructose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35497", "l": "4-aminobenzoate + L-glutamate => H2O + N-(4-aminobenzoyl)-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080014", "l": "thalianol hydroxylase activity"}, {"i": "MetaCyc:RXN-9631"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202127", "l": "eNOS synthesizes NO (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022855", "l": "protein-N(PI)-phosphohistidine-glucose phosphotransferase system transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47701", "l": "H(+) + ketocytochalasin + NADPH + O2 => H2O + iso-precytochalasin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38796", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2537499", "l": "Gelatin degradation by MMP19 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033932", "l": "1,3-alpha-L-fucosidase activity"}, {"i": "MetaCyc:3.2.1.111-RXN"}, {"i": "EC:3.2.1.111", "l": "\"1,3-alpha-L-fucosidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052760", "l": "coenzyme F420-dependent 2,4-dinitrophenol reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-179417", "l": "Multiubiquitination of Nek2A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50854", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660757", "l": "Ub-SNCA dissociates from the conjugating enzyme (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156910", "l": "Formation of eEF1B complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156930", "l": "GTP-binding activates eEF2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47058", "l": "4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O => 4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791157", "l": "Expression of DNAJC3 (p58IPK) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8870461", "l": "RABGGTA and RABGGTB bind (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60620", "l": "N-hexanoyl-sphing-4-enine-1-phosphocholine = choline + N-(hexanoyl)-sphing-4-enine-1,3-cyclic phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373717", "l": "DCC interacts with DIP13alpha (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49383", "l": "5-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 5,20-dihydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34838", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-4-hydroxy-15-methylhexadecasphinganine <=> a 1,2-diacyl-sn-glycerol + N-acyl-4-hydroxy-15-methylhexadecasphinganine-1-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811412", "l": "Active ARF recruits coatomer to the Golgi (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42898", "l": "H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine => L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28580", "l": "Co(2+)(out) => Co(2+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11464", "l": "2 glutathione + L,L-homocystine = glutathione disulfide + 2 L-homocysteine"}, {"i": "EC:1.8.4.1", "l": "\"Glutathione--homocystine transhydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57048", "l": "AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = 2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804379", "l": "PRMT5 binds TTC5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48796", "l": "O2 + prostaglandin H1 + reduced [NADPH--hemoprotein reductase] = 19-hydroxyprostaglandin H1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102693", "l": "UDP-glucose:kinetin 7-N-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-4731"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48609", "l": "A + a 2,3-saturated acyl-CoA => a 2,3-dehydroacyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008714", "l": "AMP nucleosidase activity"}, {"i": "KEGG.REACTION:R00182"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59049", "l": "D-ornithine + H(+) => CO2 + putrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26088", "l": "(4S)-limonene + H(+) + NADPH + O2 <=> H2O + limonene 1,2-epoxide + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38801", "l": "1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450551", "l": "AUF1 binds translation and heat shock proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13612", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.21"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14460", "l": "glyoxylate + H2O + pentanoyl-CoA <=> 3-propylmalate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110311", "l": "POLZ extends translesion synthesis (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35789", "l": "H(+) + kanamycin C + UDP => paromamine + UDP-alpha-D-kanosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20767", "l": "(S)-methylmalonyl-CoA + pyruvate <=> oxaloacetate + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433542", "l": "Phosphorylation and activation of VAV1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0030547", "l": "signaling receptor inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33979", "l": "DIBOA beta-D-glucoside + H2O = D-glucose + DIBOA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51792", "l": "H(+) + NADH + O2 + salicylate = 2,3-dihydroxybenzoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63876", "l": "2-oxoglutarate + 3(1)-hydroxy-L-isoleucine + O2 = (4S)-3(1),4-dihydroxy-L-isoleucine + CO2 + succinate"}, {"i": "EC:1.14.11.75", "l": "\"3(1)-hydroxy-L-isoleucine 4-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16244", "l": "an NDP-alpha-D-glucose + D-fructose <=> a ribonucleoside 5'-diphosphate + H(+) + sucrose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34951", "l": "3-hydroxypropanoate(out) = 3-hydroxypropanoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13330", "l": "A + a 3-oxosteroid => a 3-oxo-Delta(1)-steroid + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19739", "l": "4-aminobutanoate + L-glutamate => 4-(gamma-L-glutamylamino)butanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60357", "l": "H2O + N-octanoylanthranilate => anthranilate + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58053", "l": "(2-aminoethyl)phosphonate + acetyl-CoA => (2-acetamidoethyl)phosphonate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018653", "l": "3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1297444", "l": "Binding of cAMP to HCN channels (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "74.836269892493803", "identifiers": [{"i": "GO:0016801", "l": "hydrolase activity, acting on ether bonds"}, {"i": "EC:3.3.-.-", "l": "\"Acting on ether bonds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25560", "l": "9alpha-copalyl diphosphate = 9beta-pimara-7,15-diene + diphosphate"}, {"i": "EC:4.2.3.35", "l": "\"Syn-pimara-7,15-diene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203553", "l": "eNOS binds NOSIP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951727", "l": "cAMP binds PKA tetramer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13696", "l": "(6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018786", "l": "haloalkane dehalogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44109", "l": "H2O + heptanal + NAD(+) => 2 H(+) + heptanoate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58557", "l": "15alpha-stemmadenine intermediate II + H2O => (16S)-deshydroxymethyl-stemmadenine + formate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29324", "l": "fumarate(in) + succinate(out) => fumarate(out) + succinate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080017", "l": "alpha-humulene synthase activity"}, {"i": "RHEA:31895", "l": "(2E,6E)-farnesyl diphosphate = (1E,4E,8E)-alpha-humulene + diphosphate"}, {"i": "EC:4.2.3.104", "l": "\"Alpha-humulene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379993", "l": "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41954", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate => 2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671747", "l": "Phosphorylated LEPR Binds SHP2 (PTPN11) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022882", "l": "protein-N(PI)-phosphohistidine-beta-glucoside phosphotransferase system transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798374", "l": "DYRK2 phosphorylates TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55439", "l": "ferruginol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + salviol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391934", "l": "DP2 receptor can bind PGD2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198295", "l": "TRKA phosphorylates IRS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22030", "l": "CoA + taxa-4(20),11-dien-5alpha-yl acetate => acetyl-CoA + taxa-4(20),11-dien-5alpha-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60059", "l": "a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H(+) + NADH + O2 <=> a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + 2 H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.10.-.-", "l": "\"Transferring molybdenum- or tungsten-containing groups\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.23.-.-", "l": "\"Reducing C-O-C group as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53967", "l": "4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + ribostamycin <=> gamma-L-glutamyl-butirosin B + H(+) + holo-[BtrI ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416358", "l": "G alpha (q) inhibits PI3K alpha (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3262512", "l": "G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20150", "l": "O2 + quinine + reduced [NADPH--hemoprotein reductase] => 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047789", "l": "creatininase activity"}, {"i": "RHEA:14533", "l": "creatinine + H2O = creatine"}, {"i": "EC:3.5.2.10", "l": "\"Creatininase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48385", "l": "2,3-saturated fatty acid + H2O2 => 3-hydroxy fatty acid + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009973", "l": "adenylyl-sulfate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51810", "l": "(9Z)-octadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (9Z)-octadecenoate(out) + ATP(in) + CoA(in) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10662", "l": "D-seryl-[protein] => L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63194", "l": "glycine betaine + 2 H(+) + phosphate => [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41473", "l": "ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oryzalexin D + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015327", "l": "cystine:glutamate antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29786", "l": "ATP + H2O + L-cysteine(in) <=> ADP + H(+) + L-cysteine(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209183", "l": "Scaffolding protein CKA binds BSK and phosphorylated HEP kinases (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61325", "l": "(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxycostunolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250264", "l": "TXNIP binds reduced thioredoxin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.33"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61978", "l": "5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin] => glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903878", "l": "11-deoxycorticosterone binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18061", "l": "5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran = methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin"}, {"i": "EC:2.3.1.101", "l": "\"Formylmethanofuran--tetrahydromethanopterin N-formyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43528", "l": "L-serine + NAD(+) = 2-aminomalonate semialdehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42057", "l": "13-cis-retinol + NAD(+) => 13-cis-retinal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56928", "l": "abieta-7,13-dien-18-al + O2 + reduced [NADPH--hemoprotein reductase] = abieta-7,13-dien-18-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047562", "l": "3-hydroxyaspartate aldolase activity"}, {"i": "RHEA:14377", "l": "(3R)-3-hydroxy-L-aspartate = glycine + glyoxylate"}, {"i": "EC:4.1.3.14", "l": "\"L-erythro-3-hydroxyaspartate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62211", "l": "3-methylphenol + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-hydroxybenzyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63198", "l": "(10bR,4aS)-oxomaritidine + NADP(+) => (10bR,4aS)-noroxomaritidine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50947", "l": "3-phenylpropanoate + NAD(+) <=> (E)-cinnamate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3321805", "l": "NSL acetylates histone H4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44514", "l": "1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16636", "l": "guanosine(34) in tRNA + queuine <=> guanine + queuosine(34) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20980", "l": "2 bilirubin IXalpha + O2 = 2 biliverdin IXalpha + 2 H2O"}, {"i": "EC:1.3.3.5", "l": "\"Bilirubin oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734713", "l": "ORC6 translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38825", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15667", "l": "H2O + N(6)-(D-fructosyl)-L-lysyl-[protein] => aldehydo-D-glucose + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51463", "l": "H2O + N-(9Z-octadecenoyl)-L-glutamate <=> (9Z)-octadecenoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0022842", "l": "narrow pore channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655833", "l": "Expression of TM7SF2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40750", "l": "2-oxoglutarate + L-lysine + O2 <=> (3S)-3-hydroxy-L-lysine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14147", "l": "ADP + H(+) + phosphoguanidinoacetate => ATP + guanidinoacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656947", "l": "OGG1beta translocates to mitochondria (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-901047", "l": "Binding of ERp57 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5336184", "l": "GPR37L binds prosaposin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23100", "l": "ATP + dAMP = ADP + dADP"}, {"i": "EC:2.7.4.11", "l": "\"(Deoxy)adenylate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5099899", "l": "WNT5A binds FZD4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31692", "l": "(9Z,12Z)-octadecadienoate + O2 => (9R)-hydroperoxy-(10E,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211948", "l": "CYP3A4 can N-demethylate loperamide (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46752", "l": "7alpha-hydroxycholest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943279", "l": "GGT dimers hydrolyse GSH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102650", "l": "cyclo-acetoacetyl-L-tryptophan synthetase activity"}, {"i": "MetaCyc:RXN-15811"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10498", "l": "H(+) + N(omega)-methyl-L-arginyl-[myelin basic protein] + S-adenosyl-L-homocysteine => L-arginyl-[myelin basic protein] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27489", "l": "2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate"}, {"i": "EC:5.3.1.28", "l": "\"D-sedoheptulose 7-phosphate isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849435", "l": "PTPN1 dephosphorylates PTK6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22513", "l": "3 H(+) + precorrin-8X => hydrogenobyrinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.50", "l": "\"Pentachlorophenol monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75862", "l": "Fall Back to Closed Pre-initiation Complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17047", "l": "1-(3,4-dimethoxyphenyl)ethane-1,2-diol + 3,4-dimethoxybenzaldehyde + H2O => 1,2-bis-(3,4-dimethoxyphenyl)propane-1,3-diol + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48030", "l": "acetate + diacetylglycerol + H(+) => H2O + triacetin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218814", "l": "PAK2 autophorylates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41270", "l": "H2O + N-(15Z-tetracosenoyl)-sphing-4-enine <=> (15Z)-tetracosenoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8934446", "l": "Activated PKC phosphorylates SHC1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50549", "l": "prostaglandin E1 => H2O + prostaglandin A1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63409", "l": "6-chloropyridine-2,3,5-triol + FADH2 + O2 => 3,6-dihydroxypyridine-2,5-dione + chloride + FAD + 3 H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52014", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45391", "l": "H2O + N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-octadecanoyl-sn-glycero-3-phospho-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32013", "l": "(+)-T-muurolol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25768", "l": "3-carboxy-2-oxobutanoate + H(+) => 2-oxobutanoate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43231", "l": "L-glutamine(104)-[histone H2A] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutamine(104)-[histone H2A] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48960", "l": "[thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.6", "l": "\"Leucolysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814678", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46932", "l": "2-epi-5-epi-valiolone 7-phosphate = 5-epi-valiolone 7-phosphate"}, {"i": "EC:5.1.3.35", "l": "\"2-epi-5-epi-valiolone 7-phosphate 2-epimerase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045499", "l": "chemorepellent activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932327", "l": "NFE2L2 binds KEAP1:CUL3:RBX1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19122", "l": "an S-substituted glutathione(in) + ATP + H2O => ADP + an S-substituted glutathione(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4167511", "l": "HLCS biotinylates ACACB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192051", "l": "CYP7A1 7-hydroxylates CHOL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14069", "l": "D-fructose + NADP(+) = 5-dehydro-D-fructose + H(+) + NADPH"}, {"i": "EC:1.1.1.124", "l": "\"Fructose 5-dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64979", "l": "8-oxo-dGTP + 2 H2O <=> 8-oxo-dGMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031747", "l": "type 2 cysteinyl leukotriene receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26475", "l": "beta-D-galactosyl-(1->4)-L-rhamnose + phosphate => alpha-D-galactose 1-phosphate + L-rhamnopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45325", "l": "H2O + N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine => H(+) + N-tetracosanoyl-sphing-4-enine + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22364", "l": "L-quinate + NAD(+) = 3-dehydroquinate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16058", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73945", "l": "FAS-mediated dimerization of procaspase-8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15366", "l": "3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + UDP-alpha-D-xylose => 3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612514", "l": "p-S133 CREB and p-S103 SRF bind the EGR1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65949", "l": "a 2'-deoxyadenosine in DNA + acetyl-CoA + AH2 + NH4(+) + O2 => A + a N(6)-methylcarbamoyl-2'-deoxyadenosine in DNA + CoA + H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102711", "l": "gibberellin A25,oxoglutarate:oxygen oxidoreductase activity"}, {"i": "MetaCyc:RXN-6541"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874080", "l": "SRC phosphorylates PTK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38726", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17123", "l": "H(+) + L-homocitrulline + phosphate => carbamoyl phosphate + L-lysine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018136", "l": "peptidyl-thiazoline dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090736", "l": "MATH domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30804", "l": "4-aminobutanal + H2O + NADP(+) => 4-aminobutanoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010176", "l": "homogentisate phytyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210277", "l": "Interaction of PECAM-1 and SHP-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51978", "l": "an L-N,N-dihydroxypolyhomomethionine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an L-N-hydroxypolyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17210", "l": "1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O => 2-formylglutarate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40166", "l": "D-glyceraldehyde + H2O + NADP(+) <=> (R)-glycerate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13448", "l": "(R)-pantetheine + H2O <=> (R)-pantothenate + cysteamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69685", "l": "CHEK2 phosphorylates TP53 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11179", "l": "2-alpha-D-glucosyl-D-glucose + phosphate <=> beta-D-glucose 1-phosphate + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30116", "l": "decanoyl-[ACP] + H2O => decanoate + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007860", "l": "RUNX2 binds TWIST1,(TWIST2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004806", "l": "triglyceride lipase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015243", "l": "cycloheximide transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24892", "l": "4-hydroxy-L-glutamate + H(+) + NADH => 1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42989", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => cembrene C + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34150", "l": "2-deoxy-L-scyllo-inosose + L-glutamine <=> 2-deoxy-scyllo-inosamine + 2-oxoglutaramate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5250217", "l": "ARL2:GTP binds ARL2BP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52478", "l": "estrone 3-O-(beta-D-glucuronate) + H(+) + UDP => estrone + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190141", "l": "ALAD binds to Pb2+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034544", "l": "trans-ACOHDA hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015309", "l": "cycloheximide:proton antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3364026", "l": "SET1 complex trimethylates H3K4 at the MYC gene (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0150025", "l": "oxidised low-density lipoprotein particle receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67000", "l": "2-methylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 3 CO2 + 4 CoA + phlorisobutanophenone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16695", "l": "(Z)-2-methyl-5-isopropylhexa-2,5-dienal => alpha-pinene oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28652", "l": "inosine + O2 => 9-riburonosylhypoxanthine + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37590", "l": "2-oxoglutarate + D-lysine <=> 6-amino-2-oxohexanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192704", "l": "Synthesis of PB1-F2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332359", "l": "Active calmodulin binds CAMK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48685", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O => [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39357", "l": "(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+) => (2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52024", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 = 18S-resolvin E2 + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-606287", "l": "RSF complex binds the centromere (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198508", "l": "malate + NAD+ <=> oxaloacetate + NADH + H+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21098", "l": "3-dehydroshikimate + H2O => 3-dehydroquinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13012", "l": "H2O + N-formyl-L-kynurenine <=> formate + H(+) + L-kynurenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31804", "l": "H2O + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose => 2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66529", "l": "ATP + O-(5'-adenylyl)-L-tyrosyl-[protein] => diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62717", "l": "stemphyloxin I => stemphyloxin II"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16615", "l": "an N-acetylarylamine + CoA => acetyl-CoA + an arylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30586", "l": "2-demethylmenaquinol-8 + H(+) + trimethylamine N-oxide <=> 2-demethylmenaquinone-8 + H2O + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617096", "l": "Defective POMGNT1 does not transfer GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857308", "l": "Activated CEBPB and NFKB complex bind IL8 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61197", "l": "(E)-feruloyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] => CoA + H(+) + myricetin 3-O-[(6-O-[(E)-feruloyl]-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64667", "l": "a long-chain fatty acyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018579", "l": "protocatechuate 4,5-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43028", "l": "L-cysteate = 2-aminoprop-2-enoate + H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17974", "l": "diphosphate + IMP => 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067640", "l": "IL6 binds IL6R-2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47101", "l": "choloyl-CoA + taurine => CoA + H(+) + taurocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54272", "l": "2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2 = (3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705137", "l": "TBK1 or IKBKE forms homodimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848339", "l": "PNPLA5 hydrolyzes TAG (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15405", "l": "(3R)-3-hydroxybutanoyl-CoA + [(3R)-hydroxybutanoate](n) = [(3R)-hydroxybutanoate](n+1) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44562", "l": "4-hydroxy-3-all-trans-heptaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-heptaprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63515", "l": "biphenyl-2,2'-diol + H(+) + NADH + O2 <=> biphenyl-2,2',3-triol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008727", "l": "GDP-mannose mannosyl hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218836", "l": "PTK2beta binds alphaVbeta3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42820", "l": "2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2 = H2O + 2 NADP(+) + tetracenomycin C"}, {"i": "RHEA:42824", "l": "2 H(+) + 2 NADH + 2 O2 + tetracenomycin A2 = H2O + 2 NAD(+) + tetracenomycin C"}, {"i": "EC:1.14.13.200", "l": "\"Tetracenomycin A2 monooxygenase-diooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3296304", "l": "GPR31 is a receptor for 12(S)-HETE (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912724", "l": "CBL binds B-cell linker protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050177", "l": "phenylpyruvate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41251", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35336", "l": "H(+) + isopentadecanoyl-CoA + malonyl-CoA => 3-oxoisoheptadecanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928656", "l": "gamma-secretase cleaves EPHB2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0004935", "l": "adrenergic receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3318415", "l": "ATF2 acetylates histone H2B, H4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000269", "l": "toxin export channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399952", "l": "Phosphorylation of LIMK-1 by PAK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61623", "l": "[(1->2)-beta-D-mannosyl](n) + GDP-alpha-D-mannose <=> [(1->2)-beta-D-mannosyl](n+1) + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35392", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA => (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57870", "l": "(E)-2,4-dihydroxycinnamoyl-CoA + CO2 + succinate => (E)-4-coumaroyl-CoA + 2-oxoglutarate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16283", "l": "ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + H(+) => ATP + dihydrostreptomycin 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27288", "l": "diacetyl + H(+) + NADH => (S)-acetoin + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623643", "l": "RDH13 reduces atRAL to atROL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848606", "l": "PTK6 phosphorylates PXN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16165", "l": "L-tryptophan + O2 = CO2 + H2O + indole-3-acetamide"}, {"i": "EC:1.13.12.3", "l": "\"Tryptophan 2-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018566", "l": "1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015128", "l": "gluconate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482892", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1977959", "l": "ERBB4 forms heterodimers with EGFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010736", "l": "serum response element binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10140", "l": "NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin D2"}, {"i": "EC:1.1.1.188", "l": "\"Prostaglandin-F synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029690", "l": "Caspase-6 translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40726", "l": "(9E)-octadecenoyl-CoA + H2O <=> (9E)-octadecenoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-482772", "l": "Release of platelet cytosolic components (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16008", "l": "galactarate <=> 5-dehydro-4-deoxy-D-glucarate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.17"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430180", "l": "NCK recruits WASP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51478", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O => a ribonucleoside 5'-triphosphate + formate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132247", "l": "CD59 binds C5b:C6:C7:C8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58019", "l": "8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55513", "l": "cucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] => 11-hydroxycucurbitadienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453183", "l": "p-Y348-SYK dissociates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43518", "l": "2-carboxy-5-(dihydroxymethyl)furan => 2-carboxy-5-formylfuran + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28478", "l": "galactarate(in) = galactarate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16433", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25621", "l": "geranylgeranyl diphosphate = tuberculosinyl diphosphate"}, {"i": "EC:5.5.1.16", "l": "\"Halimadienyl-diphosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27835", "l": "a menaquinone + succinate => a menaquinol + fumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42673", "l": "hercynine + L-gamma-glutamyl-L-cysteine + O2 => H2O + L-gamma-glutamyl-hercynylcysteine S-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48608", "l": "A + a 2,3-saturated acyl-CoA = a 2,3-dehydroacyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050472", "l": "zeatin reductase activity"}, {"i": "RHEA:12757", "l": "dihydrozeatin + NADP(+) = H(+) + NADPH + zeatin"}, {"i": "EC:1.3.1.69", "l": "\"Zeatin reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63623", "l": "ATP + dodecanoate + holo-[ACP] <=> AMP + diphosphate + dodecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870469", "l": "RGGT geranylgeranylates RAB proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12288", "l": "an alpha-L-fucoside + H2O = an alcohol + L-fucose"}, {"i": "EC:3.2.1.51", "l": "\"Alpha-L-fucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70577", "l": "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009309", "l": "RUNX2 binds STUB1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15066", "l": "H2O + N(4)-benzoylagmatine => agmatine + benzoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44894", "l": "an N-(2-hydroxyacyl)-beta-D-galactosyl-sphinganine + H(+) + UDP => an N-(2-hydroxyacyl)-sphinganine + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38179", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 19-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21878", "l": "(S)-usnate + 2 H(+) + NADH => (6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050294", "l": "steroid sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944242", "l": "Association of procollagen type XXVII (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10122", "l": "inosine in double-stranded RNA + NH4(+) => adenosine in double-stranded RNA + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803063", "l": "RNASEs bind bacterial LPS, PGN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41654", "l": "2-deoxy-alpha-L-fucosylaclacinomycin S + dTDP + H(+) => aclacinomycin S + dTDP-2-deoxy-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033949", "l": "fructan beta-(2,6)-fructosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60930", "l": "17-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24457", "l": "alpha-ribazole 5'-phosphate + H2O => alpha-ribazole + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034188", "l": "apolipoprotein A-I receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382057", "l": "Release of novel PDGFs as latent factors (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14494", "l": "H2O + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] => ADP-D-ribose + L-arginyl-[dinitrogen reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.115"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044604", "l": "ABC-type phytochelatin transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203977", "l": "SAR1 Activation And Membrane Binding (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50123", "l": "taurine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34961", "l": "(R)-carnitine(out) => (R)-carnitine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030268", "l": "methylenetetrahydromethanopterin dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174690", "l": "TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013159", "l": "CDC42 GEFs activate CDC42 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22431", "l": "N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 <=> 2 H2O + isopenicillin N"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44082", "l": "AMP + diphosphate + undecanoyl-CoA => ATP + CoA + undecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031799", "l": "type 2 metabotropic glutamate receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851888", "l": "MET binds SHC1-2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19770", "l": "phaseollidin hydrate => H2O + phaseollidin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49123", "l": "H(+) + NADPH + O2 + protoviolaceinate <=> H2O + NADP(+) + violaceinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32698", "l": "(2E)-geranyl diphosphate <=> (-)-car-3-ene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36099", "l": "benzoate + S-adenosyl-L-methionine = methyl benzoate + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.273", "l": "\"Benzoate O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444047", "l": "Receptor FFAR3 binds carboxylates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36602", "l": "hydrogen sulfide + NAD(+) <=> NADH + sulfur"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37358", "l": "H2O + uridine 2'-phosphate <=> phosphate + uridine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71495", "l": "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.37"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11972", "l": "4 Fe(2+) + 6 H2O + O2 = 12 H(+) + 4 iron(III) oxide-hydroxide"}, {"i": "EC:1.16.3.2", "l": "\"Bacterial non-heme ferritin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814096", "l": "ARL1:GTP binds SCOC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209924", "l": "Dopa is decarboxylated to dopamine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047407", "l": "ADP-ribosyl-[dinitrogen reductase] hydrolase activity"}, {"i": "MetaCyc:3.2.2.24-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050260", "l": "ribose-5-phosphate-ammonia ligase activity"}, {"i": "KEGG.REACTION:R01053"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47112", "l": "chenodeoxycholate + glycine = glycochenodeoxycholate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12740", "l": "5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine <=> [PrdC protein]-L-selenocysteine/L-cysteine + D-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58400", "l": "heptan-1-ol + NADP(+) = H(+) + heptanal + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25686", "l": "H(+) + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys) = L-cysteinyl-tRNA(Cys) + phosphate"}, {"i": "EC:2.5.1.73", "l": "\"O-phospho-L-seryl-tRNA:Cys-tRNA synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210285", "l": "Trans-homophilic interaction of PECAM-1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430096", "l": "GP1b-IX-V binds filamin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64844", "l": "(2E)-geraniol + benzoyl-CoA = (2E)-geranyl benzoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084505", "l": "Laminins bind HSPG2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50584", "l": "13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36409", "l": "diphosphate + H2O + L-threonylcarbamoyladenylate => ATP + hydrogencarbonate + L-threonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.15"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102703", "l": "camphene synthase activity"}, {"i": "RHEA:25484", "l": "(2E)-geranyl diphosphate = (1S,4R)-camphene + diphosphate"}, {"i": "EC:4.2.3.117", "l": "\"(-)-camphene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665409", "l": "GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49609", "l": "2-glutathionyl-2-methylbut-3-enal + H2O + NAD(+) => 2-glutathionyl-2-methylbut-3-enoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52789", "l": "chlorophyll a + 2 H(+) => Mg(2+) + pheophytin a"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28968", "l": "L-proline(in) + Na(+)(in) => L-proline(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10158", "l": "12-hydroxydihydrochelirubine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dihydrochelirubine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39550", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA <=> (2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952128", "l": "RUNX3 binds TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44090", "l": "AMP + diphosphate + heptanoyl-CoA => ATP + CoA + heptanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429992", "l": "PARN deadenylates mRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202713", "l": "CD84 homodimerises (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71445", "l": "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357472", "l": "PAK1-3 autophosphorylates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.36"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58983", "l": "citral + H2O + O2 <=> 3,7-dimethylocta-2,6-dienoate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39921", "l": "1-O-(alk-1-enyl)-sn-glycerol + phosphate => 1-O-(alk-1-enyl)-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16444", "l": "H2O + L-glutaminyl-[protein] <=> L-glutamyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36118", "l": "gibberellin A3 + S-adenosyl-L-methionine <=> O-methyl gibberellin A3 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9724290", "l": "GNRHR2 binds GNRH1,2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13253", "l": "1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389862", "l": "Conversion of glyoxylate to oxalate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30126", "l": "H2O + tetradecanoyl-[ACP] <=> H(+) + holo-[ACP] + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215406", "l": "PRMT5 binds WDR77 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847534", "l": "RAB43 hydrolyses GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18589", "l": "[glutamine synthetase]-L-tyrosine + ATP = [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate"}, {"i": "EC:2.7.7.42", "l": "\"[Glutamine synthetase] adenylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694661", "l": "TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047827", "l": "D-lysopine dehydrogenase activity"}, {"i": "RHEA:17625", "l": "D-lysopine + H2O + NADP(+) = H(+) + L-lysine + NADPH + pyruvate"}, {"i": "EC:1.5.1.16", "l": "\"D-lysopine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046562", "l": "glucose oxidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103044", "l": "ribosomal protein S6 glutamate-glutamate ligase activity"}, {"i": "MetaCyc:RXN0-6726"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50422", "l": "H(+) + N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu) => L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5250947", "l": "B-WICH complex binds rDNA promoter (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047721", "l": "indoleacetate-lysine synthetase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17507", "l": "a long-chain fatty acid + ethanolamine => H2O + N-(long-chain fatty acyl)ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103096", "l": "CYP79F1 dihomomethionine monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26464", "l": "3-methyl-6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + H(+) + S-adenosyl-L-homocysteine => 6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008506", "l": "sucrose:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54479", "l": "1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + dodecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373729", "l": "Neurofascin binds Ankyrin-G (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9656893", "l": "OPN1MW binds 11cRAL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46711", "l": "2-hydroxybenzoyl-5'-AMP + holo-[non-ribosomal peptide synthase] <=> AMP + H(+) + salicyl-[non-ribosomal peptide synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2559568", "l": "SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10985", "l": "(S)-lactate + oxaloacetate => (S)-malate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404193", "l": "IGF1R phosphorylates SHC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799466", "l": "TP53I3 dimerizes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.45", "l": "\"Atrolysin F\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24181", "l": "2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909552", "l": "Phosphorylation of STAT1 at Ser727 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16944", "l": "N-acetylindoxyl + O2 <=> H2O + N-acetylisatin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702997", "l": "linafinib-resistant FLT3 mutants don't bind linifanib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696267", "l": "RND3 binds GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45274", "l": "12-hydroxy-(9Z)-octadecenoate + phosphate => 12-phosphooxy-(9Z)-octadecenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034026", "l": "L-amino-acid alpha-ligase activity"}, {"i": "RHEA:44332", "l": "ATP + L-alanine + L-anticapsin = ADP + bacilysin + H(+) + phosphate"}, {"i": "EC:6.3.2.49", "l": "\"L-alanine--L-anticapsin ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191402", "l": "Reduction of presqualene diphosphate to form squalene (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47111", "l": "cholate + taurine <=> H2O + taurocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204981", "l": "14-3-3epsilon attentuates NADE-related apoptosis (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42880", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermine = H(+) + N(4)-aminopropylspermine + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31026", "l": "squalene <=> dammara-20,24-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781840", "l": "ERCC6 binds stalled RNA Pol II (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10100", "l": "a sterol ester + H2O = a fatty acid + a sterol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56324", "l": "(DNA)-(deoxyribonucleoside 5'-methylphosphotriester) + L-cysteinyl-[protein] = (DNA)-(deoxyribonucleoside 5'-phosphate) + H(+) + S-methyl-L-cysteinyl-[protein]"}, {"i": "EC:2.1.1.n11", "l": "\"Methylphosphotriester-DNA--[protein]-cysteine S-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-708349", "l": "Activated NOD2 oligomerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49290", "l": "(R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+) => (R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.1", "l": "\"Purine-nucleoside phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433506", "l": "Phosphorylation of APS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64700", "l": "1-phenylethanol + NAD(+) = acetophenone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22018", "l": "arsenite + glutathionyl-S-S-[glutaredoxin] + H2O => [glutaredoxin]-dithiol + arsenate + glutathione + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12134", "l": "ADP + Cd(2+)(out) + H(+) + phosphate => ATP + Cd(2+)(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450063", "l": "Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44193", "l": "2-methylhexadecanoate + ATP + CoA => 2-methylhexadecanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63403", "l": "Fe(II)-hydroxyheme i <=> Fe(II)-heme a + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668415", "l": "VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72143", "l": "Lariat Formation and 5'-Splice Site Cleavage (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38265", "l": "2-methylfumaryl-CoA + H2O => (2R,3S)-beta-methylmalyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51488", "l": "archaetidylserine + H(+) = archaetidylethanolamine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25333", "l": "(R)-carnitine + NAD(+) <=> 3-dehydrocarnitine + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64473", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + S-adenosyl-L-methionine => (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40690", "l": "1-hexadecanoylglycerone 3-phosphate + tetradecan-1-ol <=> 1-O-tetradecylglycerone 3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613648", "l": "SOX10 dimer binds the POU3F1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20841", "l": "H(+) + L-histidine => CO2 + histamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16206", "l": "H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] => N(6)-(D-fructosyl)-L-lysyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36192", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + choline => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46264", "l": "2 [Fe(II)-cytochrome b5] + an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641205", "l": "RSPO:LGR binds ZNRF3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620723", "l": "VGF gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696491", "l": "CNTF binds CNTFR complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37948", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009024", "l": "tagatose-6-phosphate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30514", "l": "2-demethylmenaquinone-8 + H(+) + NADPH <=> 2-demethylmenaquinol-8 + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177922", "l": "EGFR dimerization (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47124", "l": "glycine + hexacosanoate = H2O + N-hexacosanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419166", "l": "GEFs activate RhoA,B,C (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22304", "l": "A + D-fructose = 5-dehydro-D-fructose + AH2"}, {"i": "EC:1.1.99.11", "l": "\"Fructose 5-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874078", "l": "PTK2 autophosphorylates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.2", "l": "\"Acid phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54343", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine <=> 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45881", "l": "3-methylundecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17069", "l": "all-trans-undecaprenyl diphosphate + H2O = all-trans-undecaprenyl phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140563", "l": "UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37960", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19661", "l": "D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate + H(+) + NADH"}, {"i": "EC:1.1.1.17", "l": "\"Mannitol-1-phosphate 5-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24681", "l": "5,6,7,8-tetrahydromethanopterin + formaldehyde <=> 5,10-methylenetetrahydromethanopterin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35049", "l": "AMP + H2O + Mo-molybdopterin => adenylyl-molybdopterin + H(+) + molybdate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35766", "l": "8-O-methyldihydrosterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> aflatoxin B2 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58003", "l": "(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rg3 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45837", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61310", "l": "germacra-1(10),4,11(13)-trien-12-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-(R)-germacrene A + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420883", "l": "Opsins act as GEFs for G alpha-t (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.5", "l": "\"Type III site-specific deoxyribonuclease\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102844", "l": "1-18:2-2-16:1-monogalactosyldiacylglycerol desaturase activity (SN2-16:2 forming)"}, {"i": "MetaCyc:RXN-8305"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30955", "l": "9,9'-di-cis-zeta-carotene + 2 a quinone = 7,7',9,9'-tetra-cis-lycopene + 2 a quinol"}, {"i": "EC:1.3.5.6", "l": "\"9,9'-di-cis-zeta-carotene desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64310", "l": "acetoacetate + L-alanine => 3-aminobutanoate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56239", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35030", "l": "ATP + H2O + tungstate(in) <=> ADP + H(+) + phosphate + tungstate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264458", "l": "Proteasome mediated degradation of COP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209097", "l": "ARM binds to APC and AXN in the 'destruction complex' (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.2", "l": "\"DNA ligase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18592", "l": "[glutamine synthetase]-L-tyrosine + ATP <=> [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031964", "l": "beta-alanyl-histamine hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51458", "l": "(9Z)-octadecenoate + L-isoleucine => H2O + N-(9Z-octadecenoyl)-L-isoleucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48285", "l": "globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose => globoside NOR1 (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177923", "l": "Sustained activation of SRC kinase by SHP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864569", "l": "WWOX binds TFAP2C (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37862", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA <=> 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034867", "l": "2,4,4-trimethylpent-2-enoyl-CoA hydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191402", "l": "Reduction of presqualene diphosphate to form squalene (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953111", "l": "E2F6 binds TFDP1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45454", "l": "ethanolamine + tetradecanoate => H2O + N-tetradecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50658", "l": "2-(2-methylsulfanyl)ethylmaleate + H2O => 3-(2-methylsulfanyl)ethylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349455", "l": "Phosphorylation of MDM4 by ATM (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39289", "l": "[methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine => [Co(I) trimethylamine-specific corrinoid protein] + H(+) + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852362", "l": "GTSE1 binds CDKN1A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706354", "l": "Ubiquitination of FLT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044594", "l": "17-beta-hydroxysteroid dehydrogenase (NAD+) activity"}, {"i": "RHEA:24612", "l": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48717", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => 13-oxo-(9Z,11E)-octadecadienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50857", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63480", "l": "NADP(+) + prostaglandin F2alpha = 15-oxoprostaglandin F2alpha + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19340", "l": "2 hydroxylamine + 2 NAD(+) <=> 2 H(+) + hyponitrous acid + 2 NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63900", "l": "2 3-(4-hydroxyphenyl)pyruvate + H(+) = (2S)-2-(4-hydoxybenzyl)-3-(4-hydroxyphenyl)-2-furonol carboxylate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12058", "l": "4-phospho-D-erythronate + 2 H(+) + NADH => D-erythrose 4-phosphate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102905", "l": "valencene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63154", "l": "a fatty acid + taurine => an N-fatty acyl-taurine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49920", "l": "(R)-carnitine(out) + O-octanoyl-(R)-carnitine(in) = (R)-carnitine(in) + O-octanoyl-(R)-carnitine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9619376", "l": "CAMK1 binds calmodulin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49059", "l": "asperlicin C + H(+) + NADPH + O2 <=> asperlicin E + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11270", "l": "H(+) + hydrogen sulfide + NH4(+) + pyruvate => D-cysteine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035885", "l": "exochitinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17444", "l": "2-oxoglutarate + L-cysteine <=> 2-oxo-3-sulfanylpropanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614614", "l": "Cysteine is degraded to serine and H2S (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23990", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate => (2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10113", "l": "L-homocysteine + L-serine => H2O + L,L-cystathionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58033", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109858", "l": "MAP2K2 binds MAPK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10456", "l": "acetyl-CoA + D-maltose = 1-O-acetylmaltose + CoA"}, {"i": "EC:2.3.1.79", "l": "\"Maltose O-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0099510", "l": "calcium ion binding involved in regulation of cytosolic calcium ion concentration"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050511", "l": "undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"}, {"i": "EC:2.4.1.227", "l": "\"Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54793", "l": "[nsP1 protein]-L-histidine + N(7)-methyl-GTP => [nsP1 protein]-N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidine + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47079", "l": "17beta-hydroxyandrosta-1,4-dien-3-one + H(+) + NADPH <=> 17beta-hydroxy-5beta-androst-1-en-3-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665761", "l": "FMNL3 binds RHOC:GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59487", "l": "2 [Fe(III)cytochrome c] + arsenite + H2O <=> 2 [Fe(II)cytochrome c] + arsenate + 3 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61881", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-12-hydroperoxy-20-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30151", "l": "FADH2 + NADP(+) = FAD + 2 H(+) + NADPH"}, {"i": "EC:1.5.1.45", "l": "\"FAD reductase (NAD(P)H)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022934", "l": "GAD1 gene expression is stimulated by MECP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15454", "l": "S-adenosyl-L-methionine + sarcosine => H(+) + N,N-dimethylglycine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047022", "l": "7-beta-hydroxysteroid dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12979", "l": "creatine + phosphate => H2O + N-phosphocreatine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42135", "l": "isonocardicin C <=> nocardicin C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806629", "l": "Formation of tonofilament bundles (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14598", "l": "a CDP-1,2-diacyl-sn-glycerol + choline => a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58682", "l": "AH2 + FAD + H(+) => A + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57672", "l": "(+)-5-epi-aristolochene + O2 + reduced [NADPH--hemoprotein reductase] = 2beta-hydroxy-5-epi-aristolochene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17301", "l": "ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] = ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase]"}, {"i": "EC:2.7.11.4", "l": "\"[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65365", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O => a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44103", "l": "H2O + NAD(+) + octanal <=> 2 H(+) + NADH + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61764", "l": "stevioside + UDP-alpha-D-glucose = H(+) + rebaudioside E + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050158", "l": "orotate reductase (NADPH) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602484", "l": "Activation of proMMP11 by FURIN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693608", "l": "Initial resection of double-strand break ends (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690785", "l": "BAP1 binds Ub-HCFC1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1299338", "l": "Activation of TRESK (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022831", "l": "narrow pore, gated channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351229", "l": "N-acetylated spermine (cytosol)=>N-acetylated spermine (peroxisomal) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047294", "l": "phosphoglycerol geranylgeranyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805740", "l": "SETD8 methylates TP53 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74992", "l": "Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50033", "l": "H2O + hexadecanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + hexadecanoyl-4'-phosphopantetheine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60139", "l": "a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 <=> a (8S,9R)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169895", "l": "Crk's SH3 domain engages C3G (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005001", "l": "transmembrane receptor protein tyrosine phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43762", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[ribosomal protein bL12] => acetyl-CoA + N-terminal L-seryl-[ribosomal protein bL12]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62137", "l": "dGMP + GTP => dGDP + GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54621", "l": "2-oxoglutarate + eicosanoyl-CoA + O2 => 2-hydroxyeicosanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.72", "l": "\"IgA-specific serine endopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60748", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-pyrethrolone = CoA + pyrethrin II"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38359", "l": "2 H(+) + hydrogen sulfide + sulfite + ubiquinone-10 = thiosulfate + ubiquinol-10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-983153", "l": "E1 mediated ubiquitin activation (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111879", "l": "PIP2 hydrolysis (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663264", "l": "RORA, EP300 bind CPT1A gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "72.610931868743009", "identifiers": [{"i": "GO:0004659", "l": "prenyltransferase activity"}, {"i": "REACT:R-HSA-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14392", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014454", "l": "RHOG translocates to the ER membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28036", "l": "[thioredoxin]-dithiol + ADP => [thioredoxin]-disulfide + dADP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871260", "l": "YAP1 binds TEAD2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0045296", "l": "cadherin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804527", "l": "INTL1 binds bacterial glycans (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:1990238", "l": "double-stranded DNA endodeoxyribonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730840", "l": "Activation of RAC1 by VAV (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16954", "l": "2-oxoglutarate + N(2)-succinyl-L-ornithine => L-glutamate + N-succinyl-L-glutamate 5-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11750", "l": "4-fluoro-L-threonine + acetaldehyde => fluoroacetaldehyde + L-threonine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047469", "l": "4-carboxymethyl-4-methylbutenolide mutase activity"}, {"i": "RHEA:19237", "l": "4-carboxymethyl-4-methylbut-2-en-1,4-olide = 4-carboxymethyl-3-methylbut-2-en-1,4-olide"}, {"i": "EC:5.4.99.14", "l": "\"4-carboxymethyl-4-methylbutenolide mutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158313", "l": "factor XII -> factor XIIa (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21683", "l": "(2S)-2-hydroxyphytanate + O2 <=> 2-oxophytanate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44493", "l": "3,4-dihydroxy-5-all-trans-decaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015152", "l": "glucose-6-phosphate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847977", "l": "FRK phosphorylates PTEN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "81.790986234327661", "identifiers": [{"i": "GO:0048020", "l": "CCR chemokine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34969", "l": "sn-glycerol 3-phosphate(out) => sn-glycerol 3-phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853322", "l": "Plasma membrane FGFR1 fusions dimerize (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44899", "l": "a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose <=> H(+) + N-(2-hydroxyacyl)-beta-D-galactosyl-sphing-4-enine + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18609", "l": "carbamoyl phosphate + N(2)-acetyl-L-ornithine = H(+) + N(2)-acetyl-L-citrulline + phosphate"}, {"i": "EC:2.1.3.9", "l": "\"N-acetylornithine carbamoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31359", "l": "FMNH2 + nitrilotriacetate + O2 = ammoniodiacetate + FMN + glyoxylate + H2O"}, {"i": "EC:1.14.14.10", "l": "\"Nitrilotriacetate monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37110", "l": "H2O + N(7)-methyl-GMP <=> N(7)-methylguanosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.-", "l": "\"Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compounds\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000034", "l": "adenine deaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202233", "l": "Inactivation of Lck by Csk (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58158", "l": "ADP + H(+) + 4 Na(+)(out) + phosphate => ATP + H2O + 4 Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019810", "l": "putrescine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212614", "l": "Glutamine transport from astrocytes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13713", "l": "a ubiquinone + succinate = a ubiquinol + fumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061812", "l": "cyclic ADP-ribose hydrolase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35576", "l": "(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] => (1'S,5'R)-5'-hydroxyaverantin + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.99.-", "l": "\"In other compounds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32832", "l": "cob(III)alamin(in) => cob(III)alamin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244402", "l": "botB:SYT:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047579", "l": "4-hydroxymandelate oxidase activity"}, {"i": "MetaCyc:4-HYDROXYMANDELATE-OXIDASE-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047553", "l": "2-oxoglutarate synthase activity"}, {"i": "RHEA:17297", "l": "2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA"}, {"i": "EC:1.2.7.3", "l": "\"2-oxoglutarate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209828", "l": "Tryptophan is hydroxylated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20466", "l": "[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036970", "l": "NTRK3 activates RAS through SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11094", "l": "dihydroxyacetone phosphate + H(+) + NADH => NAD(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964773", "l": "OXGR1 binds 2OG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21464", "l": "2 H(+) + H2O + thiocyanate = carbonyl sulfide + NH4(+)"}, {"i": "EC:3.5.5.8", "l": "\"Thiocyanate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15169", "l": "H2O + N-succinyl-L-glutamate = L-glutamate + succinate"}, {"i": "EC:3.5.1.96", "l": "\"Succinylglutamate desuccinylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15909", "l": "2-oxoglutarate + O2 + taurine = aminoacetaldehyde + CO2 + H(+) + succinate + sulfite"}, {"i": "EC:1.14.11.17", "l": "\"Taurine dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14930", "l": "NAD(+) + testosterone => androst-4-ene-3,17-dione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168849", "l": "tBID binds to inactive BAX protein (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015218", "l": "pyrimidine nucleotide transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12675", "l": "a nitrile + H2O => an aliphatic amide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975594", "l": "PLB1 hydrolyses RPALM to atROL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29101", "l": "a menaquinol + 4 H(+)(out) + NAD(+) => a menaquinone + 5 H(+)(in) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40826", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42443", "l": "L-aspartate + NAD(+) <=> H(+) + iminosuccinate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12360", "l": "(2E)-2-methylbut-2-enoyl-CoA + 13-hydroxylupanine = 13-(2-methylcrotonoyloxy)lupanine + CoA"}, {"i": "EC:2.3.1.93", "l": "\"13-hydroxylupanine O-tigloyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29308", "l": "FMNH2 + methanesulfonate + O2 => FMN + formaldehyde + 2 H(+) + H2O + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388829", "l": "SHP2 phosphatase binds CTLA-4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9733973", "l": "Bile salts bind FABP6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857555", "l": "EGFR phosphorylates GPNMB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21033", "l": "glucuronate acceptor + UDP-alpha-D-glucuronate => acceptor beta-D-glucuronoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.135", "l": "\"1-hydroxy-2-naphthoate hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18559", "l": "1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA => 1-O-alkyl-sn-glycero-3-phosphate + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31240", "l": "4 H(+) + uroporphyrinogen I => 4 CO2 + coproporphyrinogen I"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1606273", "l": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32873", "l": "a carboxylate + glycerol + H(+) => a 2-acylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36176", "l": "1-O-alkylglycerone 3-phosphate + H(+) + NADPH => 1-O-alkyl-sn-glycero-3-phosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956031", "l": "NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48943", "l": "an L-aminoacyl-L-amino acid + H2O <=> 2 an L-alpha-amino acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29999", "l": "ATP + H2O + spermidine(out) = ADP + H(+) + phosphate + spermidine(in)"}, {"i": "EC:7.6.2.11", "l": "\"ABC-type polyamine transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432956", "l": "BP230 is recruited to the hemidesmosome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46997", "l": "6-hydroxy-N-methylmyosmine + H2O => 6-hydroxypseudooxynicotine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030411", "l": "scytalone dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-378956", "l": "Luteinizing hormone is a heterodimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694462", "l": "ABHD6,12 hydrolyse 3AG (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381087", "l": "Dimerization of PERK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53813", "l": "cholestanol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-26-hydroxycholestanol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56119", "l": "2-all-trans-decaprenylphenol + H(+) + NADPH + O2 <=> 3-(all-trans-decaprenyl)benzene-1,2-diol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696266", "l": "RND2 binds effectors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202241", "l": "Recruitment of SLP-76 to Gads (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61495", "l": "a sphingoid base + an ultra-long-chain fatty acyl-CoA <=> an N-(ultra-long-chain-acyl)-sphingoid base + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39384", "l": "3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67114", "l": "H(+) + N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31856", "l": "(S)-2,3-epoxysqualene => achilleol B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198508", "l": "malate + NAD+ <=> oxaloacetate + NADH + H+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36186", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + CDP-choline <=> a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-947535", "l": "Cyclisation of GTP to precursor Z (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20793", "l": "ATP + L-lysine + tRNA(Lys) => AMP + diphosphate + L-lysyl-tRNA(Lys)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28924", "l": "H(+)(in) + L-phenylalanine(in) => H(+)(out) + L-phenylalanine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022141", "l": "Prolysyl oxidase activation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62067", "l": "2-deoxy-D-glucose 6-phosphate + NAD(+) <=> 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1605797", "l": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60379", "l": "D-glucose(out) <=> D-glucose(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202500", "l": "Activation of IKK complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56143", "l": "H2O + S-adenosyl-L-methionine <=> adenosine + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202248", "l": "Phosphorylation of PLC-gamma1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.86", "l": "\"Limulus clotting enzyme\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52630", "l": "a fatty acid + an L-alpha-amino acid => an N-fatty-acyl-L-alpha-amino acid + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879562", "l": "SLCO2B1 has a narrow substrate specificity (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59082", "l": "2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+) => bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14750", "l": "1-hydroxy-2-naphthoate + O2 => (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53729", "l": "H2O + N-acetyl-D-muramate 6-phosphate => N-acetyl-D-muramate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60026", "l": "(R,R)-chrysanthemol + diphosphate => (R,R)-chrysanthemyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4647613", "l": "Transcriptional activation of CDKN1A by TP53 is inhibited by EP400 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15146", "l": "D-maltose => alpha,alpha-trehalose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64624", "l": "(2E)-geraniol + acetyl-CoA = (2E)-geranyl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41835", "l": "(2E)-hexenoyl-[ACP] + H(+) + NADPH <=> hexanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3095901", "l": "ABCC1 transports cytosolic Cbl to extracellular region (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54538", "l": "a very long-chain fatty acyl-CoA + AMP + diphosphate => a very long-chain fatty acid + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19749", "l": "[(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->3)-alpha-D-glucosyl](n+1) + H(+) + UDP"}, {"i": "EC:2.4.1.183", "l": "\"Alpha-1,3-glucan synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163320", "l": "Association of mTERF with the termination sequence (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29492", "l": "(2E,6E)-farnesyl diphosphate => cis-muurola-4(14),5-diene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54578", "l": "an adenosine in tRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15110", "l": "2-dehydro-3-deoxy-D-gluconate + NADP(+) => (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433456", "l": "Recruitment of STATs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "65.48928698272745", "identifiers": [{"i": "GO:0042626", "l": "ATPase-coupled transmembrane transporter activity"}, {"i": "REACT:R-HSA-2161506", "l": "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29905", "l": "ADP + D-ribose(in) + H(+) + phosphate => ATP + D-ribose(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39798", "l": "7beta-hydroxycholesterol(in) + ATP + H2O <=> 7beta-hydroxycholesterol(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607750", "l": "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23445", "l": "(S)-lactate + NAD(+) => H(+) + NADH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56094", "l": "biliverdin IXalpha + reduced coenzyme F420-(gamma-Glu)(n) => bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22165", "l": "globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => globoside Forssman (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59062", "l": "(20S)-ginsenoside Rh2 + D-glucose => (20S)-ginsenoside Rg3 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40115", "l": "H2O + hexanoyl-CoA = CoA + H(+) + hexanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005334", "l": "norepinephrine:sodium symporter activity"}, {"i": "REACT:R-HSA-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63089", "l": "a ribonucleotide in U6 snRNA + S-adenosyl-L-methionine => a 2'-O-methylribonucleotide in U6 snRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2429643", "l": "NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38742", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47289", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48104", "l": "N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60806", "l": "CO2 + gibberellin A17 + H(+) + succinate => 2-oxoglutarate + gibberellin A19 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28837", "l": "citrate(in) + succinate(out) => citrate(out) + succinate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051431", "l": "corticotropin-releasing hormone receptor 2 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39318", "l": "(3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA <=> (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58250", "l": "ADP-D-ribose + H(+) + L-glutamyl-[protein] => 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844610", "l": "NLRP3 recruits PYCARD (ASC) via a PYD-PYD interaction (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63578", "l": "ecdysone + phosphate => ecdysone 22-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55869", "l": "(S)-lactate + O2 => H2O2 + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28039", "l": "[thioredoxin]-disulfide + dCDP + H2O => [thioredoxin]-dithiol + CDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39650", "l": "AH2 + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + H(+) + L-methionine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634390", "l": "ERBB2 homodimer phosphorylates SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018129", "l": "peptidyl-oxazoline dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008959", "l": "phosphate acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39731", "l": "3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52668", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate = [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76052", "l": "Binding of TFIIIA To type 1 Promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25989", "l": "(5R)-albaflavenol + H(+) + NADPH + O2 => albaflavenone + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "76.412572999466406", "identifiers": [{"i": "GO:0033293", "l": "monocarboxylic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28435", "l": "(9Z)-hexadecenoyl-(Kdo)2-lipid IVA + tetradecanoyl-[ACP] => ((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26545", "l": "(R)-piperazine-2-carboxamide + H2O <=> (R)-piperazine-2-carboxylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209840", "l": "Two DITs combine to form thyroxine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2574845", "l": "AJUBA binds centrosome-associated AURKA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61998", "l": "CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein] => L-lysyl-[protein] + lactoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30832", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-hex-4-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44538", "l": "1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40579", "l": "1-O-(1Z)-hexadecenyl-2 (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450474", "l": "MK2 phosphorylates BRF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674095", "l": "PDGFRs bind type II TKI (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20166", "l": "H2O + N(5)-acyl-L-ornithine ester => an alcohol + H(+) + N(5)-acyl-L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52642", "l": "(2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + CoA => (2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112396", "l": "Separation of elongating transcript from template (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201611", "l": "Caspase-mediated cleavage of Rock-1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25915", "l": "A + H2O + quinolin-5-ol <=> 5-hydroxyquinolin-2(1H)-one + AH2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160004", "l": "poly-ADP-D-ribose modification-dependent protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37848", "l": "13-dihydrodaunorubicin + H(+) + NADPH + O2 => daunorubicin + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0050738", "l": "fructosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35787", "l": "paromamine + UDP-alpha-D-kanosamine = H(+) + kanamycin C + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21549", "l": "H2O + N(6)-acetyl-L-lysyl-[alpha-tubulin] => acetate + L-lysyl-[alpha-tubulin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24010", "l": "ADP + H(+) + N(omega)-phosphohypotaurocyamine => ATP + hypotaurocyamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18807", "l": "[DsbA protein]-dithiol + [protein]-disulfide => [DsbA protein]-disulfide + [protein]-dithiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27720", "l": "inosine + phosphate => H2O + IMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52970", "l": "H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP => hyocholate + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59270", "l": "AH2 + formaldehyde + L-lysyl-[protein] => A + H2O + N(6)-methyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46988", "l": "(R)-6-hydroxynicotine + O2 = 6-hydroxy-N-methylmyosmine + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64277", "l": "chrysophanol-9-anthrone + O2 => chrysophanol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62139", "l": "dGMP + GTP <=> dGDP + GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19084", "l": "1-haloalkane + H2O <=> a halide anion + a primary alcohol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14256", "l": "guanosine 3',5'-bis(diphosphate) + H2O <=> diphosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018496", "l": "2,6-dihydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863718", "l": "AGFG1 binds VAMP7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19803", "l": "3'-dephospho-CoA + diphosphate => ATP + D-pantetheine 4'-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030791", "l": "arsenite methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57522", "l": "3beta-hydroxy-15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 15,16-epoxydolabrene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60156", "l": "ATP + D-galactose(out) + H2O = ADP + D-galactose(in) + H(+) + phosphate"}, {"i": "EC:7.5.2.11", "l": "\"ABC-type D-galactose transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29860", "l": "5'-deoxyadenosine + H2O => 5-deoxy-D-ribose + adenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12651", "l": "H(+) + L-rhamnono-1,4-lactone + NADH => L-rhamnofuranose + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084903", "l": "Collagen types VI, IX bind integrin alpha10beta1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66817", "l": "2 Na(+)(in) + tetrahydroxoborate(in) => 2 Na(+)(out) + tetrahydroxoborate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28463", "l": "pyridoxal(in) => pyridoxal(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31100", "l": "2-methylpropanoyl-CoA + FAD + H(+) => (2E)-2-methylpropenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57142", "l": "1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20808", "l": "acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-7-O-acetylneuraminate"}, {"i": "RHEA:26043", "l": "acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-9-O-acetylneuraminate"}, {"i": "EC:2.3.1.45", "l": "\"N-acetylneuraminate 7-O(or 9-O)-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18326", "l": "(2E,6E)-farnesyl diphosphate => (+)-amorpha-4,11-diene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24549", "l": "an N(6)-acyl-L-lysine + H2O => a carboxylate + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64551", "l": "N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] <=> (3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47704", "l": "H(+) + iso-precytochalasin + NADPH + O2 = cytochalasin Z16 + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21764", "l": "heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.18", "l": "\"Heme oxygenase (biliverdin-producing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59582", "l": "CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester => hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61618", "l": "formaldehyde + H2O + N-methyl-L-proline + NAD(+) => H(+) + L-proline betaine + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853444", "l": "AURKA phosphorylates PHLDA1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098699", "l": "structural constituent of presynaptic actin cytoskeleton"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264679", "l": "Serum albumin binds 2-lysophosphatidylcholine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614591", "l": "Excess cysteine yields lanthionine and H2S (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807585", "l": "BPI binds LPS on the bacterial surface (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37669", "l": "3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684008", "l": "NBN binds KPNA2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13292", "l": "dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64278", "l": "chrysophanol + H2O => chrysophanol-9-anthrone + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141439", "l": "Release of activated MAD2 from kinetochores (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34570", "l": "CDP-alpha-D-paratose + NADP(+) <=> CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10452", "l": "2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + O2 + reduced [NADPH--hemoprotein reductase] = (R)-dihydrocamalexate + 2 H(+) + 2 H2O + hydrogen cyanide + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62936", "l": "H2O + N(4)-acetyl-2'-deoxycytidine = 2'-deoxycytidine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088220", "l": "Endorepellin binds alpha2beta1 integrin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210947", "l": "pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2129357", "l": "Fibrillin C-terminal processing (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52718", "l": "a long-chain primary fatty alcohol + CoA + 2 NADP(+) => a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730899", "l": "Oligomerization of BCL10 and MALT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43778", "l": "an N-(acyl)-sphingosylphosphocholine(out) => an N-(acyl)-sphingosylphosphocholine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31755", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA + H2O = 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde"}, {"i": "EC:3.3.2.12", "l": "\"Oxepin-CoA hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42282", "l": "11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034550", "l": "dimethylarsinate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.86"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592278", "l": "Autocatalytic activation of proMMP2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937613", "l": "CRHBP binds CRH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33352", "l": "hexacosanoyl-CoA + sphinganine => CoA + H(+) + N-hexacosanoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635846", "l": "GLI proteins bind GLI1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13943", "l": "ADP + D-glyceraldehyde 3-phosphate + H(+) => ATP + D-glyceraldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43588", "l": "globoside NORint + UDP-alpha-D-galactose = globoside NOR2 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102966", "l": "arachidoyl-CoA:1-dodecanol O-acyltransferase activity"}, {"i": "MetaCyc:RXN-9356"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42329", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.27"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32248", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) => (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14472", "l": "2-aminomuconate 6-semialdehyde + H2O + NAD(+) <=> (2Z,4E)-2-aminomuconate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34291", "l": "2',4,4',6'-tetrahydroxychalcone + UDP-alpha-D-glucose = 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202174", "l": "Activation of ZAP-70 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18566", "l": "19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine => 9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0016890", "l": "site-specific endodeoxyribonuclease activity, specific for altered base"}, {"i": "EC:3.1.25.-", "l": "\"Site-specific endodeoxyribonucleases specific for altered bases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33826", "l": "3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvate + H(+) + NADH <=> NAD(+) + tetrahydro-4-hydroxyphenylpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-517674", "l": "p-S158,221-HuR binds mRNA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008397", "l": "sterol 12-alpha-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351207", "l": "Spermine  => N-acetylated spermine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44245", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61568", "l": "an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O = an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17578", "l": "ADP-D-glycero-beta-D-manno-heptose => ADP-L-glycero-beta-D-manno-heptose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357479", "l": "p-AXL binds PI3K (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15371", "l": "2-carboxy-cis,cis-muconate + 2 H(+) => 2,3-dihydroxybenzoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369052", "l": "ABCAs mediate lipid influx (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22381", "l": "[(1->4)-alpha-D-galacturonosyl methyl ester](n) + n H2O => [(1->4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52839", "l": "H(+) + indole + NADH + O2 <=> H2O + indoxyl + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16608", "l": "dodecanoyl-CoA + H2O + oxaloacetate <=> (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46388", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S,25R)-24,26-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45579", "l": "(2R)-ethylmalonyl-CoA <=> (2S)-methylsuccinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0033731", "l": "arogenate dehydrogenase [NAD(P)+] activity"}, {"i": "MetaCyc:1.3.1.79-RXN"}, {"i": "EC:1.3.1.79", "l": "\"Arogenate dehydrogenase (NAD(P)(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190519", "l": "Internalization of gap junction plaques (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36415", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.98", "l": "\"Diphthine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54544", "l": "1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine = 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62242", "l": "a thymine-cytidine dinucleotide in DNA => a thymidine(6-4)cytidine in DNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34598", "l": "H(+) + isopentadecanoyl-CoA + L-serine <=> 3-dehydro-15-methylhexadecasphinganine + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64681", "l": "benzoyl-CoA + ethanol => CoA + ethyl benzoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022911", "l": "CSPG is secreted (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-179417", "l": "Multiubiquitination of Nek2A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047828", "l": "D-lyxose ketol-isomerase activity"}, {"i": "RHEA:14201", "l": "D-lyxose = D-xylulose"}, {"i": "EC:5.3.1.15", "l": "\"D-lyxose ketol-isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8878654", "l": "ACP6 hydrolyses MYS-LPA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40711", "l": "1-octadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604752", "l": "Initial activation of proMMP13 by MMP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23611", "l": "H(+) + H2O + N-isopropylammelide <=> cyanurate + isopropylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35439", "l": "CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine = archaetidylserine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54936", "l": "(2E)-decenoyl-[ACP] + H(+) + NADH = decanoyl-[ACP] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16521", "l": "H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADH + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008784", "l": "alanine racemase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21650", "l": "3-phenylpyruvate + CO2 + H2O => H(+) + prephenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675947", "l": "TNFSF18 binds TNFRSF18 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30416", "l": "H(+) + 2 NADPH + O2 + octadecanal => formate + H2O + heptadecane + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.99"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698926", "l": "HCMV Genome Replication Completion (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48597", "l": "1,2-didecanoylglycerol + H2O => decanoate + decanoylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33282", "l": "L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905055", "l": "calcium:cation antiporter activity involved in regulation of presynaptic cytosolic calcium ion concentration"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730862", "l": "Autophosphorylation of LYN kinase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373073", "l": "Receptors CCR1, 2 and 8 bind CCL16 ligand (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12654", "l": "(S)-malate + NAD(+) => CO2 + NADH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196417", "l": "Reduction of desmosterol to cholesterol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693575", "l": "DNA-PKcs autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051800", "l": "phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25493", "l": "(2E)-geranyl diphosphate => (-)-beta-phellandrene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60955", "l": "(E)-5-hydroxyferulate + S-adenosyl-L-methionine <=> E-sinapate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54978", "l": "(3S)-hydroxytetradecanoate + CoA + H(+) => (3S)-hydroxytetradecanoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29757", "l": "(R)-lipoate(out) => (R)-lipoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54400", "l": "1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35282", "l": "acetyl-CoA + hexadecanoyl-CoA <=> 3-oxooctadecanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17684", "l": "3-hydroxy-2-methylpropanoate + NAD(+) <=> 2-methyl-3-oxopropanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30390", "l": "GDP-alpha-D-glucose + phosphate <=> alpha-D-glucose 1-phosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39777", "l": "17,18-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199425", "l": "PHLPP dephosphorylates S473 in AKT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23292", "l": "ATP + L-lombricine = ADP + H(+) + N-phospho-L-lombricine"}, {"i": "EC:2.7.3.5", "l": "\"Lombricine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371467", "l": "SIRT1 deacetylates HSF1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37488", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphocholine => 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56110", "l": "2'-hydroxygenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => genistein + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015193", "l": "L-proline transmembrane transporter activity"}, {"i": "REACT:R-HSA-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16529", "l": "ADP + H(+) + sulfate = adenosine 5'-phosphosulfate + phosphate"}, {"i": "EC:2.7.7.5", "l": "\"Sulfate adenylyltransferase (ADP)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961840", "l": "E2F1 binds the CCNE1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36388", "l": "carbamoyl adenylate + kanamycin A => 6''-O-carbamoylkanamycin A + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35202", "l": "(S,S)-tartrate(out) <=> (S,S)-tartrate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.11", "l": "\"Ribonuclease Z\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202726", "l": "F11R dimerises (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981355", "l": "RASA1 binds RAS:GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810239", "l": "SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41287", "l": "H2O + N-tetradecanoylsphing-4-enine = sphing-4-enine + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389976", "l": "Beta-tubulin:GTP:Cofactor D+alpha-tubulin:GTP:Cofactor E-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.40", "l": "\"Serralysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730843", "l": "Phosphorylation of LAT by p-SYK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74707", "l": "Binding of IRS to insulin receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017131", "l": "uridine-rich cytoplasmic polyadenylylation element binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011083", "l": "ROBO1 gene expression is inhibited by LHX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4167511", "l": "HLCS biotinylates ACACB (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30056", "l": "L-allo-threonine + NADP(+) => (2S)-2-amino-3-oxobutanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22494", "l": "formamide + L-glutamate => H2O + N-formimidoyl-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64832", "l": "3-hydroxybenzyl alcohol + benzoyl-CoA = 3-hydroxy-benzyl benzoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42310", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51966", "l": "2-hydroxy-2-methylpropanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-methylpropanenitrile + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53079", "l": "cytidine(34) in mitochondrial tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(34) in mitochondrial tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802930", "l": "Dimerization of BRAF V600E splice variants contributes to BRAF inhibitor resistance (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54595", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + GTP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.120"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19010", "l": "a 3-acylpyruvate + H2O => a carboxylate + H(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57572", "l": "7-deoxyloganetic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] = 7-deoxyloganetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371353", "l": "Soluble TNF-alpha binds TNFR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16998", "l": "3'-phosphoadenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol => 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47950", "l": "phosphate + thiamine => H2O + thiamine phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48249", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0) => CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.55", "l": "\"Lytic starch monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-171141", "l": "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086410", "l": "CDK1 phosphorylates BORA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25018", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18347", "l": "a cis-alkene + CO2 => a cis-3-alkyl-4-alkyloxetan-2-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14342", "l": "2-oxoglutarate + glyoxylate + H(+) => 2-hydroxy-3-oxoadipate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158942", "l": "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375160", "l": "NCAM1 binds to ATP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43150", "l": "H(+) + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine => adenosine(9) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928578", "l": "EPH receptors autophosphorylate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10367", "l": "2-oxoglutarate + dodecanoyl-CoA + H2O <=> (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53690", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180602", "l": "Association of Vif with APOBEC3G (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25800", "l": "H2O + N(1)-acetylspermine + O2 = 3-acetamidopropanal + H2O2 + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66162", "l": "CoA + H(+) + N-hexanoyltyramine => hexanoyl-CoA + tyramine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015046", "l": "rubredoxin-NADP+ reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48874", "l": "a gentamycin 2''-phosphate + GDP + H(+) => a gentamycin + GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15503", "l": "2-oxoglutarate + H(+) + L-glutamine + NADPH => 2 L-glutamate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-453342", "l": "PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005173", "l": "stem cell factor receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190260", "l": "FGFR2b binds to FGF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035227", "l": "TXN2 binds CysS248-MPST (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614933", "l": "ACEIs bind ACE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75891", "l": "Abortive Initiation After Second Transition (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66138", "l": "CoA + H(+) + N-acetyltyramine => acetyl-CoA + tyramine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191784", "l": "snRNA Cap hypermethylation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605768", "l": "Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610722", "l": "CK1 phosphorylates p-GLI3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59307", "l": "3'-phosphoadenylyl sulfate + firefly L-luciferin <=> adenosine 3',5'-bisphosphate + firefly L-sulfoluciferin + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53782", "l": "beta-muricholoyl-CoA + lithocholate => beta-muricholate + lithocholoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51625", "l": "formate + GTP + H(+) => CO2 + dGTP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8948757", "l": "AKT phosphorylates MKRN1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33051", "l": "choline + NAD(+) = betaine aldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.135", "l": "\"Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987223", "l": "IL10RB binds TYK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33233", "l": "heme d cis-diol => H2O2 + heme b"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16410", "l": "1,2-dihydrovomilenine + NADP(+) => H(+) + NADPH + vomilenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086410", "l": "CDK1 phosphorylates BORA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34563", "l": "CDP-alpha-D-abequose + NADP(+) = CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH"}, {"i": "EC:1.1.1.341", "l": "\"CDP-abequose synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070644", "l": "vitamin D response element binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433415", "l": "Activation of RAC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61746", "l": "stevioside + UDP => steviolbioside + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005300", "l": "high-affinity tryptophan transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050421", "l": "nitrite reductase (NO-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66782", "l": "N-acetyl-D-glucosamine + N-acetyl-D-muramate 6-phosphate => 6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707659", "l": "Hemes:LY96 activates TLR4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866269", "l": "ARRB bind GPCRs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9660557", "l": "RAS:GTP binds RAL GDS proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56340", "l": "ent-isokauren-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-isokaurene-2beta,3beta-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050554", "l": "abietadiene synthase activity"}, {"i": "RHEA:13873", "l": "(+)-copalyl diphosphate = abieta-7,13-diene + diphosphate"}, {"i": "EC:4.2.3.18", "l": "\"Abieta-7,13-diene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66464", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O = scalarane-17alpha-19-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17144", "l": "glycine + oxaloacetate <=> glyoxylate + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047871", "l": "disulfoglucosamine-6-sulfatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24442", "l": "ADP + H(+) + 2 phosphate(in) => ATP + H2O + phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201457", "l": "BMP2 binds to the receptor complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8980691", "l": "RHOA GEFs activate RHOA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47003", "l": "H(+) + NADH + 2 NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> NAD(+) + 2 NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18577", "l": "3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine = 3-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.302", "l": "\"3-hydroxy-5-methyl-1-naphthoate 3-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39299", "l": "(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870465", "l": "RGGT binds the RAB-binding subunit (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102429", "l": "genistein-3-O-glucoside 1,6-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-13831"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38074", "l": "2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36123", "l": "gibberellin A20 + S-adenosyl-L-methionine = gibberellin A20 methyl ester + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649856", "l": "Oxidative damage to the AP site (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43234", "l": "H(+) + isatinate => H2O + isatin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852362", "l": "GTSE1 binds CDKN1A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948034", "l": "FGR binds LDL:LRP8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38024", "l": "gamma-tocotrienol => 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55546", "l": "H(+) + N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine => L-lysyl-[citrate synthase] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27957", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + presilphiperfolan-8beta-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-984671", "l": "Chromokinesins form dimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4332235", "l": "CBL binds TGFBR2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35285", "l": "(2E)-octadecenoyl-CoA => (9Z)-octadecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17385", "l": "H2O + hypotaurine + NAD(+) = H(+) + NADH + taurine"}, {"i": "EC:1.8.1.3", "l": "\"Hypotaurine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15260", "l": "D-threonine <=> acetaldehyde + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49520", "l": "2-oxoglutarate + N(6)-methyladenosine in mRNA + O2 = adenosine in mRNA + CO2 + formaldehyde + succinate"}, {"i": "EC:1.14.11.53", "l": "\"mRNA N(6)-methyladenine demethylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58907", "l": "8 (S)-methylmalonyl-CoA + 24 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH <=> C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52286", "l": "11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48078", "l": "4-(hydroxylamino)-N,N-dimethylaniline + an aldehyde => a primary alcohol + N,N-dimethyl-4-nitrosoaniline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047879", "l": "erythronolide synthase activity"}, {"i": "RHEA:23068", "l": "6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA = 6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+)"}, {"i": "EC:2.3.1.94", "l": "\"6-deoxyerythronolide-B synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693599", "l": "Association of Ku heterodimer with ends of DNA double-strand break (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41343", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 <=> 10R-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709852", "l": "MAVS:TOMM70 recruits HSP90:TBK1:IRF3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61286", "l": "(2R)-2-amino-2-carboxylatoethyl-disulfanyl-oxopropanoate + H2O2 + NH4(+) => H2O + L-cystine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161282", "l": "Elastic fibres bind associated proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30497", "l": "H(+) + H2O + N,N-dihydroxy-L-valine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-valine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19243", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17173", "l": "glutathionylspermidine + H2O = glutathione + spermidine"}, {"i": "EC:3.5.1.78", "l": "\"Glutathionylspermidine amidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604767", "l": "FLT3LG dimer:FLT3 dimer autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031704", "l": "apelin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42176", "l": "(9Z)-tetradecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-tetradecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24637", "l": "H2 + NAD(+) => H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.155"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43044", "l": "hexadecasphinganine + octadecanoyl-CoA = CoA + H(+) + N-octadecanoylhexadecasphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8954082", "l": "E2F6 binds the PRC1 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26527", "l": "a (3R)-3-hydroxyacyl-CoA => a (2E)-enoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21817", "l": "a D-alpha-amino acid + H2O + O2 => a 2-oxocarboxylate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2426569", "l": "Interaction of DAP12 and IREM2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34971", "l": "Fe(3+)(in) = Fe(3+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42946", "l": "5-methylcytidine(40) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine => cytidine(40) in tRNA precursor + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687088", "l": "PKA phosphorylates MAPKAPK5 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44646", "l": "a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+) => a 2'-deoxyribonucleoside 5'-triphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158137", "l": "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809680", "l": "MTMR12 binds MTM1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24710", "l": "2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose = L-glutamate + UDP-beta-L-threo-pentopyranos-4-ulose"}, {"i": "EC:2.6.1.87", "l": "\"UDP-4-amino-4-deoxy-L-arabinose aminotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45635", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-159194", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36328", "l": "ADP + dimethylallyl diphosphate => diphosphate + N(6)-(dimethylallyl)adenosine 5'-diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674550", "l": "p-Y-STAT1,3,5 dimer translocates from the cytosol to the nucleoplasm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199298", "l": "AKT phosphorylates CREB1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5159250", "l": "ATF7IP binds SETDB1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388814", "l": "Grb2 binds CD28 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60661", "l": "1,4-benzoquinone + H(+) + NADH => hydroquinone + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632038", "l": "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015483", "l": "long-chain fatty acid transporting porin activity"}, {"i": "TCDB:1.B.9.1.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12201", "l": "2'-deoxymugineate + 2-oxoglutarate + O2 => CO2 + mugineate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10885", "l": "(24R,24(1)R)-fucosterol epoxide => acetaldehyde + cholesta-5,24-dien-3beta-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52350", "l": "(24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+) => (24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17833", "l": "3-hydroxyanthranilate + S-adenosyl-L-methionine = 3-hydroxy-4-methylanthranilate + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.97", "l": "\"3-hydroxyanthranilate 4-C-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44708", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14370", "l": "2-phosphoglycolate + H2O => glycolate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24109", "l": "H2O + N-methyl-2-oxoglutaramate => 2-oxoglutarate + methylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18212", "l": "(2E)-geranyl diphosphate <=> (2S,4R)-bornyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953111", "l": "E2F6 binds TFDP1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63322", "l": "a glycerophospholipid(out) + ADP + H(+) + phosphate => a glycerophospholipid(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868236", "l": "BAR domain proteins recruit dynamin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21505", "l": "acetoin + aldehydo-D-ribose 5-phosphate => 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28906", "l": "D-alanine(in) + H(+)(in) <=> D-alanine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49992", "l": "H(+) + NADH + O2 + propane = H2O + NAD(+) + propan-2-ol"}, {"i": "EC:1.14.13.227", "l": "\"Propane 2-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45978", "l": "9alpha-hydroxy-3-oxochola-1,4-dien-22-oate + H2O + NAD(+) => 3-oxochola-1,4-dien-22-oate + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.27", "l": "\"Coagulation factor XIa\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26213", "l": "9alpha-copalyl diphosphate + H2O = aphidicolan-16beta-ol + diphosphate"}, {"i": "EC:4.2.3.42", "l": "\"Aphidicolan-16-beta-ol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865546", "l": "FOXP3 gene expression is stimulated by RUNX1:CBFB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624952", "l": "Assembly of the retrograde IFT train (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615945", "l": "RAN:GTP binds TNPO1/KPNB1 (transportin/importin beta) associated with the Nup107-160 complex and releases Nup107-160  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654167", "l": "Activated FGFR1 binds PLCG1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016169", "l": "bacteriochlorophyll c binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794336", "l": "NMDAR binds PSD-95 subfamily members (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166220", "l": "FA anion diffuses laterally to UCP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33468", "l": "ergosta-5,7,24(28)-trien-3beta-ol + H(+) + NADPH + O2 => ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56617", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene => 1,2,4-trichlorobenzene + chloride + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15118", "l": "3'-dephospho-CoA + ATP => 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612440", "l": "ERBB4s80 binds the MXD4 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66009", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + H2O2 + L-methionyl-[collagen] => [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693761", "l": "FA2H hydroxylates CERA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848087", "l": "STAP2 recruits STAT3 to PTK6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36816", "l": "dTDP-alpha-D-fucose => dTDP-alpha-D-fucofuranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389083", "l": "Autophosphorylation of PDGF alpha receptors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35550", "l": "cyclo(L-tyrosyl-L-tyrosyl) + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58814", "l": "AMP + diphosphate + H(+) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ATP + H2O + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11538", "l": "glycine betaine + H(+) + 2 H2O2 => choline + H2O + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8980691", "l": "RHOA GEFs activate RHOA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49536", "l": "2-amino-2-deoxy-D-gluconate = (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928627", "l": "EPHB phosphorylates TIAM1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682026", "l": "MRN bound to shortened telomeres activates ATM (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229343", "l": "AXIN is phosphorylated in the destruction complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63800", "l": "GDP-alpha-D-mannose = GDP-beta-L-gulose"}, {"i": "RHEA:63804", "l": "GDP-beta-L-gulose = GDP-beta-L-galactose"}, {"i": "EC:5.1.3.18", "l": "\"GDP-mannose 3,5-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61439", "l": "ADP + H2O <=> AMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65665", "l": "citrate(out) + 4 Na(+)(out) => citrate(in) + 4 Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007759", "l": "MSX2 binds RUNX2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55302", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-429157", "l": "ABCC4 accumulation of dense granule contents (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40566", "l": "dTDP-N-hydroxy-beta-L-evernosamine + H(+) + NADPH + O2 <=> dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45977", "l": "3-oxochola-1,4-dien-22-oate + H(+) + NADH + O2 => 9alpha-hydroxy-3-oxochola-1,4-dien-22-oate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061602", "l": "molybdenum cofactor cytidylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5334827", "l": "SUMO-CRABP2 binds atRA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199161", "l": "Fc gamma receptors interact with antigen-bound IgG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47258", "l": "6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964284", "l": "BTK in active Gq-BTK complex is activated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972967", "l": "POU5F1 (OCT4), SOX2, NANOG bind the EPHA1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612534", "l": "Expression of ID2 and ID4 is repressed by EGR2:NAB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55002", "l": "3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51948", "l": "(2S)-2-methylbutanenitrile + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2-methylbutanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-203979", "l": "Coat Assembly (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14626", "l": "[(1->4)-alpha-D-glucosyl](n) + [(1->6)-alpha-D-glucosyl](n+1) => [(1->4)-alpha-D-glucosyl](n+1) + [(1->6)-alpha-D-glucosyl](n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20653", "l": "23,24-dihydrocucurbitacin B + NAD(+) = cucurbitacin B + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53422", "l": "H(+) + roseoflavin + S-adenosyl-L-homocysteine => 8-demethyl-8-(methylamino)riboflavin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849055", "l": "PTK6 binds ARHGAP35 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168046", "l": "Collagen type XII degradation by MMP12 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295622", "l": "SPRY2 binds CBL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419269", "l": "TSFM binds TUFM displacing GDP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11557", "l": "(S)-carnitine + NAD(+) => 3-dehydrocarnitine + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026918", "l": "Lipoxygenase oxidises 17(S)-Hp-DHA to 7(S),17(S)-diHp-DHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49444", "l": "(2-aminobenzoyl)acetyl-CoA + H2O = (2-aminobenzoyl)acetate + CoA + H(+)"}, {"i": "EC:3.1.2.32", "l": "\"2-aminobenzoylacetyl-CoA thioesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11442", "l": "2,3,5,6-tetrachlorohydroquinone + H2O + NADP(+) => 2,3,5,6-tetrachlorophenol + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046899", "l": "nucleoside triphosphate adenylate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17458", "l": "[sulfur-carrier protein]-L-cysteine + L-cysteine => [sulfur-carrier protein]-S-sulfanyl-L-cysteine + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168809", "l": "SOCS binding to GHR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210805", "l": "Removal of miRNA passenger strand (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66188", "l": "3',5'-cyclic GMP(in) + ATP + H2O = 3',5'-cyclic GMP(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45063", "l": "H2O + N-(9Z-octadecenoyl) ethanolamine <=> (9Z)-octadecenoate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25622", "l": "geranylgeranyl diphosphate => tuberculosinyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381644", "l": "ER calcium channels open in response to activated PKA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65000", "l": "holo-[ACP] + octanoyl-AMP = AMP + H(+) + octanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061604", "l": "molybdopterin-synthase sulfurtransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47456", "l": "(3S)-hydroxy-(5Z-tetradecenoyl)-CoA + NAD(+) = 3-oxo-(5Z-tetradecenoyl)-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53471", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine + cholesterol <=> (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730842", "l": "PI3K associates with phosphorylated GAB2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351207", "l": "Spermine  => N-acetylated spermine (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30515", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = H(+) + S-methyl-5'-thioadenosine + thermospermine"}, {"i": "EC:2.5.1.79", "l": "\"Thermospermine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036046", "l": "Defective IDS does not hydrolyse Heparan sulfate chain(5) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865275", "l": "PDGF-BB clevage by Furin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694082", "l": "XK:KEL:Zn2+ cleaves EDN3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848818", "l": "PTK6 phosphorylates CBL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429815", "l": "Formation Of Bloc-1 Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246514", "l": "botC HC transports botC LC from target cell synaptic vesicle membrane to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685607", "l": "Sialic acid binds SIGLEC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164845", "l": "Suicidal integration leading to inverted circle formation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50739", "l": "a quinone + 2 H(+) + hydrogen sulfide + sulfite <=> a quinol + thiosulfate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106054", "l": "tRNA U34 thiol-transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60804", "l": "2-oxoglutarate + gibberellin A19 + O2 = CO2 + gibberellin A17 + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444691", "l": "Prokineticin receptors bind prokineticin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371582", "l": "HSBP1 binds HSF1 trimer (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357483", "l": "RAC1 binds PAK1-3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5662620", "l": "MT3 binds cadmium (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805022", "l": "USP2 binds the heterodimer of MDM2 and MDM4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14028", "l": "H(+) + H2O + sepiapterin <=> NH4(+) + xanthopterin-B2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45082", "l": "ADP + dapdiamide E + H(+) + phosphate => 3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033958", "l": "DNA-deoxyinosine glycosylase activity"}, {"i": "MetaCyc:3.2.2.15-RXN"}, {"i": "EC:3.2.2.15", "l": "\"DNA-deoxyinosine glycosylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50763", "l": "a quinone + H2O + sulfite <=> a quinol + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16753", "l": "Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADPH + O2 = 3,8-divinyl protochlorophyllide a + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3215406", "l": "PRMT5 binds WDR77 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12720", "l": "1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44680", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9615249", "l": "ARBs bind AGRT1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336184", "l": "GPR37L binds prosaposin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61381", "l": "2,4-dinitrophenyl-S-glutathione(in) + ATP + H2O => 2,4-dinitrophenyl-S-glutathione(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24301", "l": "2 cob(I)yrinate a,c diamide + FMN + 3 H(+) => 2 cob(II)yrinate a,c diamide + FMNH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030379", "l": "neurotensin receptor activity, non-G protein-coupled"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17269", "l": "macrocin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + tylosin"}, {"i": "EC:2.1.1.101", "l": "\"Macrocin O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20176", "l": "H(+) + NADH + O2 + tetradecanoyl-CoA <=> (11E)-tetradecenoyl-CoA + 2 H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49234", "l": "D-mannose 6-phosphate(in) + L-histidyl-[protein] => D-mannose(out) + N(pros)-phospho-L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-482772", "l": "Release of platelet cytosolic components (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195304", "l": "Association of beta-catenin with the destruction complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37704", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA => 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090584", "l": "protein-phosphocysteine-galactitol-phosphotransferase system transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17087", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + AH2 => 4-pyridoxate + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-372819", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32760", "l": "L-lysine => (3R)-3-methyl-D-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77077", "l": "Capping complex formation (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446634", "l": "IRAK4 is activated by autophosphorylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68611", "l": "Formation of ORC(1-5) complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66271", "l": "CoA + nonanoyl-AMP <=> AMP + H(+) + nonanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53280", "l": "D-threose = D-erythrulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193641", "l": "IKK-beta is recruited (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23356", "l": "ATP + L-seryl-[rhodopsin] = ADP + H(+) + O-phospho-L-seryl-[rhodopsin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60076", "l": "4beta-hydroxymethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2 = 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60332", "l": "L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14887", "l": "ADP-D-ribose + L-arginyl-[protein] => H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19705", "l": "CoA + hexadecanal + NAD(+) = H(+) + hexadecanoyl-CoA + NADH"}, {"i": "EC:1.2.1.42", "l": "\"Hexadecanal dehydrogenase (acylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33461", "l": "5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) => H(+) + NADPH + zymosterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14799", "l": "2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+) => 2-dehydro-3-deoxy-D-gluconate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013693", "l": "NICD4 binds RBPJ and MAML in the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12646", "l": "CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] => CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + S-2-(indol-3-yl)acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25026", "l": "H(+) + H2O + S-methyl-5'-thioadenosine => NH4(+) + S-methyl-5'-thioinosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951966", "l": "EP300 acetylates RUNX3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50668", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+)"}, {"i": "EC:2.4.1.344", "l": "\"Type 2 galactoside alpha-(1,2)-fucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661432", "l": "BIL binds ALB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54108", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + guaia-4,6-diene"}, {"i": "EC:4.2.3.179", "l": "\"Guaia-4,6-diene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788622", "l": "p-Y-STATs dimerize (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661419", "l": "ALB binds extracellular heme (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54495", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine <=> 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16371", "l": "H(+) + NADH + pyruvate => (R)-lactate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14331", "l": "3-phosphooxypyruvate + L-glutamate => 2-oxoglutarate + O-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11143", "l": "alpha-D-mannose 1-phosphate <=> D-mannose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141316", "l": "TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004993", "l": "G protein-coupled serotonin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11676", "l": "D-ribose + H2O + NADP(+) = D-ribonate + 2 H(+) + NADPH"}, {"i": "EC:1.1.1.115", "l": "\"Ribose 1-dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177920", "l": "Binding of GRB2 to GAB1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674385", "l": "p-T,Y MAPKs dimerize (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983307", "l": "IL15 binds IL15RA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48473", "l": "ganglioside GT1a + H2O => ganglioside GD1a + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5667052", "l": "ROPN1 binds RHOA:GTP:RHPN1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448603", "l": "IL33:IL1RL1 binds IL1RAP-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651992", "l": "PCNA-containing replication complex binds damaged dsDNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007646", "l": "CBX5 gene expression is inhibited by E2F6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001607", "l": "neuromedin U receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811472", "l": "IER3 recruits MAPKs to PP2A-B56-beta,gamma (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37854", "l": "13-deoxydaunorubicin + H(+) + NADPH + O2 <=> 13-dihydrodaunorubicin + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56587", "l": "1,2-epoxypropane + H2O <=> propane-1,2-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798489", "l": "S100A7 or S100A7A binds Zn2+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14127", "l": "1(F)-alpha-D-galactosylraffinose + sucrose => 2 raffinose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9706399", "l": "RHOBTB3 hydrolyzes ATP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120019", "l": "phosphatidylcholine transfer activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54687", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (-)-kolavenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13774", "l": "(S)-cheilanthifoline + O2 + reduced [NADPH--hemoprotein reductase] => (S)-stylopine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-202164", "l": "Translocation of PDK1 to Plasma membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65310", "l": "a 3-oxo-ultra-long-chain di-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP] => an ultra-long-chain di-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51023", "l": "2 [Fe(III)cytochrome c] + a primary alcohol <=> 2 [Fe(II)cytochrome c] + an aldehyde + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49416", "l": "ADP + alpha-D-ribose 1-phosphate = alpha-D-ribose 1,5-bisphosphate + AMP + H(+)"}, {"i": "EC:2.7.1.212", "l": "\"Alpha-D-ribose-1-phosphate 5-kinase (ADP)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24497", "l": "4-O-deacetylvindoline + acetyl-CoA => CoA + vindoline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864569", "l": "WWOX binds TFAP2C (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374337", "l": "Apelin receptor binds to apelin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0120300", "l": "peptide lactyltransferase activity"}, {"i": "RHEA:61996", "l": "L-lysyl-[protein] + lactoyl-CoA = CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5140741", "l": "WNT5A binds FZD and ROR receptors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40740", "l": "(20S)-ginsenoside Rb2 + 2 H2O => (20S)-ginsenoside C-Y + 2 D-glucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008479", "l": "queuine tRNA-ribosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27647", "l": "inosine + phosphate => alpha-D-ribose 1-phosphate + hypoxanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38448", "l": "4-O-(beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + H2O => 4-O-(beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47314", "l": "15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0043733", "l": "DNA-3-methylbase glycosylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10115", "l": "L-homocysteine + L-serine <=> H2O + L,L-cystathionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46369", "l": "2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (9Z,11E,13E)-octadecatrienoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047341", "l": "fucose-1-phosphate guanylyltransferase activity"}, {"i": "MetaCyc:2.7.7.30-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0016732", "l": "oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor"}, {"i": "EC:1.18.6.-", "l": "\"With dinitrogen as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22648", "l": "holo-[cytochrome c] = apo-[cytochrome c] + heme b"}, {"i": "EC:4.4.1.17", "l": "\"Holocytochrome-c synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59581", "l": "hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester => CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31986", "l": "abieta-7,13-dien-18-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> abieta-7,13-dien-18,18-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.25", "l": "\"L-arginine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31360", "l": "FMNH2 + nitrilotriacetate + O2 => ammoniodiacetate + FMN + glyoxylate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62260", "l": "2 hydrogencarbonate(out) + Mn(2+)(out) = 2 hydrogencarbonate(in) + Mn(2+)(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044025", "l": "histone kinase activity (H2B-S14 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357828", "l": "RIPK1 is cleaved by CASP8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429698", "l": "PRKD1,2,3 phosphorylates COL4A3BP-2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51920", "l": "a quinone + AH2 = A + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28191", "l": "2'-deoxyadenosine + H(+) + H2O => 2'-deoxyinosine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65964", "l": "ATP + H2O + taurocholate(out) = ADP + H(+) + phosphate + taurocholate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.101", "l": "\"2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase (NAD(P)H)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10688", "l": "H2O + streptomycin 6-phosphate = phosphate + streptomycin"}, {"i": "EC:3.1.3.39", "l": "\"Streptomycin-6-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63256", "l": "1-octadecanoyl-2-(15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13445", "l": "(R)-pantetheine + H2O = (R)-pantothenate + cysteamine"}, {"i": "EC:3.5.1.92", "l": "\"Pantetheine hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854303", "l": "TBC1D11 binds RAB6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63756", "l": "flavokermesate + UDP-alpha-D-glucose = flavokermesate 7-C-beta-D-glucoside + 2 H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16650", "l": "(S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-3'-hydroxy-N-methylcoclaurine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050268", "l": "coniferyl-alcohol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53431", "l": "a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] <=> a thymidine in DNA + S-methyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18336", "l": "ATP + oleandomycin <=> ADP + H(+) + oleandomycin 2'-O-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16249", "l": "alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate"}, {"i": "EC:5.1.3.15", "l": "\"Glucose-6-phosphate 1-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37796", "l": "2 H(+) + 2 NADPH + O2 => 2 H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44350", "l": "ADP + dapdiamide B + H(+) + phosphate => ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-921155", "l": "p-STAT5 dissociates from the receptor complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58850", "l": "(6E)-8-hydroxygeranial + H(+) + NADH => (6E)-8-hydroxygeraniol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139918", "l": "Phosphorylation of BIM by JNK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51650", "l": "(S)-2-amino-6-oxohexanoyl-[protein] + acetamide + H2O2 => H2O + N(6)-acetyl-L-lysyl-[protein] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25367", "l": "3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NADP(+) = H(+) + momilactone A + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805620", "l": "KAT6A and PML bind TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9005995", "l": "MECP2 binds the SIN3A co-repressor complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74740", "l": "Binding of SHC1 to insulin receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444100", "l": "PROT mediates L-proline uptake (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25183", "l": "CoA + H(+) + N-acetylputrescine => acetyl-CoA + putrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65876", "l": "5alpha-androst-1-ene-3,17-dione + H2O = 1-hydroxy-5alpha-androstan-3,17-dione"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047829", "l": "D-nopaline dehydrogenase activity"}, {"i": "RHEA:19637", "l": "D-nopaline + H2O + NADP(+) = 2-oxoglutarate + H(+) + L-arginine + NADPH"}, {"i": "EC:1.5.1.19", "l": "\"D-nopaline dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70481", "l": "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9658253", "l": "RAS:GTP binds PI3K (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605595", "l": "Hexosaminidase A cleaves GalNAc from GM2 to form GM3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950342", "l": "EBI3:CANX binds IL27 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805109", "l": "CDK2 phosphorylates TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624949", "l": "Assembly of the anterograde IFT train (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388828", "l": "PD-1 binds B7DC and B7H1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46609", "l": "ATP + L-threonyl-[protein] => ADP + H(+) + O-phospho-L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23750", "l": "diphosphate + pppGp(2'-5')A => ATP + GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65499", "l": "3beta-hydroxy-5beta-pregnane-20-one + H(+) + NADPH <=> 3beta,20alpha-dihydroxy-5beta-pregnane + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956659", "l": "ABL1 phosphorylates YAP1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811427", "l": "COPI vesicle uncoating at the ER (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12818", "l": "2,3-dihydrobiochanin A + NADP(+) => biochanin A + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15013", "l": "3alpha(S)-strictosidine + H2O = secologanin + tryptamine"}, {"i": "EC:4.3.3.2", "l": "\"Strictosidine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30701", "l": "3-oxopropanoate + L-glutamate => 2-oxoglutarate + beta-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39996", "l": "an N-acylethanolamine + H2O => a fatty acid + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451283", "l": "kainate receptor binds glutamate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21835", "l": "3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine <=> 3',5-dihydroxy-3,4',7-trimethoxyflavone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50542", "l": "prostaglandin C2 => prostaglandin A2"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0150100", "l": "RNA binding involved in posttranscriptional gene silencing"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53793", "l": "benzylthiol + O2 => benzothialdehyde + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174121", "l": "Association of Securin with Cdc20:APC/C complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53891", "l": "D-glucose 6-phosphate + TDP-alpha-D-glucose <=> alpha,alpha-trehalose 6-phosphate + H(+) + TDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22402", "l": "17beta-hydroxyandrostanone + H(+) + NADH => androstan-3alpha,17beta-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44370", "l": "Cr(3+) + 2 H(+) + 2 NADP(+) + superoxide => Cr(6+) + 2 NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16046", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose => a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209891", "l": "Dopamine is oxidised to noradrenaline (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654511", "l": "FGFRL1 dimer binds FGFs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32007", "l": "9alpha-copalyl diphosphate = diphosphate + isopimara-8(14),15-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50289", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 => (8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57448", "l": "ATP + D-tyrosine + tRNA(Tyr) = AMP + D-tyrosyl-tRNA(Tyr) + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57637", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + ML-236A carboxylate => holo-[2-methylbutanoate polyketide synthase] + mevinic carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211239", "l": "Association of DFF40 with chromatin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047919", "l": "GDP-mannose 6-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45293", "l": "2-glyceryl-prostaglandin G2 + AH2 => 2-glyceryl-prostaglandin H2 + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46855", "l": "5alpha-cholest-8-en-3-one + H(+) + NADPH <=> 5alpha-cholest-8-en-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61278", "l": "5-amino-2-oxopentanoate + H2O2 + NH4(+) => H2O + L-ornithine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801687", "l": "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166215", "l": "FA spontaneously flip-flops back to the matrix side (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32515", "l": "(4S,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O = (3S,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18088", "l": "coenzyme B + coenzyme M + methanophenazine <=> coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59405", "l": "L-homoserine => D-homoserine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47768", "l": "guanosine(2270) in 21S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(2270) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802170", "l": "TP53 stimulates PLK3 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799466", "l": "TP53I3 dimerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16664", "l": "fluoride + S-adenosyl-L-methionine <=> 5'-deoxy-5'-fluoroadenosine + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34584", "l": "2-oxoglutarate + O2 + pentalenolactone D => CO2 + H2O + pentalenolactone E + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63133", "l": "apo--[alkylcobalamin reductase] + glutathione + methylcob(III)alamin => cob(I)alamin--[alkylcobalamin reductase] + H(+) + S-methyl glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445064", "l": "Activation of Rac1 by VAV2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179291", "l": "UCHL5, USP15 deubiquitinate TGFBR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029268", "l": "Phosphorylation and activation of PLCG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874082", "l": "MET phosphorylates PTK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390930", "l": "5-HT2 receptor can bind serotonin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42279", "l": "2-methylbutanoyl-CoA + H(+) + malonyl-[ACP] <=> 4-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12560", "l": "hydroquinone + UDP-alpha-D-glucose = H(+) + hydroquinone O-beta-D-glucopyranoside + UDP"}, {"i": "EC:2.4.1.218", "l": "\"Hydroquinone glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36563", "l": "GDP-beta-L-colitose + NADP(+) = GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADPH"}, {"i": "RHEA:36567", "l": "GDP-beta-L-colitose + NAD(+) = GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADH"}, {"i": "EC:1.1.1.356", "l": "\"GDP-L-colitose synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030775", "l": "glucuronoxylan 4-O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20333", "l": "ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase]"}, {"i": "EC:2.7.11.27", "l": "\"[Acetyl-CoA carboxylase] kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72139", "l": "Formation of the active Spliceosomal C (B*) complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54881", "l": "(4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one => (3R)-3-isopropenyl-6-oxoheptanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390641", "l": "ADRA1A,B,D bind ADR,NAd (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654409", "l": "Activated FGFR3 binds FRS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25826", "l": "H2O2 + N-(3-aminopropyl)-4-aminobutanal + propane-1,3-diamine => H2O + O2 + spermine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951499", "l": "Loading of antigenic peptides on to class I MHC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483089", "l": "PE is converted to PS by PTDSS2 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047222", "l": "mannotetraose 2-alpha-N-acetylglucosaminyltransferase activity"}, {"i": "MetaCyc:2.4.1.138-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379387", "l": "COMT transfers Met to DA to form 3MT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392751", "l": "L1 linked to actin cytoskeleton by ankyrin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109858", "l": "MAP2K2 binds MAPK1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64733", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374899", "l": "Release of noradrenaline  at the synapse (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004143", "l": "diacylglycerol kinase activity"}, {"i": "RHEA:10272", "l": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)"}, {"i": "EC:2.7.1.107", "l": "\"Diacylglycerol kinase (ATP)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31383", "l": "(S)-2,3-epoxysqualene = lupeol"}, {"i": "EC:5.4.99.41", "l": "\"Lupeol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54494", "l": "1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine => 1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56178", "l": "8-carboxy-8-demethylriboflavin 5'-phosphate + AH2 + H(+) => 8-demethyl-8-formylriboflavin 5'-phosphate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6813740", "l": "GDE1 hydrolyzes GroPIns (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22058", "l": "H(+) + hexadecanal + NADH => hexadecan-1-ol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33538", "l": "H2O + lanosteryl ester <=> a carboxylate + H(+) + lanosterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015433", "l": "ABC-type peptide antigen transporter activity"}, {"i": "REACT:R-HSA-1236949", "l": "Translocation of antigenic peptides back to phagosomes via TAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16613", "l": "acetyl-CoA + an arylamine = an N-acetylarylamine + CoA"}, {"i": "EC:2.3.1.5", "l": "\"Arylamine N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814695", "l": "PERP binds desmosomes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048273", "l": "mitogen-activated protein kinase p38 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868118", "l": "MAPK12 phosphorylates PTPN3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58221", "l": "L-lysyl-[protein] + NAD(+) => H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20200", "l": "[heparosan-N-sulfate](n) <=> [heparan-N-sulfate](n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55112", "l": "4-methyl-3-oxopentanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-4-methylpentanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43767", "l": "ATP + chenodeoxycholate + CoA <=> AMP + chenodeoxycholoyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42183", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48698", "l": "H(+) + octanoate + octanoyl-3-(beta-D-galactosyl)-sn-glycerol => 1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10312", "l": "H(+) + NADH + O2 + terephthalate = (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)"}, {"i": "EC:1.14.12.15", "l": "\"Terephthalate 1,2-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63432", "l": "1,2,3-tri-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + a di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48907", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.2.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58992", "l": "(E)-cinnamaldehyde + H2O + O2 = (E)-cinnamate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936941", "l": "Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.39", "l": "\"Alkylglycerophosphoethanolamine phosphodiesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46689", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA + A => 3-oxo-cholest-4,24-dien-26-oyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050615", "l": "1,2-dihydrovomilenine reductase activity"}, {"i": "RHEA:12320", "l": "17-O-acetylnorajmaline + NADP(+) = 1,2-dihydrovomilenine + 2 H(+) + NADPH"}, {"i": "EC:1.3.1.73", "l": "\"1,2-dihydrovomilenine reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57545", "l": "(S)-beta-macrocarpene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + zealexin A1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24844", "l": "cyclobis-(1->3)-alpha-isomaltosyl + 2 H2O = 2 isomaltose"}, {"i": "EC:3.2.1.204", "l": "\"1,3-alpha-isomaltosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675194", "l": "Activated MAPK phosphorylates RAF1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28356", "l": "(2E)-decenoyl-CoA + FADH2 => decanoyl-CoA + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60096", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66786", "l": "6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(in) + L-histidyl-[protein] => N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950731", "l": "CRLF1:IL27 translocates to the extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013158", "l": "CDC42 GDIs block activation of CDC42 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34594", "l": "Co-precorrin-7 + S-adenosyl-L-methionine <=> Co-precorrin-8X + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867041", "l": "EGFR phosphorylates EPS15 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34715", "l": "15-methylhexadecasphing-4-enine + ATP = 15-methylhexadecasphing-4-enine 1-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37347", "l": "(R)-lactate + ATP + D-alanine = ADP + D-alanyl-(R)-lactate + phosphate"}, {"i": "EC:6.1.2.1", "l": "\"D-alanine--(R)-lactate ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66553", "l": "L-glutaminyl-[protein] + serotonin => 5-serotonyl-L-glutamyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16418", "l": "(S)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+) => H(+) + L-glutamate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3159253", "l": "MMAB transfers adenosyl group from ATP to cob(I)alamin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25432", "l": "beta-D-ribopyranose = beta-D-ribofuranose"}, {"i": "RHEA:25609", "l": "beta-D-allofuranose = beta-D-allopyranose"}, {"i": "EC:5.4.99.62", "l": "\"D-ribose pyranase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682826", "l": "LGI1 binds ADAM11 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36063", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + kunzeaol"}, {"i": "EC:4.2.3.143", "l": "\"Kunzeaol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634391", "l": "SHC1 binds phosphorylated ERBB2 homodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351208", "l": "Spermidine  => N-acetylated spermidine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395517", "l": "NADPH transfers electrons to FDXR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3782655", "l": "HDAC10 deacetylates histone (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20974", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11427", "l": "ATP + L-threonyl-[myosin heavy-chain] <=> ADP + H(+) + O-phospho-L-threonyl-[myosin heavy-chain]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49868", "l": "(+)-dehydrodiconiferyl acid + a quinone = (+)-dehydrodiconiferyl acid ketone + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23833", "l": "an N-acyl-D-mannosamine + ATP => ADP + an N-acyl-D-mannosamine 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18823", "l": "acetylcholine + CoA => acetyl-CoA + choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29709", "l": "1,6-anhydro-N-acetyl-beta-muramate(out) => 1,6-anhydro-N-acetyl-beta-muramate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3772441", "l": "sFRP binds WNT3A and inhibits WNT:FZD binding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47806", "l": "epothilone A + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => epothilone C + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34583", "l": "2-oxoglutarate + O2 + pentalenolactone D = CO2 + H2O + pentalenolactone E + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56466", "l": "1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => 1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38818", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23612", "l": "1,2-dihydro-alpha-santonin + NAD(+) = alpha-santonin + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050151", "l": "oleate hydratase activity"}, {"i": "MetaCyc:OLEATE-HYDRATASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-164423", "l": "PhosphoChREBP (Thr 666)  is exported to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18831", "l": "(R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH => 4-phospho-D-erythronate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45663", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396399", "l": "Fibrillins bind BMPs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8960973", "l": "RLBP1:11cRAL dissociates (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17752", "l": "A + H2O + quinoline <=> AH2 + quinolin-2(1H)-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59819", "l": "a long-chain fatty acyl-CoA + a sterol <=> a sterol ester + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.55"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49819", "l": "3 [Fe(III)cytochrome c] + H2O + hydrazine <=> 3 [Fe(II)cytochrome c] + 2 H(+) + NH4(+) + nitric oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72130", "l": "Formation of an intermediate Spliceosomal C (Bact) complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52763", "l": "(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O <=> (Z)-1-(glycyl-L-cystein-S-yl)-2-phenylacetohydroximate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165162", "l": "Phosphorylation of TSC2 by PKB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44111", "l": "H2O + heptanal + NAD(+) <=> 2 H(+) + heptanoate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173709", "l": "C7 binds C5b:C6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33120", "l": "(2E,6E)-farnesyl diphosphate => (+)-sativene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21263", "l": "[thioredoxin]-disulfide + H2O + L-methionine <=> [thioredoxin]-dithiol + L-methionine (R)-S-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31776", "l": "all-trans-retinyl hexadecanoate + H2O => 11-cis-retinol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13241", "l": "ATP + L-fucose = ADP + beta-L-fucose 1-phosphate + H(+)"}, {"i": "EC:2.7.1.52", "l": "\"Fucokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21371", "l": "H2O + O2 + urate <=> 5-hydroxyisourate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109702", "l": "PDPK1 phosphorylates AKT2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27828", "l": "L-homocysteine + succinate => hydrogen sulfide + O-succinyl-L-homoserine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11875", "l": "corticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 18-hydroxycorticosterone + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47597", "l": "an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate => an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy- beta-D-glucuronosyl)-N-acetyl- alpha-D-glucosaminyl phosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098619", "l": "selenocysteine-tRNA ligase activity"}, {"i": "REACT:R-HSA-2408526", "l": "tRNA(Sec) is serylated to Ser-tRNA(Sec) by SARS dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19628", "l": "L-threonine <=> acetaldehyde + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944262", "l": "Association of procollagen type X (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10163", "l": "L-iditol + NAD(+) <=> H(+) + keto-L-sorbose + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29125", "l": "H2O(out) + nitrite(out) + ubiquinone-8(in) => nitrate(out) + ubiquinol-8(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201639", "l": "Caspase-mediated cleavage of GAS2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018826", "l": "RHOT2 hydrolyzes GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60697", "l": "(R)-lavandulyl diphosphate + H2O => (R)-lavandulol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928631", "l": "GIT1 binds bPIX (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23749", "l": "ATP + GTP => diphosphate + pppGp(2'-5')A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428750", "l": "Gq activation by TP receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15912", "l": "2-oxoglutarate + O2 + taurine <=> aminoacetaldehyde + CO2 + H(+) + succinate + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39984", "l": "2 [Fe(II)-cytochrome b5] + a 1,2-saturated fatty acid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a 2-hydroxy fatty acid + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54155", "l": "a uridine in rRNA + S-adenosyl-L-methionine <=> a 2'-O-methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23574", "l": "3 CO2 + 4 CoA + phlorisovalerophenone => 3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295599", "l": "SPRY2 translocates to the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32101", "l": "DIMBOA beta-D-glucoside + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + TRIBOA beta-D-glucoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67014", "l": "a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate => a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14653", "l": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+)"}, {"i": "EC:3.1.4.17", "l": "\"3',5'-cyclic-nucleotide phosphodiesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32028", "l": "(2E,6E)-farnesyl diphosphate => (-)-alpha-cuprenene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247922", "l": "GGCT transforms gGluCys to OPRO (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4332235", "l": "CBL binds TGFBR2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61032", "l": "3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-methionine = 5-hydroxy-3,7,3',4'-tetramethoxyflavone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60942", "l": "(9Z)-16-hydroxyhexadec-9-enoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z)-hexadecenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-83788", "l": "Binding of TFIIIC to Type 2 promoter (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913675", "l": "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803527", "l": "ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62085", "l": "ADP + D-glucosamine => AMP + D-glucosamine 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803240", "l": "Homo- or heterodimerization of RAF downstream of mutant RAS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388468", "l": "AVP(20-28) binds AVPR1A,B (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30713", "l": "beta-myrcene + H2O => (S)-linalool"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198599", "l": "AKT phosphorylates MDM2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35565", "l": "(9Z)-hexadecenoate + ethanolamine => H2O + N-(9Z-hexadecenoyl) ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20051", "l": "1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide => 1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169398", "l": "ISGylation of host protein filamin B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.123", "l": "\"[Cytochrome c]-methionine S-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008732", "l": "L-allo-threonine aldolase activity"}, {"i": "EC:4.1.2.49", "l": "\"L-allo-threonine aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61553", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => gibberellin A12 aldehyde + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002173", "l": "low-affinity IgM receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132277", "l": "Complement factor H binds to surface-bound C3b (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37085", "l": "[sulfur carrier]-H + H(+) + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-homocysteine => [sulfur carrier]-SH + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57151", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.3"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0003823", "l": "antigen binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39854", "l": "2 a 1-acyl-sn-glycerol <=> a 1,2-diacyl-sn-glycerol + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-448678", "l": "CTSG cleaves CASP1(1-404) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65988", "l": "previtamin D3 = calciol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45376", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphinganine"}]}
{"type": "biolink:MolecularActivity", "ic": "80.661393760018115", "identifiers": [{"i": "GO:0015556", "l": "C4-dicarboxylate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54104", "l": "N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58834", "l": "4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O => 24-methylenecycloartanol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45892", "l": "an N-acylsphing-4-enine + CDP-ethanolamine = an N-acylsphing-4-enine 1-phosphoethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51567", "l": "cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> (25S)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50317", "l": "ethyl octadecanoate + H2O => ethanol + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112385", "l": "Addition of nucleotides leads to transcript elongation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48461", "l": "1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O => 2-octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38749", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-octadecenoyl) ethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043399", "l": "tRNA A64-2'-O-ribosylphosphate transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8870465", "l": "RGGT binds the RAB-binding subunit (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018719", "l": "6-aminohexanoate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66068", "l": "4-methyl-2-oxopentanoate + L-kynurenine = H2O + kynurenate + L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8858252", "l": "HDLBP binds HDL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874079", "l": "PTK2 binds activated MET (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38839", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2534096", "l": "METAP1/2 demethylates GNAT1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46627", "l": "a D-5-monosubstituted hydantoin <=> a L-5-monosubstituted hydantoin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19623", "l": "a nucleoside 3'-phosphate + H(+) => a nucleoside 2',3'-cyclic phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419152", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate + pyrophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8934446", "l": "Activated PKC phosphorylates SHC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114254", "l": "CYCS binds to APAF1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428750", "l": "Gq activation by TP receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480685", "l": "POU5F1 (OCT4), SOX2, NANOG bind the SOX2 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448632", "l": "IL34 dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24357", "l": "a 1-acyl-sn-glycero-3-phosphocholine => a 2-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65022", "l": "CoA + H(+) + N(2)-succinyl-L-ornithine => L-ornithine + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404142", "l": "atROL binds RBP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16874", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA => (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60420", "l": "H2O + triglucosyl-enterobactin = [N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]3 + H(+)"}, {"i": "EC:3.1.1.107", "l": "\"Apo-salmochelin esterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42856", "l": "1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O = 1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016422", "l": "mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42079", "l": "2-hydroxyglutarate + acetyl-CoA <=> 2-hydroxyglutaryl-CoA + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33025", "l": "CO2 + D-ribulose 5-phosphate + NADH => 6-phospho-D-gluconate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62758", "l": "4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70971", "l": "citrate <=> isocitrate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46683", "l": "2 [Fe(III)-cytochrome b5] + NADH <=> 2 [Fe(II)-cytochrome b5] + H(+) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008906", "l": "inosine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56392", "l": "[(3R)-hydroxybutanoate](n) + H2O = (3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42988", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = cembrene C + diphosphate"}, {"i": "EC:4.2.3.148", "l": "\"Cembrene C synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13777", "l": "ATP + D-ribose 5-phosphate + NH4(+) = 5-phospho-beta-D-ribosylamine + ADP + H(+) + phosphate"}, {"i": "EC:6.3.4.7", "l": "\"Ribose-5-phosphate--ammonia ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62516", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-galactosamine = H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55416", "l": "biochanin A + UDP-alpha-D-glucose = biochanin A 7-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.21", "l": "\"ADP-sugar diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54549", "l": "D-xylulose 1,5-bisphosphate + H2O => D-xylulose 5-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016404", "l": "15-hydroxyprostaglandin dehydrogenase (NAD+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782943", "l": "UV-DDB ubiquitinates XPC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54236", "l": "1,2-didecanoyl-sn-glycerol + CDP-choline = 1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42737", "l": "guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36784", "l": "L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629918", "l": "NEIL1 translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22518", "l": "ADP + H(+) + N-phosphotaurocyamine => ATP + taurocyamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19534", "l": "2 H(+) + 2 H2O + N(2)-succinyl-L-arginine => CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37519", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30217", "l": "a menaquinone + H2O + nitrous oxide => a menaquinol + 2 nitric oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25775", "l": "2-oxoglutarate + L-asparagine + O2 <=> (2S,3S)-3-hydroxyasparagine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50926", "l": "(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50306", "l": "21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + progesterone + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9029680", "l": "Caspase-7 translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665705", "l": "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3700992", "l": "TP53 stimulates MDM2 transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210277", "l": "Interaction of PECAM-1 and SHP-1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64367", "l": "prostaglandin G2 <=> (15S)-15-hydroperoxy-prostaglandin E2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72671", "l": "eIF5B:GTP is hydrolyzed and released (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15615", "l": "2 H(+) + NADH + sirohydrochlorin => NAD(+) + precorrin-2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34769", "l": "5-formyltetrahydrofolate + H(+) => 5,10-methenyltetrahydrofolate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61494", "l": "an N-(ultra-long-chain-acyl)-sphingoid base + CoA + H(+) => a sphingoid base + an ultra-long-chain fatty acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050001", "l": "D-glutaminase activity"}, {"i": "MetaCyc:D-GLUTAMINASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865994", "l": "GAB1 binds PTPN11 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62483", "l": "1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O <=> 2-glutaroyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912363", "l": "PRDM9 binds recombination hotspot motifs in DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54499", "l": "ent-copalyl diphosphate <=> diphosphate + ent-atiserene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33344", "l": "glycine + O2 => 2-iminoacetate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16997", "l": "3'-phosphoadenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol = 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-bisphosphate + H(+)"}, {"i": "EC:2.8.2.31", "l": "\"Petromyzonol sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37113", "l": "CoA + H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine => (15Z)-tetracosenoyl-CoA + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951676", "l": "RUNX3 binds TEADs and YAP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682983", "l": "ATM phosphorylates WHSC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228525", "l": "RANBP2 SUMOylates TOP2A with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483219", "l": "PC is exchanged with PI by PITPNB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14447", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+) => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48368", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189457", "l": "Mitochondrial intermembrane PRIN9 translocates to mitochondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013147", "l": "RAC1 GDIs block activation of RAC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12523", "l": "L-dopa <=> (E)-caffeate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949687", "l": "LETM1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050169", "l": "peptide-tryptophan 2,3-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64469", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NADP(+) => 4-methylsulfanyl-2-oxobutanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16055", "l": "H(+) + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112379", "l": "Recruitment of elongation factors to form elongation complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141139", "l": "Trimerization of TRAIL:TRAIL receptor complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052869", "l": "arachidonic acid omega-hydroxylase activity"}, {"i": "KEGG.REACTION:R07041"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14803", "l": "(2R)-3-phospho-glyceroyl phosphate + ADP => (2R)-3-phosphoglycerate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46261", "l": "2 [Fe(II)-cytochrome b5] + an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 H(+) + O2 => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033807", "l": "icosanoyl-CoA synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53438", "l": "19-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199456", "l": "PTEN dephosphorylates PIP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675206", "l": "PEA15 binds MAPK monomers and dimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55295", "l": "pseudouridine(54) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11058", "l": "4-aminophenol + CO2 + H2O + NADP(+) => 4-aminobenzoate + 2 H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63560", "l": "angiotensin I + H2O = angiotensin II + L-histidyl-L-leucine"}, {"i": "EC:3.4.15.1", "l": "\"Peptidyl-dipeptidase A\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35498", "l": "H2O + N-(4-aminobenzoyl)-L-glutamate <=> 4-aminobenzoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60284", "l": "N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37269", "l": "L-alanine + L-aspartate => H2O + L-alanyl-L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350651", "l": "Caspase-mediated cleavage of MASK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018756", "l": "RHOH binds GTP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210277", "l": "Interaction of PECAM-1 and SHP-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102784", "l": "lutein oxygenase activity"}, {"i": "MetaCyc:RXN-7884"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202692", "l": "PIP3 binds to RhoA and activates it (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23302", "l": "(2Z,6E)-farnesyl diphosphate + diphosphate => (2E)-geranyl diphosphate + isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694082", "l": "XK:KEL:Zn2+ cleaves EDN3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19073", "l": "ATP + L-seryl-[I-kappa-B protein] = ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein]"}, {"i": "EC:2.7.11.10", "l": "\"I-kappa-B kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866269", "l": "ARRB bind GPCRs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20030", "l": "10-deoxysarpagine + NADP(+) => H(+) + NADPH + vellosimine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614271", "l": "Autocleavage of ADGRG6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.25"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791016", "l": "SFTPB binds itself (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730904", "l": "Auto-ubiquitination of TRAF6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14167", "l": "CoA + H(+) + N-acetyl-L-aspartate => acetyl-CoA + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0030414", "l": "peptidase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159761", "l": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62336", "l": "AMP + ATP = adenosine 3'-diphosphate,5'-phosphate + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43684", "l": "ATP + L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphate = AMP + diphosphate + H(+) + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]"}, {"i": "EC:2.7.9.1", "l": "\"Pyruvate, phosphate dikinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976817", "l": "Formation of serum amyloid P decamer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56527", "l": "A + dihydro-heme d1 <=> AH2 + heme d1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46248", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (14Z)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15387", "l": "3-cyano-L-alanine + H2O => L-asparagine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35421", "l": "an anthocyanidin 3-O-sophoroside + 2 H(+) + UDP => an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689630", "l": "BAP1 binds BAP1-interacting complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44004", "l": "3-methyl fatty acid + ATP + CoA = a 3-methyl fatty acyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53439", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944263", "l": "Association of procollagen type II (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22443", "l": "UDP-alpha-D-galactose + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine + UMP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102460", "l": "kaempferol 3-gentiobioside 7-O-rhamnosyltransferase activity"}, {"i": "MetaCyc:RXN-14008"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53133", "l": "A + a 3-oxo-Delta(4)-steroid => a 3-oxo-Delta(1,4)-steroid + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465921", "l": "11cRDH oxidises 11cROL to 11cRAL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59388", "l": "a fatty acid ester + H2O = a fatty acid + an aliphatic alcohol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42047", "l": "GDP-beta-L-fucose + globoside GalGb4Cer (d18:1(4E)) <=> GDP + globoside Globo-H (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49670", "l": "deoxyviolaceinate + H2O + NAD(+) => H(+) + NADH + O2 + protodeoxyviolaceinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34029", "l": "(E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADPH => 3,3'-bipyridine-2,2',5,5',6,6'-hexol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034912", "l": "phthalate 3,4-cis-dihydrodiol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69068", "l": "RFC dissociates after sliding clamp formation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9652816", "l": "Constitutively active MAPK1 mutants are not dephosphorylated by DUSPs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64386", "l": "alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine + N-acetyl-D-6-sulfogalactosamine => H2O + N-acetyl-beta-D-6-sulfogalactosaminyl-(1->4)-alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168909", "l": "viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16647", "l": "CoA + H(+) + hexadecanoate => H2O + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17650", "l": "acetyl-[ACP] + malonate => acetate + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047236", "l": "methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53766", "l": "allocholoyl-CoA + lithocholate => allocholate + lithocholoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070007", "l": "glutamic-type endopeptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163310", "l": "TFAM binds to mitochondrial promoters (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036122", "l": "BMP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139941", "l": "Binding of IP3 to IP3 receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199062", "l": "KLRC1:KLRD1 heterodimer interacts with HLA-E (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51665", "l": "D-5-phenylhydantoin + H2O => H(+) + N-carbamoyl-D-phenylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14354", "l": "3-dehydro-L-gulonate 6-phosphate + H(+) => CO2 + L-xylulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11770", "l": "5-phospho-alpha-D-ribose 1-diphosphate + anthranilate => diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938121", "l": "SERPINB13 binds CTSK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33178", "l": "4-hydroxyphenylacetate(in) <=> 4-hydroxyphenylacetate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17116", "l": "H2O + L-serine-phosphoethanolamine <=> H(+) + L-serine + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004768", "l": "stearoyl-CoA 9-desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45200", "l": "(6S)-5,6,7,8-tetrahydrofolate + [methyl-Co(III) corrinoid Fe-S protein] = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + [Co(I) corrinoid Fe-S protein] + H(+)"}, {"i": "EC:2.1.1.258", "l": "\"5-methyltetrahydrofolate:corrinoid/iron-sulfur protein Co-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17083", "l": "H(+) + S-adenosyl-L-homocysteine + trans-isomethyleugenol => S-adenosyl-L-methionine + trans-isoeugenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004961", "l": "thromboxane A2 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61245", "l": "H2O + L-tryptophan + O2 => H2O2 + indole-3-pyruvate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42666", "l": "H(+) + L-arabinono-1,4-lactone + NADPH => L-arabinofuranose + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43819", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53556", "l": "(9R,10S)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9R,10S)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140761", "l": "sequestered tissue factor -> tissue factor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64406", "l": "carnosine(in) + H(+)(in) => carnosine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391939", "l": "TP receptor can bind thromboxane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32134", "l": "(2S)-ethylmalonyl-CoA + H(+) <=> butanoyl-CoA + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032800", "l": "Expression of NPPA (ANF) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622630", "l": "FOXO3,FOXO4,(FOXO1) bind BCL6 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70510", "l": "LDH tetramer oxidises LACT to PYR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31810", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-guaiene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12780", "l": "2-amino-4-hydroxypteridine + O2 <=> 2-amino-4,7-dihydroxypteridine + chemical entity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11330", "l": "diphosphate + neryl diphosphate => dimethylallyl diphosphate + isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349455", "l": "Phosphorylation of MDM4 by ATM (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24729", "l": "N-demethylindolmycin + S-adenosyl-L-methionine <=> H(+) + indolmycin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912366", "l": "MIR206 microRNA binds 3'UTR of NOTCH3 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55704", "l": "glycine + hydrogen sulfide + NAD(+) = ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide"}, {"i": "EC:2.4.2.59", "l": "\"Sulfide-dependent adenosine diphosphate thiazole synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18900", "l": "3,3',5'-triiodo-L-thyronine + A + H(+) + iodide <=> AH2 + L-thyroxine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209566", "l": "TRAF6 is auto-ubiquitinated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35864", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018745", "l": "epoxide hydrolase A activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62246", "l": "a cytidine-thymine dinucleotide in DNA => a cytidine(6-4)thymidine in DNA"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0004344", "l": "glucose dehydrogenase activity"}, {"i": "EC:1.1.99.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63879", "l": "2-oxoglutarate + 3(1)-hydroxy-L-isoleucine + O2 <=> (4S)-3(1),4-dihydroxy-L-isoleucine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "76.412572999466406", "identifiers": [{"i": "GO:0004620", "l": "phospholipase activity"}, {"i": "REACT:R-HSA-6786650", "l": "DDHD1,2 hydrolyse PA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51521", "l": "(S)-reticuline + S-adenosyl-L-methionine => (S)-tembetarine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.6.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55845", "l": "calcidiol + UDP-alpha-D-glucuronate => calcidiol 3-O-(beta-D-glucuronide) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1982066", "l": "Ligand-independent phosphorylation of overexpressed FGFR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39274", "l": "(3R)-hydroxy-(15Z)-tetracosenoyl-CoA <=> (2E,15Z)-tetracosadienoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37663", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP"}, {"i": "EC:2.4.1.312", "l": "\"Protein O-mannose beta-1,4-N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43221", "l": "guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65349", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA => 3-oxochol-4,6-dien-24-oyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39236", "l": "(3R)-hydroxytriacontanoyl-CoA => (2E)-triacontenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15651", "l": "CO2 + NH4(+) => carbamate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11415", "l": "6-hydroxymethyl-7,8-dihydropterin + ATP <=> (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372843", "l": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47084", "l": "4-methylsulfanyl-2-oxobutanoate + L-tyrosine = 3-(4-hydroxyphenyl)pyruvate + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29799", "l": "ATP + D-allose(out) + H2O = ADP + D-allose(in) + H(+) + phosphate"}, {"i": "EC:7.5.2.8", "l": "\"ABC-type D-allose transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70272", "l": "PGM:Mg2+ isomerise G6P to G1P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16446", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone => daidzein + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35591", "l": "H2 + n sulfur = H(+) + hydrogen sulfide + (n-1) sulfur"}, {"i": "EC:1.12.98.4", "l": "\"Sulfhydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928623", "l": "EPHBs bind NMDARs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871373", "l": "BMX phosphorylates RUFY1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601910", "l": "Complexed PIWIL2:2'-O-methyl-piRNA cleaves transposon RNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0022840", "l": "leak channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57919", "l": "ATP + L-aspartyl-tRNA(Asn) <=> 4-phosphooxy-L-aspartyl-tRNA(Asn) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14366", "l": "2 H(+) + H2O + N-carbamoyl-L-aspartate => CO2 + L-aspartate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000112", "l": "Endosomal TCII:Cbl translocates to lysosome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2002428", "l": "Removal of fibrillar collagen N-propeptides (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30712", "l": "(S)-linalool => beta-myrcene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2509831", "l": "ITPA hydrolyses XTP to XMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15050", "l": "GDP-alpha-D-glucose + H2O => D-glucose + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45477", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047705", "l": "bilirubin oxidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043897", "l": "glucan 1,4-alpha-maltohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34307", "l": "4-nitrocatechol + NADPH + O2 = 2-hydroxy-1,4-benzoquinone + H2O + NADP(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2130349", "l": "Generation of CLIP from lip10 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619449", "l": "PPM1F dephosphorylates p-T286-CaMKII (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803063", "l": "RNASEs bind bacterial LPS, PGN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45750", "l": "(2E)-hexenoyl-CoA => (3Z)-hexenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807826", "l": "LDHAL6B reduces PYR to LACT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390598", "l": "Myosin Binds ATP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39118", "l": "4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NAD(+) <=> 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38985", "l": "1-tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+) => 1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76456", "l": "O-atom dealkylation of dextromethorphan (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61747", "l": "steviolbioside + UDP-alpha-D-glucose <=> stevioside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211289", "l": "MAFA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16825", "l": "ATP + uridine = ADP + H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33879", "l": "2-deoxy-scyllo-inosamine + NADP(+) = 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH"}, {"i": "RHEA:33883", "l": "2-deoxy-scyllo-inosamine + NAD(+) = 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADH"}, {"i": "EC:1.1.1.329", "l": "\"2-deoxy-scyllo-inosamine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54941", "l": "(3Z)-decenoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxo-(5Z)-dodecenoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58667", "l": "(S)-2-hydroxyglutarate + a quinone <=> 2-oxoglutarate + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010177", "l": "2-(2'-methylthio)ethylmalate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9617595", "l": "SGTA binds mislocalized membrane protein (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9649733", "l": "mature p21 RAS binds GDP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60648", "l": "an N-(acyl)-sphingosylphosphoethanolamine = an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018770", "l": "6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050612", "l": "arsenate reductase (donor) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12167", "l": "3'-phosphoadenylyl sulfate + a phenol <=> a phenyl sulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805792", "l": "p-S291-PHF20 translocates to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15679", "l": "5-aminopentanoate + NH4(+) => 5-aminopentanamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23686", "l": "allocryptopine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983298", "l": "IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43520", "l": "2-carboxy-5-(dihydroxymethyl)furan + O2 = 2,5-dicarboxyfuran + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41838", "l": "3-oxooctanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + hexanoyl-[ACP] + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693540", "l": "MRN activates ATM (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22859", "l": "(7S)-salutaridinol + acetyl-CoA <=> (7S)-O-acetylsalutaridinol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57812", "l": "1-chloro-2-nitrobenzene + NADH + O2 = 3-chlorocatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37168", "l": "(2E,6E)-farnesol + NAD(+) => (2E,6E)-farnesal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35118", "l": "4-coumaroyl-CoA + H(+) + malonyl-CoA <=> (4-coumaroyl)acetyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20895", "l": "butanoyl-CoA + phosphate <=> butanoyl phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052876", "l": "methylamine dehydrogenase (amicyanin) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43427", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050098", "l": "methylguanidinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41381", "l": "H(+) + NADH + O2 + toluene => 4-methylphenol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15041", "l": "bis-D-fructose 2',1:2,1'-dianhydride + H2O = inulobiose"}, {"i": "EC:3.2.1.134", "l": "\"Difructose-anhydride synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53986", "l": "(11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59029", "l": "(Z)-24-ethylidenelophenol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32604", "l": "(6E)-8-hydroxygeraniol + NADP(+) => (6E)-8-oxogeraniol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27749", "l": "H(+) + L-cysteine <=> CO2 + cysteamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635843", "l": "GLI translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654511", "l": "FGFRL1 dimer binds FGFs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647978", "l": "pro-RAS proteins are farnesylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51150", "l": "an aldehyde + 2 H(+) + 2 reduced [azurin] => a primary alcohol + 2 oxidized [azurin]"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0097382", "l": "deoxynucleoside-diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13956", "l": "a D-aminoacyl-tRNA + H2O <=> a D-alpha-amino acid + H(+) + tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170674", "l": "Dissociation of the Gi alpha:G olf complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654163", "l": "Activated FGFR4 binds PLCG1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65708", "l": "alpha-D-mannose 1-phosphate + GDP-beta-L-galactose = beta-L-galactose 1-phosphate + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784959", "l": "BPHL hydrolyses VACV to ACV (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2176452", "l": "Degradation of ubiquitinated SMAD2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64853", "l": "benzoyl-CoA + octan-1-ol => CoA + octyl benzoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58712", "l": "NADH + O2 + rifampicin = H(+) + H2O + NAD(+) + rifampicin para-naphthoquinone carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3364026", "l": "SET1 complex trimethylates H3K4 at the MYC gene (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51617", "l": "ATP + formate + H(+) => CO2 + dATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-167419", "l": "The receptor:G-protein complex releases GDP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52237", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 => 3 A + Fe(2+) + 3 H2O + mycobilin b"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5688834", "l": "ATXN3 binds VCP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1067667", "l": "IL6 binds IL6R (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432533", "l": "PP1 binds to phosphorylated TIM (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15749", "l": "(S)-mandelate + A = AH2 + phenylglyoxylate"}, {"i": "EC:1.1.99.31", "l": "\"(S)-mandelate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34133", "l": "cannabinerolate + diphosphate => neryl diphosphate + olivetolate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66395", "l": "ATP + H2O + prostaglandin E1(in) <=> ADP + H(+) + phosphate + prostaglandin E1(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34862", "l": "3-oxocyclopentanecarbonitrile + 2 H2O <=> 3-oxocyclopentanecarboxylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46074", "l": "hexadecanoyl-CoA + NAD(+) => (2E)-hexadecenoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951499", "l": "Loading of antigenic peptides on to class I MHC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218847", "l": "PAK2 binds NCK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379982", "l": "glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-825631", "l": "Glucagon:GCGR mediates GTP-GDP exchange (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013108", "l": "GDIs block activation of RHOC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052846", "l": "inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity"}, {"i": "MetaCyc:RXN-10965"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58876", "l": "4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31064", "l": "3-methylbutanoyl-CoA + FAD + H(+) => 3-methyl-(2E)-butenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28253", "l": "acetyl-CoA + H(+) + malonyl-CoA <=> acetoacetyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47770", "l": "2'-O-methylguanosine(2270) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(2270) in 21S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64694", "l": "2-methylpropanal + H(+) + NADH => isobutanol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45239", "l": "(25R)-3beta-hydroxy-5-cholesten-26-al + H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta-hydroxy-5-cholestenoate + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2509831", "l": "ITPA hydrolyses XTP to XMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686625", "l": "LAIR1 binds collagen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613210", "l": "EGR1, EGR2 bind the RRAD promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938887", "l": "PML binds RUNX1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935864", "l": "miR-302b binds RUNX1 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177937", "l": "Phosphorylation of EGFR by SRC kinase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174058", "l": "Degradation of multiubiquitinated Cdh1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23134", "l": "7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite => 3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690740", "l": "CD22 binds B-cell receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.n2", "l": "\"Argonaute-2\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372819", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60964", "l": "(9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + UDP-alpha-D-glucose = (9Z)-17-hydroxyoctadec-9-enoate 17-O-sophoroside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11402", "l": "4'-O-demethylsordarin + GDP + H(+) => GDP-6-deoxy-alpha-D-altrose + sordaricin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53078", "l": "5-methylcytidine(34) in mitochondrial tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(34) in mitochondrial tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13509", "l": "H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine"}, {"i": "EC:2.7.7.23", "l": "\"UDP-N-acetylglucosamine diphosphorylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001852", "l": "complement component iC3b binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40696", "l": "1-hexadecanoylglycerone 3-phosphate + heptadecan-1-ol => 1-O-heptadecylglycerone 3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16181", "l": "3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine = 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.82", "l": "\"3-methylquercetin 7-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23897", "l": "5-dehydro-4-deoxy-D-glucuronate => 3-deoxy-D-glycero-2,5-hexodiulosonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38442", "l": "(9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25079", "l": "(2S)-2-isopropyl-3-oxosuccinate + H(+) => 4-methyl-2-oxopentanoate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15633", "l": "3,4-dihydroxyphenylacetate + O2 = 2-hydroxy-5-carboxymethylmuconate semialdehyde + H(+)"}, {"i": "EC:1.13.11.15", "l": "\"3,4-dihydroxyphenylacetate 2,3-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676133", "l": "CD74 binds MIF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36817", "l": "dTDP-alpha-D-fucofuranose => dTDP-alpha-D-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12603", "l": "2-oxoadipate + L-glutamate => 2-oxoglutarate + L-2-aminoadipate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49957", "l": "5,10-dihydrophenazine 1-carboxylate + O2 => H2O2 + phenazine-1-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50116", "l": "eicosanoyl-CoA + taurine = CoA + H(+) + N-eicosanoyl-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186778", "l": "SHP2 binds to the active receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11787", "l": "H2O + L-aspartate + NADP(+) <=> H(+) + NADPH + NH4(+) + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46866", "l": "a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018672", "l": "anthranilate 3-monooxygenase (deaminating) activity"}, {"i": "KEGG.REACTION:R00980"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015572", "l": "N-acetylglucosamine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691167", "l": "CUL1, SKP1, FBXL5 bind (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38141", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15095", "l": "3-(4-hydroxyphenyl)pyruvate + L-glutamate => 2-oxoglutarate + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56026", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) => H2O + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193997", "l": "CYP11B1 oxidises 11DCORT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51530", "l": "CO2 + guaiacol => 4-hydroxy-3-methoxybenzoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218812", "l": "FYN phosphorylates PAK2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605632", "l": "Both hexosaminidase A and B can cleave GalNAc from globoside (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14022", "l": "AH2 + ecdysone + O2 => 20-hydroxyecdysone + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61363", "l": "ATP + H2O + pheophorbide a(in) <=> ADP + H(+) + pheophorbide a(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189406", "l": "4 PBGs bind to form HMB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032502", "l": "Activated NTRK2 binds FYN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43765", "l": "ATP + chenodeoxycholate + CoA => AMP + chenodeoxycholoyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51462", "l": "(9Z)-octadecenoate + L-glutamate => H2O + N-(9Z-octadecenoyl)-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46875", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA <=> a 2-acyl-sn-glycero-3-phosphocholine + lipid IIB"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.4", "l": "\"Chymosin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54081", "l": "5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine => 5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635859", "l": "GLI:SUFU dissociates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42714", "l": "5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(54) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19191", "l": "[dihydrolipoyllysine-residue acetyltransferase]-(R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysine + CO2 => [dihydrolipoyllysine-residue acetyltransferase]-(R)-N(6)-lipoyl-L-lysine + H(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2984226", "l": "PLK1 phosphorylates NEK9 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15490", "l": "adenosine + H2O + 2 O2 => 9-riburonosyladenine + H(+) + 2 H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2197770", "l": "STAB1 (FEEL-1) binds ligands (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9681616", "l": "AP2 binds chlorpromazine (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15504", "l": "2 L-glutamate + NADP(+) <=> 2-oxoglutarate + H(+) + L-glutamine + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627078", "l": "XIAP binds CASP9 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2179413", "l": "Activated PKC-alpha  activate MMP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55569", "l": "4-hydoxytryptamine 4-phosphate + 2 S-adenosyl-L-methionine => 2 H(+) + psilocybin + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102839", "l": "1-18:2-2-16:2-monogalactosyldiacylglycerol desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111930", "l": "Adenylate cyclase produces cAMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240783", "l": "E2F1/2/3 stimulates EZH2 transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10509", "l": "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51862", "l": "8-geranylumbelliferone + diphosphate => (2E)-geranyl diphosphate + umbelliferone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44393", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA => 1-heptadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003977", "l": "UDP-N-acetylglucosamine diphosphorylase activity"}, {"i": "REACT:R-HSA-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62250", "l": "chloroacetate + 2 H(+) + NADPH => chloroacetaldehyde + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51724", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = adenosine 5'-tetraphosphate + ADP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30364", "l": "fumonisin B1 + 2 H2O => (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 H(+) + 2 tricarballylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36046", "l": "all-trans-8'-apo-beta-carotenal + O2 <=> 13-apo-beta-carotenone + 2,6-dimethyldeca-2,4,6,8-tetraenedial"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17678", "l": "2-(acetamidomethylene)-3-(hydroxymethyl)succinate + H(+) + 2 H2O => 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63397", "l": "A + Fe(II)-heme i + H2O => AH2 + Fe(II)-hydroxyheme i"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23673", "l": "a quinone + L-quinate => 3-dehydroquinate + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4088281", "l": "Endorepellin binds KDR (VEGFR2) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46166", "l": "a quinol + NADP(+) => a quinone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52171", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60004", "l": "(L-glutamyl)n+1-L-gamma-glutamyl-L-glutamyl-[protein] + H2O = (L-glutamyl)n-L-gamma-glutamyl-L-glutamyl-[protein] + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9607342", "l": "Expression of FABP6 regulated by NR1H2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201717", "l": "CSNK2-mediated phosphorylation of DVL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47106", "l": "5,6,7,8-tetrahydromethanopterin + L-serine => 5,10-methylenetetrahydromethanopterin + glycine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66520", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45924", "l": "9-decenoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(2-oxoundec-10-en-1-yl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0003747", "l": "translation release factor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32614", "l": "(6E)-8-hydroxygeranial + NADP(+) <=> (6E)-8-oxogeranial + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43619", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) <=> [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434097", "l": "viral dsRNA:TRL3:TICAM1 activates RIP1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671707", "l": "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.116", "l": "\"SpoIVB peptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213244", "l": "Loading of antigenic peptides (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23384", "l": "D-cellobiose = beta-D-glucosyl-(1->4)-D-mannopyranose"}, {"i": "EC:5.1.3.11", "l": "\"Cellobiose epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12186", "l": "(S)-acetoin + H(+) + NADH => (S,S)-butane-2,3-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9615249", "l": "ARBs bind AGRT1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862700", "l": "CMKLR1 binds Resolvin E1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49961", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + H(+) + O2 => 5,10-dihydrophenazine + CO2 + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-164696", "l": "Chico is phosphorylated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63574", "l": "L-arginine + neurotensin-(1-7) => H2O + neurotensin-(1-8)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55924", "l": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "RHEA:55928", "l": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] = fenbendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.73", "l": "\"Albendazole monooxygenase (sufoxide-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44629", "l": "L-dihydroanticapsin + NAD(+) => H(+) + L-anticapsin + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.3.18", "l": "\"Dimethylargininase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2467794", "l": "Resolution of sister chromatids (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380949", "l": "AMPK is dephosphorylated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9696267", "l": "RND3 binds GTP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088130", "l": "PLK1 binds FOXM1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30254", "l": "2 a ubiquinol + n H(+)(in) + O2 <=> 2 a ubiquinone + n H(+)(out) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41568", "l": "aclacinomycin T + dTDP-2-deoxy-beta-L-fucose = aclacinomycin S + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052917", "l": "dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase"}, {"i": "MetaCyc:RXN-5468"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56310", "l": "1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19955", "l": "an L-alpha-amino acid + pyruvate => a 2-oxocarboxylate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45568", "l": "[heparosan](n) = [acharan](n)"}, {"i": "EC:5.1.3.36", "l": "\"Heparosan-glucuronate 5-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23226", "l": "H(+) + O-beta-D-glucosyl-trans-zeatin + UDP => trans-zeatin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59789", "l": "H2O + NAD(+) + pseudopaline => (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6795290", "l": "TORC2 complex phosphorylates SGK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64640", "l": "H2O + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose = lactose + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39918", "l": "1-O-alkyl-sn-glycero-3-phosphate + H2O <=> 1-O-alkyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5096532", "l": "Defective GALNT12 does not transfer GalNAc to mucins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928578", "l": "EPH receptors autophosphorylate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204465", "l": "Basigin interacts with CD43 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61721", "l": "a D-guloside + NAD(+) => a 3-dehydro-D-guloside + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102684", "l": "L-phenylalanine N-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693125", "l": "RHOF binds effectors at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28689", "l": "orotate + ubiquinol-8 => (S)-dihydroorotate + ubiquinone-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64796", "l": "H2O + L-lysine + NADP(+) = (S)-2-amino-6-oxohexanoate + H(+) + NADPH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6795473", "l": "PDPK1 phosphorylates SGK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57896", "l": "2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2 = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202174", "l": "Activation of ZAP-70 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0004725", "l": "protein tyrosine phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57176", "l": "L-arginyl-[protein] + methylglyoxal = N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21213", "l": "H2O + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] => 4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174967", "l": "NAT2 acetylation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44047", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> 11,12-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166753", "l": "Conversion of C4 into C4a and C4b (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0016453", "l": "C-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13798", "l": "dolichyl phosphate + H2O => di-trans,poly-cis-dolichol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008389", "l": "RUNX2 binds HDAC6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40338", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66332", "l": "L-aspartate(out) = L-aspartate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.-.-", "l": "\"Acting on peptide bonds (peptidases)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37492", "l": "4-coumaroyl-CoA + S-adenosyl-L-methionine => CoA + H(+) + N-(4-coumaroyl)-L-homoserine lactone + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444572", "l": "Zinc is an agonist of GPR39 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102405", "l": "(+)-taxifolin 5'-hydroxylase activity"}, {"i": "RHEA:61116", "l": "(2R,3R)-dihydroquercetin + O2 + reduced [NADPH--hemoprotein reductase] = (2R,3R)-dihydromyricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "MetaCyc:RXN-13718"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420975", "l": "Ca impermeable AMPA receptor ligand binding (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030274", "l": "LIM domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42861", "l": "1,2-dioctanoyl-sn-glycero-3-phosphate + H2O => 1,2-dioctanoyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204500", "l": "CyP60 chaperones Basigin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4411383", "l": "NLK phosphorylates TCF/LEF (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65199", "l": "H2O + NAD(+) + S-(2-aminoethyl)-L-cysteine <=> H(+) + NADH + NH4(+) + S-(acetaldehyde)-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34766", "l": "(S,S)-tartrate(out) + succinate(in) <=> (S,S)-tartrate(in) + succinate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-182988", "l": "Sprouty lures CBL away from EGFR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41240", "l": "N-acyl (9Z,12Z)-octadecadienoate octadecasphin-4E-enine + O2 => N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26157", "l": "D-mannose + NADP(+) => D-glucosone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41762", "l": "CMP + ganglioside GD3 (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM3 (d18:1(4E))"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-879562", "l": "SLCO2B1 has a narrow substrate specificity (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110463", "l": "Increased PIP3 levels recruit DAkt1 to the membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8942302", "l": "MMP13 cleaves OPTC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445064", "l": "Activation of Rac1 by VAV2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805811", "l": "Release of SEPT4 from mitochondria (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5357483", "l": "RAC1 binds PAK1-3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002055", "l": "adenine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799431", "l": "TP53 binds HIPK1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60078", "l": "4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H2O + NAD(+) => 4beta-hydroxymethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.1.3", "l": "\"NAD(P)(+) transhydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1236970", "l": "Proteasomal clevage of exogenous antigen (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31057", "l": "estrone + H(+) + sulfate => estrone 3-sulfate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18856", "l": "NAD(+) + tartrate <=> 2-hydroxy-3-oxosuccinate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32938", "l": "a cardiolipin + H2O <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62804", "l": "2 7-demethylsiderin + NADPH + O2 = desertorin A + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12307", "l": "(S)-2-amino-6-oxohexanoate + H2O + NADP(+) <=> 2 H(+) + L-2-aminoadipate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41269", "l": "(15Z)-tetracosenoate + sphing-4-enine => H2O + N-(15Z-tetracosenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18371", "l": "dihydroxyacetone phosphate + H2O2 => O2 + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432010", "l": "Aquaporin-1 passively transports water into cell (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035991", "l": "nitric oxide sensor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9613497", "l": "Unwinding DNA for the nascent transcript (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005131", "l": "growth hormone receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19502", "l": "4-guanidinobutanoate + H2O => 4-aminobutanoate + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810937", "l": "Lamellar bodies bind the early cornified envelope (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1861789", "l": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018594", "l": "tert-butanol 2-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698174", "l": "FLT3 mutants recruit PIK3CA through PIK3R1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000907", "l": "sulfonate dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-164840", "l": "ADP and Pi bind to ATPase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-169895", "l": "Crk's SH3 domain engages C3G (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10880", "l": "7-methylxanthosine + H2O = 7-methylxanthine + D-ribose + H(+)"}, {"i": "EC:3.2.2.25", "l": "\"N-methyl nucleosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55086", "l": "(3R)-3-hydroxypentanoate + CoA + H(+) => (3R)-3-hydroxypentanoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29077", "l": "CO2(out) + H(+)(out) + ubiquinol-8 => formate(out) + 2 H(+)(in) + ubiquinone-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49926", "l": "(R)-carnitine(in) + O-acyl-(R)-carnitine(out) => (R)-carnitine(out) + O-acyl-(R)-carnitine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9641111", "l": "Parkin transfers Ub to misfolded proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951977", "l": "Acetylated RUNX3 binds to BRD2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23736", "l": "5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)"}, {"i": "EC:3.5.2.17", "l": "\"Hydroxyisourate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37334", "l": "H2O + L-methionyl-L-alanine <=> L-alanine + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13141", "l": "2-methylpropanoyl-CoA = butanoyl-CoA"}, {"i": "EC:5.4.99.13", "l": "\"Isobutyryl-CoA mutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177937", "l": "Phosphorylation of EGFR by SRC kinase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58711", "l": "rifampicin ortho-naphthoquinone carboxamide <=> rifampicin para-naphthoquinone carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59248", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + (E)-4-coumaroyl-CoA = (E)-4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204813", "l": "Interaction of Tie2 and Grb14 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879222", "l": "MDP:NLRP1 binds ATP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60034", "l": "8-oxo-GDP + H(+) + phosphate => 8-oxo-GTP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432909", "l": "Interaction of Plectin with Integrin beta 4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60424", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + valerianol"}, {"i": "EC:4.2.3.204", "l": "\"Valerianol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33713", "l": "2 H(+) + maleylacetate + sulfite => 4-sulfomuconolactone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678749", "l": "Defective ABCB4 does not transport PC from plasma membrane to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218806", "l": "FYN autophosphorylates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21248", "l": "a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)"}, {"i": "EC:2.7.7.48", "l": "\"RNA-directed RNA polymerase\""}, {"i": "EC:2.7.7.6", "l": "\"DNA-directed RNA polymerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033898", "l": "Bacillus subtilis ribonuclease activity"}, {"i": "MetaCyc:3.1.27.2-RXN"}, {"i": "EC:4.6.1.22", "l": "\"Bacillus subtilis ribonuclease\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975594", "l": "PLB1 hydrolyses RPALM to atROL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11580", "l": "a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)"}, {"i": "EC:2.7.8.11", "l": "\"CDP-diacylglycerol--inositol 3-phosphatidyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102742", "l": "R(+)-3,4-dihydroxyphenyllactate:NADP+ oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57567", "l": "(+)-cis-trans-nepetalactol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-deoxyloganetic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18383", "l": "dihydroxyacetone phosphate + pyruvate => dihydroxyacetone + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847537", "l": "RAB43:GTP binds USP8NL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16338", "l": "a 3'-unsubstituted flavone + O2 + reduced [NADPH--hemoprotein reductase] => a 3'-hydroxyflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917696", "l": "Cargo Sequestration (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46300", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 2-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389083", "l": "Autophosphorylation of PDGF alpha receptors (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20840", "l": "H(+) + L-histidine = CO2 + histamine"}, {"i": "EC:4.1.1.22", "l": "\"Histidine decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14462", "l": "(25S)-5beta-spirostan-3beta-ol + UDP-alpha-D-glucose => (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31640", "l": "mycinamicin III + S-adenosyl-L-methionine => H(+) + mycinamicin IV + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49011", "l": "aurachin C + H(+) + NADPH + O2 <=> aurachin C epoxide + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59663", "l": "D-cellotetraose + O2 <=> D-cellotetraono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42781", "l": "adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000399", "l": "RANBP2 SUMOylates SP100 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19156", "l": "apigenin 7-O-beta-D-glucoside + UDP-alpha-D-apiose <=> 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57643", "l": "14 H(+) + holo-[equisetin nonaketide synthase] + 8 malonyl-CoA + 8 NADPH + 2 S-adenosyl-L-methionine <=> (3-{(1R,2S,6S,8R)-2,8-dimethyl-3-[(E)-prop-1-enyl]-4,5-didehydrodecalin-2-yl}-3-oxopropanoyl)-[equisetin nonaketide synthase] + 8 CO2 + 8 CoA + 6 H2O + 8 NADP(+) + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17482", "l": "2 cob(I)alamin + H(+) + NAD(+) => 2 cob(II)alamin + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209925", "l": "DIT and MIT combine to form triiodothyronine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37118", "l": "sphing-4-enine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981832", "l": "NMUR2 binds neuromedin-S (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357831", "l": "CYLD is phosphorylated by IKK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199154", "l": "CD200 binds to CD200R (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22127", "l": "17-O-acetylajmaline + H2O <=> acetate + ajmaline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48499", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + UDP-alpha-D-galactose <=> 1-(9Z-octadecenoyl)-2-hexadecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42126", "l": "3alpha-hydroxy-5alpha-androstan-17-one + H(+) + NADH => 5alpha-androstane-3alpha,17beta-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47873", "l": "ganglioside GM1 + H2O => ganglioside GA1 + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692755", "l": "CDK1 phosphorylates MAPK6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56109", "l": "genistein + O2 + reduced [NADPH--hemoprotein reductase] => 2'-hydroxygenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43621", "l": "L-serine + NADP(+) => aminoacetaldehyde + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381612", "l": "GLP1R binds GLP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013158", "l": "CDC42 GDIs block activation of CDC42 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40140", "l": "(9Z)-octadecenoyl-CoA + H2O => (9Z)-octadecenoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23015", "l": "a fatty acid + S-adenosyl-L-methionine <=> a fatty acid methyl ester + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48819", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 <=> 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54888", "l": "ATP + CoA + OPC-8 = AMP + diphosphate + OPC-8-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11472", "l": "an N-methyl-L-amino acid + H2O + O2 = an L-alpha-amino acid + formaldehyde + H2O2"}, {"i": "EC:1.5.3.2", "l": "\"N-methyl-L-amino-acid oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675198", "l": "Activated MAPKs phosphorylate BRAF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12519", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-(R)-germacrene A + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201669", "l": "Beta-catenin translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58392", "l": "4-amino-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865182", "l": "OTUD7A hydrolyses K11diUb (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "80.661393760018115", "identifiers": [{"i": "GO:0019203", "l": "carbohydrate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49749", "l": "2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate => CO2 + 2 H2O + NADP(+) + proviolacein"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58234", "l": "H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein] => L-seryl-[protein] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29859", "l": "5'-deoxyadenosine + H2O = 5-deoxy-D-ribose + adenine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008387", "l": "steroid 7-alpha-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55239", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H2O <=> (9Z)-octadecenoate + 1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.2", "l": "\"Beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55550", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607746", "l": "PKC-delta is activated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38708", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026502", "l": "NTF3-bound NTRK2 dimers trans-autophosphorylate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70510", "l": "LDH tetramer oxidises LACT to PYR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21321", "l": "A + D-sorbitol => AH2 + keto-L-sorbose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56578", "l": "globoside Gb4Cer + H(+) + UDP => globoside Gb3Cer + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17502", "l": "H2O + polyneuridine aldehyde => 16-epivellosimine + CO2 + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57501", "l": "3-hydroxybutane-1,2,3-tricarboxylate => 2-methyl-cis-aconitate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947647", "l": "GHSR is a receptor for ghrelin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21616", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)"}, {"i": "EC:2.4.99.4", "l": "\"Beta-galactoside alpha-2,3-sialyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665703", "l": "ERBB2 TMD/JMD mutants bind pertuzumab (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781840", "l": "ERCC6 binds stalled RNA Pol II (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37368", "l": "CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine => 2,3-bis-O-phytanyl-sn-glycero-3-phospho-L-serine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59111", "l": "chenodeoxycholate + octyl beta-D-glucose <=> beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070095", "l": "fructose-6-phosphate binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004367", "l": "glycerol-3-phosphate dehydrogenase [NAD+] activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694433", "l": "MIA2 binds PREB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12117", "l": "A + H2 => AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17734", "l": "acetylenedicarboxylate + H(+) + H2O => CO2 + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983709", "l": "LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10796", "l": "albendazole + H(+) + NADPH + O2 = albendazole S-oxide + H2O + NADP(+)"}, {"i": "EC:1.14.13.32", "l": "\"Albendazole monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "62.809906813740142", "identifiers": [{"i": "GO:0043167", "l": "ion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75080", "l": "Formation of AT-AC A complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16525", "l": "2-dehydro-3-deoxy-D-galactonate + ATP = 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018823", "l": "cyclohexa-1,5-dienecarbonyl-CoA hydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592240", "l": "Formation of NRF2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30673", "l": "2 N-acetyl-D-glucosamine => H2O + N,N'-diacetylchitobiose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33537", "l": "a carboxylate + H(+) + lanosterol => H2O + lanosteryl ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66095", "l": "3-phenylpyruvate + L-kynurenine <=> H2O + kynurenate + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58320", "l": "25-substituted-cholesterol + a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine = 25-substituted-cholesteryl beta-D-glucoside + an N-acylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420591", "l": "Nectin-2:Nectin 3 trans heterodimer interaction (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10148", "l": "blasticidin S + H(+) + H2O = deaminohydroxyblasticidin S + NH4(+)"}, {"i": "EC:3.5.4.23", "l": "\"Blasticidin-S deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2586559", "l": "Leptin Binds Leptin Receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24397", "l": "scytalone => 1,3,8-trihydroxynaphthalene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170810", "l": "nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54326", "l": "a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin] => a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 8 oxidized 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237119", "l": "Acireductone is oxidized to MOB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17559", "l": "CoA + N-malonylanthranilate => anthranilate + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45352", "l": "9,10-epoxyoctadecanoate + H2O = 9,10-dihydroxyoctadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009309", "l": "RUNX2 binds STUB1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44212", "l": "3-hydroxytetradecanoate + ATP + CoA = 3-hydroxytetradecanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37558", "l": "D-kanosamine 6-phosphate + H2O <=> kanosamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58075", "l": "a 4,5-didehydrojasmonate + H(+) + NADPH <=> a jasmonate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.2.1.-", "l": "\"Cis-trans isomerases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62284", "l": "2 ATP + L-proline + L-tryptophan + NADPH = (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + 2 AMP + 2 diphosphate + H(+) + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209792", "l": "N-acetylation of serotonin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429663", "l": "SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26448", "l": "H(+) + malonyl-CoA + NADPH => 3-oxopropanoate + CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58847", "l": "(6E)-8-hydroxygeranial + NAD(+) <=> (6E)-8-oxogeranial + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44951", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + H2O <=> 1-O-alkyl-2-acyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693598", "l": "ATM phosphorylates NBN (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265456", "l": "NPC1L1 binds ezetimibe (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051749", "l": "indole acetic acid carboxyl methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446372", "l": "Association of  PARVA with TESK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51214", "l": "12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH => (5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72139", "l": "Formation of the active Spliceosomal C (B*) complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64403", "l": "an L-amino acid tripeptide(out) + H(+)(out) <=> an L-amino acid tripeptide(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18181", "l": "acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H(+)"}, {"i": "EC:2.3.3.9", "l": "\"Malate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30319", "l": "H(+) + NADH + O2 + theobromine = 7-methylxanthine + formaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174445", "l": "RPA binds to the Flap on the C-strand (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061730", "l": "C-rich strand telomeric DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28108", "l": "H(+) + keto-D-tagatose 6-phosphate + NADH => galactitol 1-phosphate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11537", "l": "choline + H2O + 2 O2 => glycine betaine + H(+) + 2 H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944229", "l": "Association of procollagen type IX (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0120296", "l": "peptide dopaminyltransferase activity"}, {"i": "RHEA:66556", "l": "dopamine + L-glutaminyl-[protein] = 5-dopaminyl-L-glutamyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444208", "l": "MLNR (GPR38) is a receptor for motilin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015100", "l": "vanadium ion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237119", "l": "Acireductone is oxidized to MOB (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362416", "l": "Frataxin binds iron (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47924", "l": "2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate = (S)-3-sulfolactaldehyde + pyruvate"}, {"i": "EC:4.1.2.58", "l": "\"2-dehydro-3,6-dideoxy-6-sulfogluconate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55673", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine => 4-O-([2-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28432", "l": "D-allulose 6-phosphate => D-allose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38108", "l": "2-dehydro-3-deoxy-L-galactonate => L-glyceraldehyde + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987120", "l": "JAK1 binds IFNLR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13308", "l": "E-sinapate + UDP-alpha-D-glucose <=> 1-O-(trans-sinapoyl)-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665761", "l": "FMNL3 binds RHOC:GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52861", "l": "a short-chain fatty acid + ATP + CoA => a short chain fatty acyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005113", "l": "patched binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034891", "l": "endosulfan diol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3899291", "l": "SUMOylation of EP300 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52553", "l": "3-dehydro-L-erythronate + ATP => 3-dehydro-4-O-phospho-L-erythronate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2213210", "l": "Collagen IX is cross-linked to the surface of collagen type II fibrils (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28473", "l": "pyridoxine(in) <=> pyridoxine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009037", "l": "tyrosine-based site-specific recombinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66780", "l": "6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine + H2O = N-acetyl-D-glucosamine + N-acetyl-D-muramate 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41794", "l": "CoA + malonyl-[ACP] => holo-[ACP] + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005335", "l": "serotonin:sodium symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55484", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] = ent-cassa-12,15-dien-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875183", "l": "CBL monoubiquitinates activated MET (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50471", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 27 H(+) + 9 malonyl-CoA + 18 NADPH <=> 19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 9 H2O + 18 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14378", "l": "(3R)-3-hydroxy-L-aspartate => glycine + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050078", "l": "malonate CoA-transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684043", "l": "Defective ABCD1 does not transfer LCFAs from cytosol to peroxisomal matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694421", "l": "PP6 dephosphorylates SEC24 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20334", "l": "ATP + L-seryl-[acetyl-CoA carboxylase] => ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671855", "l": "Phosphorylated LEPR Binds STAT5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25764", "l": "(2R,3S)-3-methylmalate + NAD(+) => 3-carboxy-2-oxobutanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41542", "l": "8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine => 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58394", "l": "4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 4-amino-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22293", "l": "benzoyl-CoA + 3 H(+) + 3 malonyl-CoA => biphenyl-3,5-diol + 4 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189439", "l": "ALAD condenses 2 dALAs to form PBG (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43453", "l": "2 H(+) + hexanoyl-CoA + 2 malonyl-CoA => 4-hydroxy-6-pentylpyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.19"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61465", "l": "a cytidine in mRNA + S-adenosyl-L-methionine => a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225894", "l": "Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-167415", "l": "G-protein alpha subunit is inactivated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417896", "l": "P2Y6 receptor can bind to UDP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35668", "l": "a triacylglycerol + H2O => a 1,2-diacylglycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62141", "l": "dTMP + GTP => dTDP + GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686524", "l": "PP6-PPP6R3 dephosphorylates TERF2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50429", "l": "methanethiol + S-adenosyl-L-methionine => dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58461", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine => a monoacyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936655", "l": "sulfite results from reduction of APS (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28783", "l": "H2O + L-cysteinylglycine = glycine + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209823", "l": "Tyrosine is hydroxylated to dopa (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39412", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA => (2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33097", "l": "futalosine => chorismate + inosine + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31817", "l": "(+)-beta-caryophyllene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26181", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O => 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682011", "l": "LC3 binds ATG7 dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944266", "l": "Association of procollagen type XI (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58067", "l": "O2 + reduced [NADPH--hemoprotein reductase] + xanthotoxin <=> 5-hydroxyxanthotoxin + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23489", "l": "1,4-benzoquinone + H(+) + NADPH => hydroquinone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52985", "l": "7-oxoheptanoyl-[ACP] + H2O + oxidized [flavodoxin] => 6-carboxyhexanoyl-[ACP] + reduced [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46916", "l": "H2O + juvenile hormone I = H(+) + juvenile hormone I carboxylate + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374896", "l": "Uptake of Noradrenaline (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001571", "l": "non-tyrosine kinase fibroblast growth factor receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654404", "l": "Activated FGFR2 binds SHC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444572", "l": "Zinc is an agonist of GPR39 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031216", "l": "neopullulanase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48811", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420975", "l": "Ca impermeable AMPA receptor ligand binding (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004400", "l": "histidinol-phosphate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13136", "l": "CTP + di-trans,poly-cis-dolichol <=> CDP + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9699574", "l": "FOXO3-dependent BCL2L11 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26453", "l": "CoA + NADP(+) + succinate semialdehyde <=> H(+) + NADPH + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174367", "l": "GCL ligates L-Glu to L-Cys (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672969", "l": "Phosphorylation of RAF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357828", "l": "RIPK1 is cleaved by CASP8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8876789", "l": "CARNMT1 methylates CARN to Anserine (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21457", "l": "(S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37179", "l": "(9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate = (6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2197691", "l": "WIP binds WASP,N-WASP, activating them (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3159253", "l": "MMAB transfers adenosyl group from ATP to cob(I)alamin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50993", "l": "thromboxane B2(out) => thromboxane B2(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712201", "l": "GNAL exchanges GDP for GTP in odorant:Olfactory Receptor:GNAL:GDP:GNB1:GNG13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53743", "l": "[Rab1 protein]-O(4)-(5'-adenylyl)-L-tyrosine + H2O <=> [Rab1 protein]-L-tyrosine + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902118", "l": "calcidiol binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13432", "l": "2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) <=> 4-CDP-2-C-methyl-D-erythritol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047503", "l": "(-)-borneol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052894", "l": "norspermine:oxygen oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0016312", "l": "inositol bisphosphate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63360", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + O2 = (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-oxazole-[protein] + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10975", "l": "D-hexose + H(+) + phosphoramidate <=> alpha-D-hexose 1-phosphate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-981713", "l": "C4b binds to cell surface (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40778", "l": "2-amino-2-phenylacetonitrile + H(+) + 2 H2O <=> D-alpha-phenylglycine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49284", "l": "8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP = CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate"}, {"i": "EC:2.7.7.90", "l": "\"8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1470009", "l": "Phosphorylation of STATs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40483", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51926", "l": "A + beta-dihydromenaquinone-9 => AH2 + menaquinone-9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362551", "l": "Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21723", "l": "formamide <=> H2O + hydrogen cyanide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400204", "l": "PPARA binds RXRA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10745", "l": "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) => 3,4-dihydroxybenzoate + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033515", "l": "TYSND1 cleaves ACOX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41183", "l": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-sn-glycero-3-phosphocholine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626220", "l": "C2CD3 binds the mother centriole (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69173", "l": "Joining of adjacent Okazaki fragments (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33392", "l": "C20 sphinganine 1-phosphate + H2O => C20 sphinganine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448678", "l": "CTSG cleaves CASP1(1-404) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53247", "l": "cholesta-5,7-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> cholesta-5,7-dien-3beta,24S-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49716", "l": "3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + H(+) + NADH + O2 = 3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + H2O + NAD(+)"}, {"i": "EC:1.14.13.223", "l": "\"3-hydroxy-4-methyl-anthranilyl-[aryl-carrier protein] 5-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177930", "l": "GAB1 phosphorylation by EGFR kinase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213201", "l": "Formation of collagen fibres (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199456", "l": "PTEN dephosphorylates PIP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176298", "l": "Activation of claspin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21369", "l": "H2O + O2 + urate => 5-hydroxyisourate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11133", "l": "chlorophyllide a + NADP(+) => H(+) + NADPH + protochlorophyllide a"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0016929", "l": "SUMO-specific protease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44691", "l": "a 2-acylglycerol + H2O <=> a fatty acid + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37904", "l": "6-hydroxytryprostatin B + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + tryprostatin A"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050208", "l": "polysialic-acid O-acetyltransferase activity"}, {"i": "MetaCyc:POLYSIALIC-ACID-O-ACETYLTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798372", "l": "ATM phosphorylates DYRK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799409", "l": "HIPK2 phosphorylates TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451895", "l": "IL2RG binds JAK3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53008", "l": "(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = di-trans,poly-cis-polyprenyl diphosphate + n diphosphate"}, {"i": "EC:2.5.1.87", "l": "\"Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61151", "l": "myricetin 3-O-alpha-L-rhamnoside + UDP-alpha-D-glucose <=> H(+) + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3769383", "l": "CBY1 binds beta-catenin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2230983", "l": "LRP1:Hemopexin:heme is endocytosed (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46765", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16898", "l": "a 3beta-hydroxysteroid + a triacylglycerol => a 3beta-hydroxysteroid ester + a diacylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27384", "l": "(2R)-2,3-bisphosphoglycerate + H2O <=> (2R)-2-phosphoglycerate + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070034", "l": "telomerase RNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56477", "l": "(5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 => (4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36558", "l": "eicosanoyl-CoA + sphinganine <=> CoA + H(+) + N-eicosanoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49378", "l": "12,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 12-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015550", "l": "galacturonate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981443", "l": "CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39249", "l": "(2E,11Z)-eicosadienoyl-CoA + H2O => (3R)-hydroxy-(11Z)-eicosenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40589", "l": "CoA + H(+) + octanedioate => H2O + octanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042349", "l": "guiding stereospecific synthesis activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-453338", "l": "PGYM b dimer:AMP complex <=> PGYM dimer, b form + 2 AMP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54796", "l": "a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP(+) = an (R)-2-alkyl-3-oxoalkanoate + H(+) + NADPH"}, {"i": "EC:1.1.1.412", "l": "\"2-alkyl-3-oxoalkanoate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35248", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA(in) + ATP + H2O => ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44473", "l": "1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1-O-alkyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450348", "l": "Activated human JNKs migrate to nucleoplasm (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.133"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12572", "l": "(R)-1-aminopropan-2-ol + adenosylcob(III)yrate + ATP = adenosylcob(III)inamide + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49220", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + CTP = CMP-beta-3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + diphosphate"}, {"i": "EC:2.7.7.92", "l": "\"3-deoxy-D-glycero-D-galacto-nononate cytidylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37750", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-octadecyl-sn-glycero-3-phosphocholine <=> 1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30025", "l": "pyridoxamine 5'-phosphate + pyruvate => L-alanine + pyridoxal 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13966", "l": "H2O + L,L-cystathionine => L-homocysteine + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32683", "l": "5-hydroxymethylfurfural + 2 H2O + 3 O2 = 2,5-dicarboxyfuran + 2 H(+) + 3 H2O2"}, {"i": "EC:1.1.3.47", "l": "\"5-(hydroxymethyl)furfural oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655320", "l": "Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5229343", "l": "AXIN is phosphorylated in the destruction complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814374", "l": "Kazrin binds periplakin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40914", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191830", "l": "snRNP nuclear import and release (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010074", "l": "ADAM10:Zn2+:TSPANs translocates from ER lumen to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49988", "l": "acetone + H(+) + NADPH + O2 = H2O + methyl acetate + NADP(+)"}, {"i": "EC:1.14.13.226", "l": "\"Acetone monooxygenase (methyl acetate-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23159", "l": "(E)-(indol-3-yl)acetaldehyde oxime <=> (indol-3-yl)acetonitrile + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35583", "l": "2-dehydro-3-deoxy-D-gluconate = D-glyceraldehyde + pyruvate"}, {"i": "EC:4.1.2.51", "l": "\"2-dehydro-3-deoxy-D-gluconate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31962", "l": "9beta-pimara-7,15-dien-19-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-dien-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373730", "l": "Neurofascin and NrCAM heterodimerization (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372741", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863463", "l": "STON2 binds SYT proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622415", "l": "RIP2 binds NEMO (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696670", "l": "CHD1L is recruited to GG-NER site (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59140", "l": "ATP + citrate + N(5)-[(S)-citryl]-D-ornithine = AMP + diphosphate + H(+) + staphyloferrin A"}, {"i": "EC:6.3.2.57", "l": "\"Staphyloferrin A synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64651", "l": "(E)-coniferaldehyde + CoA + NADP(+) <=> (E)-feruloyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749197", "l": "ORC1 binds to H4K20me2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014812", "l": "ROBOs bind keratan sulfate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651685", "l": "Defective SLC34A1 does not cotransport Pi, 3Na+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63624", "l": "hexadecanoyl-AMP + holo-[ACP] = AMP + H(+) + hexadecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374701", "l": "Phosphorylation of DCC by Fyn (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32425", "l": "(R)-carvone + AH2 => (1R,4R)-dihydrocarvone + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29092", "l": "a ubiquinone + 5 H(+)(in) + NADH => a ubiquinol + 4 H(+)(out) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353014", "l": "2-phosphoglycerate <=> 3-phosphoglycerate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46331", "l": "L-threo-3-phenylserine <=> 3-phenylpyruvate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033905", "l": "xylan endo-1,3-beta-xylosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57053", "l": "3-oxoisoapionate + H(+) => CO2 + L-erythrulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20244", "l": "nicotinate + S-adenosyl-L-methionine <=> N-methylnicotinate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694401", "l": "E protein gets palmitoylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3134954", "l": "DHX9 binds DNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17883", "l": "D-glucosamine + sulfate => H2O + N-sulfo-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44051", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> 8,9-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49975", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46508", "l": "NADH + nitrobenzene + O2 = catechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32637", "l": "(6E)-8-oxolinalool + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419232", "l": "Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37584", "l": "D-lysine + H2O + O2 => 6-amino-2-oxohexanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664273", "l": "SYK binds IgG:Lma antigens:FCGR3A:p-CD3 dimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668904", "l": "Formation of the CTF18 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58108", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] = acetate + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050560", "l": "aspartate-tRNA(Asn) ligase activity"}, {"i": "MetaCyc:6.1.1.23-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70427", "l": "PGM:Mg2+ isomerise G1P to G6P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627106", "l": "SMAC (DIABLO) forms dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45059", "l": "deoxynogalonate + O2 <=> H(+) + H2O + nogalonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36936", "l": "(11E)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (9Z,11E)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350901", "l": "Iodide is organified (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77068", "l": "Activation of GT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56863", "l": "a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate <=> a 2-oxo-3-(phosphooxy)propyl medium-chain 3-oxoalkanoate + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-844447", "l": "NLRP1 senses MDP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62535", "l": "2 [Fe(II)cytochrome c] + digitoxin + 3 H(+) <=> 2 [Fe(III)cytochrome c] + dihydrodigitoxin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13272", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O <=> an N-acylsphing-4-enine + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11800", "l": "H2O + NAD(+) = AMP + beta-nicotinamide D-ribonucleotide + 2 H(+)"}, {"i": "RHEA:48868", "l": "H2O + NADH = AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide"}, {"i": "EC:3.6.1.22", "l": "\"NAD(+) diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10677", "l": "(2R,3S)-3-isopropylmalate => 2-isopropylmaleate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12126", "l": "CoA + trans-4-coumaroylshikimate => 4-coumaroyl-CoA + shikimate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16345", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (3E,7E)-dolabella-3,7-dien-18-ol + diphosphate"}, {"i": "EC:4.2.3.167", "l": "\"Dolabella-3,7-dien-18-ol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015113", "l": "nitrite transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102594", "l": "cyanidin 7-O-glucoside acyltransferase(acyl-glucose dependent) activity"}, {"i": "MetaCyc:RXN-15372"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801762", "l": "REG3A oligomerize to form a pore complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102282", "l": "3-ketodihydrosphinganine (C18) reductase activity"}, {"i": "MetaCyc:RXN-12641"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43233", "l": "H2O + isatin => H(+) + isatinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176517", "l": "SULTs transfer (SO4)2- group to PREG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55383", "l": "a 3alpha-hydroxy bile acid CoA + NAD(+) <=> a 3-oxo bile acid CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36483", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA = (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450975", "l": "isocitrate <=> citrate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22484", "l": "H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate = GMP + GTP + 2 H(+)"}, {"i": "EC:3.6.1.17", "l": "\"Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)\""}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0030572", "l": "phosphatidyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56382", "l": "(4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 FAD + 4 H2O => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 chloride + 2 FADH2 + 2 O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050231", "l": "putrescine carbamoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72185", "l": "mRNA polyadenylation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.n3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2152276", "l": "Secretion of transmembrane collagens (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983696", "l": "The Immunoglobulin of the BCR binds antigen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52293", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63729", "l": "candesartan + UDP-alpha-D-glucuronate => candesartan-2-N-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53453", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + a cholesterol ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27456", "l": "iodide + L-tyrosine + NADP(+) <=> 3-iodo-L-tyrosine + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102233", "l": "crotonaldehyde redutase activity"}, {"i": "MetaCyc:RXN-12292"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64578", "l": "2 [Fe(II)-cytochrome b5] + H(+) + NADP(+) => 2 [Fe(III)-cytochrome b5] + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66646", "l": "diphosphate + trichobrasilenol => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16895", "l": "N-methylpyridinium + S-adenosyl-L-homocysteine => pyridine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654510", "l": "FGFRL1 binds SPRED1/2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592239", "l": "Expression of PEO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70971", "l": "citrate <=> isocitrate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451310", "l": "Activation of Edited Kainate receptors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49852", "l": "(3E)-octenoyl-CoA = (2E)-octenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451310", "l": "Activation of Edited Kainate receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63967", "l": "sphinga-4E,14Z-dienine-1-phosphate <=> (2E,12Z)-hexadecadienal + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47429", "l": "(3S)-hydroxy-(9Z-octadecenoyl)-CoA + NAD(+) => 3-oxo-(9Z-octadecenoyl)-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710101", "l": "CASP4, CASP5 cleave GSDMD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50988", "l": "prostaglandin F2alpha(out) = prostaglandin F2alpha(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605723", "l": "Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.-.-", "l": "\"Catalysing the translocation amino acids and peptides\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9626928", "l": "CREBBP binds FOXO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044876", "l": "hercynylselenocysteine synthase"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070736", "l": "protein-glycine ligase activity, initiating"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61468", "l": "a cytidine in tRNA + S-adenosyl-L-methionine = a 5-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70482", "l": "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0008603", "l": "cAMP-dependent protein kinase regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018746", "l": "RHOQ binds effectors at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24249", "l": "glyoxylate + L-alanine => glycine + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64475", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + S-adenosyl-L-methionine <=> (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21757", "l": "deacetylisoipecoside + H2O => dopamine + secologanin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396370", "l": "VTN binds collagens II, III and V (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37127", "l": "2-oxoglutarate + dioxidophosphate + H2O2 = CO2 + H(+) + phosphonate + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047370", "l": "succinate-citramalate CoA-transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029268", "l": "Phosphorylation and activation of PLCG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42265", "l": "H(+) + malonyl-[ACP] + octanoyl-CoA => 3-oxodecanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66470", "l": "(17E)-cheilanthenediol => (2E,6E,10E,14E)-geranylfarnesol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31860", "l": "(S)-2,3-epoxysqualene => glutinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614614", "l": "Cysteine is degraded to serine and H2S (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030737", "l": "iodophenol O-methyltransferase activity"}, {"i": "MetaCyc:IODOPHENOL-O-METHYLTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32711", "l": "a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH"}, {"i": "EC:1.1.1.n12", "l": "\"(3R)-hydroxyacyl-CoA dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62347", "l": "6-hydroxydeoxybrevianamide E + dimethylallyl diphosphate <=> diphosphate + notoamide S"}]}
{"type": "biolink:MolecularActivity", "ic": "71.045893708194711", "identifiers": [{"i": "GO:0015145", "l": "monosaccharide transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0048039", "l": "ubiquinone binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26281", "l": "Co-precorrin-5A + H2O = acetaldehyde + Co-precorrin-5B + H(+)"}, {"i": "EC:3.7.1.12", "l": "\"Cobalt-precorrin 5A hydrolase\""}]}
{"type": "biolink:MolecularActivity", "ic": "81.20444558259193", "identifiers": [{"i": "GO:0017076", "l": "purine nucleotide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265010", "l": "Cystine-bonded Proinsulin translocates from the endoplasmic reticulum to the Golgi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110319", "l": "Elongation by POLH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43548", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22541", "l": "5'-dehydroadenosine + H2O + O2 => 9-riburonosyladenine + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5662986", "l": "MT2A binds copper (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61735", "l": "steviol + UDP-alpha-D-glucose <=> H(+) + steviolmonoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875661", "l": "GGA3 associates with activated MET receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24523", "l": "H2O + L-saccharopine + NAD(+) <=> (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381091", "l": "IRE1 dimer autophosphorylates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39172", "l": "3-oxoeicosanoyl-CoA + H(+) + NADPH => (3R)-hydroxyeicosanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983194", "l": "Kinesin-1 is a heterotetramer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031423", "l": "hexon binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33817", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+) => CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27984", "l": "7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate => 7-carboxy-7-deazaguanine + ATP + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11494", "l": "(R)-1-aminopropan-2-yl phosphate + CO2 => H(+) + O-phospho-L-threonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12805", "l": "(S)-canadine + S-adenosyl-L-methionine = (S)-N-methylcanadine + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.122", "l": "\"(S)-tetrahydroprotoberberine N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.7", "l": "\"Ribonuclease F\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.124"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2465940", "l": "atRAL is reduced to atROL (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8934465", "l": "SHC1 binds PTPN12 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28648", "l": "acetophenone + 2 ATP + H2O + hydrogencarbonate => 3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5678327", "l": "MIOX oxidises Ins to GlcA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114683", "l": "Phosphorylation of Platelet Sec-1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028724", "l": "AMOT proteins bind YAP1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806613", "l": "Keratin tetramers bind to form unit length filaments (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043782", "l": "cobalt-precorrin-3 C17-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15396", "l": "(2S,6S)-2,6-diaminoheptanedioate <=> meso-2,6-diaminoheptanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3857336", "l": "CEBPB homodimerization (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13835", "l": "5-guanidino-2-oxopentanoate + L-alanine => L-arginine + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49288", "l": "(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)"}, {"i": "EC:6.3.1.20", "l": "\"Lipoate--protein ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264615", "l": "Loading of acetylcholine in synaptic vesicles (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685606", "l": "CLEC2D binds KLRB1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14316", "l": "2-iodophenol + S-adenosyl-L-methionine <=> 1-iodo-2-methoxybenzene + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388900", "l": "Neurotensin receptors can bind neurotensins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623588", "l": "Defective SLC12A1 does not cotransport Na+, K+, 2Cl- from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209061", "l": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25585", "l": "alpha-L-rhamnose => beta-L-rhamnose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034944", "l": "3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24375", "l": "H2O + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] <=> H(+) + N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73800", "l": "SAICAR => AICAR + Fumarate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63447", "l": "(2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin <=> GMP + H(+) + oxidized coenzyme F420-0"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39883", "l": "dTDP-6-deoxy-alpha-D-allose + NADP(+) = dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48310", "l": "(3Z)-6-oxohex-3-enoyl-CoA + formate + H(+) => 2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109822", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48741", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + O-phospho-L-serine => [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59686", "l": "D-maltohexaono-1,5-lactone + H2O2 => D-maltohexaose + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38492", "l": "2-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050404", "l": "zeatin O-beta-D-xylosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5632652", "l": "Hh-Npp binds CDON and PTCH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56535", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine phosphate <=> N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30308", "l": "7-methylxanthine + H(+) + NADPH + O2 => formaldehyde + H2O + NADP(+) + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445079", "l": "Phosphorylation of L1 by ERK (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66258", "l": "diphosphate + IC-asc-C7-AMP => ATP + H(+) + IC-asc-C7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56931", "l": "abieta-7,13-dien-18-al + O2 + reduced [NADPH--hemoprotein reductase] <=> abieta-7,13-dien-18-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54420", "l": "3',3'-c-di-AMP + H2O = 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+)"}, {"i": "EC:3.1.4.59", "l": "\"Cyclic-di-AMP phosphodiesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3785711", "l": "Telomere shortening during replicative exhaustion (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36600", "l": "hydrogen sulfide + NAD(+) => NADH + sulfur"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23166", "l": "a flavonol 7-O-beta-D-glucoside + H(+) + UDP => a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956026", "l": "CUL9:RBX1 ubiquitinates BIRC5 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.23", "l": "\"[Heparan sulfate]-glucosamine 3-sulfotransferase 1\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2197770", "l": "STAB1 (FEEL-1) binds ligands (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913374", "l": "Phosphorylated SHC1 recruits SHIP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102394", "l": "4-hydroxy-L-isoleucine dehydrogenase activity"}, {"i": "MetaCyc:RXN-13637"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451439", "l": "Activated TLR7 or 21 recruits MyD88 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047551", "l": "2-oxoaldehyde dehydrogenase (NAD+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33471", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-(4R)-4-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446077", "l": "BP230 interacts with keretin K5/K14 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2889070", "l": "SLC9B2 exchanges Na+, Li+ for H+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2214351", "l": "PLK1 phosphorylates GORASP1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60980", "l": "12-hydroxydodecanoate + NAD(+) = 12-oxododecanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162099", "l": "abacavir + UDP-glucuronate => abacavir 5'-glucuronide + UDP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56665", "l": "7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD(+) => 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41740", "l": "adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.219", "l": "\"tRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20324", "l": "L-proline + NAD(+) <=> 1-pyrroline-2-carboxylate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54572", "l": "a uridine in tRNA = a pseudouridine in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5444516", "l": "Formation of MSH2:MSH6 Complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37075", "l": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine"}, {"i": "EC:2.8.4.5", "l": "\"tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9687625", "l": "ATP binds MLKL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0016793", "l": "triphosphoric monoester hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45992", "l": "(3R)-3-hydroxydecanoyl-CoA = (2E)-decenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47667", "l": "H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) <=> 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955844", "l": "RBKS phosphorylates ribose to R5P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33092", "l": "1,4-dihydroxy-6-naphthoate + all-trans-octaprenyl diphosphate + H(+) => 2-demethylmenaquinol-8 + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534378", "l": "Hv1 Mediated H+ Permeability (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18338", "l": "D-ribose 5-phosphate + uracil => H2O + psi-UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046408", "l": "chlorophyll synthetase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64080", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O = 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.1", "l": "\"D-aspartate oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112514", "l": "JAK activation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13370", "l": "dimethylallyl diphosphate => diphosphate + isoprene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912727", "l": "CBL binds VAV (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030773", "l": "6-hydroxymellein O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685605", "l": "SLAMF7 binds SLAMF7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39362", "l": "(13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52544", "l": "D-erythronate + NAD(+) = 2-dehydro-D-erythronate + H(+) + NADH"}, {"i": "EC:1.1.1.410", "l": "\"D-erythronate 2-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50642", "l": "3-(2-methylsulfanyl)ethylmalate => 2-(2-methylsulfanyl)ethylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43926", "l": "H(+) + NADH + pregn-5-ene-3,20-dione => NAD(+) + pregnenolone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38487", "l": "1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57757", "l": "2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH => C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868118", "l": "MAPK12 phosphorylates PTPN3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12381", "l": "L-2,4-diaminobutanoate + pyruvate => L-alanine + L-aspartate 4-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60074", "l": "4beta-hydroxymethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+) => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.40"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8858498", "l": "SL (surrogate light chain) binds IgH to form pre-BCR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15983", "l": "CO2 + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39078", "l": "(2E)-dodecenedioyl-CoA + H2O <=> (3S)-hydroxydodecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34285", "l": "2 L-dopa => 2 L-tyrosine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59379", "l": "4-amino-4-deoxychorismate <=> 4-amino-4-deoxyprephenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12439", "l": "(E)-caffeoyl-CoA + putrescine <=> CoA + H(+) + N-caffeoylputrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55816", "l": "a bacteriochlorophyllide d + H2O + S-adenosyl-L-methionine = 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide d + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23829", "l": "2-dehydro-D-gluconate + NADP(+) => 2,5-didehydro-D-gluconate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25504", "l": "(2E)-geranyl diphosphate = beta-phellandrene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43715", "l": "ATP + dodecanoate + H(+) <=> diphosphate + dodecanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34705", "l": "(E)-2-epi-beta-caryophyllene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617445", "l": "HOXD1 chromatin is activated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388596", "l": "Melanocortin receptors bind melanocortins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433711", "l": "Cis-homodimerization of nectins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28212", "l": "(S)-2-amino-6-oxohexanoate + H2O2 + L-glutamate => H2O + L-saccharopine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187895", "l": "Engulfed CpG DNA binds to endosomal C-ter TLR9 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449855", "l": "IL10 dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15254", "l": "cis-aconitate + H(+) => CO2 + itaconate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134914", "l": "Beta-catenin migrates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194678", "l": "CYP51A1 demethylates LNSOL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36815", "l": "dTDP-alpha-D-fucose = dTDP-alpha-D-fucofuranose"}, {"i": "EC:5.4.99.59", "l": "\"dTDP-fucopyranose mutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69142", "l": "Recruitment of Dna2 endonuclease (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004314", "l": "[acyl-carrier-protein] S-malonyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28860", "l": "Ag(+)(in) + H(+)(in) => Ag(+)(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45756", "l": "(6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2 = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21950", "l": "formate + NH4(+) => formamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420128", "l": "SRC-1 phosphorylates SHB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53233", "l": "cholesta-5,24-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-25-epoxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626549", "l": "IQGAPs bind CALM1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20238", "l": "(1S,4S)-5-oxo-1,2-campholide => [(1R)-2,2,3-trimethyl-2-oxocyclopent-3-en-1-yl]acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198440", "l": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49592", "l": "2-hydroxyisobutanoyl-CoA = (3S)-3-hydroxybutanoyl-CoA"}, {"i": "EC:5.4.99.64", "l": "\"2-hydroxyisobutanoyl-CoA mutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43790", "l": "ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate => acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672083", "l": "KTN1 binds Kinesin-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102737", "l": "p-coumaroyltriacetic acid synthase activity"}, {"i": "MetaCyc:RXN-7577"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40803", "l": "3,6-anhydro-alpha-L-galactopyranose + H2O + NADP(+) = 3,6-anhydro-L-galactonate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25695", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + isopentenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58107", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14296", "l": "D-glucose + NAD(+) <=> D-glucono-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-164832", "l": "ATPase synthesizes ATP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60481", "l": "2 UTP => c-di-UMP + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983424", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050413", "l": "D-alanine 2-hydroxymethyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15096", "l": "2-oxoglutarate + L-tyrosine <=> 3-(4-hydroxyphenyl)pyruvate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696547", "l": "STAMBPL1 is a deubiquitinase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.77"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621615", "l": "CD209 binds ICAM3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13949", "l": "H(+) + NADP(+) + 2 reduced [rubredoxin] = NADPH + 2 oxidized [rubredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53553", "l": "(9S,10R)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(9S,10R)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2509831", "l": "ITPA hydrolyses XTP to XMP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66662", "l": "ADP + beta-D-glucosylceramide(out) + H(+) + phosphate => ATP + beta-D-glucosylceramide(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035485", "l": "adenine/guanine mispair binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14649", "l": "demethyllactenocin + dTDP-beta-L-mycarose = demethylmacrocin + dTDP + H(+)"}, {"i": "EC:2.4.1.318", "l": "\"Demethyllactenocin mycarosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664879", "l": "ATM:PEX5 binds ATM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665311", "l": "ERBB2 T798M does not bind afatinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72691", "l": "Formation of the 43S pre-initiation complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47949", "l": "H2O + thiamine phosphate => phosphate + thiamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20873", "l": "(20S)-ginsenoside Rd + UDP-alpha-D-glucose => (20S)-ginsenoside Rb1 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174444", "l": "Formation of C-strand Okazaki fragments (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25960", "l": "benzoin + NADP(+) = benzil + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60869", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O => a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(7)-methyl-GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202478", "l": "Interaction and oligomerization of MALT1 to Bcl10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63170", "l": "S-(2-succino)-L-cysteine => fumarate + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678694", "l": "Heparanase 2 (HPSE2) cleaves heparan sulfate from its proteoglycan (plasma membrane) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32778", "l": "(2-aminoethyl)phosphonate(out) + ATP + H2O <=> (2-aminoethyl)phosphonate(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66686", "l": "L-cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein] => L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[GAPDH]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031884", "l": "DPAn-6 SPMs translocate from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237160", "l": "MTA is cleaved and phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805730", "l": "SETD9 methylates TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8954056", "l": "E2F6 binds TFDP2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227891", "l": "TRAF3/or TRAF6 interacts with IPS-1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199404", "l": "CD40L binds CD40 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33043", "l": "(1R,4R)-camphor + H(+) + NADPH + O2 = (+)-6-exo-hydroxycamphor + H2O + NADP(+)"}, {"i": "EC:1.14.13.161", "l": "\"(+)-camphor 6-exo-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23871", "l": "(1-hydroxycyclohexan-1-yl)acetyl-CoA <=> acetyl-CoA + cyclohexanone"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016251", "l": "RNA polymerase II general transcription initiation factor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40089", "l": "22-oxodocosanoate + H(+) + NADH => 22-hydroxydocosanoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "58.975624888709277", "identifiers": [{"i": "GO:0022853", "l": "active ion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987007", "l": "p-STAT1 dimerizes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933526", "l": "Recruitment of caspase-8 and -10 to FADD complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23091", "l": "ATP + O-alkylglycerone <=> 1-O-alkylglycerone 3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19670", "l": "GTP + H2O => GDP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.17"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626549", "l": "IQGAPs bind CALM1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45725", "l": "(E)-4-coumaroyl alcohol + NADP(+) => (E)-4-coumaraldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59790", "l": "(2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADH => H2O + NAD(+) + pseudopaline"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0042393", "l": "histone binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21773", "l": "cytidine(6666) in apoB mRNA + H(+) + H2O => NH4(+) + uridine(6666) in apoB mRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043824", "l": "succinylglutamate-semialdehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2032775", "l": "YAP1 binds TEAD1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689000", "l": "AADAC deacetylates PHEN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080066", "l": "3-methylthiopropyl-desulfoglucosinolate sulfotransferase activity"}, {"i": "MetaCyc:RXN-2209"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39280", "l": "ATP + dodecanoate(out) + H2O => ADP + dodecanoate(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202437", "l": "Phosphorylation of CARMA1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102420", "l": "sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39965", "l": "glycerol + H(+) + hexadecanoate => 2-hexadecanoylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14118", "l": "[(1->4)-alpha-D-galacturonosyl](n) + H2O => [(1->4)-alpha-D-galacturonosyl](n-1) + alpha-D-galacturonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24038", "l": "a ribonucleoside 5'-diphosphate + ADP => a ribonucleoside 5'-phosphate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42294", "l": "an acyl phosphate + holo-[ACP] => a fatty acyl-[ACP] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802837", "l": "Loss-of-function NF1 variants don't stimulate RAS GTPase activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390835", "l": "DRD1,5 bind DA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805638", "l": "KAT6A acetylates TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27816", "l": "acetate(out) => acetate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.3.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19849", "l": "H2O + NADP(+) = ADP-D-ribose 2'-phosphate + H(+) + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58353", "l": "2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + O2 => CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14784", "l": "ATP + CoA + heptanedioate <=> 6-carboxyhexanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912734", "l": "CBL:CRKL binds RAPGEF1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952807", "l": "p-Y693-STAT4 dissociates after IL12:IL12R interaction (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59227", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + hydropyrene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49484", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(in) + ATP + H2O = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014293", "l": "RAC2 GDIs block activation of RAC2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54988", "l": "4 e(-) + 4 H(+)(in) + O2(in) = 2 H2O(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019531", "l": "oxalate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018793", "l": "3,5-dibromo-4-hydroxybenzoate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44607", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O <=> a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1067640", "l": "IL6 binds IL6R-2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43461", "l": "dodecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-undecylpyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9681294", "l": "IL6R binds IL6R inhibitors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227709", "l": "Activated MDA5 binds IPS-1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9654533", "l": "KRAS4B recycles to the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44722", "l": "a 1-acyl-sn-glycerol + H(+) + phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56883", "l": "a 3beta-hydroxy-Delta(5)-steroid + NADP(+) <=> a 3-oxo-Delta(5)-steroid + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31943", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25S)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22383", "l": "[(1->4)-alpha-D-galacturonosyl methyl ester](n) + n H2O <=> [(1->4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864569", "l": "WWOX binds TFAP2C (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28658", "l": "glutathione S,S-dioxide + H2O <=> glutathione + H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13543", "l": "H(+) + sulfate + sulfur + thiosulfate => H2O + tetrathionate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20132", "l": "AMP + H2O <=> adenine + D-ribose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432909", "l": "Interaction of Plectin with Integrin beta 4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52481", "l": "16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase] => (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64024", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8),N'(8)-citryl-bis(spermidine) = H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0005338", "l": "nucleotide-sugar transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49919", "l": "(R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102408", "l": "sn-2-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity"}, {"i": "MetaCyc:RXN-13735"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005169", "l": "neurotrophin TRKB receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786421", "l": "CHIA hydrolyses chitin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5607721", "l": "Activation of NIK (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853956", "l": "Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1 and inhibited by VENTX:TCF4,LEF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53685", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 => 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937814", "l": "RUNX3 translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63653", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022456", "l": "MECP2 binds 5mC-DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981622", "l": "Myoglobin:oxygen dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64617", "l": "(E)-coniferol + acetyl-CoA => (E)-coniferyl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48630", "l": "a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine => a ribonucleotide in rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031210", "l": "phosphatidylcholine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41499", "l": "1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53359", "l": "5,6-dihydrouridine(20b) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(20b) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130194", "l": "ABL phosphorylates WAVEs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6791221", "l": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15918", "l": "an aldopyranose + NAD(+) => aldono-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63972", "l": "A + dihydropyriculol = AH2 + pyriculol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59948", "l": "H2O + prostaglandin F2alpha-CoA = CoA + H(+) + prostaglandin F2alpha"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36653", "l": "H(+) + novobiocic acid + S-adenosyl-L-homocysteine => 8-desmethylnovobiocic acid + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707516", "l": "FeHM dissociates from MetHb (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35329", "l": "3-oxodocosanoyl-CoA + CO2 + CoA => eicosanoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.47"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371435", "l": "Constitutive phosphorylation by GSK3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51669", "l": "2 H(+) + mevastatin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pravastatin lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874685", "l": "CBL binds MET (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102332", "l": "fatty-acyl-[acp] elongase/decarboxylase activity"}, {"i": "MetaCyc:RXN-13260"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008043", "l": "MAPK8 phosphorylation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710354", "l": "GSDME (1-270) binds cardiolipin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205652", "l": "Pink1 recruits Parkin to the outer mitochondrial membrane. (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017174", "l": "glycine N-methyltransferase activity"}, {"i": "RHEA:32463", "l": "glycine + 2 S-adenosyl-L-methionine = 2 H(+) + N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.156", "l": "\"Glycine/sarcosine N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985950", "l": "p-Y649-STAT5A, p-STAT5B dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13936", "l": "all-trans-retinyl hexadecanoate + H2O <=> all-trans-retinol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450494", "l": "HuR binds mRNAs in the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1912372", "l": "Fringe-modified Pre-NOTCH is cleaved by FURIN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10070", "l": "4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP => 4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33789", "l": "3-keto-beta-D-galactose + beta-D-glucose => 3'-ketolactose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41973", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E)) => CMP + ganglioside GT1aalpha (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47536", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH = isochenodeoxycholate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50356", "l": "4-hydroxy-6-methylpretetramide + NADPH + O2 = 4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+)"}, {"i": "EC:1.14.13.233", "l": "\"4-hydroxy-6-methylpretetramide 12a-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649701", "l": "NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10318", "l": "5-hydroxymethyluracil + CO2 + succinate => 2-oxoglutarate + O2 + thymine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35535", "l": "cyclo(L-phenylalanyl-L-leucyl) + O2 = cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811454", "l": "MAPKs phosphorylate PP2A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30981", "l": "AH2 + all-trans-3,4-didehydrolycopene => A + all-trans-lycopene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53560", "l": "9,10-epoxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-9,10-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56548", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17687", "l": "CO2 + uracil => H(+) + uracil 5-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28680", "l": "3-demethylubiquinol-8 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14841", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = ent-copalyl diphosphate"}, {"i": "EC:5.5.1.13", "l": "\"Ent-copalyl diphosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45019", "l": "5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine <=> L-selenomethionine + tetrahydropteroyltri-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41786", "l": "CMP + ganglioside GM1 (d18:1(4E)/18:0) + H(+) => asialo-GM1a ganglioside (d18:1(4E)/18:0) + CMP-N-acetyl-beta-neuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18275", "l": "4-aminobutanal + H2O2 + NH4(+) => H2O + O2 + putrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004509", "l": "steroid 21-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-451033", "l": "(S)-Malate <=> Fumarate + H2O (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29496", "l": "(2E,6E)-farnesyl diphosphate + H2O => beta-eudesmol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685608", "l": "CLEC2B binds KLRF1 dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193700", "l": "p75NTR ICD signals to NF-kB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21392", "l": "2-phenylacetaldehyde + H2O + NAD(+) = 2-phenylacetate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.39", "l": "\"Phenylacetaldehyde dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63156", "l": "H2O + N-docosanoyl-taurine = docosanoate + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70475", "l": "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61257", "l": "H2O + L-cysteine + O2 => 2-oxo-3-sulfanylpropanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41674", "l": "1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-sn-glycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4608855", "l": "PRICKLE1 is degraded by the proteasome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39832", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoate + O2 => 2-hydroxyhexadecanoate + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65562", "l": "H2O + kynurenate + L-glutamate => 2-oxoglutarate + L-kynurenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28674", "l": "2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28259", "l": "cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate => cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66835", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + preasperterpenoid A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2213207", "l": "Formation of collagen networks (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209244", "l": "REL binds to DREDD in the PGN:PGRP-LC oligomer receptor 'signalling complex' (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49303", "l": "D-maltose(out) + N(pros)-phospho-L-histidyl-[protein] <=> alpha-maltose 6'-phosphate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2317314", "l": "AKT binds PDPK1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3857336", "l": "CEBPB homodimerization (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798374", "l": "DYRK2 phosphorylates TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61335", "l": "ATP + H2O + indoxyl sulfate(in) <=> ADP + H(+) + indoxyl sulfate(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9663511", "l": "BIL binds GSTA1, FABP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59044", "l": "dammarenediol-II + UDP-alpha-D-glucose = (20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25674", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate"}, {"i": "EC:3.1.3.78", "l": "\"Phosphatidylinositol-4,5-bisphosphate 4-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0099583", "l": "neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36530", "l": "(11Z)-eicosenoyl-CoA + H(+) + malonyl-CoA <=> (13Z)-3-oxodocosenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033823", "l": "procollagen glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52405", "l": "3-dehydro-4-O-phospho-L-erythronate + H(+) => CO2 + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018617", "l": "4-aminobenzenesulfonate 3,4-dioxygenase (deaminating) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12396", "l": "dTDP-D-galactose + H2O + 2 NADP(+) = dTDP-D-galacturonate + 3 H(+) + 2 NADPH"}, {"i": "EC:1.1.1.186", "l": "\"dTDP-galactose 6-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39296", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + AH2 + O2 => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15663", "l": "an anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] + CoA => (E)-4-coumaroyl-CoA + an anthocyanidin 3,5-di-O-beta-D-glucoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28434", "l": "(9Z)-hexadecenoyl-(Kdo)2-lipid IVA + tetradecanoyl-[ACP] = ((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209309", "l": "Phosphorylated REL-68 transports from the cytosol to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200646", "l": "Cytosolic folate export across the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380620", "l": "Reuptake of serotonin from the synapse (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34186", "l": "alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose <=> alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036140", "l": "peptidyl-asparagine 3-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12915", "l": "(R)-lipoyl-5'-AMP + diphosphate => (R)-lipoate + ATP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404135", "l": "RBP4 binds atROL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933530", "l": "Activation of IKK by MEKK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211960", "l": "CYP2U1 19-hydroxylates ARA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4411383", "l": "NLK phosphorylates TCF/LEF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791084", "l": "Expression of SYVN1 (HRD1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52519", "l": "trans-4-hydroxy-L-proline + ubiquinone-10 <=> (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + H(+) + ubiquinol-10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13673", "l": "[protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate"}, {"i": "EC:2.7.7.59", "l": "\"[Protein-PII] uridylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848586", "l": "Transport of cytosolic HXOL to the peroxisome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25631", "l": "H(+) + laricitrin + S-adenosyl-L-homocysteine => myricetin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72631", "l": "Formation of the cap-binding eIF4F complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29896", "l": "ATP + H2O + L-glutamine(out) => ADP + H(+) + L-glutamine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62631", "l": "a hydroperoxide + H(+) + NADH <=> an alcohol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-921155", "l": "p-STAT5 dissociates from the receptor complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693324", "l": "Disulfiram covalently modifies Cys191 in GSDMD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44510", "l": "1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62873", "l": "(3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + H(+) + NADPH + O2 => H2O + NADP(+) + semiviriditoxin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40459", "l": "(2S)-pristanoyl-CoA + O2 = (2E)-pristenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977371", "l": "Factor I inactivates Factor H-boundC3b (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60872", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O = a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(7)-methyl-GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27677", "l": "ATP + dADP <=> ADP + dATP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097244", "l": "flavonol binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29405", "l": "3-demethylubiquinol-8 + A + H2O => 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052633", "l": "isocitrate hydro-lyase (cis-aconitate-forming) activity"}, {"i": "KEGG.REACTION:R01900"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266350", "l": "CETP-mediated lipid exchange: LDL gains cholesterol ester (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102201", "l": "(+)-2-epi-prezizaene synthase activity"}, {"i": "MetaCyc:RXN-12117"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654511", "l": "FGFRL1 dimer binds FGFs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380272", "l": "Plk1-mediated phosphorylation of Nlp (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951727", "l": "cAMP binds PKA tetramer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58700", "l": "FADH2-C4alpha-hydroperoxide + NADPH + rifampicin = FADH2 + H(+) + H2O + NADP(+) + rifampicin hemiaminal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21709", "l": "H2O + S-adenosyl-L-homocysteine => adenosine + L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809521", "l": "BPIF binds bacteria (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17092", "l": "2-dehydro-3-deoxy-6-phospho-D-gluconate <=> D-glyceraldehyde 3-phosphate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27602", "l": "(2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate = di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10549", "l": "L-arginine + O2 => 4-guanidinobutanamide + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0005451", "l": "monovalent cation:proton antiporter activity"}, {"i": "REACT:R-HSA-2889070", "l": "SLC9B2 exchanges Na+, Li+ for H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16506", "l": "chorismate => 4-hydroxybenzoate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634442", "l": "KLF5 gene expression is enhanced by CEBPA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65649", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(28-hydroxyoctacosanoyl)-sphing-4-enine => a diacylglycerol + N-(28-(9Z,12Z-octadecadienoyloxy)-octacosanoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56478", "l": "(4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "75.324974028080362", "identifiers": [{"i": "GO:0005267", "l": "potassium channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58980", "l": "citral + H2O + O2 = 3,7-dimethylocta-2,6-dienoate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.4.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14345", "l": "H(+) + L-tyrosine = CO2 + tyramine"}, {"i": "EC:4.1.1.25", "l": "\"Tyrosine decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20161", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + sucrose = myo-inositol + raffinose"}, {"i": "EC:2.4.1.82", "l": "\"Galactinol--sucrose galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806629", "l": "Formation of tonofilament bundles (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19231", "l": "an aromatic carboxylate + ATP + H(+) + NADPH => AMP + an aromatic aldehyde + diphosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102570", "l": "tyrosine:phenylpyruvate aminotransferase activity"}, {"i": "MetaCyc:RXN-15200"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18562", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) => 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810392", "l": "TMEM55B translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52428", "l": "12-oxo-leukotriene B4 + H(+) + NADH = 12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "65.166422153683129", "identifiers": [{"i": "GO:0016765", "l": "transferase activity, transferring alkyl or aryl (other than methyl) groups"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211206", "l": "Translocation of DFF to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.13", "l": "\"Glutathione gamma-glutamate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73945", "l": "FAS-mediated dimerization of procaspase-8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59308", "l": "D-galactono-1,5-lactone + H2O = D-galactonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65360", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O = a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19115", "l": "(8Z,11Z,14Z)-heptadecatrienoate + AH2 + H(+) => (8Z,11Z,14Z)-heptadecatrienal + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65026", "l": "dehydrocholate + H(+) + NADPH => 7alpha-hydroxy-3,12-dioxo-5beta-cholanate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10300", "l": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40418", "l": "H2O + pristanoyl-CoA <=> 2,6,10,14-tetramethylpentadecanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798749", "l": "Exocytosis of specific granule lumen proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66575", "l": "2-naphthol + 3'-phosphoadenylyl sulfate <=> 2-naphthyl sulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54697", "l": "4-hydroxybenzoate + ATP + holo-[4-hydroxyphenylalkanoate synthase] => 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37515", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2002466", "l": "Formation of allysine by LOX (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33018", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + H(+) + NADPH + O2 <=> [(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56793", "l": "2 cob(II)alamin--[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] => 2 [corrinoid adenosyltransferase]-cob(I)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166753", "l": "Conversion of C4 into C4a and C4b (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61754", "l": "H(+) + rebaudioside B + UDP => steviolbioside + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56737", "l": "H2O + O2 + retinal => H(+) + H2O2 + retinoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008750", "l": "NAD(P)+ transhydrogenase (AB-specific) activity"}, {"i": "MetaCyc:1.6.1.2-RXN"}, {"i": "EC:1.6.1.2", "l": "\"NAD(P)(+) transhydrogenase (Re/Si-specific)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-434362", "l": "Recruitment Of Cytoplasmic Proteins To Vesicles (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5679266", "l": "Beclin-1 complex translocates to the ER (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187332", "l": "Cytosolic CMs translocate to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50977", "l": "prostaglandin D2(out) => prostaglandin D2(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37025", "l": "(6Z)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => 2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47727", "l": "glutathione <=> 5-oxo-L-proline + L-cysteinylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29569", "l": "2 chloride(out) + H(+)(in) => 2 chloride(in) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61718", "l": "ADP + D-galactofuranose(in) + H(+) + phosphate => ATP + D-galactofuranose(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665702", "l": "ERBB2 TMD/JMD mutants bind TKIs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1462003", "l": "HNP1-4 are stored in primary neutrophil granules (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3266557", "l": "Factor I cleaves iC3b (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710323", "l": "TP53 or TP63 binds the GSDME gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22582", "l": "(2Z)-2-hydroxypenta-2,4-dienoate + H2O => (S)-4-hydroxy-2-oxopentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58616", "l": "N-octanoyl-(2S)-hydroxyglycine = glyoxylate + octanamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36122", "l": "gibberellin A9 + S-adenosyl-L-methionine <=> O-methyl gibberellin A9 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63846", "l": "2-phenylpropan-2-ol + [thioredoxin]-disulfide + H2O => [thioredoxin]-dithiol + cumene hydroperoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13824", "l": "2-oxoglutarate + glutarate + O2 <=> (S)-2-hydroxyglutarate + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21568", "l": "beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O = beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose"}, {"i": "EC:3.2.1.140", "l": "\"Lacto-N-biosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39364", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA => (2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804402", "l": "TP53 binds POU4F1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607757", "l": "K63polyUb-TRAF6 ubiquitinates TAK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57128", "l": "H2O + 2 oxidized [azurin] + tyramine = (4-hydroxyphenyl)acetaldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418925", "l": "ADORA2A,B bind Ade-Rib (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429694", "l": "CERT:PPM1L:VAPA/B [ER] => CERT [cytosol] + PPM1L:VAPA/B [ER] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050285", "l": "sinapine esterase activity"}, {"i": "KEGG.REACTION:R02381"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48305", "l": "a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198508", "l": "malate + NAD+ <=> oxaloacetate + NADH + H+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047930", "l": "glucosaminate ammonia-lyase activity"}, {"i": "MetaCyc:4.3.1.21-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43088", "l": "5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109860", "l": "MAP2K1 phosphorylates MAPK3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3222237", "l": "SMYD2 methylates TP53 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12763", "l": "3 H(+) + precorrin-4 + S-adenosyl-L-homocysteine => precorrin-3B + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36395", "l": "cholesta-5,7-dien-3beta-ol + NADP(+) = cholesta-5,7,24-trien-3beta-ol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299359", "l": "Activation of TALK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941312", "l": "ZCCHC6, ZCCHC11 are mRNA uridyltransferases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018648", "l": "methanesulfonate monooxygenase activity"}, {"i": "RHEA:26077", "l": "methanesulfonate + NADH + O2 = formaldehyde + H2O + NAD(+) + sulfite"}, {"i": "EC:1.14.13.111", "l": "\"Methanesulfonate monooxygenase (NADH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60112", "l": "(R)-3-(indol-3-yl)lactoyl-CoA = (E)-3-(indol-3-yl)acryloyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5679205", "l": "ULK1 phosphorylates Beclin-1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936851", "l": "AHRR binds ARNT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57814", "l": "3-chlorocatechol + NAD(+) + nitrite => 1-chloro-2-nitrobenzene + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786421", "l": "CHIA hydrolyses chitin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42184", "l": "5alpha-androstane-3beta,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41454", "l": "3-hydroxy-5-methyl-1-naphthoate + H2O + NADP(+) => 5-methyl-1-naphthoate + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432371", "l": "CRY is activated by light and binds to phosphorylated nuclear TIM (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10123", "l": "adenosine in double-stranded RNA + H(+) + H2O <=> inosine in double-stranded RNA + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69173", "l": "Joining of adjacent Okazaki fragments (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11834", "l": "H(+) + NADH + naphthalene-1,2-diol => (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106264", "l": "protein serine kinase activity (using GTP as donor)"}, {"i": "RHEA:64020", "l": "GTP + L-seryl-[protein] = GDP + H(+) + O-phospho-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016150", "l": "translation release factor activity, codon nonspecific"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58781", "l": "a 5'-triphospho-guanosine-ribonucleotide-snRNA + S-adenosyl-L-methionine => a 5'-methyltriphosphate-guanosine-ribonucleotide-snRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408543", "l": "SeCysta is hydrolysed to Sec by PXLP-K212-CTH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190065", "l": "Activated TrkA receptor internalizes to endosomes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36614", "l": "(3S,5S)-carbapenam-3-caboxylate + 2-oxoglutarate + O2 <=> (5R)-carbapenem-3-carboxylate + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23317", "l": "2'-deoxyuridine + 2-oxoglutarate + O2 => 2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102727", "l": "3beta-hydroxysteroid dehydrogenase activity"}, {"i": "MetaCyc:RXN-710"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050639", "l": "10-hydroxytaxane O-acetyltransferase activity"}, {"i": "RHEA:18837", "l": "10-deacetyltaxuyunnanin C + acetyl-CoA = CoA + taxuyunnanin C"}, {"i": "EC:2.3.1.163", "l": "\"10-hydroxytaxane O-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66709", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => 2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635102", "l": "GPR161 is internalized (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3341294", "l": "Superoxide reduces cytochrome c (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033969", "l": "gamma-glutamyl-gamma-aminobutyrate hydrolase activity"}, {"i": "RHEA:19737", "l": "4-(gamma-L-glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate"}, {"i": "EC:3.5.1.94", "l": "\"Gamma-glutamyl-gamma-aminobutyrate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9679029", "l": "C-ter TLR7 dimer binds HCQ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031723", "l": "CXCR4 chemokine receptor binding"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015148", "l": "D-xylose transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57470", "l": "1-O-[(E)-feruloyl]-beta-D-glucose + UDP => (E)-ferulate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032031", "l": "myosin I head/neck binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61144", "l": "myricetin + UDP-beta-L-rhamnose = H(+) + myricetin 3-O-alpha-L-rhamnoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65593", "l": "8-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] => 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700171", "l": "Active ALK phosphorylates PLCG1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15206", "l": "a dolichyl diphosphooligosaccharide + H2O => an oligosaccharide-(1->4)-N-acetyl-beta-D-glucosamine-(1->4)-N-acetyl-alpha-D-glucosamine 1-phosphate + dolichyl phosphate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20294", "l": "3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) => 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44419", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607002", "l": "Activated protein C cleaves factor VIIIa (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48922", "l": "3,8-divinyl chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin] => ADP + bacteriochlorophyllide g + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419490", "l": "Binding of ATP to P2X receptors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140696", "l": "factor V -> factor Va + factor V activation peptide (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592314", "l": "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391158", "l": "SIRP alpha binds CD47 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374337", "l": "Apelin receptor binds to apelin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23709", "l": "[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate => [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434018", "l": "Autophosphorylation of chicken IRAK4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810076", "l": "DDO oxidizes D-Asp to OA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50315", "l": "2-oxopentanoate + H(+) <=> butanal + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201603", "l": "Caspase-mediated cleavage of PKC theta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56503", "l": "(R)-3,5-bisphosphomevalonate + H(+) <=> CO2 + isopentenyl phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23497", "l": "5-hydroxypentanoate + acetyl-CoA => 5-hydroxy-pentanoyl-CoA + acetate"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0070513", "l": "death domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050022", "l": "L-arabinose 1-dehydrogenase (NAD+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210271", "l": "Interaction of DAP12 and MDL-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39212", "l": "(3R)-hydroxyhexacosanoyl-CoA => (2E)-hexacosenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11663", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O <=> a 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33554", "l": "an N-acylsphinganine + H2O <=> a fatty acid + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692768", "l": "MAPKAPK5 phosphorylates KALRN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.-", "l": "\"Acid--ammonia (or amine) ligases (amide synthases)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18328", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-amorpha-4,11-diene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13099", "l": "a (2E)-enoyl-[ACP] + H2O => a (3R)-hydroxyacyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61752", "l": "steviolbioside + UDP-alpha-D-glucose = H(+) + rebaudioside B + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018768", "l": "2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9663511", "l": "BIL binds GSTA1, FABP1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50996", "l": "L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.127", "l": "\"[Ribulose-bisphosphate carboxylase]-lysine N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395784", "l": "Nascent CMs transform into mature CMs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42535", "l": "uridine(55) in tRNA <=> pseudouridine(55) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-976768", "l": "Factor H binds to C3b (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902444", "l": "riboflavin binding"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0015269", "l": "calcium-activated potassium channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51485", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34529", "l": "(S)-3-amino-3-phenylpropanoate => L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1980122", "l": "DTX binds NOTCH1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20885", "l": "H2O + L-serine + NAD(+) => 3-hydroxypyruvate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51382", "l": "CoA + H(+) + N-(9Z-octadecanoyl)-dopamine => (9Z)-octadecenoyl-CoA + dopamine"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0019112", "l": "phenanthrol glycosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114254", "l": "CYCS binds to APAF1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50295", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610760", "l": "GLI1 is degraded by the proteasome after ubiquitination by ITCH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16235", "l": "2-dehydropantoate + H(+) + NADPH => (R)-pantoate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15964", "l": "4-hydroxymandelonitrile + UDP-alpha-D-glucose <=> H(+) + taxiphyllin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52085", "l": "13-octadecanoyloxy-octadecanoate + H2O => 13-hydroxy-octadecanoate + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8874718", "l": "TTPA binds alpha-TOH (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34781", "l": "a 3-oxosteroid + H(+) + NADH => a 3alpha-hydroxysteroid + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052928", "l": "CTP:3'-cytidine-tRNA cytidylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102523", "l": "2-chloroacrylate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052859", "l": "glucan endo-1,4-beta-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694333", "l": "3CLp forms a homodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24533", "l": "2-methylbutanoyl-CoA + NAD(+) => 2-methylbut-2-enoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26090", "l": "(4S)-limonene + H(+) + NADH + O2 => H2O + limonene 1,2-epoxide + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26249", "l": "H(+) + levopimaradienol + NADPH + O2 = 2 H2O + levopimaradienal + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25276", "l": "ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate <=> ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63463", "l": "(2E,6E,10E)-geranylgeraniol + GTP <=> (2E,6E,10E)-geranylgeranyl phosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102290", "l": "beta-amyrin monooxygenase activity"}, {"i": "MetaCyc:RXN-12681"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204392", "l": "Basigin binds MCT1, MCT3 and MCT4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13095", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP => an N-acylsphing-4-enine + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40346", "l": "3-oxohexadecanedioyl-CoA + CoA <=> acetyl-CoA + tetradecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617815", "l": "BBSome binds RAB3IP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005161", "l": "platelet-derived growth factor receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5683792", "l": "p-T68-CHEK2 autophosphorylates (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53108", "l": "2-hydroxyestrone + S-adenosyl-L-methionine = 2-hydroxy-3-methoxy-estrone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.64"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17873", "l": "ATP + cob(III)alamin(out) + H2O = ADP + cob(III)alamin(in) + H(+) + phosphate"}, {"i": "EC:7.6.2.8", "l": "\"ABC-type vitamin B12 transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637800", "l": "Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51931", "l": "H2O + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD(+) <=> (S)-2,3-diaminopropanoate + 2-oxoglutarate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50438", "l": "prostaglandin E1 => prostaglandin H1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41594", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+) => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9654533", "l": "KRAS4B recycles to the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047568", "l": "3-oxo-5-beta-steroid 4-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41543", "l": "8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + S-adenosyl-L-methionine <=> 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052722", "l": "fatty acid in-chain hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44356", "l": "nogalaviketone = methyl nogalonate"}, {"i": "EC:5.5.1.26", "l": "\"Nogalonic acid methyl ester cyclase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140761", "l": "sequestered tissue factor -> tissue factor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39745", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32652", "l": "erythromycin D + S-adenosyl-L-methionine => erythromycin B + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29854", "l": "H2O + UDP-N-acetyl-alpha-D-galactosamine <=> 2 H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39876", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol => a 1-acyl-sn-glycero-3-phosphocholine + a 2,3-diacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49804", "l": "2-methylpropan-1-amine + FMNH2 + O2 = FMN + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59367", "l": "1-octadecanoyl-2-(9,10-epoxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphoserine + 9,10-epoxyoctadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203979", "l": "Coat Assembly (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018511", "l": "2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46294", "l": "a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate => a 5'-end triphospho-(purine-ribonucleoside) in mRNA + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2106615", "l": "Removal of siRNA passenger strand (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66528", "l": "ATP + O-(5'-adenylyl)-L-tyrosyl-[protein] = diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32282", "l": "allantoate + 2 H(+) + 2 H2O <=> (S)-ureidoglycolate + CO2 + 2 NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-947499", "l": "Exchange of oxygen with sulfur in MoCo (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32362", "l": "1D-myo-inositol 1,4,5-trisphosphate + 2 ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65221", "l": "(1S,2S)-1,2-dihydrobenzene-1,2-diol + NADP(+) => catechol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19827", "l": "(+)-aristolochene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13540", "l": "(2R)-3-phosphoglycerate + GDP-alpha-D-mannose <=> 2-O-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32633", "l": "erythromycin C + H2O + NADP(+) => erythromycin D + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008332", "l": "low voltage-gated calcium channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419645", "l": "Dimerization of LIMK1 by Hsp90 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067659", "l": "Assembly of hexameric IL-6 receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112514", "l": "JAK activation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35822", "l": "5,6,7,8-tetrahydromethanopterin + NADP(+) <=> 7,8-dihydromethanopterin + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22421", "l": "cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD(+) => 2 H(+) + maleylacetate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683792", "l": "p-T68-CHEK2 autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38128", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol => 1-octadecanoyl-2-(9Z)-octadecenoylglycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61897", "l": "betaenone C => betaenone A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62020", "l": "H2O + sitosteryl 3-beta-D-glucoside = (24R)-ethylcholest-5-en-3beta-ol + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9007882", "l": "IL1F10 is cleaved (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-181450", "l": "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035497", "l": "cAMP response element binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56187", "l": "globoside Gb4Cer + UDP-alpha-D-galactose <=> globoside NOR1 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18904", "l": "H(+) + H2O + N-benzyloxycarbonyl-L-leucine <=> benzyl alcohol + CO2 + L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653974", "l": "Ragulator binds Rag dimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35214", "l": "dIDP + H2O <=> dIMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44877", "l": "a 1,3-diacylglycerol + H2O => 3-acyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656254", "l": "Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52193", "l": "(E)-phenylacetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] => (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29037", "l": "ADP + H(+) + L-glutamate(in) + phosphate => ATP + H2O + L-glutamate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12730", "l": "lutein => (3R,3'S)-zeaxanthin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65307", "l": "2-oxoglutarate + O2 + verruculide A <=> chrodrimanin T + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17621", "l": "acetyl-CoA + citramalate = (3S)-citramalyl-CoA + acetate"}, {"i": "EC:2.8.3.11", "l": "\"Citramalate CoA-transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189439", "l": "ALAD condenses 2 dALAs to form PBG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37982", "l": "2-methyl-6-phytyl-1,4-benzene-1,4-diol + S-adenosyl-L-methionine <=> 2,3-dimethyl-6-phytylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382053", "l": "Translocation of PDGF from ER to Golgi (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.12", "l": "\"dCTP diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10600", "l": "prostaglandin H2 = prostaglandin D2"}, {"i": "EC:5.3.99.2", "l": "\"Prostaglandin-D synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62576", "l": "ATP + H2O + L-cystine(out) = ADP + H(+) + L-cystine(in) + phosphate"}, {"i": "RHEA:62580", "l": "ATP + D-cystine(out) + H2O = ADP + D-cystine(in) + H(+) + phosphate"}, {"i": "EC:7.4.2.12", "l": "\"ABC-type cystine transporter\""}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0001848", "l": "complement binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10778", "l": "3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH => (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210274", "l": "SIRP beta binds TYROBP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390930", "l": "5-HT2 receptor can bind serotonin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55494", "l": "ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2-one + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694419", "l": "SARS-CoV-2 gRNA complement (minus strand):RTC binds RTC inhibitors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66345", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + ATP + H2O => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15616", "l": "NAD(+) + precorrin-2 <=> 2 H(+) + NADH + sirohydrochlorin"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0061791", "l": "GTPase motor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58969", "l": "1-naphthaldehyde + H2O + O2 => 1-naphthoate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001227", "l": "DNA-binding transcription repressor activity, RNA polymerase II-specific"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5252133", "l": "ATP6AP1 binds V-ATPase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852013", "l": "BTNL8 binds resting T cell surface (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45528", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60850", "l": "a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + L-lysyl-[protein] => a 5'-end diphospho-guanosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16177", "l": "H2O + NAD(+) + retinal = 2 H(+) + NADH + retinoate"}, {"i": "RHEA:42080", "l": "all-trans-retinal + H2O + NAD(+) = all-trans-retinoate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.36", "l": "\"Retinal dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17702", "l": "ATP + geranoyl-CoA + hydrogencarbonate => 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0016849", "l": "phosphorus-oxygen lyase activity"}, {"i": "EC:4.6.-.-", "l": "\"Phosphorus-oxygen lyases\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052607", "l": "7-hydroxy-chlorophyllide a oxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21543", "l": "N-(5-phospho-beta-D-ribosyl)anthranilate <=> 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610722", "l": "CK1 phosphorylates p-GLI3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645481", "l": "TIFA oligomerization (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39000", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O => a 1-acyl-sn-glycero-3-phosphate + H(+) + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662823", "l": "PLK2, MAPK14 phosphorylate ADAM17 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031925", "l": "pyridoxal transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912398", "l": "NOTCH1 binds DNER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19511", "l": "2 H(+) + L-erythro-biopterin + 2 NADPH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624130", "l": "Myristoylated NPHP3 translocates into the ciliary membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38058", "l": "CTP + phytol <=> CDP + H(+) + phytyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418850", "l": "Activation of Cdc42 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23953", "l": "H2O + N-(2-phenylethyl)acetamide => 2-phenylethylamine + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41917", "l": "H(+) + hexadecanoyl-[ACP] + malonyl-[ACP] => 3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38573", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(out) => a 1,2-diacyl-sn-glycero-3-phosphocholine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52978", "l": "a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin] => a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9612501", "l": "SGK phosphorylates CREB1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211206", "l": "Translocation of DFF to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8980691", "l": "RHOA GEFs activate RHOA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60768", "l": "3 2-oxoglutarate + gibberellin A12 + 3 O2 = 3 CO2 + gibberellin A25 + H(+) + H2O + 3 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17576", "l": "demethylmacrocin + S-adenosyl-L-methionine <=> H(+) + macrocin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.52", "l": "\"Trimerelysin I\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018754", "l": "ammelide aminohydrolase activity"}, {"i": "MetaCyc:RXN-8017"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928625", "l": "PAKs autophosphorylate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433418", "l": "Phosphorylation of JAK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13708", "l": "alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + UDP-N-acetyl-alpha-D-glucosamine <=> alpha-D-Man-(1->3)-[alpha-D-GlcNAc-(1->2)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.233"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44278", "l": "4-hydroxy-6-(2-oxohenicosyl)pyran-2-one + 3 CO2 + 4 CoA => eicosanoyl-CoA + 3 H(+) + 3 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351478", "l": "Association of gamma-H2AX with MCPH1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33894", "l": "chanoclavine-I + NAD(+) <=> chanoclavine-I aldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62548", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D-galactose = beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43763", "l": "acetyl-CoA + N-terminal L-seryl-[ribosomal protein bL12] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[ribosomal protein bL12]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33142", "l": "L-alanine(out) + L-aspartate(in) <=> L-alanine(in) + L-aspartate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-350598", "l": "Arginine<=>Agmatine+CO2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18499", "l": "L-xylulose 5-phosphate => L-ribulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047111", "l": "formate dehydrogenase (cytochrome-c-553) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30535", "l": "biotinate sulfoxide + H(+) + NADPH = biotin + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37008", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72691", "l": "Formation of the 43S pre-initiation complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61506", "l": "pelargonidin 3-O-beta-D-glucoside + UDP => pelargonidin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675417", "l": "PEBP1 binds activated RAF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849906", "l": "SALM1 binds NMDA receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392834", "l": "Activation of EPACs by cAMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851988", "l": "BTN2A2 binds T cell surface (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2002440", "l": "Removal of fibrillar collagen C-propeptides (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21175", "l": "L-idonate + NAD(+) <=> 5-dehydro-D-gluconate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60290", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37696", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA => 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28649", "l": "3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate => acetophenone + 2 ATP + H2O + hydrogencarbonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16679", "l": "fluoroacetate + 2 H(+) + NADH => fluoroacetaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29540", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35957", "l": "6-hydroxytryprostatin B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13393", "l": "diphosphate + nicotinate beta-D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54259", "l": "2-oxoglutarate + L-histidyl-[protein] + O2 <=> (3S)-3-hydroxy-L-histidyl-[protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46477", "l": "4alpha-hydroxymethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0031701", "l": "angiotensin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193653", "l": "NGF homodimer binds to p75NTR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43407", "l": "N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose <=> H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28279", "l": "3-sulfino-L-alanine + H2O => H(+) + L-alanine + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682465", "l": "RTC completes synthesis of the minus strand genomic RNA complement (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16776", "l": "ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose <=> ganglioside GM1 (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111264", "l": "Addition of nucleotides between position +11 and +30 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390909", "l": "HRH2 binds hist (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10271", "l": "2-dehydro-3-deoxy-D-glucarate <=> 2-hydroxy-3-oxopropanoate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5213466", "l": "RIPK3 is phosphorylated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353271", "l": "Cleavage of uracil by Uracil-glycosylase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "63.331851047434839", "identifiers": [{"i": "GO:0140097", "l": "catalytic activity, acting on DNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42677", "l": "L-cysteine + L-histidine + O2 => H2O + L-alanin-3-yl L-histidin-5-yl sulfoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700662", "l": "(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951549", "l": "Carbocymycobactin binds Fe3+ from LTF:2xFe3+:2xCO3(2-) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004662", "l": "CAAX-protein geranylgeranyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450474", "l": "MK2 phosphorylates BRF1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53467", "l": "1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14238", "l": "10-deoxysarpagine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sarpagine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22671", "l": "2-N,3-O-bis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine <=> H(+) + lipid A disaccharide (E. coli) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682026", "l": "MRN bound to shortened telomeres activates ATM (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63898", "l": "isoaspulvinone E => aspulvinone E + hnu"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54799", "l": "a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP(+) <=> an (R)-2-alkyl-3-oxoalkanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43401", "l": "N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose => H(+) + N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944257", "l": "Association of procollagen type XXIV (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636242", "l": "PPE2:KPNA1:KPNB1 dissociates, releasing PPE2 into the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61864", "l": "AH2 + dehydroprobetaenone I = A + probetaenone I"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56008", "l": "4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) = 4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33953", "l": "2'''-acetyl-6'''-hydroxyneomycin C + H(+) + UDP => ribostamycin + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839095", "l": "p-BCR-pFGFR1 binds GRB2:GAB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806831", "l": "CYB5Rs reduce MetHb to HbA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031686", "l": "A1 adenosine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623643", "l": "RDH13 reduces atRAL to atROL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30433", "l": "taraxerol => (S)-2,3-epoxysqualene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66781", "l": "6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine + H2O => N-acetyl-D-glucosamine + N-acetyl-D-muramate 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209210", "l": "STAT92E is phosphorylated by phosphorylated HOP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38055", "l": "CTP + phytol = CDP + H(+) + phytyl phosphate"}, {"i": "EC:2.7.1.182", "l": "\"Phytol kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10830", "l": "AMP + anthraniloyl-CoA + diphosphate => anthranilate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984606", "l": "Kinesin-5 is a homotetramer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "79.238648346243679", "identifiers": [{"i": "GO:0015923", "l": "mannosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45423", "l": "H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine <=> a fatty acid + H(+) + N-acyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24794", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54331", "l": "2 H(+) + hexadecanoyl-[ACP] + 2 NADPH <=> hexadecan-1-ol + holo-[ACP] + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41653", "l": "aclacinomycin S + dTDP-2-deoxy-beta-L-fucose => 2-deoxy-alpha-L-fucosylaclacinomycin S + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24311", "l": "25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "78.047734625335977", "identifiers": [{"i": "GO:0005179", "l": "hormone activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38136", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol => 1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008761", "l": "UDP-N-acetylglucosamine 2-epimerase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102177", "l": "24-methylenelophenol methyl oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54864", "l": "H(+) + NADPH + O2 + sulcatone = 4-methylpent-3-en-1-yl acetate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852354", "l": "GTSE1 facilitates proteasome-mediated degradation of TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16598", "l": "ATP + NH4(+) + UTP => ADP + CTP + 2 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13353", "l": "4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol = 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)"}, {"i": "EC:2.7.8.14", "l": "\"CDP-ribitol ribitolphosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646390", "l": "Misfolded proteins:HDAC6:Dynein motor binds microtubule (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23642", "l": "CO2 + ethene + 2 H2O + hydrogen cyanide + L-dehydroascorbate => 1-aminocyclopropane-1-carboxylate + L-ascorbate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189439", "l": "ALAD condenses 2 dALAs to form PBG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805479", "l": "TP53RK phosphorylates TP53 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31186", "l": "acetyl-CoA + decanoyl-CoA <=> 3-oxododecanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9009072", "l": "STAT3 phosphorylation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11033", "l": "(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate => 3-chloro-cis,cis-muconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022462", "l": "MECP2 mutants R133C ,D121G, R133H and S134F do not bind 5hmC-DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57805", "l": "1-chloro-3-nitrobenzene + NADH + O2 => 4-chlorocatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784160", "l": "IL10 negatively regulates extracellular inflammatory mediators (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41558", "l": "(3R)-3-hydroxy-L-arginyl-[ribosomal protein uL16] + CO2 + succinate => 2-oxoglutarate + L-arginyl-[ribosomal protein uL16] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170674", "l": "Dissociation of the Gi alpha:G olf complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64662", "l": "a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate => a long-chain fatty acid + ATP + holo-[(phenol)carboxyphthiodiolenone synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981355", "l": "RASA1 binds RAS:GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25573", "l": "geranylgeranyl diphosphate + 2 H2O => diphosphate + sclareol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.243", "l": "\"6(G)-fructosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814387", "l": "CASP14 cleaves filaggrin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5262921", "l": "Defective IKBKG (NEMO) destabilizes the association of IKBKA:IKBKB:IKBKG (via TLR) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55243", "l": "1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O <=> (9Z)-octadecenoate + 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5689630", "l": "BAP1 binds BAP1-interacting complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13007", "l": "H(+) + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-homocysteine => (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62553", "l": "beta-D-glucosylceramide + UDP-alpha-D-galactose => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928640", "l": "PAKs phosphorylate MLC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12144", "l": "cyanidin 3-O-rutinoside + UDP-alpha-D-glucose = cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + H(+) + UDP"}, {"i": "RHEA:24861", "l": "pelargonidin 3-O-rutinoside + UDP-alpha-D-glucose = H(+) + pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP"}, {"i": "EC:2.4.1.116", "l": "\"Cyanidin 3-O-rutinoside 5-O-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036461", "l": "BLOC-2 complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50283", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (5S)-hydroperoxy-(14R,15S)-epoxy-(6E,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022770", "l": "MECP2 binds SGK1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24445", "l": "GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[(1->4)-alpha-L-Fuc]-beta-D-GlcNAc}-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15508", "l": "2-(hydroxymethyl)glutarate + NAD(+) <=> 2-formylglutarate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11023", "l": "1D-myo-inositol 1,4,5-trisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38376", "l": "bacterioruberin => bisanhydrobacterioruberin + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013145", "l": "RAC1 binds effectors at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047188", "l": "aromatic-hydroxylamine O-acetyltransferase activity"}, {"i": "RHEA:20325", "l": "N-hydroxy-4-acetylaminobiphenyl = N-acetoxy-4-aminobiphenyl"}, {"i": "EC:2.3.1.56", "l": "\"Aromatic-hydroxylamine O-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57507", "l": "3-hydroxybutane-1,2,3-tricarboxylate <=> pyruvate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601922", "l": "Complexed PIWIL2 binds cleaved transposon RNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201639", "l": "Caspase-mediated cleavage of GAS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0042287", "l": "MHC protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23454", "l": "ADP + dAMP + H(+) => 2'-deoxyadenosine + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928631", "l": "GIT1 binds bPIX (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013024", "l": "RHOB binds effectors at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374664", "l": "Phosphorylation and activation of Ezrin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40465", "l": "(9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+) => 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.129"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149492", "l": "cob(II)alamin dissociates from MMACHC:MMADHC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.163", "l": "\"Demethylmenaquinone methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55292", "l": "pseudouridine(54) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.257", "l": "\"tRNA (pseudouridine(54)-N(1))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35665", "l": "a 1-acyl-sn-glycerol + a fatty acid + H(+) => a 1,2-diacyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23151", "l": "ATP + propanoate <=> ADP + propanoyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66815", "l": "5-aminopentanoate + acetyl-CoA + 20 H(+) + 8 malonyl-CoA + 13 NADPH <=> 8 CO2 + 9 CoA + 7 H2O + 13 NADP(+) + wortmanamide B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806613", "l": "Keratin tetramers bind to form unit length filaments (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687520", "l": "MetAsp transforms to L-Asp,isoAsp (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "80.155824608458104", "identifiers": [{"i": "GO:0015174", "l": "basic amino acid transmembrane transporter activity"}, {"i": "REACT:R-HSA-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Homo sapiens)"}, {"i": "REACT:R-HSA-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668253", "l": "Hyperactivation of factor X by FVIIIa:FIXa R384L (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32798", "l": "ATP + H2O + L-cysteine(out) <=> ADP + H(+) + L-cysteine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10760", "l": "citrate = acetate + oxaloacetate"}, {"i": "EC:4.1.3.6", "l": "\"Citrate (pro-3S)-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46557", "l": "5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + cholesta-5,7-dien-3beta-ol + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707606", "l": "PGRMC2:Hemes translocate to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097363", "l": "protein O-GlcNAc transferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034279", "l": "syn-pimara-7,15-diene synthase activity"}, {"i": "KEGG.REACTION:R09117"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65548", "l": "ganglioside Fuc-GM1 + H2O = alpha-Fuc-(1->2)-beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-Glc + an N-acyl-sphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24044", "l": "3,4-dihydroxybenzoate + O2 = 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)"}, {"i": "EC:1.13.11.8", "l": "\"Protocatechuate 4,5-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39678", "l": "(9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64809", "l": "acetyl-CoA + O-(2-aminoethyl)-L-serine => CoA + H(+) + O-(2-acetamidoethyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18564", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) <=> 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33490", "l": "(4R)-hydroxysphinganine + 2-hydroxyhexacosanoyl-CoA <=> CoA + H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55235", "l": "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 [Fe(II)-cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 2 [Fe(III)-cytochrome b561] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11775", "l": "6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27304", "l": "3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 => 7-chloro-L-tryptophan + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40502", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45998", "l": "a 2-oxocarboxylate + a quinol + NH4(+) => a D-alpha-amino acid + a quinone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67020", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.57", "l": "\"Methyltransferase cap1\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40808", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50886", "l": "(9Z-octadecenoyl)-glycerol + phosphate => (9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016887", "l": "ATP hydrolysis activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60793", "l": "3 2-oxoglutarate + gibberellin A53 + 3 O2 => 3 CO2 + gibberellin A17 + H(+) + H2O + 3 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196929", "l": "FLAD1 phosphorylates FMN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49189", "l": "a bacteriochlorophyllide d => a 3-vinylbacteriochlorophyllide d + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45876", "l": "2-methylhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 6-(hexadecan-2-yl)-4-hydroxy-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416320", "l": "Trafficking of GluR1-containing  AMPA receptors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32613", "l": "(6E)-8-oxogeranial + H(+) + NADPH => (6E)-8-hydroxygeranial + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602484", "l": "Activation of proMMP11 by FURIN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839039", "l": "Tyrosine kinase inhibitors bind and inhibit cytosolic FGFR1 fusion dimer phosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49238", "l": "L-histidyl-[protein] + sucrose 6(G)-phosphate(in) => N(pros)-phospho-L-histidyl-[protein](out) + sucrose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051434", "l": "BH3 domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47135", "l": "11-cis-retinal + H2O + NAD(+) <=> 11-cis-retinoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183051", "l": "CBL ubiquitinates Sprouty (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-976768", "l": "Factor H binds to C3b (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31037", "l": "(S)-2,3-epoxysqualene + H2O => arabidiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295632", "l": "PPA2A dephosphorylates SPRY2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35310", "l": "H(+) + NADH + O2 + salicylate <=> 2,5-dihydroxybenzoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23061", "l": "a (2R,3S)-2-alkyl-3-hydroxyalkanoate + ATP => a cis-3-alkyl-4-alkyloxetan-2-one + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39653", "l": "3-hydroxy-6-carboxyhexanoyl-CoA + H(+) => 6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052582", "l": "(+)-menthofuran synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654163", "l": "Activated FGFR4 binds PLCG1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44823", "l": "1,4-dihydroxy-2-naphthoate + all-trans-tridecaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-13 + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112435", "l": "Formation of Elongin BC complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404139", "l": "HSC cytosolic atROL translocates to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47228", "l": "docosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41386", "l": "H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165195", "l": "GTP loading by Rheb (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41249", "l": "9R-hydroperoxy(5Z,7E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050186", "l": "phosphoadenylylsulfatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64800", "l": "NAD(+) + S-(2-aminoethyl)-L-cysteine = (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + 2 H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34738", "l": "a fatty acyl-CoA + sphinganine <=> an N-acylsphinganine + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-179421", "l": "Degradation of multiubiquitinated Nek2A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36272", "l": "caffeine + H(+) + NADPH + O2 => formaldehyde + H2O + NADP(+) + theobromine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851988", "l": "BTN2A2 binds T cell surface (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63095", "l": "H(+) + ilicicolin A + NADPH + O2 <=> H2O + ilicicolin A epoxide + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047699", "l": "beta-diketone hydrolase activity"}, {"i": "KEGG.REACTION:R03781"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65299", "l": "(2R)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48466", "l": "ganglioside GA1 + N-acetylneuraminate => ganglioside GM1b + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41805", "l": "3-oxobutanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxybutanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57738", "l": "AH2 + all-trans-3,4-didehydroretinol => A + all-trans-3,4-didehydro-13,14-dihydroretinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043997", "l": "histone acetyltransferase activity (H4-K12 specific)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072518", "l": "Rho-dependent protein serine/threonine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416690", "l": "SEMA4A binds to PLXND1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61734", "l": "H(+) + steviolmonoside + UDP => steviol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158164", "l": "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29472", "l": "D-ribose 5-phosphate + H2O => D-ribose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20390", "l": "(2R,3R)-dihydroquercetin + H(+) + NADPH + O2 => (2R,3R)-2,3-dihydrogossypetin + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395364", "l": "LTBP4 binds TGF-Beta-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59691", "l": "D-maltoheptaose + O2 <=> D-maltoheptaono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66025", "l": "hypobromite + L-lysyl-[collagen] + L-methionyl-[collagen] => [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44865", "l": "a triacyl-sn-glycerol + H2O => a 1,2-diacylglycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25138", "l": "phosphate + pyridoxamine <=> H2O + pyridoxamine 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10081", "l": "dihydrophloroglucinol + NADP(+) => 1,3,5-trihydroxybenzene + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176517", "l": "SULTs transfer (SO4)2- group to PREG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57141", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30623", "l": "A + all-trans-neurosporene = AH2 + all-trans-lycopene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-919404", "l": "Phosphorylated STAT5 is released (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61941", "l": "3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + UDP-alpha-D-glucose => 3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418200", "l": "SRC-1 bound to ARRB2 is not activated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29725", "l": "glyoxylate(out) => glyoxylate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193642", "l": "Binding of pro-NGF to p75NTR:sortilin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36988", "l": "CMP + phosphate => alpha-D-ribose 1,5-bisphosphate + cytosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17099", "l": "enol-phenylpyruvate => 3-phenylpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373739", "l": "Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669250", "l": "PAK1 phosphorylates FLNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37689", "l": "1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22579", "l": "an N-acyl-L-homoserine lactone + H2O <=> an N-acyl-L-homoserine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45095", "l": "H2O + N-octanoylsphing-4-enine <=> octanoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635843", "l": "GLI translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663122", "l": "p-BMAL1:p-CLOCK,NPAS2 binds NAMPT gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800035", "l": "IGFBP3 binds TMEM219 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451311", "l": "Activation of Ca-permeable Kainate receptors (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707523", "l": "Hemes bind to BACH1:MAFK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51569", "l": "(25S)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17283", "l": "H2O + L-ectoine => (2S)-4-acetamido-2-aminobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10894", "l": "(2S)-2-isopropyl-3-oxosuccinate + H(+) + NADH => (2R,3S)-3-isopropylmalate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28241", "l": "calycosin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + pseudobaptigenin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437192", "l": "PDPK1 binds PRKCZ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29876", "l": "H2O + sn-glycero-3-phospho-L-serine => H(+) + L-serine + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450422", "l": "KSRP recruits RNA degradation activities (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33050", "l": "(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] <=> (+)-6-endo-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202692", "l": "PIP3 binds to RhoA and activates it (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27882", "l": "2',3'-cyclic CMP + H2O = 3'-CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45212", "l": "[Co(I) corrinoid Fe-S protein] + acetyl-CoA + H(+) = [methyl-Co(III) corrinoid Fe-S protein] + CO + CoA"}, {"i": "EC:2.3.1.169", "l": "\"CO-methylating acetyl-CoA synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034932", "l": "1-methoxypyrene 6,7-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218815", "l": "p-6Y-VEGFR2 binds NCK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28988", "l": "H(+)(in) + N-acetylneuraminate(in) => H(+)(out) + N-acetylneuraminate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22533", "l": "(2E)-octenedioyl-CoA + H2O => (3S)-hydroxyoctanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14837", "l": "glyoxylate + H2O + O2 = H(+) + H2O2 + oxalate"}, {"i": "EC:1.2.3.5", "l": "\"Glyoxylate oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.2.11", "l": "\"Phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029468", "l": "Conversion of PA into DAG by PAP-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43303", "l": "alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP-N-acetyl-alpha-D-galactosamine <=> H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-glycoloylneuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204600", "l": "Basigin homodimerises (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54043", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (3E,7E)-dolathalia-3,7,11-triene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58726", "l": "H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine => adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1467466", "l": "ABCA4 mediates atRAL transport (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65315", "l": "an ultra-long-chain mono-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] <=> a 3-oxo-ultra-long-chain mono-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43840", "l": "26-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (3beta)-hydroxy-cholest-5-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58660", "l": "a 5'-(5'-phosphomethyl)-ribonucleoside-RNA + S-adenosyl-L-methionine = a 5'-(5'-bisphosphomethyl)-ribonucleoside-RNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57221", "l": "GTP + methylglyoxal => N(2)-(1-hydroxy-2-oxopropyl)-GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23582", "l": "prostaglandin I2 => prostaglandin H2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5220959", "l": "TDG excises 5-formylcytosine (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24367", "l": "H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD(+) <=> 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012556", "l": "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.37"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54921", "l": "13-cis-retinol + NADP(+) => 13-cis-retinal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13313", "l": "H2O + O2 + sarcosine = formaldehyde + glycine + H2O2"}, {"i": "EC:1.5.3.1", "l": "\"Sarcosine oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15372", "l": "2,3-dihydroxybenzoate + O2 <=> 2-carboxy-cis,cis-muconate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76031", "l": "2 H2O2 => O2 + 2 H2O (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201443", "l": "Type II receptor phosphorylates type I receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657786", "l": "NR1H2,3 binds the APOD gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2265534", "l": "Defective GLB1 does not hydrolyse a glycosaminoglycan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038047", "l": "morphine receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18296", "l": "ATP + CoA + oxalate <=> AMP + diphosphate + oxalyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033019", "l": "5-hydroxyvalerate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21872", "l": "L-arginyl-[cytochrome c] + S-adenosyl-L-methionine = H(+) + N(omega)-methyl-L-arginyl-[cytochrome c] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052691", "l": "UDP-arabinopyranose mutase activity"}, {"i": "RHEA:28350", "l": "UDP-beta-L-arabinofuranose = UDP-beta-L-arabinopyranose"}, {"i": "EC:5.4.99.30", "l": "\"UDP-arabinopyranose mutase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047263", "l": "N-acylsphingosine galactosyltransferase activity"}, {"i": "RHEA:13093", "l": "an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005020", "l": "stem cell factor receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013992", "l": "TRAF3 binds to TRIF:activated TLR3 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58456", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O = (R)-glycerate + D-mannose"}, {"i": "EC:3.2.1.170", "l": "\"Mannosylglycerate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65794", "l": "3-[3-(trifluoromethyl)phenyl]-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => fluometuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16301", "l": "H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50083", "l": "ATP + H2O + taurodeoxycholate(in) <=> ADP + H(+) + phosphate + taurodeoxycholate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159773", "l": "Furin cleaves pro-protein S to protein S (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683735", "l": "CHEK2 is recruited to DNA DSBs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27674", "l": "ATP + dADP = ADP + dATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52159", "l": "(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> (R)-mandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070005", "l": "cysteine-type aminopeptidase activity"}, {"i": "EC:3.4.18.-", "l": "\"Cysteine-type carboxypeptidases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35067", "l": "(S)-carnitine(out) = (S)-carnitine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018572", "l": "EGFR phosphorylates NOTCH3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44870", "l": "1,2-diacyl-sn-glycero-3-phosphoethanol + choline => a 1,2-diacyl-sn-glycero-3-phosphocholine + ethanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029476", "l": "Role of myosins in phagosome formation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102587", "l": "cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-O-(glucosyl)-p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoylglucose glucosyltransferase activity"}, {"i": "MetaCyc:RXN-15333"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51252", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012556", "l": "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679205", "l": "ULK1 phosphorylates Beclin-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647994", "l": "RAS proteins are depalmitoylated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22665", "l": "2 1-O-(trans-sinapoyl)-beta-D-glucose => 1,2-di-O-sinapoyl beta-D-glucose + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38183", "l": "19-hydroxytestosterone + O2 + reduced [NADPH--hemoprotein reductase] = 19-oxotestosterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019982", "l": "interleukin-7 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9015111", "l": "Factor Xa inhibitors binds Xa (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19902", "l": "L-tryptophan + O2 => alpha,beta-didehydrotryptophan + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43199", "l": "adenosine(4) in tRNA(His) + S-adenosyl-L-methionine <=> 2'-O-methyladenosine(4) in tRNA(His) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12309", "l": "(S)-2-amino-6-oxohexanoate + H2O + NAD(+) => 2 H(+) + L-2-aminoadipate + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000107", "l": "imidazoleglycerol-phosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448702", "l": "Caspase-1 active tetramer formation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11910", "l": "butanoate + H(+) + pentan-2-one => H2O + nonane-4,6-dione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44316", "l": "1-dodecanoylglycerol + H2O = dodecanoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372529", "l": "Release of acetylcholine at the synapse (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163310", "l": "TFAM binds to mitochondrial promoters (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45125", "l": "acarbose + ATP => acarbose 7(IV)-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56850", "l": "H(+) + reumycin + S-adenosyl-L-homocysteine => 1,6-didemethyltoxoflavin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675194", "l": "Activated MAPK phosphorylates RAF1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853801", "l": "PSPN binds RET:GFRA4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047573", "l": "4-acetamidobutyrate deacetylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52983", "l": "a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] <=> 7-oxoheptanoyl-[ACP] + a fatty aldehyde + H(+) + 2 H2O + oxidized [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9646685", "l": "Aggresome dissociates from dynein and microtubule (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59185", "l": "2,4-diacetylphloroglucinol + H2O => 2-acetylphloroglucinol + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474210", "l": "Collagen type III degradation by MMP14 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39743", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24698", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A = 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + a 1,2-diacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2090079", "l": "GLB1 hydrolyses linker chain(2) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938217", "l": "RUNX1 binds the SWI/SNF complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10111", "l": "(7S)-salutaridinol + NADP(+) <=> H(+) + NADPH + salutaridine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60103", "l": "cyanidin + UDP-alpha-D-glucose <=> cyanidin 3-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25450", "l": "(+)-guaia-6,9-diene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022875", "l": "protein-N(PI)-phosphohistidine-galactitol phosphotransferase system transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102590", "l": "delphinidin 3-O-rutinoside 7-O-glucosyltransferase (acyl-glucose dependent) activity"}, {"i": "MetaCyc:RXN-15351"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420975", "l": "Ca impermeable AMPA receptor ligand binding (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50673", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O => [(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65591", "l": "(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56880", "l": "a 3beta-hydroxy-Delta(5)-steroid + NADP(+) = a 3-oxo-Delta(5)-steroid + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086038", "l": "calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358790", "l": "RNF41 ubiquitinates ERBB3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59520", "l": "ATP + butanoyl-CoA + hydrogencarbonate = (2S)-ethylmalonyl-CoA + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034317", "l": "nicotinic acid riboside kinase activity"}, {"i": "MetaCyc:RXN-8443"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65372", "l": "CMP-N-acetyl-beta-neuraminate + globoside GalGb4Cer = CMP + globoside MSGG + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17801", "l": "acetyl-CoA + L-phenylalanine = CoA + H(+) + N-acetyl-L-phenylalanine"}, {"i": "EC:2.3.1.53", "l": "\"Phenylalanine N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39548", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA => (2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016170", "l": "interleukin-15 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13962", "l": "ATP + H2O + Mg(2+) + protoporphyrin IX => ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60831", "l": "a 5'-end triphospho-adenosine in mRNA + H2O <=> a 5'-end diphospho-adenosine in mRNA + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372910", "l": "pyruvate + NADH + H+ <=> lactate + NAD+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005000", "l": "vasopressin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28731", "l": "H(+)(out) + L-leucine(in) = H(+)(in) + L-leucine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686335", "l": "CSF2RA:CSF2RB binds SFTPs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23385", "l": "D-cellobiose => beta-D-glucosyl-(1->4)-D-mannopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205244", "l": "Recruitment of CBL to KIT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008131", "l": "primary amine oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57424", "l": "guaiacol + O2 + reduced [NADH--hemoprotein reductase] = catechol + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53849", "l": "NAD(+) + taurocholate => 7-oxo-taurodeoxycholate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507871", "l": "Aquaporins passively transport glycerol out of cells (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0000014", "l": "single-stranded DNA endodeoxyribonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9661625", "l": "FVIII is secreted (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35872", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19287", "l": "a 1-acyl-sn-glycero-3-phosphocholine + acyldolichol => a 1,2-diacyl-sn-glycero-3-phosphocholine + di-trans,poly-cis-dolichol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11635", "l": "AH2 + L-selenocysteine <=> A + H(+) + hydrogenselenide + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34059", "l": "agroclavine + NADP(+) = didehydroagroclavine + H(+) + NADPH"}, {"i": "EC:1.5.1.46", "l": "\"Agroclavine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164840", "l": "ADP and Pi bind to ATPase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43638", "l": "2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34071", "l": "trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP"}, {"i": "EC:2.7.8.35", "l": "\"UDP-N-acetylglucosamine--decaprenyl-phosphate N-acetylglucosaminephosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17207", "l": "adenosine 3',5'-bisphosphate + H(+) + quercetin 3,4'-bissulfate => 3'-phosphoadenylyl sulfate + quercetin 3-sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8862380", "l": "HSD17B13 binds lipid droplets (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35690", "l": "NADP(+) + tetradecasphinganine <=> 3-oxotetradecasphinganine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048408", "l": "epidermal growth factor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46465", "l": "(24S)-25-epoxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S,25)-epoxy-7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682026", "l": "MRN bound to shortened telomeres activates ATM (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66880", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 10-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605624", "l": "Beta-galactosidase hydrolyses GM1 to GM2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41312", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl (5Z,8Z,10E,12R,14Z)-hydroperoxyiecosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37761", "l": "1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52676", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine"}, {"i": "EC:3.5.1.132", "l": "\"[Amino group carrier protein]-ornithine hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-996755", "l": "ZFPM proteins bind GATA proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164506", "l": "Gap repair completes provirus integration (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663118", "l": "p-BMAL1:p-CLOCK,NPAS2 binds PER2 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625123", "l": "Defective SLC20A2 does not cotransport Pi, Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49275", "l": "alfacalcidol + O2 + reduced [NADPH--hemoprotein reductase] <=> calcitriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62917", "l": "an N-terminal L-alpha-aminoacyl-[protein] + 3 S-adenosyl-L-methionine => an N-terminal trimethyl-L-alpha-aminoacyl-[protein] + 3 H(+) + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65103", "l": "a 1-acylglycerol + hexadecanoyl-CoA <=> an hexadecanoyl-acylglycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654511", "l": "FGFRL1 dimer binds FGFs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52568", "l": "epitestosterone + UDP-alpha-D-glucuronate = epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14365", "l": "2 H(+) + H2O + N-carbamoyl-L-aspartate = CO2 + L-aspartate + NH4(+)"}, {"i": "EC:3.5.1.7", "l": "\"Ureidosuccinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375138", "l": "CDO binds BOC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624948", "l": "KIF17 enters the cilium (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858480", "l": "WNT-dependent phosphorylation of DVL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876446", "l": "p-ULK1 phosphorylates DENND3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38260", "l": "(2R,3S)-beta-methylmalyl-CoA => glyoxylate + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21777", "l": "(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA => (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604763", "l": "Autocatalytic activation of MMP7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53725", "l": "ATP + N-acetyl-D-glucosamine => ADP + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.69"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421493", "l": "succinyl-CoA + glycine => delta-aminolevulinate + CoA SH + CO2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57630", "l": "H2O + ML-236C carboxylate => 3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809521", "l": "BPIF binds bacteria (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36538", "l": "docosanoyl-CoA + sphinganine <=> CoA + H(+) + N-docosanoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051269", "l": "alpha-keto ester reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16063", "l": "choline + H(+) + sn-glycerol 3-phosphate => H2O + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52297", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10670", "l": "1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18271", "l": "ethyl 3-oxohexanoate + H(+) + NADPH => ethyl (S)-3-hydroxyhexanoate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61232", "l": "H2O + L-isoleucine + O2 = (S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015476", "l": "hemaglutinin autotransporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549304", "l": "OCT3 mediates renal clearance of organic cations (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37004", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(13Z,16Z,19Z)-docosatrienoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57438", "l": "acetaldehyde + catechol + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => guaethol + O2 + reduced [NADH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56046", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56263", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP-alpha-D-galactose <=> 4 H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033740", "l": "hydroxylamine oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22888", "l": "(R)-methylmalonyl-CoA = succinyl-CoA"}, {"i": "EC:5.4.99.2", "l": "\"Methylmalonyl-CoA mutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.21", "l": "\"L-carnitine CoA-transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070043", "l": "rRNA (guanine-N7-)-methyltransferase activity"}, {"i": "REACT:R-HSA-6790982", "l": "WBSCR22:TRMT112 methylates guanosine-1639 of 18S rRNA yielding 7-methylguanosine-1639 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52698", "l": "a 1,2-diacyl-3-O-[alpha-D-galactopyranosyl-(1->2)-alpha-D-glucopyranosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57425", "l": "guaiacol + O2 + reduced [NADH--hemoprotein reductase] => catechol + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34757", "l": "D-glucose + N-acyl-15-methylhexadecasphing-4-enine => H2O + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55335", "l": "a 3'-hydroxyflavone + S-adenosyl-L-methionine <=> a 3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34288", "l": "2 L-dopa + O2 => 2 H2O + 2 L-dopaquinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40915", "l": "1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49929", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "64.054900825907879", "identifiers": [{"i": "GO:0016628", "l": "oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"}, {"i": "REACT:R-HSA-9661745", "l": "An unknown BILR reduces BIL to D-UBGN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60906", "l": "13-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090588", "l": "protein-phosphocysteine-N-acetylmuramate phosphotransferase system transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29044", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH => (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15680", "l": "5-aminopentanamide + H2O <=> 5-aminopentanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59916", "l": "(2E)-octenal + H2O + NADP(+) = (2E)-octenoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57623", "l": "dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202721", "l": "JAM2 binds JAM3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018608", "l": "1-indanone dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653936", "l": "Formation of Ragulator complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56611", "l": "5,10-methylenetetrahydrosulfopterin + glycine + H2O <=> L-serine + tetrahydrosulfopterin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65494", "l": "5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + CO2 + L-methionine => [mycofactocin precursor peptide]-C-terminal glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11711", "l": "H2O + IMP + NAD(+) <=> H(+) + NADH + XMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42427", "l": "2-methylmaleate + H2O <=> (2R,3S)-3-methylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674397", "l": "Imatinib-resistant PDGFR mutants don't bind imatinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-481007", "l": "Exocytosis of platelet alpha granule contents (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60240", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35045", "l": "N-(4-aminobenzoyl)-L-glutamate(out) => N-(4-aminobenzoyl)-L-glutamate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53611", "l": "4-hydroxyestrone + O2 <=> (2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34933", "l": "glutathione + hydrogenselenide + NADP(+) => glutathioselenol + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19779", "l": "AH2 + H(+) + L-1-piperideine-6-carboxylate => A + L-pipecolate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61993", "l": "N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2509827", "l": "ITPA hydrolyses ITP to IMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57258", "l": "GTP + H(+) + lactate => H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653957", "l": "Rag dimer formation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14383", "l": "4-guanidinobutanoate + 2 H(+) + NADH => 4-guanidinobutanal + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373073", "l": "Receptors CCR1, 2 and 8 bind CCL16 ligand (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869683", "l": "oxPL binds LBP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166817", "l": "Cleavage of C3 by C3 convertases (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57782", "l": "3-chloro-4-methylcatechol + NAD(+) + nitrite => 2-chloro-4-nitrotoluene + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977392", "l": "Expression of CEBPD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190682", "l": "Connexin synthesis (generic) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22276", "l": "2-oxoaldehyde + H2O + NAD(+) = a 2-oxocarboxylate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.23", "l": "\"2-oxoaldehyde dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.48", "l": "\"Low-specificity L-threonine aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853496", "l": "SCF:FBXL7 binds AURKA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44456", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = a 1-acyl-sn-glycero-3-phosphocholine + a 1-O-acyl-N-acylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008882", "l": "[glutamate-ammonia-ligase] adenylyltransferase activity"}, {"i": "MetaCyc:GSADENYLATION-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64605", "l": "L-seryl-[protein] + UTP => diphosphate + uridylyl-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114684", "l": "Phosphorylation of Syntaxin-4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050250", "l": "retinal oxidase activity"}, {"i": "RHEA:22520", "l": "all-trans-retinal + H2O + O2 = all-trans-retinoate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16306", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O => 3-hydroxy-3-methylglutarate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25618", "l": "terpentedienyl diphosphate => diphosphate + terpentetriene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60834", "l": "a 5'-end diphospho-guanosine in mRNA + H(+) + phosphate => a 5'-end triphospho-guanosine in mRNA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102571", "l": "[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33955", "l": "DIBOA + UDP-alpha-D-glucose = DIBOA beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5681980", "l": "ATG12 binds ATG7 dimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61313", "l": "germacra-1(10),4,11(13)-trien-12-ol + O2 + reduced [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804596", "l": "APAF1:CYCS binds APIP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44175", "l": "H2O + NAD(+) + tetradecanal <=> 2 H(+) + NADH + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788999", "l": "HV1-mediated H+ transfer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48505", "l": "D-glycero-D-manno-heptose 1,7-bisphosphate + H2O => D-glycero-D-manno-heptose 1-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31300", "l": "H2O + NAD(+) + perillyl aldehyde => 2 H(+) + NADH + perillate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68954", "l": "Mcm2-7 is phosphorylated by DDK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30611", "l": "A + all-trans-zeta-carotene = AH2 + all-trans-neurosporene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53668", "l": "(2E,6E)-farnesyl diphosphate = (1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate"}, {"i": "EC:4.2.3.165", "l": "\"(1R,4R,5S)-(-)-guaia-6,10(14)-diene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211960", "l": "CYP2U1 19-hydroxylates ARA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43847", "l": "(3beta)-hydroxy-cholest-5-en-26-al + NADPH + O2 <=> (3beta)-hydroxy-cholest-5-en-26-oate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28113", "l": "chloride + S-adenosyl-L-methionine <=> 5'-chloro-5'-deoxyadenosine + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11176", "l": "2-alpha-D-glucosyl-D-glucose + phosphate = beta-D-glucose 1-phosphate + D-glucose"}, {"i": "EC:2.4.1.230", "l": "\"Kojibiose phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951676", "l": "RUNX3 binds TEADs and YAP1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16054", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosamine => H(+) + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52612", "l": "3-(methylsulfanyl)propanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 3-(methylsulfanyl)acryloyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374680", "l": "L1 trans-homophilic interaction (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008031", "l": "eclosion hormone activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878237", "l": "RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46578", "l": "2 H2O + NADP(+) + stigmasterol => (24R)-ethylcholest-5-en-3beta-ol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216048", "l": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36967", "l": "(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32503", "l": "linalool + O2 + reduced [NADPH--hemoprotein reductase] = (6E)-8-hydroxylinalool + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112037", "l": "Inactivation of PLC beta (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39467", "l": "(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + NADPH = (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51679", "l": "[protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide <=> [protein]-dithiol + 2 AH2 + H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417829", "l": "P2RY12 binds ADP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61316", "l": "germacra-1(10),4,11(13)-trien-12-al + O2 + reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55212", "l": "(2R)-hydroxyhexadecanoyl-CoA = formyl-CoA + pentadecanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29957", "l": "H(+)(out) + thymidine(out) => H(+)(in) + thymidine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26310", "l": "1,4-dihydroxy-2-naphthoyl-CoA + H2O => 1,4-dihydroxy-2-naphthoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63155", "l": "an N-fatty acyl-taurine + H2O <=> a fatty acid + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17496", "l": "A + glycerol <=> AH2 + dihydroxyacetone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690669", "l": "CD22 binds itself to form homo-oligomers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13715", "l": "a ubiquinol + fumarate => a ubiquinone + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2534365", "l": "Slo3 Potassium Transport (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665727", "l": "FMNL2 binds CDC42:GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32929", "l": "a 1,2-diacyl-sn-glycerol + H(+) + sn-glycerol 3-phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9611277", "l": "P2RY12 binds P2RY12 antagonists (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35028", "l": "ATP + H2O + tungstate(in) => ADP + H(+) + phosphate + tungstate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42398", "l": "2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine => cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52093", "l": "5-(9Z-hexadecenoyloxy)-octadecanoate + H2O => (9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22129", "l": "(1S,2R,4S)-borneol + NAD(+) => (1S,4S)-camphor + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22553", "l": "3'-phosphoadenylyl sulfate + an alcohol => adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11410", "l": "lumichrome + ribitol => H(+) + H2O + riboflavin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10984", "l": "(S)-lactate + oxaloacetate = (S)-malate + pyruvate"}, {"i": "EC:1.1.99.7", "l": "\"Lactate--malate transhydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14420", "l": "acetyl phosphate + L-lysine <=> H(+) + N(6)-acetyl-L-lysine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14546", "l": "H2O + nicotinamide => NH4(+) + nicotinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210282", "l": "Interaction of GPVI and FceRI gamma (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11255", "l": "H(+) + hydroxylamine + L-asparagine <=> beta-L-aspartylhydroxamate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047232", "l": "galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,6-N-acetylglucosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56020", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2) = beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25443", "l": "(2E,6E)-farnesyl diphosphate <=> delta-selinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30718", "l": "(2E)-geraniol <=> (S)-linalool"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432544", "l": "Phosphorylated PER transports from the cytosol to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50495", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37553", "l": "2-oxoglutarate + D-kanosamine 6-phosphate => 3-dehydro-D-glucose 6-phosphate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102462", "l": "quercetin 3-sophoroside 7-O-rhamnosyltransferase activity"}, {"i": "MetaCyc:RXN-14011"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482770", "l": "Release of platelet secretory granule components (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44337", "l": "an L-alpha-amino acid + ATP + L-arginine => ADP + H(+) + L-arginyl-L-alpha-amino acid + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9664879", "l": "ATM:PEX5 binds ATM (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11683", "l": "ATP + H2O + L-glutamine + XMP <=> AMP + diphosphate + GMP + 2 H(+) + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218836", "l": "PTK2beta binds alphaVbeta3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67034", "l": "4,5,8-trihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4,8-dihydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38276", "l": "(3R)-citramalyl-CoA => acetyl-CoA + pyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043287", "l": "poly(3-hydroxyalkanoate) binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36814", "l": "acetyl-CoA + GDP-alpha-D-perosamine <=> CoA + GDP-N-acetyl-alpha-D-perosamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35731", "l": "sn-glycerol 3-phosphate + tetradecanoyl-CoA = 1-tetradecanoyl-sn-glycerol 3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2314678", "l": "Aspirin acetylates PTGS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5082356", "l": "HSF1-mediated gene expression (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57764", "l": "2,6-dinitrotoluene + NADH + O2 = 3-methyl-4-nitrocatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10899", "l": "2 H2O + limonin <=> 2 H(+) + limonoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66985", "l": "3-methylbutanoyl-CoA + H2O => CoA + H(+) + isovalerate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029471", "l": "Hydrolysis of PC to PA by PLD (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58198", "l": "acetate + L-lysyl-[histone] => H2O + N(6)-acetyl-L-lysyl-[histone]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66917", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 9-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186798", "l": "GAP binds to PDGF-beta receptors only (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39057", "l": "22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002162", "l": "dystroglycan binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853793", "l": "p-5Y-RET complexes bind GRB2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430158", "l": "p-SLP-76 binds VAV (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13535", "l": "(3R)-vestitone + H(+) + NADPH => H2O + medicarpin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41052", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + tetradecanoyl-CoA => 1,2-di-(9Z)-octadecenoyl-3-tetradecanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008193", "l": "tRNA guanylyltransferase activity"}, {"i": "RHEA:54564", "l": "5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O = a 5'-phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)"}, {"i": "EC:2.7.7.79", "l": "\"tRNA(His) guanylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190261", "l": "FGFR3c binds to FGF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50543", "l": "prostaglandin A2 <=> prostaglandin C2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27798", "l": "(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = all-trans-octaprenyl diphosphate + 5 diphosphate"}, {"i": "EC:2.5.1.90", "l": "\"All-trans-octaprenyl-diphosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2317314", "l": "AKT binds PDPK1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65402", "l": "butyl butanoate + CoA => butan-1-ol + butanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873917", "l": "Translocation of STAT1 dimer to nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64840", "l": "2-phenylethanol + benzoyl-CoA = CoA + phenethyl benzoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62533", "l": "2 [Fe(II)cytochrome c] + digitoxin + 3 H(+) => 2 [Fe(III)cytochrome c] + dihydrodigitoxin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004805", "l": "trehalose-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "72.105362717182985", "identifiers": [{"i": "GO:0015079", "l": "potassium ion transmembrane transporter activity"}, {"i": "RHEA:29463", "l": "K(+)(in) = K(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15006", "l": "2-oxoglutarate + gibberellin A1 + O2 => CO2 + gibberellin A8 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44915", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH <=> (3E)-hexenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45487", "l": "H(+) + pyruvate <=> acetaldehyde + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26385", "l": "all-trans-8'-apo-beta-carotenal + O2 = (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal"}, {"i": "EC:1.13.11.75", "l": "\"All-trans-8'-apo-beta-carotenal 15,15'-oxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38229", "l": "CoA + hexadecanyl (9Z)-octadecenoate => (9Z)-octadecenoyl-CoA + hexadecan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58999", "l": "H2O + indole-3-carbaldehyde + O2 <=> H(+) + H2O2 + indole-3-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65184", "l": "2-oxoglutarate + O2 + preaustinoid A1 = berkeleyone B + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57780", "l": "2-chloro-4-nitrotoluene + NADH + O2 = 3-chloro-4-methylcatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59688", "l": "D-maltoheptaose + O2 = D-maltoheptaono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004615", "l": "phosphomannomutase activity"}, {"i": "MetaCyc:PHOSMANMUT-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647746", "l": "EML4 trimerizes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51203", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-retinylidene-N-retinylethanolamine <=> H2O + N-retinylidene-N-retinylphosphatidylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694677", "l": "ZCRB1 binds 5'UTR of SARS-CoV-2 genomic RNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9690493", "l": "RHOB binds effectors on endosomes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948709", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173739", "l": "Spontaneous hydrolysis of C3 thioester (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674018", "l": "BRAP binds RAS:GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25147", "l": "(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde = H(+) + H2O + quinolinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805640", "l": "AKT phosphorylates KAT6A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785594", "l": "FANCD2 binds FANCI (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086223", "l": "Collagen type IX binds integrin alpha11beta1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74723", "l": "Endosome acidification (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005199", "l": "structural constituent of cell wall"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102873", "l": "1-18:1-2-16:0-digalactosyldiacylglycerol desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50154", "l": "15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O => (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103068", "l": "leukotriene C4 gamma-glutamyl transferase activity"}, {"i": "MetaCyc:RXN66-336"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54219", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 <=> 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16276", "l": "an N-acylsphing-4-enine + CDP-choline <=> a sphingomyelin + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52384", "l": "L-glutamate + O-phospho-L-serine = H(+) + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate"}, {"i": "EC:2.5.1.140", "l": "\"N-(2-amino-2-carboxyethyl)-L-glutamate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63539", "l": "[des-Arg(9)]-bradykinin + H2O <=> [des-Phe(8), des-Arg(9)]-bradykinin + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164423", "l": "PhosphoChREBP (Thr 666)  is exported to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29049", "l": "a menaquinol + 2 H(+)(out) => a menaquinone + 2 H(+)(in) + H2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13744", "l": "3-phenylpyruvate + L-tryptophan <=> indole-3-pyruvate + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617941", "l": "Expression of superoxide dismutase 2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612076", "l": "p-4S, T366 ELK1:SRF bind EGR1 and EGR2 gene promoters (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1470010", "l": "Dimerization of STATs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58193", "l": "dimethylallyl diphosphate + H2O + isopentenyldehydrorhodopin => dihydrobisanhydrobacterioruberin + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043748", "l": "O-succinylbenzoate synthase activity"}, {"i": "RHEA:10196", "l": "(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O"}, {"i": "EC:4.2.1.113", "l": "\"o-succinylbenzoate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3858482", "l": "DVL is recruited to the receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45748", "l": "(3Z)-hexenoyl-CoA = (2E)-hexenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-178215", "l": "SMAD7:SMURF1 complex is exported to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57001", "l": "acetyl-CoA + streptothricin F => CoA + H(+) + N(beta)-acetylstreptothricin F"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27507", "l": "cocaine + H2O => benzoate + ecgonine methyl ester + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048270", "l": "methionine adenosyltransferase regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51767", "l": "dimethylallyl diphosphate + phlorisovalerophenone <=> 4-prenylphlorisovalerophenone + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050170", "l": "peptidyl-glutaminase activity"}, {"i": "RHEA:10032", "l": "[protein]-C-terminal-L-glutamine + H2O = [protein]-C-terminal-L-glutamate + NH4(+)"}, {"i": "EC:3.5.1.43", "l": "\"Peptidyl-glutaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34405", "l": "(2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal + carlactone => 9-cis-10'-apo-beta-carotenal + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29338", "l": "H2O + L-alanyl-L-glutamate <=> L-alanine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296127", "l": "Activation of voltage gated Potassium channels (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676596", "l": "TRAF3 binds BAFFR:BAFF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48063", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H2O <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10454", "l": "(R)-dihydrocamalexate + 2 H(+) + 2 H2O + hydrogen cyanide + oxidized [NADPH--hemoprotein reductase] => 2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43546", "l": "ADP + gamma-L-glutamyltyramine + H(+) + phosphate => ATP + L-glutamate + tyramine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39361", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+) => (13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174438", "l": "Formation of the Flap Intermediate on the C-strand (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34402", "l": "9-cis-beta-carotene + O2 <=> 9-cis-10'-apo-beta-carotenal + beta-ionone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52082", "l": "12-hydroxyoctadecanoate + H(+) + octadecanoate => 12-octadecanoyloxy-octadecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983142", "l": "Formation of peptide loading complex (PLC) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015199", "l": "amino-acid betaine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0051861", "l": "glycolipid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607733", "l": "BCL10 binds CARD9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35518", "l": "4'''-demalonylsalvianin + malonyl-CoA <=> CoA + salvianin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24162", "l": "D-galacto-hexodialdose + H2O2 => D-galactose + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41915", "l": "(2E)-hexadecenoyl-[ACP] + H(+) + NADPH <=> hexadecanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.15"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37981", "l": "2,3-dimethyl-6-phytylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine => 2-methyl-6-phytyl-1,4-benzene-1,4-diol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625574", "l": "Defective SLC22A18 does not exchange extracellular organic cations for cytosolic H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51381", "l": "(9Z)-octadecenoyl-CoA + dopamine => CoA + H(+) + N-(9Z-octadecanoyl)-dopamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806613", "l": "Keratin tetramers bind to form unit length filaments (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41605", "l": "1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905575", "l": "ganglioside GM3 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15216", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA <=> (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2299620", "l": "Collagen XI cross-links with collagen II (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29800", "l": "ATP + D-allose(out) + H2O => ADP + D-allose(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18373", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)"}, {"i": "EC:2.7.1.154", "l": "\"Phosphatidylinositol-4-phosphate 3-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41167", "l": "a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043817", "l": "phosphosulfolactate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51985", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052754", "l": "GTP:coenzyme F420 guanyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32784", "l": "ATP + glycine betaine(out) + H2O => ADP + glycine betaine(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981832", "l": "NMUR2 binds neuromedin-S (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52103", "l": "5-(9Z-octadecenoyloxy)-octadecanoate + H2O <=> (9Z)-octadecenoate + 5-hydroxy-octadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15264", "l": "5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> 5beta-cholestane-3alpha,7alpha,12alpha-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20510", "l": "ATP + viomycin => ADP + H(+) + O-phosphoviomycin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2430535", "l": "MASTL phosphorylates ENSA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685838", "l": "CX3 complex binds D-loop structures (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13795", "l": "2-methylene-3-methylsuccinate => 2-methyleneglutarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804762", "l": "TP53 forms homotetramers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51600", "l": "2 H(+) + m-xylene + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.15.26", "l": "\"Toluene methyl-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11477", "l": "glycerol 1-phosphate + H2O => glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14140", "l": "3'-phosphoadenylyl sulfate + beta-D-galactosyl-(1<->1)-sphing-4-enine <=> 6-O-sulfo-beta-D-galactosyl-(1<->1)-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354124", "l": "Phosphorylation of pPTK2 by SRC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24184", "l": "4,5-dihydroxyphthalate + H(+) = 3,4-dihydroxybenzoate + CO2"}, {"i": "EC:4.1.1.55", "l": "\"4,5-dihydroxyphthalate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34796", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O => alpha-D-ribose 1,5-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23668", "l": "apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin = AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase]"}, {"i": "EC:6.3.4.9", "l": "\"Biotin--[methylmalonyl-CoA-carboxytransferase] ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39938", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.98.-", "l": "\"With other, known, acceptors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56127", "l": "A + all-trans-lycopene + dimethylallyl diphosphate + H2O <=> AH2 + diphosphate + nonaflavuxanthin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003879", "l": "ATP phosphoribosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52576", "l": "hexanoyl-CoA + NAD(+) = (2E)-hexenoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26558", "l": "(3S)-3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53914", "l": "CoA + H(+) + N(6)-butanoyl-L-lysyl-[protein] => butanoyl-CoA + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614591", "l": "Excess cysteine yields lanthionine and H2S (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37722", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141159", "l": "TNF-mediated dimerization of procaspase-8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977228", "l": "Sialyltransferase I can add sialic acid to the T antigen at the alpha 6 position (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58481", "l": "a cytidine in mRNA + acetyl-CoA + ATP + H2O => ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34634", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced [adrenodoxin] <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351871", "l": "Caspase-mediated cleavage of Z0-2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667761", "l": "KCNMA1:KCNMB1:LRRC52 transports K+ from the cytosol to the extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50628", "l": "a 2-(omega-methylsulfanyl)alkylmalate = a 3-(omega-methylsulfanyl)alkylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32475", "l": "glycine + 3 S-adenosyl-L-methionine = glycine betaine + 3 H(+) + 3 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.162", "l": "\"Glycine/sarcosine/dimethylglycine N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380177", "l": "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106157", "l": "peptidyl-arginine 3-dioxygenase activity"}, {"i": "RHEA:56744", "l": "2-oxoglutarate + L-arginyl-[protein] + O2 = (3R)-3-hydroxy-L-arginyl-[protein] + CO2 + succinate"}, {"i": "EC:1.14.11.73", "l": "\"[Protein]-arginine 3-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69127", "l": "Formation of the Flap Intermediate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804100", "l": "HMGB1 binds LPS (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28494", "l": "a menaquinone + dimethyl sulfide + H2O = a menaquinol + dimethyl sulfoxide"}, {"i": "EC:1.8.5.3", "l": "\"Respiratory dimethylsulfoxide reductase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019180", "l": "dTDP-4-amino-4,6-dideoxygalactose transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649856", "l": "Oxidative damage to the AP site (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1067667", "l": "IL6 binds IL6R (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0032554", "l": "purine deoxyribonucleotide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23528", "l": "citramalate + succinyl-CoA = citramalyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028519", "l": "NTRK2-activated PI3K generates PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031220", "l": "maltodextrin phosphorylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42452", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate = H2O + kynurenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37530", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59476", "l": "2 AH2 + 2 ATP + benzoate + L-phenylalanine = 2 A + 2 AMP + 2 diphosphate + H(+) + N-benzoyl-L-phenylalaninol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168930", "l": "Viral dsRNA:TLR3:TRIF complex recruits RIP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23179", "l": "acetate + ATP + CoA <=> acetyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53120", "l": "(3beta,5alpha,17beta)-3-hydroxyandrostan-17-yl sulfate + NADP(+) = 5alpha-dihydrotestosterone sulfate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050139", "l": "nicotinate-N-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39214", "l": "(3R)-hydroxyhexacosanoyl-CoA <=> (2E)-hexacosenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15211", "l": "2-hydroxy-3-oxosuccinate + H(+) + NADH => (2R,3R)-tartrate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030372", "l": "high molecular weight B cell growth factor receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59251", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + (E)-4-coumaroyl-CoA <=> (E)-4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22372", "l": "H2O + O2 + propionate 3-nitronate = 3-oxopropanoate + H(+) + H2O2 + nitrite"}, {"i": "EC:1.7.3.5", "l": "\"3-aci-nitropropanoate oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102867", "l": "molybdenum cofactor sulfurtransferase activity"}, {"i": "RHEA:42636", "l": "AH2 + L-cysteine + Mo-molybdopterin = A + H2O + L-alanine + thio-Mo-molybdopterin"}, {"i": "EC:2.8.1.9", "l": "\"Molybdenum cofactor sulfurtransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168887", "l": "Ferriheme is transferred from Albumin to Hemopexin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "81.790986234327661", "identifiers": [{"i": "GO:0016657", "l": "oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor"}, {"i": "EC:1.6.6.-", "l": "\"With a nitrogenous group as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033957", "l": "lambda-carrageenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50923", "l": "2 2-iminio-3-(indol-3-yl)propanoate + H2O2 <=> chromopyrrolate + H(+) + 2 H2O + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9619376", "l": "CAMK1 binds calmodulin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20035", "l": "penicillin N => isopenicillin N"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047994", "l": "hydroxymethylglutaryl-CoA hydrolase activity"}, {"i": "RHEA:16305", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944262", "l": "Association of procollagen type X (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41244", "l": "N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine => N-acyl-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoate (4E)-octadecasphin-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76052", "l": "Binding of TFIIIA To type 1 Promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70613", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15230", "l": "alpha-D-mannose 1-phosphate + GTP + H(+) => diphosphate + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685605", "l": "SLAMF7 binds SLAMF7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005159", "l": "insulin-like growth factor receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14565", "l": "(11Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(13Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045509", "l": "interleukin-27 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59418", "l": "H2O2 + indole-3-acetaldehyde + NH4(+) => H2O + O2 + tryptamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61724", "l": "a D-glucoside + NAD(+) = a 3-dehydro-D-glucoside + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54460", "l": "1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676229", "l": "WIPIs bind PI3P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52100", "l": "5-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 5-hydroxy-octadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45557", "l": "H2O + N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-dodecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416683", "l": "SEMA3E binds to PLXND1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008418", "l": "protein-N-terminal asparagine amidohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72631", "l": "Formation of the cap-binding eIF4F complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53293", "l": "H2O + L-5-[2-(methysulfanyl)ethyl]hydantoin => H(+) + N-carbamoyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018785", "l": "RHOBTB2 binds GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169891", "l": "ARMS:Crk complex binds to active TrkA receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194678", "l": "CYP51A1 demethylates LNSOL (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50161", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 => N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52951", "l": "deoxycholate + UDP-alpha-D-glucuronate <=> deoxycholoyl-24-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419644", "l": "Transphosphorylation of pLIMK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61937", "l": "ATP + cycloheximide(in) + H2O => ADP + cycloheximide(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30833", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-hex-4-ulose => UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53767", "l": "allocholate + lithocholoyl-CoA <=> allocholoyl-CoA + lithocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866304", "l": "pre-VLDL binds lipids to form VLDL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026912", "l": "GGT hydrolyses PCTR1 to PCTR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981931", "l": "RAC1 and CDC42 activate PAK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67024", "l": "a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine = a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.296", "l": "\"Methyltransferase cap2\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53103", "l": "2-hydroxyestrone + S-adenosyl-L-methionine <=> 2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41226", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-383190", "l": "HCO3- transport through ion channel (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373075", "l": "Metabotropic glutamate receptors bind glutamate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61338", "l": "ADP + H(+) + phosphate + protoporphyrin IX(out) => ATP + H2O + protoporphyrin IX(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29297", "l": "aldehydo-D-galacturonate(in) + H(+)(in) => aldehydo-D-galacturonate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71825", "l": "G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37376", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806413", "l": "TP53 binds the MLH1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941701", "l": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42586", "l": "1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51802", "l": "adlupulone + diphosphate + H(+) => deoxyadlupulone + dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55926", "l": "albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => albendazole + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49017", "l": "aurachin C epoxide => 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55317", "l": "3 H2O + hydrogen sulfide + 3 NAD(+) => 4 H(+) + 3 NADH + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33425", "l": "diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein] => N(pros)-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-437139", "l": "ZnT6 transports zinc into the golgi apparatus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44381", "l": "a 3-demethylubiquinol + S-adenosyl-L-methionine => a ubiquinol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36837", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37546", "l": "2-amino-5-chlorophenol + O2 <=> 2-amino-5-chloromuconate 6-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24124", "l": "all-trans-retinal = 11-cis-retinal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399711", "l": "Activation of Ca impermeable AMPA receptors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15306", "l": "betaine aldehyde + H2O + NAD(+) => glycine betaine + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227863", "l": "Recruitment of IRF to activated TBK1/IKK epsilon (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730841", "l": "Phosphorylation and activation of VAV (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40986", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O <=> (9Z)-octadecenoate + 1,3-dihexadecanoylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694527", "l": "Loss of SAR1B GTPase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53969", "l": "apo-[BtrI ACP] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[BtrI ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63115", "l": "A + ascofuranol <=> AH2 + ascofuranone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202164", "l": "Translocation of PDK1 to Plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37446", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9669854", "l": "KIT binds type II TKIs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028724", "l": "AMOT proteins bind YAP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42516", "l": "H2O + L-gulono-1,4-lactone = H(+) + L-gulonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11006", "l": "catechol + CO2 + H2O + NAD(+) => 2 H(+) + NADH + O2 + salicylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444705", "l": "T1R1/T1R3 dimer is the umami taste receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177479", "l": "Axonal transport of NGF:Trk complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102080", "l": "phenylacetyl-coenzyme A:glycine N-acyltransferase activity"}, {"i": "MetaCyc:RXN-10821"}]}
{"type": "biolink:MolecularActivity", "ic": "71.045893708194711", "identifiers": [{"i": "GO:0016651", "l": "oxidoreductase activity, acting on NAD(P)H"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71495", "l": "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25155", "l": "2-oxoglutarate + L-phenylalanine <=> 3-phenylpyruvate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001079", "l": "beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29717", "l": "FMN + glycolaldehyde + 2 H(+) + H2O + sulfite => 2-hydroxyethane-1-sulfonate + FMNH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950504", "l": "IL27 binds CRLF1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65679", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontadienoyl)-sphing-4-enine <=> a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontadienoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38899", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034793", "l": "cyclopropanecarboxylate-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19910", "l": "(S)-lactate + 2 [Fe(III)cytochrome c] => 2 [Fe(II)cytochrome c] + 2 H(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624798", "l": "LBR binds KPNB1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050203", "l": "oxalate-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247837", "l": "WNT ligands traffic to the Golgi (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55287", "l": "all-trans-retinol + tetradecanoyl-CoA <=> all-trans-retinyl tetradecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404200", "l": "IGF1,2 binds IGF1R (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956026", "l": "CUL9:RBX1 ubiquitinates BIRC5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53427", "l": "a fatty acyl-CoA + a sphingoid base <=> an N-acyl-sphingoid base + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20787", "l": "H2O + N(omega)-(ADP-D-ribosyl)-L-arginine <=> ADP-D-ribose + L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189062", "l": "lactose + H2O => D-glucose + D-galactose (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655760", "l": "Defective SLC40A1 does not transport Fe3+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141341", "l": "SMOX-3 oxidises SPN to SPM (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48705", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => 12S-HpEPE"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045152", "l": "antisigma factor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856157", "l": "LAG3 (CD233) binds MHC II (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015224", "l": "biopterin transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2530573", "l": "CREG(CR1L) binds to surface-bound C3 convertases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29870", "l": "AMP + ITP <=> ADP + IDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176445", "l": "SMURF2 binds SMAD2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63651", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.4.3", "l": "\"L-arginine:L-lysine amidinotransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043728", "l": "2-keto-4-methylthiobutyrate aminotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37402", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine <=> 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65654", "l": "a diacylglycerol + N-(32-(9Z,12Z-octadecadienoyloxy)-dotricontanoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontanoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982017", "l": "Active G alpha (q) binds RGS proteins (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63891", "l": "hexadecanoyl-CoA + sphinga-4E,14Z-dienine <=> CoA + H(+) + N-hexadecanoyl-sphinga-4E,14Z-dienine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33657", "l": "(9Z)-octadecenoate(in) => (9Z)-octadecenoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9674531", "l": "AAMP binds EGFR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862380", "l": "HSD17B13 binds lipid droplets (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13928", "l": "(3R)-hydroxytetradecanoyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine <=> holo-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047846", "l": "deoxynucleotide 3'-phosphatase activity"}, {"i": "RHEA:10092", "l": "a 2'-deoxyribonucleoside 3'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate"}, {"i": "EC:3.1.3.34", "l": "\"Deoxynucleotide 3'-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849878", "l": "PSD-95 binds NMDA receptor (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021450", "l": "PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53631", "l": "(2E,6E)-farnesyl diphosphate <=> (2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781899", "l": "USP13 binds SIAH2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57620", "l": "dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50734", "l": "(S)-4-hydroxymandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4-hydroxyphenylacetonitrile + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20221", "l": "(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate"}, {"i": "EC:6.3.4.3", "l": "\"Formate--tetrahydrofolate ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16339", "l": "a 3'-hydroxyflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 3'-unsubstituted flavone + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626235", "l": "HSPA8 dissociates from LAMP2a (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10128", "l": "all-trans-violaxanthin = all-trans-neoxanthin"}, {"i": "EC:5.3.99.9", "l": "\"Neoxanthin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53225", "l": "16alpha,17alpha-dihydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] => 3beta,16alpha-dihydroxy-androst-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168459", "l": "Lyn activates ERK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34075", "l": "an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate"}, {"i": "EC:2.3.1.275", "l": "\"Acyl phosphate:glycerol-3-phosphate acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38703", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11532", "l": "glycine + H2O + O2 = glyoxylate + H2O2 + NH4(+)"}, {"i": "EC:1.4.3.19", "l": "\"Glycine oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2399913", "l": "atRAL binds to RBP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15849", "l": "2 [Fe(III)cytochrome c] + L-ascorbate = 2 [Fe(II)cytochrome c] + 2 H(+) + L-dehydroascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29728", "l": "ethane-1-sulfonate + FMNH2 + O2 => acetaldehyde + FMN + 2 H(+) + H2O + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17135", "l": "ADP + H(+) + O-phospho-L-seryl-[tyrosine-3-monooxygenase] => ATP + L-seryl-[tyrosine-3-monooxygenase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41664", "l": "dihydrochelirubine + NAD(+) = chelirubine + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32549", "l": "(1R,5R)-sabinene + diphosphate => (2E)-geranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31001", "l": "cucurbitadienol => (S)-2,3-epoxysqualene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10730", "l": "GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH => GDP-6-deoxy-alpha-D-talose + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473594", "l": "Collagen type II degradation by MMP15 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10616", "l": "(2R,3S)-catechin + H2O + NADP(+) = (2R,3S,4S)-leucocyanidin + H(+) + NADPH"}, {"i": "EC:1.17.1.3", "l": "\"Leucoanthocyanidin reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24168", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66013", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + hypobromite + L-methionyl-[collagen] => [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54270", "l": "(3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha subunit] + CO2 + succinate => 2-oxoglutarate + L-asparaginyl-[hypoxia-inducible factor alpha subunit] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008949", "l": "oxalyl-CoA decarboxylase activity"}, {"i": "RHEA:19333", "l": "H(+) + oxalyl-CoA = CO2 + formyl-CoA"}, {"i": "EC:4.1.1.8", "l": "\"Oxalyl-CoA decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58692", "l": "FADH2-C4alpha-hydroperoxide + H(+) + NADH + rifamycin SV = FADH2 + H2O + NAD(+) + rifamycin SV hemiaminal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664879", "l": "ATM:PEX5 binds ATM (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603548", "l": "NTRK3(496-641) binds NELFB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14606", "l": "D-glucose 6-phosphate + GDP-alpha-D-glucose => alpha,alpha-trehalose 6-phosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47248", "l": "2 [Fe(III)cytochrome c] + L-gulono-1,4-lactone = 2 [Fe(II)cytochrome c] + 3 H(+) + L-ascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30667", "l": "germacra-1(10),4,11(13)-trien-12-ol + H2O + 2 NADP(+) = germacra-1(10),4,11(13)-trien-12-oate + 3 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32355", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + 2 UDP-alpha-D-glucose = 2 H(+) + ternatin C5 + 2 UDP"}, {"i": "EC:2.4.1.249", "l": "\"Delphinidin 3',5'-O-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12238", "l": "6-hydroxynicotinate + H(+) + NADPH => H2O + NADP(+) + nicotinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53973", "l": "(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29729", "l": "acetaldehyde + FMN + 2 H(+) + H2O + sulfite => ethane-1-sulfonate + FMNH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9006870", "l": "IL21 receptor STAT phosphorylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8944457", "l": "MAF1 translocates to the nucleus (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44896", "l": "a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose = H(+) + N-(2-hydroxyacyl)-beta-D-galactosyl-sphing-4-enine + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6805811", "l": "Release of SEPT4 from mitochondria (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54085", "l": "7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine => archaeosine(15) in tRNA + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66562", "l": "5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+) => (R)-noradrenaline + L-glutaminyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295632", "l": "PPA2A dephosphorylates SPRY2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416358", "l": "G alpha (q) inhibits PI3K alpha (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937613", "l": "CRHBP binds CRH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201629", "l": "Caspase-mediated cleavage of Tau (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0016429", "l": "tRNA (adenine-N1-)-methyltransferase activity"}, {"i": "REACT:R-HSA-6787594", "l": "TRMT10C:HSD17B10 (TRMT10C:SDR5C1) methylates adenosine-9 in tRNA yielding 1-methyladenosine-9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12632", "l": "2-oxoglutarate + L-hyoscyamine + O2 <=> (6S)-6-hydroxyhyoscyamine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627107", "l": "XIAP binds CASP7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40939", "l": "1-O-hexadecylglycerone 3-phosphate + H(+) + NADPH = 1-O-hexadecyl-sn-glycero-3-phosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034899", "l": "trimethylamine monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-190141", "l": "ALAD binds to Pb2+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052924", "l": "all-trans-nonaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296045", "l": "Activation of Potassium transport channels (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39995", "l": "an N-acylethanolamine + H2O = a fatty acid + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45853", "l": "Co(II)-factor III + H(+) + S-adenosyl-L-methionine => Co(II)-factor IV + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60909", "l": "a cytidine in tRNA + S-adenosyl-L-methionine => an N(3)-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626223", "l": "C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865994", "l": "GAB1 binds PTPN11 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211224", "l": "Association of DFF40 with DFF45 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807565", "l": "GNLY is transferred to the phagosome (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34934", "l": "glutathioselenol + NADPH <=> glutathione + hydrogenselenide + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187746", "l": "RIT/RIN are activated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73757", "l": "Binding of RRN3 to RNA Polymerase I (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57577", "l": "7-deoxyloganate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + loganate + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29755", "l": "(R)-lipoate(in) = (R)-lipoate(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097604", "l": "temperature-gated cation channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54214", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphocholine => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65359", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + ATP <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28017", "l": "S-adenosyl-L-methionine + thiocyanate <=> methyl thiocyanate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964759", "l": "Alternative endo-mannosidase I route (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44974", "l": "CoA + O-hexanoyl-(R)-carnitine => (R)-carnitine + hexanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34675", "l": "CTP + N,N-diacetyllegionaminate = CMP-N,N-diacetyllegionaminate + diphosphate"}, {"i": "EC:2.7.7.82", "l": "\"CMP-N,N'-diacetyllegionaminic acid synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20034", "l": "isopenicillin N => penicillin N"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55838", "l": "calcitriol 25-O-(beta-D-glucuronide) + H(+) + UDP => calcitriol + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65505", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + H2O => 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + [mycofactocin precursor peptide]-C-terminal glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10889", "l": "4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H2O + NADP(+) => 4-carboxy-2-hydroxy-cis,cis-muconate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17362", "l": "3-oxo-3-ureidopropanoate + H2O => H(+) + malonate + urea"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047609", "l": "acetylputrescine deacetylase activity"}, {"i": "RHEA:23412", "l": "H2O + N-acetylputrescine = acetate + putrescine"}, {"i": "EC:3.5.1.62", "l": "\"Acetylputrescine deacetylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809010", "l": "COPI vesicle uncoating (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29861", "l": "5-deoxy-D-ribose + adenine => 5'-deoxyadenosine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852317", "l": "PLK1 phosphorylates GTSE1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45868", "l": "9-decenoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(non-8-en-1-yl)-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029473", "l": "Branching and elongation of mother and daughter filaments (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.2.1.11", "l": "\"6-deoxy-5-ketofructose 1-phosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61687", "l": "glycero-2-phosphocholine + H2O <=> glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381435", "l": "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5660980", "l": "p-S276-RELA binds RELB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35211", "l": "dIDP + H2O = dIMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56445", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18150", "l": "H2O + N-acetyl-D-galactosamine 6-phosphate => acetate + D-galactosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046905", "l": "15-cis-phytoene synthase activity"}, {"i": "RHEA:34479", "l": "(1R,2R,3R)-prephytoene diphosphate = 15-cis-phytoene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675206", "l": "PEA15 binds MAPK monomers and dimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683792", "l": "p-T68-CHEK2 autophosphorylates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33545", "l": "ergosterol + H(+) + hexadecanoate => ergosteryl palmitate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65515", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + O2 <=> 5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18563", "l": "4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004807", "l": "triose-phosphate isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51271", "l": "norbelladine + S-adenosyl-L-methionine <=> 4'-O-methylnorbelladine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57467", "l": "(E)-caffeate + UDP-alpha-D-glucose <=> 1-O-[(E)-caffeoyl]-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67159", "l": "1-O-(1Z-hexadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49242", "l": "L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in) => N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15731", "l": "H(+) + keto-D-fructuronate + NADH => D-mannonate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.17.2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019150", "l": "D-ribulokinase activity"}, {"i": "EC:2.7.1.47", "l": "\"D-ribulokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65139", "l": "(9Z)-octadecenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000109", "l": "CD320:TCII:Cbl dissociates into CD320 and TCII:Cbl (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209823", "l": "Tyrosine is hydroxylated to dopa (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25663", "l": "(2E)-geranyl diphosphate => alpha-pinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44405", "l": "3-demethylubiquinol-7 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23747", "l": "2-oxoglutarate + L-histidinol phosphate <=> 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29691", "l": "alpha-maltotetraose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltotriose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57745", "l": "[protein]-disulfide + phylloquinol => [protein]-dithiol + phylloquinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362386", "l": "Glycosylation of Hh (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58306", "l": "25-substituted-cholesteryl beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine => 25-substituted-cholesterol + beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27378", "l": "(R)-glycerate + ATP => (2R)-2-phosphoglycerate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140691", "l": "RNA folding chaperone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878013", "l": "RUNX2 and SMAD1 complex binds the SMAD6 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11971", "l": "AH2 + kynurenate + O2 <=> 7,8-dihydro-7,8-dihydroxykynurenate + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47453", "l": "(2E,5Z)-tetradecadienoyl-CoA + H2O => (3S)-hydroxy-(5Z-tetradecenoyl)-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57510", "l": "(2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate => H2O + NADP(+) + staphylopine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264997", "l": "Oxidation of cysteine to cystine in Proinsulin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49191", "l": "a bacteriochlorophyllide d <=> a 3-vinylbacteriochlorophyllide d + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050697", "l": "1,1,2-trichloroethene reductive dehalogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1470010", "l": "Dimerization of STATs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10637", "l": "D-mannonate + NADP(+) => D-mannuronate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1458463", "l": "p-AKT2 phosphorylates RGC2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17377", "l": "dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+)"}, {"i": "RHEA:53396", "l": "dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+)"}, {"i": "EC:2.4.1.109", "l": "\"Dolichyl-phosphate-mannose--protein mannosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36271", "l": "caffeine + H(+) + NADPH + O2 = formaldehyde + H2O + NADP(+) + theobromine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38869", "l": "pseudouridine(516) in 16S rRNA => uridine(516) in 16S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508513", "l": "PTK2B binds JAK3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30577", "l": "3 menaquinol-8 + protoporphyrin IX => 3 menaquinone-8 + protoporphyrinogen IX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53924", "l": "a secondary amine + S-adenosyl-L-methionine = a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73797", "l": "FAICAR => IMP + H2O (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52886", "l": "2 H(+) + 2 NADPH + nitrobenzene => H2O + N-phenylhydroxylamine + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28984", "l": "nitrite(in) => nitrite(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65127", "l": "benzoyl-CoA + ethanol <=> benzyl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19119", "l": "(R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical => dopamine + 2 L-ascorbate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202966", "l": "Caspase mediated cleavage of HIP-55 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062069", "l": "GARP complex binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050470", "l": "trimethylamine dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25458", "l": "diphosphate + gamma-humulene => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56047", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034901", "l": "endosulfan hydroxyether dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23797", "l": "17-O-acetylnorajmaline + H2O => acetate + H(+) + norajmaline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.2.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48635", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate <=> 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33006", "l": "(+)-amorpha-4,11-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-artemisinic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31010", "l": "(S)-2,3-epoxysqualene <=> beta-amyrin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63703", "l": "mycophenolate + UDP-alpha-D-glucuronate <=> mycophenolic acid O-acyl-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668831", "l": "CST complex formation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2029456", "l": "RAC1 and CDC42 activate PAK1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16478", "l": "NAD(+) + prostaglandin E1 => 15-oxoprostaglandin E1 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25536", "l": "ent-copalyl diphosphate = diphosphate + ent-sandaracopimara-8(14),15-diene"}, {"i": "EC:4.2.3.29", "l": "\"Ent-sandaracopimaradiene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37994", "l": "delta-tocopherol + S-adenosyl-L-methionine <=> beta-tocopherol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690988", "l": "3'-incision of DNA by ERCC5 (XPG) in GG-NER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2127562", "l": "STRAP binds phosphorylated TGF-beta receptor complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0070137", "l": "ubiquitin-like protein-specific endopeptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12671", "l": "L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate => H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14382", "l": "4-guanidinobutanal + H2O + NAD(+) => 4-guanidinobutanoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034353", "l": "RNA pyrophosphohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54439", "l": "2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 <=> a (4S)-2,3-dehydroflavan-3,4-diol + CO2 + H(+) + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31459", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate = 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate"}, {"i": "EC:5.3.99.10", "l": "\"Thiazole tautomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28535", "l": "dTTP + H2O => diphosphate + dTMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102328", "l": "3-oxoacid decarboxylase activity"}, {"i": "MetaCyc:RXN-13248"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032034", "l": "myosin II head/neck binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61431", "l": "cis-trans-nepetalactol + NAD(+) <=> cis-trans-nepetalactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29986", "l": "cytidine(in) + H(+)(in) <=> cytidine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66317", "l": "an inositol phosphomannosyl-alpha-1->6-inositol-1-phospho-N-acyl-4R-hydroxysphinganine + H2O => alpha-D-mannosyl-di-(inositol-1-phosphate) + an N-acyl-(4R)-4-hydroxysphinganine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12975", "l": "2 ADP => AMP + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26296", "l": "(1'S,5'S)-averufin + NADPH + O2 <=> 1'-hydroxyversicolorone + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38221", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51869", "l": "dimethylallyl diphosphate + umbelliferone => demethylsuberosin + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664867", "l": "NBR1 binds MAP1LC3B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.417", "l": "\"3-beta-hydroxysteroid-4-beta-carboxylate 3-dehydrogenase (decarboxylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10766", "l": "(4S)-2,3-dehydroleucocyanidin + CO2 + H(+) + H2O + succinate => (2R,3S,4S)-leucocyanidin + 2-oxoglutarate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351901", "l": "Caspase-mediated cleavage of MST3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52817", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => an N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63414", "l": "2,6-dichlorobenzoquinone + chloride + FAD + H(+) + H2O => 2,4,6-trichlorophenol + FADH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42873", "l": "N(4)-aminopropylspermidine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + N(4)-bis(aminopropyl)spermidine + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031683", "l": "G-protein beta/gamma-subunit complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28806", "l": "H2O + L-ascorbate 6-phosphate <=> 3-dehydro-L-gulonate 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31681", "l": "H2O2 + prosolanapyrone III => O2 + prosolanapyrone II"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202168", "l": "Phosphorylation of ZAP-70 by Lck (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0009009", "l": "site-specific recombinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43785", "l": "adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51155", "l": "2 a thiol + L-cysteinyl-[sulfatase] + O2 <=> 3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035255", "l": "ionotropic glutamate receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12408", "l": "L-lysine + NAD(+) = 2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+)"}, {"i": "EC:1.4.1.18", "l": "\"Lysine 6-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66637", "l": "(2E,6E)-farnesyl diphosphate + H2O => (-)-alpha-acorenol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18964", "l": "D-allose + L-lysyl-[protein] <=> H2O + N(6)-(D-psicosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19994", "l": "[thioredoxin]-disulfide + H2O + L-methionine => [thioredoxin]-dithiol + L-methionine (S)-S-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61364", "l": "3beta-sulfooxy-androst-5-en-17-one(in) + ATP + H2O = 3beta-sulfooxy-androst-5-en-17-one(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062154", "l": "N6-mAMP deaminase activity"}, {"i": "RHEA:16001", "l": "H(+) + H2O + N(6)-methyl-AMP = IMP + methylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33634", "l": "ATP + CoA + octanoate <=> AMP + diphosphate + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40155", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.79", "l": "\"Docosahexaenoic acid omega-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42806", "l": "7,8-dihydromethanopterin + AH2 => 5,6,7,8-tetrahydromethanopterin + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25420", "l": "3-hydroxybenzoyl-CoA + AH2 + 2 ATP + 2 H2O = 3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA + A + 2 ADP + 2 H(+) + 2 phosphate"}, {"i": "EC:1.3.99.n1", "l": "\"3-hydroxybenzoyl-CoA reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202541", "l": "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3159253", "l": "MMAB transfers adenosyl group from ATP to cob(I)alamin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33259", "l": "4-aminoimidazole + H(+) + 2 H2O = N-formimidoylglycine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15972", "l": "2 glutathione + H(+) + methylarsonate <=> glutathione disulfide + H2O + methylarsonous acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42228", "l": "17beta-estradiol + A = AH2 + estrone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430311", "l": "Rsu-1 interacts with Pinch1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005340", "l": "nucleotide-sulfate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15339", "l": "CoA + H(+) + phenylglyoxylate => H2O + phenylglyoxylyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18927", "l": "D-glucurono-3,6-lactone + H(+) + NADPH => L-gulono-1,4-lactone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45599", "l": "H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805811", "l": "Release of SEPT4 from mitochondria (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32792", "l": "L-ectoine(in) => L-ectoine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18992", "l": "H(+) + L-valine <=> 2-methylpropan-1-amine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003861", "l": "3-isopropylmalate dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791235", "l": "GADD45A binds AURKA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112435", "l": "Formation of Elongin BC complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27997", "l": "H2O + xanthosine <=> D-ribose + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30328", "l": "beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => all-trans-zeaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35471", "l": "(+)-6a-hydroxymaackiain + S-adenosyl-L-methionine = (+)-pisatin + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.270", "l": "\"(+)-6a-hydroxymaackiain 3-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12980", "l": "H2O + N-phosphocreatine <=> creatine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12328", "l": "[(1->3)-alpha-D-glucosyl](n) + phosphate = [(1->3)-alpha-D-glucosyl](n-1) + beta-D-glucose 1-phosphate"}, {"i": "EC:2.4.1.334", "l": "\"1,3-alpha-oligoglucan phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19030", "l": "3 H(+) + H2O + urea-1-carboxylate => 2 CO2 + 2 NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52041", "l": "L-cystine => 2-aminoprop-2-enoate + S-sulfanyl-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33646", "l": "(9Z)-tetradecenoate + ATP + CoA <=> (9Z)-tetradecenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015265", "l": "urea channel activity"}, {"i": "REACT:R-HSA-507873", "l": "Aquaporins passively transport urea out of cells (Homo sapiens)"}, {"i": "REACT:R-HSA-507875", "l": "Aquaporins passively transport urea into cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852354", "l": "GTSE1 facilitates proteasome-mediated degradation of TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237119", "l": "Acireductone is oxidized to MOB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853444", "l": "AURKA phosphorylates PHLDA1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52998", "l": "[eIF5A protein]-deoxyhypusine + NAD(+) => [eIF5A protein]-N-(4-aminobutylidene)-L-lysine + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49415", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-colitose <=> alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16804", "l": "3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] <=> adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17670", "l": "3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O2 => 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11873", "l": "corticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 18-hydroxycorticosterone + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20782", "l": "ADP + GDP => ATP + GMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709547", "l": "ESTG binds ESR2:chaperone complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27953", "l": "L-phenylalanine(in) <=> L-phenylalanine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38813", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666008", "l": "SCAI binds SRF:MKL1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046175", "l": "Further sulfation on galactose residues produces KSPG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57731", "l": "H(+) + trans-aconitate <=> CO2 + itaconate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051719", "l": "DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52448", "l": "16alpha-hydroxyestrone + UDP-alpha-D-glucuronate = 16alpha-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62966", "l": "alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP + H(+) => beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14184", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 <=> (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3785768", "l": "MRN complex binds DNA double strand breaks (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30201", "l": "2 ATP + benzoyl-CoA + 2 H2O + reduced 2[4Fe-4S]-[ferredoxin] => 2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032267", "l": "tRNA(Ile)-lysidine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928641", "l": "PAK binds RAC and bPIX (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213248", "l": "Transport of antigen loaded MHC II molecules to surface (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612445", "l": "STMN1 gene expression is stimulated by ERBB4s80 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693783", "l": "NAALADases hydrolyse NAAG (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22719", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25531", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34429", "l": "(-)-pinoresinol + H(+) + NADPH => (-)-lariciresinol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428273", "l": "SPHK1 phosphorylates SPG to S1P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4837364", "l": "Secretion of SOD3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51174", "l": "5-methylcytidine(62) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(62) in tRNA(Asp) + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55588", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-sphingoid base = a 1,2-diacyl-sn-glycerol + an inositol-1-phosphoceramide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050271", "l": "S-alkylcysteine lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109857", "l": "MAP2K1 binds MAPK3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139895", "l": "tBID activates BAK protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624668", "l": "CEBPA binds CDKN1A (p21) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54747", "l": "9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37524", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40254", "l": "4-O-methylrhodomycin D + H2O <=> 10-carboxy-13-deoxydaunorubicin + H(+) + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404200", "l": "IGF1,2 binds IGF1R (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15676", "l": "acetoacetyl-CoA + H2O <=> acetoacetate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202709", "l": "JAM2 dimerises (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69140", "l": "RPA binds to the Flap (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2219524", "l": "PDPK1 binds PIP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37598", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "59.112597964682607", "identifiers": [{"i": "GO:0016853", "l": "isomerase activity"}, {"i": "REACT:R-HSA-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Homo sapiens)"}, {"i": "EC:5.-.-.-", "l": "\"Isomerases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-947499", "l": "Exchange of oxygen with sulfur in MoCo (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46641", "l": "7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH => 7alpha-hydroxy-5beta-cholestan-3-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015395", "l": "nucleoside transmembrane transporter activity, down a concentration gradient"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15256", "l": "cis-aconitate + H(+) <=> CO2 + itaconate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60100", "l": "cyanidin + UDP-alpha-D-glucose = cyanidin 3-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59215", "l": "holo-[(hydroxy)phthioceranic acid synthase] + octadecanoyl-AMP <=> AMP + H(+) + octadecanoyl-[(hydroxy)phthioceranic acid synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5263628", "l": "CAV3:TRIM72:DYSF binds ANXAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0043138", "l": "3'-5' DNA helicase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42705", "l": "hercynine + L-cysteine + O2 => H2O + S-(hercyn-2-yl)-L-cysteine S-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28107", "l": "galactitol 1-phosphate + NAD(+) => H(+) + keto-D-tagatose 6-phosphate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19837", "l": "D-sorbitol 6-phosphate + NAD(+) = beta-D-fructose 6-phosphate + H(+) + NADH"}, {"i": "EC:1.1.1.140", "l": "\"Sorbitol-6-phosphate 2-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37200", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63989", "l": "2-thiocytidine + ATP => 2-thiocytidine 5'-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043732", "l": "6-hydroxynicotinate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50782", "l": "(2E)-octenal + H(+) + NADPH => NADP(+) + octanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113705", "l": "RNA Polymerase III Productive Transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868118", "l": "MAPK12 phosphorylates PTPN3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9686920", "l": "PELI1 ubiquitinates RIPK3 at K363 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61876", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-8-hydroperoxy-20-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43826", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935988", "l": "OCLN (Occludin) gene expression is stimulated by RUNX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038100", "l": "nodal binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420977", "l": "Ca permeable AMPA receptor ligand binding (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937792", "l": "RUNX3 binds SRC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216045", "l": "Collagen type I binds integrin alpha11beta1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51821", "l": "ATP(in) + CoA(in) + decanoate(out) + H(+)(out) => AMP(in) + decanoyl-CoA(in) + diphosphate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944242", "l": "Association of procollagen type XXVII (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3296244", "l": "SUCNR1 binds SUCCA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399913", "l": "atRAL binds to RBP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54407", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 2-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39476", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA => (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675656", "l": "EDA:EDAR binds EDARADD (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37569", "l": "1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.48", "l": "\"Staphopain\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55241", "l": "1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O => (9Z)-octadecenoate + 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668395", "l": "CHMP7 binds CC2D1B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2176452", "l": "Degradation of ubiquitinated SMAD2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031736", "l": "CCR11 chemokine receptor binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005010", "l": "insulin-like growth factor-activated receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42161", "l": "(11Z,14Z)-eicosadienoyl-CoA + AH2 + O2 => (5Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58168", "l": "(2E,6E)-farnesyl diphosphate = (-)-5-epi-eremophilene + diphosphate"}, {"i": "EC:4.2.3.199", "l": "\"(-)-5-epieremophilene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018768", "l": "RHOU auto-activates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73577", "l": "CAD hexamer transforms L-Gln to CAP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58012", "l": "cyclic tetraadenylate = 2 5'-hydroxy-diadenylate 2',3'-cylic phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202248", "l": "Phosphorylation of PLC-gamma1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68914", "l": "DNA polymerase alpha:primase binds at the origin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65185", "l": "2-oxoglutarate + O2 + preaustinoid A1 => berkeleyone B + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59120", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + H(+) = 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2"}, {"i": "EC:4.1.1.117", "l": "\"2-((L-alanin-3-ylcarbamoyl)methyl)-2-hydroxybutanedioate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50149", "l": "a fatty acid ethyl ester + H2O => a fatty acid + ethanol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31233", "l": "4-acetamidobutanoate + 2 H(+) + NADH => 4-acetamidobutanal + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49132", "l": "an adenosine in tRNA + S-adenosyl-L-methionine = an N(1)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62009", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20347", "l": "[thioredoxin]-disulfide + H(+) + NADPH => [thioredoxin]-dithiol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416516", "l": "GRK2 sequesters activated Gq (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399988", "l": "AKT1 E17K mutant phosphorylates NR4A1 (NUR77) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000772", "l": "mating pheromone activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399942", "l": "Plexin-A1-4 binds NRP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688786", "l": "ATXN3 binds RAD23 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8867613", "l": "PICALM binds R-SNAREs (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-451033", "l": "(S)-Malate <=> Fumarate + H2O (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51423", "l": "a (2S,3S)-flavan-3-ol + 2 NADP(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65487", "l": "hexan-1-ol + hexanoyl-CoA <=> CoA + hexyl hexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44120", "l": "hexadecanoyl-CoA + octadecan-1-ol = CoA + octadecanyl hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23056", "l": "urea = cyanamide + H2O"}, {"i": "EC:4.2.1.69", "l": "\"Cyanamide hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10391", "l": "GTP + oxaloacetate <=> CO2 + GDP + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53288", "l": "3-dehydro-scyllo-inosose + H2O = 5-dehydro-L-gluconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3640862", "l": "Tankyrase binds AXIN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013004", "l": "RHOA binds effectors at the ER membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662620", "l": "MT3 binds cadmium (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112437", "l": "Formation of NELF complex  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678992", "l": "Ivacaftor:CFTR G551D transports Cl- from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168459", "l": "Lyn activates ERK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28295", "l": "(2E,6E)-farnesyl diphosphate => (E)-beta-caryophyllene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13771", "l": "dihydroxyacetone + H(+) + NADH => glycerol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000721", "l": "(R,R)-butanediol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54827", "l": "H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein] <=> alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36243", "l": "acetate + NADP(+) + trans-anol = NADPH + trans-coumaryl acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31902", "l": "indole + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + indolin-2-one + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18576", "l": "dihydrochelirubine + H(+) + O2 <=> chelirubine + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061995", "l": "ATP-dependent protein-DNA complex displacement activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44190", "l": "1-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66875", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 9-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392749", "l": "Transport of L1 into endosomes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388832", "l": "PI3K binds CD28 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34418", "l": "(1R,4R)-bornane-2,5-dione + FMNH2 + O2 <=> (1R,4R)-5-oxo-1,2-campholide + FMN + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39185", "l": "(3R)-hydroxydocosanoyl-CoA + NADP(+) => 3-oxodocosanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204861", "l": "Interaction of Tie2 and Shc1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19640", "l": "D-nopaline + H2O + NADP(+) <=> 2-oxoglutarate + H(+) + L-arginine + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12741", "l": "ADP + H(+) + H2O = IDP + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52140", "l": "(DNA)-3'-diphospho-5'-guanosine + H2O = (DNA)-3'-phosphate + GMP + 2 H(+)"}, {"i": "EC:3.6.1.72", "l": "\"DNA-3'-diphospho-5'-guanosine diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73797", "l": "FAICAR => IMP + H2O (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37467", "l": "1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48964", "l": "2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59989", "l": "cyclohexane-1-carbonyl-CoA + NADP(+) => cyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21087", "l": "chondroitin 4'-sulfate <=> dermatan 4'-sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785213", "l": "LIPC dimer binds heparin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917700", "l": "MVB Vesicle Formation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33684", "l": "H(+) + L-serine + octadecanoyl-CoA => 3-oxoeicosasphinganine + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015494", "l": "aromatic amino acid:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3311014", "l": "SMAD4 MH2 Domain Mutants do not bind phosphorylated SMAD2 and SMAD3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944246", "l": "Association of procollagen type XXI (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31752", "l": "chlorophyllide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 7(1)-hydroxychlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15049", "l": "GDP-alpha-D-glucose + H2O = D-glucose + GDP + H(+)"}, {"i": "EC:3.2.1.42", "l": "\"GDP-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45030", "l": "2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein] => (2S)-methylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38512", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20379", "l": "5alpha-androstan-3,17-dione + H(+) + NADPH => 3alpha-hydroxy-5alpha-androstan-17-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112510", "l": "IL6ST is tyrosine phosphorylated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16730", "l": "(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) => catechol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623240", "l": "FOXO1 binds PPARGC1A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51937", "l": "2-(glutathione-S-yl)-hydroquinone + glutathione => glutathione disulfide + hydroquinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20163", "l": "myo-inositol + raffinose => alpha-D-galactosyl-(1->3)-1D-myo-inositol + sucrose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59513", "l": "acetylsalicylate + L-seryl-[protein] => O-acetyl-L-seryl-[protein] + salicylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:1904315", "l": "transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71303", "l": "RPE dimers isomerise RU5P to XY5P (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008110", "l": "L-histidine:2-oxoglutarate aminotransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043756", "l": "adenosylcobinamide hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48896", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide a = 3,8-divinyl protochlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}, {"i": "RHEA:48900", "l": "chlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] = 3,8-divinyl chlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.3.7.13", "l": "\"3,8-divinyl protochlorophyllide a 8-vinyl-reductase (ferredoxin)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32612", "l": "(6E)-8-hydroxygeranial + NADP(+) => (6E)-8-oxogeranial + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159761", "l": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-481007", "l": "Exocytosis of platelet alpha granule contents (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20374", "l": "ATP + CoA + propanoate => AMP + diphosphate + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034893", "l": "N-nitrodimethylamine hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140262", "l": "mRNA cap binding complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.59", "l": "\"Protein geranylgeranyltransferase type I\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19860", "l": "a 16alpha-hydroxysteroid + NADP(+) <=> a 16-oxosteroid + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202331", "l": "Recruitment of PLC-gamma1 to SLP-76 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33012", "l": "(+)-artemisinic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] => (+)-artemisinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30989", "l": "(17Z)-protosta-17(20),24-dien-3beta-ol => (S)-2,3-epoxysqualene"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102527", "l": "8-demethylnovobiocate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928656", "l": "gamma-secretase cleaves EPHB2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64093", "l": "3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 => 3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35911", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003746", "l": "translation elongation factor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60913", "l": "cytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-methionine => H(+) + N(3)-methylcytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20987", "l": "a sphingomyelin + H2O <=> an N-acylsphing-4-enine 1-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848110", "l": "SOCS3 binds activated PTK6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70494", "l": "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31395", "l": "15-cis-4,4'-diapophytoene + FAD + H(+) = all-trans-4,4'-diapophytofluene + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008459", "l": "chondroitin 6-sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51455", "l": "O2 + reduced [NADPH--hemoprotein reductase] + ursodeoxycholate <=> beta-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32323", "l": "ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.86", "l": "\"Ent-kaurene monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59742", "l": "CoA + S-octadecanoyl-L-cysteinyl-[protein] => L-cysteinyl-[protein] + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018663", "l": "2,6-dihydroxypyridine 3-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015423", "l": "ABC-type maltose transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368133", "l": "Expression of RORA (ROR-alpha) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53224", "l": "16alpha,17alpha-dihydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] = 3beta,16alpha-dihydroxy-androst-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202960", "l": "Caspase mediated cleavage of C-IAP1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70486", "l": "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098633", "l": "collagen fibril binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50527", "l": "acetyl-CoA + N-terminal L-methionyl-L-isoleucyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41563", "l": "(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FADH2 + O2 <=> (3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FAD + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38441", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10785", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(36)-[histone H3] + O2 => CO2 + formaldehyde + L-lysyl(36)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855375", "l": "PTPN22 dissociates from CSK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17327", "l": "(S)-2-succinylamino-6-oxoheptanedioate + CoA => (S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868230", "l": "SNX9 recruits components of the actin polymerizing machinery (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51181", "l": "cytidine(49) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(49) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2314678", "l": "Aspirin acetylates PTGS1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30318", "l": "1,7-dimethylxanthine + H(+) + NADH + O2 <=> 7-methylxanthine + formaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18814", "l": "(2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate => (3E,5R)-5-carboxy-2-oxohept-3-enedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.16", "l": "\"Levan fructotransferase (DFA-IV-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786034", "l": "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211924", "l": "CYP4B1 12-hydroxylates ARA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047855", "l": "dihydrobunolol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203977", "l": "SAR1 Activation And Membrane Binding (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63279", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 <=> a 1-acyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052905", "l": "tRNA (guanine(9)-N(1))-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2012073", "l": "Autocatalytic phosphorylation of FGFR3c P250R mutant (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63445", "l": "(2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin => GMP + H(+) + oxidized coenzyme F420-0"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954185", "l": "ERBB4s80:TAB2:NCOR1 complex binds GFAP gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250892", "l": "botF LC cleaves target cell VAMP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50770", "l": "anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine => 4-methylamino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050578", "l": "(R)-2-hydroxyacid dehydrogenase activity"}, {"i": "MetaCyc:1.1.1.272-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13666", "l": "GTP => 3',5'-cyclic GMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685838", "l": "CX3 complex binds D-loop structures (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132187", "l": "MBL or ficolin binds an oligosaccharide pattern on the target cell surface (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40832", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420202", "l": "Secretin receptor binds secretin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635609", "l": "Rv3655c binds RNF213 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63103", "l": "H(+) + ilicicolin C + NADPH + O2 <=> ascochlorin + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0140487", "l": "metal ion sequestering activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10719", "l": "D-glucose 6-phosphate <=> 1D-myo-inositol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34754", "l": "ATP + N-acyl-15-methylhexadecasphing-4-enine <=> ADP + H(+) + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61751", "l": "rubusoside + UDP-alpha-D-glucose <=> H(+) + stevioside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395801", "l": "Phosphorylation of LAT by p-SYK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11606", "l": "[(2->8)-O(7),N-diacetyl-alpha-D-neuraminosyl](n) + n CoA => [(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60576", "l": "[methyl-Co(III) tetramethylammonium-specific corrinoid protein] + coenzyme M = [Co(I) tetramethylammonium-specific corrinoid protein] + H(+) + methyl-coenzyme M"}, {"i": "EC:2.1.1.253", "l": "\"[Methyl-Co(III) tetramethylammonium-specific corrinoid protein]:coenzyme M methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014433", "l": "RHOG GEFs activate RHOG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050025", "l": "L-glutamate oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5213464", "l": "RIPK1 is phosphorylated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.99.-", "l": "\"Other intramolecular oxidoreductases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61549", "l": "ent-kaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => ent-7alpha-hydroxykaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30520", "l": "GTP + H(+) + phosphoenolpyruvate => diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2248891", "l": "Active ARSA translocates to the lysosome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19579", "l": "H(+) + luteolin 7-O-beta-D-glucoside + UDP => luteolin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847880", "l": "CYTH proteins bind ARF1:GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956050", "l": "NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018798", "l": "RHOV binds GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64638", "l": "butyl benzoate + CoA => benzoyl-CoA + butan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15987", "l": "CO2 + NADH => formate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936616", "l": "RUNX1 and GATA1 bind the promoter of the GP1BA gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046524", "l": "sucrose-phosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008124", "l": "4-alpha-hydroxytetrahydrobiopterin dehydratase activity"}, {"i": "KEGG.REACTION:R04734"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13946", "l": "(S)-mandelate => (R)-mandelate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20293", "l": "3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH"}, {"i": "EC:1.1.1.96", "l": "\"Diiodophenylpyruvate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086216", "l": "Collagen type VII binds integrin alpha2beta1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31701", "l": "3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al => 4 H(+) + 2 O2 + pentalenene + 4 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39354", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA <=> (2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20371", "l": "glycine betaine + H(+) + H2O2 => betaine aldehyde + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0070138", "l": "ubiquitin-like protein-specific isopeptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43869", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(in) => a 1-acyl-sn-glycero-3-phosphoethanolamine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9038653", "l": "RHCE gene produces Rhesus C or E proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14911", "l": "aldehydo-D-glucuronate + H(+) + NADPH => L-gulonate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54463", "l": "1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5082391", "l": "Trimerization of HSF1 in the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194025", "l": "11-deoxycortisol translocates to the mitochondrion (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603534", "l": "Unknown caspase cleaves NTRK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20584", "l": "H2O + NAD(+) + NH4(+) <=> 2 H(+) + hydroxylamine + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35865", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141159", "l": "TNF-mediated dimerization of procaspase-8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5656070", "l": "FGFBPs bind FGFs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20519", "l": "UDP-N-acetyl-alpha-D-galactosamine => UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446221", "l": "Mannose-1-phosphate converted to GDP-Mannose (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39375", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA = (2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047328", "l": "acyl-phosphate-hexose phosphotransferase activity"}, {"i": "MetaCyc:2.7.1.61-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11528", "l": "2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983426", "l": "Capturing cargo and formation of prebudding complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938231", "l": "RUNX1:CBFB binds CREBBP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-264622", "l": "Cho is acetylated to AcCho by CHAT (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13800", "l": "dolichyl phosphate + H2O <=> di-trans,poly-cis-dolichol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392834", "l": "Activation of EPACs by cAMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004858", "l": "dUTP pyrophosphatase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198270", "l": "PDPK1 phosphorylates AKT at T308 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1297354", "l": "Acrosin Cleavage (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49211", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,24S-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31896", "l": "(2E,6E)-farnesyl diphosphate => (1E,4E,8E)-alpha-humulene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55719", "l": "(S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(2'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388828", "l": "PD-1 binds B7DC and B7H1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198621", "l": "AKT phosphorylates caspase-9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39444", "l": "(2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + NADPH => (11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805109", "l": "CDK2 phosphorylates TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008821", "l": "crossover junction endodeoxyribonuclease activity"}, {"i": "MetaCyc:3.1.22.4-RXN"}, {"i": "EC:3.1.22.4", "l": "\"Crossover junction endodeoxyribonuclease\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62718", "l": "stemphyloxin II => stemphyloxin I"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18611", "l": "H(+) + N(2)-acetyl-L-citrulline + phosphate => carbamoyl phosphate + N(2)-acetyl-L-ornithine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043815", "l": "phosphoribosylglycinamide formyltransferase 2 activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551727", "l": "CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56144", "l": "a quinol + nitrate = a quinone + H2O + nitrite"}, {"i": "EC:1.7.5.1", "l": "\"Nitrate reductase (quinone)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64304", "l": "1-phenylpropylamine + pyruvate = 1-phenylpropan-1-one + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22552", "l": "3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+)"}, {"i": "EC:2.8.2.2", "l": "\"Alcohol sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59266", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51106", "l": "13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158399", "l": "kallikrein binds SERPING1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13945", "l": "(S)-mandelate = (R)-mandelate"}, {"i": "EC:5.1.2.2", "l": "\"Mandelate racemase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41188", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170964", "l": "FRS2 binds to active TrkA receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40962", "l": "2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine <=> 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44191", "l": "(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphate <=> 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090589", "l": "protein-phosphocysteine-trehalose phosphotransferase system transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39969", "l": "2-iminobutanoate => 2-aminobut-2-enoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419011", "l": "Transhomodimerization of Nectins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62287", "l": "2 ATP + L-proline + L-tryptophan + NADPH <=> (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + 2 AMP + 2 diphosphate + H(+) + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47441", "l": "(3S)-hydroxy-(7Z-hexadecenoyl)-CoA + NAD(+) => 3-oxo-(7Z-hexadecenoyl)-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806613", "l": "Keratin tetramers bind to form unit length filaments (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45247", "l": "(3E,5Z)-octadienoyl-CoA <=> (2E,4E)-octadienoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811427", "l": "COPI vesicle uncoating at the ER (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44960", "l": "(2E)-decenoyl-CoA + H(+) + NADPH = decanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29985", "l": "cytidine(out) + H(+)(out) => cytidine(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033192", "l": "calmodulin-dependent protein phosphatase activity"}, {"i": "REACT:R-HSA-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Homo sapiens)"}, {"i": "REACT:R-HSA-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29927", "l": "(R)-pantothenate(in) + Na(+)(in) = (R)-pantothenate(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60395", "l": "Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O <=> Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928615", "l": "EFNBs bind SFKs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050174", "l": "phenylalanine decarboxylase activity"}, {"i": "RHEA:19717", "l": "H(+) + L-phenylalanine = 2-phenylethylamine + CO2"}, {"i": "EC:4.1.1.53", "l": "\"Phenylalanine decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56552", "l": "ATP + L-threonyl-[rhodopsin] = ADP + H(+) + O-phospho-L-threonyl-[rhodopsin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31635", "l": "beta-D-Delta(4)-GlcA-(1->4)-beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc + H2O = 5-dehydro-4-deoxy-D-glucuronate + beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43902", "l": "beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalpatein + H(+) => dalpatein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050102", "l": "cellodextrin phosphorylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45168", "l": "2 (E)-sinapoyl-CoA + spermidine = 2 CoA + 2 H(+) + N(1),N(8)-bis[(E)-sinapoyl]-spermidine"}, {"i": "EC:2.3.1.248", "l": "\"Spermidine disinapoyl transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211191", "l": "Association of DFF with alpha:beta importin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909732", "l": "Phosphorylation of STAT2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8871376", "l": "p-Y281,292-RUFY1 binds PI3P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1878002", "l": "XYLTs transfer Xyl to core protein (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35244", "l": "ADP + H(+) + thiamine diphosphate => adenosine thiamine triphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.-.-", "l": "\"Other enzymes using O(2) as oxidant\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786155", "l": "POLN binds ICL-DNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956639", "l": "RUNX1 binds YAP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786854", "l": "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629245", "l": "NEIL3 D132V does not cleave 5-guanidinohydantoin (Gh) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209815", "l": "Tyrosine is monoiodinated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944261", "l": "Association of procollagen type XIII (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51026", "l": "4-(hydroxymethyl)benzenesulfonate + H2O + NAD(+) => H(+) + NADH + O2 + toluene-4-sulfonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10914", "l": "(R)-pantothenate + AMP + diphosphate + H(+) => (R)-pantoate + ATP + beta-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56491", "l": "O2 + oleanolate + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + hederagenin + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58884", "l": "AH2 + alpha-N-dichloroacetyl-p-aminophenylserinol + 2 O2 = A + chloramphenicol + 2 H2O"}, {"i": "EC:1.14.99.67", "l": "\"Alpha-N-dichloroacetyl-p-aminophenylserinol N-oxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26087", "l": "H2O + limonene 1,2-epoxide + NADP(+) => (4S)-limonene + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19602", "l": "H(+) + NADH + O2 + orcinol => 2,3,5-trihydroxytoluene + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799761", "l": "TP53 binds PPP1R13L (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44223", "l": "15-hydroxypentadecanoate + ATP + CoA <=> 15-hydroxypentadecanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396370", "l": "VTN binds collagens II, III and V (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23003", "l": "(R)-pantoate + NAD(+) <=> (R)-4-dehydropantoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030797", "l": "24-methylenesterol C-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62195", "l": "O2 + peregrinol + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862084", "l": "PILRA,PILRB bind CD99 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52946", "l": "choloyl-24-O-(beta-D-glucuronate) + UDP => cholate + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37890", "l": "S-adenosyl-L-methionine + small RNA 3'-end nucleotide <=> H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099581", "l": "ATPase coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354087", "l": "Recruitment of GRB2 to p-PTK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41133", "l": "1-decanoyl-sn-glycero-3-phosphate + choline + H(+) => 1-decanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009936", "l": "RNASEL cleaves cellular ssRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350058", "l": "Formation of CSL NCOR corepressor complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14339", "l": "adenosine 3',5'-bisphosphate + H(+) + UDP-N-acetyl-alpha-D-galactosamine 4,6-bissulfate => 3'-phosphoadenylyl sulfate + UDP-N-acetyl-alpha-D-galactosamine 4-sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34268", "l": "acetyl-CoA + fumigaclavine B => CoA + fumigaclavine A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58321", "l": "25-substituted-cholesterol + a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine => 25-substituted-cholesteryl beta-D-glucoside + an N-acylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-453342", "l": "PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944257", "l": "Association of procollagen type XXIV (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35969", "l": "12alpha,13alpha-dihydroxyfumitremorgin C + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => fumitremorgin C + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34858", "l": "2 H2O + iminodiacetonitrile <=> N-(cyanomethyl)glycine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602454", "l": "proMMP9 binds TIMP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14773", "l": "2 NADPH + palmatine + S-adenosyl-L-methionine = corydaline + 2 NADP(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.147", "l": "\"Corydaline synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201611", "l": "Caspase-mediated cleavage of Rock-1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9660557", "l": "RAS:GTP binds RAL GDS proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27883", "l": "2',3'-cyclic CMP + H2O => 3'-CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18855", "l": "2-hydroxy-3-oxosuccinate + H(+) + NADH => NAD(+) + tartrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47623", "l": "2-ethylhexyl sulfate + 2-oxoglutarate + O2 <=> 2-ethylhexanal + CO2 + H(+) + succinate + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35010", "l": "D-fucose(in) <=> D-fucose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204863", "l": "Interaction of Tie2 with Ang2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507873", "l": "Aquaporins passively transport urea out of cells (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25696", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008456", "l": "alpha-N-acetylgalactosaminidase activity"}, {"i": "MetaCyc:3.2.1.49-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34351", "l": "(2E)-geranial + H2O + NAD(+) = geranate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.86", "l": "\"Geranial dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948136", "l": "ULK1 Translocates to the mitochondria (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607721", "l": "Activation of NIK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64067", "l": "(1R,2R)-pseudoephedrine + NAD(+) <=> (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163310", "l": "TFAM binds to mitochondrial promoters (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0034596", "l": "phosphatidylinositol phosphate 4-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799332", "l": "ATR phosphorylates TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53806", "l": "allodeoxycholate + ursodeoxycholoyl-CoA => allodeoxycholoyl-CoA + ursodeoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52247", "l": "4 H(+) + 4 Mn(2+) + O2 <=> 2 H2O + 4 Mn(3+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75824", "l": "Ubiquitination of Cyclin D1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102815", "l": "caffeoyl-CoA:delphinidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41342", "l": "10R-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate => (6Z,9Z,12Z)-octadecatrienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22237", "l": "2-deoxy-D-glucose 6-phosphate + H2O => 2-deoxy-D-glucose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5387389", "l": "Hh processing variants are translocated to the cytosol in a VCP-dependent manner (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166387", "l": "The FA anion diffuses away laterally from UCP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55071", "l": "a 12-oxojasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24693", "l": "acetate + eugenol + NADP(+) <=> (E)-coniferyl acetate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50536", "l": "prostaglandin E2 = H2O + prostaglandin A2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22551", "l": "H2O + L-lysine + O2 <=> (S)-2-amino-6-oxohexanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22209", "l": "3-hydroxyphenylacetate + H(+) + NADH + O2 => H2O + homogentisate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636684", "l": "ndkA dephosphorylates RAB5A:GTP,RAB7A:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36405", "l": "a fatty acid + cholesterol + H(+) => a cholesterol ester + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49598", "l": "H(+) + N-acyl-D-galactosylsphing-4-enine + UDP => an N-acylsphing-4-enine + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32580", "l": "(2E)-geranyl diphosphate => (1R,5R)-beta-pinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35812", "l": "(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol => (-)-medicarpin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50535", "l": "acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58153", "l": "H2O + NAD(+) + phosphonoacetaldehyde => 2 H(+) + NADH + phosphonoacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389762", "l": "Phosphorylation of PD-1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170964", "l": "FRS2 binds to active TrkA receptor (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043813", "l": "phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63437", "l": "1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + a di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25214", "l": "H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => 2-N,3-O-bis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112271", "l": "The receptor:G-protein complex dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38327", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390909", "l": "HRH2 binds hist (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75850", "l": "Addition of the third nucleotide on the nascent transcript (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31342", "l": "acetate + ATP + holo-[ACP] <=> acetyl-[ACP] + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624798", "l": "LBR binds KPNB1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29010", "l": "H(+)(in) + Mn(2+)(in) <=> H(+)(out) + Mn(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24340", "l": "(R,R)-butane-2,3-diol + NAD(+) = (R)-acetoin + H(+) + NADH"}, {"i": "EC:1.1.1.4", "l": "\"(R,R)-butanediol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22168", "l": "UDP-alpha-D-glucose = UDP-alpha-D-galactose"}, {"i": "EC:5.1.3.2", "l": "\"UDP-glucose 4-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62033", "l": "a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O => a 2-acyl-sn-glycero-3-phosphoglycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.21"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6805981", "l": "HMGB1 release from cells (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15630", "l": "a steroid + 2 H(+) + O2 + 2 reduced [adrenodoxin] => an 11beta-hydroxysteroid + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62111", "l": "an acyl-CoA + sn-glycero-3-phosphoethanolamine <=> a monoacyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661625", "l": "FVIII is secreted (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236970", "l": "Proteasomal clevage of exogenous antigen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868230", "l": "SNX9 recruits components of the actin polymerizing machinery (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13697", "l": "ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)"}, {"i": "EC:2.7.1.15", "l": "\"Ribokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853496", "l": "SCF:FBXL7 binds AURKA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867344", "l": "OMA1 hydrolyses OPA1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672951", "l": "Inactive RAFs bind YWHAB (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917841", "l": "Acidification of Tf:TfR1 containing endosome (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65890", "l": "4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-glutamate => 2-oxoglutarate + 3-hydroxy-L-kynurenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610723", "l": "GLI proteins bind SUFU (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2129353", "l": "Tropoelastin associates with microfibrils (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213241", "l": "Formation of nonameric complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212432", "l": "Formation of DRIP coactivator complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213244", "l": "Loading of antigenic peptides (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672973", "l": "MAP2Ks phosphorylate MAPKs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14166", "l": "acetyl-CoA + L-aspartate => CoA + H(+) + N-acetyl-L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10490", "l": "5,10-methenyltetrahydrofolate + ADP + phosphate => 5-formyltetrahydrofolate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070457", "l": "D-galactose-1-phosphate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36588", "l": "an aldopyranose + NADP(+) => aldono-1,5-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21620", "l": "FMNH2 + NAD(+) = FMN + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11858", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+) => 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956684", "l": "ITCH polyubiquitinates TP73 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982765", "l": "Growth hormone forms dimers and oligomers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5669240", "l": "FLNA binds PAK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32862", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol <=> a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374681", "l": "L1 and NCAM1 engaged in cis-interaction (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43367", "l": "L-erythro-N-acylsphing-4-enine + UDP-alpha-D-glucose <=> beta-D-glucosyl-L-erythro-N-acylsphing-4-enine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.43"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419011", "l": "Transhomodimerization of Nectins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48428", "l": "1-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928576", "l": "RHOA:GTP binds ROCK, activating it (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28087", "l": "2 H2O2 + Reactive Blue 5 => 2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H(+) + 2 H2O + phthalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806394", "l": "TP53 and AP-1 stimulate MSH2 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56247", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl hexadecanoate + apo--[retinol-binding protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55014", "l": "(3R)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+) => (1S,4R)-1-hydroxylimonen-2-one + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22981", "l": "a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] => dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-981539", "l": "C3b binds to cell surface (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52104", "l": "a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656230", "l": "Defective B4GALT1 does not transfer Gal to the keratan chain (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373074", "l": "Receptor CCR9  binds CCL25 ligand (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24705", "l": "NAD(+) + UDP-alpha-D-glucuronate <=> CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34412", "l": "cannabigerolate + O2 => cannabidiolate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626962", "l": "SIRT1 deacetylates FOXO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16285", "l": "D-octopine + H2O + NAD(+) = H(+) + L-arginine + NADH + pyruvate"}, {"i": "EC:1.5.1.11", "l": "\"D-octopine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373129", "l": "fumarate + FADH2 <=> succinate + FAD (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9690449", "l": "S1PR1 bind S1P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13359", "l": "3-oxopropanoate + H(+) + NADH => 3-hydroxypropanoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19585", "l": "lithocholate + NAD(+) = 3-oxo-5beta-cholan-24-oate + H(+) + NADH"}, {"i": "EC:1.1.1.52", "l": "\"3-alpha-hydroxycholanate dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53229", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44545", "l": "a fatty acid(out) + ATP + H2O => a fatty acid(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35964", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin A => fumitremorgin C + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29564", "l": "ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate"}]}
{"type": "biolink:MolecularActivity", "ic": "81.20444558259193", "identifiers": [{"i": "GO:0008172", "l": "S-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21423", "l": "NADP(+) + prostaglandin I2 <=> 15-dehydro-prostaglandin I2 + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37044", "l": "ATP + H2O + L-alanyl-L-glutamate(out) => ADP + H(+) + L-alanyl-L-glutamate(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33937", "l": "H(+) + 2 H2O + 2 L-citrulline + NAD(+) + 2 nitric oxide => 2 N(omega)-hydroxy-L-arginine + NADH + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76386", "l": "CYP1A2 S-demethylates 6MMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-196929", "l": "FLAD1 phosphorylates FMN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167427", "l": "Opioid dissociates from MOR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25856", "l": "(9Z)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25444", "l": "(2E,6E)-farnesyl diphosphate = (1E,4E)-germacrene B + diphosphate"}, {"i": "EC:4.2.3.71", "l": "\"(E,E)-germacrene B synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391934", "l": "DP2 receptor can bind PGD2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001406", "l": "glycerophosphodiester transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8867613", "l": "PICALM binds R-SNAREs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43195", "l": "cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045462", "l": "trichothecene 3-O-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654569", "l": "Activated FGFR1 binds FRS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399930", "l": "Activation of PAK by Rac1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158399", "l": "kallikrein binds SERPING1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090585", "l": "protein-phosphocysteine-L-ascorbate-phosphotransferase system transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48721", "l": "aurachin B + H2O + NAD(+) => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59458", "l": "H(+) + NADPH + tetradecanal => NADP(+) + tetradecan-1-ol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047289", "l": "galactosyldiacylglycerol alpha-2,3-sialyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2197698", "l": "Src phosphorylate WASP,N-WASP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636669", "l": "esxA binds ENO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12807", "l": "(S)-N-methylcanadine + S-adenosyl-L-homocysteine => (S)-canadine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.134", "l": "\"Galactolipid O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19959", "l": "2 9-riburonosylhypoxanthine + 2 H(+) => 2 5'-dehydroinosine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38718", "l": "ATP + choline(out) + H2O <=> ADP + choline(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44325", "l": "1-butyrylglycerol + H2O => butanoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3560804", "l": "Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38992", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O => 1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213208", "l": "Type X collagen associates with collagen type II fibrils (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14221", "l": "H2O + monomethyl sulfate = H(+) + methanol + sulfate"}, {"i": "EC:3.1.6.16", "l": "\"Monomethyl-sulfatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948757", "l": "AKT phosphorylates MKRN1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44201", "l": "12-methyloctadecanoate + ATP + CoA => 12-methyloctadecanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44904", "l": "alpha-D-glucose 6-phosphate + H2O = alpha-D-glucose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050533", "l": "5-phytase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804229", "l": "JMY, TTC5 and EP300 bind (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68610", "l": "Formation of ORC(2-5) complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56303", "l": "[thioredoxin]-dithiol + S-sulfanyl-L-cysteinyl-[protein] <=> [thioredoxin]-disulfide + H(+) + hydrogen sulfide + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23278", "l": "3-methyl-2-oxobutanoate + formaldehyde => 2-dehydropantoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33811", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 glycine + 3 L-threonine = 6 AMP + corynebactin + 6 diphosphate + 3 H(+) + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097600", "l": "exoxylanase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74726", "l": "Dissociation of insulin from insulin receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389463", "l": "Proteinase-activated receptors can bind thrombin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190520", "l": "Association of Golgi  transport vesicles with microtubules (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43478", "l": "10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate => (6Z,9Z,12Z)-octadecatrienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57300", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O = a 2'-deoxyguanosine in DNA + H(+) + lactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209114", "l": "Translation of p16INK4A mRNA is inhibited by miR-24 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20526", "l": "ATP + ethylamine + L-glutamate => ADP + H(+) + N(5)-ethyl-L-glutamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12505", "l": "NAD(+) + thiomorpholine-3-carboxylate => 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65329", "l": "A + chrodrimanin F => AH2 + chrodrimanin H"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2464822", "l": "RDH12 reduces atRAL to atROL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1638845", "l": "CERK phosphorylates CERA to form C1P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018555", "l": "phenanthrene dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433986", "l": "activated IKKs phosphorylates IkB alpha causing the NFkB complex to dissociate from the  phospho-IkB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047704", "l": "bile-salt sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004642", "l": "phosphoribosylformylglycinamidine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2473186", "l": "FSTL3 binds Activin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140332", "l": "lipopolysaccharide transfer activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-167419", "l": "The receptor:G-protein complex releases GDP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165127", "l": "GEF binds to the inactive DRheb (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11638", "l": "15-oxoprostaglandin E1 + H(+) + NADPH => NADP(+) + prostaglandin E1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4615910", "l": "SUMOylation of PCNA with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59809", "l": "L-tyrosine => D-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428917", "l": "G13 activation by TP receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803890", "l": "SFN dimerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22722", "l": "ADP + H(+) + N(pros)-phospho-L-histidyl-[protein] => ATP + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782264", "l": "CTU1:CTU2:URM1 thiolates uridine-34 in tRNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53214", "l": "17beta,18-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-215526", "l": "CYP4F3 20-hydroxylates LTB4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59151", "l": "ATP + CoA + marinolate C <=> AMP + diphosphate + marinoloyl-CoA C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14204", "l": "D-lyxose <=> D-xylulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48102", "l": "H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine => L-arginyl-[protein] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42322", "l": "a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5221061", "l": "TDG excises 5-carboxylcytosine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877620", "l": "ECE2 cleaves EDN1(53-90) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140214", "l": "TP53 stimulates PMAIP1 (NOXA) expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618004", "l": "FOXO:SMAD complex binds CDKN1A gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41008", "l": "(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin => 6-linalyl-2-O,3-dimethylflaviolin + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004612", "l": "phosphoenolpyruvate carboxykinase (ATP) activity"}, {"i": "RHEA:18617", "l": "ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate"}, {"i": "EC:4.1.1.49", "l": "\"Phosphoenolpyruvate carboxykinase (ATP)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972948", "l": "POU5F1 (OCT4), SOX2, NANOG bind the GSC promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30266", "l": "H2O2 + 2 L-ascorbate <=> 2 H2O + 2 monodehydro-L-ascorbate radical"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49637", "l": "H2O + methylglyoxal + O2 => H(+) + H2O2 + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013021", "l": "GDIs block activation of RHOB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36883", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805059", "l": "CK2:FACT phosphorylates TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45713", "l": "3-dehydrocarnityl-CoA + CoA => acetyl-CoA + N,N,N-trimethylglycyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357472", "l": "PAK1-3 autophosphorylates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29647", "l": "alpha-maltopentaose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltotetraose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-933533", "l": "Dimerization of p-IRF7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60350", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34117", "l": "H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine => carboxynorspermidine + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51100", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16124", "l": "5,6-dihydrouracil + H2O <=> 3-(carbamoylamino)propanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114306", "l": "SMAC binds XIAP:Caspase-3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2467794", "l": "Resolution of sister chromatids (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56842", "l": "(2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate + H(+) => 5-amino-2-hydroxybenzoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22822", "l": "3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP => 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17404", "l": "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate <=> 4-carboxy-2-hydroxy-cis,cis-muconate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27634", "l": "5-dehydro-D-gluconate + NADP(+) = 2,5-didehydro-D-gluconate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58668", "l": "3-deoxyfructose + NADP(+) = 3-deoxyglucosone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39508", "l": "3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11709", "l": "H2O + IMP + NAD(+) => H(+) + NADH + XMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27284", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+) => 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604763", "l": "Autocatalytic activation of MMP7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209823", "l": "Tyrosine is hydroxylated to dopa (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66901", "l": "acetyl-CoA + L-tryptophan + malonyl-CoA => CO2 + 2 CoA + cyclo-acetoacetyl-L-tryptophan + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45140", "l": "2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O = CO2 + L-glutamyl-[protein] + O2 + phylloquinol"}, {"i": "EC:4.1.1.90", "l": "\"Peptidyl-glutamate 4-carboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36327", "l": "ADP + dimethylallyl diphosphate = diphosphate + N(6)-(dimethylallyl)adenosine 5'-diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9640195", "l": "RRAGA,B hydrolyzes GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390929", "l": "HTR1 and 5A receptors can bind serotonin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805022", "l": "USP2 binds the heterodimer of MDM2 and MDM4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-593685", "l": "Netrin-4 binds DCC/UNC5A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668605", "l": "RAC2:GTP binds NOX2 complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112430", "l": "Formation of P-TEFb complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176973", "l": "Association of MCM8 with ORC:origin complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008791", "l": "arginine N-succinyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8939201", "l": "ESR dimerizes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29990", "l": "adenosine(in) + H(+)(in) <=> adenosine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865182", "l": "OTUD7A hydrolyses K11diUb (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050626", "l": "trimethylamine-N-oxide reductase (cytochrome c) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1433415", "l": "Activation of RAC1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202174", "l": "Activation of ZAP-70 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65223", "l": "(1S,2S)-1,2-dihydrobenzene-1,2-diol + NADP(+) <=> catechol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10971", "l": "a carboxylate + CoA + GTP <=> an acyl-CoA + GDP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51080", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062181", "l": "1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity"}, {"i": "RHEA:49192", "l": "calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102834", "l": "1-18:1-2-16:0-monogalactosyldiacylglycerol acyl-lipid omega-6 desaturase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047344", "l": "glucose-1-phosphate guanylyltransferase activity"}, {"i": "RHEA:10708", "l": "alpha-D-glucose 1-phosphate + GTP + H(+) = diphosphate + GDP-D-glucose"}, {"i": "EC:2.7.7.34", "l": "\"Glucose-1-phosphate guanylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782820", "l": "USP17 deubiquitinates SUDS3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111237", "l": "Formation of ADAR1 homodimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64546", "l": "8 A + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] + 2 S-adenosyl-L-homocysteine => acetyl-CoA + 8 AH2 + ATP + 4 H(+) + holo-[ACP] + L-tyrosine + 7 malonyl-CoA + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18456", "l": "[(1->2)-beta-D-glucosyl](n)(in) + ATP + H2O <=> [(1->2)-beta-D-glucosyl](n)(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11629", "l": "a 2-oxocarboxylate + H(+) => an aldehyde + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64158", "l": "a fatty acid + L-methionine => an N-(fatty acyl)-L-methionine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-481009", "l": "Exocytosis of platelet dense granule content (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66035", "l": "alpha-D-mannose 1-phosphate + GDP-alpha-D-glucose <=> alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352059", "l": "SLC6A15-mediated amino acid uptake (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189488", "l": "UROS transforms HMB to URO3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619355", "l": "CaMKK autophosphorylates in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981892", "l": "Active G alpha (z) binds RGS proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032564", "l": "dATP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807826", "l": "LDHAL6B reduces PYR to LACT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045129", "l": "NAD-independent histone deacetylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874082", "l": "MET phosphorylates PTK2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12191", "l": "2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase]-(R)-N(6)-lipoyl-L-lysine + H(+) <=> [dihydrolipoyllysine-residue succinyltransferase]-(R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64172", "l": "L-altrarate = galactarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26201", "l": "ammeline + H(+) + H2O = ammelide + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38486", "l": "a 2,3-diacyl-sn-glycerol + H2O <=> a 2-acylglycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805276", "l": "CDK5 phosphorylates TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48671", "l": "20-hydroxy-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33526", "l": "ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + H2O <=> acetate + ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31345", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047602", "l": "acetoacetate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66814", "l": "8 CO2 + 9 CoA + 7 H2O + 13 NADP(+) + wortmanamide B => 5-aminopentanoate + acetyl-CoA + 20 H(+) + 8 malonyl-CoA + 13 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1251922", "l": "PLCG1 phosphorylation by p-EGFR:p-ERBB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.32", "l": "\"Brachyurin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180710", "l": "Rev:importin beta:B23 recruited to the nuclear pore (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19500", "l": "H(+) + L-aspartate <=> beta-alanine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31123", "l": "muconolactone = (4,5-dihydro-5-oxofuran-2-yl)-acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49399", "l": "20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5666001", "l": "Profilin:G-actin binds MKL1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390663", "l": "ADRA2A,B,C bind ADR,NAd (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26402", "l": "all-trans-10'-apo-beta-carotenal + O2 => (2E,4E,6E)-4-methylocta-2,4,6-trienedial + 13-apo-beta-carotenone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050199", "l": "piperidine N-piperoyltransferase activity"}, {"i": "KEGG.REACTION:R03994"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23999", "l": "a ribonucleoside 5'-triphosphate + H2O <=> a ribonucleoside 5'-phosphate + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46469", "l": "an N-(acyl)-sphingosylphosphocholine(in) + ATP + H2O => ADP + an N-(acyl)-sphingosylphosphocholine(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070411", "l": "I-SMAD binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047386", "l": "fructose-2,6-bisphosphate 6-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375138", "l": "CDO binds BOC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190261", "l": "FGFR3c binds to FGF (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43985", "l": "(2E,6E)-farnesol + H(+) + NADPH + O2 => (2E,6E)-omega-hydroxy-farnesol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018787", "l": "4-chlorobenzoyl-CoA dehalogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.25", "l": "\"Vibriolysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12455", "l": "1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030165", "l": "PDZ domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47495", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH <=> isodeoxycholate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009485", "l": "IL34:CSF1 binds CSF1R (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12725", "l": "D-iditol + NAD(+) = H(+) + keto-D-sorbose + NADH"}, {"i": "EC:1.1.1.15", "l": "\"D-iditol 2-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805399", "l": "TAF1 phosphorylates TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42995", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (R)-nephthenol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3159253", "l": "MMAB transfers adenosyl group from ATP to cob(I)alamin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53841", "l": "3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADP(+) => 7,12-dioxo-lithocholate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.2.3", "l": "\"Trimethylamine-N-oxide reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45519", "l": "[phycoerythrocyanin beta-subunit]-Cys(155)-phycocyanobilin <=> (2R,3E)-phycocyanobilin + apo-[phycoerythrocyanin beta-subunit]-Cys(155)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944216", "l": "Association of procollagen type XV (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0019825", "l": "oxygen binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18438", "l": "4-CDP-2-C-methyl-D-erythritol + ATP => 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43608", "l": "agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O = 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate"}, {"i": "EC:6.3.4.22", "l": "\"tRNA(Ile)(2)-agmatinylcytidine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28742", "l": "Cd(2+)(in) + H(+)(out) <=> Cd(2+)(out) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.405", "l": "\"Ribitol-5-phosphate 2-dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54337", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline => 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28503", "l": "NAD(+) + S-(hydroxymethyl)mycothiol => H(+) + NADH + S-formylmycothiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-163310", "l": "TFAM binds to mitochondrial promoters (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35012", "l": "D-fucose(in) + H(+)(in) => D-fucose(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28165", "l": "cytidine + GTP <=> CMP + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37629", "l": "1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49510", "l": "2-(phosphinatomethylidene)butanedioate + H2O => phosphinomethylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51338", "l": "8-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53316", "l": "GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)"}, {"i": "EC:2.4.1.348", "l": "\"N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391905", "l": "Oxoeicosanoid receptor can bind oxoeicosanoid (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41771", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E)) <=> CMP + ganglioside GT1a (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0034068", "l": "aminoglycoside nucleotidyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653974", "l": "Ragulator binds Rag dimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35482", "l": "(1'S,5'R)-5'-hydroxyaverantin + NAD(+) <=> (S)-5'-oxoaverantin + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33866", "l": "menaquinone-7 + succinate <=> fumarate + menaquinol-7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48137", "l": "ganglioside GM3 + H2O => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186780", "l": "PI3-kinase binds to the active receptor (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43764", "l": "ATP + chenodeoxycholate + CoA = AMP + chenodeoxycholoyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2172433", "l": "Collagen type XIX degradation (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39558", "l": "3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863471", "l": "LDLR is bound by DAB2 and ARH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374665", "l": "DCC interaction with SIAH1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13987", "l": "ADP + H(+) + O-phospho-L-homoserine => ATP + L-homoserine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047379", "l": "ADP-dependent short-chain-acyl-CoA hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44760", "l": "2-methoxy-6-all-trans-nonaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40907", "l": "2 2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033042", "l": "umami taste receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21661", "l": "benzaldehyde + H2O + NADP(+) => benzoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31645", "l": "H(+) + mycinamicin III + S-adenosyl-L-homocysteine => mycinamicin VI + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112437", "l": "Formation of NELF complex  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3159259", "l": "MMAA:MUT binds AdoCbl (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18242", "l": "D-lysine => (2R,5S)-2,5-diaminohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1362416", "l": "Frataxin binds iron (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681375", "l": "KIT binds ripretinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661217", "l": "MT1A binds zinc (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015252", "l": "proton channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030553", "l": "cGMP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56439", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9656891", "l": "OPN1SW binds 11cRAL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48989", "l": "NADH + O2 + rifampicin => 2'-N-hydroxyrifampicin + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41233", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35187", "l": "(Z)-3-aminoperacrylic acid + AH2 = (Z)-3-aminoacrylate + A + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48450", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetyl-beta-D-galactosamine => H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60165", "l": "a guanosine in RNA + S-adenosyl-L-methionine => an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450533", "l": "PKCdelta phosphorylates HuR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14651", "l": "demethylmacrocin + dTDP + H(+) => demethyllactenocin + dTDP-beta-L-mycarose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49925", "l": "(R)-carnitine(out) + O-acyl-(R)-carnitine(in) => (R)-carnitine(in) + O-acyl-(R)-carnitine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805059", "l": "CK2:FACT phosphorylates TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10977", "l": "H(+) + NADH + O2 + quinolin-2-ol => 5,6-dihydroquinoline-2,5,6-triol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36196", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a carboxylate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22738", "l": "5,10-methenyltetrahydrofolate + NH4(+) => 5-formimidoyltetrahydrofolate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43280", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58722", "l": "H2O + NADP(+) + trans-(S)-nicotine N(1')-oxide => (S)-nicotine + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44159", "l": "1D-myo-inositol 5-phosphate + H2O <=> myo-inositol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19728", "l": "H(+) + UDP-alpha-D-galacturonate <=> CO2 + UDP-beta-L-arabinopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35878", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783880", "l": "PIPOX oxidises PPCA to P6C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10193", "l": "ATP + H2O + sulfate(out) => ADP + H(+) + phosphate + sulfate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-213406", "l": "Disassociation of PLC-gamma1 from LAT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53739", "l": "a 2-halobenzoate + H(+) + NADH + O2 <=> a halide anion + catechol + CO2 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15060", "l": "(9Z)-octadecenoyl-[ACP] + H2O <=> (9Z)-octadecenoate + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18498", "l": "L-ribulose 5-phosphate => L-xylulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944454", "l": "mTORC1 phosphorylates MAF1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2213208", "l": "Type X collagen associates with collagen type II fibrils (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25472", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + gamma-himachalene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1861788", "l": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39562", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA <=> (2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005289", "l": "high-affinity arginine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033408", "l": "UCG codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11354", "l": "acetyl phosphate + ADP => acetate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52450", "l": "16alpha-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha-hydroxyestrone + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5669013", "l": "EDA-3 binds EDA2R (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015068", "l": "glycine amidinotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26440", "l": "3-oxopropanoate + H(+) + NADPH => 3-hydroxypropanoate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5580269", "l": "Defective CYP11A1 does not cleave 20a,22b-DHCHOL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23185", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate => (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41371", "l": "1-O-tetradecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61221", "l": "1,2-dihexadecanoyl-sn-glycero-3-CDP + 1D-myo-inositol 3-phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66766", "l": "ADP + folate(out) + H(+) + phosphate => ATP + folate(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21112", "l": "globoside Gb3Cer (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose"}, {"i": "EC:3.2.1.47", "l": "\"Galactosylgalactosylglucosylceramidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65314", "l": "a 3-oxo-ultra-long-chain mono-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP] => an ultra-long-chain mono-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28052", "l": "NAD(+) + phosphate => H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166038", "l": "GPI-bound CD14 binds LPS (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54215", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2 <=> 2-(prostaglandin G2)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14829", "l": "hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine"}, {"i": "EC:2.5.1.47", "l": "\"Cysteine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60974", "l": "H(+) + hexanal + NADH => hexan-1-ol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50819", "l": "androst-4-ene-3,17-dione + H(+) + NADPH <=> 5alpha-androstan-3,17-dione + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18036", "l": "benzoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxybenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928597", "l": "EPH:EFN dimers tetramerise (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9606151", "l": "Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35441", "l": "archaetidylserine + CMP + H(+) => CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8873923", "l": "STARD10 binds LPCAT1 and PC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21001", "l": "1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene => 1,2,3,5-tetrahydroxybenzene + 1,3,5-trihydroxybenzene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033900", "l": "ribonuclease F activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36466", "l": "glycyl-L-glutamate + H2O <=> glycine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51500", "l": "ATP + N-acetyl-D-muramate = ADP + H(+) + N-acetyl-D-muramate 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38236", "l": "(9Z)-octadecenoyl-CoA + octadecan-1-ol => 1-O-octadecyl (9Z)-octadecenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54024", "l": "2-oxoglutarate + L-histidyl-[ribosomal protein uL15] + O2 = (3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24832", "l": "ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide <=> ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40364", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19797", "l": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18419", "l": "CMP + ganglioside GM3 (d18:1(4E)) + H(+) => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44584", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-(1'-sn-glycerol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42447", "l": "L-aspartate + NADP(+) <=> H(+) + iminosuccinate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.128"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58831", "l": "(9S,10R)-epoxy-octadecanoate + H2O <=> 9R,10R-dihydroxyoctadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26403", "l": "(2E,4E,6E)-4-methylocta-2,4,6-trienedial + 13-apo-beta-carotenone => all-trans-10'-apo-beta-carotenal + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371591", "l": "Trimerization of cytosolic HSF1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41554", "l": "diphosphate + ophiobolin F => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56161", "l": "an archaeal dolichyl alpha-D-glucosyl phosphate + UDP-alpha-D-glucuronate => an archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008267", "l": "ESR1 binds to TGFA gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47200", "l": "(24S)-7alpha-dihydroxycholesterol + NAD(+) = (24S)-7alpha,24-dihydroxycholest-4-en-3-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45822", "l": "2-methylfumaryl-CoA + succinate => mesaconate + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727349", "l": "XDH dehydrogenates xanthine to form urate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19655", "l": "CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH => CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36280", "l": "H(+) + NADH + O2 + theophylline => 3-methylxanthine + formaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161794", "l": "Arachidonic acid is converted to HXA3/B3 by ALOX12 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60130", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate => 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.10.1.-", "l": "\"Acting on sulfur-nitrogen bonds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.39", "l": "\"Glucan endo-1,3-beta-D-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17438", "l": "2,4-dichloro-5-oxo-2,5-dihydro-2-furylacetate => (2E,4E)-2,4-dichloromuconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196026", "l": "Dab2 is recruited to the junctional plaques (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65229", "l": "(1S,2S)-1,2-dihydronaphthalene-1,2-diol + NADP(+) => H(+) + NADPH + naphthalene-1,2-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62371", "l": "Fe(2+)(out) + 2 hydrogencarbonate(out) <=> Fe(2+)(in) + 2 hydrogencarbonate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47765", "l": "S-adenosyl-L-methionine + uridine(1369) in 16S rRNA => 2'-O-methyluridine(1369) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22617", "l": "2 H(+) + O2 + 2 sulochrin => 2 (2R)-bisdechlorogeodin + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5082391", "l": "Trimerization of HSF1 in the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53180", "l": "D-erythrose = D-erythrulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.20"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050649", "l": "testosterone 6-beta-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374680", "l": "L1 trans-homophilic interaction (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003985", "l": "acetyl-CoA C-acetyltransferase activity"}, {"i": "REACT:R-HSA-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30008", "l": "ATP + H2O + L-arabinose(out) => ADP + H(+) + L-arabinose(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981606", "l": "Myoglobin binds oxygen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0042086", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839107", "l": "BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3. (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17164", "l": "2,6-dioxo-6-phenylhexa-3-enoate + H2O <=> 2-oxopent-4-enoate + benzoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5362522", "l": "ALDHs oxidise atRAL to atRA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357845", "l": "RIPK1 is deubiquitinated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19974", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => H(+) + S-methyl-5'-thioadenosine + spermine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26006", "l": "di-trans,nona-cis-dodecaprenyl phosphate + UDP-alpha-D-galacturonate = beta-D-galacturonosyl di-trans,nona-cis-dodecaprenyl phosphate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198669", "l": "p38MAPK phosphorylates MSK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0016727", "l": "oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor"}, {"i": "EC:1.17.3.-", "l": "\"With oxygen as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57994", "l": "(20S)-ginsenoside F2 + H(+) + UDP => (20S)-ginsenoside C-K + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611851", "l": "ADRB2 bind ADR,NAd (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44802", "l": "2-demethylmenaquinol-6 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-hexaprenyl diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665406", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1008270", "l": "Activated TAK1 leaves endosome membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23824", "l": "(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) = 2,3-dihydroxybenzoate + H(+) + NADH"}, {"i": "EC:1.3.1.28", "l": "\"2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033792", "l": "bile-acid 7alpha-dehydroxylase activity"}, {"i": "MetaCyc:RXN-8659"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52688", "l": "3-phenyllactate + NAD(+) = 3-phenylpyruvate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13094", "l": "an N-acylsphing-4-enine + UDP-alpha-D-galactose => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052771", "l": "coenzyme F390-G hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25806", "l": "3-aminopropanal + H2O2 + spermidine => H2O + O2 + spermine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801687", "l": "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015533", "l": "shikimate:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9687625", "l": "ATP binds MLKL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3828025", "l": "DCN (decorin) degradation by MMP14 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173754", "l": "Properdin stabilizes C3b:Bb bound to cell surfaces (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58634", "l": "glyoxylate + tetradecamide => N-tetradecanoyl-(2S)-hydroxyglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3321883", "l": "MSL acetylates histone H4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428750", "l": "Gq activation by TP receptor (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042010", "l": "interleukin-15 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31115", "l": "ATP + biotin + H(+) = biotinyl-5'-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423728", "l": "AFXBO translocates from cytosol to nucleoplasm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15351", "l": "L-ornithine + N-acetyl-L-glutamate => L-glutamate + N(2)-acetyl-L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592241", "l": "Expression of SSBP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16795", "l": "CO2 + D-pantetheine 4'-phosphate => H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682311", "l": "Defective ABCA12 does not transport lipids from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14897", "l": "apigenin + 3 H(+) + 2 NADPH + O2 = 2-hydroxy-2,3-dihydrogenistein + H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13159", "l": "2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH => (R)-glycerate + CO2 + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016430", "l": "tRNA (adenine-N6-)-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391913", "l": "FPR2 binds FPR2 ligands (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2029456", "l": "RAC1 and CDC42 activate PAK1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451900", "l": "IL2RB binds JAK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40015", "l": "(+)-copalyl diphosphate + H2O = 13-epi-manool + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-383190", "l": "HCO3- transport through ion channel (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209924", "l": "Dopa is decarboxylated to dopamine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49307", "l": "a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O <=> a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30828", "l": "UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose => UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624131", "l": "UNC119B binds myristoylated proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19282", "l": "(7S)-marmesin + O2 + reduced [NADPH--hemoprotein reductase] => acetone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + psoralen"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13334", "l": "beta-D-fructose 2,6-bisphosphate + H2O => beta-D-fructose 2-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9681375", "l": "KIT binds ripretinib (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5228992", "l": "ROCK1,ROCK2 are activated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903264", "l": "nitrate reductase activity involved in anaerobic electron transport chain"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204949", "l": "NRIF and TRAF6 may activate JNK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.126"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69005", "l": "Cdc6 protein is phosphorylated by CDK (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050458", "l": "decylhomocitrate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58681", "l": "A + FADH2 => AH2 + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018505", "l": "cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51517", "l": "(R)-reticuline + S-adenosyl-L-methionine => (R)-tembetarine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37325", "l": "glycine + L-methionine => glycyl-L-methionine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534388", "l": "Progesterone Activation Of CatSper (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41256", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30488", "l": "H(+) + N,N-dihydroxy-L-isoleucine => (1E,2S)-2-methylbutanal oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.16"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621370", "l": "SYK autophosphorylates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53443", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050396", "l": "vomifoliol 4'-dehydrogenase activity"}, {"i": "KEGG.REACTION:R04412"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964280", "l": "Active Gq binds BTK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32144", "l": "L-arginine(in) => L-arginine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429955", "l": "CCR4-NOT complex deadenylates mRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9696267", "l": "RND3 binds GTP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61661", "l": "(2E)-geraniol + ATP => (2E)-geranyl phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24150", "l": "(2R)-3-phosphoglycerate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => D-glyceraldehyde 3-phosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9628737", "l": "NEIL1 G83D does not cleave DHU (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879245", "l": "mycothiol binds formaldehyde and is dehydrogenated (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9626928", "l": "CREBBP binds FOXO1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014294", "l": "RAC2 binds effectors at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16875", "l": "(6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53268", "l": "L-ribulose = L-xylulose"}, {"i": "EC:5.1.3.31", "l": "\"D-tagatose 3-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.25", "l": "\"Glycyl endopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52545", "l": "D-erythronate + NAD(+) => 2-dehydro-D-erythronate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33485", "l": "CoA + ergosteryl ester => an acyl-CoA + ergosterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0000703", "l": "oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"}, {"i": "REACT:R-HSA-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419426", "l": "Cannabinoid receptors can bind cannabinoids (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379464", "l": "COMT transfers Met to DOPAC to form HVA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.49", "l": "\"RNA-directed DNA polymerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17672", "l": "3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O2 <=> 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45205", "l": "[Co(I) methanol-specific corrinoid protein] + H(+) + methanol => [methyl-Co(III) methanol-specific corrinoid protein] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47413", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48262", "l": "CMP + ganglioside GD1a + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62863", "l": "acetyl-CoA + 7 H(+) + 7 malonyl-CoA <=> 7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + 7 CO2 + 8 CoA + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-199839", "l": "AKT can phosphorylate RSK (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693609", "l": "ATM phosphorylates TP53 at S15 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114683", "l": "Phosphorylation of Platelet Sec-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57977", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose => (20S)-ginsenoside C-K + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44050", "l": "8,9-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58291", "l": "25-substituted-cholesterol + beta-D-glucosyl-N-octanoylsphing-4E-enine <=> 25-substituted-cholesteryl beta-D-glucoside + N-octanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10095", "l": "a 2'-deoxyribonucleoside 3'-phosphate + H2O <=> a 2'-deoxyribonucleoside + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31054", "l": "(3R)-beta-leucine + H2O + NAD(+) <=> 4-methyl-3-oxopentanoate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42956", "l": "cytidine(38) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.204", "l": "\"tRNA (cytosine(38)-C(5))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9691174", "l": "RAC1 binds effectors at the ER membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193068", "l": "CYP17A1 17-hydroxylates PREG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2129375", "l": "Elastin cross-linking by lysyl oxidase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55651", "l": "2-oxoglutarate + O2 + validoxylamine A <=> CO2 + H(+) + succinate + validoxylamine B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61533", "l": "ent-kaur-16-ene + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30527", "l": "H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate = ADP + ATP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689544", "l": "UCHL5 binds INO80 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40966", "l": "4 2-aminophenol + 3 O2 <=> 2 2-aminophenoxazin-3-one + 6 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72130", "l": "Formation of an intermediate Spliceosomal C (Bact) complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708557", "l": "FBXL17 binds BACH1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956025", "l": "AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59370", "l": "1-octadecanoyl-sn-glycero-3-phosphoserine + 10-hydroxyoctadecanoate + H(+) => 1-octadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23979", "l": "(RNA)-3'-(3'-phosphooxy-ribonucleotide) + ATP <=> (RNA)-3'-(2',3'-cyclophosphooxy)-ribonucleotide + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592436", "l": "Initial activation of proMMP9 by MMPs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5695980", "l": "ACAD10 dehydrogenates S-2MPDA-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41736", "l": "3'-phosphoadenylyl sulfate + a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) = adenosine 3',5'-bisphosphate + beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66990", "l": "4-methylpentanoyl-CoA + AMP + diphosphate => 4-methylpentanoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37623", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32622", "l": "L-threo-7,8-dihydrobiopterin + NADP(+) <=> H(+) + NADPH + sepiapterin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22711", "l": "H2O + S-acylglutathione <=> a carboxylate + glutathione + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645220", "l": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18572", "l": "an aromatic aldehyde + H2O + O2 <=> an aromatic carboxylate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21291", "l": "D-glucose + sn-glycerol 3-phosphate <=> D-glucose 6-phosphate + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9670673", "l": "FIX is secreted (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.1.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448958", "l": "Nuclear translocation of p38 MAPK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16893", "l": "pyridine + S-adenosyl-L-methionine = N-methylpyridinium + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.87", "l": "\"Pyridine N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43856", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) = a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28147", "l": "geranylhydroquinone + O2 + reduced [NADPH--hemoprotein reductase] => 3''-hydroxygeranylhydroquinone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18379", "l": "ADP + H(+) + streptomycin 3''-phosphate => ATP + streptomycin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-622310", "l": "Activated NOD1 oligomerizes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57972", "l": "8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.169", "l": "\"Eupatolide synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022850", "l": "serotonin-gated cation-selective channel activity"}, {"i": "REACT:R-HSA-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Homo sapiens)"}, {"i": "REACT:R-HSA-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168301", "l": "Elongation, Polyadenylation and Termination (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19753", "l": "ATP + diphthine-[translation elongation factor 2] + NH4(+) = AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+)"}, {"i": "EC:6.3.1.14", "l": "\"Diphthine--ammonia ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49447", "l": "(2-aminobenzoyl)acetyl-CoA + H2O <=> (2-aminobenzoyl)acetate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9692880", "l": "HRH3 binds Hist (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668605", "l": "RAC2:GTP binds NOX2 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788622", "l": "p-Y-STATs dimerize (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.99.1.-", "l": "\"Other isomerases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798748", "l": "Exocytosis of secretory granule lumen proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66790", "l": "(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2 => N-methyl-L-dopa + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60147", "l": "ATP + L-glutamate + L-glutamyl-[protein] <=> ADP + H(+) + L-gamma-glutamyl-L-glutamyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427514", "l": "eNoSC deacetylates histone H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265010", "l": "Cystine-bonded Proinsulin translocates from the endoplasmic reticulum to the Golgi (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31387", "l": "(S)-2,3-epoxysqualene = alpha-amyrin"}, {"i": "EC:5.4.99.40", "l": "\"Alpha-amyrin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209792", "l": "N-acetylation of serotonin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60235", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196773", "l": "COASY phosphorylates DP-CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008196", "l": "vitellogenin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21467", "l": "2 H(+) + H2O + thiocyanate <=> carbonyl sulfide + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26127", "l": "FAD + L-proline <=> (S)-1-pyrroline-5-carboxylate + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25534", "l": "diphosphate + ent-cassa-12,15-diene => ent-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211948", "l": "CYP3A4 can N-demethylate loperamide (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51034", "l": "dichlorochromopyrrolate + H(+) + NH4(+) => 7-chloroindole-3-pyruvate imine dimer"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102935", "l": "gypsogenin-UDP-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-9012"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36719", "l": "hexacosenoyl-CoA + sphinganine = CoA + H(+) + N-hexacosenoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430308", "l": "PARVB interacts with Alpha-actinin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1222376", "l": "NOX2 generates superoxide from oxygen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44084", "l": "ATP + CoA + heptadecanoate = AMP + diphosphate + heptadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061758", "l": "2-hydroxyglutarate dehydrogenase activity, forward reaction"}, {"i": "RHEA:21253", "l": "(S)-2-hydroxyglutarate + A => 2-oxoglutarate + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63715", "l": "2 [Fe(II)-cytochrome b5] + a (7Z,10Z,13Z,16Z)-docosatetraenoyl derivative + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl derivative + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27484", "l": "(S)-columbianetin + O2 + reduced [NADPH--hemoprotein reductase] <=> acetone + angelicin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1449687", "l": "Corticosteroids bind to CBG in blood (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791163", "l": "Expression of HSP90B1 (Endoplasmin) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0099122", "l": "RNA polymerase II C-terminal domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862300", "l": "LYZ binds bacterial peptidoglycan (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45124", "l": "acarbose + ATP = acarbose 7(IV)-phosphate + ADP + H(+)"}, {"i": "EC:2.7.1.187", "l": "\"Acarbose 7(IV)-phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638046", "l": "ACY3:Zn2+ dimer hydrolyses mercapturic acids (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791180", "l": "Expression of IGFBP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53088", "l": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 2-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1638845", "l": "CERK phosphorylates CERA to form C1P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050270", "l": "S-adenosylhomocysteine deaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62920", "l": "1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol = 1alpha,2beta,25-trihydroxycholecalciferol + 3-hydroxypropanal"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031759", "l": "Edg-6 sphingosine 1-phosphate receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8847880", "l": "CYTH proteins bind ARF1:GTP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49066", "l": "calcitetrol + H2O + 2 oxidized [adrenodoxin] => 2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70692", "l": "ornithine => putrescine + CO2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-606349", "l": "Mis18 complex binds the centromere (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022911", "l": "CSPG is secreted (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49523", "l": "2-oxoglutarate + N(6)-methyladenosine in mRNA + O2 <=> adenosine in mRNA + CO2 + formaldehyde + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-74723", "l": "Endosome acidification (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60556", "l": "uridine(35) in tRNA(Tyr) = pseudouridine(35) in tRNA(Tyr)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654409", "l": "Activated FGFR3 binds FRS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38846", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53591", "l": "NAD(+) + resolvin D2 <=> 16-oxoresolvin D2 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50247", "l": "17alpha-hydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxyandrost-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645428", "l": "ALPK1 binds ADP-heptose (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696491", "l": "CNTF binds CNTFR complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1963578", "l": "SHC1 binds phosphorylated ERBB2 heterodimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787737", "l": "CSF3R binds CSF3 dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53200", "l": "17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 17beta,19-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64931", "l": "dADP + H2O <=> dAMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25542", "l": "diphosphate + ent-pimara-8(14),15-diene => ent-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28825", "l": "H(+)(out) + L-galactonate(out) => H(+)(in) + L-galactonate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084505", "l": "Laminins bind HSPG2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5263633", "l": "DYSF, CAV3 and TRIM72 bind (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004076", "l": "biotin synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35417", "l": "an anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside + H(+) + UDP => an anthocyanidin 3-O-beta-D-sambubioside + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5688797", "l": "ATXN3 family cleave Ub chains (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48449", "l": "H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18173", "l": "(2R)-1-(4-hydroxyphenyl)-2-aminoethanol = (4-hydroxyphenyl)acetaldehyde + NH4(+)"}, {"i": "EC:4.2.1.87", "l": "\"Octopamine dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374173", "l": "AGT(34-41) binds to AGTR1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32289", "l": "(2S)-2-isopropylmalate => (2R,3S)-3-isopropylmalate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016303", "l": "1-phosphatidylinositol-3-kinase activity"}, {"i": "RHEA:12709", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)"}, {"i": "EC:2.7.1.137", "l": "\"Phosphatidylinositol 3-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912379", "l": "Transport of fringe-modified NOTCH to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25938", "l": "8-methylquinolin-2(1H)-one + AH2 => 8-methylquinoline + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31448", "l": "6-amino-2-oxohexanoate + H2O2 => 5-aminopentanoate + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702638", "l": "tandutinib-resistant FLT3 mutants don't bind tandutinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28687", "l": "(S)-dihydroorotate + ubiquinone-8 = orotate + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56689", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 => (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097162", "l": "MADS box domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5144542", "l": "CLOCK acetylates lysine-15 of histone H3, H4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12614", "l": "2 glutathione + L-cystine => glutathione disulfide + 2 L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375155", "l": "Interaction of NCAM1 with agrin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49535", "l": "4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O <=> ethylene glycol + H(+) + terephthalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187332", "l": "Cytosolic CMs translocate to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30108", "l": "D-serine + NADP(+) => 2-aminomalonate semialdehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674140", "l": "PAQR3 binds inactive RAFs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045552", "l": "dihydrokaempferol 4-reductase activity"}, {"i": "RHEA:23016", "l": "(2R,3S,4S)-3,4-leucopelargonidin + NADP(+) = (2R,3R)-dihydrokaempferol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008184", "l": "glycogen phosphorylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37124", "l": "sphing-4-enine + tetracosenoyl-CoA => CoA + H(+) + N-(tetracosenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48017", "l": "4-methyl-5-nitrocatechol + NADH + O2 => 2-hydroxy-5-methylquinone + H(+) + H2O + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47807", "l": "epothilone C + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> epothilone A + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54115", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + selina-4(15),7(11)-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36591", "l": "(S)-2-chloropropanoate + NADP(+) = 2-chloroacrylate + H(+) + NADPH"}, {"i": "EC:1.3.1.103", "l": "\"2-haloacrylate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64056", "l": "(1S,2R)-ephedrine + NAD(+) = (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19571", "l": "5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine => 5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191656", "l": "Closure of gap junction (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73797", "l": "FAICAR => IMP + H2O (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63529", "l": "[thioredoxin]-dithiol + H2O2 => [thioredoxin]-disulfide + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40990", "l": "EDTA + 2 FMNH2 + 2 O2 <=> ethylenediaminediacetate + 2 FMN + 2 glyoxylate + 3 H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42251", "l": "butanoyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxohexanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9619376", "l": "CAMK1 binds calmodulin (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700646", "l": "ASP-3026- resistant ALK mutants don't bind ASP-3026 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17887", "l": "acetylene + H2O => acetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246693", "l": "APC is K63-polyubiquitinated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247922", "l": "GGCT transforms gGluCys to OPRO (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102860", "l": "1-18:1-2-18:2-phosphatidylcholine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27633", "l": "ethylene glycol + NAD(+) <=> glycolaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42368", "l": "dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.124", "l": "\"Dihydromonacolin L hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38657", "l": "D-glucose + tulipalin B => 6-tuliposide B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55094", "l": "H(+) + sucrose + UDP => D-fructose + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-507875", "l": "Aquaporins passively transport urea into cells (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32263", "l": "4-aminobutanoate + pyruvate = L-alanine + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22885", "l": "glyoxylate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10307", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP] <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665871", "l": "ADRM1 binds 26S proteasome (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-398184", "l": "LARG activation by G alpha 12/13 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18470", "l": "an acyl-CoA + L-glutamine => an N(2)-acyl-L-glutamine + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29650", "l": "alpha-maltopentaose + phosphate <=> alpha-D-glucose 1-phosphate + alpha-maltotetraose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24336", "l": "a carboxylate + ATP + CoA = AMP + an acyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177942", "l": "EGFR binds EGF ligand (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57280", "l": "a guanosine in RNA + glyoxal = an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37338", "l": "5,6-dihydrothymine + H2O <=> 3-(carbamoylamino)-2-methylpropanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69068", "l": "RFC dissociates after sliding clamp formation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034789", "l": "2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53250", "l": "3beta-hydroxycholest-5-en-7-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesta-5,7-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944215", "l": "Association of procollagen type XX (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26377", "l": "GTP = cyclic pyranopterin phosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031405", "l": "lipoic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46255", "l": "2 [Fe(II)-cytochrome b5] + a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60515", "l": "a guanosine in miRNA + S-adenosyl-L-methionine <=> an N(7)-methylguanosine in miRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20261", "l": "3,5,7-trioxododecanoyl-CoA = CO2 + CoA + olivetol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017020", "l": "myosin phosphatase regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35008", "l": "D-fucose(in) => D-fucose(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016250", "l": "N-sulfoglucosamine sulfohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52597", "l": "lithocholoyl-CoA + NAD(+) => 3-oxocholan-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44812", "l": "1,4-dihydroxy-2-naphthoate + all-trans-undecaprenyl diphosphate + H(+) = 2-demethylmenaquinol-11 + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19426", "l": "H(+) + imidazole-4-acetate + NADH + O2 => 5-hydroxyimidazole-4-acetate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47767", "l": "S-adenosyl-L-methionine + uridine(1369) in 16S rRNA <=> 2'-O-methyluridine(1369) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909552", "l": "Phosphorylation of STAT1 at Ser727 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66661", "l": "ATP + beta-D-glucosylceramide(in) + H2O => ADP + beta-D-glucosylceramide(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13952", "l": "H(+) + NADP(+) + 2 reduced [rubredoxin] <=> NADPH + 2 oxidized [rubredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54994", "l": "2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 3 AH2 + CO2 + H(+) => 3 A + FMN + H2O + L-glutamate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944246", "l": "Association of procollagen type XXI (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45646", "l": "H(+) + N-hexadecanoylsphing-4-enine + phosphocholine => H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45767", "l": "H2O + L-aspartate 4-semialdehyde + NAD(+) <=> 2 H(+) + L-aspartate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23536", "l": "alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42359", "l": "(9Z)-tetradecenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(11Z)-hexadecenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018573", "l": "NOTCH3 binds activated EGFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15922", "l": "2 a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol => a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a 1,2-diacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51296", "l": "a quinone + H2O + L-methionyl-[protein] = a quinol + L-methionyl-(R)-S-oxide-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48003", "l": "1,6-dihydro-beta-NADP + H(+) + O2 <=> H2O2 + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45078", "l": "(9Z,12Z)-18-hydroxyoctadecadienoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015668", "l": "type III site-specific deoxyribonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40087", "l": "22-hydroxydocosanoate + NAD(+) = 22-oxodocosanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848975", "l": "PTK6 phosphorylates KHDRBS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38610", "l": "2'-phospho-cyclic ADP-ribose + nicotinate <=> nicotinate-adenine dinucleotide phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53518", "l": "(11Z,14Z,17Z-eicosatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53476", "l": "1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (6Z,9Z,12Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25033", "l": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH"}, {"i": "EC:1.1.1.300", "l": "\"NADP-retinol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1011598", "l": "DOCKs bind to RhoGEFs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21755", "l": "all-trans-violaxanthin <=> all-trans-capsorubin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112437", "l": "Formation of NELF complex  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662606", "l": "MT3 binds zinc (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170159", "l": "Translocation of Cdc25 to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090353", "l": "polygalacturonase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956676", "l": "YAP1 binds TP73 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63944", "l": "a fatty acyl-CoA + sphinga-4E,14Z-dienine = an N-acyl-sphinga-4E,14Z-dienine + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51391", "l": "acetyl-CoA + dopamine <=> CoA + H(+) + N-acetyl-dopamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30504", "l": "H2O + N-acetyl-L-glutamate 5-semialdehyde => acetate + L-glutamate 5-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44842", "l": "CoA + O-octadecanoyl-(R)-carnitine => (R)-carnitine + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48218", "l": "(2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31554", "l": "presqualene diphosphate <=> 15-cis-4,4'-diapophytoene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876789", "l": "CARNMT1 methylates CARN to Anserine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62540", "l": "2 [Fe(II)cytochrome c] + 3 H(+) + ouabain = 2 [Fe(III)cytochrome c] + dihydroouabain"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58237", "l": "L-tyrosyl-[protein] + NAD(+) => H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16981", "l": "3-oxoadipate + NAD(+) = H(+) + maleylacetate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031928", "l": "pyridoxine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27895", "l": "3'-CMP + H2O => cytidine + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050538", "l": "N-carbamoyl-L-amino-acid hydrolase activity"}, {"i": "RHEA:17581", "l": "an N-carbamoyl-L-2-amino acid + 2 H(+) + H2O = an L-alpha-amino acid + CO2 + NH4(+)"}, {"i": "EC:3.5.1.87", "l": "\"N-carbamoyl-L-amino-acid hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20309", "l": "2 H2O2 = 2 H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.180"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13180", "l": "6-phospho-5-dehydro-2-deoxy-D-gluconate <=> 3-oxopropanoate + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109701", "l": "PDPK1 binds PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41414", "l": "1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+) => 1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71303", "l": "RPE dimers isomerise RU5P to XY5P (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102516", "l": "delphinidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity"}, {"i": "MetaCyc:RXN-14448"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622382", "l": "PIP2 hydrolysis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264435", "l": "Dissociation of the COP1-p53 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264458", "l": "Proteasome mediated degradation of COP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031996", "l": "thioesterase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781899", "l": "USP13 binds SIAH2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32529", "l": "N-acetyl-alpha-D-glucosamine 1-phosphate + N-acetyl-D-glucosamine => N,N'-diacetylchitobiose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.137", "l": "\"2-acyl-4-prenylphloroglucinol 6-prenyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21758", "l": "dopamine + secologanin => deacetylisoipecoside + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35836", "l": "2'-dehydrokanamycin A + H(+) + NADPH => kanamycin A + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030941", "l": "chloroplast targeting sequence binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2201338", "l": "TRAF3 binds TICAM1:activated TLR4 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000120", "l": "CBLIF binds Cbl (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51980", "l": "an L-N,N-dihydroxypolyhomomethionine + H(+) = an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26388", "l": "all-trans-8'-apo-beta-carotenal + O2 <=> (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.20"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58179", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADPH <=> all-trans-lycopaoctaene + 2 diphosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030337", "l": "DNA polymerase processivity factor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47569", "l": "ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose => ganglioside GD1b (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51770", "l": "4-prenylphlormethylbutanophenone + diphosphate => 2-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one + dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60458", "l": "3',3'-cUAMP + 2 diphosphate => ATP + UTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10294", "l": "CoA + H(+) + N-acetyl-D-glucosamine 6-phosphate => acetyl-CoA + D-glucosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033745", "l": "L-methionine-(R)-S-oxide reductase activity"}, {"i": "RHEA:21260", "l": "[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (R)-S-oxide"}, {"i": "EC:1.8.4.14", "l": "\"L-methionine (R)-S-oxide reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.58"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65922", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine => L-kynurenine + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043325", "l": "phosphatidylinositol-3,4-bisphosphate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426489", "l": "RISC binds inexactly matching target RNAs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426209", "l": "DAG activation of TRPC channels (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59658", "l": "D-cellotriono-1,5-lactone + H2O2 => D-cellotriose + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31253", "l": "(S)-3-hydroxy-2-methylpropanoate + CoA + H(+) => (S)-3-hydroxyisobutanoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43917", "l": "(25R)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647631", "l": "GSDMD (1-275) binds PIPs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047728", "l": "carnitine 3-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33484", "l": "an acyl-CoA + ergosterol => CoA + ergosteryl ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41615", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O <=> D-ribose 2,5-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38253", "l": "CoA + hexadecanyl octadecanoate => hexadecan-1-ol + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605717", "l": "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62975", "l": "acetyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 3 CO2 + 4 CoA + orsellinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034543", "l": "5-aminosalicylate dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9604308", "l": "NICD4 traffics to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "65.827035527750795", "identifiers": [{"i": "GO:0036094", "l": "small molecule binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668023", "l": "TPST1,2 transfer SO4(2-) from PAPS to FVIII (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42154", "l": "a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acyl-(4R)-4-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37727", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938034", "l": "NR4A3 gene expression is stimulated by RUNX1:CBFB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390649", "l": "CHRM1,3,5 bind acetylcholine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11358", "l": "AH2 + NAD(+) => A + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41697", "l": "1-O-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417820", "l": "P2Y9 receptor can bind to LPA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.33", "l": "\"Peptidyl-Asp metalloendopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59519", "l": "acetylsalicylate + L-lysyl-[protein] <=> H(+) + N(6)-acetyl-L-lysyl-[protein] + salicylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27894", "l": "3'-CMP + H2O = cytidine + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140681", "l": "histone H3-tri/dimethyl-lysine-36 demethylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56802", "l": "cob(II)yrinate a,c diamide--[corrinoid adenosyltransferase] => apo-[corrinoid adenosyltransferase] + cob(II)yrinate a,c diamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66131", "l": "2-oxobutanoate + L-phenylalanine <=> (2S)-2-aminobutanoate + 3-phenylpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34553", "l": "ADP + cob(II)yrinate a,c diamide + H(+) + L-glutamate + phosphate => ATP + cob(II)yrinate c monoamide + H2O + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58441", "l": "N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine => 3 H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102802", "l": "thebaine 6-O-demethylase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018831", "l": "5-chloro-1,2,4-trihydroxybenzene dechlorinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15434", "l": "(2S)-naringenin + dimethylallyl diphosphate => diphosphate + sophoraflavanone B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1226012", "l": "Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61564", "l": "a tetracycline + H(+) + NADPH + O2 = a (1S,10aS)-3-(CONH2)-1-(Me2N)-3,3a,4,6-(HO)4-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracene + CO + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16152", "l": "beta-nicotinamide D-ribonucleotide + diphosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46276", "l": "(S)-malate + H(+) = (S)-lactate + CO2"}, {"i": "EC:4.1.1.101", "l": "\"Malolactic enzyme\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.-.-.-", "l": "\"Hydrolases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952749", "l": "STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034814", "l": "7,8-dihydroxy benzo(a)pyrene dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17161", "l": "2,6-dioxo-6-phenylhexa-3-enoate + H2O = 2-oxopent-4-enoate + benzoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937807", "l": "SRC phosphorylates RUNX3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43931", "l": "pregn-5-ene-3,20-dione <=> progesterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66097", "l": "3-phenylpyruvate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63262", "l": "4-pyridoxate + NAD(+) => 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62072", "l": "D-galactose 6-phosphate + NADP(+) = 6-phospho-D-galactono-1,5-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610327", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN3B (GRIN3B) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604732", "l": "Autocatalytic activation of proMMP13 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56675", "l": "dihydro-4-coumaroyl-CoA + NADP(+) <=> (E)-4-coumaroyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21611", "l": "isoliquiritigenin + S-adenosyl-L-methionine <=> 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322427", "l": "Beta-catenin recruits CBP/p300 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663511", "l": "BIL binds GSTA1, FABP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203716", "l": "eNOS:Caveolin-1 complex binds to Nostrin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483087", "l": "PI is exchanged with PC by PITPNB (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31061", "l": "2 H(+) + imidazole-4-acetate + NADH => H2O + imidazole-4-acetaldehyde + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62463", "l": "3,4-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] <=> 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050007", "l": "isonocardicin synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112435", "l": "Formation of Elongin BC complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51773", "l": "dimethylallyl diphosphate + phlorisobutanophenone => 4-prenylphlorisobutanophenone + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38178", "l": "all-trans-retinol + hexadecanoyl-CoA <=> all-trans-retinyl hexadecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18538", "l": "H2O + NAD(+) + salicylaldehyde => 2 H(+) + NADH + salicylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51778", "l": "deoxycohumulone + diphosphate => 4-prenylphlorisobutanophenone + dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64089", "l": "acetyl-CoA + 9 H(+) + holo-[ACP] + 9 malonyl-CoA => 3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 9 CO2 + 10 CoA + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26226", "l": "abieta-7,13-dien-18-al + H2O + NAD(+) => abieta-7,13-dien-18-oate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004465", "l": "lipoprotein lipase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40924", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432162", "l": "Unblocking of GRIN1:GRIN2 NMDA receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380930", "l": "Phosphorylated AMPK binds AMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12425", "l": "(3S)-3-hydroxy-L-aspartate => NH4(+) + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0001595", "l": "angiotensin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50664", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222376", "l": "NOX2 generates superoxide from oxygen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205682", "l": "Parkin promotes the ubiquitination of mitochondrial substrates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917841", "l": "Acidification of Tf:TfR1 containing endosome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14387", "l": "dolichyl phosphate + H(+) + phosphate => dolichyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38421", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate => 1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40649", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16084", "l": "(2R)-S-methyl-3-phospho-1-thioglycerate + H2O <=> (2R)-S-methyl-1-thioglycerate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61305", "l": "N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose => H(+) + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19961", "l": "a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate = a 2'-deoxyribonucleoside 5'-phosphate + a ribonucleoside"}, {"i": "EC:2.7.1.77", "l": "\"Nucleoside phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "74.603620314006946", "identifiers": [{"i": "GO:1901265", "l": "nucleoside phosphate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29979", "l": "2'-deoxyadenosine(in) + H(+)(in) = 2'-deoxyadenosine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42428", "l": "clavaminate = (3R,5R)-clavulanate-9-aldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400143", "l": "Fatty acid ligands activate PPARA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5226979", "l": "ADD1:ADD2 binds DMTN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1299338", "l": "Activation of TRESK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-141437", "l": "Formation of the MCC complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034246", "l": "mitochondrial transcription factor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0032027", "l": "myosin light chain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49557", "l": "H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] => H(+) + L-cysteinyl-[protein] + lactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22713", "l": "adenosylcob(III)inamide phosphate + GTP + H(+) => adenosylcob(III)inamide-GDP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36110", "l": "gibberellin A4 + S-adenosyl-L-methionine <=> O-methyl gibberellin A4 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39729", "l": "a sphingomyelin(out) => a sphingomyelin(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63742", "l": "2-phenylethanol + NAD(+) => 2-phenylacetaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62670", "l": "H2O + herqueinone + NADP(+) => deoxyherqueinone + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085992", "l": "SUMOylation of DAXX with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854222", "l": "TBC1D3 associates with RAB5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52257", "l": "a 7(1)-hydroxybacteriochlorophyllide c + H2O + S-adenosyl-L-methionine => 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide c + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74258", "l": "XDH oxidizes xanthine to form urate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5669240", "l": "FLNA binds PAK1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204600", "l": "Basigin homodimerises (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10569", "l": "luteolin + UDP-alpha-D-glucuronate => H(+) + luteolin 7-O-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57681", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] => a flavone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40848", "l": "eicosanoyl-CoA + FAD + H(+) => (2E)-eicosenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29329", "l": "(S)-malate(out) + succinate(in) => (S)-malate(in) + succinate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49068", "l": "25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1,25-dihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37811", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34446", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose <=> CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.14"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19253", "l": "a sphingomyelin + H2O = an N-acylsphing-4-enine + H(+) + phosphocholine"}, {"i": "EC:3.1.4.12", "l": "\"Sphingomyelin phosphodiesterase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102056", "l": "11-hydroxyjasmonate sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51253", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080032", "l": "methyl jasmonate esterase activity"}, {"i": "MetaCyc:RXN-10767"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983700", "l": "SYK binds the activated BCR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20164", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + sucrose <=> myo-inositol + raffinose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043838", "l": "phosphatidylethanolamine:Kdo2-lipid A phosphoethanolamine transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411402", "l": "Activation of NLK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60447", "l": "an S-substituted L-cysteinylglycine + H2O <=> an S-substituted L-cysteine + glycine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008670", "l": "2,4-dienoyl-CoA reductase (NADPH) activity"}, {"i": "RHEA:12136", "l": "a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) = a (2E,4E)-dienoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3785704", "l": "DSB inducing agents induce double strand DNA breaks (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55078", "l": "3-methylsulfanylpropanal + CO2 => 4-methylsulfanyl-2-oxobutanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29671", "l": "Ca(2+)(in) = Ca(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "74.159372409045062", "identifiers": [{"i": "GO:0030546", "l": "signaling receptor activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444691", "l": "Prokineticin receptors bind prokineticin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52115", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA <=> 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63619", "l": "prunetin + UDP-alpha-D-glucuronate <=> H(+) + prunetin-C(8)-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39881", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + a 2,3-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35390", "l": "precorrin-7 + S-adenosyl-L-methionine <=> 2 H(+) + precorrin-8X + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14019", "l": "ADP + beta-nicotinamide D-ribonucleotide + H(+) => ATP + beta-nicotinamide D-riboside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16787", "l": "an N(6)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine => an adenosine in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171059", "l": "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49396", "l": "20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56171", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389350", "l": "Activation of Cdc42 by pVav1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.349", "l": "\"Toxoflavin synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106378", "l": "2-hydroxy-dATP hydrolase activity"}, {"i": "RHEA:31583", "l": "2-hydroxy-dATP + H2O = 2-hydroxy-dAMP + diphosphate + H(+)"}, {"i": "EC:3.6.1.56", "l": "\"2-hydroxy-dATP diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2197770", "l": "STAB1 (FEEL-1) binds ligands (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47036", "l": "uridine in 5S rRNA = pseudouridine in 5S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66283", "l": "solanidine + UDP-alpha-D-glucose <=> H(+) + solanidine 3-O-beta-D-glucopyranoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65160", "l": "benzoyl-CoA + hexan-2-ol = CoA + hexan-2-yl benzoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70420", "l": "HK1,2,3,GCK phosphorylate Glc to form G6P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66087", "l": "L-kynurenine + oxaloacetate <=> H2O + kynurenate + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40653", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+) => 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44845", "l": "(R)-carnitine + eicosanoyl-CoA => CoA + O-eicosanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0034061", "l": "DNA polymerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54096", "l": "N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50377", "l": "a ceramide(in) + ATP + H2O => a ceramide(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052381", "l": "tRNA dimethylallyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198314", "l": "DAG stimulates protein kinase C-delta (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035925", "l": "mRNA 3'-UTR AU-rich region binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682718", "l": "nsp15 forms a hexamer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22126", "l": "acetate + ajmaline + H(+) => 17-O-acetylajmaline + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45884", "l": "12-methyloctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(11-methylheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37550", "l": "D-glucose 6-phosphate + NAD(+) <=> 3-dehydro-D-glucose 6-phosphate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36389", "l": "6''-O-carbamoylkanamycin A + AMP + H(+) => carbamoyl adenylate + kanamycin A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66681", "l": "ATP + coproporphyrinogen III(in) + H2O => ADP + coproporphyrinogen III(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48156", "l": "ganglioside GQ1b (d18:1(4E)) + H2O = ganglioside GT1b (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004427", "l": "inorganic diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36723", "l": "2-phenylethylamine + A + H2O = 2-phenylacetaldehyde + AH2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23509", "l": "(7R)-7-(4-carboxybutanamido)cephalosporanate + H2O => (7R)-7-aminocephalosporanate + glutarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54309", "l": "pseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66620", "l": "5alpha-cholest-7-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (25S)-Delta7-dafachronate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41781", "l": "beta-D-Gal-(1<->1')-Cer + CMP-N-acetyl-beta-neuraminate => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1454916", "l": "The ABCC family mediates organic anion transport (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57379", "l": "(S)-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-1-hydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62550", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + H(+) + UDP => a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57579", "l": "7-deoxyloganate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + loganate + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67153", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[NO transferase protein] => L-cysteinyl-[NO transferase protein] + S-nitroso-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19814", "l": "a 2-oxocarboxylate + L-asparagine => 2-oxosuccinamate + an L-alpha-amino acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244397", "l": "botB HC:LC binds SYT1 or 2 and GT1b on the target cell surface (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8873946", "l": "OTUD3 deubiquitinates PTEN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9032798", "l": "DOCK3 activates RAC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60275", "l": "N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64182", "l": "a fatty acid + L-tryptophan => an N-(fatty acyl)-L-tryptophan + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42985", "l": "(+)-copalyl diphosphate => diphosphate + pimara-8(14),15-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20774", "l": "5-amino-6-(D-ribitylamino)uracil + riboflavin => 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52127", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25285", "l": "O2 + reduced [NADPH--hemoprotein reductase] + squalene <=> (S)-2,3-epoxysqualene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102850", "l": "1-18:1-2-16:0-phosphatidylglycerol omega-6 desaturase activity"}, {"i": "RHEA:46376", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.19.23", "l": "\"Acyl-lipid (n+3)-(Z)-desaturase (ferredoxin)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24926", "l": "L-homoserine <=> 2-oxobutanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "78.423603998002051", "identifiers": [{"i": "GO:0042910", "l": "xenobiotic transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848414", "l": "Activated PTK6 binds CDKN1B (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65369", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O => a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21225", "l": "CDP-choline + sphing-4-enine => CMP + H(+) + sphing-4-enine-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35155", "l": "(S)-4,5-dihydroxypentane-2,3-dione = (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432897", "l": "ILK interacts with beta-1 integrin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050394", "l": "viomycin kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176116", "l": "Recruitment and activation of Chk1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174916", "l": "Formation of N-glucuronides (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59017", "l": "4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + NAD(+) => CO2 + cycloeucalenone + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55204", "l": "5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)"}, {"i": "EC:4.3.1.32", "l": "\"7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9612509", "l": "SGK phosphorylates SRF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592297", "l": "Full activation of MMP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008012", "l": "structural constituent of adult chitin-based cuticle"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61467", "l": "a cytidine in mRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373717", "l": "DCC interacts with DIP13alpha (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106313", "l": "methylenetetrahydrofolate reductase NADPH activity"}, {"i": "RHEA:19817", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH"}, {"i": "EC:1.5.1.20", "l": "\"Methylenetetrahydrofolate reductase (NAD(P)H)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797961", "l": "CHDH oxidises Cho to BETALD (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354173", "l": "Activation of Rap1 by cytosolic GEFs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31662", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GlcpNAc + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10978", "l": "5,6-dihydroquinoline-2,5,6-triol + NAD(+) => H(+) + NADH + O2 + quinolin-2-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40093", "l": "26-oxohexacosanoate + H(+) + NADH => 26-hydroxyhexacosanoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65281", "l": "alpha-NeuNAc-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1<->1')-L-Ser-[protein] + CMP-N-acetyl-beta-neuraminate => alpha-NeuNAc-(2->3)-beta-D-Gal-(1->3)-[alpha-NeuNAc-(2->6)]-alpha-D-GalNAc-(1<->1')-L-Ser-[protein] + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445091", "l": "Phosphorylation of Neurofascin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54945", "l": "3-oxo-(5Z)-dodecenoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-(5Z)-dodecenoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63335", "l": "alpha-L-arabinose <=> beta-L-arabinose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46449", "l": "2 L-tyrosyl-tRNA(Tyr) => cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41201", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate => 1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57065", "l": "D-apionolactone + H2O => D-apionate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390593", "l": "ATP Hydrolysis By Myosin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49773", "l": "glycine + hexacosanoyl-CoA => CoA + H(+) + N-hexacosanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34299", "l": "2'-deamino-2'-hydroxyneamine + 2-oxoglutarate = 2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate"}, {"i": "EC:2.6.1.94", "l": "\"2'-deamino-2'-hydroxyneamine transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218820", "l": "Src kinases phosphorylate VAV (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445079", "l": "Phosphorylation of L1 by ERK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-996755", "l": "ZFPM proteins bind GATA proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687083", "l": "MYC binds MAPKAPK5 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6802973", "l": "PLK3 phosphorylates CDC25C (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62634", "l": "an alcohol + glutathione disulfide + H2O => a hydroperoxide + 2 glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36532", "l": "(13Z)-docosenoyl-CoA + H(+) + malonyl-CoA => (15Z)-3-oxotetracosenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "81.790986234327661", "identifiers": [{"i": "GO:0016409", "l": "palmitoyltransferase activity"}, {"i": "REACT:R-HSA-203567", "l": "palmitoylation of eNOS (Homo sapiens)"}, {"i": "REACT:R-HSA-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11138", "l": "a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675198", "l": "Activated MAPKs phosphorylate BRAF (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62338", "l": "adenosine 3'-diphosphate,5'-phosphate + AMP + H(+) => AMP + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16491", "l": "D-glucose + mandelonitrile => (R)-prunasin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61588", "l": "amicoumacin A + ATP = ADP + amicoumacin A 2-phosphate + H(+)"}, {"i": "EC:2.7.1.230", "l": "\"Amicoumacin kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42740", "l": "guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.173", "l": "\"23S rRNA (guanine(2445)-N(2))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48744", "l": "(-)-yatein + 2-oxoglutarate + O2 = (-)-deoxypodophyllotoxin + CO2 + H2O + succinate"}, {"i": "EC:1.14.20.8", "l": "\"(-)-deoxypodophyllotoxin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11378", "l": "4,21-dehydrogeissoschizine + NADPH => (19S)-geissoschizine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66010", "l": "[collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O => (5R)-5-hydroxy-L-lysyl-[collagen] + H2O2 + L-methionyl-[collagen]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32171", "l": "H(+) + NADPH + O2 + phenylacetyl-CoA = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+)"}, {"i": "EC:1.14.13.149", "l": "\"Phenylacetyl-CoA 1,2-epoxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112727", "l": "Serine phosphorylation of STATs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0008746", "l": "NAD(P)+ transhydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59040", "l": "4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 = 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38281", "l": "(3R)-citramalyl-CoA + succinate => (3R)-citramalate + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34547", "l": "ATP + cob(II)yrinate + H2O + L-glutamine = ADP + cob(II)yrinate c monoamide + H(+) + L-glutamate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16829", "l": "an aldehyde + H2O + O2 = a carboxylate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51192", "l": "(R)-2-hydroxyglutarate + NADP(+) = 2-oxoglutarate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24247", "l": "NADP(+) + pseudotropine <=> H(+) + NADPH + tropinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53710", "l": "(2E,4Z)-decadienoyl-CoA + H(+) + NADPH => (2E)-decenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39463", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA = (2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72647", "l": "Cap-bound mRNA is activated by helicases  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674093", "l": "PDGFRs bind type I TKI (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018772", "l": "trioxoheptanoate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30908", "l": "(S)-3-methyl-2-oxopentanoate + CoA + NAD(+) => 2-methylbutanoyl-CoA + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33058", "l": "guanosine 3'-diphosphate 5'-triphosphate + H2O <=> diphosphate + GTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53405", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => 13-hydroxy-(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5689000", "l": "AADAC deacetylates PHEN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56248", "l": "1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = 2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3149492", "l": "cob(II)alamin dissociates from MMACHC:MMADHC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52473", "l": "16alpha,17beta-estriol + UDP-alpha-D-glucuronate => 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183072", "l": "EGFR non-clathrin mediated endocytosis (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3858482", "l": "DVL is recruited to the receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3364042", "l": "APC promotes disassembly of beta-catenin transactivation complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11361", "l": "2 2',3,4,4',6'-pentahydroxychalcone + 2 H(+) + O2 => 2 aureusidin + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65506", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + [mycofactocin precursor peptide]-C-terminal glycine => [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685296", "l": "GATA6 binds SFTPA genes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0017171", "l": "serine hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31569", "l": "2,2-bis(4-hydroxyphenyl)-1-propanol + H2O + NAD(+) => bisphenol A + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703433", "l": "Ligand-independent dimerization of FLT3 fusion proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862700", "l": "CMKLR1 binds Resolvin E1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64296", "l": "(4S,8R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,16,19-heptaen-18-one + H(+) + NADPH = (4S,8R,16R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,19-hexaen-18-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17415", "l": "an N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25352", "l": "H2O + L-cysteinyl-tRNA(Pro) => H(+) + L-cysteine + tRNA(Pro)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216202", "l": "Phosphorylated SMO changes conformation and is activated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.153", "l": "\"Fructan beta-(2,1)-fructosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193801", "l": "Influx of 27-hydroxycholesterol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2130706", "l": "MHC class II antigen processing (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10530", "l": "10-hydroxydihydrosanguinarine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dihydrosanguinarine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35091", "l": "anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine = 2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:6.3.2.40", "l": "\"Cyclopeptine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55119", "l": "5-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-5-methylhexanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389491", "l": "Two NPFF receptors can bind neuropeptide FF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31867", "l": "(S)-2,3-epoxysqualene = baccharis oxide"}, {"i": "EC:5.4.99.51", "l": "\"Baccharis oxide synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428888", "l": "Phosphorylation of ROBO1 by ABL kinase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70427", "l": "PGM:Mg2+ isomerise G1P to G6P (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54321", "l": "2 [Fe(II)-cytochrome b5] + a Delta(7)-sterol + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a Delta(5),Delta(7)-sterol + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977250", "l": "Autophosphorylation of IRAK4 bound to activated TLR5 or 15 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.270", "l": "\"3-beta-hydroxysteroid 3-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.45"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35664", "l": "a 1,2-diacyl-sn-glycerol + H2O => a 1-acyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62875", "l": "(3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + H(+) + NADPH + O2 <=> H2O + NADP(+) + semiviriditoxin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112379", "l": "Recruitment of elongation factors to form elongation complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66267", "l": "ATP + H(+) + nonanoate <=> diphosphate + nonanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38788", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15738", "l": "cyclopentanone + H(+) + NADPH + O2 => 5-valerolactone + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047227", "l": "indolylacetyl-myo-inositol galactosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32188", "l": "cholest-5-en-3-one => cholest-4-en-3-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008696", "l": "IL37(?-218) translocates from the cytosol to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209828", "l": "Tryptophan is hydroxylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1454928", "l": "ABCG4 may mediate cholesterol efflux (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202960", "l": "Caspase mediated cleavage of C-IAP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141409", "l": "Mad1 binds kinetochore (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30330", "l": "beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-zeaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55123", "l": "4-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-4-methylhexanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11271", "l": "D-cysteine + H2O <=> H(+) + hydrogen sulfide + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173680", "l": "Activation of C5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218811", "l": "DOCK180:ELMO binds CRK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24104", "l": "7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine"}, {"i": "EC:2.4.2.29", "l": "\"tRNA-guanosine(34) preQ(1) transglycosylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75187", "l": "TRAIL:TRAIL receptor trimers bind FADD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36208", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an acyl-CoA => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6804724", "l": "MDM2 ubiquitinates phosphorylated MDM4 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614271", "l": "Autocleavage of ADGRG6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176956", "l": "Formation of GINS complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21318", "l": "butanoate + H(+) + phorbol 13-butanoate => H2O + phorbol 12,13-dibutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009485", "l": "IL34:CSF1 binds CSF1R (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44644", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57303", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O <=> a 2'-deoxyguanosine in DNA + H(+) + lactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203613", "l": "depalmitoylation of eNOS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6785594", "l": "FANCD2 binds FANCI (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852324", "l": "GTSE1 binds PLK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45299", "l": "a sphingosylphosphocholine + H2O <=> a sphingoid base + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35977", "l": "A + CO2 + H2O + succinate + verruculogen => 2-oxoglutarate + AH2 + fumitremorgin B + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37766", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA <=> 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018618", "l": "anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35389", "l": "2 H(+) + precorrin-8X + S-adenosyl-L-homocysteine => precorrin-7 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34207", "l": "3-O-alpha-D-glucosyl-L-rhamnose + phosphate = beta-D-glucose 1-phosphate + L-rhamnopyranose"}, {"i": "EC:2.4.1.282", "l": "\"3-O-alpha-D-glucosyl-L-rhamnose phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59329", "l": "D-xylono-1,5-lactone + H2O => D-xylonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12564", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + NAD(+) = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34985", "l": "sulfate(out) => sulfate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34882", "l": "2 H2O + methyl 3-cyano-2-phenylpropanoate <=> 4-methoxy-4-oxo-3-phenylbutanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62464", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = 2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917696", "l": "Cargo Sequestration (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036163", "l": "3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid decarboxylase activity"}, {"i": "RHEA:44768", "l": "3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) = 2-methoxy-6-(all-trans-hexaprenyl)phenol + CO2"}, {"i": "KEGG.REACTION:R06866"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132276", "l": "Complement factor I inactivates C3b (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33075", "l": "3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine = 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine"}, {"i": "EC:2.5.1.120", "l": "\"Aminodeoxyfutalosine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25577", "l": "3 O2 + protoporphyrinogen IX => 3 H2O2 + protoporphyrin IX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43838", "l": "26-hydroxycholesterol + H2O + NADP(+) => cholesterol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694455", "l": "SUMO-p-N protein dimer binds genomic RNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39531", "l": "3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47331", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18999", "l": "CDP-choline + diphosphate => CTP + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102931", "l": "(Z,E)-alpha- farnesene synthase activity"}, {"i": "MetaCyc:RXN-8931"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168891", "l": "Binding of NS1 to dsRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47164", "l": "4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) = CO2 + NADH + zymosterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28743", "l": "nitrate(in) + nitrite(out) = nitrate(out) + nitrite(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11889", "l": "an aldehyde + H2O + NADP(+) => a carboxylate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30807", "l": "L-pipecolate + NAD(+) = Delta(1)-piperideine-2-carboxylate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015244", "l": "fluconazole transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070463", "l": "tubulin-dependent ATPase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28371", "l": "oxaloacetate + phosphate => hydrogencarbonate + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604368", "l": "Autocatalytic activation of bound proMMP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389862", "l": "Conversion of glyoxylate to oxalate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102150", "l": "3-oxo-myristoyl-CoA hydrolase activity"}, {"i": "MetaCyc:RXN-11668"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031740", "l": "type A cholecystokinin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20391", "l": "(2R,3R)-2,3-dihydrogossypetin + H2O + NADP(+) => (2R,3R)-dihydroquercetin + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937814", "l": "RUNX3 translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34999", "l": "ADP(in) + ATP(out) = ADP(out) + ATP(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24294", "l": "CoA + H(+) + N-acetyl-L-glutamate => acetyl-CoA + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34780", "l": "a 3alpha-hydroxysteroid + NAD(+) => a 3-oxosteroid + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61544", "l": "ent-kaur-16-en-19-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = ent-kaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48918", "l": "CMP + ganglioside GD1c + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1b"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876446", "l": "p-ULK1 phosphorylates DENND3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32577", "l": "(1R,5R)-alpha-pinene + diphosphate => (2E)-geranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169402", "l": "ISGylation of E2 conjugating enzymes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47531", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH <=> isocholate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015134", "l": "hexuronate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031746", "l": "type 1 cysteinyl leukotriene receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50025", "l": "dodecanoyl-CoA + H2O => adenosine 3',5'-bisphosphate + dodecanoyl-4'-phosphopantetheine + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27416", "l": "2-oxoglutarate + codeine + O2 <=> CO2 + formaldehyde + morphine + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2186771", "l": "RNF111 binds SMAD7 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449958", "l": "IL7:IL7R:JAK1 binds IL2RG:JAK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39393", "l": "(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+) => (2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.5.1", "l": "\"Sesamin methylene transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56255", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-seryl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33429", "l": "bacillithiol + H2O => (S)-malyl alpha-D-glucosaminide + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203553", "l": "eNOS binds NOSIP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26096", "l": "(4R)-limonene + H(+) + NADH + O2 <=> H2O + limonene 1,2-epoxide + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5576895", "l": "SCNAs:SNCBs transport Na+ from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56845", "l": "nocamycin E + S-adenosyl-L-methionine => nocamycin I + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665871", "l": "ADRM1 binds 26S proteasome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788622", "l": "p-Y-STATs dimerize (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045430", "l": "chalcone isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64583", "l": "(2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate <=> diphosphate + nerylneryl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3245898", "l": "TCN1 binds Cbl in the circulation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781814", "l": "USP19 deubiquitinates RNF123 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11052", "l": "4-aminobenzoate + 2 H(+) + NADH + O2 = 4-aminophenol + CO2 + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211239", "l": "Association of DFF40 with chromatin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870469", "l": "RGGT geranylgeranylates RAB proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2247511", "l": "STAB2:ligand is endocytosed (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072582", "l": "17-beta-hydroxysteroid dehydrogenase (NADP+) activity"}, {"i": "RHEA:24616", "l": "17beta-estradiol + NADP(+) = estrone + H(+) + NADPH"}, {"i": "EC:1.1.1.62", "l": "\"17-beta-estradiol 17-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33841", "l": "7-O-geranyl-2-O,3-dimethylflaviolin + diphosphate => (2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20511", "l": "ADP + H(+) + O-phosphoviomycin => ATP + viomycin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2870221", "l": "E-selectin binds E-selectin ligand (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61547", "l": "ent-kaur-16-en-19-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> ent-kaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59192", "l": "ATP + eicosanoate + H(+) = diphosphate + icosanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35502", "l": "11-oxo-beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> glycyrrhetinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53843", "l": "3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADP(+) <=> 7,12-dioxo-lithocholate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692794", "l": "p-S215 FOXO1 positively regulates RAG gene expression  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55639", "l": "ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O <=> AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46521", "l": "2 [Fe(II)-cytochrome b5] + an N-(1,2 saturated acyl)-(4R)-hydroxysphinganine + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + an N-(2R-hydroxyacyl)-4R-hydroxysphinganine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782685", "l": "EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31721", "l": "11-oxo-beta-amyrin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 11alpha-hydroxy-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168136", "l": "Activated JNKs phosphorylate c-JUN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036025", "l": "Defective MPDU1 does not promote transfer of Man to (GlcNAc)2 (Man)5 (PP-Dol)1 by ALG3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177926", "l": "Dephosphorylation of PAG by SHP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165195", "l": "GTP loading by Rheb (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55570", "l": "2 H(+) + psilocybin + 2 S-adenosyl-L-homocysteine => 4-hydoxytryptamine 4-phosphate + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17043", "l": "AMP + 2 H(+) + sulfate => adenosine 5'-phosphosulfate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9029680", "l": "Caspase-7 translocates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39481", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+) => (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42027", "l": "3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) <=> 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050733", "l": "RS domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018814", "l": "RHOT1 hydrolyzes GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61600", "l": "[DsbD protein]-disulfide + [protein]-dithiol = [DsbB protein]-dithiol + [protein]-disulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53605", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42149", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acyl-(4R)-4-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693598", "l": "ATM phosphorylates NBN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11408", "l": "H(+) + H2O + riboflavin = lumichrome + ribitol"}, {"i": "EC:3.5.99.1", "l": "\"Riboflavinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44071", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102603", "l": "12-demethyl-elloramycin C12a O-methyltransferase activity"}, {"i": "MetaCyc:RXN-15402"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008994", "l": "rhamnulose-1-phosphate aldolase activity"}, {"i": "MetaCyc:RHAMNULPALDOL-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389972", "l": "alpha-tubulin:GTP + Cofactor B -> alpha-tubulin:GTP: Cofactor B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.-", "l": "\"With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53254", "l": "5alpha-cholestan-7-oxo-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5alpha-cholest-7-en-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62784", "l": "2 fonsecin B + H(+) + NADPH + O2 = bifonsecin B + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390886", "l": "HRH4 binds Hist (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13092", "l": "6 [Fe(III)cytochrome c] + 2 H2O + NH4(+) <=> 6 [Fe(II)cytochrome c] + 8 H(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10956", "l": "(E)-cinnamate + H(+) + NADPH + O2 = H2O + NADP(+) + trans-2-coumarate"}, {"i": "EC:1.14.13.14", "l": "\"Trans-cinnamate 2-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047029", "l": "(R)-4-hydroxyphenyllactate dehydrogenase (NADPH) activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086078", "l": "gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63927", "l": "ATP + N(4)-acetylcytidine <=> ADP + H(+) + N(4)-acetylcytidine 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20548", "l": "H(+) + L-kynurenine + NADPH + O2 <=> 3-hydroxy-L-kynurenine + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42389", "l": "beta-D-glucosyl crocetin + UDP-alpha-D-glucose => beta-D-gentiobiosyl crocetin + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.162", "l": "\"N-acetylhexosamine 1-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.4.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28384", "l": "D-glucose 6-phosphate + L-lysine => H2O + N(6)-(6-phospho-D-fructosyl)-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40393", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + CoA => 1-O-alkyl-2-acyl-sn-glycerol + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57961", "l": "dimethyl sulfide + H(+) + NADH + O2 => dimethyl sulfoxide + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60996", "l": "H2O + L-leucine + O2 = 4-methyl-2-oxopentanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935730", "l": "RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the ITGA2B promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848124", "l": "PTK6 phosphorylates STAT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62181", "l": "H2O + peregrinol diphosphate => diphosphate + viteagnusin D"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65640", "l": "(4R)-hydroxysphing-(8Z)-enine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8Z)-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616241", "l": "CEBPA binds the promoter of the CEBPE gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55891", "l": "[aequorin]--dioxetanone <=> [excited state blue fluorescent protein] + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23416", "l": "(2R)-O-phospho-3-sulfolactate + H2O = (R)-3-sulfolactate + phosphate"}, {"i": "EC:3.1.3.71", "l": "\"2-phosphosulfolactate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24314", "l": "H(+) + N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine => L-lysyl-[cytochrome c] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32507", "l": "4-isopropenyl-7-methyloxepan-2-one + H2O = 6-hydroxy-3-isopropenylheptanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55645", "l": "ATP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] => ADP + C-terminal S-cyanate-L-cysteinyl-[HypE protein] + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102051", "l": "indole-3-acetyl-tryptophan synthetase activity"}, {"i": "MetaCyc:RXN-10433"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9611851", "l": "ADRB2 bind ADR,NAd (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28255", "l": "(3Z)-hex-3-en-1-ol + acetyl-CoA => (3Z)-hex-3-en-1-yl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10461", "l": "prostaglandin A1 => prostaglandin C1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34868", "l": "ATP + CoA + thiophene-2-carboxylate => AMP + diphosphate + thiophene-2-carbonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005124", "l": "scavenger receptor binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050085", "l": "mannitol 2-dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16912", "l": "2 [Fe(III)cytochrome c] + glycine + H2O <=> 2 [Fe(II)cytochrome c] + glyoxylate + 2 H(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55096", "l": "(3S)-3-hydroxypentanoyl-CoA + H2O = (3S)-3-hydroxypentanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390929", "l": "HTR1 and 5A receptors can bind serotonin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878117", "l": "RUNX3 binds ZFHX3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604732", "l": "Autocatalytic activation of proMMP13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56771", "l": "2 AH2 + all-trans-zeaxanthin + 2 O2 <=> 2 A + all-trans-adonixanthin + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9017507", "l": "RHOJ binds effectors at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33181", "l": "1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9650165", "l": "ASIC trimers bind H+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851979", "l": "BTNL9 binds immune cell surfaces (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14980", "l": "3-carboxy-2,5-dihydro-5-oxofuran-2-acetate <=> 3-carboxy-cis,cis-muconate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4167511", "l": "HLCS biotinylates ACACB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043801", "l": "hexulose-6-phosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-398184", "l": "LARG activation by G alpha 12/13 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24256", "l": "ATP + kanamycin A = ADP + H(+) + kanamycin 3'-phosphate"}, {"i": "EC:2.7.1.95", "l": "\"Kanamycin kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5660663", "l": "Caspase-8 cleaves IL1B precursor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49470", "l": "a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H(+) + UDP => a 1,2-diacyl-sn-glycerol + UDP-alpha-D-6-sulfoquinovose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38572", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) => a 1,2-diacyl-sn-glycero-3-phosphocholine(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047816", "l": "D-arabinose 1-dehydrogenase (NAD+) activity"}, {"i": "RHEA:20457", "l": "D-arabinose + NAD(+) = D-arabinono-1,4-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655263", "l": "Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392749", "l": "Transport of L1 into endosomes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9698408", "l": "PTPRJ dephosphorylates active FLT3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0050664", "l": "oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"}, {"i": "EC:1.6.3.-", "l": "\"With oxygen as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47839", "l": "[5-(aminomethyl)-3-furyl]methyl phosphate + ATP <=> [5-(aminomethyl)furan-3-yl]methyl diphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68611", "l": "Formation of ORC(1-5) complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9664850", "l": "ATM binds PEX5 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097429", "l": "amino acid ligation activity by nonribosomal peptide synthase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482770", "l": "Release of platelet secretory granule components (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9038545", "l": "miR-613 binds to the 3'UTR of the NR1H3 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021357", "l": "PRKCI phosphorylates ELF3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941895", "l": "Formation of CDK4/6:CCND complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28781", "l": "glycine + glycolaldehyde => 4-hydroxy-L-threonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375140", "l": "CDO binds promyogenic cadherins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13195", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate => 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34011", "l": "ergosta-5,7,24(28)-trien-3beta-ol + 2 H2O + NADP(+) = ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34611", "l": "N-acyl-15-methylhexadecasphing-4-enine + UDP-alpha-D-glucose = H(+) + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111238", "l": "Formation of ADAR2  homodimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047049", "l": "(R)-2-hydroxy-fatty acid dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168140", "l": "Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45662", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31195", "l": "(3S)-hydroxyoctanoyl-CoA + NAD(+) = 3-oxooctanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106386", "l": "(3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33863", "l": "menaquinone-7 + succinate = fumarate + menaquinol-7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33999", "l": "5alpha-cholesta-8,24-dien-3beta-ol = 5alpha-cholesta-7,24-dien-3beta-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624125", "l": "Formation of the BBSome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015539", "l": "hexuronate:cation symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66867", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + quiannulatene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24744", "l": "2-oxobutanoate + NH4(+) => 2-aminobut-2-enoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19315", "l": "an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+) => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432956", "l": "BP230 is recruited to the hemidesmosome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9737780", "l": "MTTP binds lomitapide (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31700", "l": "4 H(+) + 2 O2 + pentalenene + 4 reduced [2Fe-2S]-[ferredoxin] => 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48099", "l": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66713", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + stellata-2,6,19-triene => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + stellatate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797090", "l": "CCNK binds CDK12 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18357", "l": "NADP(+) + tropine = H(+) + NADPH + tropinone"}, {"i": "EC:1.1.1.206", "l": "\"Tropinone reductase I\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856525", "l": "ANGPTL8 binds ANGPTL3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31169", "l": "3-oxotetradecanoyl-CoA + H(+) + NADH => (3S)-hydroxytetradecanoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.28", "l": "\"Phenylethanolamine N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66876", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 12-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5683593", "l": "ATG7:ATG3:LC3 dissociates (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928610", "l": "PTK2 autophosphorylates at Y397 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451377", "l": "Interaction of IQGAP1 with nephrin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211919", "l": "CYP4F8 19-hydroxylates PGH2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83677", "l": "C4 deamination of cytidine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40257", "l": "(3R)-hydroxyhexadecanedioyl-CoA => (2E)-hexadecenedioyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-917841", "l": "Acidification of Tf:TfR1 containing endosome (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69068", "l": "RFC dissociates after sliding clamp formation (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45379", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450550", "l": "PKCalpha phosphorylates HuR (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47044", "l": "3-dehydrocarnitine + acetyl-CoA = acetoacetate + N,N,N-trimethylglycyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63797", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + H2O => C-terminal L-alpha-aminoacyl-[tubulin] + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38957", "l": "an N-acylsphing-4-enine 1-phosphate(out) => an N-acylsphing-4-enine 1-phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3782655", "l": "HDAC10 deacetylates histone (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141367", "l": "Myristoylation of tBID by NMT1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682709", "l": "LGI4 binds ADAM22,23,11 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102197", "l": "vinylacetate caboxylester hydrolase activity"}, {"i": "MetaCyc:RXN-12087"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30277", "l": "A + 2 H2O => AH2 + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48708", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol = a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9626817", "l": "PKC phosphorylates NCF1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61867", "l": "AH2 + dehydroprobetaenone I <=> A + probetaenone I"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047094", "l": "3-hydroxyphenylacetate 6-hydroxylase activity"}, {"i": "RHEA:22204", "l": "3-hydroxyphenylacetate + H(+) + NADPH + O2 = H2O + homogentisate + NADP(+)"}, {"i": "RHEA:22208", "l": "3-hydroxyphenylacetate + H(+) + NADH + O2 = H2O + homogentisate + NAD(+)"}, {"i": "MetaCyc:1.14.13.63-RXN"}, {"i": "EC:1.14.13.63", "l": "\"3-hydroxyphenylacetate 6-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939335", "l": "RNF181 polyubiquinates BCL10 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46435", "l": "(25R)-4beta,26-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta,4beta-dihydroxycholest-5-en-26-al + 2 H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803234", "l": "Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40423", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028260", "l": "δ12-PGJ3 spontaneously dehydrates to  15d-PGJ3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11728", "l": "cyclopentanol + NAD(+) = cyclopentanone + H(+) + NADH"}, {"i": "EC:1.1.1.163", "l": "\"Cyclopentanol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983421", "l": "Journey of cargo through Golgi complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33214", "l": "1,4-dihydroxy-2-naphthoate + all-trans-heptaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-7 + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852010", "l": "BTNL2 binds activated T cells surface (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66525", "l": "L-ascorbate(in) + monodehydro-L-ascorbate radical(out) => L-ascorbate(out) + monodehydro-L-ascorbate radical(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033952", "l": "iota-carrageenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693250", "l": "RHOD binds effectors at the Golgi membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839110", "l": "p-BCR-p-FGFR1 phosphorylates GAB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216043", "l": "Collagen type II binds integrin alpha10beta1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177937", "l": "Phosphorylation of EGFR by SRC kinase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15276", "l": "2-oxoglutarate + L-dopa <=> 3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43060", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate = beta-D-glucose 1-phosphate + glycerol"}, {"i": "EC:2.4.1.332", "l": "\"1,2-alpha-glucosylglycerol phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015614", "l": "ABC-type D-xylose transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64644", "l": "butan-1-ol + propanoyl-CoA = butyl propanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38798", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51282", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => (13R)-hydroperoxy-(9Z,11E)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629499", "l": "NEIL3 cleaves thymine glycol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32657", "l": "a coniferyl ester + NADPH => a carboxylate + eugenol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427528", "l": "Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444047", "l": "Receptor FFAR3 binds carboxylates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419049", "l": "ROCK activation by RHO (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034542", "l": "trimethylarsine oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2514865", "l": "cGMP dissociates from CNG channels (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.12"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22442", "l": "H(+) + UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine + UMP => UDP-alpha-D-galactose + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61558", "l": "gibberellin A15 + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => gibberellin A12 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22493", "l": "H2O + N-formimidoyl-L-glutamate => formamide + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031176", "l": "endo-1,4-beta-xylanase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31190", "l": "(3S)-hydroxydecanoyl-CoA + NAD(+) <=> 3-oxodecanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010491", "l": "UTP:arabinose-1-phosphate uridylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5683774", "l": "p-T68-CHEK2 dimerizes (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25747", "l": "L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190877", "l": "Insertion of connexons into the plasma membrane resulting in the formation of hemi-channels (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139919", "l": "Translocation of BIM to mitochondria (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37011", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1-acyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13605", "l": "2 L-ascorbate + O2 = 2 H2O + 2 L-dehydroascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2509831", "l": "ITPA hydrolyses XTP to XMP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38932", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28678", "l": "alpha-D-galactose <=> beta-D-galactose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045238", "l": "CXCR2 chemokine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64123", "l": "an N-(fatty acyl)-L-serine + H2O <=> a fatty acid + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1008200", "l": "NFE2 binds the beta globin locus control region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21830", "l": "2 H(+) + nitrate + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + nitrite + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375133", "l": "Basigin binds Mannose-carrying cell recognition molecules (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9691174", "l": "RAC1 binds effectors at the ER membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097269", "l": "all-trans-decaprenyl-diphosphate synthase activity"}, {"i": "RHEA:27802", "l": "(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = all-trans-decaprenyl diphosphate + 7 diphosphate"}, {"i": "EC:2.5.1.91", "l": "\"All-trans-decaprenyl-diphosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.49", "l": "\"Omptin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45368", "l": "H2O + N-(9Z-octadecenoyl)-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + (9Z)-octadecenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64940", "l": "dGDP + H2O = dGMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31821", "l": "5-epi-alpha-selinene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046563", "l": "methanol oxidase activity"}, {"i": "MetaCyc:METHANOL-OXIDASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16676", "l": "3-phosphonopyruvate + H2O <=> H(+) + phosphate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15986", "l": "formate + NAD(+) => CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008412", "l": "CDK4 phosphorylates RUNX2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42507", "l": "2-oxoglutarate + N(6)-acetyl-L-lysine <=> 6-acetamido-2-oxohexanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034545", "l": "fumarylpyruvate hydrolase activity"}, {"i": "RHEA:26168", "l": "3-fumarylpyruvate + H2O = fumarate + H(+) + pyruvate"}, {"i": "EC:3.7.1.20", "l": "\"3-fumarylpyruvate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37720", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-376884", "l": "glucose 6-phosphate [cytosol] => glucose 6-phosphate [endoplasmic reticulum lumen] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13249", "l": "(R)-2-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH"}, {"i": "EC:1.1.1.268", "l": "\"2-(R)-hydroxypropyl-CoM dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65346", "l": "(2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + valproyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58063", "l": "2-sulfinoacetaldehyde + H2O <=> acetaldehyde + H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019976", "l": "interleukin-2 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29370", "l": "CMP + H2O <=> cytidine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54422", "l": "5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+) => 3',3'-c-di-AMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15898", "l": "4-acetamidobutanoate + H2O => 4-aminobutanoate + acetate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102356", "l": "isoitalicene synthase activity"}, {"i": "MetaCyc:RXN-13373"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-622420", "l": "NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18005", "l": "D-threitol + NADP(+) = D-erythrulose + H(+) + NADPH"}, {"i": "EC:1.1.1.162", "l": "\"Erythrulose reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1861788", "l": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047776", "l": "citramalate lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59860", "l": "3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->6)-N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187382", "l": "Degradation of ubiquitinated SMAD3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36342", "l": "[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> 2-thio-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198599", "l": "AKT phosphorylates MDM2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28976", "l": "H(+)(out) + L-asparagine(in) => H(+)(in) + L-asparagine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39169", "l": "3-oxohexadecanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166284", "l": "Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66375", "l": "H2O + sn-glycerol 3-phosphate <=> glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17036", "l": "(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) <=> biphenyl-2,3-diol + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102715", "l": "gibberellin A17,oxoglutarate:oxygen oxidoreductase activity"}, {"i": "MetaCyc:RXN-6546"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696822", "l": "AKR1B15 reduces EST17b to E1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-844438", "l": "NLRP1 oligomerizes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54202", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.100", "l": "\"2,1-fructan:2,1-fructan 1-fructosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030942", "l": "endoplasmic reticulum signal peptide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41947", "l": "[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP <=> [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.3.-", "l": "\"With oxygen as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14143", "l": "adenosine 5'-phosphosulfate + 2 glutathione => AMP + glutathione disulfide + 2 H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40157", "l": "22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54803", "l": "[nsP1 protein]-N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidine + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) <=> [nsP1 protein]-L-histidine + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38635", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362549", "l": "Hh-Np traffics to the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52522", "l": "20-hydroxy prostaglandin E1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin E1 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112727", "l": "Serine phosphorylation of STATs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8853496", "l": "SCF:FBXL7 binds AURKA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53368", "l": "5,6-dihydrouridine(17) in tRNA + NADP(+) = H(+) + NADPH + uridine(17) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31988", "l": "(S)-2,3-epoxysqualene => baruol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047310", "l": "glutamine-scyllo-inositol transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23157", "l": "(E)-(indol-3-yl)acetaldehyde oxime => (indol-3-yl)acetonitrile + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19802", "l": "ATP + D-pantetheine 4'-phosphate + H(+) => 3'-dephospho-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375302", "l": "Kinetochore capture of astral microtubules (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9640167", "l": "RRAGA,B exchanges GDP for GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21470", "l": "5-O-beta-D-mycaminosyltylactone + dTDP + H(+) => dTDP-alpha-D-mycaminose + tylactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53503", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11966", "l": "5alpha-cholestane-3beta,5,6beta-triol => 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376419", "l": "Formation of NR-MED1 Coactivator Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60073", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2 => 4beta-hydroxymethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12046", "l": "a diacylglycerol + a fatty acid + H(+) => a triacylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665727", "l": "FMNL2 binds CDC42:GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14807", "l": "ADP + D-allose 6-phosphate + H(+) => ATP + D-allose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11655", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose <=> alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59760", "l": "apigenin + UDP-alpha-D-glucose = apigenin 7-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56455", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole <=> 12-epi-hapalindole U"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58890", "l": "4-nitrobenzoate + A + 2 H2O => 4-aminobenzoate + AH2 + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58618", "l": "glyoxylate + octanamide => N-octanoyl-(2S)-hydroxyglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21785", "l": "H2O + L-ascorbate + O2 => 2 H(+) + L-threonate + oxalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26451", "l": "CoA + NADP(+) + succinate semialdehyde => H(+) + NADPH + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938356", "l": "RMB14 binds RUNX2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23370", "l": "benzaldehyde + CO2 => H(+) + phenylglyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000036", "l": "acyl carrier activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44520", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58777", "l": "NADP(+) + pyridine 3-methanol => H(+) + NADPH + pyridine-3-carbaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.12.10"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102469", "l": "naringenin 2-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49010", "l": "aurachin C epoxide + H2O + NADP(+) => aurachin C + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12347", "l": "(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) <=> H(+) + L-glutamyl-tRNA(Glu) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57091", "l": "an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O <=> 3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35854", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099619", "l": "UDP-4-amino-4-deoxy-L-arabinose formyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097677", "l": "STAT family protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61502", "l": "delphinidin 3-O-beta-D-glucoside + UDP => delphinidin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43954", "l": "H2O + NADP(+) + omega-hydroxy-3,7,11,15-tetramethyl-hexadecanoate => 3,7,11,15-tetramethylhexadecanoate + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204392", "l": "Basigin binds MCT1, MCT3 and MCT4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65078", "l": "asperaculane D + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => dauca-4,7-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-452122", "l": "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429497", "l": "SLP-76 stimulates PLC gamma 2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451033", "l": "(S)-Malate <=> Fumarate + H2O (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018717", "l": "9-phenanthrol glycosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32269", "l": "glycine + succinate semialdehyde => 4-aminobutanoate + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36234", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58144", "l": "acetate + ATP + cytidine(34) in elongator tRNA(Met) = AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49747", "l": "deoxyviolaceinate + H(+) + O2 <=> CO2 + deoxyviolacein + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390673", "l": "CHRM2,4 bind acetylcholine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937792", "l": "RUNX3 binds SRC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66486", "l": "16alpha-hydroxygypsogenate 28-beta-D-glucoside + UDP => 16alpha-hydroxygypsogenate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27546", "l": "anthranilate + FADH2 + O2 = 3-hydroxyanthranilate + FAD + H(+) + H2O"}, {"i": "EC:1.14.14.8", "l": "\"Anthranilate 3-monooxygenase (FAD)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66980", "l": "2-methylbutanoyl-CoA + H2O = 2-methylbutanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19316", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33857", "l": "a mannosylinositol-1-phosphophytoceramide + GDP + H(+) => an inositol-1-phosphophytoceramide + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52219", "l": "[(1''->2')-ADP-alpha-D-ribose]n + H2O <=> [(1''->2')-ADP-alpha-D-ribose]n-1 + ADP-D-ribose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693536", "l": "ATM phosphorylates MDC1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51109", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21172", "l": "L-idonate + NAD(+) = 5-dehydro-D-gluconate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-481007", "l": "Exocytosis of platelet alpha granule contents (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086132", "l": "Dentin phosphoprotein binds integrin alphaVbeta1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17607", "l": "ADP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H(+) + phosphate => ATP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12274", "l": "CO2 + dopamine => H(+) + L-dopa"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22549", "l": "H2O + L-lysine + O2 => (S)-2-amino-6-oxohexanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14670", "l": "D-glyceraldehyde 3-phosphate + H2O + NADP(+) => (2R)-3-phosphoglycerate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47693", "l": "AH2 + neomycin C + S-adenosyl-L-methionine => 5'-deoxyadenosine + A + H(+) + L-methionine + neomycin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-83677", "l": "C4 deamination of cytidine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034046", "l": "poly(G) binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64819", "l": "5-aminolevulinate(in) <=> 5-aminolevulinate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66519", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62267", "l": "hydrogencarbonate(out) + selenite(out) + Zn(2+)(out) <=> hydrogencarbonate(in) + selenite(in) + Zn(2+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.135", "l": "\"Neopullulanase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047902", "l": "formylaspartate deformylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909721", "l": "Translocation of ISGF3 complex to nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15808", "l": "(7R,8S)-7,8-diammoniononanoate + ATP + CO2 <=> (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63678", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADH => CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42018", "l": "17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + H(+) + NADH => cortisone + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20597", "l": "2 L-cysteine + NAD(+) = H(+) + L-cystine + NADH"}, {"i": "EC:1.8.1.6", "l": "\"Cystine reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63151", "l": "H2O + N-(9Z-octadecenoyl)-taurine <=> (9Z)-octadecenoate + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1251992", "l": "Cleavage of P-ERBB4jmA isoforms by ADAM17 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874849", "l": "CREBRF binds CREB3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001532", "l": "interleukin-21 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46659", "l": "androst-4-ene-3,17-dione + H(+) + NADPH <=> 5beta-androstane-3,17-dione + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41140", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165162", "l": "Phosphorylation of TSC2 by PKB (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28635", "l": "(2E,6E)-farnesyl diphosphate = (+)-5-epi-aristolochene + diphosphate"}, {"i": "EC:4.2.3.61", "l": "\"5-epiaristolochene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5632649", "l": "Hh-Npp binds GAS1 and PTCH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62660", "l": "2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol = (2'R)-atrovenetin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.-", "l": "\"Phosphoric monoester hydrolases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13859", "l": "D-glucose + dolichyl phosphate + H(+) => dolichyl beta-D-glucosyl phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11396", "l": "5-methyldeoxycytidine 5'-phosphate + ATP = 5-methyldeoxycytidine diphosphate + ADP"}, {"i": "EC:2.7.4.19", "l": "\"5-methyldeoxycytidine-5'-phosphate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008257", "l": "protein histidine tele-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49517", "l": "2-oxoglutarate + N(1)-methyladenosine in mRNA + O2 => adenosine in mRNA + CO2 + formaldehyde + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110240", "l": "MPG glycosylase mediated recognition and binding of hypoxanthine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27409", "l": "3 a menaquinone + protoporphyrinogen IX = 3 a menaquinol + protoporphyrin IX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001039", "l": "RNA polymerase III hybrid type promoter sequence-specific DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12820", "l": "2,3-dihydrobiochanin A + NADP(+) <=> biochanin A + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164834", "l": "Enzyme-bound ATP is released (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1222491", "l": "Lactoferrin scavenges iron ions (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49240", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) = L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in)"}, {"i": "EC:2.7.1.193", "l": "\"Protein-N(pi)-phosphohistidine--N-acetyl-D-glucosamine phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38471", "l": "L-histidine + 3 S-adenosyl-L-methionine = 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.44", "l": "\"L-histidine N(alpha)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33859", "l": "(2S-3S)-versiconal hemiacetal = H2O + versicolorin B"}, {"i": "EC:4.2.1.143", "l": "\"Versicolorin B synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018804", "l": "RAC3 GEFs activate RAC3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977301", "l": "Histidine is decarboxylated to histamine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10659", "l": "guanidinoacetate + S-adenosyl-L-methionine <=> creatine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18932", "l": "AH2 + O2 + thiophene-2-carbonyl-CoA <=> 5-hydroxythiophene-2-carbonyl-CoA + A + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032841", "l": "calcitonin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5658430", "l": "NF1 is degraded by the proteasome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40665", "l": "2-aminoprop-2-enoate + H2O => L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198669", "l": "p38MAPK phosphorylates MSK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64199", "l": "an N-(fatty acyl)-L-lysine + H2O <=> a fatty acid + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69173", "l": "Joining of adjacent Okazaki fragments (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14469", "l": "2-aminomuconate 6-semialdehyde + H2O + NAD(+) = (2Z,4E)-2-aminomuconate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.32", "l": "\"Aminomuconate-semialdehyde dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445700", "l": "Myosin Binds ATP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42396", "l": "cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.205", "l": "\"tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43316", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033201", "l": "alpha-1,4-glucan synthase activity"}, {"i": "RHEA:18189", "l": "[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+)"}, {"i": "EC:2.4.1.21", "l": "\"Starch synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8987214", "l": "p-STAT3 dimerizes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37221", "l": "3-methyl-2-oxobutanoate + AH2 + NH4(+) => A + D-valine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953398", "l": "PIR oxygenates quercetin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592240", "l": "Formation of NRF2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046979", "l": "TAP2 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37469", "l": "1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP => 1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32962", "l": "H2O + L-isoleucine + NAD(+) <=> (S)-3-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15968", "l": "1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40106", "l": "H2O + propanoyl-CoA <=> CoA + H(+) + propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21880", "l": "2 H(+) + O2 + oxalate = 2 CO2 + H2O2"}, {"i": "EC:1.2.3.4", "l": "\"Oxalate oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43245", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51372", "l": "(9Z)-hexadecenoyl-CoA + glycine = CoA + H(+) + N-(9Z-hexadecenoyl)-glycine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050457", "l": "decylcitrate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56138", "l": "2 a phenolic radical donor + 2 H2O => 2 a phenolic donor + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52349", "l": "(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate => (24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28842", "l": "H(+)(out) + Zn(2+)(in) <=> H(+)(in) + Zn(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730899", "l": "Oligomerization of BCL10 and MALT1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202724", "l": "P-selectin binds P-selectin ligand (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2534378", "l": "Hv1 Mediated H+ Permeability (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805638", "l": "KAT6A acetylates TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15201", "l": "6-hydroxymellein + S-adenosyl-L-methionine = 6-methoxymellein + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.108", "l": "\"6-hydroxymellein O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5610735", "l": "NUMB binds ITCH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36712", "l": "ATP + H(+) + H2O + O-ureido-D-serine => ADP + CO2 + D-cycloserine + NH4(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54172", "l": "H2O + N(6)-acyl-L-lysyl-[protein] + NAD(+) = L-lysyl-[protein] + nicotinamide + O-acyl-ADP-D-ribose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45307", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193700", "l": "p75NTR ICD signals to NF-kB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21669", "l": "ATP + H2O + sn-glycerol 3-phosphate(out) => ADP + H(+) + phosphate + sn-glycerol 3-phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47893", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031824", "l": "type 1E serotonin receptor binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047102", "l": "aminomuconate-semialdehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43988", "l": "(2E,6E)-farnesyl diphosphate + H(+) + NADPH + O2 = (2E,6E)-omega-hydroxy-farnesyl diphosphate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787737", "l": "CSF3R binds CSF3 dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39622", "l": "(2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H(+) + NADPH <=> (14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22327", "l": "H2O + leukotriene A4 <=> leukotriene B4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16639", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP => [(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36756", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose => beta-D-Glc-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0019187", "l": "beta-1,4-mannosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56051", "l": "daidzein + UDP-alpha-D-glucose <=> daidzein 7-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17788", "l": "H(+) + L-glutamate <=> 4-aminobutanoate + CO2"}]}
{"type": "biolink:MolecularActivity", "ic": "62.496128459846446", "identifiers": [{"i": "GO:0016879", "l": "ligase activity, forming carbon-nitrogen bonds"}, {"i": "EC:6.3.-.-", "l": "\"Forming carbon-nitrogen bonds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51818", "l": "AMP(in) + diphosphate(in) + dodecanoyl-CoA(in) + H(+)(in) => ATP(in) + CoA(in) + dodecanoate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190519", "l": "Internalization of gap junction plaques (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23710", "l": "[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+) => [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246506", "l": "botC HC:LC binds GT1b on the target cell surface (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16295", "l": "(2S)-2-isopropylmalate => 2-isopropylmaleate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.23", "l": "\"Mucorpepsin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250930", "l": "B-WICH recruits histone acetyltransferases (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112429", "l": "Formation of FACT complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29991", "l": "H(+)(in) + L-lyxose(in) = H(+)(out) + L-lyxose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38588", "l": "UDP-alpha-D-glucose + vancomycin aglycone => devancoaminyl-vancomycin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37468", "l": "1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+) => 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864989", "l": "TFAP2A homodimer binds the TGFA gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111970", "l": "PKC phosphorylates GRK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30525", "l": "GDP + H(+) + oxidized coenzyme F420-2 + phosphate => GTP + L-glutamate + oxidized coenzyme F420-1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43712", "l": "ATP + dodecanoate + H(+) = diphosphate + dodecanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-936563", "l": "ISGylation of DDX58 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58914", "l": "ADP + H(+) + iron(III) dicitrate(in) + phosphate => ATP + H2O + iron(III) dicitrate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.224", "l": "\"Violacein synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4332356", "l": "CAMK2 binds MAP3K7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32619", "l": "L-threo-7,8-dihydrobiopterin + NADP(+) = H(+) + NADPH + sepiapterin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61438", "l": "AMP + H(+) + phosphate => ADP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56908", "l": "(7S)-O-acetylsalutaridinol = acetate + H(+) + thebaine"}, {"i": "EC:4.2.99.24", "l": "\"Thebaine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109702", "l": "PDPK1 phosphorylates AKT2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61268", "l": "H2O + L-2-aminohexanoate + O2 = 2-oxohexanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45680", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphate(in) = N-(hexadecanoyl)-sphing-4-enine-1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419490", "l": "Binding of ATP to P2X receptors (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12294", "l": "AMP + diphosphate + H(+) + L-seryl-tRNA(Ser) => ATP + L-serine + tRNA(Ser)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445714", "l": "Aquaporin-3 passively transports water out of cell (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1297354", "l": "Acrosin Cleavage (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004602", "l": "glutathione peroxidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0016731", "l": "oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor"}, {"i": "EC:1.18.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853792", "l": "RET tyrosine phosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47884", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004698", "l": "calcium-dependent protein kinase C activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429157", "l": "ABCC4 accumulation of dense granule contents (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669900", "l": "KIT mutants bind type II TKIs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466367", "l": "NRF1, PPRC1:HCFC1:NRF2 bind the TFB2M promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59547", "l": "N,N'-diacetylchitobiose + O2 <=> H2O2 + N,N'-diacetylchitobiono-1,5-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38435", "l": "(9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5138459", "l": "WNT5A:FZD4 is endocytosed (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.6", "l": "\"Carboxypeptidase D\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20270", "l": "4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate => 2 5-dehydro-4-deoxy-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033713", "l": "choline:oxygen 1-oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35197", "l": "L-quinate(out) => L-quinate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22073", "l": "ATP + L-ribulose => ADP + H(+) + L-ribulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64668", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57784", "l": "1,4-dinitrobenzene + NADH + O2 = 4-nitrocatechol + H(+) + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47903", "l": "ganglioside GM3 (d18:1(4E)) + H2O <=> a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645481", "l": "TIFA oligomerization (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0004772", "l": "sterol O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102409", "l": "sn-2-glycerol-3-phosphate C16:0-CoA acyl transferase activity"}, {"i": "MetaCyc:RXN-13736"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56891", "l": "UDP-4-dehydro-6-deoxy-alpha-D-glucose <=> UDP-4-dehydro-beta-L-rhamnose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391942", "l": "IP receptor can bind prostacyclin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928591", "l": "EPH:EFN tetramers oligomerise (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015519", "l": "D-xylose:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63454", "l": "GMP + H(+) + oxidized 3PG-factor420-0 => 3-[(R)-glyceryl]-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56031", "l": "3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) <=> 3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48780", "l": "ATP + L-erythrulose = ADP + H(+) + L-erythrulose 1-phosphate"}, {"i": "EC:2.7.1.209", "l": "\"L-erythrulose 1-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17825", "l": "ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+)"}, {"i": "EC:2.7.1.1", "l": "\"Hexokinase\""}, {"i": "EC:2.7.1.2", "l": "\"Glucokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110011", "l": "Binding of Grb10 to the insulin receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042890", "l": "3-phenylpropionic acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62052", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphate + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43731", "l": "methyl (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + juvenile hormone III + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49570", "l": "(3R)-3,4-epoxy-3-methylbut-1-ene + glutathione => 2-glutathionyl-2-methylbut-3-en-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53645", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-corvol ether B + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9653514", "l": "USP17L2 deubiquitinates RCE1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928639", "l": "p-EFNB binds GRB4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014449", "l": "RHOG binds effectors at the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64354", "l": "2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA => 3 H(+) + hexanoyl-CoA + 3 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450422", "l": "KSRP recruits RNA degradation activities (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050219", "l": "prostaglandin-A1 delta-isomerase activity"}, {"i": "RHEA:10460", "l": "prostaglandin A1 = prostaglandin C1"}, {"i": "EC:5.3.3.9", "l": "\"Prostaglandin-A(1) Delta-isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53327", "l": "2-glyceryl-prostaglandin H2 <=> 2-glyceryl-prostaglandin E2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54602", "l": "2-hydroxyoctanoyl-CoA + CO2 + succinate => 2-oxoglutarate + O2 + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27386", "l": "H2O + maleamate => maleate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482770", "l": "Release of platelet secretory granule components (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109860", "l": "MAP2K1 phosphorylates MAPK3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15552", "l": "S-methyl-5-thio-D-ribulose 1-phosphate <=> 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003914", "l": "DNA (6-4) photolyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37995", "l": "all-trans-nonaprenyl diphosphate + H(+) + homogentisate = 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate"}, {"i": "EC:2.5.1.117", "l": "\"Homogentisate solanesyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047537", "l": "2-aminohexanoate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666383", "l": "F8 variant is not cleaved by thrombin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030699", "l": "glycine reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15158", "l": "4-hydroxyphenylacetate + H(+) + NADPH + O2 => H2O + homogentisate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56345", "l": "a 7-hydroxyisoflavone + UDP-alpha-D-glucose => a 7-hydroxyisoflavone 7-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047005", "l": "16-alpha-hydroxysteroid dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19251", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + glycine => glyoxylate + L-kynurenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450054", "l": "Interleukin-2 receptor alpha binds interleukin-2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156678", "l": "Activation of Cdc25C (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23938", "l": "5-dehydro-D-gluconate + H(+) + NADPH => D-gluconate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391939", "l": "TP receptor can bind thromboxane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689111", "l": "PARK2 autoubiquitinates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18616", "l": "4-methoxybenzoate + AH2 + O2 <=> 4-hydroxybenzoate + A + formaldehyde + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190261", "l": "FGFR3c binds to FGF (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65385", "l": "a 5'-(N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O => (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59683", "l": "D-maltopentaose + O2 <=> D-maltopentaono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23895", "l": "3-nitropropanoate + NADP(+) <=> 3-nitroacrylate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9626816", "l": "PIN1 binds p-S345-NCF1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42952", "l": "cytidine(49) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(49) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39936", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071160", "l": "cyanophycin synthetase activity (L-aspartate-adding)"}, {"i": "RHEA:13277", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate = [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate"}, {"i": "EC:6.3.2.29", "l": "\"Cyanophycin synthase (L-aspartate-adding)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12661", "l": "(R)-carnitine + hexadecanoyl-CoA = CoA + O-hexadecanoyl-(R)-carnitine"}, {"i": "EC:2.3.1.21", "l": "\"Carnitine O-palmitoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373748", "l": "SEMA4D interacts with CD72 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8957241", "l": "TP73 tetramer translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22051", "l": "7,8-dihydroneopterin 3'-triphosphate <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419389", "l": "LPA-binding receptors bind LPA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869438", "l": "Dissociation of clathrin-associated proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34658", "l": "C30 botryococcene + 2 S-adenosyl-L-methionine <=> 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 H(+) + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40979", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357828", "l": "RIPK1 is cleaved by CASP8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014141", "l": "HEY2 gene expression is positively regulated by NOTCH3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-873917", "l": "Translocation of STAT1 dimer to nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59762", "l": "apigenin 7-O-beta-D-glucoside + H(+) + UDP => apigenin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296304", "l": "GPR31 is a receptor for 12(S)-HETE (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21772", "l": "cytidine(6666) in apoB mRNA + H(+) + H2O = NH4(+) + uridine(6666) in apoB mRNA"}, {"i": "EC:3.5.4.36", "l": "\"mRNA(cytosine(6666)) deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36808", "l": "H(+) + malonyl-CoA + octacosanoyl-CoA => 3-oxo-triacontanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44072", "l": "1-O-alkyl-2-acyl-sn-glycerol + ATP = 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218811", "l": "DOCK180:ELMO binds CRK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10945", "l": "H2O + psi-UMP => phosphate + pseudouridine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16526", "l": "2-dehydro-3-deoxy-D-galactonate + ATP => 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65672", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontenoyl)-sphing-4-enine = a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17027", "l": "H(+) + L-xylulose + NADPH => NADP(+) + xylitol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11810", "l": "bergapten + S-adenosyl-L-homocysteine => bergaptol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53329", "l": "H2O + UDP-2,3-diacyl-alpha-D-glucosamine => 2,3-diacyl-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015083", "l": "aluminum ion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.37", "l": "\"Saccharolysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66729", "l": "ATP + H2O + N-acetyl-L-aspartyl-L-glutamate(in) => ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66658", "l": "Cu(+)(out) + H(+) + monodehydro-L-ascorbate radical(in) => Cu(2+)(out) + L-ascorbate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635850", "l": "GLI1 binds HHIP gene, PTCH2 gene and BOC gene promoters (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48179", "l": "decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651828", "l": "PARG dePARylates PARP1,PARP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964884", "l": "Dephosphorylation of EPSP yields chorismate (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549129", "l": "OCT1 transports organic cations into hepatic cells (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51955", "l": "(E)-2-methylpropanal oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2-methylpropanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202144", "l": "Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809764", "l": "SBF1 binds MTMR2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31074", "l": "(S)-methylmalonate semialdehyde + L-alanine <=> (S)-3-amino-2-methylpropanoate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65491", "l": "3 ATP <=> 2',3',3'-c-tri-AMP + 3 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199154", "l": "CD200 binds to CD200R (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40032", "l": "ent-copalyl diphosphate + H2O => diphosphate + ent-manool"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209828", "l": "Tryptophan is hydroxylated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9630923", "l": "NFkB inhibitor binds NFkB complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55777", "l": "all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate => 4-hydroxy-4-O-(beta-D-glucuronide)-all-trans-retinoate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.72"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937989", "l": "RUNX1 binds PRC1 complexes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "64.445068439609713", "identifiers": [{"i": "GO:0015294", "l": "solute:cation symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43329", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37690", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507873", "l": "Aquaporins passively transport urea out of cells (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1297354", "l": "Acrosin Cleavage (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17806", "l": "H2O + S-adenosyl-L-homocysteine => adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983285", "l": "RAD51B binds RAD51C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17476", "l": "GTP + H2O <=> 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22490", "l": "formaldehyde + glutathione => S-(hydroxymethyl)glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013004", "l": "RHOA binds effectors at the ER membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5096488", "l": "RRP8 binds RNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392202", "l": "Dissociation of the P2Y purinoceptor 12:Gi complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53913", "l": "butanoyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-butanoyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45042", "l": "2 [Fe(II)cytochrome c] + 2 H(+) + nitroxyl => 2 [Fe(III)cytochrome c] + hydroxylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18362", "l": "dolichyl D-xylosyl phosphate + L-seryl-[protein] => 3-O-(beta-D-xylosyl)-L-seryl-[protein] + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168875", "l": "Trimerization of HA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66139", "l": "acetyl-CoA + tyramine <=> CoA + H(+) + N-acetyltyramine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186819", "l": "SH2 domain of Src binds to the active receptor (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15274", "l": "2-oxoglutarate + L-dopa => 3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445077", "l": "Transport of L1 from C-domain to P-domain (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26152", "l": "(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate"}, {"i": "EC:2.5.1.78", "l": "\"6,7-dimethyl-8-ribityllumazine synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005009", "l": "insulin-activated receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57042", "l": "D-apiofuranose => aldehydo-D-apiose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22259", "l": "a (3R)-3-hydroxyacyl-CoA + NADP(+) <=> a 3-oxoacyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0034323", "l": "O-butanoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3782655", "l": "HDAC10 deacetylates histone (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163750", "l": "Dephosphorylation of phosphoPFKFB1 by PP2A complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008015", "l": "RUNX2 binds STAT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43955", "l": "3,7,11,15-tetramethylhexadecanoate + H(+) + NADPH + O2 <=> H2O + NADP(+) + omega-hydroxy-3,7,11,15-tetramethyl-hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002057", "l": "guanine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607725", "l": "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5671702", "l": "AP1G2 binds HGS and CHMP2A (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047299", "l": "tryptophan-phenylpyruvate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-429101", "l": "HMIT co-transports myo-inositol with a proton (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10840", "l": "H2O + O-phospho-L-homoserine = L-threonine + phosphate"}, {"i": "EC:4.2.3.1", "l": "\"Threonine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390593", "l": "ATP Hydrolysis By Myosin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66224", "l": "asc-C9-CoA + O2 = asc-DeltaC9-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34606", "l": "15-methylhexadecasphinganine + a fatty acyl-CoA <=> CoA + H(+) + N-acyl-15-methylhexadecasphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788061", "l": "Fibronectin degradation by ADAM8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686578", "l": "Activated ATM phosphorylates ABL1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31747", "l": "3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + H2O + NADP(+) = 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH"}, {"i": "EC:1.2.1.91", "l": "\"3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48208", "l": "H(+) + nonanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8858500", "l": "CLEC10A binds Tn-MUC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3159259", "l": "MMAA:MUT binds AdoCbl (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38885", "l": "a fatty acyl-CoA + AMP + diphosphate => a fatty acid + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44373", "l": "Cr(6+) + 2 NADH + O2 => Cr(3+) + 2 H(+) + 2 NAD(+) + superoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24061", "l": "N-hydroxy-L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45005", "l": "(R)-carnitine + 2,6-dimethylheptanoyl-CoA => CoA + O-2,6-dimethylheptanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657767", "l": "Expression of APOD regulated by NR1H2 or NR1H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39679", "l": "(11Z)-octadecenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29577", "l": "L-serine(out) + Na(+)(out) => L-serine(in) + Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18294", "l": "ATP + CoA + oxalate => AMP + diphosphate + oxalyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23677", "l": "ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77608", "l": "Binding of A1CF to stem-looped RNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34431", "l": "(+)-secoisolariciresinol + NADP(+) = (-)-lariciresinol + H(+) + NADPH"}, {"i": "EC:1.23.1.4", "l": "\"(-)-lariciresinol reductase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018774", "l": "2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity"}, {"i": "MetaCyc:3.7.1.8-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39190", "l": "(3R)-hydroxydocosanoyl-CoA <=> (2E)-docosenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41146", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60084", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+) = a 4alpha-methyl-3-oxosteroid + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58839", "l": "24-methylenecycloartanol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64211", "l": "an N-(fatty acyl)-L-glutamine + H2O <=> a fatty acid + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12556", "l": "6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)"}, {"i": "EC:3.1.1.31", "l": "\"6-phosphogluconolactonase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32867", "l": "myo-inositol(out) = myo-inositol(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28213", "l": "H2O + L-saccharopine + O2 <=> (S)-2-amino-6-oxohexanoate + H2O2 + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102049", "l": "indole-3-acetyl-methionine synthetase activity"}, {"i": "MetaCyc:RXN-10431"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-381091", "l": "IRE1 dimer autophosphorylates (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28252", "l": "acetoacetyl-CoA + CO2 + CoA => acetyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21419", "l": "NADP(+) + sn-glycerol 1-phosphate <=> dihydroxyacetone phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004417", "l": "hydroxyethylthiazole kinase activity"}, {"i": "RHEA:24212", "l": "5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)"}, {"i": "EC:2.7.1.50", "l": "\"Hydroxyethylthiazole kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22970", "l": "butanoyl-CoA + H(+) + NADH => butanal + CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341072", "l": "SUMOylation of RARA with SUMO2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51720", "l": "ATP(in) + CoA(in) + H(+)(out) + octadecanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + octadecanoyl-CoA(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46915", "l": "H2O + juvenile hormone III <=> H(+) + juvenile hormone III carboxylate + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789114", "l": "Hydroxyl radical reacts with the base and sugar moiety of DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29444", "l": "H(+)(in) + L-alanine(in) => H(+)(out) + L-alanine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29817", "l": "ADP + H(+) + L-proline(in) + phosphate => ATP + H2O + L-proline(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66507", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47646", "l": "4 H(+) + N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine => adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445071", "l": "Reinsertion of L1 into the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607734", "l": "PKC-delta translocates to plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41448", "l": "2-oxoglutarate + L-isoleucine + O2 = (4S)-4-hydroxy-L-isoleucine + CO2 + succinate"}, {"i": "EC:1.14.11.45", "l": "\"L-isoleucine 4-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50817", "l": "androst-4-ene-3,17-dione + H(+) + NADPH => 5alpha-androstan-3,17-dione + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16219", "l": "H(+) + L-arabinonate => H2O + L-arabinono-1,4-lactone"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015561", "l": "rhamnose:proton symporter activity"}, {"i": "TCDB:2.A.7.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-481044", "l": "Surface deployment of platelet alpha granule membrane components (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35384", "l": "precorrin-6B + S-adenosyl-L-methionine => CO2 + H(+) + precorrin-7 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-179410", "l": "Association of Nek2A with MCC:APC/C (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27934", "l": "(3S)-3-hydroxy-D-aspartate = glycine + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202702", "l": "CD177 binds PECAM-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59284", "l": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = D-glucose + N-octadecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12619", "l": "ADP + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate => ATP + N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39370", "l": "(2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H(+) + NADPH <=> (13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35602", "l": "NADP(+) + propane-1,3-diol <=> 3-hydroxypropanal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59535", "l": "(S)-reticuline + S-adenosyl-L-methionine <=> (S)-codamine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45821", "l": "mesaconate + succinyl-CoA => 2-methylfumaryl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40209", "l": "(3S)-hydroxytetradecanedioyl-CoA => (2E)-tetradecenedioyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047235", "l": "sucrose 6F-alpha-galactotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34875", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA + 2 H2O + NADP(+) = 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2197690", "l": "Detachment of WASP/WAVE (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694427", "l": "MIA3 binds procollagen VII (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114256", "l": "CYCS:APAF1 binds procaspase-9 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28629", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + solavetivone => O2 + reduced [NADPH--hemoprotein reductase] + solavetivol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61713", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + N(omega)-hydroxy-N(delta)-methyl-L-arginine => 2 [Fe(III)-cytochrome b5] + H2O + N(delta)-methyl-L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40280", "l": "(R)-carnitine + dodecanoyl-CoA => CoA + O-dodecanoyl-R-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156699", "l": "Inactivation of Wee1 kinase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1254251", "l": "ERBB4s80 binds YAP1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3245898", "l": "TCN1 binds Cbl in the circulation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11386", "l": "2-oxodecanoate + H(+) + NADH => (S)-2-hydroxydecanoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37765", "l": "1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112042", "l": "Opioid binds MOR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23371", "l": "H(+) + phenylglyoxylate <=> benzaldehyde + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18283", "l": "fumarate + H(+) + NADH => NAD(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31299", "l": "H2O + NAD(+) + perillyl aldehyde = 2 H(+) + NADH + perillate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40174", "l": "dodecanoyl-CoA + O2 <=> (2E)-dodecenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64983", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21562", "l": "1,4-dithiothreitol + 2,3-epoxyphylloquinone => 3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43106", "l": "A + 2 H2O + N-acyleicosasphing-4-enine => AH2 + N-acyleicosasphinganine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848776", "l": "PTK6 phosphorylates DOK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29528", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607746", "l": "PKC-delta is activated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49041", "l": "(-)-5'-demethylyatein + S-adenosyl-L-methionine => (-)-yatein + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029690", "l": "Caspase-6 translocates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10361", "l": "3,4-dihydrocoumarin + H2O => 3-(2-hydroxyphenyl)propanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382553", "l": "ABCA7:Apo1A-mediated phospholipid efflux (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16137", "l": "2'-deoxymugineate + NADP(+) = 3''-deamino-3''-oxonicotianamine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951500", "l": "Dissociation of CANX from nonameric complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41305", "l": "(4R)-hydroxysphinganine + dodecanoate => H2O + N-dodecanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22337", "l": "glycine betaine + L-homocysteine => L-methionine + N,N-dimethylglycine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015445", "l": "P-type silver transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0001883", "l": "purine nucleoside binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29820", "l": "ATP + H2O + L-isoleucine(out) => ADP + H(+) + L-isoleucine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340587", "l": "RNF43 frameshift mutants show enhanced WNT siganling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22386", "l": "1D-myo-inositol hexakisphosphate + H(+) + phosphate => 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62057", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11053", "l": "4-aminobenzoate + 2 H(+) + NADH + O2 => 4-aminophenol + CO2 + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004757", "l": "sepiapterin reductase activity"}, {"i": "EC:1.1.1.153", "l": "\"Sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12981", "l": "H2O + O2 + S-sulfanylglutathione = glutathione + 2 H(+) + sulfite"}, {"i": "EC:1.13.11.18", "l": "\"Persulfide dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60180", "l": "ATP + D-fructose(out) + H2O = ADP + D-fructose(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59629", "l": "H2O + N(2)-(4-aminobutanoyl)-L-arginine => 4-aminobutanoate + L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50209", "l": "cortisol + NAD(+) => cortisone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45206", "l": "[methyl-Co(III) methanol-specific corrinoid protein] + H2O => [Co(I) methanol-specific corrinoid protein] + H(+) + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110311", "l": "POLZ extends translesion synthesis (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38286", "l": "itaconate + succinyl-CoA <=> itaconyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56017", "l": "H2O + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186798", "l": "GAP binds to PDGF-beta receptors only (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23966", "l": "(E)-ferulate + 2 H(+) + NADPH => (E)-coniferaldehyde + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47403", "l": "3-oxo-(9Z-octadecenoyl)-CoA + CoA <=> (7Z)-hexadecenoyl-CoA + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016979", "l": "lipoate-protein ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18815", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate => (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981713", "l": "C4b binds to cell surface (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033451", "l": "GUA codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28399", "l": "H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate => L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18719", "l": "3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine => 3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38728", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5444516", "l": "Formation of MSH2:MSH6 Complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416683", "l": "SEMA3E binds to PLXND1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15280", "l": "acetyl-CoA + L-lysyl-[alpha-tubulin] <=> CoA + H(+) + N(6)-acetyl-L-lysyl-[alpha-tubulin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657637", "l": "ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 1-meA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202222", "l": "Phosphorylation of PKC theta (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374680", "l": "L1 trans-homophilic interaction (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50533", "l": "acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28549", "l": "D-glucose <=> D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236970", "l": "Proteasomal clevage of exogenous antigen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61102", "l": "(2S)-dihydrotricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654603", "l": "Activated FGFR2 binds FRS3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32794", "l": "L-ectoine(in) <=> L-ectoine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9706393", "l": "RHOBTB3 binds ATP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28677", "l": "beta-D-galactose => alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618107", "l": "ATP binding to HSP90 triggers conformation change (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2197697", "l": "Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36856", "l": "an N-acetyl-L-cysteine-S-conjugate + H2O => acetate + an S-substituted L-cysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "79.238648346243679", "identifiers": [{"i": "GO:0017069", "l": "snRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55718", "l": "(9Z)-octadecenoate + (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+) => (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(2'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950757", "l": "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21264", "l": "A + glycolate = AH2 + glyoxylate"}, {"i": "EC:1.1.99.14", "l": "\"Glycolate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033855", "l": "nicotianamine aminotransferase activity"}, {"i": "RHEA:22104", "l": "2-oxoglutarate + nicotianamine = 3''-deamino-3''-oxonicotianamine + L-glutamate"}, {"i": "EC:2.6.1.80", "l": "\"Nicotianamine aminotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55114", "l": "(3R)-hydroxy-4-methylpentanoyl-[ACP] + NADP(+) => 4-methyl-3-oxopentanoyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112434", "l": "Formation of DSIF complex  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687109", "l": "8b binds MAP1LC3B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684321", "l": "nsp3 cleaves nsp1-4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60258", "l": "AH2 + formaldehyde + L-lysyl(4)-[histone H3] => A + H2O + N(6)-methyl-L-lysyl(4)-[histone H3]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421836", "l": "trans-Golgi Network Derived Vesicle Uncoating (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43628", "l": "L-serine + NAD(+) = aminoacetaldehyde + CO2 + NADH"}, {"i": "EC:1.1.1.387", "l": "\"L-serine 3-dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201603", "l": "Caspase-mediated cleavage of PKC theta (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35740", "l": "cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin] => 4-methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183055", "l": "Binding of CBL to EGFR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43013", "l": "L-homocysteine => 2-aminobut-2-enoate + H(+) + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784204", "l": "JAKs bind OSMR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57518", "l": "15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dolabradiene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14762", "l": "H(+) + hexadecanoyl-CoA + L-serine => 3-oxosphinganine + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38038", "l": "(2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate <=> (4Z)-2-oxohept-4-enedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102741", "l": "paraxanthine:S-adenosyl-L-methionine 3-N-methyltransferase activity"}, {"i": "RHEA:10280", "l": "1,7-dimethylxanthine + S-adenosyl-L-methionine = caffeine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190519", "l": "Internalization of gap junction plaques (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-996755", "l": "ZFPM proteins bind GATA proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-171122", "l": "LDL + LDLR => LDL:LDLR complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24623", "l": "NAD(+) + octan-1-ol <=> H(+) + NADH + octanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39433", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990955", "l": "G-rich single-stranded DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5218906", "l": "RIPK3 phosphorylates MLKL (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374251", "l": "DARC  is a non-specific receptor for many chemokines (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3159253", "l": "MMAB transfers adenosyl group from ATP to cob(I)alamin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645481", "l": "TIFA oligomerization (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.38"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25632", "l": "myricetin + S-adenosyl-L-methionine <=> H(+) + laricitrin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62397", "l": "(1S,2S)-pseudoephedrine + NAD(+) => (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102037", "l": "4-nitrotoluene monooxygenase activity"}, {"i": "MetaCyc:R361-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693783", "l": "NAALADases hydrolyse NAAG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65539", "l": "1,3,7-trimethylurate + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + theacrine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626938", "l": "Beta-catenin binds SOX proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9619355", "l": "CaMKK autophosphorylates in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13878", "l": "a 2-oxocarboxylate + L-ornithine => an L-alpha-amino acid + L-glutamate 5-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980125", "l": "ITCH binds DTX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938338", "l": "NFE2 gene expression is stimulated by RUNX1:CBFB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64248", "l": "decanoyl-CoA + glycine = CoA + H(+) + N-decanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13888", "l": "H2O + stipitatonate <=> CO2 + stipitatate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109822", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47162", "l": "4-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADH => 4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222093", "l": "BRD7 binds TP53 and EP300 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51531", "l": "4-hydroxy-3-methoxybenzoate + H(+) <=> CO2 + guaiacol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62099", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 2-(9Z-octadecenoyl)-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.146", "l": "\"Beta-galactofuranosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31173", "l": "(2E)-tetradecenoyl-CoA + H2O => (3S)-hydroxytetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60411", "l": "Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O <=> Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine] + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58737", "l": "H2O + TTP => 5-methyl-UMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166363", "l": "TRAF6 binds to hp- IRAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45103", "l": "6-demethylmitomycin B + S-adenosyl-L-methionine <=> mitomycin B + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2545196", "l": "FN1 dimerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624952", "l": "Assembly of the retrograde IFT train (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40171", "l": "dodecanoyl-CoA + O2 = (2E)-dodecenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.1.2"}]}
{"type": "biolink:MolecularActivity", "ic": "57.730630876541539", "identifiers": [{"i": "GO:0016709", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"}, {"i": "REACT:R-HSA-2162187", "l": "DHB is hydroxylated to DHDB by COQ6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400434", "l": "FFAR1 binds fatty acids (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48098", "l": "2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine => L-arginyl-[protein] + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42286", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944219", "l": "Association of procollagen type XVI (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2429719", "l": "MCPH1 sequesters condensin II (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30288", "l": "15-cis-phytoene + 2 a plastoquinone => 9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43952", "l": "3,7,11,15-tetramethylhexadecanoate + H(+) + NADPH + O2 = H2O + NADP(+) + omega-hydroxy-3,7,11,15-tetramethyl-hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670413", "l": "JAK2 binds to p-KIT mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694409", "l": "Nucleotide exchange on RAB1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191636", "l": "Phosphorylation of Cx43 by c-src (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47736", "l": "cytidine(1404) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1404) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45409", "l": "(2E)-dodecenoyl-CoA + H(+) + NADH => dodecanoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14454", "l": "4-(phosphooxy)-L-threonine + NAD(+) => (2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0034326", "l": "butanoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-912790", "l": "CBL binds CRK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-167429", "l": "The receptor:G-protein complex  binds GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex. (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11471", "l": "(S)-3-methyl-2-oxopentanoate + L-valine <=> 3-methyl-2-oxobutanoate + L-isoleucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-481010", "l": "Surface deployment of platelet dense granule membrane components (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956427", "l": "RETSAT reduces atROL to at-13,14-dhROL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-984733", "l": "Kinesin-3 is a dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18759", "l": "CO2 + cylindrospermopsin + succinate => 2-oxoglutarate + 7-deoxycylindrospermopsin + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22308", "l": "O2 + xylitol = D-xylose + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46789", "l": "a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(6Z,9Z,12Z,15Z)-octadectetraenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61639", "l": "ATP + CoA + isophthalate <=> AMP + diphosphate + isophthalyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14986", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17053", "l": "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate"}, {"i": "EC:2.2.1.2", "l": "\"Transaldolase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018578", "l": "protocatechuate 3,4-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11920", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O"}, {"i": "EC:4.2.1.96", "l": "\"4a-hydroxytetrahydrobiopterin dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16174", "l": "(4-hydroxyphenyl)acetaldehyde + dopamine => (S)-norcoclaurine + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015156", "l": "melibiose transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42664", "l": "L-arabinofuranose + NADP(+) = H(+) + L-arabinono-1,4-lactone + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24815", "l": "3-methyl-2-oxobutanoate + L-glutamate => 2-oxoglutarate + L-valine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32765", "l": "(3R)-3-methyl-D-ornithyl-N(6)-L-lysine + H2O => (3R)-3-methyl-D-ornithine + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706344", "l": "FLT3 phosphorylates GRB10 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22784", "l": "(2R)-O-phospho-3-sulfolactate = H(+) + phosphoenolpyruvate + sulfite"}, {"i": "EC:4.4.1.19", "l": "\"Phosphosulfolactate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41151", "l": "1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-hydroperoxy-10E-octadecenoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27390", "l": "(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O => pyruvate + salicylaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37034", "l": "D-ribonate <=> 2-dehydro-3-deoxy-D-arabinonate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17302", "l": "ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] => ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58110", "l": "acetate + L-lysyl-[protein] => H2O + N(6)-acetyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015401", "l": "urea:sodium symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450975", "l": "isocitrate <=> citrate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50965", "l": "cytidine(8) in tRNA + H(+) + H2O => NH4(+) + uridine(8) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57989", "l": "(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose => (20S)-ginsenoside F2 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0018455", "l": "alcohol dehydrogenase [NAD(P)+] activity"}, {"i": "RHEA:10736", "l": "a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168947", "l": "Ligand binds to TLR10 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42630", "l": "5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(747) in 23S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20889", "l": "3-hydroxy-2-methylpropanoyl-CoA + H2O => 3-hydroxy-2-methylpropanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8871193", "l": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13131", "l": "4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP => cis-4-coumarate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48329", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose => GDP + H(+) + III(4)-a-Fuc-Lc4Cer(d18:1(4E))"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50842", "l": "(17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24998", "l": "H(+) + H2O + N,N-dihydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42092", "l": "all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177930", "l": "GAB1 phosphorylation by EGFR kinase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42687", "l": "H2O + L-gamma-glutamyl-hercynylcysteine S-oxide <=> L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65132", "l": "2-oxoglutarate + O2 + preaustinoid A1 = CO2 + H2O + preaustinoid A2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56803", "l": "apo-[corrinoid adenosyltransferase] + cob(II)yrinate a,c diamide <=> cob(II)yrinate a,c diamide--[corrinoid adenosyltransferase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708557", "l": "FBXL17 binds BACH1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61684", "l": "glycero-2-phosphocholine + H2O = glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59746", "l": "CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein] => (9Z)-octadecenoyl-CoA + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53688", "l": "2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15764", "l": "L-homoserine + NADP(+) <=> H(+) + L-aspartate 4-semialdehyde + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784765", "l": "p-Y705-STAT3 dimerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678998", "l": "Endosomal TLRs pass through the Golgi (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "81.20444558259193", "identifiers": [{"i": "GO:0000217", "l": "DNA secondary structure binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.95"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36236", "l": "1-O-alkyl-sn-glycero-3-phosphate + an acyl-CoA => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48357", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43722", "l": "juvenile hormone III + S-adenosyl-L-homocysteine => juvenile hormone III carboxylate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25873", "l": "H2O2 + pyridine => H2O + pyridine N-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54250", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213236", "l": "TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158340", "l": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112435", "l": "Formation of Elongin BC complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4755524", "l": "SUMOylation of NR1I2 with SUMO3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034574", "l": "didemethylisoproturon dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13788", "l": "citramalyl-CoA <=> H2O + itaconyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10995", "l": "glycolate + NADP(+) <=> glyoxylate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51676", "l": "[protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide = [protein]-dithiol + 2 AH2 + H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213201", "l": "Formation of collagen fibres (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44678", "l": "a diacylglycerol + an all-trans-retinyl ester => a triacyl-sn-glycerol + all-trans-retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15757", "l": "L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH"}, {"i": "RHEA:15761", "l": "L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH"}, {"i": "EC:1.1.1.3", "l": "\"Homoserine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59239", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + isoelisabethatriene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49037", "l": "(-)-pluviatolide + S-adenosyl-L-methionine => (-)-bursehernin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0008990", "l": "rRNA (guanine-N2-)-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8873946", "l": "OTUD3 deubiquitinates PTEN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20183", "l": "6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H(+) + UMP => alpha-D-mannose derivative + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31642", "l": "mycinamicin III + S-adenosyl-L-methionine <=> H(+) + mycinamicin IV + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71783", "l": "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696146", "l": "AOC2 deaminates TYR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51919", "l": "(2S)-2-amino-3-butenoate + H2O <=> 2-oxobutanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60373", "l": "D-fructose(out) => D-fructose(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849906", "l": "SALM1 binds NMDA receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34385", "l": "beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + H(+) + UDP => alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + UDP-alpha-D-galactofuranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21840", "l": "N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874079", "l": "PTK2 binds activated MET (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30212", "l": "2 [Fe(III)cytochrome c] + H2O + nitrous oxide => 2 [Fe(II)cytochrome c] + 2 H(+) + 2 nitric oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17554", "l": "ATP + guanidinoethyl methyl phosphate => ADP + H(+) + N'-phosphoguanidinoethyl methylphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44506", "l": "a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate => 4-hydroxybenzoate + an all-trans-polyprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043993", "l": "histone acetyltransferase activity (H3-K18 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43891", "l": "[sulfur carrier]-H + [sulfur-carrier protein]-S-sulfanyl-L-cysteine <=> [sulfur carrier]-SH + [sulfur-carrier protein]-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29815", "l": "ATP + H2O + L-proline(out) = ADP + H(+) + L-proline(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28125", "l": "ATP + di-trans,octa-cis-undecaprenol <=> ADP + di-trans,octa-cis-undecaprenyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5651773", "l": "LIG1 binds POLB at long-patch BER site (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53696", "l": "2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112395", "l": "Abortive termination of elongation after arrest (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25553", "l": "9alpha-copalyl diphosphate => diphosphate + stemar-13-ene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41831", "l": "(3R)-hydroxyhexanoyl-[ACP] <=> (2E)-hexenoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51909", "l": "dATP + H2O => dADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37282", "l": "ATP + H2O + L-alanyl-L-histidine(out) <=> ADP + H(+) + L-alanyl-L-histidine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.61"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237160", "l": "MTA is cleaved and phosphorylated (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39070", "l": "3-oxooctanedioyl-CoA + CoA <=> acetyl-CoA + hexanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71445", "l": "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849055", "l": "PTK6 binds ARHGAP35 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22569", "l": "ascopyrone M => ascopyrone P"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418904", "l": "A1 and A3 receptors bind adenosine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8873946", "l": "OTUD3 deubiquitinates PTEN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44403", "l": "3-demethylubiquinol-6 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52081", "l": "12-octadecanoyloxy-octadecanoate + H2O => 12-hydroxyoctadecanoate + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192841", "l": "Viral Protein Synthesis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4755524", "l": "SUMOylation of NR1I2 with SUMO3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18247", "l": "ADP + CoA + H(+) => 3'-dephospho-CoA + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54955", "l": "ATP + CoA + nonanoate <=> AMP + diphosphate + nonanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9633044", "l": "ESR binds STRN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42297", "l": "a 1-acyl-sn-glycero-3-phosphate + a fatty acyl-[ACP] => a 1,2-diacyl-sn-glycero-3-phosphate + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390674", "l": "ADRB1 bind ADR,NAd (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909718", "l": "Formation of p-STAT1 homodimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676589", "l": "RANKL,sRANKL trimer binds RANK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49083", "l": "dibenzothiophene 5-oxide + FMNH2 + O2 <=> dibenzothiophene 5,5-dioxide + FMN + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39704", "l": "(2E,13Z)-eicosadienoyl-CoA + H(+) + NADPH => (13Z)-eicosenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354273", "l": "AP-1 transcription factor forms a complex with STAT92E and DSP1 which displaces REL-68 from its target gene (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15092", "l": "(R)-lactate + A <=> AH2 + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354060", "l": "Translocation of RIAM to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034780", "l": "glyphosate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24799", "l": "(S)-2-amino-6-oxoheptanedioate => (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68960", "l": "DNA polymerase epsilon binds at the origin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102255", "l": "neo-lambda-carrahexaose hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41624", "l": "3-sulfinopropanoyl-CoA + H2O = H(+) + propanoyl-CoA + sulfite"}, {"i": "EC:3.13.1.4", "l": "\"3-sulfinopropanoyl-CoA desulfinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25340", "l": "isocyanate + NH4(+) => H(+) + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1614544", "l": "Sulfite is oxidized to sulfate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672948", "l": "MARK3 phosphorylates KSR1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41267", "l": "H2O + N-(15Z-tetracosenoyl)-sphing-4-enine = (15Z)-tetracosenoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70486", "l": "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13781", "l": "an L-alpha-amino acid + H2O + O2 = a 2-oxocarboxylate + H2O2 + NH4(+)"}, {"i": "EC:1.4.3.2", "l": "\"L-amino-acid oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977363", "l": "Factor H binds to C3bBb (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36066", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + kunzeaol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29176", "l": "2 O2 + ubiquinol-8 => 2 H(+) + 2 superoxide + ubiquinone-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-947514", "l": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14669", "l": "D-glyceraldehyde 3-phosphate + H2O + NADP(+) = (2R)-3-phosphoglycerate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805740", "l": "SETD8 methylates TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434362", "l": "Recruitment Of Cytoplasmic Proteins To Vesicles (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66336", "l": "L-glutamate(out) = L-glutamate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213246", "l": "Disassociation of CLIP from MHC II (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13240", "l": "D-fructose 6-phosphate + L-glutamine <=> D-glucosamine 6-phosphate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15843", "l": "6-phospho-D-glucono-1,5-lactone + H(+) + NADPH => D-glucose 6-phosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004505", "l": "phenylalanine 4-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604360", "l": "Initial activation of proMMP2 by MMP14 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13914", "l": "L-threonine => D-threonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59858", "l": "[methyl-Co(III) tetramethylammonium-specific corrinoid protein] + trimethylamine => [Co(I) tetramethylammonium-specific corrinoid protein] + H(+) + tetramethylammonium"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18446", "l": "H2O + IMP => 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700193", "l": "ALK mutants phosphorylate SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015495", "l": "gamma-aminobutyric acid:proton symporter activity"}, {"i": "REACT:R-HSA-428625", "l": "Vesicular inhibitory amino acid transport (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102664", "l": "indole-3-acetyl-leucine synthetase activity"}, {"i": "MetaCyc:RXN-2945"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055131", "l": "C3HC4-type RING finger domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000102", "l": "L-methionine secondary active transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51359", "l": "H2O + N-(9Z-octadecenoyl)-L-glutamine <=> (9Z)-octadecenoate + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798372", "l": "ATM phosphorylates DYRK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15064", "l": "2 a Fe(II)-siderophore + H(+) + NAD(+) <=> 2 a Fe(III)-siderophore + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004909", "l": "interleukin-1, type I, activating receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29624", "l": "alpha-maltopentaose + beta-maltose => alpha-maltohexaose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25556", "l": "9alpha-copalyl diphosphate = diphosphate + stemod-13(17)-ene"}, {"i": "EC:4.2.3.34", "l": "\"Stemod-13(17)-ene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052831", "l": "inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity"}, {"i": "REACT:R-HSA-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391157", "l": "p-4Y-SIRPA:CD47 binds SKAP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871266", "l": "YAP1 binds TEAD3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390438", "l": "FAR2 reduces PalmCoA to HXOL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62442", "l": "4-deoxy-6-O-methyl-L-threo-hex-4-enopyranuronate + [(1->4)-alpha-D-galacturonosyl methyl ester](n-1) => [(1->4)-alpha-D-galacturonosyl methyl ester](n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28409", "l": "H2O + XTP <=> H(+) + phosphate + XDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673756", "l": "Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952419", "l": "SMURFs ubiquitinate RUNX3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047280", "l": "nicotinamide phosphoribosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58120", "l": "ATP + L-seryl-[protein] = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043842", "l": "Kdo transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2214351", "l": "PLK1 phosphorylates GORASP1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61755", "l": "steviolbioside + UDP-alpha-D-glucose <=> H(+) + rebaudioside B + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9649108", "l": "HTR3A pentamer binds 5HT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45079", "l": "(9Z,12Z)-octadecadienoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] <=> (9Z,12Z)-18-hydroxyoctadecadienoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730835", "l": "Autophosphorylation of PKC-theta (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624112", "l": "CEBPA binds CDK4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047932", "l": "glucosamine N-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160874", "l": "HYAL1 hydrolyses (HA)50 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50722", "l": "FMN + H(+) + H2O + methanesulfonate => FMNH2 + methanesulfinate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28287", "l": "a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102009", "l": "proline dipeptidase activity"}, {"i": "MetaCyc:3.4.13.9-RXN"}, {"i": "EC:3.4.13.9", "l": "\"Xaa-Pro dipeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32864", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20091", "l": "CoA + H(+) + N-acetyl-L-leucine => acetyl-CoA + L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390912", "l": "HRH1 binds hist (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47285", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28655", "l": "glutathione S,S-dioxide + H2O = glutathione + H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27443", "l": "D-xylose + H(+) + NADH => NAD(+) + xylitol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18885", "l": "GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH"}, {"i": "EC:1.1.1.271", "l": "\"GDP-L-fucose synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59865", "l": "(indol-3-yl)butanoate + ATP + L-glutamine => (indol-3-yl)butanoyl-L-glutamine + AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003992", "l": "N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015362", "l": "high-affinity sodium:dicarboxylate symporter activity"}, {"i": "REACT:R-HSA-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59463", "l": "hexadecan-1-ol + NADP(+) <=> H(+) + hexadecanal + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9611277", "l": "P2RY12 binds P2RY12 antagonists (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43802", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10296", "l": "D-glyceraldehyde 3-phosphate + NADP(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789092", "l": "NOX2 generates superoxide anion from oxygen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50491", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55093", "l": "D-fructose + UDP-alpha-D-glucose => H(+) + sucrose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43292", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43831", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357845", "l": "RIPK1 is deubiquitinated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52239", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 <=> 3 A + Fe(2+) + 3 H2O + mycobilin b"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426489", "l": "RISC binds inexactly matching target RNAs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71303", "l": "RPE dimers isomerise RU5P to XY5P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420131", "l": "The PACAP receptor binds PACAP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264848", "l": "apoA-I binds to CUBN:AMN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39282", "l": "ATP + dodecanoate(out) + H2O <=> ADP + dodecanoate(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199935", "l": "MSK1 activates CREB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174097", "l": "Association of Emi1 with Cdh1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64664", "l": "a long-chain fatty acyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] = a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989774", "l": "Expression of AGT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "81.20444558259193", "identifiers": [{"i": "GO:0015205", "l": "nucleobase transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36448", "l": "ATP + glycyl-L-proline(out) + H2O => ADP + glycyl-L-proline(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 133 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939201", "l": "ESR dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27842", "l": "9H-carbazole + H(+) + NADPH + O2 = 2'-aminobiphenyl-2,3-diol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17059", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP] => a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.99.6", "l": "\"NAD(P)H-hydrate epimerase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070273", "l": "phosphatidylinositol-4-phosphate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2995330", "l": "COX10 transforms heme to heme O (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177923", "l": "Sustained activation of SRC kinase by SHP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177934", "l": "EGFR autophosphorylation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798749", "l": "Exocytosis of specific granule lumen proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21873", "l": "L-arginyl-[cytochrome c] + S-adenosyl-L-methionine => H(+) + N(omega)-methyl-L-arginyl-[cytochrome c] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36253", "l": "(E)-feruloyl-CoA + AMP + diphosphate => (E)-ferulate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29242", "l": "H(+)(in) + uracil(in) <=> H(+)(out) + uracil(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140761", "l": "sequestered tissue factor -> tissue factor (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19615", "l": "S-adenosyl-L-homocysteine + trimethylsulfonium => dimethyl sulfide + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66021", "l": "H2O2 + L-lysyl-[collagen] + L-methionyl-[collagen] => [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55308", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432956", "l": "BP230 is recruited to the hemidesmosome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-482772", "l": "Release of platelet cytosolic components (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56390", "l": "(4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983153", "l": "E1 mediated ubiquitin activation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847968", "l": "PTEN binds FRK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60875", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O <=> a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(7)-methyl-GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-166214", "l": "FA anion flip-flops to the opposite surface (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5082391", "l": "Trimerization of HSF1 in the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632759", "l": "TP53 binds the SCO2 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9612219", "l": "ERBB4s80 binds to SRC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66226", "l": "asc-DeltaC9-CoA + H2O2 => asc-C9-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042988", "l": "X11-like protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944250", "l": "Association of procollagen type XXV (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661625", "l": "FVIII is secreted (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433506", "l": "Phosphorylation of APS (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29146", "l": "a ubiquinol + 2 H(+)(in) + nitrate <=> a ubiquinone + 2 H(+)(out) + H2O + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625426", "l": "Retrograde IFT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868236", "l": "BAR domain proteins recruit dynamin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538822", "l": "Cytosolic PP2A dephosphorylates phosphorylated PER complexed with TIM and DCO (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33193", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA => a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112510", "l": "IL6ST is tyrosine phosphorylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44682", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15382", "l": "O2 + quercetin => 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63693", "l": "alcohol glucuronate acceptor + UDP-alpha-D-glucuronate => a beta-D-glucuronoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451505", "l": "Dissociation of phospho ERK2 :phospho MEK2 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357472", "l": "PAK1-3 autophosphorylates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55262", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936563", "l": "ISGylation of DDX58 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696822", "l": "AKR1B15 reduces EST17b to E1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26120", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16467", "l": "2 [Fe(II)cytochrome c553] + 2 H(+) + pyruvate => (R)-lactate + 2 [Fe(III)cytochrome c553]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944255", "l": "Association of procollagen type VII (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35420", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose => an anthocyanidin 3-O-sophoroside + 2 H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37152", "l": "(9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate => 1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "60.024245862843117", "identifiers": [{"i": "GO:0098772", "l": "molecular function regulator"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022141", "l": "Prolysyl oxidase activation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49580", "l": "(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate"}, {"i": "EC:4.6.1.17", "l": "\"Cyclic pyranopterin monophosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64658", "l": "(E)-sinapoyl-CoA + H(+) + NADPH => (E)-sinapoaldehyde + CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381545", "l": "Formation of the IGF:IGFBP5:ALS complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161794", "l": "Arachidonic acid is converted to HXA3/B3 by ALOX12 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.62", "l": "\"Multiple inositol-polyphosphate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070401", "l": "NADP+ binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018650", "l": "styrene monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029456", "l": "RAC1 and CDC42 activate PAK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56420", "l": "apo-[D-alanyl-carrier protein] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[D-alanyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44750", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) => 5-amino-1-(beta-D-ribosyl)imidazole + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31222", "l": "5-hydroxykynurenamine + CO2 <=> 5-hydroxy-L-kynurenine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12693", "l": "3,4-dihydroxypyridine + O-acetyl-L-serine = 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate + H(+)"}, {"i": "EC:2.5.1.52", "l": "\"L-mimosine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-392513", "l": "Rap1 signal termination by Rap1GAPs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3159259", "l": "MMAA:MUT binds AdoCbl (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60717", "l": "(1R,3R)-chrysanthemal + H2O + NADP(+) => (1R,3R)-chrysanthemate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50385", "l": "H(+) + oxidized coenzyme F420-(gamma-Glu)(n) + tetracycline => 5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433550", "l": "palmitoyl-CoA + serine => 3-dehydrosphinganine + CoASH + CO2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806732", "l": "GNLY binds the bacterial cell surface (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39272", "l": "(3R)-hydroxy-(15Z)-tetracosenoyl-CoA => (2E,15Z)-tetracosadienoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8936851", "l": "AHRR binds ARNT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63747", "l": "UDP-alpha-D-glucuronate + zolasartan <=> UDP + zolarsartan-1-N-beta-D-glucuronide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34414", "l": "cannabigerolate + O2 <=> cannabidiolate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25679", "l": "ATP + O-phospho-L-serine + tRNA(Cys) => AMP + diphosphate + O-phospho-L-seryl-tRNA(Cys)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45932", "l": "2-methylhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(3-methyl-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935766", "l": "miR-378 binds RUNX1 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044535", "l": "very-long-chain fatty acyl-CoA oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40088", "l": "22-hydroxydocosanoate + NAD(+) => 22-oxodocosanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209129", "l": "Ubiquitinated and phosphorylated ARM binds to and is degraded by the proteasome complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607734", "l": "PKC-delta translocates to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3065959", "l": "An unknown protease degrades hCBXs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42257", "l": "H(+) + hexanoyl-CoA + malonyl-[ACP] => 3-oxooctanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28912", "l": "H(+)(out) + L-lysine(out) => H(+)(in) + L-lysine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9022314", "l": "HIPK2 phosphorylates MECP2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16105", "l": "a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33539", "l": "ergosteryl ester + H2O = a carboxylate + ergosterol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65165", "l": "benzoyl-CoA + hexan-3-ol => CoA + hexan-3-yl benzoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13767", "l": "bromide + chloride + formaldehyde + 2 H(+) => bromochloromethane + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36406", "l": "a cholesterol ester + H2O <=> a fatty acid + cholesterol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25981", "l": "(5S)-albaflavenol + H(+) + NADPH + O2 => albaflavenone + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912408", "l": "Telomeres cluster at the nuclear membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65166", "l": "CoA + hexan-3-yl benzoate => benzoyl-CoA + hexan-3-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58642", "l": "a 5'-(5'-bisphosphomethyl)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine => a 5'-(5'-phospho)-ribonucleoside-RNA + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25624", "l": "geranylgeranyl diphosphate <=> tuberculosinyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58311", "l": "25-substituted-cholesterol + beta-D-glucosyl-N-(15Z-tetracosenoyl)-sphing-4E-enine <=> 25-substituted-cholesteryl beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18478", "l": "2,3-dihydroxybenzoate + O2 => 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990825", "l": "sequence-specific mRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685519", "l": "Polyadenylation of SARS-CoV-1 genomic RNA (plus strand) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46673", "l": "aldosterone + H(+) + NADPH => 5beta-dihydroaldosterone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19674", "l": "1,2,3-trihydroxybenzene + O2 => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40295", "l": "ATP + CoA + hexadecanedioate = AMP + diphosphate + hexadecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2299620", "l": "Collagen XI cross-links with collagen II (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44590", "l": "(9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-1D-myo-inositol => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59043", "l": "4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001632", "l": "leukotriene B4 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55011", "l": "(1R,4S)-1-hydroxylimonen-2-one + NADPH + O2 <=> (3S)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64413", "l": "H(+)(out) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) => H(+)(in) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60611", "l": "1-tetradecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2130194", "l": "ABL phosphorylates WAVEs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41191", "l": "1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30932", "l": "L-cysteine + O-acetyl-L-homoserine => acetate + H(+) + L,L-cystathionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33224", "l": "2-oxobutanoate + CoA + NAD(+) => CO2 + NADH + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626228", "l": "The distal appendage proteins recruit TTBK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944240", "l": "Association of procollagen type III (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26186", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + phosphate => 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52571", "l": "epitestosterone + UDP-alpha-D-glucuronate <=> epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419841", "l": "Light stimulates opsin receptors (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56325", "l": "(DNA)-(deoxyribonucleoside 5'-methylphosphotriester) + L-cysteinyl-[protein] => (DNA)-(deoxyribonucleoside 5'-phosphate) + H(+) + S-methyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43777", "l": "an N-(acyl)-sphingosylphosphocholine(in) => an N-(acyl)-sphingosylphosphocholine(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047141", "l": "glutathione-cystine transhydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0008504", "l": "monoamine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-453338", "l": "PGYM b dimer:AMP complex <=> PGYM dimer, b form + 2 AMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65860", "l": "A + Delta(1)-dihydrotestosterone + H2O = 17beta-hydroxyandrostan-1,3-dione + AH2"}, {"i": "EC:1.17.99.11", "l": "\"3-oxo-Delta(1)-steroid hydratase/dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43651", "l": "H(+) + hexadecanoyl-CoA + malonyl-[ACP] <=> 3-oxooctadecanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28119", "l": "di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose => D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32946", "l": "a 1,2-diacyl-sn-glycerol + CDP-ethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.26", "l": "\"Beta-fructofuranosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952996", "l": "E2F7 forms homodimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983077", "l": "STAT3 binds TSLP:IL7R:CRLF2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31868", "l": "(S)-2,3-epoxysqualene => baccharis oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031278", "l": "alpha-1,2-galactosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168136", "l": "Activated JNKs phosphorylate c-JUN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004170", "l": "dUTP diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64290", "l": "cladofulvin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 2 nataloe emodin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050236", "l": "pyridoxine:NADP 4-dehydrogenase activity"}, {"i": "MetaCyc:PYRIDOXINE-4-DEHYDROGENASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21211", "l": "H2O + O-phospho-L-serine <=> L-serine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17468", "l": "H2O + quercitrin <=> L-rhamnopyranose + quercetin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45746", "l": "7,8-dihydropteroate + H(+) + NADH => (6S)-5,6,7,8-tetrahydropteroate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54696", "l": "4-hydroxybenzoate + ATP + holo-[4-hydroxyphenylalkanoate synthase] = 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + diphosphate"}, {"i": "EC:6.2.1.50", "l": "\"4-hydroxybenzoate adenylyltransferase FadD22\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446391", "l": "Formation of the PINCH-ILK-parvin complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56961", "l": "a ribonucleoside 5'-triphosphate + pyruvate => a ribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44710", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13502", "l": "ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] => ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-182594", "l": "Association of INK4 family proteins with CDK4/6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16336", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP] <=> diphosphate + holo-[citrate lyase ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42596", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = prostaglandin G2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40163", "l": "D-glyceraldehyde + H2O + NADP(+) = (R)-glycerate + 2 H(+) + NADPH"}, {"i": "EC:1.2.1.89", "l": "\"D-glyceraldehyde dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004564", "l": "beta-fructofuranosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11767", "l": "H2O + methylguanidine <=> methylamine + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676593", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212614", "l": "Glutamine transport from astrocytes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42353", "l": "(R)-nicotine + A + H2O => (R)-6-hydroxynicotine + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48020", "l": "globoside Gb3Cer + H2O = beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50169", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 => N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033882", "l": "choloyl-CoA hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-744231", "l": "SLC35D2 exchanges UDP-sugars for UMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34189", "l": "(2Z)-2-hydroxypenta-2,4-dienoate + H(+) + succinate => (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.365", "l": "\"Protopanaxadiol-type ginsenoside-3-O-glucoside 2''-O-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17395", "l": "3-fumarylpyruvate => 3-maleylpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51293", "l": "a quinone + H2O + L-methionyl-[protein] => a quinol + L-methionyl-(S)-S-oxide-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34684", "l": "alpha-D-ribose 1-methylphosphonate 5-triphosphate + H2O => alpha-D-ribose 1-methylphosphonate 5-phosphate + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11389", "l": "an 11beta-hydroxysteroid + NADP(+) => an 11-oxosteroid + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58631", "l": "FADH2-C4alpha-hydroperoxide + H(+) + NADPH + rifamycin SV <=> FADH2 + H2O + NADP(+) + rifamycin SV hemiaminal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50949", "l": "a 2'-deoxycytidine in single-stranded DNA + H(+) + H2O => a 2'-deoxyuridine in single-stranded DNA + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676596", "l": "TRAF3 binds BAFFR:BAFF (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442749", "l": "CaMKK autophosphorylates in the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51822", "l": "AMP(in) + decanoyl-CoA(in) + diphosphate(in) + H(+)(in) => ATP(in) + CoA(in) + decanoate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5138459", "l": "WNT5A:FZD4 is endocytosed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692236", "l": "DMRT1 binds the FOXL2 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395364", "l": "LTBP4 binds TGF-Beta-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33302", "l": "[eIF5A protein]-L-lysine + spermidine <=> [eIF5A protein]-deoxyhypusine + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22593", "l": "(9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate => (10Z,15Z)-12-oxophytodienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685603", "l": "SAP and EAT2 binds SLAMF6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32959", "l": "H2O + L-isoleucine + NAD(+) = (S)-3-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34037", "l": "6'-oxoparomamine + H2O2 => O2 + paromamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38577", "l": "(9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22023", "l": "ATP + H2O + molybdate(out) <=> ADP + H(+) + molybdate(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24629", "l": "2 H2O + 3 NAD(+) + NH4(+) => 5 H(+) + 3 NADH + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371518", "l": "SIRT1 binds to HSF1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53863", "l": "7beta-hydroxy-3,12-dioxo-5beta-cholan-24-oate + NADP(+) <=> dehydrocholate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3315483", "l": "Phosphorylated SMAD2/3 MH2 Domain Mutants do not bind SMAD4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814153", "l": "ADO oxidises 2AET to HTAU (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964284", "l": "BTK in active Gq-BTK complex is activated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45353", "l": "9,10-epoxyoctadecanoate + H2O => 9,10-dihydroxyoctadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55632", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8985343", "l": "RUNX2 binds SOX9 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222128", "l": "NOC2L binds TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8856945", "l": "PP2A methylation by LCMT1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35153", "l": "(3-nitro-4-oxidophenyl)acetate + 2 H(+) + NADH => 4-hydroxy-3-nitrophenylacetaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22834", "l": "N-formyl-L-glutamate + NH4(+) => H2O + N-formimidoyl-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16093", "l": "(24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24R)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800315", "l": "MST1 binds MST1R (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110164", "l": "SMUG1 glycosylase mediated recognition and binding of uracil in DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44658", "l": "a monoacyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23855", "l": "catechol + O2 <=> cis,cis-muconate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018644", "l": "toluene 2-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50257", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183067", "l": "Localization of CBL:GRB2 to the membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32993", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 a 1-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53461", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30414", "l": "benzoyl-CoA + benzyl alcohol <=> benzyl benzoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879674", "l": "CD97 binds CD55 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47844", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73945", "l": "FAS-mediated dimerization of procaspase-8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50156", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29649", "l": "alpha-D-glucose 1-phosphate + alpha-maltotetraose => alpha-maltopentaose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018874", "l": "CYP monooxygenates EPA to 18(S)-HpEPE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47871", "l": "di-(9Z)-octadecenoylglycerol + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15106", "l": "kaempferol + S-adenosyl-L-methionine => H(+) + kaempferide + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63877", "l": "2-oxoglutarate + 3(1)-hydroxy-L-isoleucine + O2 => (4S)-3(1),4-dihydroxy-L-isoleucine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007816", "l": "RUNX2 binds HAND2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35881", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19370", "l": "L-histidyl-[protein] + S-adenosyl-L-methionine => H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396392", "l": "NOTCH1 PEST domain mutants bind HES1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5681987", "l": "LC3 is cleaved by ATG4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034537", "l": "2-hydroxy-3-methylbenzalpyruvate hydratase-aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21395", "l": "2-phenylacetaldehyde + H2O + NAD(+) <=> 2-phenylacetate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17574", "l": "demethylmacrocin + S-adenosyl-L-methionine => H(+) + macrocin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-481009", "l": "Exocytosis of platelet dense granule content (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004085", "l": "butyryl-CoA dehydrogenase activity"}, {"i": "EC:1.3.8.1", "l": "\"Short-chain acyl-CoA dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48979", "l": "5-methyl-phenazine-1-carboxylate + 2 H(+) + NADH + O2 <=> CO2 + H2O + NAD(+) + pyocyanin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53683", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 <=> 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2179413", "l": "Activated PKC-alpha  activate MMP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42186", "l": "17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH => 5alpha-androstane-3beta,17beta-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617867", "l": "HOXB4 gene is transcribed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2160874", "l": "HYAL1 hydrolyses (HA)50 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83660", "l": "Membrane-anchored TNF-alpha binds TNFR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38863", "l": "phosphate + sucrose 6(F)-phosphate = alpha-D-glucose 1-phosphate + beta-D-fructose 6-phosphate"}, {"i": "EC:2.4.1.329", "l": "\"Sucrose 6(F)-phosphate phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57836", "l": "H2O + O2 + thermospermine = 3-aminopropanal + H2O2 + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60232", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66994", "l": "3-methylpentanoyl-CoA + AMP + diphosphate => 3-methylpentanoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47437", "l": "(2E,7Z)-hexadecadienoyl-CoA + H2O => (3S)-hydroxy-(7Z-hexadecenoyl)-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12179", "l": "phenylethanolamine + S-adenosyl-L-methionine <=> H(+) + N-methylphenylethanolamine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33878", "l": "cholesteryl (9Z-octadecenoate) + H2O <=> (9Z)-octadecenoate + cholesterol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10772", "l": "6-phospho-beta-D-glucosyl-(1->4)-D-glucose + H2O = D-glucose + D-glucose 6-phosphate"}, {"i": "EC:3.2.1.86", "l": "\"6-phospho-beta-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60378", "l": "D-glucose(in) => D-glucose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730899", "l": "Oligomerization of BCL10 and MALT1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655268", "l": "Activated FGFR2 mutants phosphorylate FRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66389", "l": "ATP + H2O + prostaglandin E2(in) => ADP + H(+) + phosphate + prostaglandin E2(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70420", "l": "HK1,2,3,GCK phosphorylate Glc to form G6P (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39346", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA <=> (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40980", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O => 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694409", "l": "Nucleotide exchange on RAB1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20178", "l": "pyridoxine + UDP-alpha-D-glucose => 5'-O-beta-D-glucosylpyridoxine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434836", "l": "Syk/Lck phosphorylate LAT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033420", "l": "CUG codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36511", "l": "(9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA = (11Z)-3-oxoicosenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38880", "l": "a fatty acid(in) => a fatty acid(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73577", "l": "CAD hexamer transforms L-Gln to CAP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030945", "l": "protein tyrosine phosphatase activity, via thiol-phosphate intermediate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009309", "l": "RUNX2 binds STUB1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23276", "l": "2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde"}, {"i": "EC:4.1.2.12", "l": "\"2-dehydropantoate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46605", "l": "[HPr protein]-O-phospho-L-serine + H(+) + phosphate => [HPr protein]-L-serine + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849900", "l": "SALMs1-3 bind each other in cis interactions (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28403", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A => ADP + H(+) + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42559", "l": "uridine(2819) in 21S rRNA <=> pseudouridine(2819) in 21S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15678", "l": "5-aminopentanamide + H2O => 5-aminopentanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57906", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700647", "l": "Active ALK phosphorylates SRC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2029471", "l": "Hydrolysis of PC to PA by PLD (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12078", "l": "an aromatic aldehyde + H(+) + NADH => an aromatic primary alcohol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32628", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) => 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534378", "l": "Hv1 Mediated H+ Permeability (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63667", "l": "(S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADPH <=> H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22681", "l": "dCTP + H(+) + H2O => dUTP + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61156", "l": "3'-dephospho-CoA + GTP = CoA + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932334", "l": "KEAP1:CUL3:RBX1:NFE2L2 dissociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26025", "l": "(3E,5E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal => 8'-apo-beta-carotenol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60421", "l": "H2O + triglucosyl-enterobactin => [N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]3 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47396", "l": "H2O + octadecanoate ester = an aliphatic alcohol + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047888", "l": "fatty acid peroxidase activity"}, {"i": "RHEA:23960", "l": "H(+) + 2 H2O2 + hexadecanoate = CO2 + 3 H2O + pentadecanal"}, {"i": "EC:1.11.1.3", "l": "\"Fatty-acid peroxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31264", "l": "but-3-ynal + H(+) + pyrroloquinoline quinol => but-3-yn-1-ol + pyrroloquinoline quinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613352", "l": "PLINs bind HSPA8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654569", "l": "Activated FGFR1 binds FRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050215", "l": "propanediol dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943279", "l": "GGT dimers hydrolyse GSH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5684887", "l": "Activation of CHEK1 at resected DNA DSBs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015225", "l": "biotin transmembrane transporter activity"}, {"i": "RHEA:28458", "l": "biotin(in) = biotin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168888", "l": "Alpha1-Microglobulin binds heme (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11526", "l": "cholest-4-en-3-one + H(+) + NADPH => 5beta-cholestan-3-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672973", "l": "MAP2Ks phosphorylate MAPKs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18579", "l": "3-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine => 3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685242", "l": "CHEK1 phosphorylates BRCA2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050113", "l": "inositol oxygenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008444", "l": "CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445079", "l": "Phosphorylation of L1 by ERK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26220", "l": "abieta-7,13-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> abieta-7,13-dien-18-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49811", "l": "a quinone + butan-1-ol <=> a quinol + butanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61069", "l": "acetyl-CoA + horhammericine => 19-O-acetylhorhammericine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036185", "l": "13-lipoxin reductase activity"}, {"i": "REACT:R-HSA-2161844", "l": "15k-LXA4 is reduced to dhk-LXA4 by PTGR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730837", "l": "Recruitment of GRB2:SOS to p-10Y-NTAL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354097", "l": "Activation of Talin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44558", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-hexaprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13061", "l": "O2 + S-sulfanylglutathione = glutathione S,S-dioxide + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63884", "l": "H2O2 + L-tyrosine = H2O + L-dopa"}, {"i": "EC:1.11.2.6", "l": "\"L-tyrosine peroxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15594", "l": "amicoumacin A 2-phosphate + H2O => amicoumacin A + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102472", "l": "eriodictyol 2-hydroxylase activity"}, {"i": "RHEA:57596", "l": "(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-2-hydroxyeriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "MetaCyc:RXN-14077"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044540", "l": "L-cystine L-cysteine-lyase (deaminating)"}, {"i": "RHEA:24927", "l": "H2O + L-cystine = NH4(+) + pyruvate + S-sulfanyl-L-cysteine"}, {"i": "EC:4.4.1.35", "l": "\"L-cystine beta-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60626", "l": "2 (9Z)-octadecenoate + 2 H(+) + sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19425", "l": "H(+) + imidazole-4-acetate + NADH + O2 = 5-hydroxyimidazole-4-acetate + H2O + NAD(+)"}, {"i": "EC:1.14.13.5", "l": "\"Imidazoleacetate 4-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61915", "l": "ATP + H2O + voriconazole(in) <=> ADP + H(+) + phosphate + voriconazole(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035302", "l": "ecdysteroid 25-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19610", "l": "adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031695", "l": "alpha-2B adrenergic receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41981", "l": "3alpha-hydroxy-5alpha-pregnan-20-one + NAD(+) => 5alpha-pregnane-3,20-dione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8939204", "l": "ESTG binds ESR1:chaperone complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603554", "l": "NTRK3(496-641):NELFB translocates to mitochondrion (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853800", "l": "ARTN binds RET:GFRA1,GFRA3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691131", "l": "CANDI binds CUL1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018494", "l": "FOXA1 and GATA3 bind TFF genes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950731", "l": "CRLF1:IL27 translocates to the extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062062", "l": "oligosaccharyltransferase complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814695", "l": "PERP binds desmosomes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8955844", "l": "RBKS phosphorylates ribose to R5P (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13655", "l": "[6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose => [6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190682", "l": "Connexin synthesis (generic) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35072", "l": "4-methylphenol(in) => 4-methylphenol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65696", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine = a diacylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686587", "l": "ABL1 phosphorylates RAD52 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23714", "l": "H(+) + NADPH + pregnan-21-al => NADP(+) + pregnan-21-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58338", "l": "a 4-hydroxynonenal + H(+) + NADPH => a 4-hydroxynonen-1-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140696", "l": "factor V -> factor Va + factor V activation peptide (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052740", "l": "1-acyl-2-lysophosphatidylserine acylhydrolase activity"}, {"i": "RHEA:18689", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}, {"i": "EC:3.1.1.32", "l": "\"Phospholipase A(1)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050094", "l": "methionine-glyoxylate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419841", "l": "Light stimulates opsin receptors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54148", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene = 1-hydroxy-all-trans-1,2-dihydro-neurosporene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373746", "l": "SEMA4D interacts with CD45 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012835", "l": "GDIs block activation of RHOA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58130", "l": "AH2 + alstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => A + O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190265", "l": "FGFR4 binds to FGF (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21203", "l": "2-oxoglutarate + L-lysine <=> (S)-2-amino-6-oxohexanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799431", "l": "TP53 binds HIPK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40120", "l": "H2O + tetradecanoyl-CoA => CoA + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114558", "l": "Thrombin-activated PARs activate Gq (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005148", "l": "prolactin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63725", "l": "candesartan + UDP-alpha-D-glucuronate => candesartan O-beta-D-glucuronoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14514", "l": "ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine => ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30774", "l": "guanosine + H2O <=> D-ribose + guanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-844619", "l": "AIM2 binds dsDNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65336", "l": "chrodrimanin T + H(+) + NADPH + O2 = chrodrimanin A + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31799", "l": "4-amino-5-aminomethyl-2-methylpyrimidine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10644", "l": "2-oxo-2H-pyran-4,6-dicarboxylate + H2O = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+)"}, {"i": "EC:3.1.1.57", "l": "\"2-pyrone-4,6-dicarboxylate lactonase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102343", "l": "3-hydroxy-arachidoyl-CoA dehydratase activity"}, {"i": "MetaCyc:RXN-13302"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790905", "l": "Box H/ACA snoRNP transforms uridine to pseudouridine in pre-rRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55849", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA => [(2->6)-alpha-D-glucosyl-(1->4)-N,7-O-diacetyl-alpha-D-neuraminosyl](n) + n CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21632", "l": "2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O"}, {"i": "EC:1.10.3.1", "l": "\"Catechol oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22055", "l": "A + H2O + NH4(+) <=> AH2 + H(+) + hydroxylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202168", "l": "Phosphorylation of ZAP-70 by Lck (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164509", "l": "Binding of gp120 of ENV oligomer to the host CD4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420265", "l": "AMY1-3 bind IAPP(34-70) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11887", "l": "3'-phosphoadenylyl sulfate + cortisol <=> adenosine 3',5'-bisphosphate + cortisol 21-sulfate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65909", "l": "3-hydroxy-L-kynurenine + pyruvate => H2O + L-alanine + xanthurenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40527", "l": "2 a ubiquinol + 4 H(+)(in) + O2(in) = 2 a ubiquinone + 4 H(+)(out) + 2 H2O(in)"}, {"i": "EC:7.1.1.7", "l": "\"Ubiquinol oxidase (electrogenic, proton-motive force generating)\""}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0106260", "l": "DNA-DNA tethering activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19617", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9654533", "l": "KRAS4B recycles to the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21864", "l": "an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)"}, {"i": "RHEA:25245", "l": "(R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)"}, {"i": "EC:3.1.2.6", "l": "\"Hydroxyacylglutathione hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19435", "l": "6-phospho-D-gluconate + ADP + H(+) => ATP + D-gluconate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53021", "l": "a plastoquinone + an L-alpha-amino acid + H2O => a 2-oxocarboxylate + a plastoquinol + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51027", "l": "H(+) + NADH + O2 + toluene-4-sulfonate <=> 4-(hydroxymethyl)benzenesulfonate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34735", "l": "a fatty acyl-CoA + sphinganine = an N-acylsphinganine + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168376", "l": "STIM1 oligomerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61056", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + lochnericine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203979", "l": "Coat Assembly (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607725", "l": "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351429", "l": "Association of 53BP1 with gamma H2AX at double strand break (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-706479", "l": "TAK1 is activated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052739", "l": "phosphatidylserine 1-acylhydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20416", "l": "glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine <=> glucuronoxylan 4-O-methyl-D-glucuronate + n H(+) + n S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13341", "l": "a menaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + an 8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine"}, {"i": "RHEA:57700", "l": "a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.350", "l": "\"Menaquinone C(8)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63700", "l": "mycophenolate + UDP-alpha-D-glucuronate = mycophenolic acid O-acyl-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629918", "l": "NEIL1 translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0016869", "l": "intramolecular transferase activity, transferring amino groups"}, {"i": "EC:5.4.3.-", "l": "\"Transferring amino groups\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9604328", "l": "AKT1 phosphorylates NOTCH4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875374", "l": "MET binds LRIG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990525", "l": "BIR domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37375", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189439", "l": "ALAD condenses 2 dALAs to form PBG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16604", "l": "L-aspartate <=> fumarate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16731", "l": "catechol + H(+) + NADPH => (1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090432", "l": "myristoyl-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35795", "l": "2'-deamino-2'-hydroxyneamine + UDP-alpha-D-kanosamine = H(+) + kanamycin A + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17175", "l": "glutathione + spermidine => glutathionylspermidine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43171", "l": "adenosine(34) in tRNA + H(+) + H2O <=> inosine(34) in tRNA + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.120", "l": "\"Oligoxyloglucan beta-glycosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22650", "l": "apo-[cytochrome c] + heme b => holo-[cytochrome c]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35444", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-xylose => an anthocyanidin 3-O-beta-D-sambubioside + 2 H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "70.769338388976067", "identifiers": [{"i": "GO:0008092", "l": "cytoskeletal protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70241", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24051", "l": "phosphate + sucrose <=> alpha-D-glucose 1-phosphate + D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15956", "l": "agmatine + ATP <=> ADP + 2 H(+) + N(4)-phosphoagmatine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2262743", "l": "Defective IDS does not hydrolyse dermatan sulfate (Chebi:63517 chain) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981621", "l": "Neuroglobin:oxygen dissociates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8986258", "l": "SLIT2:ROBO1 binds CXCR4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9640195", "l": "RRAGA,B hydrolyzes GTP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102700", "l": "alpha-thujene synthase activity"}, {"i": "MetaCyc:RXN-5105"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164840", "l": "ADP and Pi bind to ATPase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13087", "l": "CoA + L-2-acetamido-6-oxoheptanedioate => (S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11238", "l": "propane-1,3-diamine + sym-homospermidine => putrescine + spermidine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047038", "l": "D-arabinitol 2-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418553", "l": "cAMP degradation by Phosphodiesterases (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807106", "l": "PTEN undergoes monoubiquitination (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65212", "l": "(2E)-dodecenoyl-CoA + H2O = (2E)-dodecenoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134800", "l": "STING dimerization (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9690461", "l": "FKBP1A binds tacrolimus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008842", "l": "diphosphate-purine nucleoside kinase activity"}, {"i": "MetaCyc:2.7.1.143-RXN"}, {"i": "EC:2.7.1.143", "l": "\"Diphosphate-purine nucleoside kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13565", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol = 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H(+)"}, {"i": "EC:2.7.8.12", "l": "\"Teichoic acid poly(glycerol phosphate) polymerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444661", "l": "HCAR2 binds HCAR2 ligands (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51615", "l": "(R)-2-hydroxyglutarate + oxaloacetate <=> (R)-malate + 2-oxoglutarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31011", "l": "(S)-2,3-epoxysqualene = camelliol C"}, {"i": "EC:5.4.99.38", "l": "\"Camelliol C synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56206", "l": "3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + CMP + H(+) => CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706293", "l": "Active FLT3 binds to CBL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46305", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31689", "l": "(9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate => (9Z,12Z,15Z)-octadecatrienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592316", "l": "Initial activation of proMMP1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58921", "l": "(3S,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol => (+)-medicarpin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28054", "l": "2-oxobutanoate + CoA = formate + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602473", "l": "Autocatalytic activation of MMP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62923", "l": "1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol <=> 1alpha,2beta,25-trihydroxycholecalciferol + 3-hydroxypropanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6790038", "l": "Expression of HSP90B1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45446", "l": "H(+) + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate => H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35305", "l": "3-oxoisopentadecanoyl-CoA + H(+) + NADPH => 3-hydroxyisopentadecanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018761", "l": "bromoxynil nitrilase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849908", "l": "SALM4 binds flotillin-1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19106", "l": "4-aminobutanal + H2O + NAD(+) => 4-aminobutanoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21921", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine => Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009282", "l": "CDK1 phosphorylates RUNX2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696266", "l": "RND2 binds effectors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804099", "l": "HMGB1 binds LTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043892", "l": "methylglyoxal reductase (NADPH-dependent) activity"}, {"i": "MetaCyc:1.1.1.283-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043726", "l": "5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6795667", "l": "MDM2 translocates to the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683455", "l": "nsp16 binds VHL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31452", "l": "2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) => a cardiolipin + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381545", "l": "Formation of the IGF:IGFBP5:ALS complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029476", "l": "Role of myosins in phagosome formation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672980", "l": "Dissociation of RAS:RAF complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27492", "l": "2 D-sedoheptulose 7-phosphate <=> D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40636", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O => 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209903", "l": "Noradrenaline is converted to adrenaline (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.14", "l": "\"Zinc D-Ala-D-Ala carboxypeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380782", "l": "STAT binds to the active receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061658", "l": "URM1 conjugating enzyme activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730851", "l": "Phosphorylation of SLP-76 by p-SYK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41650", "l": "ADP + N(5)-phenyl-L-glutamine + phosphate => aniline + ATP + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050277", "l": "sedoheptulokinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130640", "l": "Recruitment of clathrin coated vesicle by Ii (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12595", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+) => a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30628", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) => (2S)-2-acetolactate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10353", "l": "an N-acetylarylalkylamine + H2O => acetate + an arylalkylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33346", "l": "glycine + O2 <=> 2-iminoacetate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654573", "l": "Activated FGFR1 binds SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46990", "l": "6-hydroxy-N-methylmyosmine + H2O2 => (R)-6-hydroxynicotine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12814", "l": "L-glutamate => D-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023171", "l": "Insulin secretory granule translocates across the cortical actin network (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004900", "l": "erythropoietin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62437", "l": "L-lyxonate => 2-dehydro-3-deoxy-L-arabinonate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211346", "l": "NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25220", "l": "acetyl-CoA + serotonin <=> CoA + H(+) + N-acetylserotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3134953", "l": "DHX36 or DHX9 binds MyD88 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40299", "l": "6-deoxyerythronolide B + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = erythronolide B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.15.35", "l": "\"6-deoxyerythronolide B hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29138", "l": "a menaquinol + 2 H(+)(in) + nitrate <=> a menaquinone + 2 H(+)(out) + H2O + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168923", "l": "Collagen type XVIII endostatin release (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806613", "l": "Keratin tetramers bind to form unit length filaments (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46481", "l": "4alpha-formyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 => 4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9611851", "l": "ADRB2 bind ADR,NAd (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1253343", "l": "WWOX binds ERBB4s80 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549322", "l": "OCT1 transports organic cations out of hepatic cells (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53007", "l": "2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1467269", "l": "Beta-defensins bind microbial membranes causing disruption (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-606349", "l": "Mis18 complex binds the centromere (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250220", "l": "Homodimerization of ERBB4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5622134", "l": "CRABP1 binds atRA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49996", "l": "cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = (25R)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.15.28", "l": "\"Cholest-4-en-3-one 26-monooxygenase  ((25R)-3-oxocholest-4-en-26-oate forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168947", "l": "Ligand binds to TLR10 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209187", "l": "Further phosphorylation of CI by CKIalphaepsilon (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25976", "l": "(+)-epi-isozizaene + H(+) + NADPH + O2 = (5S)-albaflavenol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46099", "l": "3-phenylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4 CO2 + 4 CoA + dihydropinosylvin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.26"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11951", "l": "4-hydroxybenzoyl-CoA + H2O <=> 4-hydroxybenzoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34067", "l": "5-phospho-alpha-D-ribose 1-diphosphate + H(+) + trans,octa-cis-decaprenyl phosphate = diphosphate + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose 5-phosphate"}, {"i": "EC:2.4.2.45", "l": "\"Decaprenyl-phosphate phosphoribosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17786", "l": "H(+) + L-glutamate => 4-aminobutanoate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685600", "l": "viral HA binds NCRI (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27540", "l": "4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde => ethanol + N,N-dimethyl-4-nitrosoaniline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "72.438504002572699", "identifiers": [{"i": "GO:0005198", "l": "structural molecule activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033766", "l": "2-hydroxyquinoline 8-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40819", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55184", "l": "2-oxoglutarate + 3-methylundecanoyl-CoA + O2 = 2-hydroxy-3-methylundecanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40549", "l": "2 H2O + novamethymycin + 4 oxidized [2Fe-2S]-[ferredoxin] => 10-deoxymethymycin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806957", "l": "MET receptor dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73806", "l": "AIR + CO2 => CAIR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047502", "l": "(+)-sabinol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694406", "l": "nsp13 binds DDX5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54623", "l": "2-oxoglutarate + eicosanoyl-CoA + O2 <=> 2-hydroxyeicosanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606789", "l": "ARSB hydrolyses DS (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814734", "l": "CDSN binds the cornified envelope (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54500", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = beta-geranylfarnesene + diphosphate"}, {"i": "EC:4.2.3.188", "l": "\"Beta-geranylfarnesene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51556", "l": "(S)-glaucine + S-adenosyl-L-methionine = (S)-N-methylglaucine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13775", "l": "(S)-stylopine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-cheilanthifoline + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40918", "l": "1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33794", "l": "H2O + sucrose 6(F)-phosphate <=> beta-D-fructose + beta-D-glucose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396399", "l": "Fibrillins bind BMPs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.4.11", "l": "\"Peptide-methionine (S)-S-oxide reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9006873", "l": "IL21 receptor STAT binding (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2399913", "l": "atRAL binds to RBP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19071", "l": "glutathione + methylglyoxal => (R)-S-lactoylglutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.37"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45084", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.130", "l": "\"Laurate 7-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62615", "l": "adenosine(1832) in 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(1832) in 18S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3782637", "l": "HDAC8 deacetylates histones (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24450", "l": "monoglucosyl-enterobactin + UDP => enterobactin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-372843", "l": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050115", "l": "myosin-light-chain-phosphatase activity"}, {"i": "MetaCyc:MYOSIN-LIGHT-CHAIN-PHOSPHATASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266350", "l": "CETP-mediated lipid exchange: LDL gains cholesterol ester (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010295", "l": "(+)-abscisic acid 8'-hydroxylase activity"}, {"i": "RHEA:12897", "l": "2-cis-(+)-abscisate + O2 + reduced [NADPH--hemoprotein reductase] = (+)-8'-hydroxyabscisate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.137", "l": "\"(+)-abscisic acid 8'-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48317", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b => a ganglioside GD1alpha + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65188", "l": "2-oxoglutarate + berkeleyone B + O2 = berkeleydione + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66354", "l": "(5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH => (3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451895", "l": "IL2RG binds JAK3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205244", "l": "Recruitment of CBL to KIT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58973", "l": "H2O + O2 + vanillin => 4-hydroxy-3-methoxybenzoate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29434", "l": "ATP + phosphate <=> ADP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031770", "l": "growth hormone-releasing hormone receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050628", "l": "2-oxopropyl-CoM reductase (carboxylating) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390329", "l": "Dephosphorylation of AKT by PP2A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51547", "l": "D-ribulose <=> D-xylulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202222", "l": "Phosphorylation of PKC theta (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23087", "l": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA <=> 7-methyl-3-oxooct-6-enoyl-CoA + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63153", "l": "an N-fatty acyl-taurine + H2O => a fatty acid + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404144", "l": "Parenchymal atROL translocates to HSCs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29369", "l": "cytidine + phosphate => CMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72095", "l": "Internal Methylation of mRNA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000433", "l": "SUMOylation of PML with SUMO3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41752", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028598", "l": "Phosphorylation of YAP by LATS1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43039", "l": "L-cysteine <=> 2-aminoprop-2-enoate + H(+) + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052884", "l": "all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11352", "l": "acetate + ATP = acetyl phosphate + ADP"}, {"i": "EC:2.7.2.1", "l": "\"Acetate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10979", "l": "H(+) + NADH + O2 + quinolin-2-ol <=> 5,6-dihydroquinoline-2,5,6-triol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38072", "l": "2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50243", "l": "[hyaluronan](n) <=> n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2214351", "l": "PLK1 phosphorylates GORASP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35991", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017441", "l": "PPARG gene expression is inhibited by MECP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33977", "l": "D-glucose + DIMBOA => DIMBOA beta-D-glucoside + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65067", "l": "dimethylallyl diphosphate + siccayne <=> diphosphate + pestalodiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49786", "l": "CoA + H(+) + taurochenodeoxycholate => chenodeoxycholoyl-CoA + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32530", "l": "N,N'-diacetylchitobiose + phosphate <=> N-acetyl-alpha-D-glucosamine 1-phosphate + N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102862", "l": "1-18:2-2-18:2-sn-glycerol-3-phosphocholine desaturase activity (SN2-18:3 forming)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444859", "l": "Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28615", "l": "(1Z,2S)-2-methylbutanal oxime => (2S)-2-methylbutanenitrile + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47803", "l": "4-methylsulfanyl-2-oxobutanoate + an aromatic L-alpha-amino acid <=> an aromatic oxo-acid + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62391", "l": "[(1->2)-beta-D-glucosyl](n) + H2O <=> [(1->2)-beta-D-glucosyl](n-2) + sophorose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.27", "l": "\"Thermolysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19108", "l": "4-aminobutanal + H2O + NAD(+) <=> 4-aminobutanoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863007", "l": "p25-bound CDK5 phosphorylates CDC25B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59676", "l": "D-maltotetraose + O2 = D-maltotetraono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002153", "l": "steroid receptor RNA activator RNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32142", "l": "ATP + CoA + malonate <=> AMP + diphosphate + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2428922", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847880", "l": "CYTH proteins bind ARF1:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31957", "l": "9beta-pimara-7,15-dien-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.221"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174235", "l": "Association of Emi1 with Cdc20 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683720", "l": "E protein gets palmitoylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38601", "l": "nicotinamide + nicotinate-adenine dinucleotide phosphate => NADP(+) + nicotinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004355", "l": "glutamate synthase (NADPH) activity"}, {"i": "MetaCyc:GLUTAMATESYN-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.202", "l": "\"Multisite-specific tRNA:(cytosine-C(5))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46607", "l": "[HPr protein]-O-phospho-L-serine + H(+) + phosphate <=> [HPr protein]-L-serine + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40466", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O <=> (9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-167415", "l": "G-protein alpha subunit is inactivated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016437", "l": "tRNA cytidylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061981", "l": "3-hydroxykynureninase activity"}, {"i": "RHEA:25143", "l": "3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + H(+) + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51851", "l": "8-methylmenaquinone-6 + succinate <=> 8-methylmenaquinol-6 + fumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018754", "l": "GDIs bind RHOH (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33674", "l": "2 [Fe(III)-cytochrome b5] + an N-(2,3-dihydroxyhexacosanoyl)-(4R)-hydroxysphinganine + H2O <=> 2 [Fe(II)-cytochrome b5] + 2 H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12211", "l": "4-methylumbelliferyl acetate + H2O <=> 4-methylumbelliferone + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641231", "l": "TLE recruits HDAC1 to WNT promoters (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46736", "l": "H2O + monoacyl-sn-glycero-3-phosphate = a monoacylglycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352268", "l": "Cleavage of Satb1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66678", "l": "4-farnesyl-3,5-dihydroxy-6-methylphthalide + diphosphate => (2E,6E)-farnesyl diphosphate + 5,7-dihydroxy-4-methylphthalide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5660980", "l": "p-S276-RELA binds RELB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981353", "l": "RASA1 stimulates RAS GTPase activity (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623415", "l": "FOXO1,FOXO3,FOXO4 bind IGFBP1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38385", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+) => 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802924", "l": "RAF is phosphorylated downstream of oncogenic RAS  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109862", "l": "MAP2K2 phosphorylates MAPK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12017", "l": "(2E,6E)-farnesyl diphosphate => (-)-germacrene D + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "73.946956196949927", "identifiers": [{"i": "GO:0016229", "l": "steroid dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202960", "l": "Caspase mediated cleavage of C-IAP1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41834", "l": "hexanoyl-[ACP] + NADP(+) => (2E)-hexenoyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37444", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080067", "l": "4-methylthiobutyl-desulfoglucosinolate sulfotransferase activity"}, {"i": "MetaCyc:RXNQT-4329"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65429", "l": "deamido-NAD(+)(in) + NAD(+)(out) => deamido-NAD(+)(out) + NAD(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12923", "l": "5-aminolevulinate + CO2 + CoA => glycine + H(+) + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.-.-", "l": "\"Other oxidoreductases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660706", "l": "Defective SLC6A3 does not cotransport DA, Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44608", "l": "3-(all-trans-nonaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-nonaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31749", "l": "3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH => 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38014", "l": "chlorophyll a + H2O <=> chlorophyllide a + H(+) + phytol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54609", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] => a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33882", "l": "2-deoxy-scyllo-inosamine + NADP(+) <=> 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788571", "l": "STAT1,STAT3,STAT6 bind IL13:IL13R type II (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "79.682896251205548", "identifiers": [{"i": "GO:0043178", "l": "alcohol binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44815", "l": "1,4-dihydroxy-2-naphthoate + all-trans-undecaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-11 + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202731", "l": "JAM3 dimerises (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33669", "l": "H2O + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+) => H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66259", "l": "ATP + H(+) + IC-asc-C7 <=> diphosphate + IC-asc-C7-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42181", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222533", "l": "ERK1/2-activated AP1 complex binds KDM6B promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60167", "l": "a guanosine in RNA + S-adenosyl-L-methionine <=> an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61129", "l": "O2 + quercetin + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + myricetin + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981093", "l": "IL12 bound to IL12R internalises (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379994", "l": "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352059", "l": "SLC6A15-mediated amino acid uptake (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047583", "l": "4-methyloxaloacetate esterase activity"}, {"i": "RHEA:10564", "l": "H2O + oxaloacetate 4-methyl ester = H(+) + methanol + oxaloacetate"}, {"i": "EC:3.1.1.44", "l": "\"4-methyloxaloacetate esterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45573", "l": "[(1->4)-beta-D-mannuronosyl](n) => [alginate](n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50433", "l": "AH2 + prostaglandin G1 => A + H2O + prostaglandin H1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58572", "l": "O-acetyl-15alpha-stemmadenine + O2 = H2O2 + precondylocarpine acetate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043758", "l": "acetate-CoA ligase (ADP-forming) activity"}, {"i": "MetaCyc:ACETATE--COA-LIGASE-ADP-FORMING-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65142", "l": "A + berkeleyone A + H2O => AH2 + O2 + protoaustinoid A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938887", "l": "PML binds RUNX1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450088", "l": "GLUT1 tetramer binds 4xATP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42420", "l": "2-oxoglutarate + L-lysine + O2 = (4R)-4-hydroxy-L-lysine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "34.527756103465613", "identifiers": [{"i": "GO:0003824", "l": "catalytic activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65149", "l": "phloretin + UDP-alpha-D-glucose => H(+) + trilobatin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42479", "l": "2,2',3-trihydroxydiphenyl ether + H(+) + O2 <=> 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856951", "l": "PP2A demethylation by PPME1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20811", "l": "acetyl-CoA + N-acetylneuraminate <=> CoA + N-acetyl-7-O-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141437", "l": "Formation of the MCC complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265160", "l": "Insulin secretory granule translocates to cell cortex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43845", "l": "(3beta)-hydroxy-cholest-5-en-26-al + NADPH + O2 => (3beta)-hydroxy-cholest-5-en-26-oate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48801", "l": "a neolactoside nLc4Cer + GDP-beta-L-fucose => a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14962", "l": "H2O + S-formylglutathione => formate + glutathione + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14802", "l": "(2R)-3-phosphoglycerate + ATP => (2R)-3-phospho-glyceroyl phosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19022", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine => an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951695", "l": "TEADs:YAP1 binds CTGF gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603087", "l": "Defective MAT1A does not transfer Ado from ATP to L-Met (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50635", "l": "a 2-(omega-methylsulfanyl)alkylmalate <=> a 2-(omega-methylsulfanyl)alkylmaleate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941701", "l": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40553", "l": "H(+) + phylloquinol + S-adenosyl-L-homocysteine => demethylphylloquinol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1297444", "l": "Binding of cAMP to HCN channels (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000074", "l": "TCII binds Cbl in the circulation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015386", "l": "potassium:proton antiporter activity"}, {"i": "RHEA:29467", "l": "H(+)(out) + K(+)(in) = H(+)(in) + K(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696358", "l": "TREM,CD300 binds lipids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864577", "l": "TFAP2C translocates to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35430", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside <=> cyanidin 3,5-di-O-beta-D-glucoside + E-sinapate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-398040", "l": "Gbeta:gamma activation of PLC beta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449058", "l": "Interleukin-1 family are secreted (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16256", "l": "(3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) <=> H(+) + NADH + phenanthrene-3,4-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37950", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48408", "l": "apo-[EntF peptidyl-carrier protein] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[EntF peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168777", "l": "Metalloprotease cleavage of GHR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163310", "l": "TFAM binds to mitochondrial promoters (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48693", "l": "1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O => H(+) + octanoate + octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0070008", "l": "serine-type exopeptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951486", "l": "CD46 binds C4b (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433711", "l": "Cis-homodimerization of nectins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37751", "l": "2-methyl-trans-aconitate = 2-methyl-cis-aconitate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55029", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + S-adenosyl-L-methionine => an N-methylornithine lipid + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64789", "l": "(E)-cinnamate + ATP + CoA => (E)-cinnamoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036400", "l": "short neuropeptide F receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53278", "l": "17beta-hydroxy-3-oxo-19-nor-5alpha-androst-1-ene + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-hydroxy-3,19-dioxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53481", "l": "3beta-hydroxy-5alpha-androstan-17-one + H(+) + NADPH => 5alpha-androstane-3beta,17beta-diol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617457", "l": "HOXB1 mRNA is translated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38627", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40275", "l": "hexadecanedioyl-CoA + O2 = (2E)-hexadecenedioyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19255", "l": "an N-acylsphing-4-enine + H(+) + phosphocholine => a sphingomyelin + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015052", "l": "beta3-adrenergic receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52526", "l": "20-hydroxy prostaglandin A1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin A1 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33971", "l": "5''-phosphoribostamycin + H2O = phosphate + ribostamycin"}, {"i": "EC:3.1.3.88", "l": "\"5''-phosphoribostamycin phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54887", "l": "L-arginyl-[protein] + NADP(+) <=> H(+) + N(omega)-(2'-phospho-ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952371", "l": "MDM2 binds RUNX3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36344", "l": "2-methylsulfanyl-N(6)-(Delta(2)-isopentenyl)adenosine in tRNA + H(+) + NADPH + O2 => 2-methylsulfanyl-N(6)-(cis-4-hydroxy-Delta(2)-isopentenyl)adenosine in tRNA + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000140", "l": "acylglycerone-phosphate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63048", "l": "H2O + pravastatin lactone = H(+) + pravastatin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10242", "l": "a (2E)-enoyl-[ACP] + H(+) + NADH => a 2,3-saturated acyl-[ACP] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53972", "l": "(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41259", "l": "L-tryptophan = (E)-3-(indol-3-yl)acrylate + NH4(+)"}, {"i": "EC:4.3.1.31", "l": "\"L-tryptophan ammonia lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10012", "l": "(R)-6-hydroxynicotine + H2O + O2 = 6-hydroxypseudooxynicotine + H2O2"}, {"i": "EC:1.5.3.6", "l": "\"(R)-6-hydroxynicotine oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1254251", "l": "ERBB4s80 binds YAP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37219", "l": "A + D-valine + H2O = 3-methyl-2-oxobutanoate + AH2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62990", "l": "dodecanoate + NH4(+) => dodecanamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13500", "l": "5-dehydro-2-deoxy-D-gluconate + ATP <=> 6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964274", "l": "G alpha (12) binds BTK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32598", "l": "7-isopropyl-4-methyloxepan-2-one + H2O <=> 6-hydroxy-3,7-dimethyloctanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17041", "l": "adenosine 5'-phosphosulfate + H2O = AMP + 2 H(+) + sulfate"}, {"i": "EC:3.6.2.1", "l": "\"Adenylylsulfatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11837", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-beta-lactosamine => CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617431", "l": "Retinoic acid activates HOXA1 chromatin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429157", "l": "ABCC4 accumulation of dense granule contents (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43678", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437230", "l": "L1-FGFR cis-heterodimerization (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033826", "l": "xyloglucan 4-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018501", "l": "cis-chlorobenzene dihydrodiol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44434", "l": "a 1,2-diacylglycerol + glycerol => 2 a 1-acylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39366", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA <=> (2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694433", "l": "MIA2 binds PREB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46489", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2106615", "l": "Removal of siRNA passenger strand (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56877", "l": "(R)-N-acetyl-1-phenylethylamine + H2O => (R)-1-phenylethylamine + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975865", "l": "IRAK4 autophosphorylation within the complex activated TLR:MyD88 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120152", "l": "calcium-dependent outer dynein arm binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36337", "l": "D-glucarate + 2 H(+) + NADH => D-glucuronate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.6.-.-", "l": "\"Catalysing the translocation of other compounds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35932", "l": "2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-glucose => 3''-deamino-3''-hydroxykanamycin X + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23205", "l": "chlorogenate + D-glucarate => 2-O-caffeoylglucarate + L-quinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3000433", "l": "SUMOylation of PML with SUMO3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.95"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11598", "l": "CO2 + UMP => H(+) + orotidine 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16737", "l": "H(+) + NADH + O2 + toluene = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)"}, {"i": "EC:1.14.12.11", "l": "\"Toluene dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38691", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3769383", "l": "CBY1 binds beta-catenin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40912", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9005994", "l": "TRPC3 gene transcription is stimulated by MECP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19616", "l": "dimethyl sulfide + S-adenosyl-L-methionine <=> S-adenosyl-L-homocysteine + trimethylsulfonium"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3323184", "l": "Defective HLCS does not biotinylate ACACA:Mn2+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3159259", "l": "MMAA:MUT binds AdoCbl (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26350", "l": "beta-L-galactose 1-phosphate + H2O => L-galactose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24417", "l": "2,4'-dihydroxyacetophenone + O2 => 4-hydroxybenzoate + formate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592310", "l": "Aggrecan degradation by ADAMTSs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29484", "l": "(2E,6E)-farnesyl diphosphate => (+)-beta-selinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031819", "l": "P2Y10 nucleotide receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12733", "l": "CO2 + diphosphate + nicotinate beta-D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate"}, {"i": "EC:2.4.2.19", "l": "\"Nicotinate-nucleotide diphosphorylase (carboxylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993802", "l": "HLCS biotinylates PC:Mn2+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983147", "l": "Release of E3 from polyubiquitinated substrate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11926", "l": "globoside Gb3Cer (d18:1(4E)) + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004419", "l": "hydroxymethylglutaryl-CoA lyase activity"}, {"i": "RHEA:24404", "l": "(3S)-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA"}, {"i": "EC:4.1.3.4", "l": "\"Hydroxymethylglutaryl-CoA lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34657", "l": "3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 H(+) + 2 S-adenosyl-L-homocysteine => C30 botryococcene + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010856", "l": "adenylate cyclase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11150", "l": "4 Fe(3+) + 2 H2O => 4 Fe(2+) + 4 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786190", "l": "CMBL hydrolyses OM to OLMS (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047657", "l": "alpha-1,3-glucan synthase activity"}, {"i": "MetaCyc:ALPHA-13-GLUCAN-SYNTHASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58679", "l": "NADPH + O2 + rifamycin SV <=> H2O + NADP(+) + rifamycin SV para-naphthoquinone carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797803", "l": "PTPRD binds SLITRK1-6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18722", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate => diphosphate + ent-13-epi-manoyl oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55993", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24571", "l": "a 6-phospho-beta-D-galactoside + H2O <=> an alcohol + D-galactose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43082", "l": "2 H(+) + H2O + oleanolate + oxidized [NADPH--hemoprotein reductase] => O2 + oleanolic aldehyde + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662620", "l": "MT3 binds cadmium (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35140", "l": "(E)-4-coumaroyl-CoA + (E)-feruloylacetyl-CoA + H2O => CO2 + 2 CoA + demethoxycurcumin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9649733", "l": "mature p21 RAS binds GDP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072547", "l": "tricoumaroylspermidine meta-hydroxylase activity"}, {"i": "MetaCyc:RXN-11260"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110322", "l": "Formation of Pol zeta complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "81.790986234327661", "identifiers": [{"i": "GO:0032036", "l": "myosin heavy chain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2134532", "l": "TGFBR2 phosphorylates TGFBR1 and PARD6A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170120", "l": "Translocation of Cdc25B to the cytoplasm (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48862", "l": "(5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate => 18-HEPE + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928583", "l": "FYN phosphorylates NMDAR2B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804955", "l": "ATM phosphorylates MDM2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201443", "l": "Type II receptor phosphorylates type I receptor (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9734730", "l": "ORC1 translocates to the nucleus (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65200", "l": "S-(acetaldehyde)-L-cysteine = (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12147", "l": "cyanidin 3-O-rutinoside + UDP-alpha-D-glucose <=> cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043910", "l": "ATP:coenzyme F420 adenylyltransferase activity"}, {"i": "MetaCyc:RXN-9385"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42942", "l": "5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine => cytidine(34) in tRNA precursor + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9724685", "l": "IgE binds omalizumab (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102138", "l": "7-oxatyphasterol synthase activity"}, {"i": "MetaCyc:RXN-11538"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33946", "l": "H(+) + 2 L-arginine + 3 NADH + 4 O2 <=> 4 H2O + 2 L-citrulline + 3 NAD(+) + 2 nitric oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937814", "l": "RUNX3 translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0086008", "l": "voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49584", "l": "D-erythrulose 1-phosphate = L-erythrulose 1-phosphate"}, {"i": "EC:5.1.3.38", "l": "\"D-erythrulose 1-phosphate 3-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36009", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52375", "l": "17beta-estradiol + 3'-phosphoadenylyl sulfate <=> 17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106373", "l": "3-deoxyglucosone dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13042", "l": "L-dopachrome => 5,6-dihydroxyindole-2-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27662", "l": "(S)-2-hydroxyglutarate + O2 = 2-oxoglutarate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950782", "l": "p-STAT1 binds p-STAT3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4088134", "l": "PLK1 phosphorylates FOXM1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990313", "l": "type-III cohesin domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985460", "l": "RUNX2 binds RB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008010", "l": "structural constituent of chitin-based larval cuticle"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17602", "l": "ATP + D-ribulose => ADP + D-ribulose 5-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16693", "l": "alpha-pinene oxide = (Z)-2-methyl-5-isopropylhexa-2,5-dienal"}, {"i": "EC:5.5.1.10", "l": "\"Alpha-pinene-oxide decyclase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072345", "l": "NAADP-sensitive calcium-release channel activity"}, {"i": "REACT:R-HSA-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2984258", "l": "NEK9 phosphorylates NEK6/NEK7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69053", "l": "RFC binding displaces Pol Alpha (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990624", "l": "guanyl nucleotide exchange factor inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395801", "l": "Phosphorylation of LAT by p-SYK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12457", "l": "CTP + D-ribitol 5-phosphate + H(+) => CDP-L-ribitol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018807", "l": "RAC3 GDIs block activation of RAC3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43611", "l": "agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O <=> 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22594", "l": "(10Z,15Z)-12-oxophytodienoate => (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36368", "l": "(S)-alpha-hydroxyglutarate-gamma-lactone + H2O => 2-hydroxyglutarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42731", "l": "S-adenosyl-L-methionine + uridine(2791) in 21S rRNA <=> 2'-O-methyluridine(2791) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65088", "l": "asperaculane E + O2 + reduced [NADPH--hemoprotein reductase] = asperaculane G + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2900747", "l": "NOTCH1 HD+PEST domain mutants bind DLL4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168641", "l": "TAK1 associated with the CBM complex phosphorylates IKKbeta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008876", "l": "quinoprotein glucose dehydrogenase activity"}, {"i": "RHEA:22152", "l": "a ubiquinone + D-glucose = a ubiquinol + D-glucono-1,5-lactone"}, {"i": "EC:1.1.5.2", "l": "\"Quinoprotein glucose dehydrogenase (PQQ, quinone)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3700984", "l": "TP53 family members stimulate BAX transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "65.896494305674821", "identifiers": [{"i": "GO:0060090", "l": "molecular adaptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097697", "l": "tRNA 5-carboxymethoxyuridine methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12611", "l": "6-methylthiopurine + H(+) + S-adenosyl-L-homocysteine => mercaptopurine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982637", "l": "Opsins binds G alpha-t (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18484", "l": "cyclohexylsulfamate + H2O <=> cyclohexylamine + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10611", "l": "(E)-cinnamate + O2 + reduced [NADPH--hemoprotein reductase] <=> (E)-4-coumarate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24913", "l": "L,L-cystathionine <=> 2-aminobut-2-enoate + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43239", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O <=> 1,2-dihexadecanoyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848395", "l": "IL18:IL18R1 binds IL18RAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45464", "l": "2 [Fe(II)-cytochrome b5] + eicosanoyl-CoA + 2 H(+) + O2 = (5Z)-eicosenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}, {"i": "EC:1.14.19.10", "l": "\"Icosanoyl-CoA 5-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31467", "l": "beta-D-glucosyl crocetin + UDP-alpha-D-glucose = bis(beta-D-glucosyl) crocetin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65936", "l": "beta-D-mannose = beta-D-glucose"}, {"i": "EC:5.1.3.44", "l": "\"Mannose 2-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350598", "l": "Arginine<=>Agmatine+CO2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64882", "l": "CMP + H(+) + phosphate => CDP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49432", "l": "cholate + lithocholoyl-CoA = choloyl-CoA + lithocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48390", "l": "alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+) => alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56500", "l": "(R)-3,5-bisphosphomevalonate + H(+) = CO2 + isopentenyl phosphate + phosphate"}, {"i": "EC:4.1.1.110", "l": "\"Bisphosphomevalonate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013069", "l": "Ubiquitination of DLL/JAG ligands upon binding to NOTCH3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001730", "l": "2'-5'-oligoadenylate synthetase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043800", "l": "hexulose-6-phosphate isomerase activity"}, {"i": "RHEA:25900", "l": "D-arabino-hex-3-ulose 6-phosphate = beta-D-fructose 6-phosphate"}, {"i": "EC:5.3.1.27", "l": "\"6-phospho-3-hexuloisomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25846", "l": "(R)-carvone + H(+) + NADH => (1S,5R)-carveol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70427", "l": "PGM:Mg2+ isomerise G1P to G6P (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209891", "l": "Dopamine is oxidised to noradrenaline (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44624", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP(+) = dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H(+) + NADPH"}, {"i": "EC:1.1.1.384", "l": "\"dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49287", "l": "8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP <=> CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20971", "l": "L-arabinonate <=> 2-dehydro-3-deoxy-L-arabinonate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27491", "l": "D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate => 2 D-sedoheptulose 7-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11083", "l": "dTMP + H2O <=> phosphate + thymidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18138", "l": "3beta-hydroxy-5alpha-pregnane-20-one + NADP(+) => 5alpha-pregnane-3,20-dione + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987214", "l": "p-STAT3 dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203553", "l": "eNOS binds NOSIP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11332", "l": "ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide"}, {"i": "EC:2.7.7.19", "l": "\"Polynucleotide adenylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114553", "l": "Activation of conventional Protein Kinase C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18012", "l": "glutaryl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-glutaryl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102190", "l": "4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity"}, {"i": "MetaCyc:RXN-11958"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62880", "l": "9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + AH2 = (3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + A"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080007", "l": "S-nitrosoglutathione reductase activity"}, {"i": "MetaCyc:RXN-10742"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023983", "l": "18(R)-RvE1, E2 and E3 translocate from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59347", "l": "D-maltose + O2 <=> D-maltobiono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36370", "l": "(S)-alpha-hydroxyglutarate-gamma-lactone + H2O <=> 2-hydroxyglutarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24506", "l": "4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) => 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30070", "l": "betaine aldehyde + H2O + NADP(+) <=> glycine betaine + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1974676", "l": "Beta defensin 103 activates TLR1:TLR2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50661", "l": "3-(3-methylsulfanyl)propylmalate => 2-(2-methylsulfanyl)propylmaleate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810392", "l": "TMEM55B translocates to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5336182", "l": "GPR37 binds prosaptide (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228811", "l": "NFKBIA variant is not phosphorylated within IkBA:NF-kappaB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55305", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18299", "l": "a primary amine + phthalate => a phtalamide + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051539", "l": "4 iron, 4 sulfur cluster binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48951", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate <=> 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4839638", "l": "CTNNB1 T41 mutants aren't phosphorylated by GSK3beta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15380", "l": "(S)-4,5-dihydroxypentane-2,3-dione + ATP <=> (2S)-2-hydroxy-3,4-dioxopentyl phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34116", "l": "carboxynorspermidine + H2O + NADP(+) => H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432054", "l": "Aquaporin-1 passively transports water out of cell (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17401", "l": "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = 4-carboxy-2-hydroxy-cis,cis-muconate + H2O"}, {"i": "EC:4.2.1.83", "l": "\"4-oxalmesaconate hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59837", "l": "H2O + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein] => 3-deoxyglucosone + L-lysyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21266", "l": "AH2 + glyoxylate => A + glycolate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39113", "l": "4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADPH => 4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65579", "l": "a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + UDP-alpha-D-glucuronate <=> an alpha-D-glucuronosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28106", "l": "galactitol 1-phosphate + NAD(+) = H(+) + keto-D-tagatose 6-phosphate + NADH"}, {"i": "EC:1.1.1.251", "l": "\"Galactitol-1-phosphate 5-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43363", "l": "an N-acylsphinganine + UDP-alpha-D-glucose <=> an N-acyl-beta-D-glucosyl-(1<->1')-sphinganine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13108", "l": "glycerol 2-phosphate + H2O <=> glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669250", "l": "PAK1 phosphorylates FLNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29783", "l": "ATP + H2O + L-cysteine(in) = ADP + H(+) + L-cysteine(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45466", "l": "(5Z)-eicosenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => 2 [Fe(II)-cytochrome b5] + eicosanoyl-CoA + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41603", "l": "1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20158", "l": "2n [Fe(III)cytochrome c] + a polyvinyl alcohol => 2n [Fe(II)cytochrome c] + an oxidized polyvinyl alcohol + 2n H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033756", "l": "Oplophorus-luciferin 2-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140311", "l": "protein sequestering activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2247511", "l": "STAB2:ligand is endocytosed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015517", "l": "galactose:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47824", "l": "H(+) + malonyl-[ACP] + octadecanoyl-[ACP] = 3-oxoeicosanoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46612", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol = (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390835", "l": "DRD1,5 bind DA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686088", "l": "CASP3 cleaves GSDMD (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0106130", "l": "purine phosphoribosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102358", "l": "daphnetin-8-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-13448"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709317", "l": "CO binds to free ferrohemoglobin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2186780", "l": "Degradation of Ub-SMAD7 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203977", "l": "SAR1 Activation And Membrane Binding (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16946", "l": "(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77081", "l": "Formation of the CE:GMP intermediate complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3149492", "l": "cob(II)alamin dissociates from MMACHC:MMADHC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420083", "l": "PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66228", "l": "asc-C13-CoA + O2 = asc-DeltaC13-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21350", "l": "10 CO2 + 10 CoA + 2 H2O + tetracenomycin F2 => 8 H(+) + 10 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9696266", "l": "RND2 binds effectors (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12206", "l": "3alpha-hydroxy-3,5-dihydromonacolin L carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63458", "l": "(2E,6E,10E)-geranylgeranyl phosphate + CDP + H(+) => (2E,6E,10E)-geranylgeraniol + CTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32180", "l": "(S)-2,3-dihydrodipicolinate + NAD(+) => dipicolinate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28449", "l": "1-deoxy-D-xylulose(in) <=> 1-deoxy-D-xylulose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20041", "l": "3-oxopropanoate + H2O + NADP(+) = 2 H(+) + malonate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49006", "l": "4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NADP(+) => aurachin C + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35839", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA = a cardiolipin + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51418", "l": "an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH => a (2S,3R)-flavan-3-ol + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20809", "l": "acetyl-CoA + N-acetylneuraminate => CoA + N-acetyl-7-O-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63994", "l": "5-fluorocytidine 5'-phosphate + ADP + H(+) => 5-fluorocytidine + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008772", "l": "[isocitrate dehydrogenase (NADP+)] kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32260", "l": "beta-D-fructose 1-phosphate + methylglyoxal => 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3364026", "l": "SET1 complex trimethylates H3K4 at the MYC gene (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.33"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090595", "l": "acetyl-CoA:L-lysine N6-acetyltransferase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944220", "l": "Association of procollagen type XXIII (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53126", "l": "delta-carotene => all-trans-lycopene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24399", "l": "scytalone <=> 1,3,8-trihydroxynaphthalene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-606289", "l": "New CENPA-containing nucleosomes are deposited at the centromere (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784861", "l": "HSPG binds LPL dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10449", "l": "2-oxoglutarate + a flavanone + O2 => a flavone + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9688832", "l": "MLKL binds PDCD6IP and SDCBP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48050", "l": "D-galactose + ganglioside GM2 (d18:1(4E)) => ganglioside GM1 (d18:1(4E)) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8873929", "l": "Casein kinase II phosphorylates STARD10 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41468", "l": "ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oryzalexin E + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.122", "l": "\"Oryzalexin E synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.204"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19487", "l": "beta-D-galactosyl-(1<->1)-sphing-4-enine + H(+) + UDP => sphing-4-enine + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57064", "l": "D-apionolactone + H2O = D-apionate + H(+)"}, {"i": "EC:3.1.1.115", "l": "\"D-apionolactonase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25803", "l": "H2O + N(1)-acetylspermine + O2 <=> 3-acetamidopropanal + H2O2 + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400282", "l": "CRY proteins are ubiquitinylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1606807", "l": "Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20812", "l": "(3S)-citryl-CoA = acetyl-CoA + oxaloacetate"}, {"i": "EC:4.1.3.34", "l": "\"Citryl-CoA lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12063", "l": "acetyl-CoA + 5 H(+) + 6 malonyl-CoA <=> 3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + 6 CO2 + 7 CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18527", "l": "3-methylbutanal + H(+) + NADPH => 3-methylbutanol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203712", "l": "eNOS associates with Caveolin-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42122", "l": "5alpha-androstan-3,17-dione + H(+) + NADPH => 17beta-hydroxy-5alpha-androstan-3-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875558", "l": "RAPGEF1 binds CRK,CRKL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39372", "l": "3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57386", "l": "(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA => (13S,14R)-1,13-dihydroxy-N-methylcanadine + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36284", "l": "1,7-dimethylxanthine + H(+) + NADPH + O2 => 7-methylxanthine + formaldehyde + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61581", "l": "(3S)-3-hydroxycyclohexane-1-carbonyl-CoA + NADP(+) => (5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23105", "l": "D-arabinose 5-phosphate => D-ribulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65150", "l": "H(+) + trilobatin + UDP => phloretin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879798", "l": "Expression of DEC1 (BHLHE40, BHLHB2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007447", "l": "E2F6 forms the PRC1L4 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12325", "l": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine => L-asparagine + N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43755", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein uS5] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein uS5]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950518", "l": "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62752", "l": "H2O + pravastatin lactone = (S)-2-methylbutanoate + H(+) + pravastatin diol lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928600", "l": "N-WASP binds ITSN1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008872", "l": "glucarate dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36755", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose = beta-D-Glc-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}, {"i": "EC:2.4.1.305", "l": "\"UDP-Glc:alpha-D-GlcNAc-glucosaminyl-diphosphoundecaprenol beta-1,3-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047950", "l": "glutathione oxidase activity"}, {"i": "MetaCyc:GLUTATHIONE-OXIDASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47316", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180540", "l": "Multi-ubiquitination of APOBEC3G (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37700", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + acetyl-CoA => 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29702", "l": "dimethyl sulfoxide(in) <=> dimethyl sulfoxide(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59387", "l": "2-oxoglutarate + 4-amino-L-phenylalanine <=> 3-(4-aminophenyl)pyruvate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49245", "l": "NAD(+) + resolvin E1 => 18-oxo-resolvin E1 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139917", "l": "tBID activates BAX protein (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010641", "l": "AKAP5 recruits PKA to ROBO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45356", "l": "H2O + N-(11Z-eicosenoyl)-sphing-4-enine = (11Z)-eicosenoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52990", "l": "[deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + propane-1,3-diamine => [deoxyhypusine synthase]-L-lysine + dehydrospermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32032", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + gamma-curcumene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44792", "l": "2-demethylmenaquinol-12 + S-adenosyl-L-methionine = H(+) + menaquinol-12 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675194", "l": "Activated MAPK phosphorylates RAF1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018527", "l": "cyclohexylamine oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10043", "l": "adenosine 3',5'-bisphosphate + H2O <=> AMP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61371", "l": "4-methylumbelliferone sulfate(in) + ATP + H2O <=> 4-methylumbelliferone sulfate(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59063", "l": "(20S)-ginsenoside Rg3 + H2O <=> (20S)-ginsenoside Rh2 + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40378", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + ATP <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32895", "l": "1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] = 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.56", "l": "\"1,8-cineole 2-exo-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21239", "l": "anthranilate + 2 H(+) + NADPH + O2 <=> 2,3-dihydroxybenzoate + NADP(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102224", "l": "GDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose hydrolase/2-epimerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3797226", "l": "Defective NHLRC1 does not ubiquitinate EPM2A (laforin) and PPP1R3C (PTG) (type 2B disease) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654651", "l": "Activated FGFR4 binds FRS3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201634", "l": "Caspase-mediated cleavage of FADK 1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30938", "l": "H2O + nicotinate beta-D-ribonucleotide <=> beta-D-ribosylnicotinate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-179421", "l": "Degradation of multiubiquitinated Nek2A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31353", "l": "(S)-2,3-epoxysqualene + H2O => lupan-3beta,20-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11986", "l": "A + H2O + testosterone acetate => AH2 + O2 + progesterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16147", "l": "2 [Fe(III)-cytochrome b5] + CMP-N-glycoloyl-beta-neuraminate + H2O => 2 [Fe(II)-cytochrome b5] + CMP-N-acetyl-beta-neuraminate + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0016728", "l": "oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor"}, {"i": "EC:1.17.4.-", "l": "\"With a disulfide as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66706", "l": "CoA + H(+) + mycophenolate => H2O + mycophenolyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30857", "l": "(S)-2,3-epoxysqualene + H2O => dammarenediol-II"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785762", "l": "IL13RA1 binds TYK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5252001", "l": "ATP1B4 binds SNW1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707659", "l": "Hemes:LY96 activates TLR4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55750", "l": "coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin] => coenzyme B + coenzyme M + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39916", "l": "1-O-alkyl-sn-glycero-3-phosphate + H2O => 1-O-alkyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61650", "l": "AMP + diphosphate + salicyl-[non-ribosomal peptide synthase] => ATP + holo-[non-ribosomal peptide synthase] + salicylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433415", "l": "Activation of RAC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44471", "l": "3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10446", "l": "(S)-laudanine + H(+) + S-adenosyl-L-homocysteine => (S)-reticuline + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404142", "l": "atROL binds RBP1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9727349", "l": "XDH dehydrogenates xanthine to form urate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52083", "l": "12-octadecanoyloxy-octadecanoate + H2O <=> 12-hydroxyoctadecanoate + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8847537", "l": "RAB43:GTP binds USP8NL (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019153", "l": "protein-disulfide reductase (glutathione) activity"}, {"i": "RHEA:21064", "l": "[protein]-disulfide + 2 glutathione = [protein]-dithiol + glutathione disulfide"}, {"i": "EC:1.8.4.2", "l": "\"Protein-disulfide reductase (glutathione)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850997", "l": "TRIM27 binds PTEN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5336182", "l": "GPR37 binds prosaptide (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029471", "l": "Hydrolysis of PC to PA by PLD (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39623", "l": "3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9664879", "l": "ATM:PEX5 binds ATM (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33837", "l": "(4R)-hydroxysphinganine + hexacosanoate => H2O + N-hexacosanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1861788", "l": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3782655", "l": "HDAC10 deacetylates histone (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.86", "l": "\"N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24499", "l": "4-O-deacetylvindoline + acetyl-CoA <=> CoA + vindoline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981355", "l": "RASA1 binds RAS:GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12906", "l": "alpha-D-mannose 1-phosphate + GDP + H(+) => GDP-alpha-D-mannose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614614", "l": "Cysteine is degraded to serine and H2S (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24980", "l": "3-hydroxy-4-methylanthranilate + ATP + H(+) = 3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate"}, {"i": "EC:2.7.7.97", "l": "\"3-hydroxy-4-methylanthranilate adenylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033403", "l": "UUA codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13188", "l": "H2O + 4 porphobilinogen <=> hydroxymethylbilane + 4 NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13441", "l": "H2O + L-cysteate = H(+) + NH4(+) + pyruvate + sulfite"}, {"i": "EC:4.4.1.25", "l": "\"L-cysteate sulfo-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60813", "l": "2-oxoglutarate + gibberellin A12 aldehyde + O2 => CO2 + gibberellin A12 + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-708349", "l": "Activated NOD2 oligomerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686359", "l": "SFTPs translocate from extracellular region to clathrin-coated vesicle (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38861", "l": "bis(beta-D-gentiobiosyl) crocetin + H(+) + UDP => beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36202", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycerol + H(+) + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950741", "l": "IL12B:IL23A translocates from ER lumen to extracellular space (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047342", "l": "galactose-1-phosphate thymidylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13321", "l": "(R)-3,3-dimethylmalate + NAD(+) = 3-methyl-2-oxobutanoate + CO2 + NADH"}, {"i": "EC:1.1.1.84", "l": "\"Dimethylmalate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163798", "l": "Furin cleaves pro-protein Z to protein Z (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40241", "l": "AMP + diphosphate + dodecanedioyl-CoA => ATP + CoA + dodecanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60824", "l": "H2O + P(1),P(2)-bis(5'-adenosyl) diphosphate = 2 AMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26053", "l": "glyceollin III + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32774", "l": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate <=> 2,6-dioxo-6-phenylhexa-3-enoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51749", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A => 4-amino-4-deoxy-beta-L-arabinopyranosyl-lipid A + di-trans,octa-cis-undecaprenyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30278", "l": "AH2 + H2O2 <=> A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102219", "l": "phosphogluco-amylopectin water dikinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37298", "l": "ATP + H2O + L-alanyl-L-threonine(out) <=> ADP + H(+) + L-alanyl-L-threonine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047961", "l": "glycine N-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6795460", "l": "SGK1 phosphorylates MDM2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41865", "l": "(2E)-decenoyl-[ACP] + H(+) + NADPH => decanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38214", "l": "hexadecane-1,2-diol + 2 hexadecanoyl-CoA <=> 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24250", "l": "glycine + pyruvate => glyoxylate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45810", "l": "(2S,3R)-dihydroxy-5-oxohexanedioate + H2O => galactarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655483", "l": "USP1 autocleavage (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55549", "l": "N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733545", "l": "Bile salts and acids bind ALB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201521", "l": "ALK autophosphorylation downstream of PTN and MDK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050624", "l": "vomilenine reductase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050564", "l": "N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800794", "l": "PIDD1 associates with CRADD (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36577", "l": "CoA + H(+) + N-(9Z-octadecenoyl)-sphinganine => (9Z)-octadecenoyl-CoA + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22607", "l": "D-mannose <=> D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20902", "l": "benzyl alcohol + CO2 + glycine => H(+) + H2O + N-benzyloxycarbonylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852324", "l": "GTSE1 binds PLK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047013", "l": "cholate 12-alpha dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15188", "l": "L-arginine + succinyl-CoA <=> CoA + H(+) + N(2)-succinyl-L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63311", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 11-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24455", "l": "L-glutamyl-[protein] + S-adenosyl-L-methionine <=> [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63728", "l": "candesartan + UDP-alpha-D-glucuronate = candesartan-2-N-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53720", "l": "ATP + N-acetyl-D-muramate = ADP + H(+) + N-acetyl-alpha-D-muramate 1-phosphate"}, {"i": "EC:2.7.1.221", "l": "\"N-acetylmuramate 1-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.63", "l": "\"Meprin B\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2201338", "l": "TRAF3 binds TICAM1:activated TLR4 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63613", "l": "prunetin + UDP-alpha-D-glucuronate => prunetin-5-O-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654159", "l": "Activated FGFR2 binds PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50493", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17984", "l": "4,5alpha-dihydrocortisone + NADP(+) <=> cortisone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26487", "l": "H(+) + O-phospho-L-serine + sulfite => L-cysteate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52242", "l": "4 H(+) + 2 MnO2 => 2 H2O + 2 Mn(2+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64734", "l": "(11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849857", "l": "KLK5 cleaves and activates CELA2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39928", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + H2O => 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15253", "l": "cis-aconitate + H(+) = CO2 + itaconate"}, {"i": "EC:4.1.1.6", "l": "\"Cis-aconitate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18793", "l": "alpha-D-ribose 1-phosphate = D-ribose 5-phosphate"}, {"i": "RHEA:27658", "l": "2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate"}, {"i": "EC:5.4.2.7", "l": "\"Phosphopentomutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12750", "l": "3,4,5-trihydroxybenzoate + H(+) => 1,2,3-trihydroxybenzene + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13833", "l": "L-arginine + pyruvate = 5-guanidino-2-oxopentanoate + L-alanine"}, {"i": "EC:2.6.1.84", "l": "\"Arginine--pyruvate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23537", "l": "alpha-D-glucose 1-phosphate => alpha-D-glucose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55560", "l": "a hydroperoxyeicosatetraenoate = a hydroxy-epoxy-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11196", "l": "5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate"}, {"i": "EC:2.4.2.21", "l": "\"Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35732", "l": "sn-glycerol 3-phosphate + tetradecanoyl-CoA => 1-tetradecanoyl-sn-glycerol 3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.70"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033251", "l": "cephalosporinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28100", "l": "AMP + guanosine 3',5'-bis(diphosphate) => ATP + GDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003689", "l": "DNA clamp loader activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43471", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> (8Z,10E,14Z)-12-hydroperoxyeicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0008271", "l": "secondary active sulfate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17104", "l": "H2O + O-acyl-(R)-carnitine <=> (R)-carnitine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17652", "l": "acetyl-[ACP] + malonate <=> acetate + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0003684", "l": "damaged DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030281", "l": "structural constituent of cutaneous appendage"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39674", "l": "(9Z)-hexadecenoyl-CoA + AH2 + O2 <=> (9Z,12Z)-hexadecadienoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51710", "l": "H(+) + keto-D-tagatose + NADH => D-altritol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110218", "l": "Cleavage of uracil by TDG glycosylase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623366", "l": "NR1H2,3 binds the MYLIP gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65137", "l": "(9Z)-octadecenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15540", "l": "(R)-3-sulfolactate + NADP(+) <=> 3-sulfopyruvate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322431", "l": "XIAP binds TLE (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18246", "l": "3'-dephospho-CoA + ATP => ADP + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69005", "l": "Cdc6 protein is phosphorylated by CDK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22562", "l": "2'-hydroxyformononetin + 2 H(+) + NADPH => (3R)-vestitone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005005", "l": "transmembrane-ephrin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168376", "l": "STIM1 oligomerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428522", "l": "Inactivation of RAC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65459", "l": "2-methylbutan-1-ol + acetyl-CoA <=> 2-methylbutyl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25957", "l": "2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) => 3-dehydroquinate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44988", "l": "(R)-carnitine + 2-methylpropanoyl-CoA = CoA + O-isobutanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428231", "l": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50970", "l": "inosine(37) in tRNA(Ala) + NH4(+) => adenosine(37) in tRNA(Ala) + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047520", "l": "11-cis-retinyl-palmitate hydrolase activity"}, {"i": "RHEA:19697", "l": "11-cis-retinyl hexadecanoate + H2O = 11-cis-retinol + H(+) + hexadecanoate"}, {"i": "EC:3.1.1.63", "l": "\"11-cis-retinyl-palmitate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41945", "l": "[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP => [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65571", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39030", "l": "a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63494", "l": "menadiol + NADP(+) => H(+) + menadione + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32292", "l": "phosphoethanolamine + 3 S-adenosyl-L-methionine => 3 H(+) + phosphocholine + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110215", "l": "Cleavage of uracil by UNG glycosylase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21044", "l": "24-methylidenelophenol + S-adenosyl-L-methionine = (Z)-24-ethylidenelophenol + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.143", "l": "\"24-methylenesterol C-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070551", "l": "endoribonuclease activity, cleaving siRNA-paired mRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62237", "l": "a cytidine(6-4)cytidine in DNA => a cytidine dimer in DNA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43397", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936356", "l": "GUCY2C trimer binds sta1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50856", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874078", "l": "PTK2 autophosphorylates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8963915", "l": "1,25(OH)2D binds VDR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12004", "l": "indoxyl + UDP-alpha-D-glucose = H(+) + indican + UDP"}, {"i": "EC:2.4.1.220", "l": "\"Indoxyl-UDPG glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604550", "l": "HEY1 gene expression is stimulated by NOTCH4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030987", "l": "high molecular weight kininogen receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.99.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159005", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40451", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23785", "l": "a quinone + L-proline => (S)-1-pyrroline-5-carboxylate + a quinol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404131", "l": "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36462", "l": "glycyl-L-proline + H2O <=> glycine + L-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29874", "l": "ATP + H2O + thiosulfate(out) <=> ADP + H(+) + phosphate + thiosulfate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49404", "l": "beta-D-mannopyranosyl-(1->2)-D-mannopyranose + phosphate = alpha-D-mannose 1-phosphate + D-mannose"}, {"i": "EC:2.4.1.339", "l": "\"Beta-1,2-mannobiose phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52288", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19064", "l": "H2O + NADP(+) + nitrite <=> H(+) + NADPH + nitrate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034042", "l": "5-formyluracil DNA N-glycosylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5695964", "l": "ABHD14B hydrolyses PNPB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58253", "l": "H2O + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] => ADP-D-ribose + L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57845", "l": "fraxetin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sideretin (reduced form)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32688", "l": "(2E)-geranyl diphosphate => diphosphate + tricyclene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17328", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA <=> (S)-2-succinylamino-6-oxoheptanedioate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18050", "l": "2-oxoglutarate + N(2)-acetyl-L-ornithine => L-glutamate + N-acetyl-L-glutamate 5-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66206", "l": "(2E)-heptenoyl-CoA + H2O2 => heptanoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50750", "l": "naphthalene-1,2,4,8-tetrol => H2O + juglone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379464", "l": "COMT transfers Met to DOPAC to form HVA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6795290", "l": "TORC2 complex phosphorylates SGK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56193", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60723", "l": "(E)-hept-2-enal + H2O + NADP(+) <=> (E)-hept-2-enoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392530", "l": "p-S400-Cot phosphorylates NIK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9658253", "l": "RAS:GTP binds PI3K (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4167511", "l": "HLCS biotinylates ACACB (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15916", "l": "ATP + thiamine phosphate <=> ADP + thiamine diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54990", "l": "2 H2O(in) => 4 e(-) + 4 H(+)(in) + O2(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16924", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170824", "l": "glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1810457", "l": "ZBP1(DAI) recruits RIP1 and RIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49045", "l": "H(+) + NADH + O2 + protoasukamycin => 4-hydroxyprotoasukamycin + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45738", "l": "(2E)-hexenoyl-CoA => (3E)-hexenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710468", "l": "GSDME variant does not bind PIPs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730872", "l": "Activation of Calcineurin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351341", "l": "Exocytosis of Proactivator polypeptide (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31677", "l": "H(+) + NADPH + perakine => NADP(+) + raucaffrinoline"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047247", "l": "luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase activity"}, {"i": "RHEA:22116", "l": "luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] 4'-O-beta-D-glucuronide + UDP"}, {"i": "EC:2.4.1.191", "l": "\"Luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047766", "l": "carbamoyl-serine ammonia-lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014587", "l": "Transcription of ROBO3.2 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005144", "l": "interleukin-13 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14938", "l": "all-trans-antheraxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => all-trans-violaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351341", "l": "Exocytosis of Proactivator polypeptide (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39924", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + H2O => 1-O-octadecyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010489", "l": "UDP-4-keto-6-deoxy-glucose-3,5-epimerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15190", "l": "2 [Fe(III)cytochrome c553] + formate => 2 [Fe(II)cytochrome c553] + CO2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2106615", "l": "Removal of siRNA passenger strand (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071968", "l": "lipid A-core heptosyltransferase activity"}, {"i": "RHEA:30019", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A = ADP + H(+) + lipid A-core"}, {"i": "MetaCyc:RXN0-5127"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809309", "l": "MTMR6 binds MTMR9 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016941", "l": "natriuretic peptide receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28353", "l": "UDP-beta-L-arabinofuranose <=> UDP-beta-L-arabinopyranose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050104", "l": "L-gulonate 3-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983374", "l": "p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13905", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP"}, {"i": "EC:2.4.1.206", "l": "\"Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610735", "l": "NUMB binds ITCH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22162", "l": "a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] + CoA => 4-coumaroyl-CoA + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66182", "l": "ADP + bilirubin-glucuronoside(out) + H(+) + phosphate => ATP + bilirubin-glucuronoside(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49233", "l": "D-mannose(out) + N(pros)-phospho-L-histidyl-[protein] => D-mannose 6-phosphate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10044", "l": "cyclohexanol + NAD(+) = cyclohexanone + H(+) + NADH"}, {"i": "EC:1.1.1.245", "l": "\"Cyclohexanol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64767", "l": "S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine <=> 2-aminoprop-2-enoate + 3-methyl-3-sulfanylhexan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40555", "l": "dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2 = dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+)"}, {"i": "EC:1.14.13.187", "l": "\"L-evernosamine nitrososynthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50152", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58717", "l": "FADH2-C4alpha-hydroperoxide + NADH + rifampicin => FADH2 + H(+) + H2O + NAD(+) + rifampicin hemiaminal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45043", "l": "2 [Fe(III)cytochrome c] + hydroxylamine <=> 2 [Fe(II)cytochrome c] + 2 H(+) + nitroxyl"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65774", "l": "1-methyl-3-[4-(propan-2-yl)phenyl]urea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + isoproturon + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28034", "l": "[thioredoxin]-disulfide + dADP + H2O = [thioredoxin]-dithiol + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-434650", "l": "MATEs mediate extrusion of xenobiotics (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22590", "l": "1-pyrroline + H2O => 4-aminobutanal"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046980", "l": "tapasin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605723", "l": "Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004908", "l": "interleukin-1 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49016", "l": "aurachin C epoxide = 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655483", "l": "USP1 autocleavage (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730840", "l": "Activation of RAC1 by VAV (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047146", "l": "sterigmatocystin 7-O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55343", "l": "(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol <=> 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40606", "l": "1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55652", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2314569", "l": "GOLGA2 phosphorylated by CDK1 is unable to promote fusion of ER to Golgi transport vesicles with cis-Golgi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936729", "l": "sulfate is activated to APS (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211910", "l": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47386", "l": "acetate + H(+) + hydroquinone => 4-acetoxyphenol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22260", "l": "H2O + triacetate lactone = H(+) + triacetate"}, {"i": "EC:3.1.1.38", "l": "\"Triacetate-lactonase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12984", "l": "H2O + O2 + S-sulfanylglutathione <=> glutathione + 2 H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051407", "l": "glycerone phosphate:inorganic phosphate antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11158", "l": "3-methyl-2-oxobutanoate + H(+) + NADPH + NH4(+) => H2O + L-valine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803227", "l": "Dissociation of high activity BRAF complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60719", "l": "(1R,3R)-chrysanthemal + H2O + NADP(+) <=> (1R,3R)-chrysanthemate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66286", "l": "H(+) + tomatidine 3-O-beta-D-glucopyranoside + UDP => tomatidine + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.2", "l": "\"Exodeoxyribonuclease III\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57951", "l": "2-hydroxytoluene + H(+) + NADH + O2 <=> 3-methylcatechol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636008", "l": "NEIL3 resolves abasic site-induced ICLs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14491", "l": "a nucleoside 2'-phosphate + H(+) => a nucleoside 2',3'-cyclic phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9613497", "l": "Unwinding DNA for the nascent transcript (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9681294", "l": "IL6R binds IL6R inhibitors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114558", "l": "Thrombin-activated PARs activate Gq (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199154", "l": "CD200 binds to CD200R (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14939", "l": "all-trans-violaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => all-trans-antheraxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37451", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + eicosanoyl-CoA = 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34901", "l": "malonyl-CoA methyl ester + S-adenosyl-L-homocysteine => malonyl-CoA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57723", "l": "ATP + 4 H(+)(in) + H2O <=> ADP + 5 H(+)(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36879", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + AH2 + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37909", "l": "(8E,10S)-10-hydroperoxy-octadeca-8-enoate => (9Z)-octadecenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36418", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine <=> diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679028", "l": "JAK3 binds JAK3 inhibitors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28364", "l": "dGMP + diphosphate + H(+) => dGTP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49062", "l": "a long chain fatty alcohol + FMN + H(+) + H2O => a long-chain alkane + FMNH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60989", "l": "(E)-hex-2-en-1-ol + NAD(+) => (E)-hex--2-enal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48753", "l": "2-oxoglutarate + O2 + validamycin A => CO2 + H(+) + succinate + validamycin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11524", "l": "5beta-cholestan-3-one + NADP(+) = cholest-4-en-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605736", "l": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17317", "l": "chlorophyllide a + H(+) + phytyl diphosphate = chlorophyll a + diphosphate"}, {"i": "EC:2.5.1.62", "l": "\"Chlorophyll synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018510", "l": "phloroglucinol reductase activity"}, {"i": "KEGG.REACTION:R05308"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11193", "l": "an (S)-2-haloacid + H2O => a (2R)-2-hydroxycarboxylate + a halide anion + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46271", "l": "2 [Fe(II)-cytochrome b5] + an N-acyl-(4R)-4-hydroxysphinganine + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66732", "l": "ATP + H2O + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(in) = ADP + H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033488", "l": "Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55641", "l": "C-terminal L-cysteinyl-[HypE protein] + carbamoyl adenylate => AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34670", "l": "C30 botryococcene + S-adenosyl-L-methionine <=> 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18042", "l": "2 H2O + NH4(+) + 6 oxidized [2Fe-2S]-[ferredoxin] => 8 H(+) + nitrite + 6 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52537", "l": "adenosine + dGTP => AMP + dGDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-481009", "l": "Exocytosis of platelet dense granule content (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374673", "l": "L1 binds RanBPM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30970", "l": "9,9',15-tri-cis-zeta-carotene <=> 9,9'-di-cis-zeta-carotene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54240", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161792", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035175", "l": "histone kinase activity (H3-S10 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61261", "l": "H2O + L-glutamine + O2 => 2-oxoglutaramate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51941", "l": "(1E,2S)-2-methylbutanal oxime => (1Z,2S)-2-methylbutanal oxime"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016689", "l": "manganese peroxidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102667", "l": "indole-3-acetyl-beta-1-D-glucose hydrolase activity"}, {"i": "MetaCyc:RXN-3165"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205262", "l": "Direct recruitment of PI3K to p-KIT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659926", "l": "Defective SI does not hydrolyze Suc (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-481009", "l": "Exocytosis of platelet dense granule content (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847880", "l": "CYTH proteins bind ARF1:GTP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15870", "l": "2-oxoglutarate + D-alanine => D-glutamate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51503", "l": "ATP + N-acetyl-D-muramate <=> ADP + H(+) + N-acetyl-D-muramate 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38966", "l": "ATP + H2O + leukotriene C4(in) <=> ADP + H(+) + leukotriene C4(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9640195", "l": "RRAGA,B hydrolyzes GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006431", "l": "Expression of IFNG gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29926", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A <=> ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51351", "l": "acetyl-CoA + 10 AH2 + 2 H(+) + 7 malonyl-CoA + 5 S-adenosyl-L-methionine <=> 10 A + 7 CO2 + 8 CoA + dehydroprobetaenone I + 6 H2O + 5 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60007", "l": "(L-glutamyl)n+1-L-gamma-glutamyl-L-glutamyl-[protein] + H2O <=> (L-glutamyl)n-L-gamma-glutamyl-L-glutamyl-[protein] + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810234", "l": "General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23663", "l": "4-imidazolone-5-propanoate + H2O <=> N-formimidoyl-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050360", "l": "tryptophan 2'-dioxygenase activity"}, {"i": "RHEA:22620", "l": "H(+) + L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH4(+)"}, {"i": "EC:1.13.99.3", "l": "\"Tryptophan 2'-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21951", "l": "formamide + H2O <=> formate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34902", "l": "malonyl-CoA + S-adenosyl-L-methionine <=> malonyl-CoA methyl ester + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9650165", "l": "ASIC trimers bind H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-181450", "l": "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191303", "l": "FDPS dimer transfers IPPP to GPP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37147", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54714", "l": "3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine => N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379464", "l": "COMT transfers Met to DOPAC to form HVA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0002061", "l": "pyrimidine nucleobase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2197690", "l": "Detachment of WASP/WAVE (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17965", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + H(+) = (8Z,11Z,14Z)-heptadecatrienal + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25287", "l": "lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25438", "l": "(E,R)-alpha-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15226", "l": "alpha-D-glucose 1-phosphate + dTTP + H(+) => diphosphate + dTDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.6", "l": "\"Catalase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32816", "l": "Hg(2+)(in) => Hg(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10555", "l": "D-glucose + O2 <=> 2-dehydro-D-glucose + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36121", "l": "O-methyl gibberellin A9 + S-adenosyl-L-homocysteine => gibberellin A9 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14928", "l": "D-mannitol 1-phosphate + NADP(+) <=> D-mannose 6-phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21856", "l": "cyclohexa-1,5-diene-1-carbonyl-CoA + H2O = 6-hydroxycyclohex-1-ene-1-carbonyl-CoA"}, {"i": "EC:4.2.1.100", "l": "\"Cyclohexa-1,5-dienecarbonyl-CoA hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48632", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21566", "l": "a 3-oxoacyl-CoA + CoA => acetyl-CoA + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875451", "l": "MET phosphorylates CBL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951966", "l": "EP300 acetylates RUNX3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50792", "l": "18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = aldosterone + 2 H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0005432", "l": "calcium:sodium antiporter activity"}, {"i": "REACT:R-HSA-8949703", "l": "SLC8A3 (NCX3) exchanges sodium (cytosol) for calcium (mitochondrial intermembrane space) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23470", "l": "2,3-dihydroxybenzenesulfonate + NAD(+) + NH4(+) => 2-aminobenzenesulfonate + 2 H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001618", "l": "virus receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58065", "l": "O2 + reduced [NADPH--hemoprotein reductase] + xanthotoxin => 5-hydroxyxanthotoxin + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388814", "l": "Grb2 binds CD28 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928607", "l": "p-EPHs bind VAV2,3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23526", "l": "an alkyl cinnamate + beta-D-glucose => 1-O-(trans-cinnamoyl)-beta-D-glucose + an alcohol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247837", "l": "WNT ligands traffic to the Golgi (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031546", "l": "brain-derived neurotrophic factor receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047788", "l": "2-coumarate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28711", "l": "H(+)(in) + N-(4-aminobenzoyl)-L-glutamate(in) = H(+)(out) + N-(4-aminobenzoyl)-L-glutamate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27362", "l": "chloride + S-adenosyl-L-methionine => chloromethane + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21384", "l": "L-phenylalanine = (E)-cinnamate + NH4(+)"}, {"i": "EC:4.3.1.24", "l": "\"Phenylalanine ammonia-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5632738", "l": "DDIT4 binds 14-3-3 dimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803233", "l": "Dissociation of oncogenic RAS:RAF complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803989", "l": "Nitric oxide and O2 react to NO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14481", "l": "2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate"}, {"i": "EC:3.1.3.87", "l": "\"2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35355", "l": "3-hydroxyisopentadecanoyl-CoA = (2E)-13-methyltetradecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17944", "l": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate <=> 2-methyl-cis-aconitate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46590", "l": "calcidiol + H2O + 2 oxidized [adrenodoxin] => calciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849906", "l": "SALM1 binds NMDA receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34966", "l": "Na(+)(in) <=> Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6790454", "l": "SUMOylation of XPC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42607", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5679266", "l": "Beclin-1 complex translocates to the ER (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013024", "l": "RHOB binds effectors at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51335", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> 11-hydroperoxy-(8Z,12E,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14186", "l": "3-phenylpyruvate + H(+) => 2-phenylacetaldehyde + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53492", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out)"}, {"i": "EC:2.1.1.86", "l": "\"Tetrahydromethanopterin S-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102256", "l": "neoagarohexaose 1,3-alpha-3,6-anhydro-L-galactosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58658", "l": "a 5'-(5'-phosphomethyl)-ribonucleoside-RNA + S-adenosyl-L-homocysteine => a 5'-(5'-phospho)-ribonucleoside-RNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32438", "l": "dihydrocarvone + H(+) + NADPH + O2 <=> 4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35748", "l": "(2E,6E)-farnesyl diphosphate => 7-epizingiberene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "75.582117822819498", "identifiers": [{"i": "GO:0019200", "l": "carbohydrate kinase activity"}, {"i": "REACT:R-HSA-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448661", "l": "IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.43", "l": "\"Classical-complement-pathway C3/C5 convertase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247849", "l": "WLS dissociates from retromer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66135", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693111", "l": "RHOF auto-activates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40654", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61563", "l": "gibberellin A15 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> gibberellin A24 + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785594", "l": "FANCD2 binds FANCI (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983424", "l": "Budding of COPII coated vesicle (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0042923", "l": "neuropeptide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64091", "l": "acetyl-CoA + 9 H(+) + holo-[ACP] + 9 malonyl-CoA <=> 3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 9 CO2 + 10 CoA + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47291", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1067667", "l": "IL6 binds IL6R (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63507", "l": "daunorubicin + H(+) + NADPH <=> 13-dihydrodaunorubicin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23355", "l": "2-oxoglutarate + 4-aminobutanoate <=> L-glutamate + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29497", "l": "beta-eudesmol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953398", "l": "PIR oxygenates quercetin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56132", "l": "(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in DNA = a thymidine dimer in DNA"}, {"i": "EC:4.1.99.14", "l": "\"Spore photoproduct lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850534", "l": "PDCL promotes G-protein beta 5 folding (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442387", "l": "ZIP8 mediates zinc influx into cells (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63049", "l": "H2O + pravastatin lactone => H(+) + pravastatin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975594", "l": "PLB1 hydrolyses RPALM to atROL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981353", "l": "RASA1 stimulates RAS GTPase activity (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606839", "l": "Steryl sulfatase hydrolyses sulfate from steroid sulfates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29935", "l": "cytosine(in) + H(+)(in) = cytosine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24206", "l": "phosphate + sulfoacetaldehyde => acetyl phosphate + H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679775", "l": "COMT binds COMT Inhibitors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16633", "l": "guanosine(34) in tRNA + queuine = guanine + queuosine(34) in tRNA"}, {"i": "EC:2.4.2.64", "l": "\"tRNA-guanosine(34) queuine transglycosylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46159", "l": "15,9'-di-cis-phytofluene + a plastoquinone <=> 9,9',15-tri-cis-zeta-carotene + a plastoquinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-481044", "l": "Surface deployment of platelet alpha granule membrane components (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47811", "l": "epothilone D + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> epothilone B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45850", "l": "3-oxododecanoyl-CoA + H(+) + NADPH => (3R)-3-hydroxydodecanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14844", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> ent-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43411", "l": "sphinganine + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1<->1')-sphinganine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57074", "l": "CO2 + L-erythrulose 1-phosphate => 3-oxoisoapionate 4-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63485", "l": "2-oxoglutarate + L-prolyl-[protein] + O2 => CO2 + succinate + trans-4-hydroxy-L-prolyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390425", "l": "FAR1 reduces PalmCoA to HXOL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000986", "l": "bacterial-type cis-regulatory region sequence-specific DNA binding"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015501", "l": "glutamate:sodium symporter activity"}, {"i": "RHEA:29031", "l": "L-glutamate(in) + Na(+)(in) = L-glutamate(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5444523", "l": "Formation of MSH1:PMS2 Complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429992", "l": "PARN deadenylates mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018766", "l": "RHOU binds effectors at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66654", "l": "african-1-ene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25986", "l": "(5R)-albaflavenol + H2O + NADP(+) => (+)-epi-isozizaene + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50637", "l": "a 3-(omega-methylsulfanyl)alkylmalate => a 2-(omega-methylsulfanyl)alkylmaleate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008692", "l": "3-hydroxybutyryl-CoA epimerase activity"}, {"i": "RHEA:21760", "l": "(3S)-3-hydroxybutanoyl-CoA = (3R)-3-hydroxybutanoyl-CoA"}, {"i": "EC:5.1.2.3", "l": "\"3-hydroxybutyryl-CoA epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29135", "l": "a menaquinol + 2 H(+)(in) + nitrate = a menaquinone + 2 H(+)(out) + H2O + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54904", "l": "(2E,9Z)-hexadecadienoyl-[ACP] + H(+) + NADH = (9Z)-hexadecenoyl-[ACP] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34066", "l": "2-deoxystreptamine + UDP-alpha-D-glucose <=> 2'-deamino-2'-hydroxyparomamine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48938", "l": "CO2 + succinate + trans-4-hydroxy-L-prolyl-[Skp1 protein] => 2-oxoglutarate + L-prolyl-[Skp1 protein] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080083", "l": "beta-gentiobiose beta-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65386", "l": "(N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) => a 5'-(N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32159", "l": "AH2 + epoxyqueuosine(34) in tRNA = A + H2O + queuosine(34) in tRNA"}, {"i": "EC:1.17.99.6", "l": "\"Epoxyqueuosine reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.n3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25465", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + longifolene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51958", "l": "(Z)-2-methylpropanal oxime => (E)-2-methylpropanal oxime"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22517", "l": "ATP + taurocyamine => ADP + H(+) + N-phosphotaurocyamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60137", "l": "a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 => a (8S,9R)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018754", "l": "GDIs bind RHOH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14271", "l": "2 a 1,4-benzosemiquinone + NADP(+) => 2 a quinone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004590", "l": "orotidine-5'-phosphate decarboxylase activity"}, {"i": "RHEA:11596", "l": "H(+) + orotidine 5'-phosphate = CO2 + UMP"}, {"i": "EC:4.1.1.23", "l": "\"Orotidine-5'-phosphate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445064", "l": "Activation of Rac1 by VAV2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730837", "l": "Recruitment of GRB2:SOS to p-10Y-NTAL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23832", "l": "an N-acyl-D-mannosamine + ATP = ADP + an N-acyl-D-mannosamine 6-phosphate + H(+)"}, {"i": "RHEA:25253", "l": "ATP + N-acetyl-D-mannosamine = ADP + H(+) + N-acetyl-D-mannosamine 6-phosphate"}, {"i": "EC:2.7.1.60", "l": "\"N-acylmannosamine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65754", "l": "(3R)-3-hydroxy-L-glutamate + CO2 + succinate => 2-oxoglutarate + L-glutamate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427570", "l": "Group 3 - Selective Cl- transport (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33024", "l": "6-phospho-D-gluconate + NAD(+) => CO2 + D-ribulose 5-phosphate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683964", "l": "ATM phosphorylates EYA1-4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198669", "l": "p38MAPK phosphorylates MSK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678998", "l": "Endosomal TLRs pass through the Golgi (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2179413", "l": "Activated PKC-alpha  activate MMP3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31949", "l": "ent-isokauren-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-isokaurene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25441", "l": "(2E,6E)-farnesyl diphosphate => delta-selinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32080", "l": "(13E)-labda-7,13-dien-15-yl diphosphate + H2O => (13E)-labda-7,13-dien-15-ol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11899", "l": "7alpha-hydroxycholesterol + NAD(+) <=> 7alpha-hydroxycholest-4-en-3-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11363", "l": "2 2',3,4,4',6'-pentahydroxychalcone + 2 H(+) + O2 <=> 2 aureusidin + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51699", "l": "desmethylxanthohumol + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + xanthohumol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65845", "l": "ADP(out) + phosphate(in) => ADP(in) + phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419351", "l": "PAF receptor binds platelet activating factor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975098", "l": "MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336454", "l": "MMGT1 transports Mg2+ from cytosol to Golgi lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350377", "l": "Extracellular domains of STAN bind to each other in adjacent cells (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30624", "l": "A + all-trans-neurosporene => AH2 + all-trans-lycopene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34673", "l": "3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine => 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047244", "l": "N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-434650", "l": "MATEs mediate extrusion of xenobiotics (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20258", "l": "3-methyloxindole + NADP(+) => 3-methyleneoxindole + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806974", "l": "MET dimers autophosphorylate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694433", "l": "MIA2 binds PREB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2468040", "l": "Cohesin binds PDS5 and WAPAL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909732", "l": "Phosphorylation of STAT2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939129", "l": "miR-215 binds RUNX1 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018788", "l": "atrazine chlorohydrolase activity"}, {"i": "RHEA:11312", "l": "atrazine + H2O = chloride + H(+) + hydroxyatrazine"}, {"i": "EC:3.8.1.8", "l": "\"Atrazine chlorohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50251", "l": "ATP + D-ribose 5-phosphate + H(+) <=> ADP-D-ribose + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60320", "l": "N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696358", "l": "TREM,CD300 binds lipids (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66348", "l": "3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + A = (2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004345", "l": "glucose-6-phosphate dehydrogenase activity"}, {"i": "RHEA:15841", "l": "D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH"}, {"i": "EC:1.1.1.363", "l": "\"Glucose-6-phosphate dehydrogenase (NAD(P)(+))\""}, {"i": "EC:1.1.1.49", "l": "\"Glucose-6-phosphate dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1168376", "l": "STIM1 oligomerizes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0001671", "l": "ATPase activator activity"}, {"i": "REACT:R-HSA-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Homo sapiens)"}, {"i": "REACT:R-HSA-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.15"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35335", "l": "H(+) + isopentadecanoyl-CoA + malonyl-CoA = 3-oxoisoheptadecanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-349455", "l": "Phosphorylation of MDM4 by ATM (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390329", "l": "Dephosphorylation of AKT by PP2A (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64106", "l": "1D-myo-inositol hexakisphosphate + O-diphospho-L-seryl-[protein] => 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + O-phospho-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15033", "l": "O2 + pyridoxine = H2O2 + pyridoxal"}, {"i": "EC:1.1.3.12", "l": "\"Pyridoxine 4-oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018572", "l": "EGFR phosphorylates NOTCH3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.2.16", "l": "\"ABC-type ferric hydroxamate transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866851", "l": "CFTR transits to the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18622", "l": "2-oxoglutarate + a (2S)-flavan-4-one + O2 => a (2R,3R)-dihydroflavonol + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40880", "l": "2 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3221982", "l": "BANP binds TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17755", "l": "(S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine => S-(5-deoxy-D-ribos-5-yl)-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28576", "l": "H(+)(out) + sulfate(out) => H(+)(in) + sulfate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114354", "l": "SMAC binds XIAP:Caspase-7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15498", "l": "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate => 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31685", "l": "(-)-solanapyrone A => prosolanapyrone III"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174097", "l": "Association of Emi1 with Cdh1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878054", "l": "HIPK2 phosphorylates RUNX1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72139", "l": "Formation of the active Spliceosomal C (B*) complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58348", "l": "2 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 O2 = 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0023024", "l": "MHC class I protein complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50830", "l": "(17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E)-docosapentaenoate => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201622", "l": "Caspase-mediated cleavage of gelsolin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38898", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853307", "l": "FGFR3 fusions:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201611", "l": "Caspase-mediated cleavage of Rock-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33380", "l": "4-hydroxyeicosasphinganine 1-phosphate + H2O => (4R)-hydroxyeicosasphinganine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655289", "l": "Activated FGFR3 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19964", "l": "a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate <=> a 2'-deoxyribonucleoside 5'-phosphate + a ribonucleoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928654", "l": "Clathrin internalises EPH:EFN complexes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9008054", "l": "IL1F10 binds IL1RAPL1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33061", "l": "(R)-lipoamide + H(+) + NADH => (R)-dihydrolipoamide + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27742", "l": "2'-deoxyadenosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + adenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22802", "l": "obtusifoliol => cycloeucalenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-203613", "l": "depalmitoylation of eNOS (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66410", "l": "ADP + glutathione(out) + glycochenodeoxycholate(out) + H(+) + phosphate => ATP + glutathione(in) + glycochenodeoxycholate(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035368", "l": "selenocysteine insertion sequence binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3782535", "l": "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0016882", "l": "cyclo-ligase activity"}, {"i": "EC:6.3.3.-", "l": "\"Cyclo-ligases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47988", "l": "2-dehydro-3-deoxy-L-galactonate + NAD(+) = 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH"}, {"i": "EC:1.1.1.389", "l": "\"2-dehydro-3-deoxy-L-galactonate 5-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24331", "l": "7,8-dihydrofolate + ATP + formate <=> 10-formyldihydrofolate + ADP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373745", "l": "SDK1 homophillic interaction (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102819", "l": "bixin aldehyde dehydrogenase activity"}, {"i": "MetaCyc:RXN-8237"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17350", "l": "(2E)-geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole => 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9632038", "l": "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54345", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033825", "l": "oligosaccharide 4-alpha-D-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218806", "l": "FYN autophosphorylates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380780", "l": "Activation of Src (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229194", "l": "Depolymerization of lamin filaments after PKC-mediated phosphorylation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139917", "l": "tBID activates BAX protein (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375384", "l": "Bombesin-like receptors bind bombesin homologues (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10683", "l": "L-proline <=> D-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71825", "l": "G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58489", "l": "4-(trimethylamino)butanoate + H(+) + NADH + O2 => H2O + NAD(+) + succinate semialdehyde + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044688", "l": "7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420243", "l": "GHRH receptor binds GHRH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2399913", "l": "atRAL binds to RBP2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20890", "l": "3-hydroxy-2-methylpropanoate + CoA + H(+) => 3-hydroxy-2-methylpropanoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63003", "l": "(11Z,14Z,17Z)-eicosatrienamide + H2O <=> (11Z,14Z,17Z)-eicosatrienoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37678", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110498", "l": "DTOR is positively regulated by DRheb-GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52008", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA = 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44742", "l": "H(+) + rifamycin SV + S-adenosyl-L-homocysteine => 27-O-demethylrifamycin SV + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008928", "l": "IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3215295", "l": "USP7 deubiquitinates MDM2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55795", "l": "butan-2-one + H(+) + NADH + O2 <=> 1-hydroxy-2-butanone + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28273", "l": "acetyl-CoA + spermidine <=> CoA + H(+) + N(8)-acetylspermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202709", "l": "JAM2 dimerises (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16314", "l": "5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O => 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31091", "l": "acetyl-CoA + dodecanoyl-CoA = 3-oxotetradecanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29067", "l": "formate + H(+) + menaquinone-8 = CO2 + menaquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61934", "l": "(S)-miconazole(out) + ADP + H(+) + phosphate => (S)-miconazole(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64285", "l": "2-phenylethylamine + pyruvate => 2-phenylacetaldehyde + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63308", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 11-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102159", "l": "baicalein 7-O-glucuronosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853496", "l": "SCF:FBXL7 binds AURKA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22550", "l": "(S)-2-amino-6-oxohexanoate + H2O2 + NH4(+) => H2O + L-lysine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213236", "l": "TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25496", "l": "(2E)-geranyl diphosphate = (1S,5S)-beta-pinene + diphosphate"}, {"i": "EC:4.2.3.120", "l": "\"(-)-beta-pinene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "60.509711171324611", "identifiers": [{"i": "GO:0016830", "l": "carbon-carbon lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10471", "l": "D-xylulose 5-phosphate + phosphate <=> acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687585", "l": "Defective SLC34A2 does not cotransport HPO4(2-), 3Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788999", "l": "HV1-mediated H+ transfer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928594", "l": "SFKs phosphorylate GIT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64266", "l": "atrochrysone + CO2 => atrochrysone carboxylate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39119", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2 = (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62618", "l": "a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+) => a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791137", "l": "Expression of Talin-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210289", "l": "Recruitment of SYK to p-DAP12 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791134", "l": "Expression of SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54441", "l": "a (4S)-2,3-dehydroflavan-3,4-diol + H(+) => a 4-H-anthocyanidin with a 3-hydroxy group + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032054", "l": "LXA4/B4 translocate from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3229181", "l": "CALM1:Ca2+ binds CNG channel (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68603", "l": "ORC5 binds ORC2:ORC3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029680", "l": "Caspase-7 translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374667", "l": "DCC interaction with SIAH2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016807", "l": "cysteine-type carboxypeptidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030354", "l": "melanin-concentrating hormone activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371582", "l": "HSBP1 binds HSF1 trimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3318415", "l": "ATF2 acetylates histone H2B, H4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.54", "l": "\"Gamma-renin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2327746", "l": "FN1 aggregation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603719", "l": "Protein tyrosine phosphatases dephosphorylate NTRK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25602", "l": "4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O => 2-(2-methylsulfanyl)ethylmalate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.78", "l": "\"Granzyme A\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15004", "l": "keto-L-sorbose + NADP(+) <=> 5-dehydro-D-fructose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390459", "l": "Exchange of ADP for ATP in CCT/TriC:actin complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34367", "l": "acrylamide + H2O = acrylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3076905", "l": "Extracellular BTD hydrolyses BCTN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15350", "l": "L-glutamate + N(2)-acetyl-L-ornithine => L-ornithine + N-acetyl-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102991", "l": "myristoyl-CoA hydrolase activity"}, {"i": "RHEA:40119", "l": "H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22468", "l": "GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate"}, {"i": "EC:3.5.4.29", "l": "\"GTP cyclohydrolase IIa\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26045", "l": "CoA + N-acetyl-9-O-acetylneuraminate => acetyl-CoA + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15766", "l": "adenosylcob(III)inamide + GTP => adenosylcob(III)inamide phosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050034", "l": "L-rhamnose 1-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660530", "l": "Expression of SNCB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32551", "l": "(2E)-geranyl diphosphate + H2O = (S)-alpha-terpineol + diphosphate"}, {"i": "EC:4.2.3.111", "l": "\"(-)-alpha-terpineol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61428", "l": "cis-trans-nepetalactol + NAD(+) = cis-trans-nepetalactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43189", "l": "S-adenosyl-L-methionine + uridine(2634) in 25S rRNA => H(+) + N(3)-methyluridine(2634) in 25S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50110", "l": "CoA + H(+) + N-hexadecanoyl-taurine => hexadecanoyl-CoA + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51896", "l": "H2O + N(1)-acetylspermine = acetate + spermine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-112396", "l": "Separation of elongating transcript from template (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39834", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoate + O2 <=> 2-hydroxyhexadecanoate + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333051", "l": "RPA1 binds HSF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38026", "l": "gamma-tocotrienol <=> 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606602", "l": "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110360", "l": "Recruitment of POLB to the AP site (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.41", "l": "\"Complement subcomponent C1r\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419452", "l": "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047252", "l": "beta-mannosylphosphodecaprenol-mannooligosaccharide 6-mannosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604969", "l": "Active FLT3 binds PTPN11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13751", "l": "a ribonucleoside 5'-diphosphate + ADP => a ribonucleoside 5'-triphosphate + AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357432", "l": "AXL binds SRC-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050248", "l": "Renilla-luciferin 2-monooxygenase activity"}, {"i": "RHEA:14765", "l": "coelenterazine h + O2 = CO2 + excited coelenteramide h monoanion + H(+) + hnu"}, {"i": "EC:1.13.12.5", "l": "\"Renilla-type luciferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51139", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 2 O2 <=> (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020513", "l": "GRIN2B gene expression is inhibited by MECP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005469", "l": "succinate:fumarate antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51127", "l": "uridine in snRNA <=> pseudouridine in snRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30607", "l": "A + all-trans-phytofluene = AH2 + all-trans-zeta-carotene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44725", "l": "2,3-saturated fatty aldehyde + NADP(+) => (2E)-fatty aldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26444", "l": "a ubiquinol + acetaldehyde => a ubiquinone + ethanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59550", "l": "H2O2 + N,N',N''-triacetylchitotriono-1,5-lactone => N,N',N''-triacetylchitotriose + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66649", "l": "(2E,6E)-farnesyl diphosphate => african-3-ene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664275", "l": "Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4647593", "l": "EP400 binds CDKN1A promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1470010", "l": "Dimerization of STATs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45815", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA <=> a very-long-chain (2E)-enoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17118", "l": "ATP + L-glutamate + methylamine => ADP + H(+) + N(5)-methyl-L-glutamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25078", "l": "(2S)-2-isopropyl-3-oxosuccinate + H(+) = 4-methyl-2-oxopentanoate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24772", "l": "7(1)-hydroxychlorophyllide a + NADP(+) = chlorophyllide b + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40745", "l": "(20S)-ginsenoside C-K + 2 D-glucose => (20S)-ginsenoside Rd + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785607", "l": "FANCM binds FAAP24 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-164840", "l": "ADP and Pi bind to ATPase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944254", "l": "Association of procollagen type XXVI (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3791319", "l": "NID1 degradation by MMP19 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167113", "l": "Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60281", "l": "L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805399", "l": "TAF1 phosphorylates TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43730", "l": "H(+) + H2O + juvenile hormone III + oxidized [NADPH--hemoprotein reductase] => methyl (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31490", "l": "soyasapogenol B 3-O-beta-D-glucuronate + UDP-alpha-D-galactose <=> H(+) + soyasaponin III + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2201316", "l": "Activated TLR2/4 interacts with MAL (TIRAP) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610752", "l": "GLI3R translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60428", "l": "(indol-3-yl)acetyl-L-aspartate + H2O = (indol-3-yl)acetate + L-aspartate"}, {"i": "EC:3.5.1.134", "l": "\"(Indol-3-yl)acetyl-L-aspartate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399930", "l": "Activation of PAK by Rac1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11460", "l": "ADP + D-glucose = AMP + D-glucose 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15076", "l": "3-D-glucuronosyl-N(2),6-disulfo-beta-D-glucosamine + H2O <=> D-glucuronate + N(2),6-disulfo-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59172", "l": "hexadecanoyl-AMP + holo-[(hydroxy)phthioceranic acid synthase] = AMP + H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814088", "l": "SYS1 binds AcM-ARFRP1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25250", "l": "H(+) + 2 pyruvate => (2S)-2-acetolactate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56797", "l": "[corrinoid adenosyltransferase]-cob(I)alamin + ATP => adenosylcob(III)alamin + apo-[corrinoid adenosyltransferase] + triphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080132", "l": "fatty acid alpha-hydroxylase activity"}, {"i": "REACT:R-HSA-5693761", "l": "FA2H hydroxylates CERA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20002", "l": "glycolaldehyde + H2O + NAD(+) => glycolate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090711", "l": "FMN hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41840", "l": "3-oxooctanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyoctanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698008", "l": "FLT3 mutants:GRB2:p-Y-GAB2 binds PTPN11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429732", "l": "multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430183", "l": "NCK binds PAK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50508", "l": "acetyl-CoA + N-terminal L-valyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16014", "l": "ATP + glycine + tRNA(Gly) => AMP + diphosphate + glycyl-tRNA(Gly)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31771", "l": "an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+)"}, {"i": "RHEA:31775", "l": "all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + H(+) + hexadecanoate"}, {"i": "EC:3.1.1.64", "l": "\"Retinoid isomerohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9674529", "l": "AAMP binds to TBXA2R (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5669158", "l": "NF2 binds PAK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31500", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose => a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624953", "l": "ARL13B binds INPP5E (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682983", "l": "ATM phosphorylates WHSC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39809", "l": "octadecanoate(out) => octadecanoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22524", "l": "2 A + a carotenoid beta-end derivative = a carotenoid phi-end derivative + 2 AH2"}, {"i": "EC:1.3.99.39", "l": "\"Carotenoid phi-ring synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48210", "l": "(2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + nonanoyl-CoA + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37497", "l": "1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53353", "l": "5,6-dihydrouridine(20b) in tRNA + NAD(+) => H(+) + NADH + uridine(20b) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32796", "l": "ATP + H2O + L-cysteine(out) => ADP + H(+) + L-cysteine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66115", "l": "2-oxobutanoate + L-tyrosine <=> (2S)-2-aminobutanoate + 3-(4-hydroxyphenyl)pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14111", "l": "1-pyrroline-5-carboxylate + 2 H(+) + NADPH => L-proline + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46695", "l": "4-hydroxybenzoate + ATP + H(+) <=> 4-hydroxybenzoyl-5'-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13346", "l": "(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] => diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005278", "l": "acetylcholine:proton antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392195", "l": "Gi activation by P2Y purinoceptor 12 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12551", "l": "2-cis,4-trans-xanthoxin + NAD(+) <=> 2-cis-(+)-abscisic aldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38115", "l": "(9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol = 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5679205", "l": "ULK1 phosphorylates Beclin-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54324", "l": "a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 8 oxidized 2[4Fe-4S]-[ferredoxin] = a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54775", "l": "ATP + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide <=> 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22510", "l": "diphosphate + DNA(n+1) => a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428625", "l": "Vesicular inhibitory amino acid transport (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029456", "l": "RAC1 and CDC42 activate PAK1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0030296", "l": "protein tyrosine kinase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801109", "l": "CHM binds RGGT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198731", "l": "ERK1/2 activates ELK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140217", "l": "Transactivation of PMAIP1 (NOXA) by E2F1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47640", "l": "adenosine(1785)/adenosine(1786) in 18S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1785)/N(6)-dimethyladenosine(1786) in 18S rRNA + 4 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693148", "l": "BCKDK phosphorylates BCKDH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42837", "l": "acetyl-CoA + 7 H(+) + 5 malonyl-CoA + 3 NADPH => 5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 4 H2O + 3 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050040", "l": "lactate 2-monooxygenase activity"}, {"i": "MetaCyc:LACTATE-2-MONOOXYGENASE-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052886", "l": "9,9'-dicis-carotene:quinone oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008764", "l": "UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"}, {"i": "RHEA:16429", "l": "ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate"}, {"i": "EC:6.3.2.9", "l": "\"UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249386", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55514", "l": "11-hydroxycucurbitadienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48859", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 <=> (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57120", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371422", "l": "ATP hydrolysis by HSP70 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785722", "l": "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50874", "l": "(5,6,15R)-trihydroxy-(7E,9E,11Z,13E,17Z)-eicosapentaenoate => (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34891", "l": "selenite(in) = selenite(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11500", "l": "3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O = 3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate"}, {"i": "EC:3.1.3.45", "l": "\"3-deoxy-manno-octulosonate-8-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42812", "l": "cholesterol + octadecanoyl-CoA = cholesteryl octadecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.15"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55728", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] = 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59734", "l": "AMP + 2 H(+) + N(6)-biotinyl-L-lysyl-[protein] => biotinyl-5'-AMP + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52810", "l": "H(+) + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine => adenosine in U6 snRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944263", "l": "Association of procollagen type II (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47579", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) <=> CMP + ganglioside GD1c (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.6.2.13", "l": "\"ABC-type autoinducer-2 transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21801", "l": "all-trans-antheraxanthin + L-ascorbate => all-trans-zeaxanthin + H2O + L-dehydroascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626034", "l": "EEF1A1 dissociates from p-GFAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41264", "l": "NAD(+) + prostaglandin A1 => 15-keto-prostaglandin A1 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168921", "l": "TRIF:activated TLR3/TLR4 complex recruits RIP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64724", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S,14S)-dihydroperoxy-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37992", "l": "delta-tocopherol + S-adenosyl-L-methionine => beta-tocopherol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-390329", "l": "Dephosphorylation of AKT by PP2A (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11525", "l": "5beta-cholestan-3-one + NADP(+) => cholest-4-en-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853800", "l": "ARTN binds RET:GFRA1,GFRA3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050656", "l": "3'-phosphoadenosine 5'-phosphosulfate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21989", "l": "malonyl-CoA + pelargonidin 3-O-(6-O-[(E)-caffeoyl]-beta-D-glucoside) 5-O-beta-D-glucoside => 4'''-demalonylsalvianin + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53222", "l": "6beta,16alpha,17alpha-trihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 16alpha,17alpha-dihydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19914", "l": "a (3R)-hydroxyacyl-[ACP] + NAD(+) => a 3-oxoacyl-[ACP] + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66902", "l": "CO2 + 2 CoA + cyclo-acetoacetyl-L-tryptophan + H2O => acetyl-CoA + L-tryptophan + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64997", "l": "ATP + H(+) + octanoate => diphosphate + octanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25011", "l": "H(+) + H2O + N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036403", "l": "arachidonate 8(S)-lipoxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47295", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.21", "l": "\"Glutamate carboxypeptidase II\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944261", "l": "Association of procollagen type XIII (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296233", "l": "T2Rs bind bitter-tasting compounds (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909720", "l": "IFN alpha/beta binds to IFNAR2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694441", "l": "CSNK1D phosphorylates SEC23 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35302", "l": "3-hydroxyoctadecanoyl-CoA + NADP(+) <=> 3-oxooctadecanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60025", "l": "(R,R)-chrysanthemyl diphosphate + H2O => (R,R)-chrysanthemol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638006", "l": "ARL3 hydrolyzes GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33722", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-hexacosanoylsphinganine <=> a 1,2-diacyl-sn-glycerol + N-(hexacosanoyl)-sphinganine-1-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49883", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015092", "l": "high-affinity ferric iron transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18788", "l": "A + gibberellin A12 aldehyde + H2O <=> AH2 + gibberellin A12 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202604", "l": "Formation of a heteromeric BMP receptor complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805546", "l": "Keratin type I binds keratin type II (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52275", "l": "(1H-indol-3-yl)-N-methylmethanamine + S-adenosyl-L-methionine <=> gramine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1006143", "l": "CD46 binds C3b (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41733", "l": "[(1->4)-alpha-D-glucosyl](n) + phosphate => [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43062", "l": "beta-D-glucose 1-phosphate + glycerol => 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63334", "l": "beta-L-arabinose => alpha-L-arabinose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130151", "l": "Dimerization of DAP12 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12375", "l": "2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O <=> 4-oxohex-2-enedioate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.43", "l": "\"Atroxase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694277", "l": "nsp8 generates RNA primers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390641", "l": "ADRA1A,B,D bind ADR,NAd (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420688", "l": "GABAB heterodimeric receptor binds GABA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50011", "l": "6-methylpretetramide + 2 H(+) + NADPH + O2 <=> 4-hydroxy-6-methylpretetramide + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55466", "l": "11,20-dihydroxysugiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 11-hydroxysugiol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9663511", "l": "BIL binds GSTA1, FABP1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60933", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => 17-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53815", "l": "cholestanol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-26-hydroxycholestanol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2509838", "l": "ITPA hydrolyses dITP to dIMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17160", "l": "ATP + creatine <=> ADP + H(+) + N-phosphocreatine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429449", "l": "Syk activation leads to SLP-76 activation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48494", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703442", "l": "Phosphorylated FLT3 fusions bind GRB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938773", "l": "RNF144A polyubiquitinates PRKDC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20230", "l": "2,3-dihydroxybenzoate + ATP + H(+) => 2,3-dihydroxybenzoyl-5'-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047972", "l": "guanidinopropionase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42905", "l": "guanosine(748) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(748) in 23S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051371", "l": "muscle alpha-actinin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443779", "l": "Linkage of L1 with treadmilling F-actin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45664", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2529020", "l": "CK2 phosphorylates condensin I subunits (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19826", "l": "(2E,6E)-farnesyl diphosphate => (+)-aristolochene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29351", "l": "Zn(2+)(in) = Zn(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28859", "l": "Ag(+)(in) + H(+)(in) = Ag(+)(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18106", "l": "ATP + Ca(2+)(in) + H2O => ADP + Ca(2+)(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41105", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + H(+) => 1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985594", "l": "MYO9B inactivates RHOA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12383", "l": "L-2,4-diaminobutanoate + pyruvate <=> L-alanine + L-aspartate 4-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29169", "l": "acetate + CO2 + ubiquinol-8 => H2O + pyruvate + ubiquinone-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798004", "l": "TP53 stimulates BNIP3L expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24489", "l": "H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] => (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390909", "l": "HRH2 binds hist (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52116", "l": "15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110360", "l": "Recruitment of POLB to the AP site (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209903", "l": "Noradrenaline is converted to adrenaline (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27584", "l": "2-methyleneglutarate + H2O => 2-(hydroxymethyl)glutarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64731", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (7S,17S)-dihydroperoxy-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31548", "l": "2 (2E,6E)-farnesyl diphosphate => 15-cis-4,4'-diapophytoene + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56921", "l": "a medium chain fatty acid + ATP + H(+) => a medium-chain fatty acyl-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696183", "l": "AOC3 deaminates BZAM (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54231", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine <=> 2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051448", "l": "gonadotropin-releasing hormone binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77589", "l": "Recognition of AAUAAA sequence by CPSF (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13470", "l": "A + H2O + thymine => 5-methylbarbiturate + AH2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380294", "l": "Loss of C-Nap-1 from centrosomes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23590", "l": "oxalyl-CoA + succinate => oxalate + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26204", "l": "ammeline + H(+) + H2O <=> ammelide + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39494", "l": "(2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH <=> (11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450488", "l": "BRF1 Complex recruits RNA degradation activities (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47077", "l": "17beta-hydroxyandrosta-1,4-dien-3-one + H(+) + NADPH => 17beta-hydroxy-5beta-androst-1-en-3-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.185"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033918", "l": "kappa-carrageenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65788", "l": "diuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-(3,4-dichlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047575", "l": "4-carboxymuconolactone decarboxylase activity"}, {"i": "RHEA:23348", "l": "(R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+) = (4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2"}, {"i": "EC:4.1.1.44", "l": "\"4-carboxymuconolactone decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61218", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1170539", "l": "Prolactin receptor is internalized (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1470010", "l": "Dimerization of STATs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391942", "l": "IP receptor can bind prostacyclin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848873", "l": "PTK6 phosphorylates ARAP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.33"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21966", "l": "a carboxylate + choline + H(+) => an acylcholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12978", "l": "H2O + N-phosphocreatine => creatine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18272", "l": "ethyl (S)-3-hydroxyhexanoate + NADP(+) <=> ethyl 3-oxohexanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035100", "l": "ecdysone binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047173", "l": "phosphatidylcholine-retinol O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12412", "l": "(2R)-3-phosphoglycerate + H2O = (R)-glycerate + phosphate"}, {"i": "EC:3.1.3.38", "l": "\"3-phosphoglycerate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2400001", "l": "AKT1 E17K mutant phosphorylates CHUK (IKKalpha) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606583", "l": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34521", "l": "[alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + 3 H(+) + 3 UDP => N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + 3 UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102923", "l": "3'-N-debenzoyl-2'-deoxytaxol N-benzoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103081", "l": "methylthiopropylmalate dehydrogenase activity"}, {"i": "MetaCyc:RXNQT-4165"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047876", "l": "endoglycosylceramidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15669", "l": "5'-dephospho-(DNA) + ATP = ADP + H(+) + phospho-5'-(DNA)"}, {"i": "RHEA:54580", "l": "5'-dephospho-(RNA) + ATP = 5'-end-(RNA) + ADP + H(+)"}, {"i": "EC:2.7.1.78", "l": "\"Polynucleotide 5'-hydroxyl-kinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019170", "l": "methylglyoxal reductase (NADH-dependent) activity"}, {"i": "RHEA:24528", "l": "(R)-lactaldehyde + NAD(+) = H(+) + methylglyoxal + NADH"}, {"i": "EC:1.1.1.78", "l": "\"Methylglyoxal reductase (NADH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25774", "l": "(2S,3S)-3-hydroxyasparagine + CO2 + succinate => 2-oxoglutarate + L-asparagine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50593", "l": "13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) => 15-oxoprostaglandin F1alpha + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686930", "l": "RIPK3 is cleaved by CASP8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "52.731944790800767", "identifiers": [{"i": "GO:0016829", "l": "lyase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033933", "l": "branched-dextran exo-1,2-alpha-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174660", "l": "nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12607", "l": "1-deoxy-D-xylulose 5-phosphate + CO2 => D-glyceraldehyde 3-phosphate + H(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29749", "l": "3-phenylpropanoate(out) => 3-phenylpropanoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.20", "l": "\"Penicillopepsin\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047882", "l": "estradiol 6-beta-monooxygenase activity"}, {"i": "RHEA:19137", "l": "17beta-estradiol + AH2 + O2 = 6beta-hydroxyestradiol-17beta + A + H2O"}, {"i": "EC:1.14.99.11", "l": "\"Estradiol 6-beta-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656459", "l": "Defective KHK does not phosphorylate beta-D-fructose (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875591", "l": "DOCK7 activates RAC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912415", "l": "NOTCH3 gene transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-433711", "l": "Cis-homodimerization of nectins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36124", "l": "gibberellin A20 + S-adenosyl-L-methionine => gibberellin A20 methyl ester + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25318", "l": "2-oxoglutarate + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate <=> L-2-acetamido-6-oxoheptanedioate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64541", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52710", "l": "D-ribose 5-phosphate + guanine => GMP + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102689", "l": "UDP-glucose:isopentenyladenine 7-N-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-4727"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620915", "l": "BTG1 gene expression is stimulated by FOXO3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199299", "l": "AKT phosphorylates FOXO transcription factors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46005", "l": "2-methylpropanal + CoA + NAD(+) => 2-methylpropanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23680", "l": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H(+) + phosphate"}, {"i": "EC:3.6.1.15", "l": "\"Nucleoside-triphosphate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5634228", "l": "TRAF1 is cleaved by caspases (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64000", "l": "(4R)-hydroxysphinganine + octadecanoyl-CoA = CoA + H(+) + N-octadecanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849857", "l": "KLK5 cleaves and activates CELA2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29631", "l": "alpha-maltotetraose + H2O = alpha-D-glucose + alpha-maltotriose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36494", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA <=> (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609917", "l": "Tail-anchored protein:ASNA1:ADP:WRB:CAMLG dissociates yielding Tail-anchored protein in the endoplasmic reticulum membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18796", "l": "alpha-D-ribose 1-phosphate <=> D-ribose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17158", "l": "ATP + creatine => ADP + H(+) + N-phosphocreatine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25549", "l": "(+)-copalyl diphosphate => abieta-8(14),12-diene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035605", "l": "peptidyl-cysteine S-nitrosylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63764", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061651", "l": "Atg12 conjugating enzyme activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382096", "l": "Formation of NR-NCOR Corepressor Complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12972", "l": "a sn-glycero-3-phosphoester + H2O <=> an alcohol + H(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17950", "l": "3-hydroxy-1H-quinolin-4-one + O2 => CO + H(+) + N-formylanthranilate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51131", "l": "A + an aliphatic amine + H2O <=> AH2 + an aldehyde + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647994", "l": "RAS proteins are depalmitoylated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61388", "l": "ATP + biotin(in) + H2O = ADP + biotin(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450550", "l": "PKCalpha phosphorylates HuR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061609", "l": "fructose-1-phosphate aldolase activity"}, {"i": "RHEA:30851", "l": "beta-D-fructose 1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2214351", "l": "PLK1 phosphorylates GORASP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44308", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine = 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013143", "l": "RAC1 GEFs activate RAC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74258", "l": "XDH oxidizes xanthine to form urate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12989", "l": "dolichyl beta-D-mannosyl phosphate + H2O = D-mannose + dolichyl phosphate + H(+)"}, {"i": "EC:3.1.4.49", "l": "\"Dolichylphosphate-mannose phosphodiesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2750181", "l": "Syndecan-2 binds CASK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11999", "l": "biphenyl-2-ol + H(+) + NADH + O2 <=> biphenyl-2,3-diol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0004738", "l": "pyruvate dehydrogenase activity"}, {"i": "REACT:R-HSA-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47619", "l": "ethionamide + H(+) + NADPH + O2 <=> ethionamide S-oxide + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53305", "l": "AH2 + 2 ATP + 2 cob(II)alamin => A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010179", "l": "IAA-Ala conjugate hydrolase activity"}, {"i": "MetaCyc:RXN-2981"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13773", "l": "(S)-cheilanthifoline + O2 + reduced [NADPH--hemoprotein reductase] = (S)-stylopine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.19.64", "l": "\"(S)-stylopine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25808", "l": "H2O + O2 + spermidine = 3-aminopropanal + H2O2 + putrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19356", "l": "glycocholate + H2O <=> cholate + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43539", "l": "2 D-glyceraldehyde 3-phosphate <=> 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222644", "l": "TrxA/B1 reactivates Tpx (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59148", "l": "ATP + CoA + marinolate C = AMP + diphosphate + marinoloyl-CoA C"}, {"i": "RHEA:59152", "l": "ATP + CoA + pseudomonate C = AMP + diphosphate + pseudomonoyl-CoA C"}, {"i": "EC:6.2.1.60", "l": "\"Marinolic acid--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17572", "l": "(R)-reticuline + NADP(+) <=> 1,2-dehydroreticuline + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63960", "l": "abscisate(out) + ATP + H2O = abscisate(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374680", "l": "L1 trans-homophilic interaction (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624952", "l": "Assembly of the retrograde IFT train (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14070", "l": "D-fructose + NADP(+) => 5-dehydro-D-fructose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042970", "l": "homoserine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11184", "l": "3-(carbamoylamino)propanoate + 2 H(+) + H2O = beta-alanine + CO2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626227", "l": "CP110 and CEP97 dissociate from the centriole (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610718", "l": "CK1 phosphorylates p-GLI2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202510", "l": "Activation of TAK1-TAB2 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964619", "l": "PAK1 binds ARHGEF6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950415", "l": "Expression of heterogeneous nuclear ribonucleoprotein F (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64833", "l": "3-hydroxybenzyl alcohol + benzoyl-CoA => 3-hydroxy-benzyl benzoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47406", "l": "3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH => (24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42166", "l": "(5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O => (11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689861", "l": "Recruitment of XPA and release of CAK  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029460", "l": "PAK1 phosphorylates LIMK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2032770", "l": "Translocation of YAP1 to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617535", "l": "Activated calmodulin binds ADCY1,ADCY8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570573", "l": "Defective RFT1 does not flip the N-glycan precursor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538891", "l": "CLK:CYC heterodimer dissociates from per, tim, vri, and Pdp1 genes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395517", "l": "NADPH transfers electrons to FDXR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804741", "l": "MDM2 forms homo- or heterodimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-990489", "l": "Kinesin-13 is a dimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53334", "l": "2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102728", "l": "campest-4-en-3-one,NADPH:steroid 5alpha-reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419428", "l": "S1PR2-5 bind S1P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0016622", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor"}, {"i": "EC:1.2.2.-", "l": "\"With a cytochrome as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40599", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = a 2-acyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32370", "l": "4 [Fe(III)cytochrome c] + L-galactono-1,4-lactone <=> 4 [Fe(II)cytochrome c] + 5 H(+) + L-dehydroascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33980", "l": "DIBOA beta-D-glucoside + H2O => D-glucose + DIBOA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16299", "l": "17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH => 5alpha-androstane-3beta,17beta-diol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429441", "l": "SYK activation by SRC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61152", "l": "(E)-caffeoyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] = CoA + myricetin 3-O-[(6-O-(E)-caffeoyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37205", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28753", "l": "dihydroxyacetone phosphate + ubiquinol-8 => sn-glycerol 3-phosphate + ubiquinone-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23158", "l": "(indol-3-yl)acetonitrile + H2O => (E)-(indol-3-yl)acetaldehyde oxime"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050165", "l": "pantetheine kinase activity"}, {"i": "MetaCyc:PANTETHEINE-KINASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191636", "l": "Phosphorylation of Cx43 by c-src (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5226999", "l": "ADD1:ADD3 binds DMTN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186765", "l": "PLC-gamma binds to the active receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944214", "l": "Association of procollagen type I (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25351", "l": "H2O + L-cysteinyl-tRNA(Pro) = H(+) + L-cysteine + tRNA(Pro)"}, {"i": "EC:3.6.1.n2", "l": "\"L-cysteinyl-tRNA(Pro)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.2.-", "l": "\"Peptidyl-amino-acid hydrolases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45634", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24040", "l": "NADPH + 2 oxidized [cytochrome P450] = H(+) + NADP(+) + 2 reduced [cytochrome P450]"}, {"i": "EC:1.6.2.4", "l": "\"NADPH--hemoprotein reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42056", "l": "13-cis-retinol + NAD(+) = 13-cis-retinal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080102", "l": "3-methylthiopropyl glucosinolate S-oxygenase activity"}, {"i": "MetaCyc:RXN-2221"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55180", "l": "2-oxoglutarate + 3-methylnonanoyl-CoA + O2 = 2-hydroxy-3-methylnonanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26033", "l": "3,3'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202331", "l": "Recruitment of PLC-gamma1 to SLP-76 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39273", "l": "(2E,15Z)-tetracosadienoyl-CoA + H2O => (3R)-hydroxy-(15Z)-tetracosenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39003", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42819", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol <=> cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2529020", "l": "CK2 phosphorylates condensin I subunits (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36000", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15629", "l": "a steroid + 2 H(+) + O2 + 2 reduced [adrenodoxin] = an 11beta-hydroxysteroid + H2O + 2 oxidized [adrenodoxin]"}, {"i": "EC:1.14.15.4", "l": "\"Steroid 11-beta-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17579", "l": "ADP-L-glycero-beta-D-manno-heptose => ADP-D-glycero-beta-D-manno-heptose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698021", "l": "PTPN11:p-STAT5 binds BCL2L1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20125", "l": "H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0005186", "l": "pheromone activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002058", "l": "uracil binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38337", "l": "(20S)-ginsenoside Rg3 + 2 D-glucose => (20S)-ginsenoside Rb1 + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428990", "l": "Arachidonate diffuses across the ER membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209792", "l": "N-acetylation of serotonin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007465", "l": "UXT gene expression is repressed by the PRC1L4 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29503", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + patchoulol"}, {"i": "EC:4.2.3.70", "l": "\"Patchoulol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604247", "l": "JAG1 binds NOTCH4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2534240", "l": "HSPG2 (perlecan) degradation by MMP14, MMP15 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31770", "l": "2-oxoglutarate + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine <=> L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008914", "l": "leucyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655443", "l": "PXKLP-K305-CSAD decarboxylates 3-sulfinoalanine to hypotaurine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088322", "l": "Defective GNE does not phosphorylate ManNAc to ManNAc-6-P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49315", "l": "2-trans,4-trans-xanthoxin + NAD(+) <=> 2-trans-(+)-abscisic aldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.103"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.-.-", "l": "\"Acting on the aldehyde or oxo group of donors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429767", "l": "Passive I- efflux mediated by SMCT1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004328", "l": "formamidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130731", "l": "Formation of COPII vesicle (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41637", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + H2O => 1-O-(1Z-alkenyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58172", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = beta-pinacene + diphosphate"}, {"i": "EC:4.2.3.200", "l": "\"Beta-pinacene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.42", "l": "\"Kdo(2)-lipid A phosphoethanolamine 7''-transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647994", "l": "RAS proteins are depalmitoylated (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43057", "l": "5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH => 10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62894", "l": "6 CO2 + 7 CoA + 2 H2O + nor-toralactone => acetyl-CoA + 6 H(+) + 6 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31165", "l": "(2E)-hexadecenoyl-CoA + H2O => (3S)-hydroxyhexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9619376", "l": "CAMK1 binds calmodulin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36654", "l": "8-desmethylnovobiocic acid + S-adenosyl-L-methionine <=> H(+) + novobiocic acid + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5336443", "l": "LIN7, CASK and APBA1 bind (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54646", "l": "(S)-1-pyrroline-5-carboxylate + H(+) + H2O => trans-4-hydroxy-L-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730899", "l": "Oligomerization of BCL10 and MALT1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211716", "l": "Rho GTPase-activating protein 10 (RHG10) interacts with caspase-activated PAK-2p34 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50345", "l": "3 (S)-methylmalonyl-CoA + a long-chain fatty acyl-CoA + 9 H(+) + holo-[mycolipanoate synthase] + 6 NADPH => 3 CO2 + 4 CoA + 3 H2O + long-chain mycolipanoyl-[mycolipanoate synthase] + 6 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5444523", "l": "Formation of MSH1:PMS2 Complex (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388808", "l": "CD28 homodimer binds B7-2 monomer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35874", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3782655", "l": "HDAC10 deacetylates histone (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50884", "l": "(9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O = (9Z-octadecenoyl)-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9630923", "l": "NFkB inhibitor binds NFkB complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48781", "l": "ATP + L-erythrulose => ADP + H(+) + L-erythrulose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198440", "l": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016984", "l": "ribulose-bisphosphate carboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59154", "l": "AMP + diphosphate + pseudomonoyl-CoA C => ATP + CoA + pseudomonate C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210290", "l": "Interaction of PECAM-1 and SHIP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27841", "l": "9H-carbazole + H(+) + NADH + O2 <=> 2'-aminobiphenyl-2,3-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236972", "l": "Escape of antigens from phagosome to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111966", "l": "GRK2 binds CALM1:4Ca2+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1362465", "l": "GHBP binds GHR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60426", "l": "diphosphate + valerianol => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17589", "l": "2,2'-iminodipropanoate + H2O + NAD(+) = H(+) + L-alanine + NADH + pyruvate"}, {"i": "EC:1.5.1.17", "l": "\"Alanopine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22519", "l": "ATP + taurocyamine <=> ADP + H(+) + N-phosphotaurocyamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855195", "l": "I(1,3,4,5,6)P5 transports from the cytosol to the ER lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23978", "l": "(RNA)-3'-(2',3'-cyclophosphooxy)-ribonucleotide + AMP + diphosphate => (RNA)-3'-(3'-phosphooxy-ribonucleotide) + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75172", "l": "Formation of RAD50:MRE11 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41393", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938815", "l": "RNF152 polyubiquitinates RRAGA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937134", "l": "miR-27a binds RUNX1 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351456", "l": "Association of gamma H2AX and NBS1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.24.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14738", "l": "CTP => 3',5'-cyclic CMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669250", "l": "PAK1 phosphorylates FLNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706319", "l": "Active FLT3 binds to SLA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55834", "l": "6beta-hydroxycortisone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cortisone + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48323", "l": "ganglioside GA1 + GDP-beta-L-fucose <=> ganglioside Fuc-GA1 + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46392", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 4beta,24S-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55311", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28843", "l": "choline(in) + H(+)(in) = choline(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421179", "l": "inosine 5'-monophosphate (IMP) + H2O => inosine + orthophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036729", "l": "Defective GAA does not hydrolyze lysosomal glycogen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113402", "l": "Formation of DSIF:NELF:early elongation complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19221", "l": "2 formaldehyde + H2O = formate + H(+) + methanol"}, {"i": "EC:1.2.98.1", "l": "\"Formaldehyde dismutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65573", "l": "(-)-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] => (-)-4'-desmethyl-deoxypodophyllotoxin + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67125", "l": "a hydroperoxide + L-cysteinyl-[protein] => an alcohol + S-hydroxy-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34777", "l": "a 3-oxosteroid + CO2 + NADH => a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159826", "l": "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691167", "l": "CUL1, SKP1, FBXL5 bind (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37173", "l": "1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9674529", "l": "AAMP binds to TBXA2R (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55393", "l": "adenosine in mRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine in mRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350598", "l": "Arginine<=>Agmatine+CO2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40472", "l": "(2S)-methylpentadecanoyl-CoA + O2 => 2-methyl-(2E)-pentadecenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72635", "l": "eIF4F binds to mRNP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55149", "l": "a [(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP(+) => a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382055", "l": "Grb7 binds to the active PDGF receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15185", "l": "L-arginine + succinyl-CoA = CoA + H(+) + N(2)-succinyl-L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601883", "l": "Complexed PIWIL4 binds cleaved transposon RNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16486", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazole-4-acetate => 1-(5-phosphoribosyl)imidazole-4-acetate + ADP + diphosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47069", "l": "4alpha-formyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 => 4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51525", "l": "(S)-corytuberine + S-adenosyl-L-methionine => magnoflorine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58475", "l": "2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + O2 <=> CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36190", "l": "1-O-alkyl-2-acyl-sn-glycerol + CDP-ethanolamine <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38309", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379861", "l": "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62827", "l": "beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + GDP-beta-L-fucose <=> beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosamine + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848596", "l": "PTK6 binds PXN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23402", "l": "5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+) => 7,8-dihydroxykynurenate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65618", "l": "25-hydroxycholest-4-en-3-one + AH2 => A + cholest-4-en-3-one + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20562", "l": "3-hydroxypyruvate + H(+) => CO2 + glycolaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64129", "l": "H2O + N-octadecanoyl-L-phenylalanine => L-phenylalanine + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13889", "l": "FAD + H2O = AMP + FMN + 2 H(+)"}, {"i": "EC:3.6.1.18", "l": "\"FAD diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12557", "l": "6-phospho-D-glucono-1,5-lactone + H2O => 6-phospho-D-gluconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427570", "l": "Group 3 - Selective Cl- transport (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23669", "l": "apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin => AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650722", "l": "Translation of DDIT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28436", "l": "((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP] => (9Z)-hexadecenoyl-(Kdo)2-lipid IVA + tetradecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9656244", "l": "DRD2 binds DA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47346", "l": "(25R)-3beta,26-dihydroxycholest-5-en-7-one + H2O + 2 oxidized [adrenodoxin] => 3beta-hydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65327", "l": "acetyl-CoA + chrodrimanin A <=> chrodrimanin B + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013109", "l": "RHOC GEFs activate RHOC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956050", "l": "NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167115", "l": "Addition of nucleotides between position +11 and +30 on HIV-1 transcript (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58694", "l": "FADH2 + H2O + NAD(+) + rifamycin SV hemiaminal => FADH2-C4alpha-hydroperoxide + H(+) + NADH + rifamycin SV"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31676", "l": "NADP(+) + raucaffrinoline => H(+) + NADPH + perakine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52881", "l": "16beta,17beta-estriol + UDP-alpha-D-glucuronate => 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944232", "l": "Association of procollagen type XII (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55051", "l": "(3E,5Z)-dodecadienoyl-CoA + H2O <=> (3E,5Z)-dodecadienoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67113", "l": "L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11659", "l": "ATP + holo-[peptidyl-carrier protein] + L-proline <=> AMP + diphosphate + L-prolyl-[peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18013", "l": "H2O + N(5)-ethyl-L-glutamine = ethylamine + L-glutamate"}, {"i": "EC:3.5.1.65", "l": "\"Theanine hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64457", "l": "L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60972", "l": "hexan-1-ol + NAD(+) = H(+) + hexanal + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9637605", "l": "PstS1 binds MRC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41648", "l": "aniline + ATP + L-glutamate = ADP + N(5)-phenyl-L-glutamine + phosphate"}, {"i": "EC:6.3.1.18", "l": "\"Gamma-glutamylanilide synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372449", "l": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9634834", "l": "ACHEIs bind ACHE (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9687625", "l": "ATP binds MLKL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33501", "l": "3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2 => H(+) + prephenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3239014", "l": "MAPKAPK5 phosphorylates TP53 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34188", "l": "(2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O => (2Z)-2-hydroxypenta-2,4-dienoate + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46970", "l": "AH2 + isopentenyldehydrorhodopin => A + dihydroisopentenyldehydrorhodopin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63607", "l": "[Pyr1]apelin-13 + H2O <=> [Pyr1]apelin-12 + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130478", "l": "Interaction of invariant chain trimer and MHC II alpha beta dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13864", "l": "D-xylose + NAD(+) <=> D-xylono-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60221", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(4)-[histone H3] + O2 => CO2 + formaldehyde + L-lysyl(4)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798044", "l": "BTG2 binds CCR4-NOT complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65050", "l": "4-acetoxybenzaldehyde + H(+) + NADH => 4-acetoxybenzyl alcohol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864577", "l": "TFAP2C translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40933", "l": "(3S)-3-hydroxy-L-ornithine + CO2 + succinate => 2-oxoglutarate + L-ornithine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371353", "l": "Soluble TNF-alpha binds TNFR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21740", "l": "2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + H(+) + hydrogen sulfide + pyruvate"}, {"i": "EC:2.8.1.2", "l": "\"3-mercaptopyruvate sulfurtransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61319", "l": "germacra-1(10),4,11(13)-trien-12-al + O2 + reduced [NADPH--hemoprotein reductase] <=> germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46064", "l": "(11E)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (6Z,11E)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917839", "l": "apo-Transferrin dissociates from the receptor complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50168", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38836", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16354", "l": "2-oxoglutarate + taurine => L-glutamate + sulfoacetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42108", "l": "(20S)-hydroxypregn-4-en-3-one + NAD(+) = H(+) + NADH + progesterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474266", "l": "Formation of collagen fibrils (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606288", "l": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59488", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159771", "l": "Furin cleaves pro-protein C to protein C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805792", "l": "p-S291-PHF20 translocates to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38164", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA => 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16694", "l": "alpha-pinene oxide => (Z)-2-methyl-5-isopropylhexa-2,5-dienal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218906", "l": "RIPK3 phosphorylates MLKL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43242", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62002", "l": "3 AH2 + protoporphyrin IX => 3 A + protoporphyrinogen IX"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043843", "l": "ADP-specific glucokinase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004733", "l": "pyridoxamine-phosphate oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55316", "l": "3 H2O + hydrogen sulfide + 3 NAD(+) = 4 H(+) + 3 NADH + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12754", "l": "glycerol + NADP(+) => dihydroxyacetone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31402", "l": "all-trans-4,4'-diapophytofluene + FAD + H(+) <=> all-trans-4,4'-diapo-zeta-carotene + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69116", "l": "Formation of Okazaki fragments (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31489", "l": "H(+) + soyasaponin III + UDP => soyasapogenol B 3-O-beta-D-glucuronate + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56794", "l": "2 [corrinoid adenosyltransferase]-cob(I)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] => 2 cob(II)alamin--[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52469", "l": "16alpha,17beta-estriol + UDP-alpha-D-glucuronate => 16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676596", "l": "TRAF3 binds BAFFR:BAFF (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8957389", "l": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029270", "l": "Recruitment of PLCgamma to membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853793", "l": "p-5Y-RET complexes bind GRB2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32374", "l": "all-trans-violaxanthin + 2 L-ascorbate <=> all-trans-zeaxanthin + 2 H2O + 2 L-dehydroascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.11", "l": "\"Tryptophan 2,3-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29608", "l": "H2O + NAD(+) + nitrous oxide => H(+) + NADH + 2 nitric oxide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016464", "l": "chloroplast protein-transporting ATPase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211950", "l": "CYP24A1 24-hydroxylates CTL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-984606", "l": "Kinesin-5 is a homotetramer (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37149", "l": "1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52686", "l": "H(+) + NADH + pyridoxal => NAD(+) + pyridoxine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17519", "l": "a long-chain fatty acid + L-glutamate => H2O + N-(long-chain-fatty-acyl)-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49363", "l": "2',2'-dihydroxy-2-oxospirilloxanthin <=> 2,2'-dioxospirilloxanthin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.29"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799761", "l": "TP53 binds PPP1R13L (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65099", "l": "a 2-acylglycerol + hexadecanoyl-CoA <=> a 1-hexadecanoyl-2-acylglycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22920", "l": "L-glutamine + scyllo-inosose = 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate"}, {"i": "EC:2.6.1.50", "l": "\"Glutamine--scyllo-inositol transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27435", "l": "glutathione amide disulfide + H(+) + NADH => 2 glutathione amide + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875661", "l": "GGA3 associates with activated MET receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13856", "l": "4-methylene-L-glutamate + ATP + NH4(+) <=> 4-methylene-L-glutamine + AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-167419", "l": "The receptor:G-protein complex releases GDP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49853", "l": "(3E)-octenoyl-CoA => (2E)-octenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40439", "l": "6-sulfo-D-quinovose = 6-deoxy-6-sulfo-D-fructose"}, {"i": "EC:5.3.1.31", "l": "\"Sulfoquinovose isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58463", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine <=> a monoacyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52238", "l": "3 A + Fe(2+) + 3 H2O + mycobilin b => 3 AH2 + 2 H(+) + heme b + 3 O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031785", "l": "type 1A melatonin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371435", "l": "Constitutive phosphorylation by GSK3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783880", "l": "PIPOX oxidises PPCA to P6C (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031849", "l": "olfactory receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43045", "l": "hexadecasphinganine + octadecanoyl-CoA => CoA + H(+) + N-octadecanoylhexadecasphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031761", "l": "fMet-Leu-Phe receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218822", "l": "CRK binds BCAR1 and or PXN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1606789", "l": "ARSB hydrolyses DS (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47846", "l": "CO2 + diphosphate + thiamine phosphate => 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32567", "l": "(2E)-geranyl diphosphate = (1R,4S)-camphene + diphosphate"}, {"i": "EC:4.2.3.116", "l": "\"(+)-camphene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-688137", "l": "RIP2 is K63 polyubiquitinated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1364044", "l": "PRLR:JAK2 dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103003", "l": "oleate peroxygenase activity"}, {"i": "MetaCyc:RXN-9804"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199161", "l": "Fc gamma receptors interact with antigen-bound IgG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6790038", "l": "Expression of HSP90B1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0032559", "l": "adenyl ribonucleotide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14029", "l": "A + H2O + selenite = AH2 + selenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265301", "l": "Corticotropin cleavage from POMC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70475", "l": "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6805981", "l": "HMGB1 release from cells (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23781", "l": "H2O + oxaloacetate + propanoyl-CoA => (2S,3S)-2-methylcitrate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35598", "l": "benzene-1,2,4-triol + O2 <=> 2 H(+) + maleylacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012835", "l": "GDIs block activation of RHOA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24441", "l": "ATP + H2O + phosphate(out) => ADP + H(+) + 2 phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.12", "l": "\"Ubiquitinyl hydrolase 1\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30179", "l": "oxalate + oxidized 2[4Fe-4S]-[ferredoxin] = 2 CO2 + reduced 2[4Fe-4S]-[ferredoxin]"}, {"i": "EC:1.2.7.10", "l": "\"Oxalate oxidoreductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16150", "l": "beta-nicotinamide D-ribonucleotide + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031710", "l": "neuromedin B receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15741", "l": "2,5-dichlorocyclohexa-2,5-dien-1,4-diol + NAD(+) = 2,5-dichlorohydroquinone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32817", "l": "Hg(2+)(out) => Hg(2+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1605736", "l": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-379464", "l": "COMT transfers Met to DOPAC to form HVA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64547", "l": "acetyl-CoA + 8 AH2 + ATP + 4 H(+) + holo-[ACP] + L-tyrosine + 7 malonyl-CoA + 2 S-adenosyl-L-methionine <=> 8 A + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.36", "l": "\"RING-type E3 ubiquitin transferase (cysteine targeting)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664879", "l": "ATM:PEX5 binds ATM (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046523", "l": "S-methyl-5-thioribose-1-phosphate isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35078", "l": "doxorubicin(in) + H(+)(out) <=> doxorubicin(out) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56384", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 = (5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0005310", "l": "dicarboxylic acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071522", "l": "ureidoglycine aminohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48803", "l": "a neolactoside nLc4Cer + GDP-beta-L-fucose <=> a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854052", "l": "Formation of the SCF-FBXL7 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933537", "l": "Recruitment of TANK to TRAF6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953037", "l": "E2F8 forms homodimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33118", "l": "malonate(in) <=> malonate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396007", "l": "IRF3 is phosphorylated by TBK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53416", "l": "8-amino-8-demethylriboflavin + S-adenosyl-L-methionine = 8-demethyl-8-(methylamino)riboflavin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044020", "l": "histone methyltransferase activity (H4-R3 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31754", "l": "chlorophyllide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 7(1)-hydroxychlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41168", "l": "a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15848", "l": "4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP-alpha-D-glucose <=> 4-O-{[(2R)-2-alpha-D-glucosyl-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n H(+) + n UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22131", "l": "(1S,2R,4S)-borneol + NAD(+) <=> (1S,4S)-camphor + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111930", "l": "Adenylate cyclase produces cAMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878117", "l": "RUNX3 binds ZFHX3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1226016", "l": "Binding of GRB2:GAB1 complex to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14146", "l": "ATP + guanidinoacetate => ADP + H(+) + phosphoguanidinoacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432054", "l": "Aquaporin-1 passively transports water out of cell (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434004", "l": "viral dsRNA binds the toll-like receptor 3 (TLR3) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112429", "l": "Formation of FACT complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9724290", "l": "GNRHR2 binds GNRH1,2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29887", "l": "ATP + H2O + L-lysine(out) = ADP + H(+) + L-lysine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203901", "l": "Pol II mediated transcription of microRNA genes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5604929", "l": "Activated protein C binds Protein S (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60730", "l": "3,7-dimethylocta-2,6-dienoate + 2 H(+) + NADPH => citral + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4084505", "l": "Laminins bind HSPG2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932037", "l": "RUNX1 and ESR1 bind the KCTD6 gene enhancer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660829", "l": "ADORA2B binds Ade-Rib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015209", "l": "cytosine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102350", "l": "trans-cerot-2-enoyl-CoA reductase activity"}, {"i": "MetaCyc:RXN-13309"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64116", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9663511", "l": "BIL binds GSTA1, FABP1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60778", "l": "CO2 + gibberellin A15 + succinate => 2-oxoglutarate + gibberellin A12 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664850", "l": "ATM binds PEX5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102486", "l": "dCTP phosphohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2423785", "l": "CR:atREs binds apoE and HSPG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009000", "l": "selenocysteine lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56494", "l": "gypsogenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => hederagenin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903089", "l": "5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44181", "l": "2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57293", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O => a guanosine in RNA + glycolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47136", "l": "ATP + CoA + lithocholate = AMP + diphosphate + lithocholoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59278", "l": "D-glutamine => L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62874", "l": "H2O + NADP(+) + semiviriditoxin => (3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46816", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800052", "l": "SREBP1A,1C binds the SCD gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54168", "l": "a 5'-(N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-(N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390044", "l": "YKI is phosphorylated by and then dissociates from phosphorylated WTS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47842", "l": "(4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate => [5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655142", "l": "RCHY1 binds POLH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061661", "l": "FAT10 ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2247513", "l": "STAB1:ligand is endocytosed (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0140333", "l": "glycerophospholipid flippase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388829", "l": "SHP2 phosphatase binds CTLA-4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38048", "l": "2 [Fe(II)-cytochrome b5] + a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (9Z,12E)-octadecadienoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199935", "l": "MSK1 activates CREB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045547", "l": "dehydrodolichyl diphosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24874", "l": "H2O + O-phospho-D-serine => D-serine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36764", "l": "alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose => beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47128", "l": "ATP + CoA + deoxycholate = AMP + deoxycholoyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018784", "l": "(S)-2-haloacid dehalogenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050275", "l": "scopoletin glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.71", "l": "\"Arylamine glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39344", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA => (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12323", "l": "17-O-acetylnorajmaline + NADP(+) <=> 1,2-dihydrovomilenine + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40572", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52032", "l": "H2O + L-isoleucine-(+)-7-isojasmonate = (+)-7-isojasmonate + L-isoleucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371527", "l": "HSF1 trimer translocates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20596", "l": "H2O + N-acetyl-D-glucosamine <=> acetate + D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66852", "l": "(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52506", "l": "9(R)-hydroxy-(10E,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5632668", "l": "SMO translocates to the cilium (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362549", "l": "Hh-Np traffics to the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9614271", "l": "Autocleavage of ADGRG6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19491", "l": "2'-hydroxybiphenyl-2-sulfinate + FMN-N(5)-oxide + 2 H(+) => dibenzothiophene 5,5-dioxide + FMNH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43344", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+) = [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate"}, {"i": "EC:2.7.7.73", "l": "\"Sulfur carrier protein ThiS adenylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9007926", "l": "ATRX binds DAXX (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34894", "l": "selenite(in) <=> selenite(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0022885", "l": "bacteriocin transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63345", "l": "ATP + L-amino acyl-L-threonyl-[protein] => (S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202731", "l": "JAM3 dimerises (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047459", "l": "3-aminobutyryl-CoA ammonia-lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45541", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29014", "l": "2-oxoglutarate(in) + H(+)(in) <=> 2-oxoglutarate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11319", "l": "an aliphatic aldoxime <=> a nitrile + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58368", "l": "(2E,6Z)-nona-2,6-dien-1-ol + NADP(+) = (2E,6Z)-nona-2,6-dienal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.74", "l": "\"1,4-dihydroxy-2-naphthoate polyprenyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3229181", "l": "CALM1:Ca2+ binds CNG channel (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871266", "l": "YAP1 binds TEAD3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212356", "l": "Formation of CSL-NICD coactivator complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53971", "l": "apo-[BtrI ACP] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[BtrI ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627104", "l": "XIAP binds CASP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981809", "l": "ST6GALNAC3/4 can add a sialic acid to the sialyl T antigen to form the disialyl T antigen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23588", "l": "oxalate + succinyl-CoA = oxalyl-CoA + succinate"}, {"i": "EC:2.8.3.2", "l": "\"Oxalate CoA-transferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "81.790986234327661", "identifiers": [{"i": "GO:0016655", "l": "oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"}, {"i": "EC:1.6.5.-", "l": "\"With a quinone or similar compound as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31205", "l": "3-oxooctanoyl-CoA + CoA => acetyl-CoA + hexanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27695", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate => (S)-3-methyl-2-oxopentanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47751", "l": "a ubiquinone + H(+) + n Na(+)(in) + NADH <=> a ubiquinol + n Na(+)(out) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0051015", "l": "actin filament binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015018", "l": "galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity"}, {"i": "REACT:R-HSA-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430158", "l": "p-SLP-76 binds VAV (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13843", "l": "[transferrin[Fe(III)2]] + NADH => [transferrin[Fe(II)2]] + H(+) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247960", "l": "Activation of p38 MAPK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865182", "l": "OTUD7A hydrolyses K11diUb (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51060", "l": "5alpha-androst-1-ene-3,17-dione + A = AH2 + androsta-1,4-diene-3,17-dione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2197697", "l": "Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936851", "l": "AHRR binds ARNT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050383", "l": "uracil dehydrogenase activity"}, {"i": "RHEA:13469", "l": "A + H2O + thymine = 5-methylbarbiturate + AH2 + H(+)"}, {"i": "RHEA:22752", "l": "A + H2O + uracil = AH2 + barbiturate + H(+)"}, {"i": "EC:1.17.99.4", "l": "\"Uracil/thymine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70613", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388833", "l": "Phosphorylation of CTLA-4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021888", "l": "MECP2 binds CREB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693125", "l": "RHOF binds effectors at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5227009", "l": "ABCF1 binds EIF2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27574", "l": "(3R)-piperidine-3-carboxamide + H2O = (3R)-piperidine-3-carboxylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56259", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-threonyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2038386", "l": "Dimerization of FGFR3 t(4;14) translocation mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683630", "l": "Nucleoprotein translocates to the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989755", "l": "Expression of CYP4A11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51400", "l": "octadecanoyl-CoA + serotonin = CoA + H(+) + N-octadecanoyl-serotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419279", "l": "Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672817", "l": "Active MTORC1 binds the ULK1 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909729", "l": "Activation of JAK kinases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672329", "l": "IQGAP1 binds CLIP1 and microtubules (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.75"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50183", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 <=> N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47682", "l": "D-tagatose 1-phosphate + NH4(+) => D-galactosamine 6-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64443", "l": "glycylglycyl-L-proline(out) + H(+)(out) <=> glycylglycyl-L-proline(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52077", "l": "13-(9Z-hexadecenoyloxy)-octadecanoate + H2O => (9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50259", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34789", "l": "a 3-oxosteroid + H(+) + NADPH => a 3beta-hydroxysteroid + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050374", "l": "UDP-galacturonate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65973", "l": "a peptide antigen(in) + ATP + H2O => a peptide antigen(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.15", "l": "\"Renin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59386", "l": "3-(4-aminophenyl)pyruvate + L-glutamate => 2-oxoglutarate + 4-amino-L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903135", "l": "cupric ion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75172", "l": "Formation of RAD50:MRE11 complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35170", "l": "minocycline(in) <=> minocycline(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18894", "l": "a flavonol 3-O-beta-D-glucoside + UDP-alpha-D-glucose => a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168038", "l": "Collagen type XV restin release (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110215", "l": "Cleavage of uracil by UNG glycosylase (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5628901", "l": "TP53 stimulates TIGAR expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13307", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + UDP => E-sinapate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36603", "l": "2-oxoglutarate + L-enduracididine + O2 = (3S)-3-hydroxy-L-enduracididine + CO2 + succinate"}, {"i": "EC:1.14.11.40", "l": "\"Enduracididine beta-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33403", "l": "ATP + L-threonine = diphosphate + L-threonyl-5'-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63564", "l": "apelin-13 + H2O = apelin-12 + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352268", "l": "Cleavage of Satb1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008955", "l": "peptidoglycan glycosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.27"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60158", "l": "ADP + D-galactose(in) + H(+) + phosphate => ATP + D-galactose(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.297", "l": "\"Limonene-1,2-diol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937177", "l": "AHR:TCDD binds ARNT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58141", "l": "acetyl-AMP + cytidine(34) in elongator tRNA(Met) => AMP + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59998", "l": "(E)-cinnamate + reduced [electron-transfer flavoprotein] => 3-phenylpropanoate + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432510", "l": "CLK is degraded by the 26S proteasome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177934", "l": "EGFR autophosphorylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28415", "l": "gamma-L-glutamylputrescine + H2O + O2 => 4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61064", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018454", "l": "acetoacetyl-CoA reductase activity"}, {"i": "RHEA:22256", "l": "a (3R)-3-hydroxyacyl-CoA + NADP(+) = a 3-oxoacyl-CoA + H(+) + NADPH"}, {"i": "RHEA:45796", "l": "(3R)-3-hydroxybutanoyl-CoA + NADP(+) = acetoacetyl-CoA + H(+) + NADPH"}, {"i": "EC:1.1.1.36", "l": "\"Acetoacetyl-CoA reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14285", "l": "sn-glycerol 3-phosphate + UDP-alpha-D-galactose = 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP"}, {"i": "EC:2.4.1.137", "l": "\"sn-glycerol-3-phosphate 2-alpha-galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209297", "l": "PYGO binds to the LGS:ARM complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32504", "l": "linalool + O2 + reduced [NADPH--hemoprotein reductase] => (6E)-8-hydroxylinalool + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578712", "l": "Importin-8 binds AGO2:miRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64518", "l": "H(+) + NADH + sulfoacetaldehyde => 2-hydroxyethane-1-sulfonate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54330", "l": "hexadecan-1-ol + holo-[ACP] + 2 NADP(+) => 2 H(+) + hexadecanoyl-[ACP] + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26259", "l": "dehydroabietadienal + 2 H2O + NADP(+) => dehydroabietadienol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19611", "l": "4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine => adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34079", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + ADP + H(+) = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24080", "l": "ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)"}, {"i": "EC:6.1.1.2", "l": "\"Tryptophan--tRNA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416562", "l": "p190RhoGAP binds Plexin-B1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047627", "l": "adenylylsulfatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193656", "l": "p75NTR interacts with RIP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687107", "l": "MAPK4,6 translocate to nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47741", "l": "1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate => CO2 + demethylphylloquinone + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31445", "l": "ADP + H(+) + sedoheptulose 1,7-bisphosphate => ATP + D-sedoheptulose 7-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247569", "l": "PADI4 deiminates Histones (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112514", "l": "JAK activation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809764", "l": "SBF1 binds MTMR2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141046", "l": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63933", "l": "abscisate(in) + ATP + H2O => abscisate(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61166", "l": "H(+) + kaempferol 3-O-alpha-L-rhamnoside + UDP => kaempferol + UDP-beta-L-rhamnose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047507", "l": "(deoxy)nucleoside-phosphate kinase activity"}, {"i": "RHEA:11216", "l": "a 2'-deoxyribonucleoside 5'-phosphate + ATP = a 2'-deoxyribonucleoside 5'-diphosphate + ADP"}, {"i": "EC:2.7.4.13", "l": "\"(Deoxy)nucleoside-phosphate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59380", "l": "4-amino-4-deoxyprephenate + NAD(+) = 3-(4-aminophenyl)pyruvate + CO2 + H(+) + NADH"}, {"i": "EC:1.3.1.121", "l": "\"4-amino-4-deoxyprephenate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693536", "l": "ATM phosphorylates MDC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264865", "l": "Caspase-mediated cleavage of Lamin A (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703008", "l": "tamatinib-resistant FLT3 mutants don't bind tamatinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37318", "l": "glycyl-L-glutamine + H2O <=> glycine + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20775", "l": "2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) <=> 5-amino-6-(D-ribitylamino)uracil + riboflavin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61565", "l": "a tetracycline + H(+) + NADPH + O2 => a (1S,10aS)-3-(CONH2)-1-(Me2N)-3,3a,4,6-(HO)4-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracene + CO + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.135", "l": "\"N(4)-acetylcytidine amidohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49906", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO2 + H2O2 => (1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6794347", "l": "Homer1,2,3 dimerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168767", "l": "JAK2 phosphorylates STAT1/STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951966", "l": "EP300 acetylates RUNX3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4167511", "l": "HLCS biotinylates ACACB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47945", "l": "(2E)-geranyl diphosphate + H2O => (2E)-geranyl phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209792", "l": "N-acetylation of serotonin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66870", "l": "4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + quiannulatate => 3 O2 + quiannulatene + 3 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49128", "l": "AH2 + N-acetyl-demethyl-L-phosphinothricin + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + A + 2 H(+) + L-methionine + N-acetyl-L-phosphinothricin + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.326", "l": "\"N-acetyl-demethylphosphinothricin P-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036422", "l": "heptaprenyl diphosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46761", "l": "2,4-dinitrotoluene + NADH + O2 => 4-methyl-5-nitrocatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106162", "l": "mRNA N-acetyltransferase activity"}, {"i": "RHEA:58480", "l": "a cytidine in mRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9007901", "l": "IL1F10 binds IL1RL2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22984", "l": "carbamoyl phosphate + oxamate = N-carbamoyl-2-oxoglycine + phosphate"}, {"i": "EC:2.1.3.5", "l": "\"Oxamate carbamoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48472", "l": "ganglioside GT1a + H2O = ganglioside GD1a + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033722", "l": "malonate-semialdehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354077", "l": "Integrin alphaIIb beta3 activation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75080", "l": "Formation of AT-AC A complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23964", "l": "(E)-coniferaldehyde + H2O + NADP(+) = (E)-ferulate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62534", "l": "2 [Fe(III)cytochrome c] + dihydrodigitoxin => 2 [Fe(II)cytochrome c] + digitoxin + 3 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21691", "l": "a polyvinyl alcohol + n O2 <=> an oxidized polyvinyl alcohol + n H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202331", "l": "Recruitment of PLC-gamma1 to SLP-76 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28829", "l": "L-ornithine(in) + putrescine(out) => L-ornithine(out) + putrescine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43549", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693356", "l": "CEMIP hydrolyses HA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6794346", "l": "NRXNs bind NLGNs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23403", "l": "7,8-dihydroxykynurenate + O2 <=> 5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6802973", "l": "PLK3 phosphorylates CDC25C (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41572", "l": "lipoxin A4 + NAD(+) = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46484", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112429", "l": "Formation of FACT complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106267", "l": "3,5 dichloro-THPH synthase activity"}, {"i": "RHEA:64360", "l": "(3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 = (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985929", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34526", "l": "[alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose <=> [alpha-D-GalNAc-(1->4)]2-[beta-D-Glc-(1->3)]-[alpha-D-GalNAc-(1->4)]2-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23683", "l": "a ribonucleoside 5'-triphosphate + H2O <=> a ribonucleoside 5'-diphosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22395", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928624", "l": "EPHBs bind EFNBs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14317", "l": "morphine + NAD(+) = H(+) + morphinone + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26286", "l": "Co-precorrin-5B + S-adenosyl-L-methionine => Co-precorrin-6A + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21065", "l": "[protein]-disulfide + 2 glutathione => [protein]-dithiol + glutathione disulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653840", "l": "POLD,POLE complete replication of damaged DNA after TLS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47015", "l": "[DsrC protein]-disulfide + H(+) + hydrogen sulfide <=> [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62938", "l": "2'-deoxycytidine + acetate + H(+) => H2O + N(4)-acetyl-2'-deoxycytidine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016309", "l": "1-phosphatidylinositol-5-phosphate 4-kinase activity"}, {"i": "MetaCyc:2.7.1.149-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050635", "l": "acridone synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41557", "l": "2-oxoglutarate + L-arginyl-[ribosomal protein uL16] + O2 => (3R)-3-hydroxy-L-arginyl-[ribosomal protein uL16] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31268", "l": "6-hydroxyhexanoate + NADP(+) => 6-oxohexanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4568737", "l": "AP-1 transcription factor binds IL1A promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15241", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.105", "l": "\"Taxane 10-beta-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50428", "l": "methanethiol + S-adenosyl-L-methionine = dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.334", "l": "\"Methanethiol S-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1980125", "l": "ITCH binds DTX (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1564169", "l": "Collagen type VIII degradation by MMP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44700", "l": "a 2,3-saturated acyl-CoA + FAD + H(+) = a (2E)-enoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74718", "l": "Internalisation of the insulin receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59905", "l": "H2O + NADP(+) + octanal => 2 H(+) + NADPH + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16653", "l": "D-gluconate + NADP(+) = 2-dehydro-D-gluconate + H(+) + NADPH"}, {"i": "EC:1.1.1.215", "l": "\"Gluconate 2-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-994148", "l": "LRRC16A binds F-actin capping protein (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71303", "l": "RPE dimers isomerise RU5P to XY5P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0008242", "l": "omega peptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56463", "l": "H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161293", "l": "Tropoelastin forms aggregate globules (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0051002", "l": "ligase activity, forming nitrogen-metal bonds"}, {"i": "EC:6.6.-.-", "l": "\"Forming nitrogen-metal bonds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2129362", "l": "Fibrillin microfibril assembly (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14040", "l": "4,5beta-dihydrocortisone + NADP(+) <=> cortisone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209903", "l": "Noradrenaline is converted to adrenaline (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50320", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60313", "l": "L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22840", "l": "D-glutamine + H2O = D-glutamate + NH4(+)"}, {"i": "EC:3.5.1.35", "l": "\"D-glutaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46768", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-acyl-2-[(9Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.19.27", "l": "\"sn-2 palmitoyl-lipid 9-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31953", "l": "9beta-pimara-7,15-dien-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786650", "l": "DDHD1,2 hydrolyse PA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166726", "l": "Activation of MASPs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23189", "l": "NAD(+) + propane-1,3-diol => 3-hydroxypropanal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140842", "l": "n fibrin monomers -> fibrin multimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37908", "l": "(9Z)-octadecenoate + O2 => (8E,10S)-10-hydroperoxy-octadeca-8-enoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57516", "l": "dolabradiene + O2 + reduced [NADPH--hemoprotein reductase] = 15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "RHEA:57520", "l": "15,16-epoxydolabrene + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxy-15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.159", "l": "\"Dolabradiene monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11430", "l": "D-glucono-1,5-lactone + H2O2 => beta-D-glucose + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12998", "l": "(E)-feruloyl-CoA + galactarate => 2-O-[(E)-feruloyl]-D-galactarate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32088", "l": "[4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphoenolpyruvate => [4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-(S)-4,6-CH3(COO(-))C-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102768", "l": "anthocyanidin synthase activity"}, {"i": "MetaCyc:RXN-7785"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009309", "l": "RUNX2 binds STUB1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46637", "l": "5beta-dihydrotestosterone + NADP(+) => H(+) + NADPH + testosterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696274", "l": "RND1 binds GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40245", "l": "3-oxohexadecanoyl-CoA + H(+) + NADH => (3R)-hydroxyhexadecanoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57736", "l": "A + all-trans-3,4-didehydro-13,14-dihydroretinol = AH2 + all-trans-3,4-didehydroretinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625828", "l": "FOXO1 binds RETN gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247839", "l": "Retromer associates with WLS (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57392", "l": "(13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine = 3-O-acetyl-4'-O-demethylpapaveroxine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392212", "l": "G alpha (i) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28931", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate = 4-carboxy-2-hydroxy-cis,cis-muconate"}, {"i": "EC:5.3.2.8", "l": "\"4-oxalomesaconate tautomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56106", "l": "4,4'-diaponeurosporenal + 2 A + 3 H2O => 2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47061", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190520", "l": "Association of Golgi  transport vesicles with microtubules (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55172", "l": "2-oxoglutarate + hexanoyl-CoA + O2 = 2-hydroxyhexanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097657", "l": "3',5'-nucleotide bisphosphate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451311", "l": "Activation of Ca-permeable Kainate receptors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102662", "l": "malonate-semialdehyde dehydrogenase (acetylating, NAD+) activity"}, {"i": "RHEA:22992", "l": "3-oxopropanoate + CoA + NAD(+) = acetyl-CoA + CO2 + NADH"}, {"i": "MetaCyc:RXN-2902"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624132", "l": "UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-169827", "l": "DPDK1 phosphorylates and activates DS6K (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102588", "l": "cyanidin 3-O-glucoside 6''-O-malonyltransferase activity"}, {"i": "MetaCyc:RXN-15335"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60003", "l": "hydroxymethylphosphonate + O2 <=> formate + 2 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0051733", "l": "polydeoxyribonucleotide kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38137", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610720", "l": "PKA phosphorylates GLI3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63782", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465940", "l": "atRAL is reduced to atROL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45277", "l": "12-phosphooxy-(9E)-octadecenoate + H2O => 12-hydroxy-(9E)-octadecenoate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944220", "l": "Association of procollagen type XXIII (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444859", "l": "Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36925", "l": "3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + CO2 + CoA => (19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.46", "l": "\"6-aminohexanoate-oligomer exohydrolase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050313", "l": "sulfur dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18967", "l": "H2O + uroporphyrinogen III => hydroxymethylbilane"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12466", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + H(+) + UDP => myo-inositol + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42889", "l": "(R)-3-phosphomevalonate + ATP => (R)-3,5-bisphosphomevalonate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170986", "l": "Ral-GDS binds to Ras-GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59707", "l": "D-cellohexaono-1,5-lactone + H2O <=> D-cellohexaonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49530", "l": "(ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+) => (ethylene terephthalate)(n) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49869", "l": "(+)-dehydrodiconiferyl acid + a quinone => (+)-dehydrodiconiferyl acid ketone + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199579", "l": "KIR2DL4 interacting with HLA-G (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018814", "l": "RHOT1 hydrolyzes GTP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44150", "l": "D-beta-lysine => L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40518", "l": "6-deoxy-6-sulfo-D-fructose 1-phosphate <=> 3-sulfolactaldehyde + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9007447", "l": "E2F6 forms the PRC1L4 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017125", "l": "deoxycytidyl transferase activity"}, {"i": "REACT:R-HSA-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814094", "l": "ARL1:GTP binds ARFIP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37481", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9649108", "l": "HTR3A pentamer binds 5HT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29373", "l": "2'-deoxyadenosine + phosphate => dAMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17402", "l": "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate => 4-carboxy-2-hydroxy-cis,cis-muconate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50921", "l": "2 2-iminio-3-(indol-3-yl)propanoate + H2O2 => chromopyrrolate + H(+) + 2 H2O + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10186", "l": "3-oxoadipate + H(+) => (4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382058", "l": "Nck binds to the active PDGF receptor (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51211", "l": "20-hydroxy-leukotriene B4 + NADP(+) <=> 12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687121", "l": "nsp8 binds MAP1LC3B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33275", "l": "a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35778", "l": "L-glutamine + UDP-3-oxo-alpha-D-glucose <=> 2-oxoglutaramate + UDP-alpha-D-kanosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327886", "l": "SLRPs bind TGF Beta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174119", "l": "Free APC/C phosphorylated by Plk1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1449597", "l": "p-AKT2 phosphorylates Myosin 5A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64139", "l": "H2O + N-(9Z-octadecenoyl)-L-asparagine <=> (9Z)-octadecenoate + L-asparagine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62982", "l": "(9Z)-hexadecenoate + NH4(+) => (9Z)-hexadecenamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167134", "l": "Newly formed phosphodiester bond stabilized and PPi released (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10161", "l": "L-iditol + NAD(+) => H(+) + keto-L-sorbose + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047349", "l": "D-ribitol-5-phosphate cytidylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12188", "l": "2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase]-(R)-N(6)-lipoyl-L-lysine + H(+) = [dihydrolipoyllysine-residue succinyltransferase]-(R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysine + CO2"}, {"i": "EC:1.2.4.2", "l": "\"Oxoglutarate dehydrogenase (succinyl-transferring)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686710", "l": "Cleavage of S protein into S1:S2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211924", "l": "CYP4B1 12-hydroxylates ARA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17960", "l": "3-oxopropanoate <=> H2O + propynoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19113", "l": "(8Z,11Z,14Z)-heptadecatrienal + A + H2O = (8Z,11Z,14Z)-heptadecatrienoate + AH2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25558", "l": "diphosphate + stemod-13(17)-ene => 9alpha-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29889", "l": "ADP + H(+) + L-lysine(in) + phosphate => ATP + H2O + L-lysine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9681616", "l": "AP2 binds chlorpromazine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696465", "l": "USP45 deubiquitinates ERCC1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45802", "l": "10-decarboxymethylaclacinomycin T + A + CO2 + H2O => 15-demethylaclacinomycin T + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31085", "l": "L-alanine + N-acetyl-D-muramate => H2O + N-acetyl-D-muramoyl-L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10511", "l": "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate <=> aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49980", "l": "H2O + hexanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12719", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+) => 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35631", "l": "cyanidin + UDP-alpha-D-galactose = cyanidin 3-O-beta-D-galactoside + H(+) + UDP"}, {"i": "EC:2.4.1.294", "l": "\"Cyanidin 3-O-galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63777", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4093342", "l": "SDC2 multimerises (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168038", "l": "Collagen type XV restin release (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41260", "l": "L-tryptophan => (E)-3-(indol-3-yl)acrylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797974", "l": "LRRTMs bind NRXNs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551727", "l": "CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201622", "l": "Caspase-mediated cleavage of gelsolin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592387", "l": "Fibulin binds elastic fibres (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53754", "l": "a 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-beta-D-galactopyranosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43590", "l": "globoside NOR2 + H(+) + UDP => globoside NORint + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20624", "l": "ATP + H2O + Zn(2+)(in) <=> ADP + H(+) + phosphate + Zn(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39850", "l": "a 2-acylglycerol + ATP <=> a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60265", "l": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16236", "l": "(R)-pantoate + NADP(+) <=> 2-dehydropantoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2248891", "l": "Active ARSA translocates to the lysosome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55041", "l": "(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44751", "l": "5-amino-1-(beta-D-ribosyl)imidazole + ATP <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24075", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate <=> 12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46095", "l": "(25R)-cholest-5-ene-3beta,26-diol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta-hydroxy-5-cholesten-26-al + 2 H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140592", "l": "histone methyltransferase activity (H3-R8 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010292", "l": "GTP:GDP antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61548", "l": "ent-kaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = ent-7alpha-hydroxykaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26560", "l": "(2E)-butenoyl-CoA + H2O => (3S)-3-hydroxybutanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35243", "l": "ADP + H(+) + thiamine diphosphate = adenosine thiamine triphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56117", "l": "2-all-trans-decaprenylphenol + H(+) + NADPH + O2 => 3-(all-trans-decaprenyl)benzene-1,2-diol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417825", "l": "P2Y11 receptor can bind to ATP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874078", "l": "PTK2 autophosphorylates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193695", "l": "IRAK interacts with TRAF6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63092", "l": "H(+) + ilicicolin A + NADPH + O2 = H2O + ilicicolin A epoxide + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61482", "l": "an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+) => a sphingoid base + a very long-chain fatty acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985627", "l": "RUNX2 and RB1 bind the COL1A1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59784", "l": "H2O + NADP(+) + pseudopaline = (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35506", "l": "11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 30-hydroxy-11-oxo-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15038", "l": "putrescine + S-adenosyl-L-methionine => H(+) + N-methylputrescine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351948", "l": "Mitochondrial recruitment of Drp1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389862", "l": "Conversion of glyoxylate to oxalate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50468", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 27 H(+) + 9 malonyl-CoA + 18 NADPH = 19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 9 H2O + 18 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36505", "l": "(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA => (9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71825", "l": "G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-447130", "l": "Interleukin-23 binds interleukin-23 receptor (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701485", "l": "Active ALK binds JAK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654404", "l": "Activated FGFR2 binds SHC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247844", "l": "WNT ligands traffic to the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56829", "l": "2,3,6-trichlorohydroquinone + chloride + glutathione disulfide => 2,3,5,6-tetrachlorohydroquinone + 2 glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64616", "l": "(E)-coniferol + acetyl-CoA = (E)-coniferyl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44241", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol => a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + di-(9Z)-octadecenoylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67031", "l": "(glutathione)4[2Fe(III)-2S] cluster(in) + ATP + H2O <=> (glutathione)4[2Fe(III)-2S] cluster(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9611851", "l": "ADRB2 bind ADR,NAd (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30604", "l": "15-cis-phytoene + A => AH2 + all-trans-phytofluene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55170", "l": "[TtuB sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate => [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40434", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030741", "l": "inositol 1-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61110", "l": "(2R,3R)-dihydromyricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (2R,3R)-dihydrokaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693593", "l": "D-loop extension by DNA polymerases (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49993", "l": "H(+) + NADH + O2 + propane => H2O + NAD(+) + propan-2-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696275", "l": "RND2 binds GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11732", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoraflavanone B = H(+) + H2O + leachianone G + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.142", "l": "\"8-dimethylallylnaringenin 2'-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46968", "l": "A + dihydroisopentenyldehydrorhodopin = AH2 + isopentenyldehydrorhodopin"}, {"i": "RHEA:46972", "l": "A + dihydrobisanhydrobacterioruberin = AH2 + bisanhydrobacterioruberin"}, {"i": "EC:1.3.99.37", "l": "\"1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050226", "l": "psychosine sulfotransferase activity"}, {"i": "RHEA:14137", "l": "3'-phosphoadenylyl sulfate + beta-D-galactosyl-(1<->1)-sphing-4-enine = 6-O-sulfo-beta-D-galactosyl-(1<->1)-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)"}, {"i": "EC:2.8.2.13", "l": "\"Psychosine sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21610", "l": "2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine => isoliquiritigenin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158849", "l": "Phenol can form a sulfate conjugate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17213", "l": "UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-mannosamine"}, {"i": "EC:5.1.3.14", "l": "\"UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22778", "l": "2 H2O + 2 Mn(3+) => 2 H(+) + H2O2 + 2 Mn(2+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59985", "l": "an N(2)-acyl-L-glutamine + H2O => a carboxylate + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24685", "l": "5,10-methylenetetrahydromethanopterin + NADP(+) <=> 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27730", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli) = beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate"}, {"i": "RHEA:35371", "l": "2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A = (beta-L-Ara4N)2-(Kdo)2-lipid A + 2 di-trans,octa-cis-undecaprenyl phosphate"}, {"i": "EC:2.4.2.43", "l": "\"Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21311", "l": "(S)-2,3-epoxysqualene <=> cycloartenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3304394", "l": "Activated TGFBR1 cannot phosphorylate SMAD2 and SMAD3 Phosphorylation Motif Mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36516", "l": "H(+) + malonyl-CoA + tetracosanoyl-CoA => 3-oxohexacosanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45405", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate => 1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072555", "l": "17-beta-ketosteroid reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411367", "l": "TCF7L1/TCF7L2/LEF1:CTNNB1 bind the MYC gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59399", "l": "L-leucine <=> D-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.99.-", "l": "\"With other acceptors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61243", "l": "H2O + L-phenylalanine + O2 <=> 3-phenylpyruvate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20940", "l": "1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685953", "l": "SIRT6 deacetylates RBBP8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810843", "l": "Envoplakin binds periplakin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37938", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate <=> 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932327", "l": "NFE2L2 binds KEAP1:CUL3:RBX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-606287", "l": "RSF complex binds the centromere (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13254", "l": "1D-myo-inositol 1,3,4-trisphosphate + ATP => 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050041", "l": "lactate aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036397", "l": "formate dehydrogenase (quinone) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29073", "l": "a ubiquinol + CO2 => a ubiquinone + formate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36944", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351207", "l": "Spermine  => N-acetylated spermine (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29699", "l": "dimethyl sulfoxide(in) = dimethyl sulfoxide(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "78.819800280251172", "identifiers": [{"i": "GO:0030983", "l": "mismatched DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192123", "l": "CYP27A1 27-hydroxylates CHOL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38328", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15415", "l": "H2O + oxaloacetate => (2R,3R)-tartrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-450533", "l": "PKCdelta phosphorylates HuR (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23539", "l": "alpha-D-glucose 1-phosphate <=> alpha-D-glucose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57251", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-dGTP <=> dGTP + glycolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44464", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol = 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419003", "l": "Interaction of Nectins with Afadin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956676", "l": "YAP1 binds TP73 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14851", "l": "L-aspartate + urea => H2O + N-amidino-L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63186", "l": "H(+) + NAD(+) + 2 superoxide => NADH + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60524", "l": "5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine = 5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20245", "l": "ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate"}, {"i": "EC:2.7.7.47", "l": "\"Streptomycin 3''-adenylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15581", "l": "biochanin A 7-O-beta-D-glucoside + malonyl-CoA = biochanin A 7-O-beta-D-glucoside 6''-O-malonate + CoA"}, {"i": "EC:2.3.1.115", "l": "\"Isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604731", "l": "Autocatalytic activation of MMP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17196", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21520", "l": "2 [Fe(III)-cytochrome b1] + formate = 2 [Fe(II)-cytochrome b1] + CO2 + H(+)"}, {"i": "EC:1.2.2.1", "l": "\"Formate dehydrogenase (cytochrome)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070628", "l": "proteasome binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042292", "l": "URM1 activating enzyme activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21604", "l": "styrene oxide = 2-phenylacetaldehyde"}, {"i": "EC:5.3.99.7", "l": "\"Styrene-oxide isomerase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052823", "l": "2-hydroxy-6-oxonona-2,4,7-trienedioate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111956", "l": "Calmodulin activates Cam-PDE 1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65919", "l": "L-kynurenine + pyruvate <=> H2O + kynurenate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47557", "l": "H2O + taurodeoxycholate => deoxycholate + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852317", "l": "PLK1 phosphorylates GTSE1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64325", "l": "(11Z)-octadecenoyl-CoA + cholesterol => cholesteryl (11Z)-octadecenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013438", "l": "RHOD binds effectors at the endosome membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788999", "l": "HV1-mediated H+ transfer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17456", "l": "5-phospho-beta-D-ribosylamine + ATP + glycine <=> ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39557", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+) => 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24408", "l": "adenosine + H(+) + H2O = inosine + NH4(+)"}, {"i": "EC:3.5.4.4", "l": "\"Adenosine deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50800", "l": "glutathione + prostaglandin A2 = prostaglandin A2-S-(S)-glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10794", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2 => 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8847880", "l": "CYTH proteins bind ARF1:GTP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213195", "l": "Formation of anchoring fibrils (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2545203", "l": "Deacetylation of cleaved cohesin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63350", "l": "(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + ADP + H(+) + phosphate => ATP + L-amino acyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54915", "l": "11-cis-retinol + NADP(+) <=> 11-cis-retinal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217204", "l": "Activation and association of ATM kinase at the DNA damage sites (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380782", "l": "STAT binds to the active receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56272", "l": "4 [Fe(III)cytochrome cL] + H2O + methanol = 4 [Fe(II)cytochrome cL] + formate + 5 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39677", "l": "3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA => (9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52075", "l": "12-(9Z-hexadecenoyloxy)-octadecanoate + H2O <=> (9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730902", "l": "Oligomerization of p-CARMA1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28788", "l": "4-hydroxy-L-threonine + ATP => 4-(phosphooxy)-L-threonine + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50887", "l": "(9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O <=> (9Z-octadecenoyl)-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34158", "l": "acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine <=> CoA + H(+) + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34520", "l": "N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + 3 UDP-N-acetyl-alpha-D-galactosamine => [alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + 3 H(+) + 3 UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205136", "l": "GTP-bound RAC contributes to JNK activation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28940", "l": "H(+)(in) + xanthosine(in) => H(+)(out) + xanthosine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980078", "l": "NOTCH1 stimulates HES5 transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16821", "l": "6-phospho-D-gluconate + NAD(+) = 6-phospho-2-dehydro-D-gluconate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50077", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66539", "l": "A + cholest-4,6-dien-3-one + H2O <=> 25-hydroxycholest-4,6-dien-3-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791291", "l": "TP53 stimulates BID gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54554", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate => 1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42716", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate = (2E)-thiogeraniol + 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate"}, {"i": "EC:2.9.1.3", "l": "\"tRNA 2-selenouridine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10087", "l": "3,4-dihydroxybenzoate + O2 <=> 3-carboxy-cis,cis-muconate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45643", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14703", "l": "CoA-disulfide + H(+) + NADH => 2 CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446322", "l": "PARVA associates with Paxillin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62240", "l": "a thymidine(6-4)cytidine in DNA = a thymine-cytidine dinucleotide in DNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38662", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42518", "l": "H(+) + L-gulonate => H2O + L-gulono-1,4-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21726", "l": "a carboxylate + NH4(+) => a nitrile + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35715", "l": "(2S,3S)-versiconal hemiacetal acetate + H2O = (2S-3S)-versiconal hemiacetal + acetate + H(+)"}, {"i": "RHEA:35719", "l": "(3S)-versiconol acetate + H2O = (S)-versiconol + acetate + H(+)"}, {"i": "EC:3.1.1.94", "l": "\"Versiconal hemiacetal acetate esterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3134914", "l": "Beta-catenin migrates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.67", "l": "\"11-hydroxysugiol 20-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419841", "l": "Light stimulates opsin receptors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804099", "l": "HMGB1 binds LTP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48558", "l": "4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate => 4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38860", "l": "beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP-alpha-D-glucose => bis(beta-D-gentiobiosyl) crocetin + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1462005", "l": "pro-defensin alpha 5 is secreted (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64929", "l": "dADP + H2O => dAMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2855077", "l": "Ficolin-3 binds to molecular patterns on the target cell surface  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692779", "l": "p-S182 MAPKAPK5 phosphorylates FOXO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44059", "l": "2-O-hexadecanoyl-alpha,alpha-trehalose + hexadecanoyl-CoA <=> 2-O,3-O-dihexadecanoyl-alpha,alpha-trehalose + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17109", "l": "FMNH2 + N-methylnicotinate + O2 = (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FMN + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592362", "l": "Activation of proMMP7 by MMP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32419", "l": "(1S,2R,4R)-neoisodihydrocarveol + NAD(+) = (1S,4R)-isodihydrocarvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55040", "l": "(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]"}, {"i": "EC:2.3.1.179", "l": "\"Beta-ketoacyl-[acyl-carrier-protein] synthase II\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17386", "l": "H2O + hypotaurine + NAD(+) => H(+) + NADH + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.23"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102740", "l": "theobromine:S-adenosyl-L-methionine 1-N-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2737728", "l": "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14247", "l": "AMP + diphosphate + H(+) => ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71590", "l": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45386", "l": "(9Z)-octadecenoate + H(+) + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine => H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.8.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70899", "l": "histidine => urocanate + NH4+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62112", "l": "(3S)-3-hydroxy-D-aspartate = H2O + iminosuccinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38677", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070905", "l": "serine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655955", "l": "OLAH hydrolyzes decanoyl-FASN dimer to DECA and FASN dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29961", "l": "alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP => alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38119", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol = 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31820", "l": "(2E,6E)-farnesyl diphosphate => 5-epi-alpha-selinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49900", "l": "5,10-dihydrophenazine-1,6-dicarboxylate + O2 = H2O2 + phenazine-1,6-dicarboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46401", "l": "cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-cholest-5-ene-3beta,26-diol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29588", "l": "4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) => 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10125", "l": "H(+) + NADPH + O2 + phenylacetone => benzyl acetate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3858482", "l": "DVL is recruited to the receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36822", "l": "(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417843", "l": "P2Y13 binds ADP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13554", "l": "alpha-D-galactose + ATP => ADP + alpha-D-galactose 1-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37923", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52047", "l": "mogrol + UDP-alpha-D-glucose <=> H(+) + mogroside IE + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54364", "l": "2 acetaldehyde = acetoin"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0035004", "l": "phosphatidylinositol 3-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196017", "l": "Dynamin is recruited to the gap junction plaque (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939963", "l": "Activated AKT phosphorylates RUNX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848606", "l": "PTK6 phosphorylates PXN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29516", "l": "beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015325", "l": "acetyl-CoA:CoA antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18772", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate <=> 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28501", "l": "formaldehyde + mycothiol <=> S-(hydroxymethyl)mycothiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373177", "l": "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13680", "l": "D-ribulose 5-phosphate <=> D-xylulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38199", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54808", "l": "H(+) + L-isoleucine-(+)-7-isojasmonate + NADPH + O2 = H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042286", "l": "glutamate-1-semialdehyde 2,1-aminomutase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632182", "l": "PRMT1 methylates ESRs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40503", "l": "N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine = N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27347", "l": "5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate + H(+) => FMNH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10857", "l": "a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose => a 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphing-4-enine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046566", "l": "DOPA dioxygenase activity"}, {"i": "MetaCyc:RXN-8460"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102427", "l": "allocryptopine 6-hydroxylase activity"}, {"i": "MetaCyc:RXN-13828"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21034", "l": "acceptor beta-D-glucuronoside + H(+) + UDP => glucuronate acceptor + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607750", "l": "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016754", "l": "sinapoylglucose-malate O-sinapoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507871", "l": "Aquaporins passively transport glycerol out of cells (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15467", "l": "ADP + H(+) + sphinganine 1-phosphate => ATP + sphinganine"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0000700", "l": "mismatch base pair DNA N-glycosylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43974", "l": "H(+) + hexadecanoate + hexadecanoyl-glycero-3-phospho-(1D-myo-inositol) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010301", "l": "xanthoxin dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033995", "l": "anhydrosialidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928614", "l": "EFNB:GRB4 binds GIT1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193695", "l": "IRAK interacts with TRAF6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809309", "l": "MTMR6 binds MTMR9 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-391934", "l": "DP2 receptor can bind PGD2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5340214", "l": "CYGB binds O2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48471", "l": "ganglioside GM1b (d18:1(4E)) + H2O <=> ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65438", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidyl-adenosine in mRNA + diphosphate => a 5'-end triphospho-adenylyl-adenylyl-cytidyl-adenosine in mRNA + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357845", "l": "RIPK1 is deubiquitinated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41453", "l": "5-methyl-1-naphthoate + H(+) + NADPH + O2 => 3-hydroxy-5-methyl-1-naphthoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28558", "l": "D-fructose 6-phosphate + H2O = D-fructose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35929", "l": "3''-deamino-3''-hydroxykanamycin C + H(+) + UDP => paromamine + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428909", "l": "Activated TP receptor binds G-protein  G13 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56317", "l": "3-amino-4-hydroxybenzoate + acetyl-CoA => 3-acetylamino-4-hydroxybenzoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51752", "l": "a 2-acylphloroglucinol + dimethylallyl diphosphate = a 2-acyl-4-prenylphloroglucinol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24672", "l": "H(+) + NADH + xanthine => H2O + hypoxanthine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46771", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-acyl-2-[(9Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38403", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = (9Z,12Z)-octadecadienoate + 1,3-di-(9Z,12Z)-octadecadienoylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26399", "l": "2 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde => all-trans-zeaxanthin + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60305", "l": "N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008447", "l": "L-ascorbate oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5082391", "l": "Trimerization of HSF1 in the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49499", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + H(+) <=> 2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61872", "l": "1-O-methyl-(9Z,12Z)-octadecadienoate + O2 = 1-O-methyl-(9R)-hydroperoxy-(10E,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24210", "l": "1,5-anhydro-D-fructose + H(+) + NADPH => 1,5-anhydro-D-mannitol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948226", "l": "Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55345", "l": "(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol => 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10518", "l": "(1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH => (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51830", "l": "AMP(in) + diphosphate(in) + docosanoyl-CoA(in) + H(+)(in) => ATP(in) + CoA(in) + docosanoate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674808", "l": "CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3134800", "l": "STING dimerization (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4411383", "l": "NLK phosphorylates TCF/LEF (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23396", "l": "H2O + phloretin = 1,3,5-trihydroxybenzene + H(+) + phloretate"}, {"i": "EC:3.7.1.4", "l": "\"Phloretin hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33013", "l": "(+)-artemisinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-artemisinic aldehyde + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811431", "l": "RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001646", "l": "cAMP receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35109", "l": "4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+) => 3-nitrotyramine + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40873", "l": "(2E,9Z)-octadecadienoyl-CoA + FADH2 => (9Z)-octadecenoyl-CoA + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59787", "l": "H2O + NADP(+) + pseudopaline <=> (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210909", "l": "ANTXR1-bound pagA(197-794) forms oligomers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.n3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66872", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 9-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24101", "l": "diisopropyl fluorophosphate + H2O => diisopropyl phosphate + fluoride + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6789092", "l": "NOX2 generates superoxide anion from oxygen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29269", "l": "L-valine(out) + Na(+)(out) => L-valine(in) + Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13954", "l": "a D-aminoacyl-tRNA + H2O => a D-alpha-amino acid + H(+) + tRNA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047680", "l": "aryl-acylamidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004079", "l": "biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797090", "l": "CCNK binds CDK12 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947531", "l": "Molybdenum ion transfer onto molybdopterin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45951", "l": "acetyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29891", "l": "ATP + H2O + L-histidine(out) = ADP + H(+) + L-histidine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848606", "l": "PTK6 phosphorylates PXN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25985", "l": "(+)-epi-isozizaene + H(+) + NADPH + O2 => (5R)-albaflavenol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34488", "l": "dTDP-beta-L-rhamnose + N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol => alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192123", "l": "CYP27A1 27-hydroxylates CHOL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174119", "l": "Free APC/C phosphorylated by Plk1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391941", "l": "BLT receptors can bind LTB4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58097", "l": "1-tetracosanoylglycerol + H2O => glycerol + H(+) + tetracosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23258", "l": "adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate => adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870466", "l": "RGGT:CHM binds RABs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16358", "l": "A + succinate => AH2 + fumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53037", "l": "4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate => 4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.48"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665388", "l": "ERBB2 ECD mutants heterodimerize with EGFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36662", "l": "carbamoyl phosphate + descarbamoylnovobiocin <=> novobiocin + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59075", "l": "AH2 + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13912", "l": "phosphate + urate D-ribonucleoside <=> alpha-D-ribose 1-phosphate + urate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39707", "l": "a long-chain fatty acyl-CoA(out) = a long-chain fatty acyl-CoA(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047784", "l": "cortisol O-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004792", "l": "thiosulfate sulfurtransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004604", "l": "phosphoadenylyl-sulfate reductase (thioredoxin) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014467", "l": "RHOG binds effectors at the ER membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45255", "l": "tetradecanoate(out) <=> tetradecanoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33756", "l": "H2O + N-hexadecanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204773", "l": "Interaction of Tie2 and Grb7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961651", "l": "E2F1 binds the PCNA gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5226979", "l": "ADD1:ADD2 binds DMTN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607737", "l": "BCL10 oligomerizes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848077", "l": "PTK6 phosphorylates STAP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60375", "l": "D-fructose(out) <=> D-fructose(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114683", "l": "Phosphorylation of Platelet Sec-1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848774", "l": "PTK6 binds DOK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63565", "l": "apelin-13 + H2O => apelin-12 + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45896", "l": "an N-acyl-sphingoid base + CDP-ethanolamine = an N-acyl-sphingoid 1-phosphoethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64195", "l": "H2O + N-(9Z-octadecenoyl)-L-lysine <=> (9Z)-octadecenoate + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680242", "l": "Ligand-independent dimerization of KIT extracellular domain mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22002", "l": "D-xylono-1,5-lactone + H(+) + NADPH => D-xylose + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047997", "l": "hydroxypyruvate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982617", "l": "CYGB:O2 dissociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658574", "l": "PARK2 binds SNCAIP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16228", "l": "1,8-diazacyclotetradecane-2,9-dione + H2O <=> N-(6-aminohexanoyl)-6-aminohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21655", "l": "2-chlorobenzoate + H(+) + NADH + O2 <=> catechol + chloride + CO2 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660965", "l": "CCL17 and CCL22 genes are transcribed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42178", "l": "(9Z,12Z)-tetradecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (9Z)-tetradecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22406", "l": "D-galactaro-1,5-lactone + H(+) + NADH => beta-D-galacturonate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381608", "l": "cAMP activates EPAC2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31553", "l": "15-cis-4,4'-diapophytoene + diphosphate => presqualene diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018655", "l": "2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "68.763737436043385", "identifiers": [{"i": "GO:0016667", "l": "oxidoreductase activity, acting on a sulfur group of donors"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12596", "l": "a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16483", "l": "3 H(+) + nicotianamine + 3 S-methyl-5'-thioadenosine => 3 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22755", "l": "A + H2O + uracil <=> AH2 + barbiturate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031734", "l": "CCR9 chemokine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668467", "l": "2xTNFR2 binds TNFA trimer:TNFR2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31485", "l": "H(+) + soyasapogenol E 3-O-beta-D-glucuronate + UDP => soyasapogenol E + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18073", "l": "(S)-dihydroorotate + A = AH2 + orotate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50423", "l": "L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein] <=> H(+) + N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49253", "l": "D-fructose(out) + N(pros)-phospho-L-histidyl-[protein] => D-fructose 1-phosphate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429441", "l": "SYK activation by SRC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2106625", "l": "Duplex siRNA is loaded into Argonaute (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810076", "l": "DDO oxidizes D-Asp to OA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626953", "l": "TNF-alpha:TNFR1 binds DENN/MADD (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25661", "l": "(R)-pulegone + O2 + reduced [NADPH--hemoprotein reductase] <=> (R)-menthofuran + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390886", "l": "HRH4 binds Hist (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48178", "l": "(2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein] => decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14528", "l": "A + beta-cyclopiazonate <=> AH2 + alpha-cyclopiazonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46490", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852200", "l": "Inactivation of LCK by PTPN22 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814088", "l": "SYS1 binds AcM-ARFRP1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9692809", "l": "CDC42 binds effectors at the ER membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24894", "l": "5-hydroxyxanthotoxin + S-adenosyl-L-methionine = isopimpinellin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45484", "l": "H(+) + pyruvate = acetaldehyde + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11365", "l": "ATP + H2O + pyruvate => AMP + 2 H(+) + phosphate + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728729", "l": "TAS1R2:TAS1R3:sweet compound:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding TAS1R2:TAS1R3:sweet compound, GNAT3:GTP, and GNB1,3:GNG13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33867", "l": "(S)-2-ureidoglycine + glyoxylate = glycine + N-carbamoyl-2-oxoglycine"}, {"i": "EC:2.6.1.112", "l": "\"(S)-ureidoglycine--glyoxylate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168400", "l": "iE-DAP elicits a NOD1 response (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418456", "l": "cGMP is degraded by PDEs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16831", "l": "a carboxylate + H(+) + H2O2 => an aldehyde + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40267", "l": "(3S)-hydroxyhexadecanedioyl-CoA + NAD(+) = 3-oxohexadecanedioyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4411373", "l": "NLK translocates to nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003849", "l": "3-deoxy-7-phosphoheptulonate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58101", "l": "1-(15Z-tetracosenoyl)-glycerol + H2O => (15Z)-tetracosenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21787", "l": "H2O + L-ascorbate + O2 <=> 2 H(+) + L-threonate + oxalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1358791", "l": "Phosphorylation of USP8 by P-AKT (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56733", "l": "4,4-dihydroxy-all-trans-beta-carotene => echinenone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213017", "l": "Auto-ubiquitination of TRAF3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40357", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928576", "l": "RHOA:GTP binds ROCK, activating it (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047511", "l": "(S)-methylmalonyl-CoA hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65260", "l": "verruculide C epoxide = 3-hydroxypentacecilide A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52753", "l": "H2O + isomaltose => beta-D-glucose + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45334", "l": "7,8-dihydroxanthopterin + formate + glycolaldehyde + H(+) => 7,8-dihydroneopterin + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158832", "l": "The acetyl group from acetyl-CoA is transferred to the NAT2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61725", "l": "a D-glucoside + NAD(+) => a 3-dehydro-D-glucoside + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65645", "l": "(4R)-hydroxysphing-(8E)-enine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8E)-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700142", "l": "Active ALK binds FRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687088", "l": "PKA phosphorylates MAPKAPK5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047817", "l": "D-arginase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035516", "l": "oxidative DNA demethylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11032", "l": "(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate + H(+)"}, {"i": "EC:5.5.1.7", "l": "\"Chloromuconate cycloisomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54614", "l": "2-hydroxy-3-methylbutanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methylbutanoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51269", "l": "norbelladine + S-adenosyl-L-methionine => 4'-O-methylnorbelladine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37240", "l": "2',3'-cyclic UMP + H2O => H(+) + uridine 2'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32677", "l": "alpha-D-glucose + beta-D-glucose => alpha,alpha-trehalose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16284", "l": "ATP + dihydrostreptomycin 6-phosphate <=> ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40112", "l": "butanoyl-CoA + H2O => butanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41569", "l": "aclacinomycin T + dTDP-2-deoxy-beta-L-fucose => aclacinomycin S + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23585", "l": "7,8-dihydropteroate + ATP + L-glutamate => 7,8-dihydrofolate + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086083", "l": "cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43302", "l": "H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-glycoloylneuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP => alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64537", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672957", "l": "PP2A dephosphorylates KSR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11773", "l": "6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+) => 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.75", "l": "\"Very-long-chain acyl-lipid omega-9 desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45921", "l": "16-hydroxyhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46384", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 24S,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44930", "l": "(R)-trihomocitrate + CoA + H(+) => 2-oxoheptanedioate + acetyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814678", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57040", "l": "aldehydo-D-apiose = D-apiofuranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34334", "l": "H(+) + indole-3-pyruvate + NADPH + O2 <=> (indol-3-yl)acetate + CO2 + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102837", "l": "1-18:2-2-16:1-monogalactosyldiacylglycerol desaturase activity"}, {"i": "MetaCyc:RXN-8297"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24242", "l": "adenosine 5'-phosphosulfate + AH2 => A + AMP + 2 H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20425", "l": "2-oxoglutarate + ATP + hydrogencarbonate = (S)-oxalosuccinate + ADP + H(+) + phosphate"}, {"i": "EC:6.4.1.7", "l": "\"2-oxoglutarate carboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42446", "l": "H(+) + iminosuccinate + NADPH => L-aspartate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432010", "l": "Aquaporin-1 passively transports water into cell (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66774", "l": "ADP + H(+) + phosphate + uroporphyrin I(out) => ATP + H2O + uroporphyrin I(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693540", "l": "MRN activates ATM (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27404", "l": "2-hydroxychromene-2-carboxylate <=> (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.96"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382061", "l": "Extracellular processing of novel PDGFs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426223", "l": "Cation influx mediated by TRPC3/6/7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "81.790986234327661", "identifiers": [{"i": "GO:0015036", "l": "disulfide oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25518", "l": "CoA + H(+) + O-acyltropine => an acyl-CoA + tropine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166387", "l": "The FA anion diffuses away laterally from UCP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66257", "l": "ATP + H(+) + IC-asc-C7 => diphosphate + IC-asc-C7-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73596", "l": "dCMP + H2O => dUMP + NH4+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-947535", "l": "Cyclisation of GTP to precursor Z (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17417", "l": "ATP + N-acetyl-D-glucosamine = ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate"}, {"i": "EC:2.7.1.59", "l": "\"N-acetylglucosamine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848339", "l": "PNPLA5 hydrolyzes TAG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418662", "l": "Src activation following P2Y purinoceptor activation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798743", "l": "Exocytosis of secretory granule membrane proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16229", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate"}, {"i": "EC:2.7.7.41", "l": "\"Phosphatidate cytidylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015182", "l": "L-asparagine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209960", "l": "Diiodinated tyrosine can be deiodinated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16824", "l": "6-phospho-D-gluconate + NAD(+) <=> 6-phospho-2-dehydro-D-gluconate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5632677", "l": "PTCH is internalized (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607756", "l": "TRAF6 oligomer autoubiquitinates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58767", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphate + H(+) + NADPH <=> 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5622129", "l": "FABP5 binds atRA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8963864", "l": "CUBN dissociates from 25(OH)D (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5138459", "l": "WNT5A:FZD4 is endocytosed (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11675", "l": "chorismate + L-glutamine <=> 4-amino-4-deoxychorismate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58499", "l": "choline + H(+) + NADH + O2 <=> glycolaldehyde + H2O + NAD(+) + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10953", "l": "(E)-sinapoyl-CoA + hydroxymalonate => (E)-sinapoyltartronate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12548", "l": "2-cis,4-trans-xanthoxin + NAD(+) = 2-cis-(+)-abscisic aldehyde + H(+) + NADH"}, {"i": "EC:1.1.1.288", "l": "\"Xanthoxin dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696268", "l": "RND3 binds effectors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043780", "l": "cobalt-precorrin-5B C1-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990534", "l": "thermospermine oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32615", "l": "(6E)-8-oxogeraniol + NADP(+) = (6E)-8-oxogeranial + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114684", "l": "Phosphorylation of Syntaxin-4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450488", "l": "BRF1 Complex recruits RNA degradation activities (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54022", "l": "CoA + H(+) + N(6)-propanoyl-L-lysyl-[protein] => L-lysyl-[protein] + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940561", "l": "MMP7 cleaves OPTC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26523", "l": "(2S,3S)-2-methylcitrate => 2-methyl-trans-aconitate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218906", "l": "RIPK3 phosphorylates MLKL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12349", "l": "(S)-muconolactone => (4,5-dihydro-5-oxofuran-2-yl)-acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204824", "l": "Interaction of Tie2 and Ang4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16559", "l": "2-aminomuconate 6-semialdehyde + CO2 => 2-amino-3-carboxymuconate 6-semialdehyde + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662747", "l": "iRHOM2 transports ADAM17 from ER to the Golgi-network (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45073", "l": "(9Z)-octadecenoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] => (9Z)-18-hydroxyoctadecenoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25194", "l": "(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) => 3-methylcatechol + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57839", "l": "H2O + O2 + thermospermine <=> 3-aminopropanal + H2O2 + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33976", "l": "DIMBOA beta-D-glucoside + H2O => D-glucose + DIMBOA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30823", "l": "UDP-N-acetyl-alpha-D-glucosamine = H2O + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose"}, {"i": "EC:4.2.1.135", "l": "\"UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14418", "l": "acetyl phosphate + L-lysine => H(+) + N(6)-acetyl-L-lysine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2152276", "l": "Secretion of transmembrane collagens (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44827", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol <=> a 1,2-diacylglycerol + a monoacyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018631", "l": "phenylacetate hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42767", "l": "formate + 2 H(+) + oxidized coenzyme F420-(gamma-Glu)(n) <=> CO2 + reduced coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14171", "l": "ADP + glutaryl-CoA + phosphate => ATP + CoA + glutarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382057", "l": "Release of novel PDGFs as latent factors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449087", "l": "CD4 binds Interleukin-16 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.109", "l": "\"Matriptase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034829", "l": "2-hydroxydec-2,4-diene-1,10-dioate hydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40822", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-997237", "l": "SH2B proteins bind JAK2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.3", "l": "\"Exodeoxyribonuclease (lambda-induced)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672969", "l": "Phosphorylation of RAF (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015328", "l": "cystine secondary active transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23280", "l": "acetyl-CoA + cysteamine = CoA + S-acetylcysteamine"}, {"i": "EC:2.3.1.11", "l": "\"Thioethanolamine S-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66594", "l": "(DNA)-3'-(deoxyribonucleoside 5'-phosphate)-(2,3-dehydro-2,3-deoxyribose 5'-phosphate) + H(+) + phospho-5'-(DNA) => (DNA)-(deoxyribonucleoside 5'-phosphate)-(deoxyribose 5'-phosphate)-(deoxyribonucleoside 5'-phosphate)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44321", "l": "1-decanoylglycerol + H2O => decanoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042124", "l": "1,3-beta-glucanosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809140", "l": "IL35 binds IL-12RB2:IL6ST receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53802", "l": "lithocholate + ursodeoxycholoyl-CoA => lithocholoyl-CoA + ursodeoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54381", "l": "(2E,6E)-farnesyl diphosphate + H2O => 5-hydroxy-alpha-gurjunene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686578", "l": "Activated ATM phosphorylates ABL1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592436", "l": "Initial activation of proMMP9 by MMPs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36115", "l": "gibberellin A3 + S-adenosyl-L-methionine = O-methyl gibberellin A3 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043723", "l": "2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity"}, {"i": "MetaCyc:RXN-10058"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38955", "l": "an N-acylsphing-4-enine 1-phosphate(in) = an N-acylsphing-4-enine 1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000095", "l": "S-adenosyl-L-methionine transmembrane transporter activity"}, {"i": "REACT:R-HSA-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034579", "l": "(1-methylpentyl)succinate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022911", "l": "CSPG is secreted (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.267", "l": "\"Flavonoid 3',5'-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58776", "l": "NADP(+) + pyridine 3-methanol = H(+) + NADPH + pyridine-3-carbaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37503", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33769", "l": "a (2E)-enoyl-CoA + H2O => a 3-hydroxy-fatty acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62575", "l": "H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteinylglycine <=> glycine + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62036", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444476", "l": "FPRL2 receptor binds a wide range of ligands (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52859", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] <=> (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44154", "l": "myo-inositol + phosphate => 1D-myo-inositol 2-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12132", "l": "ATP + Cd(2+)(in) + H2O = ADP + Cd(2+)(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046409", "l": "p-coumarate 3-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19701", "l": "a flavonol 3-O-glycoside + UDP-alpha-D-xylose = a flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside] + H(+) + UDP"}, {"i": "EC:2.4.2.35", "l": "\"Flavonol-3-O-glycoside xylosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58830", "l": "9R,10R-dihydroxyoctadecanoate => (9S,10R)-epoxy-octadecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050018", "l": "L-amino-acid dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010646", "l": "AKAP5 recruits PKC to ROBO3.1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10082", "l": "1,3,5-trihydroxybenzene + NADPH => dihydrophloroglucinol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33709", "l": "ADP + H(+) + O-phospho-L-threonine => ATP + L-threonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34410", "l": "3 ATP <=> 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14212", "l": "alpha-D-galactose 1-phosphate + H(+) + UTP <=> diphosphate + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39153", "l": "(3R)-hydroxyoctadecanoyl-CoA + NADP(+) => 3-oxooctadecanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28662", "l": "beta-lactose + H2O <=> beta-D-galactose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15251", "l": "1-O-galloyl-beta-D-glucose + UDP => 3,4,5-trihydroxybenzoate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29330", "l": "(S)-malate(in) + succinate(out) <=> (S)-malate(out) + succinate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44322", "l": "decanoate + glycerol + H(+) => 1-decanoylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33750", "l": "a 1-acyl-sn-glycerol + ATP <=> a 1-acyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444859", "l": "Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939205", "l": "ESTG translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051779", "l": "gibberellin 12-aldehyde oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029473", "l": "Branching and elongation of mother and daughter filaments (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668545", "l": "NIK autophosphorylates on T559 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22248", "l": "7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) = 7,8-dihydroxykynurenate + H(+) + NADH"}, {"i": "EC:1.3.1.18", "l": "\"Kynurenate-7,8-dihydrodiol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606163", "l": "p-SYK and LYN phosphorylate BTK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985594", "l": "MYO9B inactivates RHOA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20485", "l": "(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-cheilanthifoline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.19.65", "l": "\"(S)-cheilanthifoline synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111970", "l": "PKC phosphorylates GRK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358791", "l": "Phosphorylation of USP8 by P-AKT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50016", "l": "H2O + octanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + octanoyl-4'-phosphopantetheine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48682", "l": "a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH => a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31650", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199112", "l": "CRTAM binds to NECL2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166214", "l": "FA anion flip-flops to the opposite surface (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987223", "l": "IL10RB binds TYK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21255", "l": "(S)-2-hydroxyglutarate + A <=> 2-oxoglutarate + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13858", "l": "dolichyl beta-D-glucosyl phosphate + H2O => D-glucose + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49901", "l": "5,10-dihydrophenazine-1,6-dicarboxylate + O2 => H2O2 + phenazine-1,6-dicarboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47115", "l": "chenodeoxycholate + glycine <=> glycochenodeoxycholate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33091", "l": "1,4-dihydroxy-6-naphthoate + all-trans-octaprenyl diphosphate + H(+) = 2-demethylmenaquinol-8 + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388830", "l": "PI3K binds ICOS (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27773", "l": "3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49848", "l": "(-)-dehydrodiconiferyl acid ketone + a quinone + H2O = (-)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.31", "l": "\"DNA nucleotidylexotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39603", "l": "(3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA = (2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062081", "l": "activating MHC class Ib receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204850", "l": "Interaction of Tie2 and Dok-2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45549", "l": "[R-phycocyanin alpha-subunit]-Cys(84)-phycourobilin => (2R,3E)-phycoerythrobilin + apo-[R-phycocyanin alpha-subunit]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11573", "l": "FAD + H(+) + H2O + lithocholate => chenodeoxycholate + FADH2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004252", "l": "serine-type endopeptidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060241", "l": "lysozyme inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28738", "l": "H(+)(in) + spermidine(out) <=> H(+)(out) + spermidine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000263", "l": "TCII:Cbl is degraded to release Cbl (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5662613", "l": "MT3 exchanges zinc for copper (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64160", "l": "ATP + glycyl-[methyl-coenzyme M reductase] + hydrogen sulfide = ADP + phosphate + thioglycyl-[methyl-coenzyme M reductase]"}, {"i": "EC:6.2.2.1", "l": "\"Thioglycine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21128", "l": "5alpha-cholesta-8,24-dien-3beta-ol + S-adenosyl-L-methionine = 24-methylene-5alpha-cholest-8-en-3beta-ol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689649", "l": "BAP1 binds BRCA1:BARD1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417825", "l": "P2Y11 receptor can bind to ATP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68960", "l": "DNA polymerase epsilon binds at the origin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21922", "l": "Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018846", "l": "styrene-oxide isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39485", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+) => 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17787", "l": "4-aminobutanoate + CO2 => H(+) + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60513", "l": "a guanosine in miRNA + S-adenosyl-L-methionine => an N(7)-methylguanosine in miRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237129", "l": "Acireductone is created (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928604", "l": "SFKs phosphorylate VAV2,3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55050", "l": "(3E,5Z)-dodecadienoate + CoA + H(+) => (3E,5Z)-dodecadienoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249378", "l": "STING recruits TBK1 and STAT6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015426", "l": "ATPase-coupled polar amino acid-transporter activity"}, {"i": "RHEA:14673", "l": "a polar amino acid(out) + ATP + H2O = a polar amino acid(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72139", "l": "Formation of the active Spliceosomal C (B*) complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37263", "l": "ATP + H2O + L-alanyl-L-aspartate(out) = ADP + H(+) + L-alanyl-L-aspartate(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209313", "l": "Autocleavage of HH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52547", "l": "D-erythronate + NAD(+) <=> 2-dehydro-D-erythronate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3095901", "l": "ABCC1 transports cytosolic Cbl to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68849", "l": "Mcm2-7 associates with the Cdt1:CDC6:ORC:origin complex, forming the pre-replicative complex (preRC) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45984", "l": "3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH + O2 = 9alpha-hydroxy-3-oxochola-1,4-dien-22-oyl-CoA + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63292", "l": "N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1248) in human 18S rRNA + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37243", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1640164", "l": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54704", "l": "N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034018", "l": "ascopyrone tautomerase activity"}, {"i": "RHEA:22568", "l": "ascopyrone M = ascopyrone P"}, {"i": "EC:5.3.2.7", "l": "\"Ascopyrone tautomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428888", "l": "Phosphorylation of ROBO1 by ABL kinase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16369", "l": "(R)-lactate + NAD(+) = H(+) + NADH + pyruvate"}, {"i": "EC:1.1.1.28", "l": "\"D-lactate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30681", "l": "2 beta-D-glucose => D-cellobiose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047104", "l": "hexadecanal dehydrogenase (acylating) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37109", "l": "N(7)-methylguanosine + phosphate => H2O + N(7)-methyl-GMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4332359", "l": "Active calmodulin binds CAMK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50905", "l": "L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707586", "l": "FeHM oxidises LDL,HDL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59579", "l": "anserine + H2O <=> beta-alanine + N(pros)-methyl-L-histidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174931", "l": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191402", "l": "Reduction of presqualene diphosphate to form squalene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2129362", "l": "Fibrillin microfibril assembly (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047833", "l": "D-sorbitol dehydrogenase (acceptor) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27430", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O => a 1,2-diacyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183067", "l": "Localization of CBL:GRB2 to the membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13631", "l": "(R)-carvone + H(+) + NADPH => (1S,5R)-carveol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691150", "l": "TFR2 dimer binds 2xholoTF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714481", "l": "RAC2 binds effectors at the ER membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213236", "l": "TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36617", "l": "CoA + H(+) + N-(2-hydroxyoctadecanoyl)-sphinganine => 2-hydroxyoctadecanoyl-CoA + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791348", "l": "TP53 stimulates APAF1 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10428", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}, {"i": "EC:1.13.11.31", "l": "\"Arachidonate 12-lipoxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14818", "l": "4-maleylacetoacetate => 4-fumarylacetoacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0034603", "l": "pyruvate dehydrogenase [NAD(P)+] activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61856", "l": "dehydroprobetaenone I + 3 H(+) + 3 NADPH + 3 O2 = betaenone C + 3 H2O + 3 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445699", "l": "ATP Hydrolysis By Myosin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68637", "l": "CDC6 protein is synthesized under the control of E2F transcription factors (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71590", "l": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668545", "l": "NIK autophosphorylates on T559 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674018", "l": "BRAP binds RAS:GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37013", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50075", "l": "ATP + H2O + tauroursodeoxycholate(in) <=> ADP + H(+) + phosphate + tauroursodeoxycholate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34218", "l": "4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+) <=> 4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14940", "l": "all-trans-antheraxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-violaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60264", "l": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.364", "l": "\"[Histone H3]-lysine(4) N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14451", "l": "3,8-divinyl chlorophyllide a + H(+) + NADPH => chlorophyllide a + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39084", "l": "3-oxododecanedioyl-CoA + CoA => acetyl-CoA + decanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132264", "l": "Formation of alternate C5 convertase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28424", "l": "2-hydroxy-2-methylbutanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (1E,2S)-2-methylbutanal oxime + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41099", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10141", "l": "NADP(+) + prostaglandin F2alpha => H(+) + NADPH + prostaglandin D2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43728", "l": "methyl (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + juvenile hormone III + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.127", "l": "\"Methyl farnesoate epoxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34696", "l": "(2E,6E)-farnesyl diphosphate => Delta(6)-protoilludene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66554", "l": "5-serotonyl-L-glutamyl-[protein] + NH4(+) => L-glutaminyl-[protein] + serotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30770", "l": "D-glucurono-3,6-lactone + H2O <=> D-glucuronate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62723", "l": "3 H(+) + 3 NADPH + 3 O2 + probetaenone I <=> betaenone B + 3 H2O + 3 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63173", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA => (25R)-3-oxocholest-4-en-26-oyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60961", "l": "18-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose => (9Z)-18-hydroxyoctadec-9-enoate 18-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034610", "l": "oligodeoxyribonucleotidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098640", "l": "integrin binding involved in cell-matrix adhesion"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23572", "l": "3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 3 CO2 + 4 CoA + phlorisovalerophenone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797554", "l": "ABP1 binds SHANK proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51452", "l": "O2 + reduced [NADPH--hemoprotein reductase] + ursodeoxycholate = beta-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1454928", "l": "ABCG4 may mediate cholesterol efflux (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8987214", "l": "p-STAT3 dimerizes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190258", "l": "FGFR2c binds to FGF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54933", "l": "(3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] => (2E,9Z)-hexadecadienoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102084", "l": "L-dopa O-methyltransferase activity"}, {"i": "MetaCyc:RXN-10870"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110218", "l": "Cleavage of uracil by TDG glycosylase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13499", "l": "6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+) => 5-dehydro-2-deoxy-D-gluconate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25575", "l": "geranylgeranyl diphosphate + 2 H2O <=> diphosphate + sclareol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52106", "l": "an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+) => a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408529", "l": "Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62350", "l": "H2O + NADP(+) + notoamide C => H(+) + NADPH + notoamide E + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57809", "l": "1-chloro-3-nitrobenzene + NADH + O2 => 3-chlorocatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045340", "l": "mercury ion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177479", "l": "Axonal transport of NGF:Trk complexes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17727", "l": "2-methyl-cis-aconitate + H2O => (2S,3S)-2-methylcitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44020", "l": "H2O + NAD(+) + octadecanal = 2 H(+) + NADH + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4411373", "l": "NLK translocates to nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948775", "l": "MKRN1 polyubiquitinates PTEN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8963851", "l": "VD3 dissociates from GC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "76.125169645393314", "identifiers": [{"i": "GO:0019104", "l": "DNA N-glycosylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54693", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (13E)-labda-7,13-dien-15-yl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203611", "l": "N-myristoylation of eNOS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50380", "l": "3 H(+) + 3 malonyl-CoA = 1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA"}, {"i": "EC:2.3.1.253", "l": "\"Phloroglucinol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36039", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NAD(+) = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52856", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine"}, {"i": "EC:1.5.8.4", "l": "\"Dimethylglycine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-419490", "l": "Binding of ATP to P2X receptors (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37895", "l": "H2O + protodioscin = 26-deglucoprotodioscin + D-glucose"}, {"i": "EC:3.2.1.186", "l": "\"Protodioscin 26-O-beta-D-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446391", "l": "Formation of the PINCH-ILK-parvin complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34442", "l": "2,3-didehydroadipyl-CoA + acetyl-CoA <=> 3-oxo-5,6-didehydrosuberyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40298", "l": "ATP + CoA + hexadecanedioate <=> AMP + diphosphate + hexadecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48278", "l": "a beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine => H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.11"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055054", "l": "fructose:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58371", "l": "(2E,6Z)-nona-2,6-dien-1-ol + NADP(+) <=> (2E,6Z)-nona-2,6-dienal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9609310", "l": "β-blockers bind ADRB1,2,3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187895", "l": "Engulfed CpG DNA binds to endosomal C-ter TLR9 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31303", "l": "a reduced flavin + NAD(+) = an oxidized flavin + 2 H(+) + NADH"}, {"i": "EC:1.5.1.36", "l": "\"Flavin reductase (NADH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30100", "l": "1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H(+) => 2-demethylmenaquinol-8 + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938815", "l": "RNF152 polyubiquitinates RRAGA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687455", "l": "HSV1 RIR1 binds RIPK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52596", "l": "lithocholoyl-CoA + NAD(+) = 3-oxocholan-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66638", "l": "(-)-alpha-acorenol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788622", "l": "p-Y-STATs dimerize (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165179", "l": "Formation of TSC1:TSC2 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13959", "l": "6 H(+) + 2 hydrogen sulfide + 2 sulfite => 4 H2O + O2 + 4 sulfur"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211874", "l": "CYP2S1 4-hydroxylates atRA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47361", "l": "decanoate ester + H2O => an aliphatic alcohol + decanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156699", "l": "Inactivation of Wee1 kinase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655830", "l": "Expression of Acetyl CoA Carboxylase 2 (ACACB, ACC2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70475", "l": "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20102", "l": "a long-chain fatty acid + ATP + L-cysteinyl-[protein] => AMP + diphosphate + S-(long-chain fatty acyl)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9008043", "l": "MAPK8 phosphorylation (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46319", "l": "GDP-N,N'-diacetylbacillosamine + H2O <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5674385", "l": "p-T,Y MAPKs dimerize (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18700", "l": "3-(4-hydroxyphenyl)pyruvate + H(+) <=> (4-hydroxyphenyl)acetaldehyde + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29390", "l": "CTP + H2O <=> CDP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29828", "l": "Mg(2+)(in) => Mg(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2512800", "l": "SCARB1:ligand is endocytosed (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50522", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0031784", "l": "melatonin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112395", "l": "Abortive termination of elongation after arrest (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674563", "l": "CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61207", "l": "L-arginyl-[protein] + L-cysteinyl-[protein] + methylglyoxal <=> H(+) + 2 H2O + N(5)-[4-(S-L-cysteinyl-[protein])-5-methyl-1H-imidazol-2-yl]-L-ornithinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19685", "l": "(E)-feruloyl-CoA + tyramine = CoA + H(+) + N-[(E)-feruloyl]tyramine"}, {"i": "EC:2.3.1.110", "l": "\"Tyramine N-feruloyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676593", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25869", "l": "H2O + N(1),N(12)-diacetylspermine + O2 => 3-acetamidopropanal + H2O2 + N(1)-acetylspermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62013", "l": "cytidine(2499) in 23S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(2499) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33014", "l": "(+)-artemisinic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-artemisinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202478", "l": "Interaction and oligomerization of MALT1 to Bcl10 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186773", "l": "PDGF dimer binds two receptors simultaneously (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43085", "l": "cytidine(34) in tRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49630", "l": "3,5-dimethylorsellinate + 3 CO2 + 4 CoA + 2 S-adenosyl-L-homocysteine => acetyl-CoA + 3 malonyl-CoA + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11707", "l": "2 H(+) + N-(carboxyaminomethyl)urea <=> CO2 + N-(aminomethyl)urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61507", "l": "pelargonidin + UDP-alpha-D-glucose <=> pelargonidin 3-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25741", "l": "H(+) + H2O + N,N-dihydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617182", "l": "PRKACA phosphorylates PLN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034935", "l": "tetrachlorobenzene dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173631", "l": "Activation of C1s (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0033931", "l": "endogalactosaminidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8939204", "l": "ESTG binds ESR1:chaperone complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54743", "l": "9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25439", "l": "(2E,6E)-farnesyl diphosphate <=> (E,R)-alpha-bisabolene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47849", "l": "2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) => CO2 + diphosphate + thiamine phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015649", "l": "2-keto-3-deoxygluconate:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "80.155824608458104", "identifiers": [{"i": "GO:0098631", "l": "cell adhesion mediator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9649735", "l": "Intrinsic nucleotide exchange on RAS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392133", "l": "G alpha (z) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56959", "l": "ITP + pyruvate <=> H(+) + IDP + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28851", "l": "melibiose(in) + Na(+)(in) = melibiose(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69068", "l": "RFC dissociates after sliding clamp formation (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112342", "l": "Inactivation of MAP2K1 by CDK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9656947", "l": "OGG1beta translocates to mitochondria (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35639", "l": "(4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate"}, {"i": "EC:4.1.3.42", "l": "\"(4S)-4-hydroxy-2-oxoglutarate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982017", "l": "Active G alpha (q) binds RGS proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48206", "l": "(2E)-pentadecenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + pentadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40167", "l": "hexadecanoyl-CoA + O2 = (2E)-hexadecenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58292", "l": "25-substituted-cholesterol + beta-D-glucosyl-N-dodecanoylsphing-4E-enine = 25-substituted-cholesteryl beta-D-glucoside + N-dodecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424486", "l": "Phosphorylation and activation of VAV2/VAV3 by SYK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350578", "l": "NQO1 interaction with ODC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30472", "l": "(2Z,6Z)-farnesyl diphosphate => (-)-endo-alpha-bergamotene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19155", "l": "7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone + H(+) + UDP => apigenin 7-O-beta-D-glucoside + UDP-alpha-D-apiose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19165", "l": "a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose = 1,2-diacyl-3-O-[alpha-D-glucosyl-(1-> 2)-alpha-D-glucosyl]-sn-glycerol + H(+) + UDP"}, {"i": "EC:2.4.1.208", "l": "\"Diglucosyl diacylglycerol synthase (1,2-linking)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47313", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] => 15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57298", "l": "a 2'-deoxyguanosine in DNA + glycolate + H(+) => an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32094", "l": "3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine <=> dTDP + erythromycin D + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5138432", "l": "DVL2 is phosphorylated by PKC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989760", "l": "Expression of HMGCS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60311", "l": "L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64749", "l": "H2O + S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine => 2-methyl-3-sulfanylbutan-1-ol + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018742", "l": "epoxide hydrolase B activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58940", "l": "(1R,2R,3R)-prephytoene diphosphate + H(+) + NADH = all-trans-lycopaoctaene + diphosphate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018484", "l": "4-hydroxybenzaldehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32179", "l": "(S)-2,3-dihydrodipicolinate + NAD(+) = dipicolinate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679045", "l": "C-ter TLR9 dimer binds HCQ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10468", "l": "D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O"}, {"i": "EC:4.1.2.9", "l": "\"Phosphoketolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951966", "l": "EP300 acetylates RUNX3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25937", "l": "8-methylquinoline + A + H2O => 8-methylquinolin-2(1H)-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12426", "l": "NH4(+) + oxaloacetate => (3S)-3-hydroxy-L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32636", "l": "linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (6E)-8-oxolinalool + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54452", "l": "a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66230", "l": "asc-DeltaC13-CoA + H2O2 => asc-C13-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39753", "l": "11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61062", "l": "a neolactoside nLc4Cer + H(+) + UDP => beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15622", "l": "an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508292", "l": "SYK binds IL2RB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9646468", "l": "mTORC1 binds RHEB:GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-888577", "l": "Synthesis of GABA by GAD2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59319", "l": "D-cellobiose + O2 <=> D-cellobiono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782224", "l": "3' incision by ERCC5 (XPG) in TC-NER (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32505", "l": "(6E)-8-hydroxylinalool + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => linalool + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35227", "l": "H(+)(out) + rifampicin(in) = H(+)(in) + rifampicin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57030", "l": "(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FAD + H(+) => FADH2 + N-methylnicotinate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56678", "l": "(E)-feruloyl-CoA + H(+) + NADPH => dihydroferuloyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35887", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139906", "l": "Activation of BAD by calcineurin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32780", "l": "ATP + Co(2+)(out) + H2O => ADP + Co(2+)(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10576", "l": "CTP + H(+) + N-methylethanolamine phosphate = CDP-N-methylethanolamine + diphosphate"}, {"i": "EC:2.7.7.57", "l": "\"N-methylphosphoethanolamine cytidylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848339", "l": "PNPLA5 hydrolyzes TAG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433940", "l": "Association of LBP with bacterial LPS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15989", "l": "(R)-mevalonate + CoA + 2 NADP(+) = (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH"}, {"i": "EC:1.1.1.34", "l": "\"Hydroxymethylglutaryl-CoA reductase (NADPH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1878002", "l": "XYLTs transfer Xyl to core protein (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5633051", "l": "EFCAB7:IQCE binds EVC2:EVC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46676", "l": "(4R)-hydroxy-(6R)-2,2,6-trimethylcyclohexanone + NAD(+) = (6R)-2,2,6-trimethyl-1,4-cyclohexanedione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69116", "l": "Formation of Okazaki fragments (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047865", "l": "dimethylglycine dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29610", "l": "H2O + NAD(+) + nitrous oxide <=> H(+) + NADH + 2 nitric oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203070", "l": "Association of profilin with monomeric actin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690196", "l": "USP8 deubiquitinates RNF128 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10188", "l": "acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+)"}, {"i": "EC:2.3.3.10", "l": "\"Hydroxymethylglutaryl-CoA synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43265", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA => 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61714", "l": "2 [Fe(III)-cytochrome b5] + H2O + N(delta)-methyl-L-arginine => 2 [Fe(II)-cytochrome b5] + 2 H(+) + N(omega)-hydroxy-N(delta)-methyl-L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9016751", "l": "FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51431", "l": "acetyl-CoA + aminomethylphosphonate <=> 2-N-acetamidomethylphosphonate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389956", "l": "Beta-tubulin:GTP + Cofactor A ->  Beta-tubulin:GTP: Cofactor A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14794", "l": "2-hydroxyadipate + NAD(+) => 2-oxoadipate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903962", "l": "arachidonate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204485", "l": "Basigin binds CyPA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48860", "l": "18-HEPE + O2 = (5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785213", "l": "LIPC dimer binds heparin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46848", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+) = 5alpha-cholest-8-en-3-one + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210837", "l": "HNF6-dependent synthesis of ONECUT3 protein during morphogenesis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199425", "l": "PHLPP dephosphorylates S473 in AKT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811472", "l": "IER3 recruits MAPKs to PP2A-B56-beta,gamma (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31999", "l": "(2E,6E)-farnesyl diphosphate = bicyclogermacrene + diphosphate"}, {"i": "EC:4.2.3.100", "l": "\"Bicyclogermacrene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31718", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 11alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45193", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39711", "l": "O2 + 2 reduced coenzyme F420-(gamma-Glu)(n) = 2 H(+) + 2 H2O + 2 oxidized coenzyme F420-(gamma-Glu)(n)"}, {"i": "EC:1.5.3.22", "l": "\"Coenzyme F420H(2) oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49015", "l": "aurachin C + H(+) + NADH + O2 <=> aurachin C epoxide + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42008", "l": "5alpha-pregnan-20beta-ol-3-one + NAD(+) = 5alpha-pregnane-3,20-dione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004347", "l": "glucose-6-phosphate isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15967", "l": "1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31741", "l": "a 4'-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine => a 4'-hydroxyisoflavone + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46556", "l": "5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + cholesta-5,7-dien-3beta-ol + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55298", "l": "13-cis-retinyl hexadecanoate + CoA => 13-cis-retinol + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37427", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate = a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23238", "l": "H(+) + L-glutamyl-[protein] + methanol => [protein]-L-glutamate 5-O-methyl ester + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25984", "l": "(+)-epi-isozizaene + H(+) + NADPH + O2 = (5R)-albaflavenol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25156", "l": "(R)-4'-phosphopantothenate + ATP + L-cysteine = AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine"}, {"i": "EC:6.3.2.51", "l": "\"Phosphopantothenate--cysteine ligase (ATP)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351341", "l": "Exocytosis of Proactivator polypeptide (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20012", "l": "2-hydroxy-2-methylpropanenitrile + UDP-alpha-D-glucose <=> H(+) + linamarin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30027", "l": "D-glyceraldehyde + H(+) + NADH = glycerol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13654", "l": "[6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose => [6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032767", "l": "copper-dependent protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.43", "l": "\"Lipid A phosphoethanolamine transferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990043", "l": "5' deoxyribonuclease (pyrimidine dimer) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901611", "l": "phosphatidylglycerol binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33317", "l": "1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434700", "l": "STIM1 activation of CRAC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27460", "l": "3-iodo-L-tyrosine + iodide + NADP(+) <=> 3,5-diiodo-L-tyrosine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29637", "l": "alpha-D-glucose + alpha-maltotetraose => alpha-maltopentaose + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034839", "l": "menth-2-enone hydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37120", "l": "7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine => 2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199456", "l": "PTEN dephosphorylates PIP3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40987", "l": "EDTA + 2 FMNH2 + 2 O2 = ethylenediaminediacetate + 2 FMN + 2 glyoxylate + 3 H(+) + 2 H2O"}, {"i": "EC:1.14.14.33", "l": "\"Ethylenediaminetetraacetate monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624800", "l": "CDK1 phosphorylates LBR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65471", "l": "1-propanol + acetyl-CoA <=> CoA + propyl acetate"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0015137", "l": "citrate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36559", "l": "A + cis-4-hydroxy-D-proline = 4-hydroxy-1-pyrroline-2-carboxylate + AH2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5622134", "l": "CRABP1 binds atRA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66897", "l": "4 O2 + ophiobolin F + 4 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 6 H2O + ophiobolin C + 4 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19196", "l": "A + all-trans-13,14-dihydroretinol <=> AH2 + all-trans-retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987214", "l": "p-STAT3 dimerizes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39459", "l": "(7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4093327", "l": "EPHA binds TIAM1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9652264", "l": "ERBB2 binds TKIs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374673", "l": "L1 binds RanBPM (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12047", "l": "a triacylglycerol + H2O <=> a diacylglycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47177", "l": "(2R)-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.222", "l": "\"(R)-4-hydroxyphenyllactate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64602", "l": "a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2294574", "l": "Condensin II-mediated condensation of prophase chromosomes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005011", "l": "macrophage colony-stimulating factor receptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0003774", "l": "cytoskeletal motor activity"}, {"i": "REACT:R-HSA-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.248", "l": "\"Cycloisomaltooligosaccharide glucanotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55496", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-cassa-12,15-dien-2beta,3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12085", "l": "D-mannitol + NAD(+) => D-fructose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14776", "l": "2 NADPH + palmatine + S-adenosyl-L-methionine <=> corydaline + 2 NADP(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870461", "l": "RABGGTA and RABGGTB bind (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70667", "l": "1PYR-5COOH spontaneously hydrolyses to L-GluSS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42168", "l": "20alpha-hydroxy-5beta-pregnan-3-one + NADP(+) = 5beta-pregnan-3,20-dione + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12299", "l": "deacetylipecoside + H2O <=> dopamine + secologanin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45587", "l": "3-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "79.682896251205548", "identifiers": [{"i": "GO:0005249", "l": "voltage-gated potassium channel activity"}, {"i": "REACT:R-HSA-1296127", "l": "Activation of voltage gated Potassium channels (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18638", "l": "H2 + NADP(+) => H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10831", "l": "anthranilate + ATP + CoA <=> AMP + anthraniloyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23399", "l": "H2O + phloretin <=> 1,3,5-trihydroxybenzene + H(+) + phloretate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62830", "l": "GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl-8-{[beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52847", "l": "3,4-dihydroxybenzoate + UDP-alpha-D-glucose <=> 1-O-(3,4-dihydroxy-benzoyl)-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25612", "l": "beta-D-allofuranose <=> beta-D-allopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977605", "l": "Factor H displaces Bb (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38940", "l": "dioscin + 2 H2O => diosgenin 3-O-beta-D-glucoside + 2 L-rhamnopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3341277", "l": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783552", "l": "OSM binds LIFR:JAKs,OSMR:JAKs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706336", "l": "Active FLT3 binds to SYK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16818", "l": "6-phospho-D-gluconate + NADP(+) => 6-phospho-2-dehydro-D-gluconate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0050840", "l": "extracellular matrix binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57272", "l": "a 2'-deoxyguanosine in DNA + methylglyoxal = an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174931", "l": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655252", "l": "Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009035", "l": "type I site-specific deoxyribonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62802", "l": "2 H2O + NADP(+) + orlandin => 2 7-demethylsiderin + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14771", "l": "(S)-6-hydroxynicotine + AH2 => (S)-nicotine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51675", "l": "glyoxal + H2O <=> glycolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086216", "l": "Collagen type VII binds integrin alpha2beta1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24604", "l": "7-methylxanthine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + theobromine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944215", "l": "Association of procollagen type XX (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381091", "l": "IRE1 dimer autophosphorylates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55253", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine => 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48348", "l": "a uridine in RNA = a pseudouridine in RNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10279", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) <=> 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696958", "l": "USP44 deubiquitinates CDC20 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54716", "l": "N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63758", "l": "flavokermesate 7-C-beta-D-glucoside + 2 H(+) + UDP => flavokermesate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52918", "l": "16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036374", "l": "glutathione hydrolase activity"}, {"i": "REACT:R-HSA-5602984", "l": "Defective GGT1 does not hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35321", "l": "3-oxoeicosanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687465", "l": "MRN complex binds RBBP8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11145", "l": "GDP-alpha-D-mannose => GDP-beta-L-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45393", "l": "H2O + N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-eicosanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44029", "l": "L-altrarate => 5-dehydro-4-deoxy-D-glucarate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24426", "l": "glutathione disulfide + L-ascorbate => 2 glutathione + L-dehydroascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374919", "l": "Noradrenaline clearance from the synaptic cleft (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174157", "l": "Degradation of multiubiquitinated Cyclin B (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59628", "l": "H2O + N(2)-(4-aminobutanoyl)-L-arginine = 4-aminobutanoate + L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44638", "l": "2,4-dinitrophenol + H(+) + methanol => 2,4-dinitroanisole + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50269", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate => (5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990610", "l": "acetolactate synthase regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381091", "l": "IRE1 dimer autophosphorylates (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050316", "l": "T2-induced deoxynucleotide kinase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001760", "l": "aminocarboxymuconate-semialdehyde decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102253", "l": "neoagarobiose 1,3-alpha-3,6-anhydro-L-galactosidase activity"}, {"i": "MetaCyc:RXN-12426"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30658", "l": "ATP + dUMP <=> ADP + dUDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49038", "l": "(-)-bursehernin + H(+) + S-adenosyl-L-homocysteine => (-)-pluviatolide + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450387", "l": "HuR binds the CRM1 nuclear export machinery (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201622", "l": "Caspase-mediated cleavage of gelsolin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939201", "l": "ESR dimerizes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64861", "l": "(E)-5-hydroxyferuloyl-CoA + S-adenosyl-L-methionine => (E)-sinapoyl-CoA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57734", "l": "AH2 + all-trans-retinol => A + all-trans-7,8-dihydroretinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.35", "l": "\"2-dehydrotetronate isomerase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047359", "l": "1-alkenyl-2-acylglycerol choline phosphotransferase activity"}, {"i": "RHEA:21072"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49467", "l": "2,6-dihydroxybenzoate + H(+) <=> CO2 + resorcinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53950", "l": "ADP + gamma-L-glutamyl-[BtrI ACP] + phosphate => ATP + holo-[BtrI ACP] + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20117", "l": "ATP + L-rhamnulose = ADP + H(+) + L-rhamnulose 1-phosphate"}, {"i": "EC:2.7.1.5", "l": "\"Rhamnulokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404144", "l": "Parenchymal atROL translocates to HSCs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65620", "l": "hexadecanoyl-CoA + sphinga-(4E,8E)-dienine = CoA + H(+) + N-hexadecanoylsphinga-(4E,8E)-dienine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382053", "l": "Translocation of PDGF from ER to Golgi (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675790", "l": "MTORC1 dissociates from ULK complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601887", "l": "PLD6 dimer cleaves primary piRNA transcript to pre-piRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60070", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 4 H2O + 3 NAD(+) => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H(+) + 3 NADH + 3 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15820", "l": "H2O + O2 + pyridoxamine 5'-phosphate <=> H2O2 + NH4(+) + pyridoxal 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482772", "l": "Release of platelet cytosolic components (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120159", "l": "rRNA pseudouridine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74716", "l": "Insulin binds the insulin receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428273", "l": "SPHK1 phosphorylates SPG to S1P (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54260", "l": "2-oxoglutarate + L-asparaginyl-[protein] + O2 = (3S)-3-hydroxy-L-asparaginyl-[protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63483", "l": "NADP(+) + prostaglandin F2alpha <=> 15-oxoprostaglandin F2alpha + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49521", "l": "2-oxoglutarate + N(6)-methyladenosine in mRNA + O2 => adenosine in mRNA + CO2 + formaldehyde + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22797", "l": "ATP + D-hamamelose => ADP + D-hamamelose 2'-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41939", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983153", "l": "E1 mediated ubiquitin activation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44532", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18811", "l": "aminomalonate + pyruvate => L-alanine + oxomalonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202472", "l": "Translocation of TRAF6 to CBM complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694733", "l": "Polyadenylation of SARS-CoV-2 subgenomic mRNAs (plus strand) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198669", "l": "p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10224", "l": "ATP + pyridoxal = ADP + H(+) + pyridoxal 5'-phosphate"}, {"i": "EC:2.7.1.35", "l": "\"Pyridoxal kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33197", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54462", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate => 1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875451", "l": "MET phosphorylates CBL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022859", "l": "dephosphorylation-gated channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29760", "l": "octanoate(in) => octanoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22964", "l": "H(+) + L-ornithine = CO2 + putrescine"}, {"i": "EC:4.1.1.17", "l": "\"Ornithine decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696275", "l": "RND2 binds GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11445", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O => 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388832", "l": "PI3K binds CD28 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389348", "l": "Activation of Rac1 by pVav1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37428", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate => a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390595", "l": "Calcium Binds Troponin-C (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50799", "l": "glutathione + prostaglandin A2 <=> prostaglandin A2-S-(R)-glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23756", "l": "D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H(+) + H2O2"}, {"i": "EC:1.1.3.37", "l": "\"D-arabinono-1,4-lactone oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388831", "l": "Phosphorylation of CD28 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65664", "l": "citrate(out) + 4 Na(+)(out) = citrate(in) + 4 Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050638", "l": "taxadien-5-alpha-ol O-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59457", "l": "NADP(+) + tetradecan-1-ol => H(+) + NADPH + tetradecanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57554", "l": "(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21753", "l": "all-trans-violaxanthin => all-trans-capsorubin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41043", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + octanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-octanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730886", "l": "Phosphorylation of SHC by SYK kinase (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3341277", "l": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6794347", "l": "Homer1,2,3 dimerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37782", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6790038", "l": "Expression of HSP90B1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14304", "l": "4-pyridoxolactone + H2O <=> 4-pyridoxate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097247", "l": "epigallocatechin 3-gallate binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062122", "l": "histone methyltransferase activity (H3-K37 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33440", "l": "glyoxal + H2O + O2 => glyoxylate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41100", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64223", "l": "H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26398", "l": "all-trans-zeaxanthin + 2 O2 => 2 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48149", "l": "ganglioside GT1b (d18:1(4E)/18:0) + H2O => ganglioside GD1b(d18:1(4E)/18:0) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045015", "l": "HDEL sequence binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40019", "l": "ent-copalyl diphosphate + H2O = (-)-ent-copalol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63780", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686338", "l": "SARS-CoV-1 3a binds the lysosomal membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709406", "l": "CO binds to Cytochrome c oxidase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209289", "l": "TAB2 binds to ubiquitinated IAP2:BEN:UEV1A E3 ligase complex and activates TAK1 kinase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433454", "l": "Phosphorylation of GAB2 by SFKs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66816", "l": "2 Na(+)(in) + tetrahydroxoborate(in) = 2 Na(+)(out) + tetrahydroxoborate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473186", "l": "FSTL3 binds Activin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40151", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64704", "l": "diphenylmethanol + NAD(+) = benzophenone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050126", "l": "N-carbamoylputrescine amidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39339", "l": "(9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210290", "l": "Interaction of PECAM-1 and SHIP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40068", "l": "2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O => 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046714", "l": "borate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55315", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878117", "l": "RUNX3 binds ZFHX3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25638", "l": "H2O + NAD(+) + sulfoacetaldehyde => 2 H(+) + NADH + sulfoacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43105", "l": "AH2 + N-acyleicosasphinganine + O2 => A + 2 H2O + N-acyleicosasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43286", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39917", "l": "1-O-alkyl-sn-glycerol + phosphate => 1-O-alkyl-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424486", "l": "Phosphorylation and activation of VAV2/VAV3 by SYK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50605", "l": "acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047975", "l": "guanosine phosphorylase activity"}, {"i": "EC:2.4.2.15", "l": "\"Guanosine phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950731", "l": "CRLF1:IL27 translocates to the extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60878", "l": "a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+) => a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008902", "l": "hydroxymethylpyrimidine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23678", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate => ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15542", "l": "DIMBOA + UDP-alpha-D-glucose => DIMBOA beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050526", "l": "poly(3-hydroxybutyrate) depolymerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204824", "l": "Interaction of Tie2 and Ang4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34803", "l": "2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA = bisdemethoxycurcumin + 2 CO2 + 3 CoA"}, {"i": "EC:2.3.1.211", "l": "\"Bisdemethoxycurcumin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23737", "l": "5-hydroxyisourate + H2O => 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.335", "l": "\"4-amino-anhydrotetracycline N(4)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047122", "l": "quinaldate 4-oxidoreductase activity"}, {"i": "RHEA:16697", "l": "A + H2O + quinaldate = AH2 + kynurenate"}, {"i": "EC:1.3.99.18", "l": "\"Quinaldate 4-oxidoreductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604722", "l": "Activation of proMMP9 by proteases (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50255", "l": "an acyl-CoA + H(+) + malonyl-CoA <=> a 3-oxoacyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43151", "l": "adenosine(9) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11768", "l": "diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate"}, {"i": "EC:2.4.2.18", "l": "\"Anthranilate phosphoribosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35566", "l": "H2O + N-(9Z-hexadecenoyl) ethanolamine <=> (9Z)-hexadecenoate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876446", "l": "p-ULK1 phosphorylates DENND3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65434", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+) => a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29553", "l": "alpha-D-galactose 1-phosphate + 2 H(+) + UMP => H2O + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112396", "l": "Separation of elongating transcript from template (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162657", "l": "Inactivation of Myt1 kinase (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005053", "l": "peroxisome matrix targeting signal-2 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53867", "l": "3alpha,7beta-dihydroxy-12-oxo-5beta-cholan-24-oate + NADP(+) <=> 7,12-dioxo-lithocholate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31072", "l": "(S)-methylmalonate semialdehyde + L-alanine => (S)-3-amino-2-methylpropanoate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46420", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}, {"i": "RHEA:46424", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}, {"i": "EC:1.14.19.44", "l": "\"Acyl-CoA (8-3)-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65012", "l": "decanoyl-AMP + holo-[ACP] = AMP + decanoyl-[ACP] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177930", "l": "GAB1 phosphorylation by EGFR kinase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212352", "l": "Formation of ARC coactivator complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204500", "l": "CyP60 chaperones Basigin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23306", "l": "H(+) + tropate + tropine => atropine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54493", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine => 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990715", "l": "mRNA CDS binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31827", "l": "(2E,6E)-farnesyl diphosphate = (+)-gamma-cadinene + diphosphate"}, {"i": "EC:4.2.3.92", "l": "\"(+)-gamma-cadinene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018826", "l": "RHOT2 hydrolyzes GTP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23952", "l": "H2O + N-(2-phenylethyl)acetamide = 2-phenylethylamine + acetate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102249", "l": "phosphatidylcholine:diacylglycerol cholinephosphotransferase activity"}, {"i": "MetaCyc:RXN-12386"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35687", "l": "NADP(+) + tetradecasphinganine = 3-oxotetradecasphinganine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55861", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061594", "l": "6-deoxy-6-sulfofructose kinase activity"}, {"i": "RHEA:40443", "l": "6-deoxy-6-sulfo-D-fructose + ATP = 6-deoxy-6-sulfo-D-fructose 1-phosphate + ADP + H(+)"}, {"i": "EC:2.7.1.184", "l": "\"Sulfofructose kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174070", "l": "Association of Cdh1 with the APC/C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878056", "l": "RUNX1:CBFB binds EP300 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003878", "l": "ATP citrate synthase activity"}, {"i": "KEGG.REACTION:R00352"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382053", "l": "Translocation of PDGF from ER to Golgi (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54131", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419166", "l": "GEFs activate RhoA,B,C (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65426", "l": "AMP(out) + NAD(+)(in) => AMP(in) + NAD(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36079", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine = a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202291", "l": "Activation of Lck (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62587", "l": "ATP + H2O + L-tyrosine(out) <=> ADP + H(+) + L-tyrosine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48707", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> 12S-HpEPE"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74986", "l": "Elongation of pre-rRNA transcript (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176116", "l": "Recruitment and activation of Chk1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618785", "l": "Calmodulin binds neurogranin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110218", "l": "Cleavage of uracil by TDG glycosylase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30084", "l": "4 Cu(+) + 4 H(+) + O2 => 4 Cu(2+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004754", "l": "saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"}, {"i": "RHEA:12440", "l": "H2O + L-saccharopine + NAD(+) = 2-oxoglutarate + H(+) + L-lysine + NADH"}, {"i": "EC:1.5.1.7", "l": "\"Saccharopine dehydrogenase (NAD(+), L-lysine-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16964", "l": "epsilon-(gamma-L-glutamyl)-L-lysine <=> 5-oxo-L-proline + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2470555", "l": "Collagen type X binds Integrin alpha2beta1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216045", "l": "Collagen type I binds integrin alpha11beta1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23051", "l": "(S)-3-hydroxybutanoate + 2-oxoglutarate <=> (R)-2-hydroxyglutarate + acetoacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023462", "l": "Tyrosine kinase inhibitors bind and inhibit overexpressed FGFR1 dimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10634", "l": "D-mannuronate + H(+) + NADH => D-mannonate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27467", "l": "ADP-D-glycero-beta-D-manno-heptose + diphosphate => ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032407", "l": "MutSalpha complex binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050118", "l": "N-acetyldiaminopimelate deacetylase activity"}, {"i": "RHEA:20405", "l": "H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + acetate"}, {"i": "EC:3.5.1.47", "l": "\"N-acetyldiaminopimelate deacetylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351894", "l": "Caspase mediated cleavage of BAP31 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37919", "l": "(9Z,12Z)-octadecadienoate + O2 = (8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047060", "l": "(R)-pantolactone dehydrogenase (flavin) activity"}, {"i": "RHEA:21004", "l": "(R)-pantolactone + A = 2-dehydropantolactone + AH2"}, {"i": "EC:1.1.99.27", "l": "\"(R)-pantolactone dehydrogenase (flavin)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052750", "l": "reactive-black-5:hydrogen-peroxide oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800797", "l": "The PIDDosome activates CASP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399995", "l": "Muscarinic Acetylcholine Receptor M3 activates Gq (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19270", "l": "2-furoate + ATP + CoA => 2-furoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016151", "l": "nickel cation binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59206", "l": "AMP + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + H(+) => docosanoyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-167408", "l": "The high affinity receptor complex binds to G-protein (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950567", "l": "Expression of Plasminogen activator inhibitor 2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55194", "l": "2-hydroxy-3-methyldodecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methyldodecanoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36171", "l": "a 1-acylglycerone 3-phosphate + a long chain fatty alcohol = 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)"}, {"i": "EC:2.5.1.26", "l": "\"Alkylglycerone-phosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210292", "l": "Interaction of DAP12 and TREM1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46724", "l": "(2S)-2-methyltetradecanoyl-CoA = (2R)-2-methyltetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58779", "l": "NADP(+) + pyridine 3-methanol <=> H(+) + NADPH + pyridine-3-carbaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.29"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10369", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose => dTDP-4-dehydro-6-deoxy-D-galactose + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43529", "l": "L-serine + NAD(+) => 2-aminomalonate semialdehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2399913", "l": "atRAL binds to RBP2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755600", "l": "Defective DOLK does not phosphorylate DCHOL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64598", "l": "an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H(+) => a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32290", "l": "(2R,3S)-3-isopropylmalate <=> (2S)-2-isopropylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45163", "l": "3-oxopropanoate + H(+) <=> acetaldehyde + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196773", "l": "COASY phosphorylates DP-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18578", "l": "3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine => 3-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296045", "l": "Activation of Potassium transport channels (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58411", "l": "NADP(+) + undecan-1-ol <=> H(+) + NADPH + undecanal"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010437", "l": "9,10 (9', 10')-carotenoid-cleaving dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867041", "l": "EGFR phosphorylates EPS15 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20906", "l": "(S)-1,2-epoxypropane + coenzyme M => (2S)-2-hydroxypropyl-coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23791", "l": "acetate + ATP + holo-[citrate lyase ACP] <=> acetyl-[citrate lyase ACP] + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52714", "l": "2-deoxy-D-ribose 5-phosphate + thymine => dTMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674093", "l": "PDGFRs bind type I TKI (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47670", "l": "2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804596", "l": "APAF1:CYCS binds APIP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209158", "l": "Polymeric PGN bound PGRP-LCx multimerises at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36573", "l": "CoA + H(+) + N-(tetradecanoyl)-sphinganine => sphinganine + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17663", "l": "ADP + phosphate + succinyl-CoA => ATP + CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59233", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => diphosphate + hydropyrenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56966", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate => a 2'-deoxyribonucleoside 5'-triphosphate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451310", "l": "Activation of Edited Kainate receptors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174731", "l": "Degradation of newly synthesized ApoB-48 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114361", "l": "SMAC binds XIAP within apoptosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710917", "l": "ALK fusion proteins bind PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099038", "l": "ceramide floppase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55695", "l": "an inositol-1-phosphoceramide + H2O <=> 1D-myo-inositol 1-phosphate + an N-acyl-sphingoid base + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3095901", "l": "ABCC1 transports cytosolic Cbl to extracellular region (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43584", "l": "H2O + iminoarginine = 5-guanidino-2-oxopentanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990609", "l": "glutamate-cysteine ligase regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0052880", "l": "oxidoreductase activity, acting on diphenols and related substances as donors, with copper protein as acceptor"}, {"i": "EC:1.10.9.-", "l": "\"With a copper protein as acceptor\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004933", "l": "mating-type a-factor pheromone receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28943", "l": "glycine betaine(in) = glycine betaine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16838", "l": "5'-acylphosphoadenosine + H2O => a carboxylate + AMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12025", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + choline => D-glucose + O-sinapoylcholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60946", "l": "H(+) + isorhamnetin + S-adenosyl-L-homocysteine => quercetin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9615249", "l": "ARBs bind AGRT1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39319", "l": "(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH = (8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5675431", "l": "PP2A dephosphorylates RAF1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785762", "l": "IL13RA1 binds TYK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50042", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+) => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11497", "l": "O-acetyl-L-serine + uracil => 3-(uracil-1-yl)-L-alanine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30484", "l": "N-hydroxy-L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21582", "l": "(R)-acetoin + CO2 => (2S)-2-acetolactate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051990", "l": "(R)-2-hydroxyglutarate dehydrogenase activity"}, {"i": "RHEA:38295", "l": "(R)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2"}, {"i": "EC:1.1.99.39", "l": "\"D-2-hydroxyglutarate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71445", "l": "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203553", "l": "eNOS binds NOSIP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046972", "l": "histone acetyltransferase activity (H4-K16 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004845", "l": "uracil phosphoribosyltransferase activity"}, {"i": "RHEA:13017", "l": "diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil"}, {"i": "EC:2.4.2.9", "l": "\"Uracil phosphoribosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0031705", "l": "bombesin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693575", "l": "DNA-PKcs autophosphorylates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21592", "l": "(2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD(+) = H(+) + L-2-aminopentanoate + NADH + pyruvate"}, {"i": "EC:1.5.1.28", "l": "\"Opine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0047134", "l": "protein-disulfide reductase (NAD(P)) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38872", "l": "uridine(2457) in 23S rRNA => pseudouridine(2457) in 23S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.13", "l": "\"Manganese peroxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31862", "l": "(S)-2,3-epoxysqualene <=> glutinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602454", "l": "proMMP9 binds TIMP1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5633051", "l": "EFCAB7:IQCE binds EVC2:EVC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451942", "l": "Within the IL-2R complex JAK3 phosphorylates JAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2730872", "l": "Activation of Calcineurin (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63717", "l": "losartan + UDP-alpha-D-glucuronate => losartan-1-N-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54075", "l": "(2E)-geranyl diphosphate <=> beta-thujene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-349626", "l": "Integrin alpha2beta1 binds laminin-332 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15483", "l": "(6S)-5,6,7,8-tetrahydrofolate + L-serine => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62712", "l": "betaenone C + H(+) + NADPH + O2 = H2O + NADP(+) + stemphyloxin I"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21062", "l": "CoA + N-(3,4-dichlorophenyl)malonamate => 3,4-dichloroaniline + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534365", "l": "Slo3 Potassium Transport (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853444", "l": "AURKA phosphorylates PHLDA1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33586", "l": "L-glutamate + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate <=> 2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58653", "l": "rifamycin SV ortho-naphthoquinone carboxamide => rifamycin SV para-naphthoquinone carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19094", "l": "2 H(+) + siroheme => 12,18-didecarboxysiroheme + 2 CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0019117", "l": "dihydroxyfluorene dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004156", "l": "dihydropteroate synthase activity"}, {"i": "RHEA:19949", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate"}, {"i": "EC:2.5.1.15", "l": "\"Dihydropteroate synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004651", "l": "polynucleotide 5'-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730892", "l": "Recruitment of VAV to p-SLP-76 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51151", "l": "a primary alcohol + 2 oxidized [azurin] <=> an aldehyde + 2 H(+) + 2 reduced [azurin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018473", "l": "cis-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299338", "l": "Activation of TRESK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40968", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73577", "l": "CAD hexamer transforms L-Gln to CAP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61580", "l": "(3S)-3-hydroxycyclohexane-1-carbonyl-CoA + NADP(+) = (5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655262", "l": "Activated FGFR3 mutants bind FRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11897", "l": "7alpha-hydroxycholesterol + NAD(+) => 7alpha-hydroxycholest-4-en-3-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993769", "l": "Transfer of SUMO3 from E1 to UBE2I (UBC9) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-880053", "l": "2-oxoglutarate + NADPH + H+ => (R)-2-hydroxyglutarate + NADP+ [mutant IDH1] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848087", "l": "STAP2 recruits STAT3 to PTK6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22080", "l": "H(+) + NADH + O2 + quinolin-2-ol = H2O + NAD(+) + quinoline-2,8-diol"}, {"i": "EC:1.14.13.61", "l": "\"2-hydroxyquinoline 8-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004321", "l": "fatty-acyl-CoA synthase activity"}, {"i": "RHEA:22896", "l": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+)"}, {"i": "EC:2.3.1.86", "l": "\"Fatty-acyl-CoA synthase system\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647660", "l": "GSDME (1-270) binds PIPs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49291", "l": "(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] <=> (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55309", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35507", "l": "30-hydroxy-11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = glycyrrhetaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19857", "l": "a 16alpha-hydroxysteroid + NADP(+) = a 16-oxosteroid + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13283", "l": "2-methyl-3-oxobutanoyl-CoA + H(+) + NADH => (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28582", "l": "ATP + dUDP = ADP + dUTP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034933", "l": "1-hydroxy-6-methoxypyrene methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28519", "l": "D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O => D-glycero-beta-D-manno-heptose 1-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043721", "l": "4-hydroxybutanoyl-CoA dehydratase activity"}, {"i": "MetaCyc:RXN-8890"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48953", "l": "14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) => 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19577", "l": "luteolin + UDP-alpha-D-glucose = H(+) + luteolin 7-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24950", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + malonate => 3-hydroxy-3-methylglutarate + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015432", "l": "ABC-type bile acid transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18258", "l": "coproporphyrinogen III + 2 H(+) + O2 => 2 CO2 + 2 H2O + protoporphyrinogen IX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008507", "l": "sodium:iodide symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28394", "l": "L-alanyl-L-glutamate = L-alanyl-D-glutamate"}, {"i": "EC:5.1.1.20", "l": "\"L-Ala-D/L-Glu epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27973", "l": "alpha-maltotriose + H2O <=> alpha-D-glucose + beta-maltose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602272", "l": "Defective CYP4F22 does not 20-hydroxylate TrXA3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113643", "l": "Replication initiation regulation by Rb1/E2F1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46176", "l": "2-methylpropanoate + ATP + CoA = 2-methylpropanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26091", "l": "H2O + limonene 1,2-epoxide + NAD(+) => (4S)-limonene + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57024", "l": "apulose 4-phosphate + D-glyceraldehyde 3-phosphate = D-xylulose 5-phosphate + dihydroxyacetone phosphate"}, {"i": "EC:2.2.1.13", "l": "\"Apulose-4-phosphate transketolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395992", "l": "p-T,4S-IRF3 is dimerized (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62635", "l": "a hydroperoxide + 2 glutathione <=> an alcohol + glutathione disulfide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23881", "l": "L-histidyl-[protein] + phosphoenolpyruvate => N(pros)-phospho-L-histidyl-[protein] + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388560", "l": "EDNRA,EDNRB bind EDNs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18766", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine => a 1,2-diacyl-sn-glycerol + a sphingomyelin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018747", "l": "RHOQ GEFs activate RHOQ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928645", "l": "EPHB:NMDAR binds TIAM1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419426", "l": "Cannabinoid receptors can bind cannabinoids (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.34"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433374", "l": "Processing of SCF isoform 1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222237", "l": "SMYD2 methylates TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714483", "l": "RAC2 translocates to the ER membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11483", "l": "3-hydroxybenzoate + H(+) + NADPH + O2 <=> 3,4-dihydroxybenzoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60782", "l": "CO2 + gibberellin A24 + H2O + succinate => 2-oxoglutarate + gibberellin A15 + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003980", "l": "UDP-glucose:glycoprotein glucosyltransferase activity"}, {"i": "REACT:R-HSA-548884", "l": "UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004709", "l": "MAP kinase kinase kinase activity"}, {"i": "REACT:R-HSA-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60223", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(4)-[histone H3] + O2 <=> CO2 + formaldehyde + L-lysyl(4)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265010", "l": "Cystine-bonded Proinsulin translocates from the endoplasmic reticulum to the Golgi (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395439", "l": "Phosphorylation of DAP12 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8948136", "l": "ULK1 Translocates to the mitochondria (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31204", "l": "acetyl-CoA + hexanoyl-CoA => 3-oxooctanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162657", "l": "Inactivation of Myt1 kinase (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46240", "l": "2 [Fe(II)-cytochrome b5] + a (9Z)-hexadecenoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (9Z,12E)-hexadecadienoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42662", "l": "H(+) + NADH + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose => NAD(+) + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373705", "l": "Caspase cleavage of DCC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625863", "l": "RETN gene expression is stimulated by FOXO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018568", "l": "3,4-dihydroxyphenanthrene dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55523", "l": "dimethylallyl diphosphate + 3 isopentenyl diphosphate <=> 3 diphosphate + nerylneryl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22633", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + isopentenyl diphosphate => all-trans-hexaprenyl diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050028", "l": "L-lysine-lactamase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450550", "l": "PKCalpha phosphorylates HuR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44153", "l": "1D-myo-inositol 2-phosphate + H2O => myo-inositol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000319", "l": "BORA binds PLK1 and AURKA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9696274", "l": "RND1 binds GTP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57923", "l": "4-phosphooxy-L-aspartyl-tRNA(Asn) + NH4(+) <=> H(+) + L-asparaginyl-tRNA(Asn) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66051", "l": "2-oxobutanoate + L-kynurenine <=> (2S)-2-aminobutanoate + 4-(2-aminophenyl)-2,4-dioxobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2214351", "l": "PLK1 phosphorylates GORASP1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.8.-", "l": "\"With a flavin as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.n5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340124", "l": "CSN polymer binds CaPO4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9007882", "l": "IL1F10 is cleaved (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3134953", "l": "DHX36 or DHX9 binds MyD88 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52863", "l": "a short-chain fatty acid + ATP + CoA <=> a short chain fatty acyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50228", "l": "FADH2 + O2 + resorcinol = benzene-1,2,4-triol + FAD + H(+) + H2O"}, {"i": "EC:1.14.14.27", "l": "\"Resorcinol 4-hydroxylase (FADH(2))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917987", "l": "TFRC dimer binds 2xholoTF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706344", "l": "FLT3 phosphorylates GRB10 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32852", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617879", "l": "HOXA4 mRNA is translated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26479", "l": "1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) => a 2-demethylmenaquinol + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008728", "l": "GTP diphosphokinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2203479", "l": "STAB2 (FEEL-2) binds ligands (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10442", "l": "D-gluconate + H(+) => D-glucono-1,5-lactone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77068", "l": "Activation of GT (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390663", "l": "ADRA2A,B,C bind ADR,NAd (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22175", "l": "beta-D-fructose 6-phosphate + UDP-alpha-D-glucose <=> H(+) + sucrose 6(F)-phosphate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804527", "l": "INTL1 binds bacterial glycans (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15825", "l": "AZD1979 + H2O = AZD1979 oxetane hydrolysis product + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450533", "l": "PKCdelta phosphorylates HuR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018750", "l": "biuret amidohydrolase activity"}, {"i": "RHEA:17525", "l": "biuret + H2O = NH4(+) + urea-1-carboxylate"}, {"i": "EC:3.5.1.84", "l": "\"Biuret amidohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209944", "l": "25(OH)D binds GC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29826", "l": "chloride(in) <=> chloride(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848339", "l": "PNPLA5 hydrolyzes TAG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692154", "l": "SOX9 binds the PTGDS gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5250930", "l": "B-WICH recruits histone acetyltransferases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8963915", "l": "1,25(OH)2D binds VDR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9639286", "l": "RRAGC,D exchanges GTP for GDP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46492", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(in) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033964", "l": "glycosphingolipid deacylase activity"}, {"i": "MetaCyc:3.5.1.69-RXN"}, {"i": "EC:3.5.1.69", "l": "\"Glycosphingolipid deacylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008878", "l": "glucose-1-phosphate adenylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047184", "l": "1-acylglycerophosphocholine O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31329", "l": "bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate + CMP + H(+) => 1D-myo-inositol 3-phosphate + CDP-1L-myo-inositol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16663", "l": "5'-deoxy-5'-fluoroadenosine + L-methionine => fluoride + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23349", "l": "(R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+) => (4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.n2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46971", "l": "A + dihydroisopentenyldehydrorhodopin <=> AH2 + isopentenyldehydrorhodopin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296045", "l": "Activation of Potassium transport channels (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201603", "l": "Caspase-mediated cleavage of PKC theta (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34898", "l": "ATP + H2O + selenite(out) <=> ADP + H(+) + phosphate + selenite(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33196", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17815", "l": "H(+) + keto-D-tagaturonate + NADH => D-altronate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174438", "l": "Formation of the Flap Intermediate on the C-strand (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0015930", "l": "glutamate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19956", "l": "a 2-oxocarboxylate + L-alanine <=> an L-alpha-amino acid + pyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032778", "l": "P-type cobalt transporter activity"}, {"i": "RHEA:32779", "l": "ATP + Co(2+)(out) + H2O = ADP + Co(2+)(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83660", "l": "Membrane-anchored TNF-alpha binds TNFR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18864", "l": "a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine <=> a 5-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34346", "l": "(20R,22R)-20,22-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 4-methylpentanal + 2 H2O + 2 oxidized [adrenodoxin] + pregnenolone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350901", "l": "Iodide is organified (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22231", "l": "H(+) + NADH + presqualene diphosphate <=> diphosphate + NAD(+) + squalene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40692", "l": "1-hexadecanoylglycerone 3-phosphate + pentadecan-1-ol => 1-O-pentadecylglycerone 3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106291", "l": "superoxide-generating NADH oxidase activity."}, {"i": "RHEA:63184", "l": "NADH + 2 O2 = H(+) + NAD(+) + 2 superoxide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033902", "l": "rRNA endonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432295", "l": "GPVI binds Fyn and Lyn (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65240", "l": "(11Z)-octadecenoyl-CoA + H2O = (11Z)-octadecenoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37180", "l": "(9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate => (6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63981", "l": "4-thiouridine + ATP => 4-thiouridine 5'-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22287", "l": "2 H(+) + H2O + N-carbamoylputrescine <=> CO2 + NH4(+) + putrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247569", "l": "PADI4 deiminates Histones (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39201", "l": "(2E)-tetracosenoyl-CoA + H2O => (3R)-hydroxytetracosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36937", "l": "(9Z,11E)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (11E)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673173", "l": "NBEA binds GLRB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009940", "l": "amino-terminal vacuolar sorting propeptide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814678", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654515", "l": "KAL1 binds HS (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46786", "l": "a 1-[(9Z,12Z,15Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9619756", "l": "NR1H2 binds ABCA1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40057", "l": "2,3-dioctanoyl-sn-glycerol + H(+) + octanoate => 1,2,3-trioctanoylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22066", "l": "ergosterol + H2O => 5alpha-ergosta-7,22-diene-3beta,5-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-378975", "l": "Follitropin is a heterodimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062213", "l": "peroxynitrite isomerase activity"}, {"i": "RHEA:63116", "l": "peroxynitrite = nitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9734687", "l": "ORC6 is phosphorylated on T195 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13539", "l": "2-O-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+) => (2R)-3-phosphoglycerate + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0016723", "l": "oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082369", "l": "Acetylated HSF1 dissociates from DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23170", "l": "8-oxocoformycin + H(+) + NADPH => coformycin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14755", "l": "acetate + androst-4-ene-3,17-dione + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28021", "l": "enterobactin + 3 H2O <=> 2 H(+) + 3 N-(2,3-dihydroxybenzoyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198314", "l": "DAG stimulates protein kinase C-delta (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22320", "l": "2 alpha-D-glucose 1-phosphate + H2O = D-maltose + 2 phosphate"}, {"i": "EC:2.4.1.139", "l": "\"Maltose synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229343", "l": "AXIN is phosphorylated in the destruction complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37941", "l": "(8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate => (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444171", "l": "Receptor FFAR2 binds carboxylates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416683", "l": "SEMA3E binds to PLXND1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3134962", "l": "DHX36 binds DNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42448", "l": "(R)-2-hydroxyglutaryl-CoA = (2E)-glutaconyl-CoA + H2O"}, {"i": "EC:4.2.1.167", "l": "\"(R)-2-hydroxyglutaryl-CoA dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57238", "l": "N(2)-(1-hydroxy-2-oxopropyl)-GMP => GMP + methylglyoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66174", "l": "H(+)(in) + L-cystine(in) => H(+)(out) + L-cystine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50199", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47771", "l": "guanosine(2270) in 21S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(2270) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40669", "l": "2-iminopropanoate => 2-aminoprop-2-enoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67120", "l": "N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8941895", "l": "Formation of CDK4/6:CCND complexes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12254", "l": "(E)-coniferol + D-glucose => 4-O-(beta-D-glucosyl)-trans-coniferol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58044", "l": "a long-chain fatty acyl-CoA + alpha,alpha-trehalose = 2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + CoA"}, {"i": "EC:2.3.1.279", "l": "\"Long-chain-acyl-CoA--trehalose acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51797", "l": "deoxycohumulone + dimethylallyl diphosphate => colupulone + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50019", "l": "H2O + octanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + octanoyl-4'-phosphopantetheine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55732", "l": "19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] = 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26099", "l": "H2O + limonene 1,2-epoxide + NADP(+) => (4R)-limonene + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44920", "l": "(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH = (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34649", "l": "3-methyl-1,2-didehydro-2,3-dihydrosqualene + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + squalene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382061", "l": "Extracellular processing of novel PDGFs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654752", "l": "ATF4 binds the PPP1R15A (GADD34) promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56559", "l": "(2E,6E)-farnesyl diphosphate <=> delta-cadinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64534", "l": "2 [Fe(III)-cytochrome b5] + an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + H2O => 2 [Fe(II)-cytochrome b5] + an N-(1,2 saturated very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803400", "l": "TP53 stimulates PCBP4 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035279", "l": "Expression of APOC4 regulated by NR1H2 or NR1H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983158", "l": "Trimming of peptides in ER (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684140", "l": "ATM phosphorylates RBBP8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52720", "l": "5-methyluridine(54) in tRNA + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + ATP + H2O = 5-methyl-2-thiouridine(54) in tRNA + [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + AMP + diphosphate + 2 H(+)"}, {"i": "EC:2.8.1.15", "l": "\"tRNA-5-methyluridine(54) 2-sulfurtransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83793", "l": "Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708466", "l": "BACH1 translocates from the nucleoplasm to the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52569", "l": "epitestosterone + UDP-alpha-D-glucuronate => epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247837", "l": "WNT ligands traffic to the Golgi (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65855", "l": "a 3-oxo-Delta(1)-steroid + H2O <=> a 1-hydroxy-3-oxo steroid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388808", "l": "CD28 homodimer binds B7-2 monomer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45859", "l": "3-hydroxytetradecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(2-hydroxytridecyl)-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102158", "l": "very-long-chain 3-hydroxyacyl-CoA dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047480", "l": "UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209960", "l": "Diiodinated tyrosine can be deiodinated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5444523", "l": "Formation of MSH1:PMS2 Complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22581", "l": "(S)-4-hydroxy-2-oxopentanoate => (2Z)-2-hydroxypenta-2,4-dienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070405", "l": "ammonium ion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54916", "l": "9-cis-retinol + NADP(+) = 9-cis-retinal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218821", "l": "PDK1 phosphorylates PKC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9619355", "l": "CaMKK autophosphorylates in the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987214", "l": "p-STAT3 dimerizes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168136", "l": "Activated JNKs phosphorylate c-JUN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51554", "l": "H(+) + L-xylo-3-hexulose + NADPH => D-sorbitol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080044", "l": "quercetin 7-O-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53352", "l": "5,6-dihydrouridine(20b) in tRNA + NAD(+) = H(+) + NADH + uridine(20b) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39278", "l": "(2E,15Z)-tetracosadienoyl-CoA + H(+) + NADPH <=> (15Z)-tetracosenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58796", "l": "a flavonol 7-O-beta-D-glucoside + malonyl-CoA = a flavonol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168140", "l": "Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65652", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontanoyl)-sphing-4-enine = a diacylglycerol + N-(32-(9Z,12Z-octadecadienoyloxy)-dotricontanoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28646", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-zingiberene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45162", "l": "acetaldehyde + CO2 => 3-oxopropanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15079", "l": "(R)-pantetheine + CO2 => H(+) + N-[(R)-pantothenoyl]-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928620", "l": "PAK1 autophosphorylates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15706", "l": "2 a ubiquinone + H2O + phenylacetyl-CoA => 2 a ubiquinol + phenylglyoxylyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804266", "l": "CHEK2 phosphorylates TTC5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52956", "l": "hyodeoxycholate + UDP-alpha-D-glucuronate = hyodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70475", "l": "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0031714", "l": "C5a anaphylatoxin chemotactic receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44331", "l": "1-octanoylglycerol + H2O <=> glycerol + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25796", "l": "2-oxoglutarate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + L-glutamate"}, {"i": "EC:2.6.1.57", "l": "\"Aromatic-amino-acid transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24829", "l": "ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16896", "l": "pyridine + S-adenosyl-L-methionine <=> N-methylpyridinium + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607740", "l": "PKC-delta phosphorylates CARD9 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000327", "l": "PLK1 phosphorylates BORA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847537", "l": "RAB43:GTP binds USP8NL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52954", "l": "lithocholoyl-24-O-(beta-D-glucuronate) + UDP => lithocholate + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871373", "l": "BMX phosphorylates RUFY1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21282", "l": "H(+) + 2 H2O2 + thiamine acetate => H2O + 2 O2 + thiamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72631", "l": "Formation of the cap-binding eIF4F complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099508", "l": "voltage-gated ion channel activity involved in regulation of presynaptic membrane potential"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043024", "l": "ribosomal small subunit binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38415", "l": "1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O = (9Z,12Z,15Z)-octadecatrienoate + 2,3-di-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109701", "l": "PDPK1 binds PIP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21941", "l": "AH2 + O2 + squalene => (S)-2,3-epoxysqualene + A + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036106", "l": "peroxisome membrane class-2 targeting sequence binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40328", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28319", "l": "scutellarein + UDP-alpha-D-glucuronate => scutellarin + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080133", "l": "midchain alkane hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47319", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA <=> (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45714", "l": "acetyl-CoA + N,N,N-trimethylglycyl-CoA => 3-dehydrocarnityl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354073", "l": "Autophosphorylation of PTK2 at Y397 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64197", "l": "an N-(fatty acyl)-L-lysine + H2O => a fatty acid + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-452100", "l": "SHC1 bound to IL2 receptor is phosphorylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53400", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.15"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.31"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390929", "l": "HTR1 and 5A receptors can bind serotonin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13596", "l": "allantoate + 2 H(+) + H2O <=> CO2 + NH4(+) + ureidoglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730841", "l": "Phosphorylation and activation of VAV (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26057", "l": "diphosphate + GDP-valienol => GTP + H(+) + valienol 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41158", "l": "1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-8E-octadecenoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45548", "l": "[R-phycocyanin alpha-subunit]-Cys(84)-phycourobilin = (2R,3E)-phycoerythrobilin + apo-[R-phycocyanin alpha-subunit]"}, {"i": "EC:4.4.1.33", "l": "\"R-phycocyanin alpha-cysteine-84 phycourobilin lyase/isomerase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102904", "l": "germacrene C synthase activity"}, {"i": "RHEA:28302", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + germacrene C"}, {"i": "EC:4.2.3.60", "l": "\"Germacrene C synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11450", "l": "H(+) + NADH + pregnan-21-al => NAD(+) + pregnan-21-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42213", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O => a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635861", "l": "NUMB:ITCH binds GLI1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23424", "l": "alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate"}, {"i": "EC:5.4.2.10", "l": "\"Phosphoglucosamine mutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59006", "l": "dodecanoate + H(+) + H2O2 => dodecanal + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.96", "l": "\"D-aminoacyl-tRNA deacylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050076", "l": "maleate isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429698", "l": "PRKD1,2,3 phosphorylates COL4A3BP-2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22634", "l": "all-trans-hexaprenyl diphosphate + diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390663", "l": "ADRA2A,B,C bind ADR,NAd (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46579", "l": "(24R)-ethylcholest-5-en-3beta-ol + H(+) + NADPH + O2 <=> 2 H2O + NADP(+) + stigmasterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51974", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => an L-polyhomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.112"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4655374", "l": "SUMOylation of DNMT3B with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50137", "l": "ethyl (9Z)-octadecenoate + H2O => (9Z)-octadecenoate + ethanol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19863", "l": "a 16-oxosteroid + H(+) + NADH => a 16alpha-hydroxysteroid + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990714", "l": "hydroxyproline O-galactosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58586", "l": "(-)-tabersonine + acetate + H(+) => dihydroprecondylocarpine acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70596", "l": "GOT2 dimer deaminates L-Asp (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187828", "l": "Translocation of p21 to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2172678", "l": "PHF8 demethylates histone H4K20me1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43776", "l": "an N-(acyl)-sphingosylphosphocholine(in) = an N-(acyl)-sphingosylphosphocholine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40422", "l": "H2O + phytanoyl-CoA <=> 3,7,11,15-tetramethylhexadecanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42394", "l": "D-galactono-1,5-lactone + H(+) + NADH => D-galactose + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11090", "l": "2 H(+) + triphosphate => H2O + trimetaphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202127", "l": "eNOS synthesizes NO (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0098531", "l": "ligand-activated transcription factor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48567", "l": "9-ribosyl-trans-zeatin 5'-phosphate + H2O <=> D-ribose 5-phosphate + trans-zeatin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27988", "l": "H(+) + methylglyoxal + NADPH => hydroxyacetone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805740", "l": "SETD8 methylates TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009282", "l": "CDK1 phosphorylates RUNX2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247847", "l": "WLS is endocytosed to the early endosome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20615", "l": "adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine => 3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53112", "l": "3alpha-hydroxy-5alpha-androstane 17-O-(beta-D-glucuronate) + NADP(+) = 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008794", "l": "arsenate reductase (glutaredoxin) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196753", "l": "2xPPCS ligates PPanK with Cys (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37869", "l": "1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58183", "l": "(1R,2R,3R)-prephytoene diphosphate + H(+) + NADPH <=> all-trans-lycopaoctaene + diphosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66788", "l": "N-methyl-L-dopa + O2 = (3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983421", "l": "Journey of cargo through Golgi complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47461", "l": "3-oxo-(5Z-tetradecenoyl)-CoA + CoA => (3Z)-dodecenoyl-CoA + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013110", "l": "RHOC binds effectors at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140701", "l": "3',3'-cyclic GMP-AMP synthase activity"}, {"i": "RHEA:35647", "l": "ATP + GTP = 3',3'-cGAMP + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "77.690207805941611", "identifiers": [{"i": "GO:0008484", "l": "sulfuric ester hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-708349", "l": "Activated NOD2 oligomerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29765", "l": "ADP + H(+) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) + phosphate => ATP + H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69142", "l": "Recruitment of Dna2 endonuclease (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11454", "l": "H(+) + H2O + loganin + oxidized [NADPH--hemoprotein reductase] => 7-deoxyloganin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004489", "l": "methylenetetrahydrofolate reductase (NAD(P)H) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-888577", "l": "Synthesis of GABA by GAD2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671742", "l": "JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797803", "l": "PTPRD binds SLITRK1-6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38799", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41081", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-(9Z-octadecenoyl)-sn-glycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141159", "l": "TNF-mediated dimerization of procaspase-8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29595", "l": "CoA + NADP(+) + sulfoacetaldehyde = H(+) + NADPH + sulfoacetyl-CoA"}, {"i": "EC:1.2.1.81", "l": "\"Sulfoacetaldehyde dehydrogenase (acylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42233", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z)-octadecenoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47976", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047557", "l": "3-aci-nitropropanoate oxidase activity"}, {"i": "KEGG.REACTION:R01609"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021847", "l": "CREB1 gene expression is stimulated by MECP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102982", "l": "UDP-3-dehydro-alpha-D-glucose dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112396", "l": "Separation of elongating transcript from template (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446372", "l": "Association of  PARVA with TESK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948536", "l": "PTENP1 mRNA binds miR-20 RISC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50685", "l": "H2O + N(5)-phenyl-L-glutamine => aniline + H(+) + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191763", "l": "snRNP:Snurportin complex formation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35679", "l": "dodecanoyl-CoA + H(+) + L-serine = 3-oxotetradecasphinganine + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791154", "l": "Expression of GOSR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55647", "l": "ATP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] <=> ADP + C-terminal S-cyanate-L-cysteinyl-[HypE protein] + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44106", "l": "decanoate + 2 H(+) + NADH => decanal + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65870", "l": "1,17beta-dihydroxyandrostan-3-one => Delta(1)-dihydrotestosterone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357483", "l": "RAC1 binds PAK1-3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009039", "l": "urease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20619", "l": "H(+) + H2O2 + L-ascorbate => L-galactono-1,4-lactone + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45302", "l": "an N-acyl-sphingoid base + H(+) + phosphocholine => an N-(acyl)-sphingosylphosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023451", "l": "FGFR1c P252X mutants bind ligand with enhanced affinity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44961", "l": "(2E)-decenoyl-CoA + H(+) + NADPH => decanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54323", "l": "2 [Fe(II)-cytochrome b5] + a Delta(7)-sterol + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a Delta(5),Delta(7)-sterol + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34246", "l": "GTP + H(+) + Mo-molybdopterin <=> diphosphate + Mo-molybdopterin guanine dinucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32755", "l": "(2S)-naringenin + 2-oxoglutarate + O2 = apigenin + CO2 + H(+) + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.45", "l": "\"Complement factor I\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018628", "l": "terephthalate 1,2-dioxygenase activity"}, {"i": "MetaCyc:1.14.12.15-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001154", "l": "TFIIIB-class transcription factor complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205136", "l": "GTP-bound RAC contributes to JNK activation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24642", "l": "D-glucose + ergosterol => ergosteryl 3-beta-D-glucoside + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34506", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-epi-alpha-bisabolol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "72.610931868743009", "identifiers": [{"i": "GO:0016725", "l": "oxidoreductase activity, acting on CH or CH2 groups"}, {"i": "EC:1.17.-.-", "l": "\"Acting on CH or CH(2) groups\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50334", "l": "1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112510", "l": "IL6ST is tyrosine phosphorylated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23864", "l": "4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP"}, {"i": "EC:4.6.1.12", "l": "\"2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17627", "l": "H(+) + L-lysine + NADPH + pyruvate => D-lysopine + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8944457", "l": "MAF1 translocates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2089971", "l": "Secretion of collagens (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806610", "l": "Keratin filament formation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009672", "l": "auxin:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.91"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10073", "l": "N,N-dimethylglycine + S-adenosyl-L-methionine => glycine betaine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43567", "l": "4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + L-alanine <=> [5-(aminomethyl)-3-furyl]methyl phosphate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507869", "l": "Aquaporins passively transport glycerol into cells (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34537", "l": "1-deoxy-3-dehydrosphinganine + CO2 + CoA => H(+) + hexadecanoyl-CoA + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14394", "l": "N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine => 3 H(+) + N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11862", "l": "ADP + H(+) + N(tele)-phospho-L-histidyl-[protein] => ATP + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36257", "l": "(6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60658", "l": "1-hexadecanoyl-sn-glycero-2,3-cyclic phosphate + choline => 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0034601", "l": "oxoglutarate dehydrogenase [NAD(P)+] activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159001", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0047364", "l": "desulfoglucosinolate sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784434", "l": "An unknown carrier transports cytosolic glyoxylate to the peroxisome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801101", "l": "RABGGTA binds RABGGTB (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21805", "l": "ATP + myo-inositol => 1D-myo-inositol 3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28500", "l": "S-(hydroxymethyl)mycothiol => formaldehyde + mycothiol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015308", "l": "amiloride:proton antiporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102599", "l": "cytochrome P450 dependent beta-amyrin 12,13beta-epoxidase activity"}, {"i": "MetaCyc:RXN-15383"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27722", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-4-deoxy-4-formamido-beta-L-arabinose = 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP"}, {"i": "EC:2.4.2.53", "l": "\"Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19659", "l": "CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH => CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39490", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA <=> (2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050364", "l": "tryptophan dimethylallyltransferase activity"}, {"i": "RHEA:14173", "l": "dimethylallyl diphosphate + L-tryptophan = 4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate"}, {"i": "EC:2.5.1.34", "l": "\"4-dimethylallyltryptophan synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684806", "l": "Unknown kinase phosphorylates CLEC1B dimer:PDPN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13293", "l": "3 H(+) + malonyl-CoA + 2 NADPH + octadecanoyl-CoA = CO2 + CoA + eicosanoyl-CoA + H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37054", "l": "3-deacetyl-3-vinylbacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate <=> ATP + chlorophyllide a + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10059", "l": "(3S)-3-aminobutanoyl-CoA <=> (2E)-butenoyl-CoA + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48653", "l": "lipoxin B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-lipoxin B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11476", "l": "glycerol 1-phosphate + H2O = glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62222", "l": "neopatulin => phyllostine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37328", "l": "ATP + H2O + L-methionyl-L-alanine(out) => ADP + H(+) + L-methionyl-L-alanine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63202", "l": "(10bS,4aR)-oxomaritidine + NADP(+) => (10bS,4aR)-noroxomaritidine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1640164", "l": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54807", "l": "2 4-sulfanylbutanoate + NAD(+) <=> 4,4'-disulfanyldibutanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473186", "l": "FSTL3 binds Activin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36324", "l": "(9Z)-octadecenoyl-CoA + 2 H(+) + 2 NADPH => (9Z)-octadecen-1-ol + CoA + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60336", "l": "N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928614", "l": "EFNB:GRB4 binds GIT1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429714", "l": "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140769", "l": "factor VII -> factor VIIa (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48338", "l": "a neolactoside III(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+) => a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013108", "l": "GDIs block activation of RHOC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56517", "l": "Fe-coproporphyrin III + 2 H(+) + 2 H2O2 => 2 CO2 + 4 H2O + heme b"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38478", "l": "L-histidine + S-adenosyl-L-methionine <=> H(+) + N(alpha)-methyl-L-histidine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15671", "l": "ADP + H(+) + phospho-5'-(DNA) => 5'-dephospho-(DNA) + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "80.155824608458104", "identifiers": [{"i": "GO:0005543", "l": "phospholipid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34958", "l": "5-(methylsulfanyl)-D-ribose(in) <=> 5-(methylsulfanyl)-D-ribose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25150", "l": "(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde <=> H(+) + H2O + quinolinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25279", "l": "AMP + H(+) => 3',5'-cyclic AMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47883", "l": "dioctanoylglycerol + H2O <=> H(+) + octanoate + octanoylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22963", "l": "formononetin + O2 + reduced [NADPH--hemoprotein reductase] <=> calycosin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48647", "l": "prostaglandin H2 <=> (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668148", "l": "F8 variant is not sulfonated at Y1699 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905131", "l": "carcinine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043812", "l": "phosphatidylinositol-4-phosphate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64463", "l": "acetyl phosphate + L-lysyl-[protein] <=> H(+) + N(6)-acetyl-L-lysyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12465", "l": "myo-inositol + UDP-alpha-D-galactose => alpha-D-galactosyl-(1->3)-1D-myo-inositol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9639286", "l": "RRAGC,D exchanges GTP for GDP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0034235", "l": "GPI anchor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607736", "l": "MALT1 oligomerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021068", "l": "PalmS-ESRs bind CAVs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14854", "l": "4-chlorobenzoyl-CoA + H2O => 4-hydroxybenzoyl-CoA + chloride + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43148", "l": "adenosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.218", "l": "\"tRNA (adenine(9)-N(1))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371385", "l": "TNF-alpha is cleaved by ADAM17 (TACE) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1640164", "l": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004903", "l": "growth hormone receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29087", "l": "(S)-malate + menaquinone-8 = menaquinol-8 + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428127", "l": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863973", "l": "Fusion of ERC and phagosome (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9696274", "l": "RND1 binds GTP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708408", "l": "DICER1 cleaves tRNA Lys TTT 3 in tRNA:HIV RNA hybrid (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034945", "l": "2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1614614", "l": "Cysteine is degraded to serine and H2S (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50758", "l": "2 H(+) + NADPH + oxidized [flavodoxin] => NADP(+) + reduced [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-918224", "l": "DDX58 is K63 polyubiquitinated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.247", "l": "\"[Methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25417", "l": "AH2 + O2 + octadecanoyl-CoA => (9Z)-octadecenoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173705", "l": "C5b binds C6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15574", "l": "N-acetylserotonin + S-adenosyl-L-methionine => H(+) + melatonin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9035484", "l": "CysS248-MPST:TXN2 dissociates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63200", "l": "(10bS,4aR)-noroxomaritidine + H(+) + NADPH = (10bS,4aR)-oxomaritidine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53699", "l": "2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O <=> (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.13.3", "l": "\"Oligonucleotidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004037", "l": "allantoicase activity"}, {"i": "RHEA:11016", "l": "allantoate + H2O = (S)-ureidoglycolate + urea"}, {"i": "EC:3.5.3.4", "l": "\"Allantoicase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32091", "l": "3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine = dTDP + erythromycin D + H(+)"}, {"i": "EC:2.4.1.278", "l": "\"3-alpha-mycarosylerythronolide B desosaminyl transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989746", "l": "Expression of CYP7A1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452100", "l": "SHC1 bound to IL2 receptor is phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70475", "l": "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018730", "l": "glutaconate CoA-transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52715", "l": "dTMP + H2O <=> 2-deoxy-D-ribose 5-phosphate + thymine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031884", "l": "type 1 member 1 taste receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32424", "l": "(1R,4R)-dihydrocarvone + A => (R)-carvone + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202443", "l": "Oligomerization of CARMA1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63587", "l": "2-deoxyecdysone 22-phosphate + H2O <=> 2-deoxyecdysone + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53861", "l": "7beta-hydroxy-3,12-dioxo-5beta-cholan-24-oate + NADP(+) => dehydrocholate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042019", "l": "interleukin-23 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702623", "l": "sorafenib-resistant FLT3 mutants don't bind sorafenib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23505", "l": "adenosylcob(III)inamide + H2O => (R)-1-aminopropan-2-ol + adenosylcob(III)yrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050005", "l": "isohexenylglutaconyl-CoA hydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74712", "l": "Dissociation of IRS-P from insulin receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692315", "l": "OX40L binds OX40 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21961", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + [protein]-disulfide + H(+) + H2O => 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + [protein]-dithiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637806", "l": "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390930", "l": "5-HT2 receptor can bind serotonin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65350", "l": "3-oxochol-4,6-dien-24-oyl-CoA + H2O => 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40533", "l": "H2O + neopikromycin + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47725", "l": "glutathione => 5-oxo-L-proline + L-cysteinylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-421831", "l": "trans-Golgi Network Coat Assembly (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173542", "l": "SMURF2 ubiquitinates SMAD2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14196", "l": "3-hydroxybenzoate + AH2 + O2 <=> 2,3-dihydroxybenzoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30769", "l": "D-glucuronate + H(+) => D-glucurono-3,6-lactone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983158", "l": "Trimming of peptides in ER (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1605624", "l": "Beta-galactosidase hydrolyses GM1 to GM2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36888", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + AH2 + O2 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16945", "l": "(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)"}, {"i": "EC:2.1.2.10", "l": "\"Aminomethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10489", "l": "5-formyltetrahydrofolate + ATP => 5,10-methenyltetrahydrofolate + ADP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21779", "l": "(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA <=> (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55882", "l": "[aequorin] => apo-[aequorin]--coelenterazine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58637", "l": "N-(9Z-octadecenoyl)-(2S)-hydroxyglycine => (9Z)-octadecenamide + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4332235", "l": "CBL binds TGFBR2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047801", "l": "L-cysteine:2-oxoglutarate aminotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006873", "l": "IL21 receptor STAT binding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871260", "l": "YAP1 binds TEAD2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58691", "l": "NADH + O2 + rifamycin SV <=> H2O + NAD(+) + rifamycin SV para-naphthoquinone carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35799", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20343", "l": "1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP => sn-glycerol 3-phosphate + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004053", "l": "arginase activity"}, {"i": "REACT:R-HSA-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "75.076548671259488", "identifiers": [{"i": "GO:0033764", "l": "steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873927", "l": "Release of STAT1 dimer from active receptor unit (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49193", "l": "calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49289", "l": "(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] => (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17563", "l": "acetate + choline + H(+) => acetylcholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24593", "l": "CTP + H(+) + phosphoethanolamine => CDP-ethanolamine + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37792", "l": "aclacinomycin A + O2 => aclacinomycin Y + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675206", "l": "PEA15 binds MAPK monomers and dimers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17714", "l": "(R)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + salutaridine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098604", "l": "adenosylselenohomocysteinase activity"}, {"i": "REACT:R-HSA-2408532", "l": "AdeSeHCys is hydrolysed to SeHCys by AHCY (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16029", "l": "3-guanidinopropanoate + H2O = beta-alanine + urea"}, {"i": "EC:3.5.3.17", "l": "\"Guanidinopropionase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851298", "l": "GPR143 binds L-Dopa (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41401", "l": "1-hexanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexanoyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004895", "l": "cell adhesion receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109862", "l": "MAP2K2 phosphorylates MAPK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264865", "l": "Caspase-mediated cleavage of Lamin A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391377", "l": "Luteinizing hormone receptor can bind LH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22433", "l": "a (3S)-3-hydroxyacyl-CoA + NAD(+) => a 3-oxoacyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15140", "l": "galactitol 1-phosphate + NAD(+) <=> H(+) + keto-L-tagatose 6-phosphate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.25"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213246", "l": "Disassociation of CLIP from MHC II (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51464", "l": "deoxycholate + O2 + reduced [NADPH--hemoprotein reductase] = 1beta-hydroxydeoxycholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15421", "l": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate"}, {"i": "EC:6.2.1.3", "l": "\"Long-chain-fatty-acid--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18257", "l": "coproporphyrinogen III + 2 H(+) + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX"}, {"i": "EC:1.3.3.3", "l": "\"Coproporphyrinogen oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68954", "l": "Mcm2-7 is phosphorylated by DDK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071209", "l": "U7 snRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15743", "l": "2,5-dichlorohydroquinone + H(+) + NADH => 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467659", "l": "AGRN binds NCAM1, PTPRS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43743", "l": "ATP + CoA + hexanoate <=> AMP + diphosphate + hexanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34806", "l": "2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA <=> bisdemethoxycurcumin + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50843", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2029473", "l": "Branching and elongation of mother and daughter filaments (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49875", "l": "(+)-dehydrodiconiferyl acid ketone + a quinone + H2O <=> (+)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001070", "l": "starch binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52441", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose => a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33800", "l": "L-histidinol + NAD(+) => H(+) + L-histidinal + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106063", "l": "G protein-coupled folate receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36006", "l": "(S)-4-hydroxy-2-oxohexanoate <=> propanal + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174438", "l": "Formation of the Flap Intermediate on the C-strand (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429497", "l": "SLP-76 stimulates PLC gamma 2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15356", "l": "all-trans-violaxanthin + L-ascorbate <=> all-trans-antheraxanthin + H2O + L-dehydroascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36564", "l": "GDP-beta-L-colitose + NADP(+) => GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22296", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate = (1R,2R,3R)-prephytoene diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58322", "l": "25-substituted-cholesteryl beta-D-glucoside + an N-acylsphing-4-enine => 25-substituted-cholesterol + a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22578", "l": "an N-acyl-L-homoserine + H(+) => an N-acyl-L-homoserine lactone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40281", "l": "CoA + O-dodecanoyl-R-carnitine => (R)-carnitine + dodecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52227", "l": "3 AH2 + 3 H(+) + heme b + 3 O2 <=> 3 A + biliverdin delta + CO + Fe(2+) + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16865", "l": "choloyl-CoA + propanoyl-CoA = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11943", "l": "2 H(+) + H2O + L-citrulline <=> CO2 + L-ornithine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624112", "l": "CEBPA binds CDK4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39010", "l": "a cholesterol ester(in) <=> a cholesterol ester(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008684", "l": "TBK1 phosphorylation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60725", "l": "dodecanal + H2O + NADP(+) => dodecanoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192061", "l": "CYP46A1 24-hydroxylates CHOL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32075", "l": "geranylgeranyl diphosphate + H2O = (13E)-labda-7,13-dien-15-ol + diphosphate"}, {"i": "EC:3.1.7.10", "l": "\"(13E)-labda-7,13-dien-15-ol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52988", "l": "[deoxyhypusine synthase]-L-lysine + dehydrospermidine = [deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432521", "l": "Nuclear TIM is degraded by the 26S proteasome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10142", "l": "H(+) + NADPH + prostaglandin D2 => NADP(+) + prostaglandin F2alpha"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0046508", "l": "hydrolase activity, acting on carbon-sulfur bonds"}, {"i": "EC:3.13.-.-", "l": "\"Acting on carbon-sulfur bonds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19038", "l": "an epoxide + H2O => an ethanediol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2512800", "l": "SCARB1:ligand is endocytosed (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53415", "l": "(1R,4S)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 <=> (4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40736", "l": "(20S)-ginsenoside Rb1 + 2 H2O => 2 D-glucose + gypenoside LXXV"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9676160", "l": "AAMP binds NOD2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685602", "l": "NCR3LG1 binds NCR3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46121", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202164", "l": "Translocation of PDK1 to Plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36477", "l": "(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19338", "l": "2 hydroxylamine + 2 NAD(+) => 2 H(+) + hyponitrous acid + 2 NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11789", "l": "H2O + L-aspartate + NAD(+) => H(+) + NADH + NH4(+) + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60329", "l": "L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710354", "l": "GSDME (1-270) binds cardiolipin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070968", "l": "pyrroloquinoline quinone binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25794", "l": "ADP + Cu(+)(out) + H(+) + phosphate => ATP + Cu(+)(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0019789", "l": "SUMO transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374896", "l": "Uptake of Noradrenaline (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700149", "l": "Active ALK binds PLCG1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30115", "l": "decanoyl-[ACP] + H2O = decanoate + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45397", "l": "H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017065", "l": "single-strand selective uracil DNA N-glycosylase activity"}, {"i": "REACT:R-HSA-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027281", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46085", "l": "H2O + sn-glycerol 1-phosphate => glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018749", "l": "(3,5-dichlorophenylurea)acetate amidohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19695", "l": "5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH => 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604722", "l": "Activation of proMMP9 by proteases (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55930", "l": "fenbendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => fenbendazole + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35407", "l": "H2O + medicarpin = 4'-methoxyisoflavan-2',4,7-triol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47103", "l": "choloyl-CoA + taurine <=> CoA + H(+) + taurocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.20.2.-", "l": "\"With a cytochrome as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003941", "l": "L-serine ammonia-lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22954", "l": "(2E)-octenedioyl-CoA + H2O2 => O2 + octanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19254", "l": "a sphingomyelin + H2O => an N-acylsphing-4-enine + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975879", "l": "Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21800", "l": "all-trans-antheraxanthin + L-ascorbate = all-trans-zeaxanthin + H2O + L-dehydroascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20750", "l": "CO2 + deacetoxycephalosporin C + H2O + succinate => 2-oxoglutarate + O2 + penicillin N"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31841", "l": "dTDP-3-dehydro-6-deoxy-alpha-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36749", "l": "beta-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18851", "l": "a 2'-hydroxyisoflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 2'-unsubstituted isoflavone + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17014", "l": "H(+) + phosphoenolpyruvate => 3-phosphonopyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693111", "l": "RHOF auto-activates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17598", "l": "2 [Fe(III)cytochrome c] + D-mannitol => 2 [Fe(II)cytochrome c] + D-fructose + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683801", "l": "CHEK2 phosphorylates BRCA1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47253", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2509827", "l": "ITPA hydrolyses ITP to IMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013023", "l": "RHOB GEFs activate RHOB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54297", "l": "GTP + L-tyrosyl-[protein] => diphosphate + O-(5'-guanylyl)-L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2429719", "l": "MCPH1 sequesters condensin II (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65861", "l": "A + Delta(1)-dihydrotestosterone + H2O => 17beta-hydroxyandrostan-1,3-dione + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17875", "l": "ADP + cob(III)alamin(in) + H(+) + phosphate => ATP + cob(III)alamin(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51936", "l": "2-(glutathione-S-yl)-hydroquinone + glutathione = glutathione disulfide + hydroquinone"}, {"i": "EC:1.8.5.7", "l": "\"Glutathionyl-hydroquinone reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879909", "l": "Activation of STAT5a/b by JAK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11022", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 1,4,5-trisphosphate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47037", "l": "uridine in 5S rRNA => pseudouridine in 5S rRNA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047548", "l": "2-methyleneglutarate mutase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8864569", "l": "WWOX binds TFAP2C (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41685", "l": "1-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine + H2O => 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50644", "l": "2-(3-methylsulfanyl)propylmalate = 3-(3-methylsulfanyl)propylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50414", "l": "H(+) + N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu) => L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45246", "l": "(2E,4E)-octadienoyl-CoA => (3E,5Z)-octadienoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63740", "l": "2-phenylacetaldehyde + H(+) + NADH = 2-phenylethanol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030742", "l": "GTP-dependent protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693356", "l": "CEMIP hydrolyses HA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46094", "l": "(25R)-3beta-hydroxy-5-cholesten-26-al + 2 H2O + 2 oxidized [adrenodoxin] => (25R)-cholest-5-ene-3beta,26-diol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23692", "l": "(R)-malate = H2O + maleate"}, {"i": "EC:4.2.1.31", "l": "\"Maleate hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11452", "l": "7-deoxyloganin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + loganin + oxidized [NADPH--hemoprotein reductase]"}, {"i": "RHEA:57576", "l": "7-deoxyloganate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + loganate + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.85", "l": "\"7-deoxyloganate 7-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864718", "l": "TFAP2A,TFAP2C homodimers:CITED2 binds PITX2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204549", "l": "Caveolin-1 binds Basigin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15184", "l": "an acyl-CoA(out) + ATP + H2O <=> ADP + an acyl-CoA(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52437", "l": "a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + an acyl-CoA => 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "67.359228065374083", "identifiers": [{"i": "GO:0016462", "l": "pyrophosphatase activity"}, {"i": "REACT:R-HSA-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653974", "l": "Ragulator binds Rag dimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40381", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-847070", "l": "Phosphorylated TAK1 dissociates from the TLR3 receptor complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57521", "l": "15,16-epoxydolabrene + O2 + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxy-15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52425", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22048", "l": "7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate"}, {"i": "EC:4.2.3.12", "l": "\"6-pyruvoyltetrahydropterin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199203", "l": "PANK1/3/4 phosphorylate PanK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2327733", "l": "FN1 binds Collagen types I-V, VII (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63270", "l": "1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66137", "l": "acetyl-CoA + tyramine => CoA + H(+) + N-acetyltyramine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793949", "l": "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (a branch) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0072545", "l": "tyrosine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848414", "l": "Activated PTK6 binds CDKN1B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085347", "l": "PIAS1 SUMOylates SAFB with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848818", "l": "PTK6 phosphorylates CBL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59662", "l": "D-cellotetraono-1,5-lactone + H2O2 => D-cellotetraose + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134946", "l": "DDX41 ubiquitination by TRIM21 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11825", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O => (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944266", "l": "Association of procollagen type XI (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56393", "l": "[(3R)-hydroxybutanoate](n) + H2O => (3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13950", "l": "H(+) + NADP(+) + 2 reduced [rubredoxin] => NADPH + 2 oxidized [rubredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57072", "l": "3-oxoisoapionate 4-phosphate + H(+) = CO2 + L-erythrulose 1-phosphate"}, {"i": "EC:4.1.1.121", "l": "\"3-oxoisoapionate-4-phosphate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15336", "l": "(S)-ureidoglycolate + NADP(+) <=> H(+) + N-carbamoyl-2-oxoglycine + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15534", "l": "(R)-3-sulfolactate + NAD(+) => 3-sulfopyruvate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26394", "l": "all-trans-zeaxanthin + 2 O2 => 2 (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24407", "l": "(3S)-hydroxy-3-methylglutaryl-CoA <=> acetoacetate + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37262", "l": "(2S)-2-aminobutanoate + H2O + NAD(+) <=> 2-oxobutanoate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38193", "l": "17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41080", "l": "1-(9Z-octadecenoyl)-sn-glycerol + ATP => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31520", "l": "O2 + torulene => 3-methyl-2-butenal + 4'-apo-beta-carotenal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77094", "l": "Formation of cap binding complex (CBC) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49270", "l": "23S,25-dihydroxy-24-oxocholecalciferol + H2O + 2 oxidized [adrenodoxin] => 25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "79.238648346243679", "identifiers": [{"i": "GO:0015166", "l": "polyol transmembrane transporter activity"}, {"i": "REACT:R-HSA-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9649735", "l": "Intrinsic nucleotide exchange on RAS (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24240", "l": "A + AMP + 2 H(+) + sulfite = adenosine 5'-phosphosulfate + AH2"}, {"i": "EC:1.8.99.2", "l": "\"Adenylyl-sulfate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692779", "l": "p-S182 MAPKAPK5 phosphorylates FOXO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65335", "l": "H(+) + NADPH + O2 + verruculide A <=> chrodrimanin E + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212432", "l": "Formation of DRIP coactivator complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114553", "l": "Activation of conventional Protein Kinase C (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0016862", "l": "intramolecular oxidoreductase activity, interconverting keto- and enol-groups"}, {"i": "EC:5.3.2.-", "l": "\"Interconverting keto- and enol-groups\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45482", "l": "(3R,4S,5S,6R)-pentachlorocyclohexene + chloride + H(+) => gamma-hexachlorocyclohexane"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10441", "l": "D-glucono-1,5-lactone + H2O => D-gluconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57200", "l": "glyoxal + L-arginyl-[protein] = N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59556", "l": "H2O + N,N'-diacetylchitobiono-1,5-lactone = H(+) + N,N'-diacetylchitobionate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018466", "l": "limonene-1,2-diol dehydrogenase activity"}, {"i": "EC:1.1.99.-", "l": "\"With other acceptors\""}]}
{"type": "biolink:MolecularActivity", "ic": "66.553158422731826", "identifiers": [{"i": "GO:0140375", "l": "immune receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.80", "l": "\"Membrane-type matrix metalloproteinase-1\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853405", "l": "TPX2 binds AURKA at centrosomes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36211", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60507", "l": "1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004641", "l": "phosphoribosylformylglycinamidine cyclo-ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35974", "l": "12alpha,13alpha-dihydroxyfumitremorgin C + dimethylallyl diphosphate <=> diphosphate + fumitremorgin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33108", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + gamma-muurolene"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:1901235", "l": "(R)-carnitine transmembrane transporter activity"}, {"i": "RHEA:34959", "l": "(R)-carnitine(in) = (R)-carnitine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109858", "l": "MAP2K2 binds MAPK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56281", "l": "3'-L-prolyl-AMP + holo-[peptidyl-carrier protein] => AMP + L-prolyl-[peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38044", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (4Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10135", "l": "ATP + benzoate + CoA <=> AMP + benzoyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187382", "l": "Degradation of ubiquitinated SMAD3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38969", "l": "ADP + an N-acylsphing-4-enine(out) + H(+) + phosphate => an N-acylsphing-4-enine(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55492", "l": "ent-cassa-12,15-dien-2-one + O2 + reduced [NADPH--hemoprotein reductase] = ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23462", "l": "benzyl alcohol + cetraxate + H(+) => benzyl cetraxate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912357", "l": "ITCH ubiquitinates DTX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-167429", "l": "The receptor:G-protein complex  binds GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38340", "l": "(20S)-ginsenoside Rb1 + H2O => (20S)-ginsenoside Rd + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694409", "l": "Nucleotide exchange on RAB1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.11", "l": "\"cAMP-dependent protein kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658438", "l": "SPRED dimer binds NF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57196", "l": "H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] = glycolate + H(+) + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62531", "l": "2 [Fe(II)cytochrome c] + digoxin + 3 H(+) <=> 2 [Fe(III)cytochrome c] + dihydrodigoxin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-918230", "l": "Recruitment of TRAF6/TRAF2 to IPS-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19478", "l": "4-hydroxybenzoate + H(+) + NADPH + O2 => 3,4-dihydroxybenzoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62066", "l": "2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADH => 2-deoxy-D-glucose 6-phosphate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8963734", "l": "IL9 binds IL9R:JAK1 and IL2RG:JAK3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11759", "l": "ATP + biotin + L-lysyl-[protein] <=> AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0043425", "l": "bHLH transcription factor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23904", "l": "an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]"}, {"i": "EC:2.3.2.2", "l": "\"Gamma-glutamyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30063", "l": "2-demethylmenaquinol-8 + S-adenosyl-L-methionine = H(+) + menaquinol-8 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810392", "l": "TMEM55B translocates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140536", "l": "nuclear receptor corepressor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14948", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose <=> a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45330", "l": "7,8-dihydromonapterin => 7,8-dihydroneopterin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010542", "l": "nitrate efflux transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30634", "l": "alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucuronate <=> beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102466", "l": "beta-carotene 2,2'-beta-hydroxylase activity"}, {"i": "MetaCyc:RXN-14019"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30844", "l": "H2O + N-formylmaleamate => formate + H(+) + maleamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35042", "l": "spermidine(in) <=> spermidine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10797", "l": "albendazole + H(+) + NADPH + O2 => albendazole S-oxide + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50118", "l": "CoA + H(+) + N-eicosanoyl-taurine => eicosanoyl-CoA + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177930", "l": "GAB1 phosphorylation by EGFR kinase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13734", "l": "an n-alkanal + NAD(+) => an alk-2-enal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961991", "l": "E2F1 binds the TK1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168950", "l": "TLR6:TLR2 is recruited to ligand:CD14:CD36 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36718", "l": "sphinganine + tetracosenoyl-CoA <=> an N-tetracosenoylsphinganine + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15365", "l": "3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17286", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28605", "l": "L-isoleucine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (1E,2S)-2-methylbutanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6795667", "l": "MDM2 translocates to the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.169"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32753", "l": "choline(in) => choline(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015192", "l": "L-phenylalanine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53537", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O => (13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984775", "l": "Kinesin-9 is a dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24042", "l": "H(+) + NADP(+) + 2 reduced [cytochrome P450] => NADPH + 2 oxidized [cytochrome P450]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11593", "l": "dihydromonacolin L-[lovastatin nonaketide synthase] + H2O => dihydromonacolin L carboxylate + H(+) + holo-[lovastatin nonaketide synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53477", "l": "1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol => (6Z,9Z,12Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043720", "l": "3-keto-5-aminohexanoate cleavage activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60299", "l": "L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389955", "l": "Beta-tubulin:GTP: Cofactor A+ Cofactor D ->  Beta-tubulin:GTP:Cofactor D + Cofactor A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870678", "l": "Cleaved fibrinogen products bind TLR4:LY96 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45953", "l": "L-asparaginyl-[protein] + UDP-alpha-D-glucose => H(+) + N(4)-(beta-D-glucosyl)-L-asparaginyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863727", "l": "STON2 is neddylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003846", "l": "2-acylglycerol O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44123", "l": "hexadecanoyl-CoA + octadecan-1-ol <=> CoA + octadecanyl hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10201", "l": "butanoate + NAD(+) => (2E)-2-butenoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18163", "l": "3-oxohexadecanoyl-CoA + CoA => acetyl-CoA + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9677585", "l": "CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.95", "l": "\"Snake venom factor V activator\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24782", "l": "CO2 + pyropheophorbide a => C-13(2)-carboxypyropheophorbide a + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019160", "l": "NMN nucleosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31545", "l": "2 H(+) + 2 UDP + zeaxanthin bis(beta-D-glucoside) => all-trans-zeaxanthin + 2 UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193669", "l": "TRAF6 binds to p75NTR:NRIF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40121", "l": "CoA + H(+) + tetradecanoate => H2O + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672817", "l": "Active MTORC1 binds the ULK1 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399978", "l": "Protein kinase C, alpha type phosphorylates MARCKS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684887", "l": "Activation of CHEK1 at resected DNA DSBs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25761", "l": "diphosphate + ent-isokaurene => ent-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019702", "l": "protein-arginine N5-methyltransferase activity"}, {"i": "RHEA:48116", "l": "L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.322", "l": "\"Type IV protein arginine methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29972", "l": "2'-deoxyinosine(in) + H(+)(in) => 2'-deoxyinosine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8963851", "l": "VD3 dissociates from GC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052579", "l": "(+)-pulegone reductase, (+)-isomenthone as substrate, activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34457", "l": "9-cis-beta-carotene => all-trans-beta-carotene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31095", "l": "2-methylpropanoyl-CoA + A = (2E)-2-methylpropenoyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429732", "l": "multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41221", "l": "(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30087", "l": "(S)-2-hydroxyglutarate + FAD + H(+) = 2-oxoglutarate + FADH2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008486", "l": "diphosphoinositol-polyphosphate diphosphatase activity"}, {"i": "MetaCyc:3.6.1.52-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170986", "l": "Ral-GDS binds to Ras-GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62581", "l": "ATP + D-cystine(out) + H2O => ADP + D-cystine(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062185", "l": "secalciferol 1-monooxygenase activity"}, {"i": "RHEA:20573", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcitriol + H2O + 2 oxidized [adrenodoxin]"}, {"i": "RHEA:49064", "l": "2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol = calcitetrol + H2O + 2 oxidized [adrenodoxin]"}, {"i": "EC:1.14.15.18", "l": "\"Calcidiol 1-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938930", "l": "RUNX1 binds ELF2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050032", "l": "L-rhamnonate dehydratase activity"}, {"i": "MetaCyc:L-RHAMNONATE-DEHYDRATASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27943", "l": "(3R)-3-hydroxy-D-aspartate => NH4(+) + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20398", "l": "L-cysteine + O-succinyl-L-homoserine => H(+) + L,L-cystathionine + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65924", "l": "2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine = 2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49930", "l": "(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391934", "l": "DP2 receptor can bind PGD2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12630", "l": "2-oxoglutarate + L-hyoscyamine + O2 => (6S)-6-hydroxyhyoscyamine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36179", "l": "1-O-alkyl-2-acyl-sn-glycerol + CDP-choline = 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51280", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate = (9S)-hydroperoxy-(10E,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60294", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35102", "l": "fusidate(in) + H(+)(out) <=> fusidate(out) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61569", "l": "an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O => an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11241", "l": "ATP + thiamine diphosphate => ADP + thiamine triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23099", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP <=> 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38087", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66468", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O = (17E)-cheilanthenediol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9699578", "l": "Active FLT3 phosphorylates CDKN1B (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47695", "l": "AH2 + neomycin C + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + H(+) + L-methionine + neomycin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39222", "l": "3-oxooctacosanyol-CoA + H(+) + NADPH <=> (3R)-hydroxyoctacosanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61728", "l": "a 3-dehydro-D-guloside = a 3-dehydro-D-glucoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66117", "l": "2-oxobutanoate + L-glutamine => (2S)-2-aminobutanoate + 2-oxoglutaramate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70475", "l": "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783530", "l": "gp130:JAKs bind CNTFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199935", "l": "MSK1 activates CREB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388830", "l": "PI3K binds ICOS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0015091", "l": "ferric iron transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797554", "l": "ABP1 binds SHANK proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684250", "l": "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18165", "l": "biphenyl + H(+) + NADH + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)"}, {"i": "EC:1.14.12.18", "l": "\"Biphenyl 2,3-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446364", "l": "Migfilin interacts with VASP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192781", "l": "Viral mRNA Splicing (M, NS segments) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080097", "l": "L-tryptophan:pyruvate aminotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690669", "l": "CD22 binds itself to form homo-oligomers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.98.-", "l": "\"With other, known acceptors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381727", "l": "RAP1A exchanges GDP for GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65381", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidyl-adenosine in mRNA + S-adenosyl-L-methionine => a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidyl-adenosine in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661432", "l": "BIL binds ALB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31468", "l": "beta-D-glucosyl crocetin + UDP-alpha-D-glucose => bis(beta-D-glucosyl) crocetin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29032", "l": "L-glutamate(in) + Na(+)(in) => L-glutamate(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697070", "l": "lprG dissociates from LAM,LM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21140", "l": "ATP + inosine = ADP + H(+) + IMP"}, {"i": "RHEA:27710", "l": "ATP + guanosine = ADP + GMP + H(+)"}, {"i": "EC:2.7.1.73", "l": "\"Inosine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61726", "l": "a 3-dehydro-D-glucoside + H(+) + NADH => a D-glucoside + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17809", "l": "Mg-protoporphyrin IX + S-adenosyl-L-methionine = Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.11", "l": "\"Magnesium protoporphyrin IX methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015444", "l": "P-type magnesium transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624800", "l": "CDK1 phosphorylates LBR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042958", "l": "maltodextrin transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5631941", "l": "SESN1,2,3 bind AMPK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53885", "l": "CDP-alpha-D-glucose + D-glucose 6-phosphate => alpha,alpha-trehalose 6-phosphate + CDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810357", "l": "Fillagrin and keratin intermediate filaments polymerise forming a network (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848314", "l": "IL36:IL1RL2 binds IL1RAP-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66559", "l": "dopamine + L-glutaminyl-[protein] <=> 5-dopaminyl-L-glutamyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36248", "l": "S-adenosyl-L-methionine + trans-anol => H(+) + S-adenosyl-L-homocysteine + trans-anethole"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41576", "l": "dTDP-beta-L-mycarose + erythronolide B = 3-O-alpha-L-mycarosylerythronolide B + dTDP + H(+)"}, {"i": "EC:2.4.1.328", "l": "\"Erythronolide mycarosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5684008", "l": "NBN binds KPNA2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692315", "l": "OX40L binds OX40 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033941", "l": "mannan exo-1,2-1,6-alpha-mannosidase activity"}, {"i": "MetaCyc:3.2.1.137-RXN"}, {"i": "EC:3.2.1.137", "l": "\"Mannan exo-1,2-1,6-alpha-mannosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944232", "l": "Association of procollagen type XII (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011313", "l": "Proteasome degrades ubiquitinated ROBO3.1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428536", "l": "ARHGAP39 (Vilse) binds ROBO1:SLIT2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018737", "l": "2-ketocyclohexane-1-carboxyl-CoA hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444171", "l": "Receptor FFAR2 binds carboxylates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140537", "l": "transcription regulator activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036132", "l": "13-prostaglandin reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392852", "l": "Activated prostacyclin receptor binds G-protein Gs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56464", "l": "1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10150", "l": "deaminohydroxyblasticidin S + NH4(+) => blasticidin S + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391935", "l": "DP1 receptor can bind PGD2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848339", "l": "PNPLA5 hydrolyzes TAG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050185", "l": "phosphatidylinositol deacylase activity"}, {"i": "RHEA:18001", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a carboxylate + H(+)"}, {"i": "EC:3.1.1.52", "l": "\"Phosphatidylinositol deacylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25041", "l": "H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + 2 phosphate"}, {"i": "EC:2.9.1.2", "l": "\"O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49559", "l": "H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] <=> H(+) + L-cysteinyl-[protein] + lactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14245", "l": "ATP + H2O = AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46842", "l": "4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186819", "l": "SH2 domain of Src binds to the active receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42223", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate <=> 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33034", "l": "D-fructose + H(+) + NADH <=> D-sorbitol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-593690", "l": "Phosphorylation of PLCgamma by Netrin-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43547", "l": "ATP + L-glutamate + tyramine <=> ADP + gamma-L-glutamyltyramine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0044620", "l": "ACP phosphopantetheine attachment site binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670620", "l": "Defective DAXX does not bind ATRX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685838", "l": "CX3 complex binds D-loop structures (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28316", "l": "baicalin + UDP => baicalein + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389354", "l": "Activation of Vav1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106275", "l": "NADP+-protein-arginine ADP-ribosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211951", "l": "CYP1B1 4-hydroxylates EST17b (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16920", "l": "2,6-dihydroxypyridine + H(+) + NADH + O2 <=> 2,3,6-trihydroxypyridine + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042767", "l": "ecdysteroid 22-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57853", "l": "a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O => 2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5669158", "l": "NF2 binds PAK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396029", "l": "Latent TGF-beta-3 binds integrins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047416", "l": "arylalkyl acylamidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47527", "l": "cholate + NAD(+) <=> 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40061", "l": "CoA + decanoate + H(+) => decanoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852317", "l": "PLK1 phosphorylates GTSE1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35927", "l": "paromamine + UDP-alpha-D-glucose = 3''-deamino-3''-hydroxykanamycin C + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103091", "l": "2-(7'-methylthio)heptylmalate synthase activity"}, {"i": "MetaCyc:RXNQT-4175"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508451", "l": "PTK2B is phosphorylated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10973", "l": "D-hexose + H(+) + phosphoramidate => alpha-D-hexose 1-phosphate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-879459", "l": "F-actin capping protein is a heterodimer (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28048", "l": "CoA + propanoyl phosphate => phosphate + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29594", "l": "2-hydroxyethane-1-sulfonate + NADP(+) <=> H(+) + NADPH + sulfoacetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003935", "l": "GTP cyclohydrolase II activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47894", "l": "GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "ic": "75.848614326174683", "identifiers": [{"i": "GO:0030594", "l": "neurotransmitter receptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990594", "l": "L-altrarate dehydratase activity"}, {"i": "RHEA:44028", "l": "L-altrarate = 5-dehydro-4-deoxy-D-glucarate + H2O"}, {"i": "EC:4.2.1.156", "l": "\"L-talarate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5627775", "l": "Autophosphorylation of PAK1,2,3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202960", "l": "Caspase mediated cleavage of C-IAP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58977", "l": "H2O + malonaldehyde + O2 => 3-oxopropanoate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38283", "l": "itaconate + succinyl-CoA = itaconyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29009", "l": "H(+)(out) + Mn(2+)(out) => H(+)(in) + Mn(2+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000433", "l": "SUMOylation of PML with SUMO3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17901", "l": "S-adenosyl-L-methionine + xanthotoxol = H(+) + S-adenosyl-L-homocysteine + xanthotoxin"}, {"i": "RHEA:21244", "l": "an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine = an 8-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.70", "l": "\"8-hydroxyfuranocoumarin 8-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42325", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + reduced coenzyme F420-(gamma-Glu)(n) => 3 H(+) + oxidized coenzyme F420-(gamma-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001609", "l": "G protein-coupled adenosine receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683624", "l": "mRNA2 is translated to Spike (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865605", "l": "BRWD1 binds SMARCA4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801195", "l": "STEAP3 binds BNIP3L (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60614", "l": "1-octanoyl-sn-glycero-2,3-cyclic phosphate + choline => 1-octanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0031543", "l": "peptidyl-proline dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13528", "l": "(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] <=> (1R,4R,5R)-5-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13756", "l": "2 L-glutamate + NAD(+) <=> 2-oxoglutarate + H(+) + L-glutamine + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47542", "l": "NADP(+) + ursodeoxycholate => 7-oxolithocholate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42361", "l": "D-allulose => keto-D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21364", "l": "H2O + N-(6-aminohexanoyl)-6-aminohexanoate = 2 6-aminohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654159", "l": "Activated FGFR2 binds PLCG1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937369", "l": "ATAD2 binds ESR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-445714", "l": "Aquaporin-3 passively transports water out of cell (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22181", "l": "(S)-norreticuline + S-adenosyl-L-methionine => (S)-norcodamine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13207", "l": "a UDP-monosaccharide + diphosphate => a monosaccharide 1-phosphate + H(+) + UTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626848", "l": "S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944454", "l": "mTORC1 phosphorylates MAF1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982775", "l": "Growth hormone receptor dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17729", "l": "an acyl-CoA + cholesterol = a cholesterol ester + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36184", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + CDP-choline => a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008113", "l": "peptide-methionine (S)-S-oxide reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31336", "l": "CTP + H(+) + Mo-molybdopterin => diphosphate + Mo-molybdopterin cytosine dinucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67145", "l": "2-oxoglutarate + jasmonate + O2 => (1R,2R)-12-hydroxyjasmonate + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26530", "l": "4-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O"}, {"i": "EC:4.2.1.120", "l": "\"4-hydroxybutanoyl-CoA dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8940554", "l": "MMP2 cleaves OPTC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158137", "l": "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18922", "l": "5alpha-cholest-7-en-3beta-ol + H(+) + NADH + O2 => cholesta-5,7-dien-3beta-ol + 2 H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38525", "l": "(9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+) => 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37357", "l": "phosphate + uridine => H2O + uridine 2'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869694", "l": "oxPL binds CD14 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192051", "l": "CYP7A1 7-hydroxylates CHOL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451839", "l": "DCO binds to FT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265456", "l": "NPC1L1 binds ezetimibe (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10803", "l": "diphosphate + XMP <=> 5-phospho-alpha-D-ribose 1-diphosphate + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390912", "l": "HRH1 binds hist (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909718", "l": "Formation of p-STAT1 homodimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814409", "l": "CK2 phosphorylates PDCL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034894", "l": "4-hydroxypyridine-3-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018839", "l": "cis-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42500", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) = 6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803890", "l": "SFN dimerizes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24923", "l": "L-homoserine = 2-oxobutanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41983", "l": "3alpha-hydroxy-5alpha-pregnan-20-one + NAD(+) <=> 5alpha-pregnane-3,20-dione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042614", "l": "CD70 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49104", "l": "Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine = 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47490", "l": "isodeoxycholate + NADP(+) => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18958", "l": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] => (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009451", "l": "RUNX2 binds SMURF1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46310", "l": "17alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + progesterone + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59978", "l": "CO2 + toluene => 2-phenylacetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1169192", "l": "PTP1B dephosphorylates GHR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682709", "l": "LGI4 binds ADAM22,23,11 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37864", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA => 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22458", "l": "sarcosine + urea => creatine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941312", "l": "ZCCHC6, ZCCHC11 are mRNA uridyltransferases (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-190141", "l": "ALAD binds to Pb2+ (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690785", "l": "BAP1 binds Ub-HCFC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41972", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E)) = CMP + ganglioside GT1aalpha (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10159", "l": "dihydrochelirubine + O2 + reduced [NADPH--hemoprotein reductase] <=> 12-hydroxydihydrochelirubine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29888", "l": "ATP + H2O + L-lysine(out) => ADP + H(+) + L-lysine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209815", "l": "Tyrosine is monoiodinated (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43962", "l": "a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13327", "l": "3 H(+) + 2 NADH + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate => H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25181", "l": "acetyl-CoA + putrescine = CoA + H(+) + N-acetylputrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38080", "l": "2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA => 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172405", "l": "Collagen type XXIII ectodomain shedding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50496", "l": "acetyl-CoA + N-terminal glycyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetylglycyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218806", "l": "FYN autophosphorylates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12497", "l": "2 Fe(2+) + 4 H2O + O2 => 6 H(+) + H2O2 + 2 iron(III) oxide-hydroxide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047791", "l": "cucurbitacin delta23-reductase activity"}, {"i": "MetaCyc:CUCURBITACIN-DELTA-23-REDUCTASE-RXN"}, {"i": "EC:1.3.1.5", "l": "\"Cucurbitacin Delta(23)-reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52134", "l": "5'-phospho-(ribonucleotide)-(DNA) + AMP + 2 H(+) => adenosine-5'-diphospho-5'-(ribonucleotide)-(DNA) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635842", "l": "ULK3 phosphorylates GLI (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24167", "l": "[thioredoxin]-disulfide + H2O + L-methionyl-[protein] <=> [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27532", "l": "(3S,6E)-nerolidol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15431", "l": "5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine => heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25094", "l": "ATP + dCMP = ADP + dCDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59922", "l": "(2E)-octenoate + 2 H(+) + NADH => (2E)-octenal + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1358791", "l": "Phosphorylation of USP8 by P-AKT (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35370", "l": "(2E)-15-methylhexadecenoyl-CoA + H(+) + NADPH <=> isoheptadecanoyl-coA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624132", "l": "UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389381", "l": "Gads binds CD28 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173626", "l": "Activation of C1r (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37976", "l": "H(+) + homogentisate + phytyl diphosphate => 2-methyl-6-phytyl-1,4-benzene-1,4-diol + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854466", "l": "VLDLR binds RELN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928640", "l": "PAKs phosphorylate MLC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9690461", "l": "FKBP1A binds tacrolimus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396371", "l": "NOTCH1 Coactivator Complex binds MYC promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134962", "l": "DHX36 binds DNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60352", "l": "2-heptyl-3-hydroxy-4(1H)-quinolone + O2 = CO + H(+) + N-octanoylanthranilate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57311", "l": "CTP + H(+) + N(5)-phospho-L-glutamine <=> diphosphate + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75850", "l": "Addition of the third nucleotide on the nascent transcript (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8945709", "l": "miR-20 microRNAs bind PTEN mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578777", "l": "DMPK phosphorylates PLN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3266566", "l": "G6PC2 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (islet) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937029", "l": "IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102458", "l": "cyanidin 3-O-glucoside 5-O glucosyltransferase (vanilloyl-glucose dependent) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9611839", "l": "β3-agonists bind ADRB3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.57", "l": "\"Phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30134", "l": "H2O + octanoyl-[ACP] <=> H(+) + holo-[ACP] + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694428", "l": "LMAN family proteins bind glycosylated cargo (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033897", "l": "ribonuclease T2 activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41327", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (12S)-hydroperoxy-(5Z,8Z,10E)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015549", "l": "carbonyl cyanide m-chlorophenylhydrazone transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48065", "l": "ganglioside GD1b (d18:1(4E)) + H2O => ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36385", "l": "AMP + H(+) + nebramycin 5' => carbamoyl adenylate + tobramycin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54816", "l": "L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)"}, {"i": "EC:2.3.2.13", "l": "\"Protein-glutamine gamma-glutamyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51750", "l": "4-amino-4-deoxy-beta-L-arabinopyranosyl-lipid A + di-trans,octa-cis-undecaprenyl phosphate => 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736966", "l": "SMAD7 binds SERPINE1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17744", "l": "NAD(+) + shikimate <=> 3-dehydroshikimate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11998", "l": "biphenyl-2,3-diol + H2O + NAD(+) => biphenyl-2-ol + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13644", "l": "H(+) + methane + NADPH + O2 <=> H2O + methanol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20234", "l": "a 7beta-hydroxysteroid + NADP(+) => a 7-oxosteroid + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381644", "l": "ER calcium channels open in response to activated PKA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981728", "l": "Factor H binds to membrane-associated C3b (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72722", "l": "eIF2 activation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28611", "l": "H2O + XTP => diphosphate + H(+) + XMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199910", "l": "MSK1 activates ATF1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35456", "l": "5alpha-cholest-7-en-3-one + 2 H(+) + 3 NADPH + 3 O2 => (25S)-Delta7-dafachronate + 4 H2O + 3 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49721", "l": "2 H(+) + NADH + 2 O2 + protoviolaceinate => CO2 + 2 H2O + NAD(+) + violacein"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45790", "l": "1,2-dihexadecanoyl-3-(9Z-hexadecenoyl)-sn-glycerol + CoA => (9Z)-hexadecenoyl-CoA + 1,2-dihexadecanoyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198270", "l": "PDPK1 phosphorylates AKT at T308 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48261", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 => CMP + ganglioside GD1a + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607740", "l": "PKC-delta phosphorylates CARD9 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12728", "l": "D-iditol + NAD(+) <=> H(+) + keto-D-sorbose + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65474", "l": "CoA + ethyl 2-methylbutanoate => 2-methylbutanoyl-CoA + ethanol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018576", "l": "catechol 1,2-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46360", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 [Fe(III)-cytochrome b5] + H2O"}, {"i": "EC:1.14.18.4", "l": "\"Phosphatidylcholine 12-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50091", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084507", "l": "Laminin-111 binds endostatin dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3769401", "l": "DKK and KRM bind LRP5/6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21463", "l": "benzoin <=> 2 benzaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.5.2", "l": "\"Proline dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141423", "l": "Binding of the MCC complex to the APC/C complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229348", "l": "Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38956", "l": "an N-acylsphing-4-enine 1-phosphate(in) => an N-acylsphing-4-enine 1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684806", "l": "Unknown kinase phosphorylates CLEC1B dimer:PDPN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64784", "l": "S-ethyl-L-cysteine = 2-aminoprop-2-enoate + ethanethiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664588", "l": "ERBB2 KD mutants trans-autophosphorylate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13830", "l": "GDP-alpha-D-rhamnose + NADP(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804379", "l": "PRMT5 binds TTC5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27402", "l": "2-hydroxychromene-2-carboxylate => (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60997", "l": "H2O + L-leucine + O2 => 4-methyl-2-oxopentanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448958", "l": "Nuclear translocation of p38 MAPK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31245", "l": "(4S)-4-hydroxy-L-glutamate + 2 H(+) + NADH => H2O + L-4-hydroxyglutamate semialdehyde + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57455", "l": "L-glutaminyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.99", "l": "\"Fatty acid amide hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016594", "l": "glycine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654167", "l": "Activated FGFR1 binds PLCG1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160851", "l": "HAS1,2,3 mediate the polymerisation of HA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30691", "l": "H2O2 + methanol = formaldehyde + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428127", "l": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25361", "l": "biliverdin IXalpha + 4 H(+) + 2 reduced 2[4Fe-4S]-[ferredoxin] => (3Z)-phycoerythrobilin + 2 oxidized 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48823", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 <=> 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19884", "l": "GTP + L-lysyl-[protein] <=> diphosphate + H(+) + N(epsilon)-GMP-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50897", "l": "8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O => (8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051060", "l": "pullulanase activity"}, {"i": "EC:3.2.1.41", "l": "\"Pullulanase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37223", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678920", "l": "TLR processing at low pH (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17570", "l": "(R)-reticuline + NADP(+) => 1,2-dehydroreticuline + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353243", "l": "Monoubiquitunated PCNA mediates recruitment of the translesion polymerase to the DNA damaged site. (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50087", "l": "ATP + H2O + taurolithocholate 3-sulfate(in) <=> ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61854", "l": "campesteryl 3-beta-D-glucoside + H(+) + UDP => campesterol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211301", "l": "PDX1-dependent synthesis of IAPP protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31473", "l": "beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP => beta-D-gentiobiosyl crocetin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14105", "l": "L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50932", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50541", "l": "prostaglandin A2 => prostaglandin C2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64286", "l": "2-phenylacetaldehyde + L-alanine => 2-phenylethylamine + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20587", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + secologanin => loganin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665982", "l": "RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163090", "l": "Elongation Of The Telomeric Chromosome End (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1297354", "l": "Acrosin Cleavage (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008453", "l": "alanine-glyoxylate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15128", "l": "acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n) <=> CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.89"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61727", "l": "a D-glucoside + NAD(+) <=> a 3-dehydro-D-glucoside + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983426", "l": "Capturing cargo and formation of prebudding complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58510", "l": "(2S)-2-hydroxy-4-oxobutane-1,2,4-tricarboxylate => (3Z)-2-oxo-4-carboxy-3-hexenedioate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15908", "l": "3-hydroxycyclohexanone + A <=> AH2 + cyclohexane-1,3-dione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30902", "l": "bis(beta-D-glucosyl) crocetin + UDP-alpha-D-glucose <=> beta-D-gentiobiosyl beta-D-glucosyl crocetin + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.104"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788611", "l": "HYKK phosphorylates 5HLYS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033796", "l": "sulfur reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23930", "l": "acetate + spermidine => H2O + N(8)-acetylspermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58450", "l": "H(+) + N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592398", "l": "Activation of proMMP8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49162", "l": "2-exo-hydroxy-1,4-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1,4-cineole + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034805", "l": "benzo(a)pyrene-trans-11,12-dihydrodiol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61258", "l": "2-oxo-3-sulfanylpropanoate + H2O2 + NH4(+) => H2O + L-cysteine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602186", "l": "Defective CYP27B1 does not hydroxylate CDL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38197", "l": "estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45363", "l": "H2O + N-(11Z-eicosenoyl)-sphinganine <=> (11Z)-eicosenoate + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109862", "l": "MAP2K2 phosphorylates MAPK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17166", "l": "alpha-D-galactose 1-phosphate + dTTP + H(+) => diphosphate + dTDP-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50099", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38713", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecylglycerol"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0005345", "l": "purine nucleobase transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37903", "l": "6-hydroxytryprostatin B + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + tryprostatin A"}, {"i": "EC:2.1.1.293", "l": "\"6-hydroxytryprostatin B O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209341", "l": "Phosphorylation of SMO by PKA-C1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420128", "l": "SRC-1 phosphorylates SHB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214878", "l": "PLL kinase binds to TL:WEK:MYD88:TUB 'signalling complex' (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40374", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ATP <=> 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874082", "l": "MET phosphorylates PTK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56907", "l": "an acyl-AMP + CoA <=> AMP + an acyl-CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65978", "l": "previtamin D3 => cholesta-5,7-dien-3beta-ol + hnu"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350651", "l": "Caspase-mediated cleavage of MASK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.33"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48948", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate = 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.3.7.15", "l": "\"Chlorophyllide a reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653936", "l": "Formation of Ragulator complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418904", "l": "A1 and A3 receptors bind adenosine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201515", "l": "Active ALK recruits PI3K (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.42", "l": "\"Branched-chain-amino-acid transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429529", "l": "Thrombin binding to GP1b:IX:V (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626220", "l": "C2CD3 binds the mother centriole (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27932", "l": "(R)-4'-phosphopantothenate + AMP + diphosphate + H(+) => (R)-4-phosphopantoate + ATP + beta-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51308", "l": "H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13210", "l": "A + 3 H2O + trithionate => AH2 + 4 H(+) + 3 sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018483", "l": "6-oxohexanoate dehydrogenase activity"}, {"i": "RHEA:13397", "l": "6-oxohexanoate + H2O + NADP(+) = 2 H(+) + hexanedioate + NADPH"}, {"i": "EC:1.2.1.63", "l": "\"6-oxohexanoate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193997", "l": "CYP11B1 oxidises 11DCORT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34470", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + valerena-4,7(11)-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54129", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56035", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13003", "l": "1L-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate => 1D-myo-inositol hexakisphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44275", "l": "3 H(+) + 3 malonyl-CoA + octadecanoyl-CoA <=> 4-hydroxy-6-(2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10202", "l": "(2E)-2-butenoate + H(+) + NADH => butanoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696482", "l": "CTF1 binds LIFR:JAKs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13753", "l": "2 L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + L-glutamine + NADH"}, {"i": "EC:1.4.1.14", "l": "\"Glutamate synthase (NADH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45878", "l": "6-(hexadecan-2-yl)-4-hydroxy-pyran-2-one + 2 CO2 + 3 CoA => 2-methylhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30593", "l": "(4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+) => H2O + O2 + tyramine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225961", "l": "Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.38", "l": "\"Plasmepsin I\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15375", "l": "H(+) + palmatine + S-adenosyl-L-homocysteine => columbamine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39539", "l": "(2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH = (19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58917", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + squalene => (S)-2,3-epoxysqualene + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14003", "l": "CoA + glycocholate + H(+) => choloyl-CoA + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65086", "l": "aculene D + CO2 + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => asperaculane E + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64253", "l": "glycine + tetradecanoyl-CoA => CoA + H(+) + N-tetradecanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5250930", "l": "B-WICH recruits histone acetyltransferases (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35380", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA => (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50501", "l": "acetyl-CoA + N-terminal L-alanyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29477", "l": "(+)-cubenene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5684006", "l": "KPNA2 translocates NBN to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202717", "l": "Heterodimerization of CEACAMs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62489", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47680", "l": "D-galactosamine 6-phosphate + H2O = D-tagatose 1-phosphate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15855", "l": "17alpha-hydroxyprogesterone + H(+) + NADH => 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592398", "l": "Activation of proMMP8 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57476", "l": "dodecanoate + H2O2 = 2-hydroxydodecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34149", "l": "2-deoxy-scyllo-inosamine + 2-oxoglutaramate => 2-deoxy-L-scyllo-inosose + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655248", "l": "Activated FGFR4 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15937", "l": "a primary alcohol + NADP(+) = an aldehyde + H(+) + NADPH"}, {"i": "EC:1.1.1.2", "l": "\"Alcohol dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635845", "l": "GLI proteins bind CDC73 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44131", "l": "(9E)-octadecenoyl-CoA + hexadecan-1-ol <=> CoA + hexadecanyl (9E)-octadecenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36589", "l": "aldono-1,5-lactone + H(+) + NADPH => an aldopyranose + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399930", "l": "Activation of PAK by Rac1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17264", "l": "a phenyl sulfate + H2O <=> a phenol + H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50201", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033844", "l": "galactose-6-sulfurylase activity"}, {"i": "MetaCyc:2.5.1.5-RXN"}, {"i": "EC:2.5.1.5", "l": "\"Galactose-6-sulfurylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1470010", "l": "Dimerization of STATs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374665", "l": "DCC interaction with SIAH1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62623", "l": "[thioredoxin]-dithiol + a hydroperoxide <=> [thioredoxin]-disulfide + an alcohol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30614", "l": "A + all-trans-zeta-carotene <=> AH2 + all-trans-neurosporene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56663", "l": "7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) <=> 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190829", "l": "Lysosomal degradation of gap junction plaques (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60563", "l": "L-methionyl-[protein] + S-adenosyl-L-methionine <=> S-adenosyl-L-homocysteine + S-methyl-L-methionyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31857", "l": "achilleol B => (S)-2,3-epoxysqualene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617641", "l": "MAFB (KREISLER) and HOXB1:PBX1:PKNOX1 (HOXB1:PBX1:PREP1) activate HOXA3 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52508", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607737", "l": "BCL10 oligomerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442832", "l": "PAK phosphorylates cortactin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8876789", "l": "CARNMT1 methylates CARN to Anserine (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928631", "l": "GIT1 binds bPIX (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042300", "l": "beta-amyrin synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647746", "l": "EML4 trimerizes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21724", "l": "a nitrile + 2 H2O = a carboxylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42094", "l": "all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30587", "l": "2-demethylmenaquinol-8 + dimethyl sulfoxide = 2-demethylmenaquinone-8 + dimethyl sulfide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54999", "l": "3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623643", "l": "RDH13 reduces atRAL to atROL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59345", "l": "D-maltose + O2 => D-maltobiono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031833", "l": "type 7 serotonin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58025", "l": "oleanolate + UDP-alpha-D-glucose => H(+) + oleanolate 3-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22404", "l": "beta-D-galacturonate + NAD(+) = D-galactaro-1,5-lactone + H(+) + NADH"}, {"i": "RHEA:43500", "l": "beta-D-glucuronate + NAD(+) = D-glucaro-1,5-lactone + H(+) + NADH"}, {"i": "EC:1.1.1.203", "l": "\"Uronate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983298", "l": "IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70501", "l": "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420977", "l": "Ca permeable AMPA receptor ligand binding (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14551", "l": "2-oxopent-4-enoate + formate + H(+) => (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16036", "l": "2-oxoglutarate + gibberellin A44 + O2 <=> CO2 + gibberellin A19 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2203480", "l": "COLEC11 binds ligands (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2889070", "l": "SLC9B2 exchanges Na+, Li+ for H+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19235", "l": "H(+) + hexadecanoate + L-cysteinyl-[protein] => H2O + S-hexadecanoyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871376", "l": "p-Y281,292-RUFY1 binds PI3P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.95", "l": "\"Dextran 1,6-alpha-isomaltotriosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987120", "l": "JAK1 binds IFNLR1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48360", "l": "a 1,2-saturated fatty acid + H2O2 = a 2-hydroxy fatty acid + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.1", "l": "\"Steroid Delta-isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26170", "l": "fumarate + H(+) + pyruvate => 3-fumarylpyruvate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29583", "l": "guanosine(in) + H(+)(out) = guanosine(out) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66192", "l": "ATP + bilirubin-bisglucuronoside(in) + H2O = ADP + bilirubin-bisglucuronoside(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42319", "l": "a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022396", "l": "MME:Zn2+ hydrolyses AGT(34-43) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13104", "l": "4-imidazolone-5-propanoate <=> H2O + trans-urocanate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39315", "l": "(3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA = (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1266684", "l": "IL7 binds HGF(495-728) to form PPBSF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48517", "l": "1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O => dodecanoate + dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15793", "l": "bilirubin IXalpha + NADP(+) = biliverdin IXalpha + H(+) + NADPH"}, {"i": "RHEA:15797", "l": "bilirubin IXalpha + NAD(+) = biliverdin IXalpha + H(+) + NADH"}, {"i": "EC:1.3.1.24", "l": "\"Biliverdin reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120048", "l": "U6 snRNA (adenine-(43)-N(6))-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210444", "l": "L-Glutamate loading of synaptic vesicle (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981497", "l": "ST3GAL1-4 can add a sialic acid to the T antigen at the alpha 3 position (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106263", "l": "1-acylglycerophosphoserine O-acyltransferase activity"}, {"i": "RHEA:33191", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA"}, {"i": "EC:2.3.1.n6", "l": "\"1-acylglycerophosphoserine O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730847", "l": "Hydrolysis of PIP2 by PLCG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29846", "l": "ATP + CoA + propanoate <=> ADP + phosphate + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36249", "l": "H(+) + S-adenosyl-L-homocysteine + trans-anethole => S-adenosyl-L-methionine + trans-anol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31219", "l": "5-hydroxykynurenamine + CO2 = 5-hydroxy-L-kynurenine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944215", "l": "Association of procollagen type XX (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682377", "l": "LC3 de-lipidation by ATG4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390141", "l": "D inhibits WTS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34462", "l": "8-hydroxycopalyl diphosphate + H2O <=> diphosphate + sclareol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.4", "l": "\"Dipeptidyl-peptidase III\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.74"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47085", "l": "4-methylsulfanyl-2-oxobutanoate + L-tyrosine => 3-(4-hydroxyphenyl)pyruvate + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-164840", "l": "ADP and Pi bind to ATPase (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-164423", "l": "PhosphoChREBP (Thr 666)  is exported to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66391", "l": "ATP + H2O + prostaglandin E2(in) <=> ADP + H(+) + phosphate + prostaglandin E2(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416690", "l": "SEMA4A binds to PLXND1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53196", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0000182", "l": "rDNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59406", "l": "D-homoserine => L-homoserine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030270", "l": "formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876868", "l": "ECE1 cleaves EDN1(53-90) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56773", "l": "2 AH2 + all-trans-adonixanthin + 2 O2 => 2 A + all-trans-(3S,3'S)-astaxanthin + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985812", "l": "NCK2 binds to ROBO1,(ROBO2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29420", "l": "H(+)(out) + Na(+)(in) => H(+)(in) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140221", "l": "Transactivation of BBC3 (PUMA) by E2F1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.16", "l": "\"Neurolysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35586", "l": "2-dehydro-3-deoxy-D-gluconate <=> D-glyceraldehyde + pyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046789", "l": "host cell surface receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798372", "l": "ATM phosphorylates DYRK2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39602", "l": "3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706330", "l": "Active FLT3 binds to SOCS6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097322", "l": "7SK snRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.8", "l": "\"Ribonuclease M5\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62060", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose = alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66435", "l": "H(+)(out) + L-galactose(out) <=> H(+)(in) + L-galactose(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59254", "l": "(E)-3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA => (E)-3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050059", "l": "lombricine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39048", "l": "26-oxohexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + hexacosanedioate + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48134", "l": "(2E,6E)-farnesol + phosphate => (2E,6E)-farnesyl phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199298", "l": "AKT phosphorylates CREB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11279", "l": "4 hydroquinone + O2 <=> 4 benzosemiquinone + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199161", "l": "Fc gamma receptors interact with antigen-bound IgG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45251", "l": "butanoate(out) <=> butanoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004566", "l": "beta-glucuronidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31226", "l": "cis-beta-D-glucosyl-2-hydroxycinnamate + H2O <=> beta-D-glucose + cis-2-coumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0070456", "l": "galactose-1-phosphate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990593", "l": "nascent polypeptide-associated complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0000702", "l": "oxidized base lesion DNA N-glycosylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9686524", "l": "PP6-PPP6R3 dephosphorylates TERF2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47521", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADPH => isolithocholate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23054", "l": "ADP + H(+) + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] => ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34421", "l": "(+)-pinoresinol + H(+) + NADPH => (+)-lariciresinol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53723", "l": "ATP + N-acetyl-D-muramate <=> ADP + H(+) + N-acetyl-alpha-D-muramate 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212642", "l": "L-Glutamine transport into neurons (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47392", "l": "H2O + hexadecanoate ester = an aliphatic alcohol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071532", "l": "ankyrin repeat binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158849", "l": "Phenol can form a sulfate conjugate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848829", "l": "CBL autoubiquitinates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211951", "l": "CYP1B1 4-hydroxylates EST17b (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201669", "l": "Beta-catenin translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66779", "l": "ATP + H2O + uroporphyrin III(in) <=> ADP + H(+) + phosphate + uroporphyrin III(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15973", "l": "3'-phosphoadenylyl sulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate + H(+)"}, {"i": "EC:2.8.2.4", "l": "\"Estrone sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0106228", "l": "peptide glutaryltransferase activity"}, {"i": "RHEA:18009", "l": "glutaryl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-glutaryl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15321", "l": "(6aR,11aR)-3,9-dihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] = (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.93", "l": "\"3,9-dihydroxypterocarpan 6A-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16811", "l": "pyruvate + succinate => (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400204", "l": "PPARA binds RXRA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53936", "l": "O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 = 19-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62118", "l": "NH4(+) + oxaloacetate => H2O + iminosuccinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66208", "l": "(8R)-8-hydroxynonanoyl-CoA + O2 = (2E,8R)-8-hydroxynonenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174235", "l": "Association of Emi1 with Cdc20 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57743", "l": "a 2,3-saturated meromycolyl-[ACP] + NAD(+) <=> a trans-Delta(2)-meromycolyl-[ACP] + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62724", "l": "(+)-premalbrancheamide + bromide + FAD + 2 H(+) = (+)-isomalbrancheamide C + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53731", "l": "H2O + N-acetyl-D-muramate 6-phosphate <=> N-acetyl-D-muramate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603784", "l": "PEX19:class I PMP binds PEX3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58704", "l": "rifampicin hemiaminal = rifampicin ortho-naphthoquinone carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43102", "l": "2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(44) in tRNA(Ser)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013145", "l": "RAC1 binds effectors at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18859", "l": "6beta-hydroxylithocholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lithocholate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110218", "l": "Cleavage of uracil by TDG glycosylase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15944", "l": "H2O + N(2)-acetyl-L-ornithine <=> acetate + L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201629", "l": "Caspase-mediated cleavage of Tau (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32215", "l": "(6R)-NADHX = (6S)-NADHX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31511", "l": "chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41687", "l": "1-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine + H2O <=> 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61407", "l": "ATP + N-(D-ribulosyl)-cadaverine <=> ADP + H(+) + N-(3-O-phospho-D-ribulosyl)-cadaverine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10228", "l": "citrate = cis-aconitate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975633", "l": "atROL binds to RBP2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37892", "l": "aclacinomycin T + H2O => 15-demethylaclacinomycin T + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37567", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine = 1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62351", "l": "H(+) + NADPH + notoamide E + O2 <=> H2O + NADP(+) + notoamide C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14014", "l": "3'-phosphoadenylyl sulfate + taurolithocholate => adenosine 3',5'-bisphosphate + H(+) + taurolithocholate 3-sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19554", "l": "H2O + L-tryptophan => indole + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1980122", "l": "DTX binds NOTCH1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042878", "l": "D-glucarate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14723", "l": "H(+) + O-beta-D-xylosylzeatin + UDP => UDP-alpha-D-xylose + zeatin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33363", "l": "D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein] = D-mannitol 1-phosphate(in) + L-histidyl-[protein]"}, {"i": "EC:2.7.1.197", "l": "\"Protein-N(pi)-phosphohistidine--D-mannitol phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43103", "l": "S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) <=> 2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013009", "l": "RHOA binds effectors at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35633", "l": "cyanidin 3-O-beta-D-galactoside + H(+) + UDP => cyanidin + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43325", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine => 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443774", "l": "Trans-homodimerization of Neurofascin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48750", "l": "D-erythrulose + H(+) + NADH => D-threitol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.196", "l": "\"Limit dextrin alpha-1,6-maltotetraose-hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66273", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ATP + H2O => a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018460", "l": "cyclohexanol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59014", "l": "24-methylenecycloartanol + H(+) + S-adenosyl-L-homocysteine => cycloartenol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39093", "l": "(3S)-hydroxydecanedioyl-CoA => (2E)-decenedioyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176116", "l": "Recruitment and activation of Chk1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351208", "l": "Spermidine  => N-acetylated spermidine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.10", "l": "\"Ferric-chelate reductase (NAD(P)H)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41449", "l": "2-oxoglutarate + L-isoleucine + O2 => (4S)-4-hydroxy-L-isoleucine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046574", "l": "glycuronidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58575", "l": "O-acetyl-15alpha-stemmadenine + O2 <=> H2O2 + precondylocarpine acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51850", "l": "8-methylmenaquinol-6 + fumarate => 8-methylmenaquinone-6 + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0015315", "l": "organophosphate:inorganic phosphate antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205118", "l": "TRAF6 polyubiquitinates NRIF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52611", "l": "2-hydroxybutanoate + NADP(+) <=> 2-oxobutanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.142", "l": "\"Limit dextrinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28619", "l": "2-methylbutyronitrile + H(+) + NADPH + O2 => 2-hydroxy-2-methylbutanenitrile + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629365", "l": "NEIL3 recognizes and binds to spiroiminodihydantoin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008137", "l": "NADH dehydrogenase (ubiquinone) activity"}, {"i": "MetaCyc:RXN0-5330"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33486", "l": "an acyl-CoA + ergosterol <=> CoA + ergosteryl ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56625", "l": "2,4,5-trichlorocyclohexa-2,5-dien-1-ol + H2O => 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + chloride + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2263492", "l": "Defective HGSNAT does not acetylate Heparan chain(1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43965", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA => 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625424", "l": "The retrograde IFT train dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29719", "l": "cob(I)alamin(in) = cob(I)alamin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42962", "l": "NADH + 2 oxidized [nitric oxide reductase rubredoxin domain] => H(+) + NAD(+) + 2 reduced [nitric oxide reductase rubredoxin domain]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26206", "l": "4-nitrophenol + H(+) + NADPH + O2 => 4-nitrocatechol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38652", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676168", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20316", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP <=> 1D-myo-inositol hexakisphosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40576", "l": "glutaryl-CoA + H2O => CoA + glutarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63203", "l": "(10bS,4aR)-noroxomaritidine + H(+) + NADPH <=> (10bS,4aR)-oxomaritidine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74726", "l": "Dissociation of insulin from insulin receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034583", "l": "21U-RNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191656", "l": "Closure of gap junction (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66140", "l": "acetyl-CoA + octopamine = CoA + H(+) + N-acetyloctopamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605723", "l": "Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22474", "l": "ADP + D-pantetheine 4'-phosphate + H(+) => (R)-pantetheine + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209199", "l": "CKA is phosphorylated by phosphorylated BSK kinase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174456", "l": "Joining of adjacent Okazaki fragments of the C-strand (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070626", "l": "(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698932", "l": "Assembly of HCMV Procapsid (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13626", "l": "A + H2O + N(6)-dimethylallyladenine => 3-methyl-2-butenal + adenine + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938356", "l": "RMB14 binds RUNX2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.38", "l": "\"FMN reductase (NADPH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36244", "l": "acetate + NADP(+) + trans-anol => NADPH + trans-coumaryl acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42095", "l": "all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34736", "l": "a fatty acyl-CoA + sphinganine => an N-acylsphinganine + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-141046", "l": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4332356", "l": "CAMK2 binds MAP3K7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983152", "l": "Transfer of ubiquitin from E1 to E2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9649108", "l": "HTR3A pentamer binds 5HT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21888", "l": "NADP(+) + OPC-8 = (10Z,15Z)-12-oxophytodienoate + H(+) + NADPH"}, {"i": "EC:1.3.1.42", "l": "\"12-oxophytodienoate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33078", "l": "3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine <=> 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49338", "l": "H2O + spheroiden-2-one => 2,2-dihydroxyspheroidene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41310", "l": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36689", "l": "CoA + H(+) + N-hexadecanoylsphing-4-enine => hexadecanoyl-CoA + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52752", "l": "H2O + isomaltose = beta-D-glucose + D-glucose"}, {"i": "EC:3.2.1.205", "l": "\"Isomaltose glucohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22448", "l": "ATP + pseudouridine = ADP + H(+) + psi-UMP"}, {"i": "EC:2.7.1.83", "l": "\"Pseudouridine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1606839", "l": "Steryl sulfatase hydrolyses sulfate from steroid sulfates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112690", "l": "PTPN11 binds CBL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371435", "l": "Constitutive phosphorylation by GSK3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44451", "l": "an acyl-CoA + H(+) + malonyl-[ACP] <=> a 3-oxoacyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11547", "l": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine <=> H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798257", "l": "PTPRS binds NTRK3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854209", "l": "TBC1D10A binds JFC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39703", "l": "(2E,13Z)-eicosadienoyl-CoA + H(+) + NADPH = (13Z)-eicosenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662986", "l": "MT2A binds copper (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43360", "l": "an N-acylsphinganine + UDP-alpha-D-glucose = an N-acyl-beta-D-glucosyl-(1<->1')-sphinganine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "73.539748874002555", "identifiers": [{"i": "GO:0016823", "l": "hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances"}, {"i": "EC:3.7.1.-", "l": "\"In ketonic substances\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2509838", "l": "ITPA hydrolyses dITP to dIMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30652", "l": "2 H2O + O2 + urate => allantoin + CO2 + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803063", "l": "RNASEs bind bacterial LPS, PGN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139905", "l": "Translocation of activated BAD protein to mitochondria (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49362", "l": "2,2'-dioxospirilloxanthin + H2O => 2',2'-dihydroxy-2-oxospirilloxanthin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66771", "l": "ATP + coproporphyrin I(in) + H2O <=> ADP + coproporphyrin I(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22979", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15438", "l": "a long-chain fatty aldehyde + CoA + NADP(+) => a long-chain fatty acyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65500", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + AH2 + S-adenosyl-L-methionine = 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + A + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805126", "l": "AURKB phosphorylates TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58554", "l": "(16R)-deshydroxymethyl-stemmadenine + formate => 15alpha-stemmadenine intermediate II + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61840", "l": "brassicasterol + UDP-alpha-D-glucose = brassicasterol 3-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698016", "l": "PTPN11:p-STAT5 translocates to nucleus downstream of mutant FLT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702618", "l": "quizartinib-resistant FLT3 mutants don't bind quizartinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417927", "l": "P2Y2 receptor binds ATP and UTP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53020", "l": "a plastoquinone + an L-alpha-amino acid + H2O = a 2-oxocarboxylate + a plastoquinol + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15020", "l": "a phosphate monoester + H2O <=> an alcohol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54411", "l": "1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41665", "l": "dihydrochelirubine + NAD(+) => chelirubine + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35014", "l": "D-fucose(in) + H(+)(in) <=> D-fucose(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22355", "l": "H(+) + L-lysine <=> cadaverine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72631", "l": "Formation of the cap-binding eIF4F complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371527", "l": "HSF1 trimer translocates to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390595", "l": "Calcium Binds Troponin-C (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53879", "l": "a cytidine in tRNA + acetyl-CoA + ATP + H2O <=> ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482770", "l": "Release of platelet secretory granule components (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977228", "l": "Sialyltransferase I can add sialic acid to the T antigen at the alpha 6 position (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8985950", "l": "p-Y649-STAT5A, p-STAT5B dimerizes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2186780", "l": "Degradation of Ub-SMAD7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58810", "l": "AMP + GMP + 2 H(+) => 2',3'-cGAMP + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64269", "l": "emodin anthrone + O2 => emodin + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036458", "l": "hepatocyte growth factor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198621", "l": "AKT phosphorylates caspase-9 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.3.4", "l": "\"NADH oxidase (H(2)O-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64804", "l": "acetyl-CoA + S-(2-aminoethyl)-L-cysteine = CoA + H(+) + S-(2-acetamidoethyl)-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12346", "l": "H(+) + L-glutamyl-tRNA(Glu) + NADPH => (S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432427", "l": "PP1 dephosphorylates phosphorylated TIM (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28525", "l": "D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O <=> D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55153", "l": "H(+) + L-prolyl-[peptidyl-carrier protein] + 2 oxidized [electron-transfer flavoprotein] => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034950", "l": "phenylboronic acid monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404134", "l": "RBP4:atROL binds TTR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40766", "l": "(20S)-ginsenoside Re + H2O <=> (20S)-ginsenoside Rg1 + L-rhamnopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61917", "l": "ATP + fluconazole(in) + H2O => ADP + fluconazole(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875568", "l": "RAPGEF1 activates RAP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40007", "l": "(+)-copalyl diphosphate + H2O = (+)-copalol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607733", "l": "BCL10 binds CARD9 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853800", "l": "ARTN binds RET:GFRA1,GFRA3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42815", "l": "cholesterol + octadecanoyl-CoA <=> cholesteryl octadecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16864", "l": "(S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine <=> (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49984", "l": "H(+) + jasmonate + NADPH + O2 = (1R,2R)-12-hydroxyjasmonate + H2O + NADP(+)"}, {"i": "EC:1.14.13.228", "l": "\"Jasmomic acid 12-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2090079", "l": "GLB1 hydrolyses linker chain(2) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56342", "l": "ent-isokaurene-2beta,3beta-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-isokauren-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168640", "l": "Ubiquitinated IkB is degraded (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989776", "l": "Expression of APOA2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214418", "l": "REL binds to monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38924", "l": "a ubiquinone + H(+) + Na(+)(in) + NADH => a ubiquinol + Na(+)(out) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29792", "l": "ATP + glutathione(out) + H2O => ADP + glutathione(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052657", "l": "guanine phosphoribosyltransferase activity"}, {"i": "KEGG.REACTION:R01229"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114284", "l": "Release of Cytochrome c from mitochondria (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44203", "l": "12-methyloctadecanoate + ATP + CoA <=> 12-methyloctadecanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19888", "l": "(S)-reticuline + O2 <=> (S)-scoulerine + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17813", "l": "D-altronate + NAD(+) = H(+) + keto-D-tagaturonate + NADH"}, {"i": "EC:1.1.1.58", "l": "\"Tagaturonate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22952", "l": "O2 + octanedioyl-CoA = (2E)-octenedioyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.2.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.20", "l": "\"Ribonuclease U(2)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264622", "l": "Cho is acetylated to AcCho by CHAT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48415", "l": "globoside IV3GalNAc-Gb4Cer + H2O <=> globoside Gb4Cer + N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "77.349316285872916", "identifiers": [{"i": "GO:0017022", "l": "myosin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53054", "l": "4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 4-hydroxyestrone + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51993", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] => an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683792", "l": "p-T68-CHEK2 autophosphorylates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62061", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15035", "l": "H2O2 + pyridoxal => O2 + pyridoxine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696358", "l": "TREM,CD300 binds lipids (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52311", "l": "2-hydroxyglutarate + NADP(+) <=> 2-oxoglutarate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.45", "l": "\"Melamine deaminase\""}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0032139", "l": "dinucleotide insertion or deletion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59415", "l": "2-oxosuccinamate + H2O <=> NH4(+) + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018762", "l": "aliphatic nitrilase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45697", "l": "N-(acetyl)-sphing-4-enine-1-phosphate(in) => N-(acetyl)-sphing-4-enine-1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166726", "l": "Activation of MASPs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-453338", "l": "PGYM b dimer:AMP complex <=> PGYM dimer, b form + 2 AMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942302", "l": "MMP13 cleaves OPTC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664879", "l": "ATM:PEX5 binds ATM (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16555", "l": "H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] => aldehydo-D-ribose 5-phosphate + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909738", "l": "SHP1 and SHP2 bind the common beta chain (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20436", "l": "NAD(+) + xylitol <=> D-xylulose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36757", "l": "beta-D-Glc-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48883", "l": "a quinone + CO + H2O <=> a quinol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672980", "l": "Dissociation of RAS:RAF complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730858", "l": "Autophosphorylation of BTK/ITK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442387", "l": "ZIP8 mediates zinc influx into cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41617", "l": "D-ribose 2,5-bisphosphate + H2O => D-ribose 5-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65549", "l": "ganglioside Fuc-GM1 + H2O => alpha-Fuc-(1->2)-beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-Glc + an N-acyl-sphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373734", "l": "Nephrin interacts with Podocin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229138", "l": "MAPKAPK2/3-mediated removal of PRC1.4 complex stimulates p14ARF transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964619", "l": "PAK1 binds ARHGEF6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38758", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201637", "l": "Caspase-mediated cleavage of plectin-1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33036", "l": "2-oxospirilloxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => 2,2'-dioxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43203", "l": "cytidine(1920) in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(1920) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43980", "l": "H(+) + hexadecanoate + NADPH + O2 = 15-hydroxyhexadecanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41241", "l": "N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine => N-acyl (9Z,12Z)-octadecadienoate octadecasphin-4E-enine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66322", "l": "2',3'-cGAMP(in) => 2',3'-cGAMP(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57063", "l": "2''-O-acetyl-ADP-D-ribose + H2O <=> acetate + ADP-D-ribose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9648017", "l": "EML4 binds to microtubules (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429732", "l": "multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2002440", "l": "Removal of fibrillar collagen C-propeptides (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047732", "l": "CDP-abequose epimerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20356", "l": "A + chloride + H(+) + trichloroethene <=> AH2 + tetrachloroethene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18698", "l": "3-(4-hydroxyphenyl)pyruvate + H(+) => (4-hydroxyphenyl)acetaldehyde + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216222", "l": "COS binds to SMO (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112609", "l": "POU5F1 (OCT4), SOX2, NANOG, ZSCAN10, PRDM14, SMAD2, FOXP1-ES bind the POU5F1 (OCT4) promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050354", "l": "triokinase activity"}, {"i": "KEGG.REACTION:R01059"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2990880", "l": "NEK6/NEK7 phosphorylates NUP98 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190258", "l": "FGFR2c binds to FGF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624494", "l": "RAF1 binds p21 RAS:GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14553", "l": "(7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate = 2-oxoglutarate + cephalosporin C"}, {"i": "EC:2.6.1.74", "l": "\"Cephalosporin-C transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669158", "l": "NF2 binds PAK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158860", "l": "SULT1A1 dimer sulfonates NHABP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29440", "l": "Fe(2+)(in) + H(+)(out) => Fe(2+)(out) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49935", "l": "(3E,5Z)-octadienoyl-CoA <=> (2E,5Z)-octadienoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389941", "l": "SHP-1 and SHP-2 bind pBTLA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964561", "l": "The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds MYBL2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352059", "l": "SLC6A15-mediated amino acid uptake (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48582", "l": "[pyruvate, water dikinase] + diphosphate => [pyruvate, water dikinase]-phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52750", "l": "2 isomaltose => alpha-isomaltosyl-(1->3)-isomaltose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37741", "l": "1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoserine + CoA => (9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29790", "l": "ATP + glutathione(in) + H2O <=> ADP + glutathione(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40475", "l": "1,2,3-tributanoylglycerol + H2O = butanoate + dibutanoylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34654", "l": "3-methyl-1,2-didehydro-2,3-dihydrosqualene + S-adenosyl-L-methionine <=> 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42344", "l": "H(+) + NADH + O2 + p-cumate = (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+)"}, {"i": "EC:1.14.12.25", "l": "\"p-cumate 2,3-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187506", "l": "Translocation of p27 to the nucleoplasm (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66863", "l": "dimethylallyl diphosphate + 4 isopentenyl diphosphate <=> (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033915", "l": "mannan 1,2-(1,3)-alpha-mannosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938507", "l": "miR-106a binds RUNX1 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22878", "l": "(R)-mandelate + NH4(+) => (R)-mandelamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141409", "l": "Mad1 binds kinetochore (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44928", "l": "2-oxoheptanedioate + acetyl-CoA + H2O = (R)-trihomocitrate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29797", "l": "ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in) => ATP(in) + H2O(in) + Zn(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013159", "l": "CDC42 GEFs activate CDC42 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15240", "l": "2 [Fe(III)-cytochrome c2] + NADPH <=> 2 [Fe(II)-cytochrome c2] + H(+) + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53139", "l": "(3beta,5alpha,17beta)-3-hydroxy-androstan-17-yl sulfate + NADP(+) <=> 5alpha-dihydrotestosterone sulfate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-888589", "l": "Release of GABA at the synapse (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33207", "l": "ATP + H(+) + L-glutamate + NADPH = ADP + L-glutamate 5-semialdehyde + NADP(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102295", "l": "4-methylumbelliferyl glucoside 6'-O-malonyltransferase activity"}, {"i": "MetaCyc:RXN-12699"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68611", "l": "Formation of ORC(1-5) complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41575", "l": "lipoxin A4 + NAD(+) <=> 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25673", "l": "sucrose + UDP-alpha-D-galactose <=> H(+) + loliose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693536", "l": "ATM phosphorylates MDC1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1467466", "l": "ABCA4 mediates atRAL transport (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13625", "l": "A + H2O + N(6)-dimethylallyladenine = 3-methyl-2-butenal + adenine + AH2"}, {"i": "EC:1.5.99.12", "l": "\"Cytokinin dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48669", "l": "20-hydroxy-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28282", "l": "(S)-beta-bisabolene = (S)-beta-macrocarpene"}, {"i": "EC:5.5.1.17", "l": "\"(S)-beta-macrocarpene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200646", "l": "Cytosolic folate export across the plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192051", "l": "CYP7A1 7-hydroxylates CHOL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034555", "l": "3,3'-dibromobisphenol A reductive dehalogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23583", "l": "prostaglandin H2 <=> prostaglandin I2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110208", "l": "NTHL1 glycosylase mediated recognition and binding of cytosine glycol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38830", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0047545", "l": "2-hydroxyglutarate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25599", "l": "(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate => 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678998", "l": "Endosomal TLRs pass through the Golgi (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19763", "l": "FMN + H2O + NAD(+) => FMN-N(5)-oxide + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672083", "l": "KTN1 binds Kinesin-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103060", "l": "kaempferol 3-rhamnoside 7-O-rhamnosyltransferase activity"}, {"i": "MetaCyc:RXN1F-475"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018713", "l": "3-ketopimelyl-CoA thiolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799466", "l": "TP53I3 dimerizes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-170120", "l": "Translocation of Cdc25B to the cytoplasm (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49576", "l": "AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine"}, {"i": "EC:4.1.99.22", "l": "\"GTP 3',8-cyclase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4093332", "l": "p-EPHB phosphorylates SDC2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351876", "l": "Caspase-mediated cleavage of occludin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672957", "l": "PP2A dephosphorylates KSR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51453", "l": "O2 + reduced [NADPH--hemoprotein reductase] + ursodeoxycholate => beta-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24339", "l": "a carboxylate + ATP + CoA <=> AMP + an acyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45223", "l": "[methyl-Co(III) trimethylamine-specific corrinoid protein] + coenzyme M <=> [Co(I) trimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004353", "l": "glutamate dehydrogenase [NAD(P)+] activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693243", "l": "RHOD translocates to the Golgi membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8856157", "l": "LAG3 (CD233) binds MHC II (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426489", "l": "RISC binds inexactly matching target RNAs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51747", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A <=> a 1,2-diacyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673284", "l": "GTP-bound RAC1 contributes to MAPK8 activation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14597", "l": "a CDP-1,2-diacyl-sn-glycerol + choline = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)"}, {"i": "EC:2.7.8.24", "l": "\"Phosphatidylcholine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60359", "l": "H2O + N-octanoylanthranilate <=> anthranilate + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59953", "l": "2,6-dimethylheptanoyl-CoA + H2O => 2,6-dimethylheptanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709098", "l": "DHFR dimer reduces FOLA to DHF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22796", "l": "ATP + D-hamamelose = ADP + D-hamamelose 2'-phosphate + H(+)"}, {"i": "EC:2.7.1.102", "l": "\"Hamamelose kinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033448", "l": "AGG codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004473", "l": "malate dehydrogenase (decarboxylating) (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687105", "l": "IGF2BP1 represses translation of MAPK4 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429767", "l": "Passive I- efflux mediated by SMCT1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57167", "l": "2-oxoglutarate + L-arginyl-[RCC1 domain-containing protein] + O2 <=> (3R)-3-hydroxy-L-arginyl-[RCC1 domain-containing protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679044", "l": "FKBP1A binds sirolimus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191402", "l": "Reduction of presqualene diphosphate to form squalene (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15557", "l": "ATP + H2O + Ni(2+)(out) = ADP + H(+) + Ni(2+)(in) + phosphate"}, {"i": "EC:7.2.2.11", "l": "\"ABC-type Ni(2+) transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8949580", "l": "F1Fo ATP synthase dimerizes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24141", "l": "guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48511", "l": "cholate + NADP(+) <=> 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42796", "l": "(9Z,12Z)-octadecadienoyl-CoA + cholesterol = cholesteryl (9Z,12Z)-octadecadienoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707516", "l": "FeHM dissociates from MetHb (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381644", "l": "ER calcium channels open in response to activated PKA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75079", "l": "Formation of AT-AC C complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034580", "l": "4-methyloctanoyl-CoA dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39822", "l": "2 [Fe(II)-cytochrome b5] + docosanoate + 2 H(+) + O2 <=> 2-hydroxydocosanoate + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63975", "l": "A + dihydropyriculol <=> AH2 + pyriculol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21675", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine <=> [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10839", "l": "NADPH + O2 + questin <=> demethylsulochrin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709360", "l": "H2O2 reduces MetHb (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37588", "l": "2-oxoglutarate + D-lysine => 6-amino-2-oxohexanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23053", "l": "ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] => ADP + H(+) + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102881", "l": "(+)-beta-barbatene synthase activity"}, {"i": "MetaCyc:RXN-8421"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102551", "l": "homogentisate geranylgeranyl transferase activity"}, {"i": "RHEA:38003", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H(+) + homogentisate = 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate"}, {"i": "EC:2.5.1.116", "l": "\"Homogentisate geranylgeranyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55277", "l": "9-cis-retinol + tetradecanoyl-CoA => 9-cis-retinyl tetradecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23411", "l": "NADP(+) + precorrin-6B <=> 2 H(+) + NADPH + precorrin-6A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53053", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate => 4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5662606", "l": "MT3 binds zinc (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132206", "l": "MASPs activation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810376", "l": "ING2 binds PI5P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59134", "l": "AMP + diphosphate + H(+) + staphyloferrin B => 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32257", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + 2 H(+) + NADPH + NH4(+) => meso-2,6-diaminoheptanedioate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27781", "l": "4-hydroxy-3-all-trans-octaprenylbenzoate + H(+) <=> 2-all-trans-octaprenylphenol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33917", "l": "H2O2 + methylamine + succinate semialdehyde => 4-(methylamino)butanoate + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45439", "l": "H2O + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> H(+) + N-hexadecanoylethanolamine + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1220611", "l": "Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66341", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) + ATP + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003874", "l": "6-pyruvoyltetrahydropterin synthase activity"}, {"i": "MetaCyc:4.2.3.12-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62441", "l": "[(1->4)-alpha-D-galacturonosyl methyl ester](n) => 4-deoxy-6-O-methyl-L-threo-hex-4-enopyranuronate + [(1->4)-alpha-D-galacturonosyl methyl ester](n-1)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371527", "l": "HSF1 trimer translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40620", "l": "H2O + tridodecanoylglycerol => 2,3-didodecanoyl-sn-glycerol + dodecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.56"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37327", "l": "ATP + H2O + L-methionyl-L-alanine(out) = ADP + H(+) + L-methionyl-L-alanine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452091", "l": "Phosphorylation of IL2RB Y338 enables SHC recruitment (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57075", "l": "3-oxoisoapionate 4-phosphate + H(+) <=> CO2 + L-erythrulose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.1.-.-", "l": "\"Catalysing the translocation of hydrons\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24978", "l": "(1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin] => (1S)-1,25-dihydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.-", "l": "\"Carboxylic ester hydrolases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.53"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156930", "l": "GTP-binding activates eEF2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69127", "l": "Formation of the Flap Intermediate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204863", "l": "Interaction of Tie2 with Ang2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174171", "l": "Association of Cyclin A with the APC/C (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28513", "l": "arbutin 6-phosphate + H2O <=> beta-D-glucose 6-phosphate + hydroquinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43557", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14067", "l": "3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O => scyllo-inosose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64343", "l": "(2E,6E)-farnesyl diphosphate + 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one <=> 4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31371", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine = (2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.212", "l": "\"2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20582", "l": "H2O + NAD(+) + NH4(+) => 2 H(+) + hydroxylamine + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29094", "l": "a ubiquinone + 5 H(+)(in) + NADH <=> a ubiquinol + 4 H(+)(out) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015110", "l": "cyanate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40758", "l": "(9Z,12Z)-octadecadienoate + 1-hexadecanoylglycerone 3-phosphate <=> 1-(9Z,12Z)-octadecadienoylglycerone 3-phosphate + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63594", "l": "1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199131", "l": "PVR binds CD226 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5679239", "l": "ULK complex translocates to the ER (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22178", "l": "20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034535", "l": "1,2-dihydroxy-8-methylnaphthalene dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032181", "l": "dinucleotide repeat insertion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371435", "l": "Constitutive phosphorylation by GSK3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42397", "l": "cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine => 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800315", "l": "MST1 binds MST1R (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48974", "l": "ADP + H(+) + phosphate + phosphite(in) => ATP + H2O + phosphite(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32268", "l": "4-aminobutanoate + glyoxylate => glycine + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6784765", "l": "p-Y705-STAT3 dimerizes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54591", "l": "S-adenosyl-L-methionine + uridine in 25S rRNA <=> H(+) + N(3)-methyluridine in 25S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19945", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}, {"i": "EC:2.4.1.201", "l": "\"Alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13861", "l": "D-xylose + NAD(+) = D-xylono-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102511", "l": "pelargonidin 3-O-glucoside 7-O-glucosyltransferase (acyl-glucose dependent) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63021", "l": "(9Z,12Z)-octadecadienamide + H2O => (9Z,12Z)-octadecadienoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.163"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59466", "l": "H(+) + NADPH + octadecanal => NADP(+) + octadecan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665761", "l": "FMNL3 binds RHOC:GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39643", "l": "(2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H(+) + NADPH = (18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17547", "l": "[peroxiredoxin]-S-hydroxy-L-cysteine + [protein]-disulfide + ADP + H(+) + phosphate => [peroxiredoxin]-S-hydroxy-S-oxy-L-cysteine + [protein]-dithiol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657775", "l": "Expression of ANGPTL3 regulated by NR1H2 or NR1H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62761", "l": "4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40677", "l": "2-aminobut-2-enoate + H2O => L-threonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416358", "l": "G alpha (q) inhibits PI3K alpha (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6799350", "l": "Exocytosis of specific granule membrane proteins (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106326", "l": "acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity"}, {"i": "RHEA:56192", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800380", "l": "PTPRD binds IL1RAP-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936412", "l": "RNF125 mediated ubiquitination of DDX58, IFIH1 and MADS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57907", "l": "2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + O2 <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-434650", "l": "MATEs mediate extrusion of xenobiotics (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60666", "l": "NADH + phosphate => H2O + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371467", "l": "SIRT1 deacetylates HSF1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2160851", "l": "HAS1,2,3 mediate the polymerisation of HA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12295", "l": "ATP + L-serine + tRNA(Ser) <=> AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2468040", "l": "Cohesin binds PDS5 and WAPAL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675473", "l": "SH2B binds JAK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015625", "l": "ABC-type ferric hydroxamate transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27661", "l": "2-deoxy-alpha-D-ribose 1-phosphate <=> 2-deoxy-D-ribose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4086223", "l": "Collagen type IX binds integrin alpha11beta1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18380", "l": "ATP + streptomycin <=> ADP + H(+) + streptomycin 3''-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53874", "l": "CDP-D-ribose + diphosphate => CTP + D-ribose 5-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11071", "l": "(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O <=> (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418904", "l": "A1 and A3 receptors bind adenosine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627737", "l": "SLC26A3 does not exchange Cl- for HCO3- (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.16", "l": "\"Versatile peroxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44507", "l": "4-hydroxybenzoate + an all-trans-polyprenyl diphosphate <=> a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036219", "l": "GTP diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420724", "l": "CASR binds Ca2+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693751", "l": "FAAH2 hydrolyses AEA to AA and ETA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928591", "l": "EPH:EFN tetramers oligomerise (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11821", "l": "diphthamide-[translation elongation factor 2] + NAD(+) => H(+) + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046935", "l": "1-phosphatidylinositol-3-kinase regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672011", "l": "p-AMPK:AMP binds the ULK complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417927", "l": "P2Y2 receptor binds ATP and UTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12857", "l": "(2S,3S)-3-methyl-L-aspartate = L-glutamate"}, {"i": "EC:5.4.99.1", "l": "\"Methylaspartate mutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73800", "l": "SAICAR => AICAR + Fumarate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22298", "l": "(1R,2R,3R)-prephytoene diphosphate + diphosphate => 2 (2E,6E,10E)-geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17874", "l": "ATP + cob(III)alamin(out) + H2O => ADP + cob(III)alamin(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139919", "l": "Translocation of BIM to mitochondria (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27341", "l": "AH2 + NH4(+) + O2 = A + H(+) + H2O + hydroxylamine"}, {"i": "EC:1.14.99.39", "l": "\"Ammonia monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40739", "l": "(20S)-ginsenoside Rb2 + 2 H2O = (20S)-ginsenoside C-Y + 2 D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65115", "l": "2-oxoglutarate + aculene D + O2 <=> aculene C + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654224", "l": "Activated FGFR3 binds PLCG1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "70.906311464949411", "identifiers": [{"i": "GO:0004674", "l": "protein serine/threonine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10876", "l": "4-hydroxybenzoate + H(+) = CO2 + phenol"}, {"i": "EC:4.1.1.61", "l": "\"4-hydroxybenzoate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035718", "l": "macrophage migration inhibitory factor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.40", "l": "\"Phytepsin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36916", "l": "(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798031", "l": "TP53 stimulates BTG2 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11853", "l": "phosphate + S-methyl-5'-thioadenosine => adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-418553", "l": "cAMP degradation by Phosphodiesterases (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39863", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol = 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37839", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-168400", "l": "iE-DAP elicits a NOD1 response (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445071", "l": "Reinsertion of L1 into the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65231", "l": "(1S,2S)-1,2-dihydronaphthalene-1,2-diol + NADP(+) <=> H(+) + NADPH + naphthalene-1,2-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59294", "l": "D-galactose + N-octadecanoylsphing-4-enine => beta-D-galactosyl-(1<->1')-N-octadecanoylsphing-4-enine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624956", "l": "PDE6D binds INPP5E (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177922", "l": "EGFR dimerization (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903924", "l": "estradiol binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247839", "l": "Retromer associates with WLS (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38131", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol = 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015541", "l": "secondary active cyanate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018524", "l": "acetophenone carboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19861", "l": "a 16alpha-hydroxysteroid + NAD(+) = a 16-oxosteroid + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50348", "l": "alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] = dolichyl diphosphate + H(+) + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047517", "l": "1,4-beta-D-xylan synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68914", "l": "DNA polymerase alpha:primase binds at the origin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453338", "l": "PGYM b dimer:AMP complex <=> PGYM dimer, b form + 2 AMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49403", "l": "H2O + validoxylamine A 7'-phosphate <=> phosphate + validoxylamine A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177922", "l": "EGFR dimerization (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57361", "l": "H2O + NADH => (6R)-NADHX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0015248", "l": "sterol transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37421", "l": "1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59265", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-dihydroxybenzoyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21653", "l": "2-chlorobenzoate + H(+) + NADH + O2 => catechol + chloride + CO2 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66822", "l": "ADP + H(+) + Mn(2+)(out) + phosphate => ATP + H2O + Mn(2+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174124", "l": "Dephosphorylation of phospho-Cdh1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36143", "l": "(2E)-hexadecenoyl-CoA + H(+) + NADPH = hexadecanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46803", "l": "H(+) + Na(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> Na(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15815", "l": "CoA + N-acetylimidazole => 1H-imidazole + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41209", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + a fatty acid + H(+) => 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110307", "l": "REV1 binds AP-dsDNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114544", "l": "p115-RhoGEF activation of RHOA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202127", "l": "eNOS synthesizes NO (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35840", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA => a cardiolipin + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047195", "l": "diacylglycerol-sterol O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420724", "l": "CASR binds Ca2+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977301", "l": "Histidine is decarboxylated to histamine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182988", "l": "Sprouty lures CBL away from EGFR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784598", "l": "NPPA(124-151) binds NPR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31129", "l": "2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + methanol => 3-O-methylgallate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2467794", "l": "Resolution of sister chromatids (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868071", "l": "Clathrin recruits PIK3C2A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64947", "l": "dCTP + 2 H2O <=> dCMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192051", "l": "CYP7A1 7-hydroxylates CHOL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27452", "l": "a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54637", "l": "(13E)-labda-7,13-dien-15-yl diphosphate => diphosphate + labda-7,13(16),14-triene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696947", "l": "USP47 deubiquitinates POLB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28210", "l": "H2O + L-saccharopine + O2 = (S)-2-amino-6-oxohexanoate + H2O2 + L-glutamate"}, {"i": "EC:1.5.3.18", "l": "\"L-saccharopine oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31029", "l": "beta-D-glucopyranosyl trans-(+)-abscisate + UDP => 2-trans-(+)-abscisate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52864", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31075", "l": "(3S)-3-hydroxydodecanoyl-CoA = (2E)-dodecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551297", "l": "Defective ALG11 does not transfer Man to the N-glycan precursor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102636", "l": "3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine gamma-glutamylcyclotransferase activity"}, {"i": "MetaCyc:RXN-15681"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696275", "l": "RND2 binds GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53860", "l": "7beta-hydroxy-3,12-dioxo-5beta-cholan-24-oate + NADP(+) = dehydrocholate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811427", "l": "COPI vesicle uncoating at the ER (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33262", "l": "4-aminoimidazole + H(+) + 2 H2O <=> N-formimidoylglycine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008786", "l": "allose 6-phosphate isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2870221", "l": "E-selectin binds E-selectin ligand (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23223", "l": "4-chlorobenzoate + ATP + CoA <=> 4-chlorobenzoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10102", "l": "a fatty acid + a sterol + H(+) => a sterol ester + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53941", "l": "O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 => 18-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10824", "l": "(S)-malate + NADP(+) = H(+) + NADPH + oxaloacetate"}, {"i": "EC:1.1.1.299", "l": "\"Malate dehydrogenase (NAD(P)(+))\""}, {"i": "EC:1.1.1.82", "l": "\"Malate dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22882", "l": "L-glutamate + prephenate => 2-oxoglutarate + L-arogenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25169", "l": "6-hydroxyhexan-6-olide => 6-oxohexanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855111", "l": "VLDLR binds PCSK9 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55805", "l": "(R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'-(9Z-octadecenoyl)-3'-sn-glycerol) + H2O => (9Z)-octadecenoate + (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-sn-glycerol) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.26", "l": "\"Rhodotorulapepsin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163213", "l": "Transfer of electrons through the succinate dehydrogenase complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37165", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65227", "l": "(1R,2R)-1,2-dihydronaphthalene-1,2-diol + NADP(+) <=> H(+) + NADPH + naphthalene-1,2-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21919", "l": "2 [Fe(III)cytochrome c550] + an aliphatic amine + H2O <=> 2 [Fe(II)cytochrome c550] + an aldehyde + 2 H(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40521", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140840", "l": "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61989", "l": "cytidine(72) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033524", "l": "TYSND1 cleaves SCP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9611852", "l": "ADRB3 bind ADR,NAd (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29558", "l": "H2O + UDP-alpha-D-glucose <=> alpha-D-glucose 1-phosphate + 2 H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200952", "l": "Nef binds a ternary complex comprising DOCK2 guanine nucleotide exchange factor for small Rho-family GTPase Rac, its cofactor ELMO1, and Rac, and activates Rac through this interaction (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39879", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol = a 1-acyl-sn-glycero-3-phosphoethanolamine + a 2,3-diacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015412", "l": "ABC-type molybdate transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10505", "l": "7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH + O2 => 7alpha,12alpha-dihydroxycholest-4-en-3-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008313", "l": "gurken-activated receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61442", "l": "CoA + H(+) + N-acetyl-S-(2-succino)-L-cysteine => acetyl-CoA + S-(2-succino)-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198314", "l": "DAG stimulates protein kinase C-delta (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27931", "l": "(R)-4-phosphopantoate + ATP + beta-alanine => (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12951", "l": "2-dehydro-3-deoxy-D-fuconate + H2O => D-fuconate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730886", "l": "Phosphorylation of SHC by SYK kinase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382096", "l": "Formation of NR-NCOR Corepressor Complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43324", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001854", "l": "complement component C3d binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633460", "l": "MDM2 binds TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0019958", "l": "C-X-C chemokine binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070403", "l": "NAD+ binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005004", "l": "GPI-linked ephrin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804100", "l": "HMGB1 binds LPS (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33536", "l": "H2O + lanosteryl ester => a carboxylate + H(+) + lanosterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690461", "l": "FKBP1A binds tacrolimus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49866", "l": "(+)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+) => (+)-dehydrodiconiferyl acid + 2 a quinone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3769401", "l": "DKK and KRM bind LRP5/6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24244", "l": "NADP(+) + pseudotropine = H(+) + NADPH + tropinone"}, {"i": "EC:1.1.1.236", "l": "\"Tropinone reductase II\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6807872", "l": "Active ARF recruits coatomer (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000319", "l": "BORA binds PLK1 and AURKA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0048029", "l": "monosaccharide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9006850", "l": "IL21 receptor JAK phosphorylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40138", "l": "(9Z)-tetradecenoyl-CoA + H2O <=> (9Z)-tetradecenoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24666", "l": "H(+) + 2 H2O + 2 L-citrulline + NADP(+) + 2 nitric oxide => 2 N(omega)-hydroxy-L-arginine + NADPH + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11542", "l": "an N-acyl-D-mannosaminolactone + H(+) + NADH => an N-acyl-D-mannosamine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.20"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847537", "l": "RAB43:GTP binds USP8NL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40435", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848930", "l": "PTK6 translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2025890", "l": "Calcineurin binds NFATC1,2,3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849085", "l": "ARHGAP35 binds RHOA:GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389352", "l": "Translocation of Vav1 to CD28 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.-.-", "l": "\"Glycosylases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64034", "l": "a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP + H(+) => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033424", "l": "CCG codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19401", "l": "methanol + NAD(+) = formaldehyde + H(+) + NADH"}, {"i": "EC:1.1.1.244", "l": "\"Methanol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213241", "l": "Formation of nonameric complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0019843", "l": "rRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12887", "l": "beta-D-mannosyl-5''-O-queuosine 5'-phosphate in tRNA(Asp) + GDP + H(+) => GDP-alpha-D-mannose + queuosine 5'-phosphate in tRNA(Asp)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10744", "l": "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) = 3,4-dihydroxybenzoate + CO2 + NADH"}, {"i": "EC:1.3.1.53", "l": "\"(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40154", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.30.2", "l": "\"Serratia marcescens nuclease\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112392", "l": "Resumption of elongation after recovery from pausing (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56289", "l": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12176", "l": "phenylethanolamine + S-adenosyl-L-methionine = H(+) + N-methylphenylethanolamine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.14", "l": "\"2-hydroxy-6-oxonona-2,4-dienedioate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33340", "l": "(4R)-hydroxysphinganine + hexacosanoyl-CoA => CoA + H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48131", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (2E,6E)-farnesyl phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36381", "l": "4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholesta-8,24-dien-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.13.4", "l": "\"Poly(A)-specific ribonuclease\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809254", "l": "MTMR8 binds MTMR9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37432", "l": "12,18-didecarboxysiroheme + 2 AH2 + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + 2 A + 2 acetate + Fe-coproporphyrin III + 2 H(+) + 2 L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031957", "l": "very long-chain fatty acid-CoA ligase activity"}, {"i": "REACT:R-HSA-8875077", "l": "SLC27A3 ligates CoA-SH to VLCFA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39331", "l": "(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H(+) + NADPH = (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9613497", "l": "Unwinding DNA for the nascent transcript (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004481", "l": "methylene-fatty-acyl-phospholipid synthase activity"}, {"i": "RHEA:17549", "l": "1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine = 1-acyl-2-(10-methylene)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.16", "l": "\"Methylene-fatty-acyl-phospholipid synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216133", "l": "Dissociation of CI from COS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168423", "l": "JAK2 phosphorylation of IRS-1/2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358789", "l": "Self-ubiquitination of RNF41 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13575", "l": "[(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP => [(1->4)-alpha-D-galacturonosyl](n) + UDP-alpha-D-galacturonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46362", "l": "1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 [Fe(III)-cytochrome b5] + H2O => 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103010", "l": "gibberellin A53,2-oxoglutarate:oxygen oxidoreductase activity (GA97-forming)"}, {"i": "MetaCyc:RXN-991"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44427", "l": "a fatty acyl-CoA + heptadecasphing-4-enine <=> CoA + H(+) + N-acyl-heptadecasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649726", "l": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008997", "l": "ribonuclease R activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37728", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine => 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59589", "l": "ATP + beta-alanine + L-ornithine => ADP + beta-alanyl-L-ornithine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34228", "l": "5-nitrosalicylate + O2 => 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806732", "l": "GNLY binds the bacterial cell surface (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31753", "l": "7(1)-hydroxychlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => chlorophyllide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694364", "l": "N-glycan glucose trimming of Spike (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43288", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0050735", "l": "N-malonyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10535", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine <=> D-glyceraldehyde 3-phosphate + H2O + L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44244", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102608", "l": "tetracenomycin B3 8-O-methyl transferase activity"}, {"i": "MetaCyc:RXN-15435"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10409", "l": "4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA => 3-oxopristanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802943", "l": "RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62500", "l": "holo-[peptidyl-carrier protein] + L-arginyl-AMP = AMP + H(+) + L-arginyl-[peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450488", "l": "BRF1 Complex recruits RNA degradation activities (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19153", "l": "apigenin 7-O-beta-D-glucoside + UDP-alpha-D-apiose = 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone + H(+) + UDP"}, {"i": "EC:2.4.2.25", "l": "\"Flavone apiosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14161", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)"}, {"i": "EC:1.13.11.53", "l": "\"Acireductone dioxygenase (Ni(2+)-requiring)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162657", "l": "Inactivation of Myt1 kinase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730886", "l": "Phosphorylation of SHC by SYK kinase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047895", "l": "formaldehyde dismutase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53063", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate <=> estrone 4-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977071", "l": "Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37016", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13578", "l": "a wax ester + H2O => a long chain fatty alcohol + a long-chain fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49759", "l": "H(+) + O2 + protoviolaceinate <=> CO2 + H2O + proviolacein"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13102", "l": "4-imidazolone-5-propanoate => H2O + trans-urocanate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51504", "l": "a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D-glucose = a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone + H(+) + UDP"}, {"i": "EC:2.4.1.360", "l": "\"2-hydroxyflavanone C-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28571", "l": "ATP + L-serine => diphosphate + L-seryl-5'-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70486", "l": "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24981", "l": "3-hydroxy-4-methylanthranilate + ATP + H(+) => 3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49775", "l": "glycine + hexacosanoyl-CoA <=> CoA + H(+) + N-hexacosanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64729", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (7S,17S)-dihydroperoxy-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14010", "l": "2 dimethylallyl diphosphate => (R,R)-chrysanthemyl diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-976768", "l": "Factor H binds to C3b (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29548", "l": "H2O + UDP-N-acetyl-alpha-D-glucosamine => 2 H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399977", "l": "AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37523", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine = 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60468", "l": "3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452108", "l": "Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42782", "l": "4 H(+) + N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine => adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16480", "l": "NAD(+) + prostaglandin E1 <=> 15-oxoprostaglandin E1 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850945", "l": "Casein kinase II phosphorylates PTEN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730882", "l": "Phosphorylation of PKC-theta (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29251", "l": "2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668545", "l": "NIK autophosphorylates on T559 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74716", "l": "Insulin binds the insulin receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52766", "l": "(E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate => (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38904", "l": "a sphingomyelin(in) + ATP + H2O => a sphingomyelin(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008411", "l": "4-hydroxybutyrate CoA-transferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034562", "l": "2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15377", "l": "(S)-4,5-dihydroxypentane-2,3-dione + ATP = (2S)-2-hydroxy-3,4-dioxopentyl phosphate + ADP + H(+)"}, {"i": "EC:2.7.1.189", "l": "\"Autoinducer-2 kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11288", "l": "dihydromacarpine + H(+) + O2 = H2O2 + macarpine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24246", "l": "H(+) + NADPH + tropinone => NADP(+) + pseudotropine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5633460", "l": "MDM2 binds TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019237", "l": "centromeric DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17957", "l": "3-oxopropanoate = H2O + propynoate"}, {"i": "EC:4.2.1.27", "l": "\"Acetylenecarboxylate hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604712", "l": "Initial activation of proMMP7 by trypsin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10376", "l": "ATP + Cu(2+)(in) + H2O = ADP + Cu(2+)(out) + H(+) + phosphate"}, {"i": "EC:7.2.2.9", "l": "\"P-type Cu(2+) transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14367", "l": "CO2 + L-aspartate + NH4(+) => 2 H(+) + H2O + N-carbamoyl-L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654409", "l": "Activated FGFR3 binds FRS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58585", "l": "dihydroprecondylocarpine acetate => (-)-tabersonine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109857", "l": "MAP2K1 binds MAPK3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28161", "l": "alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25931", "l": "3-methylquinoline + A + H2O <=> 3-methylquinolin-2(1H)-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22306", "l": "5-dehydro-D-fructose + AH2 => A + D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690877", "l": "Expression of DMRT1 in testis differentiation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6795667", "l": "MDM2 translocates to the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40592", "l": "decanedioyl-CoA + H2O => CoA + decanedioate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42729", "l": "S-adenosyl-L-methionine + uridine(2791) in 21S rRNA => 2'-O-methyluridine(2791) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23882", "l": "N(pros)-phospho-L-histidyl-[protein] + pyruvate => L-histidyl-[protein] + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001758", "l": "retinal dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40800", "l": "2-methylpropanoyl-CoA + H2O => 2-methylpropanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49159", "l": "dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine <=> dTDP-alpha-D-forosamine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38808", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54133", "l": "a ribonucleoside 5'-diphosphate-alpha-D-glucose + D-glucose 6-phosphate => a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61049", "l": "lochnericine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + horhammericine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38344", "l": "(20S)-ginsenoside Rd + H2O => (20S)-ginsenoside Rg3 + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382056", "l": "Crk binds to the active PDGF receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40444", "l": "6-deoxy-6-sulfo-D-fructose + ATP => 6-deoxy-6-sulfo-D-fructose 1-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624668", "l": "CEBPA binds CDKN1A (p21) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50918", "l": "AMP + an aldehyde + diphosphate + NADP(+) => a carboxylate + ATP + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5099899", "l": "WNT5A binds FZD4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665748", "l": "FMNL2 binds RHOC:GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39569", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (11Z,14Z)-eicosadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23210", "l": "(2E)-glutaconyl-CoA + acetate => acetyl-CoA + trans-glutaconate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018747", "l": "RHOQ GEFs activate RHOQ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28321", "l": "scutellarein + UDP-alpha-D-glucuronate <=> scutellarin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25889", "l": "dihydroxyacetone phosphate + iminosuccinate => H(+) + 2 H2O + phosphate + quinolinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005129", "l": "granulocyte macrophage colony-stimulating factor receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75850", "l": "Addition of the third nucleotide on the nascent transcript (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5444511", "l": "Formation of MSH2:MSH3 Complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9650165", "l": "ASIC trimers bind H+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48484", "l": "a propanoate ester + H2O = an aliphatic alcohol + H(+) + propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9725206", "l": "IgE binds FCERI (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45887", "l": "12-methyloctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(11-methylheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46681", "l": "2 [Fe(III)-cytochrome b5] + NADH => 2 [Fe(II)-cytochrome b5] + H(+) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166214", "l": "FA anion flip-flops to the opposite surface (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48198", "l": "reduced [electron-transfer flavoprotein] + trans-2-heptadecenoyl-CoA => H(+) + heptadecanoyl-CoA + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65262", "l": "3-hydroxypentacecilide A => verruculide C epoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58690", "l": "H2O + NAD(+) + rifamycin SV para-naphthoquinone carboxamide => NADH + O2 + rifamycin SV"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49899", "l": "(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate <=> 5,10-dihydrophenazine-1,6-dicarboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36130", "l": "gibberellin A34 + S-adenosyl-L-methionine <=> O-methyl gibberellin A34 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34897", "l": "ADP + H(+) + phosphate + selenite(in) => ATP + H2O + selenite(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23207", "l": "chlorogenate + D-glucarate <=> 2-O-caffeoylglucarate + L-quinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4086410", "l": "CDK1 phosphorylates BORA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9663511", "l": "BIL binds GSTA1, FABP1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0052815", "l": "medium-chain acyl-CoA hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3595176", "l": "Defective CHSY1 does not transfer GalNAc to chondroitin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57976", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose = (20S)-ginsenoside C-K + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43751", "l": "ATP + CoA + hexacosanoate <=> AMP + diphosphate + hexacosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112042", "l": "Opioid binds MOR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10646", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+) => 2-oxo-2H-pyran-4,6-dicarboxylate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16453", "l": "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O = 2-formylbenzoate + pyruvate"}, {"i": "EC:4.1.2.34", "l": "\"4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854303", "l": "TBC1D11 binds RAB6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70479", "l": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45388", "l": "H2O + N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-octadecanoyl-sn-glycero-3-phospho-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14741", "l": "4-methylene-L-glutamine + H2O = 4-methylene-L-glutamate + NH4(+)"}, {"i": "EC:3.5.1.67", "l": "\"4-methyleneglutaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64302", "l": "3-phenylpropanal + L-alanine => 3-phenylpropylamine + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937792", "l": "RUNX3 binds SRC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34187", "l": "(2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32034", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-curcumene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849428", "l": "PTPN1 binds PTK6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373342", "l": "CX3CR1 binds CX3CL1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58845", "l": "(6E)-8-hydroxygeranial + NAD(+) => (6E)-8-oxogeranial + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22870", "l": "chloride + H(+) + S-carboxymethyl-L-cysteine => 3-chloro-L-alanine + thioglycolate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38032", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) => (2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.80"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22990", "l": "acetyl-CoA + CO2 + NADPH => 3-oxopropanoate + CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106158", "l": "glycero-3-phosphocholine acyltransferase activity"}, {"i": "RHEA:58476", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine = a 1-acyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031522", "l": "NR1H2,3 binds the APOE gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47876", "l": "ganglioside GD1b + H2O = ganglioside GM1 + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38021", "l": "1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-decanoylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419049", "l": "ROCK activation by RHO (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64660", "l": "a long-chain fatty acid + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] = a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55798", "l": "H2O + hydroquinone + NAD(+) => H(+) + NADH + O2 + phenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132278", "l": "Cleavage of C5 by C5 convertases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6795473", "l": "PDPK1 phosphorylates SGK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810843", "l": "Envoplakin binds periplakin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011748", "l": "IL9R binds JAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088298", "l": "FOXM1 stimulates CCNB1 transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19619", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17413", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}, {"i": "RHEA:54820", "l": "a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}, {"i": "EC:2.4.1.150", "l": "\"N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57927", "l": "H2O + mutildienyl diphosphate <=> diphosphate + premutilin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000109", "l": "CD320:TCII:Cbl dissociates into CD320 and TCII:Cbl (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "49.009560342201397", "identifiers": [{"i": "GO:0005215", "l": "transporter activity"}, {"i": "REACT:R-HSA-168313", "l": "Virion-associated M2 protein mediated ion infusion (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5622129", "l": "FABP5 binds atRA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49905", "l": "(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H(+) + O2 => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO2 + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029268", "l": "Phosphorylation and activation of PLCG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61462", "l": "a 5-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in RNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102630", "l": "gossypetin 8-methyl ester 3'-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-15536"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047374", "l": "methylumbelliferyl-acetate deacetylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33246", "l": "L-tetrahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-7-(methylsulfanyl)heptanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351871", "l": "Caspase-mediated cleavage of Z0-2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679029", "l": "C-ter TLR7 dimer binds HCQ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24297", "l": "(S)-dihydroorotate + H2O => H(+) + N-carbamoyl-L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8943279", "l": "GGT dimers hydrolyse GSH (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40724", "l": "(9E)-octadecenoyl-CoA + H2O => (9E)-octadecenoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28416", "l": "4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+) => gamma-L-glutamylputrescine + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66621", "l": "5alpha-cholest-7-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => (25S)-Delta7-dafachronate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65781", "l": "2 H(+) + metoxuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-(3-chloro-4-methoxylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46748", "l": "carboxyphosphate + NH4(+) = carbamate + 2 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17189", "l": "ATP + L-phenylalanine = diphosphate + H(+) + N-adenylyl-L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10329", "l": "an L-glycol + NAD(+) => a 2-hydroxycarbonyl + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13992", "l": "alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose <=> alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168947", "l": "Ligand binds to TLR10 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76456", "l": "O-atom dealkylation of dextromethorphan (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54789", "l": "[LarE protein]-L-cysteine + ATP + pyridinium-3,5-dicarboxylate mononucleotide => [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37843", "l": "1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10861", "l": "3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2 => 2-(acetamidomethylene)succinate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389083", "l": "Autophosphorylation of PDGF alpha receptors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47288", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140806", "l": "SERPINC1 binds SERPINC1 activators (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21695", "l": "CDP-glycerol + H2O <=> CMP + 2 H(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047524", "l": "16-hydroxysteroid epimerase activity"}, {"i": "RHEA:15829", "l": "a 16alpha-hydroxysteroid = a 16beta-hydroxysteroid"}, {"i": "EC:5.1.99.2", "l": "\"16-hydroxysteroid epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48279", "l": "H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide <=> a beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64780", "l": "S-benzyl-L-cysteine = 2-aminoprop-2-enoate + benzylthiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29555", "l": "H2O + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + 2 H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45119", "l": "(4R)-ipsdienol + NADP(+) <=> H(+) + ipsdienone + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13585", "l": "ATP + butanoate = ADP + butanoyl phosphate"}, {"i": "EC:2.7.2.7", "l": "\"Butyrate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35186", "l": "5-hydroxythiophene-2-carbonyl-CoA + H2O <=> 4-carboxy-2-thioxobutanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043136", "l": "glycerol-3-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163539", "l": "perilipin:CGI-58 complex -> perilipin + CGI-58 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873917", "l": "Translocation of STAT1 dimer to nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22764", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate"}, {"i": "EC:3.1.3.36", "l": "\"Phosphoinositide 5-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806629", "l": "Formation of tonofilament bundles (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15257", "l": "D-threonine = acetaldehyde + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400459", "l": "Signal peptidase hydrolyzes preproGLP-1 to proGLP-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41579", "l": "dTDP-beta-L-mycarose + erythronolide B <=> 3-O-alpha-L-mycarosylerythronolide B + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58707", "l": "rifampicin hemiaminal <=> rifampicin ortho-naphthoquinone carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47948", "l": "H2O + thiamine phosphate = phosphate + thiamine"}, {"i": "EC:3.1.3.100", "l": "\"Thiamine phosphate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54545", "l": "1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine => 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102433", "l": "phenylalanine 4-hydroxylase (N10-formyl-tetrahydrofolate dependent) activity"}, {"i": "MetaCyc:RXN-13907"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14404", "l": "chlordecone alcohol + NADP(+) <=> chlordecone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046555", "l": "acetylxylan esterase activity"}, {"i": "MetaCyc:3.1.1.72-RXN"}, {"i": "EC:3.1.1.72", "l": "\"Acetylxylan esterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26347", "l": "aldehydo-D-galacturonate + H(+) + NADPH => L-galactonate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58935", "l": "4 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 8 H(+) + malonyl-CoA + 4 NADPH <=> 5 CO2 + 6 CoA + demethylluteothin + 3 H2O + 4 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74734", "l": "Re-integration of insulin receptor into plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31766", "l": "a 2-oxocarboxylate + L-methionine <=> 4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617828", "l": "TRIP11:IFT20 dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.253"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9656947", "l": "OGG1beta translocates to mitochondria (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59931", "l": "erythritol + NADP(+) <=> D-erythrose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693319", "l": "CTRC hydrolyses PRSS1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53771", "l": "allocholate + allodeoxycholoyl-CoA <=> allocholoyl-CoA + allodeoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48199", "l": "H(+) + heptadecanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> reduced [electron-transfer flavoprotein] + trans-2-heptadecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392749", "l": "Transport of L1 into endosomes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783681", "l": "LIF binds LIFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37264", "l": "ATP + H2O + L-alanyl-L-aspartate(out) => ADP + H(+) + L-alanyl-L-aspartate(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686336", "l": "SARS-CoV-1 3a oligomerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3785768", "l": "MRN complex binds DNA double strand breaks (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48230", "l": "a 1-lyso-glycerophospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] => a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018664", "l": "benzoate 4-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61167", "l": "kaempferol + UDP-beta-L-rhamnose <=> H(+) + kaempferol 3-O-alpha-L-rhamnoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55159", "l": "a quinone + glutathione + H(+) + hydrogen sulfide <=> a quinol + S-sulfanylglutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371590", "l": "HSP70 binds to HSP40:nascent protein (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201611", "l": "Caspase-mediated cleavage of Rock-1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2059926", "l": "NPHP4 protein binds LATS proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61374", "l": "4-methylumbelliferone beta-D-glucuronate(out) + ADP + H(+) + phosphate => 4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113429", "l": "Elongating transcript encounters a lesion in the template (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805035", "l": "TP53 binds STK11 and NUAK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65947", "l": "AH2 + CTP + S-adenosyl-L-methionine <=> 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44891", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O <=> 1-O-alkyl-sn-glycero-3-phosphate + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42544", "l": "uridine(32) in tRNA = pseudouridine(32) in tRNA"}, {"i": "EC:5.4.99.28", "l": "\"tRNA pseudouridine(32) synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3782637", "l": "HDAC8 deacetylates histones (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686430", "l": "MUS81 binds EME1, EME2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65273", "l": "chrodrimanin C + H(+) + NADPH + O2 => chrodrimanin H + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57548", "l": "(S)-beta-macrocarpene + O2 + reduced [NADPH--hemoprotein reductase] = [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21000", "l": "1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,2,3,5-tetrahydroxybenzene + 1,3,5-trihydroxybenzene"}, {"i": "EC:1.97.1.2", "l": "\"Pyrogallol hydroxytransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665417", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind GRB2:GAB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050553", "l": "taxadiene synthase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015383", "l": "sulfate:bicarbonate antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928614", "l": "EFNB:GRB4 binds GIT1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19560", "l": "AH2 + O2 + pregna-4,9(11)-diene-3,20-dione <=> 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9645598", "l": "RRAGC,D hydrolyzes GTP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69299", "l": "CDT1 binds geminin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201608", "l": "Caspase-mediated cleavage of alpha adducin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111966", "l": "GRK2 binds CALM1:4Ca2+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205321", "l": "Interaction of KIT and sSCF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50443", "l": "prostaglandin H1 <=> prostaglandin D1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36029", "l": "H(+) + NADH + propanoyl-CoA => CoA + NAD(+) + propanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010329", "l": "auxin efflux transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430347", "l": "MigFilin associates with Filamin and F-actin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-377644", "l": "Release of CSK from SRC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55976", "l": "glutathione + thiosulfate = H(+) + S-sulfanylglutathione + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23107", "l": "D-arabinose 5-phosphate <=> D-ribulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15215", "l": "(R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA => (R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165680", "l": "Formation of active mTORC1 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19136", "l": "2-oxoglutarate + 3,3',5-triiodo-L-thyronine <=> 3,5,3'-triiodothyropyruvate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53391", "l": "5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + UDP-alpha-D-glucuronate <=> 5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805061", "l": "CK2 binds FACT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112430", "l": "Formation of P-TEFb complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939904", "l": "Activated ESR1 binds the RUNX2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33222", "l": "ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> gibberellin A12 + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870461", "l": "RABGGTA and RABGGTB bind (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16497", "l": "adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.181", "l": "\"23S rRNA (adenine(1618)-N(6))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018497", "l": "Estrogen-responsive TFF3 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866269", "l": "ARRB bind GPCRs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1606273", "l": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607722", "l": "Active NIK phosphorylates IKKA dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58095", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25349", "l": "D-tyrosine + tRNA(Tyr) => D-tyrosyl-tRNA(Tyr) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0099095", "l": "ligand-gated anion channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011961", "l": "GREB1 translation is negatively regulated by miR-26A and B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419644", "l": "Transphosphorylation of pLIMK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42284", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50157", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 => N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49496", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + H(+) = 2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.40"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877153", "l": "STARD7 binds PC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5671993", "l": "CIT-3 binds DLG4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381087", "l": "Dimerization of PERK (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730847", "l": "Hydrolysis of PIP2 by PLCG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56112", "l": "2-all-trans-nonaprenylphenol + H(+) + NADPH + O2 = 3-(all-trans-nonaprenyl)benzene-1,2-diol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19337", "l": "2 hydroxylamine + 2 NAD(+) = 2 H(+) + hyponitrous acid + 2 NADH"}, {"i": "EC:1.7.1.5", "l": "\"Hyponitrite reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29945", "l": "2-dehydro-3-deoxy-D-gluconate(out) + H(+)(out) => 2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22323", "l": "2 alpha-D-glucose 1-phosphate + H2O <=> D-maltose + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093342", "l": "SDC2 multimerises (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64410", "l": "H(+)(in) + N-acetylmuramyl-L-alanyl-D-isoglutamine(in) => H(+)(out) + N-acetylmuramyl-L-alanyl-D-isoglutamine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694681", "l": "mRNA5 is translated to protein M (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58664", "l": "(S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol"}, {"i": "EC:1.1.5.13", "l": "\"(S)-2-hydroxyglutarate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604360", "l": "Initial activation of proMMP2 by MMP14 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2002401", "l": "Association of procollagen type XVIII (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102504", "l": "luteolinidin 5-O-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-14424"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684836", "l": "CLEC1B dimer binds PDPN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34124", "l": "3,5,7-trioxododecanoyl-CoA => CoA + H(+) + olivetolate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645220", "l": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687113", "l": "MYC mRNA translation is negatively regulated by miR-34B and C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046571", "l": "aspartate-2-keto-4-methylthiobutyrate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20422", "l": "alpha-maltose 6'-phosphate + H2O => D-glucose + D-glucose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39705", "l": "(13Z)-eicosenoyl-CoA + NADP(+) => (2E,13Z)-eicosadienoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27454", "l": "iodide + L-tyrosine + NADP(+) => 3-iodo-L-tyrosine + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62069", "l": "2-deoxy-D-glucose 6-phosphate + NADP(+) => 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806425", "l": "TP53 stimulates FANCC expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381087", "l": "Dimerization of PERK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102788", "l": "4-coumaroyl-CoA:pelargonidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity"}, {"i": "MetaCyc:RXN-7998"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193702", "l": "Part of the ICD migrates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64712", "l": "1-propanol + NADP(+) = H(+) + NADPH + propanal"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005523", "l": "tropomyosin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798743", "l": "Exocytosis of secretory granule membrane proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034007", "l": "S-linalool synthase activity"}, {"i": "MetaCyc:4.2.3.25-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12590", "l": "ganglioside GM2 (d18:1(4E)) + H(+) + UDP => ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788571", "l": "STAT1,STAT3,STAT6 bind IL13:IL13R type II (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48715", "l": "2 Fe(2+) + 2 H(+) + H2O2 <=> 2 Fe(3+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047152", "l": "methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62753", "l": "H2O + pravastatin lactone => (S)-2-methylbutanoate + H(+) + pravastatin diol lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28112", "l": "5'-chloro-5'-deoxyadenosine + L-methionine => chloride + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20448", "l": "L-arogenate + oxaloacetate <=> L-aspartate + prephenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50592", "l": "13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34795", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O = alpha-D-ribose 1,5-bisphosphate + H(+)"}, {"i": "EC:3.1.4.55", "l": "\"Phosphoribosyl 1,2-cyclic phosphate phosphodiesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37514", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34639", "l": "1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 = H2O + NADP(+) + neopentalenolactone D"}, {"i": "EC:1.14.13.171", "l": "\"Neopentalenolactone D synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70427", "l": "PGM:Mg2+ isomerise G1P to G6P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20533", "l": "H2O + pyridoxal 5'-phosphate = phosphate + pyridoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55108", "l": "3-oxononanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxynonanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035035", "l": "histone acetyltransferase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70573", "l": "argininosuccinate <=> fumarate + arginine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033973", "l": "dCTP deaminase (dUMP-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38293", "l": "(S)-malate + CoA + H(+) => (S)-malyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194678", "l": "CYP51A1 demethylates LNSOL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19764", "l": "FMN-N(5)-oxide + H(+) + NADH <=> FMN + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48335", "l": "a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose <=> a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35039", "l": "spermidine(in) = spermidine(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0005035", "l": "death receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612483", "l": "EGR1,2,3 bind the NAB2 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58166", "l": "7-epi-ent-eudesmane-5,11-diol + diphosphate => (2E,6E)-farnesyl diphosphate + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50465", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) + 8 malonyl-CoA + 16 NADPH => 17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57218", "l": "N(2)-(1-hydroxy-2-oxoethyl)-dGTP => dGTP + glyoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194678", "l": "CYP51A1 demethylates LNSOL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20419", "l": "CO2 + coelenteramide + hnu => coelenterazine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34094", "l": "(5R)-5-phosphooxy-L-lysine + H2O <=> (S)-2-amino-6-oxohexanoate + NH4(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47117", "l": "eicosanoate + glycine => H2O + N-eicosanoylglycinate"}]}
{"type": "biolink:MolecularActivity", "ic": "80.661393760018115", "identifiers": [{"i": "GO:0043495", "l": "protein-membrane adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034335", "l": "DNA negative supercoiling activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15157", "l": "4-hydroxyphenylacetate + H(+) + NADPH + O2 = H2O + homogentisate + NADP(+)"}, {"i": "RHEA:15161", "l": "4-hydroxyphenylacetate + H(+) + NADH + O2 = H2O + homogentisate + NAD(+)"}, {"i": "EC:1.14.13.18", "l": "\"4-hydroxyphenylacetate 1-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683792", "l": "p-T68-CHEK2 autophosphorylates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265959", "l": "Phosphorylation of Chk2 by ATM upon DNA damage (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49336", "l": "2,2-dihydroxyspheroidene = H2O + spheroiden-2-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46837", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22052", "l": "A + H2O + NH4(+) = AH2 + H(+) + hydroxylamine"}, {"i": "EC:1.7.99.1", "l": "\"Hydroxylamine reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371527", "l": "HSF1 trimer translocates to the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005307", "l": "choline:sodium symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871226", "l": "RET binds GFRA1,GFRA2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46038", "l": "dCMP + H(+) + UDP => 2'-deoxycytidine + UTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706328", "l": "Active FLT3 binds to SOCS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29684", "l": "alpha-maltohexaose + phosphate => alpha-D-glucose 1-phosphate + alpha-maltopentaose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11162", "l": "L-aspartate 4-semialdehyde + L-glutamate => 2-oxoglutarate + L-2,4-diaminobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33924", "l": "(1R,4R)-5-oxo-1,2-campholide => [(1R)-2,2,3-trimethyl-2-oxocyclopent-3-en-1-yl]acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29475", "l": "(2E,6E)-farnesyl diphosphate = (+)-cubenene + diphosphate"}, {"i": "EC:4.2.3.63", "l": "\"(+)-cubenene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50282", "l": "(5S)-hydroperoxy-(14R,15S)-epoxy-(6E,8Z,11Z)-eicosatrienoate => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047399", "l": "glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase activity"}, {"i": "RHEA:18045", "l": "6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H2O = alpha-D-glucose 1-phosphate + alpha-D-mannose derivative + H(+)"}, {"i": "EC:3.1.4.51", "l": "\"Glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976734", "l": "Amyloid fibrils have additional components (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350769", "l": "trans-Golgi Network Coat Activation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22201", "l": "S-adenosyl-L-methionine + trans-aconitate => (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57697", "l": "ATP + cob(I)inamide--[corrinoid adenosyltransferase] => adenosylcob(III)inamide + apo-[corrinoid adenosyltransferase] + triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37456", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391168", "l": "SIRP gamma binds CD47 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51397", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + serotonin => CoA + H(+) + N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63605", "l": "[Pyr1]apelin-13 + H2O => [Pyr1]apelin-12 + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15507", "l": "2-formylglutarate + H(+) + NADH => 2-(hydroxymethyl)glutarate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17169", "l": "acetyl-CoA + alpha-D-galactosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate"}, {"i": "EC:2.3.1.276", "l": "\"Galactosamine-1-phosphate N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49497", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + H(+) => 2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62891", "l": "GDP-beta-L-fucose + lactose <=> beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-D-glucose + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018858", "l": "benzoate-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120147", "l": "Formylglycine-generating oxidase activity"}, {"i": "RHEA:51152", "l": "2 a thiol + L-cysteinyl-[sulfatase] + O2 = 3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide"}, {"i": "EC:1.8.3.7", "l": "\"Formylglycine-generating enzyme\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2317332", "l": "PIP3 recruits AKT to the membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102902", "l": "isopimaradienal hydroxylase activity"}, {"i": "MetaCyc:RXN-8538"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102814", "l": "caffeoyl-CoA:delphinidin-3,5,3'-triglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity"}, {"i": "MetaCyc:RXN-8232"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605591", "l": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874083", "l": "p-Y397-PTK2 binds SRC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693540", "l": "MRN activates ATM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10157", "l": "dihydrochelirubine + O2 + reduced [NADPH--hemoprotein reductase] => 12-hydroxydihydrochelirubine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.56", "l": "\"Lytic cellulose monooxygenase (C4-dehydrogenating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43961", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA => a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853405", "l": "TPX2 binds AURKA at centrosomes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24893", "l": "1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) <=> 4-hydroxy-L-glutamate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12899", "l": "(+)-8'-hydroxyabscisate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-cis-(+)-abscisate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70481", "l": "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62566", "l": "(4S)-perillyl alcohol + AH2 => (4S)-limonene + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49625", "l": "ATP + erythritol => ADP + D-erythritol 1-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46597", "l": "NADPH + O2 + rifampicin => 2'-N-hydroxyrifampicin + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41445", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate + O2 => glycine + 2 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853793", "l": "p-5Y-RET complexes bind GRB2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29053", "l": "2 H(+)(out) + menaquinol-8 => 2 H(+)(in) + H2 + menaquinone-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37346", "l": "adenosine 2'-phosphate + H2O <=> adenosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20375", "l": "AMP + diphosphate + propanoyl-CoA => ATP + CoA + propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58258", "l": "ADP-D-ribose + L-seryl-[protein] => H2O + O-(ADP-D-ribosyl)-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51074", "l": "a phenol + a phenyl sulfate => a phenol + a phenyl sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210805", "l": "Removal of miRNA passenger strand (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9609921", "l": "SGTA binds Tail-anchored protein (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23988", "l": "(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate"}, {"i": "EC:2.6.1.83", "l": "\"LL-diaminopimelate aminotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14872", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O <=> acetate + an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449829", "l": "IL11 binds IL11RA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.6"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047999", "l": "hyponitrite reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29007", "l": "H(+)(in) + Mn(2+)(in) = H(+)(out) + Mn(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54281", "l": "2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2 => (3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388809", "l": "CTLA-4 binds B7-1/B7-2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30699", "l": "2-oxoglutarate + beta-alanine = 3-oxopropanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41458", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.14", "l": "\"Cytosol alanyl aminopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198314", "l": "DAG stimulates protein kinase C-delta (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864577", "l": "TFAP2C translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41135", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10809", "l": "(S)-2-hydroxypropylphosphonate + H2O2 => (1R,2S)-epoxypropylphosphonate + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19301", "l": "histamine + S-adenosyl-L-methionine = H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.8", "l": "\"Histamine N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58532", "l": "15alpha-stemmadenine intermediate I + H2O = akuammicine + formate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018110", "l": "histone arginine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483186", "l": "PC is converted to PS by PTDSS1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043750", "l": "phosphatidylinositol alpha-mannosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53983", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791349", "l": "TP53 binds the APAF1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38407", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = (9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679775", "l": "COMT binds COMT Inhibitors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426223", "l": "Cation influx mediated by TRPC3/6/7 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033922", "l": "peptidoglycan beta-N-acetylmuramidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65246", "l": "(2S)-hesperetin 7-O-beta-D-glucoside + H(+) + UDP => (2S)-hesperetin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45252", "l": "tetradecanoate(out) = tetradecanoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20824", "l": "adenosine + ATP = ADP + AMP + H(+)"}, {"i": "EC:2.7.1.20", "l": "\"Adenosine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36651", "l": "8-desmethylnovobiocic acid + S-adenosyl-L-methionine = H(+) + novobiocic acid + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.284", "l": "\"8-demethylnovobiocic acid C(8)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27969", "l": "7,8-dihydroneopterin 3'-triphosphate + H2O <=> 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874078", "l": "PTK2 autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619666", "l": "L-PRX:DRP2 binds dystroglycan and laminin-211 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19016", "l": "dTTP + H2O <=> dTDP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26276", "l": "Co-precorrin-3 + S-adenosyl-L-methionine <=> Co-precorrin-4 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0004675", "l": "transmembrane receptor protein serine/threonine kinase activity"}, {"i": "RHEA:18673", "l": "ATP + L-seryl-[receptor-protein] = ADP + H(+) + O-phospho-L-seryl-[receptor-protein]"}, {"i": "RHEA:44880", "l": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein]"}, {"i": "EC:2.7.11.30", "l": "\"Receptor protein serine/threonine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75080", "l": "Formation of AT-AC A complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54181", "l": "a long-chain fatty aldehyde + holo-[ACP] + NAD(+) => a long-chain fatty acyl-[ACP] + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63535", "l": "angiotensin I + H2O <=> angiotensin-(1-9) + L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30710", "l": "putrescine + pyruvate <=> 4-aminobutanal + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38724", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853762", "l": "RET dimerizes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11105", "l": "N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-methionine => H(+) + hercynine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64974", "l": "dUMP + H(+) + phosphate => dUDP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786092", "l": "IL4:IL4R:JAK2 binds IL2RG:JAK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62294", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2 => (S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4720432", "l": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16537", "l": "(9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate"}, {"i": "EC:3.1.3.76", "l": "\"Lipid-phosphate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084912", "l": "Arresten binds integrin alpha1beta1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36336", "l": "D-glucuronate + H2O + NAD(+) => D-glucarate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050088", "l": "mannose-6-phosphate 6-reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45216", "l": "[methyl-Co(III) dimethylamine-specific corrinoid protein] + coenzyme M = [Co(I) dimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050196", "l": "[phosphorylase] phosphatase activity"}, {"i": "MetaCyc:PHOSPHORYLASE-PHOSPHATASE-RXN"}, {"i": "EC:3.1.3.17", "l": "\"[Phosphorylase] phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43147", "l": "adenosine(22) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052879", "l": "9,12-octadecadienoate 8-hydroperoxide 8S-isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45479", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20663", "l": "2 D-alanine => D-alanyl-D-alanine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951951", "l": "RUNX3 binds EP300 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60418", "l": "H(+) + N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 => diglucosyl-enterobactin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19026", "l": "H2O + L-aspartate + O2 => H2O2 + NH4(+) + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43457", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA => (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482629", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57990", "l": "(20S)-ginsenoside F2 + H(+) + UDP => (20S)-ginsenoside Rh2 + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216069", "l": "Interaction of integrin alphaDbeta2 with fibrin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47187", "l": "5alpha-cholesta-7,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + cholesta-5,7,24-trien-3beta-ol + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0032397", "l": "activating MHC class I receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45164", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39063", "l": "NADP(+) + scyllo-inositol = H(+) + NADPH + scyllo-inosose"}, {"i": "EC:1.1.1.371", "l": "\"Scyllo-inositol 2-dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43382", "l": "L-arginyl-[protein] + phosphate => H2O + N(omega)-phospho-L-arginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21814", "l": "7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1299297", "l": "Activation of THIK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904854", "l": "proteasome core complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209109", "l": "Further phosphorylation of ARM by SGG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373738", "l": "Neurofascin interacts with syntenin-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "71.188186454968573", "identifiers": [{"i": "GO:0016646", "l": "oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"}, {"i": "EC:1.5.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798372", "l": "ATM phosphorylates DYRK2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42859", "l": "1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0039632", "l": "RNA translocase activity involved in viral RNA genome packaging"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031820", "l": "P2Y11 nucleotide receptor binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070738", "l": "tubulin-glycine ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1362416", "l": "Frataxin binds iron (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700168", "l": "Active ALK phosphorylates IRS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60902", "l": "an N(3)-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in RNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30242", "l": "n a quinone + n H(+) + n hydrogen sulfide <=> n a quinol + n sulfur"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21820", "l": "L-homocysteine + S-adenosyl-L-methionine = H(+) + L-methionine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66268", "l": "CoA + nonanoyl-AMP = AMP + H(+) + nonanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419465", "l": "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36408", "l": "ATP + hydrogencarbonate + L-threonine => diphosphate + H2O + L-threonylcarbamoyladenylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18410", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45687", "l": "N-dodecanoyl-sphing-4-enine-1-phosphate(in) <=> N-dodecanoyl-sphing-4-enine-1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33251", "l": "2 sucrose = 6-kestotriose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706350", "l": "FLT3 phosphorylates CBL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44039", "l": "12,13-epoxy-(9Z)-octadecenoate + H2O <=> 12,13-dihydroxy-(9Z)-octadecenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956026", "l": "CUL9:RBX1 ubiquitinates BIRC5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61473", "l": "a sphingoid base + hexadecanoyl-CoA => an N-hexadecanoyl-sphingoid base + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42874", "l": "H(+) + N(4)-bis(aminopropyl)spermidine + S-methyl-5'-thioadenosine => N(4)-aminopropylspermidine + S-adenosyl 3-(methylsulfanyl)propylamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033679", "l": "3'-5' DNA/RNA helicase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000298", "l": "endopolyphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16191", "l": "CO2 + homogentisate => 3-(4-hydroxyphenyl)pyruvate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13129", "l": "cis-4-coumarate + UDP-alpha-D-glucose = 4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP"}, {"i": "EC:2.4.1.209", "l": "\"Cis-p-coumarate glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9639286", "l": "RRAGC,D exchanges GTP for GDP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61311", "l": "(+)-(R)-germacrene A + O2 + reduced [NADPH--hemoprotein reductase] <=> germacra-1(10),4,11(13)-trien-12-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57999", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rh2 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984689", "l": "Kinesin-7 is a dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28775", "l": "dinoflagellate luciferin + O2 = H(+) + H2O + hnu + oxidized dinoflagellate luciferin"}, {"i": "EC:1.13.12.18", "l": "\"Dinoflagellate luciferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42292", "l": "a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]"}, {"i": "EC:2.3.1.274", "l": "\"Phosphate acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38460", "l": "2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + a mycolipenoyl-CoA => 2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649724", "l": "LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033453", "l": "GCU codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53072", "l": "2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48331", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose <=> GDP + H(+) + III(4)-a-Fuc-Lc4Cer(d18:1(4E))"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102827", "l": "galactosylononitol-raffinose galactosyltransferase activity"}, {"i": "MetaCyc:RXN-8282"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24661", "l": "H(+) + L-arginine + NADPH + O2 => H2O + N(omega)-hydroxy-L-arginine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12789", "l": "an alditol + NADP(+) = an aldose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008310", "l": "single-stranded DNA 3'-5' exodeoxyribonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64670", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198714", "l": "ERK5 translocates to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41887", "l": "dodecanoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42408", "l": "(2R)-2-phosphoglycerate + ATP = (2R)-2,3-bisphosphoglycerate + ADP + H(+)"}, {"i": "EC:2.7.2.16", "l": "\"2-phosphoglycerate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10382", "l": "5-phospho-alpha-D-ribose 1-diphosphate + orotate => diphosphate + orotidine 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30004", "l": "alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose => alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8951644", "l": "Release of mature NEDD8 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507719", "l": "p62:MEKK3 binds to TRAF6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014812", "l": "ROBOs bind keratan sulfate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19893", "l": "4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP"}, {"i": "EC:2.7.4.7", "l": "\"Phosphooxymethylpyrimidine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626988", "l": "TNF-alpha:TNFR1 binds NSMAF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671873", "l": "Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28999", "l": "H(+)(out) + homoserine lactone(in) = H(+)(in) + homoserine lactone(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29922", "l": "alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP <=> ADP + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8862184", "l": "USP48 cleaves polyubiquitin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033913", "l": "glucan endo-1,2-beta-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39125", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA => (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428909", "l": "Activated TP receptor binds G-protein  G13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201669", "l": "Beta-catenin translocates to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43701", "l": "(2E,6E)-farnesoate + S-adenosyl-L-methionine => methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5622129", "l": "FABP5 binds atRA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28472", "l": "pyridoxine(out) => pyridoxine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60727", "l": "dodecanal + H2O + NADP(+) <=> dodecanoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102215", "l": "thiocyanate methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15792", "l": "L-xylose + NADP(+) <=> H(+) + L-xylono-1,4-lactone + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804383", "l": "PRMT5 methylates TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877404", "l": "RUNX1 binds the promoter of the CTLA4 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68637", "l": "CDC6 protein is synthesized under the control of E2F transcription factors (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396347", "l": "NOTCH1 Coactivator Complex binds HES1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54488", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043882", "l": "malate:sodium symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66092", "l": "3-phenylpyruvate + L-kynurenine = H2O + kynurenate + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17964", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate <=> H2O + leukotriene A4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9633044", "l": "ESR binds STRN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12591", "l": "ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GM2 (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15597", "l": "a Fe(III)-siderophore(out) + ATP + H2O = a Fe(III)-siderophore(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32382", "l": "(1R,2R,4S)-limonene-1,2-diol + NAD(+) <=> (1R,4S)-1-hydroxylimonen-2-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49335", "l": "2-hydroxyspheroidene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2,2-dihydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210285", "l": "Trans-homophilic interaction of PECAM-1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.374", "l": "\"2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29526", "l": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41357", "l": "bacteriochlorophyll a + 3 NADP(+) => geranylgeranyl-bacteriochlorophyllide a + 3 H(+) + 3 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41294", "l": "H2O + N-dodecanoylsphing-4-enine <=> dodecanoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177926", "l": "Dephosphorylation of PAG by SHP2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182986", "l": "CBL-mediated ubiquitination of CIN85 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034942", "l": "cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29850", "l": "(2E)-tetradecenoyl-CoA <=> (3Z)-tetradecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58677", "l": "NADPH + O2 + rifamycin SV => H2O + NADP(+) + rifamycin SV para-naphthoquinone carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19300", "l": "ATP + beta-alanine + L-histidine <=> ADP + carnosine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32704", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => 8-hydroxycopalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.217", "l": "\"Protodeoxyviolaceinate monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804402", "l": "TP53 binds POU4F1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69068", "l": "RFC dissociates after sliding clamp formation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607737", "l": "BCL10 oligomerizes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57082", "l": "1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione => glutathione + S-methyl-1-thio-D-xylulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652099", "l": "Defective SLC35A2 does not exchange UDP-Gal, UDP-GalNAc for UMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46311", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] <=> 17alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52643", "l": "(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + octanoyl-CoA <=> (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11957", "l": "cholesteryl 3-beta-D-glucoside + H2O => cholesterol + D-glucose"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0043893", "l": "acetate:cation symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52216", "l": "[(1''->2')-ADP-alpha-D-ribose]n + H2O = [(1''->2')-ADP-alpha-D-ribose]n-1 + ADP-D-ribose"}, {"i": "EC:3.2.1.143", "l": "\"Poly(ADP-ribose) glycohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380294", "l": "Loss of C-Nap-1 from centrosomes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58202", "l": "6-oxohexanoate + L-glutamate => 2-oxoglutarate + 6-aminohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977301", "l": "Histidine is decarboxylated to histamine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49624", "l": "ATP + erythritol = ADP + D-erythritol 1-phosphate + H(+)"}, {"i": "EC:2.7.1.215", "l": "\"Erythritol kinase (D-erythritol 1-phosphate-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83677", "l": "C4 deamination of cytidine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45728", "l": "(E)-caffeyl alcohol + NADP(+) = (E)-caffeyl aldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49203", "l": "D-mannose 6-phosphate + H2O + phosphoenolpyruvate <=> 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14269", "l": "2 a quinone + H(+) + NADPH = 2 a 1,4-benzosemiquinone + NADP(+)"}, {"i": "EC:1.6.5.5", "l": "\"NADPH:quinone reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390595", "l": "Calcium Binds Troponin-C (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36159", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 oxidized 2[4Fe-4S]-[ferredoxin] = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685319", "l": "CX3 complex formation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862700", "l": "CMKLR1 binds Resolvin E1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40219", "l": "H2O + malonyl-CoA = CoA + H(+) + malonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29616", "l": "alpha-maltotriose + beta-maltose => alpha-maltotetraose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.1.4", "l": "\"Dihydrolipoyl dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57969", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 8-epi-inunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033978", "l": "phosphonopyruvate hydrolase activity"}, {"i": "MetaCyc:3.11.1.3-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21017", "l": "H2O + L-asparagine => L-aspartate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876246", "l": "InlB-activated MET phosphorylates CBL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26321", "l": "resorcinol + S-adenosyl-L-methionine = 3-methoxyphenol + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.n1", "l": "\"Resorcinol O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362427", "l": "Hh-Np binds GPC5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237119", "l": "Acireductone is oxidized to MOB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-164834", "l": "Enzyme-bound ATP is released (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654651", "l": "Activated FGFR4 binds FRS3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047911", "l": "galacturan 1,4-alpha-galacturonidase activity"}, {"i": "RHEA:14117", "l": "[(1->4)-alpha-D-galacturonosyl](n) + H2O = [(1->4)-alpha-D-galacturonosyl](n-1) + alpha-D-galacturonate"}, {"i": "EC:3.2.1.67", "l": "\"Galacturonan 1,4-alpha-galacturonidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814153", "l": "ADO oxidises 2AET to HTAU (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22441", "l": "UDP-alpha-D-galactose + UDP-N-acetyl-alpha-D-glucosamine => H(+) + UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36260", "l": "a 1-(1-hydroxyalkyl)-sn-glycerol => an aldehyde + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114552", "l": "Thrombin-activated PARs activate G12/13 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40111", "l": "butanoyl-CoA + H2O = butanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20854", "l": "ADP + 2 H(+)(out) + phosphate => ATP + H(+)(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420128", "l": "SRC-1 phosphorylates SHB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27314", "l": "dichlorochromopyrrolate + 6 H(+) + 4 NADH + 4 O2 = 2 CO2 + dichloroarcyriaflavin A + 6 H2O + 4 NAD(+)"}, {"i": "EC:1.13.12.17", "l": "\"Dichloroarcyriaflavin A synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60571", "l": "N-acetyl-L-tryptophan <=> N-acetyl-D-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660753", "l": "SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1028817", "l": "CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18412", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) <=> 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49588", "l": "L-erythrulose 1-phosphate = D-erythrulose 4-phosphate"}, {"i": "EC:5.3.1.33", "l": "\"L-erythrulose 1-phosphate isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698762", "l": "FLT3 ITD- and STAT5-dependent NOX4 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162836", "l": "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848776", "l": "PTK6 phosphorylates DOK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790038", "l": "Expression of HSP90B1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697051", "l": "RTC binds NRTIs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25752", "l": "N-hydroxy-L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602050", "l": "Defective CYP26C1 does not 4-hydroxylate 9cRA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9709547", "l": "ESTG binds ESR2:chaperone complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43240", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39073", "l": "(2E)-dodecenedioyl-CoA + H2O2 => dodecanedioyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-83650", "l": "FasL:Fas binds FADD (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16264", "l": "L-lysyl-[protein] + succinyl-CoA <=> CoA + H(+) + N(6)-succinyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109862", "l": "MAP2K2 phosphorylates MAPK1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75856", "l": "Abortive Initiation Before Second Transition (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22507", "l": "3'-phosphoadenylyl sulfate + quercetin 3-sulfate <=> adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3'-bissulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23266", "l": "15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADPH => (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.6", "l": "\"ABC-type lipid A-core oligosaccharide transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9007447", "l": "E2F6 forms the PRC1L4 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56146", "l": "a quinone + H2O + nitrite => a quinol + nitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27596", "l": "all-trans-nonaprenyl diphosphate + 5 diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + 5 isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070891", "l": "lipoteichoic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46050", "l": "alpha-D-galactosamine 1-phosphate => D-galactosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52862", "l": "a short chain fatty acyl-CoA + AMP + diphosphate => a short-chain fatty acid + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49110", "l": "3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + 2 H(+) + L-methionine => Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189062", "l": "lactose + H2O => D-glucose + D-galactose (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17761", "l": "an aromatic primary alcohol + NADP(+) = an aromatic aldehyde + H(+) + NADPH"}, {"i": "EC:1.1.1.91", "l": "\"Aryl-alcohol dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37963", "l": "galactitol + NAD(+) = D-galactose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870469", "l": "RGGT geranylgeranylates RAB proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39324", "l": "(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27366", "l": "bromide + S-adenosyl-L-methionine => bromomethane + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24562", "l": "CoA + O-acetyl-L-serine => acetyl-CoA + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41157", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-8E-octadecenoate + H(+) => 1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36800", "l": "a ribonucleoside 5'-diphosphate + H2O => a ribonucleoside 5'-phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624112", "l": "CEBPA binds CDK4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9647746", "l": "EML4 trimerizes (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59250", "l": "(E)-4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA => (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + (E)-4-coumaroyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782820", "l": "USP17 deubiquitinates SUDS3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110485", "l": "DTSC1 AND DTSC2 form a complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64366", "l": "(15S)-15-hydroperoxy-prostaglandin E2 => prostaglandin G2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40330", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12189", "l": "2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase]-(R)-N(6)-lipoyl-L-lysine + H(+) => [dihydrolipoyllysine-residue succinyltransferase]-(R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12470", "l": "26-desgluco-avenacoside A + D-glucose => avenacoside A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928576", "l": "RHOA:GTP binds ROCK, activating it (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27659", "l": "2-deoxy-alpha-D-ribose 1-phosphate => 2-deoxy-D-ribose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376122", "l": "DSCAM/DSCAML1 homodimerization (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51369", "l": "glycine + octadecanoyl-CoA => CoA + H(+) + N-octadecanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72691", "l": "Formation of the 43S pre-initiation complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71445", "l": "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417820", "l": "P2Y9 receptor can bind to LPA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804379", "l": "PRMT5 binds TTC5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50470", "l": "19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 9 H2O + 18 NADP(+) => 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 27 H(+) + 9 malonyl-CoA + 18 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13675", "l": "[protein-PII]-uridylyl-L-tyrosine + diphosphate => [protein-PII]-L-tyrosine + UTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46546", "l": "2 [Fe(III)-cytochrome b5] + an N-acylsphing-4-enine + 2 H2O => 2 [Fe(II)-cytochrome b5] + an N-acylsphinganine + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809309", "l": "MTMR6 binds MTMR9 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38511", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64052", "l": "(13Z)-docosenoyl-CoA + (4R)-hydroxysphinganine = CoA + H(+) + N-(13Z-docosenoyl)-4R-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37480", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202453", "l": "Auto-ubiquitination of TRAF6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52434", "l": "2 NH4(+) + pyruvate => (R)-2,3-diaminopropanoate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102910", "l": "dirigent protein activity"}, {"i": "MetaCyc:RXN-8677"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.39", "l": "\"Gluconate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.61", "l": "\"Kexin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44266", "l": "4-hydroxy-6-nonadecylpyran-2-one + 2 CO2 + 3 CoA => eicosanoyl-CoA + 2 H(+) + 2 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37877", "l": "methyl aklanonate + S-adenosyl-L-homocysteine => aklanonate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46077", "l": "(2E)-eicosenoyl-CoA + H(+) + NADH => eicosanoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001641", "l": "group II metabotropic glutamate receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26177", "l": "1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine => 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047751", "l": "cholestenone 5-alpha-reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48978", "l": "CO2 + H2O + NAD(+) + pyocyanin => 5-methyl-phenazine-1-carboxylate + 2 H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862300", "l": "LYZ binds bacterial peptidoglycan (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64914", "l": "a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate => a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990312", "l": "type-II cohesin domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37631", "l": "(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59400", "l": "L-2-aminohexanoate = D-2-aminohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16966", "l": "(2E)-geranyl diphosphate => beta-myrcene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60342", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47251", "l": "2 [Fe(III)cytochrome c] + L-gulono-1,4-lactone <=> 2 [Fe(II)cytochrome c] + 3 H(+) + L-ascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10559", "l": "D-glyceraldehyde 3-phosphate + L-arginine <=> H(+) + N(2)-(2-carboxyethyl)-L-arginine + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0003777", "l": "microtubule motor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28479", "l": "galactarate(in) => galactarate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26396", "l": "all-trans-zeaxanthin + 2 O2 <=> 2 (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420274", "l": "GIP receptor binds gastric inhibitory peptide (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49118", "l": "deoxyviolaceinate + H2O + NADP(+) => H(+) + NADPH + O2 + protodeoxyviolaceinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.55"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848818", "l": "PTK6 phosphorylates CBL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11316", "l": "an aliphatic aldoxime = a nitrile + H2O"}, {"i": "EC:4.99.1.5", "l": "\"Aliphatic aldoxime dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70481", "l": "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51808", "l": "(9Z)-octadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z)-octadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204392", "l": "Basigin binds MCT1, MCT3 and MCT4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429441", "l": "SYK activation by SRC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25436", "l": "(2E,6E)-farnesyl diphosphate = (E,R)-alpha-bisabolene + diphosphate"}, {"i": "EC:4.2.3.38", "l": "\"Alpha-bisabolene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57833", "l": "5-oxopentanoate + H2O + NADP(+) => glutarate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938815", "l": "RNF152 polyubiquitinates RRAGA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420121", "l": "SFKs phosphorylate PLCG1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21205", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol => a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44094", "l": "AMP + diphosphate + nonadecanoyl-CoA => ATP + CoA + nonadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37012", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64434", "l": "H(+)(in) + L-alanyl-L-prolylglycine(in) => H(+)(out) + L-alanyl-L-prolylglycine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32970", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> a fatty acid + H(+) + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51763", "l": "a 2-acyl-4,6-diprenylphloroglucinol + dimethylallyl diphosphate <=> a 2-acyl-4,6,6-triprenylphloroglucinol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "77.690207805941611", "identifiers": [{"i": "GO:0015605", "l": "organophosphate ester transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190245", "l": "FGFR1b binds to FGF (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158860", "l": "SULT1A1 dimer sulfonates NHABP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10323", "l": "trans-3-hydroxy-L-proline <=> 1-pyrroline-2-carboxylate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56774", "l": "2 A + all-trans-(3S,3'S)-astaxanthin + 3 H2O => 2 AH2 + all-trans-adonixanthin + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.31", "l": "\"3-hydroxyisobutyrate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873927", "l": "Release of STAT1 dimer from active receptor unit (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50625", "l": "acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O => a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31097", "l": "(2E)-2-methylpropenoyl-CoA + AH2 => 2-methylpropanoyl-CoA + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665748", "l": "FMNL2 binds RHOC:GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41903", "l": "H(+) + malonyl-[ACP] + tetradecanoyl-[ACP] <=> 3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8856945", "l": "PP2A methylation by LCMT1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1980044", "l": "NOTCH1 binds JAG2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26295", "l": "1'-hydroxyversicolorone + H2O + NADP(+) => (1'S,5'S)-averufin + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939670", "l": "RUNX2:CBFB binds the ITGA5 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63701", "l": "mycophenolate + UDP-alpha-D-glucuronate => mycophenolic acid O-acyl-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905763", "l": "MTREC complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41619", "l": "D-ribose 2,5-bisphosphate + H2O <=> D-ribose 5-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36825", "l": "CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate => 1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37777", "l": "1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA => a 1-acyl-sn-glycero-3-phosphoethanolamine + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35406", "l": "(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+) <=> (3R)-vestitone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159868", "l": "Furin cleaves pro-factor VII to factor VII (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42668", "l": "L-rhamnofuranose + NADP(+) = H(+) + L-rhamnono-1,4-lactone + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14845", "l": "L-aspartate 4-semialdehyde + pyruvate = (S)-2,3-dihydrodipicolinate + H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102576", "l": "3-oxo-palmitoyl-ACP hydrolase activity"}, {"i": "MetaCyc:RXN-15282"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54798", "l": "an (R)-2-alkyl-3-oxoalkanoate + H(+) + NADPH => a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016432", "l": "tRNA-uridine aminocarboxypropyltransferase activity"}, {"i": "MetaCyc:2.5.1.25-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14780", "l": "AMP + H(+) + H2O <=> IMP + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675947", "l": "TNFSF18 binds TNFRSF18 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20155", "l": "ADP + beta-L-arabinose 1-phosphate + H(+) => ATP + L-arabinose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450550", "l": "PKCalpha phosphorylates HuR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18511", "l": "2 H2O + NAD(+) => H(+) + H2O2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23607", "l": "kievitone hydrate <=> H2O + kievitone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35524", "l": "H(+) + N-ethylmaleimide + NADPH => N-ethylsuccinimide + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64865", "l": "ITP + oxaloacetate => CO2 + IDP + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031728", "l": "CCR3 chemokine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11514", "l": "H(+) + salicin + UDP => salicyl alcohol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12124", "l": "4-coumaroyl-CoA + shikimate = CoA + trans-4-coumaroylshikimate"}, {"i": "EC:2.3.1.133", "l": "\"Shikimate O-hydroxycinnamoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604264", "l": "ADAM10 cleaves NOTCH4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-377644", "l": "Release of CSK from SRC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29866", "l": "AMP + GTP <=> ADP + GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668417", "l": "cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34683", "l": "alpha-D-ribose 1-methylphosphonate 5-triphosphate + H2O = alpha-D-ribose 1-methylphosphonate 5-phosphate + diphosphate + H(+)"}, {"i": "EC:3.6.1.63", "l": "\"Alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53205", "l": "17beta,19-dihydroxy-3-oxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] => 17beta-hydroxy-3,19-dioxo-5alpha-androstanone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41784", "l": "asialo-GM1a ganglioside (d18:1(4E)/18:0) + CMP-N-acetyl-beta-neuraminate = CMP + ganglioside GM1 (d18:1(4E)/18:0) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810643", "l": "EPPIN protein complex binds bacteria (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2428922", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070182", "l": "DNA polymerase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21932", "l": "S-adenosyl-L-methionine = homoserine lactone + S-methyl-5'-thioadenosine"}, {"i": "EC:2.5.1.4", "l": "\"Adenosylmethionine cyclotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35546", "l": "3-phosphooxypyruvate + H2O <=> 3-hydroxypyruvate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000112", "l": "Endosomal TCII:Cbl translocates to lysosome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59232", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = diphosphate + hydropyrenol"}, {"i": "EC:4.2.3.202", "l": "\"Hydropyrenol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23841", "l": "3-(2,3-dihydroxyphenyl)propanoate + O2 => (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50146", "l": "(9Z)-hexadecenoate + ethanol + H(+) => ethyl (9Z)-hexadecenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17129", "l": "ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate"}, {"i": "EC:6.3.5.3", "l": "\"Phosphoribosylformylglycinamidine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60525", "l": "5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine => 5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66664", "l": "ATP + coproporphyrin III(in) + H2O = ADP + coproporphyrin III(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3560789", "l": "Defective SLC26A2 does not cotransport extracellular SO4(2-), H+ to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.93"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28749", "l": "NH4(+)(out) => NH4(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218806", "l": "FYN autophosphorylates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35405", "l": "(3R)-vestitone + H(+) + NADPH => (3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64965", "l": "dUTP + 2 H2O => dUMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63471", "l": "all-trans-octaprenol + ATP <=> ADP + all-trans-octaprenyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49864", "l": "(+)-dehydrodiconiferyl acid + 2 a quinone + H2O = (+)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944233", "l": "Association of procollagen type XIX (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6795667", "l": "MDM2 translocates to the cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102917", "l": "(S)-reticuline 7-O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22536", "l": "(S)-tetrahydrocolumbamine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + tetrahydropalmatine"}, {"i": "EC:2.1.1.89", "l": "\"Tetrahydrocolumbamine 2-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031993", "l": "light transducer activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22901", "l": "(R)-acetoin + NAD(+) => diacetyl + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16385", "l": "4-hydroxybenzoate + 2 H(+) + NADPH + O2 = CO2 + H2O + hydroquinone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51515", "l": "H2O + oxamate <=> NH4(+) + oxalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60789", "l": "gibberellin A24 + H(+) + O2 => CO2 + gibberellin A9 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953430", "l": "PXMP2 trimer transports glycolate from cytosol to peroxisomal matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38946", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799815", "l": "TP53 family members bind the FAS gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11796", "l": "ecdysone + O2 = 3-dehydroecdysone + H2O2"}, {"i": "EC:1.1.3.16", "l": "\"Ecdysone oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372843", "l": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43721", "l": "juvenile hormone III carboxylate + S-adenosyl-L-methionine => juvenile hormone III + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799350", "l": "Exocytosis of specific granule membrane proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9674529", "l": "AAMP binds to TBXA2R (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14666", "l": "guanine + H(+) + H2O => NH4(+) + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13522", "l": "(R)-lactate + 2 [Fe(III)cytochrome c] => 2 [Fe(II)cytochrome c] + 2 H(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901691", "l": "proton binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372542", "l": "Loading of dopamine into synaptic veiscles (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36449", "l": "ADP + glycyl-L-proline(in) + H(+) + phosphate => ATP + glycyl-L-proline(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50721", "l": "FMNH2 + methanesulfinate + O2 => FMN + H(+) + H2O + methanesulfonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17172", "l": "acetyl-CoA + alpha-D-galactosamine 1-phosphate <=> CoA + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983150", "l": "Proteasomal cleavage of substrate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51687", "l": "(2E,6E)-farnesyl phosphate + CTP <=> (2E,6E)-farnesyl diphosphate + CDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442387", "l": "ZIP8 mediates zinc influx into cells (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31389", "l": "alpha-amyrin => (S)-2,3-epoxysqualene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32481", "l": "3,5-diiodo-L-tyrosine + H(+) + 2 NADPH => 2 iodide + L-tyrosine + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009941", "l": "RNASEL cleaves viral ssRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62913", "l": "H(+) + NADH + O2 + toralactone => 1-(3,4,5-trihydroxy-7-methoxynaphthalen-2-yl)propan-2-one + CO2 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21083", "l": "ATP + H2O + L-methionine <=> diphosphate + phosphate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204392", "l": "Basigin binds MCT1, MCT3 and MCT4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58023", "l": "6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) <=> eupatolide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18666", "l": "(2R)-3-phospho-glyceroyl phosphate + [phosphate](n) => (2R)-3-phosphoglycerate + [phosphate](n+1)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15553", "l": "1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate"}, {"i": "EC:3.1.3.57", "l": "\"Inositol-1,4-bisphosphate 1-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49886", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45296", "l": "a sphingosylphosphocholine + H2O = a sphingoid base + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57663", "l": "(+)-valencene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (+)-nootkatone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700149", "l": "Active ALK binds PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65942", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP + H(+) => (R)-glycerate + GDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047504", "l": "(-)-menthol dehydrogenase activity"}, {"i": "MetaCyc:--MENTHOL-DEHYDROGENASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852337", "l": "GTSE1 binds TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26241", "l": "geranylgeranyl diphosphate = diphosphate + elisabethatriene"}, {"i": "EC:4.2.3.41", "l": "\"Elisabethatriene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851988", "l": "BTN2A2 binds T cell surface (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50617", "l": "NADP(+) + nonan-2-one => (3E)-nonen-2-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19608", "l": "a chlorophyll + H2O <=> a chlorophyllide + H(+) + phytol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951644", "l": "Release of mature NEDD8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16210", "l": "Co-precorrin-8X => cob(II)yrinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446089", "l": "BP180 interacts extracellularly with Laminin 332 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36910", "l": "(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + malonyl-CoA <=> (13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114684", "l": "Phosphorylation of Syntaxin-4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592371", "l": "Initial activation of proMMP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374298", "l": "Opioid receptors bind opioid peptides (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55692", "l": "an inositol-1-phosphoceramide + H2O = 1D-myo-inositol 1-phosphate + an N-acyl-sphingoid base + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29282", "l": "H(+) + menaquinol-8 + trimethylamine N-oxide <=> H2O + menaquinone-8 + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18074", "l": "(S)-dihydroorotate + A => AH2 + orotate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399978", "l": "Protein kinase C, alpha type phosphorylates MARCKS (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36770", "l": "2-hydroxytetracosenoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxytetracosenoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390929", "l": "HTR1 and 5A receptors can bind serotonin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24970", "l": "H2O + 2 oxidized [adrenodoxin] + secalciferol => calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031855", "l": "oxytocin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213239", "l": "Formation of MHC II alpha beta heterodimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690493", "l": "RHOB binds effectors on endosomes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39828", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + tetracosanoate => 2-hydroxytetracosanoate + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9615249", "l": "ARBs bind AGRT1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33413", "l": "(S)-malyl alpha-D-glucosaminide + acetate => (S)-malyl N-acetyl-alpha-D-glucosaminide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33618", "l": "ATP + CoA + octadecanoate <=> AMP + diphosphate + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56789", "l": "apo-[corrinoid adenosyltransferase] + cob(II)alamin => cob(II)alamin--[corrinoid adenosyltransferase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046863", "l": "ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32743", "l": "L-homocysteine + O-acetyl-L-serine = acetate + H(+) + L,L-cystathionine"}, {"i": "EC:2.5.1.134", "l": "\"Cystathionine beta-synthase (O-acetyl-L-serine)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43757", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005544", "l": "calcium-dependent phospholipid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134914", "l": "Beta-catenin migrates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64185", "l": "H2O + N-(9Z-octadecenoyl)-L-tyrosine => (9Z)-octadecenoate + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55340", "l": "(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol = 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31412", "l": "a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202453", "l": "Auto-ubiquitination of TRAF6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61408", "l": "ATP + N(6)-(D-erythrulosyl)-L-lysine = ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869568", "l": "NPM1 binds TFAP2A homodimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004798", "l": "thymidylate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15258", "l": "D-threonine => acetaldehyde + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64569", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one => ilicicolin H"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694583", "l": "ABHD4 hydrolyses NAPE (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65276", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 2alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14766", "l": "coelenterazine h + O2 => CO2 + excited coelenteramide h monoanion + H(+) + hnu"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400434", "l": "FFAR1 binds fatty acids (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53748", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose = a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6793666", "l": "MDM2 translocates to the nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.94"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811412", "l": "Active ARF recruits coatomer to the Golgi (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0031559", "l": "oxidosqualene cyclase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53470", "l": "(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine + cholesterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64078", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+) => 3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30089", "l": "2-oxoglutarate + FADH2 => (S)-2-hydroxyglutarate + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57164", "l": "2-oxoglutarate + L-arginyl-[RCC1 domain-containing protein] + O2 = (3R)-3-hydroxy-L-arginyl-[RCC1 domain-containing protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450975", "l": "isocitrate <=> citrate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61461", "l": "a cytidine in RNA + S-adenosyl-L-methionine => a 5-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6791109", "l": "GADD45A binds PCNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60054", "l": "a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H2O + NAD(+) => a 3beta-hydroxy-4,4-dimethylsteroid + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56114", "l": "3-(all-trans-nonaprenyl)benzene-1,2-diol + H2O + NADP(+) => 2-all-trans-nonaprenylphenol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15074", "l": "3-D-glucuronosyl-N(2),6-disulfo-beta-D-glucosamine + H2O => D-glucuronate + N(2),6-disulfo-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211164", "l": "AKT phosphorylates FOXO1A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26061", "l": "[methyl-Co(III) methylamine-specific corrinoid protein] + NH4(+) => [Co(I) methylamine-specific corrinoid protein] + H(+) + methylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51605", "l": "2 H(+) + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin] => 4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786621", "l": "TRMT10A methylates guanosine-9 in tRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201611", "l": "Caspase-mediated cleavage of Rock-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44519", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O <=> (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60140", "l": "dodecanoyl-CoA + H(+) + malonyl-CoA = 3-oxotetradecanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38304", "l": "2-amino-2-deoxy-D-gluconate 6-phosphate => 2-dehydro-3-deoxy-6-phospho-D-gluconate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53614", "l": "CDP-D-ribulose + diphosphate => CTP + D-ribulose 5-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694082", "l": "XK:KEL:Zn2+ cleaves EDN3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166214", "l": "FA anion flip-flops to the opposite surface (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21451", "l": "16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] <=> 16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15943", "l": "acetate + L-ornithine => H2O + N(2)-acetyl-L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75850", "l": "Addition of the third nucleotide on the nascent transcript (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449117", "l": "TXLNA (IL14) binds syntaxin1A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008666", "l": "2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371385", "l": "TNF-alpha is cleaved by ADAM17 (TACE) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43541", "l": "ATP + L-seryl-[isocitrate dehydrogenase] => ADP + H(+) + O-phospho-L-seryl-[isocitrate dehydrogenase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18624", "l": "2-oxoglutarate + a (2S)-flavan-4-one + O2 <=> a (2R,3R)-dihydroflavonol + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60056", "l": "a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H(+) + NADH + O2 = a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + 2 H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0016004", "l": "phospholipase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52945", "l": "cholate + UDP-alpha-D-glucuronate => choloyl-24-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46301", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 2-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928624", "l": "EPHBs bind EFNBs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349626", "l": "Integrin alpha2beta1 binds laminin-332 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53552", "l": "(9S,10R)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9S,10R)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55755", "l": "2 CO2 + coenzyme B + coenzyme M + 2 reduced [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 formate + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65662", "l": "AH2 + calcidiol => A + calciol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008353", "l": "RNA polymerase II CTD heptapeptide repeat kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44551", "l": "an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an (omega-1)-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188002", "l": "Rab5-mediated recruitment of class III PI3K to TLR9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018807", "l": "RAC3 GDIs block activation of RAC3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37536", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63905", "l": "2 3-phenylpyruvate + H(+) => H2O + phenguignardate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45221", "l": "[methyl-Co(III) trimethylamine-specific corrinoid protein] + coenzyme M => [Co(I) trimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30140", "l": "H2O + octadecanoyl-CoA => CoA + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55070", "l": "a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 12-oxojasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42191", "l": "3beta-hydroxy-5alpha-androstan-17-one + NAD(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65648", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(28-hydroxyoctacosanoyl)-sphing-4-enine = a diacylglycerol + N-(28-(9Z,12Z-octadecadienoyloxy)-octacosanoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019155", "l": "3-(imidazol-5-yl)lactate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199910", "l": "MSK1 activates ATF1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61637", "l": "ATP + CoA + isophthalate => AMP + diphosphate + isophthalyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429714", "l": "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2214324", "l": "Collagen type VII dimerization (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112037", "l": "Inactivation of PLC beta (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52204", "l": "butachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = butyl formate + H2O + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.15.23", "l": "\"Chloroacetanilide N-alkylformylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43533", "l": "a ribonucleoside 3',5'-bisphosphate + H2O => a ribonucleoside 5'-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374899", "l": "Release of noradrenaline  at the synapse (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61426", "l": "cis-cis-nepetalactone + H(+) + NADH => cis-cis-nepetalactol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28194", "l": "(S)-3-sulfolactate + NAD(+) = 3-sulfopyruvate + H(+) + NADH"}, {"i": "EC:1.1.1.310", "l": "\"(S)-sulfolactate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450348", "l": "Activated human JNKs migrate to nucleoplasm (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48940", "l": "an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid"}, {"i": "EC:3.4.13.19", "l": "\"Membrane dipeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63139", "l": "adenosylcob(III)alamin + apo--[alkylcobalamin reductase] + glutathione <=> cob(I)alamin--[alkylcobalamin reductase] + H(+) + S-adenosylglutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164377", "l": "Activated Adenylate cyclase catalyses cAMP synthesis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15709", "l": "kaempferol + UDP-alpha-D-galactose = H(+) + kaempferol 3-O-beta-D-galactoside + UDP"}, {"i": "EC:2.4.1.234", "l": "\"Kaempferol 3-O-galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.10", "l": "\"Oligo-1,6-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2129375", "l": "Elastin cross-linking by lysyl oxidase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60120", "l": "(2E,6E)-farnesyl diphosphate + S-adenosyl-L-methionine = H(+) + pre-sodorifen diphosphate + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.363", "l": "\"Pre-sodorifen synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35128", "l": "L-alanyl-D-glutamate(out) => L-alanyl-D-glutamate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11055", "l": "4-aminobenzoate + 2 H(+) + NADH + O2 <=> 4-aminophenol + CO2 + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51494", "l": "all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58051", "l": "2-O-sulfo-alpha,alpha-trehalose + octadecanoyl-CoA <=> 2-O-sulfo-2'-O-octadecanoyl-alpha,alpha-trehalose + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29856", "l": "H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine => D-alanine + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21479", "l": "[(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->3)-beta-D-glucosyl](n+1) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010313", "l": "phytochrome binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39587", "l": "3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70510", "l": "LDH tetramer oxidises LACT to PYR (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876472", "l": "NPC2 binds CHOL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56375", "l": "3,4-dihydroxybenzoate + bromide + 2 H(+) + NADPH + O2 <=> 3-bromo-4,5-dihydroxybenzoate + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028598", "l": "Phosphorylation of YAP by LATS1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43196", "l": "adenosine(4) in tRNA(His) + S-adenosyl-L-methionine = 2'-O-methyladenosine(4) in tRNA(His) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12109", "l": "L-arginyl-[histone] + S-adenosyl-L-methionine => H(+) + N(omega)-methyl-L-arginyl-[histone] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32070", "l": "8-oxoguanine + H(+) + H2O <=> NH4(+) + urate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018638", "l": "toluene 4-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418456", "l": "cGMP is degraded by PDEs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53517", "l": "1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol => (11Z,14Z,17Z-eicosatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60187", "l": "ATP + D-glucose(out) + H2O <=> ADP + D-glucose(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62169", "l": "H2O + N,N'-diacetylchitobiose => acetate + beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14458", "l": "glyoxylate + H2O + pentanoyl-CoA => 3-propylmalate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168848", "l": "tBID binds to inactive BAK protein (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1454928", "l": "ABCG4 may mediate cholesterol efflux (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668714", "l": "RAC1:GTP binds NOX1 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.30"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31713", "l": "11-oxo-beta-amyrin + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => beta-amyrin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33270", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + 2 H2O + meso-2,6-diaminoheptanedioate + NADP(+) <=> 2 (S)-2-amino-6-oxoheptanedioate + NADPH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31939", "l": "2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + O2 + reduced [NADPH--hemoprotein reductase] = DIBOA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.110", "l": "\"2-hydroxy-1,4-benzoxazin-3-one monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9667965", "l": "ANKLE2 binds PP2A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34909", "l": "molybdate(out) => molybdate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43991", "l": "(2E,6E)-farnesyl diphosphate + H(+) + NADPH + O2 <=> (2E,6E)-omega-hydroxy-farnesyl diphosphate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.n3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10386", "l": "beta-cyclopiazonate + diphosphate => cyclo-acetoacetyl-L-tryptophan + dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12777", "l": "2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + chemical entity"}, {"i": "EC:1.17.3.1", "l": "\"Pteridine oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63381", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => a 1-O-alkyl-2-acetyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5159250", "l": "ATF7IP binds SETDB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62555", "l": "beta-D-glucosylceramide + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53646", "l": "(+)-corvol ether B + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34062", "l": "agroclavine + NADP(+) <=> didehydroagroclavine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047618", "l": "acylagmatine amidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56528", "l": "chloride + D-tryptophan + FADH2 + O2 = 6-chloro-D-tryptophan + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37453", "l": "1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + eicosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690701", "l": "SHP1 binds p-CD22 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008345", "l": "RUNX2-P1 binds RUNX2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51875", "l": "dimethylallyl diphosphate + umbelliferone <=> diphosphate + osthenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36998", "l": "(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50272", "l": "(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O = resolvin E1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23256", "l": "adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine = adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate"}, {"i": "EC:6.3.5.10", "l": "\"Adenosylcobyric acid synthase (glutamine-hydrolyzing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201717", "l": "CSNK2-mediated phosphorylation of DVL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59255", "l": "(E)-3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate <=> (E)-3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53325", "l": "2-glyceryl-prostaglandin H2 => 2-glyceryl-prostaglandin E2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37634", "l": "(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25645", "l": "(2R,5R)-isomenthone + NADP(+) = (R)-pulegone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917693", "l": "ESCRT Disassembly (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209738", "l": "VD3 binds GC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30379", "l": "(2E,6E)-farnesyl diphosphate = (+)-beta-chamigrene + diphosphate"}, {"i": "EC:4.2.3.78", "l": "\"Beta-chamigrene synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033405", "l": "UCU codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023538", "l": "MECP2 binds PTPN1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53258", "l": "7alpha,8alpha-epoxy-5alpha-cholestan-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5alpha-cholest-7-en-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26551", "l": "(S)-piperazine-2-carboxamide + H2O => (S)-piperazine-2-carboxylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043727", "l": "5-amino-4-imidazole carboxylate lyase activity"}, {"i": "RHEA:10792", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2"}, {"i": "EC:4.1.1.21", "l": "\"Phosphoribosylaminoimidazole carboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59299", "l": "an N-acylglycine + 2 L-ascorbate + O2 <=> an N-acyl-(2S)-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66984", "l": "3-methylbutanoyl-CoA + H2O = CoA + H(+) + isovalerate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204485", "l": "Basigin binds CyPA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66044", "l": "2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + H2O + kynurenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65682", "l": "a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontenoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944229", "l": "Association of procollagen type IX (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21788", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032067", "l": "type IV site-specific deoxyribonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23017", "l": "(2R,3S,4S)-3,4-leucopelargonidin + NADP(+) => (2R,3R)-dihydrokaempferol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008953", "l": "penicillin amidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193665", "l": "MYD88 dissociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1564112", "l": "Collagen type VI degradation by MMP2,9,11 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58543", "l": "2 L-ascorbate + N-dodecanoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-dodecanoyl-(2S)-hydroxyglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114552", "l": "Thrombin-activated PARs activate G12/13 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59635", "l": "D-xylobiose + O2 <=> D-xylobiono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45102", "l": "mitomycin B + S-adenosyl-L-homocysteine => 6-demethylmitomycin B + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2995334", "l": "COX15 transforms heme O to heme A (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46834", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholest-8-en-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30304", "l": "(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52028", "l": "a jasmonyl-L-amino acid + H2O = a jasmonate + an L-alpha-amino acid"}, {"i": "EC:3.5.1.127", "l": "\"Jasmonoyl-L-amino acid hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30730", "l": "dATP + pyruvate <=> dADP + H(+) + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18907", "l": "acetaldehyde + H(+) + phosphate => H2O + phosphonoacetaldehyde"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030884", "l": "exogenous lipid antigen binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450533", "l": "PKCdelta phosphorylates HuR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201637", "l": "Caspase-mediated cleavage of plectin-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102264", "l": "tRNA-dihydrouridine20 synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014454", "l": "RHOG translocates to the ER membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46533", "l": "2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56319", "l": "3-amino-4-hydroxybenzoate + acetyl-CoA <=> 3-acetylamino-4-hydroxybenzoate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051425", "l": "PTB domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47339", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 16beta,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392834", "l": "Activation of EPACs by cAMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60085", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+) => a 4alpha-methyl-3-oxosteroid + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42926", "l": "2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47601", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate => CMP + ganglioside GM4 (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198611", "l": "AKT phosphorylates IKKalpha (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12866", "l": "1-methyladenosine + H2O => 1-methyladenine + D-ribose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210289", "l": "Recruitment of SYK to p-DAP12 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31141", "l": "3-hydroxy-3-methyl-2-oxobutanoate + H(+) + NADPH => (2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.50", "l": "\"Bothrolysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166869", "l": "TRAF6 binds MEKK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57690", "l": "cob(II)inamide--[corrinoid adenosyltransferase] => apo-[corrinoid adenosyltransferase] + cob(II)inamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954208", "l": "ERBB4s80:ESR1 binds PGR gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30633", "l": "beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "ic": "78.819800280251172", "identifiers": [{"i": "GO:0005253", "l": "anion channel activity"}, {"i": "REACT:R-HSA-432034", "l": "Aquaporin-6 passively transports anions into vesicles (Homo sapiens)"}, {"i": "REACT:R-HSA-432036", "l": "Aquaporin-6 passively transports anions out of vesicles (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58979", "l": "H2O + malonaldehyde + O2 <=> 3-oxopropanoate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39812", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16605", "l": "dodecanoyl-CoA + H2O + oxaloacetate = (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+)"}, {"i": "EC:2.3.3.2", "l": "\"Decylcitrate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58366", "l": "a medium-chain fatty aldehyde + H(+) + NADPH => a medium-chain primary fatty alcohol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3858475", "l": "ppDVL recruits RAC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354060", "l": "Translocation of RIAM to plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9612509", "l": "SGK phosphorylates SRF (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12330", "l": "[(1->3)-alpha-D-glucosyl](n-1) + beta-D-glucose 1-phosphate => [(1->3)-alpha-D-glucosyl](n) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047436", "l": "arylmalonate decarboxylase activity"}, {"i": "MetaCyc:4.1.1.76-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65247", "l": "(2S)-hesperetin + UDP-alpha-D-glucose <=> (2S)-hesperetin 7-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051730", "l": "GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49091", "l": "FAD + H(+) + H2O + squalene <=> FADH2 + hydroxysqualene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11918", "l": "15-oxoprostaglandin E2 + H(+) + NADH => 13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031886", "l": "type 1 member 3 taste receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14880", "l": "ATP + L-glutamate <=> ADP + L-glutamyl 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805061", "l": "CK2 binds FACT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111962", "l": "PDE4A,C,D hydrolyse cAMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42465", "l": "biphenyl-2,2',3-triol + O2 => 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43295", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39177", "l": "(2E)-eicosenoyl-CoA + H2O => (3R)-hydroxyeicosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865275", "l": "PDGF-BB clevage by Furin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018807", "l": "RAC3 GDIs block activation of RAC3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0016828", "l": "hydrolase activity, acting on acid sulfur-sulfur bonds"}, {"i": "EC:3.12.-.-", "l": "\"Acting on sulfur-sulfur bonds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29808", "l": "ATP + H2O + L-leucine(out) => ADP + H(+) + L-leucine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161979", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by ALDH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663174", "l": "p-BMAL1:p-CLOCK,NPAS2 binds PER1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981713", "l": "C4b binds to cell surface (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28550", "l": "acetyl-CoA + anthranilate = CoA + N-acetylanthranilate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420883", "l": "Opsins act as GEFs for G alpha-t (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18221", "l": "1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O = a 1-O-alkyl-2-acetyl-sn-glycerol + phosphate"}, {"i": "EC:3.1.3.59", "l": "\"Alkylacetylglycerophosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50835", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 <=> 17-hydroperoxy-(7Z,10Z,13Z,15E,19Z)-docosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12707", "l": "[protein]-L-beta-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine => [protein]-L-beta-isoaspartate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12808", "l": "(S)-canadine + S-adenosyl-L-methionine <=> (S)-N-methylcanadine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n9"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0070325", "l": "lipoprotein particle receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641206", "l": "RSPOs bind LGRs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27978", "l": "GDP-alpha-D-mannose + H2O = alpha-D-mannose 1-phosphate + GMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-481010", "l": "Surface deployment of platelet dense granule membrane components (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036134", "l": "12-hydroxyheptadecatrienoic acid synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809764", "l": "SBF1 binds MTMR2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45898", "l": "an N-acyl-sphingoid 1-phosphoethanolamine + CMP + H(+) => an N-acyl-sphingoid base + CDP-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17616", "l": "NAD(+) + scyllo-inositol <=> H(+) + NADH + scyllo-inosose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30597", "l": "3,4-dihydroxyphenylacetate + FAD + H(+) + H2O => 4-hydroxyphenylacetate + FADH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878054", "l": "HIPK2 phosphorylates RUNX1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174551", "l": "Formation of alternative pathway C5 convertase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450088", "l": "GLUT1 tetramer binds 4xATP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38603", "l": "NADP(+) = 2'-phospho-cyclic ADP-ribose + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40584", "l": "H2O + hexanedioyl-CoA => CoA + H(+) + hexanedioate"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0005149", "l": "interleukin-1 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60399", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O <=> Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663132", "l": "p-BMAL1:p-CLOCK,NPAS2 binds DBP gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2025890", "l": "Calcineurin binds NFATC1,2,3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4331340", "l": "TP53 binds the BBC3 (PUMA) promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-216048", "l": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49623", "l": "D-erythritol 1-phosphate + NADP(+) <=> D-erythrulose 1-phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40208", "l": "(2E)-tetradecenedioyl-CoA + H2O => (3S)-hydroxytetradecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60659", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-sn-glycero-2,3-cyclic phosphate + choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42291", "l": "6-carboxyhexanoyl-[ACP] + H(+) + L-alanine <=> (S)-8-amino-7-oxononanoate + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102884", "l": "alpha-zingiberene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18762", "l": "a 1,2-diacyl-sn-glycerol + H2O => a fatty acid + a monoacylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182986", "l": "CBL-mediated ubiquitination of CIN85 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15214", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA => (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16767", "l": "D-fructose + H(+) + NADPH => D-mannitol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60981", "l": "12-hydroxydodecanoate + NAD(+) => 12-oxododecanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22914", "l": "3-methyl-2-oxobutanoate + L-alanine => L-valine + pyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050140", "l": "nitrate reductase (cytochrome) activity"}, {"i": "RHEA:12909", "l": "2 [Fe(II)cytochrome] + 2 H(+) + nitrate = 2 [Fe(III)cytochrome] + H2O + nitrite"}, {"i": "EC:1.9.6.1", "l": "\"Nitrate reductase (cytochrome)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23730", "l": "A + H2O + prostaglandin H2 => (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102198", "l": "L-idonate 5-dehydrogenase activity (NAD-dependent)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000310", "l": "xanthine phosphoribosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2404135", "l": "RBP4 binds atROL (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354173", "l": "Activation of Rap1 by cytosolic GEFs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45902", "l": "a 4-saturated (2E)-enoyl-CoA => a (3Z)-enoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0055102", "l": "lipase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088439", "l": "FOXM1 binds CENPF promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.10", "l": "\"Neolactotetraosylceramide alpha-2,3-sialyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48562", "l": "D-ribose 5-phosphate + N(6)-dimethylallyladenine => H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34172", "l": "L-aspartate 4-semialdehyde + pyruvate => (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36265", "l": "acetate + H(+) + O-ureido-L-serine => hydroxyurea + O-acetyl-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66142", "l": "CoA + H(+) + N-acetyloctopamine => acetyl-CoA + octopamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031769", "l": "glucagon receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49401", "l": "H2O + validoxylamine A 7'-phosphate => phosphate + validoxylamine A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61954", "l": "CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl-[protein] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42741", "l": "guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42846", "l": "7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide => 6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20180", "l": "pyridoxine + UDP-alpha-D-glucose <=> 5'-O-beta-D-glucosylpyridoxine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50346", "l": "3 CO2 + 4 CoA + 3 H2O + long-chain mycolipanoyl-[mycolipanoate synthase] + 6 NADP(+) => 3 (S)-methylmalonyl-CoA + a long-chain fatty acyl-CoA + 9 H(+) + holo-[mycolipanoate synthase] + 6 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.41", "l": "\"3-hydroxy-D-aspartate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70475", "l": "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40728", "l": "1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid => a 1-acylglycerone 3-phosphate + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47039", "l": "uridine in 5S rRNA <=> pseudouridine in 5S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16328", "l": "1-phospho-alpha-D-glucuronate + H(+) + UTP <=> diphosphate + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114558", "l": "Thrombin-activated PARs activate Gq (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070402", "l": "NADPH binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36429", "l": "diphthine-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine => 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39163", "l": "3-oxohexadecanoyl-CoA + H(+) + NADPH = (3R)-hydroxyhexadecanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22187", "l": "(+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) <=> acenaphthene-1,2-dione + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785087", "l": "FANCM:FAAP24 and APITD1:STRA13 bind ICL-DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58199", "l": "H2O + N(6)-acetyl-L-lysyl-[histone] <=> acetate + L-lysyl-[histone]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016784", "l": "3-mercaptopyruvate sulfurtransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55821", "l": "a 7(1)-hydroxybacteriochlorophyllide d + H2O + S-adenosyl-L-methionine => 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide d + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45035", "l": "4 [Fe(III)cytochrome c] + H2O + hydroxylamine <=> 4 [Fe(II)cytochrome c] + 5 H(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54868", "l": "(2E)-butenoyl-[ACP] + H(+) + NADH = butanoyl-[ACP] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43041", "l": "hexadecanoyl-CoA + hexadecasphinganine => CoA + H(+) + N-hexadecanoylhexadecasphinganine"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0001565", "l": "phorbol ester receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40462", "l": "(2S)-pristanoyl-CoA + O2 <=> (2E)-pristenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40719", "l": "an alkylcob(III)alamin + apo--[alkylcobalamin reductase] + glutathione = an S-substituted glutathione + cob(I)alamin--[alkylcobalamin reductase] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56218", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP => O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35614", "l": "menadiol + 2 O2 <=> 2 H(+) + menadione + 2 superoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5656070", "l": "FGFBPs bind FGFs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11672", "l": "chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate"}, {"i": "EC:2.6.1.85", "l": "\"Aminodeoxychorismate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42876", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = H(+) + N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102854", "l": "1-18:2-2-18:1-phosphatidylcholine desaturase activity"}, {"i": "MetaCyc:RXN-8321"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018764", "l": "N-isopropylammelide isopropylaminohydrolase activity"}, {"i": "MetaCyc:R123-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9006873", "l": "IL21 receptor STAT binding (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430183", "l": "NCK binds PAK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11465", "l": "2 glutathione + L,L-homocystine => glutathione disulfide + 2 L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183126", "l": "Factor B binds to surface-associated C3b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29258", "l": "Ca(2+)(in) + Na(+)(out) <=> Ca(2+)(out) + Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23837", "l": "D-methionine + pyruvate => 4-methylsulfanyl-2-oxobutanoate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14235", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CoA => a 2-acyl-sn-glycerol 3-phosphate + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37804", "l": "a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48954", "l": "14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H(+) + NADH => 14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40054", "l": "chorismate <=> 3-[(1-carboxyvinyl)-oxy]benzoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371353", "l": "Soluble TNF-alpha binds TNFR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36898", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + AH2 + O2 <=> (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626242", "l": "p-GFAP:GFAP dissociates from LAMP2a multimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39448", "l": "(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16999", "l": "3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210300", "l": "Interaction of DAP12 and TREM2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61452", "l": "H(+) + NADPH + O2 + oxytetracycline = 11a-hydroxy-oxytetracycline + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50665", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51432", "l": "(S)-1-aminoethylphosphonate + acetyl-CoA = [(1S)-1-acetamidoethyl]phosphonate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63005", "l": "(11Z,14Z)-eicosadienamide + H2O => (11Z,14Z)-eicosadienoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48080", "l": "abieta-8,11,13-triene + O2 + reduced [NADPH--hemoprotein reductase] = ferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.175", "l": "\"Ferruginol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134946", "l": "DDX41 ubiquitination by TRIM21 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446634", "l": "IRAK4 is activated by autophosphorylation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018724", "l": "4-phenanthrol sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008398", "l": "sterol 14-demethylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32638", "l": "linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (6E)-8-oxolinalool + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218805", "l": "PKC autophosphorylates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39581", "l": "(2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H2O => (3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851018", "l": "BTN2A1 binds DC-SIGN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42272", "l": "3-methylbutanoyl-CoA + H(+) + malonyl-[ACP] = 5-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-264458", "l": "Proteasome mediated degradation of COP1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64432", "l": "H(+)(out) + L-alanyl-L-prolylglycine(out) = H(+)(in) + L-alanyl-L-prolylglycine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15632", "l": "a steroid + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> an 11beta-hydroxysteroid + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0046623", "l": "sphingolipid floppase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33365", "l": "D-mannitol 1-phosphate(in) + L-histidyl-[protein] => D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047443", "l": "4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52739", "l": "3'-phosphoadenylyl sulfate + indolylmethyl-desulfoglucosinolate <=> adenosine 3',5'-bisphosphate + glucobrassicin + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51659", "l": "keto-D-tagaturonate <=> keto-D-fructuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198314", "l": "DAG stimulates protein kinase C-delta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61264", "l": "H2O + L-alanine + O2 = H2O2 + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63268", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + O2 = 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391933", "l": "EP3 receptor can bind PGE2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380234", "l": "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909732", "l": "Phosphorylation of STAT2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34145", "l": "Delta(9)-tetrahydrocannabinolate + H2O2 => cannabinerolate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34231", "l": "5-nitrosalicylate + O2 = 4-nitro-6-oxohepta-2,4-dienedioate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62322", "l": "(+)-isomalbrancheamide B + FADH2 => (+)-premalbrancheamide + chloride + FAD + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46655", "l": "epitestosterone + H(+) + NADPH <=> 5beta-dihydroepitestosterone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5246478", "l": "APOM binds retinoids (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977605", "l": "Factor H displaces Bb (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47154", "l": "2-oxoglutarate + 2 H(+) + NADH => 2,5-dioxopentanoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198270", "l": "PDPK1 phosphorylates AKT at T308 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25857", "l": "(9Z)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.36"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66459", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10858", "l": "a 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphing-4-enine + H(+) + UDP => a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64099", "l": "3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] <=> 2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0019211", "l": "phosphatase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39573", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37815", "l": "(R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 = 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41022", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol <=> 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008426", "l": "protein kinase C inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213208", "l": "Type X collagen associates with collagen type II fibrils (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2473596", "l": "Collagen type I degradation by MMP15 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55967", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607058", "l": "Activated protein C:PROCR binds F2R (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023455", "l": "Autocatalytic phosphorylation of FGFR1c P252X mutant dimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376851", "l": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22315", "l": "5-(methylsulfanyl)-D-ribose + ATP <=> ADP + H(+) + S-methyl-5-thio-alpha-D-ribose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140663", "l": "ATP-dependent FeS chaperone activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48031", "l": "H2O + triacetin <=> acetate + diacetylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62109", "l": "an acyl-CoA + sn-glycero-3-phosphoethanolamine => a monoacyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669023", "l": "TWEAK binds FN14 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13454", "l": "3'-phosphoadenylyl sulfate + quercetin => adenosine 3',5'-bisphosphate + H(+) + quercetin 3-sulfate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031817", "l": "P2Y8 nucleotide receptor binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050592", "l": "4-hydroxyphenylacetaldehyde oxime monooxygenase activity"}, {"i": "MetaCyc:1.14.13.68-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031807", "l": "Protectins translocate from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59974", "l": "CoA + O-decanoyl-L-seryl-[protein] => decanoyl-CoA + L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23387", "l": "D-cellobiose <=> beta-D-glucosyl-(1->4)-D-mannopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46927", "l": "(R)-2-hydroxy-4-methylpentanoyl-CoA <=> 4-methylpent-2-enoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75862", "l": "Fall Back to Closed Pre-initiation Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29579", "l": "Fe(2+)(in) + H(+)(in) = Fe(2+)(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679000", "l": "Ivacaftor binds CFTR G551D (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43418", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23455", "l": "2'-deoxyadenosine + ATP <=> ADP + dAMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803719", "l": "TP53 binds ZNF385A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24840", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine"}, {"i": "EC:4.1.99.17", "l": "\"Phosphomethylpyrimidine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183122", "l": "Factor D cleaves C3b-bound Factor B (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.67"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482892", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9686920", "l": "PELI1 ubiquitinates RIPK3 at K363 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26508", "l": "(9Z)-octadecenoate + NH4(+) => (9Z)-octadecenamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45724", "l": "(E)-4-coumaroyl alcohol + NADP(+) = (E)-4-coumaraldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53601", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372529", "l": "Release of acetylcholine at the synapse (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047580", "l": "4-hydroxyproline epimerase activity"}, {"i": "MetaCyc:4-HYDROXYPROLINE-EPIMERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45770", "l": "L-alaninol + L-glutamate => gamma-glutamyl-L-alaninol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497866", "l": "Peroxynitrite can oxidise BH4 to the BH3 radical (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1461995", "l": "pro-defensin alpha 5 is stored in Paneth cell granules (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19271", "l": "2-furoyl-CoA + AMP + diphosphate => 2-furoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20203", "l": "AMP + D-phenylalanine + diphosphate + H(+) => ATP + H2O + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807106", "l": "PTEN undergoes monoubiquitination (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70427", "l": "PGM:Mg2+ isomerise G1P to G6P (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71849", "l": "LDH tetramer reduces PYR to LACT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044717", "l": "8-hydroxy-dADP phosphatase activity"}, {"i": "REACT:R-HSA-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170120", "l": "Translocation of Cdc25B to the cytoplasm (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64706", "l": "benzophenone + H(+) + NADH => diphenylmethanol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186765", "l": "PLC-gamma binds to the active receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46306", "l": "16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186798", "l": "GAP binds to PDGF-beta receptors only (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51566", "l": "(25S)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981809", "l": "ST6GALNAC3/4 can add a sialic acid to the sialyl T antigen to form the disialyl T antigen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0052870", "l": "tocopherol omega-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45833", "l": "(3R)-3-hydroxydecanoyl-CoA + NAD(+) => 3-oxodecanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50704", "l": "1-propanol + NAD(+) = H(+) + NADH + propanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57168", "l": "(R)-2-hydroxyglutarate + FAD + H(+) = 2-oxoglutarate + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9688459", "l": "RIPK3 binds HSP90:CDC37 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013108", "l": "GDIs block activation of RHOC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641147", "l": "DACT1 binds DVL2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698758", "l": "FLT3 ITD- and NOX4-dependent H2O2 production (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39818", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + octadecanoate <=> 2-hydroxyoctadecanoate + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.12", "l": "\"Nepenthesin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25423", "l": "3-hydroxybenzoyl-CoA + AH2 + 2 ATP + 2 H2O <=> 3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA + A + 2 ADP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1878002", "l": "XYLTs transfer Xyl to core protein (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392831", "l": "Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16302", "l": "H2O + NAD(+) => ADP-D-ribose + H(+) + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061664", "l": "Pup ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675790", "l": "MTORC1 dissociates from ULK complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429497", "l": "SLP-76 stimulates PLC gamma 2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52554", "l": "3-dehydro-4-O-phospho-L-erythronate + ADP + H(+) => 3-dehydro-L-erythronate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54470", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + octanoate => 1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14764", "l": "H(+) + hexadecanoyl-CoA + L-serine <=> 3-oxosphinganine + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43059", "l": "5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH <=> 10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47444", "l": "3-oxo-(7Z-hexadecenoyl)-CoA + CoA = (5Z)-tetradecenoyl-CoA + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11321", "l": "UDP-beta-L-arabinopyranose => UDP-alpha-D-xylose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12202", "l": "CO2 + mugineate + succinate => 2'-deoxymugineate + 2-oxoglutarate + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004337", "l": "geranyltranstransferase activity"}, {"i": "RHEA:19361", "l": "(2E)-geranyl diphosphate + isopentenyl diphosphate = (2E,6E)-farnesyl diphosphate + diphosphate"}, {"i": "EC:2.5.1.10", "l": "\"(2E,6E)-farnesyl diphosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864729", "l": "PITX2 gene expression is stimulated by TFAP2A,TFAP2C homodimers:CITED2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351341", "l": "Exocytosis of Proactivator polypeptide (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21193", "l": "D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O => D-galactosyl-N-acetyl-beta-D-galactosamine + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10599", "l": "ATP + L-tyrosyl-[protein] <=> ADP + H(+) + O-phospho-L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64373", "l": "beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O => alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + N-acetyl-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353435", "l": "Elongation by Pol eta (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209179", "l": "IAP2:BEN:UEV1A E3 ligase complex auto-ubiquitinates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54641", "l": "(+)-copalyl diphosphate => (12E)-labda-8(17),12,14-triene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034892", "l": "endosulfan lactone lactonase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37372", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O => a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20655", "l": "cucurbitacin B + H(+) + NADH => 23,24-dihydrocucurbitacin B + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2900765", "l": "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15238", "l": "2 [Fe(III)-cytochrome c2] + NADPH => 2 [Fe(II)-cytochrome c2] + H(+) + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27698", "l": "GDP-beta-L-galactose + phosphate = beta-L-galactose 1-phosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139905", "l": "Translocation of activated BAD protein to mitochondria (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102300", "l": "linoleate 9R-lipoxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30494", "l": "L-valine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426223", "l": "Cation influx mediated by TRPC3/6/7 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371527", "l": "HSF1 trimer translocates to the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50840", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111930", "l": "Adenylate cyclase produces cAMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73757", "l": "Binding of RRN3 to RNA Polymerase I (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159005", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49131", "l": "AH2 + N-acetyl-demethyl-L-phosphinothricin + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + 2 H(+) + L-methionine + N-acetyl-L-phosphinothricin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32187", "l": "cholest-5-en-3-one = cholest-4-en-3-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51412", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = (8R)-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419843", "l": "CALCA(83-119) binds CALCR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047217", "l": "sucrose-1,6-alpha-glucan 3(6)-alpha-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29403", "l": "6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + AH2 + O2 = 3-demethylubiquinol-8 + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43978", "l": "14-hydroxyhexadecanoate + H2O + NADP(+) => H(+) + hexadecanoate + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161775", "l": "ALOX12 oxidises LTA4 to LXA4/B4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58654", "l": "rifamycin SV para-naphthoquinone carboxamide => rifamycin SV ortho-naphthoquinone carboxamide"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0034483", "l": "heparan sulfate sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665767", "l": "Activated FMNL3 binds G-actin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45064", "l": "H2O + N-hexadecanoylethanolamine = ethanolamine + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22993", "l": "3-oxopropanoate + CoA + NAD(+) => acetyl-CoA + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55087", "l": "(3R)-3-hydroxypentanoyl-CoA + H2O <=> (3R)-3-hydroxypentanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134946", "l": "DDX41 ubiquitination by TRIM21 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18507", "l": "Delta(1)-piperideine-2-carboxylate + H(+) + NADH + NH4(+) => L-lysine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59201", "l": "ATP + docosanoate + H(+) => diphosphate + docosanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028526", "l": "NR1H2 or NR1H3, NRIP1 bind the SCD gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26375", "l": "[thioredoxin]-dithiol + prostamide H2 => [thioredoxin]-disulfide + prostamide F2alpha"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21957", "l": "UDP-alpha-D-glucose + vitexin => H(+) + UDP + vitexin 2''-O-beta-D-glucoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19277", "l": "ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)"}, {"i": "EC:6.1.1.26", "l": "\"Pyrrolysine--tRNA(Pyl) ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-984671", "l": "Chromokinesins form dimers (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050089", "l": "mannose isomerase activity"}, {"i": "MetaCyc:MANNOSE-ISOMERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64031", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8)-citryl-spermidine <=> H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371567", "l": "DBC1 is phosphorylated by ATM/ART (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58731", "l": "adenosine in rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66466", "l": "scalarane-17alpha-19-diol => (2E,6E,10E,14E)-geranylfarnesol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35368", "l": "(2E)-15-methylhexadecenoyl-CoA + H(+) + NADPH => isoheptadecanoyl-coA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43871", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(in) <=> a 1-acyl-sn-glycero-3-phosphoethanolamine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209910", "l": "Iodide is taken up by thyroid epithelial cells (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209738", "l": "VD3 binds GC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66293", "l": "an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose => an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390909", "l": "HRH2 binds hist (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670156", "l": "PtdIns(4,5)P2 binds WASP, N-WASP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228408", "l": "Retrograde transport of internalized tetX HC:LC:gangliosides (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22013", "l": "precorrin-4 + S-adenosyl-L-methionine => precorrin-5 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42374", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine => 16-methoxytabersonine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14725", "l": "2 ATP + 2 cob(II)inamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)inamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63227", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 <=> 2-[12-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl]-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694452", "l": "Protein E forms a homopentamer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102753", "l": "chlorophyllide b:geranyl-geranyl diphosphate geranyl-geranyltransferase activity"}, {"i": "MetaCyc:RXN-7673"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.n2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52843", "l": "4-hydroxy-3-methoxybenzoate + UDP-alpha-D-glucose <=> 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683593", "l": "ATG7:ATG3:LC3 dissociates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45089", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1861789", "l": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791158", "l": "Expression of CXXC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603784", "l": "PEX19:class I PMP binds PEX3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11734", "l": "H(+) + H2O + leachianone G + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + sophoraflavanone B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.6.2.-", "l": "\"Linked to the hydrolysis of a nucleoside triphosphate\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62721", "l": "3 H(+) + 3 NADPH + 3 O2 + probetaenone I => betaenone B + 3 H2O + 3 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57958", "l": "dimethyl sulfone + H2O + NAD(+) => dimethyl sulfoxide + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-500717", "l": "Activation of GRIK3 homomer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44535", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58989", "l": "(E)-4-hydroxynon-2-enal + H2O + O2 => (E)-4-hydroxynon-2-enoate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59470", "l": "an S-substituted L-cysteinylglycine + L-glutamate => an S-substituted glutathione + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-167415", "l": "G-protein alpha subunit is inactivated (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25324", "l": "N-methylethanolamine phosphate + S-adenosyl-L-methionine <=> H(+) + N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41488", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134901", "l": "LRR FLII-interacting protein 1 associates with beta-catenin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805399", "l": "TAF1 phosphorylates TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626681", "l": "Recruitment of transition zone proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042328", "l": "heparan sulfate N-acetylglucosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933292", "l": "LSR trimer binds VLDL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2512800", "l": "SCARB1:ligand is endocytosed (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16592", "l": "A + sucrose <=> 3-dehydro-alpha-D-glucosyl beta-D-fructofuranoside + AH2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018548", "l": "pentaerythritol trinitrate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37373", "l": "a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GDP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74059", "l": "PDE6 hydrolyses cGMP to GMP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58176", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADPH = all-trans-lycopaoctaene + 2 diphosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41169", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+) => a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24553", "l": "5alpha-cholestan-3-one + NADP(+) => cholest-4-en-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26247", "l": "diphosphate + fusicocca-2,10(14)-diene => geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76052", "l": "Binding of TFIIIA To type 1 Promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35265", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388981", "l": "The Kiss receptor GPR54 binds kisspeptin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693198", "l": "RHOD binds effectors at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005132", "l": "type I interferon receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170978", "l": "p-FRS2:CRKL binds C3G (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030629", "l": "U6 snRNA 3'-end binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60847", "l": "a 5'-end diphospho-guanosine in mRNA + GTP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58961", "l": "benzaldehyde + H2O + O2 => benzoate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38522", "l": "1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-octadecanoylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42324", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + reduced coenzyme F420-(gamma-Glu)(n) = 3 H(+) + oxidized coenzyme F420-(gamma-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.5.7.2", "l": "\"Coenzyme F420 oxidoreductase (ferredoxin)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54758", "l": "AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide => deamido-NAD(+) + hydrogencarbonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686578", "l": "Activated ATM phosphorylates ABL1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19250", "l": "glyoxylate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55638", "l": "AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate => ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11487", "l": "2 [Fe(III)cytochrome c](out) + a quinol <=> 2 [Fe(II)cytochrome c](out) + a quinone + 2 H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5656070", "l": "FGFBPs bind FGFs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18375", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42293", "l": "a fatty acyl-[ACP] + phosphate => an acyl phosphate + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062156", "l": "mitochondrial ATP-gated potassium channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43300", "l": "alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP-N-acetyl-alpha-D-galactosamine = H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-glycoloylneuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25793", "l": "ATP + Cu(+)(in) + H2O => ADP + Cu(+)(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.57", "l": "\"Leucyl endopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52632", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP = [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168886", "l": "Hemopexin binds Hemes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46836", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8865605", "l": "BRWD1 binds SMARCA4 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35269", "l": "ethanol(out) => ethanol(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54354", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41792", "l": "holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]"}, {"i": "EC:2.3.1.39", "l": "\"[Acyl-carrier-protein] S-malonyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77077", "l": "Capping complex formation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53071", "l": "4-methoxyestrone + UDP-alpha-D-glucuronate <=> 4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61414", "l": "ADP + H(+) + N-(3-O-phospho-D-erythrulosyl)-cadaverine => ATP + N-(D-erythrulosyl)-cadaverine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16424", "l": "an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376126", "l": "DSCAM binds Netrin-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050411", "l": "agaritine gamma-glutamyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9005995", "l": "MECP2 binds the SIN3A co-repressor complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103043", "l": "5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-354066", "l": "Translocation of PTK2 to Focal complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24765", "l": "UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate => UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31530", "l": "N(omega)-hydroxy-L-arginine <=> (S)-1-pyrroline-5-carboxylate + guanidine + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111962", "l": "PDE4A,C,D hydrolyse cAMP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977228", "l": "Sialyltransferase I can add sialic acid to the T antigen at the alpha 6 position (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33482", "l": "an acyl-CoA + lanosterol <=> CoA + lanosteryl ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15444", "l": "(S)-dihydroorotate + O2 <=> H2O2 + orotate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008740", "l": "L-rhamnose isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174255", "l": "Degradation multiubiquitinated Cyclin A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65984", "l": "hnu + previtamin D3 = lumisterol 3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63459", "l": "(2E,6E,10E)-geranylgeraniol + CTP <=> (2E,6E,10E)-geranylgeranyl phosphate + CDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15176", "l": "H(+) + H2O2 + NADPH <=> 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399978", "l": "Protein kinase C, alpha type phosphorylates MARCKS (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265428", "l": "Interaction of integrin alpha9beta1 with VCAM1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30429", "l": "(+)-germacrene D + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19027", "l": "H2O2 + NH4(+) + oxaloacetate => H2O + L-aspartate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391935", "l": "DP1 receptor can bind PGD2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.1"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015066", "l": "alpha-amylase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211191", "l": "Association of DFF with alpha:beta importin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0099181", "l": "structural constituent of presynapse"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51226", "l": "2 [Fe(II)cytochrome c] + 2 H(+) + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein] => 2 [Fe(III)cytochrome c] + S-sulfanyl-L-cysteinyl-[SoxY protein] + thiosulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69173", "l": "Joining of adjacent Okazaki fragments (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12285", "l": "3-hydroxy-3-methylglutarate + succinyl-CoA => (3S)-hydroxy-3-methylglutaryl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874193", "l": "CREB3L1 translocates from the cytosol to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672948", "l": "MARK3 phosphorylates KSR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1474210", "l": "Collagen type III degradation by MMP14 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45291", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2 <=> 2-glyceryl-prostaglandin G2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938930", "l": "RUNX1 binds ELF2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47518", "l": "isochenodeoxycholate + NAD(+) => 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033997", "l": "inulin fructotransferase (DFA-I-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49917", "l": "(R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in) => (R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11056", "l": "4-aminobenzoate + 2 H(+) + NADPH + O2 = 4-aminophenol + CO2 + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67013", "l": "a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) => a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102489", "l": "GTP phosphohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682598", "l": "ATM phosphorylates HERC2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40271", "l": "O2 + tetradecanedioyl-CoA = (2E)-tetradecenedioyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25607", "l": "2-(3-methylsulfanyl)propylmalate + CoA + H(+) => 2-(5-methylsulfanyl)oxopentanoate + acetyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35992", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23473", "l": "2 alpha,alpha'-trehalose 6-mycolate => alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41883", "l": "(2E)-dodecenoyl-[ACP] + H(+) + NADPH <=> dodecanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32048", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate => adenosine 5'-pentaphosphate + AMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31920", "l": "indolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] => 3-hydroxyindolin-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56059", "l": "genistein + UDP-alpha-D-glucose <=> genistein 7-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938930", "l": "RUNX1 binds ELF2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700156", "l": "Active ALK dimer binds IRS1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10871", "l": "a 1,2-diacyl-sn-glycerol + an acyl-CoA <=> a triacyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004185", "l": "serine-type carboxypeptidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004831", "l": "tyrosine-tRNA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36977", "l": "adenine + alpha-D-ribose 1,5-bisphosphate => AMP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62903", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc + GDP-beta-L-fucose <=> alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-GlcNAc + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63597", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine => a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867613", "l": "PICALM binds R-SNAREs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52053", "l": "9-hexadecanoyloxy-octadecanoate + H2O => 9-hydroxy-octadecanoate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60040", "l": "H2O + N(2)-[(2E)-3-methylhex-2-enoyl]-L-glutaminate = (2E)-3-methylhex-2-enoate + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10802", "l": "5-phospho-alpha-D-ribose 1-diphosphate + xanthine => diphosphate + XMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49272", "l": "alfacalcidol + O2 + reduced [NADPH--hemoprotein reductase] = calcitriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664867", "l": "NBR1 binds MAP1LC3B (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167537", "l": "Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193643", "l": "PRDM4 (SC1) binds to p75NTR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76386", "l": "CYP1A2 S-demethylates 6MMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18537", "l": "H2O + NAD(+) + salicylaldehyde = 2 H(+) + NADH + salicylate"}, {"i": "EC:1.2.1.65", "l": "\"Salicylaldehyde dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51886", "l": "D-proline betaine => L-proline betaine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48440", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol = a fatty acid + H(+) + long chain 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24531", "l": "(R)-lactaldehyde + NAD(+) <=> H(+) + methylglyoxal + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047103", "l": "3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65496", "l": "3beta-hydroxy-5beta-pregnane-20-one + H(+) + NADPH = 3beta,20alpha-dihydroxy-5beta-pregnane + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40664", "l": "L-serine => 2-aminoprop-2-enoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11329", "l": "dimethylallyl diphosphate + isopentenyl diphosphate => diphosphate + neryl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19647", "l": "a D-threo-aldono-1,5-lactone + H(+) + NADH => a D-threo-aldose + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11286", "l": "H(+) + NADH + oxomalonate => hydroxymalonate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33746", "l": "an N-acylsphing-4-enine 1-phosphate + H2O <=> an N-acylsphing-4-enine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047825", "l": "D-lactate-2-sulfatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41460", "l": "1,2-diacyl-glycero-3-phosphocholine + an N-acylsphing-4-enine = a 1,2-diacylglycerol + a sphingomyelin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877620", "l": "ECE2 cleaves EDN1(53-90) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66497", "l": "GDP-alpha-D-rhamnose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102047", "l": "indole-3-acetyl-glycine synthetase activity"}, {"i": "MetaCyc:RXN-10429"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204861", "l": "Interaction of Tie2 and Shc1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74986", "l": "Elongation of pre-rRNA transcript (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373748", "l": "SEMA4D interacts with CD72 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5606996", "l": "Soluble PROCR binds activated protein C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17583", "l": "an L-alpha-amino acid + CO2 + NH4(+) => an N-carbamoyl-L-2-amino acid + 2 H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5682388", "l": "Autophagosome maturation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445084", "l": "Phosphorylation of L1 by SRC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53634", "l": "(3S)-(+)-asterisca-2(9),6-diene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19627", "l": "acetaldehyde + glycine => L-threonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295632", "l": "PPA2A dephosphorylates SPRY2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.214", "l": "\"C(7)-cyclitol 7-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810139", "l": "HOXA2 chromatin is activated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29787", "l": "ATP + glutathione(in) + H2O = ADP + glutathione(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035439", "l": "halimadienyl-diphosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39256", "l": "(13Z)-3-oxodocosenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(13Z)-docosenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416929", "l": "PTGFR binds PGF2a (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004861", "l": "cyclin-dependent protein serine/threonine kinase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15312", "l": "(2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin] <=> biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47138", "l": "AMP + diphosphate + lithocholoyl-CoA => ATP + CoA + lithocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682388", "l": "Autophagosome maturation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592238", "l": "Expression of ALAS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "81.790986234327661", "identifiers": [{"i": "GO:0022835", "l": "transmitter-gated channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56414", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-ditetradecanoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022851", "l": "GABA-gated chloride ion channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191303", "l": "FDPS dimer transfers IPPP to GPP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27734", "l": "4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate"}, {"i": "EC:3.5.1.n3", "l": "\"4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28634", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate <=> 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36849", "l": "AMP + FMN-L-threonyl-[protein] + H(+) => FAD + L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937792", "l": "RUNX3 binds SRC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69299", "l": "CDT1 binds geminin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15666", "l": "aldehydo-D-glucose + L-lysyl-[protein] => H2O + N(6)-(D-fructosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34220", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O + NAD(+) => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163416", "l": "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44330", "l": "glycerol + H(+) + octanoate => 1-octanoylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112395", "l": "Abortive termination of elongation after arrest (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15397", "l": "dichloromethane + H2O = 2 chloride + formaldehyde + 2 H(+)"}, {"i": "EC:4.5.1.3", "l": "\"Dichloromethane dehalogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66448", "l": "(E)-pent-2-en-1-ol + NADP(+) = (E)-2-pentenal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53819", "l": "hydrogen sulfide + O-succinyl-L-serine <=> L-cysteine + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63697", "l": "SN-38 + UDP-alpha-D-glucuronate => H(+) + SN-38 O-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59036", "l": "4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213195", "l": "Formation of anchoring fibrils (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13967", "l": "L-homocysteine + NH4(+) + pyruvate => H2O + L,L-cystathionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714481", "l": "RAC2 binds effectors at the ER membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.38", "l": "\"Glutamin-(asparagin-)ase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59637", "l": "D-xylotriose + O2 => D-xylotriono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21641", "l": "NADP(+) + prephenate => 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390425", "l": "FAR1 reduces PalmCoA to HXOL (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44416", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62898", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc + GDP + H(+) => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008441", "l": "3'(2'),5'-bisphosphate nucleotidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093342", "l": "SDC2 multimerises (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044606", "l": "phosphocholine hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49610", "l": "2-glutathionyl-2-methylbut-3-enoate + 2 H(+) + NADH => 2-glutathionyl-2-methylbut-3-enal + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10932", "l": "ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)"}, {"i": "EC:6.3.4.5", "l": "\"Argininosuccinate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45551", "l": "[R-phycocyanin alpha-subunit]-Cys(84)-phycourobilin <=> (2R,3E)-phycoerythrobilin + apo-[R-phycocyanin alpha-subunit]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043837", "l": "valine dehydrogenase (NAD) activity"}, {"i": "RHEA:30763", "l": "H2O + L-valine + NAD(+) = 3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+)"}, {"i": "EC:1.4.1.23", "l": "\"Valine dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66521", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3772430", "l": "CTNNBIP1 binds beta-catenin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32740", "l": "1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine => a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050054", "l": "lignostilbene alpha beta-dioxygenase activity"}, {"i": "RHEA:21340", "l": "1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 = 2 vanillin"}, {"i": "EC:1.13.11.43", "l": "\"Lignostilbene alpha-beta-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047625", "l": "adenosylmethionine cyclotransferase activity"}, {"i": "KEGG.REACTION:R00180"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12579", "l": "(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-glucose <=> (5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005091", "l": "guanyl-nucleotide exchange factor adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18632", "l": "ATP + NAD(+) <=> ADP + H(+) + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34445", "l": "CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+) => acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874184", "l": "CREB3L1 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18387", "l": "acetoacetate + 2 AMP + 4 H(+) + 4 phosphate => acetone + 2 ATP + 3 H2O + hydrogencarbonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65542", "l": "an N-acyl-sphingoid base + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose => ganglioside GM3 + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015374", "l": "neutral, basic amino acid:sodium:chloride symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.77", "l": "\"Snapalysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54087", "l": "7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine <=> archaeosine(15) in tRNA + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50235", "l": "8 H(+) + heme b + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> biliverdin IXalpha + CO + Fe(2+) + 3 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41789", "l": "acetyl-CoA + holo-[ACP] => acetyl-[ACP] + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25497", "l": "(2E)-geranyl diphosphate => (1S,5S)-beta-pinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10693", "l": "6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 => H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65046", "l": "4-cyanobenzaldehyde + H(+) + NADH => 4-cyanobenzyl alcohol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51114", "l": "20-hydroxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805792", "l": "p-S291-PHF20 translocates to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691004", "l": "XPC binds RAD23 and CETN2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30826", "l": "UDP-N-acetyl-alpha-D-glucosamine <=> H2O + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44380", "l": "a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53395", "l": "2-phenylacetate + O2 + reduced [NADPH--hemoprotein reductase] <=> (2-hydroxyphenyl)acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18552", "l": "[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->4)-alpha-D-glucosyl](n+1) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36547", "l": "octadecanoyl-CoA + sphinganine = CoA + H(+) + N-(octadecanoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390846", "l": "D2D3,4 bind to DA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65014", "l": "AMP + decanoyl-[ACP] + H(+) => decanoyl-AMP + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604294", "l": "Gamma-secretase cleaves NOTCH4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36329", "l": "diphosphate + N(6)-(dimethylallyl)adenosine 5'-diphosphate => ADP + dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63955", "l": "a sphingoid 1-phosphate + H2O <=> a sphingoid base + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.2", "l": "\"Dynein ATPase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38210", "l": "19-oxo-androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> estrone + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507869", "l": "Aquaporins passively transport glycerol into cells (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13845", "l": "dihydroxyfumarate + H(+) = 2-hydroxy-3-oxopropanoate + CO2"}, {"i": "EC:4.1.1.54", "l": "\"Dihydroxyfumarate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68610", "l": "Formation of ORC(2-5) complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042602", "l": "riboflavin reductase (NADPH) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396370", "l": "VTN binds collagens II, III and V (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102743", "l": "eriodictyol,NADPH:oxygen oxidoreductase activity"}, {"i": "MetaCyc:RXN-7653"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340560", "l": "PORCN-inhibitor LGK974 prevents WNT ligand palmitoyltation and secretion (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033841", "l": "6G-fructosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696947", "l": "USP47 deubiquitinates POLB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49442", "l": "(R)-2-hydroxy-4-methylpentanoyl-CoA + 4-methylpentanoate => (R)-2-hydroxy-4-methylpentanoate + 4-methylpentanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36073", "l": "D-glucose + tulipalin A => 6-tuliposide A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.21", "l": "\"Dipeptidase E\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56726", "l": "4-hydroxy-all-trans-beta-carotene + A + H2O => AH2 + all-trans-beta-carotene + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66557", "l": "dopamine + L-glutaminyl-[protein] => 5-dopaminyl-L-glutamyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211983", "l": "CYP2J2 oxidises ARA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44122", "l": "CoA + octadecanyl hexadecanoate => hexadecanoyl-CoA + octadecan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.45"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047167", "l": "1-alkyl-2-acetylglycerol O-acyltransferase activity"}, {"i": "RHEA:21996", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + an acyl-CoA = a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA"}, {"i": "EC:2.3.1.125", "l": "\"1-alkyl-2-acetylglycerol O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17775", "l": "AMP + diphosphate + L-cysteinyl-tRNA(Cys) => ATP + L-cysteine + tRNA(Cys)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58560", "l": "15alpha-stemmadenine intermediate II + NADP(+) = 15alpha-stemmadenine intermediate I + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797993", "l": "TP53 and CREBBP bind BNIP3L gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3149519", "l": "MMACHC decyanates CNCbl (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51200", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-retinylidene-N-retinylethanolamine = H2O + N-retinylidene-N-retinylphosphatidylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58041", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + H2O => (9Z,12Z,15Z)-octadecatrienoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432378", "l": "Nuclear JET binds CRY, facilitating its ubiquitination (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54161", "l": "2-oxoglutarate + [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + O2 => [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65511", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + H2O + O2 <=> H2O2 + NH4(+) + pre-mycofactocin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35295", "l": "adenylyl-molybdopterin + H(+) + tungstate = AMP + H2O + W-molybdopterin cofactor"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20486", "l": "(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-cheilanthifoline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036432", "l": "all-trans undecaprenol kinase activity"}, {"i": "RHEA:23752", "l": "all-trans-undecaprenol + ATP = ADP + all-trans-undecaprenyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13421", "l": "an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate = an N-acylneuraminate 9-phosphate + phosphate"}, {"i": "EC:2.5.1.57", "l": "\"N-acylneuraminate-9-phosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187213", "l": "Synthesis of GAG polyprotein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58302", "l": "25-substituted-cholesteryl beta-D-glucoside + N-octadecanoylsphing-4-enine => 25-substituted-cholesterol + beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120328", "l": "ATP-dependent DNA (cytosine-5-)-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41739", "l": "3'-phosphoadenylyl sulfate + a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) <=> adenosine 3',5'-bisphosphate + beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18113", "l": "a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160931", "l": "Disassembly of tight junctions (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5334794", "l": "FABPs bind LCFAs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42371", "l": "dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620813", "l": "RBL2 gene expression is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164617", "l": "Elongation of Extended Telomeric Chromosome End (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49368", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+) = 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507868", "l": "Aquaporins passively transport water into cells (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12326", "l": "L-asparagine + N-acetyl-D-glucosamine => H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71303", "l": "RPE dimers isomerise RU5P to XY5P (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43192", "l": "cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.225", "l": "\"tRNA:m(4)X modification enzyme\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442739", "l": "PDPK1 phosphorylates RSKs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49631", "l": "acetyl-CoA + 3 malonyl-CoA + 2 S-adenosyl-L-methionine <=> 3,5-dimethylorsellinate + 3 CO2 + 4 CoA + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16687", "l": "CoA + dolichyl hexadecanoate => di-trans,poly-cis-dolichol + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38505", "l": "a 1-acyl-sn-glycerol + a fatty acid + H(+) => 1,3-diacyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37525", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357429", "l": "AXL autophosphorylates on Y772 and Y814 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66371", "l": "6-methyl-3,7-dioxodecanedioyl-CoA + CoA <=> 4-methyl-5-oxo-octanedioyl-CoA + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351936", "l": "Caspase-mediated cleavage of claspin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876210", "l": "InlB promotes MET dimerization (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48548", "l": "[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol"}, {"i": "EC:3.1.1.89", "l": "\"Protein phosphatase methylesterase-1\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879221", "l": "PSTPIP1 binds Pyrin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40775", "l": "2-amino-2-phenylacetonitrile + H(+) + 2 H2O = D-alpha-phenylglycine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785213", "l": "LIPC dimer binds heparin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57059", "l": "D-apiofuranose + NAD(+) <=> D-apionolactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44597", "l": "a fatty acyl-[ACP] + H2O => a fatty acid + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5632668", "l": "SMO translocates to the cilium (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40864", "l": "FAD + H(+) + heptadecanoyl-CoA => FADH2 + trans-2-heptadecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983422", "l": "Disassembly of COPII coated vesicle (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13342", "l": "a menaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + an 8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42338", "l": "[thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin] => [thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202692", "l": "PIP3 binds to RhoA and activates it (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034798", "l": "fosfomycin 2-L-cysteine ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110215", "l": "Cleavage of uracil by UNG glycosylase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047797", "l": "cyclohexanone dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29172", "l": "a ubiquinol + 2 O2 => a ubiquinone + 2 H(+) + 2 superoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022872", "l": "protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265545", "l": "NPC1L1-mediated phytosterol uptake (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27818", "l": "L-idonate + NAD(+) = 2-dehydro-L-idonate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30962", "l": "9,9'-di-cis-zeta-carotene + a quinone <=> 7,9,9'-tri-cis-neurosporene + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653596", "l": "Defective SLC35C1 does not transport UDP-Fuc from cytosol to Golgi lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49483", "l": "2 H2O + L-1-piperideine-6-carboxylate + NADP(+) <=> H(+) + L-2-aminoadipate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31883", "l": "(S)-2,3-epoxysqualene = delta-amyrin"}, {"i": "EC:5.4.99.55", "l": "\"Delta-amyrin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.91", "l": "\"7-methylguanosine nucleotidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110244", "l": "Excision of FapyG by OGG1 glycosylase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371537", "l": "DBC1 binds SIRT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28372", "l": "hydrogencarbonate + phosphoenolpyruvate => oxaloacetate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40851", "l": "FAD + H(+) + pentadecanoyl-CoA = (2E)-pentadecenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.30"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.194"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38902", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) <=> a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675948", "l": "TNFRSF6B binds TNFSF6,14,15 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23490", "l": "hydroquinone + NADP(+) => 1,4-benzoquinone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5660666", "l": "CBP and p300 binds NF-kB complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807565", "l": "GNLY is transferred to the phagosome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17335", "l": "acetate + H(+) + L-lupinate => O-acetyl-L-serine + zeatin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.66", "l": "\"Choriolysin L\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042392", "l": "sphingosine-1-phosphate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57346", "l": "3-hydroxy-4-methyl-D-kynurenine + H(+) + S-adenosyl-L-homocysteine => 3-hydroxy-D-kynurenine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2769000", "l": "NOTCH1 PEST domain mutants bind DLL4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-381091", "l": "IRE1 dimer autophosphorylates (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633295", "l": "TP53 binds the NDRG1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56275", "l": "4 [Fe(III)cytochrome cL] + H2O + methanol <=> 4 [Fe(II)cytochrome cL] + formate + 5 H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "65.48928698272745", "identifiers": [{"i": "GO:0046527", "l": "glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2530591", "l": "CREG (CR1L) causes dissociation of C3 convertases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40405", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19686", "l": "(E)-feruloyl-CoA + tyramine => CoA + H(+) + N-[(E)-feruloyl]tyramine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17373", "l": "all-trans-antheraxanthin = all-trans-capsanthin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701000", "l": "BRCA1:BARD1 heterodimer autoubiquitinates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427337", "l": "MBD2 binds methylcytosine in chromatin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848930", "l": "PTK6 translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080122", "l": "AMP transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700175", "l": "Active ALK phosphorylates SHC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036065", "l": "Defective ARSB does not hydrolyse DS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-744231", "l": "SLC35D2 exchanges UDP-sugars for UMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158399", "l": "kallikrein binds SERPING1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.89"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52617", "l": "3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + ATP => 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-threonyl-[protein] + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102524", "l": "tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity"}, {"i": "RHEA:37899", "l": "2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2 = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate"}, {"i": "EC:1.14.11.42", "l": "\"tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14490", "l": "a nucleoside 2',3'-cyclic phosphate + H2O => a nucleoside 2'-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1013020", "l": "Activation of GIRK/Kir3 Channels (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53309", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22096", "l": "phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)"}, {"i": "EC:2.7.7.8", "l": "\"Polyribonucleotide nucleotidyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42337", "l": "[thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => [thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48336", "l": "a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59954", "l": "2,6-dimethylheptanoate + CoA + H(+) => 2,6-dimethylheptanoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5603467", "l": "Activated protein C is released from PROCR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47712", "l": "trans-3-hydroxy-L-proline = cis-3-hydroxy-D-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67142", "l": "H(+) + H2O + L-citrulline + S-nitroso-L-cysteinyl-[NO transferase protein] => L-cysteinyl-[NO transferase protein] + N(omega)-hydroxy-L-arginine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-571324", "l": "IRAK2 binds to p-IRAK4:MyD88:activated TLR7 or 21 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10868", "l": "a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA"}, {"i": "EC:2.3.1.20", "l": "\"Diacylglycerol O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44070", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62053", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphate + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33265", "l": "(E)-phenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-phenylalanine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22148", "l": "a plastoquinol + 2 H(+)(in) + 2 oxidized [plastocyanin] = a plastoquinone + 4 H(+)(out) + 2 reduced [plastocyanin]"}, {"i": "EC:7.1.1.6", "l": "\"Plastoquinol--plastocyanin reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55440", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + maniladiol + oxidized [NADPH--hemoprotein reductase]"}, {"i": "RHEA:55444", "l": "O2 + oleanolate + reduced [NADPH--hemoprotein reductase] = cochalate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.63", "l": "\"Beta-amyrin 16-beta-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47229", "l": "docosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64684", "l": "L-threonyl-[protein] + UDP-alpha-D-glucose = 3-O-(alpha-D-glucosyl)-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5649856", "l": "Oxidative damage to the AP site (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982807", "l": "JAK2 phosphorylation of GHR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36622", "l": "2-hydroxydocosanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxydocosanoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391913", "l": "FPR2 binds FPR2 ligands (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38406", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O <=> (9Z,12Z)-octadecadienoate + 1,3-di-(9Z,12Z)-octadecadienoylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198440", "l": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19766", "l": "glycerol => 3-hydroxypropanal + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56694", "l": "4-[(E)-2-isocyanoethenyl]phenol + 2 CO2 + H2O + succinate => (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12931", "l": "(2R)-homocitrate + CoA + H(+) => 2-oxoglutarate + acetyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39540", "l": "(2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH => (19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661184", "l": "Defective SLCO1B1 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396009", "l": "STING binds c-di-GMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53559", "l": "(9R,10S)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(9R,10S)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10779", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+) <=> 3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23522", "l": "acetate + propanoyl-CoA => acetyl-CoA + propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52590", "l": "7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH => choloyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43117", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + N-octanoylsphinganine + O2 => 2 [Fe(III)-cytochrome b5] + H2O + N-octanoyl-4-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373073", "l": "Receptors CCR1, 2 and 8 bind CCL16 ligand (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672978", "l": "RAF phosphorylates MAP2K dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29183", "l": "menaquinol-8 + 2 O2 = 2 H(+) + menaquinone-8 + 2 superoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45374", "l": "(9Z)-octadecenoate + sphinganine => H2O + N-(9Z-octadecenoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018827", "l": "1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27813", "l": "dimethylallyl diphosphate + 2 isopentenyl diphosphate <=> (2Z,6Z)-farnesyl diphosphate + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23491", "l": "1,4-benzoquinone + H(+) + NADPH <=> hydroquinone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13853", "l": "4-methylene-L-glutamate + ATP + NH4(+) = 4-methylene-L-glutamine + AMP + diphosphate + H(+)"}, {"i": "EC:6.3.1.7", "l": "\"4-methyleneglutamate--ammonia ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57786", "l": "4-nitrocatechol + H(+) + NAD(+) + nitrite => 1,4-dinitrobenzene + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-179410", "l": "Association of Nek2A with MCC:APC/C (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031682", "l": "G-protein gamma-subunit binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65940", "l": "(R)-glycerate + GDP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64545", "l": "acetyl-CoA + 8 AH2 + ATP + 4 H(+) + holo-[ACP] + L-tyrosine + 7 malonyl-CoA + 2 S-adenosyl-L-methionine => 8 A + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203977", "l": "SAR1 Activation And Membrane Binding (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61640", "l": "H(+) + isophthalyl-CoA = benzoyl-CoA + CO2"}, {"i": "EC:4.1.1.118", "l": "\"Isophthalyl-CoA decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40784", "l": "docosanoyl-CoA + H2O => CoA + docosanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29532", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73945", "l": "FAS-mediated dimerization of procaspase-8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433456", "l": "Recruitment of STATs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444647", "l": "C3a receptor binds anaphylatoxin C3a (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28854", "l": "melibiose(in) + Na(+)(in) <=> melibiose(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786155", "l": "POLN binds ICL-DNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28476", "l": "D-glucarate(out) => D-glucarate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848250", "l": "ACBD6 binds LCFA-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30506", "l": "H2O + N-acetyl-L-glutamate 5-semialdehyde <=> acetate + L-glutamate 5-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46013", "l": "(S)-malate + a quinone => a quinol + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26071", "l": "3-(hydrohydroxyphosphoryl)pyruvate + acetyl-CoA + H2O <=> CoA + H(+) + phosphinomethylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426355", "l": "NTN4 binds laminins with gamma-1, gamma-3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "42.910977646612025", "identifiers": [{"i": "GO:0016491", "l": "oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12846", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O => [L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198621", "l": "AKT phosphorylates caspase-9 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444100", "l": "PROT mediates L-proline uptake (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102577", "l": "3-oxo-palmitate decarboxylase activity"}, {"i": "MetaCyc:RXN-15283"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47729", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP-alpha-D-mannose => (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52183", "l": "(E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] <=> (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55593", "l": "2 (3R)-hydroxydecanoyl-[ACP] + H2O => (3R)-3-[(3R)-3-hydroxydecanoyloxy]decanoate + H(+) + 2 holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864690", "l": "TFAP2A,(TFAP2B) homodimers bind the KIT gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8981931", "l": "RAC1 and CDC42 activate PAK2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14265", "l": "(S)-4-amino-5-oxopentanoate = 5-aminolevulinate"}, {"i": "EC:5.4.3.8", "l": "\"Glutamate-1-semialdehyde 2,1-aminomutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71783", "l": "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53827", "l": "NAD(+) + taurochenodeoxycholate <=> 7-oxotaurolithocholate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51317", "l": "(9Z)-octadecenoate + glycine => H2O + N-(9Z-octadecenoyl)glycine"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0000268", "l": "peroxisome targeting sequence binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10062", "l": "CoA + H(+) + N-acetyl-D-tryptophan => acetyl-CoA + D-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62421", "l": "a (R)-2-hydroxy fatty acid + O2 => a fatty acid + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909738", "l": "SHP1 and SHP2 bind the common beta chain (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63882", "l": "2 [Fe(II)cytochrome c] + cyanate + 2 H(+) + sulfur => 2 [Fe(III)cytochrome c] + H2O + thiocyanate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-156930", "l": "GTP-binding activates eEF2 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62143", "l": "dTMP + GTP <=> dTDP + GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55985", "l": "(R)-mandelonitrile + UDP-alpha-D-glucose => (R)-prunasin + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32200", "l": "androsta-1,4-diene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58947", "l": "6 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 12 H(+) + malonyl-CoA + 6 NADPH <=> 7 CO2 + 8 CoA + demethyldeoxyspectinabilin + 5 H2O + 6 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033928", "l": "mannan 1,4-mannobiosidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034808", "l": "benzo(a)pyrene 4,5-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67007", "l": "a 5'-end triphospho-ribonucleoside in mRNA + H2O <=> a 5'-end diphospho-ribonucleoside in mRNA + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39949", "l": "a fatty acid + a monoacylglycerol + H(+) => 1,3-diacyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32599", "l": "7-hydroxy-4-isopropenyl-7-methyloxepan-2-one = 3-isopropenyl-6-oxoheptanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0044390", "l": "ubiquitin-like protein conjugating enzyme binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10313", "l": "H(+) + NADH + O2 + terephthalate => (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9734687", "l": "ORC6 is phosphorylated on T195 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114256", "l": "CYCS:APAF1 binds procaspase-9 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.65", "l": "\"Sugiol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15840", "l": "L-glutamate + methylamine <=> N-methyl-L-glutamate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34014", "l": "ergosta-5,7,24(28)-trien-3beta-ol + 2 H2O + NADP(+) <=> ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31911", "l": "beta-D-fructose 1,6-bisphosphate + methylglyoxal = 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.4", "l": "\"Gly-Xaa carboxypeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-164834", "l": "Enzyme-bound ATP is released (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166817", "l": "Cleavage of C3 by C3 convertases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627104", "l": "XIAP binds CASP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707516", "l": "FeHM dissociates from MetHb (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004102", "l": "choline O-acetyltransferase activity"}, {"i": "RHEA:18821", "l": "acetyl-CoA + choline = acetylcholine + CoA"}, {"i": "EC:2.3.1.6", "l": "\"Choline O-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2186780", "l": "Degradation of Ub-SMAD7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39519", "l": "3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15591", "l": "4-hydroxyphenylglyoxylate + L-glutamate => 2-oxoglutarate + D-4-hydroxyphenylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34262", "l": "(+)-larreatricin + AH2 + O2 <=> (+)-3'-hydroxylarreatricin + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22538", "l": "H(+) + S-adenosyl-L-homocysteine + tetrahydropalmatine => (S)-tetrahydrocolumbamine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033505", "l": "PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67077", "l": "L-histidyl-[protein] + S-adenosyl-L-methionine => H(+) + N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0010484", "l": "H3 histone acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24071", "l": "cyclohexanone + H(+) + NADPH + O2 <=> H2O + hexano-6-lactone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404144", "l": "Parenchymal atROL translocates to HSCs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202534", "l": "Ubiquitination of NEMO by TRAF6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34254", "l": "1-deoxysphinganine + NADP(+) <=> 1-deoxy-3-dehydrosphinganine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13930", "l": "agmatine + H2O => putrescine + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36058", "l": "a 2-amino-4-hydroxypteridine + H(+) + H2O <=> a 2,4-dihydroxypteridine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210426", "l": "Glutamate synaptic vesicle docking and priming (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27855", "l": "(2E)-geranyl diphosphate + 4-hydroxybenzoate => 3-geranyl-4-hydroxybenzoate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373075", "l": "Metabotropic glutamate receptors bind glutamate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2327733", "l": "FN1 binds Collagen types I-V, VII (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983700", "l": "SYK binds the activated BCR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37281", "l": "ADP + H(+) + L-alanyl-L-histidine(in) + phosphate => ATP + H2O + L-alanyl-L-histidine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65013", "l": "decanoyl-AMP + holo-[ACP] => AMP + decanoyl-[ACP] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141139", "l": "Trimerization of TRAIL:TRAIL receptor complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374686", "l": "L1 interaction with Integrins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45189", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033412", "l": "UAG codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429036", "l": "SLC2A9 transports Fru, Glc, urate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38994", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18475", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP => 1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3791319", "l": "NID1 degradation by MMP19 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17676", "l": "quercetin + S-adenosyl-L-methionine <=> 3',4',5,7-tetrahydroxy-3-methoxyflavone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24508", "l": "NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin E2"}, {"i": "EC:1.1.1.189", "l": "\"Prostaglandin-E(2) 9-reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47273", "l": "monoanhydrobacterioruberin => bisanhydrobacterioruberin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.109"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43603", "l": "3-oxoeicosanoyl-[ACP] + H(+) + NADPH <=> 3R-hydroxyeicosanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47194", "l": "[Co(I) methylated-thiol-specific corrinoid protein] + H(+) + methyl-coenzyme M => [methyl-Co(III) methylated-thiol-specific corrinoid protein] + coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43858", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) => a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3781941", "l": "WNTs are secreted in exosomes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373745", "l": "SDK1 homophillic interaction (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396599", "l": "Recruitment of GRB2:SOS to p-5Y-LAT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44853", "l": "(5Z)-tetradecenoyl-CoA + (R)-carnitine => CoA + O-(5Z)-tetradecenoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69140", "l": "RPA binds to the Flap (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686625", "l": "LAIR1 binds collagen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54046", "l": "7-epi-alpha-eudesmol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15900", "l": "4-acetamidobutanoate + H2O <=> 4-aminobutanoate + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68914", "l": "DNA polymerase alpha:primase binds at the origin (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14397", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) = (4Z)-2-oxohept-4-enedioate + CO2"}, {"i": "EC:4.1.1.68", "l": "\"5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165195", "l": "GTP loading by Rheb (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070733", "l": "protein adenylyltransferase activity"}, {"i": "EC:2.7.7.n1", "l": "\"Protein adenylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985091", "l": "OAS3 produces oligoadenylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033748", "l": "hydrogenase (acceptor) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786110", "l": "JAK1 binds IL4R in IL13-bound IL13R type II (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28496", "l": "a menaquinol + dimethyl sulfoxide => a menaquinone + dimethyl sulfide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25646", "l": "(2R,5R)-isomenthone + NADP(+) => (R)-pulegone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944220", "l": "Association of procollagen type XXIII (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59640", "l": "D-xylotetraose + O2 = D-xylotetraono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29225", "l": "dihydroxyacetone phosphate + menaquinol-8 => menaquinone-8 + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791114", "l": "Expression of FKBP14 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21990", "l": "4'''-demalonylsalvianin + CoA => malonyl-CoA + pelargonidin 3-O-(6-O-[(E)-caffeoyl]-beta-D-glucoside) 5-O-beta-D-glucoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66746", "l": "ADP + H(+) + N-acetyl-L-aspartate(out) + phosphate => ATP + H2O + N-acetyl-L-aspartate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25701", "l": "H(+) + N,N-dihydroxy-L-hexahomomethionine <=> (E)-9-(methylsulfanyl)nonanal oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65264", "l": "3-hydroxypentacecilide A + A = AH2 + chrodrimanin C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030753", "l": "8-hydroxyfuranocoumarin 8-O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41886", "l": "3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP] => dodecanoyl-[ACP] + H(+) + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299480", "l": "Precursor proteins enter TIMM23 PAM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450488", "l": "BRF1 Complex recruits RNA degradation activities (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450348", "l": "Activated human JNKs migrate to nucleoplasm (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047357", "l": "UDP-galactose-UDP-N-acetylglucosamine galactose phosphotransferase activity"}, {"i": "RHEA:22440", "l": "UDP-alpha-D-galactose + UDP-N-acetyl-alpha-D-glucosamine = H(+) + UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine + UMP"}, {"i": "EC:2.7.8.18", "l": "\"UDP-galactose--UDP-N-acetylglucosamine galactose phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30741", "l": "myo-inositol + phosphate => 1D-myo-inositol 3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015183", "l": "L-aspartate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788611", "l": "HYKK phosphorylates 5HLYS (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24563", "l": "acetyl-CoA + L-serine <=> CoA + O-acetyl-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635868", "l": "ub-GLI is degraded by the proteasome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42965", "l": "uridine(54/55) in tRNA => pseudouridine(54/55) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50262", "l": "(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate => 11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25190", "l": "chloroacetate + H2O => chloride + glycolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53369", "l": "5,6-dihydrouridine(17) in tRNA + NADP(+) => H(+) + NADPH + uridine(17) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35249", "l": "ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA(out) + H(+) + phosphate => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65322", "l": "chrodrimanin A + CO2 + succinate => 2-oxoglutarate + chrodrimanin E + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42791", "l": "cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30523", "l": "GTP + L-glutamate + oxidized coenzyme F420-1 = GDP + H(+) + oxidized coenzyme F420-2 + phosphate"}, {"i": "EC:6.3.2.34", "l": "\"Coenzyme F420-1:gamma-L-glutamate ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166538", "l": "The bound receptor dimerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.99.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24027", "l": "(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate <=> (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56505", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46560", "l": "2 [Fe(II)-cytochrome b5] + episterol + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + ergosta-5,7,24(28)-trien-3beta-ol + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58755", "l": "1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55767", "l": "1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O <=> 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443774", "l": "Trans-homodimerization of Neurofascin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983144", "l": "Transport of Antigen peptide in to ER (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54669", "l": "pre-alpha-onocerin => alpha-onocerin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38375", "l": "bacterioruberin = bisanhydrobacterioruberin + 2 H2O"}, {"i": "EC:4.2.1.161", "l": "\"Bisanhydrobacterioruberin hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20540", "l": "H2O + holo-[ACP] <=> apo-[ACP] + D-pantetheine 4'-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983696", "l": "The Immunoglobulin of the BCR binds antigen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n16"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18443", "l": "5,6-dihydroxyindole + CO2 => D-dopachrome + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614614", "l": "Cysteine is degraded to serine and H2S (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.32", "l": "\"Phosphoenolpyruvate carboxykinase (GTP)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004088", "l": "carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28325", "l": "UDP-alpha-D-glucuronate + wogonin <=> UDP + wogonin 7-O-beta-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112395", "l": "Abortive termination of elongation after arrest (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004424", "l": "imidazoleglycerol-phosphate dehydratase activity"}, {"i": "RHEA:11040", "l": "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O"}, {"i": "EC:4.2.1.19", "l": "\"Imidazoleglycerol-phosphate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32511", "l": "(4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O = (3R,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24505", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 => 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51695", "l": "prephenate + S-adenosyl-L-methionine <=> 3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21287", "l": "all-trans-retinol + NAD(+) <=> all-trans-retinal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102317", "l": "4-methylaminobutyrate oxidase (demethylating) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40988", "l": "EDTA + 2 FMNH2 + 2 O2 => ethylenediaminediacetate + 2 FMN + 2 glyoxylate + 3 H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0080161", "l": "auxin transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56652", "l": "12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+) = 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "65.555602785606126", "identifiers": [{"i": "GO:0004518", "l": "nuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451347", "l": "Activation of JNK by DSCAM (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35245", "l": "adenosine thiamine triphosphate + phosphate => ADP + H(+) + thiamine diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106274", "l": "NAD+-protein-arginine ADP-ribosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678927", "l": "UNC93B1 delivers endosomal full-length TLRs to endolysosome (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070497", "l": "6-carboxy-5,6,7,8-tetrahydropterin synthase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0004977", "l": "melanocortin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38297", "l": "2-oxoglutarate + AH2 => (R)-2-hydroxyglutarate + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803761", "l": "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34337", "l": "22R-hydroxycholesterol + H2O + 2 oxidized [adrenodoxin] => cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432143", "l": "PECAM-1 binds PP2A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33081", "l": "adenine + dehypoxanthine futalosine => 6-amino-6-deoxyfutalosine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35834", "l": "2-oxoglutarate + kanamycin B + O2 <=> 2'-dehydrokanamycin A + CO2 + NH4(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8871370", "l": "p-Y281,292-RUFY1 translocates from cytosol to early endosome membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1606602", "l": "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28374", "l": "ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54074", "l": "beta-thujene + diphosphate => (2E)-geranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12586", "l": "16,17-didehydroprogesterone + H2O => 16alpha-hydroxyprogesterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35278", "l": "3-hydroxyoctadecanoyl-CoA + NAD(+) <=> 3-oxooctadecanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19847", "l": "H(+) + isonocardicin A + S-methyl-5'-thioadenosine => nocardicin E + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10374", "l": "benzoyl-CoA + CO2 + NADH => CoA + NAD(+) + phenylglyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036357", "l": "2-phosphoglycerate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693061", "l": "STAMBP binds STAM (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24708", "l": "(6S)-5,6,7,8-tetrahydrofolate + H(+) + UDP-4-deoxy-4-formamido-beta-L-arabinose => (6S)-10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56401", "l": "[(3R)-hydroxybutanoate](n) + H2O => (3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17396", "l": "3-maleylpyruvate <=> 3-fumarylpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24074", "l": "12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197958", "l": "FPGS-2 transforms THF to THFPG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445079", "l": "Phosphorylation of L1 by ERK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44549", "l": "an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an (omega-1)-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13037", "l": "ATP + H(+) + H2O = ITP + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45504", "l": "[C-phycoerythrin alpha-subunit]-Cys(84)-phycoerythrobilin = (2R,3E)-phycoerythrobilin + apo-[C-phycoerythrin alpha-subunit]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5635854", "l": "GLI2,3 are degraded by the proteasome (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66324", "l": "iodide(out) = iodide(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12561", "l": "hydroquinone + UDP-alpha-D-glucose => H(+) + hydroquinone O-beta-D-glucopyranoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23169", "l": "coformycin + NADP(+) => 8-oxocoformycin + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "76.711710297129045", "identifiers": [{"i": "GO:0140110", "l": "transcription regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50066", "l": "ADP + H(+) + phosphate + taurochenodeoxycholate(out) => ATP + H2O + taurochenodeoxycholate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14435", "l": "a tRNA with a 3' CCA end + 3 diphosphate => a tRNA precursor + ATP + 2 CTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60479", "l": "2 ATP + GTP <=> cyclic AMP-AMP-GMP + 3 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373042", "l": "2-oxoglutarate (alpha-ketoglutarate) + CoASH + NAD+ => succinylCoA + CO2 + NADH + H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641134", "l": "SMURF2 binds AXIN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42216", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) = 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050583", "l": "hydrogen dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71164", "l": "homogentisate + O2 => maleylacetoacetate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62839", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34997", "l": "L-rhamnose(out) => L-rhamnose(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12855", "l": "dhurrin + H(+) + UDP => (S)-4-hydroxymandelonitrile + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14548", "l": "H2O + nicotinamide <=> NH4(+) + nicotinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804724", "l": "MDM2 ubiquitinates phosphorylated MDM4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36437", "l": "a 1,2-diacyl-sn-glycero-3-phosphate(out) => a 1,2-diacyl-sn-glycero-3-phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53783", "l": "beta-muricholate + lithocholoyl-CoA <=> beta-muricholoyl-CoA + lithocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9698408", "l": "PTPRJ dephosphorylates active FLT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416929", "l": "PTGFR binds PGF2a (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013143", "l": "RAC1 GEFs activate RAC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36848", "l": "FAD + L-threonyl-[protein] => AMP + FMN-L-threonyl-[protein] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189406", "l": "4 PBGs bind to form HMB (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444202", "l": "Receptor FFAR1 binds free fatty acids (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084505", "l": "Laminins bind HSPG2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49364", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + H(+) = 17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044508", "l": "glucagon-like peptide 1 receptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050079", "l": "acetylenecarboxylate hydratase activity, producing 3-oxopropanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50744", "l": "2 glyphosate + O2 = 2 aminomethylphosphonate + 2 glyoxylate + 2 H(+)"}, {"i": "EC:1.5.3.23", "l": "\"Glyphosate oxidoreductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8934819", "l": "Cytoplasmic proteases cleave Profilaggrin producing Filaggrin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25680", "l": "AMP + diphosphate + O-phospho-L-seryl-tRNA(Cys) => ATP + O-phospho-L-serine + tRNA(Cys)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050082", "l": "maltose phosphorylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46552", "l": "2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (9Z)-octadec-9-en-12-ynoyl-containing glycerolipid + 2 H2O"}, {"i": "EC:1.14.19.39", "l": "\"Acyl-lipid Delta(12)-acetylenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045482", "l": "trichodiene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854408", "l": "APOBR dimer binds VLDLs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54445", "l": "a (2R,3S,4S)-leucoanthocyanidin + NADP(+) => a (2R,3R)-dihydroflavonol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871376", "l": "p-Y281,292-RUFY1 binds PI3P (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66173", "l": "H(+)(out) + L-cystine(out) => H(+)(in) + L-cystine(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033425", "l": "CAU codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805103", "l": "AURKA phosphorylates TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46438", "l": "(25R)-3beta,4beta-dihydroxycholest-5-en-26-oate + H2O + 2 oxidized [adrenodoxin] => (25R)-3beta,4beta-dihydroxycholest-5-en-26-al + H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375151", "l": "Interaction of NCAM1 with collagens (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917693", "l": "ESCRT Disassembly (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57226", "l": "N(2)-(1-hydroxy-2-oxoethyl)-GTP => glyoxal + GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432010", "l": "Aquaporin-1 passively transports water into cell (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61075", "l": "(-)-(R)-19-hydroxytabersonine + acetyl-CoA <=> (-)-(R)-19-O-acetyltabersonine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38894", "l": "H2O + N-hexadecanoylsphing-4-enine <=> hexadecanoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63903", "l": "2 3-(4-hydroxyphenyl)pyruvate + H(+) <=> (2S)-2-(4-hydoxybenzyl)-3-(4-hydroxyphenyl)-2-furonol carboxylate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70427", "l": "PGM:Mg2+ isomerise G1P to G6P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.40"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11080", "l": "dTMP + H2O = phosphate + thymidine"}, {"i": "EC:3.1.3.35", "l": "\"Thymidylate 5'-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987039", "l": "JAK1 binds IL20RA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49096", "l": "H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine = 3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine"}, {"i": "EC:1.21.98.3", "l": "\"Anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804266", "l": "CHEK2 phosphorylates TTC5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51056", "l": "A + androst-4-ene-3,17-dione = AH2 + androsta-1,4-diene-3,17-dione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23617", "l": "1,2-dihydro-alpha-santonin + NADP(+) => alpha-santonin + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010012", "l": "steroid 22-alpha hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029471", "l": "Hydrolysis of PC to PA by PLD (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60132", "l": "a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 = a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28833", "l": "D-gluconate(out) + H(+)(out) => D-gluconate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47659", "l": "acetyl-CoA + L-methionine sulfone <=> CoA + H(+) + N-acetyl-L-methionine sulfone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682712", "l": "nsp15 binds RB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60001", "l": "hydroxymethylphosphonate + O2 => formate + 2 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008770", "l": "[acyl-carrier-protein] phosphodiesterase activity"}, {"i": "RHEA:20537", "l": "H2O + holo-[ACP] = apo-[ACP] + D-pantetheine 4'-phosphate + H(+)"}, {"i": "EC:3.1.4.14", "l": "\"[Acyl-carrier-protein] phosphodiesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48383", "l": "alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose <=> a neolactoside IV(3)-alpha-Gal,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209840", "l": "Two DITs combine to form thyroxine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20749", "l": "2-oxoglutarate + O2 + penicillin N => CO2 + deacetoxycephalosporin C + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38888", "l": "H2O + N-hexanoyl-sphinganine => hexanoate + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103004", "l": "9,10-epoxystearate hydroxylase activity"}, {"i": "MetaCyc:RXN-9805"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57571", "l": "7-deoxyloganetic alcohol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-deoxyloganetic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29159", "l": "3 a menaquinol(in) + 2 H(+)(out) + nitrite(out) = 3 a menaquinone(in) + 2 H2O(out) + NH4(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29354", "l": "Zn(2+)(in) <=> Zn(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48426", "l": "(6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dUMP => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847880", "l": "CYTH proteins bind ARF1:GTP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047234", "l": "raffinose-raffinose alpha-galactotransferase activity"}, {"i": "RHEA:14125", "l": "2 raffinose = 1(F)-alpha-D-galactosylraffinose + sucrose"}, {"i": "EC:2.4.1.166", "l": "\"Raffinose--raffinose alpha-galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045549", "l": "9-cis-epoxycarotenoid dioxygenase activity"}, {"i": "RHEA:23328", "l": "a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal"}, {"i": "EC:1.13.11.51", "l": "\"9-cis-epoxycarotenoid dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39198", "l": "3-oxotetracosanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxytetracosanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34241", "l": "3-aminopentanedioate => L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2219536", "l": "AKT1 E17K mutant binds PIP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19225", "l": "glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin]"}, {"i": "EC:1.97.1.4", "l": "\"[Formate-C-acetyltransferase]-activating enzyme\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50891", "l": "an N-acylsphingoid base 1-phosphate + H2O <=> an N-acyl-sphingoid base + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33573", "l": "AH2 + formaldehyde => A + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694334", "l": "mRNA1 is translated to pp1a (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0140360", "l": "cyclic-GMP-AMP transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28801", "l": "glycine + L-proline => H2O + L-prolinylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45941", "l": "12-methyloctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(13-methyl-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36312", "l": "3,4-dihydroxybenzaldehyde + H2O + NAD(+) => 3,4-dihydroxybenzoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65589", "l": "(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58649", "l": "rifamycin SV hemiaminal => H(+) + rifamycin SV ortho-naphthoquinone carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76373", "l": "N-hydroxylation of 4-aminobiphenyl (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161791", "l": "15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052667", "l": "phosphomethylethanolamine N-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43484", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18404", "l": "(E)-4-hydroxyphenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-4-hydroxymandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64073", "l": "acetyl-CoA + 8 H(+) + holo-[ACP] + 8 malonyl-CoA => 3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 8 CO2 + 9 CoA + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27716", "l": "guanosine + phosphate => GMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018774", "l": "RHOBTB1 binds GTP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59128", "l": "(S)-2,3-diaminopropanoate + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + ATP = 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + AMP + diphosphate"}, {"i": "EC:6.3.2.55", "l": "\"2-((L-alanin-3-ylcarbamoyl)methyl)-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950766", "l": "IL27RA dimerizes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15143", "l": "4-hydroxybenzaldehyde + 4 H(+) + 4 reduced [azurin] => 4-methylphenol + H2O + 4 oxidized [azurin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810724", "l": "PI3 binds the bacterial surface (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983158", "l": "Trimming of peptides in ER (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24276", "l": "acetate + diphosphate = acetyl phosphate + phosphate"}, {"i": "EC:2.7.2.12", "l": "\"Acetate kinase (diphosphate)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627106", "l": "SMAC (DIABLO) forms dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27326", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56554", "l": "ADP + H(+) + O-phospho-L-threonyl-[rhodopsin] => ATP + L-threonyl-[rhodopsin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430308", "l": "PARVB interacts with Alpha-actinin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24586", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 2 H(+) + NADH => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34160", "l": "acetyl-CoA + UDP-N-acetylbacillosamine => CoA + H(+) + UDP-N,N'-diacetylbacillosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694409", "l": "Nucleotide exchange on RAB1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097371", "l": "MDM2/MDM4 family protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28141", "l": "H2O + streptothricin F <=> streptothricin F acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28841", "l": "H(+)(in) + Zn(2+)(out) => H(+)(out) + Zn(2+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35890", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15759", "l": "H(+) + L-aspartate 4-semialdehyde + NADH => L-homoserine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029451", "l": "Activation of RAC1 by VAV (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879221", "l": "PSTPIP1 binds Pyrin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66055", "l": "indole-3-pyruvate + L-kynurenine <=> H2O + kynurenate + L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202437", "l": "Phosphorylation of CARMA1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685953", "l": "SIRT6 deacetylates RBBP8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2032781", "l": "WWTR1 (TAZ) binds TEAD (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42761", "l": "D-glyceraldehyde 3-phosphate + H2O + NAD(+) => (2R)-3-phosphoglycerate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659922", "l": "Defective SI does not hydrolyze Mal (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76426", "l": "N-atom dealkylation of caffeine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64046", "l": "CoA + H(+) + N-(13Z-docosenoyl)-sphing-4-enine => (13Z)-docosenoyl-CoA + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380782", "l": "STAT binds to the active receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70479", "l": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106006", "l": "cytoskeletal protein-membrane anchor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098744", "l": "1-phosphatidylinositol 4-kinase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18654", "l": "barbiturate + H2O => 3-oxo-3-ureidopropanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34535", "l": "H(+) + hexadecanoyl-CoA + L-alanine = 1-deoxy-3-dehydrosphinganine + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048249", "l": "high-affinity phosphate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48220", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tricosanoyl-CoA = (2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237160", "l": "MTA is cleaved and phosphorylated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31120", "l": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA => (2E)-2-methylbut-2-enoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28154", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}, {"i": "EC:2.4.99.14", "l": "\"(Kdo)(2)-lipid IV(A) (2-8) 3-deoxy-D-manno-octulosonic acid transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52691", "l": "3-phenyllactate + NAD(+) <=> 3-phenylpyruvate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65920", "l": "L-kynurenine + pyruvate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46211", "l": "ATP + CoA + eicosanoate <=> AMP + diphosphate + eicosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52200", "l": "1-aci-nitro-2-(phenyl)ethane + glutathione = (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211206", "l": "Translocation of DFF to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1176059", "l": "Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0042288", "l": "MHC class I protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-400204", "l": "PPARA binds RXRA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40117", "l": "CoA + H(+) + hexanoate => H2O + hexanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790907", "l": "Box C/D snoRNP methylates ribonucleotides in pre-rRNA yielding 2'-O-methylribonucleotides (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16934", "l": "1-aminocyclopropane-1-carboxylate + H2O => 2-oxobutanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10717", "l": "D-glucose 6-phosphate => 1D-myo-inositol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52309", "l": "2-hydroxyglutarate + NADP(+) => 2-oxoglutarate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29319", "l": "H2O + sn-glycero-3-phosphoethanolamine = ethanolamine + H(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65882", "l": "5alpha-androstan-1,3,17-trione + AH2 => 1-hydroxy-5alpha-androstan-3,17-dione + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449115", "l": "IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28985", "l": "nitrite(out) => nitrite(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614933", "l": "ACEIs bind ACE (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25994", "l": "(+)-epi-isozizaene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51820", "l": "ATP(in) + CoA(in) + decanoate(out) + H(+)(out) = AMP(in) + decanoyl-CoA(in) + diphosphate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11836", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-beta-lactosamine = CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46812", "l": "4,4-dimethyl-8,14-cholestadien-3beta-ol + H(+) + NADPH = 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34627", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046175", "l": "Further sulfation on galactose residues produces KSPG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433711", "l": "Cis-homodimerization of nectins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35924", "l": "neamine + UDP-alpha-D-glucose => 3''-deamino-3''-hydroxykanamycin B + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32038", "l": "(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O <=> (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44364", "l": "2-epi-5-epi-valiolone + ATP = 2-epi-5-epi-valiolone 7-phosphate + ADP + H(+)"}, {"i": "EC:2.7.1.188", "l": "\"2-epi-5-epi-valiolone 7-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805126", "l": "AURKB phosphorylates TP53 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1964496", "l": "STING binds TRIM32 or TRIM56  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26049", "l": "glyceollin II + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0016898", "l": "oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor"}, {"i": "EC:1.1.2.-", "l": "\"With a cytochrome as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40036", "l": "ATP + L-glutamate + N-acetyl-L-aspartate => ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102971", "l": "phosphinothricin N-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69685", "l": "CHEK2 phosphorylates TP53 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63966", "l": "(2E,12Z)-hexadecadienal + phosphoethanolamine => sphinga-4E,14Z-dienine-1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28274", "l": "(S)-S-adenosyl-L-methionine = (R)-S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43760", "l": "acetyl-CoA + N-terminal L-seryl-[ribosomal protein bL12] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[ribosomal protein bL12]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103069", "l": "17-hydroxyprogesterone 21-hydroxylase activity"}, {"i": "RHEA:50308", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "MetaCyc:RXN66-356"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40182", "l": "decanoyl-CoA + O2 <=> (2E)-decenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16183", "l": "3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38163", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050141", "l": "nitroethane oxidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0017110", "l": "nucleoside-diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19079", "l": "3-deoxyglucosone + L-lysyl-[protein] + phosphate => H2O + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372843", "l": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250884", "l": "botF HC transports botF LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11243", "l": "ATP + thiamine diphosphate <=> ADP + thiamine triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167084", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295613", "l": "SPRY2 binds GRB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3240957", "l": "Formation of PRC2-EZH2 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140806", "l": "SERPINC1 binds SERPINC1 activators (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11095", "l": "NAD(+) + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25265", "l": "2-phenylethylamine + H2O + O2 = 2-phenylacetaldehyde + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54905", "l": "(2E,9Z)-hexadecadienoyl-[ACP] + H(+) + NADH => (9Z)-hexadecenoyl-[ACP] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9649733", "l": "mature p21 RAS binds GDP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033436", "l": "AUG codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13416", "l": "ADP + thymidine <=> AMP + dTMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26341", "l": "L-selenocysteine + S-methyl-L-methionine = H(+) + L-methionine + Se-methyl-L-selenocysteine"}, {"i": "EC:2.1.1.280", "l": "\"Selenocysteine Se-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10612", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-xylose = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}, {"i": "EC:2.4.2.38", "l": "\"Glycoprotein 2-beta-D-xylosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2129362", "l": "Fibrillin microfibril assembly (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237160", "l": "MTA is cleaved and phosphorylated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25647", "l": "(R)-pulegone + H(+) + NADPH => (2R,5R)-isomenthone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102808", "l": "pelargonidin 3-O-glucoside 2''-O-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-8177"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52852", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin] = 6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin]"}, {"i": "EC:1.14.14.46", "l": "\"Pimeloyl-[acyl-carrier protein] synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54042", "l": "(3E,7E)-dolathalia-3,7,11-triene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16501", "l": "H2O + sn-glycero-3-phospho-1D-myo-inositol = H(+) + myo-inositol + sn-glycerol 3-phosphate"}, {"i": "EC:3.1.4.44", "l": "\"Glycerophosphoinositol glycerophosphodiesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111883", "l": "Hydrolysis of phosphatidylcholine (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28038", "l": "[thioredoxin]-disulfide + dCDP + H2O = [thioredoxin]-dithiol + CDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661039", "l": "Defective SLC9A6 does not exchange Na+ for H+ across the early endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.245", "l": "\"Alpha,alpha-trehalose synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44077", "l": "ATP + CoA + pentadecanoate => AMP + diphosphate + pentadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61621", "l": "[(1->2)-beta-D-mannosyl](n) + GDP-alpha-D-mannose => [(1->2)-beta-D-mannosyl](n+1) + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34760", "l": "ATP + glycerol 2-phosphate(out) + H2O => ADP + glycerol 2-phosphate(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40325", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48667", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 12,20-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54303", "l": "n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate <=> n adenosine 3',5'-bisphosphate + chondroitin 4',6'-disulfate + n H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38213", "l": "1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA => hexadecane-1,2-diol + 2 hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9679775", "l": "COMT binds COMT Inhibitors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43135", "l": "N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-dimethylguanosine(10) in tRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56792", "l": "2 cob(II)alamin--[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] = 2 [corrinoid adenosyltransferase]-cob(I)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047083", "l": "5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59911", "l": "H2O + hexanal + NADP(+) <=> 2 H(+) + hexanoate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50046", "l": "adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+) => an acyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51844", "l": "(9Z)-hexadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016438", "l": "tRNA-queuosine beta-mannosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624800", "l": "CDK1 phosphorylates LBR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12403", "l": "beta-nicotinamide D-ribonucleotide + H2O <=> NH4(+) + nicotinate beta-D-ribonucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2529020", "l": "CK2 phosphorylates condensin I subunits (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25258", "l": "N-acetyl-D-glucosamine 6-phosphate => N-acetyl-D-mannosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16533", "l": "L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + UDP"}, {"i": "EC:2.4.1.94", "l": "\"Protein N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55547", "l": "L-lysyl-[citrate synthase] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33700", "l": "2 [Fe(II)-cytochrome b5] + C20 sphinganine + 2 H(+) + O2 => (4R)-hydroxyeicosasphinganine + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102615", "l": "ent-cassadiene-C2-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12293", "l": "ATP + L-serine + tRNA(Ser) => AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051670", "l": "inulinase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "73.740524343052556", "identifiers": [{"i": "GO:1901618", "l": "organic hydroxy compound transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50192", "l": "L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP"}, {"i": "EC:2.4.2.26", "l": "\"Protein xylosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24600", "l": "H2O + O2 + sulfite = H2O2 + sulfate"}, {"i": "EC:1.8.3.1", "l": "\"Sulfite oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014467", "l": "RHOG binds effectors at the ER membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51046", "l": "CO2 + NH4(+) + protodeoxyviolaceinate => indole-3-pyruvate imine dimer"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63919", "l": "5-fluorouridine + ATP <=> 5-fluorouridine 5'-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63234", "l": "NAD(+) + octanoyl-CoA => (2E)-octenoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944262", "l": "Association of procollagen type X (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678128", "l": "Spike glycoprotein of SARS coronavirus binds ACE2 on host cell (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45779", "l": "(indol-3-yl)acetonitrile + 2 H2O <=> (indol-3-yl)acetate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381644", "l": "ER calcium channels open in response to activated PKA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58841", "l": "cholesterol sulfate + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0001614", "l": "purinergic nucleotide receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404142", "l": "atROL binds RBP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49594", "l": "(3S)-3-hydroxybutanoyl-CoA => 2-hydroxyisobutanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389756", "l": "AKT interacts and phosphorylates Cot (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419003", "l": "Interaction of Nectins with Afadin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2059926", "l": "NPHP4 protein binds LATS proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3274540", "l": "Defective G6PC does not hydrolyze glucose 6-phosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399712", "l": "Activation of Ca permeable AMPA receptors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49419", "l": "ADP + alpha-D-ribose 1-phosphate <=> alpha-D-ribose 1,5-bisphosphate + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15708", "l": "2 a ubiquinone + H2O + phenylacetyl-CoA <=> 2 a ubiquinol + phenylglyoxylyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.302", "l": "\"2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57914", "l": "H(+) + L-glutaminyl-tRNA(Gln) + phosphate => 5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17718", "l": "1D-myo-inositol 1,4,5-trisphosphate + ATP => 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9611852", "l": "ADRB3 bind ADR,NAd (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784861", "l": "HSPG binds LPL dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8963851", "l": "VD3 dissociates from GC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62620", "l": "[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O"}, {"i": "EC:1.11.1.24", "l": "\"Thioredoxin-dependent peroxiredoxin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10649", "l": "2-hydroxycyclohexan-1-one + H(+) + NADPH + O2 => 6-hydroxyhexan-6-olide + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21987", "l": "3'-phosphoadenylyl sulfate + choline <=> adenosine 3',5'-bisphosphate + choline sulfate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54650", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => ent-8alpha-hydroxylabd-13-en-15-yl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769383", "l": "CBY1 binds beta-catenin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854052", "l": "Formation of the SCF-FBXL7 complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54188", "l": "H2O + N-acetyl-L-phenylalanine = acetate + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23112", "l": "6-methylsalicylate + H(+) = 3-methylphenol + CO2"}, {"i": "EC:4.1.1.52", "l": "\"6-methylsalicylate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62973", "l": "acetyl-CoA + 2 H(+) + 3 malonyl-CoA => 3 CO2 + 4 CoA + orsellinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867047", "l": "PTPN3 dephosphorylates EPS15 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41152", "l": "1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-hydroperoxy-10E-octadecenoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51110", "l": "10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139842", "l": "Binding of Syk tyrosine kinase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48138", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate => ganglioside GM3 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37769", "l": "1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35648", "l": "ATP + GTP => 3',3'-cGAMP + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53980", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41553", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O => diphosphate + ophiobolin F"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681169", "l": "CRBN binds IMiDs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855190", "l": "I(1,4,5)P3 transports from the cytosol to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50945", "l": "3-phenylpropanoate + NAD(+) => (E)-cinnamate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68610", "l": "Formation of ORC(2-5) complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198211", "l": "Active TRKA binds IRS1/2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28420", "l": "(R)-carnitinyl-CoA + 4-(trimethylamino)butanoate => (R)-carnitine + gamma-butyrobetainyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198669", "l": "p38MAPK phosphorylates MSK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28789", "l": "4-(phosphooxy)-L-threonine + ADP + H(+) => 4-hydroxy-L-threonine + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61632", "l": "5-aminopentanal + H2O + NAD(+) = 5-aminopentanoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39914", "l": "(2S,3S)-3-methylphenylalanine + 2-oxoglutarate <=> (3S)-2-oxo-3-phenylbutanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202541", "l": "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102091", "l": "phosphatidylinositol-5-phosphate 5-phosphatase activity"}, {"i": "MetaCyc:RXN-10962"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005463", "l": "UDP-N-acetylgalactosamine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654571", "l": "Activated FGFR1 binds FRS3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40401", "l": "H2O2 + NADP(+) => 1,2-dihydro-beta-NADP + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46896", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) = a 1,2-diacyl-sn-glycerol + lipid A hexaacyl 1-(2-aminoethyl diphosphate)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63789", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17594", "l": "3-phenylpyruvate + L-glutamine => 2-oxoglutaramate + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866851", "l": "CFTR transits to the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18390", "l": "alpha-D-xylose 1-phosphate + H(+) + UTP => diphosphate + UDP-alpha-D-xylose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-169895", "l": "Crk's SH3 domain engages C3G (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41317", "l": "1-O-methyl-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61053", "l": "(-)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] => (-)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60459", "l": "ATP + UTP <=> 3',3'-cUAMP + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854222", "l": "TBC1D3 associates with RAB5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448632", "l": "IL34 dimerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31826", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> cubebol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193705", "l": "IKKbeta phosphorylates IkB causing NF-kB to dissociate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41242", "l": "N-acyl (9Z,12Z)-octadecadienoate octadecasphin-4E-enine + O2 <=> N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32965", "l": "2-oxoglutarate + NH4(+) => 2-oxoglutaramate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507870", "l": "Aquaporins passively transport water out of cells (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-453338", "l": "PGYM b dimer:AMP complex <=> PGYM dimer, b form + 2 AMP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39982", "l": "(+-)-pavine + S-adenosyl-L-methionine <=> H(+) + N-methylpavine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18979", "l": "a quinol + dihydroxyacetone phosphate => a quinone + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20813", "l": "(3S)-citryl-CoA => acetyl-CoA + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57273", "l": "a 2'-deoxyguanosine in DNA + methylglyoxal => an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47618", "l": "ethionamide S-oxide + H2O + NADP(+) => ethionamide + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65564", "l": "(9Z)-octadecenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800044", "l": "TP53 stimulates IGFBP3 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "80.155824608458104", "identifiers": [{"i": "GO:0004386", "l": "helicase activity"}, {"i": "REACT:R-HSA-5686410", "l": "BLM mediates dissolution of double Holliday junction (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38845", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951727", "l": "cAMP binds PKA tetramer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41149", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954513", "l": "NAA translocates from mitochondrial matrix to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801666", "l": "PLK2 phosphorylates CENPJ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67025", "l": "a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine => a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019782", "l": "ISG15 activating enzyme activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445705", "l": "Release Of ADP From Myosin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000074", "l": "TCII binds Cbl in the circulation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21786", "l": "2 H(+) + L-threonate + oxalate => H2O + L-ascorbate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191299", "l": "Squalene is oxidized to its epoxide (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031694", "l": "alpha-2A adrenergic receptor binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005068", "l": "transmembrane receptor protein tyrosine kinase adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662615", "l": "MT1X binds zinc (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051433", "l": "BH2 domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707659", "l": "Hemes:LY96 activates TLR4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32345", "l": "(+)-thujan-3-one + H(+) + NADH => (+)-thujan-3-ol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629369", "l": "NEIL3 recognizes and binds to thymine glycol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0043110", "l": "rDNA spacer replication fork barrier binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029460", "l": "PAK1 phosphorylates LIMK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003994", "l": "aconitate hydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695845", "l": "FLT3 mutant dimers:GRB2 bind SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37745", "l": "phosphate + prenyl-FMNH2 => dimethylallyl phosphate + FMNH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247960", "l": "Activation of p38 MAPK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507869", "l": "Aquaporins passively transport glycerol into cells (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21565", "l": "acetyl-CoA + an acyl-CoA => a 3-oxoacyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210881", "l": "Dimerization of Tie2/Ang1 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784765", "l": "p-Y705-STAT3 dimerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008569", "l": "minus-end-directed microtubule motor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3965450", "l": "DAAM1 recruits PFN1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10250", "l": "diphosphate + dUMP + H(+) => dUTP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32859", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31423", "l": "(2Z,6E)-farnesyl diphosphate = (-)-alpha-cedrene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36210", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an acyl-CoA <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432909", "l": "Interaction of Plectin with Integrin beta 4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687097", "l": "p-S857 NCOA3 binds ETV4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10114", "l": "H2O + L,L-cystathionine => L-homocysteine + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32395", "l": "(1S,2S,4S)-dihydrocarveol + NAD(+) = (1S,4S)-dihydrocarvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50939", "l": "(3S)-3-aminobutanoyl-CoA + 2-oxoglutarate <=> acetoacetyl-CoA + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24468", "l": "H(+) + N,N-dimethylaniline + NADPH + O2 = H2O + N,N-dimethylaniline N-oxide + NADP(+)"}, {"i": "EC:1.14.13.8", "l": "\"Flavin-containing monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59893", "l": "L-2-amino-4-chloropent-4-enoate => chloride + H(+) + L-propargylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57750", "l": "C32-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+) => 2 (S)-methylmalonyl-CoA + 10 H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 3 malonyl-CoA + 5 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11949", "l": "4-hydroxybenzoyl-CoA + H2O => 4-hydroxybenzoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34527", "l": "L-phenylalanine = (S)-3-amino-3-phenylpropanoate"}, {"i": "EC:5.4.3.11", "l": "\"Phenylalanine aminomutase (D-beta-phenylalanine forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33320", "l": "a 1-acyl-sn-glycero-3-phosphate + octadecanoyl-CoA => a 1-acyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60616", "l": "N-dodecanoyl-heptadecasphing-4-enine-1-phosphoethanolamine = ethanolamine + N-dodecanoyl-heptadecasphing-4-enine-1,3-cyclic phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811472", "l": "IER3 recruits MAPKs to PP2A-B56-beta,gamma (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21335", "l": "acetyl-CoA + D-glucosamine <=> CoA + H(+) + N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693012", "l": "TNFSF15 binds TNFRSF25 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606807", "l": "Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54114", "l": "diphosphate + selina-4(15),7(11)-diene => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944457", "l": "MAF1 translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37047", "l": "H(+)(out) + L-histidine(out) = H(+)(in) + L-histidine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62471", "l": "3,4-dihydroxybenzoate + ATP + H(+) <=> 3,4-dihydroxybenzoyl-5'-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24610", "l": "2,5-dioxopentanoate + CO2 + H2O => 5-dehydro-4-deoxy-D-glucarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34224", "l": "6-hydroxypseudooxynicotine + A + H2O => 2,6-dihydroxypseudooxynicotine + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24909", "l": "L-tyrosine <=> (E)-4-coumarate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22140", "l": "a nucleoside 5'-phosphate + H2O = a nucleoside + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17818", "l": "(3R)-hydroxytetradecanoyl-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => H(+) + holo-[ACP] + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34432", "l": "(+)-secoisolariciresinol + NADP(+) => (-)-lariciresinol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72103", "l": "Formation of pre-mRNPs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0016677", "l": "oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor"}, {"i": "EC:1.9.6.-", "l": "\"With a nitrogenous group as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62054", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+) => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12696", "l": "3,4-dihydroxypyridine + O-acetyl-L-serine <=> 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008777", "l": "acetylornithine deacetylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43512", "l": "2-(dihydroxymethyl)-5-formylfuran + O2 = 2-carboxy-5-formylfuran + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70486", "l": "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016152", "l": "mercury (II) reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70596", "l": "GOT2 dimer deaminates L-Asp (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63901", "l": "2 3-(4-hydroxyphenyl)pyruvate + H(+) => (2S)-2-(4-hydoxybenzyl)-3-(4-hydroxyphenyl)-2-furonol carboxylate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53534", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O => (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45628", "l": "holo-[CmaD peptidyl-carrier protein] + L-alloisoleucyl-[CmaA peptidyl-carrier protein] = holo-[CmaA peptidyl-carrier protein] + L-alloisoleucyl-[CmaD peptidyl-carrier protein]"}, {"i": "EC:2.3.2.28", "l": "\"L-allo-isoleucyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66744", "l": "ATP + H2O + N-acetyl-L-aspartate(in) = ADP + H(+) + N-acetyl-L-aspartate(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64587", "l": "2-hydroxyethane-1-sulfonate(out) + Na(+)(out) <=> 2-hydroxyethane-1-sulfonate(in) + Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097641", "l": "alpha-ketoglutarate-dependent xanthine dioxygenase activity"}, {"i": "RHEA:43120", "l": "2-oxoglutarate + O2 + xanthine = CO2 + succinate + urate"}, {"i": "EC:1.14.11.48", "l": "\"Xanthine dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51190", "l": "peroxynitrite => nitric oxide + superoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51806", "l": "diphosphate + H(+) + lupulone => deoxyhumulone + dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48000", "l": "1,6-dihydro-beta-NADP + H(+) + O2 = H2O2 + NADP(+)"}, {"i": "EC:1.6.3.5", "l": "\"Renalase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49527", "l": "2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2 <=> a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18550", "l": "[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->4)-alpha-D-glucosyl](n+1) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18185", "l": "adenosine + O2 = 5'-dehydroadenosine + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26163", "l": "(S)-2,3-epoxysqualene <=> thalianol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022399", "l": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40103", "l": "H2O + propanoyl-CoA = CoA + H(+) + propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22820", "l": "3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP"}, {"i": "EC:2.4.2.62", "l": "\"Xylosyl alpha-1,3-xylosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62649", "l": "(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 => (5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6805981", "l": "HMGB1 release from cells (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33975", "l": "DIMBOA beta-D-glucoside + H2O = D-glucose + DIMBOA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46922", "l": "CO2 + styrene => (E)-cinnamate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48503", "l": "H2O + octanoylglycerol <=> glycerol + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1606288", "l": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140292", "l": "ADP-ribosylserine hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.179", "l": "\"Gellan tetrasaccharide unsaturated glucuronosyl hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42759", "l": "cytidine(1407) in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(1407) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52049", "l": "9-(9Z-octadecenoyloxy)-octadecanoate + H2O => (9Z)-octadecenoate + 9-hydroxy-octadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047774", "l": "cis-2-enoyl-CoA reductase (NADPH) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19179", "l": "(3S)-3,6-diaminohexanoate => L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11117", "l": "acetyl-CoA + an alkane-alpha,omega-diamine => an N-acetylalkane-alpha,omega-diamine + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19342", "l": "2 H(+) + O2 + octane + 2 reduced [rubredoxin] => H2O + octan-1-ol + 2 oxidized [rubredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32433", "l": "(4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+) => (1R,4S)-menthone + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56075", "l": "a 2-acylphloroglucinol + UDP-alpha-D-glucose <=> a 2-acylphloroglucinol 1-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099582", "l": "neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0004559", "l": "alpha-mannosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12102", "l": "H2O + microthecin => 1,5-anhydro-D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938231", "l": "RUNX1:CBFB binds CREBBP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0016933", "l": "extracellularly glycine-gated ion channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23374", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine => ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35018", "l": "riboflavin(in) <=> riboflavin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36975", "l": "AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102007", "l": "acyl-L-homoserine-lactone lactonohydrolase activity"}, {"i": "MetaCyc:3.1.1.81-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683488", "l": "ACE2 is glycosylated to glycosylated-ACE2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167098", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43666", "l": "2-carboxytetracosanoyl-CoA + ADP + H(+) + phosphate => ATP + hydrogencarbonate + tetracosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14660", "l": "aldehydo-D-ribose 5-phosphate <=> D-ribulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15294", "l": "arsenite + S-adenosyl-L-methionine => H(+) + methylarsonate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20753", "l": "A + 2 cob(II)alamin + 2 H(+) + 2 H2O => AH2 + 2 aquacob(III)alamin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.25", "l": "\"Beta-mannosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49256", "l": "2-amino-2-deoxy-D-gluconate(out) + N(pros)-phospho-L-histidyl-[protein] = 2-amino-2-deoxy-D-gluconate 6-phosphate(in) + L-histidyl-[protein]"}, {"i": "EC:2.7.1.203", "l": "\"Protein-N(pi)-phosphohistidine--D-glucosaminate phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52426", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP => L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34637", "l": "H2O + NADP(+) + pentalenolactone D => 1-deoxy-11-oxopentalenate + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35806", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O <=> 7,8-dihydroneopterin 2'-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47563", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) <=> CMP + ganglioside GM1b (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48702", "l": "a fatty acid + H(+) + long chain acyl-3-O-beta-D-galactosyl-sn-glycerol => H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60918", "l": "an N(3)-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in mRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38745", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-octadecenoyl)-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047368", "l": "UDP-N-acetylgalactosamine-4-sulfate sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106324", "l": "(S)-limonene 1,2-monooxygenase NADH activity"}, {"i": "RHEA:26089", "l": "(4S)-limonene + H(+) + NADH + O2 = H2O + limonene 1,2-epoxide + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785165", "l": "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20016", "l": "carbamoyl phosphate + L-aspartate <=> H(+) + N-carbamoyl-L-aspartate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21165", "l": "a carboxylic ester + H2O => a carboxylate + an alcohol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62688", "l": "4 norrubrofusarin + O2 = 2 H2O + 2 ustilaginoidin A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102761", "l": "eriodictyol 3'-O-methyltransferase activity"}, {"i": "RHEA:60948", "l": "(S)-eriodictyol + S-adenosyl-L-methionine = (S)-homoeriodictyol + H(+) + S-adenosyl-L-homocysteine"}, {"i": "MetaCyc:RXN-7753"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362549", "l": "Hh-Np traffics to the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798372", "l": "ATM phosphorylates DYRK2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684273", "l": "3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17351", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate => (2E)-geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21378", "l": "(S)-4-hydroxymandelate + CO2 => 3-(4-hydroxyphenyl)pyruvate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392513", "l": "Rap1 signal termination by Rap1GAPs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48986", "l": "2,4-dichlorophenol + CO2 + glyoxylate + succinate => (2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50526", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-isoleucyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990756", "l": "ubiquitin ligase-substrate adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83656", "l": "TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37476", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55525", "l": "H(+) + H2O + L-dopa + O2 => 3,4-dihydroxyphenylacetaldehyde + CO2 + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24960", "l": "apo-[aequorin] + 3 Ca(2+) + coelenterazine + O2 = [excited state blue fluorescent protein] + CO2"}, {"i": "EC:1.13.12.24", "l": "\"Calcium-regulated photoprotein\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27794", "l": "(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + 4 diphosphate"}, {"i": "EC:2.5.1.30", "l": "\"Heptaprenyl diphosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0016749", "l": "N-succinyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110219", "l": "Cleavage of thymine by TDG glycosylase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432516", "l": "CLK and CYC bind to form a heterodimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48882", "l": "a quinol + CO2 => a quinone + CO + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58013", "l": "cyclic tetraadenylate => 2 5'-hydroxy-diadenylate 2',3'-cylic phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696482", "l": "CTF1 binds LIFR:JAKs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33146", "l": "galactitol(in) <=> galactitol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48822", "l": "13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-984733", "l": "Kinesin-3 is a dimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35533", "l": "albonoursin + 2 H2O2 => cyclo(L-phenylalanyl-L-leucyl) + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432067", "l": "Aquaporin-4 passively transports water out of cell (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65906", "l": "4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine => 3-hydroxy-L-kynurenine + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12152", "l": "(3R,4S,5S,6R)-pentachlorocyclohexene = (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419426", "l": "Cannabinoid receptors can bind cannabinoids (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60823", "l": "H2O + NADPH <=> adenosine 3',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53156", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(5,6-epoxy-8Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199910", "l": "MSK1 activates ATF1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390425", "l": "FAR1 reduces PalmCoA to HXOL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18195", "l": "(S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate => H2O + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36102", "l": "benzoate + S-adenosyl-L-methionine <=> methyl benzoate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022141", "l": "Prolysyl oxidase activation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28128", "l": "alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1606288", "l": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-453200", "l": "SYK autophosphorylates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47476", "l": "(3E)-tetradecenoyl-CoA = (2E)-tetradecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389463", "l": "Proteinase-activated receptors can bind thrombin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31232", "l": "4-acetamidobutanal + H2O + NAD(+) => 4-acetamidobutanoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23342", "l": "D-arabinose + pyruvate => 3-deoxy-alpha-D-manno-oct-2-ulosonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40438", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> H(+) + hexadecanoate + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45176", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.12"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174097", "l": "Association of Emi1 with Cdh1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38814", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51559", "l": "(S)-glaucine + S-adenosyl-L-methionine <=> (S)-N-methylglaucine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40062", "l": "decanoyl-CoA + H2O <=> CoA + decanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36625", "l": "(3S)-2-oxo-3-phenylbutanoate + H(+) + S-adenosyl-L-homocysteine => 3-phenylpyruvate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10776", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57929", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine => ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193519", "l": "DHCA is translocated from the mitochondrial matrix to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28793", "l": "H(+) + NADH + thymine => 5,6-dihydrothymine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176318", "l": "Loading of claspin onto DNA during replication origin firing (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176175", "l": "Stalling of DNA replication fork and RPA binding (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24814", "l": "2-oxoglutarate + L-valine => 3-methyl-2-oxobutanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56353", "l": "4-hydroxybenzoate + bromide + 2 H(+) + NADPH + O2 => 3-bromo-4-hydroxybenzoate + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196017", "l": "Dynamin is recruited to the gap junction plaque (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848414", "l": "Activated PTK6 binds CDKN1B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44919", "l": "(2E,4E)-decadienoyl-CoA + H(+) + NADPH <=> (3E)-decenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.30"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854052", "l": "Formation of the SCF-FBXL7 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158313", "l": "factor XII -> factor XIIa (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27352", "l": "arsenate + mycothiol <=> arseno-mycothiol + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050438", "l": "2-ethylmalate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37740", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine => 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoserine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803836", "l": "FGFR2b-specific alternative splicing produces FGFR2b transcript (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989751", "l": "Expression of FABP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-984671", "l": "Chromokinesins form dimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46113", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549428", "l": "Expression of FACTOR VII (F7) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-918227", "l": "Recruitment of TRAF3 to MAVS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15650", "l": "carbamate + 2 H(+) => CO2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23126", "l": "CO2 + D-ribulose 1,5-bisphosphate + H2O => 2 (2R)-3-phosphoglycerate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11670", "l": "[(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate => [(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112392", "l": "Resumption of elongation after recovery from pausing (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31370", "l": "2 H(+) + 3 nitrite <=> H2O + nitrate + 2 nitric oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27832", "l": "beta-phellandrene + diphosphate => neryl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161293", "l": "Tropoelastin forms aggregate globules (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13632", "l": "(1S,5R)-carveol + NADP(+) <=> (R)-carvone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005547", "l": "phosphatidylinositol-3,4,5-trisphosphate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37677", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28231", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => (+)-costunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102699", "l": "2-methylpropionitrile hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45462", "l": "a fatty acid + H(+) + N,1-diacyl-sn-glycero-3-phosphoethanolamine => H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868236", "l": "BAR domain proteins recruit dynamin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866856", "l": "RNF5 and RNF185 ubiquitinate CFTR F508del (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018459", "l": "carveol dehydrogenase activity"}, {"i": "RHEA:13629", "l": "(1S,5R)-carveol + NADP(+) = (R)-carvone + H(+) + NADPH"}, {"i": "EC:1.1.1.243", "l": "\"Carveol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51795", "l": "H(+) + NADH + O2 + salicylate <=> 2,3-dihydroxybenzoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788867", "l": "FN3K phosphorylates ketosamines (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376122", "l": "DSCAM/DSCAML1 homodimerization (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194678", "l": "CYP51A1 demethylates LNSOL (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10626", "l": "2 ADP + carbamoyl phosphate + 3 H(+) + phosphate => 2 ATP + CO2 + H2O + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730882", "l": "Phosphorylation of PKC-theta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56727", "l": "AH2 + all-trans-beta-carotene + O2 <=> 4-hydroxy-all-trans-beta-carotene + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299481", "l": "TIMM9:TIMM10 binds hydrophobic proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451447", "l": "Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45611", "l": "H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20038", "l": "D-sorbitol 6-phosphate + NADP(+) => aldehydo-D-glucose 6-phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37846", "l": "1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58860", "l": "4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800035", "l": "IGFBP3 binds TMEM219 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015553", "l": "xanthosine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877620", "l": "ECE2 cleaves EDN1(53-90) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047270", "l": "lipopolysaccharide glucosyltransferase II activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635841", "l": "GLI proteins are phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45232", "l": "a (2E,4Z)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(2E)-enoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11397", "l": "5-methyldeoxycytidine 5'-phosphate + ATP => 5-methyldeoxycytidine diphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047761", "l": "butyrate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674140", "l": "PAQR3 binds inactive RAFs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42842", "l": "2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 3 H2O + 2 NADP(+) => acetyl-CoA + 6 H(+) + 5 malonyl-CoA + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63136", "l": "adenosylcob(III)alamin + apo--[alkylcobalamin reductase] + glutathione = cob(I)alamin--[alkylcobalamin reductase] + H(+) + S-adenosylglutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28870", "l": "H(+)(in) + lactose(in) <=> H(+)(out) + lactose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25482", "l": "acetoacetyl-CoA + succinate => acetoacetate + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985591", "l": "SLIT2-bound ROBO1 binds MYO9B (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66443", "l": "butan-2-one + NADP(+) <=> but-3-en-2-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396009", "l": "STING binds c-di-GMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5082391", "l": "Trimerization of HSF1 in the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27512", "l": "dehydro coenzyme F420-0 + GMP + H(+) => 7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54910", "l": "(4E)-hexenoyl-CoA + NADP(+) => (2E,4E)-hexadienoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18097", "l": "pteridine-2,4,6,7-tetrol = H(+) + xanthine-8-carboxylate"}, {"i": "EC:5.5.1.3", "l": "\"Tetrahydroxypteridine cycloisomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12257", "l": "L-arogenate + NAD(+) => CO2 + L-tyrosine + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43347", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+) <=> [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19806", "l": "a purine D-ribonucleoside + phosphate => a purine nucleobase + alpha-D-ribose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39043", "l": "22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase] = docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30694", "l": "H2O2 + methanol <=> formaldehyde + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55699", "l": "a mannosylinositol-1-phospho-N-acyl-sphingoid base + H2O <=> an N-acyl-sphingoid base + H(+) + mannosylinositol-1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66306", "l": "a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-alpha-mannosylinositol-1-phosphoceramide => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-mannosylinositol-1-phosphoceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210700", "l": "KEN dimer represses transcription (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10728", "l": "GDP-6-deoxy-alpha-D-talose + NAD(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804425", "l": "TP53 binds POU4F2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15369", "l": "2,3-dihydroxybenzoate + O2 = 2-carboxy-cis,cis-muconate + 2 H(+)"}, {"i": "EC:1.13.11.28", "l": "\"2,3-dihydroxybenzoate 2,3-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8979071", "l": "KDM6B binds iron (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698029", "l": "p-STAT5 dissociates from mutant FLT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936963", "l": "IRAK2 induces TRAF6 oligomerization (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23577", "l": "(R)-N-methylcoclaurine + (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] => berbamunine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39020", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948757", "l": "AKT phosphorylates MKRN1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210300", "l": "Interaction of DAP12 and TREM2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20685", "l": "galactitol + NAD(+) = H(+) + keto-D-tagatose + NADH"}, {"i": "EC:1.1.1.16", "l": "\"Galactitol 2-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59917", "l": "(2E)-octenal + H2O + NADP(+) => (2E)-octenoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54095", "l": "3,4-dihydroxyphenylacetate + H(+) + NADPH + O2 <=> 2,4,5-trihydroxyphenylacetate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56857", "l": "A + an aldehyde + H2O => a carboxylate + AH2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047690", "l": "aspartyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16214", "l": "3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38777", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3204318", "l": "cob(II)alamin binds to MTRR:MTR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18267", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + H(+) + NADH => 6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691004", "l": "XPC binds RAD23 and CETN2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097351", "l": "toxin sequestering activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31518", "l": "4'-apo-beta-carotenal + H2O + NAD(+) <=> 2 H(+) + NADH + neurosporaxanthin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64224", "l": "AH2 + O2 + uridine(34) in tRNA = 5-hydroxyuridine(34) in tRNA + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389083", "l": "Autophosphorylation of PDGF alpha receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000074", "l": "TCII binds Cbl in the circulation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53566", "l": "18-hydroxy-9,10-epoxy-(12Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9,10-epoxy-(12Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196417", "l": "Reduction of desmosterol to cholesterol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372819", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65052", "l": "4-(trifluoromethyl)benzyl alcohol + NAD(+) = 4-(trifluoromethyl)benzaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18875", "l": "chloride + H(+) + NH4(+) + pyruvate => 3-chloro-D-alanine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65312", "l": "an ultra-long-chain mono-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxo-ultra-long-chain mono-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]"}, {"i": "EC:2.3.1.293", "l": "\"Meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15289", "l": "[(1->4)-beta-D-xylan](n) + UDP-alpha-D-xylose = [(1->4)-beta-D-xylan](n+1) + H(+) + UDP"}, {"i": "EC:2.4.2.24", "l": "\"1,4-beta-D-xylan synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052747", "l": "sinapyl alcohol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61330", "l": "3beta-hydroxyparthenolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + parthenolide + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21572", "l": "3-hydroxy-2-methyl-1H-quinolin-4-one + O2 = CO + H(+) + N-acetylanthranilate"}, {"i": "EC:1.13.11.48", "l": "\"3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036308", "l": "16S rRNA (guanine(1516)-N(2))-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371590", "l": "HSP70 binds to HSP40:nascent protein (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418553", "l": "cAMP degradation by Phosphodiesterases (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34805", "l": "bisdemethoxycurcumin + 2 CO2 + 3 CoA => 2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466764", "l": "NRPE condenses with atRAL to form A2PE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76466", "l": "CYP4A11 12-hydroxylates DDCX (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805285", "l": "PLK3 phosphorylates TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39758", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047522", "l": "15-oxoprostaglandin 13-oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296301", "l": "CCRL2 binds CCL19 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483087", "l": "PI is exchanged with PC by PITPNB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39327", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA = (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0032356", "l": "oxidized DNA binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102495", "l": "GA5 3beta-hydroxylase activity"}, {"i": "MetaCyc:RXN-14318"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050437", "l": "(-)-endo-fenchol synthase activity"}, {"i": "KEGG.REACTION:R02004"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49629", "l": "acetyl-CoA + 3 malonyl-CoA + 2 S-adenosyl-L-methionine => 3,5-dimethylorsellinate + 3 CO2 + 4 CoA + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29669", "l": "H2O(out) => H2O(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46912", "l": "H2O + juvenile hormone III = H(+) + juvenile hormone III carboxylate + methanol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047396", "l": "glycosylphosphatidylinositol diacylglycerol-lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5082356", "l": "HSF1-mediated gene expression (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57565", "l": "(+)-cis-trans-nepetalactol + O2 + reduced [NADPH--hemoprotein reductase] => 7-deoxyloganetic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0001000", "l": "bacterial-type RNA polymerase core enzyme binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14102", "l": "[eIF5A protein]-deoxyhypusine + AH2 + O2 => [eIF5A protein]-hypusine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39142", "l": "(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O <=> (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33912", "l": "an N-alkylglycine + H2O + O2 => an alkylamine + glyoxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46600", "l": "[HPr protein]-L-serine + ATP = [HPr protein]-O-phospho-L-serine + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61120", "l": "kaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 2 H2O + myricetin + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32943", "l": "a 1,2-diacyl-sn-glycerol + CDP-ethanolamine = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18420", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> CMP + ganglioside GM3 (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55055", "l": "H2O + pentanoyl-CoA <=> CoA + H(+) + pentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20290", "l": "acetyl-CoA + H2O => acetate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031782", "l": "type 4 melanocortin receptor binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050548", "l": "trans-feruloyl-CoA hydratase activity"}, {"i": "RHEA:14517", "l": "(E)-feruloyl-CoA + H2O = 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA"}, {"i": "EC:4.2.1.101", "l": "\"Trans-feruloyl-CoA hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15378", "l": "(S)-4,5-dihydroxypentane-2,3-dione + ATP => (2S)-2-hydroxy-3,4-dioxopentyl phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65528", "l": "hexan-1-ol + octanoyl-CoA = CoA + hexyl octanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044101", "l": "(R)-citramalyl-CoA lyase activity"}, {"i": "RHEA:38275", "l": "(3R)-citramalyl-CoA = acetyl-CoA + pyruvate"}, {"i": "MetaCyc:RXN-8967"}, {"i": "EC:4.1.3.46", "l": "\"(R)-citramalyl-CoA lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43999", "l": "2-oxoglutarate + a 3-methyl fatty acyl-CoA + O2 <=> a 2-hydroxy-3-methyl fatty acyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708466", "l": "BACH1 translocates from the nucleoplasm to the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034938", "l": "pyrrole-2-carboxylate monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38897", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32483", "l": "H(+) + H2O + pheophorbide a = CO2 + methanol + pyropheophorbide a"}, {"i": "EC:3.1.1.82", "l": "\"Pheophorbidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003873", "l": "6-phosphofructo-2-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26036", "l": "2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3,8'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202307", "l": "Change of PKC theta conformation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170120", "l": "Translocation of Cdc25B to the cytoplasm (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694436", "l": "MIA2 and MIA3 dissociate from procollagen VII vesicle (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57037", "l": "[(1->6)-alpha-D-glucosyl](n) + sucrose => (1->3)-alpha-D-glucosyl-[(1->6)-alpha-D-glucosyl]n + D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686524", "l": "PP6-PPP6R3 dephosphorylates TERF2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57145", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.6", "l": "\"DNA ligase (ATP or NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63419", "l": "2,6-dichlorohydroquinone + FADH2 + O2 <=> 2-chloro-6-hydroxy-1,4-benzoquinone + chloride + FAD + 2 H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54917", "l": "9-cis-retinol + NADP(+) => 9-cis-retinal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35509", "l": "glycyrrhetaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 30-hydroxy-11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19419", "l": "[phosphate](n+1) + dolichyl phosphate => [phosphate](n) + dolichyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.161"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432164", "l": "Ca2+ influx into the post-synaptic cell (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928657", "l": "MMP2,9 cleave EPHB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874849", "l": "CREBRF binds CREB3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943811", "l": "MECOM (EVI1) binds the PTEN gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30120", "l": "dodecanoyl-[ACP] + H2O => dodecanoate + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63031", "l": "(15Z)-tetracosenamide + H2O <=> (15Z)-tetracosenoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168412", "l": "MDP elicits a NOD2 response (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33808", "l": "(E)-ferulate + H(+) => 2-methoxy-4-vinylphenol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20880", "l": "10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + H(+) + NADH"}, {"i": "EC:1.1.1.66", "l": "\"Omega-hydroxydecanoate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047279", "l": "sn-glycerol-3-phosphate 1-galactosyltransferase activity"}, {"i": "RHEA:20341", "l": "sn-glycerol 3-phosphate + UDP-alpha-D-galactose = 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP"}, {"i": "EC:2.4.1.96", "l": "\"sn-glycerol-3-phosphate 1-galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48612", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]"}, {"i": "EC:2.8.1.11", "l": "\"Molybdopterin synthase sulfurtransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004949", "l": "cannabinoid receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38611", "l": "NAD(+) = cyclic ADP-ribose + H(+) + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604732", "l": "Autocatalytic activation of proMMP13 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975594", "l": "PLB1 hydrolyses RPALM to atROL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2464803", "l": "RDH8 reduces atRAL to atROL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10615", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-xylose <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46295", "l": "a 5'-end triphospho-(purine-ribonucleoside) in mRNA + GDP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3780958", "l": "SOD1:Zn2+ apoenzyme binds CCS:Cu1+ (mitochondrial) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14006", "l": "H2O + L,L-cystathionine => 2-oxobutanoate + L-cysteine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952226", "l": "RUNX3 binds the BCL2L11 (BIM) gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202216", "l": "Phosphorylation of SLP-76 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31311", "l": "(2R)-3-phosphoglycerate + ADP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73757", "l": "Binding of RRN3 to RNA Polymerase I (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445071", "l": "Reinsertion of L1 into the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20877", "l": "(R)-2-benzylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362386", "l": "Glycosylation of Hh (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46483", "l": "4alpha-formyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65162", "l": "CoA + hexan-2-yl benzoate => benzoyl-CoA + hexan-2-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32195", "l": "abieta-7,13-dien-18,18-diol = abieta-7,13-dien-18-al + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24373", "l": "H2O + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] => H(+) + N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047669", "l": "amylosucrase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "64.97931804346041", "identifiers": [{"i": "GO:0016779", "l": "nucleotidyltransferase activity"}, {"i": "REACT:R-HSA-6782434", "l": "THG1L transfers GMP to 5' end of tRNA(His) (Homo sapiens)"}, {"i": "EC:2.7.7.-", "l": "\"Nucleotidyltransferases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55080", "l": "ADP-alpha-D-glucose + D-fructose = ADP + H(+) + sucrose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047600", "l": "abequosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802973", "l": "PLK3 phosphorylates CDC25C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20589", "l": "glutaryl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161791", "l": "15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190520", "l": "Association of Golgi  transport vesicles with microtubules (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24554", "l": "cholest-4-en-3-one + H(+) + NADPH => 5alpha-cholestan-3-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70592", "l": "PXLP-K259-GOT1 dimer deaminates L-Asp (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15222", "l": "a CDP-1,2-diacyl-sn-glycerol + H2O => a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31531", "l": "2-oxoglutarate + L-arginine + O2 = CO2 + N(omega)-hydroxy-L-arginine + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0042802", "l": "identical protein binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005260", "l": "intracellularly ATP-gated chloride channel activity"}, {"i": "MetaCyc:3.6.3.49-RXN"}, {"i": "EC:5.6.1.6", "l": "\"Channel-conductance-controlling ATPase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111237", "l": "Formation of ADAR1 homodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391935", "l": "DP1 receptor can bind PGD2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052749", "l": "glucose-6-phosphate dehydrogenase (coenzyme F420) activity"}, {"i": "KEGG.REACTION:R09550"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112430", "l": "Formation of P-TEFb complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56367", "l": "13-dihydrocarminomycin + H(+) + NADPH + O2 <=> carminomycin + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805470", "l": "AMPK phosphorylates TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390453", "l": "Hydrolysis of ATP and release of folded actin from CCT/TriC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31174", "l": "(3S)-hydroxytetradecanoyl-CoA <=> (2E)-tetradecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41683", "l": "a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+) <=> a 2-all-trans-polyprenylphenol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41630", "l": "cyclooctat-9-en-7-ol + diphosphate => geranylgeranyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029270", "l": "Recruitment of PLCgamma to membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24851", "l": "3-dehydroshikimate <=> 3,4-dihydroxybenzoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928645", "l": "EPHB:NMDAR binds TIAM1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60559", "l": "uridine(35) in tRNA(Tyr) <=> pseudouridine(35) in tRNA(Tyr)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31979", "l": "NADPH + O2 + trimethylamine = H2O + NADP(+) + trimethylamine N-oxide"}, {"i": "EC:1.14.13.148", "l": "\"Trimethylamine monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17463", "l": "D-sedoheptulose 7-phosphate + phosphate => H2O + sedoheptulose 1,7-bisphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.21", "l": "\"Keratan sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.136", "l": "\"Glucuronoarabinoxylan endo-1,4-beta-xylanase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10588", "l": "4 (R)-methylmalonyl-CoA + 12 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 8 NADPH = 4 CO2 + 4 CoA + 4 H2O + 8 NADP(+) + tetramethylated-mycocerosoyl-[mycocerosate synthase]"}, {"i": "RHEA:50352", "l": "3 (R)-methylmalonyl-CoA + 9 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 6 NADPH = 3 CO2 + 3 CoA + 3 H2O + 6 NADP(+) + trimethylated-mycocerosoyl-[mycocerosate synthase]"}, {"i": "EC:2.3.1.111", "l": "\"Mycocerosate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917987", "l": "TFRC dimer binds 2xholoTF (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58117", "l": "L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose => 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981713", "l": "C4b binds to cell surface (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40055", "l": "1,2,3-trioctanoylglycerol + H2O = 2,3-dioctanoyl-sn-glycerol + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427337", "l": "MBD2 binds methylcytosine in chromatin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17022", "l": "(2-aminoethyl)phosphonate + pyruvate => L-alanine + phosphonoacetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800490", "l": "ATM phosphorylates PIDD1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30994", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 24-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30253", "l": "2 a ubiquinone + n H(+)(out) + 2 H2O => 2 a ubiquinol + n H(+)(in) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24031", "l": "2-oxoglutarate + 4-(trimethylamino)butanoate + O2 <=> carnitine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938108", "l": "SERPINB13 binds cathepsin L (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061711", "l": "N(6)-L-threonylcarbamoyladenine synthase activity"}, {"i": "RHEA:37059", "l": "adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA"}, {"i": "EC:2.3.1.234", "l": "\"N(6)-L-threonylcarbamoyladenine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052602", "l": "4-chloronitrobenzene nitroreductase activity"}, {"i": "MetaCyc:RXN-8833"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72621", "l": "Ribosomal scanning  (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141423", "l": "Binding of the MCC complex to the APC/C complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183051", "l": "CBL ubiquitinates Sprouty (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37925", "l": "(8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate => (9Z,12Z,15Z)-octadecatrienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50898", "l": "(8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate => 8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54730", "l": "malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] => acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30575", "l": "3 menaquinone-8 + protoporphyrinogen IX = 3 menaquinol-8 + protoporphyrin IX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51031", "l": "2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 <=> 7-chloroindole-3-pyruvate imine dimer + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20941", "l": "1D-myo-inositol 1,3,4-trisphosphate + ATP => 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64483", "l": "4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate <=> (1S,3R,6R,8R,9R,11R,14S,15S,19R,20R)-8-ethyl-9,15-dihydroxy-3,4,6,20-tetramethyl-21,23-dioxo-24-azapentacyclo[20.2.1.0(1,6).0(11,20).0(14,19)]pentacosa-4,12,22(25)-trien-25-olate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29153", "l": "3 a ubiquinone(in) + 2 H2O(out) + NH4(+)(out) => 3 a ubiquinol(in) + 2 H(+)(out) + nitrite(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37920", "l": "(9Z,12Z)-octadecadienoate + O2 => (8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.44"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11517", "l": "H2O + succinyl-CoA => CoA + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48015", "l": "4-methyl-5-nitrocatechol + NADPH + O2 <=> 2-hydroxy-5-methylquinone + H(+) + H2O + NADP(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52480", "l": "16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase] = (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "RHEA:55024", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.50", "l": "\"Tabersonine 3-oxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140397", "l": "versiconal hemiacetal acetate esterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607753", "l": "CARD9 oligomerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48217", "l": "H(+) + hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050343", "l": "trans-2-enoyl-CoA reductase (NAD+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64836", "l": "2-phenylethanol + acetyl-CoA = CoA + phenethyl acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39285", "l": "a long-chain fatty acid(in) => a long-chain fatty acid(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24135", "l": "UDP-alpha-D-galactose <=> UDP-alpha-D-galactofuranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875374", "l": "MET binds LRIG1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3215295", "l": "USP7 deubiquitinates MDM2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0003880", "l": "protein C-terminal carboxyl O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694427", "l": "MIA3 binds procollagen VII (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420724", "l": "CASR binds Ca2+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15179", "l": "a fatty acid + H(+) + sn-glycerol 3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67093", "l": "ATP + docosanoate(in) + H2O => ADP + docosanoate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15139", "l": "H(+) + keto-L-tagatose 6-phosphate + NADH => galactitol 1-phosphate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005122", "l": "torso binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368119", "l": "Expression of CLOCK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38493", "l": "(9Z)-octadecenoate + glycerol + H(+) => 2-(9Z-octadecenoyl)-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665982", "l": "RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12280", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)"}, {"i": "EC:2.7.1.149", "l": "\"1-phosphatidylinositol-5-phosphate 4-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200143", "l": "AKT phosphorylates AKT1S1 (PRAS40) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27915", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46241", "l": "2 [Fe(II)-cytochrome b5] + a (9Z)-hexadecenoyl-containing glycerolipid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (9Z,12E)-hexadecadienoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13278", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate => [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31619", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose = dTDP-3-dehydro-6-deoxy-alpha-D-galactose + L-glutamate"}, {"i": "EC:2.6.1.90", "l": "\"dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852019", "l": "MET bound PI3K generates PIP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354289", "l": "AP-1:DSP1:STAT92E complex recruits RPD3 and represses transcription of the REL-68 target gene (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110215", "l": "Cleavage of uracil by UNG glycosylase (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855164", "l": "IP6 transports from the cytosol to the ER lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614367", "l": "HCMV Nuclear Pore Docking (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004964", "l": "luteinizing hormone receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731081", "l": "Syndecan-1 binds Integrin alphaVBeta5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2176445", "l": "SMURF2 binds SMAD2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31576", "l": "8-oxo-dGTP + H2O => 8-oxo-dGMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41041", "l": "1-O-hexadecyl-2-acetyl-3-dodecanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + dodecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64631", "l": "acetyl-CoA + octan-1-ol <=> CoA + octyl acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48114", "l": "H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine => N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32223", "l": "(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24045", "l": "3,4-dihydroxybenzoate + O2 => 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9709098", "l": "DHFR dimer reduces FOLA to DHF (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021478", "l": "WWC1 (Kibra) gene expression is stimulated by NOTCH3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22164", "l": "globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = globoside Forssman (d18:1(4E)) + H(+) + UDP"}, {"i": "EC:2.4.1.88", "l": "\"Globoside alpha-N-acetylgalactosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50331", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8935732", "l": "RUNX1 binds SIN3A,(SIN3B) co-repressor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11594", "l": "dihydromonacolin L carboxylate + H(+) + holo-[lovastatin nonaketide synthase] => dihydromonacolin L-[lovastatin nonaketide synthase] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65120", "l": "H2O + S-[(2E,6E,10E)-geranylgeranyl]-L-glutathione = L-glutamate + S-[(2E,6E,10E)-geranylgeranyl]-L-cysteinylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56395", "l": "[(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26476", "l": "alpha-D-galactose 1-phosphate + L-rhamnopyranose => beta-D-galactosyl-(1->4)-L-rhamnose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24076", "l": "a 3beta-hydroxy-Delta(5)-steroid + NAD(+) = a 3-oxo-Delta(5)-steroid + H(+) + NADH"}, {"i": "RHEA:43932", "l": "3beta-hydroxyandrost-5-en-17-one + NAD(+) = androst-5-ene-3,17-dione + H(+) + NADH"}, {"i": "EC:1.1.1.145", "l": "\"3-beta-hydroxy-Delta(5)-steroid dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28872", "l": "D-fructuronate(in) + H(+)(in) => D-fructuronate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381668", "l": "cAMP activates EPAC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39496", "l": "3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.3.2", "l": "\"NAD(P)H oxidase (H(2)O-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52060", "l": "12-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 12-hydroxyoctadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10589", "l": "4 (R)-methylmalonyl-CoA + 12 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 8 NADPH => 4 CO2 + 4 CoA + 4 H2O + 8 NADP(+) + tetramethylated-mycocerosoyl-[mycocerosate synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61280", "l": "4-aminobutanoate + H2O + O2 = H2O2 + NH4(+) + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3814838", "l": "Defective GYG1 is not autoglucosyolated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63727", "l": "candesartan + UDP-alpha-D-glucuronate <=> candesartan O-beta-D-glucuronoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176517", "l": "SULTs transfer (SO4)2- group to PREG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52069", "l": "9-(9Z-hexadecenoyloxy)-octadecanoate + H2O => (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050420", "l": "maltose synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17231", "l": "an acetyl ester + CoA => acetyl-CoA + an aliphatic alcohol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047849", "l": "dextransucrase activity"}, {"i": "MetaCyc:DEXTRANSUCRASE-RXN"}, {"i": "EC:2.4.1.5", "l": "\"Dextransucrase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22382", "l": "[(1->4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol => [(1->4)-alpha-D-galacturonosyl methyl ester](n) + n H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46667", "l": "corticosterone + H(+) + NADPH <=> 5beta-dihydrocorticosterone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21099", "l": "3-dehydroquinate <=> 3-dehydroshikimate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14405", "l": "D-glucose + NADP(+) = D-glucono-1,5-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38243", "l": "(9Z)-octadecenoyl-CoA + eicosan-1-ol = 1-O-eicosanyl (9Z)-octadecenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11946", "l": "2,5-dichlorocyclohexa-2,5-dien-1,4-diol + 2 chloride + 2 H(+) => (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0051752", "l": "phosphoglucan, water dikinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30285", "l": "(1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+) => (-)-trans-permethrin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202453", "l": "Auto-ubiquitination of TRAF6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005234", "l": "extracellularly glutamate-gated ion channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27886", "l": "2',3'-cyclic AMP + H2O = 3'-AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102057", "l": "jasmonoyl-valine synthetase activity"}, {"i": "MetaCyc:RXN-10457"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20898", "l": "ADP + H(+) + phosphate + urea-1-carboxylate => ATP + hydrogencarbonate + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40471", "l": "(2S)-methylpentadecanoyl-CoA + O2 = 2-methyl-(2E)-pentadecenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74716", "l": "Insulin binds the insulin receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665700", "l": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50872", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + O2 = (5,6,15R)-trihydroxy-(7E,9E,11Z,13E,17Z)-eicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052684", "l": "L-serine hydro-lyase (adding indole, L-tryptophan-forming) activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047283", "l": "dolichyl-phosphate D-xylosyltransferase activity"}, {"i": "MetaCyc:2.4.2.32-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33868", "l": "(S)-2-ureidoglycine + glyoxylate => glycine + N-carbamoyl-2-oxoglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-198714", "l": "ERK5 translocates to the nucleus (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54700", "l": "4-hydroxybenzoyl-5'-AMP + holo-[4-hydroxyphenylalkanoate synthase] = 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391157", "l": "p-4Y-SIRPA:CD47 binds SKAP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "71.944304668973928", "identifiers": [{"i": "GO:0031406", "l": "carboxylic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53102", "l": "2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine => 2-hydroxyestrone + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429699", "l": "CERT [ER] + ceramide [ER] => CERT:ceramide [ER] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928625", "l": "PAKs autophosphorylate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "81.790986234327661", "identifiers": [{"i": "GO:0016278", "l": "lysine N-methyltransferase activity"}, {"i": "REACT:R-HSA-6805740", "l": "SETD8 methylates TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44046", "l": "11,12-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45416", "l": "11-oxo-5Z,9,12E,14E-prostatetraenoate + H2O = 15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12865", "l": "1-methyladenosine + H2O = 1-methyladenine + D-ribose"}, {"i": "EC:3.2.2.13", "l": "\"1-methyladenosine nucleosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18496", "l": "benzoyl-CoA + glycine <=> CoA + H(+) + N-benzoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686711", "l": "Endocytois of SARS-CoV-1 Virion (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32596", "l": "7-isopropyl-4-methyloxepan-2-one + H2O => 6-hydroxy-3,7-dimethyloctanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034902", "l": "endosulfan sulfate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102497", "l": "scyllo-inositol dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606602", "l": "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163625", "l": "Glucagon binds to Glucagon receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45720", "l": "N-hexadecanoylsphing-4-enine(in) = N-hexadecanoylsphing-4-enine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22559", "l": "(S)-malate + A <=> AH2 + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.8", "l": "\"3'-phosphate/5'-hydroxy nucleic acid ligase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106335", "l": "tRNA (carboxymethyluridine(34)-5-O)-methyltransferase activity"}, {"i": "RHEA:43208", "l": "carboxymethyluridine(34) in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.229", "l": "\"tRNA (carboxymethyluridine(34)-5-O)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-196417", "l": "Reduction of desmosterol to cholesterol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30745", "l": "D-ribose + H(+) + nicotinamide => beta-nicotinamide D-riboside + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674414", "l": "Sorafenib-resistant PDGFR mutants don't bind sorefenib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.19", "l": "\"Ribonuclease T(2)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199299", "l": "AKT phosphorylates FOXO transcription factors (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53502", "l": "1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => 1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34073", "l": "N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP => trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042960", "l": "antimonite secondary active transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400219", "l": "Beta-TrCP1 binds phosphorylated PER proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26482", "l": "adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA"}, {"i": "EC:2.5.1.75", "l": "\"tRNA dimethylallyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11814", "l": "formaldehyde + H(+) + H2O2 + hydrogen sulfide => H2O + methanethiol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950260", "l": "Expression of Proteasome activator complex subunit 2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030332", "l": "cyclin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51014", "l": "a monoacylglycerol + H(+) + phosphocholine => a monoacyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63324", "l": "1,2-dihexadecanoyl-sn-glycerol + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936378", "l": "Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14155", "l": "17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucosiduronate + H(+) + UDP => 17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610752", "l": "GLI3R translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30325", "l": "beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => all-trans-beta-carotene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64663", "l": "a long-chain fatty acid + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39775", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 17,18-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21167", "l": "a carboxylic ester + H2O <=> a carboxylate + an alcohol + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030151", "l": "molybdenum ion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.n5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4549334", "l": "Defective DPAGT1 does not transfer GlcNAc to DOLP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31319", "l": "(2R)-3-phosphoglycerate + UDP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57137", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphoserine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31831", "l": "(2E,6E)-farnesyl diphosphate = delta-guaiene + diphosphate"}, {"i": "EC:4.2.3.93", "l": "\"Delta-guaiene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11310", "l": "ADP + H(+) + malonyl-CoA + phosphate => acetyl-CoA + ATP + hydrogencarbonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0019706", "l": "protein-cysteine S-palmitoyltransferase activity"}, {"i": "RHEA:36683", "l": "hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]"}, {"i": "EC:2.3.1.225", "l": "\"Protein S-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-164834", "l": "Enzyme-bound ATP is released (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2197691", "l": "WIP binds WASP,N-WASP, activating them (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53533", "l": "(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate => (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49795", "l": "eicosanoyl-CoA + glycine <=> CoA + H(+) + N-eicosanoylglycinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64047", "l": "(13Z)-docosenoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-(13Z-docosenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380216", "l": "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45475", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54603", "l": "2-oxoglutarate + O2 + octanoyl-CoA <=> 2-hydroxyoctanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30946", "l": "FAD + H(+) + octanoyl-CoA <=> (2E)-octenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951644", "l": "Release of mature NEDD8 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36291", "l": "3-methylxanthine + H(+) + NADPH + O2 = formaldehyde + H2O + NADP(+) + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008965", "l": "phosphoenolpyruvate-protein phosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047632", "l": "agmatine deiminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671993", "l": "CIT-3 binds DLG4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76500", "l": "TBXAS1 isomerises PGH2 to TXA2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626256", "l": "HSPA8:LAMP2a multimers depolymerizes to monomers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35076", "l": "doxorubicin(in) + H(+)(out) => doxorubicin(out) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33158", "l": "a 1-acyl-sn-glycero-3-phosphate + H2O <=> a 1-acyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139918", "l": "Phosphorylation of BIM by JNK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13423", "l": "an N-acylneuraminate 9-phosphate + phosphate => an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322434", "l": "XIAP dissociates from ub-TLE (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37526", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47312", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59649", "l": "D-xylotriono-1,5-lactone + H2O => D-xylotrionate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43311", "l": "1-hexadecanoyl-sn-glycerol + ATP <=> 1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12582", "l": "H(+) + NADH + pyruvate + taurine => H2O + NAD(+) + tauropine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54889", "l": "ATP + CoA + OPC-8 => AMP + diphosphate + OPC-8-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22384", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2160931", "l": "Disassembly of tight junctions (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38575", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28572", "l": "diphosphate + L-seryl-5'-AMP => ATP + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24954", "l": "ADP + H(+) + N-acetyl-D-muramate 6-phosphate => 1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016971", "l": "flavin-linked sulfhydryl oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54658", "l": "(2E)-geraniol => linalool"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12535", "l": "coenzyme B + methyl-coenzyme M <=> coenzyme M-coenzyme B heterodisulfide + methane"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358460", "l": "HPE SHH variants don't undergo autoproteolytic cleavage (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666426", "l": "CRKII:DOCK180:ELMO binds FCGR3A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58725", "l": "adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426147", "l": "SREBP1A,1C,2 binds the FDPS promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66205", "l": "heptanoyl-CoA + O2 => (2E)-heptenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010385", "l": "double-stranded methylated DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43830", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013158", "l": "CDC42 GDIs block activation of CDC42 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473594", "l": "Collagen type II degradation by MMP15 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851298", "l": "GPR143 binds L-Dopa (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65484", "l": "hexan-1-ol + hexanoyl-CoA = CoA + hexyl hexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43098", "l": "H(+) + N(1)-methylguanosine(2535) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(2535) in 23S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102428", "l": "kaempferol-3-O-glucoside 1,6-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-13830"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16359", "l": "AH2 + fumarate => A + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56969", "l": "dCTP + pyruvate => dCDP + H(+) + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50480", "l": "acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043917", "l": "ribose 1,5-bisphosphate isomerase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004743", "l": "pyruvate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53756", "l": "allodeoxycholoyl-CoA + cholate = allodeoxycholate + choloyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58746", "l": "diphosphate + H(+) + N(7)-methyl-GMP => H2O + N(7)-methyl-GTP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018657", "l": "toluene 3-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53429", "l": "a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] => a thymidine in DNA + S-methyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53465", "l": "1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21631", "l": "17alpha-hydroxyprogesterone + NADPH + O2 <=> acetate + androst-4-ene-3,17-dione + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538824", "l": "PP1 binds to phosphorylated TIM in complex with PER (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617853", "l": "GADD45A gene expression is stimulated by FOXO3,FOXO4,(FOXO1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607724", "l": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22761", "l": "Cypridina luciferin + O2 => CO2 + hnu + oxidized Cypridina luciferin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-167415", "l": "G-protein alpha subunit is inactivated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031700", "l": "adrenomedullin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390597", "l": "Release Of ADP From Myosin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13608", "l": "2 L-ascorbate + O2 <=> 2 H2O + 2 L-dehydroascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218821", "l": "PDK1 phosphorylates PKC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163770", "l": "Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50326", "l": "1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19533", "l": "2 H(+) + 2 H2O + N(2)-succinyl-L-arginine = CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+)"}, {"i": "EC:3.5.3.23", "l": "\"N-succinylarginine dihydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65094", "l": "aculene D + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase] => asperaculane G + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130731", "l": "Formation of COPII vesicle (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25709", "l": "H(+) + N,N-dihydroxy-L-dihomomethionine <=> (E)-5-(methylsulfanyl)pentanal oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22661", "l": "a fatty acid + ATP + holo-[ACP] => a fatty acyl-[ACP] + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62173", "l": "an N-acylethanolamine phosphate + H2O => an N-acylethanolamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62027", "l": "campesteryl 3-beta-D-glucoside + H2O <=> campesterol + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41662", "l": "NADH + sanguinarine => dihydrosanguinarine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10221", "l": "ATP + L-tyrosine + tRNA(Tyr) => AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50705", "l": "1-propanol + NAD(+) => H(+) + NADH + propanal"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043820", "l": "propionyl-CoA dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426223", "l": "Cation influx mediated by TRPC3/6/7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18798", "l": "a 3'-hydroxy,5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] => a 3',5'-dihydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213195", "l": "Formation of anchoring fibrils (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052861", "l": "glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683393", "l": "nsp15 binds nsp8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36533", "l": "(15Z)-3-oxotetracosenoyl-CoA + CO2 + CoA => (13Z)-docosenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42356", "l": "(9Z)-tetradecenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z)-hexadecenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-217255", "l": "FMO1:FAD N-oxidises TAM (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9607301", "l": "Active FLT3:GRB2 binds SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52439", "l": "a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + an acyl-CoA <=> 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40063", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O = 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36753", "l": "beta-D-Gal-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30031", "l": "(S)-muconolactone = cis,cis-muconate + H(+)"}, {"i": "EC:5.5.1.1", "l": "\"Muconate cycloisomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32990", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> a carboxylate + H(+) + sn-glycero-3-phospho-1D-myo-inositol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013009", "l": "RHOA binds effectors at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52823", "l": "L-serine + succinyl-CoA <=> CoA + O-succinyl-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19992", "l": "S-methyl-5-thio-alpha-D-ribose 1-phosphate <=> S-methyl-5-thio-D-ribulose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47224", "l": "3beta-sulfooxy-androst-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-sulfooxy-16alpha-hydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8857686", "l": "FITM1, FITM2 bind TAGs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59368", "l": "1-octadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoserine + 10-hydroxyoctadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41518", "l": "H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase] => O2 + phylloquinone + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0009883", "l": "red or far-red light photoreceptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31419", "l": "(2Z,6E)-farnesyl diphosphate = (-)-beta-curcumene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213017", "l": "Auto-ubiquitination of TRAF3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14446", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134953", "l": "DHX36 or DHX9 binds MyD88 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62313", "l": "salicylate + UDP-alpha-D-glucose => H(+) + salicylate 2-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "31.697897626293194", "identifiers": [{"i": "GO:0003674", "l": "molecular_function"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168635", "l": "PRKCB (PKC-beta) phosphorylates CARMA1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33865", "l": "fumarate + menaquinol-7 => menaquinone-7 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25809", "l": "H2O + O2 + spermidine => 3-aminopropanal + H2O2 + putrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62739", "l": "1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + dimethylallyl diphosphate <=> 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047631", "l": "ADP-ribose diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5340214", "l": "CYGB binds O2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18051", "l": "L-glutamate + N-acetyl-L-glutamate 5-semialdehyde => 2-oxoglutarate + N(2)-acetyl-L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24466", "l": "D-glyceraldehyde 3-phosphate + pyruvate => 2-dehydro-3-deoxy-6-phospho-D-galactonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47963", "l": "H2O + N(tele)-phospho-L-histidyl-[protein] <=> L-histidyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12354", "l": "H2O2 + L-xylo-hex-3-ulonolactone => L-gulono-1,4-lactone + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47137", "l": "ATP + CoA + lithocholate => AMP + diphosphate + lithocholoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43375", "l": "an N-acylsphing-4-enine + dTDP-alpha-D-glucose <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679044", "l": "FKBP1A binds sirolimus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112430", "l": "Formation of P-TEFb complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46102", "l": "cortisol + H2O + 2 oxidized [adrenodoxin] => 11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27369", "l": "acetoin + CoA + NAD(+) = acetaldehyde + acetyl-CoA + H(+) + NADH"}, {"i": "EC:2.3.1.190", "l": "\"Acetoin dehydrogenase system\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202137", "l": "AKT1 binds eNOS complex via HSP90 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40673", "l": "NH4(+) + pyruvate => 2-iminopropanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41523", "l": "menaquinone-4 + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + omega-hydroxymenaquinone-4 + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47986", "l": "diphosphate + hydroxysqualene => H2O + presqualene diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042169", "l": "SH2 domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3204303", "l": "MRE11 binds cytosolic DNA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004068", "l": "aspartate 1-decarboxylase activity"}, {"i": "MetaCyc:ASPDECARBOX-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63259", "l": "1-octadecanoyl-2-(15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63850", "l": "2 3',4'-dihydroxyaurone + 2 H2O => 2 2',3,4-trihydroxy-trans-chalcone + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036355", "l": "2-iminoacetate synthase activity"}, {"i": "MetaCyc:RXN-11319"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1013020", "l": "Activation of GIRK/Kir3 Channels (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39529", "l": "(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+) => (2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17077", "l": "H2O + N,N-dimethylglycine + O2 = formaldehyde + H2O2 + sarcosine"}, {"i": "EC:1.5.3.10", "l": "\"Dimethylglycine oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20638", "l": "D-fructose + D-glucose => D-glucono-1,5-lactone + D-sorbitol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113429", "l": "Elongating transcript encounters a lesion in the template (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2032775", "l": "YAP1 binds TEAD1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36560", "l": "A + cis-4-hydroxy-D-proline => 4-hydroxy-1-pyrroline-2-carboxylate + AH2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956684", "l": "ITCH polyubiquitinates TP73 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210444", "l": "L-Glutamate loading of synaptic vesicle (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17891", "l": "acetaldehyde + NH4(+) + phosphate => H2O + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877153", "l": "STARD7 binds PC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247836", "l": "Retromer recycles WLS to the Golgi (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52610", "l": "2-oxobutanoate + H(+) + NADPH => 2-hydroxybutanoate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60952", "l": "(E)-5-hydroxyferulate + S-adenosyl-L-methionine = E-sinapate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18767", "l": "a 1,2-diacyl-sn-glycerol + a sphingomyelin => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177946", "l": "Pro-EGF is cleaved to form mature EGF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43266", "l": "1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55403", "l": "7-cyano-7-carbaguanosine(15) in tRNA + NH4(+) <=> archaeosine(15) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40388", "l": "1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP => 1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36232", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O => 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43784", "l": "adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.286", "l": "\"25S rRNA (adenine(2142)-N(1))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.101", "l": "\"Xanthomonalisin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016692", "l": "NADH peroxidase activity"}, {"i": "KEGG.REACTION:R00090"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21356", "l": "L-arabinitol + NAD(+) = H(+) + L-ribulose + NADH"}, {"i": "EC:1.1.1.13", "l": "\"L-arabinitol 2-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17165", "l": "alpha-D-galactose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-D-galactose"}, {"i": "EC:2.7.7.32", "l": "\"Galactose-1-phosphate thymidylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031828", "l": "type 2C serotonin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.29"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682020", "l": "MRN complex binds shortened telomeres (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665998", "l": "MKL1 binds SRF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33190", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14512", "l": "2-oxoglutarate + mugineate + O2 <=> 3-epihydroxymugineate + CO2 + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53259", "l": "5alpha-cholest-7-en-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha,8alpha-epoxy-5alpha-cholestan-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18928", "l": "L-gulono-1,4-lactone + NADP(+) <=> D-glucurono-3,6-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196964", "l": "RFK:Mg2+ phosphorylates RIB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63093", "l": "H(+) + ilicicolin A + NADPH + O2 => H2O + ilicicolin A epoxide + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "77.02358060617253", "identifiers": [{"i": "GO:0140030", "l": "modification-dependent protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65674", "l": "a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontenoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12415", "l": "(2R)-3-phosphoglycerate + H2O <=> (R)-glycerate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371582", "l": "HSBP1 binds HSF1 trimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156910", "l": "Formation of eEF1B complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682598", "l": "ATM phosphorylates HERC2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41566", "l": "aclacinomycin T + dTDP + 2 H(+) => aklavinone + dTDP-beta-L-rhodosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11566", "l": "alpha-D-glucose 1-phosphate + D-gluconate => 4-O-beta-D-glucopyranosyl-D-gluconate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694524", "l": "nsp13 binds nsp12 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20972", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine = 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine"}, {"i": "EC:2.3.1.148", "l": "\"Glycerophospholipid acyltransferase (CoA-dependent)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16511", "l": "CO2 + formate => H(+) + oxalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62708", "l": "(indol-3-yl)butanoate + UDP-alpha-D-glucose = 4-(indol-3-yl)butanoyl-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11569", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP => 5-methyldeoxycytidine 5'-phosphate + 7,8-dihydrofolate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615490", "l": "p-S133-CREB1 binds MIR132 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928619", "l": "PAK1 binds RAC1:GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031624", "l": "ARC gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15070", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a => chlorophyllide a + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10869", "l": "a 1,2-diacyl-sn-glycerol + an acyl-CoA => a triacyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016631", "l": "enoyl-[acyl-carrier-protein] reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5679266", "l": "Beclin-1 complex translocates to the ER (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351849", "l": "Caspase-mediated cleavage of Etk (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22939", "l": "H2O + N-acetyl-D-glucosamine 6-phosphate <=> acetate + D-glucosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426209", "l": "DAG activation of TRPC channels (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782943", "l": "UV-DDB ubiquitinates XPC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26208", "l": "4-nitrophenol + H(+) + NADPH + O2 <=> 4-nitrocatechol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047239", "l": "hydroxymandelonitrile glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27559", "l": "(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate = all-trans-hexaprenyl diphosphate + 3 diphosphate"}, {"i": "EC:2.5.1.83", "l": "\"Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38015", "l": "delta-tocotrienol = 6-geranylgeranyl-2-methylbenzene-1,4-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26306", "l": "2-aminophenol + O2 => 2-aminomuconate 6-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684218", "l": "M protein oligomerization (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0008519", "l": "ammonium transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15235", "l": "[Fe(II)cytochrome c] + 2 H(+) + nitrite => [Fe(III)cytochrome c] + H2O + nitric oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57540", "l": "5'-NTP-ribonucleotide-RNA + H2O = 5'-phospho-ribonucleosidyl-ribonucleotide-RNA + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58098", "l": "glycerol + H(+) + tetracosanoate => 1-tetracosanoylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58768", "l": "1-O-(1Z-hexadecenyl)-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-O-(1Z-hexadecenyl)-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59235", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> diphosphate + hydropyrenol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047856", "l": "dihydrocoumarin hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5653957", "l": "Rag dimer formation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.24", "l": "\"Tocopherol cyclase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65110", "l": "aculene A + holo-[peptidyl-carrier protein] => aculene C + L-prolyl-[peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66593", "l": "(DNA)-(deoxyribonucleoside 5'-phosphate)-(deoxyribose 5'-phosphate)-(deoxyribonucleoside 5'-phosphate) => (DNA)-3'-(deoxyribonucleoside 5'-phosphate)-(2,3-dehydro-2,3-deoxyribose 5'-phosphate) + H(+) + phospho-5'-(DNA)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21674", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine => [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65568", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46041", "l": "2'-deoxycytidine + ATP => ADP + dCMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64162", "l": "ADP + phosphate + thioglycyl-[methyl-coenzyme M reductase] => ATP + glycyl-[methyl-coenzyme M reductase] + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396113", "l": "Dystroglycan binds AGRN and HSPG2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201630", "l": "Caspase-mediated cleavage of Acinus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65980", "l": "hnu + previtamin D3 = tachysterol 3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30272", "l": "2 (3,4-dimethoxyphenyl)methanol + H2O2 => 2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374723", "l": "Nociceptin receptor binds to nociceptin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867344", "l": "OMA1 hydrolyses OPA1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0052877", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, with a copper protein as acceptor"}, {"i": "EC:1.4.9.-", "l": "\"With a copper protein as acceptor\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008386", "l": "cholesterol monooxygenase (side-chain-cleaving) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19013", "l": "dTTP + H2O = dTDP + H(+) + phosphate"}, {"i": "EC:3.6.1.39", "l": "\"Thymidine-triphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11699", "l": "3'-demethylstaurosporine + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + staurosporine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429698", "l": "PRKD1,2,3 phosphorylates COL4A3BP-2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10849", "l": "an [alpha-factor](in) + ATP + H2O => ADP + an [alpha-factor](out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58232", "l": "L-seryl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33869", "l": "glycine + N-carbamoyl-2-oxoglycine => (S)-2-ureidoglycine + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43182", "l": "5-methylcytidine(2278) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(2278) in 25S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38491", "l": "2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15836", "l": "(S)-4-hydroxymandelate + H(+) + O2 <=> 4-hydroxybenzaldehyde + CO2 + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51041", "l": "indole-3-pyruvate imine dimer => chromopyrrolate + H(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10834", "l": "6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+) => a 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57937", "l": "H2O + isopyridoxal + NAD(+) => 5-pyridoxate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37921", "l": "(8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate => (9Z,12Z)-octadecadienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5689000", "l": "AADAC deacetylates PHEN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022399", "l": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0035033", "l": "histone deacetylase regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37861", "l": "1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052893", "l": "N1-acetylspermine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity"}, {"i": "RHEA:25996", "l": "H2O + N(1)-acetylspermine + O2 = H2O2 + N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23488", "l": "1,4-benzoquinone + H(+) + NADPH = hydroquinone + NADP(+)"}, {"i": "EC:1.6.5.6", "l": "\"p-benzoquinone reductase (NADPH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68595", "l": "ORC2 binds ORC3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669158", "l": "NF2 binds PAK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15334", "l": "(S)-ureidoglycolate + NADP(+) => H(+) + N-carbamoyl-2-oxoglycine + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40040", "l": "2 ATP + 2 L-glutamate + N-acetyl-L-aspartate => 2 ADP + 2 H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60796", "l": "2 2-oxoglutarate + gibberellin A53 + H(+) + 3 O2 = 3 CO2 + gibberellin A20 + 2 H2O + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34302", "l": "2'-deamino-2'-hydroxyneamine + 2-oxoglutarate <=> 2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50058", "l": "ADP + glycocholate(out) + H(+) + phosphate => ATP + glycocholate(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389862", "l": "Conversion of glyoxylate to oxalate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014293", "l": "RAC2 GDIs block activation of RAC2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-184392", "l": "N-myristoylation of GAG polyprotein by NMT2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22666", "l": "1,2-di-O-sinapoyl beta-D-glucose + D-glucose => 2 1-O-(trans-sinapoyl)-beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2029454", "l": "Autophosphorylation of PAK1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794349", "l": "NMDA receptor complex:DLG2,DLG3,DLG4 binds SPAR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25158", "l": "AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine => (R)-4'-phosphopantothenate + ATP + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373074", "l": "Receptor CCR9  binds CCL25 ligand (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32174", "l": "H(+) + NADPH + O2 + phenylacetyl-CoA <=> 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419011", "l": "Transhomodimerization of Nectins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640302", "l": "Asc.- radical dissociates to AscH- and DeHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64396", "l": "glycyl-sarcosine(out) + H(+)(out) = glycyl-sarcosine(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388828", "l": "PD-1 binds B7DC and B7H1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36965", "l": "3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoA => (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45930", "l": "4-hydroxy-6-(16-hydroxy-2-oxohexadecyl)pyran-2-one + 3 CO2 + 4 CoA => 15-hydroxypentadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625324", "l": "FOXO1 binds SREBF1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051474", "l": "glucosylglycerol transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678998", "l": "Endosomal TLRs pass through the Golgi (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52586", "l": "7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH => chenodeoxycholoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9681294", "l": "IL6R binds IL6R inhibitors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3240957", "l": "Formation of PRC2-EZH2 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1977959", "l": "ERBB4 forms heterodimers with EGFR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694409", "l": "Nucleotide exchange on RAB1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57282", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA => a guanosine in RNA + glyoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672304", "l": "IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17837", "l": "2-carboxy-D-arabinitol 1-phosphate + H2O = 2-carboxy-D-arabinitol + phosphate"}, {"i": "EC:3.1.3.63", "l": "\"2-carboxy-D-arabinitol-1-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874849", "l": "CREBRF binds CREB3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204850", "l": "Interaction of Tie2 and Dok-2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35134", "l": "H(+)(out) + L-alanyl-L-glutamate(out) <=> H(+)(in) + L-alanyl-L-glutamate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24611", "l": "5-dehydro-4-deoxy-D-glucarate + H(+) <=> 2,5-dioxopentanoate + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44610", "l": "2-methoxy-6-(all-trans-nonaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-nonaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392749", "l": "Transport of L1 into endosomes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682011", "l": "LC3 binds ATG7 dimer (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10377", "l": "ATP + Cu(2+)(in) + H2O => ADP + Cu(2+)(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20744", "l": "NADP(+) + prostaglandin D2 = 15-oxoprostaglandin D2 + H(+) + NADPH"}, {"i": "EC:1.1.1.196", "l": "\"15-hydroxyprostaglandin-D dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56140", "l": "H2O + S-adenosyl-L-methionine = adenosine + H(+) + L-methionine"}, {"i": "EC:3.13.1.8", "l": "\"S-adenosyl-L-methionine hydrolase (adenosine-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.47", "l": "\"Arabinofuranan 3-O-arabinosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229118", "l": "Defective SLC37A4 does not exchange G6P and Pi across the ER membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703439", "l": "FLT3 fusions recruit PIK3R1 through phosphorylated GAB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.35"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706287", "l": "Active FLT3 binds to ABL2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61420", "l": "(S)-8-oxocitronellyl enol = cis-cis-nepetalactol"}, {"i": "EC:5.5.1.35", "l": "\"(+)-cis,cis-nepetalactol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2299620", "l": "Collagen XI cross-links with collagen II (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800490", "l": "ATM phosphorylates PIDD1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54746", "l": "18-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954056", "l": "E2F6 binds TFDP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419861", "l": "Melanospin is stimulated by light (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786789", "l": "FLT3LG dimer binds FLT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23116", "l": "4-hydroxybenzoate + ATP + CoA = 4-hydroxybenzoyl-CoA + AMP + diphosphate"}, {"i": "EC:6.2.1.27", "l": "\"4-hydroxybenzoate--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18127", "l": "a 2-oxocarboxylate + AH2 + NH4(+) => A + a D-alpha-amino acid + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12398", "l": "dTDP-D-galacturonate + 3 H(+) + 2 NADPH => dTDP-D-galactose + H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40474", "l": "(2S)-methylpentadecanoyl-CoA + O2 <=> 2-methyl-(2E)-pentadecenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036200", "l": "3-ketosteroid 9-alpha-monooxygenase activity"}, {"i": "KEGG.REACTION:R09860"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389532", "l": "PP2A binds CTLA4 dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72095", "l": "Internal Methylation of mRNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51714", "l": "keto-D-fructose 6-phosphate => keto-D-tagatose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.9", "l": "\"dTMP kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432164", "l": "Ca2+ influx into the post-synaptic cell (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246444", "l": "SLC22A17 binds LCN2:2,5DHBA:Fe3+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17492", "l": "H(+) + NADH + O2 + phthalate <=> cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25146", "l": "3-hydroxy-L-kynurenine + H2O <=> 3-hydroxyanthranilate + H(+) + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866941", "l": "MID1IP1 binds THRSP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200406", "l": "CPT1A,B transfers PALM to CAR (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4088264", "l": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654623", "l": "Activated FGFR3 binds FRS3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19689", "l": "L-rhamnulose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate"}, {"i": "EC:4.1.2.19", "l": "\"Rhamnulose-1-phosphate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928619", "l": "PAK1 binds RAC1:GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60888", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine-phospho-ribonucleoside in mRNA + H2O = (N(7)-methyl 5'-triphospho-guanosine)-guanosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048244", "l": "phytanoyl-CoA dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48599", "l": "1,2-didecanoylglycerol + H2O <=> decanoate + decanoylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102157", "l": "(R)-sulfopropanediol 2-dehydrogenase activity"}, {"i": "MetaCyc:RXN-11729"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0031834", "l": "neurokinin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50999", "l": "L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2134506", "l": "TGFBR1 is recruited to tight junctions by PARD6A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001056", "l": "RNA polymerase III activity"}, {"i": "REACT:R-HSA-1964482", "l": "RNA polymerase III transcribes microbial dsDNA to dsRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043008", "l": "ATP-dependent protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191303", "l": "FDPS dimer transfers IPPP to GPP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032032", "l": "myosin I tail binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46807", "l": "a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine <=> a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52087", "l": "13-octadecanoyloxy-octadecanoate + H2O <=> 13-hydroxy-octadecanoate + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912406", "l": "p53 positively regulates transcription of MIR34 microRNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14658", "l": "aldehydo-D-ribose 5-phosphate => D-ribulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29975", "l": "2'-deoxycytidine(in) + H(+)(in) = 2'-deoxycytidine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41302", "l": "H2O + N-(9Z-octadecenoyl)-sphing-4-enine <=> (9Z)-octadecenoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012597", "l": "GOT2 dimer transfers amino group from L-Cys to 2OG to form 3MPYR and Glu (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23773", "l": "(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) => 2,3-dihydroxy-p-cumate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047403", "l": "lacto-N-biosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52164", "l": "O2 + phenylacetonitrile + reduced [NADPH--hemoprotein reductase] = (R)-mandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.77", "l": "\"Phenylacetonitrile alpha-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52390", "l": "4-O-phospho-D-threonate + ADP + H(+) => ATP + D-threonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22241", "l": "H2O + methylenediurea => N-(carboxyaminomethyl)urea + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804955", "l": "ATM phosphorylates MDM2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33009", "l": "(+)-artemisinic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (+)-artemisinic alcohol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672948", "l": "MARK3 phosphorylates KSR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.48"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694082", "l": "XK:KEL:Zn2+ cleaves EDN3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.79", "l": "\"Pappalysin-1\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034531", "l": "2-hydroxy-4-hydroxymethylbenzalpyruvate hydratase-aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37279", "l": "ATP + H2O + L-alanyl-L-histidine(out) = ADP + H(+) + L-alanyl-L-histidine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8963864", "l": "CUBN dissociates from 25(OH)D (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.20", "l": "\"Acyl-CoA hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66039", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ATP + H2O <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250880", "l": "botF HC:LC binds SV2A or B or C and GT1b on the target cell surface (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65891", "l": "2-oxoglutarate + 3-hydroxy-L-kynurenine <=> 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66743", "l": "ATP + H2O + N-acetyl-L-glutamate(in) <=> ADP + H(+) + N-acetyl-L-glutamate(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870678", "l": "Cleaved fibrinogen products bind TLR4:LY96 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27353", "l": "4'-demethylrebeccamycin + S-adenosyl-L-methionine = H(+) + rebeccamycin + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.164", "l": "\"Demethylrebeccamycin-D-glucose O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45773", "l": "[(1->4)-beta-D-mannosyl](n) + phosphate => [(1->4)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38570", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51989", "l": "(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => 18S-resolvin E1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47800", "l": "4-methylsulfanyl-2-oxobutanoate + an aromatic L-alpha-amino acid = an aromatic oxo-acid + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63070", "l": "2 CO2 + 3 CoA + triacetate lactone => acetyl-CoA + 2 H(+) + 2 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018817", "l": "RHOT1 GEFs activate RHOT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61470", "l": "a 5-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956365", "l": "ZBED1 (DREF) SUMOylates CHD3 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53532", "l": "(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate = (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047425", "l": "1-pyrroline-4-hydroxy-2-carboxylate deaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64593", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696275", "l": "RND2 binds GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20754", "l": "AH2 + 2 aquacob(III)alamin => A + 2 cob(II)alamin + 2 H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617643", "l": "HOXA3 mRNA is translated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50500", "l": "acetyl-CoA + N-terminal L-alanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64252", "l": "glycine + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012196", "l": "KPNA2 translation is negatively regulated by miR-26A and B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0016625", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor"}, {"i": "EC:1.2.7.-", "l": "\"With an iron-sulfur protein as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39360", "l": "(13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606602", "l": "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.18"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64122", "l": "a fatty acid + L-serine => an N-(fatty acyl)-L-serine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731924", "l": "EDNRA binds EDNs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26166", "l": "4'-hydroxyechinenone + A + H2O => AH2 + echinenone + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56852", "l": "reumycin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + toxoflavin"}]}
{"type": "biolink:MolecularActivity", "ic": "56.150635229200589", "identifiers": [{"i": "GO:1901363", "l": "heterocyclic compound binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25149", "l": "H(+) + H2O + quinolinate => (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49226", "l": "dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H(+) + H2O + oxidized [flavodoxin] => dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + reduced [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944254", "l": "Association of procollagen type XXVI (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990135", "l": "flavonoid sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166869", "l": "TRAF6 binds MEKK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36786", "l": "L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44922", "l": "(3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+) => (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54968", "l": "hexadecanoyl phosphate + sn-glycerol 3-phosphate = 1-hexadecanoyl-sn-glycero-3-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-983156", "l": "Polyubiquitination of substrate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16343", "l": "(R)-5-diphosphomevalonate + ADP => (R)-5-phosphomevalonate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57292", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O = a guanosine in RNA + glycolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17108", "l": "malonyl-[ACP] + S-adenosyl-L-methionine <=> malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44365", "l": "2-epi-5-epi-valiolone + ATP => 2-epi-5-epi-valiolone 7-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944263", "l": "Association of procollagen type II (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730902", "l": "Oligomerization of p-CARMA1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41429", "l": "L-tyrosine + S-adenosyl-L-methionine => 3-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65575", "l": "(-)-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-4'-desmethyl-deoxypodophyllotoxin + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9604767", "l": "FLT3LG dimer:FLT3 dimer autophosphorylates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174967", "l": "NAT2 acetylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031894", "l": "V1A vasopressin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3149539", "l": "MTR transfers CH3 group from MTHF to cob(I)alamin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27908", "l": "(2E)-butenoyl-CoA + H(+) + NADPH => butanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10083", "l": "dihydrophloroglucinol + NADP(+) <=> 1,3,5-trihydroxybenzene + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16988", "l": "3-oxoadipate + NADP(+) <=> H(+) + maleylacetate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032854", "l": "NTRK2 phosphorylates CDK5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52669", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate => [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169402", "l": "ISGylation of E2 conjugating enzymes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29857", "l": "D-alanine + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate => H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53409", "l": "(1S,4R)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 => (4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18969", "l": "a long-chain fatty acid + H(+) + hnu = a long-chain alkane + CO2"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0019903", "l": "protein phosphatase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32831", "l": "cob(III)alamin(in) = cob(III)alamin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982768", "l": "GH:GHR:JAK2 complex undergoes a conformational change (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56533", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine phosphate => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66534", "l": "diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] => ATP + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30382", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-beta-chamigrene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.5.-", "l": "\"Thiosulfotransferases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37842", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61122", "l": "2 H(+) + 2 H2O + myricetin + 2 oxidized [NADPH--hemoprotein reductase] => kaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195251", "l": "Assembly of the destruction complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23279", "l": "2-dehydropantoate <=> 3-methyl-2-oxobutanoate + formaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419644", "l": "Transphosphorylation of pLIMK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374896", "l": "Uptake of Noradrenaline (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21686", "l": "beta-alanine + H(+) + NADH + pyruvate => (R)-beta-alanopine + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871370", "l": "p-Y281,292-RUFY1 translocates from cytosol to early endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913374", "l": "Phosphorylated SHC1 recruits SHIP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.8"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047319", "l": "aspartate-phenylpyruvate transaminase activity"}, {"i": "RHEA:14097", "l": "3-phenylpyruvate + L-aspartate = L-phenylalanine + oxaloacetate"}, {"i": "EC:2.6.1.70", "l": "\"Aspartate--phenylpyruvate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45792", "l": "2-oxoglutarate + [ribosomal protein S23]-L-proline + O2 = [ribosomal protein S23]-trans-3-hydroxy-L-proline + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47022", "l": "[DsrC protein]-disulfide + 3 AH2 + 2 H(+) + sulfite => [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56904", "l": "an acyl-AMP + CoA = AMP + an acyl-CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25731", "l": "H(+) + N,N-dihydroxy-L-tetrahomomethionine = (E)-7-(methylsulfanyl)heptanal oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3244643", "l": "STING binds cyclic GMP-AMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166214", "l": "FA anion flip-flops to the opposite surface (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58878", "l": "4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43586", "l": "5-guanidino-2-oxopentanoate + NH4(+) => H2O + iminoarginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18332", "l": "(1S,3R,5S)-sabinol + NAD(+) <=> (1S,5S)-sabinone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26376", "l": "[thioredoxin]-disulfide + prostamide F2alpha <=> [thioredoxin]-dithiol + prostamide H2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791122", "l": "Expression of PDIA5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50730", "l": "4-hydroxyphenylacetonitrile + H2O => (Z)-(4-hydroxyphenyl)acetaldehyde oxime"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65455", "l": "ethanol + hexanoyl-CoA <=> CoA + ethyl hexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63550", "l": "angiotensin-(1-7) + L-phenylalanyl-L-histidine => angiotensin-(1-9) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40347", "l": "3-oxotetradecanedioyl-CoA + CoA = acetyl-CoA + dodecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9715355", "l": "lorlatinib-resistant ALK mutants don't bind lorlatinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45701", "l": "glycine betaine + H2O + O2 => formaldehyde + H2O2 + N,N-dimethylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56755", "l": "a 14alpha-methyl steroid + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> a Delta(14) steroid + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665697", "l": "ERBB2 TMD/JMD mutants hetrodimerize (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-209792", "l": "N-acetylation of serotonin (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52490", "l": "20-hydroxy prostaglandin E2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin E2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63467", "l": "(2E,6E,10E)-geranylgeraniol + UTP <=> (2E,6E,10E)-geranylgeranyl phosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60606", "l": "1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + choline => 1-tetradecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164834", "l": "Enzyme-bound ATP is released (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-112392", "l": "Resumption of elongation after recovery from pausing (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-445072", "l": "Interaction of PAK1 with Rac1-GTP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102525", "l": "2-oxoglutarate, L-arginine oxygenase (succinate-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54004", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682695", "l": "nsp13 helicase melts secondary structures in SARS-CoV-1 genomic RNA template (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8963872", "l": "VD3 translocates from ER membrane to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111913", "l": "Calmodulin binds CAMK4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1564112", "l": "Collagen type VI degradation by MMP2,9,11 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031870", "l": "thromboxane A2 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800253", "l": "TP53 binds the BCL6 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022911", "l": "CSPG is secreted (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66503", "l": "GDP-alpha-D-rhamnose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004463", "l": "leukotriene-A4 hydrolase activity"}, {"i": "MetaCyc:LEUKOTRIENE-A4-HYDROLASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66038", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ADP + H(+) + phosphate => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41455", "l": "5-methyl-1-naphthoate + H(+) + NADPH + O2 <=> 3-hydroxy-5-methyl-1-naphthoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35636", "l": "an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + UDP-alpha-D-glucose => an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786101", "l": "IL4 binds IL4R:JAK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62359", "l": "8-oxo-GDP + H2O <=> 8-oxo-GMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191656", "l": "Closure of gap junction (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0004629", "l": "phospholipase C activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604752", "l": "Initial activation of proMMP13 by MMP3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851298", "l": "GPR143 binds L-Dopa (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875443", "l": "USP8 deubiquitinates LRIG1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41694", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+) => 1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51929", "l": "H2O + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD(+) => (S)-2,3-diaminopropanoate + 2-oxoglutarate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45437", "l": "H2O + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine => H(+) + N-hexadecanoylethanolamine + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14208", "l": "carnosine + S-adenosyl-L-methionine <=> anserine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050464", "l": "nitrate reductase (NADPH) activity"}, {"i": "EC:1.7.1.3", "l": "\"Nitrate reductase (NADPH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433711", "l": "Cis-homodimerization of nectins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23949", "l": "4-hydroxybutanoate + NAD(+) => H(+) + NADH + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54147", "l": "2 2-oxoglutarate + 5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 O2 <=> 5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 CO2 + H2O + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047324", "l": "phosphoenolpyruvate-glycerone phosphotransferase activity"}, {"i": "RHEA:18381", "l": "dihydroxyacetone + phosphoenolpyruvate = dihydroxyacetone phosphate + pyruvate"}, {"i": "EC:2.7.1.121", "l": "\"Phosphoenolpyruvate--glycerone phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-947514", "l": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944257", "l": "Association of procollagen type XXIV (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635912", "l": "Expression of TRIB3 in response to stress (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199046", "l": "Ligands bind L-selectin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112690", "l": "PTPN11 binds CBL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508282", "l": "SYK is a substrate for JAK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18985", "l": "chorismate = isochorismate"}, {"i": "EC:5.4.4.2", "l": "\"Isochorismate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45603", "l": "D-galactaro-1,4-lactone <=> 5-dehydro-4-deoxy-D-glucarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176175", "l": "Stalling of DNA replication fork and RPA binding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12678", "l": "AH2 + Latia luciferin + 2 O2 => A + CO2 + formate + H(+) + H2O + hnu + oxidized Latia luciferin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30408", "l": "hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin] => oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33506", "l": "ATP + H2O + itraconazole(in) <=> ADP + H(+) + itraconazole(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35954", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate <=> diphosphate + N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40361", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551683", "l": "SUMOylation of TOPORS with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876446", "l": "p-ULK1 phosphorylates DENND3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38623", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26064", "l": "ATP + hygromycin B = 4-O-phosphohygromycin B + ADP + H(+)"}, {"i": "EC:2.7.1.163", "l": "\"Hygromycin B 4-O-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3244643", "l": "STING binds cyclic GMP-AMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.34", "l": "\"E2 NEDD8-conjugating enzyme\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036317", "l": "tyrosyl-RNA phosphodiesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14993", "l": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+)"}, {"i": "EC:2.3.1.85", "l": "\"Fatty-acid synthase system\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649733", "l": "mature p21 RAS binds GDP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156682", "l": "PLK1 phosphorylates NUDC (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018508", "l": "cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3204303", "l": "MRE11 binds cytosolic DNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12652", "l": "L-rhamnofuranose + NAD(+) <=> H(+) + L-rhamnono-1,4-lactone + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9035484", "l": "CysS248-MPST:TXN2 dissociates (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "81.790986234327661", "identifiers": [{"i": "GO:0016435", "l": "rRNA (guanine) methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64720", "l": "H(+)(out) + pyruvate(out) = H(+)(in) + pyruvate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20179", "l": "5'-O-beta-D-glucosylpyridoxine + H(+) + UDP => pyridoxine + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098608", "l": "methylselenol demethylase activity"}, {"i": "REACT:R-HSA-2408530", "l": "MeSeH is hydrolysed to H2Se by methylselenol demethylase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70481", "l": "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388855", "l": "Prolactin-releasing hormone receptor binds PRH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805470", "l": "AMPK phosphorylates TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48048", "l": "ganglioside GM1 (d18:1(4E)) + H2O = D-galactose + ganglioside GM2 (d18:1(4E))"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35772", "l": "5-deoxy-5-amino-3-dehydroshikimate => 3-amino-5-hydroxybenzoate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62090", "l": "2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + 2 H(+) + NADPH => D-glucosamine 6-phosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21108", "l": "(S)-3-methyl-2-oxopentanoate + H(+) = 2-methylbutanal + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45848", "l": "(3R)-3-hydroxydodecanoyl-CoA + NADP(+) = 3-oxododecanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791016", "l": "SFTPB binds itself (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022393", "l": "ANPEP hydrolyzes Angiotensin-(2-8) to Angiotensin-(3-8) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483186", "l": "PC is converted to PS by PTDSS1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9005980", "l": "IL21 binds IL21R:JAK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4411383", "l": "NLK phosphorylates TCF/LEF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417890", "l": "P2Y5 receptor can bind to LPA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52509", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58485", "l": "H2O + N-(acetyl)-sphing-4-enine => acetate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0016714", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen"}, {"i": "EC:1.14.16.-", "l": "\"With reduced pteridine as one donor, and incorporation of one atom of oxygen\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429698", "l": "PRKD1,2,3 phosphorylates COL4A3BP-2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61088", "l": "(S)-eriodictyol + 2-oxoglutarate + O2 = (2R,3R)-dihydroquercetin + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018649", "l": "tetrahydrofuran hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034512", "l": "box C/D RNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44026", "l": "(2E)-dodecenoyl-CoA + H2O => (3R)-3-hydroxydodecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062057", "l": "L-aspartate:fumarate antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950771", "l": "Expression of SOD1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34568", "l": "CDP-alpha-D-paratose + NADP(+) => CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64586", "l": "2-hydroxyethane-1-sulfonate(in) + Na(+)(in) => 2-hydroxyethane-1-sulfonate(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33492", "l": "2-hydroxyhexacosanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxyhexacosanoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35476", "l": "(1'S,5'S)-5'-hydroxyaverantin + NAD(+) => (S)-5'-oxoaverantin + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66256", "l": "ATP + H(+) + IC-asc-C7 = diphosphate + IC-asc-C7-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49157", "l": "dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine => dTDP-alpha-D-forosamine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28722", "l": "adenine(in) + H(+)(in) <=> adenine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034951", "l": "o-hydroxylaminobenzoate mutase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50130", "l": "17-oxoresolvin D1 + H(+) + NADH => NAD(+) + resolvin D1"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090614", "l": "5'-methylthioadenosine deaminase activity"}, {"i": "RHEA:25025", "l": "H(+) + H2O + S-methyl-5'-thioadenosine = NH4(+) + S-methyl-5'-thioinosine"}, {"i": "EC:3.5.4.31", "l": "\"S-methyl-5'-thioadenosine deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025033", "l": "NTF3 binds NTRK2 (TRKB) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23814", "l": "(1R,4S)-menthone + H(+) + NADPH => (+)-neomenthol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24055", "l": "a ubiquinone + reduced [electron-transfer flavoprotein] <=> a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64679", "l": "3-(methylsulfanyl)propanoyl-CoA + butan-1-ol <=> butyl 3-(methylsulfanyl)propanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032841", "l": "Activated NTRK2 binds CDK5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18080", "l": "L-arginyl-[dinitrogen reductase] + NAD(+) <=> H(+) + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62337", "l": "AMP + ATP => adenosine 3'-diphosphate,5'-phosphate + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977071", "l": "Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052892", "l": "aromatic (S)-hydroxynitrile lyase activity"}, {"i": "RHEA:54660", "l": "an aromatic (S)-hydroxynitrile = an aromatic aldehyde + hydrogen cyanide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.135"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22837", "l": "a fatty acyl-[ACP] + H(+) + malonyl-[ACP] => a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694665", "l": "SARS-CoV-2 gRNA:RTC:nascent RNA minus strand binds RTC inhibitors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617179", "l": "PRKACA phosphorylates TNNI3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3791155", "l": "Laminin-322 degradation by MMP14 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37156", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59843", "l": "(6S)-5,6,7,8-tetrahydrofolate + syringate <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-O-methylgallate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34503", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-epi-alpha-bisabolol + diphosphate"}, {"i": "EC:4.2.3.138", "l": "\"(+)-epi-alpha-bisabolol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52243", "l": "2 H2O + 2 Mn(2+) + O2 <=> 4 H(+) + 2 MnO2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000402", "l": "crossed form four-way junction DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018785", "l": "RHOBTB2 binds GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53547", "l": "chlorophyll a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 7(1)-hydroxychlorophyll a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008890", "l": "glycine C-acetyltransferase activity"}, {"i": "MetaCyc:AKBLIG-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23153", "l": "a ubiquinone + H(+) + NADH => a ubiquinol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46463", "l": "22R-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22R,7alpha)-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67022", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734687", "l": "ORC6 is phosphorylated on T195 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61443", "l": "acetyl-CoA + S-(2-succino)-L-cysteine <=> CoA + H(+) + N-acetyl-S-(2-succino)-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33568", "l": "A + ethanol => acetaldehyde + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12030", "l": "H(+) + N-carbamoyl-L-aspartate => H2O + L-5-carboxymethylhydantoin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32976", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + 2 H2O => 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37687", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668714", "l": "RAC1:GTP binds NOX1 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.7.-", "l": "\"With a iron-sulfur protein as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42717", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate => (2E)-thiogeraniol + 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799761", "l": "TP53 binds PPP1R13L (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33810", "l": "(E)-ferulate + H(+) <=> 2-methoxy-4-vinylphenol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32730", "l": "a very-long-chain acyl-CoA + H(+) + malonyl-CoA <=> a very-long-chain 3-oxoacyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29936", "l": "cytosine(in) + H(+)(in) => cytosine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685950", "l": "Endocytosis of protein 3a (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63663", "l": "(S)-8-amino-7-oxononanoate + CO2 + L-lysyl-[protein] <=> (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008718", "l": "D-amino-acid dehydrogenase activity"}, {"i": "RHEA:18125", "l": "A + a D-alpha-amino acid + H2O = a 2-oxocarboxylate + AH2 + NH4(+)"}, {"i": "MetaCyc:DAADEHYDROG-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13694", "l": "(6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694583", "l": "ABHD4 hydrolyses NAPE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65002", "l": "AMP + H(+) + octanoyl-[ACP] => holo-[ACP] + octanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48834", "l": "15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62119", "l": "H2O + iminosuccinate <=> NH4(+) + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63770", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycero-3-phosphoethanolamine => 2 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51664", "l": "D-5-phenylhydantoin + H2O = H(+) + N-carbamoyl-D-phenylglycine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047842", "l": "dehydro-L-gulonate decarboxylase activity"}, {"i": "RHEA:11084", "l": "3-dehydro-L-gulonate + H(+) = CO2 + L-xylulose"}, {"i": "EC:4.1.1.34", "l": "\"Dehydro-L-gulonate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9690493", "l": "RHOB binds effectors on endosomes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863858", "l": "SEC22B, CALR, STX4, TAP and TAPBP bind (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39398", "l": "3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42471", "l": "2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O <=> 2-oxopent-4-enoate + salicylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650473", "l": "SERPING1 is secreted (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209185", "l": "Monomeric PGN bound PGRP-LCx heterodimerises with PGRP-LCa at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51093", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30600", "l": "15-cis-phytoene + 3 A => 3 AH2 + all-trans-neurosporene"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042654", "l": "ecdysis-triggering hormone receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33026", "l": "6-phospho-D-gluconate + NAD(+) <=> CO2 + D-ribulose 5-phosphate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12237", "l": "H2O + NADP(+) + nicotinate => 6-hydroxynicotinate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17971", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine => ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182859", "l": "RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785524", "l": "Defective C1GALT1C1 does not bind C1GALT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46364", "l": "2 [Fe(II)-cytochrome b5] + an N-acylsphinganine + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + an N-acyl-(4R)-4-hydroxysphinganine + H2O"}, {"i": "RHEA:55808", "l": "2 [Fe(II)-cytochrome b5] + a dihydroceramide + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a phytoceramide + H2O"}, {"i": "EC:1.14.18.5", "l": "\"Sphingolipid C4-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31495", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP"}, {"i": "EC:2.4.1.274", "l": "\"Glucosylceramide beta-1,4-galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0003886", "l": "DNA (cytosine-5-)-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11039", "l": "ATP + H2O + quaternary ammonium(out) <=> ADP + H(+) + phosphate + quaternary ammonium(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32800", "l": "urea(in) => urea(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66627", "l": "cholest-4-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> (25S)-3-oxocholest-4-en-26-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54809", "l": "H(+) + L-isoleucine-(+)-7-isojasmonate + NADPH + O2 => H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "81.20444558259193", "identifiers": [{"i": "GO:0043211", "l": "ABC-type carbohydrate transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16674", "l": "3-phosphonopyruvate + H2O => H(+) + phosphate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48306", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+) => a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016206", "l": "catechol O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990259", "l": "histone-glutamine methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69068", "l": "RFC dissociates after sliding clamp formation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63695", "l": "alcohol glucuronate acceptor + UDP-alpha-D-glucuronate <=> a beta-D-glucuronoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48636", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O"}, {"i": "EC:4.2.1.152", "l": "\"Hydroperoxy icosatetraenoate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34084", "l": "a (3R)-3-hydroxyacyl-CoA => a (3S)-3-hydroxyacyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28714", "l": "H(+)(in) + N-(4-aminobenzoyl)-L-glutamate(in) <=> H(+)(out) + N-(4-aminobenzoyl)-L-glutamate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53531", "l": "1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-(9Z-octadecenoyl)-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114553", "l": "Activation of conventional Protein Kinase C (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59750", "l": "CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein] => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39963", "l": "2-hexadecanoylglycerol + H2O = glycerol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55813", "l": "a bacteriochlorophyllide d + H2O + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + a bacteriochlorophyllide f + 2 H(+) + 2 L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647631", "l": "GSDMD (1-275) binds PIPs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65030", "l": "(+)-6-hydroxypinoresinol + 2 H(+) + 2 reduced [azurin] => (+)-pinoresinol + H2O + 2 oxidized [azurin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22615", "l": "(3S)-citramalyl-CoA <=> acetyl-CoA + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5138432", "l": "DVL2 is phosphorylated by PKC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24997", "l": "N-hydroxy-L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12416", "l": "beta-alanyl-CoA = acryloyl-CoA + NH4(+)"}, {"i": "EC:4.3.1.6", "l": "\"Beta-alanyl-CoA ammonia-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60482", "l": "c-di-UMP + 2 diphosphate => 2 UTP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0101020", "l": "estrogen 16-alpha-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5444511", "l": "Formation of MSH2:MSH3 Complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62079", "l": "D-galactose 6-phosphate + NAD(+) <=> 6-phospho-D-galactono-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51596", "l": "2 H(+) + O2 + p-xylene + 2 reduced [2Fe-2S]-[ferredoxin] = 4-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17048", "l": "1,2-bis-(3,4-dimethoxyphenyl)propane-1,3-diol + H2O2 <=> 1-(3,4-dimethoxyphenyl)ethane-1,2-diol + 3,4-dimethoxybenzaldehyde + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16523", "l": "NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44463", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol <=> a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31127", "l": "3-O-methylgallate + O2 = 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56230", "l": "(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.1", "l": "\"Pepsin A\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007647", "l": "E2F6 binds CBX5 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2317332", "l": "PIP3 recruits AKT to the membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110211", "l": "NTHL1 glycosylase mediated recognition and binding of thymine glycol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14982", "l": "NADP(+) + testosterone => androst-4-ene-3,17-dione + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40633", "l": "2,3-dioctadecanoyl-sn-glycerol + H(+) + octadecanoate => H2O + trioctadecanoylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29305", "l": "2 H(+)(out) + succinate(out) => 2 H(+)(in) + succinate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6813749", "l": "ALDH1A1 oxidises GA to DGA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17229", "l": "acetyl-CoA + an aliphatic alcohol = an acetyl ester + CoA"}, {"i": "EC:2.3.1.84", "l": "\"Alcohol O-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211959", "l": "CYP3A43 6b-hydroxylates TEST (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63046", "l": "H(+) + mevinic carboxylate => H2O + mevastatin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25371", "l": "(2S)-2-amino-4-deoxychorismate + FMN = 3-(1-carboxyvinyloxy)anthranilate + FMNH2"}, {"i": "EC:1.3.8.16", "l": "\"2-amino-4-deoxychorismate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39940", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.36"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19248", "l": "N-phenylhydroxylamine <=> 2-aminophenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202692", "l": "PIP3 binds to RhoA and activates it (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14321", "l": "morphine + NADP(+) = H(+) + morphinone + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61824", "l": "pregnenolone + UDP-alpha-D-glucose = H(+) + pregnenolone 3-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199079", "l": "Epithelial cadherin binds to KLRG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451418", "l": "Pellino ubiquitinates IRAK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418553", "l": "cAMP degradation by Phosphodiesterases (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55960", "l": "4-(trimethylamino)butanoate + ATP + CoA = AMP + diphosphate + gamma-butyrobetainyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52011", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA <=> 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26419", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 => (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57704", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+) = 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008692", "l": "IL37(?-218) binds SMAD3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37648", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28349", "l": "7,8-dihydroneopterin 3'-triphosphate <=> 7,8-dihydromonapterin 3'-triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2263490", "l": "Defective GALNS does not hydrolyse sulfate from Gal6S in keratan sulfate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625416", "l": "Anterograde IFT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034573", "l": "didemethylisoproturon amidohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4332363", "l": "Autophosphorylation and activation of CAMK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196017", "l": "Dynamin is recruited to the gap junction plaque (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052615", "l": "ent-kaurene oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20023", "l": "amidinoproclavaminate + CO2 + succinate => 2-oxoglutarate + deoxyamidinoproclavaminate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001861", "l": "complement component C4b receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55227", "l": "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55736", "l": "alpha-D-galacturonosyl-[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n) + UDP-beta-L-rhamnose = [(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP"}, {"i": "EC:2.4.1.351", "l": "\"Rhamnogalacturonan I rhamnosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174916", "l": "Formation of N-glucuronides (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783681", "l": "LIF binds LIFR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49941", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2 => (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632804", "l": "SLC2A1 tetramer does not transport Glc from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36668", "l": "(15Z)-tetracosenoyl-CoA + sphinganine => CoA + H(+) + N-(15Z-tetracosenoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16351", "l": "A + chlorite + H2O => AH2 + chlorate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43997", "l": "2-oxoglutarate + a 3-methyl fatty acyl-CoA + O2 => a 2-hydroxy-3-methyl fatty acyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71495", "l": "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60432", "l": "A + cannabigerolate = AH2 + cannabichromenate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097258", "l": "20-hydroxy-leukotriene B4 omega oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030290", "l": "sphingolipid activator protein activity"}, {"i": "REACT:R-HSA-1605717", "l": "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28489", "l": "Fe(2+)(in) <=> Fe(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14442", "l": "acetyl-CoA + gentamicin C => CoA + H(+) + N(3)-acetylgentamycin C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374701", "l": "Phosphorylation of DCC by Fyn (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18216", "l": "alpha-D-glucose 1-phosphate + CTP + H(+) <=> CDP-D-glucose + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11678", "l": "D-ribonate + 2 H(+) + NADPH => D-ribose + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18902", "l": "H(+) + H2O + N-benzyloxycarbonyl-L-leucine => benzyl alcohol + CO2 + L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10104", "l": "2-oxoglutarate + gibberellin A20 + O2 = CO2 + gibberellin A1 + succinate"}, {"i": "EC:1.14.11.15", "l": "\"Gibberellin 3-beta-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0042947", "l": "glucoside transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174445", "l": "RPA binds to the Flap on the C-strand (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53613", "l": "CTP + D-ribulose 5-phosphate + H(+) => CDP-D-ribulose + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0004022", "l": "alcohol dehydrogenase (NAD+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46060", "l": "(11E)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (5Z,11E)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16766", "l": "D-mannitol + NADP(+) => D-fructose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008142", "l": "oxysterol binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31616", "l": "dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-adenosyl-L-methionine => dTDP-D-ravidosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54701", "l": "4-hydroxybenzoyl-5'-AMP + holo-[4-hydroxyphenylalkanoate synthase] => 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798081", "l": "TP53 family members stimulate CASP1 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19641", "l": "(E)-4-coumarate + ATP + CoA = (E)-4-coumaroyl-CoA + AMP + diphosphate"}, {"i": "EC:6.2.1.12", "l": "\"4-coumarate--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18288", "l": "an N-acyl-D-aspartate + H2O <=> a carboxylate + D-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.73", "l": "\"Inosine/xanthosine triphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197963", "l": "DHFR2 reduces FOLA to DHF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332388", "l": "Activation of MAP3K7 in response to WNT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42641", "l": "a 2-demethylmenaquinol + S-adenosyl-L-methionine => a menaquinol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56254", "l": "H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-seryl-[protein] + UDP => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49422", "l": "ADP + H(+) + valienone 7-phosphate => ATP + valienone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432164", "l": "Ca2+ influx into the post-synaptic cell (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64657", "l": "(E)-sinapoaldehyde + CoA + NADP(+) => (E)-sinapoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16370", "l": "(R)-lactate + NAD(+) => H(+) + NADH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59497", "l": "(20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + O2 + reduced [NADPH--hemoprotein reductase] => (20S)-ginsenoside C-K + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37247", "l": "H2O + thymidine 3'-monophosphate = phosphate + thymidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186819", "l": "SH2 domain of Src binds to the active receptor (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036136", "l": "kynurenine-oxaloacetate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645220", "l": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19707", "l": "H(+) + hexadecanoyl-CoA + NADH => CoA + hexadecanal + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40847", "l": "eicosanoyl-CoA + FAD + H(+) = (2E)-eicosenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050506", "l": "vomilenine glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042610", "l": "CD8 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25935", "l": "4-methylquinoline + A + H2O <=> 4-methylquinolin-2(1H)-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237119", "l": "Acireductone is oxidized to MOB (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202164", "l": "Translocation of PDK1 to Plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15842", "l": "D-glucose 6-phosphate + NADP(+) => 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48190", "l": "(2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein] => (9Z,12Z)-octadecadienoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37326", "l": "glycyl-L-methionine + H2O <=> glycine + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39896", "l": "7-deoxyloganetate + UDP-alpha-D-glucose => 7-deoxyloganate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.147", "l": "\"16-alpha-hydroxysteroid dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3215426", "l": "COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41675", "l": "1-O-hexadecyl-sn-glycerol + ATP <=> 1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168910", "l": "RIP1 facilitates IKK complex phosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42580", "l": "ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18587", "l": "dihydroxyacetone phosphate => D-glyceraldehyde 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805126", "l": "AURKB phosphorylates TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34370", "l": "acrylamide + H2O <=> acrylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018802", "l": "2,4-dihydroxyhept-2-ene-1,7-dioate aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50680", "l": "H2O + N-terminal L-glutaminyl-[protein] = N-terminal L-glutamyl-[protein] + NH4(+)"}, {"i": "EC:3.5.1.122", "l": "\"Protein N-terminal glutamine amidohydrolase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030145", "l": "manganese ion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38461", "l": "2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose + CoA => 2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + a mycolipenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.77"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2012087", "l": "Autocatalytic phosphorylation of FGFR4 Y367C mutant (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15674", "l": "acetoacetyl-CoA + H2O => acetoacetate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042943", "l": "D-amino acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202500", "l": "Activation of IKK complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19973", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = H(+) + S-methyl-5'-thioadenosine + spermine"}, {"i": "EC:2.5.1.22", "l": "\"Spermine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684008", "l": "NBN binds KPNA2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0050486", "l": "intramolecular transferase activity, transferring hydroxy groups"}, {"i": "EC:5.4.4.-", "l": "\"Transferring hydroxy groups\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65698", "l": "a diacylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61592", "l": "H2O + L-cysteinyl-[sulfatase] + S-adenosyl-L-methionine = 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + 2 H(+) + hydrogen sulfide + L-methionine"}, {"i": "EC:1.8.98.7", "l": "\"Cysteine-type anaerobic sulfatase-maturating enzyme\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981355", "l": "RASA1 binds RAS:GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004305", "l": "ethanolamine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004834", "l": "tryptophan synthase activity"}, {"i": "KEGG.REACTION:R02722"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24012", "l": "gamma-tocopherol + S-adenosyl-L-methionine = (+)-alpha-tocopherol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694527", "l": "Loss of SAR1B GTPase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41613", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O => D-ribose 2,5-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61820", "l": "3beta-hydroxy-5alpha-androstan-17-one + UDP-alpha-D-glucose = epiandrosterone 3-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23828", "l": "2-dehydro-D-gluconate + NADP(+) = 2,5-didehydro-D-gluconate + H(+) + NADPH"}, {"i": "EC:1.1.1.274", "l": "\"2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18671", "l": "adenine + D-ribose => adenosine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29600", "l": "monacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + monacolin J carboxylate + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65073", "l": "(2E,6E)-farnesyl diphosphate => dauca-4,7-diene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798749", "l": "Exocytosis of specific granule lumen proteins (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.31", "l": "\"Ananain\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9688838", "l": "RIPK3 binds STUB1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683792", "l": "p-T68-CHEK2 autophosphorylates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20259", "l": "3-methyleneoxindole + H(+) + NADPH => 3-methyloxindole + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20133", "l": "3-(indol-3-yl)lactate + NAD(+) = H(+) + indole-3-pyruvate + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047339", "l": "nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47838", "l": "[5-(aminomethyl)furan-3-yl]methyl diphosphate + ADP => [5-(aminomethyl)-3-furyl]methyl phosphate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.98.-", "l": "\"With other, known, acceptors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50068", "l": "ATP + glycoursodeoxycholate(in) + H2O = ADP + glycoursodeoxycholate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2895778", "l": "POU5F1 (OCT4), STAT3 bind the SALL4 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13541", "l": "H2O + tetrathionate = H(+) + sulfate + sulfur + thiosulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11281", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O => (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dCMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66838", "l": "asperterpenoid A + 5 H(+) + 5 H2O + 4 oxidized [NADPH--hemoprotein reductase] => 4 O2 + preasperterpenoid A + 4 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030977", "l": "taurine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21887", "l": "H2O + trithionate <=> H(+) + sulfate + thiosulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10965", "l": "ATP + D-xylulose => ADP + D-xylulose 5-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691167", "l": "CUL1, SKP1, FBXL5 bind (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5681987", "l": "LC3 is cleaved by ATG4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1614614", "l": "Cysteine is degraded to serine and H2S (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44918", "l": "(3E)-decenoyl-CoA + NADP(+) => (2E,4E)-decadienoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034869", "l": "2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005274", "l": "allantoin:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004039", "l": "allophanate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59390", "l": "a fatty acid + an aliphatic alcohol + H(+) => a fatty acid ester + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353314", "l": "XP-C-RAD23B heterodimer binds to damaged DNA site with lesion (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627104", "l": "XIAP binds CASP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26445", "l": "a ubiquinone + ethanol <=> a ubiquinol + acetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200396", "l": "Creatine transport across the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20440", "l": "5D-5-O-methyl-chiro-inositol + NADP(+) <=> 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102595", "l": "cyanidin 7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) acyltransferase (acyl-glucose dependent) activity"}, {"i": "MetaCyc:RXN-15374"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209536", "l": "IkB is ubiquitinated and degraded (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909720", "l": "IFN alpha/beta binds to IFNAR2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53964", "l": "4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + ribostamycin = gamma-L-glutamyl-butirosin B + H(+) + holo-[BtrI ACP]"}, {"i": "EC:2.3.2.19", "l": "\"Ribostamycin:4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] 4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoate transferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043889", "l": "(S)-3-O-geranylgeranylglyceryl phosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798749", "l": "Exocytosis of specific granule lumen proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0015106", "l": "bicarbonate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30241", "l": "n a quinol + n sulfur => n a quinone + n H(+) + n hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021609", "l": "ESR-associated SRC autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0051766", "l": "inositol trisphosphate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399711", "l": "Activation of Ca impermeable AMPA receptors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32881", "l": "(1R,4R)-bornane-2,5-dione + H(+) + NADH => (1R,4R,5R)-5-hydroxycamphor + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2169046", "l": "Degradation of TGF-beta receptor complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62942", "l": "acetate + cytosine + H(+) => H2O + N(4)-acetylcytosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941701", "l": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "64.054900825907879", "identifiers": [{"i": "GO:0052689", "l": "carboxylic ester hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11942", "l": "CO2 + L-ornithine + NH4(+) => 2 H(+) + H2O + L-citrulline"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036370", "l": "D-alanyl carrier activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160851", "l": "HAS1,2,3 mediate the polymerisation of HA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51632", "l": "all-trans-(4S)-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-(4S,16)-dihydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20910", "l": "3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP => 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36623", "l": "3-phenylpyruvate + S-adenosyl-L-methionine = (3S)-2-oxo-3-phenylbutanoate + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.281", "l": "\"Phenylpyruvate C(3)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450533", "l": "PKCdelta phosphorylates HuR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866851", "l": "CFTR transits to the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693536", "l": "ATM phosphorylates MDC1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6803890", "l": "SFN dimerizes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102339", "l": "3-oxo-arachidoyl-CoA reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10503", "l": "butanoyl-CoA + glyoxylate + H2O <=> 3-ethylmalate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29636", "l": "alpha-maltopentaose + H2O => alpha-D-glucose + alpha-maltotetraose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17318", "l": "chlorophyllide a + H(+) + phytyl diphosphate => chlorophyll a + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15814", "l": "1H-imidazole + acetyl-CoA => CoA + N-acetylimidazole"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33082", "l": "6-amino-6-deoxyfutalosine + H2O <=> adenine + dehypoxanthine futalosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38854", "l": "H(+) + tetracenomycin F2 <=> H2O + tetracenomycin F1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21230", "l": "beta-maltose => alpha-maltose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655233", "l": "Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5628871", "l": "BRD7 promotes EP300-mediated acetylation of TP53 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51468", "l": "(R)-lactate + a quinone = a quinol + pyruvate"}, {"i": "EC:1.1.5.12", "l": "\"D-lactate dehydrogenase (quinone)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46883", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11081", "l": "dTMP + H2O => phosphate + thymidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29259", "l": "(2R,3R)-tartrate(out) + succinate(in) = (2R,3R)-tartrate(in) + succinate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-982810", "l": "JAK2 phosphorylation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64921", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + H2O => a 2'-deoxyribonucleoside 5'-phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950322", "l": "Expression of ribosomal protein lateral stalk subunit P0 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265936", "l": "Phosphorylation of RPA2 by CDC2 kinase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683751", "l": "M protein gets N-glycosylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27316", "l": "2 CO2 + dichloroarcyriaflavin A + 6 H2O + 4 NAD(+) => dichlorochromopyrrolate + 6 H(+) + 4 NADH + 4 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48318", "l": "a ganglioside GD1alpha + CMP + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1b"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102853", "l": "1-18:1-2-18:1-sn-glycerol-3-phosphocholine desaturase activity"}, {"i": "MetaCyc:RXN-8320"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033221", "l": "ATPase-coupled urea transmembrane transporter activity"}, {"i": "RHEA:32803", "l": "ATP + H2O + urea(out) = ADP + H(+) + phosphate + urea(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047082", "l": "3,9-dihydroxypterocarpan 6a-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55769", "l": "all-trans-retinoate + UDP-alpha-D-glucuronate => all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58334", "l": "(E)-non-2-enal + H(+) + NADPH => (E)-non-2-en-1-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61097", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] => (S)-eriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10645", "l": "2-oxo-2H-pyran-4,6-dicarboxylate + H2O => (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443774", "l": "Trans-homodimerization of Neurofascin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111966", "l": "GRK2 binds CALM1:4Ca2+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848939", "l": "PTK6 binds KHDRBS1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9677579", "l": "CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37913", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA => (9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2990882", "l": "CDK1 phosphorylates NUP98 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417077", "l": "Recruitment of telomerase RNP to a telomeric chromosome end (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10983", "l": "L-serine <=> D-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665524", "l": "ATP translocates from cytosol to extracellular space (stimuated by C3AR1:C3a) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036220", "l": "ITP diphosphatase activity"}, {"i": "RHEA:29399", "l": "H2O + ITP = diphosphate + H(+) + IMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473584", "l": "Collagen type III degradation by MMP15 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676926", "l": "Methionine sulfoxide is oxidised to methionine sulfone (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.2.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40771", "l": "(20S)-ginsenoside Rg1 + H2O = (20S)-ginsenoside F1 + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008921", "l": "lipopolysaccharide-1,6-galactosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24281", "l": "myricetin + 2 S-adenosyl-L-methionine => 2 H(+) + 2 S-adenosyl-L-homocysteine + syringetin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214864", "l": "Phosphorylated CACT and DL/DIF dimer dissociate from the TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.66", "l": "\"Beta-selinene cyclase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28515", "l": "(R)-carnitine + ATP + CoA => (R)-carnitinyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22535", "l": "(2E)-octenedioyl-CoA + H2O <=> (3S)-hydroxyoctanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863914", "l": "Transport of SEC22B, TAP and PLC from ER to ERGIC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390329", "l": "Dephosphorylation of AKT by PP2A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70899", "l": "histidine => urocanate + NH4+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004313", "l": "[acyl-carrier-protein] S-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418904", "l": "A1 and A3 receptors bind adenosine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37252", "l": "cysteamine S-phosphate + H2O => cysteamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444171", "l": "Receptor FFAR2 binds carboxylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165034", "l": "Rev multimer-bound  HIV mRNA:CRM1 complex associates with Ran:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12146", "l": "cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + H(+) + UDP => cyanidin 3-O-rutinoside + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40795", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64079", "l": "3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 <=> 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30181", "l": "2 CO2 + reduced 2[4Fe-4S]-[ferredoxin] => oxalate + oxidized 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39244", "l": "(11Z)-3-oxoicosenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z)-eicosenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390674", "l": "ADRB1 bind ADR,NAd (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56892", "l": "H(+) + NADPH + UDP-4-dehydro-beta-L-rhamnose = NADP(+) + UDP-beta-L-rhamnose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28805", "l": "3-dehydro-L-gulonate 6-phosphate => H2O + L-ascorbate 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635845", "l": "GLI proteins bind CDC73 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39109", "l": "(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47206", "l": "16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21003", "l": "1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene <=> 1,2,3,5-tetrahydroxybenzene + 1,3,5-trihydroxybenzene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390597", "l": "Release Of ADP From Myosin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27801", "l": "(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate <=> all-trans-octaprenyl diphosphate + 5 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58010", "l": "(20S)-ginsenoside Rg1 + H(+) + UDP => (20S)-ginsenoside F1 + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46328", "l": "L-threo-3-phenylserine = 3-phenylpyruvate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610752", "l": "GLI3R translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30121", "l": "dodecanoate + H(+) + holo-[ACP] => dodecanoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698925", "l": "Packaging of Viral Genome Into C Capsids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5682377", "l": "LC3 de-lipidation by ATG4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850534", "l": "PDCL promotes G-protein beta 5 folding (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382054", "l": "PDGF binds to extracellular matrix proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56442", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3095889", "l": "MMACHC reduces Cbl (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49013", "l": "aurachin C + H(+) + NADH + O2 => aurachin C epoxide + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66600", "l": "2 dopamine + O2 = 2 dopamine quinone + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202127", "l": "eNOS synthesizes NO (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008801", "l": "beta-phosphoglucomutase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55666", "l": "2 A + canthaxanthin + 3 H2O => 2 AH2 + echinenone + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38807", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30057", "l": "(2S)-2-amino-3-oxobutanoate + H(+) + NADPH => L-allo-threonine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12115", "l": "indole-3-pyruvate + S-adenosyl-L-methionine <=> (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38793", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.114", "l": "\"Equine arterivirus serine peptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189406", "l": "4 PBGs bind to form HMB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13121", "l": "ATP + shikimate = 3-phosphoshikimate + ADP + H(+)"}, {"i": "EC:2.7.1.71", "l": "\"Shikimate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65278", "l": "2alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41478", "l": "CoA + zymosterol ester => 5alpha-cholesta-8,24-dien-3beta-ol + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45627", "l": "ATP + holo-[CmaA peptidyl-carrier protein] + L-alloisoleucine <=> AMP + diphosphate + L-alloisoleucyl-[CmaA peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5631941", "l": "SESN1,2,3 bind AMPK (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695841", "l": "FLT3 mutant dimers bind GRB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005534", "l": "galactose binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66753", "l": "(2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(in) + ATP + H2O => (2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33293", "l": "(E)-8-(methylsulfanyl)octanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-pentahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38013", "l": "chlorophyllide a + H(+) + phytol => chlorophyll a + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17366", "l": "ATP + H2O + Mn(2+)(out) => ADP + H(+) + Mn(2+)(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25987", "l": "(+)-epi-isozizaene + H(+) + NADPH + O2 <=> (5R)-albaflavenol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60135", "l": "a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 <=> a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57043", "l": "aldehydo-D-apiose <=> D-apiofuranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54126", "l": "CO2 + excited coelenteramide h monoanion + H(+) => coelenterazine h dioxetanone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0008512", "l": "sulfate:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63321", "l": "a glycerophospholipid(in) + ATP + H2O => a glycerophospholipid(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1606789", "l": "ARSB hydrolyses DS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390930", "l": "5-HT2 receptor can bind serotonin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700156", "l": "Active ALK dimer binds IRS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507870", "l": "Aquaporins passively transport water out of cells (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.4", "l": "\"Nitrate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.46", "l": "\"Glycerophosphodiester phosphodiesterase\""}]}
{"type": "biolink:MolecularActivity", "ic": "80.661393760018115", "identifiers": [{"i": "GO:0004312", "l": "fatty acid synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28495", "l": "a menaquinone + dimethyl sulfide + H2O => a menaquinol + dimethyl sulfoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702510", "l": "FLT mutants bind type II TKIs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167136", "l": "Addition of nucleotides 5 through 9 on the growing HIV-1 transcript (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879311", "l": "mycothiol S-conjugate is cleaved into mercapturic acid and GlcN-Ins (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61596", "l": "[DsbD protein]-dithiol + [thioredoxin]-disulfide = [DsbD protein]-disulfide + [thioredoxin]-dithiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36077", "l": "A + an N-acylsphing-4-enine + 2 H2O => AH2 + an N-acylsphinganine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265177", "l": "Exocyst complex formation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55734", "l": "19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+) => 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42014", "l": "11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + H(+) + NADH => cortisol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944219", "l": "Association of procollagen type XVI (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428750", "l": "Gq activation by TP receptor (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26529", "l": "a (3R)-3-hydroxyacyl-CoA <=> a (2E)-enoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031435", "l": "mitogen-activated protein kinase kinase kinase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627106", "l": "SMAC (DIABLO) forms dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29973", "l": "2'-deoxyinosine(out) + H(+)(out) => 2'-deoxyinosine(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39067", "l": "3-oxooctanedioyl-CoA + CoA = acetyl-CoA + hexanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44486", "l": "3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63757", "l": "flavokermesate + UDP-alpha-D-glucose => flavokermesate 7-C-beta-D-glucoside + 2 H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013109", "l": "RHOC GEFs activate RHOC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191299", "l": "Squalene is oxidized to its epoxide (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15889", "l": "H2O + L-glutamine = L-glutamate + NH4(+)"}, {"i": "EC:3.5.1.2", "l": "\"Glutaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48151", "l": "ganglioside GT1b (d18:1(4E)/18:0) + H2O <=> ganglioside GD1b(d18:1(4E)/18:0) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191072", "l": "Synthesis of Cx43 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399978", "l": "Protein kinase C, alpha type phosphorylates MARCKS (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685604", "l": "SLAMF6 binds SLAMF6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11391", "l": "an 11beta-hydroxysteroid + NADP(+) <=> an 11-oxosteroid + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49297", "l": "keto-L-sorbose(out) + N(pros)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + L-sorbose 1-phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25292", "l": "acetaldehyde + H(+) + NADH => ethanol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951644", "l": "Release of mature NEDD8 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191636", "l": "Phosphorylation of Cx43 by c-src (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47786", "l": "5-methylcytidine(3782) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(3782) in 28S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39933", "l": "(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61574", "l": "(15S)-hydroperoxy-(11Z,13E)-eicosadienoate => (11Z,14Z)-eicosadienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687097", "l": "p-S857 NCOA3 binds ETV4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59728", "l": "(2R)-ethylmalonyl-CoA = (2S)-ethylmalonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683593", "l": "ATG7:ATG3:LC3 dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805035", "l": "TP53 binds STK11 and NUAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25539", "l": "ent-copalyl diphosphate <=> diphosphate + ent-sandaracopimara-8(14),15-diene"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004394", "l": "heparan sulfate 2-O-sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33280", "l": "L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000074", "l": "TCII binds Cbl in the circulation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29587", "l": "4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) = 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH"}, {"i": "EC:1.1.1.312", "l": "\"2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683774", "l": "p-T68-CHEK2 dimerizes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404193", "l": "IGF1R phosphorylates SHC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.-", "l": "\"With incorporation of two atoms of oxygen\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016263", "l": "glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17567", "l": "1D-1-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine => myo-inositol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.3", "l": "\"Kynureninase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102770", "l": "inositol phosphorylceramide synthase activity"}, {"i": "MetaCyc:RXN-7795"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29293", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate => (25S)-3-oxocholest-4-en-26-oate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159771", "l": "Furin cleaves pro-protein C to protein C (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389463", "l": "Proteinase-activated receptors can bind thrombin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604722", "l": "Activation of proMMP9 by proteases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5622134", "l": "CRABP1 binds atRA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047296", "l": "homospermidine synthase activity"}, {"i": "EC:2.5.1.44", "l": "\"Homospermidine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37074", "l": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> 2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46714", "l": "H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine => pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55870", "l": "H2O2 + pyruvate => (S)-lactate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875591", "l": "DOCK7 activates RAC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944225", "l": "Association of procollagen type XVII (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5251942", "l": "Hikeshi binds HSP70s:ATP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390438", "l": "FAR2 reduces PalmCoA to HXOL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63583", "l": "20-hydroxyecdysone 22-phosphate + H2O <=> 20-hydroxyecdysone + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38527", "l": "1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21382", "l": "AMP + diphosphate + phytanoyl-CoA => 3,7,11,15-tetramethylhexadecanoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944240", "l": "Association of procollagen type III (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21682", "l": "2-oxophytanate + H2O2 => (2S)-2-hydroxyphytanate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013438", "l": "RHOD binds effectors at the endosome membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662613", "l": "MT3 exchanges zinc for copper (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51594", "l": "benzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + toluene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39877", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a 2,3-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2197690", "l": "Detachment of WASP/WAVE (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-448702", "l": "Caspase-1 active tetramer formation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74059", "l": "PDE6 hydrolyses cGMP to GMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40994", "l": "(E)-4-coumaroyl-CoA + H2O <=> 3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683774", "l": "p-T68-CHEK2 dimerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5666129", "l": "CDC42:GTP recruits DIAPH2-2 to kinetochores (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48746", "l": "(-)-deoxypodophyllotoxin + CO2 + H2O + succinate => (-)-yatein + 2-oxoglutarate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53881", "l": "ADP-alpha-D-glucose + D-glucose 6-phosphate => ADP + alpha,alpha-trehalose 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008597", "l": "calcium-dependent protein serine/threonine phosphatase regulator activity"}, {"i": "REACT:R-HSA-139906", "l": "Activation of BAD by calcineurin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803892", "l": "SFN dimer binds BAX (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16531", "l": "adenosine 5'-phosphosulfate + phosphate => ADP + H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787820", "l": "IL34 dimer binds CSF1R (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64998", "l": "diphosphate + octanoyl-AMP => ATP + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33915", "l": "4-(methylamino)butanoate + H2O + O2 = H2O2 + methylamine + succinate semialdehyde"}, {"i": "EC:1.5.3.21", "l": "\"4-methylaminobutanoate oxidase (methylamine-forming)\""}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0019767", "l": "IgE receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627870", "l": "SLC26A4 does not transport I- from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5662466", "l": "XYLB phosphorylates D-xylulose (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008176", "l": "tRNA (guanine-N7-)-methyltransferase activity"}, {"i": "MetaCyc:TRNA-GUANINE-N7--METHYLTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800794", "l": "PIDD1 associates with CRADD (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51833", "l": "ATP(in) + CoA(in) + H(+)(out) + tetracosanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + tetracosanoyl-CoA(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64845", "l": "(2E)-geraniol + benzoyl-CoA => (2E)-geranyl benzoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66222", "l": "asc-omegaDeltaC7-CoA + H2O2 => asc-omegaC7-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45731", "l": "(E)-caffeyl alcohol + NADP(+) <=> (E)-caffeyl aldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362427", "l": "Hh-Np binds GPC5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53005", "l": "2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate => 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22824", "l": "2'-deoxyuridine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + uracil"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53981", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668023", "l": "TPST1,2 transfer SO4(2-) from PAPS to FVIII (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112430", "l": "Formation of P-TEFb complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102967", "l": "10-hydroxygeraniol oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63421", "l": "2-hydroxyethylphosphonate + CTP => cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218836", "l": "PTK2beta binds alphaVbeta3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.10.-", "l": "\"Protein-tyrosine kinases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177923", "l": "Sustained activation of SRC kinase by SHP2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-425861", "l": "Activation of Protein Kinase C novel isoforms (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102898", "l": "levopimaradienol hydroxylase activity"}, {"i": "MetaCyc:RXN-8517"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044586", "l": "cellotetraose binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60404", "l": "Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) + H2O = Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(2,3-dihydroxybenzoyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31409", "l": "all-trans-4,4'-diapolycopene + FADH2 => all-trans-4,4'-diaponeurosporene + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672948", "l": "MARK3 phosphorylates KSR1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106368", "l": "dTTP dependent (deoxy)nucleoside - phosphate kinase activity"}, {"i": "RHEA:62132", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dTTP = a 2'-deoxyribonucleoside 5'-diphosphate + dTDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63304", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8963915", "l": "1,25(OH)2D binds VDR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28607", "l": "L-valine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-2-methylpropanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008009", "l": "chemokine activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8864569", "l": "WWOX binds TFAP2C (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37356", "l": "H2O + uridine 2'-phosphate => phosphate + uridine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26478", "l": "1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18754", "l": "[protein]-dithiol + NADP(+) => [protein]-disulfide + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54542", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-threonyl-[protein] => H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21647", "l": "ATP + glycerol <=> ADP + H(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202541", "l": "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29357", "l": "2'-deoxyuridine + phosphate => dUMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1006169", "l": "Factor H binds host cell surface markers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12482", "l": "4,5-dioxopentanoate + L-alanine => 5-aminolevulinate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048495", "l": "Roundabout binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21473", "l": "ATP + citrate + CoA => (3S)-citryl-CoA + ADP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851436", "l": "CFHR dimers bind C3b (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6804955", "l": "ATM phosphorylates MDM2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694727", "l": "Endocytosis of protein 3a (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50706", "l": "H(+) + NADH + propanal => 1-propanol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014343", "l": "IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-176956", "l": "Formation of GINS complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31989", "l": "baruol => (S)-2,3-epoxysqualene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052766", "l": "mannoside alpha-1,4-mannosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5629187", "l": "TP53 binds regulatory elements of SESN1,2,3 genes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.8"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033830", "l": "Skp1-protein-hydroxyproline N-acetylglucosaminyltransferase activity"}, {"i": "RHEA:17841", "l": "trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP"}, {"i": "EC:2.4.1.229", "l": "\"[Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653936", "l": "Formation of Ragulator complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32253", "l": "(6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11715", "l": "3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56427", "l": "H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30651", "l": "2 H2O + O2 + urate = allantoin + CO2 + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60452", "l": "2-hydroxyethane-1-sulfonate = acetaldehyde + H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59770", "l": "CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] => hexadecanoyl-CoA + L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9640167", "l": "RRAGA,B exchanges GDP for GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.4.1.-", "l": "\"Forming carbon-carbon bonds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38432", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O => (9Z)-octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45022", "l": "H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine => L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40600", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O => a 2-acyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028724", "l": "AMOT proteins bind YAP1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10218", "l": "ADP + H(+) + phospho-[DNA-directed RNA polymerase] => [DNA-directed RNA polymerase] + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672951", "l": "Inactive RAFs bind YWHAB (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2173323", "l": "Cleavage of C3 by fluid-phase C3i:factor B (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51900", "l": "H2O + N(1)-acetylspermidine = acetate + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41822", "l": "3-oxohexanoyl-[ACP] + CO2 + holo-[ACP] => butanoyl-[ACP] + H(+) + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54369", "l": "acetaldehyde + H(+) + pyruvate => acetoin + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51965", "l": "2-methylpropanenitrile + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2-methylpropanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668545", "l": "NIK autophosphorylates on T559 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23222", "l": "4-chlorobenzoyl-CoA + AMP + diphosphate => 4-chlorobenzoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21988", "l": "malonyl-CoA + pelargonidin 3-O-(6-O-[(E)-caffeoyl]-beta-D-glucoside) 5-O-beta-D-glucoside = 4'''-demalonylsalvianin + CoA"}, {"i": "EC:2.3.1.172", "l": "\"Anthocyanin 5-O-glucoside 6'''-O-malonyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37547", "l": "D-glucose 6-phosphate + NAD(+) = 3-dehydro-D-glucose 6-phosphate + H(+) + NADH"}, {"i": "EC:1.1.1.361", "l": "\"Glucose-6-phosphate 3-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55727", "l": "17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26315", "l": "dihydroxyacetone phosphate + L-aspartate 4-semialdehyde => 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24149", "l": "D-glyceraldehyde 3-phosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (2R)-3-phosphoglycerate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52706", "l": "D-ribose 5-phosphate + uracil => H2O + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55346", "l": "1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-448673", "l": "Formation of caspase-1 p10/p20 dimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210767", "l": "HNF6-dependent synthesis of ONECUT3 protein during early pancreas specification (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77589", "l": "Recognition of AAUAAA sequence by CPSF (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73736", "l": "Acetylation of SL1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020260", "l": "Hydroperoxy reducatse reduces 7(S)-Hp-17(S)-HDHA to RvD5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51483", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209840", "l": "Two DITs combine to form thyroxine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734713", "l": "ORC6 translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57171", "l": "(R)-2-hydroxyglutarate + FAD + H(+) <=> 2-oxoglutarate + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944454", "l": "mTORC1 phosphorylates MAF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22344", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + (E)-caffeoyl-CoA = (R)-rosmarinate + CoA"}, {"i": "EC:2.3.1.140", "l": "\"Rosmarinate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41754", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.48", "l": "\"Ruberlysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668978", "l": "MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700154", "l": "Active ALK binds SHC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8873923", "l": "STARD10 binds LPCAT1 and PC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17899", "l": "(S)-1-phenylethanol + AH2 => A + ethylbenzene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44487", "l": "3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71189", "l": "AFMID hydrolyses NFK to L-KYN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18561", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH"}, {"i": "EC:1.3.1.70", "l": "\"Delta(14)-sterol reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10249", "l": "dUTP + H2O => diphosphate + dUMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029473", "l": "Branching and elongation of mother and daughter filaments (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013974", "l": "Auto-ubiquitination of TRAF3 within activated TLR3 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22710", "l": "a carboxylate + glutathione + H(+) => H2O + S-acylglutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696605", "l": "USP12, USP26 deubiquitinate AR (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376122", "l": "DSCAM/DSCAML1 homodimerization (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43141", "l": "guanosine(26) in tRNA + 2 S-adenosyl-L-methionine => 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189439", "l": "ALAD condenses 2 dALAs to form PBG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8963913", "l": "1,25(OH)2D translocates from cytosol to nucleoplasm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0005172", "l": "vascular endothelial growth factor receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39697", "l": "(R)-3-hydroxy-(13Z)-eicosenoyl-CoA + NADP(+) => 3-oxo-(13Z)-eicosenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374667", "l": "DCC interaction with SIAH2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001095", "l": "TFIIE-class transcription factor complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18962", "l": "D-allose + L-lysyl-[protein] => H2O + N(6)-(D-psicosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64854", "l": "CoA + octyl benzoate => benzoyl-CoA + octan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63052", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209766", "l": "25(OH)D translocates from lysosomal lumen to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102566", "l": "1-acyl dihydroxyacetone phosphate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51550", "l": "(R)-N-methyltetrahydropapaverine + H(+) + S-adenosyl-L-homocysteine => (R)-tetrahydropapaverine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45411", "l": "(2E)-dodecenoyl-CoA + H(+) + NADH <=> dodecanoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60908", "l": "a cytidine in tRNA + S-adenosyl-L-methionine = an N(3)-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430158", "l": "p-SLP-76 binds VAV (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45351", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31033", "l": "beta-D-glucopyranosyl cis-(+)-abscisate + UDP => 2-cis-(+)-abscisate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183072", "l": "EGFR non-clathrin mediated endocytosis (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47183", "l": "(25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+) <=> (25R)-7alpha,26-dihydroxycholest-4-en-3-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196929", "l": "FLAD1 phosphorylates FMN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168166", "l": "NFkB complex is transported from cytosol to nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220979", "l": "NOTCH1 PEST domain mutants stimulate HES1 transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031249", "l": "denatured protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8953111", "l": "E2F6 binds TFDP1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655301", "l": "Activated FGFR2 mutants phosphorylate PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21345", "l": "5-hydroxybenzimidazolylcob(I)amide + H(+) + methanol => Co-methyl-Co-5-hydroxybenzimidazolylcob(III)amide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34538", "l": "H(+) + hexadecanoyl-CoA + L-alanine <=> 1-deoxy-3-dehydrosphinganine + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11823", "l": "diphthamide-[translation elongation factor 2] + NAD(+) <=> H(+) + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659674", "l": "Variant SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45304", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63359", "l": "(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + O2 <=> (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-thiazole-[protein] + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-877281", "l": "PIAS1 binds p-STAT1 dimer (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70241", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050602", "l": "monoprenyl isoflavone epoxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57473", "l": "(E)-4-coumarate + UDP-alpha-D-glucose => 1-O-(trans-4-coumaroyl)-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19836", "l": "(6S)-10-formyltetrahydrofolate + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46630", "l": "androst-5-en-3beta,17beta-diol + NADP(+) => 3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.28"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034336", "l": "misfolded RNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430180", "l": "NCK recruits WASP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37621", "l": "1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55567", "l": "4-hydroxytryptamine + ATP <=> 4-hydoxytryptamine 4-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624132", "l": "UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800793", "l": "PIDD1 translocates to the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36375", "l": "ATP + carbamoyl phosphate + H2O = carbamoyl adenylate + diphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16243", "l": "a ribonucleoside 5'-diphosphate + H(+) + sucrose => an NDP-alpha-D-glucose + D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635845", "l": "GLI proteins bind CDC73 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863463", "l": "STON2 binds SYT proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031751", "l": "D4 dopamine receptor binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015475", "l": "adhesin autotransporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36383", "l": "carbamoyl adenylate + tobramycin = AMP + H(+) + nebramycin 5'"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39335", "l": "3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018766", "l": "RHOU binds effectors at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001063", "l": "glucomannan binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35764", "l": "8-O-methyldihydrosterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => aflatoxin B2 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374899", "l": "Release of noradrenaline  at the synapse (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25567", "l": "H2O + N-acetyl-4-O-acetylneuraminate <=> acetate + H(+) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052844", "l": "inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity"}, {"i": "MetaCyc:RXN-10978"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376145", "l": "SRGAP binds ROBO1:SLIT2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607721", "l": "Activation of NIK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19807", "l": "a purine nucleobase + alpha-D-ribose 1-phosphate => a purine D-ribonucleoside + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60627", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 H2O <=> 2 (9Z)-octadecenoate + 2 H(+) + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983153", "l": "E1 mediated ubiquitin activation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008671", "l": "2-dehydro-3-deoxygalactonokinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507875", "l": "Aquaporins passively transport urea into cells (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46046", "l": "(2E)-octenoyl-CoA => (3Z)-octenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50703", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> calcitriol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008052", "l": "IL1F10(?-152) binds IL1RAPL1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64282", "l": "acetophenone + L-alanine => (S)-1-phenylethylamine + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65883", "l": "1-hydroxy-5alpha-androstan-3,17-dione + A <=> 5alpha-androstan-1,3,17-trione + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37055", "l": "3-(4-hydroxyphenyl)pyruvate + dimethylallyl diphosphate = 3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate"}, {"i": "EC:2.5.1.111", "l": "\"4-hydroxyphenylpyruvate 3-dimethylallyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13235", "l": "alpha-D-ribose 1-phosphate + guanine => guanosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42845", "l": "6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH => 7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59274", "l": "D-cysteine => L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43138", "l": "4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine => guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35077", "l": "doxorubicin(out) + H(+)(in) => doxorubicin(in) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44627", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP(+) <=> dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47900", "l": "ganglioside GM3 (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57148", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43908", "l": "beta-D-galactosyl-(1<->1)-sphing-4-enine + H2O = D-galactose + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433967", "l": "Dimerized Phospho-IRF3 is Transported To The Nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23326", "l": "ADP-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide => 2'-phospho-[ligated tRNA] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030370", "l": "intercellular adhesion molecule-3 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49807", "l": "2-methylpropan-1-amine + FMNH2 + O2 <=> FMN + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19906", "l": "NAD(+) + spermidine => dehydrospermidine + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39714", "l": "O2 + 2 reduced coenzyme F420-(gamma-Glu)(n) <=> 2 H(+) + 2 H2O + 2 oxidized coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29341", "l": "(S)-malate(out) + 2 H(+)(out) => (S)-malate(in) + 2 H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27703", "l": "aldehydo-D-galacturonate => keto-D-tagaturonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65530", "l": "CoA + hexyl octanoate => hexan-1-ol + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9714483", "l": "RAC2 translocates to the ER membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66806", "l": "4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + pisiferate => ferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047114", "l": "kynurenate-7,8-dihydrodiol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730840", "l": "Activation of RAC1 by VAV (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34061", "l": "didehydroagroclavine + H(+) + NADPH => agroclavine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-947514", "l": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44837", "l": "globoside NORint (d18:1(4E)) + UDP-alpha-D-galactose => globoside NOR2 (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54931", "l": "3-oxo-(9Z)-hexadecenoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64249", "l": "decanoyl-CoA + glycine => CoA + H(+) + N-decanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3229181", "l": "CALM1:Ca2+ binds CNG channel (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5096537", "l": "Defective GALNT3 does not transfer GalNAc to mucins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0016917", "l": "GABA receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18672", "l": "adenosine + H2O <=> adenine + D-ribose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072354", "l": "histone kinase activity (H3-T3 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5676229", "l": "WIPIs bind PI3P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018475", "l": "trans-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29768", "l": "ATP + D-methionine(out) + H2O => ADP + D-methionine(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53651", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-corvol ether A + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41459", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45828", "l": "(3R)-hydroxyhexanoyl-CoA + NAD(+) = 3-oxohexanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29266", "l": "L-leucine(in) + Na(+)(in) <=> L-leucine(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3266566", "l": "G6PC2 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (islet) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161789", "l": "15S-HETE is oxidised to 15-oxoETE by 15-HEDH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047578", "l": "4-hydroxyglutamate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047608", "l": "acetylindoxyl oxidase activity"}, {"i": "RHEA:16941", "l": "N-acetylindoxyl + O2 = H2O + N-acetylisatin"}, {"i": "EC:1.7.3.2", "l": "\"Acetylindoxyl oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55261", "l": "2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45515", "l": "[C-phycocyanin beta-subunit]-Cys(155)-phycocyanobilin <=> (2R,3E)-phycocyanobilin + apo-[C-phycocyanin beta-subunit]-Cys(155)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48469", "l": "ganglioside GM1b (d18:1(4E)) + H2O => ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24487", "l": "NAD(+) + sulcatol <=> H(+) + NADH + sulcatone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60832", "l": "a 5'-end triphospho-guanosine in mRNA + H2O = a 5'-end diphospho-guanosine in mRNA + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40538", "l": "4 H(+) + narbomycin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + novapikromycin + 4 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909724", "l": "Recruitment of IFNAR1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64231", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2032770", "l": "Translocation of YAP1 to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928591", "l": "EPH:EFN tetramers oligomerise (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66420", "l": "ATP + glutathione(in) + H2O + tauroursodeoxycholate(in) = ADP + glutathione(out) + H(+) + phosphate + tauroursodeoxycholate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45008", "l": "H2O + N-(octadecanoyl)-sphinganine = octadecanoate + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55126", "l": "5-methylhexanoyl-[ACP] + NAD(+) => (2E)-5-methylhexenoyl-[ACP] + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10553", "l": "D-glucose + O2 => 2-dehydro-D-glucose + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852331", "l": "GTSE1 translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59317", "l": "D-cellobiose + O2 => D-cellobiono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0031409", "l": "pigment binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3640862", "l": "Tankyrase binds AXIN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39955", "l": "(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60912", "l": "cytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-methionine = H(+) + N(3)-methylcytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483087", "l": "PI is exchanged with PC by PITPNB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23045", "l": "H(+) + N,N-dihydroxy-L-tyrosine => (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40623", "l": "H2O + tritetradecanoylglycerol = 2,3-ditetradecanoyl-sn-glycerol + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785126", "l": "FA core complex assembles at DNA interstrand crosslinks (ICLs) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53043", "l": "4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 17beta-estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376419", "l": "Formation of NR-MED1 Coactivator Complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175976", "l": "TMT transfers CH3 from AdoMet to BME (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.3.-", "l": "\"With oxygen as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2176452", "l": "Degradation of ubiquitinated SMAD2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65695", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine <=> a diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23666", "l": "a 2-oxocarboxylate + AH2 => A + a (2R)-2-hydroxycarboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15537", "l": "(R)-3-sulfolactate + NADP(+) = 3-sulfopyruvate + H(+) + NADPH"}, {"i": "EC:1.1.1.338", "l": "\"(2R)-3-sulfolactate dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004334", "l": "fumarylacetoacetase activity"}, {"i": "RHEA:10244", "l": "4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)"}, {"i": "EC:3.7.1.2", "l": "\"Fumarylacetoacetase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57028", "l": "FADH2 + N-methylnicotinate + O2 = (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2328037", "l": "Fibrillin-1 binds integrins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64025", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8),N'(8)-citryl-bis(spermidine) => H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000103", "l": "CUBN:AMN binds CBLIF:Cbl (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340214", "l": "CYGB binds O2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30805", "l": "4-aminobutanoate + 2 H(+) + NADPH => 4-aminobutanal + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5618107", "l": "ATP binding to HSP90 triggers conformation change (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033870", "l": "thiol sulfotransferase activity"}, {"i": "RHEA:14637", "l": "3'-phosphoadenylyl sulfate + a thiol = adenosine 3',5'-bisphosphate + H(+) + S-alkyl thiosulfate"}, {"i": "EC:2.8.2.16", "l": "\"Thiol sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18293", "l": "ATP + CoA + oxalate = AMP + diphosphate + oxalyl-CoA"}, {"i": "EC:6.2.1.8", "l": "\"Oxalate--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017166", "l": "vinculin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627107", "l": "XIAP binds CASP7 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50136", "l": "ethyl (9Z)-octadecenoate + H2O = (9Z)-octadecenoate + ethanol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42758", "l": "5-methylcytidine(1407) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1407) in 16S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13371", "l": "diphosphate + isoprene => dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30238", "l": "H2O + L-glutamate 5-semialdehyde + NAD(+) <=> 2 H(+) + L-glutamate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63555", "l": "angiotensin-(1-7) + H2O <=> angiotensin-(1-5) + L-histidyl-L-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16688", "l": "di-trans,poly-cis-dolichol + hexadecanoyl-CoA <=> CoA + dolichyl hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13817", "l": "[protein]-disulfide + H2O + phylloquinone = 2,3-epoxyphylloquinone + [protein]-dithiol"}, {"i": "RHEA:57744", "l": "[protein]-disulfide + phylloquinol = [protein]-dithiol + phylloquinone"}, {"i": "EC:1.17.4.4", "l": "\"Vitamin-K-epoxide reductase (warfarin-sensitive)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.7", "l": "\"Aldehyde dehydrogenase (FAD-independent)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389762", "l": "Phosphorylation of PD-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449718", "l": "Addition of a third mannose to the N-glycan precursor by ALG2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52470", "l": "16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17beta-estriol + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035460", "l": "L-ascorbate 6-phosphate lactonase activity"}, {"i": "RHEA:28803", "l": "H2O + L-ascorbate 6-phosphate = 3-dehydro-L-gulonate 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624494", "l": "RAF1 binds p21 RAS:GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11924", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = globoside Gb3Cer (d18:1(4E)) + H(+) + UDP"}, {"i": "EC:2.4.1.228", "l": "\"Lactosylceramide 4-alpha-galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425861", "l": "Activation of Protein Kinase C novel isoforms (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54273", "l": "2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2 => (3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11776", "l": "2 H(+) + O2 + octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin] = (9Z)-octadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.19.2", "l": "\"Stearoyl-[acyl-carrier-protein] 9-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28481", "l": "galactarate(in) <=> galactarate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31019", "l": "4 AH2 + all-trans-4,4'-diapolycopene + 4 O2 = 4 A + all-trans-4,4'-diapolycopene-4,4'-dial + 6 H2O"}, {"i": "EC:1.14.99.44", "l": "\"Diapolycopene oxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983158", "l": "Trimming of peptides in ER (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909721", "l": "Translocation of ISGF3 complex to nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55285", "l": "all-trans-retinol + tetradecanoyl-CoA => all-trans-retinyl tetradecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788571", "l": "STAT1,STAT3,STAT6 bind IL13:IL13R type II (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193705", "l": "IKKbeta phosphorylates IkB causing NF-kB to dissociate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49933", "l": "(3E,5Z)-octadienoyl-CoA => (2E,5Z)-octadienoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211164", "l": "AKT phosphorylates FOXO1A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696358", "l": "TREM,CD300 binds lipids (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66765", "l": "ATP + folate(in) + H2O => ADP + folate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606288", "l": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875816", "l": "STAT3 binds activated MET receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120243", "l": "2-iminopropanoate deaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29689", "l": "alpha-D-glucose 1-phosphate + alpha-maltohexaose => alpha-maltoheptaose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40399", "l": "1,2-dihydro-beta-NADP + H(+) + O2 = H2O2 + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189488", "l": "UROS transforms HMB to URO3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047725", "l": "inulosucrase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54880", "l": "(4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one = (3R)-3-isopropenyl-6-oxoheptanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690873", "l": "ACO1 binds 4Fe-4S (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53367", "l": "5,6-dihydrouridine(47) in tRNA + NAD(+) <=> H(+) + NADH + uridine(47) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.2.7", "l": "\"Methanol dehydrogenase (cytochrome c)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39552", "l": "(2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH => (21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5225649", "l": "RBBP7 binds histone H3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21085", "l": "chondroitin 4'-sulfate => dermatan 4'-sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362427", "l": "Hh-Np binds GPC5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50880", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-glycerol = 4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)"}, {"i": "EC:2.7.8.45", "l": "\"Teichoic acid glycerol-phosphate transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191656", "l": "Closure of gap junction (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58378", "l": "decanal + H(+) + NADPH => decan-1-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13304", "l": "a 1,2-diacyl-sn-glycerol + a sterol <=> a 1-acyl-sn-glycerol + a sterol ester"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046941", "l": "azetidine-2-carboxylic acid acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56124", "l": "A + all-trans-lycopene + dimethylallyl diphosphate + H2O = AH2 + diphosphate + nonaflavuxanthin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66381", "l": "ATP + glutathione(in) + glycodeoxycholate(in) + H2O => ADP + glutathione(out) + glycodeoxycholate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030899", "l": "calcium-dependent ATPase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710263", "l": "GZMB cleaves GSDME (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109857", "l": "MAP2K1 binds MAPK3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120298", "l": "peptide noradrenalinyltransferase activity"}, {"i": "RHEA:66560", "l": "(R)-noradrenaline + L-glutaminyl-[protein] = 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35366", "l": "(2E)-13-methyltetradecenoyl-CoA + H(+) + NADPH <=> isopentadecanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5684096", "l": "CDK2 phosphorylates RBBP8 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35500", "l": "11-oxo-beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => glycyrrhetinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65979", "l": "cholesta-5,7-dien-3beta-ol + hnu <=> previtamin D3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57402", "l": "acetate + H(+) + narcotine hemiacetal => 3-O-acetylpapaveroxine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64214", "l": "a fatty acid + L-isoleucine => an N-(fatty acyl)-L-isoleucine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209536", "l": "IkB is ubiquitinated and degraded (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333609", "l": "MeSebGalNac is hydrolysed to MeSeH and bGalNac (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16034", "l": "2-oxoglutarate + gibberellin A44 + O2 => CO2 + gibberellin A19 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.26", "l": "\"Pseudolysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-984606", "l": "Kinesin-5 is a homotetramer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28355", "l": "decanoyl-CoA + FAD + H(+) => (2E)-decenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1370500", "l": "PRLR binds SCF beta-TrCP complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869694", "l": "oxPL binds CD14 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19015", "l": "dTDP + H(+) + phosphate => dTTP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25054", "l": "(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 = (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018758", "l": "RHOH binds effectors at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9648017", "l": "EML4 binds to microtubules (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32030", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-alpha-cuprenene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050641", "l": "6-methylsalicylic acid synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050213", "l": "progesterone 5-alpha-reductase activity"}, {"i": "RHEA:21952", "l": "5alpha-pregnane-3,20-dione + NADP(+) = H(+) + NADPH + progesterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036463", "l": "TRAIL receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12157", "l": "2-glutathionyl-2-methylbut-3-en-1-ol + H2O + 2 NAD(+) => 2-glutathionyl-2-methylbut-3-enoate + 3 H(+) + 2 NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53583", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40486", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22651", "l": "holo-[cytochrome c] <=> apo-[cytochrome c] + heme b"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047315", "l": "kynurenine-glyoxylate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035380", "l": "very long-chain-3-hydroxyacyl-CoA dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0019966", "l": "interleukin-1 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32133", "l": "butanoyl-CoA + CO2 => (2S)-ethylmalonyl-CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42171", "l": "20alpha-hydroxy-5beta-pregnan-3-one + NADP(+) <=> 5beta-pregnan-3,20-dione + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49789", "l": "chenodeoxycholoyl-CoA + glycine => CoA + glycochenodeoxycholate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40789", "l": "CoA + H(+) + tetracosanoate => H2O + tetracosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430183", "l": "NCK binds PAK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15640", "l": "[alginate](n) + GDP-alpha-D-mannuronate <=> [alginate](n+1) + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692131", "l": "SOX9 binds the FGF9 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47864", "l": "1,2,3-trioctanoylglycerol + H2O = dioctanoylglycerol + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45570", "l": "[acharan](n) => [heparosan](n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32167", "l": "ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine = aerobactin + AMP + diphosphate + H(+)"}, {"i": "EC:6.3.2.39", "l": "\"Aerobactin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20686", "l": "galactitol + NAD(+) => H(+) + keto-D-tagatose + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48880", "l": "a quinone + CO + H2O = a quinol + CO2"}, {"i": "EC:1.2.5.3", "l": "\"Aerobic carbon monoxide dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56672", "l": "dihydro-4-coumaroyl-CoA + NADP(+) = (E)-4-coumaroyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2301205", "l": "SETD8 monomethylates histone H4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.33"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17410", "l": "(S)-coclaurine + S-adenosyl-L-methionine => (S)-N-methylcoclaurine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621410", "l": "HMGCR gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210300", "l": "Interaction of DAP12 and TREM2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451311", "l": "Activation of Ca-permeable Kainate receptors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952069", "l": "HDAC4 deacetylates RUNX3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50911", "l": "a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 <=> A + a 3-demethylubiquinol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26207", "l": "4-nitrocatechol + H2O + NADP(+) => 4-nitrophenol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32694", "l": "(2E)-geranyl diphosphate <=> (E)-beta-ocimene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730862", "l": "Autophosphorylation of LYN kinase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18633", "l": "2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate"}, {"i": "EC:6.3.5.5", "l": "\"Carbamoyl-phosphate synthase (glutamine-hydrolyzing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51535", "l": "H(+) + NADPH + O2 + urate <=> 5-hydroxyisourate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35470", "l": "(6S)-5,6,7,8-tetrahydrofolate + S,S-dimethyl-beta-propiothetin <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-(methylsulfanyl)propanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39213", "l": "(2E)-hexacosenoyl-CoA + H2O => (3R)-hydroxyhexacosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664940", "l": "PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008043", "l": "MAPK8 phosphorylation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47679", "l": "ATP + N-acetyl-D-galactosamine <=> ADP + H(+) + N-acetyl-D-galactosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211983", "l": "CYP2J2 oxidises ARA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674140", "l": "PAQR3 binds inactive RAFs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53189", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine + H2O => 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29819", "l": "ATP + H2O + L-isoleucine(out) = ADP + H(+) + L-isoleucine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140769", "l": "factor VII -> factor VIIa (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23039", "l": "2 inosine + O2 <=> 2 5'-dehydroinosine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72160", "l": "Cleavage at the 3'-Splice Site and Exon Ligation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43913", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043994", "l": "histone acetyltransferase activity (H3-K23 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16986", "l": "3-oxoadipate + NADP(+) => H(+) + maleylacetate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74258", "l": "XDH oxidizes xanthine to form urate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090612", "l": "cAMP deaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67073", "l": "a very long-chain fatty acyl-CoA + H2O => a very long-chain fatty acid + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102491", "l": "dGTP phosphohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13752", "l": "a ribonucleoside 5'-triphosphate + AMP <=> a ribonucleoside 5'-diphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41465", "l": "ent-sandaracopimara-8(14),15-diene + O2 + reduced [NADPH--hemoprotein reductase] => ent-sandaracopimaradien-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20688", "l": "galactitol + NAD(+) <=> H(+) + keto-D-tagatose + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047834", "l": "D-threo-aldose 1-dehydrogenase activity"}, {"i": "RHEA:19645", "l": "a D-threo-aldose + NAD(+) = a D-threo-aldono-1,5-lactone + H(+) + NADH"}, {"i": "EC:1.1.1.122", "l": "\"D-threo-aldose 1-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174119", "l": "Free APC/C phosphorylated by Plk1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689000", "l": "AADAC deacetylates PHEN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19710", "l": "a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17836", "l": "3-hydroxyanthranilate + S-adenosyl-L-methionine <=> 3-hydroxy-4-methylanthranilate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56295", "l": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] <=> 4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28630", "l": "O2 + reduced [NADPH--hemoprotein reductase] + solavetivol <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + solavetivone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130706", "l": "MHC class II antigen processing (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20279", "l": "an N-acetoxyarylamine + CoA => acetyl-CoA + an N-hydroxyarylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48769", "l": "ATP + D-erythrulose => ADP + D-erythrulose 4-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56616", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene = 1,2,4-trichlorobenzene + chloride + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25339", "l": "H(+) + urea => isocyanate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45552", "l": "H2O + N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-tetradecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58146", "l": "AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met) => acetate + ATP + cytidine(34) in elongator tRNA(Met)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.34"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420980", "l": "Activation of Ca permeable AMPA receptors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59795", "l": "H2O + NADP(+) + yersinopine <=> (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29171", "l": "a ubiquinol + 2 O2 = a ubiquinone + 2 H(+) + 2 superoxide"}, {"i": "EC:1.10.3.17", "l": "\"Superoxide oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38943", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-350769", "l": "trans-Golgi Network Coat Activation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047692", "l": "ATP deaminase activity"}, {"i": "MetaCyc:ATP-DEAMINASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39899", "l": "7-deoxyloganetin + UDP-alpha-D-glucose = 7-deoxyloganin + H(+) + UDP"}, {"i": "EC:2.4.1.324", "l": "\"7-deoxyloganetin glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13664", "l": "H2O + N-formimidoyl-L-aspartate <=> N-formyl-L-aspartate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-744887", "l": "Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46188", "l": "an aliphatic nitrile + 2 H2O = a carboxylate + NH4(+)"}, {"i": "EC:3.5.5.7", "l": "\"Aliphatic nitrilase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63056", "l": "acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine = 5-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-555065", "l": "Formation of clathrin coated vesicle (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20949", "l": "3-sulfopyruvate + H(+) => CO2 + sulfoacetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785126", "l": "FA core complex assembles at DNA interstrand crosslinks (ICLs) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60840", "l": "a 5'-end diphospho-adenosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] = a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26443", "l": "a ubiquinone + ethanol => a ubiquinol + acetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-532603", "l": "Nephrin mediated activation of N-WASP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11486", "l": "2 [Fe(II)cytochrome c](out) + a quinone + 2 H(+)(out) => 2 [Fe(III)cytochrome c](out) + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37870", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA <=> 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63130", "l": "docosanoate + ethanolamine => H2O + N-docosanoyl-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28061", "l": "L-lyxose <=> L-xylulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12999", "l": "2-O-[(E)-feruloyl]-D-galactarate + CoA => (E)-feruloyl-CoA + galactarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31835", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-3-dehydro-6-deoxy-alpha-D-galactose"}, {"i": "EC:5.3.2.3", "l": "\"TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693198", "l": "RHOD binds effectors at the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24243", "l": "A + AMP + 2 H(+) + sulfite <=> adenosine 5'-phosphosulfate + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33434", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate <=> (3E)-2-oxohex-3-enedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36107", "l": "gibberellin A4 + S-adenosyl-L-methionine = O-methyl gibberellin A4 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22482", "l": "4-nitroquinoline N-oxide + 2 H(+) + 2 NADH => 4-(hydroxyamino)quinoline N-oxide + H2O + 2 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70272", "l": "PGM:Mg2+ isomerise G6P to G1P (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9670014", "l": "Factor VIIIa dissociates  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15595", "l": "amicoumacin A + phosphate => amicoumacin A 2-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5099899", "l": "WNT5A binds FZD4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44766", "l": "6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-decaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43704", "l": "ATP + H(+) + tetradecanoate = diphosphate + tetradecanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72621", "l": "Ribosomal scanning  (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678925", "l": "NR3C1 binds NR3C1 agonists (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036283", "l": "Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the terminal GlcA residue (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46941", "l": "AMP + diphosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] => ATP + holo-[LYS2 peptidyl-carrier protein] + L-2-aminoadipate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800298", "l": "HGF dimer binds MET (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34386", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + UDP-alpha-D-galactofuranose <=> beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60291", "l": "N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14225", "l": "6-hydroxyhexanoate + NAD(+) = 6-oxohexanoate + H(+) + NADH"}, {"i": "EC:1.1.1.258", "l": "\"6-hydroxyhexanoate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306876", "l": "NLRP3 activation by small molecules (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730862", "l": "Autophosphorylation of LYN kinase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035496", "l": "lipopolysaccharide-1,5-galactosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755524", "l": "SUMOylation of NR1I2 with SUMO3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27619", "l": "(2Z,6E)-farnesyl diphosphate + 11 isopentenyl diphosphate => di-trans,undeca-cis-tetradecaprenyl diphosphate + 11 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54856", "l": "H(+) + NADPH + O2 + octan-3-one = ethyl hexanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47628", "l": "glyoxylate + H2O + propanoyl-CoA = 3-methylmalate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013004", "l": "RHOA binds effectors at the ER membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62358", "l": "8-oxo-GMP + H(+) + phosphate => 8-oxo-GDP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30172", "l": "hexadecanoyl-[ACP] + sn-glycerol 3-phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168310", "l": "Release of the RNP into the host cell nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30460", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol => (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + acetone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34395", "l": "L-phenylalanine = L-beta-phenylalanine"}, {"i": "EC:5.4.3.10", "l": "\"Phenylalanine aminomutase (L-beta-phenylalanine forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40109", "l": "1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12930", "l": "2-oxoglutarate + acetyl-CoA + H2O => (2R)-homocitrate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31870", "l": "(S)-2,3-epoxysqualene <=> baccharis oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44324", "l": "1-butyrylglycerol + H2O = butanoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937792", "l": "RUNX3 binds SRC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14393", "l": "N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine = 3 H(+) + N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.301", "l": "\"Cypemycin N-terminal methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018549", "l": "methanethiol oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10101", "l": "a sterol ester + H2O => a fatty acid + a sterol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61958", "l": "1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 [Fe(III)-cytochrome b5] + 2 H2O => 1-O-octadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211206", "l": "Translocation of DFF to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52761", "l": "(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O => (Z)-1-(glycyl-L-cystein-S-yl)-2-phenylacetohydroximate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20601", "l": "formaldehyde + mycothiol + NAD(+) = H(+) + NADH + S-formylmycothiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57071", "l": "3-oxoisoapionate + ATP <=> 3-oxoisoapionate 4-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853429", "l": "PHLDA1 binds AURKA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5159250", "l": "ATF7IP binds SETDB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6804741", "l": "MDM2 forms homo- or heterodimers (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38426", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24390", "l": "alpha-D-ribose 1-phosphate + uracil => phosphate + uridine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58565", "l": "15alpha-stemmadenine + NADP(+) => 15alpha-stemmadenine intermediate II + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47169", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+) => 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27609", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35035", "l": "4-aminobutanoate(in) = 4-aminobutanoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64319", "l": "2 dihydrogeodin + 2 H(+) + O2 <=> 2 (+)-geodin + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2197770", "l": "STAB1 (FEEL-1) binds ligands (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909729", "l": "Activation of JAK kinases (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48975", "l": "ATP + H2O + phosphite(out) <=> ADP + H(+) + phosphate + phosphite(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30783", "l": "D-glyceraldehyde + H2O + NAD(+) = (R)-glycerate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-981728", "l": "Factor H binds to membrane-associated C3b (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40420", "l": "H2O + phytanoyl-CoA => 3,7,11,15-tetramethylhexadecanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49754", "l": "CO2 + 2 H2O + NAD(+) + proviolacein => 2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070774", "l": "phytoceramidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190682", "l": "Connexin synthesis (generic) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41384", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734687", "l": "ORC6 is phosphorylated on T195 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39577", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+) => 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56429", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53354", "l": "H(+) + NADH + uridine(20b) in tRNA => 5,6-dihydrouridine(20b) in tRNA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38731", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14144", "l": "AMP + glutathione disulfide + 2 H(+) + sulfite <=> adenosine 5'-phosphosulfate + 2 glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507719", "l": "p62:MEKK3 binds to TRAF6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38705", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58656", "l": "a 5'-(5'-phospho)-ribonucleoside-RNA + S-adenosyl-L-methionine = a 5'-(5'-phosphomethyl)-ribonucleoside-RNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004802", "l": "transketolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163320", "l": "Association of mTERF with the termination sequence (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.33", "l": "\"Amylo-alpha-1,6-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51951", "l": "(2S)-2-methylbutanenitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2-methylbutanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448660", "l": "IL31:IL31RA:JAK1 binds OSMR:JAK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443418", "l": "GP1b signaling involves c-Src (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44924", "l": "2-oxoadipate + acetyl-CoA + H2O = (R)-dihomocitrate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34123", "l": "3,5,7-trioxododecanoyl-CoA = CoA + H(+) + olivetolate"}, {"i": "EC:4.4.1.26", "l": "\"Olivetolic acid cyclase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4837364", "l": "Secretion of SOD3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39521", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+) => 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36069", "l": "Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine => Co-precorrin-6B + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20291", "l": "acetate + CoA + H(+) => acetyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852010", "l": "BTNL2 binds activated T cells surface (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57239", "l": "GMP + methylglyoxal <=> N(2)-(1-hydroxy-2-oxopropyl)-GMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202137", "l": "AKT1 binds eNOS complex via HSP90 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29541", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030781", "l": "6-O-methylnorlaudanosoline 5'-O-methyltransferase activity"}, {"i": "MetaCyc:2.1.1.121-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29222", "l": "a menaquinone + sn-glycerol 3-phosphate <=> a menaquinol + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218891", "l": "RIPK1:RIPK3 oligomer binds MLKL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654425", "l": "Activated FGFR4 binds SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1980125", "l": "ITCH binds DTX (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59178", "l": "AMP + H(+) + O-phospho-L-serine => ADP + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1606564", "l": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.68", "l": "\"Tentoxilysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55252", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine = 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65775", "l": "2 H(+) + isoproturon + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1-methyl-3-[4-(propan-2-yl)phenyl]urea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64557", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one => 8-epi-ilicicolin H"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050682", "l": "AF-2 domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21736", "l": "(3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604763", "l": "Autocatalytic activation of MMP7 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668558", "l": "NBEA binds PRKAR2A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25101", "l": "ATP + UDP <=> ADP + UTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877338", "l": "RUNX1 and NFATC2 bind the IL2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36954", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + heptadecanoyl-CoA + O2 <=> (9Z)-heptadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730882", "l": "Phosphorylation of PKC-theta (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483087", "l": "PI is exchanged with PC by PITPNB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166753", "l": "Conversion of C4 into C4a and C4b (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614933", "l": "ACEIs bind ACE (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0001873", "l": "polysaccharide immune receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21245", "l": "an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine => an 8-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799431", "l": "TP53 binds HIPK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63205", "l": "H2O + octadecanoyl-[ACP] => H(+) + holo-[ACP] + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031832", "l": "type 6 serotonin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66705", "l": "H2O + mycophenolyl-CoA => CoA + H(+) + mycophenolate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-606326", "l": "HJURP:CENPA complex localizes to the centromere (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59019", "l": "4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + NAD(+) <=> CO2 + cycloeucalenone + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54327", "l": "a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 8 oxidized 2[4Fe-4S]-[ferredoxin] <=> a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46009", "l": "CoA + NAD(+) + pentanal => H(+) + NADH + pentanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354173", "l": "Activation of Rap1 by cytosolic GEFs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670436", "l": "p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63750", "l": "UDP + zolarsartan-2-N-beta-D-glucuronide => UDP-alpha-D-glucuronate + zolasartan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36652", "l": "8-desmethylnovobiocic acid + S-adenosyl-L-methionine => H(+) + novobiocic acid + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.59", "l": "\"Mitochondrial intermediate peptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373711", "l": "DCC interaction with Netrin-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420083", "l": "PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "56.150635229200589", "identifiers": [{"i": "GO:0060089", "l": "molecular transducer activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8986258", "l": "SLIT2:ROBO1 binds CXCR4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25434", "l": "beta-D-ribofuranose => beta-D-ribopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70592", "l": "PXLP-K259-GOT1 dimer deaminates L-Asp (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008036", "l": "RUNX2 binds to HIVEP3 and WWP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465924", "l": "OPN1LW binds 11cRAL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47142", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (9Z,12Z)-octadecadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46827", "l": "4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41156", "l": "1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-8E-octadecenoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.99.-.-", "l": "\"Other isomerases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685011", "l": "ATR activation at DNA DSBs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222417", "l": "TrxA reactivates AhpC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32684", "l": "5-hydroxymethylfurfural + 2 H2O + 3 O2 => 2,5-dicarboxyfuran + 2 H(+) + 3 H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29474", "l": "D-ribose 5-phosphate + H2O <=> D-ribose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350598", "l": "Arginine<=>Agmatine+CO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71783", "l": "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018754", "l": "GDIs bind RHOH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47620", "l": "2-ethylhexyl sulfate + 2-oxoglutarate + O2 = 2-ethylhexanal + CO2 + H(+) + succinate + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008822", "l": "PPM1D dephosphorylates RUNX2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13309", "l": "H2O + NAD(+) + vanillin = 4-hydroxy-3-methoxybenzoate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.67", "l": "\"Vanillin dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28414", "l": "gamma-L-glutamylputrescine + H2O + O2 = 4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19938", "l": "glycine + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + sarcosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37512", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247843", "l": "secretion of WNT ligands (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663785", "l": "CHRNA9:CHRNA10:AcCho transports Ca2+ from the extracellular region to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45412", "l": "H2O + prostaglandin D2-1-glycerol ester = glycerol + H(+) + prostaglandin D2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72095", "l": "Internal Methylation of mRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654425", "l": "Activated FGFR4 binds SHC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450533", "l": "PKCdelta phosphorylates HuR (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102780", "l": "sitosterol hydroxylase activity"}, {"i": "MetaCyc:RXN-7876"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357432", "l": "AXL binds SRC-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008805", "l": "carbon-monoxide oxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9749197", "l": "ORC1 binds to H4K20me2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34209", "l": "beta-D-glucose 1-phosphate + L-rhamnopyranose => 3-O-alpha-D-glucosyl-L-rhamnose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16773", "l": "ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose = ganglioside GM1 (d18:1(4E)) + H(+) + UDP"}, {"i": "EC:2.4.1.62", "l": "\"Ganglioside galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975040", "l": "KRAB-ZNF / KAP Interaction (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13996", "l": "(S)-3-amino-2-methylpropanoate + 2-oxoglutarate <=> 2-methyl-3-oxopropanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709885", "l": "BIL scavenges NO (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51438", "l": "(2R)-2-amino-4-oxopentanoate + CoA => acetyl-CoA + D-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653886", "l": "B4GALT1 binds LALBA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008873", "l": "gluconate 2-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23145", "l": "H2O + N-acetyl-alpha-D-glucosamine + NAD(+) => 2 H(+) + N-acetyl-D-glucosaminate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0016737", "l": "oxidoreductase activity, acting on reduced flavodoxin as donor"}, {"i": "EC:1.19.-.-", "l": "\"Acting on reduced flavodoxin as donor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696358", "l": "TREM,CD300 binds lipids (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37036", "l": "H2O + L-2-aminopentanoate + NAD(+) => 2-oxopentanoate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39026", "l": "an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212658", "l": "Tranport of L-Glutamate (mitochondrial matrix) to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218805", "l": "PKC autophosphorylates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0008559", "l": "ABC-type xenobiotic transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56131", "l": "A + dimethylallyl diphosphate + H2O + nonaflavuxanthin <=> AH2 + diphosphate + flavuxanthin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097003", "l": "adipokinetic hormone receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31665", "l": "L-glutamate + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose => 2-oxoglutarate + UDP-N-acetylbacillosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38188", "l": "19-oxotestosterone + O2 + reduced [NADPH--hemoprotein reductase] => 17beta-estradiol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222006", "l": "STK11 (LKB1) phosphorylates NUAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48752", "l": "2-oxoglutarate + O2 + validamycin A = CO2 + H(+) + succinate + validamycin B"}, {"i": "EC:1.14.11.52", "l": "\"Validamycin A dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805285", "l": "PLK3 phosphorylates TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694082", "l": "XK:KEL:Zn2+ cleaves EDN3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39880", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol => a 1-acyl-sn-glycero-3-phosphoethanolamine + a 2,3-diacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097020", "l": "COPII receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2396009", "l": "STING binds c-di-GMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213239", "l": "Formation of MHC II alpha beta heterodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-164832", "l": "ATPase synthesizes ATP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014467", "l": "RHOG binds effectors at the ER membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35803", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 2'-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694662", "l": "Protein 3a forms a homotetramer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047044", "l": "androstan-3-alpha,17-beta-diol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622386", "l": "LEF1 binds the promoter of the CEBPA gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43877", "l": "3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oate + ATP + CoA => 3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19506", "l": "indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose => (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54358", "l": "2-methylpropanal + CO2 => 3-methyl-2-oxobutanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58775", "l": "1-O-hexadecyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-O-hexadecyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11024", "l": "ATP + NH4(+) = ADP + 2 H(+) + phosphoramidate"}, {"i": "EC:2.7.3.8", "l": "\"Ammonia kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710353", "l": "GSDMD (1-275) binds cardiolipin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419049", "l": "ROCK activation by RHO (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004436", "l": "phosphatidylinositol diacylglycerol-lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37602", "l": "(9Z,12Z)-hexadecadienoyl-CoA + AH2 + O2 <=> (9Z,12Z,15Z)-hexadecatrienoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46125", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10072", "l": "N,N-dimethylglycine + S-adenosyl-L-methionine = glycine betaine + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.161", "l": "\"Dimethylglycine N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33497", "l": "3-heptaprenyl-sn-glycero-1-phosphate + diphosphate => all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653957", "l": "Rag dimer formation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12194", "l": "(+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "80.661393760018115", "identifiers": [{"i": "GO:0016894", "l": "endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters"}, {"i": "EC:3.1.31.-", "l": "\"Endoribonucleases active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6795290", "l": "TORC2 complex phosphorylates SGK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951500", "l": "Dissociation of CANX from nonameric complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24566", "l": "a 3-oxoacyl-CoA + succinate => a 3-oxo acid + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32517", "l": "(3S,6R)-6-hydroxy-3-isopropenylheptanoate + H(+) => (4S,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52641", "l": "(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + octanoyl-CoA => (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33358", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA <=> 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349426", "l": "Phosphorylation of MDM4 by CHEK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53297", "l": "(2E)-decenoyl-CoA + NADP(+) => (2E,4E)-decadienoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001626", "l": "nociceptin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785165", "l": "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086410", "l": "CDK1 phosphorylates BORA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31323", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP-alpha-D-mannose = (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + GDP + H(+)"}, {"i": "EC:2.4.1.270", "l": "\"Mannosylglucosyl-3-phosphoglycerate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27858", "l": "2',3'-cyclic GMP + H2O = 3'-GMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12172", "l": "alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)"}, {"i": "EC:3.5.99.6", "l": "\"Glucosamine-6-phosphate deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13705", "l": "alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + UDP-N-acetyl-alpha-D-glucosamine = alpha-D-Man-(1->3)-[alpha-D-GlcNAc-(1->2)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + H(+) + UDP"}, {"i": "EC:2.4.1.138", "l": "\"Mannotetraose 2-alpha-N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52472", "l": "16alpha,17beta-estriol + UDP-alpha-D-glucuronate = 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166538", "l": "The bound receptor dimerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45417", "l": "11-oxo-5Z,9,12E,14E-prostatetraenoate + H2O => 15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50532", "l": "acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195378", "l": "Homodimerization of VEGF proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53355", "l": "5,6-dihydrouridine(20b) in tRNA + NAD(+) <=> H(+) + NADH + uridine(20b) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43299", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938201", "l": "MYL9 gene transcription is stimulated by RUNX1:CBFB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688294", "l": "SIRT5 deacetylates Cytochrome C (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904841", "l": "TORC2 complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2090079", "l": "GLB1 hydrolyses linker chain(2) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22909", "l": "3',5'-cyclic AMP + H(+) + H2O => 3',5'-cyclic IMP + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54911", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH <=> (4E)-hexenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33035", "l": "2-oxospirilloxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = 2,2'-dioxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51045", "l": "indole-3-pyruvate imine dimer => CO2 + NH4(+) + protodeoxyviolaceinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54855", "l": "H(+) + heptan-4-one + NADPH + O2 <=> H2O + NADP(+) + propyl butanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44979", "l": "(R)-carnitine + propanoyl-CoA <=> CoA + O-propanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983707", "l": "SYK autophosphorylates at the activated BCR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30495", "l": "N-hydroxy-L-valine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950456", "l": "IL12B dimerizes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48768", "l": "ATP + D-erythrulose = ADP + D-erythrulose 4-phosphate + H(+)"}, {"i": "EC:2.7.1.210", "l": "\"D-erythrulose 4-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16379", "l": "biliverdin IXalpha + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693347", "l": "HTR1A binds 5HT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4411373", "l": "NLK translocates to nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35007", "l": "D-fucose(in) = D-fucose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21532", "l": "ATP + glutathione + glutathionylspermidine = ADP + H(+) + phosphate + trypanothione"}, {"i": "EC:6.3.1.9", "l": "\"Trypanothione synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29899", "l": "ATP + D-xylose(out) + H2O = ADP + D-xylose(in) + H(+) + phosphate"}, {"i": "EC:7.5.2.10", "l": "\"ABC-type D-xylose transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45686", "l": "N-dodecanoyl-sphing-4-enine-1-phosphate(out) => N-dodecanoyl-sphing-4-enine-1-phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198371", "l": "AKT phosphorylates GSK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203979", "l": "Coat Assembly (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58444", "l": "N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944246", "l": "Association of procollagen type XXI (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32132", "l": "(2S)-ethylmalonyl-CoA + H(+) => butanoyl-CoA + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784959", "l": "BPHL hydrolyses VACV to ACV (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798257", "l": "PTPRS binds NTRK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5591086", "l": "SERPINA5 binds activated protein C (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8935732", "l": "RUNX1 binds SIN3A,(SIN3B) co-repressor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55365", "l": "(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate => all-trans-nonaprenyl diphosphate + 6 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2467811", "l": "Separation of sister chromatids (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-555065", "l": "Formation of clathrin coated vesicle (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709360", "l": "H2O2 reduces MetHb (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35225", "l": "2-hydroxy-dAMP + H(+) + phosphate => 2-oxo-dADP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30755", "l": "ATP + carbamate = ADP + carbamoyl phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102261", "l": "8-hydroxy-5-deazaflavin:NADPH oxidoreductase activity"}, {"i": "MetaCyc:RXN-12450"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43441", "l": "hexadecanoate + sphinganine => H2O + N-hexadecanoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0015924", "l": "mannosyl-oligosaccharide mannosidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047086", "l": "ketosteroid monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004990", "l": "oxytocin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54228", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine = 2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004656", "l": "procollagen-proline 4-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36125", "l": "gibberellin A20 methyl ester + S-adenosyl-L-homocysteine => gibberellin A20 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951499", "l": "Loading of antigenic peptides on to class I MHC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15750", "l": "(S)-mandelate + A => AH2 + phenylglyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64171", "l": "2-ethyl-L-serine <=> (2S)-2-aminobutanoate + formaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029988", "l": "Dimerization of overexpressed FGFR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706340", "l": "Active FLT3:p-Y-GRB10 binds PIK3R1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357845", "l": "RIPK1 is deubiquitinated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60520", "l": "2 H2O + L-cystine-bis-glycine = 2 glycine + L-cystine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40712", "l": "1-octadecanoylglycerone 3-phosphate + hexadecan-1-ol => 1-O-hexadecylglycerone 3-phosphate + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322422", "l": "Beta-catenin recruits SMARCA4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51816", "l": "ATP(in) + CoA(in) + dodecanoate(out) + H(+)(out) = AMP(in) + diphosphate(in) + dodecanoyl-CoA(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21386", "l": "(E)-cinnamate + NH4(+) => L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51887", "l": "L-proline betaine <=> D-proline betaine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19925", "l": "D-ribitol 5-phosphate + NAD(+) = D-ribulose 5-phosphate + H(+) + NADH"}, {"i": "EC:1.1.1.137", "l": "\"Ribitol-5-phosphate 2-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10664", "l": "NAD(+) + perillyl alcohol = H(+) + NADH + perillyl aldehyde"}, {"i": "EC:1.1.1.144", "l": "\"Perillyl-alcohol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51563", "l": "(S)-bulbocapnine + S-adenosyl-L-methionine <=> (S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31604", "l": "(Z)-3-ureidoacrylate + H2O => (Z)-3-aminoacrylate + carbamate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027033", "l": "Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14(S)-HDHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50397", "l": "(2-aminobenzoyl)acetate + H(+) + octanoyl-CoA => 2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47059", "l": "4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689000", "l": "AADAC deacetylates PHEN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624112", "l": "CEBPA binds CDK4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64335", "l": "ATP + CoA + nicotinate <=> AMP + diphosphate + nicotinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198513", "l": "Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2172678", "l": "PHF8 demethylates histone H4K20me1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33255", "l": "2-demethylmenaquinol-7 + S-adenosyl-L-methionine = H(+) + menaquinol-7 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63614", "l": "prunetin-5-O-beta-D-glucuronide + UDP => prunetin + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19445", "l": "2,3-dihydroxyindole + O2 = anthranilate + CO2 + H(+)"}, {"i": "EC:1.13.11.23", "l": "\"2,3-dihydroxyindole 2,3-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27542", "l": "methanol + N,N-dimethyl-4-nitrosoaniline = 4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046423", "l": "allene-oxide cyclase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32650", "l": "erythromycin C + S-adenosyl-L-methionine <=> erythromycin A + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174963", "l": "NAT1 acetylation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30307", "l": "7-methylxanthine + H(+) + NADPH + O2 = formaldehyde + H2O + NADP(+) + xanthine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036169", "l": "3-methoxy-4-hydroxy-5-decaprenylbenzoic acid decarboxylase activity"}, {"i": "REACT:R-HSA-2162195", "l": "MHDB is decarboxylated to DMPhOH by MHDB decarboxylase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27981", "l": "GDP-alpha-D-mannose + H2O <=> alpha-D-mannose 1-phosphate + GMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106153", "l": "phosphorylated histone binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28314", "l": "baicalein + UDP-alpha-D-glucuronate = baicalin + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043995", "l": "histone acetyltransferase activity (H4-K5 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47488", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH = isodeoxycholate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635853", "l": "Hh-dependent expression of GLI1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27669", "l": "(R)-methylmalonyl-CoA + H(+) <=> CO2 + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23072", "l": "H(+) + oxaloacetate + phosphate = CO2 + H2O + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27327", "l": "3-dehydro-6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29481", "l": "(+)-epicubenol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110157", "l": "UNG glycosylase mediated recognition and binding of a 5-hydroxyuracil opposite to a guanine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865498", "l": "KMT2A trimethylates nucleosomes at the SPI1 gene locus producing H3K4Me3 mark (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391168", "l": "SIRP gamma binds CD47 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45242", "l": "a (2E,4E)-(5,6-saturated)-dienoyl-CoA => a (3E,5Z)-dienoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32732", "l": "a diacylglycerol + H2O => a fatty acid + a monoacylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465940", "l": "atRAL is reduced to atROL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168136", "l": "NOTCH3 binds DLL4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5683593", "l": "ATG7:ATG3:LC3 dissociates (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047259", "l": "glucomannan 4-beta-mannosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54661", "l": "an aromatic (S)-hydroxynitrile => an aromatic aldehyde + hydrogen cyanide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38142", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16752", "l": "H2O + phosphonoacetate <=> acetate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951966", "l": "EP300 acetylates RUNX3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21503", "l": "UDP-alpha-D-glucose <=> H2O + UDP-4-dehydro-6-deoxy-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33238", "l": "2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 <=> 3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20678", "l": "alizarin + UDP-alpha-D-glucose => 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177479", "l": "Axonal transport of NGF:Trk complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004610", "l": "phosphoacetylglucosamine mutase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373147", "l": "succinate + FAD <=> fumarate + FADH2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29486", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-beta-selinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948612", "l": "miR-19b microRNA binds CNOT6L mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395992", "l": "p-T,4S-IRF3 is dimerized (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60690", "l": "(11R)-dihydroartemisinate + 2 H(+) + NADH => (11R)-dihydroartemisinic aldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170674", "l": "Dissociation of the Gi alpha:G olf complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120020", "l": "cholesterol transfer activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24251", "l": "glyoxylate + L-alanine <=> glycine + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14635", "l": "ADP + H(+) + Na(+)(out) + phosphate => ATP + H2O + Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54357", "l": "3-methyl-2-oxobutanoate + H(+) => 2-methylpropanal + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16627", "l": "CoA + thioacetate => acetyl-CoA + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54707", "l": "N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42350", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + ADP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351207", "l": "Spermine  => N-acetylated spermine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26435", "l": "indole + L-serine => H2O + L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050195", "l": "phosphoribokinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655270", "l": "Activated FGFR3 mutants phosphorylate FRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13169", "l": "maleate = fumarate"}, {"i": "EC:5.2.1.1", "l": "\"Maleate isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59394", "l": "CoA + O-acetyl-L-seryl-[protein] => acetyl-CoA + L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "74.603620314006946", "identifiers": [{"i": "GO:0016813", "l": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"}, {"i": "EC:3.5.3.-", "l": "\"In linear amidines\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685606", "l": "CLEC2D binds KLRB1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22770", "l": "4-nitroaniline + 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one => 4-nitrophenyl-3-ketovalidamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864453", "l": "TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers bind the ERBB2 gene promoter and recruit YY1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64781", "l": "S-benzyl-L-cysteine => 2-aminoprop-2-enoate + benzylthiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30997", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + soyasapogenol B => O2 + reduced [NADPH--hemoprotein reductase] + sophoradiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13029", "l": "H2O + N-acetyl-D-glucosamine + O2 = H(+) + H2O2 + N-acetyl-D-glucosaminate"}, {"i": "EC:1.1.3.29", "l": "\"N-acylhexosamine oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11969", "l": "AH2 + kynurenate + O2 => 7,8-dihydro-7,8-dihydroxykynurenate + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56159", "l": "(12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine <=> (12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38244", "l": "(9Z)-octadecenoyl-CoA + eicosan-1-ol => 1-O-eicosanyl (9Z)-octadecenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110311", "l": "POLZ extends translesion synthesis (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35064", "l": "H2O + pyrazinamide => NH4(+) + pyrazine-2-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193964", "l": "CYP21A2 21-hydroxylates PROG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36139", "l": "(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009282", "l": "CDK1 phosphorylates RUNX2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730847", "l": "Hydrolysis of PIP2 by PLCG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65006", "l": "AMP + decanoyl-[ACP] + diphosphate => ATP + decanoate + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52778", "l": "camalexin + CO2 + 2 H(+) + 4 H2O + hydrogen cyanide + 2 oxidized [NADPH--hemoprotein reductase] => 2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50796", "l": "glutathione + prostaglandin A2 = prostaglandin A2-S-(R)-glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388560", "l": "EDNRA,EDNRB bind EDNs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32749", "l": "ethanolamine(out) => ethanolamine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380574", "l": "Dopamine synaptic vesicle docking and priming (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5252001", "l": "ATP1B4 binds SNW1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48853", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 => 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956050", "l": "NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665515", "l": "P2RX4,7 binds itself to form trimeric non-selective cation channels (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55807", "l": "(R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'-(9Z-octadecenoyl)-3'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-sn-glycerol) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604360", "l": "Initial activation of proMMP2 by MMP14 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38189", "l": "17beta-estradiol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 19-oxotestosterone + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9648089", "l": "NEK6 and NEK7 phosphorylate EML4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17035", "l": "biphenyl-2,3-diol + H(+) + NADH => (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964280", "l": "Active Gq binds BTK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58708", "l": "rifampicin ortho-naphthoquinone carboxamide = rifampicin para-naphthoquinone carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45453", "l": "H2O + N-tetradecanoylethanolamine => ethanolamine + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.21"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48936", "l": "2-oxoglutarate + L-prolyl-[Skp1 protein] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[Skp1 protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31444", "l": "ATP + D-sedoheptulose 7-phosphate => ADP + H(+) + sedoheptulose 1,7-bisphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877003", "l": "CBLL1 ubiqutinates the InlA-bound CDH1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8870466", "l": "RGGT:CHM binds RABs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52002", "l": "an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O => a 1-(methylsulfanyl)-4-aci-nitroalkane + glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672951", "l": "Inactive RAFs bind YWHAB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77094", "l": "Formation of cap binding complex (CBC) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53132", "l": "A + a 3-oxo-Delta(4)-steroid = a 3-oxo-Delta(1,4)-steroid + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18281", "l": "NAD(+) + succinate = fumarate + H(+) + NADH"}, {"i": "EC:1.3.1.6", "l": "\"Fumarate reductase (NADH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50515", "l": "acetyl-CoA + N-terminal L-cysteinyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938773", "l": "RNF144A polyubiquitinates PRKDC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61216", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693198", "l": "RHOD binds effectors at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158300", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381545", "l": "Formation of the IGF:IGFBP5:ALS complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16936", "l": "1-aminocyclopropane-1-carboxylate + H2O <=> 2-oxobutanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38528", "l": "1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50100", "l": "dodecanoyl-CoA + taurine = CoA + H(+) + N-dodecanoyl-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805981", "l": "HMGB1 release from cells (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187586", "l": "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63283", "l": "a 1-acyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 <=> a 1-acyl-2-(15-hydroperoxy-8Z,11Z,13E-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44272", "l": "3 H(+) + 3 malonyl-CoA + octadecanoyl-CoA = 4-hydroxy-6-(2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029451", "l": "Activation of RAC1 by VAV (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33100", "l": "acetyl-CoA + spermine => CoA + H(+) + N(1)-acetylspermine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956684", "l": "ITCH polyubiquitinates TP73 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222342", "l": "Hydroperoxyl enters the bacterium (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390649", "l": "CHRM1,3,5 bind acetylcholine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10848", "l": "an [alpha-factor](in) + ATP + H2O = ADP + an [alpha-factor](out) + H(+) + phosphate"}, {"i": "EC:7.4.2.7", "l": "\"ABC-type alpha-factor-pheromone transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198513", "l": "Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687107", "l": "MAPK4,6 translocate to nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33884", "l": "2-deoxy-scyllo-inosamine + NAD(+) => 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102704", "l": "GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity"}, {"i": "MetaCyc:RXN-5463"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42805", "l": "5,6,7,8-tetrahydromethanopterin + A => 7,8-dihydromethanopterin + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58421", "l": "NADP(+) + prenol => 3-methyl-2-butenal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682388", "l": "Autophagosome maturation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17336", "l": "O-acetyl-L-serine + zeatin <=> acetate + H(+) + L-lupinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51634", "l": "all-trans-(4S,16)-dihydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-(4S)-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004057", "l": "arginyltransferase activity"}, {"i": "MetaCyc:ARGINYLTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21843", "l": "N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42391", "l": "beta-D-glucosyl crocetin + UDP-alpha-D-glucose <=> beta-D-gentiobiosyl crocetin + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15120", "l": "3'-dephospho-CoA + ATP <=> 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799097", "l": "ATM phosphorylates ZNF420 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36470", "l": "H2O + L-alanylglycine <=> glycine + L-alanine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031872", "l": "type 1 proteinase activated receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656382", "l": "TGFBR2 does not recruit TGFBR1 LBD Mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983152", "l": "Transfer of ubiquitin from E1 to E2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693012", "l": "TNFSF15 binds TNFRSF25 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111956", "l": "Calmodulin activates Cam-PDE 1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59121", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + H(+) => 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186771", "l": "RNF111 binds SMAD7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9656947", "l": "OGG1beta translocates to mitochondria (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166387", "l": "The FA anion diffuses away laterally from UCP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64652", "l": "(E)-4-coumaraldehyde + CoA + NADP(+) = (E)-4-coumaroyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28322", "l": "UDP-alpha-D-glucuronate + wogonin = UDP + wogonin 7-O-beta-D-glucuronate"}, {"i": "EC:2.4.1.253", "l": "\"Baicalein 7-O-glucuronosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12955", "l": "ADP + H(+) + O-phospho-L-seryl-[Goodpasture antigen-binding protein] => ATP + L-seryl-[Goodpasture antigen-binding protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48514", "l": "ADP + H(+) + phosphate + phosphinate(in) => ATP + H2O + phosphinate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4088134", "l": "PLK1 phosphorylates FOXM1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32691", "l": "(2E)-geranyl diphosphate = (E)-beta-ocimene + diphosphate"}, {"i": "EC:4.2.3.106", "l": "\"(E)-beta-ocimene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24897", "l": "5-hydroxyxanthotoxin + S-adenosyl-L-methionine <=> isopimpinellin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5213464", "l": "RIPK1 is phosphorylated (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49048", "l": "25-hydroxyvitamin D2 + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 1alpha,25-dihydroxyvitamin D2 + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444647", "l": "C3a receptor binds anaphylatoxin C3a (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769383", "l": "CBY1 binds beta-catenin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983424", "l": "Budding of COPII coated vesicle (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0003953", "l": "NAD+ nucleosidase activity"}, {"i": "REACT:R-HSA-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879459", "l": "F-actin capping protein is a heterodimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10245", "l": "4-fumarylacetoacetate + H2O => acetoacetate + fumarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50406", "l": "1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein] => (2-aminobenzoyl)acetate + H(+) + S-octanoyl-L-cysteinyl-[PqsC protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30146", "l": "H2O + octanoyl-CoA <=> CoA + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21218", "l": "ADP + alpha-D-ribose 1,5-bisphosphate + H(+) => ATP + D-ribose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005043", "l": "netrin receptor activity involved in chemorepulsion"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.139"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24459", "l": "alpha-ribazole 5'-phosphate + H2O <=> alpha-ribazole + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51853", "l": "(9Z,12Z)-octadecadienoate(out) + ATP(in) + CoA(in) + H(+)(out) => (9Z,12Z)-octadecadienoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35528", "l": "H(+) + N-ethylmaleimide + NADH => N-ethylsuccinimide + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48866", "l": "FAD + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine => 2-methylpropan-1-amine + FADH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29734", "l": "beta-maltose(in) <=> beta-maltose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2032781", "l": "WWTR1 (TAZ) binds TEAD (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61905", "l": "betaenone A + H(+) + NADPH + O2 => H2O + NADP(+) + stemphyloxin II"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34002", "l": "5alpha-cholesta-8,24-dien-3beta-ol <=> 5alpha-cholesta-7,24-dien-3beta-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48010", "l": "2,5-dihydroxybenzoyl-CoA + H2O + NAD(+) => 2-hydroxybenzoyl-CoA + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23928", "l": "H2O + N(8)-acetylspermidine = acetate + spermidine"}, {"i": "EC:3.5.1.48", "l": "\"Acetylspermidine deacetylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38372", "l": "1-(9Z-octadecenoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013024", "l": "RHOB binds effectors at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28529", "l": "(R)-carnitine + crotonobetainyl-CoA <=> (R)-carnitinyl-CoA + crotonobetaine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22069", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) => (2S)-2-acetolactate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58553", "l": "15alpha-stemmadenine intermediate II + H2O => (16R)-deshydroxymethyl-stemmadenine + formate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31900", "l": "indole + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + indolin-2-one + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013284", "l": "NOTCH3-ligand complex is cleaved to produce NEXT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48411", "l": "apo-[EntF peptidyl-carrier protein] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[EntF peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13044", "l": "L-dopachrome <=> 5,6-dihydroxyindole-2-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682598", "l": "ATM phosphorylates HERC2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59141", "l": "ATP + citrate + N(5)-[(S)-citryl]-D-ornithine => AMP + diphosphate + H(+) + staphyloferrin A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371582", "l": "HSBP1 binds HSF1 trimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30810", "l": "L-pipecolate + NAD(+) <=> Delta(1)-piperideine-2-carboxylate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938150", "l": "RUNX1:CBFB binds the PRKCQ gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20990", "l": "AMP + 2 H(+) + 2 phosphate => ATP + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632182", "l": "PRMT1 methylates ESRs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51191", "l": "nitric oxide + superoxide <=> peroxynitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57004", "l": "acetyl-CoA + streptothricin D = CoA + H(+) + N(beta)-acetylstreptothricin D"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56246", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl hexadecanoate + apo--[retinol-binding protein] => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14833", "l": "(R)-mevalonate + CoA + 2 NAD(+) = (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH"}, {"i": "EC:1.1.1.88", "l": "\"Hydroxymethylglutaryl-CoA reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2172433", "l": "Collagen type XIX degradation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59091", "l": "D-histidine + S-adenosyl-L-methionine <=> (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61297", "l": "5-deoxy-alpha-D-ribose 1-phosphate => 5-deoxy-D-ribulose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23614", "l": "alpha-santonin + H(+) + NADH => 1,2-dihydro-alpha-santonin + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25950", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H(+) => a 1,2-diacyl-sn-glycerol + CTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75172", "l": "Formation of RAD50:MRE11 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38783", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032145", "l": "succinate-semialdehyde dehydrogenase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36286", "l": "1,7-dimethylxanthine + H(+) + NADPH + O2 <=> 7-methylxanthine + formaldehyde + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045300", "l": "acyl-[acyl-carrier-protein] desaturase activity"}, {"i": "MetaCyc:1.14.19.2-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41431", "l": "L-tyrosine + S-adenosyl-L-methionine <=> 3-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45633", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712190", "l": "cAMP:olfactory CNG channel translocates Na+ and Ca2+ from the extracellular region to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41500", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22603", "l": "H2O + N-acetyl-9-O-acetylneuraminate <=> acetate + H(+) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53578", "l": "20-hydroxy-11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43605", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] => 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25406", "l": "(R)-3-hydroxy-3-methyl-2-oxopentanoate => (S)-2-ethyl-2-hydroxy-3-oxobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39632", "l": "(2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H(+) + NADPH => (16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57206", "l": "N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] => glyoxal + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35965", "l": "fumitremorgin C + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49251", "l": "galactitol(out) + N(pros)-phospho-L-histidyl-[protein] <=> galactitol 1-phosphate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734713", "l": "ORC6 translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41927", "l": "(3R)-hydroxyoctadecanoyl-[ACP] <=> (2E)-octadecenoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25533", "l": "ent-copalyl diphosphate => diphosphate + ent-cassa-12,15-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617484", "l": "EGR2 (KROX20) activates HOXA2 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36270", "l": "caffeine + H(+) + NADH + O2 <=> formaldehyde + H2O + NAD(+) + theobromine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20684", "l": "cis-zeatin + UDP-alpha-D-glucose <=> H(+) + O-beta-D-glucosyl-cis-zeatin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58610", "l": "H2O + 2 monodehydro-L-ascorbate radical + N-decanoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-decanoylglycine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30921", "l": "(3E)-3,4-didehydrorhodopin + AH2 => A + rhodopin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24389", "l": "phosphate + uridine => alpha-D-ribose 1-phosphate + uracil"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615536", "l": "MECP2 and SOX2 bind MIR137 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21808", "l": "2,5-dioxopiperazine + H2O = glycylglycine"}, {"i": "EC:3.5.2.13", "l": "\"2,5-dioxopiperazine hydrolase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047404", "l": "glucuronosyl-disulfoglucosamine glucuronidase activity"}, {"i": "RHEA:15073", "l": "3-D-glucuronosyl-N(2),6-disulfo-beta-D-glucosamine + H2O = D-glucuronate + N(2),6-disulfo-D-glucosamine"}, {"i": "EC:3.2.1.56", "l": "\"Glucuronosyl-disulfoglucosamine glucuronidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26327", "l": "(8Z,11Z)-5-(pentadeca- 8,11,14-trien-1-yl)resorcinol-3-methyl ether + H(+) + S-adenosyl-L-homocysteine => (8Z,11Z)-5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419049", "l": "ROCK activation by RHO (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57967", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54766", "l": "[LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+) => 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57249", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-dGTP => dGTP + glycolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705465", "l": "p-Y-STAT1,3,5 dimer binds SOCS3 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56865", "l": "12 H(+) + 6 malonyl-CoA + NADH + 5 NADPH => (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + 6 CoA + 4 H2O + NAD(+) + 5 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192051", "l": "CYP7A1 7-hydroxylates CHOL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858252", "l": "HDLBP binds HDL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052637", "l": "delta 3-trans-hexadecenoic acid phosphatidylglycerol desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5221061", "l": "TDG excises 5-carboxylcytosine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62787", "l": "2 fonsecin B + H(+) + NADPH + O2 <=> bifonsecin B + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39948", "l": "1,3-diacyl-sn-glycerol + H2O => a fatty acid + a monoacylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.63"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432164", "l": "Ca2+ influx into the post-synaptic cell (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56205", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] => 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047372", "l": "acylglycerol lipase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624211", "l": "Defective SLC16A1 does not cotransport monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21623", "l": "FMNH2 + NAD(+) <=> FMN + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.121", "l": "\"Polymannuronate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019140", "l": "inositol 3-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849435", "l": "PTPN1 dephosphorylates PTK6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674018", "l": "BRAP binds RAS:GTP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52877", "l": "16beta,17beta-estriol + UDP-alpha-D-glucuronate => 16beta,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19543", "l": "H(+) + L-glutamyl 5-phosphate + NADPH => L-glutamate 5-semialdehyde + NADP(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797961", "l": "CHDH oxidises Cho to BETALD (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158795", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5671737", "l": "p-T774-PKN1 binds CDC25C (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54461", "l": "1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010859", "l": "calcium-dependent cysteine-type endopeptidase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55250", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031866", "l": "EP3 subtype prostaglandin E2 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38209", "l": "estrone + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 19-oxo-androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031812", "l": "P2Y1 nucleotide receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60512", "l": "a guanosine in miRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in miRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005044", "l": "scavenger receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12255", "l": "4-O-(beta-D-glucosyl)-trans-coniferol + H2O <=> (E)-coniferol + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399952", "l": "Phosphorylation of LIMK-1 by PAK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56662", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38887", "l": "H2O + N-hexanoyl-sphinganine = hexanoate + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618328", "l": "ATAT acetylates microtubules (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.295", "l": "\"2-methyl-6-phytyl-1,4-hydroquinone methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5213462", "l": "RIPK3 binds RIPK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213239", "l": "Formation of MHC II alpha beta heterodimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20668", "l": "1,5-anhydro-D-glucitol + NADP(+) <=> 1,5-anhydro-D-fructose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53113", "l": "3alpha-hydroxy-5alpha-androstane 17-O-(beta-D-glucuronate) + NADP(+) => 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937792", "l": "RUNX3 binds SRC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5632677", "l": "PTCH is internalized (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32151", "l": "9alpha-copalyl diphosphate = (12E)-9alpha-labda-8(17),12,14-triene + diphosphate"}, {"i": "EC:4.2.3.99", "l": "\"Labdatriene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-398185", "l": "LARG binds plexin B1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428909", "l": "Activated TP receptor binds G-protein  G13 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59720", "l": "D-maltohexaono-1,5-lactone + H2O = D-maltohexaonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49890", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2 => (1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43162", "l": "H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine => adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391867", "l": "Fyn binds NCAM1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912409", "l": "NOTCH3 mRNA translation controlled by miRNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432909", "l": "Interaction of Plectin with Integrin beta 4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031757", "l": "Edg-4 lysophosphatidic acid receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14834", "l": "(R)-mevalonate + CoA + 2 NAD(+) => (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047547", "l": "2-methylcitrate dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635845", "l": "GLI proteins bind CDC73 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2197698", "l": "Src phosphorylate WASP,N-WASP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17747", "l": "beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP => N-acetyl-D-glucosamine + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696465", "l": "USP45 deubiquitinates ERCC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50928", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810376", "l": "ING2 binds PI5P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018564", "l": "carbazole 1,9a-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23816", "l": "2-oxoglutarate + putrescine = 4-aminobutanal + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033839", "l": "flavonol-3-O-glycoside glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41314", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl (5Z,8Z,10E,12R,14Z)-hydroperoxyiecosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53894", "l": "a prenal + H2O2 + L-cysteine => an S-prenyl-L-cysteine + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65093", "l": "asperaculane G + O2 + reduced [NADPH--hemoprotein reductase] => aculene D + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52971", "l": "hyocholate + UDP-alpha-D-glucuronate <=> H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373867", "l": "BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38391", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33770", "l": "a 3-hydroxy-fatty acyl-CoA <=> a (2E)-enoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35568", "l": "H2O + N-(9Z,12Z-octadecadienoyl)-ethanolamine => (9Z,12Z)-octadecadienoate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047734", "l": "CDP-glycerol diphosphatase activity"}, {"i": "MetaCyc:CDP-GLYCEROL-PYROPHOSPHATASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41723", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.-.-", "l": "\"Oxidizing metal ions\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46793", "l": "2 [Fe(II)-cytochrome b5] + an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46652", "l": "epitestosterone + H(+) + NADPH = 5beta-dihydroepitestosterone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672177", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060182", "l": "apelin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14294", "l": "D-glucose + NAD(+) => D-glucono-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47938", "l": "4-hydroxybenzoate + 2 H(+) + NADPH => 4-hydroxybenzaldehyde + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53424", "l": "a fatty acyl-CoA + a sphingoid base = an N-acyl-sphingoid base + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202692", "l": "PIP3 binds to RhoA and activates it (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52177", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1912357", "l": "ITCH ubiquitinates DTX (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39525", "l": "(2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29348", "l": "2 H(+)(in) + orotate(in) => 2 H(+)(out) + orotate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466861", "l": "Defective RDH12 does not reduce atRAL to atROL and causes LCA13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30951", "l": "(2E,6E)-farnesyl diphosphate + H2O = alpha-eudesmol + diphosphate"}, {"i": "EC:4.2.3.85", "l": "\"Alpha-eudesmol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210912", "l": "Furin cleaves ANTXR2-bound pagA to yield pagA(197-794) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052638", "l": "indole-3-butyrate beta-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.7", "l": "\"Glu-Glu dipeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48645", "l": "prostaglandin H2 => (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47221", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] => 3beta,16alpha-dihydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31997", "l": "7-epi-sesquithujene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035987", "l": "Defective HLCS does not biotinylate 6xMCCC1:6xMCCC2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14151", "l": "H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP => luteolin 7-O-beta-D-glucuronide + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784765", "l": "p-Y705-STAT3 dimerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17272", "l": "macrocin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + tylosin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166792", "l": "Conversion of C2 into C2a and C2b (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374899", "l": "Release of noradrenaline  at the synapse (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48400", "l": "2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit]"}, {"i": "EC:1.14.11.29", "l": "\"Hypoxia-inducible factor-proline dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56553", "l": "ATP + L-threonyl-[rhodopsin] => ADP + H(+) + O-phospho-L-threonyl-[rhodopsin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34140", "l": "Delta(9)-tetrahydrocannabinolate + H(+) => CO2 + Delta(9)-tetrahydrocannabinol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034817", "l": "cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614933", "l": "ACEIs bind ACE (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373741", "l": "SDK2 homophillic interaction (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35777", "l": "2-oxoglutaramate + UDP-alpha-D-kanosamine => L-glutamine + UDP-3-oxo-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018768", "l": "RHOU auto-activates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8858270", "l": "HILPDA binds lipid droplets (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11068", "l": "(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O = (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose"}, {"i": "EC:3.2.1.107", "l": "\"Protein-glucosylgalactosylhydroxylysine glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62987", "l": "H2O + hexadecanamide <=> hexadecanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018491", "l": "2-oxobutyrate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66998", "l": "2-methylpentanoyl-CoA + AMP + diphosphate => 2-methylpentanoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42907", "l": "guanosine(748) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(748) in 23S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25275", "l": "ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate => ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614544", "l": "Sulfite is oxidized to sulfate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005462", "l": "UDP-N-acetylglucosamine transmembrane transporter activity"}, {"i": "REACT:R-HSA-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683593", "l": "ATG7:ATG3:LC3 dissociates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174157", "l": "Degradation of multiubiquitinated Cyclin B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5099899", "l": "WNT5A binds FZD4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433395", "l": "Dimerization of sSCF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63561", "l": "angiotensin I + H2O => angiotensin II + L-histidyl-L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5226999", "l": "ADD1:ADD3 binds DMTN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392295", "l": "Gbeta:gamma recruits PI3K gamma (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22793", "l": "isonocardicin A => nocardicin A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40834", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132122", "l": "Activation of C1r within the C1complement complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001517", "l": "N-acetylglucosamine 6-O-sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214956", "l": "Full-length EA is cleaved by SNK serine protease (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36684", "l": "hexadecanoyl-CoA + L-cysteinyl-[protein] => CoA + S-hexadecanoyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61323", "l": "(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + parthenolide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48475", "l": "ganglioside GT1a + H2O <=> ganglioside GD1a + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39304", "l": "(3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA => (2E,11Z,14Z)-eicosatrienoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103116", "l": "ABC-type D-galactofuranose transporter"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730842", "l": "PI3K associates with phosphorylated GAB2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45922", "l": "4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA => 16-hydroxyhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25884", "l": "carbamoyl phosphate + N(2)-succinyl-L-ornithine = H(+) + N(2)-succinyl-L-citrulline + phosphate"}, {"i": "EC:2.1.3.11", "l": "\"N-succinylornithine carbamoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51344", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8,9-epoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112037", "l": "Inactivation of PLC beta (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50938", "l": "acetoacetyl-CoA + L-glutamate => (3S)-3-aminobutanoyl-CoA + 2-oxoglutarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56270", "l": "CMP + H(+) + N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13191", "l": "3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+) => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50400", "l": "L-cysteinyl-[PqsC protein] + octanoyl-CoA = CoA + S-octanoyl-L-cysteinyl-[PqsC protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52585", "l": "chenodeoxycholoyl-CoA + NAD(+) => 7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21008", "l": "diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+) = diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH"}, {"i": "EC:1.1.1.229", "l": "\"Diethyl 2-methyl-3-oxosuccinate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59216", "l": "(indol-3-yl)acetate + H(+) = CO2 + skatole"}, {"i": "EC:4.1.1.115", "l": "\"Indoleacetate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004298", "l": "threonine-type endopeptidase activity"}, {"i": "EC:3.4.25.-", "l": "\"Threonine endopeptidases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602316", "l": "Defective MyD88 does not oligomerize within the complex of activated TLR5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32137", "l": "CO2 + H(+) + propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] => 2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54539", "l": "a very long-chain fatty acid + ATP + CoA <=> a very long-chain fatty acyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191303", "l": "FDPS dimer transfers IPPP to GPP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65001", "l": "holo-[ACP] + octanoyl-AMP => AMP + H(+) + octanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392129", "l": "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14830", "l": "hydrogen sulfide + O-acetyl-L-serine => acetate + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34561", "l": "1-deoxy-11-oxopentalenate + H(+) + NADH => 1-deoxy-11beta-hydroxypentalenate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0010461", "l": "light-activated ion channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60959", "l": "17-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose <=> (9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59506", "l": "[protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein] => cholesterol + glycyl-L-cysteinyl-[protein] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60328", "l": "L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.360", "l": "\"[Histone H3]-lysine(79) N-trimethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905538", "l": "polysome binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33993", "l": "alpha-copaene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013145", "l": "RAC1 binds effectors at the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.171"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49022", "l": "4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide => 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14902", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => casbene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59002", "l": "H(+) + H2O2 + propanoate => H2O + O2 + propanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38088", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617642", "l": "HOXD3 gene is transcribed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23625", "l": "a 5,6-dihydrouridine in tRNA + NADP(+) => a uridine in tRNA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004826", "l": "phenylalanine-tRNA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66103", "l": "3-(4-hydroxyphenyl)pyruvate + L-kynurenine <=> H2O + kynurenate + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48502", "l": "glycerol + H(+) + octanoate => H2O + octanoylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26408", "l": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4(+) <=> H(+) + 4 H2O + phosphate + pyridoxal 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41304", "l": "H2O + N-dodecanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + dodecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31017", "l": "CO2 + indole => H(+) + indole-3-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30840", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-talose => UDP-N-acetyl-beta-L-fucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61886", "l": "1-O-methyl-9-hydroperoxy-20-hydroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate => 1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2282889", "l": "Defective ARSB does not hydrolyse C4S/C6S chains (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51273", "l": "(9Z)-octadecenoyl-CoA + glycine => CoA + H(+) + N-(9Z-octadecenoyl)glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65091", "l": "asperaculane E + O2 + reduced [NADPH--hemoprotein reductase] <=> asperaculane G + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008607", "l": "phosphorylase kinase regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50266", "l": "26-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807872", "l": "Active ARF recruits coatomer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13312", "l": "H2O + NAD(+) + vanillin <=> 4-hydroxy-3-methoxybenzoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22057", "l": "hexadecan-1-ol + NAD(+) => H(+) + hexadecanal + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418106", "l": "Packaging of telomere ends (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29902", "l": "ATP + D-xylose(out) + H2O <=> ADP + D-xylose(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.146", "l": "\"Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164515", "l": "Fusogenic activation of gp41 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450975", "l": "isocitrate <=> citrate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450466", "l": "AUF1:mRNA complex is destroyed (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63505", "l": "daunorubicin + H(+) + NADPH => 13-dihydrodaunorubicin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007467", "l": "The PRC1L4 complex binds the CDC7 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11693", "l": "NAD(+) + NADPH => NADH + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28376", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine => ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54792", "l": "[nsP1 protein]-L-histidine + N(7)-methyl-GTP = [nsP1 protein]-N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidine + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416358", "l": "G alpha (q) inhibits PI3K alpha (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429714", "l": "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191299", "l": "Squalene is oxidized to its epoxide (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14566", "l": "(11Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxo-(13Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48240", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1b = CMP + ganglioside GT1b + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015043", "l": "leghemoglobin reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28470", "l": "pyridoxine(in) = pyridoxine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57453", "l": "L-glutaminyl-[protein] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0071568", "l": "UFM1 transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052914", "l": "16S rRNA (guanine(1207)-N(2))-methyltransferase activity"}, {"i": "RHEA:42736", "l": "guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.172", "l": "\"16S rRNA (guanine(1207)-N(2))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799332", "l": "ATR phosphorylates TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39514", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA <=> (2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55358", "l": "13-cis-retinol => 11-cis-retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51119", "l": "guanosine(6) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19297", "l": "ATP + beta-alanine + L-histidine = ADP + carnosine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14142", "l": "AMP + glutathione disulfide + 2 H(+) + sulfite => adenosine 5'-phosphosulfate + 2 glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951676", "l": "RUNX3 binds TEADs and YAP1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0000033", "l": "alpha-1,3-mannosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18439", "l": "4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+) => 4-CDP-2-C-methyl-D-erythritol + ATP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033411", "l": "UAA codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21229", "l": "alpha-maltose => beta-maltose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.52"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008269", "l": "JAK pathway signal transduction adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45054", "l": "CoA + O-(2E)-butenoyl-(R)-carnitine => (2E)-butenoyl-CoA + (R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.25", "l": "\"Bacteriophage T(4) restriction endoribonuclease RegB\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55623", "l": "a carotenoid psi-end group <=> a carotenoid beta-end derivative"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23620", "l": "ATP + N(2)-(2-carboxyethyl)-L-arginine = AMP + deoxyamidinoproclavaminate + diphosphate + H(+)"}, {"i": "EC:6.3.3.4", "l": "\"(Carboxyethyl)arginine beta-lactam-synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34833", "l": "N-acyl-15-methylhexadecasphing-4-enine + phosphate => H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429698", "l": "PRKD1,2,3 phosphorylates COL4A3BP-2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5671737", "l": "p-T774-PKN1 binds CDC25C (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36666", "l": "(S)-1-pyrroline-5-carboxylate + H(+) + H2O + malonyl-CoA <=> (2S,5S)-5-carboxymethylproline + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8963851", "l": "VD3 dissociates from GC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110219", "l": "Cleavage of thymine by TDG glycosylase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8953037", "l": "E2F8 forms homodimers (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51688", "l": "galactitol + NAD(+) = H(+) + keto-L-tagatose + NADH"}, {"i": "EC:1.1.1.406", "l": "\"Galactitol 2-dehydrogenase (L-tagatose-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44856", "l": "(9Z)-octadecenoyl-CoA + (R)-carnitine = CoA + O-(9Z)-octadecenoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64308", "l": "3-aminobutanoate + pyruvate = acetoacetate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684248", "l": "SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55984", "l": "(R)-mandelonitrile + UDP-alpha-D-glucose = (R)-prunasin + H(+) + UDP"}, {"i": "EC:2.4.1.354", "l": "\"(R)-mandelonitrile beta-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990738", "l": "pseudouridine 5'-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428127", "l": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23530", "l": "citramalyl-CoA + succinate => citramalate + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654511", "l": "FGFRL1 dimer binds FGFs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20609", "l": "2-dehydro-3-deoxy-D-arabinonate = glycolaldehyde + pyruvate"}, {"i": "EC:4.1.2.28", "l": "\"2-dehydro-3-deoxy-D-pentonate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985343", "l": "RUNX2 binds SOX9 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63137", "l": "adenosylcob(III)alamin + apo--[alkylcobalamin reductase] + glutathione => cob(I)alamin--[alkylcobalamin reductase] + H(+) + S-adenosylglutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13479", "l": "H(+) + indole-3-pyruvate + NADPH + NH4(+) => H2O + L-tryptophan + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198314", "l": "DAG stimulates protein kinase C-delta (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625124", "l": "GCK gene expression is inhibited by FOXO1, SIN3A and HDACs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38835", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62611", "l": "glutathione + H(+) + hydrogen sulfide + ubiquinone-10 <=> S-sulfanylglutathione + ubiquinol-10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.68"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730899", "l": "Oligomerization of BCL10 and MALT1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20942", "l": "1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 1,3,4-trisphosphate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39692", "l": "(2E,11Z)-octadecadienoyl-CoA + H(+) + NADPH => (11Z)-octadecenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.30"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036423", "l": "hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45286", "l": "CoA + H(+) + N-eicosanoyl-sphing-4-enine => eicosanoyl-CoA + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008662", "l": "1-phosphofructokinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351208", "l": "Spermidine  => N-acetylated spermidine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944263", "l": "Association of procollagen type II (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24971", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> H2O + 2 oxidized [adrenodoxin] + secalciferol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "78.423603998002051", "identifiers": [{"i": "GO:0008227", "l": "G protein-coupled amine receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28413", "l": "4-(gamma-L-glutamylamino)butanal + H2O + NADP(+) <=> 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20256", "l": "(2R,3S)-2,3-dimethylmalate <=> dimethylmaleate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2214351", "l": "PLK1 phosphorylates GORASP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0033694", "l": "oxidoreductase activity, acting on the CH-NH group of donors, iron-sulfur protein as acceptor"}, {"i": "EC:1.5.7.-", "l": "\"With an iron-sulfur protein as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36862", "l": "(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912450", "l": "ATR Kinase is recruited to unsynapsed regions (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.70"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43812", "l": "1,2-dioctadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39051", "l": "ATP + cholesterol(in) + H2O = ADP + cholesterol(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050605", "l": "superoxide reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507719", "l": "p62:MEKK3 binds to TRAF6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220981", "l": "NOTCH1 PEST domain mutants stimulate HEY transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168640", "l": "Ubiquitinated IkB is degraded (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15358", "l": "5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose => demethyllactenocin + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839114", "l": "BCR-FGFR1:GRB2:p-GAB2 binds PIK3R1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944454", "l": "mTORC1 phosphorylates MAF1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0034215", "l": "thiamine:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77081", "l": "Formation of the CE:GMP intermediate complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16956", "l": "2-oxoglutarate + N(2)-succinyl-L-ornithine <=> L-glutamate + N-succinyl-L-glutamate 5-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9733960", "l": "Bile salts and acids dissociate from ALB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388855", "l": "Prolactin-releasing hormone receptor binds PRH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853801", "l": "PSPN binds RET:GFRA4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34244", "l": "GTP + H(+) + Mo-molybdopterin => diphosphate + Mo-molybdopterin guanine dinucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41585", "l": "dimethylallyl diphosphate + L-tyrosine => 4-O-dimethylallyl-L-tyrosine + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36335", "l": "D-glucuronate + H2O + NAD(+) = D-glucarate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950328", "l": "Expression of Peptidyl-prolyl cis-trans isomerase A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051073", "l": "adenosylcobinamide-GDP ribazoletransferase activity"}, {"i": "RHEA:16049", "l": "adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61942", "l": "3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside + H(+) + UDP => 3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2172666", "l": "RB1 binds condensin II (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40409", "l": "1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34832", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate => N-acyl-15-methylhexadecasphing-4-enine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.70"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5689000", "l": "AADAC deacetylates PHEN (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174438", "l": "Formation of the Flap Intermediate on the C-strand (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24029", "l": "2-oxoglutarate + 4-(trimethylamino)butanoate + O2 => carnitine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55794", "l": "1-hydroxy-2-butanone + H2O + NAD(+) => butan-2-one + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955844", "l": "RBKS phosphorylates ribose to R5P (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "81.790986234327661", "identifiers": [{"i": "GO:0016408", "l": "C-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8934742", "l": "RUNX1 binds PRMT1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38317", "l": "3-hydroxybenzoate + pyruvate => chorismate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73596", "l": "dCMP + H2O => dUMP + NH4+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41485", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814554", "l": "Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31027", "l": "2-trans-(+)-abscisate + UDP-alpha-D-glucose = beta-D-glucopyranosyl trans-(+)-abscisate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40937", "l": "1-O-hexadecylglycerone 3-phosphate + a fatty acid + H(+) => a 1-acylglycerone 3-phosphate + hexadecan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35667", "l": "a triacylglycerol + H2O = a 1,2-diacylglycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871373", "l": "BMX phosphorylates RUFY1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59639", "l": "D-xylotriose + O2 <=> D-xylotriono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983424", "l": "Budding of COPII coated vesicle (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865182", "l": "OTUD7A hydrolyses K11diUb (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35504", "l": "11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 30-hydroxy-11-oxo-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21599", "l": "L-serine + NADP(+) <=> 2-aminomalonate semialdehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20367", "l": "H(+) + N-methylethanolamine phosphate + S-adenosyl-L-homocysteine => phosphoethanolamine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-83656", "l": "TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33986", "l": "(+)-copalyl diphosphate <=> diphosphate + miltiradiene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59158", "l": "AMP + diphosphate + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] => ATP + eicosanoate + holo-[(phenol)carboxyphthiodiolenone synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38917", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+) => a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47494", "l": "isodeoxycholate + NAD(+) => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794357", "l": "SHANK proteins bind GKAPs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202500", "l": "Activation of IKK complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2424485", "l": "Release of p-PLCG1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59475", "l": "2',3'-cGAMP + H2O <=> Gp(2'-5')Ap(3') + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64377", "l": "8 A + a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid => a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 8 AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74734", "l": "Re-integration of insulin receptor into plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050459", "l": "ethanolamine-phosphate phospho-lyase activity"}, {"i": "RHEA:17889", "l": "H2O + phosphoethanolamine = acetaldehyde + NH4(+) + phosphate"}, {"i": "EC:4.2.3.2", "l": "\"Ethanolamine-phosphate phospho-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419428", "l": "S1PR2-5 bind S1P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10964", "l": "ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+)"}, {"i": "EC:2.7.1.17", "l": "\"Xylulokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39141", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA => (2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008867", "l": "galactarate dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602004", "l": "Defective CYP24A1 does not 24-hydroxylate CALTOL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35062", "l": "chloramphenicol(in) + H(+)(out) <=> chloramphenicol(out) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55481", "l": "ent-cassa-12,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => ent-3beta-hydroxycassa-12,15-dien-2-one + 3 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14617", "l": "CoA + glutathione + NADP(+) = CoA-glutathione + H(+) + NADPH"}, {"i": "EC:1.8.1.10", "l": "\"CoA-glutathione reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34198", "l": "2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 2 H(+) + O2 <=> 2 aureusidin 6-O-beta-glucoside + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43385", "l": "ATP + L-arginyl-[protein] => ADP + H(+) + N(omega)-phospho-L-arginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15991", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH => (R)-mevalonate + CoA + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937989", "l": "RUNX1 binds PRC1 complexes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964588", "l": "CCNA2 gene expression is inhibited by RBL1 and RBL2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11186", "l": "beta-alanine + CO2 + NH4(+) => 3-(carbamoylamino)propanoate + 2 H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605591", "l": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683925", "l": "ULK1 is dephosphorylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809764", "l": "SBF1 binds MTMR2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694441", "l": "CSNK1D phosphorylates SEC23 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60048", "l": "a 3beta-hydroxy-4,4-dimethylsteroid + 2 H(+) + 3 NADH + 3 O2 = a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 4 H2O + 3 NAD(+)"}, {"i": "RHEA:60068", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H(+) + 3 NADH + 3 O2 = 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 4 H2O + 3 NAD(+)"}, {"i": "EC:1.14.13.246", "l": "\"4-beta-methylsterol monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400434", "l": "FFAR1 binds fatty acids (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11174", "l": "(6S)-5,6,7,8-tetrahydrofolate + L-methionine => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35457", "l": "(25S)-Delta7-dafachronate + 4 H2O + 3 NADP(+) => 5alpha-cholest-7-en-3-one + 2 H(+) + 3 NADPH + 3 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139918", "l": "Phosphorylation of BIM by JNK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50182", "l": "N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871265", "l": "YAP1 binds TEAD4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717395", "l": "TRPM5 transports Na+ from the extracellular region to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60463", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5226999", "l": "ADD1:ADD3 binds DMTN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58744", "l": "H2O + N(7)-methyl-GTP = diphosphate + H(+) + N(7)-methyl-GMP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047713", "l": "galactitol 2-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55857", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28780", "l": "4-hydroxy-L-threonine => glycine + glycolaldehyde"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990644", "l": "microtubule site clamp"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944457", "l": "MAF1 translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19612", "l": "adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58115", "l": "1''-O-acetyl-ADP-alpha-D-ribose + H2O <=> acetate + ADP-D-ribose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45622", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-butanoyl ethanolamine => H2O + N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27438", "l": "2 glutathione amide + H2O2 => glutathione amide disulfide + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35947", "l": "dihydrochanoclavine-I aldehyde + NADP(+) = chanoclavine-I aldehyde + H(+) + NADPH"}, {"i": "EC:1.3.1.100", "l": "\"Chanoclavine-I aldehyde reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19447", "l": "anthranilate + CO2 + H(+) => 2,3-dihydroxyindole + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210430", "l": "Release of L-Glutamate at the synapse (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15736", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O <=> (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21071", "l": "A + H2O + nitrite <=> AH2 + nitrate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019163", "l": "pyridoxamine-phosphate transaminase activity"}, {"i": "RHEA:15877", "l": "2-oxoglutarate + pyridoxamine 5'-phosphate = D-glutamate + pyridoxal 5'-phosphate"}, {"i": "EC:2.6.1.54", "l": "\"Pyridoxamine-phosphate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847534", "l": "RAB43 hydrolyses GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635102", "l": "GPR161 is internalized (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684290", "l": "nsp3 is glycosylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106293", "l": "NADH oxidase H202-forming activity"}, {"i": "RHEA:11264", "l": "H(+) + NADH + O2 = H2O2 + NAD(+)"}, {"i": "EC:1.6.3.3", "l": "\"NADH oxidase (H(2)O(2)-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362522", "l": "ALDHs oxidise atRAL to atRA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52683", "l": "acetyl-CoA + L-alpha-phenylglycine <=> CoA + H(+) + N-acetyl-L-alpha-phenylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35711", "l": "acetate + succinyl-CoA = acetyl-CoA + succinate"}, {"i": "EC:2.8.3.18", "l": "\"Succinyl-CoA:acetate CoA-transferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047084", "l": "methyltetrahydroprotoberberine 14-monooxygenase activity"}, {"i": "MetaCyc:1.14.13.37-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10230", "l": "cis-aconitate + H2O => citrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.32"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42069", "l": "(3R,5R)-clavulanate-9-aldehyde + H(+) + NADPH => clavulanate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602473", "l": "Autocatalytic activation of MMP1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56646", "l": "a pseudouridine in mRNA => a uridine in mRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26011", "l": "2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) => 3,7-dideoxy-D-threo-hepto-2,6-diuolosonate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35809", "l": "2,5-dioxopentanoate + H2O => 2-dehydro-3-deoxy-D-arabinonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65255", "l": "(2E,6E)-farnesyl diphosphate + 6-hydroxymellein <=> diphosphate + verruculide C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22108", "l": "L-threonine = 2-oxobutanoate + NH4(+)"}, {"i": "EC:4.3.1.19", "l": "\"Threonine ammonia-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23010", "l": "D-glucose + D-glucose 6-phosphate => alpha,alpha-trehalose 6-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140685", "l": "histone H3-di/monomethyl-lysine-9 FAD-dependent demethylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12748", "l": "a 1,4-lactone + H2O <=> a 4-hydroxyacid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55952", "l": "an inositol-1-phosphoceramide + GDP-alpha-D-mannose = a mannosylinositol-1-phospho-N-acyl-sphingoid base + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44632", "l": "(3,5-dihydroxyphenyl)acetyl-CoA + O2 = 2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA + H(+)"}, {"i": "EC:1.13.11.80", "l": "\"(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16240", "l": "[protein]-peptidylproline (omega=180) <=> [protein]-peptidylproline (omega=0)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983422", "l": "Disassembly of COPII coated vesicle (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004574", "l": "oligo-1,6-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44778", "l": "H(+) + menaquinol-6 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-6 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66282", "l": "H(+) + solanidine 3-O-beta-D-glucopyranoside + UDP => solanidine + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25643", "l": "(R)-pulegone + H(+) + NADPH => (1R,4S)-menthone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28884", "l": "H(+)(in) + L-threonine(in) => H(+)(out) + L-threonine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928625", "l": "PAKs autophosphorylate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5444523", "l": "Formation of MSH1:PMS2 Complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2314678", "l": "Aspirin acetylates PTGS1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11128", "l": "4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA = 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "79.238648346243679", "identifiers": [{"i": "GO:0016679", "l": "oxidoreductase activity, acting on diphenols and related substances as donors"}, {"i": "EC:1.10.-.-", "l": "\"Acting on diphenols and related substances as donors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57932", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53128", "l": "delta-carotene = epsilon-carotene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632667", "l": "SMO dimer binds ARRB and KIF3A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9674095", "l": "PDGFRs bind type II TKI (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982017", "l": "Active G alpha (q) binds RGS proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14114", "l": "(DNA)-3'-(deoxyribonucleoside 3',5'-bisphosphate) + H2O => (DNA)-3'-(deoxyribonucleoside 5'-phosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65841", "l": "ATP(out) + Mg(2+)(out) + phosphate(in) => ATP(in) + Mg(2+)(in) + phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13305", "l": "E-sinapate + UDP-alpha-D-glucose = 1-O-(trans-sinapoyl)-beta-D-glucose + UDP"}, {"i": "EC:2.4.1.120", "l": "\"Sinapate 1-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56449", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58823", "l": "H(+) + malonate + Na(+)(in) <=> acetate + CO2 + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15582", "l": "biochanin A 7-O-beta-D-glucoside + malonyl-CoA => biochanin A 7-O-beta-D-glucoside 6''-O-malonate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59499", "l": "(20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + O2 + reduced [NADPH--hemoprotein reductase] <=> (20S)-ginsenoside C-K + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23676", "l": "ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate"}, {"i": "EC:6.3.2.13", "l": "\"UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444202", "l": "Receptor FFAR1 binds free fatty acids (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28729", "l": "Cu(2+)(out) + H(+)(out) => Cu(2+)(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33364", "l": "D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein] => D-mannitol 1-phosphate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33019", "l": "(3S)-3,6-diaminohexanoate + acetyl-CoA = (3S)-6-acetamido-3-aminohexanoate + CoA + H(+)"}, {"i": "EC:2.3.1.264", "l": "\"Beta-lysine N(6)-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46825", "l": "4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 => 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.60", "l": "\"Scutelarin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0071913", "l": "citrate secondary active transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42495", "l": "3'-N-debenzoyl-2'-deoxytaxol + AH2 + O2 <=> 3'-N-debenzoyltaxol + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018798", "l": "RHOV binds GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14246", "l": "ATP + H2O => AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.166", "l": "\"Heparanase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.23"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944229", "l": "Association of procollagen type IX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865454", "l": "CBFB binds RUNX3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869568", "l": "NPM1 binds TFAP2A homodimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2316349", "l": "RALA:GTP binds MYO1C:CALM1 and activates MYO1C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34960", "l": "(R)-carnitine(in) => (R)-carnitine(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990174", "l": "phosphodiesterase decapping endonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786034", "l": "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35318", "l": "H(+) + hexadecanoyl-CoA + malonyl-CoA <=> 3-oxooctadecanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9693111", "l": "RHOF auto-activates (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0010851", "l": "cyclase regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392513", "l": "Rap1 signal termination by Rap1GAPs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797100", "l": "CCNK binds CDK13 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983061", "l": "TSLP binds CRLF2:IL7R (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47710", "l": "ADP-alpha-D-glucose + phosphate => ADP + alpha-D-glucose 1-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39295", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + AH2 + O2 = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22294", "l": "biphenyl-3,5-diol + 4 CO2 + 4 CoA => benzoyl-CoA + 3 H(+) + 3 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25865", "l": "H2O + N(1)-acetylspermidine + O2 => 4-acetamidobutanal + H2O2 + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0016300", "l": "tRNA (uracil) methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39990", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol <=> all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23745", "l": "2-oxoglutarate + L-histidinol phosphate => 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14499", "l": "AH2 + isopyridoxal => A + pyridoxine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785181", "l": "LMF1,2 bind LIPC dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199062", "l": "KLRC1:KLRD1 heterodimer interacts with HLA-E (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429529", "l": "Thrombin binding to GP1b:IX:V (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26457", "l": "NADP(+) + propanoyl-CoA <=> acryloyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.30"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57728", "l": "H(+) + trans-aconitate = CO2 + itaconate"}, {"i": "EC:4.1.1.113", "l": "\"Trans-aconitate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68637", "l": "CDC6 protein is synthesized under the control of E2F transcription factors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000833", "l": "inositol heptakisphosphate 4-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851842", "l": "MUC20 binds MET and inhibits GRB2 binding (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50386", "l": "5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-Glu)(n) => H(+) + oxidized coenzyme F420-(gamma-Glu)(n) + tetracycline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16474", "l": "cyclohexane-1,3-dione + H2O => 5-oxohexanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22183", "l": "(S)-norreticuline + S-adenosyl-L-methionine <=> (S)-norcodamine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177930", "l": "GAB1 phosphorylation by EGFR kinase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12609", "l": "mercaptopurine + S-adenosyl-L-methionine = 6-methylthiopurine + H(+) + S-adenosyl-L-homocysteine"}, {"i": "RHEA:56580", "l": "6-thioguanine + S-adenosyl-L-methionine = 6-methylthioguanine + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.67", "l": "\"Thiopurine S-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28186", "l": "aminoacetone + H2O + O2 = H2O2 + methylglyoxal + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45574", "l": "[alginate](n) => [(1->4)-beta-D-mannuronosyl](n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614614", "l": "Cysteine is degraded to serine and H2S (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37292", "l": "H2O + L-alanyl-L-leucine => L-alanine + L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5627775", "l": "Autophosphorylation of PAK1,2,3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047626", "l": "adenosylmethionine hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17274", "l": "(4-hydroxyphenyl)acetaldehyde + H2O + NAD(+) => 4-hydroxyphenylacetate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35724", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54344", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.48"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.13", "l": "\"Glyceraldehyde-3-phosphate dehydrogenase (NADP(+)) (phosphorylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37701", "l": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-O-octadecyl-sn-glycero-3-phosphocholine + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14343", "l": "2-hydroxy-3-oxoadipate + CO2 => 2-oxoglutarate + glyoxylate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20087", "l": "a flavonol 3-O-(6-O-malonyl-beta-D-glucoside) + CoA => a flavonol 3-O-beta-D-glucoside + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052676", "l": "3-methylbutanol:NAD oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52893", "l": "H2O + NADP(+) + nitrosobenzene => H(+) + NADPH + nitrobenzene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25037", "l": "ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L-seryl-tRNA(Sec)"}, {"i": "EC:2.7.1.164", "l": "\"O-phosphoseryl-tRNA(Sec) kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31809", "l": "alpha-guaiene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869683", "l": "oxPL binds LBP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090580", "l": "phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990254", "l": "keratin filament binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797961", "l": "CHDH oxidises Cho to BETALD (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938217", "l": "RUNX1 binds the SWI/SNF complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39034", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11622", "l": "2-oxopent-4-enoate + chloride + H(+) + NH4(+) => H2O + L-2-amino-4-chloropent-4-enoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33893", "l": "chanoclavine-I aldehyde + H(+) + NADH => chanoclavine-I + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698928", "l": "Late (L) Gene Expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10863", "l": "3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2 <=> 2-(acetamidomethylene)succinate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54374", "l": "(+)-(2S,3R,9R)-pristinol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676591", "l": "2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.78", "l": "\"Mannan endo-1,4-beta-mannosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.7", "l": "\"Peroxisome-assembly ATPase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45897", "l": "an N-acyl-sphingoid base + CDP-ethanolamine => an N-acyl-sphingoid 1-phosphoethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2666278", "l": "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665767", "l": "Activated FMNL3 binds G-actin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3858475", "l": "ppDVL recruits RAC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24018", "l": "CoA + vinorine => 16-epivellosimine + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25293", "l": "ethanol + NAD(+) <=> acetaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65709", "l": "alpha-D-mannose 1-phosphate + GDP-beta-L-galactose => beta-L-galactose 1-phosphate + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19283", "l": "acetone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + psoralen => (7S)-marmesin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51562", "l": "(S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine => (S)-bulbocapnine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102309", "l": "dTDP-4-oxo-2,6-dideoxy-D-glucose 4-ketoreductase (dTDP-D-oliose producing) activity"}, {"i": "MetaCyc:RXN-12930"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30672", "l": "H2O + N,N'-diacetylchitobiose => 2 N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1017228", "l": "Glycoproteins with lesser folding defects get transported back to the ER and the CNX/CRT complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17030", "l": "(S)-allantoin + H2O => allantoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685319", "l": "CX3 complex formation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77589", "l": "Recognition of AAUAAA sequence by CPSF (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52614", "l": "3-(methylsulfanyl)acryloyl-CoA + reduced [electron-transfer flavoprotein] => 3-(methylsulfanyl)propanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51025", "l": "H(+) + NADH + O2 + toluene-4-sulfonate => 4-(hydroxymethyl)benzenesulfonate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37224", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0045236", "l": "CXCR chemokine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.50", "l": "\"Human endogenous retrovirus K endopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47336", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 16beta,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649856", "l": "Oxidative damage to the AP site (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13020", "l": "diphosphate + UMP <=> 5-phospho-alpha-D-ribose 1-diphosphate + uracil"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22444", "l": "(E)-coniferol + NADP(+) = (E)-coniferaldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24773", "l": "7(1)-hydroxychlorophyllide a + NADP(+) => chlorophyllide b + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12035", "l": "a 3-(acyloxy)acyl derivative of bacterial toxin + H2O <=> 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420724", "l": "CASR binds Ca2+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61961", "l": "2 [Fe(II)-cytochrome b5] + a 1-O-hexadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a 1-O-(1Z-hexadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22737", "l": "5-formimidoyltetrahydrofolate + 2 H(+) => 5,10-methenyltetrahydrofolate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51529", "l": "4-hydroxy-3-methoxybenzoate + H(+) => CO2 + guaiacol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13783", "l": "a 2-oxocarboxylate + H2O2 + NH4(+) => an L-alpha-amino acid + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61217", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57333", "l": "H2O + 3 O2 + 3 propionate 3-nitronate => 3 3-oxopropanoate + 3 H(+) + H2O2 + 2 nitrate + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46220", "l": "androst-5-en-3beta,17beta-diol + NAD(+) = 3beta-hydroxyandrost-5-en-17-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65993", "l": "calciol + hnu => 5,6-trans-vitamin D3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38831", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626228", "l": "The distal appendage proteins recruit TTBK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47970", "l": "ganglioside GM3 + N-acetyl-beta-D-galactosamine => ganglioside GM2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964492", "l": "DREAM complex binds the RBL1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66855", "l": "(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate <=> (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003939", "l": "L-iditol 2-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23218", "l": "3-hydroxybenzoyl-CoA + H2O + NADP(+) => benzoyl-CoA + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36771", "l": "beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-beta-L-fucose = alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)"}, {"i": "EC:2.4.1.308", "l": "\"GDP-Fuc:beta-D-Gal-1,3-alpha-D-GalNAc-1,3-alpha-GalNAc-diphosphoundecaprenol alpha-1,2-fucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55478", "l": "2 [Fe(III)-cytochrome b5] + H2O + N-acyl-4-hydroxyeicosasphinganine => 2 [Fe(II)-cytochrome b5] + 2 H(+) + N-acyleicosasphinganine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193702", "l": "Part of the ICD migrates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16443", "l": "L-glutamyl-[protein] + NH4(+) => H2O + L-glutaminyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55876", "l": "apo-[aequorin] + coelenterazine = apo-[aequorin]--coelenterazine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36924", "l": "(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851018", "l": "BTN2A1 binds DC-SIGN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791164", "l": "Expression of SSR1 (Trap alpha) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51855", "l": "(9Z,12Z)-octadecadienoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (9Z,12Z)-octadecadienoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112434", "l": "Formation of DSIF complex  (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28323", "l": "UDP-alpha-D-glucuronate + wogonin => UDP + wogonin 7-O-beta-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52594", "l": "12alpha-hydroxy-3-oxocholan-24-oyl-CoA + H(+) + NADH => deoxycholoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852716", "l": "Thrombin, ELANE cleave C5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17829", "l": "A + CO + H2O = AH2 + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53765", "l": "allocholate + lithocholoyl-CoA => allocholoyl-CoA + lithocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16129", "l": "NADP(+) + pyridoxine = H(+) + NADPH + pyridoxal"}, {"i": "EC:1.1.1.65", "l": "\"Pyridoxine 4-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17346", "l": "(S)-methylmalonyl-CoA + H2O => CoA + H(+) + methylmalonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4720432", "l": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64561", "l": "butan-2-ol + NAD(+) => butan-2-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30866", "l": "4-O-phospho-L-tyrosine + H2O <=> L-tyrosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211959", "l": "CYP3A43 6b-hydroxylates TEST (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685603", "l": "SAP and EAT2 binds SLAMF6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42593", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0098918", "l": "structural constituent of synapse"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53838", "l": "a UDP-2-N,3-O-bis((3R)-3-hydroxyacyl)-alpha-D-glucosamine + H(+) + holo-[ACP] => a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-acyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.314", "l": "\"Germacrene A alcohol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004854", "l": "xanthine dehydrogenase activity"}, {"i": "EC:1.17.1.4", "l": "\"Xanthine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0045125", "l": "bioactive lipid receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52446", "l": "2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981931", "l": "RAC1 and CDC42 activate PAK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2396337", "l": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54692", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (13E)-labda-7,13-dien-15-yl diphosphate"}, {"i": "EC:5.5.1.30", "l": "\"Labda-7,13-dienyl diphosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23459", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 <=> A + crepenynate + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264865", "l": "Caspase-mediated cleavage of Lamin A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43912", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25R)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110215", "l": "Cleavage of uracil by UNG glycosylase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61087", "l": "(2S)-naringenin + 2-oxoglutarate + O2 <=> (2R,3R)-dihydrokaempferol + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12333", "l": "ATP + Fe(3+)(out) + H2O => ADP + Fe(3+)(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23817", "l": "2-oxoglutarate + putrescine => 4-aminobutanal + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41060", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + octadecanoyl-CoA => 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-264458", "l": "Proteasome mediated degradation of COP1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697855", "l": "Superoxide and nitric oxide react to form peroxynitrite in mitochondria (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66827", "l": "2 ATP + 2 cob(II)inamide + 2 H2O + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)inamide + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198563", "l": "IDO1 dioxygenates L-Trp to NFK (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445714", "l": "Aquaporin-3 passively transports water out of cell (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17805", "l": "H2O + S-adenosyl-L-homocysteine = adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31009", "l": "beta-amyrin => (S)-2,3-epoxysqualene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20640", "l": "D-fructose + D-glucose <=> D-glucono-1,5-lactone + D-sorbitol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021523", "l": "WWP2 ubiquitinates NOTCH3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28719", "l": "adenine(in) + H(+)(in) = adenine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50742", "l": "glycine + leukotriene F4 => H2O + leukotriene C4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24870", "l": "5'-deoxyadenosine + phosphate => 5-deoxy-alpha-D-ribose 1-phosphate + adenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10052", "l": "(R)-2-hydroxy-4-methylpentanoate + NAD(+) = 4-methyl-2-oxopentanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61421", "l": "(S)-8-oxocitronellyl enol => cis-cis-nepetalactol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.72", "l": "\"Glycerol dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047750", "l": "cholestenol delta-isomerase activity"}, {"i": "RHEA:15281", "l": "5alpha-cholest-7-en-3beta-ol = 5alpha-cholest-8-en-3beta-ol"}, {"i": "EC:5.3.3.5", "l": "\"Cholestenol Delta-isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12486", "l": "a ribonucleoside + phosphate => a ribonucleoside 5'-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29789", "l": "ADP + glutathione(out) + H(+) + phosphate => ATP + glutathione(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39428", "l": "(2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH => (23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26223", "l": "abieta-7,13-dien-18-oate + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-ol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13731", "l": "AMP + H(+) + riboflavin cyclic-4',5'-phosphate => FAD"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43697", "l": "H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate => diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.3", "l": "\"Pyroglutamyl-peptidase I\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4341016", "l": "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59169", "l": "ATP + holo-[(hydroxy)phthioceranic acid synthase] + octadecanoate => AMP + diphosphate + octadecanoyl-[(hydroxy)phthioceranic acid synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15311", "l": "biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin] => (2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9692880", "l": "HRH3 binds Hist (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047735", "l": "cellobiose dehydrogenase (acceptor) activity"}, {"i": "RHEA:23484", "l": "A + D-cellobiose = AH2 + D-cellobiono-1,5-lactone"}, {"i": "EC:1.1.99.18", "l": "\"Cellobiose dehydrogenase (acceptor)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047200", "l": "tetrahydrodipicolinate N-acetyltransferase activity"}, {"i": "RHEA:13085", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O = CoA + L-2-acetamido-6-oxoheptanedioate"}, {"i": "EC:2.3.1.89", "l": "\"Tetrahydrodipicolinate N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8856951", "l": "PP2A demethylation by PPME1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11165", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine => 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35862", "l": "1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102593", "l": "UDP-glucose: N-methylanthranilate glucosyltransferase activity"}, {"i": "MetaCyc:RXN-15371"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65391", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O <=> a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10252", "l": "H(+) + hydrogen sulfide + O-phospho-L-serine = L-cysteine + phosphate"}, {"i": "EC:2.5.1.65", "l": "\"O-phosphoserine sulfhydrylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14436", "l": "a tRNA precursor + ATP + 2 CTP <=> a tRNA with a 3' CCA end + 3 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782943", "l": "UV-DDB ubiquitinates XPC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52174", "l": "11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35333", "l": "(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH => (S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47188", "l": "[Co(I) methylated-thiol-specific corrinoid protein] + methanethiol = [methyl-Co(III) methylated-thiol-specific corrinoid protein] + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22258", "l": "a 3-oxoacyl-CoA + H(+) + NADPH => a (3R)-3-hydroxyacyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11991", "l": "1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine <=> 1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211874", "l": "CYP2S1 4-hydroxylates atRA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2129357", "l": "Fibrillin C-terminal processing (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31200", "l": "(3S)-hydroxyoctanoyl-CoA => (2E)-octenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47499", "l": "lithocholate + NADP(+) <=> 3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32044", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate => 2 ATP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34653", "l": "3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + H(+) + S-adenosyl-L-homocysteine => 3-methyl-1,2-didehydro-2,3-dihydrosqualene + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17846", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) => 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-901047", "l": "Binding of ERp57 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805546", "l": "Keratin type I binds keratin type II (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351913", "l": "Caspase-mediated cleavage of TJP1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55450", "l": "a 3',5'-dihydroxyflavanone + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => a 3',5'-unsubstituted flavanone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29908", "l": "H2O + sn-glycero-3-phospho-(1'-rac-glycerol) => glycerol + H(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61345", "l": "H2O + L-serine + O2 => 3-hydroxypyruvate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62943", "l": "H2O + N(4)-acetylcytosine <=> acetate + cytosine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28075", "l": "(2R)-3-sulfopropanediol + H2O + 2 NAD(+) => (R)-3-sulfolactate + 3 H(+) + 2 NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25470", "l": "beta-himachalene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39266", "l": "(2E,13Z)-docosadienoyl-CoA + H(+) + NADPH <=> (13Z)-docosenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23524", "l": "1-O-(trans-cinnamoyl)-beta-D-glucose + an alcohol = an alkyl cinnamate + beta-D-glucose"}, {"i": "EC:2.3.1.152", "l": "\"Alcohol O-cinnamoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0016307", "l": "phosphatidylinositol phosphate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31422", "l": "(2Z,6E)-farnesyl diphosphate <=> (-)-beta-curcumene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39709", "l": "a long-chain fatty acyl-CoA(in) => a long-chain fatty acyl-CoA(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64539", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14323", "l": "H(+) + morphinone + NADPH => morphine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45494", "l": "(2R,3E)-phycocyanobilin + apo-[phycoerythrocyanin beta-subunit] => [phycoerythrocyanin beta-subunit]-Cys(84)-phycocyanobilin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170986", "l": "Ral-GDS binds to Ras-GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668417", "l": "cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19239", "l": "4-carboxymethyl-3-methylbut-2-en-1,4-olide => 4-carboxymethyl-4-methylbut-2-en-1,4-olide"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0003955", "l": "NAD(P)H dehydrogenase (quinone) activity"}, {"i": "MetaCyc:NQOR-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62736", "l": "1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + dimethylallyl diphosphate = 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61571", "l": "an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O <=> an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2464822", "l": "RDH12 reduces atRAL to atROL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052867", "l": "phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33284", "l": "2-hydroxycyclohexan-1-one + NADPH + O2 => 6-oxohexanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-190141", "l": "ALAD binds to Pb2+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2509838", "l": "ITPA hydrolyses dITP to dIMP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47474", "l": "(3E)-tetradecenoyl-CoA + NADP(+) => (2E,4E)-tetradecadienoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419426", "l": "Cannabinoid receptors can bind cannabinoids (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64458", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine => L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63696", "l": "SN-38 + UDP-alpha-D-glucuronate = H(+) + SN-38 O-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23888", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine = [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate"}, {"i": "EC:6.3.2.30", "l": "\"Cyanophycin synthase (L-arginine-adding)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.19"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58948", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine = 4-O-([3-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54041", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (3E,7E)-dolathalia-3,7,11-triene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38926", "l": "a ubiquinone + H(+) + Na(+)(in) + NADH <=> a ubiquinol + Na(+)(out) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46464", "l": "(24S)-25-epoxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S,25)-epoxy-7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29731", "l": "beta-maltose(in) = beta-maltose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16544", "l": "9-cis-violaxanthin + O2 <=> (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004699", "l": "calcium-independent protein kinase C activity"}, {"i": "REACT:R-HSA-5607740", "l": "PKC-delta phosphorylates CARD9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983147", "l": "Release of E3 from polyubiquitinated substrate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12442", "l": "2-oxoglutarate + H(+) + L-lysine + NADH => H2O + L-saccharopine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045522", "l": "interleukin-26 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034952", "l": "malonate semialdehyde decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24768", "l": "7(1)-hydroxychlorophyllide a + NAD(+) = chlorophyllide b + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43408", "l": "sphinganine + UDP-alpha-D-galactose = beta-D-galactosyl-(1<->1')-sphinganine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3772430", "l": "CTNNBIP1 binds beta-catenin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047885", "l": "farnesol 2-isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59572", "l": "H2O + L-homocarnosine = 4-aminobutanoate + L-histidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671829", "l": "JAK2 Phosphorylates STAT5 in Response to Leptin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17511", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+) => H2O + thiamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17543", "l": "an aromatic aldehyde + H2O2 => an aromatic primary alcohol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033445", "l": "AGU codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-481009", "l": "Exocytosis of platelet dense granule content (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684277", "l": "mRNA1 is translated to pp1ab (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928597", "l": "EPH:EFN dimers tetramerise (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685319", "l": "CX3 complex formation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8866277", "l": "AP-2 directly binds some endocytic cargo (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43820", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033416", "l": "UGG codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617820", "l": "Assembly of IFT B complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23704", "l": "GTP + 3 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 2 H(+)"}, {"i": "EC:3.5.4.25", "l": "\"GTP cyclohydrolase II\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805426", "l": "CARD8 binds CASP9(1-416) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49982", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine => H2O + hexanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001567", "l": "cholesterol 25-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56738", "l": "H(+) + H2O2 + retinoate => H2O + O2 + retinal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247840", "l": "WLS binds WNT ligands in the Golgi (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66850", "l": "2 Cu(+) + H(+) + NAD(+) => 2 Cu(2+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676589", "l": "RANKL,sRANKL trimer binds RANK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60123", "l": "(2E,6E)-farnesyl diphosphate + S-adenosyl-L-methionine <=> H(+) + pre-sodorifen diphosphate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685608", "l": "CLEC2B binds KLRF1 dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018520", "l": "cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase activity"}, {"i": "MetaCyc:1.3.1.67-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8858428", "l": "FCAMR binds IgA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167484", "l": "Fall Back to Closed Pre-initiation Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950741", "l": "IL12B:IL23A translocates from ER lumen to extracellular space (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2029454", "l": "Autophosphorylation of PAK1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937369", "l": "ATAD2 binds ESR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130504", "l": "Cleavage of lip22 to lip10 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696465", "l": "USP45 deubiquitinates ERCC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904769", "l": "isopentadecanoic acid binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019978", "l": "interleukin-3 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41137", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + choline + H(+) => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114284", "l": "Release of Cytochrome c from mitochondria (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66041", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192830", "l": "Viral Polymerase Assembly (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614591", "l": "Excess cysteine yields lanthionine and H2S (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56985", "l": "(2E,6E)-farnesyl diphosphate + H2O => (6E)-nerolidol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019807", "l": "aspartoacylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49154", "l": "dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + H(+) + S-adenosyl-L-homocysteine => dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694527", "l": "Loss of SAR1B GTPase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3777129", "l": "HDAC3 containing complexes deacetylate histone (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876484", "l": "NPC2 transfers CHOL to NPC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64109", "l": "H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56711", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657051", "l": "OGG1beta G12E does not translocate to mitochondria (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61362", "l": "ADP + H(+) + pheophorbide a(out) + phosphate => ATP + H2O + pheophorbide a(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62995", "l": "H2O + tetradecamide <=> NH4(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102258", "l": "1,3-diacylglycerol acylhydrolase activity"}, {"i": "MetaCyc:RXN-12433"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728752", "l": "TAS2R:bitter compound:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225949", "l": "Binding of CBL to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981621", "l": "Neuroglobin:oxygen dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445448", "l": "HHIP binds Hedgehog (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66342", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10469", "l": "D-xylulose 5-phosphate + phosphate => acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944218", "l": "Association of procollagen type VIII (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030768", "l": "16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578712", "l": "Importin-8 binds AGO2:miRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010181", "l": "FMN binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28937", "l": "oxaloacetate + pyruvate => 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46959", "l": "hydrocaffeoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> (E)-caffeoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111264", "l": "Addition of nucleotides between position +11 and +30 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46048", "l": "D-galactosamine 6-phosphate = alpha-D-galactosamine 1-phosphate"}, {"i": "EC:5.4.2.13", "l": "\"Phosphogalactosamine mutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66989", "l": "4-methylpentanoate + ATP + CoA => 4-methylpentanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.76", "l": "\"Arylalkyl acylamidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66050", "l": "(2S)-2-aminobutanoate + 4-(2-aminophenyl)-2,4-dioxobutanoate => 2-oxobutanoate + L-kynurenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52022", "l": "A + H2O + resolvin E2 => (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21781", "l": "A + cyclohexanone => AH2 + cyclohex-2-enone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944230", "l": "Association of procollagen type XVIII (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102639", "l": "paspalicine synthase activity"}, {"i": "MetaCyc:RXN-15737"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022871", "l": "protein-N(PI)-phosphohistidine-sorbose phosphotransferase system transporter activity"}, {"i": "RHEA:49296", "l": "keto-L-sorbose(out) + N(pros)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + L-sorbose 1-phosphate(in)"}, {"i": "EC:2.7.1.206", "l": "\"Protein-N(pi)-phosphohistidine--L-sorbose phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72691", "l": "Formation of the 43S pre-initiation complex (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47279", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140483", "l": "kinetochore adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36572", "l": "sphinganine + tetradecanoyl-CoA => CoA + H(+) + N-(tetradecanoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10051", "l": "methanethiol + O-acetyl-L-homoserine <=> acetate + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43844", "l": "(3beta)-hydroxy-cholest-5-en-26-al + NADPH + O2 = (3beta)-hydroxy-cholest-5-en-26-oate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.35", "l": "\"Phenol beta-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63531", "l": "[thioredoxin]-dithiol + H2O2 <=> [thioredoxin]-disulfide + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9615348", "l": "AGT(34-41) binds to AGTR2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59782", "l": "(2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine => L-histidine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25772", "l": "2-oxoglutarate + L-asparagine + O2 = (2S,3S)-3-hydroxyasparagine + CO2 + succinate"}, {"i": "EC:1.14.11.39", "l": "\"L-asparagine oxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24573", "l": "[(1->4)-alpha-D-glucosyl](n) + sucrose => [(1->4)-alpha-D-glucosyl](n+1) + D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58184", "l": "H(+) + NADPH + 2 phytyl diphosphate = (14E,18E)-lycopadiene + 2 diphosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046989", "l": "galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6794346", "l": "NRXNs bind NLGNs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5333671", "l": "CLCAs self cleave (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61449", "l": "H(+) + NADPH + O2 + tigecycline => 11a-hydroxytigecycline + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050416", "l": "formimidoylglutamate deiminase activity"}, {"i": "RHEA:22832", "l": "H2O + N-formimidoyl-L-glutamate = N-formyl-L-glutamate + NH4(+)"}, {"i": "EC:3.5.3.13", "l": "\"Formimidoylglutamate deiminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130619", "l": "TGN-lysosomal vesicle coat assembly (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018838", "l": "mandelate racemase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33266", "l": "L-phenylalanine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-phenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35432", "l": "1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside => 4-hydroxy-3-methoxybenzoate + cyanidin 3,7-di-O-beta-D-glucoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4411373", "l": "NLK translocates to nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46648", "l": "17-hydroxy-3-oxochol-4-en-22-oyl-CoA = androst-4-ene-3,17-dione + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4332363", "l": "Autophosphorylation and activation of CAMK2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52018", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36785", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine => L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23780", "l": "H2O + oxaloacetate + propanoyl-CoA = (2S,3S)-2-methylcitrate + CoA + H(+)"}, {"i": "EC:2.3.3.5", "l": "\"2-methylcitrate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109860", "l": "MAP2K1 phosphorylates MAPK3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71495", "l": "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033982", "l": "3-dehydro-L-gulonate-6-phosphate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047229", "l": "13-hydroxydocosanoate 13-beta-glucosyltransferase activity"}, {"i": "RHEA:22316", "l": "13-hydroxydocosanoate + UDP-alpha-D-glucose = 13-(beta-D-glucosyloxy)docosanoate + H(+) + UDP"}, {"i": "EC:2.4.1.158", "l": "\"13-hydroxydocosanoate 13-beta-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11552", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + H2O = 1-O-alkyl-sn-glycerol + acetate + H(+)"}, {"i": "EC:3.1.1.71", "l": "\"Acetylalkylglycerol acetylhydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32640", "l": "(6E)-8-hydroxylinalool + O2 + reduced [NADPH--hemoprotein reductase] => (6E)-8-oxolinalool + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34080", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + ADP + H(+) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56502", "l": "CO2 + isopentenyl phosphate + phosphate => (R)-3,5-bisphosphomevalonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25059", "l": "(E)-cinnamate + H(+) + NADH + O2 => (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59448", "l": "dodecan-1-ol + NADP(+) = dodecanal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30257", "l": "2 a ubiquinone + 2 H2O => 2 a ubiquinol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686578", "l": "Activated ATM phosphorylates ABL1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9680443", "l": "ROCK1,2 bind ROCKi (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10613", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-xylose => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-217255", "l": "FMO1:FAD N-oxidises TAM (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080048", "l": "GDP-D-glucose phosphorylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050306", "l": "sucrose 1F-fructosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64166", "l": "formaldehyde + L-alanine => 2-methyl-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53318", "l": "alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033149", "l": "FFAT motif binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48180", "l": "H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30432", "l": "(S)-2,3-epoxysqualene => taraxerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3296309", "l": "HCAR3 binds HCAR3 ligands (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429767", "l": "Passive I- efflux mediated by SMCT1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15228", "l": "alpha-D-glucose 1-phosphate + dTTP + H(+) <=> diphosphate + dTDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14790", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54067", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> 10-epi-cubebol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388605", "l": "POMC(138-176) binds MC2R (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990188", "l": "euchromatin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018808", "l": "RAC3 binds effectors at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50608", "l": "leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27475", "l": "ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+) => ATP + D-glycero-beta-D-manno-heptose 7-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49005", "l": "aurachin C + H(+) + NADPH + O2 => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34762", "l": "ATP + glycerol 2-phosphate(out) + H2O <=> ADP + glycerol 2-phosphate(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40710", "l": "(9Z,12Z,15Z)-octadecatrien-1-ol + 1-hexadecanoylglycerone 3-phosphate <=> 1-O-(9Z,12Z,15Z)-octadecatrienylglycerone 3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36374", "l": "(2S)-hydroxybutanoate + NAD(+) <=> 2-oxobutanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57046", "l": "3-oxoisoapionate + H(+) + NADH => D-apionate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32256", "l": "meso-2,6-diaminoheptanedioate + NADP(+) => (S)-2,3,4,5-tetrahydrodipicolinate + 2 H(+) + NADPH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56906", "l": "AMP + an acyl-CoA + H(+) => an acyl-AMP + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047254", "l": "2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity"}, {"i": "RHEA:15541", "l": "DIMBOA + UDP-alpha-D-glucose = DIMBOA beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24272", "l": "H(+) + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = H2O + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40885", "l": "(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + FADH2 => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448603", "l": "IL33:IL1RL1 binds IL1RAP-1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.171", "l": "\"Rhamnogalacturonan hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13276", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol <=> 6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48216", "l": "H(+) + hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375154", "l": "Interaction of NCAM1 with Major prion protein (PrP) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38735", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-hexadecanoylglycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694435", "l": "MIA2 and MIA3 load procollagen VII into COPII vesicles (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018237", "l": "urease activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22646", "l": "6-hydroxyprotopine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + protopine + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42974", "l": "a cardiolipin + ethanolamine => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020274", "l": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209160", "l": "Phosphorylated HOP phosphorylates DOME (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12469", "l": "avenacoside A + H2O => 26-desgluco-avenacoside A + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15360", "l": "5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose <=> demethyllactenocin + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102414", "l": "quercetin-3-O-glucoside 1,6-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-13797"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34135", "l": "cannabigerolate + O2 = Delta(9)-tetrahydrocannabinolate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1471322", "l": "Beta-defensins are secreted (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874079", "l": "PTK2 binds activated MET (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947541", "l": "Sulfhydrylation and ring cleavage of precursor Z (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0140312", "l": "cargo adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39771", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23296", "l": "N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate"}, {"i": "EC:4.1.3.3", "l": "\"N-acetylneuraminate lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035650", "l": "AP-1 adaptor complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022073", "l": "Procollagen triple helix formation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64234", "l": "atrochrysone carboxyl-[ACP] + 8 CO2 + 8 CoA + 2 H2O => 8 H(+) + holo-[ACP] + 8 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651789", "l": "LIG1 bound to POLB ligates SSB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43968", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5651789", "l": "LIG1 bound to POLB ligates SSB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019147", "l": "(R)-aminopropanol dehydrogenase activity"}, {"i": "RHEA:16517", "l": "(R)-1-aminopropan-2-ol + NAD(+) = aminoacetone + H(+) + NADH"}, {"i": "EC:1.1.1.75", "l": "\"(R)-aminopropanol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028583", "l": "Phosphorylation of YAP by LATS2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51327", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> (8R)-hydroperoxy-(9E,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18805", "l": "[DsbA protein]-disulfide + [protein]-dithiol = [DsbA protein]-dithiol + [protein]-disulfide"}, {"i": "EC:1.8.4.15", "l": "\"Protein dithiol oxidoreductase (disulfide-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23407", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate <=> diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017129", "l": "triglyceride binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38239", "l": "(9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA = 1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51934", "l": "2 [Fe(II)-cytochrome c3] + thiosulfate => 2 [Fe(III)-cytochrome c3] + hydrogen sulfide + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864029", "l": "PTPN12 dephosphorylates EGFR at Y1148 (Y1172) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187261", "l": "COLEC12 (SCARA4) binds ligands (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "66.785808001218697", "identifiers": [{"i": "GO:0015078", "l": "proton transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61209", "l": "8-nitro-cGMP + L-cysteinyl-[protein] => H(+) + nitrite + S-(guanosine 3',5'-cyclic phosphate)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350769", "l": "trans-Golgi Network Coat Activation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172194", "l": "Recruitment of PLK1 to phosphorylated GORASP1 (GRASP65) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21967", "l": "an acylcholine + H2O <=> a carboxylate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59646", "l": "D-xylobionate + H(+) => D-xylobiono-1,5-lactone + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038182", "l": "G protein-coupled bile acid receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16671", "l": "H(+) + NADH + urate => H2O + NAD(+) + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22054", "l": "AH2 + H(+) + hydroxylamine => A + H2O + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853429", "l": "PHLDA1 binds AURKA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373075", "l": "Metabotropic glutamate receptors bind glutamate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12822", "l": "2-deoxy-D-ribose 5-phosphate => acetaldehyde + D-glyceraldehyde 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60696", "l": "(R)-lavandulyl diphosphate + H2O = (R)-lavandulol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018656", "l": "phenanthrene 3,4-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47348", "l": "a butanoate ester + H2O = an aliphatic alcohol + butanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16092", "l": "H2O + phosphoethanolamine <=> ethanolamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.53", "l": "\"Endopeptidase La\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58570", "l": "CoA + O-acetyl-15alpha-stemmadenine => 15alpha-stemmadenine + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199456", "l": "PTEN dephosphorylates PIP3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707516", "l": "FeHM dissociates from MetHb (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50598", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H4] => acetyl-CoA + N-terminal L-seryl-[histone H4]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684071", "l": "RNF4 ubiquitinates MDC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21971", "l": "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate <=> 3-dehydroquinate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65181", "l": "AH2 + O2 + protoaustinoid B => A + H2O + preaustinoid A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35424", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose => an anthocyanidin 3,5-di-O-beta-D-glucoside + 2 H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112703", "l": "PTPN11 is phosphorylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033926", "l": "glycopeptide alpha-N-acetylgalactosaminidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26065", "l": "ATP + hygromycin B => 4-O-phosphohygromycin B + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41747", "l": "3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol <=> a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27899", "l": "3'-AMP + H2O => adenosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33619", "l": "ATP + CoA + tetradecanoate = AMP + diphosphate + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848818", "l": "PTK6 phosphorylates CBL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444100", "l": "PROT mediates L-proline uptake (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42615", "l": "a plastoquinone + (n+1) H(+)(in) + NADPH <=> a plastoquinol + n H(+)(out) + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19046", "l": "acetyl-CoA + H2O + pyruvate => (3R)-citramalate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23743", "l": "4-hydroxyphenylacetonitrile + H(+) + NADPH + O2 <=> 4-hydroxymandelonitrile + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53119", "l": "an 11beta-hydroxysteroid + NAD(+) <=> an 11-oxosteroid + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57538", "l": "5'-NTP-ribonucleotide-RNA + AMP + H(+) => a ribonucleoside 5'-triphosphate + adenosine-5'-diphospho-5'-ribonucleotide-RNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-422454", "l": "Polysialylation of NCAM1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55860", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2660819", "l": "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75081", "l": "Formation of AT-AC B Complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18707", "l": "a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810076", "l": "DDO oxidizes D-Asp to OA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58281", "l": "4 ATP => cyclic tetraadenylate + 4 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12477", "l": "H2O + N-formyl-L-glutamate => formate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755524", "l": "SUMOylation of NR1I2 with SUMO3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17781", "l": "H2O + N-formyl-L-methionine = formate + L-methionine"}, {"i": "EC:3.5.1.31", "l": "\"Formylmethionine deformylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473511", "l": "Collagen type XXIII binds Integrin alpha2beta1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5444523", "l": "Formation of MSH1:PMS2 Complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57847", "l": "fraxetin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sideretin (reduced form)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17086", "l": "4-pyridoxate + A => 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40910", "l": "2 2-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48465", "l": "ganglioside GM1b + H2O => ganglioside GA1 + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36720", "l": "hexacosenoyl-CoA + sphinganine => CoA + H(+) + N-hexacosenoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.30"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40009", "l": "(+)-copalol + diphosphate => (+)-copalyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47170", "l": "4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH => 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018756", "l": "RHOH binds GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59717", "l": "D-maltopentaono-1,5-lactone + H2O => D-maltopentaonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37712", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + acetyl-CoA => 1-O-(1Z)-alkenyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33558", "l": "an N-acyl-(4R)-4-hydroxysphinganine + H2O <=> (4R)-hydroxysphinganine + a fatty acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60916", "l": "a cytidine in mRNA + S-adenosyl-L-methionine = an N(3)-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981610", "l": "Neuroglobin binds oxygen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002952", "l": "(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877620", "l": "ECE2 cleaves EDN1(53-90) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950314", "l": "Expression of calponin-2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9630923", "l": "NFkB inhibitor binds NFkB complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17876", "l": "ATP + cob(III)alamin(out) + H2O <=> ADP + cob(III)alamin(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32334", "l": "(1S,2S,4R)-endo-fenchol + NAD(+) <=> (1S,4R)-fenchone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25616", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> terpentedienyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15155", "l": "4-(beta-D-glucosyloxy)benzoate + H(+) + UDP => 4-hydroxybenzoate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015194", "l": "L-serine transmembrane transporter activity"}, {"i": "REACT:R-HSA-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13063", "l": "glutathione S,S-dioxide + H(+) => O2 + S-sulfanylglutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14398", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) => (4Z)-2-oxohept-4-enedioate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382056", "l": "Crk binds to the active PDGF receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55280", "l": "13-cis-retinol + tetradecanoyl-CoA = 13-cis-retinyl tetradecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19336", "l": "H(+) + oxalyl-CoA <=> CO2 + formyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448702", "l": "Caspase-1 active tetramer formation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33083", "l": "dehypoxanthine futalosine + S-adenosyl-L-methionine = 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine"}, {"i": "EC:1.21.98.1", "l": "\"Cyclic dehypoxanthinyl futalosine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5246478", "l": "APOM binds retinoids (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37496", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11337", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine => deacetoxyvindoline + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47816", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-diphosphate + NADPH + O2 = 9-ribosyl-trans-zeatin 5'-diphosphate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18787", "l": "AH2 + gibberellin A12 + H(+) => A + gibberellin A12 aldehyde + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912629", "l": "CBL is tyrosine phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11785", "l": "H2O + L-aspartate + NADP(+) => H(+) + NADPH + NH4(+) + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195304", "l": "Association of beta-catenin with the destruction complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102868", "l": "24-epi-campsterol desaturase activity"}, {"i": "MetaCyc:RXN-8352"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13855", "l": "4-methylene-L-glutamine + AMP + diphosphate + H(+) => 4-methylene-L-glutamate + ATP + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611147", "l": "Endocytic Uptake of HCMV Virion (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35023", "l": "hydroquinone O-beta-D-glucopyranoside(out) = hydroquinone O-beta-D-glucopyranoside(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65831", "l": "H2O + neryl diphosphate <=> diphosphate + nerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25885", "l": "carbamoyl phosphate + N(2)-succinyl-L-ornithine => H(+) + N(2)-succinyl-L-citrulline + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24536", "l": "L-tryptophan + O2 = N-formyl-L-kynurenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9724685", "l": "IgE binds omalizumab (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374919", "l": "Noradrenaline clearance from the synaptic cleft (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047008", "l": "pregnan-21-ol dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791235", "l": "GADD45A binds AURKA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013889", "l": "TLR3-induced ripoptosome assembly (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30998", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoradiol <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + soyasapogenol B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68611", "l": "Formation of ORC(1-5) complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46788", "l": "a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(6Z,9Z,12Z,15Z)-octadectetraenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36670", "l": "(15Z)-tetracosenoyl-CoA + sphinganine <=> CoA + H(+) + N-(15Z-tetracosenoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1470009", "l": "Phosphorylation of STATs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "69.298854394597811", "identifiers": [{"i": "GO:1901505", "l": "carbohydrate derivative transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2482180", "l": "Collagen type VIII degradation by ELANE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373716", "l": "DCC interacting NCK-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72185", "l": "mRNA polyadenylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852552", "l": "MST1R autophosphorylates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805792", "l": "p-S291-PHF20 translocates to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22813", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) => 5,10-methenyltetrahydrofolate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53906", "l": "ADP + H(+) + O-phospho-L-threonyl-[tau protein] => ATP + L-threonyl-[tau protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40253", "l": "10-carboxy-13-deoxydaunorubicin + H(+) + methanol => 4-O-methylrhodomycin D + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016617", "l": "4-oxoproline reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54732", "l": "N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38277", "l": "acetyl-CoA + pyruvate => (3R)-citramalyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38669", "l": "sphing-4-enine 1-phosphate(out) => sphing-4-enine 1-phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612257", "l": "ADAP1 gene expression is inhibited by ERBB4s80 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29406", "l": "6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + AH2 + O2 <=> 3-demethylubiquinol-8 + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71303", "l": "RPE dimers isomerise RU5P to XY5P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13876", "l": "(+)-copalyl diphosphate <=> abieta-7,13-diene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60270", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-947514", "l": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9676160", "l": "AAMP binds NOD2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19867", "l": "4 CO2 + coproporphyrinogen III => 4 H(+) + uroporphyrinogen III"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202111", "l": "AKT1 phosphorylates eNOS (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046998", "l": "(S)-usnate reductase activity"}, {"i": "MetaCyc:1.1.1.199-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-481009", "l": "Exocytosis of platelet dense granule content (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429036", "l": "SLC2A9 transports Fru, Glc, urate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797974", "l": "LRRTMs bind NRXNs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209082", "l": "Further phosphorylation of APC by SGG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174731", "l": "Degradation of newly synthesized ApoB-48 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016230", "l": "sphingomyelin phosphodiesterase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50678", "l": "N-terminal L-aspartyl-[protein] + NH4(+) => H(+) + H2O + N-terminal L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374681", "l": "L1 and NCAM1 engaged in cis-interaction (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44651", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O <=> a 2-acyl-sn-glycerol 3-phosphate + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52130", "l": "AMP + 2 H(+) + phospho-5'-(DNA) => adenosine-5'-diphospho-5'-(DNA) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080023", "l": "3R-hydroxyacyl-CoA dehydratase activity"}, {"i": "REACT:R-HSA-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60624", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 H2O = 2 (9Z)-octadecenoate + 2 H(+) + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39013", "l": "a triacyl-sn-glycerol(out) => a triacyl-sn-glycerol(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47939", "l": "4-hydroxybenzaldehyde + H2O + NADP(+) <=> 4-hydroxybenzoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12705", "l": "[protein]-L-beta-isoaspartate + S-adenosyl-L-methionine = [protein]-L-beta-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.77", "l": "\"Protein-L-isoaspartate(D-aspartate) O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210282", "l": "Interaction of GPVI and FceRI gamma (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.5", "l": "\"Chondroitin AC lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848338", "l": "PNPLA4 hydrolyzes TAG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10359", "l": "3alpha-hydroxy-5beta-androstan-17-one + NAD(+) <=> 5beta-androstane-3,17-dione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694462", "l": "ABHD6,12 hydrolyse 3AG (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031767", "l": "gastric inhibitory polypeptide receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47840", "l": "[5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine = (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate"}, {"i": "EC:2.5.1.131", "l": "\"(4-(4-(2-(gamma-L-glutamylamino)ethyl)phenoxymethyl)furan-2-yl)methanamine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52292", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50088", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433606", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34849", "l": "5,6,7,8-tetrahydromonapterin + NADP(+) => 7,8-dihydromonapterin + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9632039", "l": "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322434", "l": "XIAP dissociates from ub-TLE (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139914", "l": "Translocation of BBC3 (PUMA) protein to mitochondria (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77077", "l": "Capping complex formation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10755", "l": "[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n ATP + n D-aspartate <=> [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n H(+) + n phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182988", "l": "Sprouty lures CBL away from EGFR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23748", "l": "ATP + GTP = diphosphate + pppGp(2'-5')A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730847", "l": "Hydrolysis of PIP2 by PLCG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647746", "l": "EML4 trimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41638", "l": "1-O-(1Z-alkenyl)-sn-glycerol + phosphate => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798044", "l": "BTG2 binds CCR4-NOT complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683467", "l": "CQ, HCQ are protonated to CQ2+, HCQ2+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32111", "l": "S-adenosyl-L-methionine + trans-resveratrol = 3-methoxy-4',5-dihydroxy-trans-stilbene + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30451", "l": "(S)-2,3-epoxysqualene = isomultiflorenol"}, {"i": "EC:5.4.99.36", "l": "\"Isomultiflorenol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36647", "l": "2-hydroxyhexadecanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxyhexadecanoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57752", "l": "2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH = C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)"}, {"i": "EC:2.3.1.292", "l": "\"(Phenol)carboxyphthiodiolenone synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389919", "l": "Grb2 binds pBTLA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38242", "l": "(9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA <=> 1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41855", "l": "H(+) + malonyl-[ACP] + octanoyl-[ACP] <=> 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047762", "l": "caffeate 3,4-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56328", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + H2O = 5'-triphosphoadenylyl-(2'->5')-adenosine + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1912357", "l": "ITCH ubiquitinates DTX (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:1901981", "l": "phosphatidylinositol phosphate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58899", "l": "4-hydroxybutanoate + ATP + CoA <=> 4-hydroxybutanoyl-CoA + ADP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51829", "l": "ATP(in) + CoA(in) + docosanoate(out) + H(+)(out) => AMP(in) + diphosphate(in) + docosanoyl-CoA(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420121", "l": "SFKs phosphorylate PLCG1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030973", "l": "molybdate ion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45041", "l": "2 [Fe(III)cytochrome c] + hydroxylamine => 2 [Fe(II)cytochrome c] + 2 H(+) + nitroxyl"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33401", "l": "L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in) => N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625674", "l": "Defective SLC22A5 does not cotransport CAR, Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2025890", "l": "Calcineurin binds NFATC1,2,3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51568", "l": "(25S)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25S)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507869", "l": "Aquaporins passively transport glycerol into cells (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392064", "l": "G alpha (z) inhibits adenylate cyclase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102816", "l": "UDP-D-glucose:delphinidin 3-O-glucosyl-5-O-caffeoylglucoside -O-beta-D-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33903", "l": "H2O + O2 + pseudooxynicotine = 4-oxo-4-(pyridin-3-yl)butanal + H2O2 + methylamine"}, {"i": "EC:1.4.3.24", "l": "\"Pseudooxynicotine oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64926", "l": "dAMP + 2 H(+) + 2 phosphate => dATP + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3204311", "l": "AOX1 oxidises PXL to PDXate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29988", "l": "adenosine(in) + H(+)(in) => adenosine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45615", "l": "H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052617", "l": "ent-kaur-16-en-19-al oxidase activity"}, {"i": "RHEA:10928", "l": "ent-kaur-16-en-19-al + O2 + reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54723", "l": "N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12653", "l": "(S)-malate + NAD(+) = CO2 + NADH + pyruvate"}, {"i": "EC:1.1.1.38", "l": "\"Malate dehydrogenase (oxaloacetate-decarboxylating)\""}, {"i": "EC:1.1.1.39", "l": "\"Malate dehydrogenase (decarboxylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981353", "l": "RASA1 stimulates RAS GTPase activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56015", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) <=> beta-D-mannose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25372", "l": "(2S)-2-amino-4-deoxychorismate + FMN => 3-(1-carboxyvinyloxy)anthranilate + FMNH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34642", "l": "1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 <=> H2O + NADP(+) + neopentalenolactone D"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49547", "l": "(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O <=> 2-dehydro-3-deoxy-D-gluconate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19070", "l": "(R)-S-lactoylglutathione => glutathione + methylglyoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41578", "l": "3-O-alpha-L-mycarosylerythronolide B + dTDP + H(+) => dTDP-beta-L-mycarose + erythronolide B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050469", "l": "sabinene-hydrate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956568", "l": "RUNX1 binds the core TAL1 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26047", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] = glyceollin II + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64382", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 3 AH2 => 3 A + phytyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49862", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65143", "l": "AH2 + O2 + protoaustinoid A <=> A + berkeleyone A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63349", "l": "ATP + L-amino acyl-L-cysteinyl-[protein] => (1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35387", "l": "precorrin-7 + S-adenosyl-L-methionine = 2 H(+) + precorrin-8X + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12164", "l": "3'-phosphoadenylyl sulfate + a phenol = a phenyl sulfate + adenosine 3',5'-bisphosphate + H(+)"}, {"i": "EC:2.8.2.1", "l": "\"Aryl sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46638", "l": "H(+) + NADPH + testosterone => 5beta-dihydrotestosterone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420243", "l": "GHRH receptor binds GHRH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39610", "l": "(2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H(+) + NADPH <=> (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29416", "l": "(S)-lactate(in) + H(+)(in) => (S)-lactate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36597", "l": "NADPH + sulfur => hydrogen sulfide + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17690", "l": "3'-phosphoadenylyl sulfate + glycochenodeoxycholate => adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112265", "l": "thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28077", "l": "(2R)-3-sulfopropanediol + H2O + 2 NAD(+) <=> (R)-3-sulfolactate + 3 H(+) + 2 NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41992", "l": "17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha-androstan-3,17-dione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031625", "l": "ubiquitin protein ligase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16785", "l": "an adenosine in tRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.55", "l": "\"tRNA (adenine-N(6)-)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32548", "l": "(2E)-geranyl diphosphate => (1R,5R)-sabinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202726", "l": "F11R dimerises (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21619", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203979", "l": "Coat Assembly (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54510", "l": "beta-heptaprene + diphosphate => all-trans-heptaprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696605", "l": "USP12, USP26 deubiquitinate AR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44546", "l": "a fatty acid(in) + ADP + H(+) + phosphate => a fatty acid(out) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35853", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61052", "l": "(-)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] = (-)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654224", "l": "Activated FGFR3 binds PLCG1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1254291", "l": "ERBB4s80 binds STAT5A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5138432", "l": "DVL2 is phosphorylated by PKC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.170", "l": "\"3-beta-hydroxysteroid-4-alpha-carboxylate 3-dehydrogenase (decarboxylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22825", "l": "2'-deoxyuridine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + uracil"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24522", "l": "(S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH => H2O + L-saccharopine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36407", "l": "ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate"}, {"i": "EC:2.7.7.87", "l": "\"L-threonylcarbamoyladenylate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981610", "l": "Neuroglobin binds oxygen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57804", "l": "1-chloro-3-nitrobenzene + NADH + O2 = 4-chlorocatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14032", "l": "A + H2O + selenite <=> AH2 + selenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2167917", "l": "SMAD7 binds to SMURF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23300", "l": "(2E)-geranyl diphosphate + isopentenyl diphosphate = (2Z,6E)-farnesyl diphosphate + diphosphate"}, {"i": "EC:2.5.1.68", "l": "\"(2Z,6E)-farnesyl diphosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41669", "l": "dihydrochelirubine + NADP(+) => chelirubine + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803527", "l": "ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26146", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + NADPH => 2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12568", "l": "4-nitrophenol + H(+) + NADH + O2 = 4-nitrocatechol + H2O + NAD(+)"}, {"i": "EC:1.14.13.29", "l": "\"4-nitrophenol 2-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35144", "l": "benzoyl-CoA + 2 H(+) + 3 malonyl-CoA => 2,4,6-trihydroxybenzophenone + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18970", "l": "a long-chain fatty acid + H(+) + hnu => a long-chain alkane + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47758", "l": "2'-O-methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37706", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65629", "l": "sphinga-(4E,8Z)-dienine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoylsphinga-(4E,8Z)-dienine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034560", "l": "bisphenol A hydroxylase A activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805276", "l": "CDK5 phosphorylates TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30590", "l": "2-demethylmenaquinol-8 + dimethyl sulfoxide <=> 2-demethylmenaquinone-8 + dimethyl sulfide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.40"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33836", "l": "H2O + N-hexacosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + hexacosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15315", "l": "acetaldehyde + NH4(+) => ethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0043236", "l": "laminin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3215406", "l": "PRMT5 binds WDR77 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29721", "l": "cob(I)alamin(out) => cob(I)alamin(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19470", "l": "NADH + 2 nitric oxide + 2 O2 => H(+) + NAD(+) + 2 nitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59413", "l": "2-oxosuccinamate + H2O => NH4(+) + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983426", "l": "Capturing cargo and formation of prebudding complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098618", "l": "selenomethionine-tRNA ligase activity"}, {"i": "REACT:R-HSA-2408546", "l": "tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17626", "l": "D-lysopine + H2O + NADP(+) => H(+) + L-lysine + NADPH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9015111", "l": "Factor Xa inhibitors binds Xa (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047616", "l": "acyl-CoA dehydrogenase (NADP+) activity"}, {"i": "RHEA:22460", "l": "a 2,3-saturated acyl-CoA + NADP(+) = a 2,3-dehydroacyl-CoA + H(+) + NADPH"}, {"i": "EC:1.3.1.8", "l": "\"Acyl-CoA dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5336443", "l": "LIN7, CASK and APBA1 bind (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22571", "l": "ascopyrone M <=> ascopyrone P"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.110"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40233", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 H2O + 2 oxidized [adrenodoxin] => (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534096", "l": "METAP1/2 demethylates GNAT1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37103", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O = (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52050", "l": "(9Z)-octadecenoate + 9-hydroxy-octadecanoate + H(+) => 9-(9Z-octadecenoyloxy)-octadecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43416", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18046", "l": "6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H2O => alpha-D-glucose 1-phosphate + alpha-D-mannose derivative + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15420", "l": "L-arogenate + NADP(+) <=> CO2 + L-tyrosine + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33629", "l": "AMP + decanoyl-CoA + diphosphate => ATP + CoA + decanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17807", "l": "adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine => H2O + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33216", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 3 isopentenyl diphosphate => all-trans-heptaprenyl diphosphate + 3 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725206", "l": "IgE binds FCERI (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40084", "l": "hexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 26-hydroxyhexacosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36424", "l": "2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27415", "l": "CO2 + formaldehyde + morphine + succinate => 2-oxoglutarate + codeine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16656", "l": "D-gluconate + NADP(+) <=> 2-dehydro-D-gluconate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48270", "l": "canthaxanthin + H2O => 4',4'-dihydroxyechinenone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48012", "l": "4-methyl-5-nitrocatechol + NADPH + O2 = 2-hydroxy-5-methylquinone + H(+) + H2O + NADP(+) + nitrite"}, {"i": "RHEA:48016", "l": "4-methyl-5-nitrocatechol + NADH + O2 = 2-hydroxy-5-methylquinone + H(+) + H2O + NAD(+) + nitrite"}, {"i": "EC:1.14.13.210", "l": "\"4-methyl-5-nitrocatechol 5-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071858", "l": "corazonin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004350", "l": "glutamate-5-semialdehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5223313", "l": "ABCD4:LMBRD1 transports Cbl from lysosomal lumen to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44940", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + H2O = 1-O-alkyl-3-acyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701507", "l": "PTPN6 dephosphorylates JAK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6794346", "l": "NRXNs bind NLGNs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30171", "l": "hexadecanoyl-[ACP] + sn-glycerol 3-phosphate = 1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30715", "l": "(2E)-geraniol = (S)-linalool"}, {"i": "EC:5.4.4.4", "l": "\"Geraniol isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11468", "l": "(S)-3-methyl-2-oxopentanoate + L-valine = 3-methyl-2-oxobutanoate + L-isoleucine"}, {"i": "EC:2.6.1.32", "l": "\"Valine--3-methyl-2-oxovalerate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189406", "l": "4 PBGs bind to form HMB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35268", "l": "ethanol(in) => ethanol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161775", "l": "ALOX12 oxidises LTA4 to LXA4/B4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42723", "l": "S-adenosyl-L-methionine + uridine(2552) in 23S rRNA <=> 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42429", "l": "clavaminate => (3R,5R)-clavulanate-9-aldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693250", "l": "RHOD binds effectors at the Golgi membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38997", "l": "a 1-acyl-sn-glycero-3-phosphate + choline + H(+) => a 1-acyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43693", "l": "ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] => AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52969", "l": "hyocholate + UDP-alpha-D-glucuronate => H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29523", "l": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+)"}, {"i": "EC:2.4.1.131", "l": "\"GDP-Man:Man(3)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47299", "l": "dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170964", "l": "FRS2 binds to active TrkA receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848829", "l": "CBL autoubiquitinates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018477", "l": "benzaldehyde dehydrogenase (NADP+) activity"}, {"i": "RHEA:21660", "l": "benzaldehyde + H2O + NADP(+) = benzoate + 2 H(+) + NADPH"}, {"i": "EC:1.2.1.7", "l": "\"Benzaldehyde dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26066", "l": "4-O-phosphohygromycin B + ADP + H(+) => ATP + hygromycin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20660", "l": "4-chlorophenylacetonitrile + 2 H2O <=> 4-chlorophenylacetate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626223", "l": "C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28528", "l": "(R)-carnitinyl-CoA + crotonobetaine => (R)-carnitine + crotonobetainyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43278", "l": "ganglioside GalNAc-GD1a + H(+) + UDP => ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008696", "l": "IL37(?-218) translocates from the cytosol to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362551", "l": "Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66063", "l": "2-oxohexanoate + L-kynurenine <=> H2O + kynurenate + L-2-aminohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57511", "l": "H2O + NADP(+) + staphylopine <=> (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3296233", "l": "T2Rs bind bitter-tasting compounds (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "78.047734625335977", "identifiers": [{"i": "GO:0070568", "l": "guanylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8873794", "l": "PCTP binds PC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247836", "l": "Retromer recycles WLS to the Golgi (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33149", "l": "ADP + daunorubicin(out) + H(+) + phosphate => ATP + daunorubicin(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5323526", "l": "FRAT proteins bind GSK3beta (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676599", "l": "sBAFF trimer binds BAFFR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51362", "l": "(9Z)-octadecenoate + L-leucine => H2O + N-(9Z-octadecenoyl)-L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15451", "l": "4-maleylacetoacetate + H(+) => homogentisate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50424", "l": "(8Z,11Z,14Z)-eicosatrienoate + 2 O2 = prostaglandin G1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51673", "l": "glyoxal + H2O => glycolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016501", "l": "prostacyclin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30176", "l": "15-cis-phytoene + 2 plastoquinone-9 => 9,9',15-tri-cis-zeta-carotene + 2 plastoquinol-9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60380", "l": "L-dehydroascorbate(out) = L-dehydroascorbate(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033889", "l": "N-sulfoglucosamine-3-sulfatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982617", "l": "CYGB:O2 dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061776", "l": "topological DNA co-entrapment activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353323", "l": "Ligation of newly synthesized repair patch to incised DNA in GG-NER (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16263", "l": "CoA + H(+) + N(6)-succinyl-L-lysyl-[protein] => L-lysyl-[protein] + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8931981", "l": "RUNX1 binds ESR1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63473", "l": "all-trans-hexaprenol + ATP => ADP + all-trans-hexaprenyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49902", "l": "H2O2 + phenazine-1,6-dicarboxylate => 5,10-dihydrophenazine-1,6-dicarboxylate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32519", "l": "(2E)-geranyl diphosphate + S-adenosyl-L-methionine = (E)-2-methylgeranyl diphosphate + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.255", "l": "\"Geranyl diphosphate 2-C-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30801", "l": "acetoacetyl-CoA + H(+) + NADH => (3S)-3-hydroxybutanoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416690", "l": "SEMA4A binds to PLXND1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72672", "l": "The 60S subunit joins the translation initiation complex  (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2974737", "l": "NOTCH2 binds MDK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44279", "l": "eicosanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(2-oxohenicosyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38502", "l": "a triacyl-sn-glycerol + H2O <=> a 2,3-diacyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46594", "l": "calcitriol + H2O + 2 oxidized [adrenodoxin] => alfacalcidol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.15", "l": "\"D-glutamate(D-aspartate) oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36321", "l": "CoA + 2 NADP(+) + octadecan-1-ol => 2 H(+) + 2 NADPH + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44025", "l": "(3R)-3-hydroxydodecanoyl-CoA => (2E)-dodecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700154", "l": "Active ALK binds SHC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61490", "l": "5-methylcytidine(50) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(50) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10265", "l": "alpha-D-glucose => beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852306", "l": "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65056", "l": "glycochenodeoxycholate + NADP(+) = 7-oxoglycolithocholate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19097", "l": "AH2 + 2 ATP + benzoyl-CoA + 2 H2O = A + 2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51298", "l": "a quinol + L-methionyl-(R)-S-oxide-[protein] => a quinone + H2O + L-methionyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210277", "l": "Interaction of PECAM-1 and SHP-1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018642", "l": "chlorophenol 4-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37133", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13538", "l": "(2R)-3-phosphoglycerate + GDP-alpha-D-mannose => 2-O-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0015343", "l": "siderophore transmembrane transporter activity"}, {"i": "REACT:R-HSA-1222597", "l": "Loaded mycobactin gets imported (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33210", "l": "ATP + H(+) + L-glutamate + NADPH <=> ADP + L-glutamate 5-semialdehyde + NADP(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41286", "l": "H2O + N-tetracosanoyl-sphing-4-enine <=> sphing-4-enine + tetracosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390112", "l": "Phosphorylated HPO dimer phosphorylates WTS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928641", "l": "PAK binds RAC and bPIX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379992", "l": "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047121", "l": "isoquinoline 1-oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014812", "l": "ROBOs bind keratan sulfate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32015", "l": "(2E,6E)-farnesyl diphosphate = (-)-delta-cadinene + diphosphate"}, {"i": "EC:4.2.3.97", "l": "\"(-)-delta-cadinene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.67", "l": "\"Choriolysin H\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41262", "l": "L-tryptophan <=> (E)-3-(indol-3-yl)acrylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42252", "l": "H(+) + malonyl-[ACP] + pentanoyl-CoA = 3-oxoheptanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70420", "l": "HK1,2,3,GCK phosphorylate Glc to form G6P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.66"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53722", "l": "ADP + H(+) + N-acetyl-alpha-D-muramate 1-phosphate => ATP + N-acetyl-D-muramate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65546", "l": "an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-D-Glc => ganglioside GM1 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156661", "l": "Formation of Exon Junction Complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-532549", "l": "MPI isomerises Fru6P to Man6P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "65.423565948422279", "identifiers": [{"i": "GO:0016817", "l": "hydrolase activity, acting on acid anhydrides"}, {"i": "EC:3.6.-.-", "l": "\"Acting on acid anhydrides\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42675", "l": "hercynine + L-gamma-glutamyl-L-cysteine + O2 <=> H2O + L-gamma-glutamyl-hercynylcysteine S-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25958", "l": "3-dehydroquinate + H(+) + NADH + NH4(+) => 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418662", "l": "Src activation following P2Y purinoceptor activation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50655", "l": "2-(3-methylsulfanyl)propylmalate <=> 2-(2-methylsulfanyl)propylmaleate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168412", "l": "MDP elicits a NOD2 response (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016483", "l": "tryptophan hydroxylase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43099", "l": "guanosine(2535) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(2535) in 23S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168857", "l": "Binding of vRNP:M1:NEP complex to CRM1 export receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45062", "l": "(9Z)-octadecenoate + ethanolamine => H2O + N-(9Z-octadecenoyl) ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5138459", "l": "WNT5A:FZD4 is endocytosed (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50883", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-glycerol <=> 4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57382", "l": "(13S,14R)-1,13-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34082", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + ADP + H(+) <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + ATP"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0005242", "l": "inward rectifier potassium channel activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003835", "l": "beta-galactoside alpha-2,6-sialyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35154", "l": "4-hydroxy-3-nitrophenylacetaldehyde + H2O + NAD(+) <=> (3-nitro-4-oxidophenyl)acetate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19530", "l": "isovitexin + UDP-alpha-D-glucose => H(+) + isovitexin 2''-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444527", "l": "FPR is a receptor for formyl peptides (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30784", "l": "D-glyceraldehyde + H2O + NAD(+) => (R)-glycerate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48409", "l": "apo-[EntF peptidyl-carrier protein] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[EntF peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2473584", "l": "Collagen type III degradation by MMP15 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62223", "l": "phyllostine <=> neopatulin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56624", "l": "2,4,5-trichlorocyclohexa-2,5-dien-1-ol + H2O = 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + chloride + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034873", "l": "thioacetamide S-oxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-481007", "l": "Exocytosis of platelet alpha granule contents (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "75.582117822819498", "identifiers": [{"i": "GO:0004812", "l": "aminoacyl-tRNA ligase activity"}, {"i": "EC:6.1.1.-", "l": "\"Ligases forming aminoacyl-tRNA and related compounds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211874", "l": "CYP2S1 4-hydroxylates atRA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41055", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + dodecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-dodecanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31551", "l": "presqualene diphosphate = 15-cis-4,4'-diapophytoene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209921", "l": "Monoiodinated tyrosine can be deiodinated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013110", "l": "RHOC binds effectors at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850831", "l": "KLK5 cleaves and activates KLK8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.n4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102501", "l": "D-fructuronate reductase activity"}, {"i": "MetaCyc:RXN-14368"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16017", "l": "2-oxoglutarate + L-ornithine = 5-amino-2-oxopentanoate + L-glutamate"}, {"i": "EC:2.6.1.8", "l": "\"2,5-diaminovalerate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390649", "l": "CHRM1,3,5 bind acetylcholine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28046", "l": "phosphate + propanoyl-CoA = CoA + propanoyl phosphate"}, {"i": "EC:2.3.1.222", "l": "\"Phosphate propanoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2186780", "l": "Degradation of Ub-SMAD7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1671687", "l": "PRLR activation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0016906", "l": "sterol 3-beta-glucosyltransferase activity"}, {"i": "RHEA:22724", "l": "a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + H(+) + UDP"}, {"i": "EC:2.4.1.173", "l": "\"Sterol 3-beta-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33693", "l": "(S)-2-ethyl-2-hydroxy-3-oxobutanoate + thiamine diphosphate => 2-(1-hydroxyethyl)thiamine diphosphate + 2-oxobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36641", "l": "3-O-methylphospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-homocysteine => 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682983", "l": "ATM phosphorylates WHSC1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50084", "l": "ATP + H2O + taurolithocholate 3-sulfate(in) = ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32333", "l": "(1S,4R)-fenchone + H(+) + NADH => (1S,2S,4R)-endo-fenchol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209925", "l": "DIT and MIT combine to form triiodothyronine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008951", "l": "palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity"}, {"i": "RHEA:44012", "l": "(9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA = (9Z)-hexadecenoyl-(Kdo)2-lipid IVA + holo-[ACP]"}, {"i": "MetaCyc:PALMITOTRANS-RXN"}, {"i": "EC:2.3.1.242", "l": "\"Kdo(2)-lipid IV(A) palmitoleoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466846", "l": "atRAL can spontaneously react with PE to form NRPE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49552", "l": "H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] = H(+) + L-lysyl-[protein] + lactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.-", "l": "\"Phosphotransferases with regeneration of donors, apparently catalyzing intramolecular transfers\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40824", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38738", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-hexadecanoylglycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45467", "l": "2 [Fe(II)-cytochrome b5] + eicosanoyl-CoA + 2 H(+) + O2 <=> (5Z)-eicosenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004906", "l": "interferon-gamma receptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050547", "l": "vanillin synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15348", "l": "ATP + L-arginine + L-tyrosine <=> AMP + diphosphate + H(+) + L-tyrosyl-L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420019", "l": "Claudins create paired strands through homophilic and heterophilic cis and trans interactions (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103093", "l": "methylthioalkylmalate dehydrogenase activity"}, {"i": "MetaCyc:RXNQT-4178"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176956", "l": "Formation of GINS complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050100", "l": "methylitaconate delta-isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669024", "l": "CD70 binds CD27 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191654", "l": "c-src associates with Cx43 in gap junctions (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43531", "l": "L-serine + NAD(+) <=> 2-aminomalonate semialdehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047780", "l": "citrate dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051537", "l": "2 iron, 2 sulfur cluster binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48861", "l": "18-HEPE + O2 => (5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607004", "l": "Soluble PROCR binds PRTN3:CD177 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55945", "l": "2-chloroethanol + 2 [Fe(III)cytochrome c] => 2 [Fe(II)cytochrome c] + chloroacetaldehyde + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694572", "l": "3a localizes to the cell membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43998", "l": "a 2-hydroxy-3-methyl fatty acyl-CoA + CO2 + succinate => 2-oxoglutarate + a 3-methyl fatty acyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66636", "l": "(2E,6E)-farnesyl diphosphate + H2O = (-)-alpha-acorenol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730851", "l": "Phosphorylation of SLP-76 by p-SYK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3899291", "l": "SUMOylation of EP300 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247847", "l": "WLS is endocytosed to the early endosome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13920", "l": "(-)-menthol + NADP(+) <=> (1R,4S)-menthone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52868", "l": "17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29057", "l": "a ubiquinol + 2 H(+)(out) => a ubiquinone + 2 H(+)(in) + H2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873927", "l": "Release of STAT1 dimer from active receptor unit (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351913", "l": "Caspase-mediated cleavage of TJP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42765", "l": "formate + 2 H(+) + oxidized coenzyme F420-(gamma-Glu)(n) => CO2 + reduced coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22254", "l": "globoside Gb4Cer (d18:1(4E)) + H(+) + UDP => globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848606", "l": "PTK6 phosphorylates PXN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193996", "l": "11DCORST translocates from cytosol to mitochondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9035227", "l": "TXN2 binds CysS248-MPST (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851011", "l": "TRIM27 polyubiquitinates PTEN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15816", "l": "1H-imidazole + acetyl-CoA <=> CoA + N-acetylimidazole"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53164", "l": "H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "75.848614326174683", "identifiers": [{"i": "GO:0019829", "l": "ATPase-coupled cation transmembrane transporter activity"}, {"i": "REACT:R-HSA-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Homo sapiens)"}, {"i": "REACT:R-HSA-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70592", "l": "PXLP-K259-GOT1 dimer deaminates L-Asp (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322427", "l": "Beta-catenin recruits CBP/p300 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903231", "l": "mRNA binding involved in posttranscriptional gene silencing"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-622310", "l": "Activated NOD1 oligomerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358519", "l": "MSH2:MSH3 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46152", "l": "15-cis-phytoene + a plastoquinone = 15,9'-di-cis-phytofluene + a plastoquinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954082", "l": "E2F6 binds the PRC1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202453", "l": "Auto-ubiquitination of TRAF6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58688", "l": "NADH + O2 + rifamycin SV = H2O + NAD(+) + rifamycin SV para-naphthoquinone carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482778", "l": "CL is hydrolyzed to MLCL by PLA2G6 (IM) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26105", "l": "homocitrate = cis-homoaconitate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17227", "l": "6-hydroxynicotinate + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => 1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9604308", "l": "NICD4 traffics to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24905", "l": "cyclic di-3',5'-guanylate + H2O <=> 5'-phosphoguanylyl(3'->5')guanosine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984733", "l": "Kinesin-3 is a dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55435", "l": "11-hydroxyferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> carnosate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042007", "l": "interleukin-18 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950782", "l": "p-STAT1 binds p-STAT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58313", "l": "25-substituted-cholesteryl beta-D-glucoside + H2O => 25-substituted-cholesterol + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9653514", "l": "USP17L2 deubiquitinates RCE1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32405", "l": "(1R,4R)-dihydrocarvone + H(+) + NADH => (1R,2S,4R)-neodihydrocarveol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4395227", "l": "CCND1:CREBBP binds NOTCH1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13107", "l": "glycerol + phosphate => glycerol 2-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689085", "l": "ATXN3 binds polyUb-PARK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25399", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate"}, {"i": "EC:5.4.4.6", "l": "\"9,12-octadecadienoate 8-hydroperoxide 8S-isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32446", "l": "all-trans-zeaxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40481", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3159253", "l": "MMAB transfers adenosyl group from ATP to cob(I)alamin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14641", "l": "cyanurate + H2O = biuret + CO2"}, {"i": "EC:3.5.2.15", "l": "\"Cyanuric acid amidohydrolase\""}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0016856", "l": "racemase and epimerase activity, acting on hydroxy acids and derivatives"}, {"i": "EC:5.1.2.-", "l": "\"Acting on hydroxy acids and derivatives\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036505", "l": "prosaposin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58145", "l": "acetate + ATP + cytidine(34) in elongator tRNA(Met) => AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18393", "l": "(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine"}, {"i": "EC:2.6.1.40", "l": "\"(R)-3-amino-2-methylpropionate--pyruvate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50003", "l": "butane + H(+) + NADH + O2 <=> butan-1-ol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40639", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37104", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O => (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209823", "l": "Tyrosine is hydroxylated to dopa (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25816", "l": "H2O + norspermine + O2 = 3-aminopropanal + H2O2 + norspermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15923", "l": "a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a 1,2-diacyl-sn-glycerol => 2 a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55115", "l": "4-methyl-3-oxopentanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-4-methylpentanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61356", "l": "ATP + H2O + methotrexate(in) = ADP + H(+) + methotrexate(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429860", "l": "DCP1-DCP2 complex decaps mRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18679", "l": "[Fe(II)-cytochrome b5] + H(+) + monodehydro-L-ascorbate radical => [Fe(III)-cytochrome b5] + L-ascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2002440", "l": "Removal of fibrillar collagen C-propeptides (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266303", "l": "Spherical HDL binds C and E apolipoproteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36970", "l": "(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57244", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP = dGTP + H(+) + lactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697057", "l": "esxG binds esxH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12033", "l": "a 3-(acyloxy)acyl derivative of bacterial toxin + H2O => 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32678", "l": "alpha,alpha-trehalose + H2O <=> alpha-D-glucose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483089", "l": "PE is converted to PS by PTDSS2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45159", "l": "3-oxopropanoyl-CoA + H2O <=> 3-oxopropanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047051", "l": "D-lactate dehydrogenase (cytochrome c-553) activity"}, {"i": "MetaCyc:1.1.2.5-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23925", "l": "pppGp(2'-5')A => 2',3'-cGAMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950210", "l": "Interleukin-27 dissociates from Interleukin-27 receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917700", "l": "MVB Vesicle Formation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34914", "l": "D-methionine(in) <=> D-methionine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15619", "l": "[Fe(III)cytochrome c] + Fe(2+) => [Fe(II)cytochrome c] + Fe(3+)"}]}
{"type": "biolink:MolecularActivity", "ic": "78.047734625335977", "identifiers": [{"i": "GO:0120013", "l": "lipid transfer activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174731", "l": "Degradation of newly synthesized ApoB-48 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25109", "l": "ATP + pyridoxine => ADP + H(+) + pyridoxine 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684018", "l": "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202216", "l": "Phosphorylation of SLP-76 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12142", "l": "a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+) => a 2'-deoxyribonucleoside + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791327", "l": "TP53 binds the BCL2L14 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54782", "l": "[LarE protein]-dehydroalanine + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide => [LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666425", "l": "p-6Y-SYK phosphorylates VAV1,2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786567", "l": "KIAA1456 (TRM9L) methylates 5-carboxymethyluridine in tRNA yielding 5-methoxycarbonylmethyluridine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29304", "l": "2 H(+)(in) + succinate(in) => 2 H(+)(out) + succinate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334788", "l": "CUTC binds Cu+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12995", "l": "cyclohexa-1,5-diene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein] => cyclohex-1-ene-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52094", "l": "(9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H(+) => 5-(9Z-hexadecenoyloxy)-octadecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624120", "l": "CEBPA binds CDK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77589", "l": "Recognition of AAUAAA sequence by CPSF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34050", "l": "6'''-deamino-6'''-hydroxyneomycin C + O2 <=> 6'''-deamino-6'''-oxoneomycin C + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37822", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-947514", "l": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36615", "l": "2-hydroxyoctadecanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxyoctadecanoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904713", "l": "beta-catenin destruction complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65425", "l": "AMP(in) + NAD(+)(out) => AMP(out) + NAD(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018629", "l": "2-hydroxyquinoline 5,6-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25264", "l": "2-hydroxyglutarate + FAD + H(+) <=> 2-oxoglutarate + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32451", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate = all-trans-phytoene + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44576", "l": "4-hydroxy-3-all-trans-nonaprenylbenzoate + H(+) = 2-all-trans-nonaprenylphenol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60686", "l": "(11R)-dihydroartemisinate + 2 H(+) + NADPH => (11R)-dihydroartemisinic aldehyde + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0032182", "l": "ubiquitin-like protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24053", "l": "a ubiquinone + reduced [electron-transfer flavoprotein] => a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8863718", "l": "AGFG1 binds VAMP7 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21247", "l": "an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine <=> an 8-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13603", "l": "4-oxo-L-proline + H(+) + NADH => 4-hydroxy-L-proline + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0050492", "l": "glycerol-1-phosphate dehydrogenase [NAD(P)+] activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47270", "l": "H2O + monoanhydrobacterioruberin => bacterioruberin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55304", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41006", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6795290", "l": "TORC2 complex phosphorylates SGK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103092", "l": "methylthioalkylmalate isomerase activity"}, {"i": "MetaCyc:RXNQT-4176"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139952", "l": "Caspase-8 processing in the DISC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40366", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47593", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) => CMP + ganglioside GP1c (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33862", "l": "(2S-3S)-versiconal hemiacetal <=> H2O + versicolorin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170159", "l": "Translocation of Cdc25 to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44455", "l": "3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18615", "l": "4-hydroxybenzoate + A + formaldehyde + H2O => 4-methoxybenzoate + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9681375", "l": "KIT binds ripretinib (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0030696", "l": "tRNA (m5U54) methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043784", "l": "cob(II)yrinic acid a,c-diamide reductase activity"}, {"i": "EC:1.16.8.1", "l": "\"Cob(II)yrinic acid a,c-diamide reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15395", "l": "meso-2,6-diaminoheptanedioate => (2S,6S)-2,6-diaminoheptanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20704", "l": "a D-alpha-amino acid + acetyl-CoA = an N-acetyl-D-amino acid + CoA + H(+)"}, {"i": "EC:2.3.1.36", "l": "\"D-amino-acid N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52019", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA <=> 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52741", "l": "glyphosate + H2O + O2 => aminomethylphosphonate + glyoxylate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29459", "l": "beta-alanine(in) + H(+)(in) = beta-alanine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30362", "l": "chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2 <=> chlorophyllide b + 3 H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47086", "l": "3-(4-hydroxyphenyl)pyruvate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46826", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805205", "l": "GPR35 binds kynurenic acid (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24233", "l": "2-dehydro-3-deoxy-D-gluconate + NAD(+) => 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29246", "l": "H(+) + menaquinone-8 + NADH <=> menaquinol-8 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33876", "l": "cholesteryl (9Z-octadecenoate) + H2O => (9Z)-octadecenoate + cholesterol + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061686", "l": "hercynylcysteine sulfoxide synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19700", "l": "11-cis-retinyl hexadecanoate + H2O <=> 11-cis-retinol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202174", "l": "Activation of ZAP-70 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0008235", "l": "metalloexopeptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22532", "l": "(2E)-octenedioyl-CoA + H2O = (3S)-hydroxyoctanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75172", "l": "Formation of RAD50:MRE11 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086037", "l": "P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018747", "l": "RHOQ GEFs activate RHOQ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27315", "l": "dichlorochromopyrrolate + 6 H(+) + 4 NADH + 4 O2 => 2 CO2 + dichloroarcyriaflavin A + 6 H2O + 4 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857686", "l": "FITM1, FITM2 bind TAGs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655170", "l": "RCHY1 monoubiquitinates POLH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16738", "l": "H(+) + NADH + O2 + toluene => (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60931", "l": "(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 17-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45044", "l": "2 [Fe(II)cytochrome c] + H(+) + nitroxyl + O2 = 2 [Fe(III)cytochrome c] + H2O + nitrite"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102792", "l": "sinapaldehyde:NAD(P)+ oxidoreductase activity"}, {"i": "MetaCyc:RXN-8014"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863727", "l": "STON2 is neddylated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20260", "l": "3-methyloxindole + NADP(+) <=> 3-methyleneoxindole + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10925", "l": "cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide => trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848335", "l": "IL37 binds  IL18R1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13082", "l": "biotin amide + H2O => biotin + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661425", "l": "BIL:ALB dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791184", "l": "Expression of ATP6VOD1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685156", "l": "ATR phosphorylates RPA2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625421", "l": "The anterograde IFT train dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30845", "l": "formate + H(+) + maleamate => H2O + N-formylmaleamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57838", "l": "3-aminopropanal + H2O2 + spermidine => H2O + O2 + thermospermine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805546", "l": "Keratin type I binds keratin type II (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388809", "l": "CTLA-4 binds B7-1/B7-2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874718", "l": "TTPA binds alpha-TOH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49781", "l": "docosanoyl-CoA + glycine => CoA + H(+) + N-docosanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48761", "l": "L-threitol + NAD(+) => H(+) + L-erythrulose + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46146", "l": "(24R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32894", "l": "(1S,5S)-alpha-pinene + H(+) + NADH + O2 <=> alpha-pinene oxide + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11110", "l": "n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+) => n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61615", "l": "2-oxoglutarate + 7-deoxycylindrospermopsin + O2 <=> 7-epi-cylindrospermopsin + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983424", "l": "Budding of COPII coated vesicle (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30260", "l": "2 a menaquinol + O2 => 2 a menaquinone + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43882", "l": "3beta-hydroxy-5-cholestenoyl-CoA + AMP + diphosphate => 3beta-hydroxy-5-cholestenoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112429", "l": "Formation of FACT complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22508", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44769", "l": "3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) => 2-methoxy-6-(all-trans-hexaprenyl)phenol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18239", "l": "3-maleylpyruvate + H(+) => 2,5-dihydroxybenzoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0019841", "l": "retinol binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014433", "l": "RHOG GEFs activate RHOG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8986083", "l": "USP33 deubiquitinates ROBO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14508", "l": "2 glutathione + thiosulfate <=> glutathione disulfide + 2 H(+) + hydrogen sulfide + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58072", "l": "a 4,5-didehydrojasmonate + H(+) + NADPH = a jasmonate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20592", "l": "glutaryl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19946", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16686", "l": "di-trans,poly-cis-dolichol + hexadecanoyl-CoA => CoA + dolichyl hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106059", "l": "tRNA (cytidine 56-2'-O)-methyltransferase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.n3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139899", "l": "Sequestration of BAD protein by 14-3-3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23430", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3301237", "l": "KAT2 complexes acetylate histone H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16976", "l": "2-hydroxypyridine + AH2 + O2 <=> 2,5-dihydroxypyridine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39864", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol => 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047189", "l": "2,3-diaminopropionate N-oxalyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41175", "l": "[Co(I) dimethylamine-specific corrinoid protein] + dimethylamine + H(+) = [methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine"}, {"i": "EC:2.1.1.249", "l": "\"[Dimethylamine--corrinoid protein] Co-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373733", "l": "Neurofascin binds contactin-1:CASPR complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36254", "l": "(E)-ferulate + ATP + CoA <=> (E)-feruloyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30980", "l": "A + all-trans-lycopene => AH2 + all-trans-3,4-didehydrolycopene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15364", "l": "dolichyl phosphate + UDP-alpha-D-xylose <=> dolichyl D-xylosyl phosphate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18658", "l": "(R)-glycerate + NADP(+) => 3-hydroxypyruvate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624133", "l": "ARL3:GTP binds the UNC119B complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34944", "l": "hydroquinone O-beta-D-glucopyranoside(out) + phosphoenolpyruvate(in) => arbutin 6-phosphate(in) + pyruvate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2509831", "l": "ITPA hydrolyses XTP to XMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202110", "l": "eNOS:Caveolin-1 complex binds to CaM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45670", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41129", "l": "1-dodecanoyl-sn-glycerol + H(+) + phosphocholine => 1-dodecanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25681", "l": "ATP + O-phospho-L-serine + tRNA(Cys) <=> AMP + diphosphate + O-phospho-L-seryl-tRNA(Cys)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12521", "l": "L-dopa => (E)-caffeate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18771", "l": "2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate => 5-methylsulfanyl-2,3-dioxopentyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874080", "l": "SRC phosphorylates PTK2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052835", "l": "inositol-3,4,6-trisphosphate 1-kinase activity"}, {"i": "REACT:R-HSA-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64003", "l": "(4R)-hydroxysphinganine + octadecanoyl-CoA <=> CoA + H(+) + N-octadecanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15672", "l": "5'-dephospho-(DNA) + ATP <=> ADP + H(+) + phospho-5'-(DNA)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222325", "l": "Carboxymycobactin and mycobactin exchange their iron load (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809764", "l": "SBF1 binds MTMR2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692241", "l": "Expression of SRY in testis differentiation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3371422", "l": "ATP hydrolysis by HSP70 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693751", "l": "FAAH2 hydrolyses AEA to AA and ETA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21776", "l": "(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate"}, {"i": "EC:6.2.1.28", "l": "\"3-alpha,7-alpha-dihydroxy-5-beta-cholestanate--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044730", "l": "bone sialoprotein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69053", "l": "RFC binding displaces Pol Alpha (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051911", "l": "Methanosarcina-phenazine hydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29710", "l": "1,6-anhydro-N-acetyl-beta-muramate(in) <=> 1,6-anhydro-N-acetyl-beta-muramate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389849", "l": "28S subunit:MTIF3 binds MTIF2:GTP, mRNA, and formylMet-tRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "81.20444558259193", "identifiers": [{"i": "GO:0008376", "l": "acetylgalactosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686430", "l": "MUS81 binds EME1, EME2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51638", "l": "a quinol + selenate => a quinone + H2O + selenite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37655", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20671", "l": "4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH => 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5631941", "l": "SESN1,2,3 bind AMPK (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40936", "l": "a 1-acylglycerone 3-phosphate + hexadecan-1-ol => 1-O-hexadecylglycerone 3-phosphate + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41490", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32532", "l": "4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate => alpha-D-mannose 1-phosphate + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38559", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + tetracosanoate = (R)-2-hydroxytetracosanoate + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-166387", "l": "The FA anion diffuses away laterally from UCP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18881", "l": "ATP + histamine + L-glutamate = ADP + H(+) + N(alpha)-gamma-L-glutamylhistamine + phosphate"}, {"i": "EC:6.3.2.18", "l": "\"Gamma-glutamylhistamine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47321", "l": "(S)-3-amino-3-phenylpropanoate + 2-oxoglutarate => 3-oxo-3-phenylpropanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31429", "l": "(-)-exo-alpha-bergamotene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67140", "l": "L-cysteinyl-[NO transferase protein] + N(omega)-hydroxy-L-arginine + O2 = H(+) + H2O + L-citrulline + S-nitroso-L-cysteinyl-[NO transferase protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20879", "l": "(R)-2-benzylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.89", "l": "\"Pro-Pro endopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52427", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45217", "l": "[methyl-Co(III) dimethylamine-specific corrinoid protein] + coenzyme M => [Co(I) dimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23568", "l": "(2E)-decenoyl-[ACP] = (3Z)-decenoyl-[ACP]"}, {"i": "EC:5.3.3.14", "l": "\"Trans-2-decenoyl-[acyl-carrier-protein] isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65974", "l": "a peptide antigen(out) + ADP + H(+) + phosphate => a peptide antigen(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60194", "l": "CO2 + formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48718", "l": "13-oxo-(9Z,11E)-octadecadienoate + H2O => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622579", "l": "FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61749", "l": "rubusoside + UDP-alpha-D-glucose => H(+) + stevioside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867047", "l": "PTPN3 dephosphorylates EPS15 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28482", "l": "beta-nicotinamide D-ribonucleotide(in) = beta-nicotinamide D-ribonucleotide(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0097153", "l": "cysteine-type endopeptidase activity involved in apoptotic process"}, {"i": "REACT:R-HSA-6800797", "l": "The PIDDosome activates CASP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008518", "l": "folate:anion antiporter activity"}, {"i": "TCDB:2.A.48"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443418", "l": "GP1b signaling involves c-Src (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666169", "l": "Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56839", "l": "[PQQ precursor protein] + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43433", "l": "2 [Fe(III)cytochrome c] + butan-1-ol => 2 [Fe(II)cytochrome c] + butanal + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45751", "l": "(3Z)-hexenoyl-CoA <=> (2E)-hexenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26019", "l": "beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + H2O = beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate"}, {"i": "EC:3.1.3.79", "l": "\"Mannosylfructose-phosphate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19991", "l": "S-methyl-5-thio-D-ribulose 1-phosphate => S-methyl-5-thio-alpha-D-ribose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392748", "l": "L1 binds to AP-2 Clathrin complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034809", "l": "benzo(a)pyrene-cis-4,5-dihydrodiol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000404", "l": "heteroduplex DNA loop binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852716", "l": "Thrombin, ELANE cleave C5 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062146", "l": "4-chloro-allylglycine synthase activity"}, {"i": "RHEA:59888", "l": "4-chloro-L-lysine + AH2 + O2 = A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-984671", "l": "Chromokinesins form dimers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52124", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15573", "l": "N-acetylserotonin + S-adenosyl-L-methionine = H(+) + melatonin + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.4", "l": "\"Acetylserotonin O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15227", "l": "diphosphate + dTDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + dTTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134800", "l": "STING dimerization (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34053", "l": "6'''-deamino-6'''-hydroxyneomycin C + acetate => 2'''-acetyl-6'''-hydroxyneomycin C + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66119", "l": "2-oxobutanoate + L-glutamine <=> (2S)-2-aminobutanoate + 2-oxoglutaramate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56195", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694723", "l": "Uncoating of SARS-CoV-2 Genome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22715", "l": "adenosylcob(III)inamide phosphate + GTP + H(+) <=> adenosylcob(III)inamide-GDP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61262", "l": "2-oxoglutaramate + H2O2 + NH4(+) => H2O + L-glutamine + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0035259", "l": "glucocorticoid receptor binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047160", "l": "alkylglycerophosphate 2-O-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188985", "l": "trehalose + H2O => 2 D-glucose (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033987", "l": "2-hydroxyisoflavanone dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176318", "l": "Loading of claspin onto DNA during replication origin firing (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-517674", "l": "p-S158,221-HuR binds mRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016163", "l": "nitrogenase activity"}, {"i": "RHEA:21448", "l": "16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] = 16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate"}, {"i": "EC:1.18.6.1", "l": "\"Nitrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12250", "l": "H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine => NADP(+) + UDP-N-acetyl-alpha-D-muramate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662610", "l": "MT1B binds cadmium (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75238", "l": "TRAIL binds TRAIL receptors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5668735", "l": "RAC1:GTP binds NOX3 complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23198", "l": "3 AMP + 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine => 3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50107", "l": "taurine + tetradecanoyl-CoA <=> CoA + H(+) + N-tetradecanoyl-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218814", "l": "PAK2 autophorylates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40700", "l": "1-hexadecanoylglycerone 3-phosphate + octadecan-1-ol => 1-O-octadecylglycerone 3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25284", "l": "(S)-2,3-epoxysqualene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + squalene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52277", "l": "(6S)-5,6,7,8-tetrahydrofolate + 4-hydroxy-3-methoxybenzoate => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4-dihydroxybenzoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58516", "l": "(19S)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] = 15alpha-stemmadenine intermediate I + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44229", "l": "9-decenoate + ATP + CoA => 9-decenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443418", "l": "GP1b signaling involves c-Src (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052806", "l": "sulfite reductase (coenzyme F420) activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004833", "l": "tryptophan 2,3-dioxygenase activity"}, {"i": "REACT:R-HSA-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102030", "l": "dTDP-L-rhamnose synthetase activity"}, {"i": "MetaCyc:DTDPRHAMSYNTHMULTI-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32876", "l": "a 1-acyl-sn-glycerol + H2O => a fatty acid + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64445", "l": "L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-methionine => 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76031", "l": "2 H2O2 => O2 + 2 H2O (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810843", "l": "Envoplakin binds periplakin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688786", "l": "ATXN3 binds RAD23 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52573", "l": "butanoyl-CoA + NAD(+) => (2E)-butenoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784959", "l": "BPHL hydrolyses VACV to ACV (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200646", "l": "Cytosolic folate export across the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35644", "l": "a (2R)-2-hydroxycarboxylate + NAD(+) => a 2-oxocarboxylate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52639", "l": "2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2 <=> a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54918", "l": "9-cis-retinal + H(+) + NADPH => 9-cis-retinol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015544", "l": "phenyl propionate uniporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013143", "l": "RAC1 GEFs activate RAC1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22683", "l": "dCTP + H(+) + H2O <=> dUTP + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18092", "l": "H2O + L-arginyl-[protein] <=> L-citrullyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43025", "l": "an S-substituted L-cysteine => 2-aminoprop-2-enoate + a thiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33919", "l": "H(+) + lanosterol + NADPH = 24,25-dihydrolanosterol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44430", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a 1-acylglycerol => a 1,2-diacyl-sn-glycero-3-phosphocholine + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.1", "l": "\"Aldehyde oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65580", "l": "H2O + TTP = H(+) + phosphate + TDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396007", "l": "IRF3 is phosphorylated by TBK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23504", "l": "adenosylcob(III)inamide + H2O = (R)-1-aminopropan-2-ol + adenosylcob(III)yrate"}, {"i": "EC:3.5.1.90", "l": "\"Adenosylcobinamide hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683831", "l": "CCDC59 binds TTF1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020274", "l": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35266", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19273", "l": "H2O + N-acetyl-D-mannosamine + phosphoenolpyruvate = N-acetylneuraminate + phosphate"}, {"i": "EC:2.5.1.56", "l": "\"N-acetylneuraminate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.-", "l": "\"Phosphorus-oxygen lyases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15177", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine"}, {"i": "EC:3.1.1.5", "l": "\"Lysophospholipase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050301", "l": "streptomycin-6-phosphatase activity"}, {"i": "MetaCyc:STREPTOMYCIN-6-PHOSPHATASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912727", "l": "CBL binds VAV (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16732", "l": "(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) <=> catechol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396379", "l": "NOTCH1 Coactivator Complex binds HES5 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18480", "l": "2,3-dihydroxybenzoate + O2 <=> 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53459", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z-octadecenoate)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29165", "l": "2 H2O(out) + 3 menaquinone-8(in) + NH4(+)(out) => 2 H(+)(out) + 3 menaquinol-8(in) + nitrite(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030020", "l": "extracellular matrix structural constituent conferring tensile strength"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664850", "l": "ATM binds PEX5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38629", "l": "1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11634", "l": "A + H(+) + hydrogenselenide + L-alanine => AH2 + L-selenocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3132753", "l": "Pancreatic proteases degrade TCN1:Cbl (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49934", "l": "(2E,5Z)-octadienoyl-CoA => (3E,5Z)-octadienoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42539", "l": "uridine(65) in tRNA <=> pseudouridine(65) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41411", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983707", "l": "SYK autophosphorylates at the activated BCR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610720", "l": "PKA phosphorylates GLI3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43688", "l": "N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + pyruvate = L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64627", "l": "(2E)-geraniol + acetyl-CoA <=> (2E)-geranyl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24259", "l": "ATP + kanamycin A <=> ADP + H(+) + kanamycin 3'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24463", "l": "H(+) + malonyl-[ACP] <=> acetyl-[ACP] + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2129353", "l": "Tropoelastin associates with microfibrils (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36574", "l": "sphinganine + tetradecanoyl-CoA <=> CoA + H(+) + N-(tetradecanoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008970", "l": "phospholipase A1 activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.23", "l": "\"7-chloro-L-tryptophan oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994169", "l": "F-actin capping protein binds to the barbed end of elongating F-actin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66248", "l": "CoA + IC-asc-C9-AMP = AMP + H(+) + IC-asc-C9-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21059", "l": "lactoyl-CoA <=> acryloyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37568", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine => 1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953037", "l": "E2F8 forms homodimers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701562", "l": "CD274 gene expression downstream of ALK signaling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008715", "l": "CDP-diacylglycerol diphosphatase activity"}, {"i": "RHEA:15221", "l": "a CDP-1,2-diacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+)"}, {"i": "EC:3.6.1.26", "l": "\"CDP-diacylglycerol diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661517", "l": "LUBAC comlex binds OTULIN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-169895", "l": "Crk's SH3 domain engages C3G (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700648", "l": "Active ALK binds SRC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003856", "l": "3-dehydroquinate synthase activity"}, {"i": "RHEA:21968", "l": "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate"}, {"i": "EC:4.2.3.4", "l": "\"3-dehydroquinate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28966", "l": "H(+)(out) + L-proline(out) <=> H(+)(in) + L-proline(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047572", "l": "3-phosphoglycerate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.-", "l": "\"With other acceptors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3095901", "l": "ABCC1 transports cytosolic Cbl to extracellular region (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650710", "l": "Translation of PPP1R15A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938158", "l": "PRKCQ gene expression is stimulated by RUNX1:CBFB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32335", "l": "(1S,2S,4R)-endo-fenchol + NADP(+) = (1S,4R)-fenchone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416698", "l": "SEMA5A binds to PLXNB3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44366", "l": "2-epi-5-epi-valiolone 7-phosphate + ADP + H(+) => 2-epi-5-epi-valiolone + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203613", "l": "depalmitoylation of eNOS (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2130194", "l": "ABL phosphorylates WAVEs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626981", "l": "TNF-alpha:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193761", "l": "25(R) TetraHCA-CoA is translocated from the cytosol to the peroxisome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3321883", "l": "MSL acetylates histone H4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800797", "l": "The PIDDosome activates CASP2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21302", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate => H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684008", "l": "NBN binds KPNA2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.21", "l": "\"Beta-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814374", "l": "Kazrin binds periplakin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610722", "l": "CK1 phosphorylates p-GLI3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39046", "l": "22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5679239", "l": "ULK complex translocates to the ER (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2106615", "l": "Removal of siRNA passenger strand (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8856808", "l": "Recruitment of AP-2 complex and clathrin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54340", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200406", "l": "CPT1A,B transfers PALM to CAR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49577", "l": "AH2 + GTP + S-adenosyl-L-methionine => (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58689", "l": "NADH + O2 + rifamycin SV => H2O + NAD(+) + rifamycin SV para-naphthoquinone carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64059", "l": "(1S,2R)-ephedrine + NAD(+) <=> (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42920", "l": "S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.193", "l": "\"16S rRNA (uracil(1498)-N(3))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53557", "l": "(9R,10S)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(9R,10S)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2660815", "l": "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15859", "l": "17alpha-hydroxyprogesterone + H(+) + NADPH => 17alpha,20alpha-dihydroxypregn-4-en-3-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21420", "l": "NADP(+) + prostaglandin I2 = 15-dehydro-prostaglandin I2 + H(+) + NADPH"}, {"i": "EC:1.1.1.231", "l": "\"15-hydroxyprostaglandin-I dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112436", "l": "Formation of Elongin complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41044", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + octanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-octanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39939", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54695", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (13E)-labda-7,13-dien-15-yl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607838", "l": "Defective UNC93B1 does not bind TLR3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31224", "l": "cis-beta-D-glucosyl-2-hydroxycinnamate + H2O => beta-D-glucose + cis-2-coumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001855", "l": "complement component C4b binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034597", "l": "phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603905", "l": "Expression of NLRP3 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451366", "l": "Activation of p38MAPK by DSCAM (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36095", "l": "S-adenosyl-L-methionine + salicylate = methyl salicylate + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.274", "l": "\"Salicylate carboxymethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30041", "l": "benzene-1,2,4-triol + CO2 + H2O + NADP(+) => 3,4-dihydroxybenzoate + 2 H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2395320", "l": "Latent TGF-beta-1 binds integrins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49139", "l": "H(+) + L-methionyl-[protein] + NADPH + O2 <=> H2O + L-methionyl-S-oxide-[protein] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36613", "l": "(5R)-carbapenem-3-carboxylate + CO2 + H2O + succinate => (3S,5S)-carbapenam-3-caboxylate + 2-oxoglutarate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58795", "l": "ATP + Fe(III)-petrobactin(out) + H2O <=> ADP + Fe(III)-petrobactin(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8957241", "l": "TP73 tetramer translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53582", "l": "20-hydroxy-14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448660", "l": "IL31:IL31RA:JAK1 binds OSMR:JAK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102513", "l": "delphinidin 3-O-glucoside 5-O-glucosyltransferase (vanilloyl-glucose dependent) activity"}, {"i": "MetaCyc:RXN-14442"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13343", "l": "5'-deoxyadenosine + an 8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine => a menaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30039", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADPH + O2 = benzene-1,2,4-triol + CO2 + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12746", "l": "a 1,4-lactone + H2O => a 4-hydroxyacid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944246", "l": "Association of procollagen type XXI (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21591", "l": "N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate <=> H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102611", "l": "(+)-secoisolariciresinol monoglucoside glucosyltransferase activity"}, {"i": "MetaCyc:RXN-15443"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32710", "l": "(2E)-geranyl diphosphate <=> (2R,4S)-bornyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62974", "l": "3 CO2 + 4 CoA + orsellinate => acetyl-CoA + 2 H(+) + 3 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51913", "l": "(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26205", "l": "4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+)"}, {"i": "EC:1.14.13.n7", "l": "\"4-nitrophenol 2-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27434", "l": "2 glutathione amide + NAD(+) => glutathione amide disulfide + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52728", "l": "3'-phosphoadenylyl sulfate + a 12-hydroxyjasmonate = a 12-sulfojasmonate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559414", "l": "Activated TLR2/4:TIRAP interacts with BTK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168886", "l": "Hemopexin binds Hemes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39845", "l": "a triacyl-sn-glycerol + CoA => 1,3-diacyl-sn-glycerol + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052845", "l": "inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity"}, {"i": "MetaCyc:RXN-10964"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41529", "l": "(2E)-octenoyl-[ACP] + H(+) + NADH => NAD(+) + octanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873923", "l": "STARD10 binds LPCAT1 and PC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018799", "l": "4-hydroxybenzoate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426209", "l": "DAG activation of TRPC channels (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222686", "l": "Nitric oxide diffuses into the phagosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36843", "l": "(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56777", "l": "(+)-pinoresinol + O2 + reduced [NADPH--hemoprotein reductase] => (+)-piperitol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21442", "l": "a long-chain alkane + formate + H2O + 2 NADP(+) => a long-chain fatty aldehyde + H(+) + 2 NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40783", "l": "docosanoyl-CoA + H2O = CoA + docosanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24952", "l": "1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O = ADP + H(+) + N-acetyl-D-muramate 6-phosphate"}, {"i": "EC:2.7.1.170", "l": "\"Anhydro-N-acetylmuramic acid kinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047124", "l": "L-erythro-3,5-diaminohexanoate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15232", "l": "alpha-D-mannose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29678", "l": "glycerol(in) <=> glycerol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0042030", "l": "ATPase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874849", "l": "CREBRF binds CREB3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700156", "l": "Active ALK dimer binds IRS1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21871", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O <=> 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54589", "l": "S-adenosyl-L-methionine + uridine in 25S rRNA => H(+) + N(3)-methyluridine in 25S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703437", "l": "FLT3 fusion dimers autophosphorylate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26454", "l": "NADP(+) + propanoyl-CoA = acryloyl-CoA + H(+) + NADPH"}, {"i": "EC:1.3.1.84", "l": "\"Acrylyl-CoA reductase (NADPH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41110", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O <=> 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35216", "l": "H2O + XDP => H(+) + phosphate + XMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18137", "l": "3beta-hydroxy-5alpha-pregnane-20-one + NADP(+) = 5alpha-pregnane-3,20-dione + H(+) + NADPH"}, {"i": "EC:1.1.1.278", "l": "\"3-beta-hydroxy-5-alpha-steroid dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13519", "l": "ADP + dTDP => ATP + dTMP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052577", "l": "germacrene-D synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47826", "l": "3-oxoeicosanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + malonyl-[ACP] + octadecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40202", "l": "hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19486", "l": "sphing-4-enine + UDP-alpha-D-galactose => beta-D-galactosyl-(1<->1)-sphing-4-enine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352268", "l": "Cleavage of Satb1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54230", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine => 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.33", "l": "\"Delta(12) acyl-lipid conjugase (11E,13E-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38597", "l": "(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+) => 1,3-di-(9Z-octadecenoyl)-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17653", "l": "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate"}, {"i": "EC:2.5.1.29", "l": "\"Geranylgeranyl diphosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33909", "l": "4-aminobutanoate + formaldehyde + H2O2 => 4-(methylamino)butanoate + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620837", "l": "CCNG2 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001054", "l": "RNA polymerase I activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937869", "l": "RUNX2:CBFB:p-Y-YAP1 binds the BGLAP gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022911", "l": "CSPG is secreted (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41405", "l": "(R)-2-methylpyrrolidine + NADP(+) => 2-methyl-1-pyrroline + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20139", "l": "baccatin III + CoA => 10-deacetylbaccatin III + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033432", "l": "CGG codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74059", "l": "PDE6 hydrolyses cGMP to GMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23689", "l": "adenine + H(+) + H2O => hypoxanthine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42891", "l": "(R)-3-phosphomevalonate + ATP <=> (R)-3,5-bisphosphomevalonate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50702", "l": "calcitriol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => calcidiol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54738", "l": "2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine => N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53943", "l": "O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 <=> 18-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66417", "l": "ATP + glutathione(in) + glycoursodeoxycholate(in) + H2O => ADP + glutathione(out) + glycoursodeoxycholate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37933", "l": "(10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate => (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12727", "l": "H(+) + keto-D-sorbose + NADH => D-iditol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48873", "l": "a gentamycin + GTP => a gentamycin 2''-phosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10500", "l": "butanoyl-CoA + glyoxylate + H2O = 3-ethylmalate + CoA + H(+)"}, {"i": "EC:2.3.3.7", "l": "\"3-ethylmalate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41916", "l": "H(+) + hexadecanoyl-[ACP] + malonyl-[ACP] = 3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57748", "l": "2 (S)-methylmalonyl-CoA + 10 H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 3 malonyl-CoA + 5 NADPH = C32-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114553", "l": "Activation of conventional Protein Kinase C (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49152", "l": "dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine = dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58448", "l": "N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.104", "l": "\"Steryl-beta-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37605", "l": "1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50761", "l": "a quinone + H2O + sulfite => a quinol + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875523", "l": "MET binds TNS3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52386", "l": "H(+) + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate => L-glutamate + O-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47925", "l": "2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate => (S)-3-sulfolactaldehyde + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50475", "l": "anthraniloyl-CoA + H(+) + malonyl-CoA <=> (2-aminobenzoyl)acetyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55942", "l": "all-trans-3,4-didehydroretinal + H(+) + NADH => all-trans-3,4-didehydroretinol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28396", "l": "L-alanyl-D-glutamate => L-alanyl-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66916", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 9-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11091", "l": "H2O + trimetaphosphate <=> 2 H(+) + triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32457", "l": "2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + solavetivone => (-)-vetispiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27300", "l": "2 H(+) + NADH + phthalate => 2-formylbenzoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855188", "l": "IP6 transports from the cytosol to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47397", "l": "H2O + octadecanoate ester => an aliphatic alcohol + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22965", "l": "H(+) + L-ornithine => CO2 + putrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24756", "l": "H(+) + NADPH + O2 + pheophorbide a = NADP(+) + red chlorophyll catabolite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0052666", "l": "tRNA (cytosine-2'-O-)-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809010", "l": "COPI vesicle uncoating (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853745", "l": "RET binds GFRA1,GFRA3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29904", "l": "ATP + D-ribose(out) + H2O => ADP + D-ribose(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52917", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate => 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21390", "l": "L-lysine => H2O + L-2-aminohexano-6-lactam"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26364", "l": "L-tyrosine + NADPH + S-adenosyl-L-methionine <=> 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047178", "l": "glycerophospholipid acyltransferase (CoA-dependent) activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047288", "l": "monosialoganglioside sialyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26548", "l": "beta-alanine + NH4(+) => beta-alaninamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000210", "l": "NAD+ diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030559", "l": "rRNA pseudouridylation guide activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62070", "l": "2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADPH => 2-deoxy-D-glucose 6-phosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24673", "l": "H2O + hypoxanthine + NAD(+) <=> H(+) + NADH + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31056", "l": "estrone 3-sulfate + H2O => estrone + H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52677", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O => [amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.26", "l": "\"Intermediate cleaving peptidase 55\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428231", "l": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-430308", "l": "PARVB interacts with Alpha-actinin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004631", "l": "phosphomevalonate kinase activity"}, {"i": "RHEA:16341", "l": "(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP"}, {"i": "EC:2.7.4.2", "l": "\"Phosphomevalonate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62517", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43542", "l": "ADP + H(+) + O-phospho-L-seryl-[isocitrate dehydrogenase] => ATP + L-seryl-[isocitrate dehydrogenase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34435", "l": "4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine = 4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.261", "l": "\"4-dimethylallyltryptophan N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44460", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol = a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420724", "l": "CASR binds Ca2+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31609", "l": "all-trans-lycopene + H2O => rhodopin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60273", "l": "N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390329", "l": "Dephosphorylation of AKT by PP2A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050044", "l": "galactose-6-phosphate isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9690494", "l": "RHOB translocates to the endosome membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53284", "l": "NAD(+) + scyllo-inosose = 3-dehydro-scyllo-inosose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15660", "l": "1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) <=> 3-methylcatechol + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052729", "l": "dimethylglycine N-methyltransferase activity"}, {"i": "KEGG.REACTION:R07244"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167478", "l": "Abortive termination of HIV-1 early transcription elongation by DSIF:NELF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56653", "l": "12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+) => 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33569", "l": "acetaldehyde + AH2 => A + ethanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64553", "l": "(3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + O2 + reduced [NADPH--hemoprotein reductase] => 3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103085", "l": "2-(5'-methylthio)pentylmalate synthase activity"}, {"i": "MetaCyc:RXNQT-4169"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41159", "l": "1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944632", "l": "miR-106 microRNAs bind PTEN mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684273", "l": "3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17560", "l": "anthranilate + malonyl-CoA <=> CoA + N-malonylanthranilate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.49"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23674", "l": "3-dehydroquinate + a quinol => a quinone + L-quinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42849", "l": "8-demethyltetracenomycin C + dTDP-beta-L-rhamnose => 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610735", "l": "NUMB binds ITCH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67094", "l": "ADP + docosanoate(out) + H(+) + phosphate => ATP + docosanoate(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018744", "l": "limonene-1,2-epoxide hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63873", "l": "2-oxoglutarate + L-isoleucine + O2 => 3(1)-hydroxy-L-isoleucine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375140", "l": "CDO binds promyogenic cadherins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16990", "l": "1D-myo-inositol hexakisphosphate + H2O => 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202510", "l": "Activation of TAK1-TAB2 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64770", "l": "2-aminoprop-2-enoate + 3-sulfanyl-1-hexanol => S-3-(hexan-1-ol)-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46713", "l": "pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706350", "l": "FLT3 phosphorylates CBL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69891", "l": "Phosphorylation and activation of CHEK2 by ATM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693356", "l": "CEMIP hydrolyses HA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17349", "l": "(2E)-geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole = 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate"}, {"i": "EC:2.5.1.146", "l": "\"3-geranyl-3-((Z)-2-isocyanoethenyl)indole synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004453", "l": "juvenile-hormone esterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65080", "l": "asperaculane D + O2 + reduced [NADPH--hemoprotein reductase] = asperaculane E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050322", "l": "taurine-2-oxoglutarate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15532", "l": "bis(2-ethylhexyl)phthalate + H2O <=> 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036141", "l": "L-phenylalanine-oxaloacetate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65815", "l": "2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + AH2 + O2 <=> A + H2O + N(6)-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-2-(methylsulfanyl)adenosine(37) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862733", "l": "CCR2, CCR3 bind CCL13 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11860", "l": "ATP + L-histidyl-[protein] = ADP + H(+) + N(tele)-phospho-L-histidyl-[protein]"}, {"i": "EC:2.7.13.2", "l": "\"Protein-histidine tele-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30548", "l": "(3S)-hydroxyhexanoyl-CoA => (2E)-hexenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805811", "l": "Release of SEPT4 from mitochondria (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46029", "l": "H2O2 + tetradecanoate => (2R)-hydroxytetradecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21847", "l": "L-glutamine + phenylacetyl-CoA <=> CoA + H(+) + N(2)-phenylacetyl-L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52628", "l": "an N-fatty-acyl-L-alpha-amino acid + H2O = a fatty acid + an L-alpha-amino acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-422454", "l": "Polysialylation of NCAM1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034200", "l": "D,D-heptose 1,7-bisphosphate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045523", "l": "interleukin-27 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53134", "l": "a 3-oxo-Delta(1,4)-steroid + AH2 => A + a 3-oxo-Delta(4)-steroid"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050181", "l": "phorbol-diester hydrolase activity"}, {"i": "RHEA:21316", "l": "H2O + phorbol 12,13-dibutanoate = butanoate + H(+) + phorbol 13-butanoate"}, {"i": "EC:3.1.1.51", "l": "\"Phorbol-diester hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10568", "l": "luteolin + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-beta-D-glucuronide + UDP"}, {"i": "EC:2.4.1.189", "l": "\"Luteolin 7-O-glucuronosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2467811", "l": "Separation of sister chromatids (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59666", "l": "D-cellopentaono-1,5-lactone + H2O2 => D-cellopentaose + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102349", "l": "trans-lignocero-2-enoyl-CoA reductase activity"}, {"i": "MetaCyc:RXN-13308"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62609", "l": "glutathione + H(+) + hydrogen sulfide + ubiquinone-10 => S-sulfanylglutathione + ubiquinol-10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58215", "l": "ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] <=> dihydroserpentine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975122", "l": "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60225", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011950", "l": "Estrogen-responsive GREB1 gene transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34270", "l": "acetyl-CoA + fumigaclavine B <=> CoA + fumigaclavine A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158795", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39157", "l": "(2E)-octadecenoyl-CoA + H2O => (3R)-hydroxyoctadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56056", "l": "genistein + UDP-alpha-D-glucose = genistein 7-O-beta-D-glucoside + H(+) + UDP"}, {"i": "EC:2.4.1.170", "l": "\"Isoflavone 7-O-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25121", "l": "(S)-2-amino-6-oxohexanoate = H(+) + H2O + L-1-piperideine-6-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876472", "l": "NPC2 binds CHOL (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24740", "l": "6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH => (6R)-5,6,7,8-tetrahydrobiopterin + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47560", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) = CMP + ganglioside GM1b (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60442", "l": "acetate + H(+) + methanol => H2O + methyl acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28693", "l": "a ubiquinol + orotate => (S)-dihydroorotate + a ubiquinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201630", "l": "Caspase-mediated cleavage of Acinus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381091", "l": "IRE1 dimer autophosphorylates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391942", "l": "IP receptor can bind prostacyclin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801166", "l": "TP53 binds the STEAP3 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956050", "l": "NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35592", "l": "H2 + n sulfur => H(+) + hydrogen sulfide + (n-1) sulfur"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43655", "l": "decanoyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxododecanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14870", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O => acetate + an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9646468", "l": "mTORC1 binds RHEB:GTP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222020", "l": "NUAK1 phosphorylates TP53 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38566", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + H2O <=> 1-O-hexadecyl-sn-glycerol + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60801", "l": "2-oxoglutarate + gibberellin A53 + O2 => CO2 + gibberellin A44 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12921", "l": "glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO2 + CoA"}, {"i": "EC:2.3.1.37", "l": "\"5-aminolevulinate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954199", "l": "CXCL12 gene expression is stimulated by ERBB4s80:ESR1:estrogen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41421", "l": "2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2 => CO2 + grixazone B + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57495", "l": "H2O + oxaloacetate + propanoyl-CoA <=> 2-methylcitrate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39509", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+) => 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730851", "l": "Phosphorylation of SLP-76 by p-SYK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451900", "l": "IL2RB binds JAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66189", "l": "3',5'-cyclic GMP(in) + ATP + H2O => 3',5'-cyclic GMP(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63320", "l": "a glycerophospholipid(in) + ATP + H2O = a glycerophospholipid(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683670", "l": "Protein E forms a homopentamer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683774", "l": "p-T68-CHEK2 dimerizes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.2.-", "l": "\"With a cytochrome as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080081", "l": "4-methylumbelliferyl-beta-D-glucopyranoside beta-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085083", "l": "Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5252133", "l": "ATP6AP1 binds V-ATPase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2980720", "l": "NEK9 binds NEK6/NEK7 in the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44685", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080075", "l": "spermidine:feruloyl CoA N-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20127", "l": "NADPH + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210444", "l": "L-Glutamate loading of synaptic vesicle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682598", "l": "ATM phosphorylates HERC2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40850", "l": "eicosanoyl-CoA + FAD + H(+) <=> (2E)-eicosenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021948", "l": "GPRIN1 gene expression is stimulated by MECP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0015112", "l": "nitrate transmembrane transporter activity"}, {"i": "RHEA:34923", "l": "nitrate(in) = nitrate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2172433", "l": "Collagen type XIX degradation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15780", "l": "1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O <=> 1-guanidino-1-deoxy-scyllo-inositol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31315", "l": "(2R)-3-phosphoglycerate + GDP-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61066", "l": "beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + H(+) + UDP => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66350", "l": "(2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + AH2 => 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66738", "l": "ADP + beta-citrylglutamate(out) + H(+) + phosphate => ATP + beta-citrylglutamate(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047175", "l": "galactosylacylglycerol O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418856", "l": "Activation of Rac1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2203480", "l": "COLEC11 binds ligands (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55301", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57892", "l": "a quinone + 5 H(+)(in) + NADPH = a quinol + 4 H(+)(out) + NADP(+)"}, {"i": "EC:7.1.1.2", "l": "\"NADH:ubiquinone reductase (H(+)-translocating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44770", "l": "2-methoxy-6-(all-trans-hexaprenyl)phenol + CO2 => 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59613", "l": "beta-alanyl-L-ornithine + H2O => beta-alanine + L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54467", "l": "1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018769", "l": "2-hydroxy-6-oxoocta-2,4-dienoate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.77"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112690", "l": "PTPN11 binds CBL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33070", "l": "(4R)-hydroxysphinganine 1-phosphate + H2O <=> (4R)-hydroxysphinganine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203700", "l": "eNOS translocation from Golgi to Caveolae (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033423", "l": "CCA codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35596", "l": "benzene-1,2,4-triol + O2 => 2 H(+) + maleylacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61531", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base <=> a diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66760", "l": "ATP + H2O + kainate(in) = ADP + H(+) + kainate(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159001", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856808", "l": "Recruitment of AP-2 complex and clathrin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49909", "l": "(R)-carnitine(out) + O-acetyl-(R)-carnitine(in) => (R)-carnitine(in) + O-acetyl-(R)-carnitine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23787", "l": "a quinone + L-proline <=> (S)-1-pyrroline-5-carboxylate + a quinol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855375", "l": "PTPN22 dissociates from CSK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.19", "l": "\"Glutamyl endopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9669854", "l": "KIT binds type II TKIs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62687", "l": "norrubrofusarin + S-adenosyl-L-methionine <=> H(+) + rubrofusarin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39106", "l": "(24R)-ethylcholest-5-en-3beta-ol(in) + ATP + H2O <=> (24R)-ethylcholest-5-en-3beta-ol(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2530445", "l": "CD59 inhibits MAC formation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28392", "l": "N(6)-(D-fructosyl)-L-lysine => N(6)-(D-psicosyl)-L-lysine"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0034593", "l": "phosphatidylinositol bisphosphate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67147", "l": "2-oxoglutarate + jasmonate + O2 <=> (1R,2R)-12-hydroxyjasmonate + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33579", "l": "NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate = H(+) + NADH + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate"}, {"i": "EC:1.1.1.335", "l": "\"UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112434", "l": "Formation of DSIF complex  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11334", "l": "diphosphate + RNA(n)-3'-adenine ribonucleotide => ATP + RNA(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72672", "l": "The 60S subunit joins the translation initiation complex  (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40320", "l": "O2 + tetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39337", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+) => 3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18569", "l": "an aromatic aldehyde + H2O + O2 = an aromatic carboxylate + H(+) + H2O2"}, {"i": "EC:1.2.3.9", "l": "\"Aryl-aldehyde oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61479", "l": "a sphingoid base + octadecanoyl-CoA <=> an N-octadecanoyl-sphingoid base + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44531", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61977", "l": "glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine => 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48687", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O <=> [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102068", "l": "alpha-humulene 10-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39693", "l": "(11Z)-octadecenoyl-CoA + NADP(+) => (2E,11Z)-octadecadienoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23413", "l": "H2O + N-acetylputrescine => acetate + putrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800001", "l": "TP53 family members stimulate FAS gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61741", "l": "steviolmonoside + UDP-alpha-D-glucose => H(+) + steviolbioside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937682", "l": "RUNX1 binds SRC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70494", "l": "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18842", "l": "(R)-glycerate + NADP(+) => 2-hydroxy-3-oxopropanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679775", "l": "COMT binds COMT Inhibitors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26225", "l": "abieta-7,13-dien-18-al + H2O + NAD(+) = abieta-7,13-dien-18-oate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.74", "l": "\"Abieta-7,13-dien-18-al dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45492", "l": "[phycoerythrocyanin beta-subunit]-Cys(84)-phycocyanobilin = (2R,3E)-phycocyanobilin + apo-[phycoerythrocyanin beta-subunit]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928646", "l": "EPHAs bind EFNAs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34702", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-alpha-isocomene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951676", "l": "RUNX3 binds TEADs and YAP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989748", "l": "Expression of GRHL1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46266", "l": "2 [Fe(III)-cytochrome b5] + a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 H2O => 2 [Fe(II)-cytochrome b5] + an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-114553", "l": "Activation of conventional Protein Kinase C (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180739", "l": "Association of RanBP1 with Ran-GTP:CRM1:Rev:mRNA complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193665", "l": "MYD88 dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004660", "l": "protein farnesyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2534096", "l": "METAP1/2 demethylates GNAT1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4570528", "l": "SUMOylation of XPC with SUMO1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2529020", "l": "CK2 phosphorylates condensin I subunits (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30782", "l": "D-gluconate + FAD + H(+) <=> 2-dehydro-D-gluconate + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16700", "l": "A + H2O + quinaldate <=> AH2 + kynurenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17146", "l": "2'-hydroxy-2,3-dihydrodaidzein + NADP(+) => 2'-hydroxydaidzein + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419428", "l": "S1PR2-5 bind S1P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788622", "l": "p-Y-STATs dimerize (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6801687", "l": "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031172", "l": "ornithine N5-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42840", "l": "acetyl-CoA + 6 H(+) + 5 malonyl-CoA + 2 NADPH = 2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 3 H2O + 2 NADP(+)"}, {"i": "EC:2.3.1.237", "l": "\"Neocarzinostatin naphthoate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22325", "l": "H2O + leukotriene A4 => leukotriene B4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2219524", "l": "PDPK1 binds PIP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192916", "l": "Initiation of vRNA Synthesis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19062", "l": "H2O + NADP(+) + nitrite => H(+) + NADPH + nitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425861", "l": "Activation of Protein Kinase C novel isoforms (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0032440", "l": "2-alkenal reductase [NAD(P)+] activity"}, {"i": "EC:1.3.1.74", "l": "\"2-alkenal reductase (NAD(P)(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37099", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O = a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23069", "l": "6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA => 6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614591", "l": "Excess cysteine yields lanthionine and H2S (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0031545", "l": "peptidyl-proline 4-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3858489", "l": "ppDVL binds DAAM1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49582", "l": "cyclic pyranopterin phosphate + diphosphate => (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868567", "l": "CDK5:p25 phosphorylates PRDX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72691", "l": "Formation of the 43S pre-initiation complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062152", "l": "mRNA (cytidine-5-)-methyltransferase activity"}, {"i": "RHEA:61464", "l": "a cytidine in mRNA + S-adenosyl-L-methionine = a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25382", "l": "2-hydroxy-3-methylhexadecanoyl-CoA <=> 2-methylpentadecanal + formyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.98", "l": "\"Hepacivirin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11697", "l": "3'-demethylstaurosporine + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + staurosporine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67083", "l": "a very long-chain fatty acid(in) + ATP + H2O <=> a very long-chain fatty acid(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18755", "l": "[protein]-disulfide + H(+) + NADPH => [protein]-dithiol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34976", "l": "(R)-pantothenate(in) => (R)-pantothenate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45525", "l": "[C-phycocyanin alpha-subunit]-Cys(84)-phycocyanobilin => (2R,3E)-phycocyanobilin + apo-[C-phycocyanin alpha-subunit]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607736", "l": "MALT1 oligomerizes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39449", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+) => (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45360", "l": "H2O + N-(11Z-eicosenoyl)-sphinganine = (11Z)-eicosenoate + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53001", "l": "17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D-glucuronate => 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66136", "l": "acetyl-CoA + tyramine = CoA + H(+) + N-acetyltyramine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445064", "l": "Activation of Rac1 by VAV2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684336", "l": "nsp1-4 cleaves itself (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40470", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O <=> (9Z)-octadecenoate + 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52963", "l": "hyocholate + UDP-alpha-D-glucuronate <=> hyocholoyl-24-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55103", "l": "3-oxopentanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxypentanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30483", "l": "N-hydroxy-L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.19"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.175"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564169", "l": "Collagen type VIII degradation by MMP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41299", "l": "H2O + N-(9Z-octadecenoyl)-sphing-4-enine = (9Z)-octadecenoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13846", "l": "dihydroxyfumarate + H(+) => 2-hydroxy-3-oxopropanoate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201457", "l": "BMP2 binds to the receptor complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13124", "l": "ATP + shikimate <=> 3-phosphoshikimate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49780", "l": "docosanoyl-CoA + glycine = CoA + H(+) + N-docosanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873919", "l": "Phosphorylation of JAK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031839", "l": "type 1 neuromedin U receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018798", "l": "RHOV binds GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14828", "l": "(1R,5S)-carveol + NAD(+) <=> (S)-carvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.10.1", "l": "\"Receptor protein-tyrosine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2025890", "l": "Calcineurin binds NFATC1,2,3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102461", "l": "kaempferol 3-sophoroside 7-O-rhamnosyltransferase activity"}, {"i": "MetaCyc:RXN-14009"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47244", "l": "(2R)-3-phosphoglycerate + an NDP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26384", "l": "4-hydroxybutanoate + NADP(+) <=> H(+) + NADPH + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66859", "l": "(2E)-geranyl diphosphate + 3 isopentenyl diphosphate <=> (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51794", "l": "2,3-dihydroxybenzoate + H2O + NAD(+) => H(+) + NADH + O2 + salicylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870710", "l": "APP gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034604", "l": "pyruvate dehydrogenase (NAD+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033787", "l": "cyanocobalamin reductase (cyanide-eliminating) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39668", "l": "a secondary alcohol + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) => a ketone + reduced coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980123", "l": "DTX recruits beta-arrestin (ARRB) to NOTCH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5669012", "l": "EDA binds EDAR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432455", "l": "Nuclear PER is degraded by the 26S proteasome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389026", "l": "Galanin receptors can bind galanin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56404", "l": "[(3R)-hydroxybutanoate](n) + H2O = (3R)-hydroxybutanoate pentamer + [(3R)-hydroxybutanoate](n-5) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56934", "l": "17beta-hydroxy-androst-5-en-3-one + H(+) + NADH => androst-5-en-3beta,17beta-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018486", "l": "2-butanone oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45989", "l": "3,17-dihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMNH2 + O2 => 3,4,17-trihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMN + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046538", "l": "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10156", "l": "dihydrochelirubine + O2 + reduced [NADPH--hemoprotein reductase] = 12-hydroxydihydrochelirubine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.101", "l": "\"Dihydrochelirubine 12-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13848", "l": "dihydroxyfumarate + H(+) <=> 2-hydroxy-3-oxopropanoate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021412", "l": "PBX1 gene expression is stimulated by NOTCH3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0031841", "l": "neuropeptide Y receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696267", "l": "RND3 binds GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31784", "l": "H2O + tuberculosinyl diphosphate => diphosphate + tuberculosinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13075", "l": "guanosine 3',5'-bis(diphosphate) + H(+) + phosphate => guanosine 3'-diphosphate 5'-triphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9647746", "l": "EML4 trimerizes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210444", "l": "L-Glutamate loading of synaptic vesicle (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029454", "l": "Autophosphorylation of PAK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18466", "l": "L-dopa + O2 => 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "74.378130331796413", "identifiers": [{"i": "GO:0004527", "l": "exonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877153", "l": "STARD7 binds PC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-976768", "l": "Factor H binds to C3b (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399952", "l": "Phosphorylation of LIMK-1 by PAK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940134", "l": "FOLR2 binds FOLA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1006169", "l": "Factor H binds host cell surface markers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928615", "l": "EFNBs bind SFKs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61098", "l": "(S)-eriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3828025", "l": "DCN (decorin) degradation by MMP14 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14502", "l": "H2O + L-homocysteine => 2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55017", "l": "H(+) + menthone + NADPH + O2 => 7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61638", "l": "AMP + diphosphate + isophthalyl-CoA => ATP + CoA + isophthalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21240", "l": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10955", "l": "(E)-sinapoyl-CoA + hydroxymalonate <=> (E)-sinapoyltartronate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52518", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + H(+) + ubiquinol-10 => trans-4-hydroxy-L-proline + ubiquinone-10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12616", "l": "2 glutathione + L-cystine <=> glutathione disulfide + 2 L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67115", "l": "L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36725", "l": "2-phenylacetaldehyde + AH2 + NH4(+) => 2-phenylethylamine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17001", "l": "amidinoproclavaminate + H2O = proclavaminate + urea"}, {"i": "EC:3.5.3.22", "l": "\"Proclavaminate amidinohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30886", "l": "D-glucurono-3,6-lactone + 2 H2O + NAD(+) <=> D-glucarate + 3 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102990", "l": "5-n-alk(en)ylresorcinol O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018622", "l": "4-chlorophenylacetate 3,4-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52071", "l": "9-(9Z-hexadecenoyloxy)-octadecanoate + H2O <=> (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454208", "l": "Phosphorylation of beta and gamma subunits by LYN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1461971", "l": "Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047058", "l": "vitamin-K-epoxide reductase (warfarin-insensitive) activity"}, {"i": "RHEA:21560", "l": "3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol = 1,4-dithiothreitol + 2,3-epoxyphylloquinone"}, {"i": "EC:1.17.4.5", "l": "\"Vitamin-K-epoxide reductase (warfarin-insensitive)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29663", "l": "H(+)(in) + xanthine(in) = H(+)(out) + xanthine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11261", "l": "H(+) + NADPH + O2 => H2O2 + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37798", "l": "2 H(+) + 2 NADPH + O2 <=> 2 H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44118", "l": "CoA + eicosanyl hexadecanoate => eicosan-1-ol + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800035", "l": "IGFBP3 binds TMEM219 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59689", "l": "D-maltoheptaose + O2 => D-maltoheptaono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712087", "l": "ALK fusions phosphorylate FRS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43648", "l": "H(+) + hexadecanoyl-CoA + malonyl-[ACP] = 3-oxooctadecanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805276", "l": "CDK5 phosphorylates TP53 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64635", "l": "acetyl-CoA + butan-1-ol <=> butyl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696183", "l": "AOC3 deaminates BZAM (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24328", "l": "7,8-dihydrofolate + ATP + formate = 10-formyldihydrofolate + ADP + phosphate"}, {"i": "EC:6.3.4.17", "l": "\"Formate--dihydrofolate ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47107", "l": "5,10-methylenetetrahydromethanopterin + glycine + H2O <=> 5,6,7,8-tetrahydromethanopterin + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51883", "l": "3,4,6-trichlorocatechol + O2 <=> (2Z,4E)-2,3,5-trichloromuconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35971", "l": "12alpha,13alpha-dihydroxyfumitremorgin C + dimethylallyl diphosphate = diphosphate + fumitremorgin B"}, {"i": "EC:2.5.1.110", "l": "\"12-alpha,13-alpha-dihydroxyfumitremorgin C prenyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16430", "l": "ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58764", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphate + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35755", "l": "NAD(+) + UDP-alpha-D-glucose = H(+) + NADH + UDP-3-oxo-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034578", "l": "limonene 8-hydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466238", "l": "BGN binds Collagen types II, III (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30953", "l": "alpha-eudesmol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856951", "l": "PP2A demethylation by PPME1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433711", "l": "Cis-homodimerization of nectins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16355", "l": "L-glutamate + sulfoacetaldehyde => 2-oxoglutarate + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57865", "l": "indole-3-carbonyl nitrile + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxy-indole-3-carbonyl nitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001002", "l": "RNA polymerase III type 1 promoter sequence-specific DNA binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001179", "l": "RNA polymerase I general transcription initiation factor binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140523", "l": "GTPase-dependent fusogenic activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653886", "l": "B4GALT1 binds LALBA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25790", "l": "pyruvate + succinate semialdehyde => 4-hydroxy-2-oxoheptanedioate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047266", "l": "poly(ribitol-phosphate) beta-glucosyltransferase activity"}, {"i": "RHEA:10068", "l": "4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose = 4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP"}, {"i": "EC:2.4.1.53", "l": "\"Poly(ribitol-phosphate) beta-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18485", "l": "6-acetyl-D-glucose + H2O = acetate + D-glucose + H(+)"}, {"i": "EC:3.1.1.33", "l": "\"6-acetylglucose deacetylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102210", "l": "rhamnogalacturonan endolyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77094", "l": "Formation of cap binding complex (CBC) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65894", "l": "H2O + xanthurenate => 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216043", "l": "Collagen type II binds integrin alpha10beta1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31279", "l": "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = (2Z,6E,10E)-geranylgeranyl diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24725", "l": "H(+) + L-methionyl(44)-[F-actin] + NADPH + O2 <=> H2O + L-methionyl(44)-(R)-S-oxide-[F-actin] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23469", "l": "2-aminobenzenesulfonate + 2 H(+) + NADH + O2 => 2,3-dihydroxybenzenesulfonate + NAD(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003922", "l": "GMP synthase (glutamine-hydrolyzing) activity"}, {"i": "RHEA:11680", "l": "ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate"}, {"i": "EC:6.3.5.2", "l": "\"GMP synthase (glutamine-hydrolyzing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49459", "l": "(2S)-2-amino-4-deoxychorismate + H2O <=> (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34718", "l": "15-methylhexadecasphing-4-enine + ATP <=> 15-methylhexadecasphing-4-enine 1-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14464", "l": "(25S)-5beta-spirostan-3beta-ol + UDP-alpha-D-glucose <=> (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9617595", "l": "SGTA binds mislocalized membrane protein (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216043", "l": "Collagen type II binds integrin alpha10beta1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43255", "l": "1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O <=> 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4837364", "l": "Secretion of SOD3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48159", "l": "ganglioside GQ1b (d18:1(4E)) + H2O <=> ganglioside GT1b (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.169", "l": "\"Protein O-GlcNAcase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725117", "l": "ALK gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49974", "l": "16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35325", "l": "(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH => (S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9652264", "l": "ERBB2 binds TKIs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27679", "l": "ATP + dCDP => ADP + dCTP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018589", "l": "di-n-butyltin dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1678843", "l": "ISGylation of protein translation regulator 4EHP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373705", "l": "Caspase cleavage of DCC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "79.682896251205548", "identifiers": [{"i": "GO:0015645", "l": "fatty acid ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54122", "l": "coelenterazine h dioxetanone => coelenterazine h + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34416", "l": "(1R,4R)-bornane-2,5-dione + FMNH2 + O2 => (1R,4R)-5-oxo-1,2-campholide + FMN + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029690", "l": "Caspase-6 translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204549", "l": "Caveolin-1 binds Basigin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48833", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10220", "l": "ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)"}, {"i": "EC:6.1.1.1", "l": "\"Tyrosine--tRNA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046964", "l": "3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity"}, {"i": "REACT:R-HSA-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65286", "l": "alpha-NeuNAc-(2->3)-beta-D-Gal-(1->3)-[alpha-NeuNAc-(2->6)]-alpha-D-GalNAc-(1<->1')-L-Thr-[protein] + CMP + H(+) => alpha-NeuNAc-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1<->1')-L-Thr-[protein] + CMP-N-acetyl-beta-neuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2172666", "l": "RB1 binds condensin II (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51099", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.n4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788611", "l": "HYKK phosphorylates 5HLYS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008046", "l": "axon guidance receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1467466", "l": "ABCA4 mediates atRAL transport (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8854303", "l": "TBC1D11 binds RAB6 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38245", "l": "1-O-eicosanyl (9Z)-octadecenoate + CoA => (9Z)-octadecenoyl-CoA + eicosan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935980", "l": "RUNX1 binds the OCLN gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64516", "l": "2-hydroxyethane-1-sulfonate + NAD(+) = H(+) + NADH + sulfoacetaldehyde"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032428", "l": "beta-N-acetylgalactosaminidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39446", "l": "(2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + NADPH <=> (11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.15"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59157", "l": "ATP + eicosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] => AMP + diphosphate + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034084", "l": "steryl deacetylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26308", "l": "2-aminophenol + O2 <=> 2-aminomuconate 6-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20837", "l": "all-trans-hexaprenyl diphosphate + isopentenyl diphosphate => all-trans-heptaprenyl diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33147", "l": "ATP + daunorubicin(in) + H2O = ADP + daunorubicin(out) + H(+) + phosphate"}, {"i": "EC:7.6.2.2", "l": "\"ABC-type xenobiotic transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19312", "l": "2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O <=> (2R)-2-O-(alpha-D-mannosyl)-glycerate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28023", "l": "ATP + holo-[ACP] + octanoate => AMP + diphosphate + octanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17490", "l": "H(+) + NADH + O2 + phthalate => cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19660", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NADP(+) <=> CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.61"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202966", "l": "Caspase mediated cleavage of HIP-55 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49098", "l": "3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine => H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627104", "l": "XIAP binds CASP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62022", "l": "(24R)-ethylcholest-5-en-3beta-ol + D-glucose => H2O + sitosteryl 3-beta-D-glucoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14581", "l": "H(+) + 2 monodehydro-L-ascorbate radical + NADH = 2 L-ascorbate + NAD(+)"}, {"i": "EC:1.6.5.4", "l": "\"Monodehydroascorbate reductase (NADH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69005", "l": "Cdc6 protein is phosphorylated by CDK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30605", "l": "AH2 + all-trans-phytofluene => 15-cis-phytoene + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55486", "l": "ent-cassa-12,15-dien-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18155", "l": "diphosphate + P(1),P(4)-bis(5'-guanosyl) tetraphosphate => 2 GTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15046", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) => (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047265", "l": "poly(glycerol-phosphate) alpha-glucosyltransferase activity"}, {"i": "MetaCyc:2.4.1.52-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428749", "l": "Activated TP receptor binds G-proten Gq (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015414", "l": "ABC-type nitrate transporter activity"}, {"i": "MetaCyc:3.6.3.26-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693111", "l": "RHOF auto-activates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64905", "l": "GTP + 2 H2O => GMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26337", "l": "L-homocysteine + S-methyl-L-methionine = H(+) + 2 L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420131", "l": "The PACAP receptor binds PACAP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51108", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072590", "l": "N-acetyl-L-aspartate-L-glutamate ligase activity"}, {"i": "REACT:R-HSA-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11627", "l": "2-(hydroxyimino)propanoate + acetone <=> acetone oxime + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855232", "l": "RELN:VLDLR binds DAB1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66671", "l": "5-methylorsellinate + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47810", "l": "epothilone B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => epothilone D + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697920", "l": "CLOCK acetylates lysine-10 of histone H3, H4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2328129", "l": "Dystroglycan binds Laminins and Dystrophin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43593", "l": "all-trans-zeaxanthin + O2 => (3R)-3-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362427", "l": "Hh-Np binds GPC5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41913", "l": "(2E)-hexadecenoyl-[ACP] + H(+) + NADPH => hexadecanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9015111", "l": "Factor Xa inhibitors binds Xa (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16690", "l": "D-glucose 6-phosphate + H2O => D-glucose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46595", "l": "alfacalcidol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> calcitriol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0019956", "l": "chemokine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851710", "l": "Aberrant alternative splicing yields a secreted FGFR2 IIIa TM disease variant (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55571", "l": "4-hydoxytryptamine 4-phosphate + 2 S-adenosyl-L-methionine <=> 2 H(+) + psilocybin + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803871", "l": "TP53 stimulates SFN expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49030", "l": "(-)-5'-demethylyatein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-bursehernin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2219524", "l": "PDPK1 binds PIP2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53758", "l": "allodeoxycholate + choloyl-CoA => allodeoxycholoyl-CoA + cholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909732", "l": "Phosphorylation of STAT2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20008", "l": "an alpha-D-glucuronoside + H2O <=> an alcohol + D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617182", "l": "PRKACA phosphorylates PLN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4411373", "l": "NLK translocates to nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507870", "l": "Aquaporins passively transport water out of cells (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23140", "l": "beta-nicotinamide D-ribonucleotide + H2O = D-ribose 5-phosphate + H(+) + nicotinamide"}, {"i": "EC:3.2.2.14", "l": "\"NMN nucleosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051721", "l": "protein phosphatase 2A binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54540", "l": "H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] = beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19912", "l": "(S)-lactate + 2 [Fe(III)cytochrome c] <=> 2 [Fe(II)cytochrome c] + 2 H(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32535", "l": "(2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O = 4-hydroxy-2-oxohexanoate"}, {"i": "EC:4.2.1.132", "l": "\"2-hydroxyhexa-2,4-dienoate hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25219", "l": "CoA + H(+) + N-acetylserotonin => acetyl-CoA + serotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18434", "l": "cyclohexylamine + H2O + O2 => cyclohexanone + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683888", "l": "LMCD1 binds GATA6, sequestering it (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187828", "l": "Translocation of p21 to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59026", "l": "dihexadecanoylglycerol + H(+) + hexadecanoate => H2O + trihexadecanoylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10167", "l": "(2R)-2-phosphoglycerate <=> H2O + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051922", "l": "cholesterol sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001859", "l": "complement component C3dg receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050514", "l": "homospermidine synthase (spermidine-specific) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46647", "l": "cortisol + H(+) + NADPH <=> 5beta-dihydrocortisol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004525", "l": "ribonuclease III activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950173", "l": "Expression of ADP-ribosylation factor 1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "75.848614326174683", "identifiers": [{"i": "GO:0019838", "l": "growth factor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35252", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O => ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161948", "l": "Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373148", "l": "succinate + CoASH + GTP <=> succinylCoA + GDP + Pi (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10015", "l": "(R)-6-hydroxynicotine + H2O + O2 <=> 6-hydroxypseudooxynicotine + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33457", "l": "CO2 + NADPH + zymosterone => 4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53363", "l": "5,6-dihydrouridine(47) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(47) in tRNA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102389", "l": "polyprenol reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482892", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961952", "l": "CDT1 gene expression is stimulated by E2F1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0052713", "l": "inositol phosphorylceramide phospholipase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14547", "l": "NH4(+) + nicotinate => H2O + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48501", "l": "H2O + octanoylglycerol => glycerol + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48105", "l": "N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine => H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34365", "l": "diphosphate + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27906", "l": "butanoyl-CoA + NADP(+) = (2E)-butenoyl-CoA + H(+) + NADPH"}, {"i": "EC:1.3.1.86", "l": "\"Crotonyl-CoA reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49134", "l": "an N(1)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine => an adenosine in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29697", "l": "cob(I)inamide(out) => cob(I)inamide(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62621", "l": "[thioredoxin]-dithiol + a hydroperoxide => [thioredoxin]-disulfide + an alcohol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28276", "l": "(R)-S-adenosyl-L-methionine => (S)-S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645535", "l": "ALPK1 phosphorylates TIFA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22147", "l": "cis-aconitate + H2O <=> D-threo-isocitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964284", "l": "BTK in active Gq-BTK complex is activated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18574", "l": "dihydrochelirubine + H(+) + O2 => chelirubine + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12043", "l": "(S)-3-(imidazol-5-yl)lactate + NADP(+) <=> 3-(imidazol-5-yl)pyruvate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1247960", "l": "Activation of p38 MAPK (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444433", "l": "Cho transports from the extracellular space to the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198270", "l": "PDPK1 phosphorylates AKT at T308 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66343", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) + ATP + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32166", "l": "ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine <=> AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54069", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O => diphosphate + sesterfisherol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614461", "l": "Tetramerization of procollagen VI (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39860", "l": "1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycerol => a triacyl-sn-glycerol + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60791", "l": "gibberellin A24 + H(+) + O2 <=> CO2 + gibberellin A9 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70494", "l": "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12495", "l": "L-methionine <=> D-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56013", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) => beta-D-mannose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14170", "l": "ATP + CoA + glutarate => ADP + glutaryl-CoA + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47287", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45610", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine => H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687107", "l": "MAPK4,6 translocate to nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015168", "l": "glycerol transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66270", "l": "AMP + H(+) + nonanoyl-CoA => CoA + nonanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35328", "l": "eicosanoyl-CoA + H(+) + malonyl-CoA => 3-oxodocosanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30066", "l": "2-demethylmenaquinol-8 + S-adenosyl-L-methionine <=> H(+) + menaquinol-8 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22734", "l": "4-methylphenol + CO2 => 4-hydroxyphenylacetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.93"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43405", "l": "N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose => H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27663", "l": "(S)-2-hydroxyglutarate + O2 => 2-oxoglutarate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38789", "l": "(9Z)-octadecenoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788622", "l": "p-Y-STATs dimerize (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683593", "l": "ATG7:ATG3:LC3 dissociates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.35", "l": "\"Histolysain\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874718", "l": "TTPA binds alpha-TOH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21258", "l": "5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate => 3-phosphoshikimate + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202245", "l": "Phosphorylation of TBSMs in LAT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701537", "l": "p-Y705, S727 STAT3 dimer binds CD274 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030269", "l": "tetrahydromethanopterin S-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867288", "l": "OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15019", "l": "an alcohol + phosphate => a phosphate monoester + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58498", "l": "glycolaldehyde + H2O + NAD(+) + trimethylamine => choline + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44643", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + ATP <=> a 2'-deoxyribonucleoside 5'-triphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917841", "l": "Acidification of Tf:TfR1 containing endosome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19149", "l": "L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide"}, {"i": "RHEA:54884", "l": "L-arginyl-[protein] + NADP(+) = H(+) + N(omega)-(2'-phospho-ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide"}, {"i": "EC:2.4.2.31", "l": "\"NAD(+)--protein-arginine ADP-ribosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173542", "l": "SMURF2 ubiquitinates SMAD2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63302", "l": "H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine => N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60141", "l": "dodecanoyl-CoA + H(+) + malonyl-CoA => 3-oxotetradecanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013435", "l": "RHOD auto-activates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.48"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201637", "l": "Caspase-mediated cleavage of plectin-1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24983", "l": "3-hydroxy-4-methylanthranilate + ATP + H(+) <=> 3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033464", "l": "GGG codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445700", "l": "Myosin Binds ATP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3341277", "l": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61630", "l": "1-piperideine + H2O => 5-aminopentanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52543", "l": "cytidine + phosphate <=> alpha-D-ribose 1-phosphate + cytosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51350", "l": "10 A + 7 CO2 + 8 CoA + dehydroprobetaenone I + 6 H2O + 5 S-adenosyl-L-homocysteine => acetyl-CoA + 10 AH2 + 2 H(+) + 7 malonyl-CoA + 5 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11393", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O => 1D-myo-inositol 1,3,4-trisphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52806", "l": "(+)-eremophilene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694442", "l": "CNIH2,3 bind GRIA1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43685", "l": "ATP + L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphate => AMP + diphosphate + H(+) + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803104", "l": "DCD forms oligomeric complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418925", "l": "ADORA2A,B bind Ade-Rib (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647994", "l": "RAS proteins are depalmitoylated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46035", "l": "H2O2 + tetradecanoate <=> (2S)-hydroxytetradecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35802", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O <=> 7,8-dihydroneopterin 3'-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16952", "l": "myo-inositol + NAD(+) <=> H(+) + NADH + scyllo-inosose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52419", "l": "3-dehydro-4-O-phospho-D-erythronate + H(+) <=> CO2 + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35291", "l": "11-methyldodecanoyl-CoA + H(+) + malonyl-CoA = 3-oxoisopentadecanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605632", "l": "Both hexosaminidase A and B can cleave GalNAc from globoside (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40333", "l": "1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+) => 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59114", "l": "ADP + H(+) + O-phospho-L-serine => ATP + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18640", "l": "H2 + NADP(+) <=> H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49565", "l": "D-sedoheptulose 7-phosphate => 2-epi-valiolone + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65005", "l": "ATP + decanoate + holo-[ACP] => AMP + decanoyl-[ACP] + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046589", "l": "ribonuclease T1 activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39746", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047362", "l": "thiosulfate-dithiol sulfurtransferase activity"}, {"i": "RHEA:15121", "l": "dithioerythritol + thiosulfate = cis-1,2-dithiane-4,5-diol + 2 H(+) + hydrogen sulfide + sulfite"}, {"i": "EC:2.8.1.5", "l": "\"Thiosulfate--dithiol sulfurtransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27685", "l": "ATP + dTDP <=> ADP + dTTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58771", "l": "1-O-(1Z-hexadecenyl)-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-O-(1Z-hexadecenyl)-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8857555", "l": "EGFR phosphorylates GPNMB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60016", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + sesquisabinene B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928640", "l": "PAKs phosphorylate MLC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14095", "l": "indole-3-pyruvate + L-glutamate => 2-oxoglutarate + L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2533965", "l": "NID1 degradation by MMP14, MMP15 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000411", "l": "RANBP2 SUMOylates PML with SUMO2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63404", "l": "3,6-dichloropyridine-2,5-diol + FADH2 + O2 = 6-chloro-3-hydroxypyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043779", "l": "cobalt-precorrin-5A acetaldehyde-lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8862300", "l": "LYZ binds bacterial peptidoglycan (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.6", "l": "\"S-alkylcysteine lyase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047505", "l": "(-)-menthol monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18866", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2-methylpropanoyl-CoA => (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[protein] + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44355", "l": "ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide C + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-112429", "l": "Formation of FACT complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33871", "l": "(S)-2-ureidoglycine + H2O = glyoxylate + NH4(+) + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694471", "l": "Polyadenylation of SARS-CoV-2 genomic RNA (plus strand) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60097", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37081", "l": "2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine => 2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38485", "l": "a 2-acylglycerol + a fatty acid + H(+) => a 2,3-diacyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38716", "l": "ATP + choline(out) + H2O => ADP + choline(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008473", "l": "ornithine cyclodeaminase activity"}, {"i": "RHEA:24368", "l": "L-ornithine = L-proline + NH4(+)"}, {"i": "EC:4.3.1.12", "l": "\"Ornithine cyclodeaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16722", "l": "5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-Glu)(n) => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102581", "l": "cyanidin 3-O-glucoside-p-coumaroyltransferase activity"}, {"i": "MetaCyc:RXN-15327"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19993", "l": "[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide"}, {"i": "EC:1.8.4.13", "l": "\"L-methionine (S)-S-oxide reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n12"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12894", "l": "prostaglandin H2 => prostaglandin E2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51942", "l": "(1Z,2S)-2-methylbutanal oxime => (1E,2S)-2-methylbutanal oxime"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421158", "l": "xanthine + H2O + NAD+ => urate + NADH + H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050243", "l": "pyruvate dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264622", "l": "Cho is acetylated to AcCho by CHAT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940100", "l": "CDK1 phosphorylates VCPIP1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16258", "l": "alpha,alpha-trehalose + phosphate => alpha-D-glucose + alpha-D-glucose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59392", "l": "acetyl-CoA + L-seryl-[protein] = CoA + O-acetyl-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627056", "l": "Procaspase 9 forms dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446391", "l": "Formation of the PINCH-ILK-parvin complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769397", "l": "SOST binds LRP5/6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22881", "l": "2-oxoglutarate + L-arogenate => L-glutamate + prephenate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103084", "l": "methylthiobutylmalate dehydrogenase activity"}, {"i": "MetaCyc:RXNQT-4168"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59271", "l": "A + H2O + N(6)-methyl-L-lysyl-[protein] <=> AH2 + formaldehyde + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222712", "l": "Nitrosoglutathione gets cleaved to Cys(NO)-Gly (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30502", "l": "H(+) + N,N-dihydroxy-L-valine <=> (E)-2-methylpropanal oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18711", "l": "AH2 + NH4(+) + sulfoacetaldehyde => A + H2O + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62877", "l": "AH2 + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate => A + semiviriditoxin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928646", "l": "EPHAs bind EFNAs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0072570", "l": "ADP-D-ribose binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57585", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] => a 2-hydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936563", "l": "ISGylation of DDX58 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51867", "l": "(2E)-geranyl diphosphate + esculetin <=> 8-geranylesculetin + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38654", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65288", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16854", "l": "N(6)-(1,2-dicarboxyethyl)-AMP => AMP + fumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49145", "l": "2-oxoglutarate + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose => dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047770", "l": "carboxylate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625196", "l": "Unfolded substrate in LAMP2a multimeric complex binds HSPA8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2317332", "l": "PIP3 recruits AKT to the membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14895", "l": "(2R,4S)-2,4-diaminopentanoate => D-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16758", "l": "NADP(+) + trypanothione => H(+) + NADPH + trypanothione disulfide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005151", "l": "interleukin-1, type II receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.44"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004176", "l": "ATP-dependent peptidase activity"}, {"i": "REACT:R-HSA-9698929", "l": "pPR-AP:pAP cleaves the MCP:pPR-AP:pAP Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52931", "l": "cyclic di-3',5'-guanylate + 2 H2O <=> 2 GMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22090", "l": "AMP + guanosine 3'-diphosphate 5'-triphosphate => ATP + GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51774", "l": "4-prenylphlorisobutanophenone + diphosphate => dimethylallyl diphosphate + phlorisobutanophenone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64317", "l": "2 dihydrogeodin + 2 H(+) + O2 => 2 (+)-geodin + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23648", "l": "dTDP-6-deoxy-beta-L-talose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH"}, {"i": "EC:1.1.1.134", "l": "\"dTDP-6-deoxy-L-talose 4-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671702", "l": "AP1G2 binds HGS and CHMP2A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41213", "l": "2-hydroxy-(1H-indol-3-yl)acetate + H2O + NAD(+) => (indol-3-yl)acetate + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879594", "l": "SLCO4C1 mediates the transport of digoxin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592371", "l": "Initial activation of proMMP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2219524", "l": "PDPK1 binds PIP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41890", "l": "(3R)-hydroxytetradecanoyl-[ACP] + NADP(+) => 3-oxotetradecanoyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31298", "l": "(2E)-2-hydroxypenta-2,4-dienoate <=> 2-oxopent-4-enoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71223", "l": "2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2984258", "l": "NEK9 phosphorylates NEK6/NEK7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944420", "l": "MAF1 binds the PTEN gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54665", "l": "(3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene => pre-alpha-onocerin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50485", "l": "acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.110", "l": "\"C5a peptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.12.-", "l": "\"Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17724", "l": "a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56042", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33527", "l": "acetyl-CoA + ergosta-5,7,22,24(28)-tetraen-3beta-ol = CoA + ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13933", "l": "all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635859", "l": "GLI:SUFU dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2186780", "l": "Degradation of Ub-SMAD7 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52943", "l": "chenodeoxycholate + UDP-alpha-D-glucuronate <=> chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2002428", "l": "Removal of fibrillar collagen N-propeptides (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987015", "l": "IL20 binds IL20RA:JAK1:IL20RB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730858", "l": "Autophosphorylation of BTK/ITK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46037", "l": "2'-deoxycytidine + UTP => dCMP + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56238", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65422", "l": "GMP(out) + NAD(+)(in) => GMP(in) + NAD(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35867", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32595", "l": "7-isopropyl-4-methyloxepan-2-one + H2O = 6-hydroxy-3,7-dimethyloctanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13994", "l": "(S)-3-amino-2-methylpropanoate + 2-oxoglutarate => 2-methyl-3-oxopropanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66551", "l": "3'-phosphoadenylyl sulfate + 4-nitrophenol <=> 4-nitrophenyl sulfate + adenosine 3',5'-bisphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785762", "l": "IL13RA1 binds TYK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50330", "l": "1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60310", "l": "2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine => L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66542", "l": "AH2 + cholesta-5,7-dien-3beta,25-diol => A + cholesta-5,7-dien-3beta-ol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17938", "l": "dihydroxyacetone phosphate => methylglyoxal + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26540", "l": "carbamoyl phosphate + 2 H2O => hydrogencarbonate + NH4(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36609", "l": "(2S,3S)-hydroxyarginine + CO2 + succinate => 2-oxoglutarate + L-arginine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40904", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => H(+) + hexadecanoate + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31836", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-3-dehydro-6-deoxy-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32707", "l": "(2E)-geranyl diphosphate = (2R,4S)-bornyl diphosphate"}, {"i": "EC:5.5.1.22", "l": "\"(-)-bornyl diphosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38392", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12279", "l": "3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55284", "l": "all-trans-retinol + tetradecanoyl-CoA = all-trans-retinyl tetradecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60088", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NADP(+) = a 4alpha-methyl-3-oxosteroid + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66860", "l": "dimethylallyl diphosphate + 4 isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28311", "l": "beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035982", "l": "Defective HEXB does not cleave the terminal GalNAc from HA fragments (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424485", "l": "Release of p-PLCG1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35861", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156699", "l": "Inactivation of Wee1 kinase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39815", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + octadecanoate = 2-hydroxyoctadecanoate + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938063", "l": "SERPINB13 gene expression is inhibited by RUNX1:CBFB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5622129", "l": "FABP5 binds atRA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47678", "l": "ADP + H(+) + N-acetyl-D-galactosamine 6-phosphate => ATP + N-acetyl-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9692880", "l": "HRH3 binds Hist (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29759", "l": "octanoate(in) = octanoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25416", "l": "AH2 + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605632", "l": "Both hexosaminidase A and B can cleave GalNAc from globoside (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10527", "l": "2-oxoglutarate + H(+) <=> CO2 + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35733", "l": "1-tetradecanoyl-sn-glycerol 3-phosphate + CoA => sn-glycerol 3-phosphate + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33244", "l": "L-tetrahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-7-(methylsulfanyl)heptanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390835", "l": "DRD1,5 bind DA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31636", "l": "beta-D-Delta(4)-GlcA-(1->4)-beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc + H2O => 5-dehydro-4-deoxy-D-glucuronate + beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30858", "l": "dammarenediol-II <=> (S)-2,3-epoxysqualene + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080100", "l": "L-glutamine:2-oxoglutarate aminotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33519", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + sphinganine = (4R)-hydroxysphinganine + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174967", "l": "NAT2 acetylation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-452108", "l": "Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653957", "l": "Rag dimer formation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875558", "l": "RAPGEF1 binds CRK,CRKL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034881", "l": "citrazinate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31876", "l": "(S)-2,3-epoxysqualene => marneral"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32120", "l": "GDP-valienol + validamine 7-phosphate => GDP + H(+) + validoxylamine A 7'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57229", "l": "GDP + glyoxal => N(2)-(1-hydroxy-2-oxoethyl)-GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782138", "l": "ERCC5 and RPA bind TC-NER site (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663120", "l": "p-BMAL1:p-CLOCK,NPAS2 binds CRY1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0004904", "l": "interferon receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56576", "l": "globoside Gb3Cer + UDP-N-acetyl-alpha-D-galactosamine = globoside Gb4Cer + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190260", "l": "FGFR2b binds to FGF (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58739", "l": "H2O + TTP <=> 5-methyl-UMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106372", "l": "primary fluorescent dioxobilin-type chlorophyll catabolite methylesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12749", "l": "3,4,5-trihydroxybenzoate + H(+) = 1,2,3-trihydroxybenzene + CO2"}, {"i": "EC:4.1.1.59", "l": "\"Gallate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51782", "l": "deoxyadlupulone + diphosphate => 4-prenylphlormethylbutanophenone + dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352840", "l": "glucose + ATP => glucose 6-phosphate + ADP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030625", "l": "U11 snRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428231", "l": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32942", "l": "a 1,2-diacyl-sn-glycerol + CDP-choline <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10174", "l": "2 (R)-3-hydroxybutanoate + H(+) => (3R)-hydroxybutanoate dimer + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928631", "l": "GIT1 binds bPIX (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853444", "l": "AURKA phosphorylates PHLDA1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350058", "l": "Formation of CSL NCOR corepressor complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.168", "l": "\"Xyloglucan 4-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15154", "l": "4-hydroxybenzoate + UDP-alpha-D-glucose => 4-(beta-D-glucosyloxy)benzoate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43834", "l": "3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate => 5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811412", "l": "Active ARF recruits coatomer to the Golgi (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102361", "l": "esculetin 4-O-beta-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50724", "l": "(E)-4-hydroxyphenylacetaldehyde oxime = (Z)-(4-hydroxyphenyl)acetaldehyde oxime"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14016", "l": "3'-phosphoadenylyl sulfate + taurolithocholate <=> adenosine 3',5'-bisphosphate + H(+) + taurolithocholate 3-sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10695", "l": "6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 <=> H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111970", "l": "PKC phosphorylates GRK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786155", "l": "POLN binds ICL-DNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043793", "l": "beta-ribofuranosylaminobenzene 5'-phosphate synthase activity"}, {"i": "MetaCyc:RXN-8124"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2428922", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25555", "l": "9alpha-copalyl diphosphate <=> diphosphate + stemar-13-ene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46098", "l": "4 CO2 + 4 CoA + dihydropinosylvin => 3-phenylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20570", "l": "H2O + L-arginine => L-ornithine + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56851", "l": "1,6-didemethyltoxoflavin + S-adenosyl-L-methionine <=> H(+) + reumycin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17234", "l": "L-fucose => L-fuculose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707690", "l": "BACH1 binds MAFK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57908", "l": "ATP + L-glutamyl-tRNA(Gln) = 5-phosphooxy-L-glutamyl-tRNA(Gln) + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047400", "l": "phosphonoacetate hydrolase activity"}, {"i": "MetaCyc:3.11.1.2-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42269", "l": "2-methylpropanoyl-CoA + H(+) + malonyl-[ACP] => 4-methyl-3-oxopentanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14188", "l": "3-phenylpyruvate + H(+) <=> 2-phenylacetaldehyde + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428750", "l": "Gq activation by TP receptor (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11416", "l": "2 1-O-galloyl-beta-D-glucose = 1,6-bis-O-galloyl-beta-D-glucose + D-glucose"}, {"i": "EC:2.3.1.90", "l": "\"Beta-glucogallin O-galloyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30690", "l": "(4R)-4-hydroxy-2-oxoglutarate <=> glyoxylate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65208", "l": "(3S)-3-hydroxybutanoyl-CoA + H2O = (S)-3-hydroxybutanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158942", "l": "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12297", "l": "deacetylipecoside + H2O => dopamine + secologanin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080062", "l": "cytokinin 9-beta-glucosyltransferase activity"}, {"i": "KEGG.REACTION:R08369"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73797", "l": "FAICAR => IMP + H2O (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62602", "l": "5-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24142", "l": "2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034860", "l": "2-mercaptobenzothiazole desulfurase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62174", "l": "an N-acylethanolamine + phosphate => an N-acylethanolamine phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15505", "l": "2-(hydroxymethyl)glutarate + NAD(+) = 2-formylglutarate + H(+) + NADH"}, {"i": "EC:1.1.1.291", "l": "\"2-hydroxymethylglutarate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428273", "l": "SPHK1 phosphorylates SPG to S1P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35058", "l": "3,6-dichlorocatechol + O2 <=> (2E,4E)-2,5-dichloromuconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45527", "l": "[C-phycocyanin alpha-subunit]-Cys(84)-phycocyanobilin <=> (2R,3E)-phycocyanobilin + apo-[C-phycocyanin alpha-subunit]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5687107", "l": "MAPK4,6 translocate to nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111883", "l": "Hydrolysis of phosphatidylcholine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018703", "l": "2,4-dichlorophenoxyacetate dehalogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47024", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O = [DsrC protein]-S-sulfo-L-cysteine/L-cysteine + 3 AH2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70486", "l": "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62366", "l": "(Z)-2-methylureidoacrylate + FMN-N(5)-oxide + 2 H(+) => FMNH2 + O2 + thymine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47855", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O <=> a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51219", "l": "3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one <=> 3beta-sulfooxy-androst-5-en-17-one + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39988", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol => all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64104", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + O-phospho-L-seryl-[protein] = 1D-myo-inositol hexakisphosphate + O-diphospho-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210444", "l": "L-Glutamate loading of synaptic vesicle (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62264", "l": "hydrogencarbonate(out) + selenite(out) + Zn(2+)(out) = hydrogencarbonate(in) + selenite(in) + Zn(2+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33787", "l": "3'-ketolactose + H2O = 3-keto-beta-D-galactose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12529", "l": "N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate => [hyaluronan](n+1) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45268", "l": "4'-hydroxyechinenone + AH2 + O2 = 4',4'-dihydroxyechinenone + A + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106262", "l": "1-acylglycerophosphoethanolamine O-acyltransferase activity"}, {"i": "RHEA:32995", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA"}, {"i": "EC:2.3.1.n7", "l": "\"1-acylglycerophosphoethanolamine O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660536", "l": "SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052910", "l": "23S rRNA (adenine(2085)-N(6))-dimethyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25724", "l": "L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63479", "l": "NADP(+) + prostaglandin E2 <=> 15-oxoprostaglandin E2 + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44876", "l": "a 1,3-diacylglycerol + H2O = 3-acyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-420688", "l": "GABAB heterodimeric receptor binds GABA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31682", "l": "O2 + prosolanapyrone II <=> H2O2 + prosolanapyrone III"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61896", "l": "betaenone C = betaenone A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6802973", "l": "PLK3 phosphorylates CDC25C (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212380", "l": "Formation of TRAP coactivator complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72621", "l": "Ribosomal scanning  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024906", "l": "BDNF binds NTRK2 (TRKB) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44674", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052681", "l": "alpha-bisabolene synthase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004430", "l": "1-phosphatidylinositol 4-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211960", "l": "CYP2U1 19-hydroxylates ARA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000247", "l": "Endosomal CBLIF:Cbl translocates to lysosome (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20246", "l": "ATP + streptomycin => 3''-O-adenylylstreptomycin + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37341", "l": "(R)-3-amino-2-methylpropanoate + CO2 + NH4(+) => 3-(carbamoylamino)-2-methylpropanoate + 2 H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043844", "l": "ADP-specific phosphofructokinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865320", "l": "CBFB binds RUNX1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29920", "l": "alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP => ADP + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.98.-", "l": "\"With other, known, acceptors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34427", "l": "(-)-lariciresinol + NADP(+) = (-)-pinoresinol + H(+) + NADPH"}, {"i": "EC:1.23.1.3", "l": "\"(-)-pinoresinol reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59113", "l": "ATP + L-serine => ADP + H(+) + O-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "ic": "81.790986234327661", "identifiers": [{"i": "GO:0061659", "l": "ubiquitin-like protein ligase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004495", "l": "mevaldate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23626", "l": "a uridine in tRNA + H(+) + NADPH => a 5,6-dihydrouridine in tRNA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047990", "l": "hydroxyglutamate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22817", "l": "D-xylose => D-xylulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61225", "l": "H2O + L-asparagine + O2 => 2-oxosuccinamate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63305", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10933", "l": "ATP + L-aspartate + L-citrulline => 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57401", "l": "3-O-acetylpapaveroxine + H2O => acetate + H(+) + narcotine hemiacetal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047588", "l": "5-aminopentanamidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53622", "l": "(-)-spiroviolene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5660665", "l": "Caspase-8 binds MALT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28249", "l": "(R)-pantoate + ATP <=> (R)-4-phosphopantoate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3814820", "l": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798257", "l": "PTPRS binds NTRK3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047039", "l": "tetrahydroxynaphthalene reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58152", "l": "H2O + NAD(+) + phosphonoacetaldehyde = 2 H(+) + NADH + phosphonoacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-507870", "l": "Aquaporins passively transport water out of cells (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56208", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] = 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14329", "l": "2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate"}, {"i": "RHEA:16573", "l": "2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate"}, {"i": "EC:2.6.1.52", "l": "\"Phosphoserine transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804724", "l": "MDM2 ubiquitinates phosphorylated MDM4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40131", "l": "(9Z)-hexadecenoyl-CoA + H2O = (9Z)-hexadecenoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13427", "l": "a pyrimidine nucleobase + D-ribose 5-phosphate => a pyrimidine ribonucleoside 5'-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19353", "l": "glycocholate + H2O = cholate + glycine"}, {"i": "EC:3.5.1.24", "l": "\"Choloylglycine hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69142", "l": "Recruitment of Dna2 endonuclease (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16222", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944454", "l": "mTORC1 phosphorylates MAF1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60033", "l": "8-oxo-GTP + H2O => 8-oxo-GDP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59868", "l": "4-(2,4-dichlorophenoxy)butanoate + ATP + L-glutamine = 4-(2,4-dichlorophenoxy)butanoyl-L-glutamine + AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001786", "l": "phosphatidylserine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34420", "l": "(+)-lariciresinol + NADP(+) => (+)-pinoresinol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30401", "l": "alpha-cryptoxanthin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => alpha-carotene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50444", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2 = prostaglandin G3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13573", "l": "[(1->4)-alpha-D-galacturonosyl](n) + UDP-alpha-D-galacturonate = [(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP"}, {"i": "EC:2.4.1.43", "l": "\"Polygalacturonate 4-alpha-galacturonosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2247511", "l": "STAB2:ligand is endocytosed (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20064", "l": "2'-deoxycytidine + a ribonucleoside 5'-triphosphate <=> a ribonucleoside 5'-diphosphate + dCMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61441", "l": "acetyl-CoA + S-(2-succino)-L-cysteine => CoA + H(+) + N-acetyl-S-(2-succino)-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41770", "l": "CMP + ganglioside GT1a (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E))"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28709", "l": "Cd(2+)(out) => Cd(2+)(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0008093", "l": "cytoskeletal anchor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37160", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51870", "l": "demethylsuberosin + diphosphate => dimethylallyl diphosphate + umbelliferone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070612", "l": "histone methyltransferase activity (H2A-R3 specific)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034905", "l": "5-chloro-4-hydroxy-2-oxopentanate aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15468", "l": "ATP + sphinganine <=> ADP + H(+) + sphinganine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51986", "l": "all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981606", "l": "Myoglobin binds oxygen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11571", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP <=> 5-methyldeoxycytidine 5'-phosphate + 7,8-dihydrofolate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6795290", "l": "TORC2 complex phosphorylates SGK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033526", "l": "USP9X binds Ub:PEX5S (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50967", "l": "cytidine(8) in tRNA + H(+) + H2O <=> NH4(+) + uridine(8) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27637", "l": "5-dehydro-D-gluconate + NADP(+) <=> 2,5-didehydro-D-gluconate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36627", "l": "2-hydroxytetracosanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxytetracosanoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "ic": "77.690207805941611", "identifiers": [{"i": "GO:0005230", "l": "extracellular ligand-gated ion channel activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047338", "l": "UTP:xylose-1-phosphate uridylyltransferase activity"}, {"i": "RHEA:18389", "l": "alpha-D-xylose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-xylose"}, {"i": "EC:2.7.7.11", "l": "\"UTP--xylose-1-phosphate uridylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798749", "l": "Exocytosis of specific granule lumen proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57532", "l": "5'-end ribonucleotide-RNA + ATP + H(+) = adenosine-5'-diphospho-5'-ribonucleotide-RNA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009485", "l": "IL34:CSF1 binds CSF1R (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-844447", "l": "NLRP1 senses MDP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51399", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + serotonin <=> CoA + H(+) + N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33410", "l": "ATP + glycine + H(+) <=> diphosphate + glycyl-5'-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54691", "l": "alliin <=> 2-aminoprop-2-enoate + allylsulfenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46779", "l": "a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.26", "l": "\"HECT-type E3 ubiquitin transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44631", "l": "L-dihydroanticapsin + NAD(+) <=> H(+) + L-anticapsin + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177926", "l": "Dephosphorylation of PAG by SHP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33273", "l": "a 1,2-diacyl-sn-glycerol + a fatty acid + H(+) => a triacyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61194", "l": "CoA + H(+) + myricetin 3-O-[(6-O-(E)-4-coumaroyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside] => (E)-4-coumaroyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209160", "l": "Activated ERKs phosphorylate ERF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30107", "l": "D-serine + NADP(+) = 2-aminomalonate semialdehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12177", "l": "phenylethanolamine + S-adenosyl-L-methionine => H(+) + N-methylphenylethanolamine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165680", "l": "Formation of active mTORC1 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433826", "l": "Phosphorylation of IRF3 by IKK epsilon(IKBKE) complexed with activated TLR3. (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019970", "l": "interleukin-11 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60348", "l": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.362", "l": "\"[Histone H4]-N-methyl-L-lysine(20) N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6793666", "l": "MDM2 translocates to the nucleus (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69152", "l": "Removal of remaining Flap (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-179417", "l": "Multiubiquitination of Nek2A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37042", "l": "5 AH2 + 2 H(+) + heme b + 4 O2 <=> 5 A + delta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693148", "l": "BCKDK phosphorylates BCKDH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35683", "l": "hexadecasphinganine + NADP(+) = 3-oxohexadecasphinganine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37333", "l": "L-alanine + L-methionine => H2O + L-methionyl-L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015419", "l": "ABC-type sulfate transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15218", "l": "ecdysone + hexadecanoyl-CoA => CoA + ecdysone hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45138", "l": "7,8-dihydroneopterin 3'-phosphate + H2O => 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047442", "l": "17-alpha-hydroxyprogesterone aldolase activity"}, {"i": "MetaCyc:4.1.2.30-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944214", "l": "Association of procollagen type I (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691154", "l": "HFE binds TFRC dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54536", "l": "a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132261", "l": "Complement factor H binds to C3b (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "75.324974028080362", "identifiers": [{"i": "GO:0034212", "l": "peptide N-acetyltransferase activity"}, {"i": "REACT:R-HSA-3371554", "l": "HSF1 acetylation at Lys80 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61182", "l": "H(+) + quercetin 3-O-beta-D-glucoside + UDP => quercetin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626223", "l": "C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27611", "l": "formate + H(+) => CO2 + H2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39110", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate <=> (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-947499", "l": "Exchange of oxygen with sulfur in MoCo (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23418", "l": "(R)-3-sulfolactate + phosphate => (2R)-O-phospho-3-sulfolactate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59359", "l": "H2O + lactobiono-1,5-lactone <=> H(+) + lactobionate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54353", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22135", "l": "ATP + D-maltose(out) + H2O <=> ADP + D-maltose(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295622", "l": "SPRY2 binds CBL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158959", "l": "urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58661", "l": "a 5'-(5'-phosphomethyl)-ribonucleoside-RNA + S-adenosyl-L-methionine => a 5'-(5'-bisphosphomethyl)-ribonucleoside-RNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9612219", "l": "ERBB4s80 binds to SRC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18266", "l": "6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD(+) => 6-oxocyclohex-1-ene-1-carbonyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57849", "l": "2-oxoglutarate + O2 + scopoletin => CO2 + fraxetin + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16070", "l": "cytidine + H(+) + H2O => NH4(+) + uridine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55406", "l": "[phosphate](n+1) + UDP => [phosphate](n) + UTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36422", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018814", "l": "RHOT1 hydrolyzes GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2399913", "l": "atRAL binds to RBP2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22629", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate => (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0016652", "l": "oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor"}, {"i": "EC:1.6.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60101", "l": "cyanidin + UDP-alpha-D-glucose => cyanidin 3-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29638", "l": "alpha-maltopentaose + H2O <=> alpha-D-glucose + alpha-maltotetraose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46131", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4beta-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42763", "l": "D-glyceraldehyde 3-phosphate + H2O + NAD(+) <=> (2R)-3-phosphoglycerate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800490", "l": "ATM phosphorylates PIDD1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43587", "l": "H2O + iminoarginine <=> 5-guanidino-2-oxopentanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53672", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphoethanolamine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56484", "l": "3 O2 + oleanolate + 3 reduced [NADPH--hemoprotein reductase] = gypsogenate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102859", "l": "1-18:1-2-18:2-phosphatidylcholine desaturase activity (SN2-18:3 forming)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35734", "l": "sn-glycerol 3-phosphate + tetradecanoyl-CoA <=> 1-tetradecanoyl-sn-glycerol 3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371554", "l": "HSF1 acetylation at Lys80 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61061", "l": "beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + UDP-alpha-D-galactose => a neolactoside nLc4Cer + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73800", "l": "SAICAR => AICAR + Fumarate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876472", "l": "NPC2 binds CHOL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25883", "l": "2 L-dopa + O2 <=> 2 3-(3,4-dihydroxyphenyl)pyruvate + 2 NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0043773", "l": "coenzyme F420-0 gamma-glutamyl ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60406", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57866", "l": "4-hydroxy-indole-3-carbonyl nitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => indole-3-carbonyl nitrile + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080109", "l": "indole-3-acetonitrile nitrile hydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21115", "l": "globoside Gb3Cer (d18:1(4E)) + H2O <=> a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-573297", "l": "TRAF6 binding to IRAK2 stimulates its oligomerizartion upon TLR7 or TLR21 stimulation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46436", "l": "(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta,4beta-dihydroxycholest-5-en-26-oate + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62106", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59479", "l": "2 AH2 + 2 ATP + benzoate + L-phenylalanine <=> 2 A + 2 AMP + 2 diphosphate + H(+) + N-benzoyl-L-phenylalaninol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034916", "l": "2-methylhexanoyl-CoA dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40076", "l": "6-amino-6-deoxyfutalosine + H(+) + H2O => futalosine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14817", "l": "4-maleylacetoacetate = 4-fumarylacetoacetate"}, {"i": "EC:5.2.1.2", "l": "\"Maleylacetoacetate isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211960", "l": "CYP2U1 19-hydroxylates ARA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13284", "l": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) <=> 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-434362", "l": "Recruitment Of Cytoplasmic Proteins To Vesicles (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29119", "l": "a ubiquinol + nitrate = a ubiquinone + H2O + nitrite"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034917", "l": "2-methylhex-2-enoyl-CoA hydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36863", "l": "(9Z)-octadecenoyl-CoA + AH2 + O2 = (9Z,12Z)-octadecadienoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59667", "l": "D-cellopentaose + O2 <=> D-cellopentaono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29429", "l": "(R)-carnitine(in) + 4-(trimethylamino)butanoate(out) => (R)-carnitine(out) + 4-(trimethylamino)butanoate(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034017", "l": "trans-2-decenoyl-acyl-carrier-protein isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34499", "l": "1-deoxypentalenate + 2 H(+) + O2 + reduced 2[4Fe-4S]-[ferredoxin] = H2O + oxidized 2[4Fe-4S]-[ferredoxin] + pentalenate"}, {"i": "EC:1.14.15.11", "l": "\"Pentalenic acid synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6799350", "l": "Exocytosis of specific granule membrane proteins (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653936", "l": "Formation of Ragulator complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804425", "l": "TP53 binds POU4F2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-947531", "l": "Molybdenum ion transfer onto molybdopterin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106141", "l": "flavin prenyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701488", "l": "Active ALK phosphorylates JAK3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57858", "l": "(E)-6-hydroxyferuloyl-CoA + CO2 + succinate => (E)-feruloyl-CoA + 2-oxoglutarate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009362", "l": "Proteasome degrades PolyUb-RUNX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.235"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53587", "l": "NAD(+) + resolvin D2 <=> 7-oxoresolvin D2 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64157", "l": "an N-(fatty acyl)-L-methionine + H2O => a fatty acid + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17303", "l": "ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] => ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653894", "l": "Expression of CHAC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981892", "l": "Active G alpha (z) binds RGS proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43241", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015488", "l": "glucuronide:cation symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170674", "l": "Dissociation of the Gi alpha:G olf complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "74.836269892493803", "identifiers": [{"i": "GO:0016298", "l": "lipase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16935", "l": "2-oxobutanoate + NH4(+) => 1-aminocyclopropane-1-carboxylate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951499", "l": "Loading of antigenic peptides on to class I MHC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16287", "l": "H(+) + L-arginine + NADH + pyruvate => D-octopine + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49178", "l": "12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine => 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50270", "l": "(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45797", "l": "(3R)-3-hydroxybutanoyl-CoA + NADP(+) => acetoacetyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624798", "l": "LBR binds KPNB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814387", "l": "CASP14 cleaves filaggrin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9630923", "l": "NFkB inhibitor binds NFkB complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46722", "l": "(2E)-hexenoyl-CoA + H2O => (3R)-hydroxyhexanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982017", "l": "Active G alpha (q) binds RGS proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769401", "l": "DKK and KRM bind LRP5/6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32974", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + 2 H2O <=> 2 a carboxylate + 2 H(+) + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004579", "l": "dolichyl-diphosphooligosaccharide-protein glycotransferase activity"}, {"i": "RHEA:22980", "l": "a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45185", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + NH4(+) => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48546", "l": "[phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine => [phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189488", "l": "UROS transforms HMB to URO3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1170539", "l": "Prolactin receptor is internalized (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29385", "l": "2'-deoxyinosine + phosphate => dIMP + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090566", "l": "protein-phosphocysteine-N,N'-diacetylchitobiose phosphotransferase system transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49412", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-colitose = alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP + H(+)"}, {"i": "EC:2.4.1.341", "l": "\"Alpha-1,2-colitosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47189", "l": "[Co(I) methylated-thiol-specific corrinoid protein] + methanethiol => [methyl-Co(III) methylated-thiol-specific corrinoid protein] + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173709", "l": "C7 binds C5b:C6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627078", "l": "XIAP binds CASP9 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61927", "l": "(2S,4R)-ketoconazole(in) + ATP + H2O <=> (2S,4R)-ketoconazole(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174967", "l": "NAT2 acetylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070012", "l": "oligopeptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444705", "l": "T1R1/T1R3 dimer is the umami taste receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031868", "l": "prostaglandin F2-alpha receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53656", "l": "(5S,6R)-dihydroxy-(7E,9E,11Z,14Z)-eicosatetraenoate + O2 = (5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-593685", "l": "Netrin-4 binds DCC/UNC5A (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189439", "l": "ALAD condenses 2 dALAs to form PBG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15938", "l": "a primary alcohol + NADP(+) => an aldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624125", "l": "Formation of the BBSome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32967", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O = a fatty acid + H(+) + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13765", "l": "bromochloromethane + H2O = bromide + chloride + formaldehyde + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446391", "l": "Formation of the PINCH-ILK-parvin complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814671", "l": "Fusion of late-endosome derived vesicles at the TGN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28797", "l": "2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416516", "l": "GRK2 sequesters activated Gq (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684323", "l": "3CLp forms a homodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658483", "l": "Defective SLC5A7 does not cotransport Cho, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3788061", "l": "Fibronectin degradation by ADAM8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.96", "l": "\"4-aminobutyrate--pyruvate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351207", "l": "Spermine  => N-acetylated spermine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862380", "l": "HSD17B13 binds lipid droplets (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693540", "l": "MRN activates ATM (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29680", "l": "formate(in) => formate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31362", "l": "FMNH2 + nitrilotriacetate + O2 <=> ammoniodiacetate + FMN + glyoxylate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611368", "l": "CaMKII and LRRC7 bind to NMDA receptors at postsynaptic density (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.58", "l": "\"Glucan 1,3-beta-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862084", "l": "PILRA,PILRB bind CD99 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48846", "l": "5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71164", "l": "homogentisate + O2 => maleylacetoacetate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50752", "l": "2 naphthalene-1,2,4,8-tetrol + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50930", "l": "(14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24627", "l": "ATP + L-threonine + tRNA(Thr) <=> AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636396", "l": "lpdC binds to CORO1A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015531", "l": "citrate:proton symporter activity"}, {"i": "RHEA:32123", "l": "citrate(in) + H(+)(in) = citrate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41990", "l": "5alpha-pregnane-3,20-dione + H(+) + NADH => 3beta-hydroxy-5alpha-pregnane-20-one + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035410", "l": "dihydrotestosterone 17-beta-dehydrogenase activity"}, {"i": "EC:1.1.1.51", "l": "\"3(or 17)-beta-hydroxysteroid dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985591", "l": "SLIT2-bound ROBO1 binds MYO9B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65140", "l": "AH2 + O2 + protoaustinoid A = A + berkeleyone A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47820", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-triphosphate + NADPH + O2 = 9-ribosyl-trans-zeatin 5'-triphosphate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004827", "l": "proline-tRNA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786155", "l": "POLN binds ICL-DNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937050", "l": "Pellino ubiquitinates hp-IRAK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17522", "l": "ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) => ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392513", "l": "Rap1 signal termination by Rap1GAPs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449058", "l": "Interleukin-1 family are secreted (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18693", "l": "H2O + penicillin = 6-aminopenicillanate + a carboxylate"}, {"i": "EC:3.5.1.11", "l": "\"Penicillin amidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33125", "l": "(R)-tetraprenyl-beta-curcumene + diphosphate => all-trans-heptaprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11714", "l": "2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => 3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23290", "l": "acetyl-CoA + H(+) + NADH => acetaldehyde + CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39416", "l": "(2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH => (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.108"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45656", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641147", "l": "DACT1 binds DVL2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9733969", "l": "Bile salts dissociate from FABP6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66839", "l": "4 O2 + preasperterpenoid A + 4 reduced [NADPH--hemoprotein reductase] <=> asperterpenoid A + 5 H(+) + 5 H2O + 4 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34374", "l": "H2O + indole-3-acetamide <=> (indol-3-yl)acetate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36018", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001162", "l": "RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212432", "l": "Formation of DRIP coactivator complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11112", "l": "H2O + isochorismate = (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate"}, {"i": "EC:3.3.2.1", "l": "\"Isochorismatase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015142", "l": "tricarboxylic acid transmembrane transporter activity"}, {"i": "REACT:R-HSA-372449", "l": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Homo sapiens)"}, {"i": "REACT:R-HSA-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33741", "l": "H2O + hexadecanal + NAD(+) => 2 H(+) + hexadecanoate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362417", "l": "Mitoferrin translocates iron from the mitochondrial intermembrane space to the mitochondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11376", "l": "(19S)-geissoschizine + NADP(+) = 4,21-dehydrogeissoschizine + NADPH"}, {"i": "EC:1.3.1.36", "l": "\"Geissoschizine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170986", "l": "Ral-GDS binds to Ras-GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16425", "l": "formaldehyde + H2O + NAD(+) = formate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.46", "l": "\"Formaldehyde dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26410", "l": "H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate"}, {"i": "EC:4.2.1.126", "l": "\"N-acetylmuramic acid 6-phosphate etherase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047920", "l": "geissoschizine dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61778", "l": "H(+) + rebaudioside M + UDP => rebaudioside D + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44147", "l": "acetyl-CoA + L-methionine <=> CoA + H(+) + N(alpha)-acetyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58625", "l": "N-dodecanoyl-(2S)-hydroxyglycine => dodecanamide + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30473", "l": "(-)-endo-alpha-bergamotene + diphosphate => (2Z,6Z)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42187", "l": "5alpha-androstane-3beta,17beta-diol + NAD(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015638", "l": "microcin transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19668", "l": "6-carboxyhexanoyl-CoA + NAD(+) <=> 6-carboxyhex-2-enoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871226", "l": "RET binds GFRA1,GFRA2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37070", "l": "[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine <=> 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32390", "l": "dihydrocarveol + NAD(+) <=> dihydrocarvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53018", "l": "chloride + glutathione disulfide + H(+) + hydroquinone => chlorohydroquinone + 2 glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55894", "l": "a 3-(all-trans-polyprenyl)benzene-1,2-diol + H2O + NADP(+) => a 2-all-trans-polyprenylphenol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33228", "l": "(E)-4-coumarate + H(+) => 4-hydroxystyrene + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35845", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + a cardiolipin => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420883", "l": "Opsins act as GEFs for G alpha-t (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2514865", "l": "cGMP dissociates from CNG channels (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672173", "l": "Autophosphorylation of PDGFRA extracellular domain dimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848939", "l": "PTK6 binds KHDRBS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12174", "l": "beta-D-fructose 6-phosphate + NH4(+) => alpha-D-glucosamine 6-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43841", "l": "26-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (3beta)-hydroxy-cholest-5-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51880", "l": "3,4,6-trichlorocatechol + O2 = (2Z,4E)-2,3,5-trichloromuconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216283", "l": "RDX binds to and ubiquitinates CI (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12583", "l": "H2O + NAD(+) + tauropine <=> H(+) + NADH + pyruvate + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-976801", "l": "Complement factor I complex formation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655827", "l": "Expression of 7-Dehydrocholesterol Reductase (DHCR7) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68960", "l": "DNA polymerase epsilon binds at the origin (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20273", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine"}, {"i": "EC:1.14.16.1", "l": "\"Phenylalanine 4-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65095", "l": "asperaculane G + O2 + reduced [NADPH--hemoprotein reductase] <=> aculene D + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58537", "l": "glycine + hexadecanoyl-CoA => CoA + H(+) + N-hexadecanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623023", "l": "AGRP gene expression is stimulated by FOXO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31040", "l": "dodecanoyl-CoA + FAD + H(+) => (2E)-dodecenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64200", "l": "an N-(fatty acyl)-L-leucine + H2O = a fatty acid + L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61597", "l": "[DsbD protein]-dithiol + [thioredoxin]-disulfide => [DsbD protein]-disulfide + [thioredoxin]-dithiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38930", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390598", "l": "Myosin Binds ATP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432897", "l": "ILK interacts with beta-1 integrin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70573", "l": "argininosuccinate <=> fumarate + arginine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10741", "l": "a secondary alcohol + NAD(+) => a ketone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034320", "l": "alcohol O-hexanoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23562", "l": "adenosylcob(III)alamin 5'-phosphate + GMP + H(+) => adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:1990782", "l": "protein tyrosine kinase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34714", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine <=> 15-methylhexadecasphing-4-enine + a fatty acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199910", "l": "MSK1 activates ATF1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2263496", "l": "Defective NAGLU does not hydrolyse Heparan sulfate chain(4) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202966", "l": "Caspase mediated cleavage of HIP-55 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047056", "l": "(S)-canadine synthase activity"}, {"i": "KEGG.REACTION:R04400"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61177", "l": "(E)-caffeoyl-CoA + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside => CoA + H(+) + quercetin 3-O-[(6-O-[(E)-caffeoyl]-beta-D-glucosyl)-(1->2)-beta-D-glucoside]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004741", "l": "[pyruvate dehydrogenase (lipoamide)] phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54444", "l": "a (2R,3S,4S)-leucoanthocyanidin + NADP(+) = a (2R,3R)-dihydroflavonol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51944", "l": "8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine = 2 H(+) + roseoflavin + 2 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.343", "l": "\"8-amino-8-demethylriboflavin N,N-dimethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102383", "l": "steviol 19-O glucosyltransferase activity"}, {"i": "MetaCyc:RXN-13520"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863973", "l": "Fusion of ERC and phagosome (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.10", "l": "\"Non-chaperonin molecular chaperone ATPase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047985", "l": "hydrogen dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141423", "l": "Binding of the MCC complex to the APC/C complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18041", "l": "2 H2O + NH4(+) + 6 oxidized [2Fe-2S]-[ferredoxin] = 8 H(+) + nitrite + 6 reduced [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.7.7.1", "l": "\"Ferredoxin--nitrite reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606839", "l": "Steryl sulfatase hydrolyses sulfate from steroid sulfates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-913675", "l": "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.5", "l": "\"Xaa-methyl-His dipeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26149", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) => 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58709", "l": "rifampicin ortho-naphthoquinone carboxamide => rifampicin para-naphthoquinone carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61862", "l": "epoxybetaenone + H2O + NADP(+) => dehydroprobetaenone I + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65256", "l": "AH2 + O2 + verruculide C = A + H2O + verruculide C epoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029454", "l": "Autophosphorylation of PAK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45384", "l": "H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57779", "l": "2-chloro-6-nitrotoluene + NADH + O2 <=> 4-chloro-3-methylcatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63212", "l": "5-amino-6-(D-ribitylamino)uracil + methylglyoxal = 5-(2-oxopropylideneamino)-6-(D-ribitylamino)uracil + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75862", "l": "Fall Back to Closed Pre-initiation Complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2870221", "l": "E-selectin binds E-selectin ligand (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56150", "l": "CoA + hexadecanoyl-sn-glycero-3-phosphocholine => hexadecanoyl-CoA + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5357445", "l": "PAK1-3 dimer disassociates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3149492", "l": "cob(II)alamin dissociates from MMACHC:MMADHC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50597", "l": "acetyl-CoA + N-terminal L-seryl-[histone H4] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H4]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607002", "l": "Activated protein C cleaves factor VIIIa (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052796", "l": "exo-alpha-(2->8)-sialidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72143", "l": "Lariat Formation and 5'-Splice Site Cleavage (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43244", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65172", "l": "(3Z,5E)-dodecadienoyl-CoA + H2O = (3Z,5E)-dodecadienoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9613497", "l": "Unwinding DNA for the nascent transcript (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37474", "l": "3-methylbutanoyl-CoA + S-adenosyl-L-methionine <=> CoA + H(+) + N-isovaleryl-L-homoserine lactone + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66407", "l": "ATP + glutathione(in) + H2O + taurocholate(in) <=> ADP + glutathione(out) + H(+) + phosphate + taurocholate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635843", "l": "GLI translocates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29271", "l": "a menaquinol + H(+) + trimethylamine N-oxide = a menaquinone + H2O + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936963", "l": "IRAK2 induces TRAF6 oligomerization (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8949580", "l": "F1Fo ATP synthase dimerizes (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043763", "l": "UTP:glucose-1-phosphate uridylyltransferase regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18709", "l": "A + H2O + taurine = AH2 + NH4(+) + sulfoacetaldehyde"}, {"i": "EC:1.4.99.2", "l": "\"Taurine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18777", "l": "an alkylmercury + H(+) = an alkane + Hg(2+)"}, {"i": "EC:4.99.1.2", "l": "\"Alkylmercury lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50164", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18661", "l": "H2O + N(5)-[1(S)-1-carboxyethyl]-L-ornithine + NADP(+) = H(+) + L-ornithine + NADPH + pyruvate"}, {"i": "EC:1.5.1.24", "l": "\"N(5)-(carboxyethyl)ornithine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15725", "l": "1,5-anhydro-D-fructose = ascopyrone M + H2O"}, {"i": "EC:4.2.1.111", "l": "\"1,5-anhydro-D-fructose dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047091", "l": "L-lysine 6-monooxygenase (NADPH) activity"}, {"i": "RHEA:23228", "l": "L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+)"}, {"i": "EC:1.14.13.59", "l": "\"L-lysine N(6)-monooxygenase (NADPH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41420", "l": "2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2 = CO2 + grixazone B + 4 H2O"}, {"i": "RHEA:41424", "l": "2 3-amino-4-hydroxybenzaldehyde + N-acetyl-L-cysteine + 2 O2 = formate + grixazone A + H(+) + 3 H2O"}, {"i": "EC:1.10.3.15", "l": "\"Grixazone synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15272", "l": "L-xylo-hex-3-ulonolactone <=> H(+) + L-ascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114552", "l": "Thrombin-activated PARs activate G12/13 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56296", "l": "2-oxo-3-sulfanylpropanoate + L-cysteinyl-[protein] = pyruvate + S-sulfanyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35573", "l": "(1'S,5'S)-5'-hydroxyaverantin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20893", "l": "butanoyl-CoA + phosphate => butanoyl phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23047", "l": "H(+) + N,N-dihydroxy-L-tyrosine <=> (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3262512", "l": "G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41085", "l": "(9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392195", "l": "Gi activation by P2Y purinoceptor 12 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.188"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57802", "l": "4-methyl-3-nitrocatechol + H(+) + NAD(+) + nitrite => 2,3-dinitrotoluene + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33553", "l": "a fatty acid + sphinganine => an N-acylsphinganine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36604", "l": "2-oxoglutarate + L-enduracididine + O2 => (3S)-3-hydroxy-L-enduracididine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38362", "l": "2 H(+) + hydrogen sulfide + sulfite + ubiquinone-10 <=> thiosulfate + ubiquinol-10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195251", "l": "Assembly of the destruction complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20130", "l": "AMP + H2O => adenine + D-ribose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64626", "l": "(2E)-geranyl acetate + CoA => (2E)-geraniol + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416516", "l": "GRK2 sequesters activated Gq (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0070739", "l": "protein-glutamic acid ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480470", "l": "Expression of ZIC3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112379", "l": "Recruitment of elongation factors to form elongation complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50652", "l": "2-(3-methylsulfanyl)propylmalate = 2-(2-methylsulfanyl)propylmaleate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36471", "l": "3,4,5-trihydroxybenzoate(out) + H(+)(out) = 3,4,5-trihydroxybenzoate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50749", "l": "H2O + juglone => naphthalene-1,2,4,8-tetrol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1606273", "l": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388900", "l": "Neurotensin receptors can bind neurotensins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48551", "l": "[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O <=> [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19716", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1015702", "l": "Expression of IFN-induced genes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098617", "l": "adenylylselenate kinase activity"}, {"i": "REACT:R-HSA-2408540", "l": "APSe is phosphorylated to PAPSe by PAPSS1,2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24691", "l": "acetate + eugenol + NADP(+) => (E)-coniferyl acetate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69152", "l": "Removal of remaining Flap (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29462", "l": "beta-alanine(in) + H(+)(in) <=> beta-alanine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40619", "l": "H2O + tridodecanoylglycerol = 2,3-didodecanoyl-sn-glycerol + dodecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31555", "l": "(5S)-5-amino-3-oxohexanoate + acetyl-CoA = (3S)-3-aminobutanoyl-CoA + acetoacetate"}, {"i": "EC:2.3.1.247", "l": "\"3-keto-5-aminohexanoate cleavage enzyme\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16994", "l": "6 [Fe(III)cytochrome c] + 3 H2O + S-disulfanyl-L-cysteinyl-[SoxY protein] => 6 [Fe(II)cytochrome c] + 7 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54476", "l": "1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + dodecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9626817", "l": "PKC phosphorylates NCF1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62639", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide <=> (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.11"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008780", "l": "acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928625", "l": "PAKs autophosphorylate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58413", "l": "3 H(+) + hydrogen sulfide + L-aspartate 4-semialdehyde + reduced 2[4Fe-4S]-[ferredoxin] => H2O + L-homocysteine + oxidized 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52982", "l": "7-oxoheptanoyl-[ACP] + a fatty aldehyde + H(+) + 2 H2O + oxidized [flavodoxin] => a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964280", "l": "Active Gq binds BTK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64008", "l": "(4R)-hydroxysphinganine + hexadecanoyl-CoA = CoA + H(+) + N-hexadecanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34813", "l": "dihydrocurcumin + H(+) + NADPH => NADP(+) + tetrahydrocurcumin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160931", "l": "Disassembly of tight junctions (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24556", "l": "5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+) = 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH"}, {"i": "EC:1.3.1.65", "l": "\"5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52387", "l": "L-glutamate + O-phospho-L-serine <=> H(+) + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42609", "l": "a plastoquinone + (n+1) H(+)(in) + NADH => a plastoquinol + n H(+)(out) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018481", "l": "4-hydroxymuconic-semialdehyde dehydrogenase activity"}, {"i": "KEGG.REACTION:R05236"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102299", "l": "linolenate 9R-lipoxygenase activity"}, {"i": "RHEA:31687", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44338", "l": "ADP + H(+) + L-arginyl-L-alpha-amino acid + phosphate => an L-alpha-amino acid + ATP + L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55669", "l": "11-cis-retinol--[retinol-binding protein] + NAD(+) => 11-cis-retinal--[retinol-binding protein] + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16108", "l": "a (3S)-3-hydroxyacyl-CoA <=> a (2E)-enoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31104", "l": "7,8-dihydrofolate + NADP(+) => folate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66159", "l": "butanoyl-CoA + tyramine <=> CoA + H(+) + N-butanoyltyramine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30911", "l": "a sphingomyelin + H2O = a carboxylate + sphing-4-enine-phosphocholine"}, {"i": "RHEA:30915", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = a fatty acid + beta-D-glucosyl-(1<->1)-sphing-4-enine"}, {"i": "EC:3.5.1.109", "l": "\"Sphingomyelin deacylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48413", "l": "globoside IV3GalNAc-Gb4Cer + H2O => globoside Gb4Cer + N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50969", "l": "adenosine(37) in tRNA(Ala) + H(+) + H2O => inosine(37) in tRNA(Ala) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5633460", "l": "MDM2 binds TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982778", "l": "Growth hormone binds the growth hormone receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418904", "l": "A1 and A3 receptors bind adenosine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691131", "l": "CANDI binds CUL1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39424", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA => (2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36708", "l": "O-ureido-L-serine => O-ureido-D-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25524", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = 9alpha-copalyl diphosphate"}, {"i": "EC:5.5.1.14", "l": "\"Syn-copalyl-diphosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018716", "l": "1-phenanthrol glycosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682020", "l": "MRN complex binds shortened telomeres (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20933", "l": "L-erythrulose 1-phosphate => dihydroxyacetone phosphate + formaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66199", "l": "acetyl-CoA + tryptamine <=> CoA + H(+) + N-acetyltryptamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5323526", "l": "FRAT proteins bind GSK3beta (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174959", "l": "The acetyl group from acetyl-CoA is transferred to the NAT1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.4.1", "l": "\"Ribonucleoside-diphosphate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65844", "l": "ADP(out) + phosphate(in) = ADP(in) + phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0005539", "l": "glycosaminoglycan binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011958", "l": "miR-26A and B bind to the 3'UTR of the GREB1 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23923", "l": "(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22445", "l": "(E)-coniferol + NADP(+) => (E)-coniferaldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29997", "l": "ADP + H(+) + phosphate + putrescine(in) => ATP + H2O + putrescine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47369", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64345", "l": "4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + H(+) + NADPH + O2 => 2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23391", "l": "ATP + hygromycin B <=> 7''-O-phosphohygromycin B + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169192", "l": "PTP1B dephosphorylates GHR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051392", "l": "tRNA N-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38809", "l": "1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10940", "l": "(2E)-geranyl diphosphate = (4R)-limonene + diphosphate"}, {"i": "EC:4.2.3.20", "l": "\"(R)-limonene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65198", "l": "H(+) + NADH + NH4(+) + S-(acetaldehyde)-L-cysteine => H2O + NAD(+) + S-(2-aminoethyl)-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624949", "l": "Assembly of the anterograde IFT train (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.222", "l": "\"2-polyprenyl-6-hydroxyphenol methylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607736", "l": "MALT1 oligomerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013143", "l": "RAC1 GEFs activate RAC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39582", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA <=> (2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790025", "l": "Expression of BCL2, BCL2L1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033939", "l": "xylan alpha-1,2-glucuronosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977629", "l": "Displacement of C2a/Bb by CR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008892", "l": "guanine deaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5444511", "l": "Formation of MSH2:MSH3 Complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0032038", "l": "myosin II heavy chain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3878123", "l": "Initiation of SAHF formation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30153", "l": "FAD + 2 H(+) + NADPH => FADH2 + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46702", "l": "(R)-lipoyl-GMP + diphosphate => (R)-lipoate + GTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25548", "l": "(+)-copalyl diphosphate = abieta-8(14),12-diene + diphosphate"}, {"i": "EC:4.2.3.32", "l": "\"Levopimaradiene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430311", "l": "Rsu-1 interacts with Pinch1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052775", "l": "endo-1,3-alpha-L-rhamnosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36282", "l": "H(+) + NADH + O2 + theophylline <=> 3-methylxanthine + formaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0016675", "l": "oxidoreductase activity, acting on a heme group of donors"}, {"i": "EC:1.9.-.-", "l": "\"Acting on a heme group of donors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76416", "l": "Benzene is hydroxylated to phenol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848436", "l": "PTK6 phosphorylates CDKN1B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862300", "l": "LYZ binds bacterial peptidoglycan (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72619", "l": "eIF2:GTP is hydrolyzed, eIFs are released  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13552", "l": "beta-L-fucose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379848", "l": "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2314686", "l": "Aspirin acetylates PTGS2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36021", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645535", "l": "ALPK1 phosphorylates TIFA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687097", "l": "p-S857 NCOA3 binds ETV4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49863", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005308", "l": "creatine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35557", "l": "4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] + pulcherriminic acid => cyclo(L-leucyl-L-leucyl) + 4 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37407", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964284", "l": "BTK in active Gq-BTK complex is activated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10357", "l": "3alpha-hydroxy-5beta-androstan-17-one + NAD(+) => 5beta-androstane-3,17-dione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22917", "l": "4'-hydroxyacetophenone + H(+) + NADPH + O2 => 4-acetoxyphenol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65015", "l": "decanoyl-AMP + holo-[ACP] <=> AMP + decanoyl-[ACP] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29668", "l": "H2O(in) => H2O(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112342", "l": "Inactivation of MAP2K1 by CDK1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784204", "l": "JAKs bind OSMR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13748", "l": "ascopyrone M <=> microthecin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57235", "l": "GDP + methylglyoxal <=> N(2)-(1-hydroxy-2-oxopropyl)-GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11382", "l": "[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + CO2 + succinate => 2-oxoglutarate + [2-(trimethylamino)ethyl]phosphonate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65910", "l": "H2O + L-alanine + xanthurenate => 3-hydroxy-L-kynurenine + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28697", "l": "hydrogencarbonate(out) => hydrogencarbonate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55023", "l": "5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O <=> 5,6-diaminouracil + D-ribose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801675", "l": "PLK2 phosphorylates NPM1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66858", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate => (2E)-geranyl diphosphate + 3 isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41560", "l": "(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FADH2 + O2 = (3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FAD + H(+) + H2O"}, {"i": "EC:1.14.14.15", "l": "\"(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33020", "l": "(3S)-3,6-diaminohexanoate + acetyl-CoA => (3S)-6-acetamido-3-aminohexanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362485", "l": "GHBP binds GH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33521", "l": "(4R)-hydroxysphinganine + 2 [Fe(III)-cytochrome b5] + H2O => 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983156", "l": "Polyubiquitination of substrate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52690", "l": "3-phenylpyruvate + H(+) + NADH => 3-phenyllactate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3777129", "l": "HDAC3 containing complexes deacetylate histone (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64848", "l": "(3Z)-hex-3-en-1-ol + benzoyl-CoA = (3Z)-hex-3-en-1-yl benzoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65432", "l": "a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380949", "l": "AMPK is dephosphorylated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41123", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41979", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) <=> CMP + ganglioside GQ1b alpha (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28179", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate => colnelenate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26411", "l": "H2O + N-acetyl-D-muramate 6-phosphate => (R)-lactate + N-acetyl-D-glucosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5671772", "l": "p-T38-PPP1R14A binds MLCP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37731", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917841", "l": "Acidification of Tf:TfR1 containing endosome (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36760", "l": "N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine => alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65209", "l": "(3S)-3-hydroxybutanoyl-CoA + H2O => (S)-3-hydroxybutanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8943279", "l": "GGT dimers hydrolyse GSH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018766", "l": "RHOU binds effectors at the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52560", "l": "2-dehydro-D-erythronate = 3-dehydro-D-erythronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654651", "l": "Activated FGFR4 binds FRS3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10155", "l": "ATP + hydrogencarbonate + NH4(+) <=> ADP + carbamoyl phosphate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37800", "l": "2 H(+) + 2 NADH + O2 => 2 H2O + 2 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28135", "l": "(2S)-hesperidin + H2O => (2S)-hesperetin + rutinose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.93", "l": "\"Proprotein convertase 1\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018740", "l": "2'-hydroxybiphenyl-2-sulfinate desulfinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9604308", "l": "NICD4 traffics to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63786", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35246", "l": "ADP + H(+) + thiamine diphosphate <=> adenosine thiamine triphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033705", "l": "GDP-4-dehydro-6-deoxy-D-mannose reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912734", "l": "CBL:CRKL binds RAPGEF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26561", "l": "(3S)-3-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34064", "l": "2-deoxystreptamine + UDP-alpha-D-glucose => 2'-deamino-2'-hydroxyparomamine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13132", "l": "cis-4-coumarate + UDP-alpha-D-glucose <=> 4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171122", "l": "LDL + LDLR => LDL:LDLR complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31442", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-longipinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046659", "l": "digestive hormone activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31376", "l": "H(+) + pyrrole-2-carboxylate => 1H-pyrrole + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29994", "l": "H(+)(in) + L-lyxose(in) <=> H(+)(out) + L-lyxose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35111", "l": "2-dehydro-L-idonate + NADP(+) = 2,5-didehydro-D-gluconate + H(+) + NADPH"}, {"i": "EC:1.1.1.346", "l": "\"2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65489", "l": "3 ATP => 2',3',3'-c-tri-AMP + 3 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001734", "l": "mRNA (N6-adenosine)-methyltransferase activity"}, {"i": "REACT:R-HSA-72095", "l": "Internal Methylation of mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22701", "l": "gibberellin A12 aldehyde + O2 + reduced [NADPH--hemoprotein reductase] => gibberellin A12 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392834", "l": "Activation of EPACs by cAMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671702", "l": "AP1G2 binds HGS and CHMP2A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45595", "l": "H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017178", "l": "diphthine-ammonia ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976801", "l": "Complement factor I complex formation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31082", "l": "3-hydroxyisovaleryl-CoA <=> 3-methyl-(2E)-butenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65337", "l": "chrodrimanin T + H(+) + NADPH + O2 => chrodrimanin A + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637764", "l": "Binding of GRB2:GAB1 complex to p-EGFRvIII mutant (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31065", "l": "3-methyl-(2E)-butenoyl-CoA + FADH2 => 3-methylbutanoyl-CoA + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.29", "l": "\"Phycobiliprotein cysteine-84 phycobilin lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62152", "l": "dGMP + dTTP = dGDP + dTDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981931", "l": "RAC1 and CDC42 activate PAK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42155", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acyl-(4R)-4-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57904", "l": "2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + O2 = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021068", "l": "PalmS-ESRs bind CAVs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030623", "l": "U5 snRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14128", "l": "2 raffinose <=> 1(F)-alpha-D-galactosylraffinose + sucrose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20302", "l": "ATP + L-arginine + tRNA(Arg) => AMP + diphosphate + L-arginyl-tRNA(Arg)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102360", "l": "daphnetin 3-O-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-13452"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018601", "l": "4-nitrophenol 2-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31151", "l": "H2O + L-selenocystathionine = 2-oxobutanoate + L-selenocysteine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32465", "l": "2 H(+) + N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine => glycine + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977371", "l": "Factor I inactivates Factor H-boundC3b (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004569", "l": "glycoprotein endo-alpha-1,2-mannosidase activity"}, {"i": "MetaCyc:3.2.1.130-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186780", "l": "PI3-kinase binds to the active receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36939", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + tetradecanoyl-CoA = (9Z)-tetradecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17689", "l": "3'-phosphoadenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate + H(+)"}, {"i": "EC:2.8.2.34", "l": "\"Glycochenodeoxycholate sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030603", "l": "oxaloacetase activity"}, {"i": "RHEA:24432", "l": "H2O + oxaloacetate = acetate + H(+) + oxalate"}, {"i": "EC:3.7.1.1", "l": "\"Oxaloacetase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55715", "l": "(S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + (S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38009", "l": "6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine => 6-geranylgeranyl-2-methylbenzene-1,4-diol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11746", "l": "H(+) + phosphate + thiamine diphosphate => H2O + thiamine triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21093", "l": "12-hydroxydihydrochelirubine + S-adenosyl-L-methionine => dihydromacarpine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43967", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA <=> 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54644", "l": "trans-4-hydroxy-L-proline = (S)-1-pyrroline-5-carboxylate + H(+) + H2O"}, {"i": "EC:4.2.1.172", "l": "\"Trans-4-hydroxy-L-proline dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205649", "l": "p62 links damaged mitochondria to LC3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0047952", "l": "glycerol-3-phosphate dehydrogenase [NAD(P)+] activity"}, {"i": "EC:1.1.1.94", "l": "\"Glycerol-3-phosphate dehydrogenase (NAD(P)(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170149", "l": "Translocation of active Cdc25C to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22804", "l": "(6S,9R)-vomifoliol + NAD(+) = (6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH"}, {"i": "EC:1.1.1.221", "l": "\"Vomifoliol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381537", "l": "PAPP-A2 proteolyzes IGF:IGFBP5:ALS (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26014", "l": "3,7-dideoxy-D-threo-hepto-2,6-diuolosonate = 3-dehydroquinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696267", "l": "RND3 binds GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59460", "l": "hexadecan-1-ol + NADP(+) = H(+) + hexadecanal + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41964", "l": "butanoyl-CoA + O2 = (2E)-butenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983707", "l": "SYK autophosphorylates at the activated BCR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006323", "l": "Phospho-JAK2 phosphorylates EPOR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24378", "l": "AMP + diphosphate + H(+) + holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] => apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37574", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine <=> 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22041", "l": "H2O + N-formyl-L-aspartate => formate + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60755", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-jasmololone <=> CoA + jasmolin I"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015319", "l": "sodium:inorganic phosphate symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38466", "l": "a 1-acyl-sn-glycerol + an acyl-CoA <=> a 1,2-diacyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16274", "l": "an N-acylsphing-4-enine + CDP-choline => a sphingomyelin + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20738", "l": "(2S)-2-amino-3-oxobutanoate + CoA => acetyl-CoA + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983194", "l": "Kinesin-1 is a heterotetramer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23945", "l": "(E)-coniferol + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-trans-coniferol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376119", "l": "Interaction of Bnip-2 with Cdc42 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953111", "l": "E2F6 binds TFDP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446870", "l": "Polyubiquitinated TRAF6 binds the TAK1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28657", "l": "glutathione + H(+) + sulfite => glutathione S,S-dioxide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58382", "l": "H(+) + NADPH + nonanal => NADP(+) + nonan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48188", "l": "(9Z,12Z)-octadecadienoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21305", "l": "ent-kaur-16-en-19-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624494", "l": "RAF1 binds p21 RAS:GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070906", "l": "aspartate:alanine antiporter activity"}, {"i": "RHEA:33139", "l": "L-alanine(out) + L-aspartate(in) = L-alanine(in) + L-aspartate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63976", "l": "A + dihydropyriculariol = AH2 + pyriculariol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868071", "l": "Clathrin recruits PIK3C2A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047526", "l": "2'-hydroxyisoflavone reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24928", "l": "H2O + L-cystine => NH4(+) + pyruvate + S-sulfanyl-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428625", "l": "Vesicular inhibitory amino acid transport (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30509", "l": "2-demethylmenaquinol-8 + NAD(+) => 2-demethylmenaquinone-8 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60211", "l": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 <=> 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3858489", "l": "ppDVL binds DAAM1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609744", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2B (GRIN2B) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797974", "l": "LRRTMs bind NRXNs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875661", "l": "GGA3 associates with activated MET receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63275", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 <=> 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50777", "l": "hexanal + NADP(+) => (E)-hex--2-enal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41258", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10878", "l": "CO2 + phenol => 4-hydroxybenzoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41396", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine = 1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483186", "l": "PC is converted to PS by PTDSS1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69127", "l": "Formation of the Flap Intermediate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13399", "l": "2 H(+) + hexanedioate + NADPH => 6-oxohexanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10604", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine"}, {"i": "EC:3.1.4.3", "l": "\"Phospholipase C\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14947", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17538", "l": "(R)-carnitinamide + H2O => (R)-carnitine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374173", "l": "AGT(34-41) binds to AGTR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66057", "l": "indole-3-pyruvate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810357", "l": "Fillagrin and keratin intermediate filaments polymerise forming a network (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685011", "l": "ATR activation at DNA DSBs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41376", "l": "1-O-decyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-decyl-sn-glycero-3-phosphocholine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40794", "l": "H2O + hexacosanoyl-CoA <=> CoA + H(+) + hexacosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102116", "l": "laurate hydroxylase activity"}, {"i": "MetaCyc:RXN-11340"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442387", "l": "ZIP8 mediates zinc influx into cells (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17757", "l": "H(+) + L-methionine = 3-(methylsulfanyl)propanamine + CO2"}, {"i": "EC:4.1.1.57", "l": "\"Methionine decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102187", "l": "4alpha-carboxy,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol dehydrogenase/C4-decarboxylase activity"}, {"i": "MetaCyc:RXN-11949"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694428", "l": "LMAN family proteins bind glycosylated cargo (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052600", "l": "propane-1,3-diamine oxidase activity"}, {"i": "RHEA:30895", "l": "H2O + O2 + propane-1,3-diamine = 3-aminopropanal + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43464", "l": "H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018614", "l": "ethylbenzene dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9617595", "l": "SGTA binds mislocalized membrane protein (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21272", "l": "ATP + glutathione + spermidine = ADP + glutathionylspermidine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.47", "l": "\"Dihydromethanopterin reductase (NAD(P)(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44180", "l": "2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59904", "l": "H2O + NADP(+) + octanal = 2 H(+) + NADPH + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9674531", "l": "AAMP binds EGFR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4332356", "l": "CAMK2 binds MAP3K7 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687458", "l": "HSV1 RIR1 binds CASP8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60445", "l": "an S-substituted L-cysteinylglycine + H2O => an S-substituted L-cysteine + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64886", "l": "(6S)-5,6,7,8-tetrahydrofolate + 5-methyl-UMP + NADP(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36539", "l": "hexadecanoyl-CoA + sphinganine = CoA + H(+) + N-hexadecanoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62646", "l": "(5S)-hydroperoxy-(6E,8Z)-eicosadienoate => (5Z,8Z)-eicosadienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12656", "l": "(S)-malate + NAD(+) <=> CO2 + NADH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23009", "l": "alpha,alpha-trehalose 6-phosphate + H2O => D-glucose + D-glucose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43598", "l": "3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde => (3R)-3-hydroxy-8'-apo-beta-carotenal + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8870461", "l": "RABGGTA and RABGGTB bind (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199298", "l": "AKT phosphorylates CREB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371590", "l": "HSP70 binds to HSP40:nascent protein (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214395", "l": "Monomeric PGN bound PGRP-LE oligomerises in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34433", "l": "(-)-lariciresinol + H(+) + NADPH => (+)-secoisolariciresinol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15958", "l": "D-altronate => 2-dehydro-3-deoxy-D-gluconate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35088", "l": "H2O + N'-monoacetylchitobiose-6'-phosphate => D-glucosamine + N-acetyl-D-glucosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30357", "l": "a quinone + H2O + methanol => a quinol + methane + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48675", "l": "20-oxo-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426032", "l": "DAG is metabolized by DAGL to 2-AG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49548", "l": "H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] = H(+) + L-arginyl-[protein] + lactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875816", "l": "STAT3 binds activated MET receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14259", "l": "a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+) => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53098", "l": "4-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine => 4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47769", "l": "guanosine(2270) in 21S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(2270) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44595", "l": "3-(all-trans-heptaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-heptaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47150", "l": "1,3,7-trimethylurate + a ubiquinol => a ubiquinone + caffeine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130731", "l": "Formation of COPII vesicle (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9005980", "l": "IL21 binds IL21R:JAK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191299", "l": "Squalene is oxidized to its epoxide (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54975", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-[ACP] <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112436", "l": "Formation of Elongin complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2327746", "l": "FN1 aggregation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46651", "l": "17-hydroxy-3-oxochol-4-en-22-oyl-CoA <=> androst-4-ene-3,17-dione + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10951", "l": "ATP + D-glucosamine <=> ADP + D-glucosamine 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56957", "l": "ITP + pyruvate => H(+) + IDP + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202164", "l": "Translocation of PDK1 to Plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33119", "l": "(2E,6E)-farnesyl diphosphate = (+)-sativene + diphosphate"}, {"i": "EC:4.2.3.129", "l": "\"(+)-sativene synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005119", "l": "smoothened binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209536", "l": "IkB is ubiquitinated and degraded (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41562", "l": "(3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FAD + H(+) + H2O => (3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FADH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66403", "l": "ATP + glutathione(in) + glycocholate(in) + H2O <=> ADP + glutathione(out) + glycocholate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483174", "l": "PE is methylated to PC by PEMT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49953", "l": "(10aS)-10,10a-dihydrophenazine-1-carboxylate => 5,10-dihydrophenazine 1-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010541", "l": "ISL1 binds the SLIT2 gene enhancer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61096", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] = (S)-eriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070330", "l": "aromatase activity"}, {"i": "RHEA:17149", "l": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.1", "l": "\"Unspecific monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28358", "l": "FAD + H(+) + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39770", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047034", "l": "15-hydroxyicosatetraenoate dehydrogenase activity"}, {"i": "RHEA:23260", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH"}, {"i": "RHEA:23264", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NADP(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADPH"}, {"i": "EC:1.1.1.232", "l": "\"15-hydroxyicosatetraenoate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30491", "l": "L-valine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30410", "l": "hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin] <=> oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202731", "l": "JAM3 dimerises (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.n2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981665", "l": "C4b binding protein binds Protein S (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20505", "l": "an alpha-(gamma-L-glutamyl)-L-amino acid = 5-oxo-L-proline + an L-alpha-amino acid"}, {"i": "EC:4.3.2.9", "l": "\"Gamma-glutamylcyclotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57563", "l": "(+)-cis-trans-nepetalactol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 7-deoxyloganetate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353298", "l": "Removal of repair proteins and ligation of the processed ends of the DNA double-strand break (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41071", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033409", "l": "UAU codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.11", "l": "\"Neprilysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719354", "l": "Defective DPM3 does not transfer mannose to DOLP to form DOLPman (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848939", "l": "PTK6 binds KHDRBS1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201622", "l": "Caspase-mediated cleavage of gelsolin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192061", "l": "CYP46A1 24-hydroxylates CHOL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29703", "l": "L-valine(in) = L-valine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65647", "l": "(4R)-hydroxysphing-(8E)-enine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8E)-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21527", "l": "3-methyl-2-oxobutanoate + acetyl-CoA + H2O <=> (2S)-2-isopropylmalate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40682", "l": "(9Z)-octadecen-1-ol + 1-hexadecanoylglycerone 3-phosphate <=> 1-O-(9Z)-octadecenylglycerone 3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23754", "l": "ADP + all-trans-undecaprenyl phosphate + H(+) => all-trans-undecaprenol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382054", "l": "PDGF binds to extracellular matrix proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692809", "l": "CDC42 binds effectors at the ER membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018794", "l": "RHOV binds effectors at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21546", "l": "(2E,6E)-farnesyl triphosphate + ADP => (2E,6E)-farnesyl diphosphate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53485", "l": "androst-4-ene-3,11,17-trione + H(+) + NADPH => 17beta-hydroxyandrost-4-ene-3,11-dione + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050133", "l": "N6-hydroxylysine O-acetyltransferase activity"}, {"i": "MetaCyc:N6-HYDROXYLYSINE-O-ACETYLTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40205", "l": "14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13462", "l": "3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + H(+) + NADPH + O2 => 2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36433", "l": "2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase => a purine 2'-deoxy-D-ribonucleoside + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451283", "l": "kainate receptor binds glutamate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371422", "l": "ATP hydrolysis by HSP70 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070594", "l": "juvenile hormone response element binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428127", "l": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869683", "l": "oxPL binds LBP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021609", "l": "ESR-associated SRC autophosphorylates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14949", "l": "A + H2O + quinoline-4-carboxylate = 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2"}, {"i": "EC:1.3.99.19", "l": "\"Quinoline-4-carboxylate 2-oxidoreductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202500", "l": "Activation of IKK complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65950", "l": "A + a N(6)-methylcarbamoyl-2'-deoxyadenosine in DNA + CoA + H(+) + 2 H2O => a 2'-deoxyadenosine in DNA + acetyl-CoA + AH2 + NH4(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700171", "l": "Active ALK phosphorylates PLCG1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103101", "l": "UDP-glucose:7-methylthioheptylhydroximate S-glucosyltransferase activity"}, {"i": "MetaCyc:RXNQT-4326"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16717", "l": "deoxycholate + FAD + H(+) + H2O = cholate + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38477", "l": "H(+) + N(alpha)-methyl-L-histidine + S-adenosyl-L-homocysteine => L-histidine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371467", "l": "SIRT1 deacetylates HSF1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913360", "l": "GM-CSF receptor alpha subunit binds GM-CSF (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76500", "l": "TBXAS1 isomerises PGH2 to TXA2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41316", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41573", "l": "lipoxin A4 + NAD(+) => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507719", "l": "p62:MEKK3 binds to TRAF6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654399", "l": "Activated FGFR2 binds FRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47971", "l": "ganglioside GM2 + H2O <=> ganglioside GM3 + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49635", "l": "(2E,6E)-farnesyl diphosphate + 3,5-dimethylorsellinate <=> (3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48641", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) => 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52131", "l": "adenosine-5'-diphospho-5'-(DNA) + H2O <=> AMP + 2 H(+) + phospho-5'-(DNA)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004056", "l": "argininosuccinate lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10674", "l": "a thymidine dimer in DNA => cyclobutadithymidine in DNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54812", "l": "(+)-7-isojasmonate + ATP + L-isoleucine = AMP + diphosphate + H(+) + L-isoleucine-(+)-7-isojasmonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31561", "l": "H(+) + L-galactono-1,4-lactone + NADH => L-galactose + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19205", "l": "dCTP + 2 H2O = diphosphate + dUMP + NH4(+)"}, {"i": "EC:3.5.4.30", "l": "\"dCTP deaminase (dUMP-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617485", "l": "HOXB2 mRNA is translated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16681", "l": "4-hydroxyphenylacetate + H(+) + NADH + O2 = 3,4-dihydroxyphenylacetate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29196", "l": "(S)-dihydroorotate + a menaquinone => a menaquinol + orotate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34717", "l": "15-methylhexadecasphing-4-enine 1-phosphate + ADP + H(+) => 15-methylhexadecasphing-4-enine + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26400", "l": "all-trans-zeaxanthin + 2 O2 <=> 2 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21067", "l": "[protein]-disulfide + 2 glutathione <=> [protein]-dithiol + glutathione disulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21942", "l": "(S)-2,3-epoxysqualene + A + H2O => AH2 + O2 + squalene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28405", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A <=> ADP + H(+) + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31332", "l": "ATP + H(+) + molybdopterin => adenylyl-molybdopterin + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19120", "l": "dopamine + 2 L-ascorbate + O2 <=> (R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-195275", "l": "Phosphorylation of APC component of the destruction complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051500", "l": "D-tyrosyl-tRNA(Tyr) deacylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000122", "l": "CD320 transports extracellular TCII:Cbl to endosome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5627775", "l": "Autophosphorylation of PAK1,2,3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37935", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28718", "l": "(R)-malate(in) + 2 H(+)(in) <=> (R)-malate(out) + 2 H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53737", "l": "a 2-halobenzoate + H(+) + NADH + O2 => a halide anion + catechol + CO2 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53512", "l": "(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O = (13R)-S-cysteinylglycinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389532", "l": "PP2A binds CTLA4 dimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34287", "l": "2 L-dopa + O2 = 2 H2O + 2 L-dopaquinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433815", "l": "viral dsRNA : TRL3 recruits TICAM1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686088", "l": "CASP3 cleaves GSDMD (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110319", "l": "Elongation by POLH (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950741", "l": "IL12B:IL23A translocates from ER lumen to extracellular space (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23831", "l": "2-dehydro-D-gluconate + NADP(+) <=> 2,5-didehydro-D-gluconate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23518", "l": "(2R)-3-phosphoglycerate + ADP + H(+) => (R)-glycerate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-173739", "l": "Spontaneous hydrolysis of C3 thioester (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015090", "l": "low-affinity ferric iron ion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-422454", "l": "Polysialylation of NCAM1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042826", "l": "histone deacetylase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28312", "l": "alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70482", "l": "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70241", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39980", "l": "(+-)-pavine + S-adenosyl-L-methionine => H(+) + N-methylpavine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28199", "l": "(S)-1-phenylethanol + NAD(+) => acetophenone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25393", "l": "cis-3,4-dehydroadipyl-CoA + 2 H(+) + NADPH => (3Z)-6-oxohex-3-enoyl-CoA + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23148", "l": "ATP + propanoate = ADP + propanoyl phosphate"}, {"i": "EC:2.7.2.15", "l": "\"Propionate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41024", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + octadecanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-octadecanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28465", "l": "pyridoxal(in) <=> pyridoxal(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102782", "l": "cholestanol hydroxylase activity"}, {"i": "MetaCyc:RXN-7878"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59801", "l": "decanoyl-CoA + L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] => CoA + H(+) + N(6)-decanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785438", "l": "NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-377640", "l": "Autophosphorylation of SRC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15255", "l": "CO2 + itaconate => cis-aconitate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2064932", "l": "WWTR1 (TAZ) binds RUNX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41425", "l": "2 3-amino-4-hydroxybenzaldehyde + N-acetyl-L-cysteine + 2 O2 => formate + grixazone A + H(+) + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55556", "l": "a hydroperoxyeicosatetraenoate = an oxoeicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2197698", "l": "Src phosphorylate WASP,N-WASP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58774", "l": "1-O-hexadecyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-O-hexadecyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0034338", "l": "short-chain carboxylesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16438", "l": "glutathione + RX => a halide anion + an S-substituted glutathione + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57729", "l": "H(+) + trans-aconitate => CO2 + itaconate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24166", "l": "[thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein] => [thioredoxin]-disulfide + H2O + L-methionyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29471", "l": "D-ribose 5-phosphate + H2O = D-ribose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033772", "l": "flavonoid 3',5'-hydroxylase activity"}, {"i": "MetaCyc:RXN-8671"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54001", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30356", "l": "a quinol + methane + O2 => a quinone + H2O + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10199", "l": "(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate <=> 2-succinylbenzoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805061", "l": "CK2 binds FACT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051980", "l": "iron-nicotianamine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166792", "l": "Conversion of C2 into C2a and C2b (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0017111", "l": "nucleoside-triphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12155", "l": "(3R,4S,5S,6R)-pentachlorocyclohexene <=> (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60740", "l": "(S)-(-)-citronellal + H2O + NADP(+) = (S)-(-)-citronellate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010647", "l": "ROBO3.1 binds AKAP5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210426", "l": "Glutamate synaptic vesicle docking and priming (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391150", "l": "p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419351", "l": "PAF receptor binds platelet activating factor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9710354", "l": "GSDME (1-270) binds cardiolipin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8985943", "l": "p-Y701-STAT1 dimerizes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6791016", "l": "SFTPB binds itself (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31595", "l": "(Z)-2-methylureidoacrylate + H2O = (Z)-2-methylaminoacrylate + carbamate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26466", "l": "a 2-demethylmenaquinone + S-adenosyl-L-methionine = a menaquinone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805399", "l": "TAF1 phosphorylates TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694525", "l": "M protein gets N-glycosylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382096", "l": "Formation of NR-NCOR Corepressor Complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32296", "l": "2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH => 2 diphosphate + NADP(+) + squalene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42270", "l": "4-methyl-3-oxopentanoyl-[ACP] + CO2 + CoA => 2-methylpropanoyl-CoA + H(+) + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036382", "l": "flavin reductase (NADH) activity"}, {"i": "MetaCyc:1.5.1.36-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864105", "l": "PTPN18 binds ERBB2:EGFR heterodimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679839", "l": "RIPK1 binds ponatinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451450", "l": "Auto ubiquitination of oligo TRAF6 bound to p-IRAK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624951", "l": "TNPO1 binds KIF17 dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57986", "l": "(20S)-ginsenoside Rd + H(+) + UDP => (20S)-ginsenoside Rg3 + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0030554", "l": "adenyl nucleotide binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047541", "l": "2-furoate-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168136", "l": "NOTCH3 binds DLL4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52464", "l": "17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848975", "l": "PTK6 phosphorylates KHDRBS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50865", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 => 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66653", "l": "(2E,6E)-farnesyl diphosphate => african-1-ene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23341", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate => D-arabinose + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71445", "l": "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9659820", "l": "RB1 translocates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168887", "l": "Ferriheme is transferred from Albumin to Hemopexin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809354", "l": "NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29592", "l": "2-hydroxyethane-1-sulfonate + NADP(+) => H(+) + NADPH + sulfoacetaldehyde"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050340", "l": "thymidylate 5'-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47956", "l": "3-maleylpyruvate + H2O = H(+) + maleate + pyruvate"}, {"i": "EC:3.7.1.23", "l": "\"Maleylpyruvate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72124", "l": "Formation of the Spliceosomal A Complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706330", "l": "Active FLT3 binds to SOCS6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17739", "l": "3-dehydroshikimate + H(+) + NADPH => NADP(+) + shikimate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953339", "l": "DNPH1 hydrolyses dGMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58794", "l": "ADP + Fe(III)-petrobactin(in) + H(+) + phosphate => ATP + Fe(III)-petrobactin(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218822", "l": "CRK binds BCAR1 and or PXN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34034", "l": "2'-N-acetylparomamine + H2O <=> acetate + paromamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30945", "l": "(2E)-octenoyl-CoA + FADH2 => FAD + H(+) + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59030", "l": "4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O => (Z)-24-ethylidenelophenol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0016406", "l": "carnitine O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24047", "l": "3,4-dihydroxybenzoate + O2 <=> 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60117", "l": "2-oxoglutarate + methylphosphonate + O2 => CO2 + hydroxymethylphosphonate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58743", "l": "H2O + psi-UTP <=> diphosphate + H(+) + psi-UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34804", "l": "2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA => bisdemethoxycurcumin + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23598", "l": "3 H(+) + 2 NADH + UDP-alpha-D-glucuronate => H2O + 2 NAD(+) + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23976", "l": "(RNA)-3'-(3'-phosphooxy-ribonucleotide) + ATP = (RNA)-3'-(2',3'-cyclophosphooxy)-ribonucleotide + AMP + diphosphate"}, {"i": "EC:6.5.1.4", "l": "\"RNA 3'-terminal-phosphate cyclase (ATP)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31333", "l": "adenylyl-molybdopterin + diphosphate => ATP + H(+) + molybdopterin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34587", "l": "2-oxoglutarate + O2 + pentalenolactone E = CO2 + pentalenolactone F + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17800", "l": "[(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose <=> [(1->4)-beta-D-glucosyl](n+1) + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64076", "l": "3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 = 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635839", "l": "ULK3:SUFU dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420121", "l": "SFKs phosphorylate PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419426", "l": "Cannabinoid receptors can bind cannabinoids (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174255", "l": "Degradation multiubiquitinated Cyclin A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664850", "l": "ATM binds PEX5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9656244", "l": "DRD2 binds DA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213195", "l": "Formation of anchoring fibrils (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953111", "l": "E2F6 binds TFDP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936951", "l": "Activation of TAK1 complex bound to activated TLR4 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52279", "l": "(6S)-5,6,7,8-tetrahydrofolate + 4-hydroxy-3-methoxybenzoate <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4-dihydroxybenzoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28451", "l": "N(6)-(D-psicosyl)-L-lysine(in) => N(6)-(D-psicosyl)-L-lysine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381461", "l": "Plasmin proteolyzes IGF:IGFBP-3:ALS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001631", "l": "cysteinyl leukotriene receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810392", "l": "TMEM55B translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70482", "l": "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052915", "l": "23S rRNA (guanine(2445)-N(2))-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1299297", "l": "Activation of THIK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202718", "l": "Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11886", "l": "adenosine 3',5'-bisphosphate + cortisol 21-sulfate + H(+) => 3'-phosphoadenylyl sulfate + cortisol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16380", "l": "(3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin] <=> biliverdin IXalpha + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32866", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycerol <=> a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64901", "l": "H2O + UTP => H(+) + phosphate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864105", "l": "PTPN18 binds ERBB2:EGFR heterodimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029272", "l": "Release of PLCG from FCGR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73596", "l": "dCMP + H2O => dUMP + NH4+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44639", "l": "2,4-dinitroanisole + H2O <=> 2,4-dinitrophenol + H(+) + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381500", "l": "Cathepsin G proteolyzes IGF:IGFBP3:ALS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52815", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047810", "l": "D-alanine:2-oxoglutarate aminotransferase activity"}, {"i": "RHEA:15869", "l": "2-oxoglutarate + D-alanine = D-glutamate + pyruvate"}, {"i": "EC:2.6.1.21", "l": "\"D-amino-acid transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-982765", "l": "Growth hormone forms dimers and oligomers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38311", "l": "carminomycin + S-adenosyl-L-methionine = daunorubicin + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.292", "l": "\"Carminomycin 4-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791150", "l": "Expression of BIP (78 kDa Glucose-regulated protein, GRP78, HSPA5) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247849", "l": "WLS dissociates from retromer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39133", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA => 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19080", "l": "H2O + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] <=> 3-deoxyglucosone + L-lysyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14676", "l": "a polar amino acid(out) + ATP + H2O <=> a polar amino acid(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627104", "l": "XIAP binds CASP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17590", "l": "2,2'-iminodipropanoate + H2O + NAD(+) => H(+) + L-alanine + NADH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25860", "l": "GTP + H2O = 7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+)"}, {"i": "EC:3.5.4.39", "l": "\"GTP cyclohydrolase IV\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.245", "l": "\"Assimilatory dimethylsulfide S-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3229181", "l": "CALM1:Ca2+ binds CNG channel (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.71"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033771", "l": "licodione synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948136", "l": "ULK1 Translocates to the mitochondria (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11153", "l": "5-pyridoxate + NADPH + O2 => 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62333", "l": "ADP + ATP => adenosine 3'-diphosphate,5'-diphosphate + AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14348", "l": "H(+) + L-tyrosine <=> CO2 + tyramine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65058", "l": "7-oxoglycolithocholate + H(+) + NADPH => glycochenodeoxycholate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2176452", "l": "Degradation of ubiquitinated SMAD2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61136", "l": "(2R,3R)-dihydroquercetin + 2-oxoglutarate + O2 = CO2 + H(+) + H2O + quercetin + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044736", "l": "acid-sensing ion channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12585", "l": "16alpha-hydroxyprogesterone => 16,17-didehydroprogesterone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37828", "l": "(S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 => 2,4-dichlorophenol + CO2 + pyruvate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32126", "l": "citrate(in) + H(+)(in) <=> citrate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53621", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (-)-spiroviolene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26397", "l": "all-trans-zeaxanthin + 2 O2 = 2 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde"}, {"i": "EC:1.13.11.84", "l": "\"Crocetin dialdehyde synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803425", "l": "TP53 binds ZNF385A gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805470", "l": "AMPK phosphorylates TP53 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004809", "l": "tRNA (guanine-N2-)-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19166", "l": "a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose => 1,2-diacyl-3-O-[alpha-D-glucosyl-(1-> 2)-alpha-D-glucosyl]-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21831", "l": "H2O + nitrite + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2 H(+) + nitrate + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53285", "l": "NAD(+) + scyllo-inosose => 3-dehydro-scyllo-inosose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729307", "l": "Nucleoprotein is SUMOylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39810", "l": "octadecanoate(in) <=> octadecanoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607747", "l": "TRAF6 binds MALT1 oligomers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13202", "l": "glycine + L-arginine => guanidinoacetate + L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682011", "l": "LC3 binds ATG7 dimer (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61595", "l": "H2O + L-cysteinyl-[sulfatase] + S-adenosyl-L-methionine <=> 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + 2 H(+) + hydrogen sulfide + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46698", "l": "an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine => a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48233", "l": "acetyl-CoA + L-glutamate 5-semialdehyde => CoA + H(+) + N-acetyl-L-glutamate 5-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168184", "l": "Activated TAK1 mediates phosphorylation of the IKK Complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11739", "l": "2-exo-hydroxy-1,8-cineole + NAD(+) <=> 6-oxocineole + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18314", "l": "(R)-mandelonitrile => benzaldehyde + hydrogen cyanide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909721", "l": "Translocation of ISGF3 complex to nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29115", "l": "H(+) + menaquinone-8 + NADPH = menaquinol-8 + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5660663", "l": "Caspase-8 cleaves IL1B precursor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59523", "l": "ATP + butanoyl-CoA + hydrogencarbonate <=> (2S)-ethylmalonyl-CoA + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853908", "l": "VENTX stimulates CSF1R (M-CSF-R) expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29102", "l": "a menaquinone + 5 H(+)(in) + NADH <=> a menaquinol + 4 H(+)(out) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5340214", "l": "CYGB binds O2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051743", "l": "red chlorophyll catabolite reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44721", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O => a 1-acyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65239", "l": "3-methylbutanol + acetyl-CoA <=> 3-methylbutyl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948034", "l": "FGR binds LDL:LRP8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369028", "l": "ABCAs mediate lipid efflux (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37337", "l": "3-(carbamoylamino)-2-methylpropanoate + H(+) => 5,6-dihydrothymine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10941", "l": "(2E)-geranyl diphosphate => (4R)-limonene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51446", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-leucine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65772", "l": "2 H(+) + isoproturon + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1-methyl-3-[4-(propan-2-yl)phenyl]urea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10436", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O"}, {"i": "EC:4.2.1.106", "l": "\"Bile-acid 7-alpha-dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45789", "l": "(9Z)-hexadecenoyl-CoA + 1,2-dihexadecanoyl-sn-glycerol => 1,2-dihexadecanoyl-3-(9Z-hexadecenoyl)-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39397", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+) => 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60610", "l": "1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + ethanolamine => 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15827", "l": "AZD1979 oxetane hydrolysis product + H(+) => AZD1979 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0023027", "l": "MHC class I protein binding, via antigen binding groove"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20236", "l": "a 7beta-hydroxysteroid + NADP(+) <=> a 7-oxosteroid + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15362", "l": "dolichyl phosphate + UDP-alpha-D-xylose => dolichyl D-xylosyl phosphate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20795", "l": "ATP + L-lysine + tRNA(Lys) <=> AMP + diphosphate + L-lysyl-tRNA(Lys)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209840", "l": "Two DITs combine to form thyroxine (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35412", "l": "(E)-4-coumaroyl-CoA + an anthocyanidin 3-O-beta-D-glucoside => an anthocyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D--glucoside] + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39330", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA <=> (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4615910", "l": "SUMOylation of PCNA with SUMO1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034865", "l": "2,4,4-trimethylpentanoate-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46532", "l": "2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-containing glycerolipid + 2 H2O"}, {"i": "EC:1.14.19.16", "l": "\"Linoleoyl-lipid Delta(12) conjugase (11E,13Z-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013978", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61446", "l": "an 11a-hydroxytetracycline + H2O + NADP(+) => a tetracycline + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13674", "l": "[protein-PII]-L-tyrosine + UTP => [protein-PII]-uridylyl-L-tyrosine + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047176", "l": "beta-glucogallin-tetrakisgalloylglucose O-galloyltransferase activity"}, {"i": "KEGG.REACTION:R04498"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685838", "l": "CX3 complex binds D-loop structures (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63823", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) <=> H(+) + holo-[aryl-carrier protein] + petrobactin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218805", "l": "PKC autophosphorylates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877360", "l": "RUNX1 binds the IFNG promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36293", "l": "formaldehyde + H2O + NADP(+) + xanthine => 3-methylxanthine + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40920", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6795473", "l": "PDPK1 phosphorylates SGK1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59529", "l": "hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein] => CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11923", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin <=> (6R)-L-erythro-6,7-dihydrobiopterin + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047308", "l": "alanine-oxomalonate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50166", "l": "20-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16835", "l": "glutathione disulfide + 2 H2O => 2 glutathione + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5617828", "l": "TRIP11:IFT20 dissociates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45667", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209828", "l": "Tryptophan is hydroxylated (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12770", "l": "A + D-gluconate => 2-dehydro-D-gluconate + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047813", "l": "D-arabinitol 4-dehydrogenase activity"}, {"i": "RHEA:17921", "l": "D-arabinitol + NAD(+) = D-xylulose + H(+) + NADH"}, {"i": "EC:1.1.1.11", "l": "\"D-arabinitol 4-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705461", "l": "p-Y-STAT1,3,5 dimer binds SOCS1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.99.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.98.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034347", "l": "type III interferon binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15040", "l": "putrescine + S-adenosyl-L-methionine <=> H(+) + N-methylputrescine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807872", "l": "Active ARF recruits coatomer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626699", "l": "MARK4 binds ODF2 in the centriole (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814674", "l": "Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35267", "l": "ethanol(in) = ethanol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34816", "l": "2 NADP(+) + tetrahydrocurcumin => curcumin + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696670", "l": "CHD1L is recruited to GG-NER site (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424484", "l": "Phosphorylation of BTK by p-SYK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016852", "l": "sirohydrochlorin cobaltochelatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13285", "l": "ATP + L-cysteine + L-glutamate = ADP + H(+) + L-gamma-glutamyl-L-cysteine + phosphate"}, {"i": "EC:6.3.2.2", "l": "\"Glutamate--cysteine ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62245", "l": "a cytidine(6-4)thymidine in DNA => a cytidine-thymine dinucleotide in DNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18030", "l": "2 ATP + hydrogencarbonate + NH4(+) => 2 ADP + carbamoyl phosphate + 2 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005546", "l": "phosphatidylinositol-4,5-bisphosphate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218832", "l": "CDC42:GTP binds PAK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003975", "l": "UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873919", "l": "Phosphorylation of JAK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21512", "l": "3,6-anhydro-L-galactonate = 2-dehydro-3-deoxy-L-galactonate"}, {"i": "EC:5.5.1.25", "l": "\"3,6-anhydro-L-galactonate cycloisomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444433", "l": "Cho transports from the extracellular space to the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879331", "l": "glucose-6-phosphate is converted to inositol-1-phosphate (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51990", "l": "18S-resolvin E1 => (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22949", "l": "D-tagatofuranose 1,6-bisphosphate => D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66424", "l": "ATP + H2O + leukotriene B4(in) = ADP + H(+) + leukotriene B4(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797271", "l": "Expression of MAOA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15724", "l": "glycine + H2O + NAD(+) <=> glyoxylate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59119", "l": "[protein]-dithiol + O2 <=> [protein]-disulfide + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0032553", "l": "ribonucleotide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2197690", "l": "Detachment of WASP/WAVE (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30259", "l": "2 a menaquinol + O2 = 2 a menaquinone + 2 H2O"}, {"i": "EC:7.1.1.5", "l": "\"Menaquinol oxidase (H(+)-transporting)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016159", "l": "muconolactone delta-isomerase activity"}, {"i": "RHEA:12348", "l": "(S)-muconolactone = (4,5-dihydro-5-oxofuran-2-yl)-acetate"}, {"i": "EC:5.3.3.4", "l": "\"Muconolactone Delta-isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65610", "l": "CoA + H(+) + N-docosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + docosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852019", "l": "MET bound PI3K generates PIP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62365", "l": "FMNH2 + O2 + thymine => (Z)-2-methylureidoacrylate + FMN-N(5)-oxide + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40859", "l": "(9Z)-hexadecenoyl-CoA + FAD + H(+) = (2E,9Z)-hexadecadienoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.3", "l": "\"Glutamate dehydrogenase (NAD(P)(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50564", "l": "acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64533", "l": "2 [Fe(II)-cytochrome b5] + an N-(1,2 saturated very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25332", "l": "3-dehydrocarnitine + H(+) + NADH => (R)-carnitine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52799", "l": "2 H(+) + Ni-sirohydrochlorin <=> Ni(2+) + sirohydrochlorin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38884", "l": "a fatty acid + ATP + CoA => a fatty acyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803527", "l": "ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52696", "l": "a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-galactose = a 1,2-diacyl-3-O-[alpha-D-galactopyranosyl-(1->2)-alpha-D-glucopyranosyl]-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209141", "l": "ProSPZ:SPZ dimer binds to TL receptor at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047384", "l": "[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase activity"}, {"i": "MetaCyc:3.1.3.47-RXN"}, {"i": "EC:3.1.3.47", "l": "\"[Hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102161", "l": "copal-8-ol diphosphate synthase activity"}, {"i": "RHEA:32703", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = 8-hydroxycopalyl diphosphate"}, {"i": "EC:4.2.1.133", "l": "\"Copal-8-ol diphosphate hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24811", "l": "3-methyl-2-oxobutanoate + H2O => (2R)-2,3-dihydroxy-3-methylbutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936951", "l": "Activation of TAK1 complex bound to activated TLR4 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52966", "l": "H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP => hyodeoxycholate + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9667965", "l": "ANKLE2 binds PP2A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56658", "l": "12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H(+) + NADH => 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56827", "l": "AH2 + cyclooctat-9-ene-5,7-diol + O2 <=> A + cyclooctatin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18187", "l": "5'-dehydroadenosine + H2O2 => adenosine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52385", "l": "L-glutamate + O-phospho-L-serine => H(+) + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68960", "l": "DNA polymerase epsilon binds at the origin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0016663", "l": "oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor"}, {"i": "EC:1.7.3.-", "l": "\"With oxygen as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56186", "l": "globoside NOR1 + H(+) + UDP => globoside Gb4Cer + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15613", "l": "NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin"}, {"i": "EC:1.3.1.76", "l": "\"Precorrin-2 dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8873923", "l": "STARD10 binds LPCAT1 and PC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33077", "l": "6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine => 3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109862", "l": "MAP2K2 phosphorylates MAPK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69173", "l": "Joining of adjacent Okazaki fragments (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803063", "l": "RNASEs bind bacterial LPS, PGN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60239", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36479", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA = (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18839", "l": "CoA + taxuyunnanin C => 10-deacetyltaxuyunnanin C + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46493", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(in) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937369", "l": "ATAD2 binds ESR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52061", "l": "12-(9Z-octadecenoyloxy)-octadecanoate + H2O => (9Z)-octadecenoate + 12-hydroxyoctadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11831", "l": "H2O + RNA(n)-2',3'-cyclic phosphate <=> H(+) + RNA(n)-2'- phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20839", "l": "all-trans-hexaprenyl diphosphate + isopentenyl diphosphate <=> all-trans-heptaprenyl diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19272", "l": "2-furoate + ATP + CoA <=> 2-furoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13493", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31768", "l": "2-oxoglutarate + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine => L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20938", "l": "3-methyl-2-oxobutanoate + H2O => 2,3-dihydroxy-3-methylbutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33594", "l": "sphinganine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20113", "l": "beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate"}, {"i": "EC:5.4.2.6", "l": "\"Beta-phosphoglucomutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169188", "l": "SHP1 (PTPN6) dephosphorylates JAK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60082", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+) => 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11978", "l": "5a,11a-dehydrotetracycline + H2O + NADP(+) => anhydrotetracycline + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57974", "l": "eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59374", "l": "1-hexadecanoyl-sn-glycero-3-phospho-L-serine + 10-hydroxyoctadecanoate + H(+) => 1-hexadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730842", "l": "PI3K associates with phosphorylated GAB2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63396", "l": "A + Fe(II)-heme i + H2O = AH2 + Fe(II)-hydroxyheme i"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28085", "l": "(2S)-ethylmalonyl-CoA + NADP(+) <=> (2E)-butenoyl-CoA + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.19.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35386", "l": "precorrin-6B + S-adenosyl-L-methionine <=> CO2 + H(+) + precorrin-7 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13273", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol = 6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+)"}, {"i": "EC:2.8.2.19", "l": "\"Triglucosylalkylacylglycerol sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016149", "l": "translation release factor activity, codon specific"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205319", "l": "Interaction of APS and p-KIT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24841", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21351", "l": "8 H(+) + 10 malonyl-CoA <=> 10 CO2 + 10 CoA + 2 H2O + tetracenomycin F2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035599", "l": "aspartic acid methylthiotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50948", "l": "a 2'-deoxycytidine in single-stranded DNA + H(+) + H2O = a 2'-deoxyuridine in single-stranded DNA + NH4(+)"}, {"i": "EC:3.5.4.38", "l": "\"Single-stranded DNA cytosine deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36986", "l": "(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42621", "l": "(Z)-2-methylureidoacrylate + H(+) + H2O => (Z)-2-methylaminoacrylate + CO2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39134", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24112", "l": "2 glutathione + O2 = glutathione disulfide + H2O2"}, {"i": "EC:1.8.3.3", "l": "\"Glutathione oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14605", "l": "D-glucose 6-phosphate + GDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + GDP + H(+)"}, {"i": "EC:2.4.1.36", "l": "\"Alpha,alpha-trehalose-phosphate synthase (GDP-forming)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042926", "l": "3-hydroxyphenylpropionic acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22580", "l": "(S)-4-hydroxy-2-oxopentanoate = (2Z)-2-hydroxypenta-2,4-dienoate + H2O"}, {"i": "EC:4.2.1.80", "l": "\"2-oxopent-4-enoate hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983299", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32996", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40748", "l": "2-oxoglutarate + L-lysine + O2 => (3S)-3-hydroxy-L-lysine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34005", "l": "cholesta-5,7,24-trien-3beta-ol + 2 H2O + NADP(+) => 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46055", "l": "U6 RNA 3'-terminal UU <=> U6 RNA 3'-terminal uridine 2',3'-cyclic phosphate + uridine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58915", "l": "ATP + H2O + iron(III) dicitrate(out) <=> ADP + H(+) + iron(III) dicitrate(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56570", "l": "globoside IV3GalNAc-Gb4Cer + H(+) + UDP => globoside Gb4Cer + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5631885", "l": "PRDX1 overoxidizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44619", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + H2O <=> 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53584", "l": "NAD(+) + resolvin D2 = 7-oxoresolvin D2 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28973", "l": "H(+)(out) + shikimate(out) => H(+)(in) + shikimate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322135", "l": "Defective MMAA does not protect MUT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55757", "l": "2-oxoglutarate + an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + O2 => a 2-hydroxyornithine lipid + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28188", "l": "H2O2 + methylglyoxal + NH4(+) => aminoacetone + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19420", "l": "[phosphate](n) + dolichyl diphosphate <=> [phosphate](n+1) + dolichyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46359", "l": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52535", "l": "adenosine + GTP <=> AMP + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8856951", "l": "PP2A demethylation by PPME1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939066", "l": "PRKCB gene expression is stimulated by RUNX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13763", "l": "S-adenosyl-L-homocysteine + S-methyl-L-methionine => L-methionine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56609", "l": "5,10-methylenetetrahydrosulfopterin + glycine + H2O => L-serine + tetrahydrosulfopterin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55819", "l": "a bacteriochlorophyllide d + H2O + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide d + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797974", "l": "LRRTMs bind NRXNs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867047", "l": "PTPN3 dephosphorylates EPS15 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033709", "l": "D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity"}, {"i": "MetaCyc:RXN-7972"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420688", "l": "GABAB heterodimeric receptor binds GABA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29827", "l": "Mg(2+)(in) = Mg(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034845", "l": "naphthyl-2-methyl-succinyl-CoA dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9663511", "l": "BIL binds GSTA1, FABP1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103047", "l": "methyl beta-D-glucoside 6-phosphate glucohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008752", "l": "FMN reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948034", "l": "FGR binds LDL:LRP8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23443", "l": "4-chlorobenzoate + H2O <=> 4-hydroxybenzoate + chloride + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28291", "l": "(2E,6E)-farnesyl diphosphate + H2O => (5S,9S,10S)-drim-7-en-11-ol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660910", "l": "Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48066", "l": "ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate => ganglioside GD1b (d18:1(4E)) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16200", "l": "(3S)-3-hydroxybutanoyl-CoA + NADP(+) <=> acetoacetyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050579", "l": "vellosimine dehydrogenase activity"}, {"i": "KEGG.REACTION:R05827"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13319", "l": "(R)-glycerate + CO2 => (2R,3R)-tartrate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202111", "l": "AKT1 phosphorylates eNOS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55199", "l": "2-hydroxyoctadecanoyl-CoA <=> formyl-CoA + heptadecanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.118"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160874", "l": "HYAL1 hydrolyses (HA)50 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65892", "l": "4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate = H2O + xanthurenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696357", "l": "LAIR2 binds collagen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53794", "l": "benzothialdehyde + H2O2 => benzylthiol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52118", "l": "15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate => 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983144", "l": "Transport of Antigen peptide in to ER (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21379", "l": "3-(4-hydroxyphenyl)pyruvate + O2 <=> (S)-4-hydroxymandelate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20932", "l": "L-erythrulose 1-phosphate = dihydroxyacetone phosphate + formaldehyde"}, {"i": "EC:4.1.2.2", "l": "\"Ketotetrose-phosphate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3788061", "l": "Fibronectin degradation by ADAM8 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-877187", "l": "P2X7 mediates loss of intracellular K+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034799", "l": "dihydride TNP tautomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54667", "l": "(3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene <=> pre-alpha-onocerin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60649", "l": "an N-(acyl)-sphingosylphosphoethanolamine => an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956676", "l": "YAP1 binds TP73 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61546", "l": "ent-kaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46059", "l": "(11E)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (11E,13Z)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9627369", "l": "SEPT4 binds XIAP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46012", "l": "(S)-malate + a quinone = a quinol + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47856", "l": "ganglioside GD1a (d18:1(4E)) + H2O = ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213201", "l": "Formation of collagen fibres (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9679044", "l": "FKBP1A binds sirolimus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17592", "l": "2,2'-iminodipropanoate + H2O + NAD(+) <=> H(+) + L-alanine + NADH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58930", "l": "(6aR,11aR)-3,9-dihydroxypterocarpan + H2O => (3R,4R)-7,2',4'-trihydroxyisoflavanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46421", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664850", "l": "ATM binds PEX5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23548", "l": "guanosine(966) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.171", "l": "\"16S rRNA (guanine(966)-N(2))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449818", "l": "IL13 binds IL13RA2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36141", "l": "(2E)-hexadecenoyl-CoA + AMP + diphosphate => (E)-hexadec-2-enoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20649", "l": "23,24-dihydrocucurbitacin B + NADP(+) = cucurbitacin B + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132233", "l": "Proteolytic cleavage of complement factor C4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73945", "l": "FAS-mediated dimerization of procaspase-8 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114558", "l": "Thrombin-activated PARs activate Gq (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18683", "l": "phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine => phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004468", "l": "lysine N-acetyltransferase activity, acting on acetyl phosphate as donor"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050557", "l": "deacetylipecoside synthase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0050498", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated"}, {"i": "EC:1.14.20.-", "l": "\"With 2-oxoglutarate as one donor, and the other dehydrogenated\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28510", "l": "arbutin 6-phosphate + H2O = beta-D-glucose 6-phosphate + hydroquinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683687", "l": "Nucleoprotein is SUMOylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021596", "l": "Membrane estrogen receptors bind SRC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839078", "l": "Cytosolic FGFR1 fusion proteins bind PIK3R1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37457", "l": "1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050121", "l": "N-acylglucosamine 2-epimerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15113", "l": "5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5,6beta-triol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174963", "l": "NAT1 acetylation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3791295", "l": "Aggrecan degradation by MMP1,2,3,7,9,12,13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28734", "l": "H(+)(out) + L-leucine(in) <=> H(+)(in) + L-leucine(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047738", "l": "cellobiose phosphorylase activity"}, {"i": "RHEA:19493", "l": "D-cellobiose + phosphate = alpha-D-glucose 1-phosphate + D-glucose"}, {"i": "EC:2.4.1.20", "l": "\"Cellobiose phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14496", "l": "H2O + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] <=> ADP-D-ribose + L-arginyl-[dinitrogen reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005134", "l": "interleukin-2 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209924", "l": "Dopa is decarboxylated to dopamine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2167942", "l": "Collagen type XIII ectodomain shedding (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54302", "l": "n adenosine 3',5'-bisphosphate + chondroitin 4',6'-disulfate + n H(+) => n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004982", "l": "N-formyl peptide receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29236", "l": "a menaquinone + H(+) + NADH => a menaquinol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57396", "l": "(S)-S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine = 3-O-acetylpapaveroxine + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.352", "l": "\"3-O-acetyl-4'-O-demethylpapaveroxine 4'-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416690", "l": "SEMA4A binds to PLXND1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29215", "l": "fumarate + menaquinol-8 = menaquinone-8 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29780", "l": "ATP + H2O + L-methionine(out) => ADP + H(+) + L-methionine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "67.889182750938758", "identifiers": [{"i": "GO:0008173", "l": "RNA methyltransferase activity"}, {"i": "REACT:R-HSA-191784", "l": "snRNA Cap hypermethylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46444", "l": "(11Z)-hexadecenoyl-CoA + AH2 + O2 = (10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O"}, {"i": "EC:1.14.19.15", "l": "\"(11Z)-hexadec-11-enoyl-CoA conjugase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047257", "l": "diglucosyl diacylglycerol synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211924", "l": "CYP4B1 12-hydroxylates ARA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814764", "l": "Plasma membrane resorption (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17667", "l": "H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein] => L-lysyl-[protein] + octanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008847", "l": "Enterobacter ribonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008928", "l": "mannose-1-phosphate guanylyltransferase (GDP) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198440", "l": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372819", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166792", "l": "Conversion of C2 into C2a and C2b (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684350", "l": "pp1a forms a dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.1", "l": "\"Cystathionine gamma-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21343", "l": "1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 <=> 2 vanillin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990929", "l": "sulfoquinovosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2509827", "l": "ITPA hydrolyses ITP to IMP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202307", "l": "Change of PKC theta conformation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45053", "l": "(2E)-butenoyl-CoA + (R)-carnitine => CoA + O-(2E)-butenoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3149492", "l": "cob(II)alamin dissociates from MMACHC:MMADHC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.7", "l": "\"Chaperonin ATPase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102302", "l": "mycinamicin VI 2''-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-12801"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12116", "l": "A + H2 = AH2"}, {"i": "EC:1.12.99.6", "l": "\"Hydrogenase (acceptor)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64176", "l": "H2O + N-(9Z-octadecenoyl)-L-tryptophan = (9Z)-octadecenoate + L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48627", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + O2 <=> (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43641", "l": "dodecanoyl-CoA + H(+) + malonyl-[ACP] => 3-oxotetradecanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683769", "l": "O-glycosylation of 3a is terminated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65430", "l": "deamido-NAD(+)(out) + NAD(+)(in) => deamido-NAD(+)(in) + NAD(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156910", "l": "Formation of eEF1B complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112435", "l": "Formation of Elongin BC complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30760", "l": "5-methylcytosine + H(+) + H2O => NH4(+) + thymine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8954056", "l": "E2F6 binds TFDP2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852552", "l": "MST1R autophosphorylates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429449", "l": "Syk activation leads to SLP-76 activation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008745", "l": "N-acetylmuramoyl-L-alanine amidase activity"}, {"i": "EC:3.5.1.28", "l": "\"N-acetylmuramoyl-L-alanine amidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16590", "l": "A + sucrose => 3-dehydro-alpha-D-glucosyl beta-D-fructofuranoside + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46019", "l": "(20R)-20-hydroxypregn-4-en-3-one + NAD(+) <=> H(+) + NADH + progesterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54662", "l": "an aromatic aldehyde + hydrogen cyanide => an aromatic (S)-hydroxynitrile"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088264", "l": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3341294", "l": "Superoxide reduces cytochrome c (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938853", "l": "CDK6 binds RUNX1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029471", "l": "Hydrolysis of PC to PA by PLD (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103005", "l": "9,10-epoxystearate hydrolase activity"}, {"i": "MetaCyc:RXN-9806"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45718", "l": "CoA + glycine betaine + H(+) => H2O + N,N,N-trimethylglycyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56795", "l": "2 cob(II)alamin--[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] <=> 2 [corrinoid adenosyltransferase]-cob(I)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24868", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + 2-oxoglutarate + O2 <=> 4-O-deacetyl-16-O-demethylvindoline + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25906", "l": "dehypoxanthine futalosine + hypoxanthine => futalosine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31078", "l": "(3S)-3-hydroxydodecanoyl-CoA <=> (2E)-dodecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22910", "l": "3',5'-cyclic IMP + NH4(+) => 3',5'-cyclic AMP + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497878", "l": "Superoxide reacts rapidly with NO to form peroxynitrite (ONOO-) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58090", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoate + glycerol + H(+) => 1-(7Z,10Z,13Z,16Z-docosatetraenoyl)-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57247", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP <=> dGTP + H(+) + lactate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033446", "l": "AGC codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56838", "l": "5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine => [PQQ precursor protein] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687638", "l": "MLKL binds IP4, IP5 and IP6  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46892", "l": "2-oxoglutarate + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate = 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + L-glutamate"}, {"i": "EC:2.6.1.109", "l": "\"8-amino-3,8-dideoxy-alpha-D-manno-octulosonate transaminase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016934", "l": "extracellularly glycine-gated chloride channel activity"}, {"i": "REACT:R-HSA-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46674", "l": "5beta-dihydroaldosterone + NADP(+) => aldosterone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27944", "l": "NH4(+) + oxaloacetate => (3R)-3-hydroxy-D-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57057", "l": "D-apiofuranose + NAD(+) => D-apionolactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149440", "l": "Transport of VPU to Golgi apparatus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015474", "l": "autotransporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61843", "l": "brassicasterol + UDP-alpha-D-glucose <=> brassicasterol 3-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62479", "l": "3,4-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] <=> 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40277", "l": "(2E)-hexadecenedioyl-CoA + H2O2 => hexadecanedioyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004145", "l": "diamine N-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211651", "l": "Cleavage of PAK-2 at 212 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706319", "l": "Active FLT3 binds to SLA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59668", "l": "D-cellohexaose + O2 = D-cellohexaono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56349", "l": "4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 => 2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51772", "l": "dimethylallyl diphosphate + phlorisobutanophenone = 4-prenylphlorisobutanophenone + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52046", "l": "H(+) + mogroside IE + UDP => mogrol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035663", "l": "Toll-like receptor 2 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213246", "l": "Disassociation of CLIP from MHC II (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912368", "l": "MIR302A microRNA binds 3'UTR of NOTCH4 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31171", "l": "(3S)-hydroxytetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604712", "l": "Initial activation of proMMP7 by trypsin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39571", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30899", "l": "bis(beta-D-glucosyl) crocetin + UDP-alpha-D-glucose = beta-D-gentiobiosyl beta-D-glucosyl crocetin + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29199", "l": "(S)-dihydroorotate + menaquinone-8 = menaquinol-8 + orotate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13390", "l": "glutaryl-CoA + 2 H(+) + oxidized [electron-transfer flavoprotein] => (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15125", "l": "acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n) = CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n)"}, {"i": "EC:2.3.1.78", "l": "\"Heparan-alpha-glucosaminide N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418850", "l": "Activation of Cdc42 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18531", "l": "3-methylbutanal + H(+) + NADH => 3-methylbutanol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65692", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine = a diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961699", "l": "FBXO5 gene expression is stimulated by E2F1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381612", "l": "GLP1R binds GLP1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31436", "l": "(2E,6E)-farnesyl diphosphate => (+)-alpha-santalene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34998", "l": "L-rhamnose(in) <=> L-rhamnose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55527", "l": "H(+) + H2O + L-dopa + O2 <=> 3,4-dihydroxyphenylacetaldehyde + CO2 + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40383", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24786", "l": "3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2 => 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38172", "l": "hexadecane-1,2-diol + hexadecanoyl-CoA => 2-hydroxyhexadecyl hexadecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37614", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785762", "l": "IL13RA1 binds TYK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25675", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63111", "l": "16-hydroxy-ilicicolin A epoxide <=> ascofuranol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17878", "l": "a catechol + S-adenosyl-L-methionine => a guaiacol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003854", "l": "3-beta-hydroxy-delta5-steroid dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426676", "l": "Formation of laminin networks (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21846", "l": "CoA + H(+) + N(2)-phenylacetyl-L-glutamine => L-glutamine + phenylacetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30386", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-7-epi-alpha-selinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5689111", "l": "PARK2 autoubiquitinates (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59445", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene + A => 1,1'-dihydroxy-3,4-didehydro-1,2-dihydrolycopene + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034057", "l": "RNA strand-exchange activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36537", "l": "CoA + H(+) + N-docosanoylsphinganine => docosanoyl-CoA + sphinganine"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0034069", "l": "aminoglycoside N-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62573", "l": "H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteinylglycine => glycine + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33424", "l": "N(pros)-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out) => diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.11", "l": "\"Glutamate carboxypeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174235", "l": "Association of Emi1 with Cdc20 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375395", "l": "C5a receptor binds C5a anaphylatoxin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37610", "l": "(6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444523", "l": "CXCR5 binds CXCL13 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0051499", "l": "D-aminoacyl-tRNA deacylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11015", "l": "H2O + L-tryptophanamide <=> L-tryptophan + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1467269", "l": "Beta-defensins bind microbial membranes causing disruption (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694563", "l": "ABHD10 hydrolyses MPAG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2317332", "l": "PIP3 recruits AKT to the membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797554", "l": "ABP1 binds SHANK proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48169", "l": "H2O + N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine => N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851890", "l": "MET phosphorylates SHC1-2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60483", "l": "2 UTP <=> c-di-UMP + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035529", "l": "NADH pyrophosphatase activity"}, {"i": "MetaCyc:RXN0-4401"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33667", "l": "H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine + NADPH + O2 = H2O + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047742", "l": "chenodeoxycholoyltaurine hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56089", "l": "CMP-N-acetyl-beta-neuraminate + globoside MSGG => CMP + globoside DSGG + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351936", "l": "Caspase-mediated cleavage of claspin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0101021", "l": "estrogen 2-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211164", "l": "AKT phosphorylates FOXO1A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41089", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22892", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH"}, {"i": "EC:1.5.1.15", "l": "\"Methylenetetrahydrofolate dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799431", "l": "TP53 binds HIPK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1470009", "l": "Phosphorylation of STATs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58911", "l": "7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH <=> C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710101", "l": "CASP4, CASP5 cleave GSDMD (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856930", "l": "EPAS1 (HIF2A) and activated NR3C1 (GCR) bind PTK6 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11941", "l": "2 H(+) + H2O + L-citrulline => CO2 + L-ornithine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849900", "l": "SALMs1-3 bind each other in cis interactions (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009541", "l": "ESR1 binds to TFF1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2160874", "l": "HYAL1 hydrolyses (HA)50 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47791", "l": "a cytidine in 28S rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.23", "l": "\"dUTP diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50622", "l": "alpha-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45175", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33114", "l": "(2E,6E)-farnesyl diphosphate <=> beta-copaene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865276", "l": "PDGF-AB clevage by Furin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25200", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O <=> 5-amino-6-(D-ribitylamino)uracil + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65853", "l": "a 3-oxo-Delta(1)-steroid + H2O => a 1-hydroxy-3-oxo steroid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12700", "l": "ATP + dGMP <=> ADP + dGDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19999", "l": "phosphate + pyruvate => H2O + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004746", "l": "riboflavin synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46262", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O => 2 [Fe(II)-cytochrome b5] + an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33765", "l": "a 2,3-saturated acyl-CoA + NADP(+) => a (2E)-enoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59769", "l": "hexadecanoyl-CoA + L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] => CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25492", "l": "(2E)-geranyl diphosphate = (-)-beta-phellandrene + diphosphate"}, {"i": "EC:4.2.3.52", "l": "\"(4S)-beta-phellandrene synthase (geranyl-diphosphate-cyclizing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17890", "l": "H2O + phosphoethanolamine => acetaldehyde + NH4(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730899", "l": "Oligomerization of BCL10 and MALT1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177930", "l": "GAB1 phosphorylation by EGFR kinase (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693575", "l": "DNA-PKcs autophosphorylates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879562", "l": "SLCO2B1 has a narrow substrate specificity (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12462", "l": "fumarate + H2O => (S)-malate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362549", "l": "Hh-Np traffics to the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5681980", "l": "ATG12 binds ATG7 dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15830", "l": "a 16alpha-hydroxysteroid => a 16beta-hydroxysteroid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.141"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019779", "l": "Atg8 activating enzyme activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52913", "l": "3-dimethylallyl-4-hydroxymandelate + O2 => 3-dimethylallyl-4-hydroxybenzoate + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341073", "l": "PIAS3 SUMOylates PGR with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40224", "l": "4,8-dimethylnonanoyl-CoA + H2O => 4,8-dimethylnonanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17943", "l": "2-methyl-cis-aconitate + H2O => (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40430", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016508", "l": "long-chain-enoyl-CoA hydratase activity"}, {"i": "MetaCyc:LONG-CHAIN-ENOYL-COA-HYDRATASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38438", "l": "(9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730872", "l": "Activation of Calcineurin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40397", "l": "H2O2 + NAD(+) => 1,2-dihydro-beta-NAD + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14847", "l": "(S)-2,3-dihydrodipicolinate + H(+) + 2 H2O => L-aspartate 4-semialdehyde + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2197770", "l": "STAB1 (FEEL-1) binds ligands (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69053", "l": "RFC binding displaces Pol Alpha (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140696", "l": "(S)-2-hydroxyglutarate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001181", "l": "RNA polymerase I general transcription initiation factor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20053", "l": "NAD(+) + ribitol = D-ribulose + H(+) + NADH"}, {"i": "EC:1.1.1.56", "l": "\"Ribitol 2-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48244", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 = CMP + ganglioside GM1b + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12036", "l": "(S)-3-(imidazol-5-yl)lactate + NAD(+) = 3-(imidazol-5-yl)pyruvate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15547", "l": "acetate + pyruvate => (3S)-citramalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54728", "l": "acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]"}, {"i": "EC:2.1.3.15", "l": "\"Acetyl-CoA carboxytransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54837", "l": "H(+) + heptan-2-one + NADPH + O2 => H2O + NADP(+) + pentyl acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54787", "l": "Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide <=> Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33598", "l": "(4R)-hydroxysphinganine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58204", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine = dihydroalstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636658", "l": "esxA binds PGK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797553", "l": "Protein 4.1 binds CASK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666001", "l": "Profilin:G-actin binds MKL1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981814", "l": "GalNAc alpha-2,6-sialyltransferase II can add a sialic acid to the T antigen at the alpha 6 position (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21945", "l": "ATP + D-cellobiose => 6-phospho-beta-D-glucosyl-(1->4)-D-glucose + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46718", "l": "H(+) + N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine => pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46164", "l": "a quinone + H(+) + NADPH = a quinol + NADP(+)"}, {"i": "EC:1.6.5.10", "l": "\"NADPH dehydrogenase (quinone)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013108", "l": "GDIs block activation of RHOC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8858346", "l": "AMHR2 binds AMH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46270", "l": "2 [Fe(III)-cytochrome b5] + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O => 2 [Fe(II)-cytochrome b5] + an N-acyl-(4R)-4-hydroxysphinganine + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46523", "l": "2 [Fe(II)-cytochrome b5] + an N-(1,2 saturated acyl)-(4R)-hydroxysphinganine + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + an N-(2R-hydroxyacyl)-4R-hydroxysphinganine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58512", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.4.1", "l": "\"Protein disulfide-isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3814820", "l": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23259", "l": "adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine <=> adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63317", "l": "(9Z,12Z)-octadecadienoate + O2 => 9-hydroperoxy-(10E,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66736", "l": "ATP + beta-citrylglutamate(in) + H2O = ADP + beta-citrylglutamate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901982", "l": "maltose binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114553", "l": "Activation of conventional Protein Kinase C (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0071916", "l": "dipeptide transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10550", "l": "4-guanidinobutanamide + CO2 + H2O => L-arginine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41846", "l": "(2E)-octenoyl-[ACP] + H2O => (3R)-hydroxyoctanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15539", "l": "3-sulfopyruvate + H(+) + NADPH => (R)-3-sulfolactate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39686", "l": "3-oxo-(11Z)-octadecenoyl-CoA + H(+) + NADPH <=> (R)-3-hydroxy-(11Z)-octadecenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2219524", "l": "PDPK1 binds PIP2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674546", "l": "CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62814", "l": "2 dinapinone A + 2 H2O => 4 monapinone A + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48950", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin] => 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51732", "l": "glandicoline B + S-adenosyl-L-methionine = H(+) + meleagrin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254251", "l": "ERBB4s80 binds YAP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31492", "l": "soyasaponin III + UDP-beta-L-rhamnose => H(+) + soyasaponin I + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18536", "l": "5-hydroxy-L-tryptophan + H(+) <=> CO2 + serotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74711", "l": "Phosphorylation of IRS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-481007", "l": "Exocytosis of platelet alpha granule contents (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37599", "l": "(9Z,12Z)-hexadecadienoyl-CoA + AH2 + O2 = (9Z,12Z,15Z)-hexadecatrienoyl-CoA + A + 2 H2O"}, {"i": "EC:1.14.19.13", "l": "\"Acyl-CoA 15-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66463", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O <=> 14betaH-scalarane-17alpha-19-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62797", "l": "H(+) + NADPH + O2 + 2 rubrofusarin B => aurasperone A + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58318", "l": "cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine => beta-D-glucosyl-N-hexadecanoylsphing-4E-enine + cholesterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-445714", "l": "Aquaporin-3 passively transports water out of cell (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428917", "l": "G13 activation by TP receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43656", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CTP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26142", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + NH4(+) => 2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990883", "l": "rRNA cytidine N-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28917", "l": "4-aminobutanoate(out) + H(+)(out) => 4-aminobutanoate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24827", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33386", "l": "(S)-malate + UDP-N-acetyl-alpha-D-glucosamine <=> (S)-malyl N-acetyl-alpha-D-glucosaminide + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11078", "l": "catechol + CO2 + NAD(+) + NH4(+) => anthranilate + 3 H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31705", "l": "H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-ol => 2 H(+) + O2 + pentalenene + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28345", "l": "dITP + H2O <=> dIMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30482", "l": "L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45276", "l": "12-phosphooxy-(9E)-octadecenoate + H2O = 12-hydroxy-(9E)-octadecenoate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66853", "l": "(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25507", "l": "(2E)-geranyl diphosphate <=> beta-phellandrene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654163", "l": "Activated FGFR4 binds PLCG1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1067659", "l": "Assembly of hexameric IL-6 receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35976", "l": "2-oxoglutarate + AH2 + fumitremorgin B + 2 O2 => A + CO2 + H2O + succinate + verruculogen"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65342", "l": "CoA + O-acetyl-L-threonyl-[protein] => acetyl-CoA + L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693111", "l": "RHOF auto-activates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24805", "l": "(2S)-2-acetolactate + thiamine diphosphate = 2-(1-hydroxyethyl)thiamine diphosphate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23873", "l": "(R)-propane-1,2-diol + NAD(+) => (R)-lactaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814094", "l": "ARL1:GTP binds ARFIP2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698041", "l": "p-STAT5 binds the CDKN1A gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626945", "l": "CREBBP acetylates FOXO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26143", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + H2O <=> 5-amino-6-(5-phospho-D-ribitylamino)uracil + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18714", "l": "2-oxoglutarate + UDP-N-acetylbacillosamine => L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-D-gluco-hex-4-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981648", "l": "C4b binding protein binds C4bC2a (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247836", "l": "Retromer recycles WLS to the Golgi (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420052", "l": "Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202233", "l": "Inactivation of Lck by Csk (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38397", "l": "(9Z)-hexadecenoate + 1,3-di-(9Z)-hexadecenoylglycerol + H(+) => 1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451366", "l": "Activation of p38MAPK by DSCAM (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61033", "l": "3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-methionine => 5-hydroxy-3,7,3',4'-tetramethoxyflavone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21157", "l": "(2R)-2-phosphoglycerate + H2O => (R)-glycerate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21348", "l": "8 H(+) + 10 malonyl-CoA = 10 CO2 + 10 CoA + 2 H2O + tetracenomycin F2"}, {"i": "EC:2.3.1.235", "l": "\"Tetracenomycin F2 synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42068", "l": "(3R,5R)-clavulanate-9-aldehyde + H(+) + NADPH = clavulanate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61271", "l": "H2O + L-2-aminohexanoate + O2 <=> 2-oxohexanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1169402", "l": "ISGylation of E2 conjugating enzymes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11733", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoraflavanone B => H(+) + H2O + leachianone G + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20599", "l": "H(+) + L-cystine + NADH => 2 L-cysteine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009046", "l": "zinc D-Ala-D-Ala carboxypeptidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004780", "l": "sulfate adenylyltransferase (ADP) activity"}, {"i": "KEGG.REACTION:R00530"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102436", "l": "7-methylmyricetin 4'-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-13911"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621918", "l": "Defective GCK does not phosphorylate Glc to form G6P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43789", "l": "acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O => ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4093342", "l": "SDC2 multimerises (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21391", "l": "H2O + L-2-aminohexano-6-lactam <=> L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.-", "l": "\"Acid--thiol ligases\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033963", "l": "cholesterol-5,6-oxide hydrolase activity"}, {"i": "MetaCyc:RXN-8650"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11401", "l": "GDP-6-deoxy-alpha-D-altrose + sordaricin => 4'-O-demethylsordarin + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34401", "l": "9-cis-10'-apo-beta-carotenal + beta-ionone => 9-cis-beta-carotene + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60733", "l": "H2O + NADP(+) + perillyl aldehyde => 2 H(+) + NADPH + perillate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2186780", "l": "Degradation of Ub-SMAD7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45967", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 H2O <=> 2 AMP + ATP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901515", "l": "poly-beta-1,6-N-acetyl-D-glucosamine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41524", "l": "5 H(+) + 5 malonyl-CoA = 5 CO2 + 5 CoA + H2O + naphthalene-1,3,6,8-tetrol"}, {"i": "EC:2.3.1.233", "l": "\"1,3,6,8-tetrahydroxynaphthalene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193655", "l": "Myelin components can interact with p75NTR:NgR:LINGO1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39701", "l": "(2E,13Z)-eicosadienoyl-CoA + H2O => (R)-3-hydroxy-(13Z)-eicosenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27780", "l": "2-all-trans-octaprenylphenol + CO2 => 4-hydroxy-3-all-trans-octaprenylbenzoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114264", "l": "Translocation of activated BAX to the mitochondria (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.14"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183055", "l": "Binding of CBL to EGFR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48754", "l": "CO2 + H(+) + succinate + validamycin B => 2-oxoglutarate + O2 + validamycin A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694377", "l": "pp1a cleaves itself (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174706", "l": "chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168848", "l": "tBID binds to inactive BAK protein (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36419", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050518", "l": "2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696670", "l": "CHD1L is recruited to GG-NER site (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57284", "l": "a guanosine in RNA + methylglyoxal = an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38034", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) <=> (2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140491", "l": "ubiquitin-like hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36999", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39730", "l": "a sphingomyelin(in) <=> a sphingomyelin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34474", "l": "NAD(+) + propanoyl-CoA <=> acryloyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20527", "l": "ADP + H(+) + N(5)-ethyl-L-glutamine + phosphate => ATP + ethylamine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36807", "l": "H(+) + malonyl-CoA + octacosanoyl-CoA = 3-oxo-triacontanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16232", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) <=> a CDP-1,2-diacyl-sn-glycerol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56481", "l": "(4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 => (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12756", "l": "glycerol + NADP(+) <=> dihydroxyacetone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004110", "l": "corticosteroid side-chain-isomerase activity"}, {"i": "MetaCyc:CORTICOSTEROID-SIDE-CHAIN-ISOMERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956684", "l": "ITCH polyubiquitinates TP73 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19780", "l": "A + L-pipecolate <=> AH2 + H(+) + L-1-piperideine-6-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49543", "l": "(2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate <=> (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944257", "l": "Association of procollagen type XXIV (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10742", "l": "a ketone + H(+) + NADH => a secondary alcohol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140069", "l": "histone butyryltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37084", "l": "[sulfur carrier]-SH + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + S-adenosyl-L-methionine => [sulfur carrier]-H + H(+) + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52356", "l": "3'-phosphoadenylyl sulfate + pregnenolone = adenosine 3',5'-bisphosphate + H(+) + pregnenolone sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44264", "l": "eicosanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-nonadecylpyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9669893", "l": "KIT binds type I TKIs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49113", "l": "phenazine-1-carboxylate + S-adenosyl-L-methionine => 5-methyl-phenazine-1-carboxylate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801101", "l": "RABGGTA binds RABGGTB (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4086410", "l": "CDK1 phosphorylates BORA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28243", "l": "O2 + pratensein + reduced [NADPH--hemoprotein reductase] => 5-hydroxypseudobaptigenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51115", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858270", "l": "HILPDA binds lipid droplets (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20144", "l": "an S-alkyl-L-cysteine S-oxide <=> 2-aminoprop-2-enoate + an S-alkyl sulfenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61926", "l": "(2S,4R)-ketoconazole(out) + ADP + H(+) + phosphate => (2S,4R)-ketoconazole(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110319", "l": "Elongation by POLH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0016669", "l": "oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor"}, {"i": "EC:1.8.2.-", "l": "\"With a cytochrome as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37126", "l": "sphing-4-enine + tetracosenoyl-CoA <=> CoA + H(+) + N-(tetracosenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380949", "l": "AMPK is dephosphorylated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964619", "l": "PAK1 binds ARHGEF6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975594", "l": "PLB1 hydrolyses RPALM to atROL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875558", "l": "RAPGEF1 binds CRK,CRKL (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13642", "l": "H(+) + methane + NADPH + O2 => H2O + methanol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1470010", "l": "Dimerization of STATs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102913", "l": "3-aminomethylindole N-methyltransferase activity"}, {"i": "RHEA:52268", "l": "3-(aminomethyl)indole + S-adenosyl-L-methionine = (1H-indol-3-yl)-N-methylmethanamine + H(+) + S-adenosyl-L-homocysteine"}, {"i": "MetaCyc:RXN-8686"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55964", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43187", "l": "S-adenosyl-L-methionine + uridine(2843) in 25S rRNA <=> H(+) + N(3)-methyluridine(2843) in 25S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174959", "l": "The acetyl group from acetyl-CoA is transferred to the NAT1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951486", "l": "CD46 binds C4b (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432712", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65109", "l": "aculene C + L-prolyl-[peptidyl-carrier protein] => aculene A + holo-[peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31778", "l": "all-trans-retinyl hexadecanoate + H2O <=> 11-cis-retinol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51668", "l": "2 H(+) + mevastatin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pravastatin lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1471354", "l": "HNP1-3 bind gp120 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801776", "l": "REG3A binds bacterial phospholipids (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47911", "l": "6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O <=> 6-deoxy-6-sulfo-D-gluconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193981", "l": "CYP21A2 oxidises 17HPROG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23048", "l": "(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate"}, {"i": "RHEA:24734", "l": "2-oxoglutarate + 4-hydroxybutanoate = (R)-2-hydroxyglutarate + succinate semialdehyde"}, {"i": "EC:1.1.99.24", "l": "\"Hydroxyacid-oxoacid transhydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169210", "l": "PTP1B dephosphorylates JAK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050378", "l": "UDP-glucuronate 4-epimerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40556", "l": "dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2 => dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24461", "l": "H(+) + malonyl-[ACP] => acetyl-[ACP] + CO2"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004793", "l": "threonine aldolase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102714", "l": "gibberellin A12,oxoglutarate:oxygen oxidoreductase activity"}, {"i": "MetaCyc:RXN-6544"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404134", "l": "RBP4:atROL binds TTR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102001", "l": "isoleucine N-monooxygenase (oxime forming) activity"}, {"i": "RHEA:28602", "l": "L-isoleucine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (1E,2S)-2-methylbutanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.39", "l": "\"Isoleucine N-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029473", "l": "Branching and elongation of mother and daughter filaments (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60668", "l": "(R,R)-chrysanthemol + NAD(+) = (1R,3R)-chrysanthemal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37404", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53585", "l": "NAD(+) + resolvin D2 => 7-oxoresolvin D2 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29524", "l": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210805", "l": "Removal of miRNA passenger strand (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38420", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O => 1,3-di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928639", "l": "p-EFNB binds GRB4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69116", "l": "Formation of Okazaki fragments (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33098", "l": "chorismate + inosine + phosphoenolpyruvate <=> futalosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43011", "l": "D-serine <=> 2-aminoprop-2-enoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41974", "l": "CMP + ganglioside GT1aalpha (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E))"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30424", "l": "(2E,6E)-farnesyl diphosphate => (+)-delta-selinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52295", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31466", "l": "crocetin + UDP-alpha-D-glucose <=> beta-D-glucosyl crocetin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34948", "l": "(Z)-3-aminoacrylate + H(+) + H2O => 3-oxopropanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018794", "l": "RHOV binds effectors at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64205", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(10Z-heptadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174202", "l": "Degradation of multiubiquitinated Securin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-417820", "l": "P2Y9 receptor can bind to LPA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32283", "l": "3-hydroxyanthranilate + O2 = H(+) + H2O + quinolinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47234", "l": "(2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44566", "l": "4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-decaprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070009", "l": "serine-type aminopeptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50656", "l": "3-(2-methylsulfanyl)ethylmalate = 2-(2-methylsulfanyl)ethylmaleate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004777", "l": "succinate-semialdehyde dehydrogenase (NAD+) activity"}, {"i": "REACT:R-HSA-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392206", "l": "G alpha (i) inhibits adenylate cyclase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866851", "l": "CFTR transits to the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2990882", "l": "CDK1 phosphorylates NUP98 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033935", "l": "oligoxyloglucan beta-glycosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612593", "l": "ERBB4 binds DLG4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53740", "l": "[Rab1 protein]-O(4)-(5'-adenylyl)-L-tyrosine + H2O = [Rab1 protein]-L-tyrosine + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018774", "l": "RHOBTB1 binds GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23196", "l": "3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine = 3 AMP + 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine"}, {"i": "EC:6.3.2.26", "l": "\"N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57327", "l": "acetyl-CoA + N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein] <=> CoA + H(+) + N-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6810076", "l": "DDO oxidizes D-Asp to OA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69074", "l": "Formation of Processive Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008911", "l": "lactaldehyde dehydrogenase activity"}, {"i": "MetaCyc:LACTALDDEHYDROG-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34297", "l": "2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP => 2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11308", "l": "acetyl-CoA + ATP + hydrogencarbonate = ADP + H(+) + malonyl-CoA + phosphate"}, {"i": "EC:6.4.1.2", "l": "\"Acetyl-CoA carboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8934465", "l": "SHC1 binds PTPN12 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12908", "l": "alpha-D-mannose 1-phosphate + GDP + H(+) <=> GDP-alpha-D-mannose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58453", "l": "N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60884", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine-phospho-ribonucleoside in mRNA + H2O = (N(7)-methyl 5'-triphospho-guanosine)-adenosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102054", "l": "maleylpyruvate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45111", "l": "(+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase] <=> 13-hydroxy-alpha-tocopherol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2029473", "l": "Branching and elongation of mother and daughter filaments (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043874", "l": "acireductone synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17978", "l": "a long-chain primary fatty alcohol + H2O + 2 NAD(+) => a long-chain fatty acid + 3 H(+) + 2 NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004460", "l": "L-lactate dehydrogenase (cytochrome) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38342", "l": "(20S)-ginsenoside Rb1 + H2O <=> (20S)-ginsenoside Rd + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76416", "l": "Benzene is hydroxylated to phenol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54708", "l": "N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60046", "l": "alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + H(+) + UDP => beta-D-Gal-(1<->1')-Cer + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28570", "l": "ATP + L-serine = diphosphate + L-seryl-5'-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9671145", "l": "DKC1 binds SHQ1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52796", "l": "2 H(+) + Ni-sirohydrochlorin = Ni(2+) + sirohydrochlorin"}, {"i": "EC:4.99.1.11", "l": "\"Sirohydrochlorin nickelchelatase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008763", "l": "UDP-N-acetylmuramate-L-alanine ligase activity"}, {"i": "RHEA:23372", "l": "ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine"}, {"i": "EC:6.3.2.8", "l": "\"UDP-N-acetylmuramate--L-alanine ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40814", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10667", "l": "NAD(+) + perillyl alcohol <=> H(+) + NADH + perillyl aldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15219", "l": "CoA + ecdysone hexadecanoate => ecdysone + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54083", "l": "5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine <=> 5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25876", "l": "L-aspartate + O2 = H2O2 + iminosuccinate"}, {"i": "EC:1.4.3.16", "l": "\"L-aspartate oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31969", "l": "ent-11beta-hydroxycassa-12,15-diene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1013020", "l": "Activation of GIRK/Kir3 Channels (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549364", "l": "Expression of SERPINE1 (PAI-1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9727349", "l": "XDH dehydrogenates xanthine to form urate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047190", "l": "2-acylglycerophosphocholine O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.96", "l": "\"Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.167", "l": "\"Baicalin-beta-D-glucuronidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13838", "l": "cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) => 4,5-dihydroxyphthalate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797553", "l": "Protein 4.1 binds CASK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27354", "l": "4'-demethylrebeccamycin + S-adenosyl-L-methionine => H(+) + rebeccamycin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8863727", "l": "STON2 is neddylated (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43235", "l": "H2O + isatin <=> H(+) + isatinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10324", "l": "an L-glycol + NADP(+) = a 2-hydroxycarbonyl + H(+) + NADPH"}, {"i": "RHEA:10328", "l": "an L-glycol + NAD(+) = a 2-hydroxycarbonyl + H(+) + NADH"}, {"i": "EC:1.1.1.185", "l": "\"L-glycol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6802973", "l": "PLK3 phosphorylates CDC25C (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22622", "l": "3-indoleglycolaldehyde + CO2 + NH4(+) => H(+) + L-tryptophan + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050502", "l": "cis-zeatin O-beta-D-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265010", "l": "Cystine-bonded Proinsulin translocates from the endoplasmic reticulum to the Golgi (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37485", "l": "1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-dodecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16039", "l": "2-deoxy-alpha-D-ribose 1-phosphate + thymine => phosphate + thymidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28136", "l": "(2S)-hesperetin + rutinose => (2S)-hesperidin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30871", "l": "2-deoxy-D-ribose + ATP = 2-deoxy-D-ribose 5-phosphate + ADP + H(+)"}, {"i": "EC:2.7.1.229", "l": "\"Deoxyribokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32871", "l": "a 2-acylglycerol + H2O = a carboxylate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810937", "l": "Lamellar bodies bind the early cornified envelope (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390598", "l": "Myosin Binds ATP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34917", "l": "D-galactose(out) => D-galactose(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043522", "l": "leucine zipper domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60277", "l": "L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177934", "l": "EGFR autophosphorylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0008937", "l": "ferredoxin-NAD(P) reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0046030", "l": "inositol trisphosphate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-350651", "l": "Caspase-mediated cleavage of MASK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654224", "l": "Activated FGFR3 binds PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209925", "l": "DIT and MIT combine to form triiodothyronine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158357", "l": "factor XIIa binds SERPING1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19498", "l": "H(+) + L-aspartate => beta-alanine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051982", "l": "copper-nicotianamine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026377", "l": "NTF4-bound NTRK2 dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8863727", "l": "STON2 is neddylated (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654399", "l": "Activated FGFR2 binds FRS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59853", "l": "(2S,3R)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH => (R)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391941", "l": "BLT receptors can bind LTB4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193668", "l": "p75NTR and RHOA-GDI interact (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9656891", "l": "OPN1SW binds 11cRAL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38107", "l": "2-dehydro-3-deoxy-L-galactonate = L-glyceraldehyde + pyruvate"}, {"i": "EC:4.1.2.54", "l": "\"L-threo-3-deoxy-hexylosonate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19238", "l": "4-carboxymethyl-4-methylbut-2-en-1,4-olide => 4-carboxymethyl-3-methylbut-2-en-1,4-olide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35306", "l": "3-hydroxyisopentadecanoyl-CoA + NADP(+) <=> 3-oxoisopentadecanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34417", "l": "(1R,4R)-5-oxo-1,2-campholide + FMN + H(+) + H2O => (1R,4R)-bornane-2,5-dione + FMNH2 + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032051", "l": "clathrin light chain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021935", "l": "SST gene expression is stimulated by MECP2 and CREB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950782", "l": "p-STAT1 binds p-STAT3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419644", "l": "Transphosphorylation of pLIMK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64902", "l": "H(+) + phosphate + UDP => H2O + UTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53478", "l": "(6Z,9Z,12Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21721", "l": "formamide => H2O + hydrogen cyanide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070379", "l": "high mobility group box 1 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.42"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13196", "l": "5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) <=> 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47859", "l": "ganglioside GD1a (d18:1(4E)) + H2O <=> ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61830", "l": "H(+) + stigmasteryl 3-beta-D-glucoside + UDP => stigmasterol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176116", "l": "Recruitment and activation of Chk1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27490", "l": "2 D-sedoheptulose 7-phosphate => D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18865", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2-methylpropanoyl-CoA = (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[protein] + CoA"}, {"i": "EC:2.3.1.168", "l": "\"Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63310", "l": "11-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706304", "l": "Active FLT3 binds to GRAP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5213464", "l": "RIPK1 is phosphorylated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449115", "l": "IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9615348", "l": "AGT(34-41) binds to AGTR2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14967", "l": "a carboxylate + H(+) + phosphate => an acyl phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38639", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10570", "l": "H(+) + luteolin 7-O-beta-D-glucuronide + UDP => luteolin + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400204", "l": "PPARA binds RXRA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.-.-", "l": "\"Acting on NADH or NADPH\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54557", "l": "5'-end ribonucleotide-tRNA(His) + ATP + H(+) => an adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29970", "l": "2'-deoxyuridine(in) + H(+)(in) <=> 2'-deoxyuridine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004109", "l": "coproporphyrinogen oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12163", "l": "2-deoxy-D-gluconate + NAD(+) <=> 3-dehydro-2-deoxy-D-gluconate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.28"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56911", "l": "(7S)-O-acetylsalutaridinol <=> acetate + H(+) + thebaine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-517705", "l": "p-S318,221-HuR binds mRNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65888", "l": "2-oxoglutarate + 3-hydroxy-L-kynurenine = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050017", "l": "L-3-cyanoalanine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.83", "l": "\"Monoterpene epsilon-lactone hydrolase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044654", "l": "starch alpha-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250264", "l": "TXNIP binds reduced thioredoxin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.202", "l": "\"Endo-chitodextinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28348", "l": "7,8-dihydromonapterin 3'-triphosphate => 7,8-dihydroneopterin 3'-triphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033738", "l": "methylenetetrahydrofolate reductase (ferredoxin) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.11", "l": "\"Guluronate-specific alginate lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676596", "l": "TRAF3 binds BAFFR:BAFF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17460", "l": "[sulfur-carrier protein]-L-cysteine + L-cysteine <=> [sulfur-carrier protein]-S-sulfanyl-L-cysteine + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64187", "l": "H2O + N-(9Z-octadecenoyl)-L-tyrosine <=> (9Z)-octadecenoate + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380316", "l": "Association of NuMA with microtubules (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2752115", "l": "SPP1 (osteopontin) binds CD44 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034813", "l": "benzo(a)pyrene 7,8-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44113", "l": "hexadecanoyl-CoA + nonan-1-ol => CoA + nonyl hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38646", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42804", "l": "5,6,7,8-tetrahydromethanopterin + A = 7,8-dihydromethanopterin + AH2"}, {"i": "EC:1.5.99.15", "l": "\"Dihydromethanopterin reductase (acceptor)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-217255", "l": "FMO1:FAD N-oxidises TAM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-561072", "l": "OCT3 mediates renal uptake of organic cations (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52377", "l": "(+)-sesamin monocatechol + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n => (+)-sesamin dicatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800798", "l": "The PIDDosome binds CASP2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008738", "l": "L-fuculose-phosphate aldolase activity"}, {"i": "MetaCyc:FUCPALDOL-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975156", "l": "IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60744", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-pyrethrolone = CoA + pyrethrin I"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61141", "l": "(2R,3R)-dihydromyricetin + 2-oxoglutarate + O2 => CO2 + H(+) + H2O + myricetin + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67011", "l": "a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9611277", "l": "P2RY12 binds P2RY12 antagonists (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362486", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787737", "l": "CSF3R binds CSF3 dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009541", "l": "ESR1 binds to TFF1 gene promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39131", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64610", "l": "diphosphate + uridylyl-L-threonyl-[protein] => L-threonyl-[protein] + UTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56468", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 bromide + 3 FADH2 + 3 O2 = (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 FAD + 6 H2O"}, {"i": "EC:1.14.19.57", "l": "\"1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] brominase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58233", "l": "L-seryl-[protein] + NAD(+) => H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55240", "l": "1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = (9Z)-octadecenoate + 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38249", "l": "1-O-hexadecyl (9Z)-hexadecenoate + CoA => (9Z)-hexadecenoyl-CoA + hexadecan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60208", "l": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate"}, {"i": "EC:1.14.11.67", "l": "\"[Histone H3]-trimethyl-L-lysine(4) demethylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41098", "l": "H2O + sphing-4-enine-phosphocholine <=> H(+) + phosphocholine + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210430", "l": "Release of L-Glutamate at the synapse (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990003", "l": "inosine-diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952371", "l": "MDM2 binds RUNX3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665304", "l": "ERBB2 T862A does not bind sapitinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863494", "l": "ASICs bind STOML3, (STOM) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608862", "l": "SCRIB is required for asymmetric membrane localization of VANGL2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606807", "l": "Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46268", "l": "2 [Fe(II)-cytochrome b5] + an N-acyl-(4R)-4-hydroxysphinganine + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034523", "l": "3-formylsalicylate oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2574845", "l": "AJUBA binds centrosome-associated AURKA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62521", "l": "a cytidine in rRNA + S-adenosyl-L-methionine => an N(4)-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65404", "l": "butan-1-ol + hexanoyl-CoA = butyl hexanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198314", "l": "DAG stimulates protein kinase C-delta (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112434", "l": "Formation of DSIF complex  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60365", "l": "H(+)(out) + myo-inositol(out) => H(+)(in) + myo-inositol(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64835", "l": "3-hydroxybenzyl alcohol + benzoyl-CoA <=> 3-hydroxy-benzyl benzoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13988", "l": "ATP + L-homoserine <=> ADP + H(+) + O-phospho-L-homoserine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0033612", "l": "receptor serine/threonine kinase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419389", "l": "LPA-binding receptors bind LPA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938930", "l": "RUNX1 binds ELF2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52180", "l": "(E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] = (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917730", "l": "Cargo Recognition And Sorting (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33183", "l": "citrate(in) = citrate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5228992", "l": "ROCK1,ROCK2 are activated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19651", "l": "AMP + diphosphate + L-aspartyl-tRNA(Asp) => ATP + L-aspartate + tRNA(Asp)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57116", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53930", "l": "a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine => a tertiary amine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42046", "l": "GDP + globoside Globo-H (d18:1(4E)) + H(+) => GDP-beta-L-fucose + globoside GalGb4Cer (d18:1(4E))"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56514", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate => 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-182990", "l": "Sprouty sequesters CBL away from active EGFR (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59643", "l": "D-xylotetraose + O2 <=> D-xylotetraono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70592", "l": "PXLP-K259-GOT1 dimer deaminates L-Asp (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.21", "l": "\"Squalene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25254", "l": "ATP + N-acetyl-D-mannosamine => ADP + H(+) + N-acetyl-D-mannosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56054", "l": "2 alpha-D-mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => 2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35130", "l": "L-alanyl-D-glutamate(out) <=> L-alanyl-D-glutamate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674531", "l": "AAMP binds EGFR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-561072", "l": "OCT3 mediates renal uptake of organic cations (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351871", "l": "Caspase-mediated cleavage of Z0-2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67155", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[NO transferase protein] <=> L-cysteinyl-[NO transferase protein] + S-nitroso-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13564", "l": "H2O + meso-2,6-diaminoheptanedioate + NADP(+) <=> (S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669863", "l": "Masitinib-resistant KIT mutants do not bind masitinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034828", "l": "4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018619", "l": "benzene 1,2-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0051734", "l": "polynucleotide kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592371", "l": "Initial activation of proMMP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981355", "l": "RASA1 binds RAS:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43979", "l": "H(+) + hexadecanoate + NADPH + O2 <=> 14-hydroxyhexadecanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42990", "l": "cembrene C + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047641", "l": "aldose-6-phosphate reductase (NADPH) activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102730", "l": "cathasterone hydroxylase activity"}, {"i": "MetaCyc:RXN-716"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0089702", "l": "undecaprenyl-phosphate glucose phosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228943", "l": "Transcytosis and dissociation of botA:NTNHA:HA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33790", "l": "3'-ketolactose + H2O <=> 3-keto-beta-D-galactose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450975", "l": "isocitrate <=> citrate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45122", "l": "H(+) + ipsdienone + NADH => (4R)-ipsdienol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164832", "l": "ATPase synthesizes ATP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65478", "l": "CoA + propyl butanoate => 1-propanol + butanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76052", "l": "Binding of TFIIIA To type 1 Promoter (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102421", "l": "curcumin-4'-O-beta-D-gentiobioside 1,6-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-13813"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050242", "l": "pyruvate, phosphate dikinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11240", "l": "ATP + thiamine diphosphate = ADP + thiamine triphosphate"}, {"i": "EC:2.7.4.15", "l": "\"Thiamine-diphosphate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47211", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39535", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA = (2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20576", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> calcitriol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607728", "l": "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32847", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycerol = a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212642", "l": "L-Glutamine transport into neurons (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55048", "l": "(3E,5Z)-dodecadienoyl-CoA + H2O = (3E,5Z)-dodecadienoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001850", "l": "complement component C3a binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55885", "l": "[aequorin] + 3 Ca(2+) => [aequorin]--dioxetanone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424482", "l": "p85 regulatory unit of PI3K binds p-6Y-SYK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71164", "l": "homogentisate + O2 => maleylacetoacetate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693356", "l": "CEMIP hydrolyses HA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624133", "l": "ARL3:GTP binds the UNC119B complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917730", "l": "Cargo Recognition And Sorting (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57313", "l": "H2O + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine => cytidine 5'-diphosphoramidate + H(+) + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014834", "l": "ROBO1,ROBO2 bind SLIT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10304", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP] = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP]"}, {"i": "EC:2.3.1.40", "l": "\"Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21697", "l": "N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008115", "l": "sarcosine oxidase activity"}, {"i": "KEGG.REACTION:R00610"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19040", "l": "an epoxide + H2O <=> an ethanediol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202692", "l": "PIP3 binds to RhoA and activates it (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44705", "l": "a 2,3-saturated acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944240", "l": "Association of procollagen type III (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26352", "l": "beta-L-galactose 1-phosphate + H2O <=> L-galactose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167076", "l": "2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61712", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + N(omega)-hydroxy-N(delta)-methyl-L-arginine = 2 [Fe(III)-cytochrome b5] + H2O + N(delta)-methyl-L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009282", "l": "CDK1 phosphorylates RUNX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36082", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647977", "l": "ICMT methylates S-Farn RAS proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75238", "l": "TRAIL binds TRAIL receptors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65263", "l": "verruculide C epoxide <=> 3-hydroxypentacecilide A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35611", "l": "menadiol + 2 O2 = 2 H(+) + menadione + 2 superoxide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904517", "l": "MgATP(2-) binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5622134", "l": "CRABP1 binds atRA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76494", "l": "POR reduces CYP450:Fe3+ to CYP450:Fe2+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0016174", "l": "NAD(P)H oxidase H2O2-forming activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25440", "l": "(2E,6E)-farnesyl diphosphate = delta-selinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66611", "l": "(tRNA)-3'-end (ribonucleoside 5'-phosphate)-(guanosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(adenosine 5'-phosphate) + H2O <=> GpCpCpA + H(+) + tRNA 3'-end (3'-phosphooxy-ribonucleotide)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13706", "l": "alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + UDP-N-acetyl-alpha-D-glucosamine => alpha-D-Man-(1->3)-[alpha-D-GlcNAc-(1->2)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034924", "l": "cis-3,4-phenanthrenedihydrodiol-4-carboxylate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.255", "l": "\"N-terminal amino-acid N(alpha)-acetyltransferase NatA\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610036", "l": "Defective GALE does not epimerise UDP-Gal to UDP-Glc (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46831", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) <=> 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11779", "l": "2 H(+) + O2 + octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin] <=> (9Z)-octadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163320", "l": "Association of mTERF with the termination sequence (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33469", "l": "ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+) => ergosta-5,7,24(28)-trien-3beta-ol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008195", "l": "phosphatidate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57093", "l": "AH2 + S-(methylsulfanyl)glutathione => A + glutathione + methanethiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371385", "l": "TNF-alpha is cleaved by ADAM17 (TACE) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606564", "l": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047479", "l": "trypanothione synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2545196", "l": "FN1 dimerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20781", "l": "ATP + GMP => ADP + GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2172678", "l": "PHF8 demethylates histone H4K20me1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59324", "l": "D-xylose + O2 = D-xylono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56409", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-(9Z-octadecaenoyl)-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375160", "l": "NCAM1 binds to ATP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46746", "l": "ADP + carboxyphosphate => ATP + hydrogencarbonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34259", "l": "(+)-larreatricin + AH2 + O2 = (+)-3'-hydroxylarreatricin + A + H2O"}, {"i": "EC:1.14.99.47", "l": "\"(+)-larreatricin hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22795", "l": "isonocardicin A <=> nocardicin A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16376", "l": "(R)-pantothenate + ATP <=> (R)-4'-phosphopantothenate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033509", "l": "USP9X binds Ub:PEX5L (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36908", "l": "(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + malonyl-CoA => (13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654163", "l": "Activated FGFR4 binds PLCG1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031013", "l": "troponin I binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013004", "l": "RHOA binds effectors at the ER membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606583", "l": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33253", "l": "6-kestotriose + beta-D-glucose => 2 sucrose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37493", "l": "CoA + H(+) + N-(4-coumaroyl)-L-homoserine lactone + S-methyl-5'-thioadenosine => 4-coumaroyl-CoA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12205", "l": "dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => 3alpha-hydroxy-3,5-dihydromonacolin L carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46544", "l": "2 [Fe(II)-cytochrome b5] + an N-acylsphinganine + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + an N-acylsphing-4-enine + 2 H2O"}, {"i": "EC:1.14.19.17", "l": "\"Sphingolipid 4-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26055", "l": "GTP + H(+) + valienol 1-phosphate = diphosphate + GDP-valienol"}, {"i": "EC:2.7.7.91", "l": "\"Valienol-1-phosphate guanylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-593685", "l": "Netrin-4 binds DCC/UNC5A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514865", "l": "cGMP dissociates from CNG channels (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27377", "l": "(R)-glycerate + ATP = (2R)-2-phosphoglycerate + ADP + H(+)"}, {"i": "EC:2.7.1.165", "l": "\"Glycerate 2-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59395", "l": "acetyl-CoA + L-seryl-[protein] <=> CoA + O-acetyl-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5218821", "l": "PDK1 phosphorylates PKC (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22331", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) <=> diphosphate + thiamine phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114284", "l": "Release of Cytochrome c from mitochondria (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57426", "l": "catechol + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => guaiacol + O2 + reduced [NADH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5333051", "l": "RPA1 binds HSF1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015660", "l": "formate efflux transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018571", "l": "2,3-dihydroxy-p-cumate dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798615", "l": "TP53 binds the TP53AIP1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033899", "l": "ribonuclease U2 activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53643", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-alpha-amorphene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24114", "l": "glutathione disulfide + H2O2 => 2 glutathione + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202111", "l": "AKT1 phosphorylates eNOS (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42543", "l": "uridine(13) in tRNA <=> pseudouridine(13) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942224", "l": "Filaggrin binds Keratin tonofilament:Desmosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20737", "l": "acetyl-CoA + glycine => (2S)-2-amino-3-oxobutanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692764", "l": "MAPK6 binds CCND3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050167", "l": "pantothenoylcysteine decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28993", "l": "N-acetylneuraminate(out) => N-acetylneuraminate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21432", "l": "(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18002", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a carboxylate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28151", "l": "acetyl-CoA + spermidine => CoA + H(+) + N(1)-acetylspermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21296", "l": "D-galactose + NAD(+) = D-galactono-1,4-lactone + H(+) + NADH"}, {"i": "EC:1.1.1.48", "l": "\"D-galactose 1-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110011", "l": "Binding of Grb10 to the insulin receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38748", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-octadecenoyl) ethanolamine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53988", "l": "H2O + O-phospho-L-threonyl-[myosin light chain] = L-threonyl-[myosin light chain] + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005078", "l": "MAP-kinase scaffold activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53401", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59090", "l": "(2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine => D-histidine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48690", "l": "D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl => H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12139", "l": "a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) <=> a (2E,4E)-dienoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48347", "l": "an N-acyl-sphingoid base + UDP-alpha-D-galactose <=> a D-galactosylceramide + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043827", "l": "tRNA (adenine-57, 58-N(1)-) methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004129", "l": "cytochrome-c oxidase activity"}, {"i": "RHEA:11436", "l": "4 [Fe(II)cytochrome c] + 4 H(+) + O2 = 4 [Fe(III)cytochrome c] + 2 H2O"}, {"i": "EC:7.1.1.9", "l": "\"Cytochrome-c oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19303", "l": "H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine => histamine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429767", "l": "Passive I- efflux mediated by SMCT1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64259", "l": "dodecanoyl-CoA + glycine <=> CoA + H(+) + N-dodecanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684806", "l": "Unknown kinase phosphorylates CLEC1B dimer:PDPN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874192", "l": "MBTPS2 (S2P) cleaves CREB3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34631", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced [adrenodoxin] = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin]"}, {"i": "EC:1.14.15.15", "l": "\"Cholestanetriol 26-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63543", "l": "H2O + neurotensin <=> L-leucine + neurotensin-(1-12)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014456", "l": "GDIs block activation of RHOG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21063", "l": "3,4-dichloroaniline + malonyl-CoA <=> CoA + N-(3,4-dichlorophenyl)malonamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180728", "l": "Association of Ran-GTP with importin-beta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005427", "l": "proton-dependent oligopeptide secondary active transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418858", "l": "RhoGTPase GEF's recruited to DCC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781840", "l": "ERCC6 binds stalled RNA Pol II (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39307", "l": "(2E,11Z,14Z)-eicosatrienoyl-CoA + H(+) + NADPH = (11Z,14Z)-eicosadienoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703436", "l": "STAT5-dependent PIM1 gene expression downstream of FLT3 ITD and fusion mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3149539", "l": "MTR transfers CH3 group from MTHF to cob(I)alamin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018423", "l": "protein C-terminal leucine carboxyl O-methyltransferase activity"}, {"i": "REACT:R-HSA-8856945", "l": "PP2A methylation by LCMT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37721", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23633", "l": "D-threo-isocitrate + NAD(+) => 2-oxoglutarate + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46297", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52960", "l": "hyocholate + UDP-alpha-D-glucuronate = hyocholoyl-24-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351849", "l": "Caspase-mediated cleavage of Etk (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33927", "l": "4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2 = 2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde"}, {"i": "EC:1.14.13.163", "l": "\"6-hydroxy-3-succinoylpyridine 3-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40426", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112727", "l": "Serine phosphorylation of STATs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168848", "l": "tBID binds to inactive BAK protein (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59612", "l": "beta-alanyl-L-ornithine + H2O = beta-alanine + L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66043", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14175", "l": "4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate => dimethylallyl diphosphate + L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052733", "l": "quinate 3-dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45540", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2396395", "l": "HSPG2 (perlecan) binds alpha-dystroglycan (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977237", "l": "IRAK2 binds to IRAK4 associated with activated TLR : MyD88 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16262", "l": "L-lysyl-[protein] + succinyl-CoA => CoA + H(+) + N(6)-succinyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28097", "l": "di-trans,octa-cis-undecaprenyl diphosphate + H2O <=> di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13656", "l": "[6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose <=> [6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177923", "l": "Sustained activation of SRC kinase by SHP2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63737", "l": "2-phenylacetaldehyde + H(+) + NADPH => 2-phenylethanol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18205", "l": "AH2 + O2 + progesterone = 11alpha-hydroxyprogesterone + A + H2O"}, {"i": "EC:1.14.99.14", "l": "\"Progesterone 11-alpha-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211239", "l": "Association of DFF40 with chromatin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21920", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine = Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP"}, {"i": "RHEA:28386", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP"}, {"i": "EC:2.7.8.13", "l": "\"Phospho-N-acetylmuramoyl-pentapeptide-transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11031", "l": "ATP + D-mannose <=> ADP + D-mannose 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17764", "l": "an aromatic primary alcohol + NADP(+) <=> an aromatic aldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204169", "l": "PDP dephosphorylates p-lipo-PDH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681314", "l": "Replication transcription complex binds SARS-CoV-1 genomic RNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32558", "l": "(2E)-geranyl diphosphate + H2O <=> (R)-alpha-terpineol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37817", "l": "2-methyl-4-chlorophenol + CO2 + pyruvate + succinate => (R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44107", "l": "decanal + H2O + NAD(+) <=> decanoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.198"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63391", "l": "2 A + Fe(II)-heme o + H2O <=> 2 AH2 + Fe(II)-heme a"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15067", "l": "agmatine + benzoate => H2O + N(4)-benzoylagmatine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379974", "l": "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10198", "l": "2-succinylbenzoate + H2O => (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12852", "l": "H2O + O-phospho-L-seryl-[myosin light chain] <=> L-seryl-[myosin light chain] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15392", "l": "ATP <=> 3',5'-cyclic AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21159", "l": "(2R)-2-phosphoglycerate + H2O <=> (R)-glycerate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46815", "l": "4,4-dimethyl-8,14-cholestadien-3beta-ol + H(+) + NADPH <=> 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983152", "l": "Transfer of ubiquitin from E1 to E2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60434", "l": "AH2 + cannabichromenate => A + cannabigerolate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21394", "l": "2-phenylacetate + 2 H(+) + NADH => 2-phenylacetaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873926", "l": "IFNG dimer binds IFNGR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8866851", "l": "CFTR transits to the plasma membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14969", "l": "S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.144", "l": "\"Trans-aconitate 2-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202731", "l": "JAM3 dimerises (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60389", "l": "Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.1.7", "l": "\"Ferredoxin--NAD(P)(+) reductase (naphthalene dioxygenase ferredoxin-specific)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2900756", "l": "NOTCH1 HD+PEST domain mutants bind JAG2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15607", "l": "H(+) + NH4(+) + pyruvate + sulfate => H2O + L-serine O-sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018665", "l": "4-hydroxyphenylacetate 1-monooxygenase activity"}, {"i": "MetaCyc:1.14.13.18-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187332", "l": "Cytosolic CMs translocate to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682967", "l": "WHSC1 binds DNA DSBs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749197", "l": "ORC1 binds to H4K20me2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10801", "l": "diphosphate + XMP => 5-phospho-alpha-D-ribose 1-diphosphate + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35579", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-[6-O-(4-O-beta-D-glucosyl-p-coumaroyl)-2-O-(beta-D-xylosyl)-beta-D-glucosyl]-5-O-(6-O-malonyl-beta-D-glucoside) = cyanidin 3-O-[6-O-(4-O-beta-D-glucosyl-p-coumaroyl)-2-O-(2-O-sinapoyl-beta-D-xylosyl)-beta-D-glucosyl]-5-O-(6-O-malonyl-beta-D-glucoside) + D-glucose"}, {"i": "EC:2.3.1.n12", "l": "\"Sinapoyl-beta-D-glucose:anthocyanin sinapoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070773", "l": "protein-N-terminal glutamine amidohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211960", "l": "CYP2U1 19-hydroxylates ARA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036041", "l": "Defective IDUA does not hydrolyse the unsulfated alpha-L-iduronosidic link in DS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "69.298854394597811", "identifiers": [{"i": "GO:0008170", "l": "N-methyltransferase activity"}, {"i": "EC:2.1.1.-", "l": "\"Methyltransferases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38948", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373075", "l": "Metabotropic glutamate receptors bind glutamate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047430", "l": "oligosaccharide-diphosphodolichol diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11648", "l": "(-)-menthol + H(+) + NADPH + O2 = 1,4-menthane-3,8-diol + H2O + NADP(+)"}, {"i": "EC:1.14.13.46", "l": "\"(-)-menthol monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23265", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NADP(+) => 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134914", "l": "Beta-catenin migrates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161282", "l": "Elastic fibres bind associated proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35622", "l": "L-idarate <=> D-glucarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50124", "l": "NAD(+) + resolvin D1 = 8-oxoresolvin D1 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58271", "l": "[protein]-C-terminal glycine + NAD(+) <=> [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725332", "l": "MYC/MYCN bind the ALK gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018808", "l": "RAC3 binds effectors at the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39805", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH => 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032558", "l": "adenyl deoxyribonucleotide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656259", "l": "Defective HEXA does not cleave the terminal GalNAc from DS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.31"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682026", "l": "MRN bound to shortened telomeres activates ATM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35433", "l": "4-hydroxy-3-methoxybenzoate + cyanidin 3,7-di-O-beta-D-glucoside => 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964759", "l": "Alternative endo-mannosidase I route (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004372", "l": "glycine hydroxymethyltransferase activity"}, {"i": "RHEA:15481", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine"}, {"i": "EC:2.1.2.1", "l": "\"Glycine hydroxymethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44406", "l": "H(+) + S-adenosyl-L-homocysteine + ubiquinol-7 => 3-demethylubiquinol-7 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34856", "l": "2 H2O + iminodiacetonitrile => N-(cyanomethyl)glycine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45495", "l": "[phycoerythrocyanin beta-subunit]-Cys(84)-phycocyanobilin <=> (2R,3E)-phycocyanobilin + apo-[phycoerythrocyanin beta-subunit]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16060", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32169", "l": "aerobactin + AMP + diphosphate + H(+) => ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130478", "l": "Interaction of invariant chain trimer and MHC II alpha beta dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-434650", "l": "MATEs mediate extrusion of xenobiotics (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004138", "l": "deoxyguanosine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31234", "l": "4-acetamidobutanal + H2O + NAD(+) <=> 4-acetamidobutanoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14955", "l": "(11Z)-tetradecenoyl-CoA + 2 H2O + NADP(+) => H(+) + NADPH + O2 + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36824", "l": "1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol => CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33998", "l": "gamma-L-glutamyl-butirosin B <=> 5-oxo-L-proline + butirosin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30620", "l": "2 A + all-trans-zeta-carotene => 2 AH2 + all-trans-lycopene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022359", "l": "MECP2:SIN3A complex binds GRIA2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19678", "l": "9'-cis-neoxanthin + O2 => (3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22027", "l": "H2O + NAD(+) + trimethylamine <=> 2 H(+) + NADH + trimethylamine N-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190829", "l": "Lysosomal degradation of gap junction plaques (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051408", "l": "glyceraldehyde 3-phosphate:inorganic phosphate antiporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050287", "l": "sorbose 5-dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56903", "l": "globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine <=> globoside GlcNAc-(beta1->6)-GalGb4Cer + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19286", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + di-trans,poly-cis-dolichol => a 1-acyl-sn-glycero-3-phosphocholine + acyldolichol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28838", "l": "citrate(out) + succinate(in) <=> citrate(in) + succinate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22086", "l": "2 NH4(+) + pyruvate => (S)-2,3-diaminopropanoate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19788", "l": "2-oxoglutarate + dihydroclavaminate + O2 <=> clavaminate + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59098", "l": "diglucosyl-enterobactin + H(+) + UDP => monoglucosyl-enterobactin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.115", "l": "\"Branched-dextran exo-1,2-alpha-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014433", "l": "RHOG GEFs activate RHOG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202702", "l": "CD177 binds PECAM-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2990882", "l": "CDK1 phosphorylates NUP98 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8870678", "l": "Cleaved fibrinogen products bind TLR4:LY96 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54002", "l": "(11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20868", "l": "alpha,alpha-trehalose + H2O = 2 D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53335", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 <=> 2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848939", "l": "PTK6 binds KHDRBS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-377640", "l": "Autophosphorylation of SRC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430135", "l": "p-SLP-76 binds ADAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45735", "l": "D-ribulose 5-phosphate + L-tyrosine <=> (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27738", "l": "2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + guanine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050594", "l": "tabersonine 16-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21377", "l": "3-(4-hydroxyphenyl)pyruvate + O2 => (S)-4-hydroxymandelate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52355", "l": "(24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate <=> (24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015067", "l": "amidinotransferase activity"}, {"i": "EC:2.1.4.-", "l": "\"Amidinotransferases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007631", "l": "E2F6 binds RBBP4 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341072", "l": "SUMOylation of RARA with SUMO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047025", "l": "3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity"}, {"i": "RHEA:19913", "l": "a (3R)-hydroxyacyl-[ACP] + NAD(+) = a 3-oxoacyl-[ACP] + H(+) + NADH"}, {"i": "EC:1.1.1.212", "l": "\"3-oxoacyl-[acyl-carrier-protein] reductase (NADH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168400", "l": "iE-DAP elicits a NOD1 response (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953013", "l": "E2F7 binds E2F8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74723", "l": "Endosome acidification (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58950", "l": "4-O-([3-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP => 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15492", "l": "adenosine + H2O + 2 O2 <=> 9-riburonosyladenine + H(+) + 2 H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10506", "l": "7alpha,12alpha-dihydroxycholest-4-en-3-one + H2O + NADP(+) => 7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350769", "l": "trans-Golgi Network Coat Activation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679045", "l": "C-ter TLR9 dimer binds HCQ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875591", "l": "DOCK7 activates RAC1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16972", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-4-dehydro-beta-L-rhamnose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56769", "l": "2 AH2 + all-trans-zeaxanthin + 2 O2 => 2 A + all-trans-adonixanthin + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33366", "l": "D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-mannitol 1-phosphate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164520", "l": "Minus strand DNA synthesis resumes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420233", "l": "VIP receptors bind VIP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22409", "l": "dimethylallyl diphosphate + isopentenyl diphosphate => (2E)-geranyl diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61933", "l": "(S)-miconazole(in) + ATP + H2O => (S)-miconazole(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352059", "l": "SLC6A15-mediated amino acid uptake (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48828", "l": "H(+) + NADPH + O2 + resorcinol = benzene-1,2,4-triol + H2O + NADP(+)"}, {"i": "EC:1.14.13.219", "l": "\"Resorcinol 4-hydroxylase (NADPH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64103", "l": "2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + TAN-1612"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13360", "l": "3-hydroxypropanoate + NAD(+) <=> 3-oxopropanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48664", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 12,20-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23163", "l": "L-rhamnopyranose <=> L-rhamnulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417829", "l": "P2RY12 binds ADP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12963", "l": "acetoacetyl-CoA + butanoate => acetoacetate + butanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49943", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2 <=> (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68615", "l": "Formation of ORC(1-6) complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24512", "l": "L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H2O"}, {"i": "EC:4.2.1.50", "l": "\"Pyrazolylalanine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43339", "l": "H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + n Na(+)(in) <=> CO2 + N(6)-biotinyl-L-lysyl-[protein] + n Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53662", "l": "(5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849435", "l": "PTPN1 dephosphorylates PTK6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19466", "l": "NADPH + 2 nitric oxide + 2 O2 => H(+) + NADP(+) + 2 nitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730882", "l": "Phosphorylation of PKC-theta (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849857", "l": "KLK5 cleaves and activates CELA2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41282", "l": "H2O + N-octadecanoylsphing-4-enine <=> octadecanoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29096", "l": "5 H(+)(in) + NADH + ubiquinone-8 => 4 H(+)(out) + NAD(+) + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46902", "l": "a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) (E. coli) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29505", "l": "diphosphate + patchoulol => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693540", "l": "MRN activates ATM (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9650473", "l": "SERPING1 is secreted (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683774", "l": "p-T68-CHEK2 dimerizes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952996", "l": "E2F7 forms homodimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24362", "l": "Fe(2+) + sirohydrochlorin => 2 H(+) + siroheme"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047031", "l": "diethyl 2-methyl-3-oxosuccinate reductase activity"}, {"i": "MetaCyc:1.1.1.229-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38289", "l": "(3S)-citramalyl-CoA + succinate => (3S)-citramalate + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1454916", "l": "The ABCC family mediates organic anion transport (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41716", "l": "a 2-acyl-sn-glycero-3-phospho-L-serine + H2O = a 2-acyl-sn-glycerol 3-phosphate + H(+) + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391158", "l": "SIRP alpha binds CD47 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24727", "l": "N-demethylindolmycin + S-adenosyl-L-methionine => H(+) + indolmycin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42451", "l": "(R)-2-hydroxyglutaryl-CoA <=> (2E)-glutaconyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12266", "l": "aureusidin + H2O => 2',4,4',6'-tetrahydroxychalcone + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.98.2", "l": "\"Bacteriochlorophyllide c C-7(1)-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26289", "l": "2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine = 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate"}, {"i": "EC:6.3.5.11", "l": "\"Cobyrinate a,c-diamide synthase (glutamine-hydrolyzing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24738", "l": "(6R)-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654792", "l": "Expression of GRB10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2889070", "l": "SLC9B2 exchanges Na+, Li+ for H+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31221", "l": "5-hydroxy-L-kynurenine + H(+) => 5-hydroxykynurenamine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65504", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + H2O = 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + [mycofactocin precursor peptide]-C-terminal glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39782", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40504", "l": "N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine => N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29076", "l": "formate(out) + 2 H(+)(in) + ubiquinone-8 => CO2(out) + H(+)(out) + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63738", "l": "2-phenylethanol + NADP(+) => 2-phenylacetaldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647978", "l": "pro-RAS proteins are farnesylated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956586", "l": "RUNX1-containing TAL1 complex binds the MYB gene enhancer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903880", "l": "17alpha-hydroxyprogesterone binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55325", "l": "11-cis-retinol + hexadecanoyl-CoA => 11-cis-retinyl hexadecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570528", "l": "SUMOylation of XPC with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174706", "l": "chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698988", "l": "Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65585", "l": "(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] => 8-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047556", "l": "3,4-dihydroxyphthalate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114254", "l": "CYCS binds to APAF1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14041", "l": "(R)-vicianin + H2O = mandelonitrile + vicianose"}, {"i": "EC:3.2.1.119", "l": "\"Vicianin beta-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035870", "l": "dITP diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58900", "l": "1-carboxybiuret + H2O = NH4(+) + urea-1,3-dicarboxylate"}, {"i": "EC:3.5.1.131", "l": "\"1-carboxybiuret hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22412", "l": "anthranilate + ATP = diphosphate + N-adenylylanthranilate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29262", "l": "(2R,3R)-tartrate(out) + succinate(in) <=> (2R,3R)-tartrate(in) + succinate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655483", "l": "USP1 autocleavage (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28047", "l": "phosphate + propanoyl-CoA => CoA + propanoyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41774", "l": "CMP + ganglioside GQ1b (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E))"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23247", "l": "propane-1,3-diamine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + norspermidine + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52760", "l": "(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O = (Z)-1-(glycyl-L-cystein-S-yl)-2-phenylacetohydroximate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33679", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + N-tetracosanoylsphinganine + O2 = 2 [Fe(III)-cytochrome b5] + H2O + N-tetracosanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.80", "l": "\"Streptogrisin A\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982792", "l": "Growth hormone receptor binds JAK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450187", "l": "TAK1 is activated within the TAK1 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168947", "l": "Ligand binds to TLR10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52089", "l": "5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA => 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0004955", "l": "prostaglandin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4568846", "l": "CDKN2A (p14-ARF) SUMOylates WRN with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250220", "l": "Homodimerization of ERBB4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12795", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP => 1D-myo-inositol hexakisphosphate + ATP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004067", "l": "asparaginase activity"}, {"i": "RHEA:21016", "l": "H2O + L-asparagine = L-aspartate + NH4(+)"}, {"i": "EC:3.5.1.1", "l": "\"Asparaginase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46806", "l": "a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + H(+) + S-adenosyl-L-homocysteine => a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606273", "l": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350604", "l": "Agmatine + H2O <=> putrescine + urea (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21754", "l": "all-trans-capsorubin => all-trans-violaxanthin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27826", "l": "hydrogen sulfide + O-succinyl-L-homoserine = L-homocysteine + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50040", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56953", "l": "CTP + pyruvate => CDP + H(+) + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64449", "l": "L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine => 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41202", "l": "1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400204", "l": "PPARA binds RXRA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14059", "l": "a monoacylglycerophospholipid + a triacyl-sn-glycerol => a 1,2-diacyl-sn-glycerol + a glycerophospholipid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17542", "l": "an aromatic primary alcohol + O2 => an aromatic aldehyde + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003958", "l": "NADPH-hemoprotein reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.-", "l": "\"Site specific endodeoxyribonucleases: cleavage is sequence specific\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21517", "l": "isopiperitenone => piperitenone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953556", "l": "E2F1 gene transcription is inhibited by E2F6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444100", "l": "PROT mediates L-proline uptake (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001057", "l": "RNA polymerase IV activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38580", "l": "dammarenediol-II + O2 + reduced [NADPH--hemoprotein reductase] => (20S)-protopanaxadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985594", "l": "MYO9B inactivates RHOA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047848", "l": "dephospho-[reductase kinase] kinase activity"}, {"i": "MetaCyc:DEPHOSPHO-REDUCTASE-KINASE-KINASE-RXN"}, {"i": "EC:2.7.11.3", "l": "\"Dephospho-[reductase kinase] kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54179", "l": "a long-chain fatty aldehyde + holo-[ACP] + NADP(+) <=> a long-chain fatty acyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.7.11", "l": "\"2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376141", "l": "Interaction of ABL with ROBO1:SLIT2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12755", "l": "dihydroxyacetone + H(+) + NADPH => glycerol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17942", "l": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate => 2-methyl-cis-aconitate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14716", "l": "A + keto-L-sorbose <=> 5-dehydro-D-fructose + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54872", "l": "(1S,4R)-menthone + H(+) + NADPH + O2 = (4S,7R)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59625", "l": "H2O + N(2)-(4-aminobutanoyl)-L-ornithine => 4-aminobutanoate + L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62840", "l": "GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34024", "l": "3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(+) => (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31737", "l": "3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 3-oxocholan-24-oyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39208", "l": "3-oxohexacosanoyl-CoA + H(+) + NADPH => (3R)-hydroxyhexacosanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28157", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34311", "l": "4-nitrocatechol + NADH + O2 = 2-hydroxy-1,4-benzoquinone + H2O + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019158", "l": "mannokinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42632", "l": "adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + 8-methyladenosine(2503) in 23S rRNA + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.224", "l": "\"23S rRNA (adenine(2503)-C(8))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37692", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA => 1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696822", "l": "AKR1B15 reduces EST17b to E1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n12"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39694", "l": "(2E,11Z)-octadecadienoyl-CoA + H(+) + NADPH <=> (11Z)-octadecenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34101", "l": "CO2 + norspermidine => carboxynorspermidine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44461", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol => a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32265", "l": "L-alanine + succinate semialdehyde => 4-aminobutanoate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782943", "l": "UV-DDB ubiquitinates XPC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54886", "l": "H(+) + N(omega)-(2'-phospho-ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide => L-arginyl-[protein] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30653", "l": "allantoin + CO2 + H2O2 => 2 H2O + O2 + urate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75081", "l": "Formation of AT-AC B Complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48634", "l": "5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22387", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O <=> 1D-myo-inositol hexakisphosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16003", "l": "IMP + methylamine => H(+) + H2O + N(6)-methyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18072", "l": "L-arginine <=> D-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3266557", "l": "Factor I cleaves iC3b (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024723", "l": "EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49429", "l": "CTP + phosphonoformate => CMP-5'-phosphonoformate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24094", "l": "2 (2S)-bisdechlorogeodin + 2 H2O => 2 H(+) + O2 + 2 sulochrin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41003", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9650473", "l": "SERPING1 is secreted (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55067", "l": "4-methylpentanoyl-CoA + H2O <=> 4-methylpentanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29913", "l": "ADP + H(+) + N-acetyl-D-glucosamine(out) + phosphate => ATP + H2O + N-acetyl-D-glucosamine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709547", "l": "ESTG binds ESR2:chaperone complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65295", "l": "2 ATP + butan-2-one + 3 H2O + hydrogencarbonate <=> 3-oxopentanoate + 2 AMP + 4 H(+) + 4 phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0140489", "l": "molecular template activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63883", "l": "2 [Fe(III)cytochrome c] + H2O + thiocyanate <=> 2 [Fe(II)cytochrome c] + cyanate + 2 H(+) + sulfur"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167072", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009401", "l": "RUNX2 binds SMURF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74748", "l": "De-phosphorylation of p-Y427-SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35099", "l": "fusidate(in) + H(+)(out) = fusidate(out) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38767", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63537", "l": "[des-Arg(9)]-bradykinin + H2O => [des-Phe(8), des-Arg(9)]-bradykinin + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16823", "l": "6-phospho-2-dehydro-D-gluconate + H(+) + NADH => 6-phospho-D-gluconate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114354", "l": "SMAC binds XIAP:Caspase-7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5213464", "l": "RIPK1 is phosphorylated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433454", "l": "Phosphorylation of GAB2 by SFKs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867613", "l": "PICALM binds R-SNAREs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43959", "l": "15-methylhexadecanoate + H(+) + NADPH + O2 <=> H2O + NADP(+) + omega-hydroxy-15-methyl-hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18346", "l": "a cis-3-alkyl-4-alkyloxetan-2-one => a cis-alkene + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.43", "l": "\"Prepilin peptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61515", "l": "malvidin + UDP-alpha-D-glucose <=> malvidin 3-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32216", "l": "(6R)-NADHX => (6S)-NADHX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949580", "l": "F1Fo ATP synthase dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200143", "l": "AKT phosphorylates AKT1S1 (PRAS40) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186780", "l": "PI3-kinase binds to the active receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866851", "l": "CFTR transits to the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65488", "l": "3 ATP = 2',3',3'-c-tri-AMP + 3 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174070", "l": "Association of Cdh1 with the APC/C (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41743", "l": "adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102381", "l": "stevioside glucosyltransferase activity (rebaudioside A forming)"}, {"i": "MetaCyc:RXN-13517"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30542", "l": "(R)-carnitinyl-CoA <=> (S)-carnitinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25801", "l": "H2O + N(1)-acetylspermine + O2 => 3-acetamidopropanal + H2O2 + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2317332", "l": "PIP3 recruits AKT to the membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873921", "l": "Binding of STAT1 to p-IFNGR1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26212", "l": "L-allo-threonine <=> acetaldehyde + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13224", "l": "(R)-mevalonate + NAD(+) <=> H(+) + mevaldate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34610", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-15-methylhexadecasphing-4-enine <=> a 1,2-diacyl-sn-glycerol + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51553", "l": "D-sorbitol + NADP(+) => H(+) + L-xylo-3-hexulose + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36074", "l": "6-tuliposide A <=> D-glucose + tulipalin A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013024", "l": "RHOB binds effectors at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654224", "l": "Activated FGFR3 binds PLCG1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47647", "l": "adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793275", "l": "CMVPP65 binds NCR3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26430", "l": "(+)-copalyl diphosphate + H2O = diphosphate + phyllocladan-16alpha-ol"}, {"i": "EC:4.2.3.45", "l": "\"Phyllocladan-16-alpha-ol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19916", "l": "a (3R)-hydroxyacyl-[ACP] + NAD(+) <=> a 3-oxoacyl-[ACP] + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43096", "l": "guanosine(2535) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(2535) in 23S rRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.209", "l": "\"23S rRNA (guanine(2535)-N(1))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51148", "l": "a primary alcohol + 2 oxidized [azurin] = an aldehyde + 2 H(+) + 2 reduced [azurin]"}, {"i": "EC:1.1.9.1", "l": "\"Alcohol dehydrogenase (azurin)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53204", "l": "17beta,19-dihydroxy-3-oxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] = 17beta-hydroxy-3,19-dioxo-5alpha-androstanone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39600", "l": "3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437129", "l": "ZnT7 transports zinc into the golgi apparatus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183052", "l": "CBL binds to GRB2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63546", "l": "kinetensin-(1-8) + L-leucine => H2O + kinetensin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55576", "l": "4-hydroxy-N-methyltryptamine 4-phosphate + S-adenosyl-L-methionine = H(+) + psilocybin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174931", "l": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013009", "l": "RHOA binds effectors at the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392530", "l": "p-S400-Cot phosphorylates NIK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1299359", "l": "Activation of TALK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034056", "l": "estrogen response element binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070635", "l": "nicotinamide riboside hydrolase activity"}, {"i": "MetaCyc:RXN-8441"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61651", "l": "ATP + holo-[non-ribosomal peptide synthase] + salicylate <=> AMP + diphosphate + salicyl-[non-ribosomal peptide synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47910", "l": "6-deoxy-6-sulfo-D-gluconate + H(+) => 6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102002", "l": "valine N-monooxygenase (oxime forming) activity"}, {"i": "RHEA:28606", "l": "L-valine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-2-methylpropanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.38", "l": "\"Valine N-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48067", "l": "ganglioside GD1b (d18:1(4E)) + H2O <=> ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51565", "l": "cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14222", "l": "H2O + monomethyl sulfate => H(+) + methanol + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58171", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-5-epi-eremophilene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6796647", "l": "TP53 stimulates CCNK expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169398", "l": "ISGylation of host protein filamin B (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15646", "l": "16 ATP + 16 H2O + N2 + 4 reduced [flavodoxin] => 16 ADP + 18 H(+) + H2 + 2 NH4(+) + 4 oxidized [flavodoxin] + 16 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682826", "l": "LGI1 binds ADAM11 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44115", "l": "hexadecanoyl-CoA + nonan-1-ol <=> CoA + nonyl hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33015", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + H(+) + NADPH + O2 = [(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + H2O + NADP(+)"}, {"i": "EC:1.14.13.160", "l": "\"(2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA 1,5-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102415", "l": "quercetin gentiobioside 1,6-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-13798"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851933", "l": "MET phosphorylates GAB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.377", "l": "\"L-rhamnose 1-dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13563", "l": "(S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+) => H2O + meso-2,6-diaminoheptanedioate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12242", "l": "6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+) => acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062059", "l": "FACT complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13010", "l": "H2O + N-formyl-L-kynurenine => formate + H(+) + L-kynurenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59806", "l": "D-phenylalanine => L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28735", "l": "H(+)(in) + spermidine(out) = H(+)(out) + spermidine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15104", "l": "H(+) + meso-2,6-diaminoheptanedioate <=> CO2 + L-lysine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001601", "l": "peptide YY receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373707", "l": "Netrin-1 induced DCC clustering (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060308", "l": "GTP cyclohydrolase I regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198563", "l": "IDO1 dioxygenates L-Trp to NFK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40508", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O => a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446364", "l": "Migfilin interacts with VASP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.35"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59548", "l": "N,N',N''-triacetylchitotriose + O2 = H2O2 + N,N',N''-triacetylchitotriono-1,5-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-429036", "l": "SLC2A9 transports Fru, Glc, urate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198756", "l": "ERK1/2 phosphorylates MSK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51040", "l": "indole-3-pyruvate imine dimer = chromopyrrolate + H(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0046920", "l": "alpha-(1->3)-fucosyltransferase activity"}, {"i": "REACT:R-HSA-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000985", "l": "bacterial-type RNA polymerase core promoter sequence-specific DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50962", "l": "H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine => cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000399", "l": "RANBP2 SUMOylates SP100 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62175", "l": "an N-acylethanolamine phosphate + H2O <=> an N-acylethanolamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15942", "l": "H2O + N(2)-acetyl-L-ornithine => acetate + L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404144", "l": "Parenchymal atROL translocates to HSCs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879594", "l": "SLCO4C1 mediates the transport of digoxin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665708", "l": "ERBB2 TMD/JMD mutants do not bind pertuzumab (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20255", "l": "dimethylmaleate + H2O => (2R,3S)-2,3-dimethylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8934446", "l": "Activated PKC phosphorylates SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807578", "l": "GNLY binds the bacterial cell surface in the phagosome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29254", "l": "2 H(+)(out) + Na(+)(in) <=> 2 H(+)(in) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17281", "l": "(2S)-4-acetamido-2-aminobutanoate = H2O + L-ectoine"}, {"i": "EC:4.2.1.108", "l": "\"Ectoine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65344", "l": "H(+) + oxidized [electron-transfer flavoprotein] + valproyl-CoA = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45809", "l": "galactarate => (2S,3R)-dihydroxy-5-oxohexanedioate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016993", "l": "precorrin-8X methylmutase activity"}, {"i": "RHEA:22512", "l": "3 H(+) + precorrin-8X = hydrogenobyrinate"}, {"i": "EC:5.4.99.61", "l": "\"Precorrin-8X methylmutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62910", "l": "H(+) + S-adenosyl-L-homocysteine + toralactone => nor-toralactone + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32936", "l": "a cardiolipin + H2O => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34924", "l": "nitrate(in) => nitrate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47190", "l": "[methyl-Co(III) methylated-thiol-specific corrinoid protein] + hydrogen sulfide => [Co(I) methylated-thiol-specific corrinoid protein] + methanethiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19638", "l": "D-nopaline + H2O + NADP(+) => 2-oxoglutarate + H(+) + L-arginine + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59897", "l": "ATP + L-glutamate + L-propargylglycine => ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177284", "l": "PKA phosphorylates PDE4B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804229", "l": "JMY, TTC5 and EP300 bind (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34722", "l": "15-methylhexadecasphing-4-enine 1-phosphate <=> (2E)-13-methyltetradecenal + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30423", "l": "(2E,6E)-farnesyl diphosphate = (+)-delta-selinene + diphosphate"}, {"i": "EC:4.2.3.76", "l": "\"(+)-delta-selinene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34820", "l": "dihydrocurcumin + NADP(+) => curcumin + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28828", "l": "L-ornithine(out) + putrescine(in) => L-ornithine(in) + putrescine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50198", "l": "(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23853", "l": "catechol + O2 => cis,cis-muconate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706298", "l": "Active FLT3 binds to CSK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665871", "l": "ADRM1 binds 26S proteasome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66605", "l": "a 2'-deoxycytidine in double-stranded DNA + H(+) + H2O => a 2'-deoxyuridine in double-stranded DNA + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35259", "l": "7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O = 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981657", "l": "IL34 dimer binds PTPRZ1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607002", "l": "Activated protein C cleaves factor VIIIa (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42468", "l": "2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O = 2-oxopent-4-enoate + salicylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375149", "l": "Interaction of NCAM1 with GFRalpha-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952419", "l": "SMURFs ubiquitinate RUNX3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64799", "l": "H2O + L-lysine + NADP(+) <=> (S)-2-amino-6-oxohexanoate + H(+) + NADPH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449077", "l": "Interleukin-16 is secreted (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977619", "l": "CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448678", "l": "CTSG cleaves CASP1(1-404) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373732", "l": "Nephrin trans-homophilic interaction (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000224", "l": "peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"}, {"i": "REACT:R-HSA-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43696", "l": "H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate = diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]"}, {"i": "EC:2.7.4.27", "l": "\"([Pyruvate, phosphate dikinase] phosphate) phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64054", "l": "CoA + H(+) + N-(13Z-docosenoyl)-4R-hydroxysphinganine => (13Z)-docosenoyl-CoA + (4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75080", "l": "Formation of AT-AC A complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20205", "l": "methylazoxymethanol + UDP-alpha-D-glucose = cycasin + H(+) + UDP"}, {"i": "EC:2.4.1.171", "l": "\"Methyl-ONN-azoxymethanol beta-D-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57421", "l": "NADH + 2 oxidized [cytochrome P450] => H(+) + NAD(+) + 2 reduced [cytochrome P450]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9640195", "l": "RRAGA,B hydrolyzes GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54579", "l": "2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2 <=> an adenosine in tRNA + CO2 + formaldehyde + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035478", "l": "chylomicron binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.23", "l": "\"Matrilysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009378", "l": "four-way junction helicase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1861789", "l": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030733", "l": "fatty acid O-methyltransferase activity"}, {"i": "RHEA:23012", "l": "a fatty acid + S-adenosyl-L-methionine = a fatty acid methyl ester + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.15", "l": "\"Fatty-acid O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31929", "l": "2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12953", "l": "ATP + L-seryl-[Goodpasture antigen-binding protein] = ADP + H(+) + O-phospho-L-seryl-[Goodpasture antigen-binding protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30245", "l": "2 H2O + 4 monodehydro-L-ascorbate radical => 4 L-ascorbate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870628", "l": "Phosphorylated FOXO3 translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-432067", "l": "Aquaporin-4 passively transports water out of cell (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29404", "l": "6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + AH2 + O2 => 3-demethylubiquinol-8 + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51098", "l": "19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874209", "l": "CREB3L4 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57988", "l": "(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose = (20S)-ginsenoside F2 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51183", "l": "cytidine(49) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(49) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53291", "l": "3-dehydro-scyllo-inosose + H2O <=> 5-dehydro-L-gluconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35279", "l": "acetyl-CoA + hexadecanoyl-CoA = 3-oxooctadecanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47606", "l": "CMP + ganglioside GP1calpha (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E))"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50349", "l": "alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => dolichyl diphosphate + H(+) + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53812", "l": "cholestanol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-26-hydroxycholestanol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64535", "l": "2 [Fe(II)-cytochrome b5] + an N-(1,2 saturated very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602466", "l": "Activation of MT-MMPs by FURIN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216136", "l": "Formation of the CI:SU(FU) complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.5", "l": "\"Ribonuclease P\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20826", "l": "ADP + AMP + H(+) => adenosine + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-877281", "l": "PIAS1 binds p-STAT1 dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17240", "l": "ATP + FMN + H(+) <=> diphosphate + FAD"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40324", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25766", "l": "(2R,3S)-3-methylmalate + NAD(+) <=> 3-carboxy-2-oxobutanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22125", "l": "17-O-acetylajmaline + H2O => acetate + ajmaline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22098", "l": "a ribonucleoside 5'-diphosphate + RNA(n) => phosphate + RNA(n+1)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31241", "l": "4 CO2 + coproporphyrinogen I => 4 H(+) + uroporphyrinogen I"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380002", "l": "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14739", "l": "3',5'-cyclic CMP + diphosphate => CTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168640", "l": "Ubiquitinated IkB is degraded (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209910", "l": "Iodide is taken up by thyroid epithelial cells (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16035", "l": "CO2 + gibberellin A19 + H2O + succinate => 2-oxoglutarate + gibberellin A44 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52916", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140769", "l": "factor VII -> factor VIIa (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22948", "l": "D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate"}, {"i": "EC:4.1.2.40", "l": "\"Tagatose-bisphosphate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35174", "l": "H(+)(out) + novobiocin(in) <=> H(+)(in) + novobiocin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30850", "l": "FAD + glutaryl-CoA + 2 H(+) <=> (2E)-butenoyl-CoA + CO2 + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69053", "l": "RFC binding displaces Pol Alpha (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48673", "l": "20-oxo-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37086", "l": "[sulfur carrier]-SH + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + S-adenosyl-L-methionine <=> [sulfur carrier]-H + H(+) + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10562", "l": "2,5-dioxopentanoate + NH4(+) => 4-hydroxy-1-pyrroline-2-carboxylate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433456", "l": "Recruitment of STATs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31223", "l": "cis-beta-D-glucosyl-2-hydroxycinnamate + H2O = beta-D-glucose + cis-2-coumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58986", "l": "acrylate + H(+) + H2O2 => acrolein + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013147", "l": "RAC1 GDIs block activation of RAC1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139899", "l": "Sequestration of BAD protein by 14-3-3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43772", "l": "guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.264", "l": "\"23S rRNA (guanine(2069)-N(7))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018599", "l": "2-hydroxyisobutyrate 3-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139895", "l": "tBID activates BAK protein (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2529020", "l": "CK2 phosphorylates condensin I subunits (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0019210", "l": "kinase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10085", "l": "3,4-dihydroxybenzoate + O2 => 3-carboxy-cis,cis-muconate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37959", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54900", "l": "(2E)-hexadecenoyl-[ACP] + H(+) + NADH = hexadecanoyl-[ACP] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27469", "l": "H2O + N,N'-diacetylchitobiose = acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine"}, {"i": "EC:3.5.1.105", "l": "\"Chitin disaccharide deacetylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940134", "l": "FOLR2 binds FOLA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56740", "l": "globoside Gb3Cer + UDP-alpha-D-galactose = GalGb3Cer + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30538", "l": "biotinate sulfoxide + H(+) + NADPH <=> biotin + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60245", "l": "2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] => 2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21249", "l": "a ribonucleoside 5'-triphosphate + RNA(n) => diphosphate + RNA(n+1)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33491", "l": "2-hydroxyhexacosanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxyhexacosanoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50540", "l": "prostaglandin A2 = prostaglandin C2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018774", "l": "RHOBTB1 binds GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170120", "l": "Translocation of Cdc25B to the cytoplasm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13025", "l": "3-methyl-(2E)-butenoyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = N(6)-biotinyl-L-lysyl-[protein] + trans-3-methylglutaconyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983298", "l": "IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617877", "l": "HOXA4 gene is transcribed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14134", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] => 16-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57818", "l": "2-deoxy-D-ribose 5-phosphate + guanine => dGMP + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070523", "l": "11-beta-hydroxysteroid dehydrogenase (NAD+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296127", "l": "Activation of voltage gated Potassium channels (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9656947", "l": "OGG1beta translocates to mitochondria (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48023", "l": "globoside Gb3Cer + H2O <=> beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1458485", "l": "RALA hydrolyzes GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31892", "l": "2-hydroxy-1-phenyl-1-propanone + NADP(+) => 1-phenyl-1,2-propanedione + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29237", "l": "a menaquinol + NAD(+) => a menaquinone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373707", "l": "Netrin-1 induced DCC clustering (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5444516", "l": "Formation of MSH2:MSH6 Complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607043", "l": "factor VIIIa associates with cell membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061750", "l": "acid sphingomyelin phosphodiesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237119", "l": "Acireductone is oxidized to MOB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173626", "l": "Activation of C1r (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23476", "l": "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O"}, {"i": "EC:4.1.1.48", "l": "\"Indole-3-glycerol-phosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46877", "l": "[(1->4)-beta-D-mannuronosyl](n) + GDP-alpha-D-mannuronate => [(1->4)-beta-D-mannuronosyl](n+1) + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17715", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + salutaridine => (R)-reticuline + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52322", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + serotonin => O2 + reduced [NADPH--hemoprotein reductase] + tryptamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060703", "l": "deoxyribonuclease inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625197", "l": "GFAP binds LAMP2a multimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70494", "l": "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877485", "l": "RUNX1 binds to TNFRSF18 (GITR) gene promoter and intron 1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.17", "l": "\"Nitric oxide dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800798", "l": "The PIDDosome binds CASP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21642", "l": "3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH => NADP(+) + prephenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204873", "l": "Interaction of Tie2 and Shp2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46075", "l": "(2E)-hexadecenoyl-CoA + H(+) + NADH <=> hexadecanoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32583", "l": "dihydrocarvone + H(+) + NADPH + O2 = 6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19828", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-aristolochene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1299338", "l": "Activation of TRESK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3296233", "l": "T2Rs bind bitter-tasting compounds (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852552", "l": "MST1R autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49087", "l": "(-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442749", "l": "CaMKK autophosphorylates in the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-984671", "l": "Chromokinesins form dimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54830", "l": "formaldehyde + H2O + methylamine + NADP(+) => dimethylamine + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047715", "l": "hypotaurocyamine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5082391", "l": "Trimerization of HSF1 in the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5658438", "l": "SPRED dimer binds NF1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047901", "l": "formyl-CoA hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.73", "l": "\"Jararhagin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3828025", "l": "DCN (decorin) degradation by MMP14 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14504", "l": "H2O + L-homocysteine <=> 2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58759", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + H(+) + NADPH <=> 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8871260", "l": "YAP1 binds TEAD2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017491", "l": "RHOJ GEFs activate RHOJ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17078", "l": "H2O + N,N-dimethylglycine + O2 => formaldehyde + H2O2 + sarcosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613207", "l": "EGR1 binds to the EGR1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47013", "l": "[DsrC protein]-disulfide + H(+) + hydrogen sulfide => [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22756", "l": "a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2"}, {"i": "EC:1.1.3.20", "l": "\"Long-chain-alcohol oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22911", "l": "3',5'-cyclic AMP + H(+) + H2O <=> 3',5'-cyclic IMP + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13893", "l": "H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate = ADP + AMP + 2 H(+)"}, {"i": "EC:3.6.1.29", "l": "\"Bis(5'-adenosyl)-triphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675910", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38043", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (4Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.19.11", "l": "\"Acyl-[acyl-carrier-protein] 4-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985201", "l": "ABCE1 binds RNASEL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3318415", "l": "ATF2 acetylates histone H2B, H4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102804", "l": "oripavine 6-O-demethylase activity"}, {"i": "MetaCyc:RXN-8151"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23065", "l": "an alkanesulfonate + FMNH2 + O2 => an aldehyde + FMN + 2 H(+) + H2O + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182990", "l": "Sprouty sequesters CBL away from active EGFR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388832", "l": "PI3K binds CD28 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802921", "l": "Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55120", "l": "4-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-4-methylhexanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "81.20444558259193", "identifiers": [{"i": "GO:0005254", "l": "chloride channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45442", "l": "H(+) + N-eicosanoyl ethanolamine + sn-glycerol 3-phosphate => H2O + N-eicosanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202714", "l": "CD58 binds CD2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371567", "l": "DBC1 is phosphorylated by ATM/ART (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10740", "l": "a secondary alcohol + NAD(+) = a ketone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14535", "l": "creatine => creatinine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2430535", "l": "MASTL phosphorylates ENSA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43380", "l": "H2O + N(omega)-phospho-L-arginyl-[protein] = L-arginyl-[protein] + phosphate"}, {"i": "EC:3.9.1.2", "l": "\"Protein arginine phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11342", "l": "4-guanidinobutanal + CO2 => 5-guanidino-2-oxopentanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.20.98.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937419", "l": "CBR3 reduces DOX to DOXOL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-190519", "l": "Internalization of gap junction plaques (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53599", "l": "1-octadecanoyl-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13894", "l": "H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate => ADP + AMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061685", "l": "diphthine methylesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50607", "l": "acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18688", "l": "H(+) + NADPH + O2 + pentachlorophenol <=> 2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928615", "l": "EFNBs bind SFKs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030792", "l": "methylarsonite methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0023031", "l": "MHC class Ib protein binding, via lateral surface"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46678", "l": "(6R)-2,2,6-trimethyl-1,4-cyclohexanedione + H(+) + NADH => (4R)-hydroxy-(6R)-2,2,6-trimethylcyclohexanone + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58155", "l": "H2O + NAD(+) + phosphonoacetaldehyde <=> 2 H(+) + NADH + phosphonoacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61715", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + N(omega)-hydroxy-N(delta)-methyl-L-arginine <=> 2 [Fe(III)-cytochrome b5] + H2O + N(delta)-methyl-L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63061", "l": "5-methylorsellinate + ATP + H(+) + NADPH => 2,4-dihydroxy 5,6-dimethylbenzaldehyde + AMP + diphosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58083", "l": "1-docosanoylglycerol + H2O <=> docosanoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3777129", "l": "HDAC3 containing complexes deacetylate histone (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66840", "l": "asperterpenoid A + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = asperterpenoid B + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40640", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H2O => (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35970", "l": "fumitremorgin C + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 12alpha,13alpha-dihydroxyfumitremorgin C + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879248", "l": "desacetylmycothiol is acetylated to mycothiol using acetyl-CoA (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52764", "l": "(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O = (E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate"}, {"i": "EC:3.4.19.16", "l": "\"Glucosinolate gamma-glutamyl hydrolase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042131", "l": "thiamine phosphate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56796", "l": "[corrinoid adenosyltransferase]-cob(I)alamin + ATP = adenosylcob(III)alamin + apo-[corrinoid adenosyltransferase] + triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008054", "l": "IL1F10 binds IL1RAPL1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70596", "l": "GOT2 dimer deaminates L-Asp (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52020", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 = A + H2O + resolvin E2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34072", "l": "trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49990", "l": "H2O + methyl acetate + NADP(+) => acetone + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16367", "l": "2 3,4,5-trihydroxybenzoate + H(+) => digallate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156682", "l": "PLK1 phosphorylates NUDC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54295", "l": "ATP + L-threonyl-[protein] <=> 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396370", "l": "VTN binds collagens II, III and V (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.38", "l": "\"Beta-D-fucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203662", "l": "eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44503", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9641111", "l": "Parkin transfers Ub to misfolded proteins (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54431", "l": "4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O <=> ADP-D-ribose + H(+) + L-aspartyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3341294", "l": "Superoxide reduces cytochrome c (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685156", "l": "ATR phosphorylates RPA2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38291", "l": "(S)-malyl-CoA + H2O = (S)-malate + CoA + H(+)"}, {"i": "EC:3.1.2.30", "l": "\"(3S)-malyl-CoA thioesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33007", "l": "(+)-artemisinic alcohol + O2 + reduced [NADPH--hemoprotein reductase] = (+)-artemisinic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57953", "l": "H(+) + NADH + O2 + phenol => catechol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64556", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one = 8-epi-ilicicolin H"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.3", "l": "\"Ribonuclease III\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65611", "l": "(4R)-hydroxysphinganine + docosanoyl-CoA <=> CoA + H(+) + N-docosanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33814", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 glycine + 3 L-threonine <=> 6 AMP + corynebactin + 6 diphosphate + 3 H(+) + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050525", "l": "cutinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52529", "l": "2-oxoglutarate + L-asparagine => 2-oxosuccinamate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102858", "l": "1-18:2-2-18:3-phosphatidylcholine desaturase activity"}, {"i": "MetaCyc:RXN-8325"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24133", "l": "UDP-alpha-D-galactose => UDP-alpha-D-galactofuranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110011", "l": "Binding of Grb10 to the insulin receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32768", "l": "cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine => 2'-O-methylcytidine(4) in tRNA(Pro) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-378952", "l": "Thyrotropin is a heterodimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39058", "l": "22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22735", "l": "4-hydroxyphenylacetate + H(+) <=> 4-methylphenol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34280", "l": "di-trans,poly-cis-dolichol + NADP(+) => di-trans,cis-polyprenol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24847", "l": "cyclobis-(1->3)-alpha-isomaltosyl + 2 H2O <=> 2 isomaltose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53896", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc-R + CMP + H(+)"}, {"i": "EC:2.4.99.7", "l": "\"Alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide 6-alpha-sialyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13703", "l": "CoA + O-acetyl-L-homoserine => acetyl-CoA + L-homoserine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46296", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033877", "l": "succinyl-CoA:(R)-benzylsuccinate CoA-transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29557", "l": "alpha-D-glucose 1-phosphate + 2 H(+) + UMP => H2O + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47220", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] = 3beta,16alpha-dihydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102864", "l": "1-18:3-2-18:2-phosphatidylcholine desaturase activity"}, {"i": "MetaCyc:RXN-8331"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047046", "l": "homoisocitrate dehydrogenase activity"}, {"i": "RHEA:11900", "l": "(1R,2S)-homoisocitrate + NAD(+) = 2-oxoadipate + CO2 + NADH"}, {"i": "EC:1.1.1.87", "l": "\"Homoisocitrate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62859", "l": "GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36392", "l": "cholesterol + NADP(+) => cholesta-5,24-dien-3beta-ol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13630", "l": "(1S,5R)-carveol + NADP(+) => (R)-carvone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928607", "l": "p-EPHs bind VAV2,3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66794", "l": "(3R)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2 => N-methyl-D-dopa + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38606", "l": "NADP(+) <=> 2'-phospho-cyclic ADP-ribose + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59107", "l": "chenodeoxycholate + dolichyl beta-D-glucosyl phosphate <=> beta-D-glucosyl-(1->3)-O-chenodeoxycholate + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15166", "l": "H2O + O2 + sarcosine => glyoxylate + H2O2 + methylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59908", "l": "H2O + hexanal + NADP(+) = 2 H(+) + hexanoate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202947", "l": "Caspase mediated cleavage of APC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29674", "l": "Ca(2+)(in) <=> Ca(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38725", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31025", "l": "dammara-20,24-diene => squalene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65325", "l": "acetyl-CoA + chrodrimanin A => chrodrimanin B + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000310", "l": "AURKA phosphorylates PLK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "81.20444558259193", "identifiers": [{"i": "GO:0099604", "l": "ligand-gated calcium channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404133", "l": "A REH hydrolses atREs to atROL and FAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11027", "l": "ATP + NH4(+) <=> ADP + 2 H(+) + phosphoramidate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110360", "l": "Recruitment of POLB to the AP site (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1878002", "l": "XYLTs transfer Xyl to core protein (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042834", "l": "peptidoglycan binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102688", "l": "dihydrozeatin UDP glycosyltransferase activity"}, {"i": "MetaCyc:RXN-4725"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27851", "l": "glycine + phenylacetyl-CoA => CoA + H(+) + phenylacetylglycine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047664", "l": "aminoimidazolase activity"}, {"i": "RHEA:22348", "l": "4-aminoimidazole + H(+) + H2O = imidazol-4-one + NH4(+)"}, {"i": "EC:3.5.4.8", "l": "\"Aminoimidazolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362793", "l": "Hh-Np is cleaved by ADAM17 to promote ligand shedding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956639", "l": "RUNX1 binds YAP1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55083", "l": "ADP-alpha-D-glucose + D-fructose <=> ADP + H(+) + sucrose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34440", "l": "2,3-didehydroadipyl-CoA + acetyl-CoA => 3-oxo-5,6-didehydrosuberyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198440", "l": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.30", "l": "\"Isobutylamine N-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0043177", "l": "organic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31089", "l": "3-oxodecanoyl-CoA + CoA => acetyl-CoA + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61488", "l": "cytidine(50) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(50) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193650", "l": "p75NTR binds to NADE (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004043", "l": "L-aminoadipate-semialdehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199014", "l": "CD96 binds PVR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45257", "l": "hexadecanoate(out) => hexadecanoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27898", "l": "3'-AMP + H2O = adenosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10557", "l": "D-glyceraldehyde 3-phosphate + L-arginine => H(+) + N(2)-(2-carboxyethyl)-L-arginine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647980", "l": "mature RAS proteins translocate to plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445064", "l": "Activation of Rac1 by VAV2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030298", "l": "receptor signaling protein tyrosine kinase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39171", "l": "3-oxoeicosanoyl-CoA + H(+) + NADPH = (3R)-hydroxyeicosanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15657", "l": "1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) = 3-methylcatechol + CO2 + NADH"}, {"i": "EC:1.3.1.68", "l": "\"1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36744", "l": "heptadecasphing-4-enine + tetracosenoyl-CoA => CoA + H(+) + N-tetracosenoyl-heptadecasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296301", "l": "CCRL2 binds CCL19 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48858", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + A + H2O => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56258", "l": "H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-threonyl-[protein] + UDP => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008488", "l": "gamma-glutamyl carboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49654", "l": "H2O + NAD(+) + violaceinate => H(+) + NADH + O2 + protoviolaceinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69140", "l": "RPA binds to the Flap (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426144", "l": "SREBP1A,2 binds the MVD promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12087", "l": "D-mannitol + NAD(+) <=> D-fructose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48290", "l": "CMP + ganglioside GD3 + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51263", "l": "4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] <=> (10bR,4aS)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619843", "l": "ERKs phosphorylate RSKs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629918", "l": "NEIL1 translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038177", "l": "death receptor agonist activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031858", "l": "pituitary adenylate cyclase-activating polypeptide receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10099", "l": "a fatty acyl-[ACP] + S-adenosyl-L-methionine <=> an N-acyl-L-homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "ic": "77.02358060617253", "identifiers": [{"i": "GO:0019842", "l": "vitamin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38093", "l": "beta-tocotrienol + H(+) + S-adenosyl-L-homocysteine => delta-tocotrienol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47345", "l": "3beta-hydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta,26-dihydroxycholest-5-en-7-one + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20013", "l": "carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate"}, {"i": "EC:2.1.3.2", "l": "\"Aspartate carbamoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30920", "l": "A + rhodopin => (3E)-3,4-didehydrorhodopin + AH2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004991", "l": "parathyroid hormone receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1640164", "l": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5195402", "l": "CDK1 phosphorylates LPIN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51878", "l": "desmethylxanthohumol + diphosphate => 2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66873", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 9-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11529", "l": "2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49454", "l": "6-sulfo-D-quinovose + a 1,2-diacyl-sn-glycerol => a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15404", "l": "dolichyl phosphate + UDP-alpha-D-glucose <=> dolichyl beta-D-glucosyl phosphate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797267", "l": "Expression of CD36 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785213", "l": "LIPC dimer binds heparin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21685", "l": "(R)-beta-alanopine + H2O + NAD(+) => beta-alanine + H(+) + NADH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11491", "l": "all-trans-retinol + an acyl-CoA <=> an all-trans-retinyl ester + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6795460", "l": "SGK1 phosphorylates MDM2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58606", "l": "FADH2-C4alpha-hydroperoxide + NAD(+) => FAD + 2 H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661217", "l": "MT1A binds zinc (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928619", "l": "PAK1 binds RAC1:GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451900", "l": "IL2RB binds JAK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65358", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45914", "l": "a 4,5-saturated-(3E)-enoyl-CoA + NADP(+) => a (2E,4E)-dienoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195378", "l": "Homodimerization of VEGF proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35431", "l": "1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside = 4-hydroxy-3-methoxybenzoate + cyanidin 3,7-di-O-beta-D-glucoside"}, {"i": "EC:2.4.1.300", "l": "\"Cyanidin 3-O-glucoside 7-O-glucosyltransferase (acyl-glucose)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052642", "l": "lysophosphatidic acid phosphatase activity"}, {"i": "REACT:R-HSA-8878654", "l": "ACP6 hydrolyses MYS-LPA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37835", "l": "aklavinone + H(+) + NADPH + O2 = epsilon-rhodomycinone + H2O + NADP(+)"}, {"i": "EC:1.14.13.180", "l": "\"Aklavinone 12-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015211", "l": "purine nucleoside transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45259", "l": "hexadecanoate(out) <=> hexadecanoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021520", "l": "NOTCH3 binds WWP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66157", "l": "butanoyl-CoA + tyramine => CoA + H(+) + N-butanoyltyramine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16469", "l": "(R)-2-benzylsuccinate + succinyl-CoA = (R)-2-benzylsuccinyl-CoA + succinate"}, {"i": "EC:2.8.3.15", "l": "\"Succinyl-CoA:(R)-benzylsuccinate CoA-transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9686930", "l": "RIPK3 is cleaved by CASP8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211910", "l": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004737", "l": "pyruvate decarboxylase activity"}, {"i": "MetaCyc:PYRUVATE-DECARBOXYLASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60237", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55274", "l": "11-cis-retinyl tetradecanoate + CoA => 11-cis-retinol + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015098", "l": "molybdate ion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50654", "l": "2-(2-methylsulfanyl)propylmaleate + H2O => 2-(3-methylsulfanyl)propylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54569", "l": "a uridine in rRNA => a pseudouridine in rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448744", "l": "IL20RA binds IL20RB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158942", "l": "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77609", "l": "Binding of APOBEC-1 to form editosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17447", "l": "2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => H2 + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23809", "l": "(S)-scoulerine + S-adenosyl-L-methionine => (S)-tetrahydrocolumbamine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46790", "l": "a 1-[(6Z,9Z,12Z,15Z)-octadectetraenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805981", "l": "HMGB1 release from cells (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047731", "l": "catechol oxidase (dimerizing) activity"}, {"i": "RHEA:12809", "l": "4 catechol + 3 O2 = 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O"}, {"i": "EC:1.1.3.14", "l": "\"Catechol oxidase (dimerizing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5138459", "l": "WNT5A:FZD4 is endocytosed (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1454916", "l": "The ABCC family mediates organic anion transport (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004952", "l": "dopamine neurotransmitter receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38619", "l": "nicotinate beta-D-ribonucleotide + phenol = H(+) + nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside"}, {"i": "EC:2.4.2.55", "l": "\"Nicotinate D-ribonucleotide:phenol phospho-D-ribosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.72", "l": "\"Xylan 1,3-beta-xylosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130706", "l": "MHC class II antigen processing (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050111", "l": "mycocerosate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392263", "l": "AVP(20-28) binds AVPR2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418172", "l": "F2R binds ARRB2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250962", "l": "botG LC cleaves target cell VAMP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804100", "l": "HMGB1 binds LPS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874849", "l": "CREBRF binds CREB3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32095", "l": "acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose = CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H(+)"}, {"i": "EC:2.3.1.197", "l": "\"dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11360", "l": "2 2',3,4,4',6'-pentahydroxychalcone + 2 H(+) + O2 = 2 aureusidin + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70982", "l": "Fumarate + H2O <=> (S)-Malate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71783", "l": "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951486", "l": "CD46 binds C4b (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42485", "l": "D-sorbitol(out) + N(pros)-phospho-L-histidyl-[protein] => D-sorbitol 6-phosphate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428885", "l": "Activation of CLASP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42642", "l": "a menaquinol + H(+) + S-adenosyl-L-homocysteine => a 2-demethylmenaquinol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043794", "l": "formate dehydrogenase (coenzyme F420) activity"}, {"i": "EC:1.2.99.-", "l": "\"With other acceptors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20899", "l": "ATP + hydrogencarbonate + urea <=> ADP + H(+) + phosphate + urea-1-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16822", "l": "6-phospho-D-gluconate + NAD(+) => 6-phospho-2-dehydro-D-gluconate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38326", "l": "2 1-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-glycerol + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11455", "l": "7-deoxyloganin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + loganin + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615638", "l": "EGR2 and SOX10 bind the MBP gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50200", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39194", "l": "(2E)-docosenoyl-CoA + H(+) + NADPH <=> docosanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23401", "l": "7,8-dihydroxykynurenate + O2 => 5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28250", "l": "acetyl-CoA + H(+) + malonyl-CoA = acetoacetyl-CoA + CO2 + CoA"}, {"i": "EC:2.3.1.194", "l": "\"Acetoacetyl-CoA synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420591", "l": "Nectin-2:Nectin 3 trans heterodimer interaction (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21521", "l": "2 [Fe(III)-cytochrome b1] + formate => 2 [Fe(II)-cytochrome b1] + CO2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "56.022554756482101", "identifiers": [{"i": "GO:0022804", "l": "active transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659764", "l": "Defective SLC6A2 does not cotransport NAd, Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40582", "l": "1-O-(1Z)-hexadecenyl-2 (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814088", "l": "SYS1 binds AcM-ARFRP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17315", "l": "AMP + diphosphate + H(+) + L-histidyl-tRNA(His) => ATP + L-histidine + tRNA(His)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32878", "l": "a 1-acyl-sn-glycerol + H2O <=> a fatty acid + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60209", "l": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 => 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2203479", "l": "STAB2 (FEEL-2) binds ligands (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59381", "l": "4-amino-4-deoxyprephenate + NAD(+) => 3-(4-aminophenyl)pyruvate + CO2 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160931", "l": "Disassembly of tight junctions (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22088", "l": "ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate"}, {"i": "EC:2.7.6.5", "l": "\"GTP diphosphokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31848", "l": "(S)-2,3-epoxysqualene => shionone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66433", "l": "H(+)(out) + L-galactose(out) => H(+)(in) + L-galactose(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57652", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 = CMP + ganglioside GM1alpha + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73800", "l": "SAICAR => AICAR + Fumarate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64857", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + phomopsene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417820", "l": "P2Y9 receptor can bind to LPA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10106", "l": "CO2 + gibberellin A1 + succinate => 2-oxoglutarate + gibberellin A20 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17692", "l": "3'-phosphoadenylyl sulfate + glycochenodeoxycholate <=> adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050488", "l": "ecdysteroid UDP-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40852", "l": "FAD + H(+) + pentadecanoyl-CoA => (2E)-pentadecenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0051536", "l": "iron-sulfur cluster binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20143", "l": "2-aminoprop-2-enoate + an S-alkyl sulfenate => an S-alkyl-L-cysteine S-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18853", "l": "NAD(+) + tartrate = 2-hydroxy-3-oxosuccinate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35080", "l": "doxorubicin(in) => doxorubicin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549304", "l": "OCT3 mediates renal clearance of organic cations (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106243", "l": "syn-isopimara-7,15-diene synthase activity"}, {"i": "RHEA:62188", "l": "9alpha-copalyl diphosphate = diphosphate + syn-isopimara-7,15-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.26"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443894", "l": "TXA2 is hydrolysed to TXB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11895", "l": "6-O-methylnorlaudanosoline + S-adenosyl-L-methionine <=> H(+) + nororientaline + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785762", "l": "IL13RA1 binds TYK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75891", "l": "Abortive Initiation After Second Transition (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618328", "l": "ATAT acetylates microtubules (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21328", "l": "cholesterol + O2 = cholest-4-en-3-one + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592240", "l": "Formation of NRF2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60423", "l": "H2O + triglucosyl-enterobactin <=> [N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]3 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.22.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0030275", "l": "LRR domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58310", "l": "25-substituted-cholesteryl beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine => 25-substituted-cholesterol + beta-D-glucosyl-N-(15Z-tetracosenoyl)-sphing-4E-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878117", "l": "RUNX3 binds ZFHX3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34360", "l": "a 1,2-diacylglycerol + H2O => a 2-acylglycerol + a carboxylate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193646", "l": "NGF binding to p75NTR inactivates RHOA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687465", "l": "MRN complex binds RBBP8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009488", "l": "IL34 binds CSF1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399939", "l": "Autophosphorylation of PAK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25377", "l": "2-methyl-branched fatty aldehyde + formyl-CoA => a 2-hydroxy-3-methyl fatty acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103079", "l": "2-(3'-methylthio)propylmalate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23303", "l": "(2E)-geranyl diphosphate + isopentenyl diphosphate <=> (2Z,6E)-farnesyl diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031005", "l": "filamin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29356", "l": "dUMP + H2O => 2'-deoxyuridine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416929", "l": "PTGFR binds PGF2a (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62495", "l": "ATP + holo-[peptidyl-carrier protein] + L-arginine <=> AMP + diphosphate + L-arginyl-[peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928597", "l": "EPH:EFN dimers tetramerise (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60487", "l": "CTP + UTP <=> cyclic CMP-UMP + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191636", "l": "Phosphorylation of Cx43 by c-src (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22265", "l": "3,5,6-trichloropyridin-2-ol + FADH2 + O2 => 3,6-dichloropyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004791", "l": "thioredoxin-disulfide reductase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005459", "l": "UDP-galactose transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40634", "l": "H2O + trioctadecanoylglycerol <=> 2,3-dioctadecanoyl-sn-glycerol + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052843", "l": "inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity"}, {"i": "MetaCyc:RXN-10977"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25858", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (9Z)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9006873", "l": "IL21 receptor STAT binding (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52499", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983147", "l": "Release of E3 from polyubiquitinated substrate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29328", "l": "(S)-malate(in) + succinate(out) => (S)-malate(out) + succinate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66247", "l": "ATP + H(+) + IC-asc-C9 <=> diphosphate + IC-asc-C9-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31613", "l": "H2O + rhodopin => 1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853323", "l": "Activated FGFR3 fusion-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12703", "l": "[thioredoxin]-dithiol + a ribonucleoside 5'-triphosphate => [thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-triphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.117"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.51"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16399", "l": "D-glucose + D-glucose 1,6-bisphosphate => 2 D-glucopyranose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66385", "l": "(2E,6E,10E,14E)-geranylfarnesol => scalar-17(25)-en-19-ol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018702", "l": "1,1-dichloro-2,2-bis(4-chlorophenyl)ethene dehalogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47953", "l": "[prokaryotic ubiquitin-like protein]-C-terminal-L-glutamine + H2O => [prokaryotic ubiquitin-like protein]-C-terminal-L-glutamate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183067", "l": "Localization of CBL:GRB2 to the membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874849", "l": "CREBRF binds CREB3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809764", "l": "SBF1 binds MTMR2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102207", "l": "docosanoate omega-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65885", "l": "2-oxoglutarate + 3-hydroxy-L-kynurenine => H2O + L-glutamate + xanthurenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007615", "l": "E2F6 binds RBBP8 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111879", "l": "PIP2 hydrolysis (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848338", "l": "PNPLA4 hydrolyzes TAG (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27359", "l": "iodomethane + S-adenosyl-L-homocysteine => iodide + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5628871", "l": "BRD7 promotes EP300-mediated acetylation of TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.39", "l": "\"Plasmepsin II\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33694", "l": "2-(1-hydroxyethyl)thiamine diphosphate + 2-oxobutanoate <=> (S)-2-ethyl-2-hydroxy-3-oxobutanoate + thiamine diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37088", "l": "[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine => 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864569", "l": "WWOX binds TFAP2C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617828", "l": "TRIP11:IFT20 dissociates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950732", "l": "Expression of Macrophage migration inhibitory factor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47076", "l": "17beta-hydroxyandrosta-1,4-dien-3-one + H(+) + NADPH = 17beta-hydroxy-5beta-androst-1-en-3-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55874", "l": "2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH => anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62125", "l": "a 2'-deoxyribonucleoside 5'-phosphate + GTP => a 2'-deoxyribonucleoside 5'-diphosphate + GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60472", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) + 5-formyltetrahydrofolate(out) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) + 5-formyltetrahydrofolate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50740", "l": "H2O + leukotriene C4 = glycine + leukotriene F4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41987", "l": "NAD(+) + propan-2-ol <=> acetone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030412", "l": "formimidoyltetrahydrofolate cyclodeaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25378", "l": "a 2-hydroxy-3-methyl fatty acyl-CoA <=> 2-methyl-branched fatty aldehyde + formyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17994", "l": "ATP + beta-alanine + L-gamma-glutamyl-L-cysteine => ADP + gamma-L-glutamyl-L-cysteinyl-beta-alanine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036143", "l": "kringle domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63282", "l": "a 1-acyl-2-(15-hydroperoxy-8Z,11Z,13E-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008667", "l": "2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity"}, {"i": "MetaCyc:DHBDEHYD-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161293", "l": "Tropoelastin forms aggregate globules (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "75.582117822819498", "identifiers": [{"i": "GO:0008047", "l": "enzyme activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863494", "l": "ASICs bind STOML3, (STOM) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51561", "l": "(S)-bulbocapnine + S-adenosyl-L-methionine => (S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64300", "l": "3-phenylpropylamine + pyruvate = 3-phenylpropanal + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047457", "l": "exo-(1,4)-alpha-D-glucan lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-354087", "l": "Recruitment of GRB2 to p-PTK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64237", "l": "atrochrysone carboxyl-[ACP] + H2O => atrochrysone carboxylate + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31428", "l": "(2E,6E)-farnesyl diphosphate => (-)-exo-alpha-bergamotene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48345", "l": "an N-acyl-sphingoid base + UDP-alpha-D-galactose => a D-galactosylceramide + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6799350", "l": "Exocytosis of specific granule membrane proteins (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35123", "l": "H(+)(out) + L-alanyl-D-glutamate(out) = H(+)(in) + L-alanyl-D-glutamate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34127", "l": "(2E)-geranyl diphosphate + olivetolate = cannabigerolate + diphosphate"}, {"i": "EC:2.5.1.102", "l": "\"Geranylpyrophosphate--olivetolic acid geranyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38247", "l": "(9Z)-hexadecenoyl-CoA + hexadecan-1-ol = 1-O-hexadecyl (9Z)-hexadecenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196753", "l": "2xPPCS ligates PPanK with Cys (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212352", "l": "Formation of ARC coactivator complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29981", "l": "2'-deoxyadenosine(out) + H(+)(out) => 2'-deoxyadenosine(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-68611", "l": "Formation of ORC(1-5) complex (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8870466", "l": "RGGT:CHM binds RABs (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57732", "l": "A + all-trans-7,8-dihydroretinol = AH2 + all-trans-retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56981", "l": "4-hydroxybenzyl alcohol + 2 oxidized [azurin] => 4-hydroxybenzaldehyde + 2 H(+) + 2 reduced [azurin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60372", "l": "D-fructose(out) = D-fructose(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16400", "l": "2 D-glucopyranose 1-phosphate <=> D-glucose + D-glucose 1,6-bisphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58535", "l": "15alpha-stemmadenine intermediate I + H2O <=> akuammicine + formate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51162", "l": "5-methylcytidine(60) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(60) in tRNA(Asp) + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874979", "l": "ACBD3 binds GOLGB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0008556", "l": "P-type potassium transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034957", "l": "3-nitrophenol nitroreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48642", "l": "11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH => (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35469", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-(methylsulfanyl)propanoate + H(+) => (6S)-5,6,7,8-tetrahydrofolate + S,S-dimethyl-beta-propiothetin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47930", "l": "(S)-3-sulfolactate + 2 H(+) + NADPH => (S)-3-sulfolactaldehyde + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051010", "l": "microtubule plus-end binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28224", "l": "3-dehydro-L-gulonate 6-phosphate + ADP + H(+) => 3-dehydro-L-gulonate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19105", "l": "4-aminobutanal + H2O + NAD(+) = 4-aminobutanoate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.19", "l": "\"Aminobutyraldehyde dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029453", "l": "Phosphorylation of VAV (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043959", "l": "L-erythro-3-methylmalyl-CoA lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32934", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2-diacyl-sn-glycerol <=> a cardiolipin + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008922", "l": "long-chain fatty acid [acyl-carrier-protein] ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454689", "l": "14-3-3 Binds p-S237-TBC1D1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097158", "l": "pre-mRNA intronic pyrimidine-rich binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11422", "l": "H2O + NADP(+) + senecionine N-oxide => NADPH + O2 + senecionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19055", "l": "H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42198", "l": "(9Z,12Z)-heptadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (9Z)-heptadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.1.8", "l": "\"4-hydroxy-tetrahydrodipicolinate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39329", "l": "(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H2O => (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010309", "l": "acireductone dioxygenase [iron(II)-requiring] activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68611", "l": "Formation of ORC(1-5) complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53087", "l": "[(1->2)-beta-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->2)-beta-D-glucosyl](n+1) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62738", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + diphosphate => 1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2106614", "l": "Duplex miRNA is loaded into Argonaute (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941895", "l": "Formation of CDK4/6:CCND complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434030", "l": "TBK1 is recruited to the Viral dsRNA:TLR3:TICAM1 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "72.96845868813736", "identifiers": [{"i": "GO:0046915", "l": "transition metal ion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66699", "l": "(4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + S-adenosyl-L-methionine <=> (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9670014", "l": "Factor VIIIa dissociates  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730871", "l": "RasGRP interacts with DAG and Ca2+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50460", "l": "a medium chain fatty acid + ATP + holo-[ACP] = a medium-chain fatty acyl-[ACP] + AMP + diphosphate"}, {"i": "EC:6.2.1.47", "l": "\"Medium-chain-fatty-acid--(acyl-carrier-protein) ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852331", "l": "GTSE1 translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16520", "l": "(R)-1-aminopropan-2-ol + NAD(+) <=> aminoacetone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26520", "l": "acryloyl-CoA + H2O => 3-hydroxypropanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-901047", "l": "Binding of ERp57 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28746", "l": "nitrate(in) + nitrite(out) <=> nitrate(out) + nitrite(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174171", "l": "Association of Cyclin A with the APC/C (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57868", "l": "(E)-4-coumaroyl-CoA + 2-oxoglutarate + O2 = (E)-2,4-dihydroxycinnamoyl-CoA + CO2 + succinate"}, {"i": "EC:1.14.11.62", "l": "\"Trans-4-coumaroyl-CoA 2'-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23740", "l": "4-hydroxyphenylacetonitrile + H(+) + NADPH + O2 = 4-hydroxymandelonitrile + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114558", "l": "Thrombin-activated PARs activate Gq (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33743", "l": "an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000213", "l": "tRNA-intron endonuclease activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047644", "l": "alizarin 2-beta-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16786", "l": "an adenosine in tRNA + S-adenosyl-L-methionine => an N(6)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672973", "l": "MAP2Ks phosphorylate MAPKs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44996", "l": "(R)-carnitine + acetoacetyl-CoA = CoA + O-3-oxobutanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50869", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 => (5,12,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047709", "l": "bis(2-ethylhexyl)phthalate esterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74707", "l": "Binding of IRS to insulin receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9609921", "l": "SGTA binds Tail-anchored protein (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51064", "l": "3'-phosphoadenylyl sulfate + lithocholate = adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.23"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62425", "l": "(E)-caffeoyl-CoA + H2O => 3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429449", "l": "Syk activation leads to SLP-76 activation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1297275", "l": "CD9:Izumo Binding (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199935", "l": "MSK1 activates CREB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158795", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9617595", "l": "SGTA binds mislocalized membrane protein (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48171", "l": "H2O + N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine <=> N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40801", "l": "2-methylpropanoate + CoA + H(+) => 2-methylpropanoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52827", "l": "(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 <=> (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17998", "l": "Co-precorrin-2 + S-adenosyl-L-methionine => Co-precorrin-3 + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5226979", "l": "ADD1:ADD2 binds DMTN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25191", "l": "chloride + glycolate + H(+) => chloroacetate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1963589", "l": "ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43366", "l": "beta-D-glucosyl-L-erythro-N-acylsphing-4-enine + H(+) + UDP => L-erythro-N-acylsphing-4-enine + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53176", "l": "H2O + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54379", "l": "(+)-copalyl diphosphate + H2O <=> diphosphate + nezukol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669023", "l": "TWEAK binds FN14 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912734", "l": "CBL:CRKL binds RAPGEF1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72143", "l": "Lariat Formation and 5'-Splice Site Cleavage (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625426", "l": "Retrograde IFT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197958", "l": "FPGS-2 transforms THF to THFPG (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21547", "l": "(2E,6E)-farnesyl diphosphate + ATP <=> (2E,6E)-farnesyl triphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53724", "l": "ATP + N-acetyl-D-glucosamine = ADP + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621002", "l": "HOXB1 activates HOXB2 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32541", "l": "(+)-car-3-ene + diphosphate => (2E)-geranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928588", "l": "EPHBs binds PTK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043807", "l": "3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity"}, {"i": "MetaCyc:1.2.7.7-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0033677", "l": "DNA/RNA helicase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22673", "l": "2 (2E,6E)-farnesyl diphosphate => diphosphate + presqualene diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211247", "l": "Cleavage of DNA by DFF40 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858475", "l": "ppDVL recruits RAC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373705", "l": "Caspase cleavage of DCC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21374", "l": "CO2 + ethanol + NH4(+) => H(+) + H2O + urethane"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666008", "l": "SCAI binds SRF:MKL1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42205", "l": "corticosterone + NAD(+) => 11-dehydrocorticosterone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22640", "l": "NADP(+) + sphinganine = 3-oxosphinganine + H(+) + NADPH"}, {"i": "EC:1.1.1.102", "l": "\"3-dehydrosphinganine reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18990", "l": "H(+) + L-valine => 2-methylpropan-1-amine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50445", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2 => prostaglandin G3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5228992", "l": "ROCK1,ROCK2 are activated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46895", "l": "2-oxoglutarate + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate <=> 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.1", "l": "\"Acylaminoacyl-peptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58592", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693347", "l": "HTR1A binds 5HT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39203", "l": "(2E)-tetracosenoyl-CoA + H(+) + NADPH = NADP(+) + tetracosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047483", "l": "imidazoleacetate-phosphoribosyldiphosphate ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66418", "l": "ADP + glutathione(out) + glycoursodeoxycholate(out) + H(+) + phosphate => ATP + glutathione(in) + glycoursodeoxycholate(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353058", "l": "glucose 6-phosphate + H2O => glucose + phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981621", "l": "Neuroglobin:oxygen dissociates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25431", "l": "ATP + N-acetyl-D-hexosamine <=> ADP + H(+) + N-acetyl-alpha-D-hexosamine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56080", "l": "[Rab1 protein]-L-serine + CDP-choline = [Rab1 protein]-O-phosphocholine-L-serine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46687", "l": "3-oxochol-4-en-24-oyl-CoA + A <=> (22E)-3-oxo-chol-4,22-dien-24-oyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130194", "l": "ABL phosphorylates WAVEs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9645598", "l": "RRAGC,D hydrolyzes GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35330", "l": "eicosanoyl-CoA + H(+) + malonyl-CoA <=> 3-oxodocosanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062182", "l": "all-trans retinoic acid 4-hydrolase activity"}, {"i": "RHEA:51492", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50998", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-homocysteine => L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-917693", "l": "ESCRT Disassembly (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662466", "l": "XYLB phosphorylates D-xylulose (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50955", "l": "7-chloro-L-tryptophan + AH2 + O2 <=> A + CO2 + 2 H2O + monodechloroaminopyrrolnitrin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690152", "l": "USP5 cleaves polyubiquitin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66109", "l": "2-oxobutanoate + L-cysteine => (2S)-2-aminobutanoate + 2-oxo-3-sulfanylpropanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21176", "l": "L-idonate + NADP(+) = 5-dehydro-D-gluconate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159733", "l": "Furin cleaves pro-factor X to factor X (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39596", "l": "(2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H(+) + NADPH => (10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210285", "l": "Trans-homophilic interaction of PECAM-1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61783", "l": "keto-L-tagatose <=> keto-L-sorbose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61950", "l": "CO2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl-[protein] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24518", "l": "CoA + H(+) + N(2')-acetylgentamicin C1a => acetyl-CoA + gentamicin C1a"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58967", "l": "H2O + hexanal + O2 <=> H(+) + H2O2 + hexanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0140065", "l": "peptide butyryltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847537", "l": "RAB43:GTP binds USP8NL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853320", "l": "FGFR2IIIa TM binds ligand and full length receptors to inhibit signaling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56352", "l": "4-hydroxybenzoate + bromide + 2 H(+) + NADPH + O2 = 3-bromo-4-hydroxybenzoate + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429036", "l": "SLC2A9 transports Fru, Glc, urate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34467", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + valerena-4,7(11)-diene"}, {"i": "EC:4.2.3.139", "l": "\"Valerena-4,7(11)-diene synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002134", "l": "UTP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31012", "l": "(S)-2,3-epoxysqualene => camelliol C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30990", "l": "(S)-2,3-epoxysqualene <=> (17Z)-protosta-17(20),24-dien-3beta-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56294", "l": "4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => fenbendazole + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54038", "l": "[mycoredoxin]-S-mycothiol-L-cysteine + arsenite => [mycoredoxin]-L-cysteine + arseno-mycothiol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43707", "l": "ATP + H(+) + tetradecanoate <=> diphosphate + tetradecanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35024", "l": "hydroquinone O-beta-D-glucopyranoside(out) => hydroquinone O-beta-D-glucopyranoside(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42917", "l": "adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733545", "l": "Bile salts and acids bind ALB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55165", "l": "a jasmonyl-L-isoleucinate + H(+) + NADPH + O2 => H2O + L-isoleucine-12-hydroxyjasmonate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53235", "l": "cholesta-5,24-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-25-epoxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29676", "l": "glycerol(in) => glycerol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47294", "l": "4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445704", "l": "Calcium Binds Caldesmon (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200646", "l": "Cytosolic folate export across the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112436", "l": "Formation of Elongin complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29371", "l": "dAMP + H2O = 2'-deoxyadenosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322429", "l": "XIAP monoubiquinates TLE (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32218", "l": "(6R)-NADHX <=> (6S)-NADHX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617972", "l": "FOXO3 binds SOD2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58600", "l": "2 L-ascorbate + N-(9Z-octadecenoyl)glycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-(9Z-octadecenoyl)-(2S)-hydroxyglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35651", "l": "(4R)-hydroxysphinganine + a fatty acyl-CoA = an N-acyl-(4R)-4-hydroxysphinganine + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38125", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50849", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35722", "l": "(3S)-versiconol acetate + H2O <=> (S)-versiconol + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004062", "l": "aryl sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417825", "l": "P2Y11 receptor can bind to ATP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011971", "l": "Estrogen-responsive MYB gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-606287", "l": "RSF complex binds the centromere (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38593", "l": "chloroorienticin B + dTDP + H(+) => devancoaminyl-vancomycin + dTDP-beta-L-4-epi-vancosamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003785", "l": "actin monomer binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050633", "l": "acetyl-CoA C-myristoyltransferase activity"}, {"i": "RHEA:18161", "l": "acetyl-CoA + tetradecanoyl-CoA = 3-oxohexadecanoyl-CoA + CoA"}, {"i": "EC:2.3.1.155", "l": "\"Acetyl-CoA C-myristoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046974", "l": "histone methyltransferase activity (H3-K9 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10592", "l": "a 3',5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a 3'-hydroxy,5'-unsubstituted flavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64351", "l": "2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H(+) <=> deacetylpyripyropene E"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694633", "l": "SARS virus buds into ERGIC lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66106", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-tyrosine => 3-(4-hydroxyphenyl)pyruvate + L-kynurenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4647593", "l": "EP400 binds CDKN1A promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709098", "l": "DHFR dimer reduces FOLA to DHF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46347", "l": "propanoyl-CoA + tetradecanoyl-CoA <=> 3-oxo-2-methylhexadecanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27713", "l": "ATP + guanosine <=> ADP + GMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30448", "l": "3-methylxanthine + H(+) + NADH + O2 => formaldehyde + H2O + NAD(+) + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.52"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209840", "l": "Two DITs combine to form thyroxine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004100", "l": "chitin synthase activity"}, {"i": "MetaCyc:CHITIN-SYNTHASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37730", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48045", "l": "ganglioside GM1 (d18:1(4E)/18:0) + H2O => D-galactose + ganglioside GM2 (d18:1(4E)/18:0)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9028730", "l": "Activated NTRK2 binds FRS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34060", "l": "agroclavine + NADP(+) => didehydroagroclavine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39560", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA => (2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71783", "l": "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10450", "l": "a flavone + CO2 + H2O + succinate => 2-oxoglutarate + a flavanone + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211219", "l": "Translocation of caspase-3 to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706319", "l": "Active FLT3 binds to SLA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9017507", "l": "RHOJ binds effectors at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28236", "l": "(S)-1-pyrroline-5-carboxylate + H(+) + H2O => L-glutamate 5-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050659", "l": "N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50160", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45854", "l": "Co(II)-factor IV + S-adenosyl-L-homocysteine => Co(II)-factor III + H(+) + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937814", "l": "RUNX3 translocates to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34214", "l": "ecgonine methyl ester + NADP(+) <=> ecgonone methyl ester + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22942", "l": "ADP + H(+) + N(omega)-phospho-L-arginine => ATP + L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5251942", "l": "Hikeshi binds HSP70s:ATP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22435", "l": "a (3S)-3-hydroxyacyl-CoA + NAD(+) <=> a 3-oxoacyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59258", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) => Fe(III)-enterobactin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42363", "l": "D-allulose <=> keto-D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41132", "l": "1-decanoyl-sn-glycero-3-phosphocholine + H2O => 1-decanoyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "77.349316285872916", "identifiers": [{"i": "GO:0015154", "l": "disaccharide transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905948", "l": "ABC-type 3',5'-cyclic GMP transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036238", "l": "gallate dioxygenase activity"}, {"i": "RHEA:28927", "l": "3,4,5-trihydroxybenzoate + O2 = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + 2 H(+)"}, {"i": "EC:1.13.11.57", "l": "\"Gallate dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507875", "l": "Aquaporins passively transport urea into cells (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.51", "l": "\"Cruzipain\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43219", "l": "(24S)-hydroxycholesterol + 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine <=> (24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49342", "l": "2-hydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800298", "l": "HGF dimer binds MET (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32125", "l": "citrate(out) + H(+)(out) => citrate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45721", "l": "N-hexadecanoylsphing-4-enine(in) => N-hexadecanoylsphing-4-enine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62028", "l": "H2O + stigmasteryl 3-beta-D-glucoside = D-glucose + stigmasterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592436", "l": "Initial activation of proMMP9 by MMPs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047773", "l": "carnitinamidase activity"}, {"i": "MetaCyc:CARNITINAMIDASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448660", "l": "IL31:IL31RA:JAK1 binds OSMR:JAK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871266", "l": "YAP1 binds TEAD3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25738", "l": "L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38198", "l": "androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25839", "l": "3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O <=> 5-deoxy-D-glucuronate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174171", "l": "Association of Cyclin A with the APC/C (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-434362", "l": "Recruitment Of Cytoplasmic Proteins To Vesicles (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19142", "l": "all-trans-retinol => 11-cis-retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33378", "l": "a 1-acylglycerone 3-phosphate + H(+) + NADPH <=> a 1-acyl-sn-glycero-3-phosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004850", "l": "uridine phosphorylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48479", "l": "ganglioside GT1a (d18:1(4E)) + H2O <=> ganglioside GD1a (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24838", "l": "5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102536", "l": "sakuranetin 6-hydroxylase activity"}, {"i": "MetaCyc:RXN-14754"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164834", "l": "Enzyme-bound ATP is released (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47352", "l": "a hexanoate ester + H2O = an aliphatic alcohol + H(+) + hexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45542", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41849", "l": "(2E)-octenoyl-[ACP] + H(+) + NADPH => NADP(+) + octanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849085", "l": "ARHGAP35 binds RHOA:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2002428", "l": "Removal of fibrillar collagen N-propeptides (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022186", "l": "SLC2A3 gene expression is stimulated by MECP2:CREB1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66170", "l": "[protein]-with a C-terminal TM segment(in) + ADP + H(+) + phosphate => [protein]-with a C-terminal TM segment(out) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693783", "l": "NAALADases hydrolyse NAAG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55202", "l": "2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine => 5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004515", "l": "nicotinate-nucleotide adenylyltransferase activity"}, {"i": "REACT:R-HSA-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418858", "l": "RhoGTPase GEF's recruited to DCC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41153", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-hydroperoxy-10E-octadecenoate + H(+) => 1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43306", "l": "1-(3-O-sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + beta-D-Gal-(1<->1')-Cer"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419841", "l": "Light stimulates opsin receptors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32705", "l": "8-hydroxycopalyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694392", "l": "3a translocates to the ERGIC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13624", "l": "4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose <=> 1-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10578", "l": "CDP-N-methylethanolamine + diphosphate => CTP + H(+) + N-methylethanolamine phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.21"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10042", "l": "AMP + phosphate => adenosine 3',5'-bisphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3782637", "l": "HDAC8 deacetylates histones (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66834", "l": "diphosphate + preasperterpenoid A => (2E,6E,10E,14E)-geranylfarnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625482", "l": "PTK2 binds activated EGFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018766", "l": "RHOU binds effectors at the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0015226", "l": "carnitine transmembrane transporter activity"}, {"i": "REACT:R-HSA-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8957241", "l": "TP73 tetramer translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982768", "l": "GH:GHR:JAK2 complex undergoes a conformational change (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944263", "l": "Association of procollagen type II (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50632", "l": "a 2-(omega-methylsulfanyl)alkylmalate = a 2-(omega-methylsulfanyl)alkylmaleate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2247513", "l": "STAB1:ligand is endocytosed (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212642", "l": "L-Glutamine transport into neurons (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170120", "l": "Translocation of Cdc25B to the cytoplasm (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47113", "l": "chenodeoxycholate + glycine => glycochenodeoxycholate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849857", "l": "KLK5 cleaves and activates CELA2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432121", "l": "LDL binds to LRP8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0022883", "l": "zinc efflux transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63673", "l": "(S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADH => H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23924", "l": "pppGp(2'-5')A = 2',3'-cGAMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30808", "l": "L-pipecolate + NAD(+) => Delta(1)-piperideine-2-carboxylate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021950", "l": "MECP2 binds MEF2C gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418872", "l": "Phosphorylation of FADK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005105", "l": "type 1 fibroblast growth factor receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47887", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46069", "l": "(3E)-nonenoyl-CoA => (2E)-nonenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15789", "l": "L-xylose + NADP(+) = H(+) + L-xylono-1,4-lactone + NADPH"}, {"i": "EC:1.1.1.113", "l": "\"L-xylose 1-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17188", "l": "IMP + NADP(+) + NH4(+) <=> GMP + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.2.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60038", "l": "3-hydroxy-3-methylhexanoate + L-glutamine => H2O + N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341669", "l": "Defective NEU1 does not hydrolyse Neu5Ac from glycoconjugates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51076", "l": "2-hydroxy-17beta-estradiol + 3'-phosphoadenylyl sulfate = 2-hydroxy-17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31158", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) <=> (4S)-4-hydroxy-L-glutamate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36584", "l": "dTDP-alpha-D-fucose + NADP(+) => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174224", "l": "Dissociation of Cdc20 from APC/C complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022881", "l": "protein-N(PI)-phosphohistidine-N-acetylgalactosamine phosphotransferase system transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730856", "l": "Autophosphorylation of PAK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170986", "l": "Ral-GDS binds to Ras-GTP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43229", "l": "L-glutamine(104)-[histone H2A] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutamine(104)-[histone H2A] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32890", "l": "all-trans-beta-carotene + O2 <=> 2 all-trans-retinal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44483", "l": "3,4-dihydroxy-5-all-trans-heptaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-heptaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444171", "l": "Receptor FFAR2 binds carboxylates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24704", "l": "CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose => NAD(+) + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59910", "l": "2 H(+) + hexanoate + NADPH => H2O + hexanal + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102374", "l": "ursolic aldehyde 28-monooxygenase activity"}, {"i": "RHEA:43068", "l": "beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase]"}, {"i": "MetaCyc:RXN-13502"}, {"i": "EC:1.14.14.126", "l": "\"Beta-amyrin 28-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429663", "l": "SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11120", "l": "cyanate + 3 H(+) + hydrogencarbonate = 2 CO2 + NH4(+)"}, {"i": "EC:4.2.1.104", "l": "\"Cyanase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52865", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5432825", "l": "HMGB1 binds TLR4:LY96 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-434989", "l": "SEMA7A binds to PLXNC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33617", "l": "AMP + diphosphate + octadecanoyl-CoA => ATP + CoA + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110307", "l": "REV1 binds AP-dsDNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53154", "l": "H(+) + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16524", "l": "H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> NADH + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29244", "l": "H(+) + menaquinone-8 + NADH => menaquinol-8 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65249", "l": "AH2 + 5 H(+) + 5 malonyl-CoA => 6-hydroxymellein + A + 5 CO2 + 5 CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848314", "l": "IL36:IL1RL2 binds IL1RAP-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.80"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001083", "l": "alpha-D-glucan binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9038052", "l": "GREB1 binds ESR1:ESTG and co-activators (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15567", "l": "a carboxylate + an L-alpha-amino acid => an N-acyl-L-amino acid + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83650", "l": "FasL:Fas binds FADD (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011347", "l": "ROBO3.1 mRNA translation is positively regulated by MSI1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46404", "l": "2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 = (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O"}, {"i": "EC:1.14.19.25", "l": "\"Acyl-lipid omega-3 desaturase (cytochrome b5)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418200", "l": "SRC-1 bound to ARRB2 is not activated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51153", "l": "2 a thiol + L-cysteinyl-[sulfatase] + O2 => 3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29706", "l": "L-valine(in) <=> L-valine(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022894", "l": "Intermediate conductance calcium-activated potassium channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20834", "l": "ADP + guanine(in) + H(+) + phosphate => ATP + guanine(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.4", "l": "\"Nicotine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18300", "l": "a phtalamide + H2O <=> a primary amine + phthalate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070205", "l": "2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44126", "l": "CoA + tetradecanyl hexadecanoate => hexadecanoyl-CoA + tetradecan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5627775", "l": "Autophosphorylation of PAK1,2,3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098603", "l": "selenol Se-methyltransferase activity"}, {"i": "REACT:R-HSA-2408544", "l": "AdoSeMet is converted to AdeSeHCys by MetTrans(1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43431", "l": "1,2-didecanoyl-sn-glycerol + ATP <=> 1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6783880", "l": "PIPOX oxidises PPCA to P6C (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57384", "l": "(13S,14R)-1,13-dihydroxy-N-methylcanadine + acetyl-CoA = (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA"}, {"i": "EC:2.3.1.285", "l": "\"(13S,14R)-1,13-dihydroxy-N-methylcanadine 13-O-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605723", "l": "Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28013", "l": "propanoyl-CoA + succinate <=> propanoate + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58547", "l": "2 L-ascorbate + N-tetradecanoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-tetradecanoyl-(2S)-hydroxyglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694427", "l": "MIA3 binds procollagen VII (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67152", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[NO transferase protein] = L-cysteinyl-[NO transferase protein] + S-nitroso-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-481009", "l": "Exocytosis of platelet dense granule content (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3899291", "l": "SUMOylation of EP300 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29185", "l": "2 H(+) + menaquinone-8 + 2 superoxide => menaquinol-8 + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.28", "l": "\"Bacillolysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5671993", "l": "CIT-3 binds DLG4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36230", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52052", "l": "9-hexadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204824", "l": "Interaction of Tie2 and Ang4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39567", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61877", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-8-hydroperoxy-20-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863914", "l": "Transport of SEC22B, TAP and PLC from ER to ERGIC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22712", "l": "adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate"}, {"i": "EC:2.7.7.62", "l": "\"Adenosylcobinamide-phosphate guanylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70592", "l": "PXLP-K259-GOT1 dimer deaminates L-Asp (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682769", "l": "LGI2 binds ADAM22,23 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66703", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + ATP + CoA <=> (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430347", "l": "MigFilin associates with Filamin and F-actin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944236", "l": "Association of procollagen type XIV (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33779", "l": "6-kestotriose + sucrose = 6,6-kestotetraose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047030", "l": "4-hydroxycyclohexanecarboxylate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31560", "l": "L-galactose + NAD(+) => H(+) + L-galactono-1,4-lactone + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63217", "l": "7-cyano-7-carbaguanosine(15) in tRNA + L-lysine => 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45068", "l": "(R)-carnitine + an acyl-CoA = CoA + O-acyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10177", "l": "(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+) => (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691004", "l": "XPC binds RAD23 and CETN2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57514", "l": "(1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+) => chlorobenzene + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112430", "l": "Formation of P-TEFb complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-744231", "l": "SLC35D2 exchanges UDP-sugars for UMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29673", "l": "Ca(2+)(out) => Ca(2+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29466", "l": "K(+)(in) <=> K(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682388", "l": "Autophagosome maturation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1222491", "l": "Lactoferrin scavenges iron ions (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29457", "l": "D-serine(out) => D-serine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803230", "l": "Dissociation of moderate activity BRAF complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68637", "l": "CDC6 protein is synthesized under the control of E2F transcription factors (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52398", "l": "CO2 + dihydroxyacetone phosphate + NADH => 4-O-phospho-D-threonate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15758", "l": "L-homoserine + NAD(+) => H(+) + L-aspartate 4-semialdehyde + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33907", "l": "4-(methylamino)butanoate + H2O + O2 = 4-aminobutanoate + formaldehyde + H2O2"}, {"i": "EC:1.5.3.19", "l": "\"4-methylaminobutanoate oxidase (formaldehyde-forming)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015568", "l": "L-idonate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033718", "l": "pyranose dehydrogenase (acceptor) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60711", "l": "(1R,3R)-chrysanthemal + H2O + NAD(+) <=> (1R,3R)-chrysanthemate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140082", "l": "SUMO-ubiquitin ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37162", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10022", "l": "(S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH => H2O + L-saccharopine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448963", "l": "Interaction of MyoD:E protein with MEF2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5692779", "l": "p-S182 MAPKAPK5 phosphorylates FOXO1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0098599", "l": "palmitoyl hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22688", "l": "D-alanine + H2O + O2 = H2O2 + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799097", "l": "ATM phosphorylates ZNF420 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004500", "l": "dopamine beta-monooxygenase activity"}, {"i": "RHEA:19117", "l": "dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical"}, {"i": "EC:1.14.17.1", "l": "\"Dopamine beta-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46307", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5660666", "l": "CBP and p300 binds NF-kB complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191790", "l": "Loading and methylation of Sm proteins onto SMN Complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59799", "l": "dodecanoyl-CoA + L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] <=> CoA + H(+) + N(6)-dodecanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66993", "l": "3-methylpentanoate + ATP + CoA => 3-methylpentanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58020", "l": "6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) = eupatolide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51894", "l": "acetate + cadaverine => H2O + N-acetylcadaverine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404144", "l": "Parenchymal atROL translocates to HSCs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18544", "l": "10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine <=> dihydrochelirubine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20969", "l": "L-arabinonate => 2-dehydro-3-deoxy-L-arabinonate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59561", "l": "H2O + N,N',N''-triacetylchitotriono-1,5-lactone => H(+) + N,N',N''-triacetylchitotrionate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33281", "l": "(E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011975", "l": "Estrogen-responsive MYC gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31538", "l": "2-oxoglutarate + L-arginine + O2 <=> (S)-1-pyrroline-5-carboxylate + CO2 + guanidine + H(+) + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53045", "l": "a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine => a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645672", "l": "p14ARF translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13183", "l": "ADP + H(+) + nitrate(in) + phosphate => ATP + H2O + nitrate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.n5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8941701", "l": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74718", "l": "Internalisation of the insulin receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433488", "l": "Phosphorylation of SHP2 by SFKs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51798", "l": "colupulone + diphosphate + H(+) => deoxycohumulone + dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451347", "l": "Activation of JNK by DSCAM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38751", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27528", "l": "(2E,6E)-farnesol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497883", "l": "Ferrous iron reduces the BH3 radical back to BH4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50302", "l": "all-trans-4-hydroxyretinol + H2O + 2 oxidized [adrenodoxin] => all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607753", "l": "CARD9 oligomerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35324", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) => (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981926", "l": "RAC1 and CDC42 activate PAK3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964773", "l": "OXGR1 binds 2OG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19760", "l": "(3R)-3-hydroxy-L-aspartate <=> NH4(+) + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50105", "l": "taurine + tetradecanoyl-CoA => CoA + H(+) + N-tetradecanoyl-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16869", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}, {"i": "EC:1.13.11.33", "l": "\"Arachidonate 15-lipoxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69127", "l": "Formation of the Flap Intermediate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211950", "l": "CYP24A1 24-hydroxylates CTL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54361", "l": "4-methyl-2-oxopentanoate + H(+) => 3-methylbutanal + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14510", "l": "2-oxoglutarate + mugineate + O2 => 3-epihydroxymugineate + CO2 + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49182", "l": "a bacteriochlorophyllide c + H(+) + S-adenosyl-L-homocysteine => a bacteriochlorophyllide d + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159733", "l": "Furin cleaves pro-factor X to factor X (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64032", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38201", "l": "19-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199062", "l": "KLRC1:KLRD1 heterodimer interacts with HLA-E (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626220", "l": "C2CD3 binds the mother centriole (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008915", "l": "lipid-A-disaccharide synthase activity"}, {"i": "RHEA:22668", "l": "2-N,3-O-bis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = H(+) + lipid A disaccharide (E. coli) + UDP"}, {"i": "EC:2.4.1.182", "l": "\"Lipid-A-disaccharide synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56791", "l": "apo-[corrinoid adenosyltransferase] + cob(II)alamin <=> cob(II)alamin--[corrinoid adenosyltransferase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11292", "l": "2 H(+) + O2 + rifamycin B = H2O2 + rifamycin O"}, {"i": "EC:1.10.3.6", "l": "\"Rifamycin-B oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39092", "l": "(2E)-decenedioyl-CoA + H2O => (3S)-hydroxydecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61504", "l": "pelargonidin + UDP-alpha-D-glucose = pelargonidin 3-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9630923", "l": "NFkB inhibitor binds NFkB complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38451", "l": "hydrogen sulfide + NADP(+) + n sulfur = NADPH + (n+1) sulfur"}, {"i": "EC:1.8.1.19", "l": "\"Sulfide dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50594", "l": "15-oxoprostaglandin F1alpha + H(+) + NADPH => 13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382054", "l": "PDGF binds to extracellular matrix proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804741", "l": "MDM2 forms homo- or heterodimers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36626", "l": "3-phenylpyruvate + S-adenosyl-L-methionine <=> (3S)-2-oxo-3-phenylbutanoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17504", "l": "H2O + polyneuridine aldehyde <=> 16-epivellosimine + CO2 + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16678", "l": "fluoroacetaldehyde + H2O + NAD(+) => fluoroacetate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786050", "l": "IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032798", "l": "DOCK3 activates RAC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373075", "l": "Metabotropic glutamate receptors bind glutamate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035877", "l": "death effector domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53524", "l": "1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205289", "l": "Autophosphorylation of KIT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49158", "l": "dTDP-alpha-D-forosamine + H(+) + S-adenosyl-L-homocysteine => dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29567", "l": "2 chloride(in) + H(+)(out) = 2 chloride(out) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49613", "l": "(R)-2-hydroxyglutarate + NAD(+) => 2-oxoglutarate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27545", "l": "methanol + N,N-dimethyl-4-nitrosoaniline <=> 4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24309", "l": "25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062046", "l": "dehydropipecolic acid reductase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-434650", "l": "MATEs mediate extrusion of xenobiotics (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41345", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => (5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134904", "l": "Phosphorylation of beta-catenin at Ser552 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17494", "l": "A + glycerol => AH2 + dihydroxyacetone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50566", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10774", "l": "D-glucose + D-glucose 6-phosphate => 6-phospho-beta-D-glucosyl-(1->4)-D-glucose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57566", "l": "7-deoxyloganetic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-cis-trans-nepetalactol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109702", "l": "PDPK1 phosphorylates AKT2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57038", "l": "(1->3)-alpha-D-glucosyl-[(1->6)-alpha-D-glucosyl]n + D-fructose => [(1->6)-alpha-D-glucosyl](n) + sucrose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814096", "l": "ARL1:GTP binds SCOC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5620975", "l": "MLKL binds PIPs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63042", "l": "H(+) + lovastatin carboxylate => H2O + lovastatin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22783", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (13S)-hydroperoxy-(9Z,11E)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004349", "l": "glutamate 5-kinase activity"}, {"i": "KEGG.REACTION:R00239"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210773", "l": "PDX1-dependent synthesis of NR5A2 protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40360", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + ATP => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949343", "l": "ITGAL gene,(ITGA4 gene) expression is stimulated by RUNX3:CBFB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000901", "l": "translation repressor activity, non-nucleic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870558", "l": "CDK5:p25 phosphorylates FOXO3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62301", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + H(+) + NADPH => 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419334", "l": "Melatonin receptors can bind melatonin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.195", "l": "\"L-ornithine N(5)-monooxygenase (NADPH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17017", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA"}, {"i": "RHEA:33151", "l": "(R)-dihydrolipoamide + acetyl-CoA = (R)-S(6)-acetyldihydrolipoamide + CoA"}, {"i": "EC:2.3.1.12", "l": "\"Dihydrolipoyllysine-residue acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191299", "l": "Squalene is oxidized to its epoxide (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24684", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH => 5,10-methylenetetrahydromethanopterin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165179", "l": "Formation of TSC1:TSC2 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63226", "l": "2-[12-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl]-glycerol => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13329", "l": "A + a 3-oxosteroid = a 3-oxo-Delta(1)-steroid + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22121", "l": "CoA + GTP + succinate => GDP + phosphate + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38509", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16372", "l": "(R)-lactate + NAD(+) <=> H(+) + NADH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848751", "l": "PTK6 binds AKT1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25160", "l": "2-oxoglutarate + L-ornithine = L-glutamate + L-glutamate 5-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47861", "l": "ganglioside GT1b (d18:1(4E)) + H2O => ganglioside GD1b (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507869", "l": "Aquaporins passively transport glycerol into cells (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202702", "l": "CD177 binds PECAM-1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54160", "l": "2-oxoglutarate + [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + O2 = [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14008", "l": "H2O + L,L-cystathionine <=> 2-oxobutanoate + L-cysteine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45696", "l": "N-(acetyl)-sphing-4-enine-1-phosphate(in) = N-(acetyl)-sphing-4-enine-1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391158", "l": "SIRP alpha binds CD47 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13267", "l": "1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine => 1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-984689", "l": "Kinesin-7 is a dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21096", "l": "3-dehydroquinate = 3-dehydroshikimate + H2O"}, {"i": "EC:4.2.1.10", "l": "\"3-dehydroquinate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.344", "l": "\"dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD(P)(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683679", "l": "Ubiquination of protein E (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57691", "l": "apo-[corrinoid adenosyltransferase] + cob(II)inamide <=> cob(II)inamide--[corrinoid adenosyltransferase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008470", "l": "isovaleryl-CoA dehydrogenase activity"}, {"i": "REACT:R-HSA-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53319", "l": "GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38778", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69152", "l": "Removal of remaining Flap (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10642", "l": "cis,cis-muconate + H(+) => muconolactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65456", "l": "2-methylbutan-1-ol + acetyl-CoA = 2-methylbutyl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086062", "l": "voltage-gated sodium channel activity involved in Purkinje myocyte action potential"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29292", "l": "(25S)-3-oxocholest-4-en-26-oate + ATP + CoA => (25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22542", "l": "9-riburonosyladenine + H(+) + H2O2 => 5'-dehydroadenosine + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14736", "l": "Ag(+)(in) + ATP + H2O <=> ADP + Ag(+)(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390402", "l": "Movement of O-hexadecylglycerone phosphate from the peroxisomal matrix to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009905", "l": "ent-copalyl diphosphate synthase activity"}, {"i": "MetaCyc:5.5.1.13-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12659", "l": "a (2R)-2-methylacyl-CoA => a (2S)-2-methylacyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51721", "l": "ATP(in) + CoA(in) + H(+)(out) + octadecanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + octadecanoyl-CoA(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-453342", "l": "PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44003", "l": "2-oxoglutarate + 3-methylhexadecanoyl-CoA + O2 <=> 2-hydroxy-3-methylhexadecanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429101", "l": "HMIT co-transports myo-inositol with a proton (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59005", "l": "dodecanal + H2O + O2 => dodecanoate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66427", "l": "ATP + H2O + leukotriene B4(in) <=> ADP + H(+) + leukotriene B4(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11060", "l": "ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)"}, {"i": "EC:6.1.1.5", "l": "\"Isoleucine--tRNA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53959", "l": "gamma-L-glutamyl-[BtrI ACP] + H(+) <=> 4-aminobutanoyl-[BtrI ACP] + CO2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004838", "l": "L-tyrosine:2-oxoglutarate aminotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49032", "l": "(-)-4'-desmethyl-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] = 4'-demethylepipodophyllotoxin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.132", "l": "\"(-)-4'-demethyl-deoxypodophyllotoxin 4-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66133", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350901", "l": "Iodide is organified (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196964", "l": "RFK:Mg2+ phosphorylates RIB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14909", "l": "L-gulonate + NADP(+) = aldehydo-D-glucuronate + H(+) + NADPH"}, {"i": "EC:1.1.1.19", "l": "\"Glucuronate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11074", "l": "catechol + CO2 + NADP(+) + NH4(+) => anthranilate + 3 H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57524", "l": "a 5'-triphospho-guanosine-ribonucleotide-tRNA(His) + H2O = a 5'-phospho-guanosine-ribonucleotide-tRNA(His) + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62213", "l": "3-hydroxybenzyl alcohol + O2 + reduced [NADPH--hemoprotein reductase] => gentisyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59304", "l": "3'-phosphoadenylyl sulfate + firefly L-luciferin = adenosine 3',5'-bisphosphate + firefly L-sulfoluciferin + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853496", "l": "SCF:FBXL7 binds AURKA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211962", "l": "CYP4F11 16-hydroxylates 3OH-PALM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40863", "l": "FAD + H(+) + heptadecanoyl-CoA = FADH2 + trans-2-heptadecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27741", "l": "2'-deoxyguanosine + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + guanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52392", "l": "ATP + D-erythronate = 4-phospho-D-erythronate + ADP + H(+)"}, {"i": "EC:2.7.1.220", "l": "\"D-erythronate 4-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53669", "l": "(2E,6E)-farnesyl diphosphate => (1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35599", "l": "NADP(+) + propane-1,3-diol = 3-hydroxypropanal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44509", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58982", "l": "3,7-dimethylocta-2,6-dienoate + H(+) + H2O2 => citral + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607734", "l": "PKC-delta translocates to plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43566", "l": "[5-(aminomethyl)-3-furyl]methyl phosphate + pyruvate => 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64088", "l": "acetyl-CoA + 9 H(+) + holo-[ACP] + 9 malonyl-CoA = 3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 9 CO2 + 10 CoA + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28877", "l": "H(+)(out) + L-tyrosine(out) => H(+)(in) + L-tyrosine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43759", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62021", "l": "H2O + sitosteryl 3-beta-D-glucoside => (24R)-ethylcholest-5-en-3beta-ol + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0035591", "l": "signaling adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194809", "l": "botD LC cleaves target cell VAMP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.2", "l": "\"NAD(P)H dehydrogenase (quinone)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26115", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + epi-cedrol"}, {"i": "EC:4.2.3.39", "l": "\"Epi-cedrol synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0030250", "l": "guanylate cyclase activator activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052627", "l": "vanillate amino acid synthetase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15781", "l": "L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate"}, {"i": "EC:5.4.3.6", "l": "\"Tyrosine 2,3-aminomutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035662", "l": "Toll-like receptor 4 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425861", "l": "Activation of Protein Kinase C novel isoforms (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102656", "l": "1-18:2-2-trans-16:1-phosphatidylglycerol desaturase activity"}, {"i": "MetaCyc:RXN-1727"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047473", "l": "D-alanine [D-alanyl carrier protein] ligase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070524", "l": "11-beta-hydroxysteroid dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26565", "l": "2-succinylbenzoyl-CoA + H(+) <=> 1,4-dihydroxy-2-naphthoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46189", "l": "an aliphatic nitrile + 2 H2O => a carboxylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14806", "l": "ATP + D-allose => ADP + D-allose 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870469", "l": "RGGT geranylgeranylates RAB proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193656", "l": "p75NTR interacts with RIP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57266", "l": "GDP + glycolate + H(+) => H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44523", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380316", "l": "Association of NuMA with microtubules (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57985", "l": "(20S)-ginsenoside Rg3 + UDP-alpha-D-glucose => (20S)-ginsenoside Rd + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373024", "l": "isocitrate + NAD+ => 2-oxoglutarate (alpha-ketoglutarate) + CO2 + NADH + H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36827", "l": "dioscin + 3 H2O = D-glucose + diosgenin + 2 L-rhamnopyranose"}, {"i": "EC:3.2.1.189", "l": "\"Dioscin glycosidase (diosgenin-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16160", "l": "2 [Fe(III)-leghemoglobin] + NADPH <=> 2 [Fe(II)-leghemoglobin] + H(+) + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35914", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10543", "l": "7,8-dihydroneopterin <=> 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6804100", "l": "HMGB1 binds LPS (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47420", "l": "A + glutaryl-CoA = (2E)-glutaconyl-CoA + AH2"}, {"i": "EC:1.3.99.32", "l": "\"Glutaryl-CoA dehydrogenase (acceptor)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45753", "l": "(3E)-decenoyl-CoA => (2E)-decenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13714", "l": "a ubiquinone + succinate => a ubiquinol + fumarate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050440", "l": "2-methylcitrate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62519", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-galactosamine <=> H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11963", "l": "2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate <=> (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372359", "l": "pyruvate + H+ [cytosol] => pyruvate + H+ [mitochondrial matrix] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36155", "l": "AH2 + Co(II)-factor III + S-adenosyl-L-methionine = A + Co-precorrin-4 + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.272", "l": "\"Cobalt-factor III methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-168947", "l": "Ligand binds to TLR10 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374896", "l": "Uptake of Noradrenaline (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.19"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008266", "l": "poly(U) RNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22731", "l": "H(+) + L-seryl-tRNA(Sec) + selenophosphate <=> L-selenocysteinyl-tRNA(Sec) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18601", "l": "3,4-dihydroxyphthalate + H(+) = 3,4-dihydroxybenzoate + CO2"}, {"i": "EC:4.1.1.69", "l": "\"3,4-dihydroxyphthalate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012556", "l": "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110171", "l": "MBD4 glycosylase mediated recognition and binding of an uracil opposite to a guanine at CpG sequences (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66080", "l": "2-oxopentanoate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminopentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008480", "l": "sarcosine dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046568", "l": "3-methylbutanol:NAD(P) oxidoreductase activity"}, {"i": "MetaCyc:1.1.1.265-RXN"}, {"i": "EC:1.1.1.265", "l": "\"3-methylbutanal reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045148", "l": "tripeptide aminopeptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42720", "l": "S-adenosyl-L-methionine + uridine(2552) in 23S rRNA = 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.166", "l": "\"23S rRNA (uridine(2552)-2'-O)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624133", "l": "ARL3:GTP binds the UNC119B complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39402", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA <=> (2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3095889", "l": "MMACHC reduces Cbl (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022065", "l": "DSPGs are secreted (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17095", "l": "1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170978", "l": "p-FRS2:CRKL binds C3G (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047444", "l": "N-acylneuraminate-9-phosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37182", "l": "(9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate <=> (6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046180", "l": "KSPG is secreted from the cell (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23511", "l": "(7R)-7-(4-carboxybutanamido)cephalosporanate + H2O <=> (7R)-7-aminocephalosporanate + glutarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3262512", "l": "G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75856", "l": "Abortive Initiation Before Second Transition (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19124", "l": "an S-substituted glutathione(in) + ATP + H2O <=> ADP + an S-substituted glutathione(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0045703", "l": "ketoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15207", "l": "an oligosaccharide-(1->4)-N-acetyl-beta-D-glucosamine-(1->4)-N-acetyl-alpha-D-glucosamine 1-phosphate + dolichyl phosphate + 2 H(+) => a dolichyl diphosphooligosaccharide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62651", "l": "(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 <=> (5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15579", "l": "D-ribose + uracil => H2O + uridine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63827", "l": "2 3-(4-hydroxyphenyl)pyruvate <=> aspulvinone E + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50093", "l": "a fatty acyl-CoA + taurine => an N-fatty acyl-taurine + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49280", "l": "FADH2 + O2 + phenol = catechol + FAD + H(+) + H2O"}, {"i": "EC:1.14.14.20", "l": "\"Phenol 2-monooxygenase (FADH(2))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10867", "l": "3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2 <=> 2-(acetamidomethylene)succinate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050577", "l": "GDP-L-fucose synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419426", "l": "Cannabinoid receptors can bind cannabinoids (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018421", "l": "UDP-N-acetylglucosamine:serine-protein N-acetylglucosamine-1-phosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975170", "l": "IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174224", "l": "Dissociation of Cdc20 from APC/C complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849463", "l": "PTK6 phosphorylates SFPQ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13938", "l": "4-sulfobenzoate + NADH + O2 => 3,4-dihydroxybenzoate + NAD(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483142", "l": "PC is transphosphatidylated to PG by PLD1-4/6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33030", "l": "4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spheroidene <=> 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + spheroiden-2-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114552", "l": "Thrombin-activated PARs activate G12/13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177922", "l": "EGFR dimerization (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49003", "l": "aurachin C + H(+) + NADH + O2 <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694721", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44860", "l": "(R)-carnitine + 4,8-dimethylnonanoyl-CoA = CoA + O-4,8-dimethylnonanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60651", "l": "an N-(acyl)-sphingosylphosphoethanolamine <=> an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24722", "l": "H(+) + L-methionyl(44)-[F-actin] + NADPH + O2 = H2O + L-methionyl(44)-(R)-S-oxide-[F-actin] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265301", "l": "Corticotropin cleavage from POMC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24033", "l": "sucrose => 6-O-alpha-D-glucopyranosyl-D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57014", "l": "a menaquinol + sulfate => a menaquinone + H2O + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34074", "l": "trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20287", "l": "alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine => beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66423", "l": "ATP + glutathione(in) + H2O + tauroursodeoxycholate(in) <=> ADP + glutathione(out) + H(+) + phosphate + tauroursodeoxycholate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57950", "l": "3-methylcatechol + H2O + NAD(+) => 2-hydroxytoluene + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11736", "l": "2-exo-hydroxy-1,8-cineole + NAD(+) = 6-oxocineole + H(+) + NADH"}, {"i": "EC:1.1.1.241", "l": "\"6-endo-hydroxycineole dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111883", "l": "Hydrolysis of phosphatidylcholine (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654651", "l": "Activated FGFR4 binds FRS3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.n1"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004731", "l": "purine-nucleoside phosphorylase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008831", "l": "dTDP-4-dehydrorhamnose reductase activity"}, {"i": "RHEA:21796", "l": "dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH"}, {"i": "EC:1.1.1.133", "l": "\"dTDP-4-dehydrorhamnose reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-179410", "l": "Association of Nek2A with MCC:APC/C (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938913", "l": "RUNX1 binds ELF1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60063", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876484", "l": "NPC2 transfers CHOL to NPC1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603791", "l": "PEX16:PEX19:PEX3 dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18315", "l": "benzaldehyde + hydrogen cyanide => (R)-mandelonitrile"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140761", "l": "sequestered tissue factor -> tissue factor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950423", "l": "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12902", "l": "D-arginine + H2O => D-ornithine + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.2.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64942", "l": "dGMP + H(+) + phosphate => dGDP + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042881", "l": "D-galactonate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534378", "l": "Hv1 Mediated H+ Permeability (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30446", "l": "2 glycyl-tRNA(Gly) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc <=> 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39029", "l": "a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382054", "l": "PDGF binds to extracellular matrix proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624800", "l": "CDK1 phosphorylates LBR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28492", "l": "H(+)(out) + K(+)(out) => H(+)(in) + K(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950456", "l": "IL12B dimerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20558", "l": "2 H(+) + H2O + urea => CO2 + 2 NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950782", "l": "p-STAT1 binds p-STAT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65684", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontadienoyl)-sphing-4-enine = a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontadienoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3791155", "l": "Laminin-322 degradation by MMP14 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29682", "l": "formate(in) <=> formate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10437", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8957389", "l": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49995", "l": "H(+) + NADH + O2 + propane <=> H2O + NAD(+) + propan-2-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12301", "l": "S-adenosyl-L-methionine + uridine(47) in tRNA(Phe) => 3-[(3S)-3-amino-3-carboxypropyl]uridine(47) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24895", "l": "5-hydroxyxanthotoxin + S-adenosyl-L-methionine => isopimpinellin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52637", "l": "2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2 => a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685605", "l": "SLAMF7 binds SLAMF7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17334", "l": "O-acetyl-L-serine + zeatin => acetate + H(+) + L-lupinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40559", "l": "dTDP-beta-L-evernosamine + NADPH + O2 = dTDP-N-hydroxy-beta-L-evernosamine + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669906", "l": "Ligand-independent dimerization of KIT juxtamembrane domain mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44009", "l": "2-methyl-branched fatty aldehyde + H2O + NAD(+) => 2-methyl fatty acid + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "70.906311464949411", "identifiers": [{"i": "GO:0051119", "l": "sugar transmembrane transporter activity"}, {"i": "REACT:R-HSA-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64101", "l": "2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + TAN-1612"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36855", "l": "an N-acetyl-L-cysteine-S-conjugate + H2O = acetate + an S-substituted L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64112", "l": "an N-acyl-L-phenylalanine + H2O = a fatty acid + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.20"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.14"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21891", "l": "NADP(+) + OPC-8 <=> (10Z,15Z)-12-oxophytodienoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373717", "l": "DCC interacts with DIP13alpha (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9693198", "l": "RHOD binds effectors at the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70692", "l": "ornithine => putrescine + CO2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879298", "l": "acetylglucosamine is transferred from UDP-GlcNAc onto inositol-1-phosphate (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35522", "l": "(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl) ethanolamine + H2O <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36414", "l": "cholesta-5,7-dien-3beta-ol + hnu <=> calciol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39080", "l": "(3S)-hydroxydodecanedioyl-CoA + NAD(+) => 3-oxododecanedioyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13860", "l": "dolichyl beta-D-glucosyl phosphate + H2O <=> D-glucose + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701548", "l": "PRDM1 gene expression downstream of ALK signaling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61666", "l": "(2E,6E,10E)-geranylgeranyl phosphate + ADP + H(+) => (2E,6E,10E)-geranylgeraniol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798373", "l": "MDM2 ubiquitinates DYRK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24789", "l": "(2E,4Z)-2-hydroxy-6-oxononadienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977605", "l": "Factor H displaces Bb (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59942", "l": "2-methyloctadecanoate + CoA + H(+) => 2-methyloctadecanoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49493", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate => 2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + 2-oxoglutarate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65904", "l": "3-hydroxy-L-kynurenine + glyoxylate = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.27", "l": "\"Cathepsin S\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174121", "l": "Association of Securin with Cdc20:APC/C complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30923", "l": "(R)-glycerate + ADP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+)"}, {"i": "EC:2.4.1.268", "l": "\"Glucosylglycerate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684169", "l": "G6B binds PTPN6,PTPN11 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8866277", "l": "AP-2 directly binds some endocytic cargo (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65207", "l": "(3R)-3-hydroxybutanoyl-CoA + H2O <=> (R)-3-hydroxybutanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.12", "l": "\"Peptidyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166753", "l": "Conversion of C4 into C4a and C4b (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670673", "l": "FIX is secreted (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61378", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H(+) + phosphate => 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420688", "l": "GABAB heterodimeric receptor binds GABA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33890", "l": "(-)-secoisolariciresinol + 2 NAD(+) <=> (-)-matairesinol + 2 H(+) + 2 NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004910", "l": "interleukin-1, type II, blocking receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43462", "l": "4-hydroxy-6-undecylpyran-2-one + 2 CO2 + 3 CoA => dodecanoyl-CoA + 2 H(+) + 2 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30787", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (6R)-L-erythro-6,7-dihydrobiopterin + H2O + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45931", "l": "15-hydroxypentadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(16-hydroxy-2-oxohexadecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029268", "l": "Phosphorylation and activation of PLCG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940100", "l": "CDK1 phosphorylates VCPIP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43030", "l": "2-aminoprop-2-enoate + H(+) + sulfite => L-cysteate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093332", "l": "p-EPHB phosphorylates SDC2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.7", "l": "\"DNA ligase (ATP, ADP or GTP)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43388", "l": "1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51621", "l": "CTP + formate + H(+) => CO2 + dCTP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629004", "l": "Transport of MCP:pPR-AP:pAP Complex into the Nucleous (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66825", "l": "2 ATP + 2 cob(II)inamide + 2 H2O + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)inamide + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23695", "l": "(R)-malate <=> H2O + maleate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853745", "l": "RET binds GFRA1,GFRA3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-622310", "l": "Activated NOD1 oligomerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112510", "l": "IL6ST is tyrosine phosphorylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2314678", "l": "Aspirin acetylates PTGS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4341073", "l": "PIAS3 SUMOylates PGR with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730858", "l": "Autophosphorylation of BTK/ITK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990838", "l": "poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26086", "l": "(4S)-limonene + H(+) + NADPH + O2 => H2O + limonene 1,2-epoxide + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000247", "l": "C-8 sterol isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52064", "l": "13-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 13-hydroxy-octadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53169", "l": "H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55981", "l": "a 1,2-saturated acyl-CoA + an acyl-CoA + H2O => an (R)-2-alkyl-3-oxoalkanoate + 2 CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24503", "l": "adenosine 5'-tetraphosphate + H2O <=> ATP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39537", "l": "(2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49259", "l": "2-amino-2-deoxy-D-gluconate(out) + N(pros)-phospho-L-histidyl-[protein] <=> 2-amino-2-deoxy-D-gluconate 6-phosphate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29504", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + patchoulol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47833", "l": "ganglioside GD1a + H2O => ganglioside GM1 + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42997", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (R)-cembrene A + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64841", "l": "2-phenylethanol + benzoyl-CoA => CoA + phenethyl benzoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62063", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose <=> alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32709", "l": "(2R,4S)-bornyl diphosphate => (2E)-geranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682826", "l": "LGI1 binds ADAM11 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19269", "l": "2-furoate + ATP + CoA = 2-furoyl-CoA + AMP + diphosphate"}, {"i": "EC:6.2.1.31", "l": "\"2-furoate--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22675", "l": "2 (2E,6E)-farnesyl diphosphate <=> diphosphate + presqualene diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64340", "l": "(2E,6E)-farnesyl diphosphate + 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one = 4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071950", "l": "FADH2 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373732", "l": "Nephrin trans-homophilic interaction (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48516", "l": "1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = dodecanoate + dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15838", "l": "L-glutamate + methylamine => N-methyl-L-glutamate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043428", "l": "2-heptaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24945", "l": "4-hydroxy-L-glutamate + H(+) + NADPH => 1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64560", "l": "butan-2-ol + NAD(+) = butan-2-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42606", "l": "(9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+) => 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63530", "l": "[thioredoxin]-disulfide + 2 H2O => [thioredoxin]-dithiol + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18295", "l": "AMP + diphosphate + oxalyl-CoA => ATP + CoA + oxalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202722", "l": "CD48 binds CD244 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42505", "l": "2-oxoglutarate + N(6)-acetyl-L-lysine => 6-acetamido-2-oxohexanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27357", "l": "iodide + S-adenosyl-L-methionine = iodomethane + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55872", "l": "anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH"}, {"i": "EC:1.7.1.17", "l": "\"FMN-dependent NADH-azoreductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30887", "l": "4-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin = 7,8-dihydropteroate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102251", "l": "all-trans-beta-apo-10'-carotenal cleavage oxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678544", "l": "IL17RA:IL17RE binds IL17C dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114560", "l": "Adhesion of integrin alphaIIbbeta3 to fibrin network (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362465", "l": "GHBP binds GHR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804266", "l": "CHEK2 phosphorylates TTC5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446870", "l": "Polyubiquitinated TRAF6 binds the TAK1 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50901", "l": "10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O => (10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55802", "l": "2 [Fe(III)-cytochrome b5] + 2 H2O + N-acyleicosasphing-4-enine => 2 [Fe(II)-cytochrome b5] + 2 H(+) + N-acyleicosasphinganine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52882", "l": "16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP => 16beta,17beta-estriol + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17924", "l": "D-arabinitol + NAD(+) <=> D-xylulose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006850", "l": "IL21 receptor JAK phosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41699", "l": "1-O-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421472", "l": "2 delta-aminolevulinate => porphobilinogen + 2 H2O (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64312", "l": "2 chloride + 2 FADH2 + 2 O2 + sulochrin = dihydrogeodin + 2 FAD + H(+) + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32975", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + 2 H2O = 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44983", "l": "(R)-carnitine + butanoyl-CoA <=> CoA + O-butanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050563", "l": "trans-feruloyl-CoA synthase activity"}, {"i": "RHEA:19389", "l": "(E)-ferulate + ATP + CoA = (E)-feruloyl-CoA + ADP + phosphate"}, {"i": "RHEA:36251", "l": "(E)-ferulate + ATP + CoA = (E)-feruloyl-CoA + AMP + diphosphate"}, {"i": "EC:6.2.1.34", "l": "\"Trans-feruloyl-CoA synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357432", "l": "AXL binds SRC-1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50565", "l": "acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191636", "l": "Phosphorylation of Cx43 by c-src (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41501", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371467", "l": "SIRT1 deacetylates HSF1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10992", "l": "glycolate + NADP(+) = glyoxylate + H(+) + NADPH"}, {"i": "EC:1.1.1.79", "l": "\"Glyoxylate reductase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17828", "l": "ATP + D-glucose <=> ADP + D-glucose 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12983", "l": "glutathione + 2 H(+) + sulfite => H2O + O2 + S-sulfanylglutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25269", "l": "(R)-noradrenaline + S-adenosyl-L-methionine = (R)-adrenaline + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202328", "l": "Translocation of PKC theta to plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46949", "l": "GTP + S-adenosyl-L-methionine => N(7)-methyl-GTP + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46287", "l": "2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 <=> (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35346", "l": "3-hydroxydocosanoyl-CoA + NADP(+) <=> 3-oxodocosanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912391", "l": "NICD1 is phosphorylated by CDK8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000122", "l": "CD320 transports extracellular TCII:Cbl to endosome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65187", "l": "2-oxoglutarate + O2 + preaustinoid A1 <=> berkeleyone B + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52351", "l": "(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate <=> (24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160851", "l": "HAS1,2,3 mediate the polymerisation of HA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52927", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2168038", "l": "Collagen type XV restin release (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20859", "l": "an N-acylsphing-4-enine + H2O <=> a fatty acid + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046558", "l": "arabinan endo-1,5-alpha-L-arabinosidase activity"}, {"i": "MetaCyc:3.2.1.99-RXN"}, {"i": "EC:3.2.1.99", "l": "\"Arabinan endo-1,5-alpha-L-arabinosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.224", "l": "\"Acetyl-CoA-benzylalcohol acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13716", "l": "a ubiquinone + succinate <=> a ubiquinol + fumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.6", "l": "\"Pyroglutamyl-peptidase II\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209925", "l": "DIT and MIT combine to form triiodothyronine (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-74723", "l": "Endosome acidification (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938251", "l": "CSF2 (GM-CSF) gene expression is stimulated by RUNX1 and CREBBP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33972", "l": "5''-phosphoribostamycin + H2O => phosphate + ribostamycin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13971", "l": "(RNA)-3'-(2',3'-cyclophosphooxy)-ribonucleotide + diphosphate + GMP => (RNA)-3'-(3'-phosphooxy-ribonucleotide) + GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62165", "l": "beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + H2O => D-glucosamine + N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981621", "l": "C3 convertases spontaneously dissociate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56164", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3-phosphocholine = (9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0031956", "l": "medium-chain fatty acid-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27563", "l": "(2E)-geranyl diphosphate + 7 isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + 7 diphosphate"}, {"i": "EC:2.5.1.84", "l": "\"All-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022073", "l": "Procollagen triple helix formation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30381", "l": "(+)-beta-chamigrene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45964", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 H2O = 2 AMP + ATP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12099", "l": "H2O + N-benzylformamide <=> benzylamine + formate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811479", "l": "ING2 recruits EP300 to TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30883", "l": "D-glucurono-3,6-lactone + 2 H2O + NAD(+) = D-glucarate + 3 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684801", "l": "p-Y7-CLEC1B dimer:PDPN binds SYK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31664", "l": "2-oxoglutarate + UDP-N-acetylbacillosamine => L-glutamate + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57034", "l": "CO2 + formate + methylamine + succinate semialdehyde => (E)-2-((N-methylformamido) methylene)succinate + H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64808", "l": "acetyl-CoA + O-(2-aminoethyl)-L-serine = CoA + H(+) + O-(2-acetamidoethyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62182", "l": "diphosphate + viteagnusin D => H2O + peregrinol diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0070122", "l": "isopeptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39861", "l": "a triacyl-sn-glycerol + glycerol => 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047660", "l": "amidinoaspartase activity"}, {"i": "RHEA:14849", "l": "H2O + N-amidino-L-aspartate = L-aspartate + urea"}, {"i": "EC:3.5.3.14", "l": "\"Amidinoaspartase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102006", "l": "4-methyl-2-oxopentanoate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66663", "l": "ATP + beta-D-glucosylceramide(in) + H2O <=> ADP + beta-D-glucosylceramide(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31861", "l": "glutinol => (S)-2,3-epoxysqualene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53417", "l": "8-amino-8-demethylriboflavin + S-adenosyl-L-methionine => 8-demethyl-8-(methylamino)riboflavin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800490", "l": "ATM phosphorylates PIDD1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199154", "l": "CD200 binds to CD200R (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19691", "l": "(S)-lactaldehyde + dihydroxyacetone phosphate => L-rhamnulose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49427", "l": "ATP + validone <=> ADP + H(+) + validone 7-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42026", "l": "3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH => 3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1471322", "l": "Beta-defensins are secreted (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051778", "l": "ent-7-alpha-hydroxykaurenoate oxidase activity"}, {"i": "RHEA:22904", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] = gibberellin A12 aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "MetaCyc:RXN1F-160"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186780", "l": "PI3-kinase binds to the active receptor (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68610", "l": "Formation of ORC(2-5) complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44767", "l": "2-methoxy-6-all-trans-decaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52120", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68637", "l": "CDC6 protein is synthesized under the control of E2F transcription factors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686524", "l": "PP6-PPP6R3 dephosphorylates TERF2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30852", "l": "beta-D-fructose 1-phosphate => D-glyceraldehyde + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73806", "l": "AIR + CO2 => CAIR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9617595", "l": "SGTA binds mislocalized membrane protein (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186778", "l": "SHP2 binds to the active receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050130", "l": "N-methyl-2-oxoglutaramate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9615249", "l": "ARBs bind AGRT1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23212", "l": "H2O + N-acetyl-beta-alanine = acetate + beta-alanine"}, {"i": "EC:3.5.1.21", "l": "\"N-acetyl-beta-alanine deacetylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11561", "l": "(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+) => catechol + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004587", "l": "ornithine-oxo-acid transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093332", "l": "p-EPHB phosphorylates SDC2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24433", "l": "H2O + oxaloacetate => acetate + H(+) + oxalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755479", "l": "SUMOylation of NFKB2 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5228508", "l": "RANBP2 SUMOylates PML with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102924", "l": "gibberellin A44,2-oxoglutarate:oxygen oxidoreductase activity"}, {"i": "MetaCyc:RXN-886"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6804099", "l": "HMGB1 binds LTP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665726", "l": "ERBB2 binds pertuzumab (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59328", "l": "D-xylono-1,5-lactone + H2O = D-xylonate + H(+)"}, {"i": "EC:3.1.1.110", "l": "\"Xylono-1,5-lactonase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43536", "l": "2 D-glyceraldehyde 3-phosphate = 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate"}, {"i": "EC:4.2.3.153", "l": "\"(5-formylfuran-3-yl)methyl phosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59751", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] <=> CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9670673", "l": "FIX is secreted (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669859", "l": "Imatinib-resistant KIT mutants do not bind imatinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46339", "l": "3-oxochola-4,17-dien-22-oyl-CoA + H2O <=> 17-hydroxy-3-oxochol-4-en-22-oyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65856", "l": "A + a 1-hydroxy-3-oxo steroid = a steroid 1,3-dione + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56583", "l": "6-thioguanine + S-adenosyl-L-methionine <=> 6-methylthioguanine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27322", "l": "3-epi-6-deoxocathasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6-deoxotyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372843", "l": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41313", "l": "1-O-methyl (5Z,8Z,10E,12R,14Z)-hydroperoxyiecosatetraenoate => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15558", "l": "ATP + H2O + Ni(2+)(out) => ADP + H(+) + Ni(2+)(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626981", "l": "TNF-alpha:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683836", "l": "SFTPC gene produces pro-SFTPC protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12876", "l": "(R)-2-hydroxy-4-methylpentanoate + NADP(+) <=> 4-methyl-2-oxopentanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53283", "l": "D-threose <=> D-erythrulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11556", "l": "(S)-carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH"}, {"i": "EC:1.1.1.254", "l": "\"(S)-carnitine 3-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64426", "l": "H(+)(in) + L-leucyl-L-proline(in) => H(+)(out) + L-leucyl-L-proline(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12919", "l": "D-glucose + strictosidine aglycone => 3alpha(S)-strictosidine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016154", "l": "pyrimidine-nucleoside phosphorylase activity"}, {"i": "MetaCyc:PYRIMIDINE-NUCLEOSIDE-PHOSPHORYLASE-RXN"}, {"i": "EC:2.4.2.2", "l": "\"Pyrimidine-nucleoside phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21524", "l": "3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)"}, {"i": "EC:2.3.3.13", "l": "\"2-isopropylmalate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40900", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162840", "l": "Reorientation of glucosaminyl-acyl-PI in the endoplasmic reticulum membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58974", "l": "4-hydroxy-3-methoxybenzoate + H(+) + H2O2 => H2O + O2 + vanillin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45709", "l": "3-dehydrocarnitine + acetyl-CoA => 3-dehydrocarnityl-CoA + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52265", "l": "3-(aminomethyl)indole + 2 S-adenosyl-L-methionine => gramine + 2 H(+) + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296421", "l": "NLRP3 oligomerizes via NACHT domains (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183052", "l": "CBL binds to GRB2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665315", "l": "ERBB2 T733I does not bind tesevatinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0031806", "l": "G protein-coupled histamine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373715", "l": "DCC interaction with ROBO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37111", "l": "(15Z)-tetracosenoyl-CoA + sphing-4-enine = CoA + H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867041", "l": "EGFR phosphorylates EPS15 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72185", "l": "mRNA polyadenylation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507870", "l": "Aquaporins passively transport water out of cells (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665871", "l": "ADRM1 binds 26S proteasome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10021", "l": "H2O + L-saccharopine + NADP(+) => (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199404", "l": "CD40L binds CD40 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1299318", "l": "Activation of TASK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849085", "l": "ARHGAP35 binds RHOA:GTP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48841", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0010853", "l": "cyclase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9749197", "l": "ORC1 binds to H4K20me2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199404", "l": "CD40L binds CD40 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63077", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA => 2-acetylphloroglucinol + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46209", "l": "ATP + CoA + eicosanoate => AMP + diphosphate + eicosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35749", "l": "7-epizingiberene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17963", "l": "H2O + leukotriene A4 => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038164", "l": "thrombopoietin receptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047186", "l": "N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419011", "l": "Transhomodimerization of Nectins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.56"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38004", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H(+) + homogentisate => 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5246478", "l": "APOM binds retinoids (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16890", "l": "2-oxoglutarate + 6-acetamido-3-aminohexanoate => 6-acetamido-3-oxohexanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071859", "l": "neuropeptide F receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57819", "l": "dGMP + H2O <=> 2-deoxy-D-ribose 5-phosphate + guanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43370", "l": "4-hydroxy-6-(2-oxotridecyl)pyran-2-one + 3 CO2 + 4 CoA => dodecanoyl-CoA + 3 H(+) + 3 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201639", "l": "Caspase-mediated cleavage of GAS2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351207", "l": "Spermine  => N-acetylated spermine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25306", "l": "7,8-dihydroneopterin + phosphate = 7,8-dihydroneopterin 3'-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668597", "l": "DNA polymerase:primase binds G-strand of the telomere (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45923", "l": "16-hydroxyhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218815", "l": "p-6Y-VEGFR2 binds NCK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56123", "l": "2-all-trans-heptaprenylphenol + H(+) + NADPH + O2 <=> 3-(all-trans-heptaprenyl)benzene-1,2-diol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48237", "l": "2 2-acetylphloroglucinol => 1,3,5-trihydroxybenzene + 2,4-diacetylphloroglucinol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.22", "l": "\"Succinyl-CoA--L-malate CoA-transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60833", "l": "a 5'-end triphospho-guanosine in mRNA + H2O => a 5'-end diphospho-guanosine in mRNA + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848829", "l": "CBL autoubiquitinates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018451", "l": "epoxide dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32757", "l": "apigenin + CO2 + H(+) + H2O + succinate => (2S)-naringenin + 2-oxoglutarate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-217255", "l": "FMO1:FAD N-oxidises TAM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809254", "l": "MTMR8 binds MTMR9 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604834", "l": "SIRT6 binds to acetylated histones at NOTCH1 and NOTCH4 gene promoters (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694433", "l": "MIA2 binds PREB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76060", "l": "RNA Polymerase III Promoter Opening at Type 1 Promoters (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236939", "l": "Interaction of exogenous soluble antigen with its corresponding receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11025", "l": "ATP + NH4(+) => ADP + 2 H(+) + phosphoramidate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50274", "l": "resolvin E1 => (5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57924", "l": "H2O + mutildienyl diphosphate = diphosphate + premutilin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031788", "l": "motilin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54629", "l": "2-oxoglutarate + dodecanoyl-CoA + O2 => 2-hydroxydodecanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614271", "l": "Autocleavage of ADGRG6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25170", "l": "6-oxohexanoate + H(+) => 6-hydroxyhexan-6-olide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353313", "l": "Removal of 3'-phosphoglycolate (PG) moiety from DSB ends (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26563", "l": "2-succinylbenzoyl-CoA + H(+) => 1,4-dihydroxy-2-naphthoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160935", "l": "SMURF1 ubiquitinates RHOA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53022", "l": "a 2-oxocarboxylate + a plastoquinol + NH4(+) => a plastoquinone + an L-alpha-amino acid + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31354", "l": "lupan-3beta,20-diol <=> (S)-2,3-epoxysqualene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35540", "l": "cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2 => albonoursin + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24520", "l": "H2O + L-saccharopine + NAD(+) = (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH"}, {"i": "EC:1.5.1.9", "l": "\"Saccharopine dehydrogenase (NAD(+), L-glutamate-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65482", "l": "CoA + hexyl 2-methylbutanoate => 2-methylbutanoyl-CoA + hexan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35281", "l": "3-oxooctadecanoyl-CoA + CoA => acetyl-CoA + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717193", "l": "GNB1,3:GNG13 binds PLCB2:Ca2+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.n2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853915", "l": "VENTX binds the TP53 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52318", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+) => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853801", "l": "PSPN binds RET:GFRA4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60745", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-pyrethrolone => CoA + pyrethrin I"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11278", "l": "4 benzosemiquinone + 2 H2O => 4 hydroquinone + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43681", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102973", "l": "norsolorinate anthrone synthase activity"}, {"i": "RHEA:35179", "l": "6 H(+) + hexanoyl-[ACP] + 7 malonyl-CoA = 7 CO2 + 7 CoA + 2 H2O + holo-[ACP] + noranthrone"}, {"i": "EC:2.3.1.221", "l": "\"Noranthrone synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987223", "l": "IL10RB binds TYK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658496", "l": "SIAH1:UBE2L6:Ubiquitin binds SNCA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047491", "l": "poly(alpha-L-guluronate) lyase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102325", "l": "2,2',3-trihydroxybiphenyl monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102547", "l": "glucosylglycerate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29623", "l": "alpha-maltopentaose + beta-maltose = alpha-maltohexaose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848939", "l": "PTK6 binds KHDRBS1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061821", "l": "telomeric D-loop binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665767", "l": "Activated FMNL3 binds G-actin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64191", "l": "an N-(fatty acyl)-L-tyrosine + H2O <=> a fatty acid + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22303", "l": "a flavonol + UDP-alpha-D-glucose <=> a flavonol 3-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55534", "l": "2-phenylacetaldehyde + CO2 + H2O2 + NH4(+) => H(+) + H2O + L-phenylalanine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50013", "l": "H(+) + NADPH + O2 + tert-butanol => 2-methylpropane-1,2-diol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14871", "l": "acetate + an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative => an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47974", "l": "dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O => dTDP-4-dehydro-6-deoxy-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39191", "l": "(2E)-docosenoyl-CoA + H(+) + NADPH = docosanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40114", "l": "butanoyl-CoA + H2O <=> butanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35655", "l": "2 ATP = 3',3'-c-di-AMP + 2 diphosphate"}, {"i": "EC:2.7.7.85", "l": "\"Diadenylate cyclase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48036", "l": "globoside Gb4Cer (d18:1(4E)) + H2O = globoside Gb3Cer (d18:1(4E)) + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20726", "l": "a (3E)-enoyl-CoA + H2O => a 4-saturated-(3S)-3-hydroxyacyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34877", "l": "3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH => 2-oxepin-2(3H)-ylideneacetyl-CoA + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27387", "l": "maleate + NH4(+) => H2O + maleamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15535", "l": "3-sulfopyruvate + H(+) + NADH => (R)-3-sulfolactate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433506", "l": "Phosphorylation of APS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391941", "l": "BLT receptors can bind LTB4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044197", "l": "Rel homology domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856808", "l": "Recruitment of AP-2 complex and clathrin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10418", "l": "2-benzylsuccinate => fumarate + toluene"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102041", "l": "7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23624", "l": "a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647632", "l": "CASP3 cleaves GSDME (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41001", "l": "1-tetradecanoyl-sn-glycerol + H(+) + phosphocholine => 1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12985", "l": "GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]"}, {"i": "EC:2.4.1.68", "l": "\"Glycoprotein 6-alpha-L-fucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37830", "l": "(S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 <=> 2,4-dichlorophenol + CO2 + pyruvate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204850", "l": "Interaction of Tie2 and Dok-2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426153", "l": "SREBP1A,1C binds the ACACB promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25700", "l": "(E)-9-(methylsulfanyl)nonanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-hexahomomethionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27367", "l": "bromomethane + S-adenosyl-L-homocysteine => bromide + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42453", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate => H2O + kynurenate"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0030984", "l": "kininogen binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196017", "l": "Dynamin is recruited to the gap junction plaque (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31610", "l": "rhodopin <=> all-trans-lycopene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033727", "l": "aldehyde dehydrogenase (FAD-independent) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798748", "l": "Exocytosis of secretory granule lumen proteins (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60802", "l": "CO2 + gibberellin A44 + succinate => 2-oxoglutarate + gibberellin A53 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209302", "l": "Phosphorylated BSK kinase dissociates from CKA scaffolding protein (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687435", "l": "Enhanced autophagosome formation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41561", "l": "(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FADH2 + O2 => (3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FAD + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48365", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose => beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61776", "l": "rebaudioside D + UDP-alpha-D-glucose = H(+) + rebaudioside M + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48512", "l": "ATP + H2O + phosphinate(out) = ADP + H(+) + phosphate + phosphinate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17973", "l": "diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211924", "l": "CYP4B1 12-hydroxylates ARA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50059", "l": "ATP + glycocholate(in) + H2O <=> ADP + glycocholate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46899", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) <=> a 1,2-diacyl-sn-glycerol + lipid A hexaacyl 1-(2-aminoethyl diphosphate)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000900", "l": "translation repressor activity, mRNA regulatory element binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24511", "l": "NADP(+) + prostaglandin F2alpha <=> H(+) + NADPH + prostaglandin E2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43417", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53066", "l": "2-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 2-methoxyestrone + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013158", "l": "CDC42 GDIs block activation of CDC42 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59175", "l": "hexadecanoyl-AMP + holo-[(hydroxy)phthioceranic acid synthase] <=> AMP + H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34890", "l": "selenate(in) <=> selenate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867613", "l": "PICALM binds R-SNAREs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009922", "l": "fatty acid elongase activity"}, {"i": "REACT:R-HSA-548830", "l": "ELOVL1,4 elongate TCS-CoA and Mal-CoA to 3OHC-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53586", "l": "7-oxoresolvin D2 + H(+) + NADH => NAD(+) + resolvin D2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31046", "l": "(S)-methylmalonate semialdehyde + H2O + NAD(+) <=> 2 H(+) + methylmalonate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5580292", "l": "Defective CYP11B1 does not oxidise 11DCORT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41970", "l": "a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E))"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5620975", "l": "MLKL binds PIPs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618093", "l": "ATP hydrolysis by HSP90 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061632", "l": "RNA lariat debranching enzyme activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49137", "l": "H(+) + L-methionyl-[protein] + NADPH + O2 => H2O + L-methionyl-S-oxide-[protein] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20128", "l": "H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12666", "l": "a 2-deoxystreptamine antibiotic + acetyl-CoA => an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13222", "l": "(R)-mevalonate + NAD(+) => H(+) + mevaldate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44136", "l": "dodecanoyl-CoA + hexadecan-1-ol = CoA + hexadecanyl dodecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16901", "l": "acetyl-CoA + L-2,4-diaminobutanoate = (2S)-4-acetamido-2-aminobutanoate + CoA + H(+)"}, {"i": "EC:2.3.1.178", "l": "\"Diaminobutyrate acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27856", "l": "3-geranyl-4-hydroxybenzoate + diphosphate => (2E)-geranyl diphosphate + 4-hydroxybenzoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49615", "l": "(R)-2-hydroxyglutarate + NAD(+) <=> 2-oxoglutarate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052594", "l": "aminoacetone:oxygen oxidoreductase(deaminating) activity"}, {"i": "MetaCyc:AMACETOXID-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31260", "l": "but-3-ynal + H2O + NAD(+) => 3-butynoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51585", "l": "gamma-butyrobetainyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => crotonobetainyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32124", "l": "citrate(in) + H(+)(in) => citrate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66440", "l": "butan-2-one + NADP(+) = but-3-en-2-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174121", "l": "Association of Securin with Cdc20:APC/C complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216282", "l": "Ubiquitinated CI is degraded by the proteasome complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64369", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 A => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53373", "l": "5,6-dihydrouridine(17) in tRNA + NAD(+) => H(+) + NADH + uridine(17) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4332359", "l": "Active calmodulin binds CAMK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2581488", "l": "SAG binds p-MII to form p-MII:SAG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40433", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19684", "l": "ATP + biotin + CoA <=> AMP + biotinyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396395", "l": "HSPG2 (perlecan) binds alpha-dystroglycan (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003912", "l": "DNA nucleotidylexotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30935", "l": "H2O + nicotinate beta-D-ribonucleotide = beta-D-ribosylnicotinate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44170", "l": "dodecanal + H2O + NAD(+) => dodecanoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689544", "l": "UCHL5 binds INO80 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218806", "l": "FYN autophosphorylates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51197", "l": "chloride(out) + Na(+)(out) + serotonin(out) => chloride(in) + Na(+)(in) + serotonin(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047861", "l": "diiodotyrosine transaminase activity"}, {"i": "MetaCyc:DIIODOTYROSINE-AMINOTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473184", "l": "Follistatin (FST) binds Activin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798743", "l": "Exocytosis of secretory granule membrane proteins (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685531", "l": "SARS virus buds into ERGIC lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103061", "l": "trans-methoxy-C60-meroacyl-AMP ligase activity"}, {"i": "MetaCyc:RXN1G-4141"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41400", "l": "1-hexanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexanoyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49782", "l": "CoA + H(+) + N-docosanoylglycine => docosanoyl-CoA + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3341294", "l": "Superoxide reduces cytochrome c (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209061", "l": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34286", "l": "2 L-tyrosine + O2 <=> 2 L-dopa"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43892", "l": "[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine"}, {"i": "EC:2.8.1.7", "l": "\"Cysteine desulfurase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64140", "l": "an N-(fatty acyl)-L-asparagine + H2O = a fatty acid + L-asparagine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3858482", "l": "DVL is recruited to the receptor (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250280", "l": "ROS oxidize thioredoxin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953013", "l": "E2F7 binds E2F8 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65131", "l": "1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2301205", "l": "SETD8 monomethylates histone H4 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28269", "l": "(2E,6E)-farnesyl diphosphate <=> (S)-beta-bisabolene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9688456", "l": "MLKL binds FLOT1, FLOT2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32950", "l": "a 2-acylglycerol + an acyl-CoA <=> a 1,2-diacyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983421", "l": "Journey of cargo through Golgi complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13507", "l": "betaine aldehyde + H2O2 => choline + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44500", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58364", "l": "a medium-chain primary fatty alcohol + NADP(+) = a medium-chain fatty aldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694428", "l": "LMAN family proteins bind glycosylated cargo (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202727", "l": "Integrin alphaMbeta2 (MAC1) binds JAM3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55610", "l": "a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64339", "l": "H(+) + 2 malonyl-CoA + nicotinyl-CoA <=> 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390835", "l": "DRD1,5 bind DA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21326", "l": "H2O2 + oxidized [rubredoxin] => 2 H(+) + reduced [rubredoxin] + superoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62248", "l": "chloroacetaldehyde + H2O + NADP(+) = chloroacetate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0140410", "l": "solute:bicarbonate symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30846", "l": "H2O + N-formylmaleamate <=> formate + H(+) + maleamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689972", "l": "USP2 deubiquitinates MDM2,MDM4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866851", "l": "CFTR transits to the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613023", "l": "NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683925", "l": "ULK1 is dephosphorylated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16116", "l": "2 cob(II)alamin--[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+) <=> 2 apo--[cyanocobalamin reductase] + 2 cyanocob(III)alamin + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68688", "l": "CDC6 association with ORC:origin complexes mediated by MCM8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30186", "l": "L-galactonate + NAD(+) <=> H(+) + keto-D-tagaturonate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39874", "l": "3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42979", "l": "L-tryptophan <=> 2-aminoprop-2-enoate + indole"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19531", "l": "H(+) + isovitexin 2''-O-beta-D-glucoside + UDP => isovitexin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45471", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa-cis-undecaprenyl diphosphate <=> (Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14974", "l": "L-aspartate => D-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810376", "l": "ING2 binds PI5P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046180", "l": "KSPG is secreted from the cell (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014456", "l": "GDIs block activation of RHOG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801109", "l": "CHM binds RGGT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45518", "l": "(2R,3E)-phycocyanobilin + apo-[phycoerythrocyanin beta-subunit]-Cys(155) => [phycoerythrocyanin beta-subunit]-Cys(155)-phycocyanobilin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809663", "l": "Formation of hair keratin fibres (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30734", "l": "butanoyl-CoA + FAD + H(+) <=> (2E)-butenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58149", "l": "ethyl acetate + H2O => acetate + ethanol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5683792", "l": "p-T68-CHEK2 autophosphorylates (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982792", "l": "Growth hormone receptor binds JAK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62641", "l": "[mycoredoxin]-L-dithiol + a hydroperoxide => [mycoredoxin]-L-disulfide + an alcohol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42101", "l": "ATP + carbamoyl phosphate + H2O + kanamycin A => 6''-O-carbamoylkanamycin A + AMP + diphosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44270", "l": "4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA => 3 H(+) + hexadecanoyl-CoA + 3 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49449", "l": "beta-D-Manp-(1->2)-beta-D-Manp-(1->2)-D-Manp + H2O => alpha-D-mannopyranose + beta-D-mannopyranosyl-(1->2)-D-mannopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2203479", "l": "STAB2 (FEEL-2) binds ligands (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20575", "l": "calcitriol + H2O + 2 oxidized [adrenodoxin] => calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49578", "l": "(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine => AH2 + GTP + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50558", "l": "H2O + prostaglandin J2 => prostaglandin D2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193981", "l": "CYP21A2 oxidises 17HPROG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130619", "l": "TGN-lysosomal vesicle coat assembly (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39394", "l": "(2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH <=> (17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204873", "l": "Interaction of Tie2 and Shp2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624951", "l": "TNPO1 binds KIF17 dimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50766", "l": "4-methylamino-4-dedimethylamino-anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine => 4-amino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23609", "l": "H(+) + H2O + N-isopropylammelide => cyanurate + isopropylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166015", "l": "Association of LBP with LPS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13394", "l": "diphosphate + nicotinate beta-D-ribonucleotide => 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140376", "l": "innate immune receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45165", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O => 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210292", "l": "Interaction of DAP12 and TREM1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48438", "l": "an aliphatic alcohol + H(+) + pentanoate => H2O + pentanoate ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17352", "l": "(2E)-geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole <=> 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20439", "l": "2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH => 5D-5-O-methyl-chiro-inositol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047933", "l": "glucose-1,6-bisphosphate synthase activity"}, {"i": "REACT:R-HSA-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909724", "l": "Recruitment of IFNAR1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54247", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49874", "l": "(+)-dehydrodiconiferyl acid carboxylate + a quinol + H(+) => (+)-dehydrodiconiferyl acid ketone + a quinone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37650", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55761", "l": "a fatty acyl-[ACP] + a lyso-ornithine lipid => an N(2)-[(3R)-3-(acyloxy)acyl]-L-ornithine lipid + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53610", "l": "(2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + H(+) => 4-hydroxyestrone + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961888", "l": "E2F1 binds the CCNA1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44124", "l": "hexadecanoyl-CoA + tetradecan-1-ol = CoA + tetradecanyl hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75850", "l": "Addition of the third nucleotide on the nascent transcript (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56242", "l": "2-octanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl octanoate + apo--[retinol-binding protein] => 1,2-dioctanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034417", "l": "bisphosphoglycerate 3-phosphatase activity"}, {"i": "MetaCyc:RXN-11102"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17026", "l": "NADP(+) + xylitol => H(+) + L-xylulose + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60510", "l": "an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine => a guanosine in mRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12076", "l": "an aromatic primary alcohol + NAD(+) = an aromatic aldehyde + H(+) + NADH"}, {"i": "EC:1.1.1.90", "l": "\"Aryl-alcohol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013435", "l": "RHOD auto-activates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001860", "l": "complement component C3d receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8847534", "l": "RAB43 hydrolyses GTP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983153", "l": "E1 mediated ubiquitin activation (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3965450", "l": "DAAM1 recruits PFN1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65537", "l": "1,3,7-trimethylurate + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + theacrine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389463", "l": "Proteinase-activated receptors can bind thrombin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41587", "l": "dimethylallyl diphosphate + L-tyrosine <=> 4-O-dimethylallyl-L-tyrosine + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018777", "l": "1,3,4,6-tetrachloro-1,4-cyclohexadiene halidohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199154", "l": "CD200 binds to CD200R (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47711", "l": "ADP + alpha-D-glucose 1-phosphate + H(+) <=> ADP-alpha-D-glucose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684801", "l": "p-Y7-CLEC1B dimer:PDPN binds SYK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43492", "l": "7(1)-hydroxychlorophyll a + NADP(+) = chlorophyll b + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15856", "l": "17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(+) <=> 17alpha-hydroxyprogesterone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186798", "l": "GAP binds to PDGF-beta receptors only (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62228", "l": "(E)-ascladiol + A = AH2 + patulin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686578", "l": "Activated ATM phosphorylates ABL1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035538", "l": "carbohydrate response element binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429157", "l": "ABCC4 accumulation of dense granule contents (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482775", "l": "Release of (inferred) platelet cytosolic components (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41143", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702613", "l": "ponatinib-resistant FLT3 mutants don't bind ponatinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.22.1.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64479", "l": "4-[(2E,7S,8E,10E,13R,14R,16E,18E)-14-ethyl-7,13-dihydroxy-2,16,18-trimethylicosa-2,8,10,16,18-pentaenoyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate <=> 4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17414", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => an N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42964", "l": "uridine(54/55) in tRNA = pseudouridine(54/55) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45981", "l": "3-oxochol-4-en-22-oyl-CoA + H(+) + NADH + O2 => 9alpha-hydroxy-3-oxochol-4-en-22-oyl-CoA + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168885", "l": "Haptoglobin binds Hemoglobin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2129362", "l": "Fibrillin microfibril assembly (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5333051", "l": "RPA1 binds HSF1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38853", "l": "H2O + tetracenomycin F1 => H(+) + tetracenomycin F2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29350", "l": "2 H(+)(in) + orotate(in) <=> 2 H(+)(out) + orotate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41829", "l": "(3R)-hydroxyhexanoyl-[ACP] => (2E)-hexenoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32665", "l": "5-guanidino-3-methyl-2-oxopentanoate + H(+) + S-adenosyl-L-homocysteine => 5-guanidino-2-oxopentanoate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30992", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 24-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13600", "l": "1,4-diguanidinobutane + H2O <=> agmatine + urea"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050350", "l": "trihydroxystilbene synthase activity"}, {"i": "RHEA:11936", "l": "4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA = 4 CO2 + 4 CoA + trans-resveratrol"}, {"i": "EC:2.3.1.95", "l": "\"Trihydroxystilbene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626982", "l": "TNF-alpha:TNFR1:NSMAF binds GNB2L1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672969", "l": "Phosphorylation of RAF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45187", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + NH4(+) <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112385", "l": "Addition of nucleotides leads to transcript elongation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19220", "l": "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane <=> 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9668398", "l": "CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16709", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan"}, {"i": "EC:1.14.16.4", "l": "\"Tryptophan 5-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35217", "l": "H(+) + phosphate + XMP => H2O + XDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17853", "l": "keto-L-sorbose + O2 = 5-dehydro-D-fructose + H2O2"}, {"i": "EC:1.1.3.11", "l": "\"L-sorbose oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75172", "l": "Formation of RAD50:MRE11 complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21219", "l": "ATP + D-ribose 5-phosphate <=> ADP + alpha-D-ribose 1,5-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65173", "l": "(3Z,5E)-dodecadienoyl-CoA + H2O => (3Z,5E)-dodecadienoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41912", "l": "(2E)-hexadecenoyl-[ACP] + H(+) + NADPH = hexadecanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449115", "l": "IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682011", "l": "LC3 binds ATG7 dimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202721", "l": "JAM2 binds JAM3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76500", "l": "TBXAS1 isomerises PGH2 to TXA2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57153", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 => (3S)-3-hydroxy-L-lysyl-[protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018365", "l": "protein-serine epimerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24024", "l": "(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate = (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine"}, {"i": "EC:2.6.1.115", "l": "\"5-hydroxydodecatetraenal 1-aminotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22600", "l": "H2O + N-acetyl-9-O-acetylneuraminate = acetate + H(+) + N-acetylneuraminate"}, {"i": "RHEA:25564", "l": "H2O + N-acetyl-4-O-acetylneuraminate = acetate + H(+) + N-acetylneuraminate"}, {"i": "EC:3.1.1.53", "l": "\"Sialate O-acetylesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418553", "l": "cAMP degradation by Phosphodiesterases (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901974", "l": "glycerate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62669", "l": "deoxyherqueinone + H(+) + NADPH + O2 => H2O + herqueinone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613768", "l": "SOX10, POU3F1 and POU3F2 bind EGR2 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936642", "l": "deacetylation of O-acetylserine and sulfhydrylation using CysK1 (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019834", "l": "phospholipase A2 inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449087", "l": "CD4 binds Interleukin-16 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27613", "l": "formate + H(+) <=> CO2 + H2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13411", "l": "7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH => 7-aminomethyl-7-carbaguanine + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44796", "l": "2-demethylmenaquinol-13 + S-adenosyl-L-methionine = H(+) + menaquinol-13 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-448702", "l": "Caspase-1 active tetramer formation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033462", "l": "GGC codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6804099", "l": "HMGB1 binds LTP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33418", "l": "bornane-2,6-dione + H2O <=> [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55558", "l": "an oxoeicosatetraenoate + H2O => a hydroperoxyeicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36268", "l": "caffeine + H(+) + NADH + O2 => formaldehyde + H2O + NAD(+) + theobromine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981353", "l": "RASA1 stimulates RAS GTPase activity (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60233", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16290", "l": "(1R,2S)-ephedrine + NAD(+) => (R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52156", "l": "(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] = (R)-mandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.44", "l": "\"Phenylacetaldehyde oxime monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674022", "l": "BRAP autoubiquitinates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64988", "l": "CoA + H2O = adenosine 3',5'-bisphosphate + D-pantetheine 4'-phosphate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698000", "l": "FLT3 mutants:GRB2 bind GAB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733960", "l": "Bile salts and acids dissociate from ALB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48947", "l": "ADP + bacteriochlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate <=> 3-acetyl-3-devinylchlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46214", "l": "4-amino-5-aminomethyl-2-methylpyrimidine + formate => H2O + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4088130", "l": "PLK1 binds FOXM1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34329", "l": "1,4-benzoquinone + H2O + NADP(+) + nitrite => 4-nitrophenol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.322", "l": "\"(-)-endo-fenchol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2059926", "l": "NPHP4 protein binds LATS proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112690", "l": "PTPN11 binds CBL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29232", "l": "cyanate(in) + H(+)(in) => cyanate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59693", "l": "D-cellotriono-1,5-lactone + H2O => D-cellotrionate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682563", "l": "nsp12 misincorporates a nucleotide in nascent RNA minus strand (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014449", "l": "RHOG binds effectors at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69152", "l": "Removal of remaining Flap (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198983", "l": "NKG2D homodimer interacting with ligands (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33449", "l": "4-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADPH => 4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13484", "l": "ATP + L-methionine + tRNA(Met) <=> AMP + diphosphate + L-methionyl-tRNA(Met)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63813", "l": "ATP + N(8)-citryl-spermidine + spermidine => AMP + diphosphate + H(+) + N(8),N'(8)-citryl-bis(spermidine)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399930", "l": "Activation of PAK by Rac1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390425", "l": "FAR1 reduces PalmCoA to HXOL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9653514", "l": "USP17L2 deubiquitinates RCE1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12190", "l": "[dihydrolipoyllysine-residue succinyltransferase]-(R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysine + CO2 => 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase]-(R)-N(6)-lipoyl-L-lysine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47425", "l": "(2E,9Z)-octadecadienoyl-CoA + H2O => (3S)-hydroxy-(9Z-octadecenoyl)-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198270", "l": "PDPK1 phosphorylates AKT at T308 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114264", "l": "Translocation of activated BAX to the mitochondria (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473186", "l": "FSTL3 binds Activin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53304", "l": "AH2 + 2 ATP + 2 cob(II)alamin = A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051994", "l": "P-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102720", "l": "acetyl-coenzyme A:acetyl alcohol acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706336", "l": "Active FLT3 binds to SYK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32701", "l": "beta-sesquiphellandrene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034458", "l": "3'-5' RNA helicase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112395", "l": "Abortive termination of elongation after arrest (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17537", "l": "(R)-carnitinamide + H2O = (R)-carnitine + NH4(+)"}, {"i": "EC:3.5.1.73", "l": "\"Carnitinamidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63907", "l": "2 3-phenylpyruvate + H(+) <=> H2O + phenguignardate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54251", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18374", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070976", "l": "TIR domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39872", "l": "3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56639", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33339", "l": "(4R)-hydroxysphinganine + hexacosanoyl-CoA = CoA + H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44066", "l": "CoA + octyl hexadecanoyl => hexadecanoyl-CoA + octan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27831", "l": "neryl diphosphate => beta-phellandrene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653180", "l": "GABA translocates from cytosol to mitochondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389354", "l": "Activation of Vav1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35029", "l": "ADP + H(+) + phosphate + tungstate(out) => ATP + H2O + tungstate(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0016642", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor"}, {"i": "EC:1.4.4.-", "l": "\"With a disulfide as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36144", "l": "(2E)-hexadecenoyl-CoA + H(+) + NADPH => hexadecanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42003", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> H(+) + isogloboside iGb3Cer (d18:1(4E)) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050453", "l": "cob(II)alamin reductase activity"}, {"i": "RHEA:17481", "l": "2 cob(I)alamin + H(+) + NAD(+) = 2 cob(II)alamin + NADH"}, {"i": "EC:1.16.1.4", "l": "\"Cob(II)alamin reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41982", "l": "5alpha-pregnane-3,20-dione + H(+) + NADH => 3alpha-hydroxy-5alpha-pregnan-20-one + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22463", "l": "a 2,3-saturated acyl-CoA + NADP(+) <=> a 2,3-dehydroacyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047542", "l": "2-furoyl-CoA dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.32"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167284", "l": "7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625699", "l": "FOXO1 and NR3C1 bind TRIM63 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357472", "l": "PAK1-3 autophosphorylates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41134", "l": "1-decanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-decanoyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1299297", "l": "Activation of THIK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34103", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate"}, {"i": "EC:5.1.3.26", "l": "\"N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24529", "l": "(R)-lactaldehyde + NAD(+) => H(+) + methylglyoxal + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58401", "l": "heptan-1-ol + NADP(+) => H(+) + heptanal + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35736", "l": "a (2R)-2-hydroxycarboxylate + NADP(+) => a 2-oxocarboxylate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0051219", "l": "phosphoprotein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48486", "l": "an aliphatic alcohol + H(+) + propanoate => a propanoate ester + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43797", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938930", "l": "RUNX1 binds ELF2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60384", "l": "enterobactin + H2O = N-(2,3-dihydroxybenzoyl)-L-serine trimer"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702593", "l": "lestaurtinib-resistant FLT3 mutants don't bind lestaurtinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9692880", "l": "HRH3 binds Hist (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867613", "l": "PICALM binds R-SNAREs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670189", "l": "F8 variant does not bind the cell membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42100", "l": "ATP + carbamoyl phosphate + H2O + kanamycin A = 6''-O-carbamoylkanamycin A + AMP + diphosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109822", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66287", "l": "tomatidine + UDP-alpha-D-glucose <=> H(+) + tomatidine 3-O-beta-D-glucopyranoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225956", "l": "Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50114", "l": "CoA + H(+) + N-octadecanoyl-taurine => octadecanoyl-CoA + taurine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052725", "l": "inositol-1,3,4-trisphosphate 6-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004383", "l": "guanylate cyclase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.75", "l": "\"Lysostaphin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22915", "l": "L-valine + pyruvate <=> 3-methyl-2-oxobutanoate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61206", "l": "H(+) + 2 H2O + N(5)-[4-(S-L-cysteinyl-[protein])-5-methyl-1H-imidazol-2-yl]-L-ornithinyl-[protein] => L-arginyl-[protein] + L-cysteinyl-[protein] + methylglyoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72697", "l": "Start codon recognition (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42556", "l": "uridine(2819) in 21S rRNA = pseudouridine(2819) in 21S rRNA"}, {"i": "EC:5.4.99.43", "l": "\"21S rRNA pseudouridine(2819) synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022911", "l": "CSPG is secreted (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18829", "l": "4-phospho-D-erythronate + NAD(+) = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH"}, {"i": "EC:1.1.1.290", "l": "\"4-phosphoerythronate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44834", "l": "CoA + O-tetradecanoyl-(R)-carnitine => (R)-carnitine + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665871", "l": "ADRM1 binds 26S proteasome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008836", "l": "diaminopimelate decarboxylase activity"}, {"i": "RHEA:15101", "l": "H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine"}, {"i": "EC:4.1.1.20", "l": "\"Diaminopimelate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432054", "l": "Aquaporin-1 passively transports water out of cell (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30867", "l": "H2O + indole-3-acetaldehyde + NAD(+) = (indol-3-yl)acetate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22163", "l": "4-coumaroyl-CoA + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside <=> a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25818", "l": "3-aminopropanal + H2O2 + norspermidine => H2O + norspermine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61357", "l": "ATP + H2O + methotrexate(in) => ADP + H(+) + methotrexate(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1297333", "l": "Association of Acrosin Heavy and Light Chain (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47867", "l": "1,2,3-trioctanoylglycerol + H2O <=> dioctanoylglycerol + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9028730", "l": "Activated NTRK2 binds FRS2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49784", "l": "chenodeoxycholoyl-CoA + taurine = CoA + H(+) + taurochenodeoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17242", "l": "an alpha-amino acid ester + H2O => an alcohol + an alpha-amino acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9667965", "l": "ANKLE2 binds PP2A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68954", "l": "Mcm2-7 is phosphorylated by DDK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190245", "l": "FGFR1b binds to FGF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29248", "l": "3 H(+)(out) + 2 Na(+)(in) => 3 H(+)(in) + 2 Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64305", "l": "1-phenylpropylamine + pyruvate => 1-phenylpropan-1-one + L-alanine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031706", "l": "subtype 3 bombesin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72697", "l": "Start codon recognition (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26117", "l": "diphosphate + epi-cedrol => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35490", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2,3-dihydrogenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34772", "l": "a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) => a 3-oxosteroid + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351207", "l": "Spermine  => N-acetylated spermine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964278", "l": "G protein alpha (s):GTP binds SRC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45229", "l": "a (3E)-enoyl-CoA => a 4-saturated (2E)-enoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70501", "l": "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031755", "l": "Edg-2 lysophosphatidic acid receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41125", "l": "(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052741", "l": "(R)-limonene 6-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086077", "l": "gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64082", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) + holo-[ACP] => 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237129", "l": "Acireductone is created (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47311", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18768", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> a 1,2-diacyl-sn-glycerol + a sphingomyelin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35483", "l": "5alpha-cholest-7-en-3-one + S-adenosyl-L-methionine = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22765", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27616", "l": "di-trans,deca-cis-tridecaprenyl diphosphate + 10 diphosphate => (2Z,6E)-farnesyl diphosphate + 10 isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42532", "l": "uridine(55) in tRNA = pseudouridine(55) in tRNA"}, {"i": "EC:5.4.99.25", "l": "\"tRNA pseudouridine(55) synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782820", "l": "USP17 deubiquitinates SUDS3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35934", "l": "2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-glucose <=> 3''-deamino-3''-hydroxykanamycin X + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72691", "l": "Formation of the 43S pre-initiation complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66807", "l": "ferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + pisiferate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63134", "l": "cob(I)alamin--[alkylcobalamin reductase] + H(+) + S-methyl glutathione => apo--[alkylcobalamin reductase] + glutathione + methylcob(III)alamin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102052", "l": "indole-3-acetyl-proline synthetase activity"}, {"i": "MetaCyc:RXN-10434"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018686", "l": "6-hydroxy pseudo-oxynicotine monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40689", "l": "1-O-tetradecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + tetradecan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174916", "l": "Formation of N-glucuronides (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13320", "l": "(2R,3R)-tartrate + H(+) <=> (R)-glycerate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5688786", "l": "ATXN3 binds RAD23 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42317", "l": "a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] => an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68826", "l": "Free CDT1 associates with CDC6:ORC:origin complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810239", "l": "SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22849", "l": "(3S)-hydroxyoctanedioyl-CoA + NAD(+) => 3-oxooctanedioyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50524", "l": "acetyl-CoA + N-terminal L-methionyl-L-isoleucyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5607734", "l": "PKC-delta translocates to plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373745", "l": "SDK1 homophillic interaction (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20777", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose => myo-inositol + stachyose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19848", "l": "nocardicin E + S-adenosyl-L-methionine <=> H(+) + isonocardicin A + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39778", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 17,18-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47436", "l": "(2E,7Z)-hexadecadienoyl-CoA + H2O = (3S)-hydroxy-(7Z-hexadecenoyl)-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21908", "l": "NADP(+) + scytalone = H(+) + NADPH + naphthalene-1,3,6,8-tetrol"}, {"i": "EC:1.1.1.252", "l": "\"Tetrahydroxynaphthalene reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11807", "l": "an aromatic aldehyde + H2O + NAD(+) <=> an aromatic carboxylate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37949", "l": "12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043184", "l": "vascular endothelial growth factor receptor 2 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685290", "l": "SFTPD gene produces SFTPD protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21038", "l": "acetoacetyl-CoA + CoA => 2 acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30098", "l": "(S)-malate + a menaquinone <=> a menaquinol + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450187", "l": "TAK1 is activated within the TAK1 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0031992", "l": "energy transducer activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34217", "l": "4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH => 4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11356", "l": "A + H(+) + NADH = AH2 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156661", "l": "Formation of Exon Junction Complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814766", "l": "GDPD1 hydrolyzes LysoPtdCho (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696356", "l": "OSCAR binds collagen and SP-D (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707505", "l": "Hemes bind to CLEC1B dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0046983", "l": "protein dimerization activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68610", "l": "Formation of ORC(2-5) complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.14", "l": "\"Bile-salt sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22527", "l": "2 A + a carotenoid beta-end derivative <=> a carotenoid phi-end derivative + 2 AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938356", "l": "RMB14 binds RUNX2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18779", "l": "an alkane + Hg(2+) => an alkylmercury + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26062", "l": "[Co(I) methylamine-specific corrinoid protein] + H(+) + methylamine <=> [methyl-Co(III) methylamine-specific corrinoid protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37608", "l": "(6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202328", "l": "Translocation of PKC theta to plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654399", "l": "Activated FGFR2 binds FRS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62190", "l": "diphosphate + syn-isopimara-7,15-diene => 9alpha-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034859", "l": "benzothiazole monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1474210", "l": "Collagen type III degradation by MMP14 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12570", "l": "4-nitrocatechol + H2O + NAD(+) => 4-nitrophenol + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035487", "l": "thymine/thymine mispair binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64675", "l": "2-(methylsulfanyl)acetyl-CoA + butan-1-ol <=> butyl 2-(methylsulfanyl)acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41933", "l": "H2O + hexadecanoyl-[ACP] => H(+) + hexadecanoate + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20897", "l": "ATP + hydrogencarbonate + urea => ADP + H(+) + phosphate + urea-1-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21692", "l": "CDP-glycerol + H2O = CMP + 2 H(+) + sn-glycerol 3-phosphate"}, {"i": "EC:3.6.1.16", "l": "\"CDP-glycerol diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44315", "l": "1-tetradecanoylglycerol + H2O <=> glycerol + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19095", "l": "12,18-didecarboxysiroheme + 2 CO2 => 2 H(+) + siroheme"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22056", "l": "hexadecan-1-ol + NAD(+) = H(+) + hexadecanal + NADH"}, {"i": "EC:1.1.1.164", "l": "\"Hexadecanol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604360", "l": "Initial activation of proMMP2 by MMP14 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19693", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+) = 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.100", "l": "\"5-formyl-3-hydroxy-2-methylpyridine 4-carboxylate 5-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26541", "l": "hydrogencarbonate + NH4(+) + phosphate <=> carbamoyl phosphate + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44718", "l": "AH2 + all-trans-4,4'-diapolycopen-4-oate + H(+) => A + all-trans-4,4'-diapolycopen-4-al + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52947", "l": "cholate + UDP-alpha-D-glucuronate <=> choloyl-24-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102701", "l": "tricyclene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018766", "l": "dihydrophloroglucinol hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668395", "l": "CHMP7 binds CC2D1B (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.16"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58818", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate => ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57502", "l": "2-methyl-cis-aconitate + H2O => 3-hydroxybutane-1,2,3-tricarboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9680443", "l": "ROCK1,2 bind ROCKi (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex. (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045322", "l": "unmethylated CpG binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990699", "l": "palmitoleyl hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "81.20444558259193", "identifiers": [{"i": "GO:0016730", "l": "oxidoreductase activity, acting on iron-sulfur proteins as donors"}, {"i": "EC:1.18.-.-", "l": "\"Acting on iron-sulfur proteins as donors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1638845", "l": "CERK phosphorylates CERA to form C1P (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250947", "l": "B-WICH complex binds rDNA promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685319", "l": "CX3 complex formation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047995", "l": "hydroxyphenylpyruvate reductase activity"}, {"i": "RHEA:10780", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) = 3-(4-hydroxyphenyl)pyruvate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950757", "l": "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130349", "l": "Generation of CLIP from lip10 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381537", "l": "PAPP-A2 proteolyzes IGF:IGFBP5:ALS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668417", "l": "cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047301", "l": "valine-3-methyl-2-oxovalerate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "70.245698090881746", "identifiers": [{"i": "GO:0019955", "l": "cytokine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18603", "l": "3,4-dihydroxybenzoate + CO2 => 3,4-dihydroxyphthalate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638007", "l": "RP2 activates the GTPase activity of ARL3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674022", "l": "BRAP autoubiquitinates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59528", "l": "hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein] = CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9607301", "l": "Active FLT3:GRB2 binds SOS1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29769", "l": "ADP + D-methionine(in) + H(+) + phosphate => ATP + D-methionine(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296045", "l": "Activation of Potassium transport channels (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034577", "l": "N-isopropylacetaniline monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48142", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + red chlorophyll catabolite => 2 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53002", "l": "5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP => 17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216941", "l": "Phosphorylation of Chk1 by ATR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "78.047734625335977", "identifiers": [{"i": "GO:0004175", "l": "endopeptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016156", "l": "fumarate reductase (NADH) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55234", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 2 [Fe(III)-cytochrome b561] + H2O => 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 [Fe(II)-cytochrome b5] + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878654", "l": "ACP6 hydrolyses MYS-LPA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008744", "l": "L-xylulokinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.175", "l": "\"Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944219", "l": "Association of procollagen type XVI (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624953", "l": "ARL13B binds INPP5E (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61646", "l": "2 [Fe(III)-cytochrome b5] + H2O + L-arginine => 2 [Fe(II)-cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25969", "l": "(S)-benzoin + NADP(+) => benzil + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33349", "l": "glyoxylate + NH4(+) => 2-iminoacetate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66446", "l": "(E)-4-hexen-3-one + H(+) + NADPH => hexan-3-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944236", "l": "Association of procollagen type XIV (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050556", "l": "deacetylisoipecoside synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12772", "l": "A + D-gluconate <=> 2-dehydro-D-gluconate + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45550", "l": "(2R,3E)-phycoerythrobilin + apo-[R-phycocyanin alpha-subunit] => [R-phycocyanin alpha-subunit]-Cys(84)-phycourobilin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.14", "l": "\"N-acetylglucosamine-6-sulfatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12317", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27437", "l": "2 glutathione amide + H2O2 = glutathione amide disulfide + 2 H2O"}, {"i": "EC:1.11.1.17", "l": "\"Glutathione amide-dependent peroxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19494", "l": "D-cellobiose + phosphate => alpha-D-glucose 1-phosphate + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64935", "l": "dGTP + 2 H2O <=> dGMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9696274", "l": "RND1 binds GTP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36761", "l": "alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161948", "l": "Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045505", "l": "dynein intermediate chain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54101", "l": "N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75172", "l": "Formation of RAD50:MRE11 complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47622", "l": "2-ethylhexanal + CO2 + H(+) + succinate + sulfate => 2-ethylhexyl sulfate + 2-oxoglutarate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16761", "l": "chlorohydroquinone + O2 = 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55344", "l": "(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol = 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174963", "l": "NAT1 acetylation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75172", "l": "Formation of RAD50:MRE11 complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35654", "l": "(4R)-hydroxysphinganine + a fatty acyl-CoA <=> an N-acyl-(4R)-4-hydroxysphinganine + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33004", "l": "(+)-amorpha-4,11-diene + O2 + reduced [NADPH--hemoprotein reductase] => (+)-artemisinic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202174", "l": "Activation of ZAP-70 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106294", "l": "NADPH oxidase H202-forming activity"}, {"i": "RHEA:11260", "l": "H(+) + NADPH + O2 = H2O2 + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035716", "l": "chemokine (C-C motif) ligand 12 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46977", "l": "(S)-6-hydroxynicotine + O2 => 6-hydroxy-N-methylmyosmine + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450550", "l": "PKCalpha phosphorylates HuR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70510", "l": "LDH tetramer oxidises LACT to PYR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615829", "l": "IRAK1 gene expression is inhibited by MECP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25459", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-humulene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61300", "l": "5-deoxy-D-ribulose 1-phosphate = acetaldehyde + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392295", "l": "Gbeta:gamma recruits PI3K gamma (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12944", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693012", "l": "TNFSF15 binds TNFRSF25 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53496", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635868", "l": "ub-GLI is degraded by the proteasome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782879", "l": "TYW3 methylates yW-86 yielding yW-72 at nucleotide 37 of tRNA(Phe) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38971", "l": "O2 + octadecanoyl-CoA = (2E)-octadecenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901047", "l": "Binding of ERp57 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53432", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26405", "l": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4(+) = H(+) + 4 H2O + phosphate + pyridoxal 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5252133", "l": "ATP6AP1 binds V-ATPase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28324", "l": "UDP + wogonin 7-O-beta-D-glucuronate => UDP-alpha-D-glucuronate + wogonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9663511", "l": "BIL binds GSTA1, FABP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62865", "l": "7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + S-adenosyl-L-methionine => 9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099102", "l": "G-protein gated potassium channel activity involved in regulation of postsynaptic membrane potential"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0052842", "l": "inositol diphosphate pentakisphosphate diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218824", "l": "p-6Y-VEGFR2 binds FYN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008760", "l": "UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353277", "l": "Cleavage of thymine by 5-methylcytosine G/T mismatch specific glycosylase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50203", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47773", "l": "a guanosine in 21S rRNA + S-adenosyl-L-methionine => a 2'-O-methylguanosine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862300", "l": "LYZ binds bacterial peptidoglycan (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199518", "l": "C3d-complexed antigen binds to complement receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.14.-", "l": "\"Protein-arginine kinases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46486", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008768", "l": "UDP-sugar diphosphatase activity"}, {"i": "REACT:R-HSA-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43556", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59218", "l": "CO2 + skatole => (indol-3-yl)acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64764", "l": "S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine = 2-aminoprop-2-enoate + 3-methyl-3-sulfanylhexan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46571", "l": "5-hexenoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 5-hexynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36918", "l": "(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26052", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] => glyceollin III + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30193", "l": "15,9'-di-cis-phytofluene + plastoquinol-9 => 15-cis-phytoene + plastoquinone-9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-984733", "l": "Kinesin-3 is a dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68595", "l": "ORC2 binds ORC3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41418", "l": "1,2-dioctanoyl-sn-glycero-3-phosphate + choline + H(+) => 1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18806", "l": "[DsbA protein]-disulfide + [protein]-dithiol => [DsbA protein]-dithiol + [protein]-disulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42809", "l": "2 H(+) + 3 H2O + hydrogen sulfide + 3 oxidized coenzyme F420-(gamma-Glu)(n) => 3 reduced coenzyme F420-(gamma-Glu)(n) + sulfite"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050661", "l": "NADP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873918", "l": "Transphosphorylation of JAK1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12406", "l": "H(+) + lactose + UDP => D-glucose + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26484", "l": "diphosphate + N(6)-dimethylallyladenosine(37) in tRNA => adenosine(37) in tRNA + dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53106", "l": "4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine => 4-hydroxyestrone + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871193", "l": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26009", "l": "di-trans,nona-cis-dodecaprenyl phosphate + UDP-alpha-D-galacturonate <=> beta-D-galacturonosyl di-trans,nona-cis-dodecaprenyl phosphate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19358", "l": "H(+) + L-proline betaine + NADPH + O2 => formaldehyde + H2O + N-methyl-L-proline + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130640", "l": "Recruitment of clathrin coated vesicle by Ii (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43543", "l": "ATP + L-seryl-[isocitrate dehydrogenase] <=> ADP + H(+) + O-phospho-L-seryl-[isocitrate dehydrogenase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42524", "l": "uridine(1911/1915/1917) in 23S rRNA = pseudouridine(1911/1915/1917) in 23S rRNA"}, {"i": "EC:5.4.99.23", "l": "\"23S rRNA pseudouridine(1911/1915/1917) synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047331", "l": "diphosphate-glycerol phosphotransferase activity"}, {"i": "MetaCyc:2.7.1.79-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099635", "l": "voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65060", "l": "NADP(+) + taurochenodeoxycholate = 7-oxotaurolithocholate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008684", "l": "TBK1 phosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665405", "l": "ERBB2 ECD mutants bind trastuzumab (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43202", "l": "2'-O-methylcytidine(1920) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1920) in 23S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3266557", "l": "Factor I cleaves iC3b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.89"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956659", "l": "ABL1 phosphorylates YAP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5678327", "l": "MIOX oxidises Ins to GlcA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810392", "l": "TMEM55B translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57749", "l": "2 (S)-methylmalonyl-CoA + 10 H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 3 malonyl-CoA + 5 NADPH => C32-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43910", "l": "D-galactose + sphing-4-enine => beta-D-galactosyl-(1<->1)-sphing-4-enine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49717", "l": "3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + H(+) + NADH + O2 => 3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9021596", "l": "Membrane estrogen receptors bind SRC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622390", "l": "Activation of TRPC channels by Netrin-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52784", "l": "2-sulfenohercynine + AH2 + H(+) = A + ergothioneine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114553", "l": "Activation of conventional Protein Kinase C (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212380", "l": "Formation of TRAP coactivator complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22455", "l": "[phosphate](n+1) + n H2O <=> n H(+) + (n+1) phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20276", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 <=> (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0008309", "l": "double-stranded DNA exodeoxyribonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956365", "l": "ZBED1 (DREF) SUMOylates CHD3 with SUMO1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51140", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + 2 O2 = (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E)-docosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851888", "l": "MET binds SHC1-2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32685", "l": "2,5-dicarboxyfuran + 2 H(+) + 3 H2O2 => 5-hydroxymethylfurfural + 2 H2O + 3 O2"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0016672", "l": "oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor"}, {"i": "EC:1.8.5.-", "l": "\"With a quinone or similar compound as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63375", "l": "an acyl-CoA + L-cysteinyl-[protein] <=> an S-acyl-L-cysteinyl-[protein] + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655240", "l": "Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863471", "l": "LDLR is bound by DAB2 and ARH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32820", "l": "chromate(in) => chromate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14109", "l": "L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40519", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191790", "l": "Loading and methylation of Sm proteins onto SMN Complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173636", "l": "Formation of classic pathway C5 convertase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9619756", "l": "NR1H2 binds ABCA1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674018", "l": "BRAP binds RAS:GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0036441", "l": "2-dehydropantolactone reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42760", "l": "D-glyceraldehyde 3-phosphate + H2O + NAD(+) = (2R)-3-phosphoglycerate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694442", "l": "CNIH2,3 bind GRIA1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5333051", "l": "RPA1 binds HSF1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61405", "l": "ATP + N-(D-ribulosyl)-cadaverine => ADP + H(+) + N-(3-O-phospho-D-ribulosyl)-cadaverine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691131", "l": "CANDI binds CUL1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798749", "l": "Exocytosis of specific granule lumen proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38816", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33000", "l": "(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => (+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5221061", "l": "TDG excises 5-carboxylcytosine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640368", "l": "Addition of Tegument to HCMV Nucleocapsid C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.13", "l": "\"Iduronate-2-sulfatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852010", "l": "BTNL2 binds activated T cells surface (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40292", "l": "ATP + CoA + tetradecanedioate => AMP + diphosphate + tetradecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950778", "l": "p-Y693-STAT4 dimerizes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40828", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.120", "l": "\"Oviductin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10684", "l": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate"}, {"i": "EC:3.1.3.48", "l": "\"Protein-tyrosine-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31206", "l": "acetyl-CoA + hexanoyl-CoA <=> 3-oxooctanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483087", "l": "PI is exchanged with PC by PITPNB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56597", "l": "(1S,4S)-bornane-2,5-dione + FMNH2 + O2 => (1S,4S)-5-oxo-1,2-campholide + FMN + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32932", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2-diacyl-sn-glycerol => a cardiolipin + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17267", "l": "cis-aconitate => trans-aconitate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50700", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = calcitriol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5250947", "l": "B-WICH complex binds rDNA promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195275", "l": "Phosphorylation of APC component of the destruction complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193695", "l": "IRAK interacts with TRAF6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426032", "l": "DAG is metabolized by DAGL to 2-AG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25988", "l": "(5R)-albaflavenol + H(+) + NADPH + O2 = albaflavenone + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30333", "l": "all-trans-zeaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => all-trans-beta-carotene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10447", "l": "(S)-reticuline + S-adenosyl-L-methionine <=> (S)-laudanine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654422", "l": "Activated FGFR4 binds FRS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41642", "l": "3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate => 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-873917", "l": "Translocation of STAT1 dimer to nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57411", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + NAD(+) <=> 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50629", "l": "a 2-(omega-methylsulfanyl)alkylmalate => a 3-(omega-methylsulfanyl)alkylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676596", "l": "TRAF3 binds BAFFR:BAFF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59231", "l": "6-sulfo-alpha-D-quinovose <=> 6-sulfo-beta-D-quinovose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36011", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16196", "l": "an (R)-2-haloacid + H2O <=> a (2R)-2-hydroxycarboxylate + a halide anion + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879459", "l": "F-actin capping protein is a heterodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390663", "l": "ADRA2A,B,C bind ADR,NAd (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16658", "l": "H2O + inosine => D-ribose + hypoxanthine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008139", "l": "nuclear localization sequence binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980061", "l": "JAG2 binds NOTCH2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047356", "l": "CDP-ribitol ribitolphosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33430", "l": "(S)-malyl alpha-D-glucosaminide + L-cysteine <=> bacillithiol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29535", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}, {"i": "EC:2.4.1.260", "l": "\"Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683831", "l": "CCDC59 binds TTF1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247836", "l": "Retromer recycles WLS to the Golgi (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848414", "l": "Activated PTK6 binds CDKN1B (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41059", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + octadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15828", "l": "AZD1979 + H2O <=> AZD1979 oxetane hydrolysis product + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983156", "l": "Polyubiquitination of substrate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11786", "l": "H(+) + NADPH + NH4(+) + oxaloacetate => H2O + L-aspartate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.3.-", "l": "\"Oximinotransferases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31101", "l": "(2E)-2-methylpropenoyl-CoA + FADH2 => 2-methylpropanoyl-CoA + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63210", "l": "5-(2-oxoethylideneamino)-6-(D-ribitylamino)uracil + H2O => 5-amino-6-(D-ribitylamino)uracil + glyoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24579", "l": "diphosphate + H2O <=> H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40683", "l": "1-hexadecanoylglycerone 3-phosphate + dodecan-1-ol = 1-O-dodecylglycerone 3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616367", "l": "NAB2 binds EGR1 to repress CDK5R1 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42207", "l": "corticosterone + NAD(+) <=> 11-dehydrocorticosterone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57387", "l": "(13S,14R)-1,13-dihydroxy-N-methylcanadine + acetyl-CoA <=> (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42314", "l": "NADPH + 2 oxidized [adrenodoxin] => H(+) + NADP(+) + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50789", "l": "NADP(+) + pentan-2-one => (E)-pent-3-en-2-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54710", "l": "H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53390", "l": "5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] + H(+) + UDP => 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25365", "l": "H(+) + momilactone A + NADH => 3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215426", "l": "COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16751", "l": "acetate + H(+) + phosphate => H2O + phosphonoacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57584", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a 2-hydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.162", "l": "\"Flavanone 2-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25965", "l": "(R)-benzoin + NADP(+) => benzil + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43301", "l": "alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-glycoloylneuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17932", "l": "an N-acylsphing-4-enine + ATP <=> ADP + an N-acylsphing-4-enine 1-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161791", "l": "15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49735", "l": "H(+) + O2 + violaceinate <=> CO2 + H2O + violacein"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17185", "l": "IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH"}, {"i": "EC:1.7.1.7", "l": "\"GMP reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390674", "l": "ADRB1 bind ADR,NAd (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708466", "l": "BACH1 translocates from the nucleoplasm to the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41680", "l": "a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+) = a 2-all-trans-polyprenylphenol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953013", "l": "E2F7 binds E2F8 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193684", "l": "p62 recruits an atypical PKC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65473", "l": "2-methylbutanoyl-CoA + ethanol => CoA + ethyl 2-methylbutanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043924", "l": "suramin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862280", "l": "FCHo proteins bind nascent clathrin-coated pit (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371567", "l": "DBC1 is phosphorylated by ATM/ART (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44116", "l": "eicosan-1-ol + hexadecanoyl-CoA = CoA + eicosanyl hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44647", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O <=> a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983259", "l": "Kinesins move along microtubules consuming ATP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6813749", "l": "ALDH1A1 oxidises GA to DGA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40881", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74715", "l": "Autophosphorylation of insulin receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42043", "l": "ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose <=> gangliosideFuc-GM1 (d18:1(4E)) + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654163", "l": "Activated FGFR4 binds PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51597", "l": "2 H(+) + O2 + p-xylene + 2 reduced [2Fe-2S]-[ferredoxin] => 4-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33985", "l": "diphosphate + miltiradiene => (+)-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47506", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => chenodeoxycholate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28251", "l": "acetyl-CoA + H(+) + malonyl-CoA => acetoacetyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16763", "l": "5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H(+) => chlorohydroquinone + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814094", "l": "ARL1:GTP binds ARFIP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034000", "l": "chondroitin-sulfate-ABC endolyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159194", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45507", "l": "[C-phycoerythrin alpha-subunit]-Cys(84)-phycoerythrobilin <=> (2R,3E)-phycoerythrobilin + apo-[C-phycoerythrin alpha-subunit]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27694", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41904", "l": "3-oxohexadecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16505", "l": "chorismate = 4-hydroxybenzoate + pyruvate"}, {"i": "EC:4.1.3.40", "l": "\"Chorismate lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62967", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP-beta-L-fucose <=> alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28195", "l": "(S)-3-sulfolactate + NAD(+) => 3-sulfopyruvate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654425", "l": "Activated FGFR4 binds SHC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0097245", "l": "flavanol binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052635", "l": "C-20 gibberellin 2-beta-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "80.661393760018115", "identifiers": [{"i": "GO:0005416", "l": "amino acid:cation symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45743", "l": "2-oxoglutarate + L-ectoine + O2 <=> 5-hydroxyectoine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668335", "l": "CHMP7 binds LEMD2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20891", "l": "3-hydroxy-2-methylpropanoyl-CoA + H2O <=> 3-hydroxy-2-methylpropanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34701", "l": "(-)-alpha-isocomene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686920", "l": "PELI1 ubiquitinates RIPK3 at K363 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58858", "l": "(6E)-8-oxogeraniol + H(+) + NADH => (6E)-8-hydroxygeraniol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18146", "l": "ATP + beta-D-fructose => ADP + beta-D-fructose 1-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44513", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.n1", "l": "\"Cytokinin riboside 5'-monophosphate phosphoribohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176175", "l": "Stalling of DNA replication fork and RPA binding (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9652264", "l": "ERBB2 binds TKIs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38040", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3095901", "l": "ABCC1 transports cytosolic Cbl to extracellular region (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429767", "l": "Passive I- efflux mediated by SMCT1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49912", "l": "(R)-carnitine(out) + O-propanoyl-(R)-carnitine(in) = (R)-carnitine(in) + O-propanoyl-(R)-carnitine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21533", "l": "ATP + glutathione + glutathionylspermidine => ADP + H(+) + phosphate + trypanothione"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004578", "l": "chitobiosyldiphosphodolichol beta-mannosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55753", "l": "2 CO2 + coenzyme B + coenzyme M + 2 reduced [2Fe-2S]-[ferredoxin] => coenzyme M-coenzyme B heterodisulfide + 2 formate + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32073", "l": "(13E)-labda-7,13-dien-15-yl diphosphate => geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683429", "l": "nsp16 binds nsp10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10011", "l": "[protein]-dithiol + a hydroperoxide <=> [protein]-disulfide + an alcohol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58457", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O => (R)-glycerate + D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2106614", "l": "Duplex miRNA is loaded into Argonaute (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654425", "l": "Activated FGFR4 binds SHC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62330", "l": "(+)-malbrancheamide + FADH2 => (+)-isomalbrancheamide B + chloride + FAD + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937177", "l": "AHR:TCDD binds ARNT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43180", "l": "cytidine(2278) in 25S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(2278) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.311", "l": "\"25S rRNA (cytosine(2278)-C(5))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672969", "l": "Phosphorylation of RAF (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46811", "l": "[trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine <=> [trehalose-6-phosphate synthase]-S-methyl-L-cysteine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32211", "l": "(Z)-5-oxohex-2-enedioate = (2E,4Z)-2-hydroxyhexa-2,4-dienedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15872", "l": "2-oxoglutarate + D-alanine <=> D-glutamate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662986", "l": "MT2A binds copper (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23493", "l": "UDP-alpha-D-glucosamine => UDP-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33161", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+) => H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54410", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10653", "l": "a long-chain fatty aldehyde + H2O + NAD(+) => a long-chain fatty acid + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15525", "l": "2-succinylbenzoyl-CoA = 1,4-dihydroxy-2-naphthoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45051", "l": "acetamide + H2O <=> acetate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0005280", "l": "amino acid:proton symporter activity"}, {"i": "REACT:R-HSA-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909720", "l": "IFN alpha/beta binds to IFNAR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35019", "l": "L-threonine(in) = L-threonine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-517731", "l": "Expression of IL-8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39264", "l": "(2E,13Z)-docosadienoyl-CoA + H(+) + NADPH => (13Z)-docosenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8980691", "l": "RHOA GEFs activate RHOA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10179", "l": "(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+) <=> (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34919", "l": "thiamine(in) = thiamine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31709", "l": "2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al => 2 H(+) + O2 + pentalen-13-ol + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391913", "l": "FPR2 binds FPR2 ligands (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102094", "l": "S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24022", "l": "fumarate + L-arginine => 2-(N(omega)-L-arginino)succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22311", "l": "O2 + xylitol <=> D-xylose + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54064", "l": "(2E,6E)-farnesyl diphosphate + H2O = 10-epi-cubebol + diphosphate"}, {"i": "EC:4.2.3.175", "l": "\"10-epi-cubebol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664867", "l": "NBR1 binds MAP1LC3B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948230", "l": "P3HB binds 4-Hyp-collagen propeptides (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32103", "l": "2 S-adenosyl-L-methionine + trans-resveratrol = 2 H(+) + pterostilbene + 2 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.240", "l": "\"Trans-resveratrol di-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420206", "l": "Phosphorylation of SRC-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211224", "l": "Anthrax cya catalyzes the conversion of ATP to cAMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177479", "l": "Axonal transport of NGF:Trk complexes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102411", "l": "quercetin-3,4'-O-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-13766"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58528", "l": "15alpha-stemmadenine intermediate I + H2O + NADPH = (16R)-deshydroxymethyl-stemmadenine + formate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11833", "l": "(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) => H(+) + NADH + naphthalene-1,2-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60877", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O => a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50189", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 => N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35233", "l": "rifampicin(out) => rifampicin(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446322", "l": "PARVA associates with Paxillin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64996", "l": "ATP + H(+) + octanoate = diphosphate + octanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27962", "l": "myo-inositol + pyrroloquinoline quinone = H(+) + pyrroloquinoline quinol + scyllo-inosose"}, {"i": "EC:1.1.5.n1", "l": "\"Quinoprotein inositol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19210", "l": "codeine + NADP(+) => codeinone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33860", "l": "(2S-3S)-versiconal hemiacetal => H2O + versicolorin B"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033930", "l": "keratan-sulfate endo-1,4-beta-galactosidase activity"}, {"i": "MetaCyc:3.2.1.103-RXN"}, {"i": "EC:3.2.1.103", "l": "\"Keratan-sulfate endo-1,4-beta-galactosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120226", "l": "succinyl-CoA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20830", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2 => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22526", "l": "a carotenoid phi-end derivative + 2 AH2 => 2 A + a carotenoid beta-end derivative"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1606583", "l": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201669", "l": "Beta-catenin translocates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50374", "l": "an N-acylsphingoid base 1-phosphate(out) => an N-acylsphingoid base 1-phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40810", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2186771", "l": "RNF111 binds SMAD7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39491", "l": "(2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH = (11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32201", "l": "9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => androsta-1,4-diene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53366", "l": "H(+) + NADH + uridine(47) in tRNA => 5,6-dihydrouridine(47) in tRNA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31632", "l": "2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H2O + phosphoenolpyruvate => phosphate + pseudaminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13947", "l": "(R)-mandelate => (S)-mandelate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66416", "l": "ATP + glutathione(in) + glycoursodeoxycholate(in) + H2O = ADP + glutathione(out) + glycoursodeoxycholate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102505", "l": "apigeninidin 5-O-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-14427"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2453818", "l": "Defective STRA6 does not transport atROL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8873794", "l": "PCTP binds PC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132088", "l": "Vitronectin prevents C9 polymerization (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26125", "l": "FAD + L-proline => (S)-1-pyrroline-5-carboxylate + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43287", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31198", "l": "(3S)-hydroxyoctanoyl-CoA + NAD(+) <=> 3-oxooctanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66490", "l": "quillaic acid 28-beta-D-glucoside + UDP => quillate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421478", "l": "coproporphyrinogen III + 2 O2 => protoporphyrinogen IX + 2 H2O2 + 2 CO2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683648", "l": "Spike trimer glycoside chains are extended (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416516", "l": "GRK2 sequesters activated Gq (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592278", "l": "Autocatalytic activation of proMMP2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35700", "l": "(S)-versiconol + NADP(+) => (2S-3S)-versiconal hemiacetal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5695980", "l": "ACAD10 dehydrogenates S-2MPDA-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51169", "l": "(R)-adrenaline + H2O + O2 => 3,4-dihydroxymandelaldehyde + H2O2 + methylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39206", "l": "(2E)-tetracosenoyl-CoA + H(+) + NADPH <=> NADP(+) + tetracosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.45"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25537", "l": "ent-copalyl diphosphate => diphosphate + ent-sandaracopimara-8(14),15-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654603", "l": "Activated FGFR2 binds FRS3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0003884", "l": "D-amino-acid oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-532603", "l": "Nephrin mediated activation of N-WASP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422454", "l": "Polysialylation of NCAM1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166792", "l": "Conversion of C2 into C2a and C2b (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2002428", "l": "Removal of fibrillar collagen N-propeptides (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34157", "l": "CoA + H(+) + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose => acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296045", "l": "Activation of Potassium transport channels (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693929", "l": "RIPK1 variant is not cleaved by CASP8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004021", "l": "L-alanine:2-oxoglutarate aminotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0016802", "l": "trialkylsulfonium hydrolase activity"}, {"i": "EC:3.3.1.-", "l": "\"Thioether and trialkylsulfonium hydrolases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29139", "l": "2 H(+)(in) + menaquinol-8 + nitrate = 2 H(+)(out) + H2O + menaquinone-8 + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10943", "l": "(2E)-geranyl diphosphate <=> (4R)-limonene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33480", "l": "an acyl-CoA + lanosterol => CoA + lanosteryl ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156678", "l": "Activation of Cdc25C (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25445", "l": "(2E,6E)-farnesyl diphosphate => (1E,4E)-germacrene B + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18596", "l": "sphinganine 1-phosphate <=> hexadecanal + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690669", "l": "CD22 binds itself to form homo-oligomers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46911", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA <=> 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + a 1,2-diacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23092", "l": "H(+) + H2O + hydroxyatrazine = ethylamine + N-isopropylammelide"}, {"i": "EC:3.5.4.43", "l": "\"Hydroxydechloroatrazine ethylaminohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16926", "l": "(E)-caffeoyl-CoA + S-adenosyl-L-methionine => (E)-feruloyl-CoA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16267", "l": "5-O-[(E)-caffeoyl]-D-quinate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + trans-5-O-(4-coumaroyl)-D-quinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018615", "l": "2-indanone monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38638", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40975", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O = 2 H(+) + 2 hexadecanoate + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61611", "l": "[DsbB protein]-dithiol + a quinone <=> [DsbB protein]-disulfide + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33984", "l": "(+)-copalyl diphosphate => diphosphate + miltiradiene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9626928", "l": "CREBBP binds FOXO1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29746", "l": "2-phenylethylamine(in) <=> 2-phenylethylamine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41519", "l": "O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15279", "l": "CoA + H(+) + N(6)-acetyl-L-lysyl-[alpha-tubulin] => acetyl-CoA + L-lysyl-[alpha-tubulin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14501", "l": "H2O + L-homocysteine = 2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+)"}, {"i": "EC:4.4.1.2", "l": "\"Homocysteine desulfhydrase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23627", "l": "a 5,6-dihydrouridine in tRNA + NADP(+) <=> a uridine in tRNA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75146", "l": "TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3159253", "l": "MMAB transfers adenosyl group from ATP to cob(I)alamin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48113", "l": "N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine => H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65098", "l": "a 1-hexadecanoyl-2-acylglycerol + CoA => a 2-acylglycerol + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57530", "l": "5'-phospho-ribonucleosidyl-ribonucleotide-RNA + AMP + 2 diphosphate + H(+) => 5'-end ribonucleotide-RNA + a ribonucleoside 5'-triphosphate + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29829", "l": "Mg(2+)(out) => Mg(2+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71495", "l": "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21126", "l": "5-methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine => cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120242", "l": "2-iminobutanoate deaminase activity"}, {"i": "RHEA:39975", "l": "2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29386", "l": "dIMP + H2O <=> 2'-deoxyinosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112271", "l": "The receptor:G-protein complex dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694520", "l": "nsp16 binds VHL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193786", "l": "3,7,24THCA is translocated from the mitochondrial matrix to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653886", "l": "B4GALT1 binds LALBA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40823", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35056", "l": "3,6-dichlorocatechol + O2 => (2E,4E)-2,5-dichloromuconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31627", "l": "10-deoxymethynolide + dTDP-alpha-D-desosamine = 10-deoxymethymycin + dTDP + H(+)"}, {"i": "EC:2.4.1.277", "l": "\"10-deoxymethynolide desosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396401", "l": "NOTCH1 PEST domain mutants bind HES5 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102232", "l": "acrolein reductase activity"}, {"i": "MetaCyc:RXN-12281"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809764", "l": "SBF1 binds MTMR2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50762", "l": "a quinol + sulfate => a quinone + H2O + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220978", "l": "FBXW7 WD mutants do not bind NICD1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43698", "l": "diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] => H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156910", "l": "Formation of eEF1B complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399952", "l": "Phosphorylation of LIMK-1 by PAK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1362416", "l": "Frataxin binds iron (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61433", "l": "(R)-8-oxocitronellyl enol + NADP(+) => (6E)-8-oxogeranial + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16059", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034432", "l": "bis(5'-adenosyl)-pentaphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45909", "l": "chloroorienticin B + dTDP-beta-L-vancosamine => chloroeremomycin + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814695", "l": "PERP binds desmosomes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30310", "l": "7-methylxanthine + H(+) + NADPH + O2 <=> formaldehyde + H2O + NADP(+) + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65553", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O => an N-acyl-sphingoid base + lactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712079", "l": "ALK mutants bind STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52282", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4,5-trihydroxybenzoate => (6S)-5,6,7,8-tetrahydrofolate + 3-O-methylgallate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008822", "l": "PPM1D dephosphorylates RUNX2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29683", "l": "alpha-maltohexaose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltopentaose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050572", "l": "L-idonate 5-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47033", "l": "AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA => 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28431", "l": "D-allose 6-phosphate => D-allulose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58675", "l": "D-glucuronate <=> aldehydo-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030747", "l": "indolepyruvate C-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27446", "l": "NADP(+) + xylitol => D-xylose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800315", "l": "MST1 binds MST1R (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112429", "l": "Formation of FACT complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944246", "l": "Association of procollagen type XXI (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40638", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O <=> 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11515", "l": "salicyl alcohol + UDP-alpha-D-glucose <=> H(+) + salicin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40509", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61594", "l": "3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + 2 H(+) + hydrogen sulfide + L-methionine => H2O + L-cysteinyl-[sulfatase] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59477", "l": "2 AH2 + 2 ATP + benzoate + L-phenylalanine => 2 A + 2 AMP + 2 diphosphate + H(+) + N-benzoyl-L-phenylalaninol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034714", "l": "type III transforming growth factor beta receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-453338", "l": "PGYM b dimer:AMP complex <=> PGYM dimer, b form + 2 AMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021609", "l": "ESR-associated SRC autophosphorylates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62847", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-fucose <=> beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-D-glucosamine + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050060", "l": "long-chain-alcohol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390425", "l": "FAR1 reduces PalmCoA to HXOL (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51386", "l": "CoA + H(+) + N-hexadecanoyl-serotonin => hexadecanoyl-CoA + serotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22206", "l": "H2O + homogentisate + NADP(+) => 3-hydroxyphenylacetate + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55222", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O => 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372819", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49998", "l": "(25R)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54300", "l": "n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate = n adenosine 3',5'-bisphosphate + chondroitin 4',6'-disulfate + n H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22242", "l": "N-(carboxyaminomethyl)urea + NH4(+) => H2O + methylenediurea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.55", "l": "\"2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39348", "l": "(2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADPH => (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706319", "l": "Active FLT3 binds to SLA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12093", "l": "(S)-acetoin => (R)-acetoin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388817", "l": "ICOS binds ICOSL/B7-H2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-169719", "l": "Secreted CD14 binds LPS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40201", "l": "16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166538", "l": "The bound receptor dimerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60368", "l": "urate(out) = urate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196026", "l": "Dab2 is recruited to the junctional plaques (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811412", "l": "Active ARF recruits coatomer to the Golgi (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54154", "l": "a 2'-O-methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine => a uridine in rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696807", "l": "N-glycan mannose trimming of Spike (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25433", "l": "beta-D-ribopyranose => beta-D-ribofuranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27392", "l": "(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O <=> pyruvate + salicylaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670428", "l": "KIT mutants bind GRB2-SOS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60581", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38301", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.7.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709396", "l": "CO translocates from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20160", "l": "2n [Fe(III)cytochrome c] + a polyvinyl alcohol <=> 2n [Fe(II)cytochrome c] + an oxidized polyvinyl alcohol + 2n H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36269", "l": "formaldehyde + H2O + NAD(+) + theobromine => caffeine + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56271", "l": "CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> CMP + H(+) + N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10913", "l": "(R)-pantoate + ATP + beta-alanine => (R)-pantothenate + AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61605", "l": "[DsbA protein]-dithiol + [DsbB protein]-disulfide => [DsbA protein]-disulfide + [DsbB protein]-dithiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014812", "l": "ROBOs bind keratan sulfate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25077", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate <=> (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050225", "l": "pseudouridine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76416", "l": "Benzene is hydroxylated to phenol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32550", "l": "(2E)-geranyl diphosphate <=> (1R,5R)-sabinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45086", "l": "7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14647", "l": "H(+) + L-homoserine + S-methyl-5'-thioadenosine => H2O + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32664", "l": "5-guanidino-2-oxopentanoate + S-adenosyl-L-methionine => 5-guanidino-3-methyl-2-oxopentanoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16166", "l": "L-tryptophan + O2 => CO2 + H2O + indole-3-acetamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35837", "l": "kanamycin A + NADP(+) => 2'-dehydrokanamycin A + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30703", "l": "H(+) + salicylate = CO2 + phenol"}, {"i": "EC:4.1.1.91", "l": "\"Salicylate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59699", "l": "D-cellotetraono-1,5-lactone + H2O <=> D-cellotetraonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.164"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12052", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + trichodiene"}, {"i": "EC:4.2.3.6", "l": "\"Trichodiene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997381", "l": "TDPK phosphorylates ThDP to ThTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23671", "l": "apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin <=> AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63880", "l": "2 [Fe(III)cytochrome c] + H2O + thiocyanate = 2 [Fe(II)cytochrome c] + cyanate + 2 H(+) + sulfur"}, {"i": "EC:1.8.2.7", "l": "\"Thiocyanate desulfurase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44076", "l": "ATP + CoA + pentadecanoate = AMP + diphosphate + pentadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25662", "l": "(2E)-geranyl diphosphate = alpha-pinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43445", "l": "1,2-ditetradecanoyl-sn-glycerol + ATP => 1,2-ditetradecanoyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57474", "l": "1-O-(trans-4-coumaroyl)-beta-D-glucose + UDP => (E)-4-coumarate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202714", "l": "CD58 binds CD2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38553", "l": "(R)-2-hydroxyhexadecanoate + 2 [Fe(III)-cytochrome b5] + H2O => 2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987223", "l": "IL10RB binds TYK2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015548", "l": "organomercurial transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0016805", "l": "dipeptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64202", "l": "a fatty acid + L-leucine => an N-(fatty acyl)-L-leucine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26251", "l": "2 H2O + levopimaradienal + NADP(+) => H(+) + levopimaradienol + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32371", "l": "all-trans-violaxanthin + 2 L-ascorbate = all-trans-zeaxanthin + 2 H2O + 2 L-dehydroascorbate"}, {"i": "EC:1.23.5.1", "l": "\"Violaxanthin de-epoxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19059", "l": "a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O => a hydroperoxy polyunsaturated fatty acid + 2 glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70573", "l": "argininosuccinate <=> fumarate + arginine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22025", "l": "H2O + NAD(+) + trimethylamine => 2 H(+) + NADH + trimethylamine N-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1449687", "l": "Corticosteroids bind to CBG in blood (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50990", "l": "prostaglandin F2alpha(in) => prostaglandin F2alpha(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34508", "l": "2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate => N,N-diacetyllegionaminate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16720", "l": "deoxycholate + FAD + H(+) + H2O <=> cholate + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204392", "l": "Basigin binds MCT1, MCT3 and MCT4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685956", "l": "3a is externalized together with membrane structures (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428752", "l": "Dissociation of the TP:Gq complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004890", "l": "GABA-A receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46406", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O => 2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31674", "l": "dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine <=> dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11576", "l": "ATP + thiamine = AMP + H(+) + thiamine diphosphate"}, {"i": "EC:2.7.6.2", "l": "\"Thiamine diphosphokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39495", "l": "3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791057", "l": "Expression of TSPYL2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15638", "l": "[alginate](n) + GDP-alpha-D-mannuronate => [alginate](n+1) + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19462", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106369", "l": "GTP dependent (deoxy)nucleoside -phosphate kinase activity"}, {"i": "RHEA:62124", "l": "a 2'-deoxyribonucleoside 5'-phosphate + GTP = a 2'-deoxyribonucleoside 5'-diphosphate + GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416698", "l": "SEMA5A binds to PLXNB3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38111", "l": "glycerol + NADP(+) = H(+) + L-glyceraldehyde + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39352", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA => (2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52105", "l": "a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952823", "l": "p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109700", "l": "AKT2 binds PIP3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617179", "l": "PRKACA phosphorylates TNNI3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16641", "l": "a long-chain fatty acyl ethyl ester + H2O = a long-chain fatty acid + ethanol + H(+)"}, {"i": "EC:3.1.1.67", "l": "\"Fatty-acyl-ethyl-ester synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23981", "l": "cyclomaltodextrin + H2O => linear maltodextrin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685603", "l": "SAP and EAT2 binds SLAMF6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64843", "l": "2-phenylethanol + benzoyl-CoA <=> CoA + phenethyl benzoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60765", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-cinerolone => cinerin II + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629918", "l": "NEIL1 translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990471", "l": "piRNA uni-strand cluster binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018479", "l": "benzaldehyde dehydrogenase (NAD+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9007539", "l": "CHEK1 phosphorylates E2F6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017188", "l": "aspartate N-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13383", "l": "a carboxylate + acetyl-CoA => acetate + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952419", "l": "SMURFs ubiquitinate RUNX3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9625482", "l": "PTK2 binds activated EGFR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37367", "l": "CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine = 2,3-bis-O-phytanyl-sn-glycero-3-phospho-L-serine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58621", "l": "N-decanoyl-(2S)-hydroxyglycine => decanamide + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65257", "l": "AH2 + O2 + verruculide C => A + H2O + verruculide C epoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604752", "l": "Initial activation of proMMP13 by MMP3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419049", "l": "ROCK activation by RHO (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981353", "l": "RASA1 stimulates RAS GTPase activity (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805943", "l": "S100A1 binds TLR4:LY96 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210892", "l": "cya and lef bind to pagA(197-794):ANTXR2 oligomer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22341", "l": "3-hydroxybenzyl alcohol + NADP(+) => 3-hydroxybenzaldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696947", "l": "USP47 deubiquitinates POLB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23285", "l": "isopentenyl diphosphate => dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44351", "l": "ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide B + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61786", "l": "keto-L-fructose => L-allulose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036192", "l": "3-hydroxyindolin-2-one monooxygenase activity"}, {"i": "RHEA:31927", "l": "3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.109", "l": "\"3-hydroxyindolin-2-one monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42998", "l": "(R)-cembrene A + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28767", "l": "ethylnitronate + O2 = acetaldehyde + chemical entity + H(+) + nitrite"}, {"i": "EC:1.13.12.16", "l": "\"Nitronate monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003844", "l": "1,4-alpha-glucan branching enzyme activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-112434", "l": "Formation of DSIF complex  (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46190", "l": "a carboxylate + NH4(+) => an aliphatic nitrile + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109639", "l": "Formation of the closed pre-initiation complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047016", "l": "cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity"}, {"i": "RHEA:11896", "l": "7alpha-hydroxycholesterol + NAD(+) = 7alpha-hydroxycholest-4-en-3-one + H(+) + NADH"}, {"i": "EC:1.1.1.181", "l": "\"Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19630", "l": "D-threo-isocitrate + NADP(+) => 2-oxoglutarate + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202328", "l": "Translocation of PKC theta to plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1028821", "l": "Dimerization of Phospho IRF3 or phospho IRF7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62616", "l": "a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose = a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21334", "l": "CoA + H(+) + N-acetyl-D-glucosamine => acetyl-CoA + D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66631", "l": "(2S,4S,5S)-2-amino-6-(3,4-dihydroxyphenyl)-4-hydroxy-5-(methylamino)hexanoyl-[peptidyl-carrier protein] + O2 <=> (2S,4S)-2-amino-4-[(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]-4-hydroxybutanoyl-[peptidyl-carrier protein] + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28577", "l": "H(+)(in) + sulfate(in) <=> H(+)(out) + sulfate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1878002", "l": "XYLTs transfer Xyl to core protein (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351208", "l": "Spermidine  => N-acetylated spermidine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015606", "l": "spermidine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434058", "l": "LPS binding to Toll like receptor 4 results in dimerization of the TLR4 associated with LY96 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2106625", "l": "Duplex siRNA is loaded into Argonaute (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43305", "l": "3'-phosphoadenylyl sulfate + beta-D-Gal-(1<->1')-Cer => 1-(3-O-sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16578", "l": "ADP + ATP + H(+) => P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76373", "l": "N-hydroxylation of 4-aminobiphenyl (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38928", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373073", "l": "Receptors CCR1, 2 and 8 bind CCL16 ligand (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168848", "l": "tBID binds to inactive BAK protein (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51541", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] => (S)-corytuberine + 2 H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016720", "l": "delta12-fatty acid dehydrogenase activity"}, {"i": "MetaCyc:1.14.99.33-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18949", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha,13alpha-diol"}, {"i": "EC:1.14.14.106", "l": "\"Taxane 13-alpha-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29430", "l": "(R)-carnitine(out) + 4-(trimethylamino)butanoate(in) <=> (R)-carnitine(in) + 4-(trimethylamino)butanoate(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102344", "l": "3-hydroxy-behenoyl-CoA dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429845", "l": "5' to 3' exoribonuclease hydrolyzes decapped mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707523", "l": "Hemes bind to BACH1:MAFK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047041", "l": "(S)-carnitine 3-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130151", "l": "Dimerization of DAP12 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55339", "l": "a 5'-hydroxy-3'-methoxyflavone + S-adenosyl-L-methionine <=> a 3',5'-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59895", "l": "L-2-amino-4-chloropent-4-enoate <=> chloride + H(+) + L-propargylglycine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031850", "l": "delta-type opioid receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66309", "l": "an inositol-1-phosphoceramide + GDP-alpha-D-mannose => an alpha-mannosylinositol-1-phosphoceramide + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731075", "l": "Syndecan-1 binds collagen types I, III, V (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52502", "l": "(13R)-hydroxy-(9Z,11E)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40373", "l": "3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ADP + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ATP"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015045", "l": "rubredoxin-NAD(P)+ reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-167415", "l": "G-protein alpha subunit is inactivated (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25782", "l": "3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate => H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39338", "l": "3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0099602", "l": "neurotransmitter receptor regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29059", "l": "2 H(+)(in) + H2 + ubiquinone-8 = 2 H(+)(out) + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20676", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NADP(+) <=> 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32417", "l": "(1S,4R)-isodihydrocarvone + H(+) + NADH => (1S,2S,4R)-isodihydrocarveol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46703", "l": "(R)-lipoate + GTP + H(+) <=> (R)-lipoyl-GMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015496", "l": "putrescine:ornithine antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49239", "l": "N(pros)-phospho-L-histidyl-[protein](out) + sucrose <=> L-histidyl-[protein] + sucrose 6(G)-phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871260", "l": "YAP1 binds TEAD2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35816", "l": "4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) => 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57011", "l": "5,5'-dehydrodivanillate + H(+) + NADH + O2 <=> 2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + formaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112037", "l": "Inactivation of PLC beta (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13635", "l": "ADP + gamma-L-glutamylputrescine + H(+) + phosphate => ATP + L-glutamate + putrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48738", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56496", "l": "gypsogenin + O2 + reduced [NADPH--hemoprotein reductase] = gypsogenate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201608", "l": "Caspase-mediated cleavage of alpha adducin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50978", "l": "prostaglandin D2(in) => prostaglandin D2(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12694", "l": "3,4-dihydroxypyridine + O-acetyl-L-serine => 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15117", "l": "3'-dephospho-CoA + ATP = 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine"}, {"i": "EC:2.4.2.52", "l": "\"Triphosphoribosyl-dephospho-CoA synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38631", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948757", "l": "AKT phosphorylates MKRN1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63962", "l": "abscisate(in) + ADP + H(+) + phosphate => abscisate(out) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47947", "l": "(2E)-geranyl diphosphate + H2O <=> (2E)-geranyl phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12019", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-germacrene D + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972979", "l": "POU5F1 (OCT4), NANOG bind the CDX2 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001006", "l": "RNA polymerase III type 3 promoter sequence-specific DNA binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102359", "l": "daphnetin 4-O-beta-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001792", "l": "polymeric immunoglobulin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44599", "l": "a fatty acyl-[ACP] + H2O <=> a fatty acid + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508292", "l": "SYK binds IL2RB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.96.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204434", "l": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53916", "l": "an acyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56181", "l": "8-carboxy-8-demethylriboflavin 5'-phosphate + 2 A + H2O + L-glutamate => 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 2 AH2 + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42851", "l": "8-demethyltetracenomycin C + dTDP-beta-L-rhamnose <=> 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299359", "l": "Activation of TALK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20169", "l": "H(+) + NADPH + O2 + tetradecanoyl-CoA = (11E)-tetradecenoyl-CoA + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25551", "l": "(+)-copalyl diphosphate <=> abieta-8(14),12-diene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032132", "l": "O6-alkylguanine-DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46947", "l": "(S)-2-amino-6-oxohexanoate + holo-[LYS2 peptidyl-carrier protein] + NADP(+) <=> H(+) + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507868", "l": "Aquaporins passively transport water into cells (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14899", "l": "2-hydroxy-2,3-dihydrogenistein + H2O + 2 NADP(+) => apigenin + 3 H(+) + 2 NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264865", "l": "Caspase-mediated cleavage of Lamin A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0008641", "l": "ubiquitin-like modifier activating enzyme activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30766", "l": "H2O + L-valine + NAD(+) <=> 3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-453338", "l": "PGYM b dimer:AMP complex <=> PGYM dimer, b form + 2 AMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50871", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 <=> (5,12,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047461", "l": "(+)-delta-cadinene synthase activity"}, {"i": "MetaCyc:4.6.1.11-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25273", "l": "ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate"}, {"i": "EC:6.3.2.37", "l": "\"UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18926", "l": "L-gulono-1,4-lactone + NADP(+) => D-glucurono-3,6-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679044", "l": "FKBP1A binds sirolimus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.207"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44145", "l": "acetyl-CoA + L-methionine => CoA + H(+) + N(alpha)-acetyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669240", "l": "FLNA binds PAK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050797", "l": "thymidylate synthase (FAD) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57931", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine <=> ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44032", "l": "9,10-epoxy-(12Z)-octadecenoate + H2O = 9,10-dihydroxy-(12Z)-octadecenoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046569", "l": "glyoxal oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20498", "l": "2-arylethylamine + acetyl-CoA => CoA + H(+) + N-acetyl-2-arylethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50231", "l": "FADH2 + O2 + resorcinol <=> benzene-1,2,4-triol + FAD + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61777", "l": "rebaudioside D + UDP-alpha-D-glucose => H(+) + rebaudioside M + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26139", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65758", "l": "(2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] => 2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53695", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O <=> H(+) + prostaglandin E2 + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53104", "l": "4-hydroxyestrone + S-adenosyl-L-methionine = 4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674529", "l": "AAMP binds to TBXA2R (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606273", "l": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59156", "l": "ATP + eicosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] = AMP + diphosphate + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5679266", "l": "Beclin-1 complex translocates to the ER (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009072", "l": "STAT3 phosphorylation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.15"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56018", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2) => H2O + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.97", "l": "\"Assemblin\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106244", "l": "eupatolide synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47554", "l": "deoxycholate + glycine => glycodeoxycholate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72697", "l": "Start codon recognition (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8871265", "l": "YAP1 binds TEAD4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047540", "l": "2-enoate reductase activity"}, {"i": "RHEA:10200", "l": "butanoate + NAD(+) = (2E)-2-butenoate + H(+) + NADH"}, {"i": "EC:1.3.1.31", "l": "\"2-enoate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5591052", "l": "PROCR binds Protein C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-888577", "l": "Synthesis of GABA by GAD2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043766", "l": "Sep-tRNA:Cys-tRNA synthase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120170", "l": "intraciliary transport particle B binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19409", "l": "cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH"}, {"i": "EC:1.1.1.159", "l": "\"7-alpha-hydroxysteroid dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736959", "l": "WWTR1:p-2S-SMAD2,3:SMAD4 binds SERPINE1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15673", "l": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+)"}, {"i": "EC:3.1.2.11", "l": "\"Acetoacetyl-CoA hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1299359", "l": "Activation of TALK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47231", "l": "docosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24005", "l": "butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61505", "l": "pelargonidin + UDP-alpha-D-glucose => pelargonidin 3-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41243", "l": "N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine = N-acyl-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoate (4E)-octadecasphin-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16239", "l": "[protein]-peptidylproline (omega=0) => [protein]-peptidylproline (omega=180)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429699", "l": "CERT [ER] + ceramide [ER] => CERT:ceramide [ER] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53513", "l": "(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O => (13R)-S-cysteinylglycinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-517705", "l": "p-S318,221-HuR binds mRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21018", "l": "L-aspartate + NH4(+) => H2O + L-asparagine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61176", "l": "(E)-caffeoyl-CoA + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside = CoA + H(+) + quercetin 3-O-[(6-O-[(E)-caffeoyl]-beta-D-glucosyl)-(1->2)-beta-D-glucoside]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52436", "l": "a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + an acyl-CoA = 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50964", "l": "cytidine(8) in tRNA + H(+) + H2O = NH4(+) + uridine(8) in tRNA"}, {"i": "EC:3.5.4.35", "l": "\"tRNA(cytosine(8)) deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5252001", "l": "ATP1B4 binds SNW1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601849", "l": "Defective CYP19A1 does not convert ANDST to E1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014296", "l": "RAC2 GEFs activate RAC2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416562", "l": "p190RhoGAP binds Plexin-B1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68688", "l": "CDC6 association with ORC:origin complexes mediated by MCM8 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429955", "l": "CCR4-NOT complex deadenylates mRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61307", "l": "N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose <=> H(+) + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64793", "l": "L-lysine + NADP(+) => 2 H(+) + L-1-piperideine-6-carboxylate + NADPH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64233", "l": "8 H(+) + holo-[ACP] + 8 malonyl-CoA => atrochrysone carboxyl-[ACP] + 8 CO2 + 8 CoA + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52482", "l": "(3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51859", "l": "(E)-hexadec-2-enoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (2E)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22705", "l": "2 H2O + ricinine => 4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061922", "l": "histone propionyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047843", "l": "dehydrogluconate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3785768", "l": "MRN complex binds DNA double strand breaks (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389481", "l": "Orexin 1 receptor can bind orexin-A neuropeptide (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867613", "l": "PICALM binds R-SNAREs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52929", "l": "cyclic di-3',5'-guanylate + 2 H2O => 2 GMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31069", "l": "Delta(1)-piperideine-2-carboxylate + H2O => 6-amino-2-oxohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11194", "l": "a (2R)-2-hydroxycarboxylate + a halide anion + H(+) => an (S)-2-haloacid + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12183", "l": "anthranilate + S-adenosyl-L-methionine <=> H(+) + N-methylanthranilate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035403", "l": "histone kinase activity (H3-T6 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30873", "l": "2-deoxy-D-ribose 5-phosphate + ADP + H(+) => 2-deoxy-D-ribose + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632393", "l": "TP63/TP53 bind the DDIT4 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55877", "l": "apo-[aequorin] + coelenterazine => apo-[aequorin]--coelenterazine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42549", "l": "uridine(746) in 23S rRNA => pseudouridine(746) in 23S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31849", "l": "shionone => (S)-2,3-epoxysqualene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12291", "l": "an alpha-L-fucoside + H2O <=> an alcohol + L-fucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102538", "l": "UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase activity"}, {"i": "MetaCyc:RXN-14767"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701810", "l": "MECP2 binds the STAT5A gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687088", "l": "PKA phosphorylates MAPKAPK5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044669", "l": "sodium:galactoside symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "71.045893708194711", "identifiers": [{"i": "GO:0008171", "l": "O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804099", "l": "HMGB1 binds LTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203774", "l": "Interaction of Csk with PAG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37572", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine => 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31525", "l": "3 CO2 + ethene + H2O => 2-oxoglutarate + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102003", "l": "Delta8-sphingolipid desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32527", "l": "N,N'-diacetylchitobiose + phosphate = N-acetyl-alpha-D-glucosamine 1-phosphate + N-acetyl-D-glucosamine"}, {"i": "EC:2.4.1.280", "l": "\"N,N'-diacetylchitobiose phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45875", "l": "15-hydroxypentadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(14-hydroxytetradecyl)-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5195402", "l": "CDK1 phosphorylates LPIN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37239", "l": "2',3'-cyclic UMP + H2O = H(+) + uridine 2'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944257", "l": "Association of procollagen type XXIV (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47282", "l": "4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29737", "l": "butanal + FMN + 2 H(+) + H2O + sulfite => butane-1-sulfonate + FMNH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50935", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 <=> (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209973", "l": "Tyrosine is diiodinated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874797", "l": "EGFR gene expression is stimulated by TFAP2C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047671", "l": "anthranilate adenylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39407", "l": "3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36540", "l": "hexadecanoyl-CoA + sphinganine => CoA + H(+) + N-hexadecanoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56024", "l": "H2O + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2) = beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60182", "l": "ADP + D-fructose(in) + H(+) + phosphate => ATP + D-fructose(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63618", "l": "H(+) + prunetin-C(8)-beta-D-glucuronide + UDP => prunetin + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2038387", "l": "Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47379", "l": "(25R)-3beta,26-dihydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta-hydroxycholest-5-en-7-one-26-al + 2 H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18770", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate => 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55225", "l": "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043221", "l": "SMC family protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35577", "l": "(1'S,5'R)-5'-hydroxyaverantin + H2O + oxidized [NADPH--hemoprotein reductase] => (1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11142", "l": "D-mannose 6-phosphate => alpha-D-mannose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15071", "l": "chlorophyllide a + H2O => 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54592", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0008553", "l": "P-type proton-exporting transporter activity"}, {"i": "RHEA:20852", "l": "ATP + H(+)(in) + H2O = ADP + 2 H(+)(out) + phosphate"}, {"i": "EC:7.1.2.1", "l": "\"P-type H(+)-exporting transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61831", "l": "stigmasterol + UDP-alpha-D-glucose <=> H(+) + stigmasteryl 3-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64900", "l": "H2O + UTP = H(+) + phosphate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41525", "l": "5 H(+) + 5 malonyl-CoA => 5 CO2 + 5 CoA + H2O + naphthalene-1,3,6,8-tetrol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31803", "l": "H2O + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose = 2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H(+) + UDP"}, {"i": "EC:3.6.1.57", "l": "\"UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45933", "l": "2-methylhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(3-methyl-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43890", "l": "[sulfur carrier]-SH + [sulfur-carrier protein]-L-cysteine => [sulfur carrier]-H + [sulfur-carrier protein]-S-sulfanyl-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193722", "l": "TetraHCA is translocated from the mitochondrial matrix to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061593", "l": "sulfoquinovose isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45267", "l": "(9Z,12Z)-octadecadienoate(out) <=> (9Z,12Z)-octadecadienoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53463", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9650165", "l": "ASIC trimers bind H+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28137", "l": "(2S)-hesperidin + H2O <=> (2S)-hesperetin + rutinose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001097", "l": "TFIIH-class transcription factor complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017817", "l": "Gamma-secretase cleaves YBX1:NOTCH3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8931981", "l": "RUNX1 binds ESR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035988", "l": "Defective HLCS does not biotinylate PC:Mn2+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702578", "l": "semaxanib-resistant FLT3 mutants don't bind semaxanib<br> (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30847", "l": "FAD + glutaryl-CoA + 2 H(+) = (2E)-butenoyl-CoA + CO2 + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937807", "l": "SRC phosphorylates RUNX3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5357445", "l": "PAK1-3 dimer disassociates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47969", "l": "ganglioside GM2 + H2O => ganglioside GM3 + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43139", "l": "guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38599", "l": "NADP(+) + nicotinate = nicotinamide + nicotinate-adenine dinucleotide phosphate"}, {"i": "EC:2.4.99.20", "l": "\"2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080061", "l": "indole-3-acetonitrile nitrilase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23360", "l": "L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72143", "l": "Lariat Formation and 5'-Splice Site Cleavage (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42651", "l": "(2,5-ethylene furandicarboxylate)(n) + 2 H2O <=> (2,5-ethylene furandicarboxylate)(n-1) + 2,5-dicarboxyfuran + ethylene glycol + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10182", "l": "(6S)-5,6,7,8-tetrahydrofolate + CO2 + H(+) + NADPH => (6S)-10-formyltetrahydrofolate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008797", "l": "aspartate ammonia-lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73577", "l": "CAD hexamer transforms L-Gln to CAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198813", "l": "GSTO dimers reduce DeHA to AscH- (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.22", "l": "\"Pectate trisaccharide-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40452", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9733969", "l": "Bile salts dissociate from FABP6 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2509827", "l": "ITPA hydrolyses ITP to IMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23321", "l": "D-tryptophan + malonyl-CoA => CoA + H(+) + N(2)-malonyl-D-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52898", "l": "2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate => 2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62234", "l": "a thymidine dimer in DNA => a thymidine(6-4)thymidine in DNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374173", "l": "AGT(34-41) binds to AGTR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169394", "l": "ISGylation of IRF3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23594", "l": "D-glyceraldehyde + H(+) + NADPH => glycerol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106251", "l": "N4-acetylcytidine amidohydrolase activity"}, {"i": "RHEA:62932", "l": "H2O + N(4)-acetylcytidine = acetate + cytidine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46411", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43930", "l": "progesterone => pregn-5-ene-3,20-dione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.21"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18560", "l": "1-O-alkyl-sn-glycero-3-phosphate + acetyl-CoA <=> 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9680443", "l": "ROCK1,2 bind ROCKi (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376419", "l": "Formation of NR-MED1 Coactivator Complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676229", "l": "WIPIs bind PI3P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690873", "l": "ACO1 binds 4Fe-4S (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56419", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate <=> alpha-D-glucose 1-phosphate + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797100", "l": "CCNK binds CDK13 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58551", "l": "2 L-ascorbate + N-(9Z,12Z,15Z)-octadecatrienoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44359", "l": "nogalaviketone <=> methyl nogalonate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034008", "l": "R-linalool synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66659", "l": "Cu(2+)(out) + L-ascorbate(in) <=> Cu(+)(out) + H(+) + monodehydro-L-ascorbate radical(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17990", "l": "ATP + L-seryl-[protein] => ADP + H(+) + O-phospho-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30540", "l": "(R)-carnitinyl-CoA => (S)-carnitinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27760", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + CO2 + NADH + NH4(+) => (6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28182", "l": "(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate = (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate"}, {"i": "EC:5.3.3.17", "l": "\"Trans-2,3-dihydro-3-hydroxyanthranilate isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429815", "l": "Formation Of Bloc-1 Complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37343", "l": "adenosine 2'-phosphate + H2O = adenosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59559", "l": "H2O + N,N'-diacetylchitobiono-1,5-lactone <=> H(+) + N,N'-diacetylchitobionate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66279", "l": "tigogenin + UDP-alpha-D-glucose <=> H(+) + tigogenin 3-O-beta-D-glucopyranoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3209165", "l": "ID1 sequesters ETS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867613", "l": "PICALM binds R-SNAREs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.4", "l": "\"Exodeoxyribonuclease (phage SP3-induced)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62756", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21285", "l": "all-trans-retinol + NAD(+) => all-trans-retinal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44412", "l": "3-demethylubiquinol-10 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177923", "l": "Sustained activation of SRC kinase by SHP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10540", "l": "7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde"}, {"i": "EC:4.1.2.25", "l": "\"Dihydroneopterin aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51575", "l": "(25S)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25S)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40455", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA = (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050623", "l": "berberine reductase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990583", "l": "phospholipase D activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52779", "l": "2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> camalexin + CO2 + 2 H(+) + 4 H2O + hydrogen cyanide + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66824", "l": "2 ATP + 2 cob(II)inamide + 2 H2O + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)inamide + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16985", "l": "3-oxoadipate + NADP(+) = H(+) + maleylacetate + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004992", "l": "platelet activating factor receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229132", "l": "AP4 binds APP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9650473", "l": "SERPING1 is secreted (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015095", "l": "magnesium ion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11509", "l": "2-oxoglutarate + L-aspartyl-[protein] + O2 => 3-hydroxy-L-aspartyl-[protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41432", "l": "3-methyl-L-tyrosine + H2O2 = 5-hydroxy-3-methyl-L-tyrosine + H2O"}, {"i": "EC:1.11.2.5", "l": "\"3-methyl-L-tyrosine peroxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662781", "l": "CD163 gene produces CD163 protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65533", "l": "2-methylbutan-1-ol + hexanoyl-CoA => 2-methylbutyl hexanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48019", "l": "4-methyl-5-nitrocatechol + NADH + O2 <=> 2-hydroxy-5-methylquinone + H(+) + H2O + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707690", "l": "BACH1 binds MAFK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59465", "l": "NADP(+) + octadecan-1-ol => H(+) + NADPH + octadecanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211962", "l": "CYP4F11 16-hydroxylates 3OH-PALM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12467", "l": "myo-inositol + UDP-alpha-D-galactose <=> alpha-D-galactosyl-(1->3)-1D-myo-inositol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58949", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine => 4-O-([3-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649856", "l": "Oxidative damage to the AP site (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856808", "l": "Recruitment of AP-2 complex and clathrin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662606", "l": "MT3 binds zinc (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018758", "l": "RHOH binds effectors at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193964", "l": "CYP21A2 21-hydroxylates PROG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39378", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA <=> (2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693125", "l": "RHOF binds effectors at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21944", "l": "ATP + D-cellobiose = 6-phospho-beta-D-glucosyl-(1->4)-D-glucose + ADP + H(+)"}, {"i": "EC:2.7.1.85", "l": "\"Beta-glucoside kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.18", "l": "\"Methionyl aminopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24032", "l": "sucrose = 6-O-alpha-D-glucopyranosyl-D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444572", "l": "Zinc is an agonist of GPR39 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247842", "l": "Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50437", "l": "prostaglandin H1 => prostaglandin E1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15965", "l": "1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120108", "l": "DNA-3'-diphospho-5'-guanosine diphosphatase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67146", "l": "(1R,2R)-12-hydroxyjasmonate + CO2 + succinate => 2-oxoglutarate + jasmonate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36473", "l": "3,4,5-trihydroxybenzoate(in) + H(+)(in) => 3,4,5-trihydroxybenzoate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706293", "l": "Active FLT3 binds to CBL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22523", "l": "all-trans-retinal + H2O + O2 <=> all-trans-retinoate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015313", "l": "fluconazole:proton antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45263", "l": "tetracosanoate(out) <=> tetracosanoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36228", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53265", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 2beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36169", "l": "a 2'-deoxyribonucleoside + phosphate => a 2'-deoxyribonucleoside 5'-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018111", "l": "methionine racemase activity"}, {"i": "RHEA:12492", "l": "L-methionine = D-methionine"}, {"i": "EC:5.1.1.2", "l": "\"Methionine racemase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16632", "l": "(S)-malyl-CoA <=> acetyl-CoA + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12924", "l": "glycine + H(+) + succinyl-CoA <=> 5-aminolevulinate + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41083", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168885", "l": "Haptoglobin binds Hemoglobin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66093", "l": "3-phenylpyruvate + L-kynurenine => H2O + kynurenate + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296045", "l": "Activation of Potassium transport channels (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0005248", "l": "voltage-gated sodium channel activity"}, {"i": "REACT:R-HSA-5576895", "l": "SCNAs:SNCBs transport Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44762", "l": "6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-nonaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25942", "l": "8-chloroquinolin-2(1H)-one + AH2 => 8-chloroquinoline + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47145", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807585", "l": "BPI binds LPS on the bacterial surface (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209536", "l": "IkB is ubiquitinated and degraded (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50698", "l": "calcidiol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => calciol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169402", "l": "ISGylation of E2 conjugating enzymes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34727", "l": "H2O + N-acyl-15-methylhexadecasphinganine = 15-methylhexadecasphinganine + a carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36803", "l": "2-hydroxy-2,3-dihydrogenistein = genistein + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0034987", "l": "immunoglobulin receptor binding"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0097644", "l": "calcitonin family binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868230", "l": "SNX9 recruits components of the actin polymerizing machinery (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684234", "l": "Encapsidation of SARS coronavirus genomic RNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399946", "l": "Recruitment and activation of Cdk5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204773", "l": "Interaction of Tie2 and Grb7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74885", "l": "GUCYs converts GTP to cGMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109700", "l": "AKT2 binds PIP3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016216", "l": "isopenicillin-N synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798743", "l": "Exocytosis of secretory granule membrane proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66165", "l": "butanoyl-CoA + serotonin => CoA + H(+) + N-butanoylserotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56387", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 <=> (5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102716", "l": "gibberellin A28,oxoglutarate:oxygen oxidoreductase activity"}, {"i": "MetaCyc:RXN-6547"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047918", "l": "GDP-mannose 3,5-epimerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693198", "l": "RHOD binds effectors at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39594", "l": "(3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA <=> (2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30622", "l": "2 A + all-trans-zeta-carotene <=> 2 AH2 + all-trans-lycopene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088307", "l": "FOXM1 binds CCNB1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637792", "l": "PLC-gamma 1 binds to p-EGFRvIII mutant (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56589", "l": "a monosubstituted aliphatic (S)-hydroxynitrile => an aldehyde + hydrogen cyanide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53763", "l": "allocholate + deoxycholoyl-CoA <=> allocholoyl-CoA + deoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28815", "l": "4-hydroxybenzoate(in) + H(+)(out) = 4-hydroxybenzoate(out) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9640167", "l": "RRAGA,B exchanges GDP for GTP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1222491", "l": "Lactoferrin scavenges iron ions (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674022", "l": "BRAP autoubiquitinates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66728", "l": "ATP + H2O + N-acetyl-L-aspartyl-L-glutamate(in) = ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848726", "l": "PTK6 phosphorylates BCAR1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47817", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-diphosphate + NADPH + O2 => 9-ribosyl-trans-zeatin 5'-diphosphate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58607", "l": "FAD + 2 H(+) + NADH + O2 <=> FADH2-C4alpha-hydroperoxide + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12435", "l": "L-alanyl-tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine <=> H(+) + tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-N(6)-(L-alanyl)-L-lysyl-D-alanyl-D-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26345", "l": "L-galactonate + NADP(+) = aldehydo-D-galacturonate + H(+) + NADPH"}, {"i": "EC:1.1.1.365", "l": "\"D-galacturonate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429730", "l": "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15340", "l": "H2O + phenylglyoxylyl-CoA <=> CoA + H(+) + phenylglyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17710", "l": "4-hydroxybenzoate + all-trans-nonaprenyl diphosphate => 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653957", "l": "Rag dimer formation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11072", "l": "anthranilate + 3 H(+) + NADPH + O2 = catechol + CO2 + NADP(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41833", "l": "(2E)-hexenoyl-[ACP] + H(+) + NADPH => hexanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404193", "l": "IGF1R phosphorylates SHC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "58.35160156595974", "identifiers": [{"i": "GO:0016798", "l": "hydrolase activity, acting on glycosyl bonds"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29099", "l": "a menaquinone + 5 H(+)(in) + NADH = a menaquinol + 4 H(+)(out) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28158", "l": "alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45456", "l": "H2O + N-dodecanoylethanolamine = dodecanoate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60769", "l": "3 2-oxoglutarate + gibberellin A12 + 3 O2 => 3 CO2 + gibberellin A25 + H(+) + H2O + 3 succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002112", "l": "interleukin-33 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42011", "l": "5alpha-pregnan-20beta-ol-3-one + NAD(+) <=> 5alpha-pregnane-3,20-dione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57981", "l": "(20S)-protopanaxatriol + UDP-alpha-D-glucose => (20S)-ginsenoside F1 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.99.-", "l": "\"Transferring other nitrogenous groups\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17827", "l": "ADP + D-glucose 6-phosphate + H(+) => ATP + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43055", "l": "3-(methylsulfanyl)propanoate + ATP + CoA <=> 3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036289", "l": "Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103089", "l": "methylthiohexylmalate isomerase activity"}, {"i": "MetaCyc:RXNQT-4173"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864105", "l": "PTPN18 binds ERBB2:EGFR heterodimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58676", "l": "NADPH + O2 + rifamycin SV = H2O + NADP(+) + rifamycin SV para-naphthoquinone carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981814", "l": "GalNAc alpha-2,6-sialyltransferase II can add a sialic acid to the T antigen at the alpha 6 position (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51852", "l": "(9Z,12Z)-octadecadienoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z,12Z)-octadecadienoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851018", "l": "BTN2A1 binds DC-SIGN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191072", "l": "Synthesis of Cx43 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54496", "l": "ent-copalyl diphosphate = diphosphate + ent-atiserene"}, {"i": "EC:4.2.3.185", "l": "\"Ent-atiserene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705738", "l": "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15455", "l": "H(+) + N,N-dimethylglycine + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + sarcosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-877187", "l": "P2X7 mediates loss of intracellular K+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033039", "l": "salty taste receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111930", "l": "Adenylate cyclase produces cAMP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56471", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 bromide + 3 FADH2 + 3 O2 <=> (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 FAD + 6 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10420", "l": "pyruvate + taurine = L-alanine + sulfoacetaldehyde"}, {"i": "RHEA:58056", "l": "hypotaurine + pyruvate = 2-sulfinoacetaldehyde + L-alanine"}, {"i": "EC:2.6.1.77", "l": "\"Taurine--pyruvate aminotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18669", "l": "adenosine + H2O = adenine + D-ribose"}, {"i": "EC:3.2.2.7", "l": "\"Adenosine nucleosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41957", "l": "2',3'-cyclic CMP + H2O => cytidine 2'-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44372", "l": "Cr(6+) + 2 NADH + O2 = Cr(3+) + 2 H(+) + 2 NAD(+) + superoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27428", "l": "(2E,6E)-farnesyl diphosphate <=> (E)-beta-farnesene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29453", "l": "H2 + phosphate => H2O + phosphonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31154", "l": "H2O + L-selenocystathionine <=> 2-oxobutanoate + L-selenocysteine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432143", "l": "PECAM-1 binds PP2A (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030107", "l": "HLA-A specific inhibitory MHC class I receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374663", "l": "DCC interaction with Ezrin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8934465", "l": "SHC1 binds PTPN12 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34042", "l": "2-oxoglutarate + neamine <=> 6'-oxoparomamine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62092", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-diphosphate + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443926", "l": "Thrombopoietin binds the thrombopoietin receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12022", "l": "a monocarboxylate + NH4(+) => a monocarboxylic acid amide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39565", "l": "(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+) => (2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237160", "l": "MTA is cleaved and phosphorylated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11451", "l": "NAD(+) + pregnan-21-ol <=> H(+) + NADH + pregnan-21-al"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38069", "l": "1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806957", "l": "MET receptor dimerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40305", "l": "(2E)-dodecenedioyl-CoA + AH2 => A + dodecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801195", "l": "STEAP3 binds BNIP3L (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30261", "l": "2 a menaquinone + 2 H2O => 2 a menaquinol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22933", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052764", "l": "exo-oligoalginate lyase activity"}, {"i": "EC:4.2.2.26", "l": "\"Oligo-alginate lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62735", "l": "(+)-isomalbrancheamide B + bromide + FAD + 2 H(+) <=> (+)-isomalbrancheamide D + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13468", "l": "(S)-2,3-diaminopropanoate + oxalyl-CoA <=> CoA + N(3)-oxalyl-L-2,3-diaminopropanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39475", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA = (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19293", "l": "a monoacylglycerol + ATP = ADP + H(+) + monoacyl-sn-glycero-3-phosphate"}, {"i": "EC:2.7.1.94", "l": "\"Acylglycerol kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15466", "l": "ATP + sphinganine => ADP + H(+) + sphinganine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390438", "l": "FAR2 reduces PalmCoA to HXOL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5668714", "l": "RAC1:GTP binds NOX1 complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49292", "l": "D-cellobiose(out) + N(pros)-phospho-L-histidyl-[protein] = 6-phospho-beta-D-glucosyl-(1->4)-D-glucose(in) + L-histidyl-[protein]"}, {"i": "EC:2.7.1.205", "l": "\"Protein-N(pi)-phosphohistidine--D-cellobiose phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13115", "l": "H(+) + N-hydroxy-2-acetamidofluorene + NADPH => 2-acetamidofluorene + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13410", "l": "7-aminomethyl-7-carbaguanine + 2 NADP(+) => 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65174", "l": "(3Z,5E)-dodecadienoate + CoA + H(+) => (3Z,5E)-dodecadienoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981809", "l": "ST6GALNAC3/4 can add a sialic acid to the sialyl T antigen to form the disialyl T antigen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430096", "l": "GP1b-IX-V binds filamin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853496", "l": "SCF:FBXL7 binds AURKA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65424", "l": "AMP(in) + NAD(+)(out) = AMP(out) + NAD(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878193", "l": "RUNX3 binds the JAG1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59530", "l": "CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein] => hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964759", "l": "Alternative endo-mannosidase I route (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14369", "l": "2-phosphoglycolate + H2O = glycolate + phosphate"}, {"i": "EC:3.1.3.18", "l": "\"Phosphoglycolate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936058", "l": "miR-675 binds RUNX1 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29796", "l": "ATP(in) + H2O(in) + Zn(2+)(out) => ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.10", "l": "\"Steroid C-25 hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218847", "l": "PAK2 binds NCK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2186780", "l": "Degradation of Ub-SMAD7 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050513", "l": "glycoprotein 2-beta-D-xylosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62600", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = 5-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802935", "l": "MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71783", "l": "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36355", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine"}, {"i": "EC:2.5.1.114", "l": "\"tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2428922", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18980", "l": "a quinone + sn-glycerol 3-phosphate <=> a quinol + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874849", "l": "CREBRF binds CREB3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24136", "l": "3'-phosphoadenylyl sulfate + a primary amine = a sulfamate + adenosine 3',5'-bisphosphate + 2 H(+)"}, {"i": "EC:2.8.2.3", "l": "\"Amine sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13318", "l": "(2R,3R)-tartrate + H(+) => (R)-glycerate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36660", "l": "carbamoyl phosphate + descarbamoylnovobiocin => novobiocin + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168140", "l": "Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2514790", "l": "Elastin degradation by MMP14 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30612", "l": "A + all-trans-zeta-carotene => AH2 + all-trans-neurosporene"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043792", "l": "enamidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59871", "l": "4-(2,4-dichlorophenoxy)butanoate + ATP + L-glutamine <=> 4-(2,4-dichlorophenoxy)butanoyl-L-glutamine + AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1222376", "l": "NOX2 generates superoxide from oxygen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371537", "l": "DBC1 binds SIRT1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50341", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + testosterone => 1alpha-hydroxytestosterone + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687284", "l": "DMBT1 binds SFTPD 12mer, SFTPAs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13633", "l": "ATP + L-glutamate + putrescine = ADP + gamma-L-glutamylputrescine + H(+) + phosphate"}, {"i": "EC:6.3.1.11", "l": "\"Glutamate--putrescine ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60143", "l": "dodecanoyl-CoA + H(+) + malonyl-CoA <=> 3-oxotetradecanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19758", "l": "(3R)-3-hydroxy-L-aspartate => NH4(+) + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038021", "l": "leptin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32129", "l": "cis-4-hydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + L-proline + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026771", "l": "DPEP hydrolyses MCTR2 to MCTR3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35673", "l": "(1'S,5'S)-averufin + H2O => (S)-5'-oxoaverantin + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20672", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NAD(+) <=> 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12959", "l": "acetate + an aliphatic alcohol + H(+) => an acetyl ester + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035484", "l": "adenine/adenine mispair binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374665", "l": "DCC interaction with SIAH1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57061", "l": "2''-O-acetyl-ADP-D-ribose + H2O => acetate + ADP-D-ribose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426158", "l": "SREBP1A,1C binds the GPAM promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32804", "l": "ATP + H2O + urea(out) => ADP + H(+) + phosphate + urea(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2395517", "l": "NADPH transfers electrons to FDXR (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52381", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008568", "l": "microtubule-severing ATPase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57975", "l": "8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448744", "l": "IL20RA binds IL20RB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20772", "l": "2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-ribitylamino)uracil + riboflavin"}, {"i": "EC:2.5.1.9", "l": "\"Riboflavin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5660665", "l": "Caspase-8 binds MALT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20636", "l": "a (3R)-hydroxyacyl-[ACP] + L-ornithine <=> a lyso-ornithine lipid + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8941895", "l": "Formation of CDK4/6:CCND complexes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10458", "l": "1-O-acetylmaltose + CoA => acetyl-CoA + D-maltose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37965", "l": "D-galactose + H(+) + NADH => galactitol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47382", "l": "(25R)-3beta-hydroxycholest-5-en-7-one-26-oate + H2O + 2 oxidized [adrenodoxin] => (25R)-3beta-hydroxycholest-5-en-7-one-26-al + H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48058", "l": "beta-D-glucosylceramide + D-galactose => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38764", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3791155", "l": "Laminin-322 degradation by MMP14 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18278", "l": "a thiol + S-adenosyl-L-methionine => a methyl thioether + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578965", "l": "TNRC6A binds AGO2:miRNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51213", "l": "(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) => 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65156", "l": "2-oxoglutarate + O2 + preaustinoid A2 = CO2 + H2O + preaustinoid A3 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34604", "l": "15-methylhexadecasphinganine + a fatty acyl-CoA => CoA + H(+) + N-acyl-15-methylhexadecasphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784959", "l": "BPHL hydrolyses VACV to ACV (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47068", "l": "4alpha-formyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 = 4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186785", "l": "PDGF-AA clevage by Furin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33172", "l": "D-maltose(in) => D-maltose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25452", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + germacrene A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66700", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + ATP + CoA = (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36054", "l": "beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O <=> 2 beta-L-arabinofuranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604763", "l": "Autocatalytic activation of MMP7 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015322", "l": "secondary active oligopeptide transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5339535", "l": "GLTPD1 transports C1P from plasma membrane to Golgi membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41293", "l": "dodecanoate + sphing-4-enine => H2O + N-dodecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47399", "l": "H2O + octadecanoate ester <=> an aliphatic alcohol + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.26"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051509", "l": "tomatidine UDP-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65624", "l": "hexadecanoyl-CoA + sphinga-(4E,8Z)-dienine = CoA + H(+) + N-hexadecanoylsphinga-(4E,8Z)-dienine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102598", "l": "3alpha-hydroxy-ent-sandaracopimardiene 7-beta-monooxygenase activity"}, {"i": "MetaCyc:RXN-15382"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36487", "l": "agmatine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + N(1)-aminopropylagmatine + S-methyl-5'-thioadenosine"}, {"i": "EC:2.5.1.104", "l": "\"N(1)-aminopropylagmatine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56179", "l": "8-demethyl-8-formylriboflavin 5'-phosphate + A + H2O <=> 8-carboxy-8-demethylriboflavin 5'-phosphate + AH2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13698", "l": "ATP + D-ribose => ADP + D-ribose 5-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32076", "l": "geranylgeranyl diphosphate + H2O => (13E)-labda-7,13-dien-15-ol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012835", "l": "GDIs block activation of RHOA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-481007", "l": "Exocytosis of platelet alpha granule contents (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30771", "l": "guanosine + H2O = D-ribose + guanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34916", "l": "D-galactose(in) => D-galactose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193646", "l": "NGF binding to p75NTR inactivates RHOA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44323", "l": "1-decanoylglycerol + H2O <=> decanoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008657", "l": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5333678", "l": "CPNEs bind PL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66355", "l": "(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + NAD(+) <=> (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050454", "l": "coenzyme F420 hydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9649108", "l": "HTR3A pentamer binds 5HT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052589", "l": "malate dehydrogenase (menaquinone) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76500", "l": "TBXAS1 isomerises PGH2 to TXA2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51390", "l": "CoA + H(+) + N-acetyl-dopamine => acetyl-CoA + dopamine"}]}
{"type": "biolink:MolecularActivity", "ic": "68.86768025975131", "identifiers": [{"i": "GO:0016878", "l": "acid-thiol ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25218", "l": "acetyl-CoA + serotonin => CoA + H(+) + N-acetylserotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23733", "l": "(R)-5-diphosphomevalonate + ATP => ADP + CO2 + isopentenyl diphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60647", "l": "3'-phosphoadenylyl sulfate + 3alpha-hydroxy-5alpha-androstan-17-one <=> 3alpha-sulfooxy-5alpha-androstan-17-one + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.30", "l": "\"1,3-beta-oligoglucan phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19187", "l": "2-hydroxyglutarate + CoA + H(+) => glyoxylate + H2O + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36278", "l": "H(+) + NADPH + O2 + theophylline <=> 3-methylxanthine + formaldehyde + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40879", "l": "2 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34783", "l": "a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44850", "l": "CoA + O-(9Z)-tetradecenoyl-(R)-carnitine => (9Z)-tetradecenoyl-CoA + (R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49669", "l": "H(+) + NADH + O2 + protodeoxyviolaceinate => deoxyviolaceinate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034482", "l": "chondroitin 2-O-sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55122", "l": "(3R)-hydroxy-4-methylhexanoyl-[ACP] + NADP(+) => 4-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362549", "l": "Hh-Np traffics to the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592278", "l": "Autocatalytic activation of proMMP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "80.661393760018115", "identifiers": [{"i": "GO:0005355", "l": "glucose transmembrane transporter activity"}, {"i": "REACT:R-HSA-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Homo sapiens)"}, {"i": "REACT:R-HSA-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28666", "l": "H2O + melibiose <=> alpha-D-galactose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49809", "l": "a quinone + butan-1-ol => a quinol + butanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961846", "l": "CCNE1 gene transcription is stimulated by E2F1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37206", "l": "(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate <=> 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47181", "l": "(25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+) => (25R)-7alpha,26-dihydroxycholest-4-en-3-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709852", "l": "MAVS:TOMM70 recruits HSP90:TBK1:IRF3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41192", "l": "1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391934", "l": "DP2 receptor can bind PGD2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44128", "l": "(9E)-octadecenoyl-CoA + hexadecan-1-ol = CoA + hexadecanyl (9E)-octadecenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008779", "l": "acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21060", "l": "3,4-dichloroaniline + malonyl-CoA = CoA + N-(3,4-dichlorophenyl)malonamate"}, {"i": "EC:2.3.1.114", "l": "\"3,4-dichloroaniline N-malonyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0016797", "l": "exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters"}, {"i": "EC:3.1.16.-", "l": "\"Exonucleases active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10010", "l": "[protein]-disulfide + an alcohol + H2O => [protein]-dithiol + a hydroperoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34677", "l": "CMP-N,N-diacetyllegionaminate + diphosphate => CTP + N,N-diacetyllegionaminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58206", "l": "dihydroalstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43640", "l": "dodecanoyl-CoA + H(+) + malonyl-[ACP] = 3-oxotetradecanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42494", "l": "3'-N-debenzoyltaxol + A + H2O => 3'-N-debenzoyl-2'-deoxytaxol + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11181", "l": "ATP + L-asparagine + tRNA(Asn) => AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39998", "l": "an N-acylethanolamine + H2O <=> a fatty acid + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27525", "l": "2,5-dihydroxypyridine + O2 <=> H(+) + N-formylmaleamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110319", "l": "Elongation by POLH (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56308", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] = 1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.19.54", "l": "\"1,2-dehydroreticuline synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.23", "l": "\"DNA-formamidopyrimidine glycosylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46129", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 4beta-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018554", "l": "1,2-dihydroxynaphthalene dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53192", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63892", "l": "ATP + H2O + L-tryptophan = AMP + D-tryptophan + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209298", "l": "BSK is phosphorylated and activated by phosphorylated HEP kinase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29193", "l": "iminosuccinate + menaquinol-8 => L-aspartate + menaquinone-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64452", "l": "L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-methionine = 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.371", "l": "\"[Histone H3]-lysine(27) N-dimethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32255", "l": "meso-2,6-diaminoheptanedioate + NADP(+) = (S)-2,3,4,5-tetrahydrodipicolinate + 2 H(+) + NADPH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19457", "l": "2-nitrophenol + 2 H(+) + 2 NADPH + O2 = catechol + H2O + 2 NADP(+) + nitrite"}, {"i": "EC:1.14.13.31", "l": "\"2-nitrophenol 2-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374669", "l": "L1 binds NRP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375133", "l": "Basigin binds Mannose-carrying cell recognition molecules (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55370", "l": "(3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine => (R)-carnitine + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102463", "l": "quercetin 3-gentiobioside 7-O-rhamnosyltransferase activity"}, {"i": "MetaCyc:RXN-14012"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37436", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphate => a 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103056", "l": "gibberellin A53, 2-oxoglutarate:oxygen oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51336", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = 8-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31816", "l": "(2E,6E)-farnesyl diphosphate => (+)-beta-caryophyllene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638004", "l": "RP2 binds ARL3:GTP:UNC119B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416358", "l": "G alpha (q) inhibits PI3K alpha (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21608", "l": "isoliquiritigenin + S-adenosyl-L-methionine = 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.154", "l": "\"Isoliquiritigenin 2'-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46526", "l": "(5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (11Z,14Z)-eicosadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72124", "l": "Formation of the Spliceosomal A Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42589", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23050", "l": "(R)-2-hydroxyglutarate + acetoacetate => (S)-3-hydroxybutanoate + 2-oxoglutarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694495", "l": "RTC binds SARS-CoV-2 genomic RNA complement (minus strand) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928641", "l": "PAK binds RAC and bPIX (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60217", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008271", "l": "CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189439", "l": "ALAD condenses 2 dALAs to form PBG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666001", "l": "Profilin:G-actin binds MKL1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781905", "l": "ZRANB1 binds APC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49361", "l": "2',2'-dihydroxy-2-oxospirilloxanthin => 2,2'-dioxospirilloxanthin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030762", "l": "tetrahydrocolumbamine 2-O-methyltransferase activity"}, {"i": "MetaCyc:2.1.1.89-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22547", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O <=> a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39401", "l": "(2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29425", "l": "ADP + H(+) + triphosphate => ATP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23131", "l": "4-hydroxybutanoate + ATP + CoA <=> 4-hydroxybutanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035243", "l": "protein-arginine omega-N symmetric methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902314", "l": "hydroquinone binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0015603", "l": "iron chelate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112604", "l": "Phosphorylated STATs are released (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112342", "l": "Inactivation of MAP2K1 by CDK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672969", "l": "Phosphorylation of RAF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51932", "l": "2 [Fe(III)-cytochrome c3] + hydrogen sulfide + sulfite = 2 [Fe(II)-cytochrome c3] + thiosulfate"}, {"i": "EC:1.8.2.5", "l": "\"Thiosulfate reductase (cytochrome)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802834", "l": "RAS GTPase mutants don't hydrolyze GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.1.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932599", "l": "CALB1 binds 4xCa2+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606887", "l": "p-CD19:VAV binds PI3K and GRB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621370", "l": "SYK autophosphorylates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034292", "l": "pinholin activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25799", "l": "2-oxoglutarate + L-methionine <=> 4-methylsulfanyl-2-oxobutanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46175", "l": "ATP + butanoate + CoA <=> AMP + butanoyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018766", "l": "RHOU binds effectors at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0035184", "l": "histone threonine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2002428", "l": "Removal of fibrillar collagen N-propeptides (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046875", "l": "ephrin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5690152", "l": "USP5 cleaves polyubiquitin (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38782", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52820", "l": "L-serine + succinyl-CoA = CoA + O-succinyl-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11417", "l": "2 1-O-galloyl-beta-D-glucose => 1,6-bis-O-galloyl-beta-D-glucose + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5263633", "l": "DYSF, CAV3 and TRIM72 bind (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57079", "l": "3-oxoisoapionate 4-phosphate + H2O <=> 3-phosphoglycerate + glycolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58341", "l": "beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O => chenodeoxycholate + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11297", "l": "2,5-dioxopentanoate + H2O + NADP(+) => 2-oxoglutarate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19775", "l": "D-glyceraldehyde 3-phosphate + H(+) + NADPH => NADP(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12204", "l": "dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = 3alpha-hydroxy-3,5-dihydromonacolin L carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199112", "l": "CRTAM binds to NECL2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42414", "l": "ADP + cyclic (2R)-2,3-bisphosphoglycerate + phosphate => (2R)-2,3-bisphosphoglycerate + ATP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28865", "l": "H(+)(in) + lactose(out) => H(+)(out) + lactose(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0001069", "l": "regulatory region RNA binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008833", "l": "deoxyribonuclease IV (phage-T4-induced) activity"}, {"i": "MetaCyc:3.1.21.2-RXN"}, {"i": "EC:3.1.21.2", "l": "\"Deoxyribonuclease IV\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23236", "l": "[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol"}, {"i": "EC:3.1.1.61", "l": "\"Protein-glutamate methylesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018807", "l": "RAC3 GDIs block activation of RAC3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40540", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029471", "l": "Hydrolysis of PC to PA by PLD (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009378", "l": "Estrogen-responsive CCND1 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36974", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-4-dehydro-6-deoxy-alpha-D-allose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375140", "l": "CDO binds promyogenic cadherins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982768", "l": "GH:GHR:JAK2 complex undergoes a conformational change (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.2.8"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140233", "l": "intracellular cAMP-activated cation channel activity involved in regulation of postsynaptic membrane potential"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33639", "l": "ATP + CoA + tetracosanoate = AMP + diphosphate + tetracosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11141", "l": "alpha-D-mannose 1-phosphate => D-mannose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64722", "l": "H(+)(in) + pyruvate(in) => H(+)(out) + pyruvate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110322", "l": "Formation of Pol zeta complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10254", "l": "L-cysteine + phosphate => H(+) + hydrogen sulfide + O-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166817", "l": "Cleavage of C3 by C3 convertases (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190541", "l": "Association of Cx43  with TJP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928656", "l": "gamma-secretase cleaves EPHB2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63148", "l": "H2O + N-(9Z-octadecenoyl)-taurine = (9Z)-octadecenoate + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61340", "l": "(S)-methylmalonyl-CoA + H(+) = CO2 + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451418", "l": "Pellino ubiquitinates IRAK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23861", "l": "acetyl-CoA + deacetylcephalosporin C => cephalosporin C + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786190", "l": "CMBL hydrolyses OM to OLMS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58896", "l": "4-hydroxybutanoate + ATP + CoA = 4-hydroxybutanoyl-CoA + ADP + phosphate"}, {"i": "EC:6.2.1.56", "l": "\"4-hydroxybutyrate--CoA ligase (ADP-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31397", "l": "all-trans-4,4'-diapophytofluene + FADH2 => 15-cis-4,4'-diapophytoene + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42576", "l": "2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + H2O = 2-methylpropanoate + 2-oxopent-4-enoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56669", "l": "7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) => 7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66476", "l": "gypsogenate + UDP-alpha-D-glucose = gypsogenate 28-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21598", "l": "2-aminomalonate semialdehyde + H(+) + NADPH => L-serine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28015", "l": "S-adenosyl-L-methionine + thiocyanate => methyl thiocyanate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50645", "l": "2-(3-methylsulfanyl)propylmalate => 3-(3-methylsulfanyl)propylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189406", "l": "4 PBGs bind to form HMB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44276", "l": "eicosanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(2-oxohenicosyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27295", "l": "D-glucose 6-phosphate + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) => 6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63806", "l": "GDP-beta-L-galactose => GDP-beta-L-gulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804006", "l": "NO and NO2 react to N2O3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9617927", "l": "FOXO4 binds ATXN3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54859", "l": "H(+) + NADPH + O2 + octan-3-one <=> ethyl hexanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944254", "l": "Association of procollagen type XXVI (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9724685", "l": "IgE binds omalizumab (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679029", "l": "C-ter TLR7 dimer binds HCQ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017855", "l": "NICD3 binds to TACC3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0034327", "l": "hexanoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030729", "l": "acetoacetate-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47478", "l": "(2E)-tetradecenoyl-CoA => (3E)-tetradecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66183", "l": "ATP + bilirubin-glucuronoside(in) + H2O <=> ADP + bilirubin-glucuronoside(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696997", "l": "USP24 deubiquitinates DDB2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63398", "l": "AH2 + Fe(II)-hydroxyheme i => A + Fe(II)-heme i + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63559", "l": "dynorphin A-(1-13) + H2O <=> dynorphin A-(1-12) + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47252", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853801", "l": "PSPN binds RET:GFRA4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42810", "l": "3 reduced coenzyme F420-(gamma-Glu)(n) + sulfite => 2 H(+) + 3 H2O + hydrogen sulfide + 3 oxidized coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047197", "l": "triglyceride-sterol O-acyltransferase activity"}, {"i": "MetaCyc:2.3.1.77-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047015", "l": "3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102352", "l": "phosphatidate kinase activity"}, {"i": "MetaCyc:RXN-13336"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57766", "l": "3-methyl-4-nitrocatechol + NAD(+) + nitrite => 2,6-dinitrotoluene + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265428", "l": "Interaction of integrin alpha9beta1 with VCAM1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47885", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210282", "l": "Interaction of GPVI and FceRI gamma (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.26"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64741", "l": "H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine => 3-methyl-3-sulfanylhexan-1-ol + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46093", "l": "(25R)-cholest-5-ene-3beta,26-diol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta-hydroxy-5-cholesten-26-al + 2 H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37098", "l": "(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(12Z,15Z,18Z,21Z)-tetracosatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39464", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA => (2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110218", "l": "Cleavage of uracil by TDG glycosylase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31355", "l": "dimethyl sulfide + H(+) + NADH + O2 = formaldehyde + H2O + methanethiol + NAD(+)"}, {"i": "EC:1.14.13.131", "l": "\"Dissimilatory dimethyl-sulfide monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982775", "l": "Growth hormone receptor dimerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.32"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809707", "l": "MTMR12 binds MTMR2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51523", "l": "(S)-reticuline + S-adenosyl-L-methionine <=> (S)-tembetarine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55498", "l": "ent-cassa-12,15-dien-2beta,3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59257", "l": "Fe(III)-enterobactin + H2O => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391156", "l": "Phosphorylation of ITIM motif in SIRP alpha (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61601", "l": "[DsbD protein]-disulfide + [protein]-dithiol => [DsbB protein]-dithiol + [protein]-disulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39317", "l": "(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O => (3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983150", "l": "Proteasomal cleavage of substrate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33874", "l": "(S)-2-ureidoglycine + H2O <=> glyoxylate + NH4(+) + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56729", "l": "4-hydroxy-all-trans-beta-carotene + AH2 + O2 => 4,4-dihydroxy-all-trans-beta-carotene + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32767", "l": "cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Pro) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5679239", "l": "ULK complex translocates to the ER (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050264", "l": "rifamycin-B oxidase activity"}, {"i": "KEGG.REACTION:R03736"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9678925", "l": "NR3C1 binds NR3C1 agonists (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35525", "l": "N-ethylsuccinimide + NADP(+) => H(+) + N-ethylmaleimide + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63051", "l": "H2O + pravastatin lactone <=> H(+) + pravastatin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54397", "l": "1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54203", "l": "N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66734", "l": "ADP + H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(out) + phosphate => ATP + H2O + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24581", "l": "D-sorbitol 6-phosphate + H2O => D-sorbitol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26162", "l": "thalianol => (S)-2,3-epoxysqualene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195251", "l": "Assembly of the destruction complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19177", "l": "L-lysine = (3S)-3,6-diaminohexanoate"}, {"i": "EC:5.4.3.2", "l": "\"Lysine 2,3-aminomutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-164617", "l": "Elongation of Extended Telomeric Chromosome End (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140660", "l": "cytoskeletal motor activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33046", "l": "(1R,4R)-camphor + H(+) + NADPH + O2 <=> (+)-6-exo-hydroxycamphor + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37829", "l": "2,4-dichlorophenol + CO2 + pyruvate + succinate => (S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102739", "l": "(gibberellin-36), 2-oxoglutarate:oxygen oxidoreductase activity"}, {"i": "MetaCyc:RXN-7591"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47993", "l": "H(+)(in) + NAD(+) + NADPH => H(+)(out) + NADH + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61200", "l": "acetyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] = CoA + myricetin 3-O-[(6-O-acetyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004951", "l": "cholecystokinin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201608", "l": "Caspase-mediated cleavage of alpha adducin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65353", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2262777", "l": "TRAF6 binds to p-IRAK2   (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37437", "l": "a 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-573296", "l": "Activated TRAF6 recruits TAK1 kinase complex upon TLR7 or TLR21 stimulation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032137", "l": "guanine/thymine mispair binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50807", "l": "glutathione + prostaglandin J2 <=> prostaglandin J2-S-(R)-glutathione"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903794", "l": "cortisol binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52415", "l": "4-phospho-D-erythronate + NAD(+) <=> 3-dehydro-4-O-phospho-D-erythronate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27701", "l": "GDP-beta-L-galactose + phosphate <=> beta-L-galactose 1-phosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57527", "l": "a 5'-triphospho-guanosine-ribonucleotide-tRNA(His) + H2O <=> a 5'-phospho-guanosine-ribonucleotide-tRNA(His) + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49135", "l": "an adenosine in tRNA + S-adenosyl-L-methionine <=> an N(1)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15621", "l": "an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP"}, {"i": "EC:2.4.1.122", "l": "\"N-acetylgalactosaminide beta-1,3-galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45346", "l": "globoside NORint (d18:1(4E)) + H(+) + UDP => globoside NOR1 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33203", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950782", "l": "p-STAT1 binds p-STAT3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46946", "l": "H(+) + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] + NADPH => (S)-2-amino-6-oxohexanoate + holo-[LYS2 peptidyl-carrier protein] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34685", "l": "alpha-D-ribose 1-methylphosphonate 5-phosphate + diphosphate + H(+) => alpha-D-ribose 1-methylphosphonate 5-triphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63638", "l": "a medium-chain fatty acyl-[ACP] + AMP + H(+) => a medium-chain fatty acyl-AMP + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47266", "l": "AMP + diphosphate + pristanoyl-CoA => 2,6,10,14-tetramethylpentadecanoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102602", "l": "cytochrome P450 dependent 16beta-hydroxy-beta-amyrin epoxidase activity"}, {"i": "MetaCyc:RXN-15386"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28621", "l": "2-methylbutyronitrile + H(+) + NADPH + O2 <=> 2-hydroxy-2-methylbutanenitrile + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683546", "l": "FURIN binds furin inhibitors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45578", "l": "(2S)-methylsuccinyl-CoA => (2R)-ethylmalonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030410", "l": "nicotianamine synthase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034256", "l": "chlorophyll(ide) b reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55447", "l": "O2 + oleanolate + reduced [NADPH--hemoprotein reductase] <=> cochalate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102406", "l": "omega-hydroxypalmitate O-sinapoyl transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57661", "l": "(+)-valencene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (+)-nootkatone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018766", "l": "RHOU binds effectors at the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46491", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51552", "l": "D-sorbitol + NADP(+) = H(+) + L-xylo-3-hexulose + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008532", "l": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15239", "l": "2 [Fe(II)-cytochrome c2] + H(+) + NADP(+) => 2 [Fe(III)-cytochrome c2] + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43719", "l": "[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate <=> [glutamine synthetase]-L-tyrosine + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465940", "l": "atRAL is reduced to atROL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31021", "l": "4 A + all-trans-4,4'-diapolycopene-4,4'-dial + 6 H2O => 4 AH2 + all-trans-4,4'-diapolycopene + 4 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604732", "l": "Autocatalytic activation of proMMP13 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434989", "l": "SEMA7A binds to PLXNC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46192", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] = 3beta,7alpha-dihydroxyandrost-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018685", "l": "alkane 1-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44745", "l": "4 H(+) + 4 malonyl-CoA => (3,5-dihydroxyphenyl)acetyl-CoA + 4 CO2 + 3 CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22011", "l": "L-homoserine + succinyl-CoA <=> CoA + O-succinyl-L-homoserine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158860", "l": "SULT1A1 dimer sulfonates NHABP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.39", "l": "\"Adenain\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850997", "l": "TRIM27 binds PTEN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000995", "l": "RNA polymerase III general transcription initiation factor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9619355", "l": "CaMKK autophosphorylates in the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46865", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli) => a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61990", "l": "5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(72) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15994", "l": "anthraniloyl-CoA + 2 H(+) + 2 NADPH + O2 => 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27945", "l": "(3R)-3-hydroxy-D-aspartate <=> NH4(+) + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66012", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + hypobromite + L-methionyl-[collagen] = [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-351208", "l": "Spermidine  => N-acetylated spermidine (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19696", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+) <=> 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38365", "l": "glycerol + H(+) + octadecanoate => 1-octadecanoylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010355", "l": "homogentisate farnesyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49321", "l": "all-trans-violaxanthin => (5R,6S)-5,6-epoxi-capsanthin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016085", "l": "myoinhibitory hormone activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651697", "l": "Defective SLC34A2 does not cotransport Pi, 3Na+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47979", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46919", "l": "H2O + juvenile hormone I <=> H(+) + juvenile hormone I carboxylate + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39642", "l": "(3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA <=> (2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109701", "l": "PDPK1 binds PIP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55670", "l": "11-cis-retinal--[retinol-binding protein] + H(+) + NADH => 11-cis-retinol--[retinol-binding protein] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41068", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34393", "l": "[beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 H(+) + 28 UDP => beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 UDP-alpha-D-galactofuranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42320", "l": "a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000979", "l": "RNA polymerase II core promoter sequence-specific DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22085", "l": "(S)-2,3-diaminopropanoate + H(+) + H2O => 2 NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3149539", "l": "MTR transfers CH3 group from MTHF to cob(I)alamin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1183058", "l": "Expression of Adiponectin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41940", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate = [amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ADP + H(+) + phosphate"}, {"i": "EC:6.3.2.43", "l": "\"[Amino-group carrier protein]--L-2-aminoadipate ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62833", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc]oxy}nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417820", "l": "P2Y9 receptor can bind to LPA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32509", "l": "6-hydroxy-3-isopropenylheptanoate + H(+) => 4-isopropenyl-7-methyloxepan-2-one + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56492", "l": "hederagenin + O2 + reduced [NADPH--hemoprotein reductase] = gypsogenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55434", "l": "carnosate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 11-hydroxyferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682709", "l": "LGI4 binds ADAM22,23,11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964475", "l": "DREAM complex binds the TOP2A gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156910", "l": "Formation of eEF1B complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57843", "l": "1D-myo-inositol 1,3-bisphosphate + H2O <=> 1D-myo-inositol 1-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114264", "l": "Translocation of activated BAX to the mitochondria (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52230", "l": "3 A + biliverdin beta + CO + Fe(2+) + 3 H2O => 3 AH2 + 2 H(+) + heme b + 3 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26017", "l": "3,7-dideoxy-D-threo-hepto-2,6-diuolosonate <=> 3-dehydroquinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45231", "l": "a (3E)-enoyl-CoA <=> a 4-saturated (2E)-enoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47513", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => isocholate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694428", "l": "LMAN family proteins bind glycosylated cargo (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174119", "l": "Free APC/C phosphorylated by Plk1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901074", "l": "MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451366", "l": "Activation of p38MAPK by DSCAM (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55702", "l": "an N-acyl-(4R)-4-hydroxysphinganine + H(+) + mannosyldiinositol-1-phosphate => an inositol phosphomannosylinositol-1-phospho-N-acyl-(4R)-4-hydroxysphinganine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190256", "l": "FGFR1c binds to FGF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218804", "l": "p38 MAPK activation by VEGFR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14448", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32232", "l": "(6S)-NADPHX + ATP => ADP + H(+) + NADPH + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.74", "l": "\"Glucan 1,4-beta-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983152", "l": "Transfer of ubiquitin from E1 to E2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706323", "l": "Active FLT3 binds to SLA2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38431", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O = (9Z)-octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31410", "l": "all-trans-4,4'-diaponeurosporene + FAD + H(+) <=> all-trans-4,4'-diapolycopene + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668467", "l": "2xTNFR2 binds TNFA trimer:TNFR2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028583", "l": "Phosphorylation of YAP by LATS2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26126", "l": "(S)-1-pyrroline-5-carboxylate + FADH2 => FAD + L-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52674", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate => 2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54956", "l": "ATP + CoA + OPC-6 = AMP + diphosphate + OPC-6-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.115", "l": "\"Anthocyanidin 3-O-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5631885", "l": "PRDX1 overoxidizes (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032395", "l": "MHC class II receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166542", "l": "beta-NGF dimer binds to TrkA receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-688136", "l": "TNFAIP3 (A20) deubiquitinates RIP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31637", "l": "5-dehydro-4-deoxy-D-glucuronate + beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc => beta-D-Delta(4)-GlcA-(1->4)-beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41707", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103057", "l": "gibberellin A19, 2-oxoglutarate:oxygen oxidoreductase activity"}, {"i": "MetaCyc:RXN1F-169"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-380930", "l": "Phosphorylated AMPK binds AMP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48776", "l": "O2 + prostaglandin H2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxyprostaglandin H2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24365", "l": "H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD(+) => 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29465", "l": "K(+)(out) => K(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.117", "l": "\"Hydroxycinnamoyl-CoA reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912790", "l": "CBL binds CRK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419166", "l": "GEFs activate RhoA,B,C (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202127", "l": "eNOS synthesizes NO (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14864", "l": "(S)-dihydroorotate + NADP(+) <=> H(+) + NADPH + orotate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29529", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51134", "l": "2-deoxy-D-ribose 5-phosphate + a purine nucleobase => a purine 2'-deoxyribonucleoside 5'-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62912", "l": "H(+) + NADH + O2 + toralactone = 1-(3,4,5-trihydroxy-7-methoxynaphthalen-2-yl)propan-2-one + CO2 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451366", "l": "Activation of p38MAPK by DSCAM (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54371", "l": "acetaldehyde + H(+) + pyruvate <=> acetoin + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57052", "l": "3-oxoisoapionate + H(+) = CO2 + L-erythrulose"}, {"i": "EC:4.1.1.120", "l": "\"3-oxoisoapionate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018758", "l": "RHOH binds effectors at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13970", "l": "(RNA)-3'-(3'-phosphooxy-ribonucleotide) + GTP => (RNA)-3'-(2',3'-cyclophosphooxy)-ribonucleotide + diphosphate + GMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41634", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phospho-L-serine + ethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852019", "l": "MET bound PI3K generates PIP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193653", "l": "NGF homodimer binds to p75NTR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43364", "l": "L-erythro-N-acylsphing-4-enine + UDP-alpha-D-glucose = beta-D-glucosyl-L-erythro-N-acylsphing-4-enine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46407", "l": "2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 <=> (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734713", "l": "ORC6 translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950504", "l": "IL27 binds CRLF1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202714", "l": "CD58 binds CD2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187575", "l": "Ubiquitination of phospho-p27/p21 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45630", "l": "holo-[CmaA peptidyl-carrier protein] + L-alloisoleucyl-[CmaD peptidyl-carrier protein] => holo-[CmaD peptidyl-carrier protein] + L-alloisoleucyl-[CmaA peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50982", "l": "prostaglandin E1(in) => prostaglandin E1(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204465", "l": "Basigin interacts with CD43 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34098", "l": "carboxyspermidine + H(+) <=> CO2 + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54120", "l": "coelenterazine h + O2 = coelenterazine h dioxetanone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47798", "l": "an aromatic aldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin] => an aralkylamine + H2O + 2 oxidized [azurin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64693", "l": "isobutanol + NAD(+) => 2-methylpropanal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709842", "l": "MAVS binds TOMM70 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29666", "l": "H(+)(in) + xanthine(in) <=> H(+)(out) + xanthine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-377640", "l": "Autophosphorylation of SRC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651792", "l": "LIG1 and POLB dissociate from repaired dsDNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17296", "l": "2 H(+) + NADH + O2 + precorrin-3A <=> H2O + NAD(+) + precorrin-3B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51897", "l": "H2O + N(1)-acetylspermine => acetate + spermine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38817", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21040", "l": "CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.2.7.4", "l": "\"Anaerobic carbon-monoxide dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22411", "l": "dimethylallyl diphosphate + isopentenyl diphosphate <=> (2E)-geranyl diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120274", "l": "virus coreceptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33658", "l": "(9Z)-octadecenoate(out) <=> (9Z)-octadecenoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72139", "l": "Formation of the active Spliceosomal C (B*) complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46072", "l": "(2E)-hexadecenoyl-CoA + H(+) + NADH = hexadecanoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58569", "l": "15alpha-stemmadenine + acetyl-CoA => CoA + O-acetyl-15alpha-stemmadenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.4", "l": "\"Tripeptide aminopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65084", "l": "asperaculane E + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = aculene D + CO2 + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18351", "l": "AMP + diphosphate + L-aspartyl-tRNA(Asx) => ATP + L-aspartate + tRNA(Asx)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451403", "l": "Interaction of nephrin with adherens junction-associated proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61875", "l": "1-O-methyl-(9Z,12Z)-octadecadienoate + O2 <=> 1-O-methyl-(9R)-hydroperoxy-(10E,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11114", "l": "(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate => H2O + isochorismate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877620", "l": "ECE2 cleaves EDN1(53-90) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35175", "l": "novobiocin(in) = novobiocin(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042043", "l": "neurexin family protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39292", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57801", "l": "2,3-dinitrotoluene + NADH + O2 => 4-methyl-3-nitrocatechol + H(+) + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798748", "l": "Exocytosis of secretory granule lumen proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112436", "l": "Formation of Elongin complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034024", "l": "glutamate-putrescine ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58449", "l": "N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13931", "l": "putrescine + urea => agmatine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61936", "l": "ATP + cycloheximide(in) + H2O = ADP + cycloheximide(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29120", "l": "a ubiquinol + nitrate => a ubiquinone + H2O + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13090", "l": "6 [Fe(III)cytochrome c] + 2 H2O + NH4(+) => 6 [Fe(II)cytochrome c] + 8 H(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102351", "l": "gamma-aminobutyrate transaminase (glyoxylate dependent) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44637", "l": "2,4-dinitroanisole + H2O => 2,4-dinitrophenol + H(+) + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23721", "l": "ATP + hydrogencarbonate + propanoyl-CoA => (S)-methylmalonyl-CoA + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.89"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66156", "l": "butanoyl-CoA + tyramine = CoA + H(+) + N-butanoyltyramine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0016433", "l": "rRNA (adenine) methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37989", "l": "2-methyl-6-phytyl-1,4-benzene-1,4-diol => delta-tocopherol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8873946", "l": "OTUD3 deubiquitinates PTEN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66842", "l": "asperterpenoid B + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => asperterpenoid A + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40779", "l": "2-aminopentanenitrile + H(+) + 2 H2O = L-2-aminopentanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35222", "l": "8-oxo-dADP + H2O <=> 8-oxo-dAMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647980", "l": "mature RAS proteins translocate to plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9617927", "l": "FOXO4 binds ATXN3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.264", "l": "\"L-idonate 5-dehydrogenase (NAD(P)(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16788", "l": "an adenosine in tRNA + S-adenosyl-L-methionine <=> an N(6)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209536", "l": "IkB is ubiquitinated and degraded (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34173", "l": "(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O => L-aspartate 4-semialdehyde + pyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018785", "l": "haloacetate dehalogenase activity"}, {"i": "RHEA:11044", "l": "a haloacetate + H2O = a halide anion + glycolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3266557", "l": "Factor I cleaves iC3b (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9617595", "l": "SGTA binds mislocalized membrane protein (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "77.690207805941611", "identifiers": [{"i": "GO:1904680", "l": "peptide transmembrane transporter activity"}, {"i": "REACT:R-HSA-1500817", "l": "Glutathione is taken up by the bacterium (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0101011", "l": "inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate 1-diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53663", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655343", "l": "Activated FGFR2 mutants bind PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030944", "l": "DDEL sequence binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418456", "l": "cGMP is degraded by PDEs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390649", "l": "CHRM1,3,5 bind acetylcholine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043872", "l": "lysine:cadaverine antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932400", "l": "MYC:MAX binds the CDC25A gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592436", "l": "Initial activation of proMMP9 by MMPs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62434", "l": "a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-thioadenosine => a uridine in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592398", "l": "Activation of proMMP8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31579", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate"}, {"i": "EC:5.4.4.5", "l": "\"9,12-octadecadienoate 8-hydroperoxide 8R-isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55357", "l": "11-cis-retinol => 13-cis-retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18230", "l": "glycolate + NAD(+) => glyoxylate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940134", "l": "FOLR2 binds FOLA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9641111", "l": "Parkin transfers Ub to misfolded proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26542", "l": "(R)-piperazine-2-carboxamide + H2O = (R)-piperazine-2-carboxylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198563", "l": "IDO1 dioxygenates L-Trp to NFK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42697", "l": "H2O + hercynylselenocysteine => NH4(+) + pyruvate + selnoneine thione"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008980", "l": "propionate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20420", "l": "coelenterazine + O2 <=> CO2 + coelenteramide + hnu"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53659", "l": "(5S,6R)-dihydroxy-(7E,9E,11Z,14Z)-eicosatetraenoate + O2 <=> (5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58622", "l": "decanamide + glyoxylate => N-decanoyl-(2S)-hydroxyglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25106", "l": "ADP + H(+) + pyridoxamine 5'-phosphate => ATP + pyridoxamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65040", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + a tri-(9Z,12Z-octadecadienoyl)-monolysocardiolipin = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374899", "l": "Release of noradrenaline  at the synapse (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050539", "l": "maleimide hydrolase activity"}, {"i": "RHEA:24476", "l": "H2O + maleimide = H(+) + maleamate"}, {"i": "EC:3.5.2.16", "l": "\"Maleimide hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450325", "l": "c-FOS activation by phospho ERK1/2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103087", "l": "methylthiopentylmalate dehydrogenase activity"}, {"i": "MetaCyc:RXNQT-4171"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102562", "l": "hydroxyproline O-arbinofuranose transferase activity"}, {"i": "RHEA:49472", "l": "trans-4-hydroxy-L-prolyl-[protein] + UDP-beta-L-arabinofuranose = H(+) + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl-[protein] + UDP"}, {"i": "MetaCyc:RXN-15011"}, {"i": "EC:2.4.2.58", "l": "\"Hydroxyproline O-arabinosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27638", "l": "phosphate + xanthosine = alpha-D-ribose 1-phosphate + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222346", "l": "AhpC reduces H2O2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25291", "l": "ethanol + NAD(+) => acetaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2106615", "l": "Removal of siRNA passenger strand (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004784", "l": "superoxide dismutase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674022", "l": "BRAP autoubiquitinates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983421", "l": "Journey of cargo through Golgi complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45905", "l": "devancoaminyl-vancomycin + dTDP-beta-L-vancosamine => dTDP + epivancomycin + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043765", "l": "T/G mismatch-specific endonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75079", "l": "Formation of AT-AC C complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430347", "l": "MigFilin associates with Filamin and F-actin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800816", "l": "TP53 or TP63 stimulates PERP gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003917", "l": "DNA topoisomerase type I (single strand cut, ATP-independent) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27471", "l": "acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine => H2O + N,N'-diacetylchitobiose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36947", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32192", "l": "H2O + L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-oxoglutarate + 2 H(+) + NH4(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32983", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + 2 H2O = 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-1D-myo-inositol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106277", "l": "biliverdin reductase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22857", "l": "(7S)-salutaridinol + acetyl-CoA => (7S)-O-acetylsalutaridinol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51267", "l": "4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] <=> (10bS,4aR)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49164", "l": "a bacteriochlorophyllide c + H2O + S-adenosyl-L-methionine = 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide c + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036384", "l": "cytidine-diphosphatase activity"}, {"i": "RHEA:64880", "l": "CDP + H2O = CMP + H(+) + phosphate"}, {"i": "EC:3.6.1.6", "l": "\"Nucleoside diphosphate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48510", "l": "3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH => cholate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49246", "l": "18-oxo-resolvin E1 + H(+) + NADH => NAD(+) + resolvin E1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53909", "l": "(2E)-butenoyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-(2E)-butenoyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25044", "l": "H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate <=> L-selenocysteinyl-tRNA(Sec) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37441", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.200", "l": "\"Exo-chitinase (non-reducing end)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0000497", "l": "DNA template activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350475", "l": "FLW:MBS complex dephosphorylates SQH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64336", "l": "H(+) + 2 malonyl-CoA + nicotinyl-CoA = 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27610", "l": "formate + H(+) = CO2 + H2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428917", "l": "G13 activation by TP receptor (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52150", "l": "an aliphatic desulfo-glucosinolate + UDP => an (E)-omega-(methylsulfanyl)alkyl-thiohydroximate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166817", "l": "Cleavage of C3 by C3 convertases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382054", "l": "PDGF binds to extracellular matrix proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28564", "l": "pyridoxamine 5'-phosphate + pyruvate => D-alanine + pyridoxal 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191784", "l": "snRNA Cap hypermethylation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48553", "l": "1-(9S,13S-12-oxo-10,15Z-phytodienoyl)-2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O => (10Z,15Z)-12-oxophytodienoate + 2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61619", "l": "H(+) + L-proline betaine + NADH + O2 <=> formaldehyde + H2O + N-methyl-L-proline + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794346", "l": "NRXNs bind NLGNs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3780997", "l": "PPP1R3C binds to glycogen:GYG2:GYS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52307", "l": "H2O + L-ectoine <=> (2S)-2-acetamido-4-aminobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37470", "l": "1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+) <=> 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36732", "l": "1-nitrocyclohexan + NADP(+) => 1-nitrocyclohexene + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24462", "l": "acetyl-[ACP] + CO2 => H(+) + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62653", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA => 6 CO2 + 7 CoA + H2O + YWA1"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102448", "l": "rhamnetin 4'-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-13934"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371567", "l": "DBC1 is phosphorylated by ATM/ART (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47274", "l": "bisanhydrobacterioruberin + H2O => monoanhydrobacterioruberin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16866", "l": "choloyl-CoA + propanoyl-CoA => 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54762", "l": "5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate => ATP + H(+) + pyridinium-3,5-dicarboxylate mononucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29942", "l": "H(+)(in) + phosphate(in) <=> H(+)(out) + phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913675", "l": "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237129", "l": "Acireductone is created (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641134", "l": "SMURF2 binds AXIN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855232", "l": "RELN:VLDLR binds DAB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868071", "l": "Clathrin recruits PIK3C2A (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40913", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203156", "l": "Platelet-derived TREM-1 ligand binds to TREM-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981539", "l": "C3b binds to cell surface (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23865", "l": "4-CDP-2-C-methyl-D-erythritol 2-phosphate => 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41999", "l": "globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose <=> globoside GalGb4Cer (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60200", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate"}, {"i": "EC:1.14.11.66", "l": "\"[Histone H3]-trimethyl-L-lysine(9) demethylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111883", "l": "Hydrolysis of phosphatidylcholine (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592314", "l": "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64095", "l": "3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 <=> 3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018715", "l": "9-phenanthrol UDP-glucuronosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683964", "l": "ATM phosphorylates EYA1-4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429663", "l": "SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27935", "l": "(3S)-3-hydroxy-D-aspartate => glycine + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "ic": "76.412572999466406", "identifiers": [{"i": "GO:0010333", "l": "terpene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64257", "l": "dodecanoyl-CoA + glycine => CoA + H(+) + N-dodecanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156699", "l": "Inactivation of Wee1 kinase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30480", "l": "L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36688", "l": "hexadecanoyl-CoA + sphing-4-enine => CoA + H(+) + N-hexadecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41470", "l": "H(+) + H2O + oryzalexin E + oxidized [NADPH--hemoprotein reductase] => ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951676", "l": "RUNX3 binds TEADs and YAP1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43442", "l": "H2O + N-hexadecanoylsphinganine => hexadecanoate + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32617", "l": "(6E)-8-oxogeranial + H(+) + NADPH => (6E)-8-oxogeraniol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62765", "l": "4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 => 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199161", "l": "Fc gamma receptors interact with antigen-bound IgG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.121"}]}
{"type": "biolink:MolecularActivity", "ic": "81.790986234327661", "identifiers": [{"i": "GO:0000978", "l": "RNA polymerase II cis-regulatory region sequence-specific DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66187", "l": "3',5'-cyclic AMP(in) + ATP + H2O <=> 3',5'-cyclic AMP(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333612", "l": "MeSebGalNac is oxidatively cleaved to MeSeO2H and 2-acetamidoglucal (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37823", "l": "(R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 = 2,4-dichlorophenol + CO2 + pyruvate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647977", "l": "ICMT methylates S-Farn RAS proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29500", "l": "(2E,6E)-farnesyl diphosphate => (+)-alpha-barbatene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68637", "l": "CDC6 protein is synthesized under the control of E2F transcription factors (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391211", "l": "Trace amine-associated receptors can bind trace amines (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0050521", "l": "alpha-glucan, water dikinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43019", "l": "an S-alkyl-L-cysteine <=> 2-aminoprop-2-enoate + an alkyl thiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203979", "l": "Coat Assembly (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22151", "l": "a plastoquinol + 2 H(+)(in) + 2 oxidized [plastocyanin] <=> a plastoquinone + 4 H(+)(out) + 2 reduced [plastocyanin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57110", "l": "1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848758", "l": "PTK6 phosphorylates AKT1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23681", "l": "a ribonucleoside 5'-triphosphate + H2O => a ribonucleoside 5'-diphosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008948", "l": "oxaloacetate decarboxylase activity"}, {"i": "REACT:R-HSA-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9611277", "l": "P2RY12 binds P2RY12 antagonists (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483107", "l": "GPETA is hydrolyzed to ETA and G3P by GPCPD1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65701", "l": "chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] => cholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674558", "l": "p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56385", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 => (5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.84", "l": "\"Glucan 1,3-alpha-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54853", "l": "H(+) + heptan-4-one + NADPH + O2 => H2O + NADP(+) + propyl butanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050106", "l": "monomethyl-sulfatase activity"}, {"i": "KEGG.REACTION:R01145"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60700", "l": "a 1-acyl-sn-glycero-3-phosphocholine = a 1-acyl-sn-glycero-2,3-cyclic phosphate + choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27774", "l": "2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388831", "l": "Phosphorylation of CD28 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977619", "l": "CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654404", "l": "Activated FGFR2 binds SHC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12911", "l": "2 [Fe(III)cytochrome] + H2O + nitrite => 2 [Fe(II)cytochrome] + 2 H(+) + nitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59731", "l": "(2R)-ethylmalonyl-CoA <=> (2S)-ethylmalonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.17", "l": "\"Quinoline 2-oxidoreductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11797", "l": "ecdysone + O2 => 3-dehydroecdysone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59767", "l": "L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + octadecanoyl-CoA <=> CoA + H(+) + N(6)-octadecanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10551", "l": "L-arginine + O2 <=> 4-guanidinobutanamide + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66111", "l": "2-oxobutanoate + L-cysteine <=> (2S)-2-aminobutanoate + 2-oxo-3-sulfanylpropanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32069", "l": "NH4(+) + urate => 8-oxoguanine + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77608", "l": "Binding of A1CF to stem-looped RNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990605", "l": "GU repeat RNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29613", "l": "H(+) + NADPH + 2 nitric oxide => H2O + NADP(+) + nitrous oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48053", "l": "n 3'-phosphoadenylyl sulfate + dermatan => n adenosine 3',5'-bisphosphate + dermatan 4'-sulfate + n H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.1.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10327", "l": "an L-glycol + NADP(+) <=> a 2-hydroxycarbonyl + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.34", "l": "\"Acyl-lipid (9+3)-(E)-desaturase\""}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0038181", "l": "bile acid receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40713", "l": "1-O-hexadecylglycerone 3-phosphate + H(+) + octadecanoate => 1-octadecanoylglycerone 3-phosphate + hexadecan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61168", "l": "quercetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = H(+) + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877396", "l": "IL2RA (CD25) gene expression is stimulated by FOXP3 and inhibited by RUNX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879907", "l": "Tyrosine kinases phosphorylate the receptor (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54553", "l": "1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13158", "l": "(R)-glycerate + CO2 + NADP(+) => 2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43497", "l": "L-gulonate + NAD(+) => H(+) + keto-D-fructuronate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52252", "l": "a bacteriochlorophyllide c + H2O + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + a bacteriochlorophyllide e + 2 H(+) + 2 L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55111", "l": "3-oxononanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxynonanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39062", "l": "26-hydroxyhexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 26-oxohexacosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46813", "l": "4,4-dimethyl-8,14-cholestadien-3beta-ol + H(+) + NADPH => 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29303", "l": "2 H(+)(in) + succinate(in) = 2 H(+)(out) + succinate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322427", "l": "Beta-catenin recruits CBP/p300 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57714", "l": "4-O-(beta-D-glucosyl)-4-trans-sinapoyl aldehyde + H(+) + UDP => (E)-sinapoaldehyde + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851890", "l": "MET phosphorylates SHC1-2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862300", "l": "LYZ binds bacterial peptidoglycan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58963", "l": "benzaldehyde + H2O + O2 <=> benzoate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140407", "l": "L-alanine:proton antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15863", "l": "3-ADP-glycerate + phosphate => 3-ADP-2-phosphoglycerate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015506", "l": "nucleoside:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11070", "l": "(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose => (5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625091", "l": "FOXO1,FOXO3 bind ABCA6 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54475", "l": "1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83660", "l": "Membrane-anchored TNF-alpha binds TNFR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25967", "l": "(R)-benzoin + NADP(+) <=> benzil + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34920", "l": "thiamine(in) => thiamine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668735", "l": "RAC1:GTP binds NOX3 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42512", "l": "5-acetamidopentanoate + H2O = 5-aminopentanoate + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867047", "l": "PTPN3 dephosphorylates EPS15 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49012", "l": "aurachin C + H(+) + NADH + O2 = aurachin C epoxide + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61767", "l": "stevioside + UDP-alpha-D-glucose <=> H(+) + rebaudioside E + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097256", "l": "phenyllactate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65380", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidyl-adenosine in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204798", "l": "Interaction of Tie2 and p85 of PI3K (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4608855", "l": "PRICKLE1 is degraded by the proteasome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733969", "l": "Bile salts dissociate from FABP6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65463", "l": "acetyl-CoA + hexan-1-ol <=> CoA + hexyl acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39912", "l": "(2S,3S)-3-methylphenylalanine + 2-oxoglutarate => (3S)-2-oxo-3-phenylbutanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61135", "l": "(2R,3R)-dihydrokaempferol + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + kaempferol + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49595", "l": "2-hydroxyisobutanoyl-CoA <=> (3S)-3-hydroxybutanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66346", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + ADP + H(+) + phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379387", "l": "COMT transfers Met to DA to form 3MT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16911", "l": "2 [Fe(II)cytochrome c] + glyoxylate + 2 H(+) + NH4(+) => 2 [Fe(III)cytochrome c] + glycine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28285", "l": "(S)-beta-bisabolene <=> (S)-beta-macrocarpene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48981", "l": "3,4-dichlorocatechol + O2 => (2Z,4Z)-2,3-dichloromuconate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928604", "l": "SFKs phosphorylate VAV2,3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24674", "l": "ATP + cytidine = ADP + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466831", "l": "A2PE hydrolyses to A2E (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42489", "l": "(3R)-3-amino-3-phenylpropanoyl-CoA + baccatin III => 3'-N-debenzoyl-2'-deoxytaxol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61907", "l": "betaenone A + H(+) + NADPH + O2 <=> H2O + NADP(+) + stemphyloxin II"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22101", "l": "3,5-dibromo-4-hydroxybenzonitrile + 2 H2O => 3,5-dibromo-4-hydroxybenzoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014454", "l": "RHOG translocates to the ER membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42434", "l": "maleylacetate => 3-hydroxy-cis,cis-muconate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.37"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173739", "l": "Spontaneous hydrolysis of C3 thioester (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047886", "l": "farnesol dehydrogenase activity"}, {"i": "RHEA:14697", "l": "(2E,6E)-farnesol + NADP(+) = (2E,6E)-farnesal + H(+) + NADPH"}, {"i": "EC:1.1.1.216", "l": "\"Farnesol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33941", "l": "H2O + N(omega)-hydroxy-L-arginine + NAD(+) => H(+) + L-arginine + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27273", "l": "CoA + hexadecanal + NADP(+) <=> H(+) + hexadecanoyl-CoA + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103073", "l": "anandamide amidohydrolase activity"}, {"i": "RHEA:26136", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21693", "l": "CDP-glycerol + H2O => CMP + 2 H(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27726", "l": "5-dehydro-4-deoxy-D-glucarate = 2-hydroxy-3-oxopropanoate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0001163", "l": "RNA polymerase I transcription regulatory region sequence-specific DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950718", "l": "Expression of TCP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57443", "l": "2-methylanisole + O2 + reduced [NADH--hemoprotein reductase] <=> 2-hydroxytoluene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112385", "l": "Addition of nucleotides leads to transcript elongation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2530445", "l": "CD59 inhibits MAC formation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53576", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654515", "l": "KAL1 binds HS (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44927", "l": "2-oxoadipate + acetyl-CoA + H2O <=> (R)-dihomocitrate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782943", "l": "UV-DDB ubiquitinates XPC (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102296", "l": "4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65191", "l": "2-oxoglutarate + berkeleyone B + O2 <=> berkeleydione + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0061459", "l": "L-arginine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51199", "l": "chloride(out) + Na(+)(out) + serotonin(out) <=> chloride(in) + Na(+)(in) + serotonin(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388981", "l": "The Kiss receptor GPR54 binds kisspeptin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71239", "l": "2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227885", "l": "TBK1/IKK epsilon bind to TANK:TRAF3/TRAF6 complex followed by their activation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2214324", "l": "Collagen type VII dimerization (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38989", "l": "(2E)-nonenoyl-CoA + H2O2 => nonanoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2214351", "l": "PLK1 phosphorylates GORASP1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53449", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53994", "l": "(14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2176445", "l": "SMURF2 binds SMAD2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-450550", "l": "PKCalpha phosphorylates HuR (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61459", "l": "7-chlorotetracycline + H(+) + NADPH + O2 <=> (1S,10S,10aS)-3-(CONH2)-9-Cl-1-(Me2N)-3,3a,4,10-(HO)4-10-Me-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracen-6-olate + CO + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006503", "l": "MECP2 binds the PVALB gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53640", "l": "(2E,6E)-farnesyl diphosphate = (-)-alpha-amorphene + diphosphate"}, {"i": "EC:4.2.3.162", "l": "\"(-)-alpha-amorphene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099520", "l": "ion antiporter activity involved in regulation of presynaptic membrane potential"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.99.-", "l": "\"With other acceptors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140010", "l": "D-aspartate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34453", "l": "dTDP-beta-L-rhamnose => dTDP-6-deoxy-beta-L-talose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034784", "l": "pivalyl-CoA mutase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53100", "l": "2-hydroxyestrone + S-adenosyl-L-methionine = 2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58387", "l": "NADP(+) + octan-1-ol <=> H(+) + NADPH + octanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380780", "l": "Activation of Src (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430190", "l": "p-SLP-76 binds NCK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3215406", "l": "PRMT5 binds WDR77 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952419", "l": "SMURFs ubiquitinate RUNX3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44579", "l": "4-hydroxy-3-all-trans-nonaprenylbenzoate + H(+) <=> 2-all-trans-nonaprenylphenol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47149", "l": "a ubiquinone + caffeine + H2O => 1,3,7-trimethylurate + a ubiquinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691150", "l": "TFR2 dimer binds 2xholoTF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675206", "l": "PEA15 binds MAPK monomers and dimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428917", "l": "G13 activation by TP receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204871", "l": "Interaction of Tie2 and Grb2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072572", "l": "poly-ADP-D-ribose binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203774", "l": "Interaction of Csk with PAG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3234084", "l": "SUMOylation of TFAP2B with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18071", "l": "D-arginine => L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64952", "l": "dCDP + H2O = dCMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990915", "l": "structural constituent of ascospore wall"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32189", "l": "cholest-4-en-3-one => cholest-5-en-3-one"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034815", "l": "cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451310", "l": "Activation of Edited Kainate receptors (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60682", "l": "(+)-artemisinate + 2 H(+) + NADPH => (+)-artemisinic aldehyde + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36521", "l": "3-oxooctacosanyol-CoA + CO2 + CoA => H(+) + hexacosanoyl-CoA + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680812", "l": "nsp7 binds nsp8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63072", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA = 4 CO2 + 4 CoA + orcinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12499", "l": "2 Fe(2+) + 4 H2O + O2 <=> 6 H(+) + H2O2 + 2 iron(III) oxide-hydroxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-976801", "l": "Complement factor I complex formation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47588", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1c (d18:1(4E)) = CMP + ganglioside GQ1c (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404144", "l": "Parenchymal atROL translocates to HSCs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.128"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17656", "l": "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate <=> (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40764", "l": "(20S)-ginsenoside Re + H2O => (20S)-ginsenoside Rg1 + L-rhamnopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848776", "l": "PTK6 phosphorylates DOK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38585", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate => a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41994", "l": "5alpha-androstan-3,17-dione + H(+) + NADH => 17beta-hydroxy-5alpha-androstan-3-one + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000348", "l": "RANBP2 SUMOylates SP100 with SUMO2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912790", "l": "CBL binds CRK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784861", "l": "HSPG binds LPL dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16204", "l": "4-amino-4-deoxychorismate <=> 4-aminobenzoate + H(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22639", "l": "dCTP + H2O <=> dCMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161282", "l": "Elastic fibres bind associated proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222128", "l": "NOC2L binds TP53 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156682", "l": "PLK1 phosphorylates NUDC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-984689", "l": "Kinesin-7 is a dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204871", "l": "Interaction of Tie2 and Grb2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030943", "l": "mitochondrion targeting sequence binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75891", "l": "Abortive Initiation After Second Transition (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48637", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18889", "l": "D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + H(+) + UDP"}, {"i": "EC:2.4.1.15", "l": "\"Alpha,alpha-trehalose-phosphate synthase (UDP-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050481", "l": "mandelate 4-monooxygenase activity"}, {"i": "MetaCyc:MANDELATE-4-MONOOXYGENASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404135", "l": "RBP4 binds atROL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814555", "l": "Integrator complex processes the 3' end of snRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54745", "l": "9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23103", "l": "ATP + dAMP <=> ADP + dADP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103008", "l": "4-chloro-2-methylphenoxyacetate oxygenase activity"}, {"i": "MetaCyc:RXN-9864"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654409", "l": "Activated FGFR3 binds FRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71849", "l": "LDH tetramer reduces PYR to LACT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37910", "l": "(9Z)-octadecenoate + O2 <=> (8E,10S)-10-hydroperoxy-octadeca-8-enoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132060", "l": "Formation of C5b:C6:C7 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51548", "l": "(R)-tetrahydropapaverine + S-adenosyl-L-methionine = (R)-N-methyltetrahydropapaverine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5334794", "l": "FABPs bind LCFAs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624954", "l": "INPP5E translocates to the primary cilium (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33686", "l": "H(+) + L-serine + octadecanoyl-CoA <=> 3-oxoeicosasphinganine + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417898", "l": "P2Y4 receptor can bind to UTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19688", "l": "(E)-feruloyl-CoA + tyramine <=> CoA + H(+) + N-[(E)-feruloyl]tyramine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50286", "l": "(12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612444", "l": "ERBB4s80 binds STMN1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56867", "l": "12 H(+) + 6 malonyl-CoA + NADH + 5 NADPH <=> (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + 6 CoA + 4 H2O + NAD(+) + 5 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047868", "l": "dimethylmaleate hydratase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990472", "l": "piRNA dual-strand cluster binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163320", "l": "Association of mTERF with the termination sequence (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16499", "l": "H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine => adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40297", "l": "AMP + diphosphate + hexadecanedioyl-CoA => ATP + CoA + hexadecanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5228992", "l": "ROCK1,ROCK2 are activated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788867", "l": "FN3K phosphorylates ketosamines (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674140", "l": "PAQR3 binds inactive RAFs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53025", "l": "a plastoquinone + H2O + L-arginine => 5-guanidino-2-oxopentanoate + a plastoquinol + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9680443", "l": "ROCK1,2 bind ROCKi (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47555", "l": "glycodeoxycholate + H2O <=> deoxycholate + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672817", "l": "Active MTORC1 binds the ULK1 complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53575", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5686430", "l": "MUS81 binds EME1, EME2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47246", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+) => (2R)-3-phosphoglycerate + an NDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1964496", "l": "STING binds TRIM32 or TRIM56  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210444", "l": "L-Glutamate loading of synaptic vesicle (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24307", "l": "glycine + H(+) + N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] <=> (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29181", "l": "a menaquinone + 2 H(+) + 2 superoxide => a menaquinol + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-182986", "l": "CBL-mediated ubiquitination of CIN85 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717205", "l": "GNB1,3:GNG13:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.52"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15198", "l": "a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine => an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61387", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O <=> 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36774", "l": "beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-beta-L-fucose <=> alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41416", "l": "1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dioctanoyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0016778", "l": "diphosphotransferase activity"}, {"i": "EC:2.7.6.-", "l": "\"Diphosphotransferases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936380", "l": "Interaction of PIN1 with p-IRF3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61556", "l": "gibberellin A12 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = gibberellin A15 + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12617", "l": "ATP + N-acetyl-alpha-D-galactosamine = ADP + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate"}, {"i": "EC:2.7.1.157", "l": "\"N-acetylgalactosamine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.13", "l": "\"IgA-specific metalloendopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977626", "l": "C4b-binding protein binds C4b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64470", "l": "4-methylsulfanyl-2-oxobutanoate + H(+) + NADPH => (2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102318", "l": "2-deoxystreptamine glucosyltransferase activity"}, {"i": "MetaCyc:RXN-13121"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13932", "l": "agmatine + H2O <=> putrescine + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874979", "l": "ACBD3 binds GOLGB1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47342", "l": "6beta-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41588", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "57.594505980001507", "identifiers": [{"i": "GO:0004888", "l": "transmembrane signaling receptor activity"}, {"i": "REACT:R-HSA-193672", "l": "Sphingomyelinase is activated by the NGF:p75NTR complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28643", "l": "(2E,6E)-farnesyl diphosphate = alpha-zingiberene + diphosphate"}, {"i": "EC:4.2.3.65", "l": "\"Zingiberene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20945", "l": "S-adenosyl-L-methionine + theobromine => caffeine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9010872", "l": "SLIT2 binds Dystroglycan (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707690", "l": "BACH1 binds MAFK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047968", "l": "glyoxylate dehydrogenase (acylating) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41540", "l": "8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + S-adenosyl-L-methionine = 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.305", "l": "\"8-demethyl-8-alpha-L-rhamnosyl tetracenomycin-C 2'-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17790", "l": "(S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine => (S)-reticuline + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814096", "l": "ARL1:GTP binds SCOC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6811412", "l": "Active ARF recruits coatomer to the Golgi (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1222376", "l": "NOX2 generates superoxide from oxygen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26531", "l": "4-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016987", "l": "sigma factor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902098", "l": "calcitriol binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47026", "l": "[DsrC protein]-S-sulfo-L-cysteine/L-cysteine + 3 AH2 + H(+) => [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709098", "l": "DHFR dimer reduces FOLA to DHF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64896", "l": "2 H2O + UTP = 2 H(+) + 2 phosphate + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662904", "l": "CD isomers transform to BT, BTCA, BZ, ODHBT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190065", "l": "Activated TrkA receptor internalizes to endosomes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4167501", "l": "An unknown protease degrades ACACB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0016412", "l": "serine O-acyltransferase activity"}, {"i": "RHEA:24560", "l": "acetyl-CoA + L-serine = CoA + O-acetyl-L-serine"}, {"i": "EC:2.3.1.30", "l": "\"Serine O-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15081", "l": "acetate + ATP + CoA = acetyl-CoA + ADP + phosphate"}, {"i": "RHEA:29843", "l": "ATP + CoA + propanoate = ADP + phosphate + propanoyl-CoA"}, {"i": "EC:6.2.1.13", "l": "\"Acetate--CoA ligase (ADP-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37603", "l": "(11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73757", "l": "Binding of RRN3 to RNA Polymerase I (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70982", "l": "Fumarate + H2O <=> (S)-Malate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0031890", "l": "vasoactive intestinal polypeptide receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209921", "l": "Monoiodinated tyrosine can be deiodinated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25304", "l": "7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+) => 7,8-dihydroneopterin 3'-triphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854209", "l": "TBC1D10A binds JFC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-378952", "l": "Thyrotropin is a heterodimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801666", "l": "PLK2 phosphorylates CENPJ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61775", "l": "rebaudioside E + UDP-alpha-D-glucose <=> H(+) + rebaudioside D + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30547", "l": "(3S)-hydroxyhexanoyl-CoA = (2E)-hexenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48969", "l": "[thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2 => [thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49305", "l": "a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389354", "l": "Activation of Vav1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50453", "l": "prostaglandin H3 => prostaglandin E3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11351", "l": "arsenite(in) + ATP + H2O <=> ADP + arsenite(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017507", "l": "RHOJ binds effectors at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15949", "l": "(R)-2-hydroxyoctadecanoate + NAD(+) = 2-oxodecanoate + H(+) + NADH"}, {"i": "EC:1.1.1.98", "l": "\"(R)-2-hydroxy-fatty-acid dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877281", "l": "PIAS1 binds p-STAT1 dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707523", "l": "Hemes bind to BACH1:MAFK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32539", "l": "(2E)-geranyl diphosphate = (+)-car-3-ene + diphosphate"}, {"i": "EC:4.2.3.107", "l": "\"(+)-car-3-ene synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070740", "l": "tubulin-glutamic acid ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16858", "l": "a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine => an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26326", "l": "(8Z,11Z)-5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine => (8Z,11Z)-5-(pentadeca- 8,11,14-trien-1-yl)resorcinol-3-methyl ether + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928657", "l": "MMP2,9 cleave EPHB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102831", "l": "stachyose synthase activity"}, {"i": "MetaCyc:RXN-8287"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42574", "l": "2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + CO2 => 3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.70", "l": "\"Aculeacin-A deacylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44148", "l": "L-lysine = D-beta-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11911", "l": "H2O + nonane-4,6-dione <=> butanoate + H(+) + pentan-2-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66202", "l": "(2E)-pentenoyl-CoA + H2O2 => O2 + pentanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59225", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + hydropyrene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59526", "l": "9-O-10-oxo-(12Z)-octadecenoate L-aspartatyl ester-[protein] => 9S,10-epoxy-(10,12Z)-octadecadienoate + H(+) + L-aspartyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63222", "l": "5'-deoxyadenosine + archaeosine(15) in tRNA + 2 H(+) + L-1-piperideine-6-carboxylate + L-methionine => 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47193", "l": "[methyl-Co(III) methylated-thiol-specific corrinoid protein] + coenzyme M => [Co(I) methylated-thiol-specific corrinoid protein] + H(+) + methyl-coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30405", "l": "Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in) => Fe(3+)(out) + L-ascorbate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047441", "l": "5-dehydro-2-deoxyphosphogluconate aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60828", "l": "a 5'-end triphospho-adenosine in mRNA + H2O = a 5'-end diphospho-adenosine in mRNA + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24800", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O <=> (S)-2-amino-6-oxoheptanedioate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050585", "l": "4-hydroxymandelate synthase activity"}, {"i": "MetaCyc:1.13.11.46-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50030", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + tetradecanoyl-4'-phosphopantetheine => H2O + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047823", "l": "D-glutamyltransferase activity"}, {"i": "RHEA:35623", "l": "D-glutamate + D-glutamine = D-gamma-glutamyl-D-glutamate + NH4(+)"}, {"i": "EC:2.3.2.1", "l": "\"D-glutamyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51075", "l": "a phenol + a phenyl sulfate <=> a phenol + a phenyl sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610720", "l": "PKA phosphorylates GLI3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007462", "l": "CDC7 gene expression is repressed by the PRC1L4 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42631", "l": "S-adenosyl-L-methionine + uridine(747) in 23S rRNA <=> 5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426209", "l": "DAG activation of TRPC channels (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-83788", "l": "Binding of TFIIIC to Type 2 promoter (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1834939", "l": "STING recruits TBK1 and IRF3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001608", "l": "G protein-coupled nucleotide receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0046583", "l": "cation efflux transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351876", "l": "Caspase-mediated cleavage of occludin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57442", "l": "2-hydroxytoluene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => 2-methylanisole + O2 + reduced [NADH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18551", "l": "[(1->4)-alpha-D-glucosyl](n+1) + H(+) + UDP => [(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.7.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40307", "l": "A + decanedioyl-CoA = (2E)-decenedioyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18523", "l": "2'-O-methyllicodione + H(+) + S-adenosyl-L-homocysteine => licodione + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848818", "l": "PTK6 phosphorylates CBL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51407", "l": "H2O + L-arginine + O2 <=> 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32770", "l": "cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(4) in tRNA(Pro) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047807", "l": "cytokinin 7-beta-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617758", "l": "EP300,CREBBP acetylate FOXO4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66147", "l": "5-methoxytryptamine + acetyl-CoA <=> CoA + H(+) + melatonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33823", "l": "3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvate + H(+) + NADH = NAD(+) + tetrahydro-4-hydroxyphenylpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697064", "l": "lprG binds to LAM,LM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34779", "l": "a 3alpha-hydroxysteroid + NAD(+) = a 3-oxosteroid + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47458", "l": "3-oxo-(5Z-tetradecenoyl)-CoA + H(+) + NADH => (3S)-hydroxy-(5Z-tetradecenoyl)-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5678327", "l": "MIOX oxidises Ins to GlcA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38933", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + L-serine => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12706", "l": "[protein]-L-beta-isoaspartate + S-adenosyl-L-methionine => [protein]-L-beta-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31318", "l": "(2R)-3-phosphoglycerate + GDP-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41268", "l": "H2O + N-(15Z-tetracosenoyl)-sphing-4-enine => (15Z)-tetracosenoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158278", "l": "factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450387", "l": "HuR binds the CRM1 nuclear export machinery (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52452", "l": "16alpha-hydroxyestrone + UDP-alpha-D-glucuronate = 16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27704", "l": "keto-D-tagaturonate => aldehydo-D-galacturonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421831", "l": "trans-Golgi Network Coat Assembly (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66799", "l": "miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 11-oxomiltiradiene + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33130", "l": "H2O + salicin-6-phosphate <=> beta-D-glucose 6-phosphate + salicyl alcohol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.39"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28757", "l": "a ubiquinol + dihydroxyacetone phosphate => a ubiquinone + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851933", "l": "MET phosphorylates GAB1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29279", "l": "H(+) + menaquinol-8 + trimethylamine N-oxide = H2O + menaquinone-8 + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32825", "l": "phosphate(out) => phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0140318", "l": "protein transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102521", "l": "tRNA-4-demethylwyosine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209924", "l": "Dopa is decarboxylated to dopamine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62444", "l": "L-canavanine + L-ornithine = H(+) + L-arginine + L-canaline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15203", "l": "6-methoxymellein + H(+) + S-adenosyl-L-homocysteine => 6-hydroxymellein + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59982", "l": "8-oxo-dGDP + H(+) + phosphate => 8-oxo-dGTP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102939", "l": "3-methoxy-5-hydroxytoluene O-methyltransferase activity"}, {"i": "MetaCyc:RXN-9018"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16667", "l": "(5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate => (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45179", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39387", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA = (2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209738", "l": "VD3 binds GC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140338", "l": "sphingomyelin transfer activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11077", "l": "anthranilate + 3 H(+) + NADH + O2 => catechol + CO2 + NAD(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008868", "l": "galactitol-1-phosphate 5-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61582", "l": "(5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH => (3S)-3-hydroxycyclohexane-1-carbonyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53873", "l": "CTP + D-ribose 5-phosphate + H(+) => CDP-D-ribose + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11493", "l": "H(+) + O-phospho-L-threonine => (R)-1-aminopropan-2-yl phosphate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23699", "l": "myo-inositol + O2 <=> D-glucuronate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34044", "l": "5-phospho-alpha-D-ribose 1-diphosphate + neamine => 5''-phosphoribostamycin + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22968", "l": "butanal + CoA + NAD(+) = butanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783883", "l": "P6C transforms to 2AMAS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199910", "l": "MSK1 activates ATF1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67026", "l": "a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15519", "l": "H(+) + N-sulfo-D-glucosamine + sulfate => H2O + N(2),6-disulfo-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42610", "l": "a plastoquinol + n H(+)(out) + NAD(+) => a plastoquinone + (n+1) H(+)(in) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42219", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067667", "l": "IL6 binds IL6R (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38133", "l": "1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65305", "l": "2-oxoglutarate + O2 + verruculide A => chrodrimanin T + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008822", "l": "PPM1D dephosphorylates RUNX2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44858", "l": "CoA + O-(9Z)-octadecenoyl-(R)-carnitine => (9Z)-octadecenoyl-CoA + (R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56723", "l": "2 [Fe(III)cytochrome c] + L-cysteinyl-[SoxY protein] + thiosulfate <=> 2 [Fe(II)cytochrome c] + 2 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22961", "l": "formononetin + O2 + reduced [NADPH--hemoprotein reductase] => calycosin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694542", "l": "nsp14 binds nsp10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25872", "l": "H2O2 + pyridine = H2O + pyridine N-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20627", "l": "2 [Fe(II)-cytochrome c3] + 2 H(+) => 2 [Fe(III)-cytochrome c3] + H2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34301", "l": "2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate => 2'-deamino-2'-hydroxyneamine + 2-oxoglutarate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047536", "l": "2-aminoadipate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36922", "l": "(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045510", "l": "interleukin-24 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40226", "l": "4,8-dimethylnonanoyl-CoA + H2O <=> 4,8-dimethylnonanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641147", "l": "DACT1 binds DVL2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004749", "l": "ribose phosphate diphosphokinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5658435", "l": "RAS GAPs bind RAS:GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27756", "l": "(R)-lactate + H(+) => H2O + methylglyoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55452", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = daturadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.64", "l": "\"Beta-amyrin 6-beta-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10166", "l": "H2O + phosphoenolpyruvate => (2R)-2-phosphoglycerate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55713", "l": "(S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O => (9Z)-octadecenoate + (S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218822", "l": "CRK binds BCAR1 and or PXN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655844", "l": "Expression of Squalene Monooxygenase (SQLE) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877918", "l": "RUNX2:MAF complex binds the BGLAP gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211164", "l": "AKT phosphorylates FOXO1A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651809", "l": "LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21677", "l": "2 dimethylallyl diphosphate => (R)-lavandulyl diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14994", "l": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH => a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53209", "l": "daidzein + O2 + reduced [NADPH--hemoprotein reductase] => 2'-hydroxydaidzein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64433", "l": "H(+)(out) + L-alanyl-L-prolylglycine(out) => H(+)(in) + L-alanyl-L-prolylglycine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13686", "l": "5alpha-cholest-7-en-3beta-ol + NADP(+) => 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49938", "l": "5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873929", "l": "Casein kinase II phosphorylates STARD10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351876", "l": "Caspase-mediated cleavage of occludin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47732", "l": "cytidine(1400) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1400) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48646", "l": "(12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde => prostaglandin H2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57089", "l": "an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O => 3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071576", "l": "tetrahydrodictyopterin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57113", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55242", "l": "(9Z)-octadecenoate + 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H(+) => 1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011748", "l": "IL9R binds JAK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47735", "l": "cytidine(1400) in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(1400) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9670014", "l": "Factor VIIIa dissociates  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45313", "l": "NADP(+) + prostaglandin F2alpha => H(+) + NADPH + prostaglandin H2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16352", "l": "AH2 + chlorate <=> A + chlorite + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007522", "l": "E2F6 binds APAF1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102776", "l": "UDP-D-glucose:pelargonidin-3-O-beta-D-glucoside 5-O-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-7828"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170978", "l": "p-FRS2:CRKL binds C3G (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202248", "l": "Phosphorylation of PLC-gamma1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20904", "l": "(2S)-2-hydroxypropyl-coenzyme M = (S)-1,2-epoxypropane + coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54177", "l": "a long-chain fatty aldehyde + holo-[ACP] + NADP(+) => a long-chain fatty acyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001070", "l": "RNA-binding transcription regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110322", "l": "Formation of Pol zeta complex (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73577", "l": "CAD hexamer transforms L-Gln to CAP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418172", "l": "F2R binds ARRB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59335", "l": "1'-hydroxy-gamma-carotene + A <=> 1'-hydroxytorulene + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40235", "l": "coenzyme B + coenzyme M + fumarate = coenzyme M-coenzyme B heterodisulfide + succinate"}, {"i": "EC:1.3.4.1", "l": "\"Fumarate reductase (CoM/CoB)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030622", "l": "U4atac snRNA binding"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0016918", "l": "retinal binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36075", "l": "AH2 + an N-acylsphinganine + O2 = A + an N-acylsphing-4-enine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-164834", "l": "Enzyme-bound ATP is released (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159771", "l": "Furin cleaves pro-protein C to protein C (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799350", "l": "Exocytosis of specific granule membrane proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018651", "l": "toluene-4-sulfonate monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189439", "l": "ALAD condenses 2 dALAs to form PBG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33390", "l": "cadaverine + S-adenosyl 3-(methylsulfanyl)propylamine <=> aminopropylcadaverine + H(+) + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10211", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) <=> H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858475", "l": "TNFSF9 binds TNFRSF9 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399930", "l": "Activation of PAK by Rac1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15439", "l": "a long-chain fatty acyl-CoA + H(+) + NADPH => a long-chain fatty aldehyde + CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36696", "l": "dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid => desmethyldescarbamoylnovobiocin + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66510", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 [Fe(III)-cytochrome b5] + 2 H2O => 1-(9Z,12Z-octadecadienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58820", "l": "H(+) + malonate + Na(+)(in) = acetate + CO2 + Na(+)(out)"}, {"i": "EC:7.2.4.4", "l": "\"Biotin-dependent malonate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9609310", "l": "β-blockers bind ADRB1,2,3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16465", "l": "(R)-lactate + 2 [Fe(III)cytochrome c553] = 2 [Fe(II)cytochrome c553] + 2 H(+) + pyruvate"}, {"i": "EC:1.1.2.5", "l": "\"D-lactate dehydrogenase (cytochrome c-553)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3296309", "l": "HCAR3 binds HCAR3 ligands (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39478", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA <=> (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784620", "l": "MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63648", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75172", "l": "Formation of RAD50:MRE11 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.-", "l": "\"Dipeptide hydrolases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53886", "l": "alpha,alpha-trehalose 6-phosphate + CDP + H(+) => CDP-alpha-D-glucose + D-glucose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665982", "l": "RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60947", "l": "quercetin + S-adenosyl-L-methionine <=> H(+) + isorhamnetin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429860", "l": "DCP1-DCP2 complex decaps mRNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61555", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> gibberellin A12 aldehyde + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158399", "l": "kallikrein binds SERPING1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35563", "l": "H2O + N-(9Z-hexadecenoyl) ethanolamine = (9Z)-hexadecenoate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11690", "l": "AMP + diphosphate + L-leucyl-tRNA(Leu) => ATP + L-leucine + tRNA(Leu)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189406", "l": "4 PBGs bind to form HMB (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39455", "l": "(2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + NADPH = (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015565", "l": "threonine efflux transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21204", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol = a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester"}, {"i": "EC:2.3.1.43", "l": "\"Phosphatidylcholine--sterol O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59919", "l": "(2E)-octenal + H2O + NADP(+) <=> (2E)-octenoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41173", "l": "2-hexadecenoyl-sn-glycero-3-phosphate + a fatty acid + H(+) => 1-acyl-2-hexadecenoyl-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174124", "l": "Dephosphorylation of phospho-Cdh1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41457", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47562", "l": "CMP + ganglioside GM1b (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E))"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29598", "l": "CoA + NADP(+) + sulfoacetaldehyde <=> H(+) + NADPH + sulfoacetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23486", "l": "AH2 + D-cellobiono-1,5-lactone => A + D-cellobiose"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0008907", "l": "integrase activity"}, {"i": "REACT:R-HSA-164523", "l": "Transesterification to connect viral DNA 3' ends to host DNA 5' ends (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20322", "l": "L-proline + NAD(+) => 1-pyrroline-2-carboxylate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389762", "l": "Phosphorylation of PD-1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374173", "l": "AGT(34-41) binds to AGTR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21498", "l": "diphosphate + prenol => dimethylallyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42033", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66829", "l": "2 ATP + 2 cob(II)alamin + 2 H2O + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)alamin + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51640", "l": "(9Z,12Z)-octadecadienoate + O2 = (11R)-hydroperoxy-(9Z,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64702", "l": "acetophenone + H(+) + NADH => 1-phenylethanol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56524", "l": "A + dihydro-heme d1 = AH2 + heme d1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15300", "l": "3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose <=> 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-213407", "l": "Disassociation of PLC-gamma1 from SLP-76 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159005", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702629", "l": "sunitinib-resistant FLT3 mutants don't bind sunitinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198714", "l": "ERK5 translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46318", "l": "2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H(+) => GDP-N,N'-diacetylbacillosamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30434", "l": "(S)-2,3-epoxysqualene <=> taraxerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63309", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 11-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47256", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32105", "l": "2 H(+) + pterostilbene + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + trans-resveratrol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45241", "l": "a (3E,5Z)-dienoyl-CoA => a (2E,4E)-(5,6-saturated)-dienoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23920", "l": "(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32681", "l": "(2E)-geraniol + diphosphate => (2E)-geranyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64395", "l": "a dipeptide(out) + H(+)(out) <=> a dipeptide(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48289", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM3 => CMP + ganglioside GD3 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64938", "l": "dGDP + H(+) + phosphate => dGTP + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004324", "l": "ferredoxin-NADP+ reductase activity"}, {"i": "MetaCyc:1.18.1.2-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682011", "l": "LC3 binds ATG7 dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186819", "l": "SH2 domain of Src binds to the active receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112510", "l": "IL6ST is tyrosine phosphorylated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32130", "l": "2-oxoglutarate + L-proline + O2 <=> cis-4-hydroxy-L-proline + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17831", "l": "AH2 + CO2 => A + CO + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109860", "l": "MAP2K1 phosphorylates MAPK3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-182594", "l": "Association of INK4 family proteins with CDK4/6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51176", "l": "cytidine(48) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(48) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871373", "l": "BMX phosphorylates RUFY1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74885", "l": "GUCYs converts GTP to cGMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236968", "l": "Egress of internalized antigen into cytosol from early endosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37409", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3777129", "l": "HDAC3 containing complexes deacetylate histone (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018544", "l": "4-carboxy-4'-sulfoazobenzene reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62829", "l": "GDP-beta-L-fucose + methyl-8-{[beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211247", "l": "Cleavage of DNA by DFF40 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021364", "l": "ELF3 binds NOTCH3 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37521", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021520", "l": "NOTCH3 binds WWP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63444", "l": "(2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin = GMP + H(+) + oxidized coenzyme F420-0"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29522", "l": "alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158137", "l": "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10948", "l": "ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65630", "l": "CoA + H(+) + N-tetracosanoylsphinga-(4E,8Z)-dienine => sphinga-(4E,8Z)-dienine + tetracosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34841", "l": "5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO2 + 5 CoA + H2O => 4 H(+) + 5 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141437", "l": "Formation of the MCC complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56991", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5138432", "l": "DVL2 is phosphorylated by PKC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004359", "l": "glutaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875591", "l": "DOCK7 activates RAC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58040", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + H2O = (9Z,12Z,15Z)-octadecatrienoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047391", "l": "alkylglycerophosphoethanolamine phosphodiesterase activity"}, {"i": "MetaCyc:3.1.4.39-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15271", "l": "H(+) + L-ascorbate => L-xylo-hex-3-ulonolactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45900", "l": "a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983426", "l": "Capturing cargo and formation of prebudding complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21759", "l": "deacetylisoipecoside + H2O <=> dopamine + secologanin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433501", "l": "Interaction of other adapter proteins with p-KIT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030743", "l": "rRNA (adenosine-2'-O-)-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416725", "l": "SEMA6D binds to PLXNA1:TREM2:DAP12 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.44", "l": "\"Lipopolysaccharide 3-alpha-galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372542", "l": "Loading of dopamine into synaptic veiscles (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685604", "l": "SLAMF6 binds SLAMF6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62745", "l": "H2O + mevastatin => (S)-2-methylbutanoate + compactin diol lactone + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218824", "l": "p-6Y-VEGFR2 binds FYN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49372", "l": "H(+) + NADH + O2 + protodeoxyviolaceinate = H2O + NAD(+) + protoviolaceinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863858", "l": "SEC22B, CALR, STX4, TAP and TAPBP bind (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647660", "l": "GSDME (1-270) binds PIPs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24731", "l": "anthranilate + H(+) => aniline + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52413", "l": "4-phospho-D-erythronate + NAD(+) => 3-dehydro-4-O-phospho-D-erythronate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102840", "l": "1-18:2-2-16:3-monogalactosyldiacylglycerol desaturase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008119", "l": "thiopurine S-methyltransferase activity"}, {"i": "MetaCyc:THIOPURINE-S-METHYLTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19909", "l": "(S)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H(+) + pyruvate"}, {"i": "EC:1.1.2.3", "l": "\"L-lactate dehydrogenase (cytochrome)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25456", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + gamma-humulene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157629", "l": "NOTCH2-ligand complex is cleaved to produce NEXT2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9733973", "l": "Bile salts bind FABP6 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70494", "l": "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61366", "l": "3beta-sulfooxy-androst-5-en-17-one(out) + ADP + H(+) + phosphate => 3beta-sulfooxy-androst-5-en-17-one(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380780", "l": "Activation of Src (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198508", "l": "malate + NAD+ <=> oxaloacetate + NADH + H+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46798", "l": "2 [Fe(III)-cytochrome b5] + an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 H2O => 2 [Fe(II)-cytochrome b5] + an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423656", "l": "AFXBO hydrolyses non-enzymatically to AFBDHD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036202", "l": "ent-cassa-12,15-diene 11-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183072", "l": "EGFR non-clathrin mediated endocytosis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67086", "l": "ADP + H(+) + hexacosanoate(out) + phosphate => ATP + H2O + hexacosanoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198714", "l": "ERK5 translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44809", "l": "1,4-dihydroxy-2-naphthoate + all-trans-decaprenyl diphosphate + H(+) => 2-demethylmenaquinol-10 + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33008", "l": "(+)-artemisinic alcohol + O2 + reduced [NADPH--hemoprotein reductase] => (+)-artemisinic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5220959", "l": "TDG excises 5-formylcytosine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22709", "l": "H2O + S-acylglutathione => a carboxylate + glutathione + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015227", "l": "acyl carnitine transmembrane transporter activity"}, {"i": "REACT:R-HSA-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43061", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate => beta-D-glucose 1-phosphate + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944232", "l": "Association of procollagen type XII (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-379387", "l": "COMT transfers Met to DA to form 3MT (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2032775", "l": "YAP1 binds TEAD1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0003678", "l": "DNA helicase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182594", "l": "Association of INK4 family proteins with CDK4/6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13187", "l": "hydroxymethylbilane + 4 NH4(+) => H2O + 4 porphobilinogen"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10805", "l": "(S)-allantoin => (R)-allantoin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209840", "l": "Two DITs combine to form thyroxine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64048", "l": "(13Z)-docosenoyl-CoA + sphinganine = CoA + H(+) + N-(13Z-docosenoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37767", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964759", "l": "Alternative endo-mannosidase I route (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000319", "l": "BORA binds PLK1 and AURKA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50567", "l": "acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38224", "l": "(9Z)-octadecenoyl-CoA + decan-1-ol => 1-O-decyl-(9Z)-octadecenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990422", "l": "glyoxalase (glycolic acid-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65357", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + ATP => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24039", "l": "a ribonucleoside 5'-phosphate + ATP <=> a ribonucleoside 5'-diphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949335", "l": "RUNX3:CBFB binds the ITGAL gene,(ITGA4 gene) promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52829", "l": "(1S,4R)-isodihydrocarvone + H(+) + NADPH + O2 => (3S,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3221843", "l": "MSR1 (SCARA1) binds collagen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56958", "l": "H(+) + IDP + phosphoenolpyruvate => ITP + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52899", "l": "2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin <=> 2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30500", "l": "H(+) + N,N-dihydroxy-L-valine => (E)-2-methylpropanal oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74734", "l": "Re-integration of insulin receptor into plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809707", "l": "MTMR12 binds MTMR2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55072", "l": "2-oxobutanoate + H(+) = CO2 + propanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165131", "l": "GEF dissociates from DRheb-GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36644", "l": "emodin + S-adenosyl-L-methionine => H(+) + questin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38668", "l": "sphing-4-enine 1-phosphate(in) => sphing-4-enine 1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13417", "l": "5,12-dihydroxanthommatin + NAD(+) = H(+) + NADH + xanthommatin"}, {"i": "EC:1.3.1.41", "l": "\"Xanthommatin reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937034", "l": "IRAK1 phosphorylates Pellino (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0032028", "l": "myosin head/neck binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635868", "l": "ub-GLI is degraded by the proteasome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033981", "l": "D-dopachrome decarboxylase activity"}, {"i": "RHEA:18441", "l": "D-dopachrome + H(+) = 5,6-dihydroxyindole + CO2"}, {"i": "EC:4.1.1.84", "l": "\"D-dopachrome decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017162", "l": "aryl hydrocarbon receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210277", "l": "Interaction of PECAM-1 and SHP-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47487", "l": "deoxycholate + NAD(+) <=> 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27524", "l": "H(+) + N-formylmaleamate => 2,5-dihydroxypyridine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21874", "l": "H(+) + N(omega)-methyl-L-arginyl-[cytochrome c] + S-adenosyl-L-homocysteine => L-arginyl-[cytochrome c] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936599", "l": "RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the GP1BA promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14711", "l": "a 3-oxo-Delta(4)-steroid => a 3-oxo-Delta(5)-steroid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10415", "l": "ADP-D-ribose + H2O <=> AMP + D-ribose 5-phosphate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1504188", "l": "FZD recruits DVL to the receptor complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340385", "l": "HAVCR2 binds LGALS9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44179", "l": "a 2,3-diacyl-sn-glycerol + H2O <=> 3-acyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852306", "l": "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55949", "l": "A + D-alanine + H2O => AH2 + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168915", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176956", "l": "Formation of GINS complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141159", "l": "TNF-mediated dimerization of procaspase-8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25706", "l": "H(+) + N,N-dihydroxy-L-dihomomethionine = (E)-5-(methylsulfanyl)pentanal oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159001", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018461", "l": "fluoren-9-ol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31307", "l": "alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate = alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}, {"i": "EC:2.4.1.265", "l": "\"Dolichyl-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57724", "l": "H(+) + 2 Na(+)(in) + oxaloacetate = CO2 + 2 Na(+)(out) + pyruvate"}, {"i": "EC:7.2.4.2", "l": "\"Oxaloacetate decarboxylase (Na(+) extruding)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418172", "l": "F2R binds ARRB2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60405", "l": "Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) + H2O => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(2,3-dihydroxybenzoyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38811", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391152", "l": "p-4Y-SIRPA:CD47 binds PTK2B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29878", "l": "H2O + sn-glycero-3-phospho-L-serine <=> H(+) + L-serine + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61603", "l": "[DsbD protein]-disulfide + [protein]-dithiol <=> [DsbB protein]-dithiol + [protein]-disulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54040", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (3E,7E)-dolathalia-3,7,11-triene + diphosphate"}, {"i": "EC:4.2.3.168", "l": "\"Dolathalia-3,7,11-triene synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004663", "l": "Rab geranylgeranyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034043", "l": "5-hydroxymethyluracil DNA N-glycosylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168869", "l": "Budding of vesicle with the HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum into the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59680", "l": "D-maltopentaose + O2 = D-maltopentaono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6791235", "l": "GADD45A binds AURKA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.64", "l": "\"E1 NEDD8-activating enzyme\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14824", "l": "L-arabinose <=> L-ribulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140132", "l": "iron-sulfur cluster carrier activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55186", "l": "2-hydroxy-3-methylundecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methylundecanoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709360", "l": "H2O2 reduces MetHb (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2247511", "l": "STAB2:ligand is endocytosed (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56994", "l": "(+)-costunolide + H2O => 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19206", "l": "dCTP + 2 H2O => diphosphate + dUMP + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374298", "l": "Opioid receptors bind opioid peptides (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1454916", "l": "The ABCC family mediates organic anion transport (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45829", "l": "(3R)-hydroxyhexanoyl-CoA + NAD(+) => 3-oxohexanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55267", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine <=> di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51292", "l": "a quinone + H2O + L-methionyl-[protein] = a quinol + L-methionyl-(S)-S-oxide-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20867", "l": "alpha,alpha-trehalose 6-phosphate + phosphate <=> beta-D-glucose 1-phosphate + D-glucose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0033328", "l": "peroxisome membrane targeting sequence binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57083", "l": "glutathione + S-methyl-1-thio-D-xylulose 5-phosphate <=> 1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432054", "l": "Aquaporin-1 passively transports water out of cell (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53061", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate => estrone 4-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30797", "l": "CO2 + glutaryl-CoA + NADH => 2-oxoadipate + CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41818", "l": "ganglioside GD2 (d18:1(4E)) + H(+) + UDP => ganglioside GD3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58851", "l": "(6E)-8-hydroxygeraniol + NAD(+) <=> (6E)-8-hydroxygeranial + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433418", "l": "Phosphorylation of JAK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46974", "l": "AH2 + bisanhydrobacterioruberin => A + dihydrobisanhydrobacterioruberin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31748", "l": "3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + H2O + NADP(+) => 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791363", "l": "TP53 stimulates ARID3A gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27850", "l": "glycine + phenylacetyl-CoA = CoA + H(+) + phenylacetylglycine"}, {"i": "EC:2.3.1.192", "l": "\"Glycine N-phenylacetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102918", "l": "(R)-reticuline 7-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-8701"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44392", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-heptadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58409", "l": "NADP(+) + undecan-1-ol => H(+) + NADPH + undecanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52604", "l": "3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-seryl-[protein] + ATP = 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-seryl-[protein] + ADP + H(+)"}, {"i": "RHEA:52616", "l": "3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + ATP = 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-threonyl-[protein] + ADP + H(+)"}, {"i": "EC:2.7.1.183", "l": "\"Glycoprotein-mannosyl O(6)-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27772", "l": "2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36481", "l": "(9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8979071", "l": "KDM6B binds iron (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32493", "l": "10-hydroxy-alpha-humulene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (1E,4E,8E)-alpha-humulene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50310", "l": "11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20300", "l": "an anilide + H2O <=> a carboxylate + aniline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69068", "l": "RFC dissociates after sliding clamp formation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22775", "l": "L-fuconate <=> 2-dehydro-3-deoxy-L-fuconate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20878", "l": "(E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein] => (R)-2-benzylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211239", "l": "Association of DFF40 with chromatin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11314", "l": "chloride + H(+) + hydroxyatrazine => atrazine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15318", "l": "a 2-deoxy-alpha-D-glucoside + H2O => 2-deoxy-D-glucose + an alcohol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47442", "l": "3-oxo-(7Z-hexadecenoyl)-CoA + H(+) + NADH => (3S)-hydroxy-(7Z-hexadecenoyl)-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54822", "l": "a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106145", "l": "scopoletin 8-hydroxylase activity"}, {"i": "RHEA:57848", "l": "2-oxoglutarate + O2 + scopoletin = CO2 + fraxetin + succinate"}, {"i": "EC:1.14.11.60", "l": "\"Scopoletin 8-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62935", "l": "H2O + N(4)-acetylcytidine <=> acetate + cytidine + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990053", "l": "DNA-5-methylcytosine glycosylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46104", "l": "21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = corticosterone + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49400", "l": "H2O + validoxylamine A 7'-phosphate = phosphate + validoxylamine A"}, {"i": "EC:3.1.3.101", "l": "\"Validoxylamine A 7'-phosphate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010465", "l": "nerve growth factor receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016361", "l": "activin receptor activity, type I"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5632652", "l": "Hh-Npp binds CDON and PTCH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111912", "l": "CaMK4 phosphorylates CREB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9670673", "l": "FIX is secreted (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000348", "l": "RANBP2 SUMOylates SP100 with SUMO2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000327", "l": "PLK1 phosphorylates BORA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451347", "l": "Activation of JNK by DSCAM (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42655", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine <=> diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45754", "l": "(2E)-decenoyl-CoA => (3E)-decenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14409", "l": "cysteamine + O2 = H(+) + hypotaurine"}, {"i": "EC:1.13.11.19", "l": "\"Cysteamine dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52711", "l": "GMP + H2O <=> D-ribose 5-phosphate + guanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679775", "l": "COMT binds COMT Inhibitors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061578", "l": "Lys63-specific deubiquitinase activity"}, {"i": "REACT:R-HSA-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58641", "l": "a 5'-(5'-phospho)-ribonucleoside-RNA + 2 S-adenosyl-L-methionine => a 5'-(5'-bisphosphomethyl)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8985950", "l": "p-Y649-STAT5A, p-STAT5B dimerizes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26067", "l": "ATP + hygromycin B <=> 4-O-phosphohygromycin B + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48886", "l": "3,8-divinyl protochlorophyllide a + H(+) + NADPH => NADP(+) + protochlorophyllide a"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.73", "l": "\"Adenosylcobalamin/alpha-ribazole phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63978", "l": "AH2 + pyriculariol => A + dihydropyriculariol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18555", "l": "dihydroxyfumarate + H(+) + NADH => (2R,3S)-tartrate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62676", "l": "10-formyldihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide = 6-thio-IMP + 7,8-dihydrofolate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654510", "l": "FGFRL1 binds SPRED1/2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17380", "l": "dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] <=> 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.281", "l": "\"GDP-4-dehydro-6-deoxy-D-mannose reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11275", "l": "a (2R)-2-hydroxycarboxylate + a quinone <=> a 2-oxocarboxylate + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805276", "l": "CDK5 phosphorylates TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917987", "l": "TFRC dimer binds 2xholoTF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57737", "l": "A + all-trans-3,4-didehydro-13,14-dihydroretinol => AH2 + all-trans-3,4-didehydroretinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852331", "l": "GTSE1 translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050105", "l": "L-gulonolactone oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65927", "l": "2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine <=> 2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050607", "l": "mycothiol-dependent formaldehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5681980", "l": "ATG12 binds ATG7 dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24382", "l": "(6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet) => (6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938328", "l": "RUNX1:CBFB binds the NFE2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0033207", "l": "beta-1,4-N-acetylgalactosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42249", "l": "butanoyl-CoA + H(+) + malonyl-[ACP] => 3-oxohexanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013435", "l": "RHOD auto-activates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28686", "l": "L-aspartate + ubiquinone-8 <=> iminosuccinate + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993898", "l": "VRK1/VRK2 phosphorylate BANF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416725", "l": "SEMA6D binds to PLXNA1:TREM2:DAP12 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035717", "l": "chemokine (C-C motif) ligand 7 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22762", "l": "CO2 + hnu + oxidized Cypridina luciferin => Cypridina luciferin + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3787997", "l": "Laminin-332 binds collagen type VII (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032931", "l": "histone acetyltransferase activity (H3-K56 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.15"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46322", "l": "3beta-hydroxy-chol-5,22-dien-24-oyl-CoA + AH2 => 3beta-hydroxy-chol-5-ene-24-oyl-CoA + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46799", "l": "2 [Fe(II)-cytochrome b5] + an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9734713", "l": "ORC6 translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55971", "l": "(+)-kolavelool + S-adenosyl-L-methionine <=> (+)-O-methylkolavelool + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72631", "l": "Formation of the cap-binding eIF4F complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12875", "l": "4-methyl-2-oxopentanoate + H(+) + NADPH => (R)-2-hydroxy-4-methylpentanoate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853792", "l": "RET tyrosine phosphorylation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736970", "l": "WWTR1:p-2S-SMAD2,3:SMAD4 binds SMAD7 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0001216", "l": "DNA-binding transcription activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8954117", "l": "E2F6:TFDP1 binds EPC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53441", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617471", "l": "HOXA1 gene is transcribed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22008", "l": "L-homoserine + succinyl-CoA = CoA + O-succinyl-L-homoserine"}, {"i": "EC:2.3.1.46", "l": "\"Homoserine O-succinyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15200", "l": "a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine <=> an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32234", "l": "(6S)-NADPHX + ATP <=> ADP + H(+) + NADPH + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51460", "l": "H2O + N-(9Z-octadecenoyl)-L-glutamate = (9Z)-octadecenoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48128", "l": "(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesyl phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183051", "l": "CBL ubiquitinates Sprouty (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694718", "l": "O-glycosylation of 3a is terminated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551727", "l": "CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18606", "l": "1-amino-1-deoxy-scyllo-inositol + ATP => 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62379", "l": "2,4-didehydro-3-deoxy-L-rhamnonate + H2O <=> (S)-lactate + H(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64603", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209336", "l": "Activated HOP is autophosphorylated and/or transphosphorylated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39884", "l": "dTDP-6-deoxy-alpha-D-allose + NADP(+) => dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018646", "l": "1-hydroxy-2-oxolimonene 1,2-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9656891", "l": "OPN1SW binds 11cRAL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9681375", "l": "KIT binds ripretinib (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014433", "l": "RHOG GEFs activate RHOG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57915", "l": "5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+) <=> H(+) + L-glutaminyl-tRNA(Gln) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54531", "l": "aldehydo-D-ribose 5-phosphate <=> D-ribose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018796", "l": "4,5-dihydroxyphthalate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13443", "l": "H(+) + NH4(+) + pyruvate + sulfite => H2O + L-cysteate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54207", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2 <=> 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201515", "l": "Active ALK recruits PI3K (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52321", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryptamine => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + serotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27987", "l": "hydroxyacetone + NADP(+) => H(+) + methylglyoxal + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179413", "l": "Activated PKC-alpha  activate MMP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11730", "l": "cyclopentanone + H(+) + NADH => cyclopentanol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203712", "l": "eNOS associates with Caveolin-1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419644", "l": "Transphosphorylation of pLIMK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602458", "l": "Activation of proMMP10 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.58", "l": "\"Heme oxygenase (biliverdin-IX-beta and delta-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51061", "l": "5alpha-androst-1-ene-3,17-dione + A => AH2 + androsta-1,4-diene-3,17-dione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11614", "l": "2-oxoglutarate + H(+) + NADPH + NH4(+) => H2O + L-glutamate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666008", "l": "SCAI binds SRF:MKL1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67112", "l": "L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24015", "l": "gamma-tocopherol + S-adenosyl-L-methionine <=> (+)-alpha-tocopherol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53040", "l": "4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15098", "l": "5-formimidoyltetrahydrofolate + L-glutamate => (6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374662", "l": "Translocation of Ezrin to plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23605", "l": "kievitone hydrate => H2O + kievitone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31745", "l": "a 4'-methoxyflavanone + H(+) + S-adenosyl-L-homocysteine => a 4'-hydroxyflavanone + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52871", "l": "17alpha-estradiol + UDP-alpha-D-glucuronate <=> 17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42153", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acyl-(4R)-4-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848864", "l": "PTK6 binds ARAP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23554", "l": "2-hydroxy-2-methylpropanal + H(+) + NADH => 2-methylpropane-1,2-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005094", "l": "Rho GDP-dissociation inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5679266", "l": "Beclin-1 complex translocates to the ER (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45191", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21166", "l": "a carboxylate + an alcohol + H(+) => a carboxylic ester + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10597", "l": "ATP + L-tyrosyl-[protein] => ADP + H(+) + O-phospho-L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34028", "l": "3,3'-bipyridine-2,2',5,5',6,6'-hexol + NADP(+) => (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15320", "l": "a 2-deoxy-alpha-D-glucoside + H2O <=> 2-deoxy-D-glucose + an alcohol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66126", "l": "(2S)-2-aminobutanoate + 3-(imidazol-5-yl)pyruvate => 2-oxobutanoate + L-histidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052934", "l": "alcohol dehydrogenase (cytochrome c) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444202", "l": "Receptor FFAR1 binds free fatty acids (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380176", "l": "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54125", "l": "coelenterazine h dioxetanone => CO2 + excited coelenteramide h monoanion + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58648", "l": "rifamycin SV hemiaminal = H(+) + rifamycin SV ortho-naphthoquinone carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619667", "l": "PRX gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52023", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 <=> A + H2O + resolvin E2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34016", "l": "ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2 => ergosterol + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63795", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O <=> C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46408", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004089", "l": "carbonate dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166792", "l": "Conversion of C2 into C2a and C2b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18382", "l": "dihydroxyacetone + phosphoenolpyruvate => dihydroxyacetone phosphate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674022", "l": "BRAP autoubiquitinates (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141691", "l": "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56137", "l": "2 a phenolic donor + H2O2 => 2 a phenolic radical donor + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9654533", "l": "KRAS4B recycles to the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27968", "l": "6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate => 7,8-dihydroneopterin 3'-triphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19375", "l": "2-oxoglutarate + H(+) + L-lysine + NADPH => H2O + L-saccharopine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5622129", "l": "FABP5 binds atRA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65632", "l": "a sphingoid base + tetracosanoyl-CoA = an N-tetracosanoyl-sphingoid base + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047802", "l": "cysteine-conjugate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141423", "l": "Binding of the MCC complex to the APC/C complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23299", "l": "N-acetylneuraminate <=> N-acetyl-D-mannosamine + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47658", "l": "CoA + H(+) + N-acetyl-L-methionine sulfone => acetyl-CoA + L-methionine sulfone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47327", "l": "(S)-3-amino-3-phenylpropanoate + pyruvate <=> 3-oxo-3-phenylpropanoate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396009", "l": "STING binds c-di-GMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20403", "l": "a substituted beta-amino acid => a beta-lactam + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804425", "l": "TP53 binds POU4F2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33749", "l": "a 1-acyl-sn-glycero-3-phosphate + ADP + H(+) => a 1-acyl-sn-glycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12643", "l": "3-phosphooxypyruvate + H(+) + NADH => (2R)-3-phosphoglycerate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13531", "l": "H2O + mesaconate => (3S)-citramalate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045029", "l": "G protein-coupled UDP receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213208", "l": "Type X collagen associates with collagen type II fibrils (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2396399", "l": "Fibrillins bind BMPs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13829", "l": "GDP-alpha-D-rhamnose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22618", "l": "2 (2R)-bisdechlorogeodin + 2 H2O => 2 H(+) + O2 + 2 sulochrin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36165", "l": "ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432143", "l": "PECAM-1 binds PP2A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-555065", "l": "Formation of clathrin coated vesicle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615571", "l": "PTEN mRNA translation is inhibited by miR-137 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59509", "l": "fumarate + L-cysteinyl-[protein] => S-(2-succinyl)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31760", "l": "dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine => dTDP-alpha-D-desosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13890", "l": "FAD + H2O => AMP + FMN + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033845", "l": "hydroxymethylfurfural reductase (NADPH) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50122", "l": "CoA + H(+) + N-tetracosanoyl-taurine => taurine + tetracosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012689", "l": "IL37(1-?) and IL37 (?-) dissocates from IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623643", "l": "RDH13 reduces atRAL to atROL (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784204", "l": "JAKs bind OSMR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22997", "l": "H2O2 + L-ascorbate => 2 H2O + L-dehydroascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446694", "l": "IRAK4 phosphorylates IRAK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.19"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030787", "l": "inositol 4-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111962", "l": "PDE4A,C,D hydrolyse cAMP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28379", "l": "ATP + N(6)-(D-fructosyl)-L-lysine => ADP + H(+) + N(6)-(6-phospho-D-fructosyl)-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47387", "l": "4-acetoxyphenol + H2O <=> acetate + H(+) + hydroquinone"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047302", "l": "UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34219", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O + NAD(+) = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.85", "l": "\"2-hydroxymuconate-6-semialdehyde dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602454", "l": "proMMP9 binds TIMP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047281", "l": "dioxotetrahydropyrimidine phosphoribosyltransferase activity"}, {"i": "RHEA:10232", "l": "5,6-dihydrouridine 5'-monophosphate + diphosphate = 5,6-dihydrouracil + 5-phospho-alpha-D-ribose 1-diphosphate"}, {"i": "EC:2.4.2.20", "l": "\"Dioxotetrahydropyrimidine phosphoribosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72130", "l": "Formation of an intermediate Spliceosomal C (Bact) complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174070", "l": "Association of Cdh1 with the APC/C (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48369", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose => beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814671", "l": "Fusion of late-endosome derived vesicles at the TGN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9692809", "l": "CDC42 binds effectors at the ER membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55583", "l": "ATP + H2O + L-glutamine <=> AMP + 2 H(+) + N(5)-phospho-L-glutamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156699", "l": "Inactivation of Wee1 kinase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14120", "l": "[(1->4)-alpha-D-galacturonosyl](n) + H2O <=> [(1->4)-alpha-D-galacturonosyl](n-1) + alpha-D-galacturonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51917", "l": "(2S)-2-amino-3-butenoate + H2O => 2-oxobutanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28475", "l": "D-glucarate(in) => D-glucarate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10410", "l": "3-oxopristanoyl-CoA + CoA => 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-170149", "l": "Translocation of active Cdc25C to the nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769370", "l": "WIF1 binds WNTs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68960", "l": "DNA polymerase epsilon binds at the origin (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0008029", "l": "pentraxin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674531", "l": "AAMP binds EGFR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169398", "l": "ISGylation of host protein filamin B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35489", "l": "2-hydroxy-2,3-dihydrogenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102987", "l": "palmitoleic acid delta 12 desaturase activity"}, {"i": "RHEA:45096", "l": "(9Z)-hexadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-hexadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}, {"i": "MetaCyc:RXN-9616"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730837", "l": "Recruitment of GRB2:SOS to p-10Y-NTAL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31839", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-3-dehydro-6-deoxy-alpha-D-glucose"}, {"i": "EC:5.3.2.4", "l": "\"TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53694", "l": "H(+) + prostaglandin E2 + sn-glycerol 3-phosphocholine => 2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706336", "l": "Active FLT3 binds to SYK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612493", "l": "EGR-dependent NAB2 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37414", "l": "aklavinone + NADP(+) <=> aklaviketone + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1222491", "l": "Lactoferrin scavenges iron ions (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47326", "l": "3-oxo-3-phenylpropanoate + L-alanine => (S)-3-amino-3-phenylpropanoate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624125", "l": "Formation of the BBSome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015431", "l": "ABC-type glutathione S-conjugate transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45025", "l": "cholesterol + H(+) + NADPH + O2 => cholesta-5,7-dien-3beta-ol + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16056", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosamine <=> H(+) + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64114", "l": "a fatty acid + L-phenylalanine => an N-acyl-L-phenylalanine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51817", "l": "ATP(in) + CoA(in) + dodecanoate(out) + H(+)(out) => AMP(in) + diphosphate(in) + dodecanoyl-CoA(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41527", "l": "5 H(+) + 5 malonyl-CoA <=> 5 CO2 + 5 CoA + H2O + naphthalene-1,3,6,8-tetrol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102165", "l": "(Z)-3-hexen-1-ol acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507875", "l": "Aquaporins passively transport urea into cells (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65083", "l": "asperaculane D + O2 + reduced [NADPH--hemoprotein reductase] <=> asperaculane E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61498", "l": "an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + GDP + H(+) => an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34756", "l": "H2O + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine => D-glucose + N-acyl-15-methylhexadecasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19921", "l": "D-ribitol 5-phosphate + NADP(+) = D-ribulose 5-phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140078", "l": "class I DNA-(apurinic or apyrimidinic site) endonuclease activity"}, {"i": "RHEA:66592", "l": "(DNA)-(deoxyribonucleoside 5'-phosphate)-(deoxyribose 5'-phosphate)-(deoxyribonucleoside 5'-phosphate) = (DNA)-3'-(deoxyribonucleoside 5'-phosphate)-(2,3-dehydro-2,3-deoxyribose 5'-phosphate) + H(+) + phospho-5'-(DNA)"}, {"i": "MetaCyc:4.2.99.18-RXN"}, {"i": "EC:4.2.99.18", "l": "\"DNA-(apurinic or apyrimidinic site) lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848751", "l": "PTK6 binds AKT1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26425", "l": "3'-phosphoadenylyl sulfate + thyroxine <=> adenosine 3',5'-bisphosphate + H(+) + thyroxine sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2467794", "l": "Resolution of sister chromatids (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14169", "l": "ATP + CoA + glutarate = ADP + glutaryl-CoA + phosphate"}, {"i": "EC:6.2.1.6", "l": "\"Glutarate--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610733", "l": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58086", "l": "(13Z)-docosenoate + glycerol + H(+) => 1-(13Z-docosenoyl)-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28690", "l": "(S)-dihydroorotate + ubiquinone-8 <=> orotate + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686587", "l": "ABL1 phosphorylates RAD52 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41320", "l": "1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 2-acetyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14695", "l": "dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP => dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53049", "l": "2-hydroxyestrone + UDP-alpha-D-glucuronate => 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804596", "l": "APAF1:CYCS binds APIP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047958", "l": "glycine:2-oxoglutarate aminotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58508", "l": "(3Z)-2-oxo-4-carboxy-3-hexenedioate + H2O = (2S)-2-hydroxy-4-oxobutane-1,2,4-tricarboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44533", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66245", "l": "ATP + H(+) + IC-asc-C9 => diphosphate + IC-asc-C9-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174124", "l": "Dephosphorylation of phospho-Cdh1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.12", "l": "\"Alpha-lytic endopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31136", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + diphosphate => 5-amino-4-imidazolecarboxyamide + 5-phospho-alpha-D-ribose 1-diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35984", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59505", "l": "cholesterol + glycyl-L-cysteinyl-[protein] + H(+) => [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9687625", "l": "ATP binds MLKL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023859", "l": "Estrogen-responsive TFF1 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72124", "l": "Formation of the Spliceosomal A Complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53124", "l": "all-trans-lycopene = delta-carotene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.20.14", "l": "\"Hapalindole-type alkaloid chlorinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015310", "l": "benomyl:proton antiporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140260", "l": "mitochondrial proton-transporting ATP synthase complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11722", "l": "ADP + 2 H(+) + N-carbamoylsarcosine + phosphate => ATP + 2 H2O + N-methylhydantoin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635859", "l": "GLI:SUFU dissociates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54980", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose = [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n+1)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015413", "l": "ABC-type nickel transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6796649", "l": "TP53 binds the CCNK gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14477", "l": "a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]"}, {"i": "EC:1.3.8.7", "l": "\"Medium-chain acyl-CoA dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0140522", "l": "fusogenic activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134946", "l": "DDX41 ubiquitination by TRIM21 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34871", "l": "methanol(out) = methanol(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37242", "l": "2',3'-cyclic UMP + H2O <=> H(+) + uridine 2'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53549", "l": "prostaglandin J2 => Delta(12)-prostaglandin J2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209193", "l": "Phosphorylated AP-1, Phospho JRA:Phospho KAY dissociates from CKA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55401", "l": "7-cyano-7-carbaguanosine(15) in tRNA + NH4(+) => archaeosine(15) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009558", "l": "IL34 dimer binds SDC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23071", "l": "6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA <=> 6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32411", "l": "(1R,2R,4S)-isodihydrocarveol + NAD(+) = (1R,4S)-isodihydrocarvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36488", "l": "agmatine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + N(1)-aminopropylagmatine + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-434836", "l": "Syk/Lck phosphorylate LAT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340226", "l": "CYGB dioxygenates NO (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450348", "l": "Activated human JNKs migrate to nucleoplasm (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019784", "l": "NEDD8-specific protease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61535", "l": "ent-kaur-16-ene + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> ent-kaur-16-en-19-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870465", "l": "RGGT binds the RAB-binding subunit (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56371", "l": "3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 <=> 3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53143", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1268022", "l": "TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158832", "l": "The acetyl group from acetyl-CoA is transferred to the NAT2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46242", "l": "2 [Fe(III)-cytochrome b5] + a (9Z,12E)-hexadecadienoyl-containing glycerolipid + 2 H2O => 2 [Fe(II)-cytochrome b5] + a (9Z)-hexadecenoyl-containing glycerolipid + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42660", "l": "NAD(+) + UDP-N-acetyl-alpha-D-glucosamine = H(+) + NADH + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose"}, {"i": "EC:1.1.1.374", "l": "\"UDP-N-acetylglucosamine 3-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13737", "l": "an n-alkanal + NADP(+) = an alk-2-enal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371422", "l": "ATP hydrolysis by HSP70 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45443", "l": "H2O + N-eicosanoyl-sn-glycero-3-phosphoethanolamine <=> H(+) + N-eicosanoyl ethanolamine + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17159", "l": "ADP + H(+) + N-phosphocreatine => ATP + creatine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045295", "l": "gamma-catenin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668735", "l": "RAC1:GTP binds NOX3 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43513", "l": "2-(dihydroxymethyl)-5-formylfuran + O2 => 2-carboxy-5-formylfuran + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36543", "l": "H2O + mycothiol S-conjugate = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate"}, {"i": "EC:3.5.1.115", "l": "\"Mycothiol S-conjugate amidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004996", "l": "thyroid-stimulating hormone receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23569", "l": "(2E)-decenoyl-[ACP] => (3Z)-decenoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357429", "l": "AXL autophosphorylates on Y772 and Y814 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990725", "l": "cord factor receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016966", "l": "nitric oxide reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029456", "l": "RAC1 and CDC42 activate PAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730842", "l": "PI3K associates with phosphorylated GAB2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51828", "l": "ATP(in) + CoA(in) + docosanoate(out) + H(+)(out) = AMP(in) + diphosphate(in) + docosanoyl-CoA(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15578", "l": "H2O + uridine => D-ribose + uracil"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8985943", "l": "p-Y701-STAT1 dimerizes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-452091", "l": "Phosphorylation of IL2RB Y338 enables SHC recruitment (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28041", "l": "[thioredoxin]-disulfide + dCDP + H2O <=> [thioredoxin]-dithiol + CDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30780", "l": "D-gluconate + FAD + H(+) => 2-dehydro-D-gluconate + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446634", "l": "IRAK4 is activated by autophosphorylation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24618", "l": "estrone + H(+) + NADPH => 17beta-estradiol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73800", "l": "SAICAR => AICAR + Fumarate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684140", "l": "ATM phosphorylates RBBP8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24993", "l": "L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60987", "l": "16-hydroxyhexadecanoate + NAD(+) <=> 16-oxohexadecanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0005024", "l": "transforming growth factor beta-activated receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983152", "l": "Transfer of ubiquitin from E1 to E2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63749", "l": "UDP-alpha-D-glucuronate + zolasartan => UDP + zolarsartan-2-N-beta-D-glucuronide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22145", "l": "cis-aconitate + H2O => D-threo-isocitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19430", "l": "[beta-adrenergic receptor] + ATP => [beta-adrenergic receptor]-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43267", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA <=> 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5681987", "l": "LC3 is cleaved by ATG4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52540", "l": "cytidine + phosphate = alpha-D-ribose 1-phosphate + cytosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58962", "l": "benzoate + H(+) + H2O2 => benzaldehyde + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15914", "l": "ATP + thiamine phosphate => ADP + thiamine diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0070548", "l": "L-glutamine aminotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33235", "l": "2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 = 3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+)"}, {"i": "EC:1.14.13.81", "l": "\"Magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10427", "l": "H2O + N-benzoylglycine <=> benzoate + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27744", "l": "2-deoxy-alpha-D-ribose 1-phosphate + adenine => 2'-deoxyadenosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683385", "l": "Formation of BRCA1-A complex at DNA DSBs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72663", "l": "De novo formation of eIF2:GTP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19508", "l": "indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose <=> (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5676229", "l": "WIPIs bind PI3P (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204824", "l": "Interaction of Tie2 and Ang4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666458", "l": "IgG:Leishmania surface:FCGR3A translocates from plasma membrane to the parasitophorous vacuole (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42296", "l": "a 1-acyl-sn-glycero-3-phosphate + a fatty acyl-[ACP] = a 1,2-diacyl-sn-glycero-3-phosphate + holo-[ACP]"}, {"i": "EC:2.3.1.n4", "l": "\"1-acyl-sn-glycerol-3-phosphate acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52284", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46608", "l": "ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21935", "l": "S-adenosyl-L-methionine <=> homoserine lactone + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021851", "l": "MECP2 binds CREB1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56937", "l": "17beta-hydroxy-androst-5-en-3-one => testosterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200406", "l": "CPT1A,B transfers PALM to CAR (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36751", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = beta-D-Gal-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}, {"i": "EC:2.4.1.304", "l": "\"UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol beta-1,4-galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56434", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16023", "l": "enol-oxaloacetate => oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981610", "l": "Neuroglobin binds oxygen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46592", "l": "alfacalcidol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcitriol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36595", "l": "hydrogen sulfide + NADP(+) = NADPH + sulfur"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35584", "l": "2-dehydro-3-deoxy-D-gluconate => D-glyceraldehyde + pyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038122", "l": "C-C motif chemokine 5 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58148", "l": "ethyl acetate + H2O = acetate + ethanol + H(+)"}, {"i": "EC:3.1.1.113", "l": "\"Ethyl acetate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018746", "l": "RHOQ binds effectors at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10387", "l": "cyclo-acetoacetyl-L-tryptophan + dimethylallyl diphosphate <=> beta-cyclopiazonate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65248", "l": "AH2 + 5 H(+) + 5 malonyl-CoA = 6-hydroxymellein + A + 5 CO2 + 5 CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63165", "l": "H2O + N-tricosanoyl-taurine => taurine + tricosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23502", "l": "3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60051", "l": "a 3beta-hydroxy-4,4-dimethylsteroid + 2 H(+) + 3 NADH + 3 O2 <=> a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 4 H2O + 3 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65510", "l": "H2O2 + NH4(+) + pre-mycofactocin => 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3965450", "l": "DAAM1 recruits PFN1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12175", "l": "alpha-D-glucosamine 6-phosphate + H2O <=> beta-D-fructose 6-phosphate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0000104", "l": "succinate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33643", "l": "(9Z)-tetradecenoate + ATP + CoA = (9Z)-tetradecenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18775", "l": "[Co(I) methylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M => [methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65334", "l": "chrodrimanin E + H2O + NADP(+) => H(+) + NADPH + O2 + verruculide A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66573", "l": "2-naphthol + 3'-phosphoadenylyl sulfate => 2-naphthyl sulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17381", "l": "(9Z,12Z)-octadecadienoate = (9Z,11E)-octadecadienoate"}, {"i": "EC:5.2.1.5", "l": "\"Linoleate isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33875", "l": "cholesteryl (9Z-octadecenoate) + H2O = (9Z)-octadecenoate + cholesterol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2197698", "l": "Src phosphorylate WASP,N-WASP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50170", "l": "N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48967", "l": "2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 <=> [thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52689", "l": "3-phenyllactate + NAD(+) => 3-phenylpyruvate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63760", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693761", "l": "FA2H hydroxylates CERA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-203700", "l": "eNOS translocation from Golgi to Caveolae (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65848", "l": "A + a 3-oxo-Delta(1)-steroid + H2O = a steroid 1,3-dione + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12342", "l": "H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu) => L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47880", "l": "dioctanoylglycerol + H2O = H(+) + octanoate + octanoylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.343", "l": "\"Phosphogluconate dehydrogenase (NAD(+)-dependent, decarboxylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9007539", "l": "CHEK1 phosphorylates E2F6 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48039", "l": "globoside Gb4Cer (d18:1(4E)) + H2O <=> globoside Gb3Cer (d18:1(4E)) + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602454", "l": "proMMP9 binds TIMP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59210", "l": "diphosphate + octadecanoyl-AMP => ATP + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59171", "l": "ATP + holo-[(hydroxy)phthioceranic acid synthase] + octadecanoate <=> AMP + diphosphate + octadecanoyl-[(hydroxy)phthioceranic acid synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176700", "l": "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71050", "l": "Trimerization of the FASL:FAS receptor complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57890", "l": "a quinol + 4 H(+)(out) + NAD(+) => a quinone + 5 H(+)(in) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24019", "l": "16-epivellosimine + acetyl-CoA <=> CoA + vinorine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74059", "l": "PDE6 hydrolyses cGMP to GMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35558", "l": "cyclo(L-leucyl-L-leucyl) + 4 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] + pulcherriminic acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65189", "l": "2-oxoglutarate + berkeleyone B + O2 => berkeleydione + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27575", "l": "(3R)-piperidine-3-carboxamide + H2O => (3R)-piperidine-3-carboxylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14815", "l": "D-2-aminohexano-6-lactam => L-2-aminohexano-6-lactam"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052901", "l": "spermine:oxygen oxidoreductase (spermidine-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51054", "l": "5alpha-androst-1-ene-3,17-dione + AH2 => 5alpha-androstan-3,17-dione + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27612", "l": "CO2 + H2 => formate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874080", "l": "SRC phosphorylates PTK2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20803", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38546", "l": "H(+) + malonyl-CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein] <=> (2-aminobenzoyl)acetyl-CoA + CO2 + L-cysteinyl-[PqsD protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848975", "l": "PTK6 phosphorylates KHDRBS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33323", "l": "a 1-acyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = a 1-acyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004028", "l": "3-chloroallyl aldehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8931981", "l": "RUNX1 binds ESR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645481", "l": "TIFA oligomerization (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21447", "l": "3-(2-hydroxyphenyl)propanoate + NAD(+) <=> H(+) + NADH + trans-2-coumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52602", "l": "CoA + H(+) + N-propanoyl-L-methioninate => L-methionine + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34576", "l": "2 H(+) + O2 + pentalenolactone F + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalenolactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28883", "l": "H(+)(in) + L-threonine(in) = H(+)(out) + L-threonine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43855", "l": "H(+) + malonyl-CoA + triacontanoyl-CoA <=> 3-oxo-dotriacontanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909724", "l": "Recruitment of IFNAR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56546", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N-hexadecanoyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202168", "l": "Phosphorylation of ZAP-70 by Lck (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55573", "l": "4-hydoxytryptamine 4-phosphate + S-adenosyl-L-methionine => 4-hydroxy-N-methyltryptamine 4-phosphate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34579", "l": "2 2-oxoglutarate + 2 O2 + pentalenolactone D = 2 CO2 + H2O + pentalenolactone F + 2 succinate"}, {"i": "EC:1.14.11.36", "l": "\"Pentalenolactone F synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20417", "l": "coelenterazine + O2 = CO2 + coelenteramide + hnu"}, {"i": "EC:1.13.12.13", "l": "\"Oplophorus-luciferin 2-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-182986", "l": "CBL-mediated ubiquitination of CIN85 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49033", "l": "(-)-4'-desmethyl-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] => 4'-demethylepipodophyllotoxin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2197698", "l": "Src phosphorylate WASP,N-WASP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64180", "l": "an N-(fatty acyl)-L-tryptophan + H2O = a fatty acid + L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32460", "l": "2 S-adenosyl-L-methionine + uroporphyrinogen III => H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40162", "l": "H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose <=> NAD(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58960", "l": "benzaldehyde + H2O + O2 = benzoate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.24"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791058", "l": "Expression of Cullin-7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20115", "l": "beta-D-glucose 6-phosphate => beta-D-glucose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5685230", "l": "CHEK1 phosphorylates RAD51 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57454", "l": "H(+) + N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine => L-glutaminyl-[protein] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30657", "l": "ADP + dUDP => ATP + dUMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65668", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontenoyl)-sphing-4-enine = a diacylglycerol + an N-(32-(9Z,12Z-octadecadienoyloxy)-dotriacontenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51039", "l": "2 2-iminio-3-(indol-3-yl)propanoate + H2O2 <=> 2 H2O + indole-3-pyruvate imine dimer"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110219", "l": "Cleavage of thymine by TDG glycosylase (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10078", "l": "D-galactose + D-glucose => H2O + lactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23878", "l": "H2O + xanthoaphin => protoaphin aglucone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18644", "l": "a menaquinone + H2 <=> a menaquinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10064", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + D-alanine + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine"}, {"i": "EC:2.1.2.7", "l": "\"D-alanine 2-hydroxymethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23244", "l": "propane-1,3-diamine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + norspermidine + S-methyl-5'-thioadenosine"}, {"i": "EC:2.5.1.23", "l": "\"Sym-norspermidine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32987", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a carboxylate + H(+) + sn-glycero-3-phospho-1D-myo-inositol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029471", "l": "Hydrolysis of PC to PA by PLD (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12732", "l": "lutein <=> (3R,3'S)-zeaxanthin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46733", "l": "(2R,6)-dimethylheptanoyl-CoA => (2S,6)-dimethylheptanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56087", "l": "[Rab1 protein]-O-phosphocholine-L-serine + H2O <=> [Rab1 protein]-L-serine + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31178", "l": "(2E)-2-methylpropenoyl-CoA + H2O <=> (S)-3-hydroxyisobutanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22781", "l": "(9Z,12Z)-octadecadienoate + O2 => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69068", "l": "RFC dissociates after sliding clamp formation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31237", "l": "(4R)-4-hydroxy-2-oxoglutarate + L-glutamate => (4S)-4-hydroxy-L-glutamate + 2-oxoglutarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449115", "l": "IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28541", "l": "ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A <=> ADP + H(+) + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37406", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66844", "l": "asperterpenoid A + O2 + reduced [NADPH--hemoprotein reductase] = asperterpenoid C + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15874", "l": "[(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose => [(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60767", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-cinerolone <=> cinerin II + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21116", "l": "D-maltose + phosphate = beta-D-glucose 1-phosphate + D-glucose"}, {"i": "EC:2.4.1.8", "l": "\"Maltose phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8870465", "l": "RGGT binds the RAB-binding subunit (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45558", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-dodecanoylethanolamine => H2O + N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32314", "l": "L-tyrosine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8985943", "l": "p-Y701-STAT1 dimerizes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45596", "l": "H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52443", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose <=> a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26312", "l": "1,4-dihydroxy-2-naphthoyl-CoA + H2O <=> 1,4-dihydroxy-2-naphthoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209536", "l": "IkB is ubiquitinated and degraded (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008684", "l": "TBK1 phosphorylation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.16", "l": "\"Spermine oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.16"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901024", "l": "MAN1B1 hydrolyses 1,2-linked mannose (a branch) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191786", "l": "snRNP complex assembly (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8939203", "l": "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64609", "l": "L-threonyl-[protein] + UTP => diphosphate + uridylyl-L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2106625", "l": "Duplex siRNA is loaded into Argonaute (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16356", "l": "2-oxoglutarate + taurine <=> L-glutamate + sulfoacetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31573", "l": "CO2 + H2O + NADP(+) + naphthalene-1,2-diol => 1-hydroxy-2-naphthoate + 2 H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51138", "l": "(10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32116", "l": "2-oxoglutarate + DIBOA beta-D-glucoside + O2 => CO2 + succinate + TRIBOA beta-D-glucoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62527", "l": "cytidine(839) in 12S rRNA + S-adenosyl-L-methionine <=> H(+) + N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14068", "l": "scyllo-inosose <=> 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45116", "l": "(4R)-ipsdienol + NADP(+) = H(+) + ipsdienone + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213241", "l": "Formation of nonameric complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62133", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dTTP => a 2'-deoxyribonucleoside 5'-diphosphate + dTDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56107", "l": "2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2 <=> 4,4'-diaponeurosporenal + 2 A + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38457", "l": "(9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23337", "l": "2 H(+) + H2O2 + 2 iodide => diiodine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41709", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphoethanolamine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65569", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421447", "l": "protoporphyrin IX + Fe++ => heme + 2 H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66988", "l": "4-methylpentanoate + ATP + CoA = 4-methylpentanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3244643", "l": "STING binds cyclic GMP-AMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3204311", "l": "AOX1 oxidises PXL to PDXate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791082", "l": "Expression of Calreticulin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950634", "l": "Expression of capping actin protein of muscle Z-line alpha subunit 1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65508", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + H2O + O2 = H2O2 + NH4(+) + pre-mycofactocin"}, {"i": "EC:1.4.3.26", "l": "\"Pre-mycofactocin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43383", "l": "H2O + N(omega)-phospho-L-arginyl-[protein] <=> L-arginyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.190"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016521", "l": "pituitary adenylate cyclase activating polypeptide activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46485", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate => alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322434", "l": "XIAP dissociates from ub-TLE (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "74.603620314006946", "identifiers": [{"i": "GO:0016899", "l": "oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor"}, {"i": "EC:1.1.3.-", "l": "\"With oxygen as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691004", "l": "XPC binds RAD23 and CETN2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16957", "l": "3',5'-cyclic GMP + H2O = GMP + H(+)"}, {"i": "EC:3.1.4.35", "l": "\"3',5'-cyclic-GMP phosphodiesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712088", "l": "ALK fusion proteins bind IRS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41352", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-171141", "l": "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798743", "l": "Exocytosis of secretory granule membrane proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58298", "l": "25-substituted-cholesteryl beta-D-glucoside + N-hexadecanoylsphing-4-enine => 25-substituted-cholesterol + beta-D-glucosyl-N-hexadecanoylsphing-4E-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29454", "l": "H2O + phosphonate <=> H2 + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928617", "l": "EPHB2 binds KALRN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19743", "l": "CoA + formate + H(+) => formyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655170", "l": "RCHY1 monoubiquitinates POLH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43440", "l": "hexadecanoate + sphinganine = H2O + N-hexadecanoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173631", "l": "Activation of C1s (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33636", "l": "ATP + CoA + docosanoate => AMP + diphosphate + docosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047893", "l": "flavonol 3-O-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51888", "l": "2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+) = 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH"}, {"i": "EC:1.1.1.404", "l": "\"Tetrachlorobenzoquinone reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009072", "l": "STAT3 phosphorylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008765", "l": "UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046480", "l": "galactolipid galactosyltransferase activity"}, {"i": "RHEA:15921", "l": "2 a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol = a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a 1,2-diacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693593", "l": "D-loop extension by DNA polymerases (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15058", "l": "(9Z)-octadecenoyl-[ACP] + H2O => (9Z)-octadecenoate + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034525", "l": "1-naphthaldehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60014", "l": "a tRNA with a 3' CCA end + diphosphate => a tRNA with a 3' CC end + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32459", "l": "2 S-adenosyl-L-methionine + uroporphyrinogen III = H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.107", "l": "\"Uroporphyrinogen-III C-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.47"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.3", "l": "\"Glucan 1,4-alpha-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66651", "l": "(2E,6E)-farnesyl diphosphate <=> african-3-ene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047532", "l": "2,5-dioxopiperazine hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3341277", "l": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28012", "l": "propanoate + succinyl-CoA => propanoyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0031690", "l": "adrenergic receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66891", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0016972", "l": "thiol oxidase activity"}, {"i": "MetaCyc:THIOL-OXIDASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32190", "l": "cholest-5-en-3-one <=> cholest-4-en-3-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1977959", "l": "ERBB4 forms heterodimers with EGFR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5218821", "l": "PDK1 phosphorylates PKC (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9688456", "l": "MLKL binds FLOT1, FLOT2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63091", "l": "a ribonucleotide in U6 snRNA + S-adenosyl-L-methionine <=> a 2'-O-methylribonucleotide in U6 snRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047915", "l": "ganglioside galactosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65414", "l": "dAMP(out) + NAD(+)(in) => dAMP(in) + NAD(+)(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070742", "l": "C2H2 zinc finger domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985293", "l": "NKX3-2 binds RUNX2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65914", "l": "4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-alanine => 3-hydroxy-L-kynurenine + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16579", "l": "P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate => ADP + ATP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28903", "l": "D-alanine(in) + H(+)(in) = D-alanine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40022", "l": "ent-copalyl diphosphate + H2O <=> (-)-ent-copalol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26436", "l": "H2O + L-tryptophan => indole + L-serine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008788", "l": "alpha,alpha-phosphotrehalase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11694", "l": "NADH + NADP(+) => NAD(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110446", "l": "Phospho-Chico: Activated DINR binds p60:Dp110 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-555065", "l": "Formation of clathrin coated vesicle (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39733", "l": "3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51383", "l": "(9Z)-octadecenoyl-CoA + dopamine <=> CoA + H(+) + N-(9Z-octadecanoyl)-dopamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052659", "l": "inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23468", "l": "2-aminobenzenesulfonate + 2 H(+) + NADH + O2 = 2,3-dihydroxybenzenesulfonate + NAD(+) + NH4(+)"}, {"i": "EC:1.14.12.14", "l": "\"2-aminobenzenesulfonate 2,3-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66452", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + NADP(+) = 1-(9Z)-octadecenoylglycerone 3-phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63470", "l": "ADP + all-trans-octaprenyl phosphate + H(+) => all-trans-octaprenol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43396", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204798", "l": "Interaction of Tie2 and p85 of PI3K (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-517705", "l": "p-S318,221-HuR binds mRNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428625", "l": "Vesicular inhibitory amino acid transport (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159826", "l": "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672170", "l": "SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614460", "l": "Dimerization of procollagen type VI (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876484", "l": "NPC2 transfers CHOL to NPC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13510", "l": "H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP => diphosphate + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141316", "l": "TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64454", "l": "2 H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-homocysteine => L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17455", "l": "ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate => 5-phospho-beta-D-ribosylamine + ATP + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936380", "l": "Interaction of PIN1 with p-IRF3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0043121", "l": "neurotrophin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58819", "l": "ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047409", "l": "alkenylglycerophosphoethanolamine hydrolase activity"}, {"i": "RHEA:16905", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39332", "l": "(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H(+) + NADPH => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683735", "l": "CHEK2 is recruited to DNA DSBs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27319", "l": "uracil(in) => uracil(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16388", "l": "4-hydroxybenzoate + 2 H(+) + NADPH + O2 <=> CO2 + H2O + hydroquinone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23898", "l": "3-deoxy-D-glycero-2,5-hexodiulosonate => 5-dehydro-4-deoxy-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63402", "l": "Fe(II)-heme a + H2O => Fe(II)-hydroxyheme i"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203977", "l": "SAR1 Activation And Membrane Binding (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42770", "l": "a 2-oxocarboxylate + H(+) + NADPH => a (2S)-2-hydroxycarboxylate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15462", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) => 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018725", "l": "trans-3,4-dihydrodiolphenanthrene sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39891", "l": "devancoaminyl-vancomycin + dTDP-beta-L-vancosamine = dTDP + H(+) + vancomycin"}, {"i": "EC:2.4.1.322", "l": "\"Devancosaminyl-vancomycin vancosaminetransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44563", "l": "4-hydroxybenzoate + all-trans-heptaprenyl diphosphate <=> 4-hydroxy-3-all-trans-heptaprenylbenzoate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990407", "l": "calcitonin gene-related peptide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44445", "l": "a 1,2-diacylglycerol + H2O => a fatty acid + a monoacylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46943", "l": "AMP + diphosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] <=> ATP + holo-[LYS2 peptidyl-carrier protein] + L-2-aminoadipate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036011", "l": "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (b branch) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1912369", "l": "NOTCH precursor cleaved to form mature NOTCH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65024", "l": "7alpha-hydroxy-3,12-dioxo-5beta-cholanate + NADP(+) = dehydrocholate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9653514", "l": "USP17L2 deubiquitinates RCE1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37825", "l": "2,4-dichlorophenol + CO2 + pyruvate + succinate => (R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421174", "l": "inosine + orthophosphate <=> hypoxanthine + D-ribose 1-phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417908", "l": "P2RY1 binds ADP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36997", "l": "3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + CO2 + CoA => (16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033896", "l": "ribonuclease IX activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191656", "l": "Closure of gap junction (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45826", "l": "CO2 + ethanolamine => H(+) + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32212", "l": "(Z)-5-oxohex-2-enedioate => (2E,4Z)-2-hydroxyhexa-2,4-dienedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30202", "l": "2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate <=> 2 ATP + benzoyl-CoA + 2 H2O + reduced 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682258", "l": "nsp14 binds nsp12 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876731", "l": "CHEST translocates from ER membrane to lipid particle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40132", "l": "(9Z)-hexadecenoyl-CoA + H2O => (9Z)-hexadecenoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42478", "l": "2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate => 2,2',3-trihydroxydiphenyl ether + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014294", "l": "RAC2 binds effectors at the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58216", "l": "A + dihydroserpentine = AH2 + serpentine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5226999", "l": "ADD1:ADD3 binds DMTN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632646", "l": "SMURF1/2 bind PTCH1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57615", "l": "20 H(+) + holo-[compactin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH <=> 9 CO2 + 9 CoA + dihydro-ML-236C-[compactin nonaketide synthase] + 6 H2O + 11 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433936", "l": "Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TICAM1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63037", "l": "H2O + octadecanamide => NH4(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41778", "l": "CMP + ganglioside GM2 (d18:1(4E)/18:0) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)/18:0)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26516", "l": "6-oxohexanoate + H(+) => cyclohexan-1,2-dione + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40516", "l": "6-deoxy-6-sulfo-D-fructose 1-phosphate => 3-sulfolactaldehyde + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9680443", "l": "ROCK1,2 bind ROCKi (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453183", "l": "p-Y348-SYK dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0030371", "l": "translation repressor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17749", "l": "A + H2O + quinoline = AH2 + quinolin-2(1H)-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45323", "l": "H2O + N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine <=> H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25006", "l": "L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102665", "l": "indole-3-acetyl-glutamate synthetase activity"}, {"i": "MetaCyc:RXN-2947"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42261", "l": "H(+) + heptanoyl-CoA + malonyl-[ACP] => 3-oxononanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11876", "l": "NAD(+) + prostaglandin E2 = 15-oxoprostaglandin E2 + H(+) + NADH"}, {"i": "EC:1.1.1.141", "l": "\"15-hydroxyprostaglandin dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23741", "l": "4-hydroxyphenylacetonitrile + H(+) + NADPH + O2 => 4-hydroxymandelonitrile + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791016", "l": "SFTPB binds itself (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051268", "l": "alpha-keto amide reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26103", "l": "cis-homoaconitate + H2O => (2R)-homocitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848110", "l": "SOCS3 binds activated PTK6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977605", "l": "Factor H displaces Bb (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54942", "l": "3-oxo-(5Z)-dodecenoyl-[ACP] + CO2 + holo-[ACP] => (3Z)-decenoyl-[ACP] + H(+) + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604731", "l": "Autocatalytic activation of MMP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43079", "l": "erythrodiol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oleanolic aldehyde + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66530", "l": "diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] => ATP + O-(5'-adenylyl)-L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59449", "l": "dodecan-1-ol + NADP(+) => dodecanal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3240957", "l": "Formation of PRC2-EZH2 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51698", "l": "H(+) + S-adenosyl-L-homocysteine + xanthohumol => desmethylxanthohumol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0046995", "l": "oxidoreductase activity, acting on hydrogen as donor, with other known acceptors"}, {"i": "EC:1.12.98.-", "l": "\"With other, known, acceptors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58959", "l": "a ribonucleotide in RNA + S-adenosyl-L-methionine <=> a 2'-O-methylribonucleotide in RNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3204318", "l": "cob(II)alamin binds to MTRR:MTR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47743", "l": "1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate <=> CO2 + demethylphylloquinone + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68849", "l": "Mcm2-7 associates with the Cdt1:CDC6:ORC:origin complex, forming the pre-replicative complex (preRC) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37911", "l": "(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199046", "l": "Ligands bind L-selectin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25928", "l": "3-methylquinoline + A + H2O = 3-methylquinolin-2(1H)-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49058", "l": "asperlicin E + H2O + NADP(+) => asperlicin C + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58574", "l": "H2O2 + precondylocarpine acetate => O-acetyl-15alpha-stemmadenine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72619", "l": "eIF2:GTP is hydrolyzed, eIFs are released  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985943", "l": "p-Y701-STAT1 dimerizes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38452", "l": "hydrogen sulfide + NADP(+) + n sulfur => NADPH + (n+1) sulfur"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51761", "l": "a 2-acyl-4,6-diprenylphloroglucinol + dimethylallyl diphosphate => a 2-acyl-4,6,6-triprenylphloroglucinol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448591", "l": "Interleukin-32 binds proteinase-3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879222", "l": "MDP:NLRP1 binds ATP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60047", "l": "beta-D-Gal-(1<->1')-Cer + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61539", "l": "ent-kaur-16-ene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> ent-kaur-16-en-19-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37966", "l": "galactitol + NAD(+) <=> D-galactose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15802", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19091", "l": "H(+) + precorrin-1 + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uroporphyrinogen III"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28132", "l": "baicalein + D-glucuronate + H(+) => baicalin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64750", "l": "2-methyl-3-sulfanylbutan-1-ol + NH4(+) + pyruvate => H2O + S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17119", "l": "ADP + H(+) + N(5)-methyl-L-glutamine + phosphate => ATP + L-glutamate + methylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12884", "l": "ADP-alpha-D-glucose + sn-glycerol 3-phosphate <=> 2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022942", "l": "GAD2 gene expression is stimulated by MECP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45949", "l": "acetyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64889", "l": "ATP + holo-[ACP] + tetradecanoate => AMP + diphosphate + tetradecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018812", "l": "3-hydroxyacyl-CoA dehydratase activity"}, {"i": "REACT:R-HSA-8957389", "l": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11498", "l": "3-(uracil-1-yl)-L-alanine + acetate + H(+) => O-acetyl-L-serine + uracil"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48916", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b = CMP + ganglioside GD1c + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35379", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA = (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375151", "l": "Interaction of NCAM1 with collagens (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44092", "l": "ATP + CoA + nonadecanoate = AMP + diphosphate + nonadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47781", "l": "a cytidine in 25S rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in 25S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1640164", "l": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43038", "l": "2-aminoprop-2-enoate + H(+) + hydrogen sulfide => L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0045181", "l": "glutamate synthase activity, NAD(P)H as acceptor"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.32", "l": "\"Maleylacetate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046917", "l": "triphosphoribosyl-dephospho-CoA synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32582", "l": "(2E)-geranyl diphosphate <=> (1R,5R)-beta-pinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11299", "l": "2,5-dioxopentanoate + H2O + NADP(+) <=> 2-oxoglutarate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018782", "l": "cis-chloroacrylic acid dehalogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20780", "l": "ATP + GMP = ADP + GDP"}, {"i": "EC:2.7.4.8", "l": "\"Guanylate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50781", "l": "NADP(+) + octanal => (2E)-octenal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624125", "l": "Formation of the BBSome (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32397", "l": "(1S,4S)-dihydrocarvone + H(+) + NADH => (1S,2S,4S)-dihydrocarveol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0008106", "l": "alcohol dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696997", "l": "USP24 deubiquitinates DDB2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45668", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37748", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-octadecyl-sn-glycero-3-phosphocholine => 1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39806", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+) <=> (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209109", "l": "E2F1/E2F2/E2F3 and SP1 stimulate transcription of p14ARF mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222755", "l": "Peroxynitrite is reduced to nitrite by Tpx (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41509", "l": "L-ornithine + NADPH + O2 => H2O + N(5)-hydroxy-L-ornithine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10579", "l": "CTP + H(+) + N-methylethanolamine phosphate <=> CDP-N-methylethanolamine + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373047", "l": "malate + NAD+ <=> oxaloacetate + NADH + H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686335", "l": "CSF2RA:CSF2RB binds SFTPs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444691", "l": "Prokineticin receptors bind prokineticin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60205", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31229", "l": "di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP => di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11306", "l": "glyoxylate + urea => (S)-ureidoglycolate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46785", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(9Z,12Z,15Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32531", "l": "4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate = alpha-D-mannose 1-phosphate + D-glucose"}, {"i": "EC:2.4.1.281", "l": "\"4-O-beta-D-mannosyl-D-glucose phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047438", "l": "2-dehydro-3-deoxy-L-pentonate aldolase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102014", "l": "beta-D-galactose-importing ATPase activity"}, {"i": "RHEA:30011", "l": "ATP + beta-D-galactose(out) + H2O = ADP + beta-D-galactose(in) + H(+) + phosphate"}, {"i": "MetaCyc:ABC-18-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350186", "l": "CUBN binds GC:25(OH)D (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030544", "l": "Hsp70 protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362437", "l": "C-terminal Hh fragments are bound by lectins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41093", "l": "1-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine => a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209792", "l": "N-acetylation of serotonin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47892", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55665", "l": "2 AH2 + echinenone + 2 O2 => 2 A + canthaxanthin + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31976", "l": "H(+) + NADPH + O2 + taxusin => 7beta-hydroxytaxusin + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939203", "l": "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60962", "l": "(9Z)-18-hydroxyoctadec-9-enoate 18-O-beta-D-glucoside + H(+) + UDP => 18-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166726", "l": "Activation of MASPs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54480", "l": "1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23073", "l": "H(+) + oxaloacetate + phosphate => CO2 + H2O + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48944", "l": "ADP + bacteriochlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate = 3-acetyl-3-devinylchlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28953", "l": "H(+)(out) + L-arabinose(out) => H(+)(in) + L-arabinose(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20445", "l": "L-arogenate + oxaloacetate = L-aspartate + prephenate"}, {"i": "EC:2.6.1.78", "l": "\"Aspartate--prephenate aminotransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080073", "l": "spermidine:coumaroyl CoA N-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904855", "l": "proteasome regulatory particle binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57237", "l": "GMP + methylglyoxal => N(2)-(1-hydroxy-2-oxopropyl)-GMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168894", "l": "p-STAT5A/B dissociates from the Growth Hormone receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28755", "l": "a ubiquinone + sn-glycerol 3-phosphate = a ubiquinol + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64878", "l": "H(+) + phosphate + UMP => H2O + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61303", "l": "5-deoxy-D-ribulose 1-phosphate <=> acetaldehyde + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617209", "l": "CEBPB gene transcription is enhanced by phospho-CREB1 and phospho-STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42614", "l": "a plastoquinol + n H(+)(out) + NADP(+) => a plastoquinone + (n+1) H(+)(in) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41847", "l": "(3R)-hydroxyoctanoyl-[ACP] <=> (2E)-octenoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35148", "l": "(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(in) => (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56610", "l": "L-serine + tetrahydrosulfopterin => 5,10-methylenetetrahydrosulfopterin + glycine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64438", "l": "glycylglycyl-L-isoleucine(in) + H(+)(in) => glycylglycyl-L-isoleucine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204798", "l": "Interaction of Tie2 and p85 of PI3K (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38139", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46965", "l": "lactate + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047634", "l": "agmatine N4-coumaroyltransferase activity"}, {"i": "MetaCyc:AGMATINE-N4-COUMAROYLTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50120", "l": "taurine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44888", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-sn-glycero-3-phosphate + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21144", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-Glu)(n)"}, {"i": "EC:1.5.98.2", "l": "\"5,10-methylenetetrahydromethanopterin reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865454", "l": "CBFB binds RUNX3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57813", "l": "1-chloro-2-nitrobenzene + NADH + O2 => 3-chlorocatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55326", "l": "11-cis-retinyl hexadecanoate + CoA => 11-cis-retinol + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10969", "l": "a carboxylate + CoA + GTP => an acyl-CoA + GDP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17618", "l": "leukotriene C4 => glutathione + leukotriene A4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446322", "l": "PARVA associates with Paxillin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70692", "l": "ornithine => putrescine + CO2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44798", "l": "H(+) + menaquinol-13 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-13 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37440", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate => a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.5.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849435", "l": "PTPN1 dephosphorylates PTK6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042950", "l": "salicin transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19306", "l": "3-hydroxybenzoyl-CoA + 2 H(+) + 3 malonyl-CoA => 2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69891", "l": "Phosphorylation and activation of CHEK2 by ATM (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975122", "l": "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53712", "l": "2 Fe(III)-heme b = beta-hematin"}, {"i": "EC:4.99.1.8", "l": "\"Heme ligase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018776", "l": "trans-chloroacrylic acid dehalogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730902", "l": "Oligomerization of p-CARMA1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432129", "l": "FGR binds and phosphorylates LRP8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10632", "l": "D-mannonate + NAD(+) = D-mannuronate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395764", "l": "atREs binds to nascent CM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51228", "l": "17alpha-ethynylestradiol + 3'-phosphoadenylyl sulfate = 17alpha-ethynylestradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55366", "l": "all-trans-nonaprenyl diphosphate + 6 diphosphate => (2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9690493", "l": "RHOB binds effectors on endosomes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5695980", "l": "ACAD10 dehydrogenates S-2MPDA-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55004", "l": "1-hydroxylimonen-2-one + NADPH + O2 = 3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5252133", "l": "ATP6AP1 binds V-ATPase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19334", "l": "H(+) + oxalyl-CoA => CO2 + formyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58705", "l": "rifampicin hemiaminal => rifampicin ortho-naphthoquinone carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45602", "l": "5-dehydro-4-deoxy-D-glucarate + H(+) => D-galactaro-1,4-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38298", "l": "(R)-2-hydroxyglutarate + A <=> 2-oxoglutarate + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44195", "l": "2-methylhexadecanoate + ATP + CoA <=> 2-methylhexadecanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782943", "l": "UV-DDB ubiquitinates XPC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24209", "l": "1,5-anhydro-D-mannitol + NADP(+) => 1,5-anhydro-D-fructose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684248", "l": "SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21129", "l": "5alpha-cholesta-8,24-dien-3beta-ol + S-adenosyl-L-methionine => 24-methylene-5alpha-cholest-8-en-3beta-ol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.176"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39927", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664664", "l": "PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937037", "l": "RUNX1 and GATA1 bind the promoter of the MIR27A gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.76", "l": "\"L-iduronidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66919", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 9-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3204303", "l": "MRE11 binds cytosolic DNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672973", "l": "MAP2Ks phosphorylate MAPKs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57078", "l": "3-phosphoglycerate + glycolate + H(+) => 3-oxoisoapionate 4-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40066", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O <=> 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50952", "l": "7-chloro-L-tryptophan + AH2 + O2 = A + CO2 + 2 H2O + monodechloroaminopyrrolnitrin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9688459", "l": "RIPK3 binds HSP90:CDC37 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399939", "l": "Autophosphorylation of PAK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010474", "l": "glucose-1-phosphate guanylyltransferase (GDP) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47186", "l": "2 [Fe(III)-cytochrome b5] + cholesta-5,7,24-trien-3beta-ol + 2 H2O => 5alpha-cholesta-7,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24396", "l": "scytalone = 1,3,8-trihydroxynaphthalene + H2O"}, {"i": "EC:4.2.1.94", "l": "\"Scytalone dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10337", "l": "citrate => D-threo-isocitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5627775", "l": "Autophosphorylation of PAK1,2,3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855111", "l": "VLDLR binds PCSK9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8863472", "l": "DAB2 binds LRP2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201790", "l": "DARPP-32 is dephosphorylated on Thr75 by PP2A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5251942", "l": "Hikeshi binds HSP70s:ATP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983374", "l": "p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102953", "l": "hypoglycin A gamma-glutamyl transpeptidase activity"}, {"i": "MetaCyc:RXN-9157"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24778", "l": "C-13(2)-carboxypyropheophorbide a + methanol => H2O + pheophorbide a"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20894", "l": "butanoyl phosphate + CoA => butanoyl-CoA + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "62.02868707118116", "identifiers": [{"i": "GO:0015267", "l": "channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61334", "l": "ADP + H(+) + indoxyl sulfate(out) + phosphate => ATP + H2O + indoxyl sulfate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69173", "l": "Joining of adjacent Okazaki fragments (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43469", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => (8Z,10E,14Z)-12-hydroperoxyeicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19408", "l": "acetyl-CoA + citrate <=> (3S)-citryl-CoA + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.5", "l": "\"Bacterial ABC-type protein transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14062", "l": "H2O + N-(carboxymethyl)-D-alanine + NAD(+) => glycine + H(+) + NADH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14719", "l": "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate => D-erythrose 4-phosphate + H2O + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050510", "l": "N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937177", "l": "AHR:TCDD binds ARNT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52308", "l": "2-hydroxyglutarate + NADP(+) = 2-oxoglutarate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18924", "l": "5alpha-cholest-7-en-3beta-ol + H(+) + NADH + O2 <=> cholesta-5,7-dien-3beta-ol + 2 H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65967", "l": "ATP + H2O + taurocholate(out) <=> ADP + H(+) + phosphate + taurocholate(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004794", "l": "L-threonine ammonia-lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806974", "l": "MET dimers autophosphorylate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26534", "l": "3-hydroxypropanoate + ATP + CoA = 3-hydroxypropanoyl-CoA + AMP + diphosphate"}, {"i": "EC:6.2.1.36", "l": "\"3-hydroxypropionyl-CoA synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61981", "l": "H(+) + NADPH + ubiquinone-10 => NADP(+) + ubiquinol-10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58933", "l": "4 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 8 H(+) + malonyl-CoA + 4 NADPH => 5 CO2 + 6 CoA + demethylluteothin + 3 H2O + 4 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63369", "l": "ATP + H2O + spermine(out) => ADP + H(+) + phosphate + spermine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22800", "l": "cycloeucalenol = obtusifoliol"}, {"i": "EC:5.5.1.9", "l": "\"Cycloeucalenol cycloisomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54438", "l": "a (4S)-2,3-dehydroflavan-3,4-diol + CO2 + H(+) + H2O + succinate => 2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44952", "l": "(2E)-octenoyl-CoA + H(+) + NADPH = NADP(+) + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010296", "l": "prenylcysteine methylesterase activity"}, {"i": "RHEA:48520", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + H2O = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + H(+) + methanol"}, {"i": "MetaCyc:RXN-8409"}, {"i": "EC:3.1.1.n2", "l": "\"Protein-S-isoprenylcysteine alpha-carbonyl methylesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609689", "l": "HCMV Binds to the Host Cell via heparan sulfate proteoglycans (HSPG) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247840", "l": "WLS binds WNT ligands in the Golgi (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.25", "l": "\"(d)CMP kinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103063", "l": "trans-keto-C61-meroacyl-AMP ligase activity"}, {"i": "MetaCyc:RXN1G-4143"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008420", "l": "RNA polymerase II CTD heptapeptide repeat phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27356", "l": "4'-demethylrebeccamycin + S-adenosyl-L-methionine <=> H(+) + rebeccamycin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34957", "l": "5-(methylsulfanyl)-D-ribose(out) => 5-(methylsulfanyl)-D-ribose(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47144", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3814820", "l": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0030523", "l": "dihydrolipoamide S-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909726", "l": "Phosphorylation of STAT1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-179417", "l": "Multiubiquitination of Nek2A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1006169", "l": "Factor H binds host cell surface markers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391157", "l": "p-4Y-SIRPA:CD47 binds SKAP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54320", "l": "2 [Fe(II)-cytochrome b5] + a Delta(7)-sterol + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a Delta(5),Delta(7)-sterol + 2 H2O"}, {"i": "EC:1.14.19.20", "l": "\"Delta(7)-sterol 5(6)-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451347", "l": "Activation of JNK by DSCAM (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62640", "l": "[mycoredoxin]-L-dithiol + a hydroperoxide = [mycoredoxin]-L-disulfide + an alcohol + H2O"}, {"i": "EC:1.11.1.29", "l": "\"Mycoredoxin-dependent peroxiredoxin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391913", "l": "FPR2 binds FPR2 ligands (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16395", "l": "H(+) + juvenile hormone II carboxylate + methanol => H2O + juvenile hormone II"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65169", "l": "AH2 + O2 + preaustinoid A => A + H2O + preaustinoid A1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35641", "l": "glyoxylate + pyruvate => (4S)-4-hydroxy-2-oxoglutarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62436", "l": "L-lyxonate = 2-dehydro-3-deoxy-L-arabinonate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032140", "l": "single adenine insertion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809663", "l": "Formation of hair keratin fibres (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.20", "l": "\"S-sulfosulfanyl-L-cysteine sulfohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59069", "l": "demethyldeoxyspectinabilin + S-adenosyl-L-methionine => deoxyspectinabilin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32009", "l": "diphosphate + isopimara-8(14),15-diene => 9alpha-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66941", "l": "acetyl-CoA + 22 H(+) + 11 malonyl-CoA + 12 NADPH + S-adenosyl-L-methionine => 12 CO2 + 12 CoA + 8 H2O + 12 NADP(+) + S-adenosyl-L-homocysteine + soppiline B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-215526", "l": "CYP4F3 20-hydroxylates LTB4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33768", "l": "a 3-hydroxy-fatty acyl-CoA => a (2E)-enoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20005", "l": "an alpha-D-glucuronoside + H2O = an alcohol + D-glucuronate"}, {"i": "EC:3.2.1.139", "l": "\"Alpha-glucuronidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55526", "l": "3,4-dihydroxyphenylacetaldehyde + CO2 + H2O2 + NH4(+) => H(+) + H2O + L-dopa + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034807", "l": "4,5-dihydroxybenzo(a)pyrene methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15262", "l": "5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] => 5beta-cholestane-3alpha,7alpha,12alpha-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132094", "l": "C8 binds to C5b:C6:C7 complement complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45292", "l": "2-glyceryl-prostaglandin G2 + AH2 = 2-glyceryl-prostaglandin H2 + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2514865", "l": "cGMP dissociates from CNG channels (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57360", "l": "H2O + NADH = (6R)-NADHX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37378", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine <=> 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18084", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + pentalenene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47937", "l": "4-hydroxybenzaldehyde + H2O + NADP(+) => 4-hydroxybenzoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13925", "l": "(3R)-hydroxytetradecanoyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = holo-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine"}, {"i": "EC:2.3.1.129", "l": "\"Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24177", "l": "[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419145", "l": "5-phosphoribosylglycinamide (GAR) + 10-formyl-tetrahydrofolate => 5'-phosphoribosylformylglycinamide (FGAR) + tetrahydrofolate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22938", "l": "acetate + D-glucosamine 6-phosphate => H2O + N-acetyl-D-glucosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202248", "l": "Phosphorylation of PLC-gamma1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48784", "l": "D-erythrulose 4-phosphate = D-erythrose 4-phosphate"}, {"i": "EC:5.3.1.34", "l": "\"D-erythrulose 4-phosphate isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018814", "l": "RHOT1 hydrolyzes GTP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878054", "l": "HIPK2 phosphorylates RUNX1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047474", "l": "long-chain fatty acid luciferin component ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28223", "l": "3-dehydro-L-gulonate + ATP => 3-dehydro-L-gulonate 6-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37452", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + eicosanoyl-CoA => 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19883", "l": "diphosphate + H(+) + N(epsilon)-GMP-L-lysyl-[protein] => GTP + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61895", "l": "a (2E,4Z)-dienoyl-CoA + H(+) + NADPH <=> a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52347", "l": "(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate <=> (24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9604328", "l": "AKT1 phosphorylates NOTCH4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10587", "l": "4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH <=> 3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-996755", "l": "ZFPM proteins bind GATA proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432909", "l": "Interaction of Plectin with Integrin beta 4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36503", "l": "(9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24175", "l": "A + a 3-oxo-5beta-steroid <=> a 3-oxo-Delta(4)-steroid + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50717", "l": "dimethyl sulfone + FMNH2 + O2 => FMN + formaldehyde + 2 H(+) + H2O + methanesulfinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008976", "l": "polyphosphate kinase activity"}, {"i": "RHEA:19573", "l": "[phosphate](n) + ATP = [phosphate](n+1) + ADP"}, {"i": "EC:2.7.4.1", "l": "\"Polyphosphate kinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "80.155824608458104", "identifiers": [{"i": "GO:0016848", "l": "carbon-halide lyase activity"}, {"i": "EC:4.5.-.-", "l": "\"Carbon-halide lyases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24775", "l": "7(1)-hydroxychlorophyllide a + NADP(+) <=> chlorophyllide b + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1169192", "l": "PTP1B dephosphorylates GHR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58425", "l": "(E)-hex-2-en-1-ol + NADP(+) => (E)-hex--2-enal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27448", "l": "NADP(+) + xylitol <=> D-xylose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24436", "l": "H2 + methanophenazine = dihydromethanophenazine"}, {"i": "EC:1.12.98.3", "l": "\"Methanosarcina-phenazine hydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55162", "l": "coenzyme M-coenzyme B heterodisulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => coenzyme B + coenzyme M + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373705", "l": "Caspase cleavage of DCC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050588", "l": "apo-beta-carotenoid-14',13'-dioxygenase activity"}, {"i": "KEGG.REACTION:R08889"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57013", "l": "a menaquinone + H2O + sulfite => a menaquinol + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16705", "l": "17alpha-estradiol + NADP(+) = estrone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.124"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374683", "l": "Interaction of L1 with Neurocan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53781", "l": "beta-muricholate + lithocholoyl-CoA => beta-muricholoyl-CoA + lithocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421833", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004511", "l": "tyrosine 3-monooxygenase activity"}, {"i": "RHEA:18201", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa"}, {"i": "EC:1.14.16.2", "l": "\"Tyrosine 3-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10448", "l": "2-oxoglutarate + a flavanone + O2 = a flavone + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187575", "l": "Ubiquitination of phospho-p27/p21 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985343", "l": "RUNX2 binds SOX9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83656", "l": "TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004708", "l": "MAP kinase kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13524", "l": "(R)-lactate + 2 [Fe(III)cytochrome c] <=> 2 [Fe(II)cytochrome c] + 2 H(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31885", "l": "delta-amyrin => (S)-2,3-epoxysqualene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-165195", "l": "GTP loading by Rheb (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59042", "l": "4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52897", "l": "2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin => 2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35608", "l": "acetoin + NADP(+) => diacetyl + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32027", "l": "(2E,6E)-farnesyl diphosphate = (-)-alpha-cuprenene + diphosphate"}, {"i": "EC:4.2.3.95", "l": "\"(-)-alpha-cuprenene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48372", "l": "1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = a fatty acid + acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203700", "l": "eNOS translocation from Golgi to Caveolae (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008771", "l": "[citrate (pro-3S)-lyase] ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392202", "l": "Dissociation of the P2Y purinoceptor 12:Gi complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51156", "l": "ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Gln)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36010", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033836", "l": "flavonol 7-O-beta-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419645", "l": "Dimerization of LIMK1 by Hsp90 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47589", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1c (d18:1(4E)) => CMP + ganglioside GQ1c (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047904", "l": "fructose 5-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102471", "l": "2-hydroxynaringenin-6C-glucoside dehydratase activity"}, {"i": "MetaCyc:RXN-14076"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50875", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + O2 <=> (5,6,15R)-trihydroxy-(7E,9E,11Z,13E,17Z)-eicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52939", "l": "3-oxobutanoyl-[ACP] + acetyl-[ACP] + H2O <=> (3S)-hydroxy-3-methylglutaryl-[ACP] + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65958", "l": "ADP + estrone 3-sulfate(in) + H(+) + phosphate => ATP + estrone 3-sulfate(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60570", "l": "N-acetyl-D-tryptophan => N-acetyl-L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466710", "l": "Defective LRAT does not esterify RBP1:atROL and FACYLs to atREs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0032453", "l": "histone H3-methyl-lysine-4 demethylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39903", "l": "isoxazolin-5-one + O-acetyl-L-serine = 3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate + H(+)"}, {"i": "EC:2.5.1.119", "l": "\"Beta-(isoxazolin-5-on-4-yl)-L-alanine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.137"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47459", "l": "(3S)-hydroxy-(5Z-tetradecenoyl)-CoA + NAD(+) <=> 3-oxo-(5Z-tetradecenoyl)-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12599", "l": "CoA + H(+) + N-acetylphosphinothricin => acetyl-CoA + phosphinothricin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424476", "l": "Activation of RAC1 by VAV2/3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18129", "l": "2-oxoaldehyde + H2O + NADP(+) = a 2-oxocarboxylate + 2 H(+) + NADPH"}, {"i": "EC:1.2.1.49", "l": "\"2-oxoaldehyde dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046428", "l": "1,4-dihydroxy-2-naphthoate octaprenyltransferase activity"}, {"i": "RHEA:30099", "l": "1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H(+) = 2-demethylmenaquinol-8 + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31978", "l": "H(+) + NADPH + O2 + taxusin <=> 7beta-hydroxytaxusin + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444523", "l": "CXCR5 binds CXCL13 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033433", "l": "AUU codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-265456", "l": "NPC1L1 binds ezetimibe (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35294", "l": "11-methyldodecanoyl-CoA + H(+) + malonyl-CoA <=> 3-oxoisopentadecanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53709", "l": "(2E)-decenoyl-CoA + NADP(+) => (2E,4Z)-decadienoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10084", "l": "3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate + 2 H(+)"}, {"i": "EC:1.13.11.3", "l": "\"Protocatechuate 3,4-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48600", "l": "[protein-PII]-uridylyl-L-tyrosine + H2O = [protein-PII]-L-tyrosine + H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.32", "l": "\"Endo-1,3-beta-xylanase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47570", "l": "ganglioside GD1b (d18:1(4E)) + H(+) + UDP => ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60757", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-cinerolone => cinerin I + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032523", "l": "silicon efflux transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55774", "l": "a jasmonyl-L-amino acid + AMP + diphosphate + H(+) => a jasmonate + an L-alpha-amino acid + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26335", "l": "2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin => 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16940", "l": "1-O-alkyl-sn-glycerol + ATP <=> 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9647977", "l": "ICMT methylates S-Farn RAS proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592250", "l": "NRF1, PPRC1:HCFC1:NRF2 bind the TFB1M promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36741", "l": "CoA + H(+) + N-tetracosanoyl-heptadecasphing-4-enine => heptadecasphing-4-enine + tetracosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618584", "l": "CEBPB and phospho-STAT3 bind the promoter of the MYC gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034910", "l": "6-hydroxy-3-succinoylpyridine hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23649", "l": "dTDP-6-deoxy-beta-L-talose + NADP(+) => dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937728", "l": "SRC phosphorylates RUNX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29782", "l": "ATP + H2O + L-methionine(out) <=> ADP + H(+) + L-methionine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874079", "l": "PTK2 binds activated MET (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61406", "l": "ADP + H(+) + N-(3-O-phospho-D-ribulosyl)-cadaverine => ATP + N-(D-ribulosyl)-cadaverine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34170", "l": "2,6-dihydroxypseudooxynicotine + H2O <=> 2,6-dihydroxypyridine + 4-(methylamino)butanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784204", "l": "JAKs bind OSMR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047125", "l": "delta1-piperideine-2-carboxylate reductase activity"}, {"i": "MetaCyc:RXN-8166"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17300", "l": "2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33565", "l": "(4R)-hydroxysphinganine 1-phosphate + ADP + H(+) => (4R)-hydroxysphinganine + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848873", "l": "PTK6 phosphorylates ARAP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928578", "l": "EPH receptors autophosphorylate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061898", "l": "all-trans retinoic acid 3,4-desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63176", "l": "(2S)-ibuprofenoyl-CoA = (2R)-ibuprofenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29157", "l": "2 H2O(out) + NH4(+)(out) + 3 ubiquinone-8(in) => 2 H(+)(out) + nitrite(out) + 3 ubiquinol-8(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44536", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982645", "l": "GRKs bind ADRB2:Catecholamine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620788", "l": "FOXO1,FOXO3,FOXO4 binds RBL2 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062047", "l": "pipecolic acid N-hydroxylase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16937", "l": "1-O-alkyl-sn-glycerol + ATP = 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+)"}, {"i": "EC:2.7.1.93", "l": "\"Alkylglycerol kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390663", "l": "ADRA2A,B,C bind ADR,NAd (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27442", "l": "NAD(+) + xylitol => D-xylose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64011", "l": "(4R)-hydroxysphinganine + hexadecanoyl-CoA <=> CoA + H(+) + N-hexadecanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217150", "l": "Monoubiquitination of FancD2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655848", "l": "Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44525", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-glycerol + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694409", "l": "Nucleotide exchange on RAB1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624953", "l": "ARL13B binds INPP5E (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33901", "l": "FADH2 + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose => FAD + H(+) + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140431", "l": "DNA-(abasic site) binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009979", "l": "16:0 monogalactosyldiacylglycerol desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051034", "l": "tRNA transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864412", "l": "TFAP2A,TFAP2C homodimers bind the CGA gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429529", "l": "Thrombin binding to GP1b:IX:V (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483219", "l": "PC is exchanged with PI by PITPNB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.5.1.-", "l": "\"Carbon-halide lyases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-435244", "l": "PECAM1 is phosphorylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0019209", "l": "kinase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191656", "l": "Closure of gap junction (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204392", "l": "Basigin binds MCT1, MCT3 and MCT4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32176", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose => alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21207", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol <=> a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1006143", "l": "CD46 binds C3b (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195251", "l": "Assembly of the destruction complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655852", "l": "Expression of Lathosterol Oxidase (SC5D, SC5DL) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937022", "l": "IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2995334", "l": "COX15 transforms heme O to heme A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953037", "l": "E2F8 forms homodimers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674140", "l": "PAQR3 binds inactive RAFs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16472", "l": "(R)-2-benzylsuccinate + succinyl-CoA <=> (R)-2-benzylsuccinyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41160", "l": "1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40681", "l": "1-O-(9Z)-octadecenylglycerone 3-phosphate + H(+) + hexadecanoate => (9Z)-octadecen-1-ol + 1-hexadecanoylglycerone 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018758", "l": "RHOH binds effectors at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50657", "l": "3-(2-methylsulfanyl)ethylmalate => 2-(2-methylsulfanyl)ethylmaleate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12889", "l": "L-gulonate + NAD(+) = 3-dehydro-L-gulonate + H(+) + NADH"}, {"i": "EC:1.1.1.45", "l": "\"L-gulonate 3-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632038", "l": "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018775", "l": "2-hydroxymuconate-semialdehyde hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712081", "l": "ALK fusions bind FRS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61437", "l": "ADP + H2O => AMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35342", "l": "3-hydroxyicosanoyl-CoA + NADP(+) <=> 3-oxoeicosanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102366", "l": "7-beta-hydroxytaxusin 2-alpha-hydroxylase activity"}, {"i": "MetaCyc:RXN-13487"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14584", "l": "H(+) + 2 monodehydro-L-ascorbate radical + NADH <=> 2 L-ascorbate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17509", "l": "H2O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372719", "l": "aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47375", "l": "a quinone + D-glucose <=> a quinol + D-glucono-1,5-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018553", "l": "3-(2,3-dihydroxyphenyl)propionate 1,2-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10917", "l": "(1R,2R,3R)-prephytoene diphosphate => all-trans-phytoene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49511", "l": "phosphinomethylmalate <=> 2-(phosphinatomethylidene)butanedioate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54156", "l": "2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013006", "l": "RHOA:GTP translocates to the ER membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12020", "l": "a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.141", "l": "\"4-alpha-D-((1->4)-alpha-D-glucano)trehalose trehalohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798257", "l": "PTPRS binds NTRK3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25154", "l": "3-phenylpyruvate + L-glutamate => 2-oxoglutarate + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614933", "l": "ACEIs bind ACE (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0004301", "l": "epoxide hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211206", "l": "Translocation of DFF to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49783", "l": "docosanoyl-CoA + glycine <=> CoA + H(+) + N-docosanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45004", "l": "(R)-carnitine + 2,6-dimethylheptanoyl-CoA = CoA + O-2,6-dimethylheptanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005516", "l": "calmodulin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33258", "l": "2-demethylmenaquinol-7 + S-adenosyl-L-methionine <=> H(+) + menaquinol-7 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22462", "l": "a 2,3-dehydroacyl-CoA + H(+) + NADPH => a 2,3-saturated acyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534096", "l": "METAP1/2 demethylates GNAT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36518", "l": "H(+) + malonyl-CoA + tetracosanoyl-CoA <=> 3-oxohexacosanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072544", "l": "L-DOPA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21812", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.23", "l": "\"Cholesterol 7-alpha-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852324", "l": "GTSE1 binds PLK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140613", "l": "P-type manganese transporter activity"}, {"i": "RHEA:66820", "l": "ATP + H2O + Mn(2+)(in) = ADP + H(+) + Mn(2+)(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693243", "l": "RHOD translocates to the Golgi membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49138", "l": "H2O + L-methionyl-S-oxide-[protein] + NADP(+) => H(+) + L-methionyl-[protein] + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36527", "l": "(11Z)-eicosenoyl-CoA + H(+) + malonyl-CoA = (13Z)-3-oxodocosenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46299", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0016531", "l": "copper chaperone activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60189", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11277", "l": "4 hydroquinone + O2 => 4 benzosemiquinone + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11961", "l": "2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate => (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33928", "l": "4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2 => 2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58645", "l": "N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine => (9Z,12Z,15Z)-octadecatrienamide + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210881", "l": "Dimerization of Tie2/Ang1 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202731", "l": "JAM3 dimerises (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419841", "l": "Light stimulates opsin receptors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29074", "l": "a ubiquinone + formate + H(+) <=> a ubiquinol + CO2"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0022821", "l": "potassium ion antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63538", "l": "[des-Phe(8), des-Arg(9)]-bradykinin + L-phenylalanine => [des-Arg(9)]-bradykinin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203553", "l": "eNOS binds NOSIP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12258", "l": "CO2 + L-tyrosine + NADH => L-arogenate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14337", "l": "3'-phosphoadenylyl sulfate + UDP-N-acetyl-alpha-D-galactosamine 4-sulfate = adenosine 3',5'-bisphosphate + H(+) + UDP-N-acetyl-alpha-D-galactosamine 4,6-bissulfate"}, {"i": "EC:2.8.2.7", "l": "\"UDP-N-acetylgalactosamine-4-sulfate sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31773", "l": "11-cis-retinol + a fatty acid + H(+) => an all-trans-retinyl ester + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41199", "l": "1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39747", "l": "cholesterol(in) = cholesterol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46378", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17907", "l": "3-hydroxypyruvate + H(+) + NADH => (R)-glycerate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61845", "l": "solasodine + UDP-alpha-D-glucose => H(+) + solasodine 3-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-947514", "l": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43017", "l": "an S-alkyl-L-cysteine => 2-aminoprop-2-enoate + an alkyl thiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418662", "l": "Src activation following P2Y purinoceptor activation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47104", "l": "5,10-methylenetetrahydromethanopterin + glycine + H2O = 5,6,7,8-tetrahydromethanopterin + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50009", "l": "6-methylpretetramide + 2 H(+) + NADPH + O2 => 4-hydroxy-6-methylpretetramide + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3132753", "l": "Pancreatic proteases degrade TCN1:Cbl (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12641", "l": "(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH"}, {"i": "EC:1.1.1.95", "l": "\"Phosphoglycerate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25634", "l": "laricitrin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + syringetin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36972", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-allose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11189", "l": "3-cyano-L-alanine + 2 H2O => L-aspartate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374337", "l": "Apelin receptor binds to apelin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803998", "l": "Nitrite ion and HNO2 form a conjugated acid-base pair (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641206", "l": "RSPOs bind LGRs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433395", "l": "Dimerization of sSCF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790022", "l": "Expression of STAT3-upregulated plasma membrane proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2129375", "l": "Elastin cross-linking by lysyl oxidase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102426", "l": "myricetin-3-O-glucoside 1,6-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-13823"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592236", "l": "NRF1:p-PPARGC1A, NRF2 bind the TFB1M promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035281", "l": "NR1H3 gene transcription regulated by NR1H2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202721", "l": "JAM2 binds JAM3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.182", "l": "\"4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28542", "l": "fluoroacetyl-CoA + H2O = CoA + fluoroacetate + H(+)"}, {"i": "EC:3.1.2.29", "l": "\"Fluoroacetyl-CoA thioesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683831", "l": "CCDC59 binds TTF1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990856", "l": "methionyl-initiator methionine tRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19081", "l": "1-haloalkane + H2O = a halide anion + a primary alcohol + H(+)"}, {"i": "RHEA:25185", "l": "1,2-dichloroethane + H2O = 2-chloroethanol + chloride + H(+)"}, {"i": "EC:3.8.1.5", "l": "\"Haloalkane dehalogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375140", "l": "CDO binds promyogenic cadherins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14975", "l": "D-aspartate => L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2299725", "l": "PGH2 diffuses from the endoplasmic reticulum lumen to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44982", "l": "CoA + O-butanoyl-(R)-carnitine => (R)-carnitine + butanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419843", "l": "CALCA(83-119) binds CALCR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102790", "l": "cyanidin 5,3-O-glycosyltransferase activity"}, {"i": "MetaCyc:RXN-8006"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8963734", "l": "IL9 binds IL9R:JAK1 and IL2RG:JAK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112703", "l": "PTPN11 is phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61131", "l": "O2 + quercetin + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + myricetin + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43204", "l": "cytidine(1409) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1409) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.227", "l": "\"16S rRNA (cytidine(1409)-2'-O)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.99.4"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001566", "l": "non-kinase phorbol ester receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50321", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] => 1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50222", "l": "(R)-demethyl-4-deoxygadusol => (S)-demethyl-4-deoxygadusol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55396", "l": "(R)-carnitine + H(+) + NADH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21195", "l": "D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O <=> D-galactosyl-N-acetyl-beta-D-galactosamine + L-serine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018789", "l": "cyclamate sulfohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24303", "l": "2 cob(I)yrinate a,c diamide + FMN + 3 H(+) <=> 2 cob(II)yrinate a,c diamide + FMNH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39400", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA => (2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25478", "l": "alpha-himachalene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35517", "l": "CoA + salvianin => 4'''-demalonylsalvianin + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109813", "l": "GRB2-1 binds SOS1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65377", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidyl-adenosine in mRNA + 2 S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidyl-adenosine in mRNA + H(+) + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043814", "l": "phospholactate guanylyltransferase activity"}, {"i": "RHEA:63424", "l": "(2S)-2-phospholactate + GTP + H(+) = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate"}, {"i": "EC:2.7.7.68", "l": "\"2-phospho-L-lactate guanylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65777", "l": "chlorotoluron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-(3-chloro-4-methylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28166", "l": "5-nitroanthranilate + H(+) + H2O = 5-nitrosalicylate + NH4(+)"}, {"i": "EC:3.5.99.8", "l": "\"5-nitroanthranilic acid aminohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57694", "l": "2 cob(I)inamide--[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein] => 2 cob(II)inamide--[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.26"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-744231", "l": "SLC35D2 exchanges UDP-sugars for UMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5250947", "l": "B-WICH complex binds rDNA promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035639", "l": "purine ribonucleoside triphosphate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39575", "l": "3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50336", "l": "O2 + reduced [NADPH--hemoprotein reductase] + triacontanoate = H(+) + H2O + omega-hydroxy-triacontanoate + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36873", "l": "3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + CO2 + CoA => (19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167087", "l": "Limited elongation of the HIV-1 transcript (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45736", "l": "(3E)-hexenoyl-CoA = (2E)-hexenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45300", "l": "an N-(acyl)-sphingosylphosphocholine + H2O = an N-acyl-sphingoid base + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63188", "l": "3,4-dihydroxybenzaldehyde + AH2 + tyramine = A + H2O + norbelladine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382056", "l": "Crk binds to the active PDGF receptor (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38616", "l": "cyclic ADP-ribose + H2O => ADP-D-ribose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418904", "l": "A1 and A3 receptors bind adenosine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203712", "l": "eNOS associates with Caveolin-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47120", "l": "docosanoate + glycine = H2O + N-docosanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41409", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30966", "l": "7,9,9'-tri-cis-neurosporene + a quinone <=> 7,7',9,9'-tetra-cis-lycopene + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26313", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate = dihydroxyacetone phosphate + L-aspartate 4-semialdehyde"}, {"i": "EC:4.1.2.56", "l": "\"2-amino-4,5-dihydroxy-6-oxo-7-(phosphonooxy)heptanoate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18305", "l": "acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-4-O-acetylneuraminate"}, {"i": "EC:2.3.1.44", "l": "\"N-acetylneuraminate 4-O-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004979", "l": "beta-endorphin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36639", "l": "3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-methionine = 3-O-methylphospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.294", "l": "\"3-O-phospho-polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 3-phospho-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693783", "l": "NAALADases hydrolyse NAAG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28514", "l": "(R)-carnitine + ATP + CoA = (R)-carnitinyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41280", "l": "H2O + N-octadecanoylsphing-4-enine => octadecanoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38589", "l": "devancoaminyl-vancomycin + UDP => UDP-alpha-D-glucose + vancomycin aglycone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5333678", "l": "CPNEs bind PL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43511", "l": "2,5-diformylfuran + H2O <=> 2-(dihydroxymethyl)-5-formylfuran"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66177", "l": "ATP + H2O + taurochenodeoxycholate 3-sulfate(in) => ADP + H(+) + phosphate + taurochenodeoxycholate 3-sulfate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48700", "l": "H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol = a fatty acid + H(+) + long chain acyl-3-O-beta-D-galactosyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051722", "l": "protein C-terminal methylesterase activity"}, {"i": "REACT:R-HSA-8856951", "l": "PP2A demethylation by PPME1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44105", "l": "decanal + H2O + NAD(+) => decanoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863011", "l": "p25-bound CDK5 phosphorylates CDC25C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64698", "l": "benzaldehyde + H(+) + NADH => benzyl alcohol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35422", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> an anthocyanidin 3-O-sophoroside + 2 H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102833", "l": "sequoyitol galactinol:D-galactosylononitol galactosyltransferase activity"}, {"i": "MetaCyc:RXN-8292"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211983", "l": "CYP2J2 oxidises ARA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.9", "l": "\"N-acylglucosamine-6-phosphate 2-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390673", "l": "CHRM2,4 bind acetylcholine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801355", "l": "TP53 binds the NLRC4 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38082", "l": "2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA <=> 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2002401", "l": "Association of procollagen type XVIII (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.34"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696465", "l": "USP45 deubiquitinates ERCC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030697", "l": "S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity"}, {"i": "MetaCyc:TRNA-URACIL-5--METHYLTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55102", "l": "(3R)-hydroxypentanoyl-[ACP] + NADP(+) => 3-oxopentanoyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59245", "l": "3''-O-acetyl-ADP-D-ribose + H2O => acetate + ADP-D-ribose + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047561", "l": "3-hydroxyanthranilate oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5660660", "l": "p300 acetylates RELA subunit (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0004985", "l": "G protein-coupled opioid receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65457", "l": "2-methylbutan-1-ol + acetyl-CoA => 2-methylbutyl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26010", "l": "2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) = 3,7-dideoxy-D-threo-hepto-2,6-diuolosonate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21355", "l": "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 <=> (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023132", "l": "AURKB phosphorylates MECP2 at S423 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44294", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + CDP-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166387", "l": "The FA anion diffuses away laterally from UCP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57618", "l": "dihydro-ML-236C carboxylate + H(+) + holo-[compactin nonaketide synthase] => dihydro-ML-236C-[compactin nonaketide synthase] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44724", "l": "2,3-saturated fatty aldehyde + NADP(+) = (2E)-fatty aldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21015", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine <=> 4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26316", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate <=> dihydroxyacetone phosphate + L-aspartate 4-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40013", "l": "diphosphate + manool => (+)-copalyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103099", "l": "UDP-glucose:5-methylthiopentylhydroximate S-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54550", "l": "D-xylulose 5-phosphate + phosphate => D-xylulose 1,5-bisphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11419", "l": "2 1-O-galloyl-beta-D-glucose <=> 1,6-bis-O-galloyl-beta-D-glucose + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31881", "l": "beta-seco-amyrin => (S)-2,3-epoxysqualene"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034322", "l": "alcohol O-decanoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40331", "l": "1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP = 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63586", "l": "2-deoxyecdysone + phosphate => 2-deoxyecdysone 22-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36508", "l": "docosanoyl-CoA + H(+) + malonyl-CoA => 3-oxotetracosanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61508", "l": "peonidin + UDP-alpha-D-glucose = peonidin 3-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83660", "l": "Membrane-anchored TNF-alpha binds TNFR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58515", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080105", "l": "6-methylthiopropyl glucosinolate S-oxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8856951", "l": "PP2A demethylation by PPME1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018596", "l": "dimethylsilanediol hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60735", "l": "H2O + NADP(+) + perillyl aldehyde <=> 2 H(+) + NADPH + perillate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018689", "l": "naphthalene disulfonate 1,2-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018798", "l": "RHOV binds GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420083", "l": "PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53546", "l": "7(1)-hydroxychlorophyll a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => chlorophyll a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65135", "l": "2-oxoglutarate + O2 + preaustinoid A1 <=> CO2 + H2O + preaustinoid A2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14539", "l": "1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH4(+) => 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59977", "l": "2-phenylacetate + H(+) => CO2 + toluene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54173", "l": "H2O + N(6)-acyl-L-lysyl-[protein] + NAD(+) => L-lysyl-[protein] + nicotinamide + O-acyl-ADP-D-ribose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5666001", "l": "Profilin:G-actin binds MKL1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73797", "l": "FAICAR => IMP + H2O (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35948", "l": "dihydrochanoclavine-I aldehyde + NADP(+) => chanoclavine-I aldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40029", "l": "(13S)-vitexifolin A + diphosphate => 9alpha-copalyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48286", "l": "globoside NOR1 (d18:1(4E)) + H(+) + UDP => globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25418", "l": "(9Z)-octadecenoyl-CoA + A + 2 H2O => AH2 + O2 + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49366", "l": "17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + diphosphate => 17-(4-hydroxyphenyl)heptadecanoate + ATP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956031", "l": "NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196929", "l": "FLAD1 phosphorylates FMN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31047", "l": "(S)-methylmalonate semialdehyde + CoA + NAD(+) = CO2 + NADH + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382053", "l": "Translocation of PDGF from ER to Golgi (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37661", "l": "CoA + O-methyl anthranilate => anthraniloyl-CoA + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42554", "l": "pseudouridine(31) in tRNA => uridine(31) in tRNA"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0008308", "l": "voltage-gated anion channel activity"}, {"i": "REACT:R-HSA-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48901", "l": "chlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] => 3,8-divinyl chlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15589", "l": "2-oxoglutarate + D-4-hydroxyphenylglycine = 4-hydroxyphenylglyoxylate + L-glutamate"}, {"i": "EC:2.6.1.72", "l": "\"D-4-hydroxyphenylglycine transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22853", "l": "L-serine + pyruvate => 3-hydroxypyruvate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15403", "l": "dolichyl beta-D-glucosyl phosphate + UDP => dolichyl phosphate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46470", "l": "ADP + an N-(acyl)-sphingosylphosphocholine(out) + H(+) + phosphate => an N-(acyl)-sphingosylphosphocholine(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15592", "l": "2-oxoglutarate + D-4-hydroxyphenylglycine <=> 4-hydroxyphenylglyoxylate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57447", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O <=> C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0008320", "l": "protein transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10120", "l": "adenosine in double-stranded RNA + H(+) + H2O = inosine in double-stranded RNA + NH4(+)"}, {"i": "EC:3.5.4.37", "l": "\"Double-stranded RNA adenine deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021520", "l": "NOTCH3 binds WWP2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46569", "l": "5-hexenoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 5-hexynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047203", "l": "13-hydroxylupinine O-tigloyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42339", "l": "[thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> [thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "81.20444558259193", "identifiers": [{"i": "GO:0016742", "l": "hydroxymethyl-, formyl- and related transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008256", "l": "protein histidine pros-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52433", "l": "(R)-2,3-diaminopropanoate + H(+) + H2O => 2 NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43294", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53031", "l": "lithocholate + UDP-alpha-D-glucuronate <=> H(+) + lithocholoyl-3-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917841", "l": "Acidification of Tf:TfR1 containing endosome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46874", "l": "a 2-acyl-sn-glycero-3-phosphocholine + lipid IIB => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59330", "l": "D-xylonate + H(+) => D-xylono-1,5-lactone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44006", "l": "a 3-methyl fatty acyl-CoA + AMP + diphosphate => 3-methyl fatty acid + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018794", "l": "RHOV binds effectors at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31322", "l": "(2R)-3-phosphoglycerate + UDP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046180", "l": "KSPG is secreted from the cell (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-507870", "l": "Aquaporins passively transport water out of cells (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35438", "l": "cyanidin 3-O-beta-D-galactoside + UDP-alpha-D-xylose <=> cyanidin 3-O-[beta-D-xylosyl-(1->2)-beta-D-galactoside] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786650", "l": "DDHD1,2 hydrolyse PA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25197", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O = 5-amino-6-(D-ribitylamino)uracil + phosphate"}, {"i": "EC:3.1.3.104", "l": "\"5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13559", "l": "ADP + glutathione + H(+) + phosphate => ATP + glycine + L-gamma-glutamyl-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0031491", "l": "nucleosome binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36083", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15231", "l": "diphosphate + GDP-alpha-D-mannose => alpha-D-mannose 1-phosphate + GTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018547", "l": "nitroglycerin reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418858", "l": "RhoGTPase GEF's recruited to DCC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029992", "l": "Tyrosine kinase inhibitors bind to overexpressed FGFR2 variants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624954", "l": "INPP5E translocates to the primary cilium (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.2.-", "l": "\"With a cytochrome as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42591", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49897", "l": "(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate => 5,10-dihydrophenazine-1,6-dicarboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47353", "l": "a hexanoate ester + H2O => an aliphatic alcohol + H(+) + hexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.131", "l": "\"Xylan alpha-1,2-glucuronosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449117", "l": "TXLNA (IL14) binds syntaxin1A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29883", "l": "ATP + H2O + L-ornithine(out) = ADP + H(+) + L-ornithine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50997", "l": "L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55643", "l": "C-terminal L-cysteinyl-[HypE protein] + carbamoyl adenylate <=> AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28454", "l": "N(6)-(D-fructosyl)-L-lysine(in) = N(6)-(D-fructosyl)-L-lysine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11947", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + 2 H2O <=> 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + 2 chloride + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "73.344328060803463", "identifiers": [{"i": "GO:0001067", "l": "transcription regulatory region nucleic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47414", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + CoA => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64594", "l": "a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004150", "l": "dihydroneopterin aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29514", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-valencene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35921", "l": "H(+) + kanamycin D + UDP => 2'-deamino-2'-hydroxyneamine + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29547", "l": "H2O + UDP-N-acetyl-alpha-D-glucosamine = 2 H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865482", "l": "KMT2A (MLL) binds RUNX1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372903", "l": "lactate + NAD+ <=> pyruvate + NADH + H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17397", "l": "a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH"}, {"i": "EC:1.1.1.100", "l": "\"3-oxoacyl-[acyl-carrier-protein] reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655351", "l": "Activated FGFR4 mutants bind FRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47152", "l": "2,5-dioxopentanoate + H2O + NAD(+) = 2-oxoglutarate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.170", "l": "\"2-(omega-methylthio)alkylmalate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033770", "l": "2-hydroxyisoflavanone synthase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008782", "l": "adenosylhomocysteine nucleosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24912", "l": "2-aminobut-2-enoate + L-cysteine => L,L-cystathionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102980", "l": "2-butyl-4-hydroxy-5-methyl-3(2H)-furanoneoxidoreductase activity"}, {"i": "MetaCyc:RXN-9565"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204873", "l": "Interaction of Tie2 and Shp2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0052592", "l": "oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor"}, {"i": "EC:1.17.7.-", "l": "\"With an iron-sulfur protein as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38906", "l": "a sphingomyelin(in) + ATP + H2O <=> a sphingomyelin(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218832", "l": "CDC42:GTP binds PAK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65225", "l": "(1R,2R)-1,2-dihydronaphthalene-1,2-diol + NADP(+) => H(+) + NADPH + naphthalene-1,2-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49055", "l": "asperlicin C + H(+) + NADH + O2 <=> asperlicin E + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1011598", "l": "DOCKs bind to RhoGEFs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29039", "l": "ATP + H2O + L-aspartate(out) = ADP + H(+) + L-aspartate(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37565", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA => (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28902", "l": "glycine(in) + H(+)(in) <=> glycine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879221", "l": "PSTPIP1 binds Pyrin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159771", "l": "Furin cleaves pro-protein C to protein C (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28177", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate <=> colneleate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23632", "l": "D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64159", "l": "an N-(fatty acyl)-L-methionine + H2O <=> a fatty acid + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1247922", "l": "GGCT transforms gGluCys to OPRO (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374298", "l": "Opioid receptors bind opioid peptides (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507719", "l": "p62:MEKK3 binds to TRAF6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694409", "l": "Nucleotide exchange on RAB1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62584", "l": "ATP + H2O + L-tyrosine(out) = ADP + H(+) + L-tyrosine(in) + phosphate"}, {"i": "EC:7.4.2.13", "l": "\"ABC-type tyrosine transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381668", "l": "cAMP activates EPAC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11163", "l": "2-oxoglutarate + L-2,4-diaminobutanoate <=> L-aspartate 4-semialdehyde + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14932", "l": "NAD(+) + testosterone <=> androst-4-ene-3,17-dione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102367", "l": "2-alpha-hydroxytaxusin 7-beta-hydroxylase activity"}, {"i": "MetaCyc:RXN-13488"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46330", "l": "3-phenylpyruvate + NH4(+) => L-threo-3-phenylserine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33945", "l": "4 H2O + 2 L-citrulline + 3 NAD(+) + 2 nitric oxide => H(+) + 2 L-arginine + 3 NADH + 4 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202164", "l": "Translocation of PDK1 to Plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37905", "l": "H(+) + S-adenosyl-L-homocysteine + tryprostatin A => 6-hydroxytryprostatin B + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15960", "l": "D-altronate <=> 2-dehydro-3-deoxy-D-gluconate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46257", "l": "2 [Fe(II)-cytochrome b5] + a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981926", "l": "RAC1 and CDC42 activate PAK3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592297", "l": "Full activation of MMP1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174157", "l": "Degradation of multiubiquitinated Cyclin B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5679205", "l": "ULK1 phosphorylates Beclin-1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21198", "l": "L-methionine + tetrahydropteroyltri-L-glutamate => 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41435", "l": "3-methyl-L-tyrosine + H2O2 <=> 5-hydroxy-3-methyl-L-tyrosine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59039", "l": "4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53618", "l": "(+)-isoafricanol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64262", "l": "CoA + H(+) + N-(9Z,12Z-octadecadienoyl)-glycine => (9Z,12Z)-octadecadienoyl-CoA + glycine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004946", "l": "bombesin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730841", "l": "Phosphorylation and activation of VAV (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9009309", "l": "RUNX2 binds STUB1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199093", "l": "CXADR binds to AMICA1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17287", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51444", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-leucine = H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.25.1", "l": "\"Proteasome endopeptidase complex\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080068", "l": "5-methylthiopentyl-desulfoglucosinolate sulfotransferase activity"}, {"i": "MetaCyc:RXNQT-4330"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24147", "l": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA <=> 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39311", "l": "(8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41773", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) => CMP + ganglioside GQ1b (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5339713", "l": "Misspliced GSK3beta mutants stabilize beta-catenin levels (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65197", "l": "H2O + NAD(+) + S-(2-aminoethyl)-L-cysteine => H(+) + NADH + NH4(+) + S-(acetaldehyde)-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27626", "l": "D-erythrose 4-phosphate + D-xylulose 5-phosphate = beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806974", "l": "MET dimers autophosphorylate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43620", "l": "L-serine + NADP(+) = aminoacetaldehyde + CO2 + NADPH"}, {"i": "EC:1.1.1.276", "l": "\"Serine 3-dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863727", "l": "STON2 is neddylated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15897", "l": "4-acetamidobutanoate + H2O = 4-aminobutanoate + acetate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001864", "l": "pentraxin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2059926", "l": "NPHP4 protein binds LATS proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244500", "l": "botE:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1678843", "l": "ISGylation of protein translation regulator 4EHP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050484", "l": "GMP 5'-nucleotidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16140", "l": "2'-deoxymugineate + NADP(+) <=> 3''-deamino-3''-oxonicotianamine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21701", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O => 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34382", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 UDP-alpha-D-galactofuranose <=> beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 H(+) + 2 UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31606", "l": "(Z)-3-ureidoacrylate + H2O <=> (Z)-3-aminoacrylate + carbamate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22420", "l": "cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD(+) = 2 H(+) + maleylacetate + NADH"}, {"i": "EC:1.2.1.61", "l": "\"4-hydroxymuconic-semialdehyde dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851933", "l": "MET phosphorylates GAB1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40239", "l": "ATP + CoA + dodecanedioate = AMP + diphosphate + dodecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34012", "l": "ergosta-5,7,24(28)-trien-3beta-ol + 2 H2O + NADP(+) => ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192061", "l": "CYP46A1 24-hydroxylates CHOL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63951", "l": "H2O + sphinga-4E,14Z-dienine-1-phosphate <=> phosphate + sphinga-4E,14Z-dienine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804242", "l": "TP53 binds the complex of JMY, EP300 and TTC5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66123", "l": "2-oxobutanoate + L-methionine <=> (2S)-2-aminobutanoate + 4-methylsulfanyl-2-oxobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67170", "l": "3-(3-hydroxyphenyl)pyruvate + L-glutamate => 2-oxoglutarate + 3-hydroxy-L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072591", "l": "citrate-L-glutamate ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437139", "l": "ZnT6 transports zinc into the golgi apparatus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160915", "l": "Receptor-mediated uptake of HA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019778", "l": "Atg12 activating enzyme activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229194", "l": "Depolymerization of lamin filaments after PKC-mediated phosphorylation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.79"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53076", "l": "cytidine(34) in mitochondrial tRNA + S-adenosyl-L-methionine = 5-methylcytidine(34) in mitochondrial tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16415", "l": "(R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + L-lysyl-[glycine-cleavage complex H protein] => L-lysyl-[lipoyl-carrier protein] + N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9006844", "l": "IL21:IL21R:JAK1 binds IL2RG:JAK3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21081", "l": "ATP + H2O + L-methionine => diphosphate + phosphate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48175", "l": "ganglioside GM2 + H2O <=> N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11982", "l": "bis-gamma-glutamylcystine + H(+) + NADPH => 2 L-gamma-glutamyl-L-cysteine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27363", "l": "chloromethane + S-adenosyl-L-homocysteine => chloride + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449058", "l": "Interleukin-1 family are secreted (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17949", "l": "3-hydroxy-1H-quinolin-4-one + O2 = CO + H(+) + N-formylanthranilate"}, {"i": "EC:1.13.11.47", "l": "\"3-hydroxy-4-oxoquinoline 2,4-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6801675", "l": "PLK2 phosphorylates NPM1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50861", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 => 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39685", "l": "(R)-3-hydroxy-(11Z)-octadecenoyl-CoA + NADP(+) => 3-oxo-(11Z)-octadecenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49836", "l": "(5E)-tetradecenoyl-CoA + (R)-carnitine = (5E)-tetradecenoyl-(R)-carnitine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58580", "l": "dihydroprecondylocarpine acetate = acetate + catharanthine + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047495", "l": "membrane-oligosaccharide glycerophosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853444", "l": "AURKA phosphorylates PHLDA1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18117", "l": "L-tyrosine + O2 = H2O + L-dopaquinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395764", "l": "atREs binds to nascent CM (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.178", "l": "\"Beta-porphyranase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60437", "l": "3-methylbutyl acetate + H2O => 3-methylbutanol + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444433", "l": "Cho transports from the extracellular space to the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76456", "l": "O-atom dealkylation of dextromethorphan (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114683", "l": "Phosphorylation of Platelet Sec-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54010", "l": "(8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65062", "l": "7-oxotaurolithocholate + H(+) + NADPH => NADP(+) + taurochenodeoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626988", "l": "TNF-alpha:TNFR1 binds NSMAF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42934", "l": "2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(32) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5591086", "l": "SERPINA5 binds activated protein C (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66648", "l": "(2E,6E)-farnesyl diphosphate = african-3-ene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.98"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60462", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) => (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9681616", "l": "AP2 binds chlorpromazine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14048", "l": "1-carboxyvinyl carboxyphosphonate + H(+) <=> 3-(hydrohydroxyphosphoryl)pyruvate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63661", "l": "(S)-8-amino-7-oxononanoate + CO2 + L-lysyl-[protein] => (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10529", "l": "dihydrosanguinarine + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxydihydrosanguinarine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "57.032212537078479", "identifiers": [{"i": "GO:0016301", "l": "kinase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061769", "l": "ribosylnicotinate kinase activity"}, {"i": "REACT:R-HSA-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Homo sapiens)"}, {"i": "REACT:R-HSA-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42409", "l": "(2R)-2-phosphoglycerate + ATP => (2R)-2,3-bisphosphoglycerate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29011", "l": "2-oxoglutarate(in) + H(+)(in) = 2-oxoglutarate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65243", "l": "(11Z)-octadecenoyl-CoA + H2O <=> (11Z)-octadecenoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956031", "l": "NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43977", "l": "H(+) + hexadecanoate + NADPH + O2 => 14-hydroxyhexadecanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008701", "l": "4-hydroxy-2-oxovalerate aldolase activity"}, {"i": "RHEA:22624", "l": "(S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate"}, {"i": "EC:4.1.3.39", "l": "\"4-hydroxy-2-oxovalerate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961863", "l": "E2F1 binds the DHFR gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22694", "l": "2,5-dihydroxybenzoate + H2O + NAD(+) => 3-hydroxybenzoate + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77094", "l": "Formation of cap binding complex (CBC) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50951", "l": "a 2'-deoxycytidine in single-stranded DNA + H(+) + H2O <=> a 2'-deoxyuridine in single-stranded DNA + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004828", "l": "serine-tRNA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39986", "l": "2 [Fe(II)-cytochrome b5] + a 1,2-saturated fatty acid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a 2-hydroxy fatty acid + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047427", "l": "cyanoalanine nitrilase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10939", "l": "6-decylubiquinone + 2 thiosulfate <=> 6-decylubiquinol + tetrathionate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23275", "l": "an N(6)-alkylaminopurine + UDP-alpha-D-glucose <=> an N(6)-alkylamino-7-beta-D-glucosylpurine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2327746", "l": "FN1 aggregation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14531", "l": "ADP-D-ribose + phosphate => ADP + D-ribose 5-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64672", "l": "2-(methylsulfanyl)acetyl-CoA + butan-1-ol = butyl 2-(methylsulfanyl)acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0052590", "l": "sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46611", "l": "ATP + L-threonyl-[protein] <=> ADP + H(+) + O-phospho-L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48185", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31801", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+) => 4-amino-5-aminomethyl-2-methylpyrimidine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43475", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103006", "l": "9,10-dihydroxystearate hydroxylase activity"}, {"i": "MetaCyc:RXN-9807"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62334", "l": "adenosine 3'-diphosphate,5'-diphosphate + AMP => ADP + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693061", "l": "STAMBP binds STAM (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20771", "l": "3-phosphonopyruvate + H(+) <=> CO2 + phosphonoacetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65436", "l": "a 5'-end triphospho-adenylyl-adenylyl-cytidyl-adenosine in mRNA + GDP + H(+) = a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidyl-adenosine in mRNA + diphosphate"}, {"i": "EC:2.7.7.88", "l": "\"GDP polyribonucleotidyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847534", "l": "RAB43 hydrolyses GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0030515", "l": "snoRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15277", "l": "acetyl-CoA + L-lysyl-[alpha-tubulin] = CoA + H(+) + N(6)-acetyl-L-lysyl-[alpha-tubulin]"}, {"i": "EC:2.3.1.108", "l": "\"Alpha-tubulin N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16612", "l": "AMP + diphosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + adenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20061", "l": "2'-deoxycytidine + a ribonucleoside 5'-triphosphate = a ribonucleoside 5'-diphosphate + dCMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799409", "l": "HIPK2 phosphorylates TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102965", "l": "alcohol-forming fatty acyl-CoA reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804879", "l": "MDM2 ubiquitinates TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28980", "l": "H(+)(out) + nitrite(in) => H(+)(in) + nitrite(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651789", "l": "LIG1 bound to POLB ligates SSB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49585", "l": "D-erythrulose 1-phosphate => L-erythrulose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28703", "l": "Cu(2+)(in) = Cu(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625346", "l": "SREBF1 gene expression is inhibited by FOXO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070856", "l": "myosin VI light chain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40050", "l": "1,2,3-trioctanoylglycerol + H2O <=> 1,2-dioctanoyl-sn-glycerol + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9663511", "l": "BIL binds GSTA1, FABP1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29041", "l": "ADP + H(+) + L-aspartate(in) + phosphate => ATP + H2O + L-aspartate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349455", "l": "Phosphorylation of MDM4 by ATM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853429", "l": "PHLDA1 binds AURKA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44926", "l": "(R)-dihomocitrate + CoA + H(+) => 2-oxoadipate + acetyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24521", "l": "H2O + L-saccharopine + NAD(+) => (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9680443", "l": "ROCK1,2 bind ROCKi (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10827", "l": "(S)-malate + NADP(+) <=> H(+) + NADPH + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74258", "l": "XDH oxidizes xanthine to form urate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55897", "l": "chloride + FADH2 + L-tryptophan + O2 => 5-chloro-L-tryptophan + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74712", "l": "Dissociation of IRS-P from insulin receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733960", "l": "Bile salts and acids dissociate from ALB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170149", "l": "Translocation of active Cdc25C to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14479", "l": "a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.2", "l": "\"Chymotrypsin C\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23545", "l": "a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-alpha-D-glucose => a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44698", "l": "a fatty acid + H(+) + sn-glycerol 3-phosphocholine => a 2-acyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050020", "l": "L-arabinonate dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624985", "l": "CAV1 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047458", "l": "beta-pyrazolylalanine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19440", "l": "nicotinate + UDP-alpha-D-glucose <=> N-(beta-D-glucosyl)nicotinate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014812", "l": "ROBOs bind keratan sulfate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534260", "l": "E-cadherin degradation by caspase-3 and calpain-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1972385", "l": "ADP-Ribosylation of HNP-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701485", "l": "Active ALK binds JAK3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38278", "l": "(3R)-citramalyl-CoA <=> acetyl-CoA + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38394", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59038", "l": "4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30464", "l": "(2Z,6Z)-farnesyl diphosphate => (+)-alpha-santalene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.173"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190260", "l": "FGFR2b binds to FGF (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65773", "l": "2 H(+) + isoproturon + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1-methyl-3-[4-(propan-2-yl)phenyl]urea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031851", "l": "kappa-type opioid receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848829", "l": "CBL autoubiquitinates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58343", "l": "beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O <=> chenodeoxycholate + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39536", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA => (2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66513", "l": "1-acyl-2-(9Z,12Z-octadecadienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27684", "l": "ADP + dTTP => ATP + dTDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.6.2.12", "l": "\"ABC-type capsular-polysaccharide transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24107", "l": "7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA <=> 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18756", "l": "[protein]-dithiol + NADP(+) <=> [protein]-disulfide + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40687", "l": "1-hexadecanoylglycerone 3-phosphate + tetradecan-1-ol = 1-O-tetradecylglycerone 3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46374", "l": "2 [Fe(III)-cytochrome b5] + a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49744", "l": "deoxyviolaceinate + H(+) + O2 = CO2 + deoxyviolacein + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110307", "l": "REV1 binds AP-dsDNA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23241", "l": "5-formyltetrahydrofolate + L-glutamate => (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614662", "l": "FOXO1,FOXO3,(FOXO4) bind FASLG gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799409", "l": "HIPK2 phosphorylates TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981622", "l": "Myoglobin:oxygen dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0008912", "l": "lactaldehyde reductase activity"}, {"i": "RHEA:15933", "l": "(S)-propane-1,2-diol + NAD(+) = (S)-lactaldehyde + H(+) + NADH"}, {"i": "RHEA:23872", "l": "(R)-propane-1,2-diol + NAD(+) = (R)-lactaldehyde + H(+) + NADH"}, {"i": "EC:1.1.1.77", "l": "\"Lactaldehyde reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791054", "l": "Expression of GSK3A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50803", "l": "glutathione + prostaglandin A2 <=> prostaglandin A2-S-(S)-glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8847534", "l": "RAB43 hydrolyses GTP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034848", "l": "naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362437", "l": "C-terminal Hh fragments are bound by lectins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "78.819800280251172", "identifiers": [{"i": "GO:0050839", "l": "cell adhesion molecule binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54389", "l": "1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26058", "l": "GTP + H(+) + valienol 1-phosphate <=> diphosphate + GDP-valienol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51571", "l": "(25S)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25S)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102983", "l": "xylogalacturonan beta-1,3-xylosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14077", "l": "3-oxopropanoate + L-alanine = beta-alanine + pyruvate"}, {"i": "EC:2.6.1.18", "l": "\"Beta-alanine--pyruvate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218906", "l": "RIPK3 phosphorylates MLKL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194818", "l": "botA LC cleaves target cell SNAP25 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34387", "l": "beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + UDP-alpha-D-galactofuranose = beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64085", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) => 2,3,6,8,9-pentahydroxy-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracen-1-one + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43683", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA <=> 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75238", "l": "TRAIL binds TRAIL receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38659", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5225649", "l": "RBBP7 binds histone H3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.15"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093329", "l": "EFNBs bind SDCBP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12171", "l": "allyl alcohol + NADP(+) <=> acrolein + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2752118", "l": "SPP1 (osteopontin) binds Integrin alpha4beta1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010648", "l": "ROBO2 binds AKAP5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682111", "l": "Defective ABCA1 does not transport CHOL from transport vesicle membrane to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805638", "l": "KAT6A acetylates TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53514", "l": "(13R)-S-cysteinylglycinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + L-glutamate => (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20123", "l": "AMP + diphosphate + L-glutaminyl-tRNA(Gln) => ATP + L-glutamine + tRNA(Gln)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203973", "l": "Vesicle budding (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691335", "l": "nsp7 binds nsp8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42923", "l": "S-adenosyl-L-methionine + uridine(1498) in 16S rRNA <=> H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11928", "l": "hydroxylamine + NH4(+) = H(+) + H2O + hydrazine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624120", "l": "CEBPA binds CDK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38488", "l": "1-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389350", "l": "Activation of Cdc42 by pVav1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26041", "l": "beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + GDP + H(+) => beta-D-fructose 6-phosphate + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10154", "l": "ADP + carbamoyl phosphate + H(+) + H2O => ATP + hydrogencarbonate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45533", "l": "H2O + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018768", "l": "RHOU auto-activates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38674", "l": "sphinganine 1-phosphate(in) <=> sphinganine 1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37214", "l": "2',3'-cyclic GMP + H2O <=> guanosine 2'-monophosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.31", "l": "\"Acyl-lipid (7-3)-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37339", "l": "3-(carbamoylamino)-2-methylpropanoate + 2 H(+) + H2O = (R)-3-amino-2-methylpropanoate + CO2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29084", "l": "(S)-malate + ubiquinone-8 => oxaloacetate + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55510", "l": "11-oxocucurbitadienol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => cucurbitadienol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57236", "l": "GMP + methylglyoxal = N(2)-(1-hydroxy-2-oxopropyl)-GMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672163", "l": "SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014449", "l": "RHOG binds effectors at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37635", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140806", "l": "SERPINC1 binds SERPINC1 activators (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51398", "l": "CoA + H(+) + N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + serotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161563", "l": "PGJ2 is isomerised to delta12-PGJ2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17332", "l": "(1R,2S,4R)-borneol + NAD(+) <=> (1R,4R)-camphor + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211239", "l": "Association of DFF40 with chromatin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16178", "l": "H2O + NAD(+) + retinal => 2 H(+) + NADH + retinoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434084", "l": "p-IRAK2- TRAF6 dissociates from the activated chTLR complex  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419087", "l": "LIM kinase phosphorylation by ROCK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53084", "l": "[(1->2)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->2)-beta-D-glucosyl](n+1) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62029", "l": "H2O + stigmasteryl 3-beta-D-glucoside => D-glucose + stigmasterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624272", "l": "MMPs cleave HB-EGF (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45341", "l": "[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O => (9Z)-hexadecenoate + [Wnt protein]-L-serine + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0030021", "l": "extracellular matrix structural constituent conferring compression resistance"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20698", "l": "H2O2 + O2 => 2 H(+) + 2 superoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56211", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] <=> 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48932", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1b = CMP + ganglioside GQ1b + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64230", "l": "1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22179", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49948", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2 = (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22217", "l": "(E)-caffeate + O2 => 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42690", "l": "A + ergothioneine + NH4(+) + pyruvate => AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13525", "l": "(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] = (1R,4R,5R)-5-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]"}, {"i": "EC:1.14.15.1", "l": "\"Camphor 5-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39858", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycerol <=> a triacyl-sn-glycerol + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-449077", "l": "Interleukin-16 is secreted (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41246", "l": "N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine <=> N-acyl-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoate (4E)-octadecasphin-4-enine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045031", "l": "G protein-coupled ATP receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031802", "l": "type 5 metabotropic glutamate receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102235", "l": "1-penten-3-one reductase activity"}, {"i": "MetaCyc:RXN-12295"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.154"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38683", "l": "ATP + H2O + sphing-4-enine(in) = ADP + H(+) + phosphate + sphing-4-enine(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043863", "l": "4-hydroxy-2-ketopimelate aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62727", "l": "(+)-premalbrancheamide + bromide + FAD + 2 H(+) <=> (+)-isomalbrancheamide C + FADH2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034822", "l": "citronellal dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36895", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + AH2 + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120023", "l": "somatostatin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20307", "l": "4-hydroxybenzoate + 2 H(+) + NADH => 4-hydroxybenzaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33188", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42315", "l": "H(+) + NADP(+) + 2 reduced [adrenodoxin] <=> NADPH + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18467", "l": "5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+) => L-dopa + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.6", "l": "\"Acyl-CoA (9+3)-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5082356", "l": "HSF1-mediated gene expression (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956659", "l": "ABL1 phosphorylates YAP1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193702", "l": "Part of the ICD migrates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202724", "l": "P-selectin binds P-selectin ligand (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173725", "l": "C9 binds C5b:C6:C7:C8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211206", "l": "Translocation of DFF to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11315", "l": "atrazine + H2O <=> chloride + H(+) + hydroxyatrazine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53933", "l": "O2 + prostaglandin I2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-prostaglandin I2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102046", "l": "3,4-dichlorobenzoate-4,5-oxygenase activity"}, {"i": "MetaCyc:RXN-10427"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870461", "l": "RABGGTA and RABGGTB bind (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61606", "l": "[DsbA protein]-disulfide + [DsbB protein]-dithiol => [DsbA protein]-dithiol + [DsbB protein]-disulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029690", "l": "Caspase-6 translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42788", "l": "cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.186", "l": "\"23S rRNA (cytidine(2498)-2'-O)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48507", "l": "D-glycero-D-manno-heptose 1,7-bisphosphate + H2O <=> D-glycero-D-manno-heptose 1-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27576", "l": "(3R)-piperidine-3-carboxylate + NH4(+) => (3R)-piperidine-3-carboxamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62089", "l": "D-glucosamine 6-phosphate + NADP(+) => 2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53483", "l": "3beta-hydroxy-5alpha-androstan-17-one + H(+) + NADPH <=> 5alpha-androstane-3beta,17beta-diol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621371", "l": "CLEC4C binds HIV and HCV glycoproteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866321", "l": "VLDL binds APOC1 and APOC4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43065", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + monacolin J carboxylate => holo-[2-methylbutanoate polyketide synthase] + lovastatin carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610723", "l": "GLI proteins bind SUFU (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047431", "l": "3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46955", "l": "2 formate + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2 CO2 + H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62253", "l": "2 hydrogencarbonate(out) + Zn(2+)(out) => 2 hydrogencarbonate(in) + Zn(2+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950778", "l": "p-Y693-STAT4 dimerizes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50552", "l": "prostaglandin C1 = prostaglandin B1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31819", "l": "(2E,6E)-farnesyl diphosphate = 5-epi-alpha-selinene + diphosphate"}, {"i": "EC:4.2.3.90", "l": "\"5-epi-alpha-selinene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49119", "l": "H(+) + NADPH + O2 + protodeoxyviolaceinate <=> deoxyviolaceinate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48921", "l": "ADP + bacteriochlorophyllide g + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate => 3,8-divinyl chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879221", "l": "PSTPIP1 binds Pyrin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19228", "l": "glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098821", "l": "BMP receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59785", "l": "H2O + NADP(+) + pseudopaline => (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11220", "l": "a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15031", "l": "D-mannose + H(+) + NADH => D-mannitol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140680", "l": "histone H3-di/monomethyl-lysine-36 demethylase activity"}, {"i": "RHEA:42032", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate"}, {"i": "EC:1.14.11.27", "l": "\"[Histone H3]-dimethyl-L-lysine(36) demethylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68615", "l": "Formation of ORC(1-6) complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787820", "l": "IL34 dimer binds CSF1R (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047570", "l": "3-oxoadipate enol-lactonase activity"}, {"i": "MetaCyc:3-OXOADIPATE-ENOL-LACTONASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63325", "l": "1,2-dihexadecanoyl-sn-glycerol + ATP => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42922", "l": "H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(1498) in 16S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24527", "l": "20-oxo-5-O-beta-D-mycaminosyltylonolide + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 5-O-beta-D-mycaminosyltylonolide + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19294", "l": "a monoacylglycerol + ATP => ADP + H(+) + monoacyl-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24679", "l": "5,6,7,8-tetrahydromethanopterin + formaldehyde => 5,10-methylenetetrahydromethanopterin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380574", "l": "Dopamine synaptic vesicle docking and priming (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.51"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28654", "l": "inosine + O2 <=> 9-riburonosylhypoxanthine + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683792", "l": "p-T68-CHEK2 autophosphorylates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62100", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56222", "l": "3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP => 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52266", "l": "gramine + 2 H(+) + 2 S-adenosyl-L-homocysteine => 3-(aminomethyl)indole + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56532", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine phosphate = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32719", "l": "L-dihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-5-(methylsulfanyl)pentanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13335", "l": "beta-D-fructose 2-phosphate + phosphate => beta-D-fructose 2,6-bisphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.64", "l": "\"4-hydroxybenzoate 1-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5626938", "l": "Beta-catenin binds SOX proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0003696", "l": "satellite DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33592", "l": "sphinganine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433454", "l": "Phosphorylation of GAB2 by SFKs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102589", "l": "cyanidin 3-O-glucoside 3'',6''-O-dimalonyltransferase activity"}, {"i": "MetaCyc:RXN-15336"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701485", "l": "Active ALK binds JAK3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10618", "l": "(2R,3S,4S)-leucocyanidin + H(+) + NADPH => (2R,3S)-catechin + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-398185", "l": "LARG binds plexin B1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1254251", "l": "ERBB4s80 binds YAP1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195275", "l": "Phosphorylation of APC component of the destruction complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23517", "l": "(R)-glycerate + ATP => (2R)-3-phosphoglycerate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22613", "l": "(3S)-citramalyl-CoA => acetyl-CoA + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11492", "l": "H(+) + O-phospho-L-threonine = (R)-1-aminopropan-2-yl phosphate + CO2"}, {"i": "EC:4.1.1.81", "l": "\"Threonine-phosphate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29344", "l": "L-aspartate(in) + succinate(out) => L-aspartate(out) + succinate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12411", "l": "L-lysine + NAD(+) <=> 2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614460", "l": "Dimerization of procollagen type VI (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429415", "l": "SYK binds to integrin alphaIIb beta3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65032", "l": "3 a quinone + protoporphyrinogen IX = 3 a quinol + protoporphyrin IX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46524", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21626", "l": "FMN + 2 H(+) + NADPH => FMNH2 + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30404", "l": "Fe(3+)(out) + L-ascorbate(in) => Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.9", "l": "\"T(4) deoxyribonuclease IV\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35841", "l": "a cardiolipin + CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805205", "l": "GPR35 binds kynurenic acid (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62597", "l": "(S)-8-oxocitronellyl enol + NAD(+) => (6E)-8-oxogeranial + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265894", "l": "BRIP1 (FANCJ) helicase functions in direct unwinding of DNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399978", "l": "Protein kinase C, alpha type phosphorylates MARCKS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74711", "l": "Phosphorylation of IRS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019909", "l": "[pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36946", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33229", "l": "4-hydroxystyrene + CO2 => (E)-4-coumarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49148", "l": "dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine = dTDP-alpha-D-forosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.324", "l": "\"dTDP-4-amino-2,3,4,6-tetradeoxy-D-glucose N,N-dimethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873921", "l": "Binding of STAT1 to p-IFNGR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15662", "l": "(E)-4-coumaroyl-CoA + an anthocyanidin 3,5-di-O-beta-D-glucoside => an anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850945", "l": "Casein kinase II phosphorylates PTEN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57905", "l": "2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + O2 => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205244", "l": "Recruitment of CBL to KIT (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53261", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 1beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44701", "l": "a 2,3-saturated acyl-CoA + FAD + H(+) => a (2E)-enoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54655", "l": "peregrinol diphosphate <=> (2E,6E,10E)-geranylgeranyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62032", "l": "a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O = a 2-acyl-sn-glycero-3-phosphoglycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44895", "l": "an N-(2-hydroxyacyl)-sphinganine + UDP-alpha-D-galactose <=> an N-(2-hydroxyacyl)-beta-D-galactosyl-sphinganine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13520", "l": "ATP + dTMP <=> ADP + dTDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64646", "l": "butyl propanoate + CoA => butan-1-ol + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29816", "l": "ATP + H2O + L-proline(out) => ADP + H(+) + L-proline(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63986", "l": "5-hydroxyuridine 5'-phosphate + ADP + H(+) => 5-hydroxyuridine + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791109", "l": "GADD45A binds PCNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21542", "l": "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate => N-(5-phospho-beta-D-ribosyl)anthranilate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10260", "l": "ATP + H2O + Mg(2+)(out) = ADP + H(+) + Mg(2+)(in) + phosphate"}, {"i": "EC:7.2.2.14", "l": "\"P-type Mg(2+) transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668904", "l": "Formation of the CTF18 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15391", "l": "3',5'-cyclic AMP + diphosphate => ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16175", "l": "(S)-norcoclaurine + H2O => (4-hydroxyphenyl)acetaldehyde + dopamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961665", "l": "PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0008946", "l": "oligonucleotidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102889", "l": "beta-elemene synthase activity"}, {"i": "MetaCyc:RXN-8432"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13151", "l": "AH2 + NADP(+) => A + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196417", "l": "Reduction of desmosterol to cholesterol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63609", "l": "apelin-17 + H2O => apelin-16 + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49077", "l": "dibenzothiophene + FMNH2 + O2 => dibenzothiophene 5-oxide + FMN + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18200", "l": "H(+) + N-cyclohexylformamide <=> cyclohexyl isocyanide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37136", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate => 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47010", "l": "[DsrC protein]-dithiol + 2 AH2 + H(+) + sulfite => [DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45209", "l": "[methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M => [Co(I) methanol-specific corrinoid protein] + H(+) + methyl-coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623341", "l": "p-S133 CREB1 dimer binds the CCND1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58046", "l": "2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + CoA => a long-chain fatty acyl-CoA + alpha,alpha-trehalose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34350", "l": "(2E)-geraniol + NAD(+) <=> (2E)-geranial + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45161", "l": "3-oxopropanoate + H(+) => acetaldehyde + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11795", "l": "H(+) + NADH + O2 + propene <=> 1,2-epoxypropane + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56884", "l": "adenosine(32) in tRNA + S-adenosyl-L-methionine = 2'-O-methyladenosine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25422", "l": "3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA + A + 2 ADP + 2 H(+) + 2 phosphate => 3-hydroxybenzoyl-CoA + AH2 + 2 ATP + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975097", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22394", "l": "(7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate => (9Z,12Z)-octadecadienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672011", "l": "p-AMPK:AMP binds the ULK complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202947", "l": "Caspase mediated cleavage of APC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986083", "l": "USP33 deubiquitinates ROBO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806392", "l": "TP53 stimulates MLH1 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33847", "l": "H2O + N-tetracosanoyl-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + tetracosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182594", "l": "Association of INK4 family proteins with CDK4/6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707690", "l": "BACH1 binds MAFK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42343", "l": "4-(gamma-L-glutamylamino)butanal + H2O + NAD(+) <=> 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41918", "l": "3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + hexadecanoyl-[ACP] + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.-", "l": "\"Transferring alkyl or aryl groups, other than methyl groups\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28051", "l": "H2O + NADP(+) => NAD(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008853", "l": "exodeoxyribonuclease III activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16764", "l": "chlorohydroquinone + O2 <=> 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371527", "l": "HSF1 trimer translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.1", "l": "\"DNA ligase (ATP)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57301", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O => a 2'-deoxyguanosine in DNA + H(+) + lactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60779", "l": "2-oxoglutarate + gibberellin A12 + O2 <=> CO2 + gibberellin A15 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57962", "l": "dimethyl sulfoxide + H2O + NAD(+) => dimethyl sulfide + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.112"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48352", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426032", "l": "DAG is metabolized by DAGL to 2-AG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63730", "l": "candesartan-2-N-beta-D-glucuronide + UDP => candesartan + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051449", "l": "thyrotropin-releasing hormone binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428750", "l": "Gq activation by TP receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202472", "l": "Translocation of TRAF6 to CBM complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48644", "l": "prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5334827", "l": "SUMO-CRABP2 binds atRA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18008", "l": "D-threitol + NADP(+) <=> D-erythrulose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938853", "l": "CDK6 binds RUNX1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22203", "l": "S-adenosyl-L-methionine + trans-aconitate <=> (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26504", "l": "2 H(+) + ternatin C5 + UDP => delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10402", "l": "2-oxoglutaramate + L-alanine => L-glutamine + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418662", "l": "Src activation following P2Y purinoceptor activation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51960", "l": "(Z)-2-methylpropanal oxime = 2-methylpropanenitrile + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18214", "l": "alpha-D-glucose 1-phosphate + CTP + H(+) => CDP-D-glucose + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32330", "l": "10-hydroxy-alpha-humulene + NAD(+) <=> H(+) + NADH + zerumbone"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102674", "l": "C4-demethylase activity"}, {"i": "MetaCyc:RXN-4181"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30123", "l": "H2O + tetradecanoyl-[ACP] = H(+) + holo-[ACP] + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57363", "l": "H2O + NADH <=> (6R)-NADHX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42001", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose => H(+) + isogloboside iGb3Cer (d18:1(4E)) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28109", "l": "galactitol 1-phosphate + NAD(+) <=> H(+) + keto-D-tagatose 6-phosphate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65663", "l": "A + calciol + H2O <=> AH2 + calcidiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012209", "l": "Estrogen-responsive KPNA2 gene transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21998", "l": "a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA => a 1-O-alkyl-2-acetyl-sn-glycerol + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6795473", "l": "PDPK1 phosphorylates SGK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202713", "l": "CD84 homodimerises (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29688", "l": "alpha-maltoheptaose + phosphate => alpha-D-glucose 1-phosphate + alpha-maltohexaose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389941", "l": "SHP-1 and SHP-2 bind pBTLA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626928", "l": "CREBBP binds FOXO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046180", "l": "KSPG is secreted from the cell (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32368", "l": "4 [Fe(III)cytochrome c] + L-galactono-1,4-lactone => 4 [Fe(II)cytochrome c] + 5 H(+) + L-dehydroascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2691214", "l": "NOTCH1 HD domain mutants bind JAG2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54509", "l": "all-trans-heptaprenyl diphosphate => beta-heptaprene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358919", "l": "MSH2:MSH3 exchanges ADP for ATP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20189", "l": "5,6-dihydrouracil + NAD(+) = H(+) + NADH + uracil"}, {"i": "RHEA:28791", "l": "5,6-dihydrothymine + NAD(+) = H(+) + NADH + thymine"}, {"i": "EC:1.3.1.1", "l": "\"Dihydrouracil dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52139", "l": "guanosine-5'-diphospho-5'-(DNA) + H2O <=> GMP + 2 H(+) + phospho-5'-(DNA)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19517", "l": "H2O + N,N-dimethylformamide = dimethylamine + formate"}, {"i": "EC:3.5.1.56", "l": "\"N,N-dimethylformamidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30907", "l": "(S)-3-methyl-2-oxopentanoate + CoA + NAD(+) = 2-methylbutanoyl-CoA + CO2 + NADH"}, {"i": "EC:1.2.1.25", "l": "\"Branched-chain alpha-keto acid dehydrogenase system\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8943279", "l": "GGT dimers hydrolyse GSH (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41018", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol <=> 1-O-hexadecyl-2-acetyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000121", "l": "glycerol-1-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15102", "l": "H(+) + meso-2,6-diaminoheptanedioate => CO2 + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54548", "l": "D-xylulose 1,5-bisphosphate + H2O = D-xylulose 5-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390909", "l": "HRH2 binds hist (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114684", "l": "Phosphorylation of Syntaxin-4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14659", "l": "D-ribulose 5-phosphate => aldehydo-D-ribose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13134", "l": "CTP + di-trans,poly-cis-dolichol => CDP + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003942", "l": "N-acetyl-gamma-glutamyl-phosphate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59011", "l": "H2O + O2 + salicylaldehyde <=> H(+) + H2O2 + salicylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804379", "l": "PRMT5 binds TTC5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-947499", "l": "Exchange of oxygen with sulfur in MoCo (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202203", "l": "Recruitment of PI3K to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21804", "l": "ATP + myo-inositol = 1D-myo-inositol 3-phosphate + ADP + H(+)"}, {"i": "EC:2.7.1.64", "l": "\"Inositol 3-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211910", "l": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696564", "l": "USP25 deubiquitinates DDX58 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60407", "l": "Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) + H2O <=> Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(2,3-dihydroxybenzoyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11405", "l": "UDP-alpha-D-glucuronate => UDP-alpha-D-galacturonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56038", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53440", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1640164", "l": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112436", "l": "Formation of Elongin complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419003", "l": "Interaction of Nectins with Afadin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987007", "l": "p-STAT1 dimerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45474", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13587", "l": "ADP + butanoyl phosphate => ATP + butanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44954", "l": "NADP(+) + octanoyl-CoA => (2E)-octenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693540", "l": "MRN activates ATM (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.18"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453346", "l": "PGYB b dimer:AMP complex <=> PGYB dimer, b form + 2 AMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690023", "l": "NUBPL binds 4Fe-4S (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31888", "l": "(S)-2,3-epoxysqualene => tirucalladienol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1253319", "l": "ERBB4s80:TAB2:NCOR1 complex translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41640", "l": "3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA = 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate"}, {"i": "EC:6.2.1.41", "l": "\"3-((3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl)propanoate--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427366", "l": "Transcription of intergenic spacer of the rRNA gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848077", "l": "PTK6 phosphorylates STAP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40349", "l": "acetyl-CoA + dodecanedioyl-CoA => 3-oxotetradecanedioyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003973", "l": "(S)-2-hydroxy-acid oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27539", "l": "ethanol + N,N-dimethyl-4-nitrosoaniline => 4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3209165", "l": "ID1 sequesters ETS2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57952", "l": "H(+) + NADH + O2 + phenol = catechol + H2O + NAD(+)"}, {"i": "EC:1.14.13.244", "l": "\"Phenol 2-monooxygenase (NADH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014652", "l": "Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46244", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (14E)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74715", "l": "Autophosphorylation of insulin receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58304", "l": "25-substituted-cholesterol + beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine = 25-substituted-cholesteryl beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10577", "l": "CTP + H(+) + N-methylethanolamine phosphate => CDP-N-methylethanolamine + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018830", "l": "gamma-hexachlorocyclohexane dehydrochlorinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662908", "l": "Dopaquinone, cysteine form CD isomers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17319", "l": "chlorophyll a + diphosphate => chlorophyllide a + H(+) + phytyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9678925", "l": "NR3C1 binds NR3C1 agonists (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36710", "l": "O-ureido-L-serine <=> O-ureido-D-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0009884", "l": "cytokinin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665761", "l": "FMNL3 binds RHOC:GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191763", "l": "snRNP:Snurportin complex formation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788628", "l": "p-Y-STATs dissociate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11826", "l": "(6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28762", "l": "beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose <=> alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852013", "l": "BTNL8 binds resting T cell surface (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63982", "l": "4-thiouridine 5'-phosphate + ADP + H(+) => 4-thiouridine + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15697", "l": "liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + licodione + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.140", "l": "\"Licodione synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0030492", "l": "hemoglobin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694790", "l": "E protein gets N-glycosylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22924", "l": "dCMP + H(+) + H2O = dUMP + NH4(+)"}, {"i": "EC:3.5.4.12", "l": "\"dCMP deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49424", "l": "ATP + validone = ADP + H(+) + validone 7-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54339", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline <=> 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39790", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809707", "l": "MTMR12 binds MTMR2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54938", "l": "decanoyl-[ACP] + NAD(+) => (2E)-decenoyl-[ACP] + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65865", "l": "5alpha-androst-1-ene-3,17-dione + A + H2O => 5alpha-androstan-1,3,17-trione + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2429719", "l": "MCPH1 sequesters condensin II (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878654", "l": "ACP6 hydrolyses MYS-LPA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12072", "l": "an (S)-2-haloacid + H2O = a (2S)-2-hydroxycarboxylate + a halide anion + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63492", "l": "H(+) + menadione + NADPH = menadiol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64941", "l": "dGDP + H2O => dGMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53377", "l": "5,6-dihydrouridine(16) in tRNA + NADP(+) => H(+) + NADPH + uridine(16) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17922", "l": "D-arabinitol + NAD(+) => D-xylulose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803527", "l": "ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34545", "l": "H(+) + N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + UDP => N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53220", "l": "16alpha,17alpha-dihydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 6beta,16alpha,17alpha-trihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008052", "l": "IL1F10(?-152) binds IL1RAPL1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36152", "l": "(E)-cinnamyl alcohol + acetyl-CoA => (E)-cinnamyl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003950", "l": "NAD+ ADP-ribosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59126", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + AMP + diphosphate => (S)-2,3-diaminopropanoate + ATP + citrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445705", "l": "Release Of ADP From Myosin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215406", "l": "PRMT5 binds WDR77 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12368", "l": "2-dehydro-D-gluconate + A = 2,5-didehydro-D-gluconate + AH2"}, {"i": "EC:1.1.99.4", "l": "\"Dehydrogluconate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939335", "l": "RNF181 polyubiquinates BCL10 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42938", "l": "2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(32) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56631", "l": "5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H2O <=> chloride + 2 H(+) + maleylacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30075", "l": "CMP + H2O = cytosine + D-ribose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64235", "l": "8 H(+) + holo-[ACP] + 8 malonyl-CoA <=> atrochrysone carboxyl-[ACP] + 8 CO2 + 8 CoA + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52908", "l": "3-dimethylallyl-4-hydroxyphenylpyruvate + O2 = 3-dimethylallyl-4-hydroxymandelate + CO2"}, {"i": "EC:1.13.11.83", "l": "\"4-hydroxy-3-prenylphenylpyruvate oxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63980", "l": "4-thiouridine + ATP = 4-thiouridine 5'-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034028", "l": "5-(carboxyamino)imidazole ribonucleotide synthase activity"}, {"i": "RHEA:19317", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate"}, {"i": "EC:6.3.4.18", "l": "\"5-(carboxyamino)imidazole ribonucleotide synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0035256", "l": "G protein-coupled glutamate receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43630", "l": "aminoacetaldehyde + CO2 + NADH => L-serine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21700", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate"}, {"i": "EC:3.1.3.77", "l": "\"Acireductone synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9669854", "l": "KIT binds type II TKIs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24398", "l": "1,3,8-trihydroxynaphthalene + H2O => scytalone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26498", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose = delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19846", "l": "nocardicin E + S-adenosyl-L-methionine => H(+) + isonocardicin A + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29362", "l": "H2O + UMP <=> phosphate + uridine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251555", "l": "Expression of AXIN1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40368", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3772430", "l": "CTNNBIP1 binds beta-catenin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57310", "l": "diphosphate + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine => CTP + H(+) + N(5)-phospho-L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205649", "l": "p62 links damaged mitochondria to LC3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865276", "l": "PDGF-AB clevage by Furin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59685", "l": "D-maltohexaose + O2 => D-maltohexaono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990362", "l": "butanol dehydrogenase activity"}, {"i": "RHEA:33199", "l": "butan-1-ol + NAD(+) = butanal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28952", "l": "H(+)(in) + L-arabinose(in) => H(+)(out) + L-arabinose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428625", "l": "Vesicular inhibitory amino acid transport (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0047485", "l": "protein N-terminus binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295599", "l": "SPRY2 translocates to the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15566", "l": "an N-acyl-L-amino acid + H2O => a carboxylate + an L-alpha-amino acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54376", "l": "(+)-copalyl diphosphate + H2O = diphosphate + nezukol"}, {"i": "EC:4.2.3.183", "l": "\"Nezukol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10241", "l": "a 2,3-saturated acyl-[ACP] + NAD(+) => a (2E)-enoyl-[ACP] + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25111", "l": "ATP + pyridoxine <=> ADP + H(+) + pyridoxine 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5228508", "l": "RANBP2 SUMOylates PML with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47280", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1008200", "l": "NFE2 binds the beta globin locus control region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687465", "l": "MRN complex binds RBBP8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190263", "l": "FGFR3b binds to FGF (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42098", "l": "AMP + diphosphate + H(+) + nebramycin 5' + phosphate => ATP + carbamoyl phosphate + H2O + tobramycin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22714", "l": "adenosylcob(III)inamide-GDP + diphosphate => adenosylcob(III)inamide phosphate + GTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10734", "l": "AMP + CO2 + diphosphate + firefly oxyluciferin + hnu => ATP + firefly D-luciferin + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-437139", "l": "ZnT6 transports zinc into the golgi apparatus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003908", "l": "methylated-DNA-[protein]-cysteine S-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64838", "l": "CoA + phenethyl acetate => 2-phenylethanol + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46210", "l": "AMP + diphosphate + eicosanoyl-CoA => ATP + CoA + eicosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65621", "l": "hexadecanoyl-CoA + sphinga-(4E,8E)-dienine => CoA + H(+) + N-hexadecanoylsphinga-(4E,8E)-dienine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27652", "l": "GDP + H(+) + UMP => GTP + uridine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11104", "l": "N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-methionine = H(+) + hercynine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102035", "l": "isobutyryl-CoA:FAD oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47609", "l": "3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18454", "l": "[(1->2)-beta-D-glucosyl](n)(in) + ATP + H2O => [(1->2)-beta-D-glucosyl](n)(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23703", "l": "5,10-methenyltetrahydrofolate + H2O <=> (6S)-10-formyltetrahydrofolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49446", "l": "(2-aminobenzoyl)acetate + CoA + H(+) => (2-aminobenzoyl)acetyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392064", "l": "G alpha (z) inhibits adenylate cyclase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66073", "l": "4-methyl-2-oxopentanoate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-leucine"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0106254", "l": "lipid sensor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52774", "l": "6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde triphosphate => 7,8-dihydroneopterin 3'-triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22943", "l": "ATP + L-arginine <=> ADP + H(+) + N(omega)-phospho-L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23171", "l": "coformycin + NADP(+) <=> 8-oxocoformycin + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018813", "l": "trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50756", "l": "NADP(+) + reduced [flavodoxin] = 2 H(+) + NADPH + oxidized [flavodoxin]"}, {"i": "EC:1.19.1.1", "l": "\"Flavodoxin--NADP(+) reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730863", "l": "Phosphorylation of CARMA1 by PKC-theta (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52208", "l": "alachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + methyl formate + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45469", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa-cis-undecaprenyl diphosphate => (Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39681", "l": "3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA => (11Z)-octadecenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879909", "l": "Activation of STAT5a/b by JAK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17288", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11254", "l": "beta-L-aspartylhydroxamate + NH4(+) => H(+) + hydroxylamine + L-asparagine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034821", "l": "citronellol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357479", "l": "p-AXL binds PI3K (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392187", "l": "Activated P2Y purinoceptor 12 binds G-protein Gi (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11792", "l": "H(+) + NADH + O2 + propene = 1,2-epoxypropane + H2O + NAD(+)"}, {"i": "EC:1.14.13.69", "l": "\"Alkene monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60957", "l": "17-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose => (9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.107", "l": "\"Peptidase Do\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218805", "l": "PKC autophosphorylates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20148", "l": "2-(3-amino-3-carboxypropyl)-L-histidine + S-adenosyl-L-methionine <=> 2-[3-carboxy-3-(methylammonio)propyl]-L-histidine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205117", "l": "p75NTR:NADE promotes caspase2/3 activation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30964", "l": "7,9,9'-tri-cis-neurosporene + a quinone => 7,7',9,9'-tetra-cis-lycopene + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6793666", "l": "MDM2 translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5082391", "l": "Trimerization of HSF1 in the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12539", "l": "H(+) + L-arogenate <=> CO2 + H2O + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53163", "l": "H2O + N-acyl-sn-glycero-3-phosphoethanolamine <=> an N-acylethanolamine + H(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66373", "l": "H2O + sn-glycerol 3-phosphate => glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45943", "l": "12-methyloctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(13-methyl-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31391", "l": "15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+) = all-trans-4,4'-diapolycopene + 4 FADH2"}, {"i": "RHEA:42800", "l": "15-cis-4,4'-diapophytoene + 3 FAD + 3 H(+) = all-trans-4,4'-diaponeurosporene + 3 FADH2"}, {"i": "EC:1.3.8.2", "l": "\"4,4'-diapophytoene desaturase (4,4'-diapolycopene-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653754", "l": "UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008705", "l": "methionine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429441", "l": "SYK activation by SRC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204485", "l": "Basigin binds CyPA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45445", "l": "H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphoethanolamine => H(+) + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-379387", "l": "COMT transfers Met to DA to form 3MT (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58483", "l": "a cytidine in mRNA + acetyl-CoA + ATP + H2O <=> ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445699", "l": "ATP Hydrolysis By Myosin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15025", "l": "S-adenosyl-L-methionine + xanthosine = 7-methylxanthosine + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.158", "l": "\"7-methylxanthosine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39409", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+) => 3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11217", "l": "a 2'-deoxyribonucleoside 5'-phosphate + ATP => a 2'-deoxyribonucleoside 5'-diphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788611", "l": "HYKK phosphorylates 5HLYS (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004568", "l": "chitinase activity"}, {"i": "REACT:R-HSA-6786421", "l": "CHIA hydrolyses chitin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678694", "l": "Heparanase 2 (HPSE2) cleaves heparan sulfate from its proteoglycan (plasma membrane) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8862380", "l": "HSD17B13 binds lipid droplets (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052904", "l": "N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53864", "l": "3alpha,7beta-dihydroxy-12-oxo-5beta-cholan-24-oate + NADP(+) = 7,12-dioxo-lithocholate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38094", "l": "delta-tocotrienol + S-adenosyl-L-methionine <=> beta-tocotrienol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50096", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52991", "l": "[deoxyhypusine synthase]-L-lysine + dehydrospermidine <=> [deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25334", "l": "H2O + L-cysteinyl-tRNA(Cys) = H(+) + L-cysteine + tRNA(Cys)"}, {"i": "EC:3.6.1.n3", "l": "\"L-cysteinyl-tRNA(Cys) hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11713", "l": "3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14488", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> 10-epi-juneol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.40"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-156699", "l": "Inactivation of Wee1 kinase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416683", "l": "SEMA3E binds to PLXND1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33730", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxyhexacosanoyl)-sphinganine <=> a 1,2-diacyl-sn-glycerol + Ins-1-P-Cer(d18:0/2-OH-26:0)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507870", "l": "Aquaporins passively transport water out of cells (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5250217", "l": "ARL2:GTP binds ARL2BP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429732", "l": "multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65306", "l": "chrodrimanin T + CO2 + succinate => 2-oxoglutarate + O2 + verruculide A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483089", "l": "PE is converted to PS by PTDSS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033520", "l": "TYSND1 cleaves TYSND1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51471", "l": "(R)-lactate + a quinone <=> a quinol + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28429", "l": "D-allulose 6-phosphate <=> keto-D-fructose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.30.1", "l": "\"Aspergillus nuclease S(1)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67150", "l": "2 H2O + L-citrulline + NADP(+) + S-nitroso-L-cysteinyl-[NO transferase protein] => L-arginine + L-cysteinyl-[NO transferase protein] + NADPH + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729300", "l": "Unknown kinase phosphorylates nucleoprotein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13139", "l": "cyclolaudenol + H(+) + S-adenosyl-L-homocysteine => cycloartenol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209823", "l": "Tyrosine is hydroxylated to dopa (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72619", "l": "eIF2:GTP is hydrolyzed, eIFs are released  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73729", "l": "Formation of SL1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-396941", "l": "Thrombin-activated PARs binds G-protein G12/13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685156", "l": "ATR phosphorylates RPA2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033885", "l": "10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850534", "l": "PDCL promotes G-protein beta 5 folding (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070748", "l": "interleukin-35 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.76"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62905", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc derivative + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54725", "l": "N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine => 3 H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190519", "l": "Internalization of gap junction plaques (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450975", "l": "isocitrate <=> citrate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14293", "l": "D-glucose + NAD(+) = D-glucono-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003851", "l": "2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852354", "l": "GTSE1 facilitates proteasome-mediated degradation of TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18960", "l": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.14"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15045", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097507", "l": "hypoxanthine DNA N-glycosylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66331", "l": "taurine(out) <=> taurine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37139", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate = 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34848", "l": "7,8-dihydromonapterin + H(+) + NADPH => 5,6,7,8-tetrahydromonapterin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11656", "l": "ATP + holo-[peptidyl-carrier protein] + L-proline = AMP + diphosphate + L-prolyl-[peptidyl-carrier protein]"}, {"i": "EC:6.2.1.53", "l": "\"L-proline--[L-prolyl-carrier protein] ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56039", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44511", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11725", "l": "[thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite => 3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60827", "l": "H2O + P(1),P(2)-bis(5'-adenosyl) diphosphate <=> 2 AMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141437", "l": "Formation of the MCC complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912367", "l": "MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404200", "l": "IGF1,2 binds IGF1R (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16096", "l": "(24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24R)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951690", "l": "Formation of RTC with integration competent viral DNA:BANF1:HMGA1:PSIP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.6", "l": "\"Aminopeptidase B\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61072", "l": "(-)-(R)-19-hydroxytabersonine + acetyl-CoA = (-)-(R)-19-O-acetyltabersonine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28187", "l": "aminoacetone + H2O + O2 => H2O2 + methylglyoxal + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672159", "l": "STAT binds to p-11Y PDGFRA extracellular domain dimers  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24517", "l": "acetyl-CoA + gentamicin C1a => CoA + H(+) + N(2')-acetylgentamicin C1a"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465924", "l": "OPN1LW binds 11cRAL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050296", "l": "stipitatonate decarboxylase activity"}, {"i": "RHEA:13885", "l": "H2O + stipitatonate = CO2 + stipitatate"}, {"i": "EC:4.1.1.60", "l": "\"Stipitatonate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39853", "l": "a 1,2-diacyl-sn-glycerol + glycerol => 2 a 1-acyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47637", "l": "H2O + L-arginine + NADP(+) => 5-guanidino-2-oxopentanoate + H(+) + NADPH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46759", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58873", "l": "24-methylidenelophenol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8870461", "l": "RABGGTA and RABGGTB bind (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66175", "l": "H(+)(out) + L-cystine(out) <=> H(+)(in) + L-cystine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170120", "l": "Translocation of Cdc25B to the cytoplasm (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202443", "l": "Oligomerization of CARMA1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2430535", "l": "MASTL phosphorylates ENSA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686578", "l": "Activated ATM phosphorylates ABL1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-171122", "l": "LDL + LDLR => LDL:LDLR complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183051", "l": "CBL ubiquitinates Sprouty (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64400", "l": "an L-amino acid tripeptide(out) + H(+)(out) = an L-amino acid tripeptide(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2545203", "l": "Deacetylation of cleaved cohesin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912393", "l": "MAML in complex with NICD1 recruits CDK8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015111", "l": "iodide transmembrane transporter activity"}, {"i": "REACT:R-HSA-209910", "l": "Iodide is taken up by thyroid epithelial cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59054", "l": "cadaverine + CO2 => D-lysine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247922", "l": "GGCT transforms gGluCys to OPRO (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49655", "l": "H(+) + NADH + O2 + protoviolaceinate <=> H2O + NAD(+) + violaceinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389756", "l": "AKT interacts and phosphorylates Cot (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875661", "l": "GGA3 associates with activated MET receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661217", "l": "MT1A binds zinc (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051108", "l": "carnitine-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63214", "l": "5-(2-oxopropylideneamino)-6-(D-ribitylamino)uracil + H2O => 5-amino-6-(D-ribitylamino)uracil + methylglyoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56490", "l": "H(+) + H2O + hederagenin + oxidized [NADPH--hemoprotein reductase] => O2 + oleanolate + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209903", "l": "Noradrenaline is converted to adrenaline (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106388", "l": "18S rRNA aminocarboxypropyltransferase activity"}, {"i": "RHEA:63296", "l": "an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3-carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66819", "l": "2 Na(+)(in) + tetrahydroxoborate(in) <=> 2 Na(+)(out) + tetrahydroxoborate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59124", "l": "(S)-2,3-diaminopropanoate + ATP + citrate = 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + AMP + diphosphate"}, {"i": "EC:6.3.2.54", "l": "\"L-2,3-diaminopropanoate--citrate ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8873929", "l": "Casein kinase II phosphorylates STARD10 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25672", "l": "H(+) + loliose + UDP => sucrose + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35693", "l": "1'-hydroxyversicolorone + H(+) + NADPH => (2S)-versicolorone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31139", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = 3-hydroxy-3-methyl-2-oxobutanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451283", "l": "kainate receptor binds glutamate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190263", "l": "FGFR3b binds to FGF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103083", "l": "methylthiobutylmalate isomerase activity"}, {"i": "MetaCyc:RXNQT-4167"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807872", "l": "Active ARF recruits coatomer (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39827", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + tetracosanoate = 2-hydroxytetracosanoate + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53230", "l": "16alpha-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202222", "l": "Phosphorylation of PKC theta (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58733", "l": "5-methyl-CTP + H2O => 5-methyl-CMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374664", "l": "Phosphorylation and activation of Ezrin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857686", "l": "FITM1, FITM2 bind TAGs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15269", "l": "L-xylo-hex-3-ulonolactone = H(+) + L-ascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692768", "l": "MAPKAPK5 phosphorylates KALRN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57701", "l": "a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433786", "l": "Phosphorylation of IRF3 by TBK1 complexed with activated TLR3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58542", "l": "H2O + 2 monodehydro-L-ascorbate radical + N-dodecanoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-dodecanoylglycine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46428", "l": "4beta-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-4beta,26-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13391", "l": "(2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein] => glutaryl-CoA + 2 H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199425", "l": "PHLPP dephosphorylates S473 in AKT (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61123", "l": "kaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 2 H2O + myricetin + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45508", "l": "[C-phycoerythrin beta-subunit]-Cys(84)-phycoerythrobilin = (2R,3E)-phycoerythrobilin + apo-[C-phycoerythrin beta-subunit]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800793", "l": "PIDD1 translocates to the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019980", "l": "interleukin-5 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3221982", "l": "BANP binds TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70596", "l": "GOT2 dimer deaminates L-Asp (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085992", "l": "SUMOylation of DAXX with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34237", "l": "2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite => 4-nitro-6-oxohepta-2,4-dienedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42007", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202466", "l": "Interaction of Bcl10 to CARMA1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63466", "l": "(2E,6E,10E)-geranylgeranyl phosphate + H(+) + UDP => (2E,6E,10E)-geranylgeraniol + UTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781001", "l": "EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37395", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52944", "l": "cholate + UDP-alpha-D-glucuronate = choloyl-24-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28336", "l": "dAMP + diphosphate + H(+) => dATP + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102880", "l": "isobazzanene synthase activity"}, {"i": "MetaCyc:RXN-8419"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43836", "l": "cholesterol + H(+) + NADPH + O2 = 26-hydroxycholesterol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27693", "l": "ATP + dGDP <=> ADP + dGTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636439", "l": "PtpA:Ub dephosphorylates p-Y133-VPS33B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797100", "l": "CCNK binds CDK13 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47417", "l": "an NDP-alpha-D-glucose + D-glucose => a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61631", "l": "5-aminopentanal <=> 1-piperideine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47078", "l": "17beta-hydroxy-5beta-androst-1-en-3-one + NADP(+) => 17beta-hydroxyandrosta-1,4-dien-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66098", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine => 3-phenylpyruvate + L-kynurenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13645", "l": "beta-D-glucose + NADP(+) = D-glucono-1,5-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36222", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.1.5", "l": "\"Hydrogen dehydrogenase (NAD(P)(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9611839", "l": "β3-agonists bind ADRB3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64943", "l": "dGDP + H2O <=> dGMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-507868", "l": "Aquaporins passively transport water into cells (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909718", "l": "Formation of p-STAT1 homodimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62362", "l": "(Z)-3-ureidoacrylate + FMN-N(5)-oxide + 2 H(+) => FMNH2 + O2 + uracil"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46101", "l": "11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => cortisol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37758", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928620", "l": "PAK1 autophosphorylates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24034", "l": "6-O-alpha-D-glucopyranosyl-D-fructose => sucrose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40958", "l": "(R)-5-phosphomevalonate + ATP <=> ADP + CO2 + isopentenyl phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015438", "l": "ABC-type teichoic acid transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29078", "l": "formate(out) + 2 H(+)(in) + ubiquinone-8 <=> CO2(out) + H(+)(out) + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53708", "l": "(2E)-decenoyl-CoA + NADP(+) = (2E,4Z)-decadienoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25401", "l": "(7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate => (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549493", "l": "Expression of PERIOD-2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35115", "l": "4-coumaroyl-CoA + H(+) + malonyl-CoA = (4-coumaroyl)acetyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209224", "l": "SLMB binds to and ubiquitinates phosphorylated CI (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28292", "l": "(5S,9S,10S)-drim-7-en-11-ol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16330", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46604", "l": "[HPr protein]-O-phospho-L-serine + H(+) + phosphate = [HPr protein]-L-serine + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58738", "l": "5-methyl-UMP + diphosphate + H(+) => H2O + TTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989766", "l": "Expression of CTGF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33069", "l": "(4R)-hydroxysphinganine + phosphate => (4R)-hydroxysphinganine 1-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005056", "l": "tiggrin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63685", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + ATP => (4R,5S)-dethiobiotin + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11544", "l": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine = H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine"}, {"i": "EC:3.5.1.26", "l": "\"N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048032", "l": "galacturonate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45440", "l": "H2O + N-eicosanoyl-sn-glycero-3-phosphoethanolamine = H(+) + N-eicosanoyl ethanolamine + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66088", "l": "L-kynurenine + oxaloacetate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0052841", "l": "inositol bisdiphosphate tetrakisphosphate diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0061778", "l": "intracellular chloride channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649735", "l": "Intrinsic nucleotide exchange on RAS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65427", "l": "AMP(in) + NAD(+)(out) <=> AMP(out) + NAD(+)(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990760", "l": "osmolarity-sensing cation channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12626", "l": "(S)-malate + 1-O-(trans-sinapoyl)-beta-D-glucose => D-glucose + sinapoyl (S)-malate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357432", "l": "AXL binds SRC-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35201", "l": "(S,S)-tartrate(in) => (S,S)-tartrate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174157", "l": "Degradation of multiubiquitinated Cyclin B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54712", "l": "N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682992", "l": "KDM4A,B bind H4K20Me2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27552", "l": "(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate => di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026907", "l": "GGT hydrolyses PCTR2 to PCTR3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417820", "l": "P2Y9 receptor can bind to LPA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9688838", "l": "RIPK3 binds STUB1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61395", "l": "ATP + N(6)-(D-psicosyl)-L-lysyl-[protein] <=> ADP + H(+) + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948757", "l": "AKT phosphorylates MKRN1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18933", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O"}, {"i": "EC:4.2.1.107", "l": "\"3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981073", "l": "Expression of Interleukin-10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201685", "l": "Beta-catenin is released from the destruction complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014342", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12992", "l": "dolichyl beta-D-mannosyl phosphate + H2O <=> D-mannose + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27580", "l": "(R)-piperazine-2-carboxylate + tert-butylamine => (R)-N-tert-butylpiperazine-2-carboxamide + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008317", "l": "gurken receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53952", "l": "4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate = 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58684", "l": "FAD + 2 H(+) + NADPH + O2 = FADH2-C4alpha-hydroperoxide + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4411383", "l": "NLK phosphorylates TCF/LEF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20429", "l": "apigenin + S-adenosyl-L-methionine = acacetin + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.75", "l": "\"Apigenin 4'-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19823", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-398184", "l": "LARG activation by G alpha 12/13 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26128", "l": "(+)-copalyl diphosphate = diphosphate + isopimara-7,15-diene"}, {"i": "EC:4.2.3.44", "l": "\"Isopimara-7,15-diene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876484", "l": "NPC2 transfers CHOL to NPC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047303", "l": "glycine-oxaloacetate transaminase activity"}, {"i": "KEGG.REACTION:R00373"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804253", "l": "MDM2 ubiquitinates JMY (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4341072", "l": "SUMOylation of RARA with SUMO2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57211", "l": "glyoxal + L-cysteinyl-[protein] <=> S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186819", "l": "SH2 domain of Src binds to the active receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139906", "l": "Activation of BAD by calcineurin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-179421", "l": "Degradation of multiubiquitinated Nek2A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44814", "l": "2-demethylmenaquinol-11 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-undecaprenyl diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61174", "l": "H(+) + myricetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP => myricetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134883", "l": "Beta-catenin enhances association of IRF3 with CBP/p300  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390593", "l": "ATP Hydrolysis By Myosin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004377", "l": "GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44259", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5228508", "l": "RANBP2 SUMOylates PML with SUMO1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190141", "l": "ALAD binds to Pb2+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20306", "l": "4-hydroxybenzaldehyde + H2O + NAD(+) => 4-hydroxybenzoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10133", "l": "ATP + benzoate + CoA => AMP + benzoyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990247", "l": "N6-methyladenosine-containing RNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029468", "l": "Conversion of PA into DAG by PAP-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161792", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102013", "l": "ATPase-coupled L-glutamate tranmembrane transporter activity"}, {"i": "MetaCyc:ABC-13-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38613", "l": "cyclic ADP-ribose + H(+) + nicotinamide => NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202472", "l": "Translocation of TRAF6 to CBM complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380574", "l": "Dopamine synaptic vesicle docking and priming (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14487", "l": "10-epi-juneol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-435244", "l": "PECAM1 is phosphorylated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080150", "l": "S-adenosyl-L-methionine:benzoic acid carboxyl methyl transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49856", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.21"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428917", "l": "G13 activation by TP receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14560", "l": "H2O + raucaffricine <=> D-glucose + vomilenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45973", "l": "3-oxochol-4-en-22-oate + H(+) + NADH + O2 => 9alpha-hydroxy-3-oxochol-4-en-22-oate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0072349", "l": "modified amino acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65017", "l": "chlorothalonil + H2O => 4-hydroxychlorothalonil + chloride + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3296233", "l": "T2Rs bind bitter-tasting compounds (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12576", "l": "(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-glucose = (5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP"}, {"i": "EC:2.4.1.66", "l": "\"Procollagen glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654515", "l": "KAL1 binds HS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102183", "l": "avenastenone reductase activity"}, {"i": "MetaCyc:RXN-11939"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63009", "l": "(6Z)-octadecenamide + H2O => (6Z)-octadecenoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53046", "l": "a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28862", "l": "Ag(+)(in) + H(+)(in) <=> Ag(+)(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56889", "l": "UDP-4-dehydro-6-deoxy-alpha-D-glucose => UDP-4-dehydro-beta-L-rhamnose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38168", "l": "hexadecan-1-ol + hexadecanoyl-CoA => CoA + hexadecanyl hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26210", "l": "L-allo-threonine => acetaldehyde + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601929", "l": "Unknown nuclease cleaves cleaved transposon RNA in 6xMeR-PIWIL2:cleaved transposon RNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27296", "l": "6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-Glu)(n) => D-glucose 6-phosphate + H(+) + oxidized coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632924", "l": "TP53 stimulates GLS2 transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42916", "l": "adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine"}, {"i": "RHEA:43332", "l": "adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.192", "l": "\"23S rRNA (adenine(2503)-C(2))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13586", "l": "ATP + butanoate => ADP + butanoyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218805", "l": "PKC autophosphorylates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41696", "l": "1-O-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36766", "l": "alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose <=> beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5681987", "l": "LC3 is cleaved by ATG4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17784", "l": "H2O + N-formyl-L-methionine <=> formate + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60714", "l": "(+)-artemisinic aldehyde + H(+) + NADH => (+)-artemisinic alcohol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53749", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose => a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60286", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605768", "l": "Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047464", "l": "heparosan-N-sulfate-glucuronate 5-epimerase activity"}, {"i": "RHEA:20197", "l": "[heparosan-N-sulfate](n) = [heparan-N-sulfate](n)"}, {"i": "EC:5.1.3.17", "l": "\"Heparosan-N-sulfate-glucuronate 5-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016162", "l": "cellulose 1,4-beta-cellobiosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-351948", "l": "Mitochondrial recruitment of Drp1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38752", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12577", "l": "(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-glucose => (5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66500", "l": "GDP-alpha-D-rhamnose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706287", "l": "Active FLT3 binds to ABL2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48355", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18119", "l": "H2O + L-dopaquinone => L-tyrosine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48587", "l": "2 H2O + 2 leukotriene A4 + O2 <=> 2 lipoxin A4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.47", "l": "\"Horrilysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36314", "l": "3,4-dihydroxybenzaldehyde + H2O + NAD(+) <=> 3,4-dihydroxybenzoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865050", "l": "Ub-Cys625-UBA6 adenylates ubiquitin in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1248002", "l": "Ligand-independent dimerization of EGFRvIII mutant (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34142", "l": "Delta(9)-tetrahydrocannabinolate + H(+) <=> CO2 + Delta(9)-tetrahydrocannabinol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102820", "l": "norbixin methyltransferase activity"}, {"i": "MetaCyc:RXN-8238"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982807", "l": "JAK2 phosphorylation of GHR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61417", "l": "(S)-8-oxocitronellyl enol => cis-trans-nepetalactol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18465", "l": "L-dopa + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)"}, {"i": "EC:1.13.11.30", "l": "\"Stizolobinate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37875", "l": "aklanonate + S-adenosyl-L-methionine = methyl aklanonate + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.288", "l": "\"Aklanonic acid methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181352", "l": "LEFTY binds NODAL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851890", "l": "MET phosphorylates SHC1-2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873946", "l": "OTUD3 deubiquitinates PTEN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33399", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate(out) = L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in)"}, {"i": "EC:2.7.1.192", "l": "\"Protein-N(pi)-phosphohistidine--N-acetylmuramate phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209944", "l": "25(OH)D binds GC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158849", "l": "Phenol can form a sulfate conjugate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18391", "l": "diphosphate + UDP-alpha-D-xylose => alpha-D-xylose 1-phosphate + H(+) + UTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004486", "l": "methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity"}, {"i": "REACT:R-HSA-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65636", "l": "sphinga-(4E,8E)-dienine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoylsphinga-(4E,8E)-dienine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950766", "l": "IL27RA dimerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806831", "l": "CYB5Rs reduce MetHb to HbA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65490", "l": "2',3',3'-c-tri-AMP + 3 diphosphate => 3 ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686013", "l": "Nsp3:nsp4 binds to nsp6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58995", "l": "(E)-cinnamaldehyde + H2O + O2 <=> (E)-cinnamate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35650", "l": "ATP + GTP <=> 3',3'-cGAMP + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37412", "l": "aklavinone + NADP(+) => aklaviketone + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199518", "l": "C3d-complexed antigen binds to complement receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034041", "l": "ABC-type sterol transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15785", "l": "2 6-iminocyclohexa-2,4-dienone + A = 2-aminophenoxazin-3-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210881", "l": "Dimerization of Tie2/Ang1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799199", "l": "COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190263", "l": "FGFR3b binds to FGF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62197", "l": "2 [Fe(III)cytochrome c] + propan-2-ol => 2 [Fe(II)cytochrome c] + acetone + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45776", "l": "(indol-3-yl)acetonitrile + 2 H2O = (indol-3-yl)acetate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.29"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35481", "l": "(S)-5'-oxoaverantin + 2 H(+) + NADH => (1'S,5'R)-5'-hydroxyaverantin + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033556", "l": "dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14869", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O = acetate + an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44547", "l": "a fatty acid(out) + ATP + H2O <=> a fatty acid(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050370", "l": "tyrosine N-monooxygenase activity"}, {"i": "RHEA:22464", "l": "L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]"}, {"i": "MetaCyc:TYROSINE-N-MONOOXYGENASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59267", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O <=> Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-dihydroxybenzoyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443439", "l": "c-Src binds Raf1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47025", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O => [DsrC protein]-S-sulfo-L-cysteine/L-cysteine + 3 AH2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58910", "l": "C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+) => 7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618392", "l": "miR-26 binds to the 3'UTR of the ARL4C mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29377", "l": "adenosine + phosphate => AMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33731", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1-acyl-sn-glycero-3-phosphocholine + a cardiolipin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17190", "l": "ATP + L-phenylalanine => diphosphate + H(+) + N-adenylyl-L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34517", "l": "N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UMP => tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043755", "l": "alpha-ribazole phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17141", "l": "glycine + oxaloacetate = glyoxylate + L-aspartate"}, {"i": "EC:2.6.1.35", "l": "\"Glycine--oxaloacetate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977071", "l": "Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36899", "l": "guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.228", "l": "\"tRNA (guanine(37)-N(1))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411383", "l": "NLK phosphorylates TCF/LEF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48224", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside nLc4Cer(d18:1(4E)) + L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33271", "l": "a triacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37555", "l": "D-kanosamine 6-phosphate + H2O = kanosamine + phosphate"}, {"i": "EC:3.1.3.92", "l": "\"Kanosamine-6-phosphate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44268", "l": "3 H(+) + hexadecanoyl-CoA + 3 malonyl-CoA = 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "55.737942431277602", "identifiers": [{"i": "GO:0016747", "l": "acyltransferase activity, transferring groups other than amino-acyl groups"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39802", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+) <=> 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46155", "l": "15-cis-phytoene + a plastoquinone <=> 15,9'-di-cis-phytofluene + a plastoquinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23659", "l": "2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate <=> 3-carboxy-cis,cis-muconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797803", "l": "PTPRD binds SLITRK1-6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19510", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) => 2 H(+) + L-erythro-biopterin + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604328", "l": "AKT1 phosphorylates NOTCH4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.32"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508513", "l": "PTK2B binds JAK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0003964", "l": "RNA-directed DNA polymerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56279", "l": "ATP + L-proline <=> 3'-L-prolyl-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54223", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene <=> all-trans-neurosporene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-377640", "l": "Autophosphorylation of SRC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62554", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H(+) + UDP => beta-D-glucosylceramide + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350578", "l": "NQO1 interaction with ODC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35178", "l": "novobiocin(in) <=> novobiocin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30321", "l": "7-methylxanthine + formaldehyde + H2O + NAD(+) => H(+) + NADH + O2 + theobromine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17493", "l": "A + glycerol = AH2 + dihydroxyacetone"}, {"i": "EC:1.1.99.22", "l": "\"Glycerol dehydrogenase (acceptor)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112703", "l": "PTPN11 is phosphorylated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64760", "l": "H2O + S-ethyl-L-cysteine = ethanethiol + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112435", "l": "Formation of Elongin BC complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53255", "l": "5alpha-cholest-7-en-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> 5alpha-cholestan-7-oxo-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59373", "l": "1-hexadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O => 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + 10-hydroxyoctadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3769397", "l": "SOST binds LRP5/6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863727", "l": "STON2 is neddylated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52331", "l": "L-arginine + O2 + reduced [flavodoxin] <=> H(+) + H2O + N(omega)-hydroxy-L-arginine + oxidized [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373734", "l": "Nephrin interacts with Podocin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392064", "l": "G alpha (z) inhibits adenylate cyclase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10888", "l": "4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H2O + NADP(+) = 4-carboxy-2-hydroxy-cis,cis-muconate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29438", "l": "enterobactin(in) + H(+)(out) <=> enterobactin(out) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37361", "l": "D-glucosamine 6-phosphate(in) + L-histidyl-[protein] => D-glucosamine(out) + N(pros)-phospho-L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19482", "l": "acetyl-CoA + succinyl-CoA => 3-oxoadipyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26022", "l": "beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + H2O <=> beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3296244", "l": "SUCNR1 binds SUCCA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008917", "l": "lipopolysaccharide N-acetylglucosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65782", "l": "3-(3-chloro-4-methoxylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + metoxuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51081", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59621", "l": "H2O + N(2)-(4-aminobutanoyl)-L-lysine => 4-aminobutanoate + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3782637", "l": "HDAC8 deacetylates histones (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70971", "l": "citrate <=> isocitrate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33042", "l": "4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin <=> 2-oxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12644", "l": "(2R)-3-phosphoglycerate + NAD(+) <=> 3-phosphooxypyruvate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60526", "l": "5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine => 5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23113", "l": "6-methylsalicylate + H(+) => 3-methylphenol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32237", "l": "AMP + H(+) + NADPH + phosphate => (6S)-NADPHX + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13991", "l": "alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose => alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34398", "l": "L-phenylalanine <=> L-beta-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62729", "l": "(+)-malbrancheamide B + bromide + FAD + 2 H(+) => (+)-malbrancheamide D + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050367", "l": "tyrosine-arginine ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30094", "l": "a ubiquinone + D-alanine + H2O <=> a ubiquinol + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14655", "l": "a nucleoside 5'-phosphate + H(+) => a nucleoside 3',5'-cyclic phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613565", "l": "PRKAA2 dissociate from p-PLINs:HSPA8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0008920", "l": "lipopolysaccharide heptosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51733", "l": "glandicoline B + S-adenosyl-L-methionine => H(+) + meleagrin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981610", "l": "Neuroglobin binds oxygen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36311", "l": "3,4-dihydroxybenzaldehyde + H2O + NAD(+) = 3,4-dihydroxybenzoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047153", "l": "deoxycytidylate 5-hydroxymethyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27979", "l": "GDP-alpha-D-mannose + H2O => alpha-D-mannose 1-phosphate + GMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31557", "l": "(3S)-3-aminobutanoyl-CoA + acetoacetate => (5S)-5-amino-3-oxohexanoate + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77094", "l": "Formation of cap binding complex (CBC) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700120", "l": "PTN and MDK bind to PTPRZ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58094", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + glycerol + H(+) => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862184", "l": "USP48 cleaves polyubiquitin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102443", "l": "L-2-hydroxycarboxylate dehydrogenase (NAD+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43770", "l": "N(5)-alkyl-L-glutaminyl-[protein] + NH4(+) => an alkylamine + L-glutaminyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102712", "l": "gibberellin A13,oxoglutarate:oxygen oxidoreductase activity"}, {"i": "MetaCyc:RXN-6542"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14826", "l": "(1R,5S)-carveol + NAD(+) => (S)-carvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "70.373142106726959", "identifiers": [{"i": "GO:0022834", "l": "ligand-gated channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46459", "l": "5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH <=> 5alpha-cholest-8-en-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964284", "l": "BTK in active Gq-BTK complex is activated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030339", "l": "fatty-acyl-ethyl-ester synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4570528", "l": "SUMOylation of XPC with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-933533", "l": "Dimerization of p-IRF7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388809", "l": "CTLA-4 binds B7-1/B7-2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809309", "l": "MTMR6 binds MTMR9 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9727349", "l": "XDH dehydrogenates xanthine to form urate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9677585", "l": "CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1067659", "l": "Assembly of hexameric IL-6 receptor (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37867", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58135", "l": "A + ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] <=> AH2 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + serpentine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35059", "l": "chloramphenicol(in) + H(+)(out) = chloramphenicol(out) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63768", "l": "2 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34257", "l": "(R)-tetraprenyl-beta-curcumene + H2O => sporulenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27656", "l": "(S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2 => 2-oxobutanoate + H(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9015111", "l": "Factor Xa inhibitors binds Xa (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12049", "l": "3-oxoadipate + succinyl-CoA => 3-oxoadipyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.145"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25538", "l": "diphosphate + ent-sandaracopimara-8(14),15-diene => ent-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57826", "l": "2-deoxy-D-ribose 5-phosphate + adenine => dAMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58718", "l": "FADH2 + H(+) + H2O + NAD(+) + rifampicin hemiaminal => FADH2-C4alpha-hydroperoxide + NADH + rifampicin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66742", "l": "ADP + H(+) + N-acetyl-L-glutamate(out) + phosphate => ATP + H2O + N-acetyl-L-glutamate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641229", "l": "TLE oligomerizes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20042", "l": "3-oxopropanoate + H2O + NADP(+) => 2 H(+) + malonate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30211", "l": "2 [Fe(III)cytochrome c] + H2O + nitrous oxide = 2 [Fe(II)cytochrome c] + 2 H(+) + 2 nitric oxide"}, {"i": "EC:1.7.2.5", "l": "\"Nitric-oxide reductase (cytochrome c)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675206", "l": "PEA15 binds MAPK monomers and dimers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41820", "l": "butanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30875", "l": "2-oxoglutarate + D-lysine = 6-amino-2-oxohexanoate + D-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37251", "l": "cysteamine S-phosphate + H2O = cysteamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42517", "l": "H2O + L-gulono-1,4-lactone => H(+) + L-gulonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40627", "l": "H2O + trihexadecanoylglycerol = 2,3-dihexadecanoyl-sn-glycerol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19952", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate <=> 7,8-dihydropteroate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29607", "l": "H2O + NAD(+) + nitrous oxide = H(+) + NADH + 2 nitric oxide"}, {"i": "RHEA:29611", "l": "H2O + NADP(+) + nitrous oxide = H(+) + NADPH + 2 nitric oxide"}, {"i": "EC:1.7.1.14", "l": "\"Nitric oxide reductase (NAD(P)(+), nitrous oxide-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38501", "l": "a 2,3-diacyl-sn-glycerol + a fatty acid + H(+) => a triacyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051991", "l": "UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16554", "l": "aldehydo-D-ribose 5-phosphate + L-lysyl-[protein] => H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24594", "l": "CDP-ethanolamine + diphosphate => CTP + H(+) + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25178", "l": "4-methyl-2-oxopentanoate + CoA + NAD(+) => 3-methylbutanoyl-CoA + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417908", "l": "P2RY1 binds ADP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23315", "l": "2 sucrose <=> 1(F)-beta-D-fructosylsucrose + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43579", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76416", "l": "Benzene is hydroxylated to phenol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851933", "l": "MET phosphorylates GAB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30237", "l": "2 H(+) + L-glutamate + NADH => H2O + L-glutamate 5-semialdehyde + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203130", "l": "OLR1 binds to oxidized LDL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045030", "l": "G protein-coupled UTP receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10968", "l": "a carboxylate + CoA + GTP = an acyl-CoA + GDP + phosphate"}, {"i": "EC:6.2.1.10", "l": "\"Acid--CoA ligase (GDP-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445084", "l": "Phosphorylation of L1 by SRC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990808", "l": "F-bar domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43888", "l": "[sulfur carrier]-H + [sulfur-carrier protein]-S-sulfanyl-L-cysteine = [sulfur carrier]-SH + [sulfur-carrier protein]-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855220", "l": "(PP)2-IP4 transports from the nucleus to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10045", "l": "cyclohexanol + NAD(+) => cyclohexanone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33356", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA => 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956676", "l": "YAP1 binds TP73 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8873794", "l": "PCTP binds PC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0042165", "l": "neurotransmitter binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10817", "l": "H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside => L-fucose + methyl beta-D-galactoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29382", "l": "dGMP + H2O <=> 2'-deoxyguanosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15755", "l": "GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate => GTP + IMP + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009558", "l": "IL34 dimer binds SDC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20395", "l": "acetyl-[citrate lyase ACP] + D-pantetheine 4'-phosphate => holo-[citrate lyase ACP] + S-acetylphosphopantotheine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784861", "l": "HSPG binds LPL dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362500", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25360", "l": "(3Z)-phycoerythrobilin + 2 oxidized 2[4Fe-4S]-[ferredoxin] => biliverdin IXalpha + 4 H(+) + 2 reduced 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9006870", "l": "IL21 receptor STAT phosphorylation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21163", "l": "acetyl-CoA + ADP + oxaloacetate + phosphate <=> ATP + citrate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013159", "l": "CDC42 GEFs activate CDC42 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54617", "l": "2-oxoglutarate + heptadecanoyl-CoA + O2 => 2-hydroxyheptadecanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004956", "l": "prostaglandin D receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203662", "l": "eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-68914", "l": "DNA polymerase alpha:primase binds at the origin (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18153", "l": "2 GTP + H(+) = diphosphate + P(1),P(4)-bis(5'-guanosyl) tetraphosphate"}, {"i": "EC:2.7.7.45", "l": "\"Guanosine-triphosphate guanylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44121", "l": "hexadecanoyl-CoA + octadecan-1-ol => CoA + octadecanyl hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31730", "l": "FADH2 + O2 + styrene <=> (2S)-2-phenyloxirane + FAD + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985950", "l": "p-Y649-STAT5A, p-STAT5B dimerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25844", "l": "(1S,5R)-carveol + NAD(+) = (R)-carvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042973", "l": "glucan endo-1,3-beta-D-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23427", "l": "alpha-D-glucosamine 1-phosphate <=> D-glucosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "73.153983691316824", "identifiers": [{"i": "GO:0008134", "l": "transcription factor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48308", "l": "2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O = (3Z)-6-oxohex-3-enoyl-CoA + formate + H(+)"}, {"i": "EC:4.1.2.44", "l": "\"2,3-epoxybenzoyl-CoA dihydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47875", "l": "ganglioside GM1 + H2O <=> ganglioside GA1 + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034864", "l": "2,4,4-trimethylpentanal dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209823", "l": "Tyrosine is hydroxylated to dopa (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75856", "l": "Abortive Initiation Before Second Transition (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37265", "l": "ADP + H(+) + L-alanyl-L-aspartate(in) + phosphate => ATP + H2O + L-alanyl-L-aspartate(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004451", "l": "isocitrate lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9627369", "l": "SEPT4 binds XIAP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24582", "l": "D-sorbitol + phosphate => D-sorbitol 6-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218804", "l": "p38 MAPK activation by VEGFR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58620", "l": "N-decanoyl-(2S)-hydroxyglycine = decanamide + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16908", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O <=> a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690023", "l": "NUBPL binds 4Fe-4S (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30704", "l": "H(+) + salicylate => CO2 + phenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373705", "l": "Caspase cleavage of DCC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36050", "l": "A + D-glyceraldehyde + H2O <=> (R)-glycerate + AH2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0016716", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen"}, {"i": "EC:1.14.18.-", "l": "\"With another compound as one donor, and incorporation of one atom of oxygen\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65340", "l": "acetyl-CoA + L-threonyl-[protein] = CoA + O-acetyl-L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981621", "l": "Neuroglobin:oxygen dissociates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786034", "l": "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14082", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate => D-glyceraldehyde 3-phosphate + indole"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417842", "l": "P2Y10 receptor can bind to LPA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868118", "l": "MAPK12 phosphorylates PTPN3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6791235", "l": "GADD45A binds AURKA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038062", "l": "protein tyrosine kinase collagen receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782943", "l": "UV-DDB ubiquitinates XPC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204798", "l": "Interaction of Tie2 and p85 of PI3K (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213236", "l": "TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664879", "l": "ATM:PEX5 binds ATM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5226979", "l": "ADD1:ADD2 binds DMTN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24289", "l": "5-formimidoyltetrahydrofolate + glycine => (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31712", "l": "beta-amyrin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 11-oxo-beta-amyrin + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200646", "l": "Cytosolic folate export across the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32061", "l": "(R)-glycerate + D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49963", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + H(+) + O2 <=> 5,10-dihydrophenazine + CO2 + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62095", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-diphosphate + H2O <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674532", "l": "AAMP gene expression is positively regulated by VEGF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15044", "l": "bis-D-fructose 2',1:2,1'-dianhydride + H2O <=> inulobiose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11501", "l": "3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O => 3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672817", "l": "Active MTORC1 binds the ULK1 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047983", "l": "homoglutathione synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625406", "l": "FOXO1,FOXO3 bind KLF4 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10091", "l": "sucrose + UDP-alpha-D-galactose <=> 6(F)-alpha-D-galactosylsucrose + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40067", "l": "2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O = 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696131", "l": "AOC1 deaminates Hist (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187828", "l": "Translocation of p21 to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16100", "l": "acetylpyruvate + H2O <=> acetate + H(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25827", "l": "H2O + O2 + spermine <=> H2O2 + N-(3-aminopropyl)-4-aminobutanal + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869568", "l": "NPM1 binds TFAP2A homodimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69140", "l": "RPA binds to the Flap (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5688786", "l": "ATXN3 binds RAD23 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168038", "l": "Collagen type XV restin release (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37613", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.98.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199839", "l": "AKT can phosphorylate RSK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14515", "l": "ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate => ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44260", "l": "2 H(+) + hexadecanoyl-CoA + 2 malonyl-CoA = 4-hydroxy-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41104", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0019798", "l": "procollagen-proline dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34038", "l": "O2 + paromamine <=> 6'-oxoparomamine + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55310", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40701", "l": "1-O-octadecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + octadecan-1-ol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016286", "l": "small conductance calcium-activated potassium channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3640862", "l": "Tankyrase binds AXIN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20556", "l": "(R)-methylmalonyl-CoA <=> (S)-methylmalonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626681", "l": "Recruitment of transition zone proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32764", "l": "(3R)-3-methyl-D-ornithine + L-lysine => (3R)-3-methyl-D-ornithyl-N(6)-L-lysine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56366", "l": "carminomycin + 2 H2O + NADP(+) => 13-dihydrocarminomycin + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202717", "l": "Heterodimerization of CEACAMs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50892", "l": "a menaquinone + 2 H(+) + hydrogen sulfide + sulfite = a menaquinol + thiosulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5607746", "l": "PKC-delta is activated (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53228", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018798", "l": "RHOV binds GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683734", "l": "Glycosylated M localizes to the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75081", "l": "Formation of AT-AC B Complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879674", "l": "CD97 binds CD55 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19897", "l": "H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide"}, {"i": "EC:1.14.13.39", "l": "\"Nitric-oxide synthase (NADPH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853921", "l": "VENTX stimulates p16-INK4A transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58260", "l": "H2O + O-(ADP-D-ribosyl)-L-tyrosyl-[protein] = ADP-D-ribose + L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430308", "l": "PARVB interacts with Alpha-actinin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59256", "l": "Fe(III)-enterobactin + H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446372", "l": "Association of  PARVA with TESK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39281", "l": "ADP + dodecanoate(in) + H(+) + phosphate => ATP + dodecanoate(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10554", "l": "2-dehydro-D-glucose + H2O2 => D-glucose + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61161", "l": "quercetin + UDP-beta-L-rhamnose => H(+) + quercitrin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49408", "l": "[(1->2)-beta-D-mannosyl](n) + phosphate = [(1->2)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate"}, {"i": "EC:2.4.1.340", "l": "\"1,2-beta-oligomannan phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18435", "l": "cyclohexanone + H2O2 + NH4(+) => cyclohexylamine + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53954", "l": "4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate => 4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10586", "l": "3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+) => 4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428888", "l": "Phosphorylation of ROBO1 by ABL kinase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15278", "l": "acetyl-CoA + L-lysyl-[alpha-tubulin] => CoA + H(+) + N(6)-acetyl-L-lysyl-[alpha-tubulin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18011", "l": "CoA + H(+) + N(6)-glutaryl-L-lysyl-[protein] => glutaryl-CoA + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102698", "l": "5-epi-aristolochene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32303", "l": "(2R)-homocitrate = (1R,2S)-homoisocitrate"}, {"i": "EC:4.2.1.114", "l": "\"Methanogen homoaconitase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41844", "l": "(3R)-hydroxyoctanoyl-[ACP] = (2E)-octenoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0015391", "l": "nucleobase:cation symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31502", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51623", "l": "CTP + formate + H(+) <=> CO2 + dCTP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28235", "l": "L-glutamate 5-semialdehyde => (S)-1-pyrroline-5-carboxylate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42136", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphinganine = a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033827", "l": "high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity"}, {"i": "MetaCyc:2.4.1.197-RXN"}, {"i": "EC:2.4.1.197", "l": "\"High-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015105", "l": "arsenite transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64699", "l": "benzyl alcohol + NAD(+) <=> benzaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31308", "l": "alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate => alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050064", "l": "luteolin 7-O-glucuronosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296477", "l": "Defective AMN does not transport GIF:Cbl (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050129", "l": "N-formylglutamate deformylase activity"}, {"i": "MetaCyc:N-FORMYLGLUTAMATE-DEFORMYLASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40945", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37267", "l": "H2O + L-alanyl-L-aspartate = L-alanine + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5655483", "l": "USP1 autocleavage (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46245", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 => (14E)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47834", "l": "ganglioside GM1 + N-acetylneuraminate => ganglioside GD1a + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0008296", "l": "3'-5'-exodeoxyribonuclease activity"}, {"i": "REACT:R-HSA-9023943", "l": "MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12259", "l": "L-arogenate + NAD(+) <=> CO2 + L-tyrosine + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.48", "l": "\"Carnitine--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047852", "l": "diferric-transferrin reductase activity"}, {"i": "RHEA:13841", "l": "[transferrin[Fe(II)2]] + H(+) + NAD(+) = [transferrin[Fe(III)2]] + NADH"}, {"i": "EC:1.16.1.2", "l": "\"Diferric-transferrin reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852716", "l": "Thrombin, ELANE cleave C5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38729", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33825", "l": "NAD(+) + tetrahydro-4-hydroxyphenylpyruvate => 3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38321", "l": "(3R,4R)-3,4-dihydroxy-3,4-dihydrobenzoate + pyruvate => chorismate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61373", "l": "4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O => 4-methylumbelliferone beta-D-glucuronate(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928657", "l": "MMP2,9 cleave EPHB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11546", "l": "H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine => H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57679", "l": "4-epi-eremophilene + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-epi-eremophilene-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20763", "l": "AH2 + linalool + O2 <=> (6E)-8-hydroxylinalool + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28233", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-costunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53041", "l": "4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate => 17beta-estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52065", "l": "13-(9Z-octadecenoyloxy)-octadecanoate + H2O => (9Z)-octadecenoate + 13-hydroxy-octadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047067", "l": "hydrogen:quinone oxidoreductase activity"}, {"i": "MetaCyc:1.12.5.1-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29191", "l": "L-aspartate + menaquinone-8 = iminosuccinate + menaquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198440", "l": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10007", "l": "benzyl isothiocyanate <=> benzyl thiocyanate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33801", "l": "H(+) + L-histidinal + NADH => L-histidinol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062144", "l": "L-propargylglycine synthase activity"}, {"i": "RHEA:59892", "l": "L-2-amino-4-chloropent-4-enoate = chloride + H(+) + L-propargylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613451", "l": "p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43779", "l": "an N-(acyl)-sphingosylphosphocholine(in) <=> an N-(acyl)-sphingosylphosphocholine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653936", "l": "Formation of Ragulator complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396009", "l": "STING binds c-di-GMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41713", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H2O => a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.9", "l": "\"NADH:ubiquinone reductase (non-electrogenic)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851890", "l": "MET phosphorylates SHC1-2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654224", "l": "Activated FGFR3 binds PLCG1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62569", "l": "H2O + S-benzyl-L-cysteinylglycine => glycine + S-benzyl-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15181", "l": "an acyl-CoA(out) + ATP + H2O = ADP + an acyl-CoA(in) + H(+) + phosphate"}, {"i": "EC:7.6.2.4", "l": "\"ABC-type fatty-acyl-CoA transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57619", "l": "dihydro-ML-236C-[compactin nonaketide synthase] + H2O <=> dihydro-ML-236C carboxylate + H(+) + holo-[compactin nonaketide synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45500", "l": "[allophycocyanin beta-subunit]-Cys(84)-phycocyanobilin = (2R,3E)-phycocyanobilin + apo-[allophycocyanin beta-subunit]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098621", "l": "phosphoseryl-selenocysteinyl-tRNA selenium transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36582", "l": "dTDP-alpha-D-fucose + NAD(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944454", "l": "mTORC1 phosphorylates MAF1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033761", "l": "mugineic-acid 3-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193656", "l": "p75NTR interacts with RIP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15291", "l": "[(1->4)-beta-D-xylan](n+1) + H(+) + UDP => [(1->4)-beta-D-xylan](n) + UDP-alpha-D-xylose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24316", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (+)-copalyl diphosphate"}, {"i": "EC:5.5.1.12", "l": "\"Copalyl diphosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19432", "l": "[beta-adrenergic receptor] + ATP <=> [beta-adrenergic receptor]-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40676", "l": "L-threonine => 2-aminobut-2-enoate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018801", "l": "glutaconyl-CoA decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654603", "l": "Activated FGFR2 binds FRS3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14338", "l": "3'-phosphoadenylyl sulfate + UDP-N-acetyl-alpha-D-galactosamine 4-sulfate => adenosine 3',5'-bisphosphate + H(+) + UDP-N-acetyl-alpha-D-galactosamine 4,6-bissulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866854", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29108", "l": "H(+) + NADH + ubiquinone-8 => NAD(+) + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50919", "l": "a carboxylate + ATP + H(+) + NADPH <=> AMP + an aldehyde + diphosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45651", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57324", "l": "acetyl-CoA + N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein] = CoA + H(+) + N-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57519", "l": "dolabradiene + O2 + reduced [NADPH--hemoprotein reductase] <=> 15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2002466", "l": "Formation of allysine by LOX (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37077", "l": "2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => [sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875816", "l": "STAT3 binds activated MET receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229132", "l": "AP4 binds APP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9619756", "l": "NR1H2 binds ABCA1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647660", "l": "GSDME (1-270) binds PIPs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36304", "l": "a fatty acyl-CoA + 2 H(+) + 2 NADPH => a long-chain primary fatty alcohol + CoA + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050750", "l": "low-density lipoprotein particle receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879221", "l": "PSTPIP1 binds Pyrin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19093", "l": "2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2"}, {"i": "EC:4.1.1.111", "l": "\"Siroheme decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446322", "l": "PARVA associates with Paxillin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56895", "l": "H(+) + NADPH + UDP-4-dehydro-beta-L-rhamnose <=> NADP(+) + UDP-beta-L-rhamnose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22877", "l": "(R)-mandelamide + H2O => (R)-mandelate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37714", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-O-(1Z)-alkenyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605736", "l": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047900", "l": "formate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72671", "l": "eIF5B:GTP is hydrolyzed and released (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19747", "l": "AH2 + L-thyroxine => 3,3',5-triiodo-L-thyronine + A + H(+) + iodide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5660665", "l": "Caspase-8 binds MALT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391377", "l": "Luteinizing hormone receptor can bind LH (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22346", "l": "(R)-rosmarinate + CoA => (2R)-3-(3,4-dihydroxyphenyl)lactate + (E)-caffeoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849906", "l": "SALM1 binds NMDA receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033821", "l": "DNA beta-glucosyltransferase activity"}, {"i": "MetaCyc:2.4.1.27-RXN"}, {"i": "EC:2.4.1.27", "l": "\"DNA beta-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39542", "l": "(2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH <=> (19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56268", "l": "CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = CMP + H(+) + N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090541", "l": "MIT domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60729", "l": "citral + H2O + NADP(+) => 3,7-dimethylocta-2,6-dienoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050249", "l": "Renilla-luciferin sulfotransferase activity"}, {"i": "MetaCyc:RENILLA-LUCIFERIN-SULFOTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16844", "l": "precorrin-2 + S-adenosyl-L-methionine <=> H(+) + precorrin-3A + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25110", "l": "ADP + H(+) + pyridoxine 5'-phosphate => ATP + pyridoxine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28964", "l": "H(+)(out) + L-proline(out) => H(+)(in) + L-proline(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008061", "l": "chitin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24845", "l": "cyclobis-(1->3)-alpha-isomaltosyl + 2 H2O => 2 isomaltose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35805", "l": "7,8-dihydroneopterin 2'-phosphate + H(+) => 7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619125", "l": "CaMKK phosphorylates CAMK4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45661", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45972", "l": "3-oxochol-4-en-22-oate + H(+) + NADH + O2 = 9alpha-hydroxy-3-oxochol-4-en-22-oate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48079", "l": "a primary alcohol + N,N-dimethyl-4-nitrosoaniline <=> 4-(hydroxylamino)-N,N-dimethylaniline + an aldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130194", "l": "ABL phosphorylates WAVEs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.192"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19818", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362522", "l": "ALDHs oxidise atRAL to atRA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-868622", "l": "Glucose is transferred from UDP-glucose onto glucose-6-phosphate (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203977", "l": "SAR1 Activation And Membrane Binding (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16138", "l": "2'-deoxymugineate + NADP(+) => 3''-deamino-3''-oxonicotianamine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.5", "l": "\"Pyridoxal 5'-phosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350869", "l": "Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-996755", "l": "ZFPM proteins bind GATA proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51751", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A <=> 4-amino-4-deoxy-beta-L-arabinopyranosyl-lipid A + di-trans,octa-cis-undecaprenyl phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062158", "l": "chloride:proton antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28096", "l": "di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate => di-trans,octa-cis-undecaprenyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40989", "l": "ethylenediaminediacetate + 2 FMN + 2 glyoxylate + 3 H(+) + 2 H2O => EDTA + 2 FMNH2 + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32745", "l": "acetate + H(+) + L,L-cystathionine => L-homocysteine + O-acetyl-L-serine"}]}
{"type": "biolink:MolecularActivity", "ic": "80.661393760018115", "identifiers": [{"i": "GO:0015301", "l": "anion:anion antiporter activity"}, {"i": "REACT:R-HSA-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102746", "l": "tetrahydrogeranylgeranyl-PP reductase activity"}, {"i": "MetaCyc:RXN-7660"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928617", "l": "EPHB2 binds KALRN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31572", "l": "1-hydroxy-2-naphthoate + 2 H(+) + NADPH + O2 => CO2 + H2O + NADP(+) + naphthalene-1,2-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59365", "l": "1-octadecanoyl-2-(9,10-epoxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O => 1-octadecanoyl-sn-glycero-3-phosphoserine + 9,10-epoxyoctadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19394", "l": "L-lysine + pyruvate => (S)-2-amino-6-oxohexanoate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52144", "l": "3-phosphonopyruvate + acetyl-CoA + H2O = (R)-2-(phosphonomethyl)malate + CoA + H(+)"}, {"i": "EC:2.3.3.19", "l": "\"2-phosphonomethylmalate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10013", "l": "(R)-6-hydroxynicotine + H2O + O2 => 6-hydroxypseudooxynicotine + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "69.756993955295187", "identifiers": [{"i": "GO:0008080", "l": "N-acetyltransferase activity"}, {"i": "REACT:R-HSA-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39738", "l": "3-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 3,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57241", "l": "glyoxal + GMP => N(2)-(1-hydroxy-2-oxoethyl)-GMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44442", "l": "a triacylglycerol + glycerol => a 1,3-diacylglycerol + a 1-acylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964274", "l": "G alpha (12) binds BTK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194678", "l": "CYP51A1 demethylates LNSOL (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016157", "l": "sucrose synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52158", "l": "(R)-mandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.54", "l": "\"Calpain-3\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55820", "l": "a 7(1)-hydroxybacteriochlorophyllide d + H2O + S-adenosyl-L-methionine = 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide d + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30276", "l": "AH2 + H2O2 => A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614271", "l": "Autocleavage of ADGRG6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44726", "l": "(2E)-fatty aldehyde + H(+) + NADPH => 2,3-saturated fatty aldehyde + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0051903", "l": "S-(hydroxymethyl)glutathione dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23373", "l": "ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322422", "l": "Beta-catenin recruits SMARCA4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033232", "l": "ABC-type D-methionine transporter activity"}, {"i": "RHEA:29779", "l": "ATP + H2O + L-methionine(out) = ADP + H(+) + L-methionine(in) + phosphate"}, {"i": "EC:7.4.2.11", "l": "\"ABC-type methionine transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17661", "l": "ATP + CoA + succinate = ADP + phosphate + succinyl-CoA"}, {"i": "EC:6.2.1.5", "l": "\"Succinate--CoA ligase (ADP-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804242", "l": "TP53 binds the complex of JMY, EP300 and TTC5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032408", "l": "MutSbeta complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9704330", "l": "Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798345", "l": "PXLP-GCAT dimer ligates CoASH to 2A-3OB to form Gly and Ac-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "60.08714621648452", "identifiers": [{"i": "GO:0004553", "l": "hydrolase activity, hydrolyzing O-glycosyl compounds"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56283", "l": "3'-L-prolyl-AMP + holo-[peptidyl-carrier protein] <=> AMP + L-prolyl-[peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443418", "l": "GP1b signaling involves c-Src (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-164832", "l": "ATPase synthesizes ATP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73806", "l": "AIR + CO2 => CAIR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70577", "l": "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47147", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2889070", "l": "SLC9B2 exchanges Na+, Li+ for H+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12997", "l": "(E)-feruloyl-CoA + galactarate = 2-O-[(E)-feruloyl]-D-galactarate + CoA"}, {"i": "EC:2.3.1.130", "l": "\"Galactarate O-hydroxycinnamoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016166", "l": "phytoene dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690196", "l": "USP8 deubiquitinates RNF128 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16298", "l": "5alpha-androstane-3beta,17beta-diol + NADP(+) => 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-976801", "l": "Complement factor I complex formation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683622", "l": "mRNA5 is translated to protein M (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48538", "l": "1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+) => 1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38377", "l": "bisanhydrobacterioruberin + 2 H2O => bacterioruberin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210881", "l": "Dimerization of Tie2/Ang1 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097177", "l": "mitochondrial ribosome binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16470", "l": "(R)-2-benzylsuccinate + succinyl-CoA => (R)-2-benzylsuccinyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2430535", "l": "MASTL phosphorylates ENSA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3134962", "l": "DHX36 binds DNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35161", "l": "(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol => (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9612509", "l": "SGK phosphorylates SRF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12399", "l": "dTDP-D-galactose + H2O + 2 NADP(+) <=> dTDP-D-galacturonate + 3 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983422", "l": "Disassembly of COPII coated vesicle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212614", "l": "Glutamine transport from astrocytes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28826", "l": "H(+)(in) + L-galactonate(in) <=> H(+)(out) + L-galactonate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3245898", "l": "TCN1 binds Cbl in the circulation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050314", "l": "sym-norspermidine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865482", "l": "KMT2A (MLL) binds RUNX1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23350", "l": "(4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2 => (R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26012", "l": "3,7-dideoxy-D-threo-hepto-2,6-diuolosonate + H(+) + NADH + NH4(+) => 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54894", "l": "[LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide => [LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847880", "l": "CYTH proteins bind ARF1:GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.31"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634418", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60518", "l": "D-tryptophan => L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-560493", "l": "Expression of Perilipin (PLIN) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12197", "l": "keto-D-fructose 6-phosphate + phosphate => acetyl phosphate + D-erythrose 4-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51447", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-leucine <=> H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57916", "l": "ATP + L-aspartyl-tRNA(Asn) = 4-phosphooxy-L-aspartyl-tRNA(Asn) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22516", "l": "ATP + taurocyamine = ADP + H(+) + N-phosphotaurocyamine"}, {"i": "EC:2.7.3.4", "l": "\"Taurocyamine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804879", "l": "MDM2 ubiquitinates TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30751", "l": "ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41095", "l": "H2O + sphing-4-enine-phosphocholine = H(+) + phosphocholine + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22575", "l": "A + H2O + N-methyl-L-glutamate <=> AH2 + formaldehyde + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047746", "l": "chlorophyllase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55548", "l": "N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66688", "l": "4-farnesyl-3,5-dihydroxy-6-methylphthalide + AH2 + 2 O2 = (4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + A + acetone + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21529", "l": "[phosphate](n) + H2O => [phosphate](n-1) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45740", "l": "2-oxoglutarate + L-ectoine + O2 = 5-hydroxyectoine + CO2 + succinate"}, {"i": "EC:1.14.11.55", "l": "\"Ectoine hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54890", "l": "AMP + diphosphate + OPC-8-CoA => ATP + CoA + OPC-8"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046790", "l": "virion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48878", "l": "L-seryl-[protein] + N-acetyl-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654515", "l": "KAL1 binds HS (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48245", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 => CMP + ganglioside GM1b + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70420", "l": "HK1,2,3,GCK phosphorylate Glc to form G6P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.1", "l": "\"ABC-type polar-amino-acid transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40501", "l": "(9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31460", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate => 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607737", "l": "BCL10 oligomerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-164832", "l": "ATPase synthesizes ATP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40888", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H2O => H(+) + octadecanoate + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692315", "l": "OX40L binds OX40 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23655", "l": "N-terminal L-glutaminyl-[peptide] <=> N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986258", "l": "SLIT2:ROBO1 binds CXCR4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.25.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43361", "l": "an N-acylsphinganine + UDP-alpha-D-glucose => an N-acyl-beta-D-glucosyl-(1<->1')-sphinganine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23957", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209738", "l": "VD3 binds GC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692755", "l": "CDK1 phosphorylates MAPK6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5082356", "l": "HSF1-mediated gene expression (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47007", "l": "H2O + O-phospho-L-threonyl-[protein] <=> L-threonyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62585", "l": "ATP + H2O + L-tyrosine(out) => ADP + H(+) + L-tyrosine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16574", "l": "2-oxoglutarate + 4-(phosphooxy)-L-threonine => (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102100", "l": "mycothiol-arsenate ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34364", "l": "H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UTP => diphosphate + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018594", "l": "MECP2 binds LBR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685838", "l": "CX3 complex binds D-loop structures (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22219", "l": "(E)-caffeate + O2 <=> 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36245", "l": "NADPH + trans-coumaryl acetate => acetate + NADP(+) + trans-anol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874979", "l": "ACBD3 binds GOLGB1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198298", "l": "AKT translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39504", "l": "(2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH => (13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27282", "l": "2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+)"}, {"i": "EC:3.5.1.102", "l": "\"2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508282", "l": "SYK is a substrate for JAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373738", "l": "Neurofascin interacts with syntenin-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29955", "l": "H(+)(in) + thymidine(in) = H(+)(out) + thymidine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59478", "l": "2 A + 2 AMP + 2 diphosphate + H(+) + N-benzoyl-L-phenylalaninol => 2 AH2 + 2 ATP + benzoate + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027625", "l": "5-HEDH dehydrogenates 7-HDPAn-3 to 7-oxo-DPAn-3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045735", "l": "nutrient reservoir activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018560", "l": "protocatechuate 3,4-dioxygenase type II activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848077", "l": "PTK6 phosphorylates STAP2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097199", "l": "cysteine-type endopeptidase activity involved in apoptotic signaling pathway"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0051748", "l": "UTP-monosaccharide-1-phosphate uridylyltransferase activity"}, {"i": "RHEA:13205", "l": "a monosaccharide 1-phosphate + H(+) + UTP = a UDP-monosaccharide + diphosphate"}, {"i": "EC:2.7.7.64", "l": "\"UTP-monosaccharide-1-phosphate uridylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467633", "l": "AGRN binds LRP4:MUSK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102152", "l": "Delta12-linoleate epoxygenase activity"}, {"i": "MetaCyc:RXN-11671"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45174", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38057", "l": "CDP + H(+) + phytyl phosphate => CTP + phytol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018758", "l": "RHOH binds effectors at the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005145", "l": "interleukin-14 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30043", "l": "fumarate + L-aspartate = iminosuccinate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12427", "l": "(3S)-3-hydroxy-L-aspartate <=> NH4(+) + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11195", "l": "an (S)-2-haloacid + H2O <=> a (2R)-2-hydroxycarboxylate + a halide anion + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63924", "l": "ATP + N(4)-acetylcytidine = ADP + H(+) + N(4)-acetylcytidine 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.45", "l": "\"2-dehydro-3-deoxygluconokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247849", "l": "WLS dissociates from retromer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66172", "l": "H(+)(out) + L-cystine(out) = H(+)(in) + L-cystine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19932", "l": "[(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665761", "l": "FMNL3 binds RHOC:GTP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45133", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019174", "l": "tetrahydrothiophene 1-oxide reductase activity"}, {"i": "MetaCyc:THTOREDUCT-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694433", "l": "MIA2 binds PREB (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070974", "l": "POU domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034940", "l": "5-oxo-4,5-dihydropyrrole-2-carboxylate amidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52769", "l": "2-(glutathion-S-yl)-2-(1H-indol-3-yl)acetonitrile + H2O => 2-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706393", "l": "RHOBTB3 binds ATP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3788061", "l": "Fibronectin degradation by ADAM8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45055", "l": "(2E)-butenoyl-CoA + (R)-carnitine <=> CoA + O-(2E)-butenoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17015", "l": "3-phosphonopyruvate => H(+) + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390673", "l": "CHRM2,4 bind acetylcholine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32152", "l": "9alpha-copalyl diphosphate => (12E)-9alpha-labda-8(17),12,14-triene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374663", "l": "DCC interaction with Ezrin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209921", "l": "Monoiodinated tyrosine can be deiodinated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50482", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37066", "l": "2-thio-N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28043", "l": "CoA + NAD(+) + pyruvate => acetyl-CoA + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53799", "l": "deoxycholoyl-CoA + ursodeoxycholate <=> deoxycholate + ursodeoxycholoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56721", "l": "2 [Fe(III)cytochrome c] + L-cysteinyl-[SoxY protein] + thiosulfate => 2 [Fe(II)cytochrome c] + 2 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64856", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + phomopsene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54187", "l": "an N-acyl-aromatic L-alpha-amino acid + H2O <=> a carboxylate + an aromatic L-alpha-amino acid"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004174", "l": "electron-transferring-flavoprotein dehydrogenase activity"}, {"i": "RHEA:24052", "l": "a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein]"}, {"i": "EC:1.5.5.1", "l": "\"Electron-transferring-flavoprotein dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875523", "l": "MET binds TNS3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31261", "l": "3-butynoate + 2 H(+) + NADH => but-3-ynal + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35290", "l": "chloramphenicol(in) <=> chloramphenicol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61283", "l": "4-aminobutanoate + H2O + O2 <=> H2O2 + NH4(+) + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75850", "l": "Addition of the third nucleotide on the nascent transcript (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50404", "l": "(2-aminobenzoyl)acetate + H(+) + S-octanoyl-L-cysteinyl-[PqsC protein] = 1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57162", "l": "(3R)-3-hydroxy-L-arginyl-[ribosomal protein eS6] + CO2 + succinate => 2-oxoglutarate + L-arginyl-[ribosomal protein eS6] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46358", "l": "18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + octadecanoate + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357445", "l": "PAK1-3 dimer disassociates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047792", "l": "cyanohydrin beta-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875013", "l": "ACSM3,ACSM6 ligate CoA to BUT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13804", "l": "3 H2O + hydrogen sulfide + 3 NADP(+) <=> 4 H(+) + 3 NADPH + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49503", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O <=> GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42021", "l": "11-dehydrocorticosterone + NAD(+) => H(+) + NADH + pregn-4-ene-3,11,20,21-tetraone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11938", "l": "4 CO2 + 4 CoA + trans-resveratrol => 4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8940100", "l": "CDK1 phosphorylates VCPIP1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-184323", "l": "Monoubiquitination of N-myristoyl GAG polyprotein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707594", "l": "Hemes bind LY96 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38417", "l": "(9Z,12Z,15Z)-octadecatrienoate + 2,3-di-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycerol + H(+) => 1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51112", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6789092", "l": "NOX2 generates superoxide anion from oxygen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17844", "l": "trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40329", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687088", "l": "PKA phosphorylates MAPKAPK5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16158", "l": "2 [Fe(III)-leghemoglobin] + NADPH => 2 [Fe(II)-leghemoglobin] + H(+) + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14228", "l": "6-hydroxyhexanoate + NAD(+) <=> 6-oxohexanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41670", "l": "chelirubine + NADPH => dihydrochelirubine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39682", "l": "(11Z)-octadecenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52492", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451819", "l": "YKI binds to HTH and TSH and activates transcription (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798044", "l": "BTG2 binds CCR4-NOT complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-354124", "l": "Phosphorylation of pPTK2 by SRC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55266", "l": "di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69173", "l": "Joining of adjacent Okazaki fragments (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848713", "l": "PTK6 binds BCAR1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170964", "l": "FRS2 binds to active TrkA receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53648", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-corvol ether A + diphosphate"}, {"i": "EC:4.2.3.171", "l": "\"(+)-corvol ether A synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17442", "l": "2-oxoglutarate + L-cysteine => 2-oxo-3-sulfanylpropanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851352", "l": "CCR8 binds CCL1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53337", "l": "5,6-dihydrouridine(20) in tRNA + NADP(+) => H(+) + NADPH + uridine(20) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849094", "l": "ARHGAP35 binds RASA1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19859", "l": "a 16-oxosteroid + H(+) + NADPH => a 16alpha-hydroxysteroid + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692408", "l": "NPR2 binds NPPC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17337", "l": "catechol + O2 = (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H(+)"}, {"i": "EC:1.13.11.2", "l": "\"Catechol 2,3-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29024", "l": "H(+)(in) + L-fucose(in) => H(+)(out) + L-fucose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22446", "l": "(E)-coniferaldehyde + H(+) + NADPH => (E)-coniferol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58912", "l": "ATP + H2O + iron(III) dicitrate(out) = ADP + H(+) + iron(III) dicitrate(in) + phosphate"}, {"i": "EC:7.2.2.18", "l": "\"ABC-type ferric citrate transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12593", "l": "a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)"}, {"i": "EC:2.7.8.5", "l": "\"CDP-diacylglycerol--glycerol-3-phosphate 1-phosphatidyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.59", "l": "\"Glucan endo-1,3-alpha-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36606", "l": "2-oxoglutarate + L-enduracididine + O2 <=> (3S)-3-hydroxy-L-enduracididine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016015", "l": "morphogen activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033284", "l": "NTRK2 promotes TIAM1 phosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39572", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75850", "l": "Addition of the third nucleotide on the nascent transcript (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27615", "l": "(2Z,6E)-farnesyl diphosphate + 10 isopentenyl diphosphate => di-trans,deca-cis-tridecaprenyl diphosphate + 10 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44171", "l": "dodecanoate + 2 H(+) + NADH <=> dodecanal + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.8", "l": "\"T(4) deoxyribonuclease II\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202129", "l": "HSP90 binds eNOS:Caveolin-1:CaM complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46738", "l": "a monoacylglycerol + phosphate => H2O + monoacyl-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102540", "l": "D-mannose 6-phosphate 1-epimerase activity"}, {"i": "MetaCyc:RXN-14815"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1011598", "l": "DOCKs bind to RhoGEFs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693319", "l": "CTRC hydrolyses PRSS1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46115", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24369", "l": "L-ornithine => L-proline + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17453", "l": "5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate"}, {"i": "EC:6.3.4.13", "l": "\"Phosphoribosylamine--glycine ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14891", "l": "(5Z,7E,9E,14Z,17Z)-icosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199050", "l": "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60364", "l": "H(+)(out) + myo-inositol(out) = H(+)(in) + myo-inositol(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30078", "l": "CMP + H2O <=> cytosine + D-ribose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.2.-", "l": "\"Amide--thiol ligases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23184", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate = (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54482", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351341", "l": "Exocytosis of Proactivator polypeptide (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49486", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26273", "l": "Co-precorrin-3 + S-adenosyl-L-methionine = Co-precorrin-4 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52201", "l": "1-aci-nitro-2-(phenyl)ethane + glutathione => (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18107", "l": "ADP + Ca(2+)(out) + H(+) + phosphate => ATP + Ca(2+)(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64267", "l": "atrochrysone carboxylate + H(+) <=> atrochrysone + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17152", "l": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] <=> an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9619376", "l": "CAMK1 binds calmodulin (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007605", "l": "BRCA1 gene expression is inhibited by E2F6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.37", "l": "\"Cis-2-enoyl-CoA reductase (NADPH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47300", "l": "(9Z)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141139", "l": "Trimerization of TRAIL:TRAIL receptor complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50028", "l": "H2O + tetradecanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + tetradecanoyl-4'-phosphopantetheine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53311", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26363", "l": "2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+) => L-tyrosine + NADPH + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033846", "l": "adenosyl-fluoride synthase activity"}, {"i": "RHEA:16661", "l": "fluoride + S-adenosyl-L-methionine = 5'-deoxy-5'-fluoroadenosine + L-methionine"}, {"i": "EC:2.5.1.63", "l": "\"Adenosyl-fluoride synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033887", "l": "chondro-4-sulfatase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103077", "l": "quercetin 3-glucoside 7-O-rhamnosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51289", "l": "(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33620", "l": "ATP + CoA + tetradecanoate => AMP + diphosphate + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25225", "l": "L-arabinitol + NAD(+) = H(+) + L-arabinose + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3209165", "l": "ID1 sequesters ETS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26438", "l": "3-hydroxypropanoate + NADP(+) = 3-oxopropanoate + H(+) + NADPH"}, {"i": "EC:1.1.1.298", "l": "\"3-hydroxypropionate dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426032", "l": "DAG is metabolized by DAGL to 2-AG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168789", "l": "GHR internalization (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32909", "l": "2 a carboxylate + 2 H(+) + sn-glycerol 3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37718", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine <=> 1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209573", "l": "p75NTR:NgR complex interacts with the axonal inhibitor LINGO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35607", "l": "acetoin + NADP(+) = diacetyl + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21689", "l": "a polyvinyl alcohol + n O2 => an oxidized polyvinyl alcohol + n H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35814", "l": "(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol <=> (-)-medicarpin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46032", "l": "H2O2 + tetradecanoate = (2S)-hydroxytetradecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32059", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + H2O = (R)-glycerate + D-glucose"}, {"i": "EC:3.2.1.208", "l": "\"Glucosylglycerate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34113", "l": "H(+) + L-aspartate 4-semialdehyde + NADPH + putrescine => carboxyspermidine + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216048", "l": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11880", "l": "(S)-6-hydroxynicotine + H2O + O2 = 6-hydroxypseudooxynicotine + H2O2"}, {"i": "EC:1.5.3.5", "l": "\"(S)-6-hydroxynicotine oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018814", "l": "RHOT1 hydrolyzes GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51352", "l": "H2O + N-(9Z-octadecenoyl)-L-serine = (9Z)-octadecenoate + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55972", "l": "acetyl-CoA + ethanol = CoA + ethyl acetate"}, {"i": "EC:2.3.1.268", "l": "\"Ethanol O-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21570", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose => beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28974", "l": "H(+)(in) + shikimate(in) <=> H(+)(out) + shikimate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013568", "l": "HES5 gene expression is stimulated by NOTCH3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25628", "l": "H2O + histamine + O2 <=> H2O2 + imidazole-4-acetaldehyde + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51188", "l": "nitric oxide + superoxide = peroxynitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55209", "l": "(4R)-hydroxysphinganine 1-phosphate => (2R)-hydroxyhexadecanal + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29276", "l": "L-isoleucine(in) + Na(+)(in) => L-isoleucine(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102522", "l": "tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity"}, {"i": "MetaCyc:RXN-14518"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39613", "l": "(3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+) => 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202375", "l": "Recruitment of ITK to SLP-76 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111956", "l": "Calmodulin activates Cam-PDE 1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25309", "l": "7,8-dihydroneopterin + phosphate <=> 7,8-dihydroneopterin 3'-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110219", "l": "Cleavage of thymine by TDG glycosylase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "75.324974028080362", "identifiers": [{"i": "GO:1901682", "l": "sulfur compound transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28171", "l": "(2R)-2-hydroxy-2-methylbutanenitrile => butan-2-one + hydrogen cyanide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34926", "l": "nitrate(in) <=> nitrate(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034857", "l": "2-(methylthio)benzothiazole monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56000", "l": "H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] = beta-D-glucose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10421", "l": "pyruvate + taurine => L-alanine + sulfoacetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64220", "l": "H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689861", "l": "Recruitment of XPA and release of CAK  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55701", "l": "an inositol phosphomannosylinositol-1-phospho-N-acyl-(4R)-4-hydroxysphinganine + H2O => an N-acyl-(4R)-4-hydroxysphinganine + H(+) + mannosyldiinositol-1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451366", "l": "Activation of p38MAPK by DSCAM (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53976", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2130194", "l": "ABL phosphorylates WAVEs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53231", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45526", "l": "(2R,3E)-phycocyanobilin + apo-[C-phycocyanin alpha-subunit] => [C-phycocyanin alpha-subunit]-Cys(84)-phycocyanobilin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37533", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44630", "l": "H(+) + L-anticapsin + NADH => L-dihydroanticapsin + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57855", "l": "a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O <=> 2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391933", "l": "EP3 receptor can bind PGE2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373075", "l": "Metabotropic glutamate receptors bind glutamate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395412", "l": "Phosphorylation of SYK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140164", "l": "Golgi transport complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49522", "l": "adenosine in mRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + N(6)-methyladenosine in mRNA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645137", "l": "Activator phosphorylates STAT5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38641", "l": "1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36183", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + CDP-choline = a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)"}, {"i": "EC:2.7.8.2", "l": "\"Diacylglycerol cholinephosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52744", "l": "cyclobis-(1->3)-alpha-isomaltosyl + H2O = alpha-isomaltosyl-(1->3)-isomaltose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58966", "l": "H(+) + H2O2 + hexanoate => H2O + hexanal + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1220612", "l": "Binding of EGF to ligand-responsive EGFR mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005158", "l": "insulin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9676160", "l": "AAMP binds NOD2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169406", "l": "ISGylation of host proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28707", "l": "Cd(2+)(in) = Cd(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56754", "l": "a Delta(14) steroid + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => a 14alpha-methyl steroid + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043961", "l": "succinyl-CoA:(R)-citramalate CoA-transferase activity"}, {"i": "MetaCyc:RXN-8966"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047447", "l": "erythro-3-hydroxyaspartate ammonia-lyase activity"}, {"i": "MetaCyc:4.3.1.20-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45716", "l": "H2O + N,N,N-trimethylglycyl-CoA = CoA + glycine betaine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56918", "l": "5alpha-androstan-3,17-dione + H(+) + NADPH => 3beta-hydroxy-5alpha-androstan-17-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623355", "l": "ESR1-dependent CCND1 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63273", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 => 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3782655", "l": "HDAC10 deacetylates histone (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003847", "l": "1-alkyl-2-acetylglycerophosphocholine esterase activity"}, {"i": "MetaCyc:3.1.1.47-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49746", "l": "CO2 + deoxyviolacein + H2O => deoxyviolaceinate + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16651", "l": "(S)-3'-hydroxy-N-methylcoclaurine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56011", "l": "4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) <=> 4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655142", "l": "RCHY1 binds POLH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47094", "l": "dipicolinate + H(+) + NADPH => (S)-2,3-dihydrodipicolinate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16006", "l": "galactarate => 5-dehydro-4-deoxy-D-glucarate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247837", "l": "WNT ligands traffic to the Golgi (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592371", "l": "Initial activation of proMMP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696958", "l": "USP44 deubiquitinates CDC20 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2230983", "l": "LRP1:Hemopexin:heme is endocytosed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168894", "l": "Accumulation of M1 at the inner leaflet of the lipid bilayer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77077", "l": "Capping complex formation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9611277", "l": "P2RY12 binds P2RY12 antagonists (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2317314", "l": "AKT binds PDPK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0005381", "l": "iron ion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37573", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30599", "l": "15-cis-phytoene + 3 A = 3 AH2 + all-trans-neurosporene"}, {"i": "EC:1.3.99.28", "l": "\"Phytoene desaturase (neurosporene-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18608", "l": "1-amino-1-deoxy-scyllo-inositol + ATP <=> 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54159", "l": "2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2 <=> [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15948", "l": "aldehydo-D-glucose 6-phosphate + L-lysyl-[protein] <=> H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60145", "l": "ATP + L-glutamate + L-glutamyl-[protein] => ADP + H(+) + L-gamma-glutamyl-L-glutamyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869694", "l": "oxPL binds CD14 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007220", "l": "E2F6:TFDP1/2 binds the E2F1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018756", "l": "RHOH binds GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2514790", "l": "Elastin degradation by MMP14 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45013", "l": "H2O + N-octadecanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59682", "l": "D-maltopentaono-1,5-lactone + H2O2 => D-maltopentaose + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098616", "l": "selenate adenylyltransferase (ATP) activity"}, {"i": "REACT:R-HSA-2408525", "l": "H2SeO4 is converted to APSe by PAPSS1,2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34338", "l": "cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 22R-hydroxycholesterol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186778", "l": "SHP2 binds to the active receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110219", "l": "Cleavage of thymine by TDG glycosylase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54923", "l": "13-cis-retinol + NADP(+) <=> 13-cis-retinal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21550", "l": "acetate + L-lysyl-[alpha-tubulin] => H2O + N(6)-acetyl-L-lysyl-[alpha-tubulin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665871", "l": "ADRM1 binds 26S proteasome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24514", "l": "3-(pyrazol-1-yl)-L-alanine + H2O => L-serine + pyrazole"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109639", "l": "Formation of the closed pre-initiation complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14192", "l": "D-tryptophan + O2 <=> N-formyl-D-kynurenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22564", "l": "a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + H(+) + NADPH"}, {"i": "EC:1.3.1.104", "l": "\"Enoyl-[acyl-carrier-protein] reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14075", "l": "4-amino-3-hydroxybutanoate + CO2 => 3-hydroxy-L-glutamate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34596", "l": "H(+) + isopentadecanoyl-CoA + L-serine => 3-dehydro-15-methylhexadecasphinganine + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664950", "l": "Phosphorylated heterodimers of ERBB2 KD mutants bind SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22699", "l": "AH2 + androst-4-ene-3,17-dione + O2 <=> A + H2O + testololactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36769", "l": "CoA + H(+) + N-(2-hydroxytetracosenoyl)-sphinganine => 2-hydroxytetracosenoyl-CoA + sphinganine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050051", "l": "leukotriene-B4 20-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051011", "l": "microtubule minus-end binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3341294", "l": "Superoxide reduces cytochrome c (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35741", "l": "4-methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone => cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446211", "l": "Flipping of dolichyl-phosphate-glucose into the ER lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34456", "l": "all-trans-beta-carotene => 9-cis-beta-carotene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362522", "l": "ALDHs oxidise atRAL to atRA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37539", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-213407", "l": "Disassociation of PLC-gamma1 from SLP-76 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139941", "l": "Binding of IP3 to IP3 receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0005287", "l": "high-affinity basic amino acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661230", "l": "MT1A binds arsenic (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56249", "l": "1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => 2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38065", "l": "1-dodecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28024", "l": "AMP + diphosphate + octanoyl-[ACP] => ATP + holo-[ACP] + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44490", "l": "3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48631", "l": "a ribonucleotide in rRNA + S-adenosyl-L-methionine <=> a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814674", "l": "Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2197697", "l": "Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54943", "l": "(3Z)-decenoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxo-(5Z)-dodecenoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193669", "l": "TRAF6 binds to p75NTR:NRIF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76456", "l": "O-atom dealkylation of dextromethorphan (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17793", "l": "H2O + L-alanyl-tRNA(Thr) = H(+) + L-alanine + tRNA(Thr)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156661", "l": "Formation of Exon Junction Complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40492", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64450", "l": "2 H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine => L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034927", "l": "pyrene 1,2-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38802", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54026", "l": "(3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + CO2 + succinate => 2-oxoglutarate + L-histidyl-[ribosomal protein uL15] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54511", "l": "all-trans-heptaprenyl diphosphate <=> beta-heptaprene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033812", "l": "3-oxoadipyl-CoA thiolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9690494", "l": "RHOB translocates to the endosome membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975097", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807872", "l": "Active ARF recruits coatomer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14466", "l": "H2O + L-histidinol phosphate => L-histidinol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46948", "l": "GTP + S-adenosyl-L-methionine = N(7)-methyl-GTP + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42902", "l": "H(+) + N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(745) in 23S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050544", "l": "arachidonic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35698", "l": "(3S)-versiconol acetate + NADP(+) <=> (2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783552", "l": "OSM binds LIFR:JAKs,OSMR:JAKs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10732", "l": "ATP + firefly D-luciferin + O2 = AMP + CO2 + diphosphate + firefly oxyluciferin + hnu"}, {"i": "EC:1.13.12.7", "l": "\"Firefly luciferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806831", "l": "CYB5Rs reduce MetHb to HbA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55998", "l": "beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] => H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9688838", "l": "RIPK3 binds STUB1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023178", "l": "PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89)) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421459", "l": "uroporphyrinogen I => coproporphyrinogen I + 4 CO2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028820", "l": "Formation of VAF (virus-activated factor) complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418451", "l": "cGMP stimulates Protein Kinase G (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381612", "l": "GLP1R binds GLP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606583", "l": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1183003", "l": "Expression of Leptin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57318", "l": "ADP + cytidine 3'-phospho-5'-diphosphoramidate + H(+) => ATP + cytidine 5'-diphosphoramidate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050328", "l": "tetrahydroberberine oxidase activity"}, {"i": "MetaCyc:TETRAHYDROBERBERINE-OXIDASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18077", "l": "L-arginyl-[dinitrogen reductase] + NAD(+) = H(+) + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide"}, {"i": "EC:2.4.2.37", "l": "\"NAD(+)--dinitrogen-reductase ADP-D-ribosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21141", "l": "ATP + inosine => ADP + H(+) + IMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41407", "l": "(R)-2-methylpyrrolidine + NADP(+) <=> 2-methyl-1-pyrroline + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2752115", "l": "SPP1 (osteopontin) binds CD44 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682388", "l": "Autophagosome maturation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36289", "l": "7-methylxanthine + formaldehyde + H2O + NADP(+) => H(+) + NADPH + O2 + theobromine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26121", "l": "2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917693", "l": "ESCRT Disassembly (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684140", "l": "ATM phosphorylates RBBP8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30106", "l": "2,5-didehydro-D-gluconate + H(+) + NADH <=> 5-dehydro-D-gluconate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086057", "l": "voltage-gated calcium channel activity involved in bundle of His cell action potential"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25745", "l": "(E)-8-(methylsulfanyl)octanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-pentahomomethionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614773", "l": "MBP gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694441", "l": "CSNK1D phosphorylates SEC23 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050291", "l": "sphingosine N-acyltransferase activity"}, {"i": "MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013435", "l": "RHOD auto-activates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419428", "l": "S1PR2-5 bind S1P (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169719", "l": "Secreted CD14 binds LPS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2471842", "l": "Collagen type XXV ectomain shedding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936979", "l": "RUNX1 and GATA1 bind the promoter of the THBS1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61394", "l": "ADP + H(+) + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] => ATP + N(6)-(D-psicosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909718", "l": "Formation of p-STAT1 homodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41355", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16659", "l": "D-ribose + hypoxanthine => H2O + inosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696183", "l": "AOC3 deaminates BZAM (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4411383", "l": "NLK phosphorylates TCF/LEF (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050004", "l": "isoflavone 7-O-glucosyltransferase activity"}, {"i": "RHEA:56344", "l": "a 7-hydroxyisoflavone + UDP-alpha-D-glucose = a 7-hydroxyisoflavone 7-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47784", "l": "cytidine(3782) in 28S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(3782) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-383190", "l": "HCO3- transport through ion channel (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15501", "l": "2 L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + L-glutamine + NADPH"}, {"i": "EC:1.4.1.13", "l": "\"Glutamate synthase (NADPH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50082", "l": "ADP + H(+) + phosphate + taurodeoxycholate(out) => ATP + H2O + taurodeoxycholate(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070737", "l": "protein-glycine ligase activity, elongating"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690023", "l": "NUBPL binds 4Fe-4S (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928620", "l": "PAK1 autophosphorylates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29396", "l": "H2O + UTP => diphosphate + H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55879", "l": "apo-[aequorin] + coelenterazine <=> apo-[aequorin]--coelenterazine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375148", "l": "Interaction of NCAM1 with Neurocan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39176", "l": "(3R)-hydroxyeicosanoyl-CoA => (2E)-eicosenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16242", "l": "an NDP-alpha-D-glucose + D-fructose => a ribonucleoside 5'-diphosphate + H(+) + sucrose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57864", "l": "indole-3-carbonyl nitrile + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxy-indole-3-carbonyl nitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.165", "l": "\"Indole-3-carbonyl nitrile 4-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14591", "l": "chrysoeriol + H(+) + S-adenosyl-L-homocysteine => luteolin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18891", "l": "alpha,alpha-trehalose 6-phosphate + H(+) + UDP => D-glucose 6-phosphate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102691", "l": "UDP-glucose:benzyladenine 7-N-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-4729"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44589", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-1D-myo-inositol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018453", "l": "2-hydroxytetrahydrofuran dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430135", "l": "p-SLP-76 binds ADAP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33309", "l": "(2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein] => (2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62817", "l": "4 monapinone E + O2 => 2 dinapinone E + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34993", "l": "L-arginine(in) + L-ornithine(out) => L-arginine(out) + L-ornithine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9619355", "l": "CaMKK autophosphorylates in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59872", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27814", "l": "acetate(in) = acetate(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034888", "l": "endosulfan monooxygenase I activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351948", "l": "Mitochondrial recruitment of Drp1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32175", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose = alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696457", "l": "BDH2 dehydrogenates 3HBA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28616", "l": "(2S)-2-methylbutanenitrile + H2O => (1Z,2S)-2-methylbutanal oxime"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15575", "l": "H(+) + melatonin + S-adenosyl-L-homocysteine => N-acetylserotonin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43895", "l": "[sulfur carrier]-H + L-cysteine <=> [sulfur carrier]-SH + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44491", "l": "3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45126", "l": "acarbose 7(IV)-phosphate + ADP + H(+) => acarbose + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814298", "l": "Late envelope proteins bind cornified envelope:CDSN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428609", "l": "Type I Na+-coupled phosphate co-transport (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708557", "l": "FBXL17 binds BACH1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5334827", "l": "SUMO-CRABP2 binds atRA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62794", "l": "2 H2O + NADP(+) + nigerone => 3 H(+) + NADPH + O2 + 2 rubrofusarin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050368", "l": "tyrosine 2,3-aminomutase activity"}, {"i": "KEGG.REACTION:R00739"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686587", "l": "ABL1 phosphorylates RAD52 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63746", "l": "UDP + zolarsartan-1-N-beta-D-glucuronide => UDP-alpha-D-glucuronate + zolasartan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58104", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.6", "l": "\"Chymopapain\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684301", "l": "mRNA1 is translated to pp1a (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24108", "l": "H2O + N-methyl-2-oxoglutaramate = 2-oxoglutarate + methylamine"}, {"i": "EC:3.5.1.36", "l": "\"N-methyl-2-oxoglutaramate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30284", "l": "(-)-trans-permethrin + H2O => (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448958", "l": "Nuclear translocation of p38 MAPK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22794", "l": "nocardicin A => isonocardicin A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13852", "l": "D-arabinose <=> D-ribulose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019179", "l": "dTDP-4-amino-4,6-dideoxy-D-glucose transaminase activity"}, {"i": "RHEA:19085", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate"}, {"i": "EC:2.6.1.33", "l": "\"dTDP-4-amino-4,6-dideoxy-D-glucose transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939204", "l": "ESTG binds ESR1:chaperone complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004456", "l": "phosphogluconate dehydratase activity"}, {"i": "RHEA:17277", "l": "6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O"}, {"i": "EC:4.2.1.12", "l": "\"Phosphogluconate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10017", "l": "H2O + O-sinapoylcholine => choline + E-sinapate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44391", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA <=> 1-heptadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990749", "l": "polynucleotide adenylyltransferase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40039", "l": "2 ATP + 2 L-glutamate + N-acetyl-L-aspartate = 2 ADP + 2 H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 phosphate"}, {"i": "EC:6.3.2.42", "l": "\"N-acetylaspartylglutamylglutamate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17205", "l": "3'-phosphoadenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-bisphosphate + H(+) + quercetin 3,4'-bissulfate"}, {"i": "EC:2.8.2.27", "l": "\"Quercetin-3-sulfate 4'-sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27948", "l": "3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+) => dopamine + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193684", "l": "p62 recruits an atypical PKC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047165", "l": "flavonol-3-O-beta-glucoside O-malonyltransferase activity"}, {"i": "RHEA:20085", "l": "a flavonol 3-O-beta-D-glucoside + malonyl-CoA = a flavonol 3-O-(6-O-malonyl-beta-D-glucoside) + CoA"}, {"i": "EC:2.3.1.116", "l": "\"Flavonol-3-O-beta-glucoside O-malonyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.2", "l": "\"Membrane alanyl aminopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23778", "l": "4-phospho-L-aspartate + ADP => ATP + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858346", "l": "AMHR2 binds AMH (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029268", "l": "Phosphorylation and activation of PLCG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2534365", "l": "Slo3 Potassium Transport (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4090281", "l": "PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-481010", "l": "Surface deployment of platelet dense granule membrane components (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186765", "l": "PLC-gamma binds to the active receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30976", "l": "15-cis-phytoene + 5 A => 5 AH2 + all-trans-3,4-didehydrolycopene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77081", "l": "Formation of the CE:GMP intermediate complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203716", "l": "eNOS:Caveolin-1 complex binds to Nostrin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433395", "l": "Dimerization of sSCF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483087", "l": "PI is exchanged with PC by PITPNB (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53525", "l": "1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32913", "l": "sn-glycerol 3-phosphocholine(in) => sn-glycerol 3-phosphocholine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11551", "l": "5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O <=> 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66585", "l": "3-oxocholestane + A + H2O => 25-hydroxy 3-oxocholestane + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211219", "l": "Translocation of caspase-3 to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51222", "l": "2,4-dinitrophenyl-S-glutathione + chloride + H(+) => 1-chloro-2,4-dinitrobenzene + glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33023", "l": "6-phospho-D-gluconate + NAD(+) = CO2 + D-ribulose 5-phosphate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10412", "l": "ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+)"}, {"i": "RHEA:32487", "l": "CDP-choline + H2O = CMP + 2 H(+) + phosphocholine"}, {"i": "EC:3.6.1.13", "l": "\"ADP-ribose diphosphatase\""}, {"i": "EC:3.6.1.53", "l": "\"Mn(2+)-dependent ADP-ribose/CDP-alcohol diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35199", "l": "(S,S)-tartrate(out) = (S,S)-tartrate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57863", "l": "(E)-6-hydroxyferuloyl-CoA <=> CoA + scopoletin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32184", "l": "cholesterol + O2 => cholest-5-en-3-one + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140696", "l": "factor V -> factor Va + factor V activation peptide (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.3.7", "l": "\"3-hydroxymethylcephem carbamoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983158", "l": "Trimming of peptides in ER (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14179", "l": "(R)-prunasin + D-glucose => (R)-amygdalin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59105", "l": "chenodeoxycholate + dolichyl beta-D-glucosyl phosphate => beta-D-glucosyl-(1->3)-O-chenodeoxycholate + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63071", "l": "acetyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 2 CO2 + 3 CoA + triacetate lactone"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017124", "l": "SH3 domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21638", "l": "4-O-(beta-D-glucosyl)-trans-4-coumarate + H(+) + UDP => (E)-4-coumarate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917700", "l": "MVB Vesicle Formation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047943", "l": "glutamate-methylamine ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.1", "l": "\"Physarum polycephalum ribonuclease\""}]}
{"type": "biolink:MolecularActivity", "ic": "78.423603998002051", "identifiers": [{"i": "GO:0005351", "l": "carbohydrate:proton symporter activity"}, {"i": "TCDB:2.A.1.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13140", "l": "cycloartenol + S-adenosyl-L-methionine <=> cyclolaudenol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21643", "l": "NADP(+) + prephenate <=> 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362427", "l": "Hh-Np binds GPC5 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047168", "l": "isocitrate O-dihydroxycinnamoyltransferase activity"}, {"i": "MetaCyc:2.3.1.126-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34125", "l": "CoA + H(+) + olivetolate => 3,5,7-trioxododecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050122", "l": "N-acylhexosamine oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205117", "l": "p75NTR:NADE promotes caspase2/3 activation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30736", "l": "1D-myo-inositol 4-phosphate + H2O => myo-inositol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856223", "l": "B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130504", "l": "Cleavage of lip22 to lip10 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5226979", "l": "ADD1:ADD2 binds DMTN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59220", "l": "(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + acetate + H(+)"}, {"i": "EC:3.7.1.25", "l": "\"2-hydroxy-6-oxohepta-2,4-dienoate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170846", "l": "TGFBR2 recruits TGFBR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6795460", "l": "SGK1 phosphorylates MDM2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50610", "l": "12-oxo-leukotriene B4 + H(+) + NADPH => leukotriene B4 + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58088", "l": "1-(7Z,10Z,13Z,16Z-docosatetraenoyl)-glycerol + H2O = (7Z,10Z,13Z,16Z)-docosatetraenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33254", "l": "2 sucrose <=> 6-kestotriose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41254", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate <=> 7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193669", "l": "TRAF6 binds to p75NTR:NRIF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1605736", "l": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187608", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940561", "l": "MMP7 cleaves OPTC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14180", "l": "(R)-amygdalin + H2O <=> (R)-prunasin + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63842", "l": "[thioredoxin]-disulfide + H2O + tert-butanol => [thioredoxin]-dithiol + tert-butyl hydroperoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950398", "l": "CANX dissociates from IL27:EBI3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23858", "l": "Hg(2+) + NADPH => H(+) + Hg + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13562", "l": "H2O + meso-2,6-diaminoheptanedioate + NADP(+) => (S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41252", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => 7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53977", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33784", "l": "1(F)-beta-D-fructosylsucrose + sucrose => 1,6-kestotetraose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41467", "l": "ent-sandaracopimara-8(14),15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-sandaracopimaradien-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093331", "l": "Ras:GTP binds p120-RasGAP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12958", "l": "an acetyl ester + H2O => acetate + an aliphatic alcohol + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0019961", "l": "interferon binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38155", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (6E,10E)-geranyllinalool + diphosphate"}, {"i": "EC:4.2.3.144", "l": "\"Geranyllinalool synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-990478", "l": "Kinesin-14 is a dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41878", "l": "(2E)-dodecenoyl-[ACP] + H2O => (3R)-hydroxydodecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106379", "l": "8-oxo-(d)RTP hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786092", "l": "IL4:IL4R:JAK2 binds IL2RG:JAK3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785607", "l": "FANCM binds FAAP24 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702589", "l": "gilteritinib-resistant FLT3 mutants don't bind gilteritinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015481", "l": "maltose transporting porin activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008834", "l": "di-trans,poly-cis-decaprenylcistransferase activity"}, {"i": "RHEA:27551", "l": "(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate"}, {"i": "EC:2.5.1.31", "l": "\"Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31897", "l": "(1E,4E,8E)-alpha-humulene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49532", "l": "4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O = ethylene glycol + H(+) + terephthalate"}, {"i": "EC:3.1.1.102", "l": "\"Mono(ethylene terephthalate) hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158860", "l": "SULT1A1 dimer sulfonates NHABP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29851", "l": "H2O + UDP-N-acetyl-alpha-D-galactosamine = 2 H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62064", "l": "2-deoxy-D-glucose 6-phosphate + NAD(+) = 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004617", "l": "phosphoglycerate dehydrogenase activity"}, {"i": "REACT:R-HSA-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58434", "l": "(E)-4-oxonon-2-enal + H(+) + NADPH => (E)-4-oxonon-2-en-1-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48560", "l": "H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30740", "l": "1D-myo-inositol 3-phosphate + H2O => myo-inositol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654167", "l": "Activated FGFR1 binds PLCG1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034832", "l": "geranial dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653754", "l": "UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63662", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 2 H(+) => (S)-8-amino-7-oxononanoate + CO2 + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161282", "l": "Elastic fibres bind associated proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985153", "l": "OASL binds DDX58 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10145", "l": "a ribonucleoside 3'-phosphate + H2O => a ribonucleoside + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797803", "l": "PTPRD binds SLITRK1-6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106257", "l": "glycerol-3-phosphate dehydrogenase [NADP+] activity"}, {"i": "RHEA:11096", "l": "NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41112", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444047", "l": "Receptor FFAR3 binds carboxylates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12853", "l": "(S)-4-hydroxymandelonitrile + UDP-alpha-D-glucose = dhurrin + H(+) + UDP"}, {"i": "EC:2.4.1.85", "l": "\"Cyanohydrin beta-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-351948", "l": "Mitochondrial recruitment of Drp1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45137", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate => 7,8-dihydroneopterin 3'-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18871", "l": "ADP + H(+) + L-xylulose 5-phosphate => ATP + L-xylulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112434", "l": "Formation of DSIF complex  (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028724", "l": "AMOT proteins bind YAP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54526", "l": "3-hydroxyhexane-2,5-dione + CO2 => acetoacetate + H(+) + methylglyoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-376851", "l": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196017", "l": "Dynamin is recruited to the gap junction plaque (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34036", "l": "O2 + paromamine => 6'-oxoparomamine + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701903", "l": "ALK-, STAT3- and MECP2-dependent STAT5A gene repression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24205", "l": "acetyl phosphate + H(+) + sulfite => phosphate + sulfoacetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873918", "l": "Transphosphorylation of JAK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40449", "l": "(2S)-pristanoyl-CoA => (2R)-pristanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63002", "l": "(11Z,14Z,17Z)-eicosatrienoate + NH4(+) => (11Z,14Z,17Z)-eicosatrienamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52622", "l": "2,2-dimethylpropanoyl-CoA => 3-methylbutanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672973", "l": "MAP2Ks phosphorylate MAPKs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050400", "l": "xylitol kinase activity"}, {"i": "MetaCyc:XYLITOL-KINASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51170", "l": "3,4-dihydroxymandelaldehyde + H2O2 + methylamine => (R)-adrenaline + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018661", "l": "orcinol 2-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41434", "l": "5-hydroxy-3-methyl-L-tyrosine + H2O => 3-methyl-L-tyrosine + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51129", "l": "A + an aliphatic amine + H2O => AH2 + an aldehyde + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028273", "l": "PGH3 spontaneously dehydrates to PGJ3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052585", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, with a quinone or similar compound as acceptor"}, {"i": "EC:1.4.5.-", "l": "\"With a quinone or similar compound as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050330", "l": "theanine hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56430", "l": "(9Z,12Z)-octadecadienoate + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42147", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoyl-(4R)-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56403", "l": "[(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44703", "l": "a 2,3-saturated acyl-CoA + FAD + H(+) <=> a (2E)-enoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "ic": "81.20444558259193", "identifiers": [{"i": "GO:0005504", "l": "fatty acid binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102771", "l": "sphingolipid very long chain fatty acid alpha-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57769", "l": "2-nitrotoluene + NADH + O2 => 3-methylcatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429101", "l": "HMIT co-transports myo-inositol with a proton (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40053", "l": "3-[(1-carboxyvinyl)-oxy]benzoate + H2O => chorismate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42090", "l": "all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46496", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(in) = N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190141", "l": "ALAD binds to Pb2+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015647", "l": "peptidoglycan transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433593", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675194", "l": "Activated MAPK phosphorylates RAF1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13939", "l": "3,4-dihydroxybenzoate + NAD(+) + sulfite => 4-sulfobenzoate + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23270", "l": "glycine + urea => guanidinoacetate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13821", "l": "2-oxoglutarate + glutarate + O2 = (S)-2-hydroxyglutarate + CO2 + succinate"}, {"i": "EC:1.14.11.64", "l": "\"Glutarate dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27864", "l": "guanosine + phosphate => 3'-GMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31729", "l": "(2S)-2-phenyloxirane + FAD + H(+) + H2O => FADH2 + O2 + styrene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18136", "l": "ATP + H(+) + sulfate <=> adenosine 5'-phosphosulfate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0046997", "l": "oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor"}, {"i": "EC:1.5.8.-", "l": "\"With a flavin as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30706", "l": "H(+) + salicylate <=> CO2 + phenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31277", "l": "(S)-methylmalonate semialdehyde + H(+) + NADH => (S)-3-hydroxy-2-methylpropanoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36182", "l": "1-O-alkyl-2-acyl-sn-glycerol + CDP-choline <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211193", "l": "Homodimerization  of DFF40 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16066", "l": "2-oxoglutarate + O2 + phytanoyl-CoA => 2-hydroxyphytanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32064", "l": "8-oxo-dGDP + H2O => 8-oxo-dGMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804762", "l": "TP53 forms homotetramers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31482", "l": "soyasapogenol A + UDP-alpha-D-glucuronate <=> H(+) + soyasapogenol A 3-O-beta-D-glucuronate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174235", "l": "Association of Emi1 with Cdc20 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375384", "l": "Bombesin-like receptors bind bombesin homologues (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30091", "l": "a ubiquinone + D-alanine + H2O = a ubiquinol + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638004", "l": "RP2 binds ARL3:GTP:UNC119B (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139905", "l": "Translocation of activated BAD protein to mitochondria (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37682", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43689", "l": "N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + pyruvate => L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0008079", "l": "translation termination factor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66499", "l": "GDP-alpha-D-rhamnose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134954", "l": "DHX9 binds DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32748", "l": "ethanolamine(in) => ethanolamine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30184", "l": "L-galactonate + NAD(+) => H(+) + keto-D-tagaturonate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682010", "l": "ATG10:ATG12 binds ATG5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2545196", "l": "FN1 dimerizes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382056", "l": "Crk binds to the active PDGF receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2197770", "l": "STAB1 (FEEL-1) binds ligands (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.3.-", "l": "\"With H(+) as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45590", "l": "a long-chain fatty acyl-[ACP] + AMP + diphosphate => a long-chain fatty acid + ATP + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26322", "l": "resorcinol + S-adenosyl-L-methionine => 3-methoxyphenol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003896", "l": "DNA primase activity"}, {"i": "EC:2.7.7.101", "l": "\"DNA primase DnaG\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50568", "l": "acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673757", "l": "Ligand-independent dimerization of cytosolic PDGFRA and PDGFRB fusion proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65577", "l": "a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + UDP-alpha-D-glucuronate => an alpha-D-glucuronosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9667965", "l": "ANKLE2 binds PP2A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21182", "l": "D-glucose + indole-3-acetyl-1D-myo-inositol => 1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626220", "l": "C2CD3 binds the mother centriole (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448673", "l": "Formation of caspase-1 p10/p20 dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32603", "l": "(6E)-8-hydroxygeraniol + NADP(+) = (6E)-8-oxogeraniol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31651", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41814", "l": "butanoyl-[ACP] + NADP(+) => (2E)-butenoyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46454", "l": "cyclo(L-leucyl-L-leucyl) + 2 H(+) + 2 tRNA(Leu) => 2 L-leucyl-tRNA(Leu)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102330", "l": "palmitoyl-[acp] elongase/decarboxylase activity"}, {"i": "MetaCyc:RXN-13258"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32865", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44052", "l": "alpha,alpha-trehalose + hexadecanoyl-CoA = 2-O-hexadecanoyl-alpha,alpha-trehalose + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19997", "l": "H2O + phosphoenolpyruvate = phosphate + pyruvate"}, {"i": "EC:3.1.3.60", "l": "\"Phosphoenolpyruvate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37389", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21349", "l": "8 H(+) + 10 malonyl-CoA => 10 CO2 + 10 CoA + 2 H2O + tetracenomycin F2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54971", "l": "hexadecanoyl phosphate + sn-glycerol 3-phosphate <=> 1-hexadecanoyl-sn-glycero-3-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034840", "l": "3-hydroxymenthone dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676593", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3149519", "l": "MMACHC decyanates CNCbl (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53245", "l": "cholesta-5,7-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => cholesta-5,7-dien-3beta,24S-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24986", "l": "(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin] => (1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102600", "l": "cytochrome P450 dependent 12,13beta-epoxy-beta-amyrin hydroxylase activity"}, {"i": "MetaCyc:RXN-15384"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25595", "l": "5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2 => 2-oxoglutarate + H(+) + isochorismate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247837", "l": "WNT ligands traffic to the Golgi (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870461", "l": "RABGGTA and RABGGTB bind (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59555", "l": "N,N',N'',N'''-tetraacetylchitotetraose + O2 <=> H2O2 + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448673", "l": "Formation of caspase-1 p10/p20 dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36035", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+) = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35103", "l": "fusidate(in) = fusidate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380240", "l": "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004817", "l": "cysteine-tRNA ligase activity"}, {"i": "REACT:R-HSA-380158", "l": "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30403", "l": "Fe(3+)(out) + L-ascorbate(in) = Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in)"}, {"i": "EC:7.2.1.3", "l": "\"Ascorbate ferrireductase (transmembrane)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666129", "l": "CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45459", "l": "H2O + N-dodecanoylethanolamine <=> dodecanoate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849900", "l": "SALMs1-3 bind each other in cis interactions (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388560", "l": "EDNRA,EDNRB bind EDNs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12642", "l": "(2R)-3-phosphoglycerate + NAD(+) => 3-phosphooxypyruvate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102735", "l": "trihydroxybenzophenone synthase activity"}, {"i": "RHEA:35143", "l": "benzoyl-CoA + 2 H(+) + 3 malonyl-CoA = 2,4,6-trihydroxybenzophenone + 3 CO2 + 4 CoA"}, {"i": "EC:2.3.1.220", "l": "\"2,4,6-trihydroxybenzophenone synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43480", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389481", "l": "Orexin 1 receptor can bind orexin-A neuropeptide (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23329", "l": "a 9-cis-epoxycarotenoid + O2 => 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34543", "l": "N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine = H(+) + N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + UDP"}, {"i": "EC:2.4.1.291", "l": "\"N-acetylgalactosamine-N,N'-diacetylbacillosaminyl-diphospho-undecaprenol 4-alpha-N-acetylgalactosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697423", "l": "Endocytosis of SARS-CoV-2 Virion (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52412", "l": "4-phospho-D-erythronate + NAD(+) = 3-dehydro-4-O-phospho-D-erythronate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14757", "l": "2 [Fe(III)cytochrome c] + L-galactono-1,4-lactone = 2 [Fe(II)cytochrome c] + 3 H(+) + L-ascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33402", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate(out) <=> L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54401", "l": "1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099130", "l": "estrogen binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53348", "l": "5,6-dihydrouridine(20a) in tRNA + NAD(+) = H(+) + NADH + uridine(20a) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65995", "l": "calciol + hnu <=> 5,6-trans-vitamin D3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62315", "l": "salicylate + UDP-alpha-D-glucose <=> H(+) + salicylate 2-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197691", "l": "WIP binds WASP,N-WASP, activating them (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202478", "l": "Interaction and oligomerization of MALT1 to Bcl10 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57008", "l": "5,5'-dehydrodivanillate + H(+) + NADH + O2 = 2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + formaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391941", "l": "BLT receptors can bind LTB4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046575", "l": "rhamnogalacturonan acetylesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22094", "l": "15,16-dihydrobiliverdin + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => (3Z)-phycoerythrobilin + oxidized 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2467775", "l": "Autocleavage of ESPL1 (Separase) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5684008", "l": "NBN binds KPNA2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655193", "l": "KIAA0101 double monoubiquitination (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54238", "l": "1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-didecanoyl-sn-glycerol + CDP-choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27381", "l": "(2R)-2,3-bisphosphoglycerate + H2O = (2R)-2-phosphoglycerate + phosphate"}, {"i": "EC:3.1.3.80", "l": "\"2,3-bisphosphoglycerate 3-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64391", "l": "4 A + sn-3-O-phytanylglycerol 1-phosphate <=> 4 AH2 + sn-3-O-(geranylgeranyl)glycerol 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60387", "l": "enterobactin + H2O <=> N-(2,3-dihydroxybenzoyl)-L-serine trimer"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864029", "l": "PTPN12 dephosphorylates EGFR at Y1148 (Y1172) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22635", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + isopentenyl diphosphate <=> all-trans-hexaprenyl diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60932", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 17-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.46", "l": "\"Pyrimidine monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018658", "l": "salicylate 1-monooxygenase activity"}, {"i": "RHEA:11004", "l": "2 H(+) + NADH + O2 + salicylate = catechol + CO2 + H2O + NAD(+)"}, {"i": "EC:1.14.13.1", "l": "\"Salicylate 1-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34482", "l": "(1R,2R,3R)-prephytoene diphosphate <=> 15-cis-phytoene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351901", "l": "Caspase-mediated cleavage of MST3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047145", "l": "demethylsterigmatocystin 6-O-methyltransferase activity"}, {"i": "MetaCyc:2.1.1.109-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018592", "l": "4-nitrocatechol 4-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047598", "l": "7-dehydrocholesterol reductase activity"}, {"i": "MetaCyc:RXN66-323"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34058", "l": "festuclavine + NAD(+) <=> 6,8-dimethyl-6,7-didehydroergoline + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202222", "l": "Phosphorylation of PKC theta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189069", "l": "sucrose + H2O => glucose + fructose (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696980", "l": "Spike trimer glycoside chains get additional branches (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674385", "l": "p-T,Y MAPKs dimerize (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186786", "l": "Autophosphorylation of PDGF beta receptors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53776", "l": "3-sulfanylpropanoate + O2 = 3-sulfinopropanoate + H(+)"}, {"i": "EC:1.13.11.91", "l": "\"3-mercaptopropionate dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17501", "l": "H2O + polyneuridine aldehyde = 16-epivellosimine + CO2 + methanol"}, {"i": "EC:3.1.1.78", "l": "\"Polyneuridine-aldehyde esterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49094", "l": "H(+) + hexadecanoate + sn-glycerol 3-phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5262606", "l": "XAV939 binds tankyrase to stabilize axin and inhibit WNT signaling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047679", "l": "arginine racemase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61822", "l": "epiandrosterone 3-beta-D-glucoside + H(+) + UDP => 3beta-hydroxy-5alpha-androstan-17-one + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23446", "l": "H(+) + NADH + pyruvate => (S)-lactate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45003", "l": "(R)-carnitine + 3-hydroxybutanoyl-CoA <=> CoA + O-3-hydroxybutanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22945", "l": "3beta-hydroxy-5beta-pregnane-20-one + NADP(+) => 5beta-pregnan-3,20-dione + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102320", "l": "1,8-cineole 2-exo-monooxygenase activity"}, {"i": "MetaCyc:RXN-13133"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418200", "l": "SRC-1 bound to ARRB2 is not activated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44848", "l": "(9Z)-tetradecenoyl-CoA + (R)-carnitine = CoA + O-(9Z)-tetradecenoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199050", "l": "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015210", "l": "uracil transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791066", "l": "Expression of HYOU1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47913", "l": "6-deoxy-6-sulfo-D-gluconate => 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65159", "l": "2-oxoglutarate + O2 + preaustinoid A2 <=> CO2 + H2O + preaustinoid A3 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35642", "l": "(4S)-4-hydroxy-2-oxoglutarate <=> glyoxylate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15727", "l": "ascopyrone M + H2O => 1,5-anhydro-D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.138"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4647593", "l": "EP400 binds CDKN1A promoter (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31853", "l": "parkeol => (S)-2,3-epoxysqualene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41487", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47366", "l": "an aliphatic alcohol + dodecanoate + H(+) => a dodecanoate ester + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416698", "l": "SEMA5A binds to PLXNB3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975160", "l": "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5632649", "l": "Hh-Npp binds GAS1 and PTCH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044748", "l": "3'-5'-exoribonuclease activity involved in mature miRNA 3'-end processing"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902557", "l": "5'-adenylyl sulfate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0140142", "l": "nucleocytoplasmic carrier activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13106", "l": "glycerol 2-phosphate + H2O => glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016844", "l": "strictosidine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9639286", "l": "RRAGC,D exchanges GTP for GDP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19519", "l": "dimethylamine + formate => H2O + N,N-dimethylformamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110360", "l": "Recruitment of POLB to the AP site (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25748", "l": "L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12974", "l": "AMP + ATP => 2 ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33961", "l": "6'''-deamino-6'''-oxoneomycin C + L-glutamate => 2-oxoglutarate + neomycin C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29791", "l": "ATP + glutathione(out) + H2O = ADP + glutathione(in) + H(+) + phosphate"}, {"i": "EC:7.4.2.10", "l": "\"ABC-type glutathione transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211950", "l": "CYP24A1 24-hydroxylates CTL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47038", "l": "pseudouridine in 5S rRNA => uridine in 5S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1474266", "l": "Formation of collagen fibrils (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692408", "l": "NPR2 binds NPPC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013143", "l": "RAC1 GEFs activate RAC1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9699578", "l": "Active FLT3 phosphorylates CDKN1B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035960", "l": "Defective CYP27A1 does not 27-hydroxylate 5β-CHOL3α,7α,24(s)-triol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48804", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199093", "l": "CXADR binds to AMICA1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32944", "l": "a 1,2-diacyl-sn-glycerol + CDP-ethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003866", "l": "3-phosphoshikimate 1-carboxyvinyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42087", "l": "9-cis-retinal + H2O + NAD(+) <=> 9-cis-retinoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10825", "l": "(S)-malate + NADP(+) => H(+) + NADPH + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55223", "l": "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374680", "l": "L1 trans-homophilic interaction (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73945", "l": "FAS-mediated dimerization of procaspase-8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5591086", "l": "SERPINA5 binds activated protein C (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036081", "l": "extracellular ammonia-gated ion channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0015278", "l": "calcium-release channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663138", "l": "p-BMAL1:p-CLOCK,NPAS2 binds CCRN4L (NOCTURNIN) gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047216", "l": "inositol 3-alpha-galactosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862300", "l": "LYZ binds bacterial peptidoglycan (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209925", "l": "DIT and MIT combine to form triiodothyronine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50774", "l": "acetaldehyde + H(+) + H2O2 + nitrite => H2O + nitroethane + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483087", "l": "PI is exchanged with PC by PITPNB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158832", "l": "The acetyl group from acetyl-CoA is transferred to the NAT2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102417", "l": "apigenin-7-O-glucoside 1,6-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-13800"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41546", "l": "8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine => 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30631", "l": "alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucuronate = beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}, {"i": "EC:2.4.1.264", "l": "\"D-man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphosphoundecaprenol 2-beta-glucuronosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61298", "l": "5-deoxy-D-ribulose 1-phosphate => 5-deoxy-alpha-D-ribose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624120", "l": "CEBPA binds CDK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23369", "l": "H(+) + phenylglyoxylate => benzaldehyde + CO2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050338", "l": "thiosulfate dehydrogenase activity"}, {"i": "RHEA:20549", "l": "2 [Fe(III)cytochrome c] + 2 thiosulfate = 2 [Fe(II)cytochrome c] + 2 H(+) + tetrathionate"}, {"i": "EC:1.8.2.2", "l": "\"Thiosulfate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39547", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA = (2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4724330", "l": "Defective ALG8 does not add glucose to the N-glycan precursor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32400", "l": "(1S,2R,4S)-neodihydrocarveol + NAD(+) => (1S,4S)-dihydrocarvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41787", "l": "asialo-GM1a ganglioside (d18:1(4E)/18:0) + CMP-N-acetyl-beta-neuraminate <=> CMP + ganglioside GM1 (d18:1(4E)/18:0) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17285", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + H(+) + UDP"}, {"i": "EC:2.4.1.336", "l": "\"Monoglucosyldiacylglycerol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372697", "l": "Crk binding to p130cas (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21051", "l": "ATP + isopropylamine + L-glutamate <=> ADP + gamma-glutamyl-isopropylamide + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55074", "l": "CO2 + propanal => 2-oxobutanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607747", "l": "TRAF6 binds MALT1 oligomers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27340", "l": "2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin] <=> 15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070819", "l": "menaquinone-dependent protoporphyrinogen oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57436", "l": "guaethol + O2 + reduced [NADH--hemoprotein reductase] = acetaldehyde + catechol + H(+) + H2O + oxidized [NADH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018594", "l": "MECP2 binds LBR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170824", "l": "glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047095", "l": "2-hydroxycyclohexanone 2-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17307", "l": "dimethylamine + L-citrulline => H2O + N(omega),N(omega)-dimethyl-L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66832", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + preasperterpenoid A"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045134", "l": "uridine-diphosphatase activity"}, {"i": "KEGG.REACTION:R00155"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014454", "l": "RHOG translocates to the ER membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52255", "l": "a bacteriochlorophyllide c + H2O + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + a bacteriochlorophyllide e + 2 H(+) + 2 L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938773", "l": "RNF144A polyubiquitinates PRKDC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008919", "l": "lipopolysaccharide glucosyltransferase I activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14042", "l": "(R)-vicianin + H2O => mandelonitrile + vicianose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50089", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173111", "l": "Disassembly of viral capsid (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33367", "l": "D-glucose(out) + N(pros)-phospho-L-histidyl-[protein] = D-glucose 6-phosphate(in) + L-histidyl-[protein]"}, {"i": "EC:2.7.1.199", "l": "\"Protein-N(pi)-phosphohistidine--D-glucose phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16726", "l": "a phosphatidylglycerol phosphate + H2O => a phosphatidylglycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35859", "l": "1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32482", "l": "2 iodide + L-tyrosine + 2 NADP(+) <=> 3,5-diiodo-L-tyrosine + H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52424", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41531", "l": "(2E)-octenoyl-[ACP] + H(+) + NADH <=> NAD(+) + octanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250486", "l": "Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168915", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19230", "l": "AMP + an aromatic aldehyde + diphosphate + NADP(+) => an aromatic carboxylate + ATP + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23139", "l": "a primary amine + S-adenosyl-L-methionine <=> a methylated primary amine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193656", "l": "p75NTR interacts with RIP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51915", "l": "(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate <=> (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59813", "l": "hexadecanoyl-CoA + N-terminal glycyl-[protein] => CoA + H(+) + N-terminal N(6)-hexadecanoylglycyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008852", "l": "exodeoxyribonuclease I activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005316", "l": "high-affinity inorganic phosphate:sodium symporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016498", "l": "neuromedin K receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46625", "l": "a D-5-monosubstituted hydantoin => a L-5-monosubstituted hydantoin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.145", "l": "\"Galactan 1,3-beta-galactosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75891", "l": "Abortive Initiation After Second Transition (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56433", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44242", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + di-(9Z)-octadecenoylglycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603784", "l": "PEX19:class I PMP binds PEX3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38194", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone <=> 17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22128", "l": "(1S,2R,4S)-borneol + NAD(+) = (1S,4S)-camphor + H(+) + NADH"}, {"i": "EC:1.1.1.227", "l": "\"(-)-borneol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8873923", "l": "STARD10 binds LPCAT1 and PC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35208", "l": "H2O + IDP => H(+) + IMP + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004822", "l": "isoleucine-tRNA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65368", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O = a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46475", "l": "4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59327", "l": "D-xylose + O2 <=> D-xylono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10109", "l": "(7S)-salutaridinol + NADP(+) => H(+) + NADPH + salutaridine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32311", "l": "L-tyrosine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.36", "l": "\"Tyrosine N-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432129", "l": "FGR binds and phosphorylates LRP8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106137", "l": "IkappaB kinase complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65211", "l": "(3S)-3-hydroxybutanoyl-CoA + H2O <=> (S)-3-hydroxybutanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985201", "l": "ABCE1 binds RNASEL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665748", "l": "FMNL2 binds RHOC:GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788867", "l": "FN3K phosphorylates ketosamines (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47793", "l": "cytidine(4447) in 28S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(4447) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59229", "l": "6-sulfo-alpha-D-quinovose => 6-sulfo-beta-D-quinovose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17249", "l": "2 Fe(2+) + 2 H2O + H2O2 = 6 H(+) + 2 iron(III) oxide-hydroxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44099", "l": "decan-1-ol + hexadecanoyl-CoA <=> CoA + decanyl hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693111", "l": "RHOF auto-activates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40777", "l": "D-alpha-phenylglycine + NH4(+) => 2-amino-2-phenylacetonitrile + H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45310", "l": "11beta-prostaglandin F2-ethanolamide + NADP(+) => H(+) + NADPH + prostaglandin D2-ethanolamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034836", "l": "6-hydroxy-2-mercaptobenzothiazole monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49687", "l": "H(+) + NADH + O2 + resorcinol <=> benzene-1,2,4-triol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.7.9"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047185", "l": "N-acetylneuraminate 4-O-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41154", "l": "1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-hydroperoxy-10E-octadecenoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61991", "l": "cytidine(72) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63615", "l": "prunetin + UDP-alpha-D-glucuronate <=> prunetin-5-O-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65607", "l": "(4R)-hydroxysphinganine + eicosanoyl-CoA <=> CoA + H(+) + N-eicosanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45056", "l": "deoxynogalonate + O2 = H(+) + H2O + nogalonate"}, {"i": "EC:1.13.12.22", "l": "\"Deoxynogalonate monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707505", "l": "Hemes bind to CLEC1B dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803719", "l": "TP53 binds ZNF385A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983152", "l": "Transfer of ubiquitin from E1 to E2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322431", "l": "XIAP binds TLE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443784", "l": "Cis-heterodimerization of L1 and Contactin-1/F3/F11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37534", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0033038", "l": "bitter taste receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.8"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905576", "l": "ganglioside GT1b binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1237129", "l": "Acireductone is created (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2509827", "l": "ITPA hydrolyses ITP to IMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18593", "l": "sphinganine 1-phosphate = hexadecanal + phosphoethanolamine"}, {"i": "RHEA:33507", "l": "sphing-4-enine 1-phosphate = (2E)-hexadecenal + phosphoethanolamine"}, {"i": "EC:4.1.2.27", "l": "\"Sphinganine-1-phosphate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42238", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61035", "l": "3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-methionine <=> 5-hydroxy-3,7,3',4'-tetramethoxyflavone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696183", "l": "AOC3 deaminates BZAM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047528", "l": "2,3-dihydroxyindole 2,3-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52203", "l": "1-aci-nitro-2-(phenyl)ethane + glutathione <=> (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38756", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51028", "l": "2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 = 7-chloroindole-3-pyruvate imine dimer + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13215", "l": "2 H(+) + NADPH + succinate => H2O + NADP(+) + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.159", "l": "\"Theobromine synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0036440", "l": "citrate synthase activity"}, {"i": "RHEA:16845", "l": "acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)"}, {"i": "EC:2.3.3.3", "l": "\"Citrate (Re)-synthase\""}, {"i": "KEGG.REACTION:R00351"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204871", "l": "Interaction of Tie2 and Grb2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62107", "l": "(9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66752", "l": "(2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(in) + ATP + H2O = (2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22947", "l": "3beta-hydroxy-5beta-pregnane-20-one + NADP(+) <=> 5beta-pregnan-3,20-dione + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203774", "l": "Interaction of Csk with PAG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33649", "l": "(9Z)-hexadecenoyl-CoA + AMP + diphosphate => (9Z)-hexadecenoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-435244", "l": "PECAM1 is phosphorylated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38545", "l": "(2-aminobenzoyl)acetyl-CoA + CO2 + L-cysteinyl-[PqsD protein] => H(+) + malonyl-CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61948", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl-[protein] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390598", "l": "Myosin Binds ATP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.37", "l": "\"Acyl-CoA 5-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27383", "l": "(2R)-2-phosphoglycerate + phosphate => (2R)-2,3-bisphosphoglycerate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57308", "l": "CTP + H(+) + N(5)-phospho-L-glutamine = diphosphate + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine"}, {"i": "EC:2.7.7.103", "l": "\"L-glutamine-phosphate cytidylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875374", "l": "MET binds LRIG1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5667107", "l": "SIAH1, SIAH2 ubiquitinate SNCAIP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035651", "l": "AP-3 adaptor complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879907", "l": "Tyrosine kinases phosphorylate the receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62563", "l": "(4R)-limonene + A + H2O <=> (4R)-perillyl alcohol + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60077", "l": "4beta-hydroxymethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2 => 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59352", "l": "beta-lactose + O2 = H2O2 + lactobiono-1,5-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617896", "l": "Retinoic acid activates HOXD4 chromatin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66871", "l": "3 O2 + quiannulatene + 3 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + quiannulatate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168947", "l": "Ligand binds to TLR10 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34680", "l": "ATP + methylphosphonate => adenine + alpha-D-ribose 1-methylphosphonate 5-triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53714", "l": "beta-hematin => 2 Fe(III)-heme b"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008686", "l": "3,4-dihydroxy-2-butanone-4-phosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60417", "l": "diglucosyl-enterobactin + H2O => H(+) + N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40192", "l": "(3R)-hydroxyoctanoyl-CoA + NAD(+) => 3-oxooctanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047080", "l": "deoxyuridine 2'-dioxygenase activity"}, {"i": "RHEA:21076", "l": "2'-deoxyuridine + 2-oxoglutarate + O2 = CO2 + succinate + uridine"}, {"i": "EC:1.14.11.3", "l": "\"Pyrimidine-deoxynucleoside 2'-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40787", "l": "H2O + tetracosanoyl-CoA = CoA + H(+) + tetracosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63513", "l": "biphenyl-2,2'-diol + H(+) + NADH + O2 => biphenyl-2,2',3-triol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33502", "l": "H(+) + prephenate <=> 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-937034", "l": "IRAK1 phosphorylates Pellino (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027632", "l": "5-HEDH dehydrogenates 5-HEPE to 5-oxo-EPA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0072533", "l": "tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113402", "l": "Formation of DSIF:NELF:early elongation complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-990489", "l": "Kinesin-13 is a dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58113", "l": "1''-O-acetyl-ADP-alpha-D-ribose + H2O => acetate + ADP-D-ribose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50544", "l": "prostaglandin C2 = prostaglandin B2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20484", "l": "3'-phosphoadenylyl sulfate + coelenterazine h <=> adenosine 3',5'-bisphosphate + H(+) + luciferyl sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63672", "l": "(S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADH = H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49001", "l": "aurachin C + H(+) + NADH + O2 => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0016643", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor"}, {"i": "EC:1.4.7.-", "l": "\"With an iron-sulfur protein as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18938", "l": "an N-acyl-L-homoserine lactone + H2O => a carboxylate + L-homoserine lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42521", "l": "uridine(2605) in 23S rRNA => pseudouridine(2605) in 23S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0038102", "l": "activin receptor antagonist activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60150", "l": "(L-glutamyl)n+1-L-gamma-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate => (L-glutamyl)n-L-gamma-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2152276", "l": "Secretion of transmembrane collagens (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77589", "l": "Recognition of AAUAAA sequence by CPSF (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112727", "l": "Serine phosphorylation of STATs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40906", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> H(+) + hexadecanoate + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247847", "l": "WLS is endocytosed to the early endosome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60760", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-jasmololone = CoA + jasmolin II"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806629", "l": "Formation of tonofilament bundles (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14399", "l": "(4Z)-2-oxohept-4-enedioate + CO2 => (3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046810", "l": "host cell extracellular matrix binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39772", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807242", "l": "25(OH)D translocates from ER membrane to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26174", "l": "CoA + H(+) + mycothiol => 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34970", "l": "sn-glycerol 3-phosphate(in) <=> sn-glycerol 3-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51396", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + serotonin = CoA + H(+) + N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388900", "l": "Neurotensin receptors can bind neurotensins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36106", "l": "anthranilate + S-adenosyl-L-methionine <=> O-methyl anthranilate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54394", "l": "(9Z,12Z)-octadecadienoate + 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106258", "l": "L-serine-phosphatidylcholine phosphatidyltransferase activity"}, {"i": "RHEA:45088", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-984689", "l": "Kinesin-7 is a dimer (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140473", "l": "telomere-nuclear envelope anchor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60293", "l": "L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806831", "l": "CYB5Rs reduce MetHb to HbA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37993", "l": "beta-tocopherol + H(+) + S-adenosyl-L-homocysteine => delta-tocopherol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159773", "l": "Furin cleaves pro-protein S to protein S (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483219", "l": "PC is exchanged with PI by PITPNB (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16848", "l": "acetyl-CoA + H2O + oxaloacetate <=> citrate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52000", "l": "a 1-(methylsulfanyl)-4-aci-nitroalkane + glutathione = an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64801", "l": "NAD(+) + S-(2-aminoethyl)-L-cysteine => (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + 2 H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9734687", "l": "ORC6 is phosphorylated on T195 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.123"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850945", "l": "Casein kinase II phosphorylates PTEN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61118", "l": "(2R,3R)-dihydromyricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2R,3R)-dihydroquercetin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.207", "l": "\"Xyloglucan:xyloglucosyl transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37274", "l": "ATP + H2O + L-alanyl-L-glutamine(out) <=> ADP + H(+) + L-alanyl-L-glutamine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10643", "l": "muconolactone <=> cis,cis-muconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51793", "l": "H(+) + NADH + O2 + salicylate => 2,3-dihydroxybenzoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65599", "l": "4-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37079", "l": "2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36806", "l": "2-hydroxy-2,3-dihydrogenistein <=> genistein + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807106", "l": "PTEN undergoes monoubiquitination (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51015", "l": "a monoacyl-sn-glycero-3-phosphocholine + H2O <=> a monoacylglycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688786", "l": "ATXN3 binds RAD23 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44934", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45204", "l": "[Co(I) methanol-specific corrinoid protein] + H(+) + methanol = [methyl-Co(III) methanol-specific corrinoid protein] + H2O"}, {"i": "EC:2.1.1.90", "l": "\"Methanol--corrinoid protein Co-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176973", "l": "Association of MCM8 with ORC:origin complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40514", "l": "2,3-dihydroxypropane-1-sulfonate + NAD(+) <=> 3-sulfolactaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047100", "l": "glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25107", "l": "ATP + pyridoxamine <=> ADP + H(+) + pyridoxamine 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592247", "l": "Expression of ATP5B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421833", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371527", "l": "HSF1 trimer translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46010", "l": "H(+) + NADH + pentanoyl-CoA => CoA + NAD(+) + pentanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63787", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674019", "l": "BRAP binds KSR1:MARK3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72663", "l": "De novo formation of eIF2:GTP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035976", "l": "Defective HEXA does not cleave the terminall GalNAc from small HA fragments (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54383", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> 5-hydroxy-alpha-gurjunene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24319", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (+)-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52979", "l": "a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] <=> a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16514", "l": "(S)-lactate + O2 => acetate + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48055", "l": "n 3'-phosphoadenylyl sulfate + dermatan <=> n adenosine 3',5'-bisphosphate + dermatan 4'-sulfate + n H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47451", "l": "(5Z)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781953", "l": "YOD1 binds VCP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17941", "l": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O"}, {"i": "EC:4.2.1.99", "l": "\"2-methylisocitrate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25907", "l": "futalosine + H2O <=> dehypoxanthine futalosine + hypoxanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.9.1.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683772", "l": "Trimmed spike protein binds to calnexin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14013", "l": "3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + H(+) + taurolithocholate 3-sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64134", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + L-phenylalanine => H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31618", "l": "dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-adenosyl-L-methionine <=> dTDP-D-ravidosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15526", "l": "2-succinylbenzoyl-CoA => 1,4-dihydroxy-2-naphthoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5617828", "l": "TRIP11:IFT20 dissociates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50002", "l": "butan-1-ol + H2O + NAD(+) => butane + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951966", "l": "EP300 acetylates RUNX3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13426", "l": "a pyrimidine ribonucleoside 5'-phosphate + H2O => a pyrimidine nucleobase + D-ribose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57198", "l": "glycolate + H(+) + L-cysteinyl-[protein] => H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210881", "l": "Dimerization of Tie2/Ang1 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981355", "l": "RASA1 binds RAS:GTP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17372", "l": "glycyrrhizin + H2O <=> 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209094", "l": "Dissociation of free ubiquitinated and phosphorylated ARM from SLMB and the 'destruction complex' (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416516", "l": "GRK2 sequesters activated Gq (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030957", "l": "Tat protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559568", "l": "SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20590", "l": "glutaryl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71590", "l": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218836", "l": "PTK2beta binds alphaVbeta3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432295", "l": "GPVI binds Fyn and Lyn (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12970", "l": "a sn-glycero-3-phosphoester + H2O => an alcohol + H(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64768", "l": "S-3-(hexan-1-ol)-L-cysteine = 2-aminoprop-2-enoate + 3-sulfanyl-1-hexanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.3", "l": "\"RNA ligase (ATP)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49052", "l": "asperlicin C + H(+) + NADH + O2 = asperlicin E + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20848", "l": "H(+) + O2 + phosphate + pyruvate = acetyl phosphate + CO2 + H2O2"}, {"i": "EC:1.2.3.3", "l": "\"Pyruvate oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37774", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163120", "l": "Disassociation of Telomerase RNP and the Chromosome End (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2509838", "l": "ITPA hydrolyses dITP to dIMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044323", "l": "retinoic acid-responsive element binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66849", "l": "2 Cu(2+) + NADH => 2 Cu(+) + H(+) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14122", "l": "3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36987", "l": "CMP + phosphate = alpha-D-ribose 1,5-bisphosphate + cytosine"}, {"i": "EC:2.4.2.57", "l": "\"AMP phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247837", "l": "WNT ligands traffic to the Golgi (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19873", "l": "3beta-sulfooxy-androst-5-en-17-one + H2O = 3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate"}, {"i": "EC:3.1.6.2", "l": "\"Steryl-sulfatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10396", "l": "an L-alpha-amino acid + H2O + NAD(+) = a 2-oxocarboxylate + H(+) + NADH + NH4(+)"}, {"i": "EC:1.4.1.5", "l": "\"L-amino-acid dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102709", "l": "S-adenosyl-L-methionine:N,N-dimethyl-beta-alanine N-methyltransferase activity"}, {"i": "MetaCyc:RXN-6464"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33277", "l": "a 2-acylglycerol + a fatty acid + H(+) => a 1,2-diacyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19528", "l": "(2E,6E)-farnesyl diphosphate <=> (1S,8aR)-delta-cadinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37759", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43209", "l": "carboxymethyluridine(34) in tRNA + S-adenosyl-L-methionine => 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404142", "l": "atROL binds RBP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635854", "l": "GLI2,3 are degraded by the proteasome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19950", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate => 7,8-dihydropteroate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612501", "l": "SGK phosphorylates CREB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33761", "l": "a 3-hydroxy-fatty acyl-CoA + NADP(+) => a 3-oxo-fatty acyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109857", "l": "MAP2K1 binds MAPK3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27666", "l": "(R)-methylmalonyl-CoA + H(+) = CO2 + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13351", "l": "methyl (-)-jasmonate + S-adenosyl-L-homocysteine => jasmonate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55134", "l": "AMP + D-alanyl-[D-alanyl-carrier protein] + diphosphate => ATP + D-alanine + holo-[D-alanyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38755", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791387", "l": "TP53 binds the ARID3A gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70692", "l": "ornithine => putrescine + CO2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034539", "l": "3,3',5,5'-tetrabromobisphenol A reductive dehalogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8987007", "l": "p-STAT1 dimerizes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57888", "l": "a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.106", "l": "\"Fatty acid photodecarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12612", "l": "mercaptopurine + S-adenosyl-L-methionine <=> 6-methylthiopurine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54877", "l": "(4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one => (3S)-3-isopropenyl-6-oxoheptanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65714", "l": "beta-L-galactose 1-phosphate + GDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + GDP-beta-L-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33227", "l": "(E)-4-coumarate + H(+) = 4-hydroxystyrene + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2980720", "l": "NEK9 binds NEK6/NEK7 in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42404", "l": "H2O + lactose 6-phosphate = beta-D-glucose + D-galactose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62254", "l": "2 hydrogencarbonate(in) + Zn(2+)(in) => 2 hydrogencarbonate(out) + Zn(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.2.-", "l": "\"With ascorbate as one donor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10191", "l": "acetoacetyl-CoA + acetyl-CoA + H2O <=> (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189062", "l": "lactose + H2O => D-glucose + D-galactose (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18626", "l": "D-galactose + NADP(+) => D-galactono-1,5-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27401", "l": "2-hydroxychromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate"}, {"i": "EC:5.99.1.4", "l": "\"2-hydroxychromene-2-carboxylate isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26432", "l": "diphosphate + phyllocladan-16alpha-ol => (+)-copalyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944216", "l": "Association of procollagen type XV (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350769", "l": "trans-Golgi Network Coat Activation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070284", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-167429", "l": "The receptor:G-protein complex  binds GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176298", "l": "Activation of claspin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46930", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol => a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20400", "l": "L-cysteine + O-succinyl-L-homoserine <=> H(+) + L,L-cystathionine + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374681", "l": "L1 and NCAM1 engaged in cis-interaction (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12311", "l": "(S)-2-amino-6-oxohexanoate + H2O + NAD(+) <=> 2 H(+) + L-2-aminoadipate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797961", "l": "CHDH oxidises Cho to BETALD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34562", "l": "1-deoxy-11beta-hydroxypentalenate + NAD(+) <=> 1-deoxy-11-oxopentalenate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25798", "l": "4-methylsulfanyl-2-oxobutanoate + L-glutamate => 2-oxoglutarate + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44196", "l": "3-methylundecanoate + ATP + CoA = 3-methylundecanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1878002", "l": "XYLTs transfer Xyl to core protein (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36721", "l": "CoA + H(+) + N-hexacosenoylsphinganine => hexacosenoyl-CoA + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433374", "l": "Processing of SCF isoform 1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9679044", "l": "FKBP1A binds sirolimus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19411", "l": "3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH => cholate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11495", "l": "H(+) + O-phospho-L-threonine <=> (R)-1-aminopropan-2-yl phosphate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112385", "l": "Addition of nucleotides leads to transcript elongation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9634834", "l": "ACHEIs bind ACHE (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864999", "l": "TGFA gene expression is stimulated by the TFAP2A homodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29419", "l": "H(+)(out) + Na(+)(in) = H(+)(in) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42561", "l": "uridine(27/28) in mitochondrial tRNA => pseudouridine(27/28) in mitochondrial tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31210", "l": "FAD + H(+) + hexanoyl-CoA <=> (2E)-hexenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660514", "l": "MTF1 dimer:12Zn2+ binds CSRP1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23283", "l": "acetyl-CoA + cysteamine <=> CoA + S-acetylcysteamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606273", "l": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5622129", "l": "FABP5 binds atRA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654533", "l": "KRAS4B recycles to the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60990", "l": "(E)-hex--2-enal + H(+) + NADH => (E)-hex-2-en-1-ol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928632", "l": "ITSN1 exchanges GTP for GDP on CDC42, activating it (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38096", "l": "gamma-tocotrienol + S-adenosyl-L-methionine => alpha-tocotrienol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66759", "l": "ATP + domoate(in) + H2O <=> ADP + domoate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43672", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29015", "l": "phosphate(out) + sn-glycerol 3-phosphate(in) = phosphate(in) + sn-glycerol 3-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18341", "l": "D-xylono-1,4-lactone + H2O = D-xylonate + H(+)"}, {"i": "EC:3.1.1.68", "l": "\"Xylono-1,4-lactonase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.31"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48760", "l": "L-threitol + NAD(+) = H(+) + L-erythrulose + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13909", "l": "phosphate + urate D-ribonucleoside = alpha-D-ribose 1-phosphate + urate"}, {"i": "EC:2.4.2.16", "l": "\"Urate-ribonucleoside phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033208", "l": "UDP-N-acetylgalactosamine:N-acetylneuraminyl-alpha-2,3-galactosyl-beta-R 1,4-N-acetylgalactosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18930", "l": "AH2 + O2 + thiophene-2-carbonyl-CoA => 5-hydroxythiophene-2-carbonyl-CoA + A + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534206", "l": "E-cadherin degradation by PS1:NCSTN (Gamma-secretase) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15857", "l": "17alpha,20alpha-dihydroxypregn-4-en-3-one + NADP(+) = 17alpha-hydroxyprogesterone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35913", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14203", "l": "D-xylulose => D-lyxose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37917", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047169", "l": "galactarate O-hydroxycinnamoyltransferase activity"}, {"i": "KEGG.REACTION:R03727"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37578", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693243", "l": "RHOD translocates to the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57108", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39672", "l": "(9Z)-hexadecenoyl-CoA + AH2 + O2 => (9Z,12Z)-hexadecadienoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70481", "l": "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22805", "l": "(6S,9R)-vomifoliol + NAD(+) => (6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047129", "l": "opine dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65193", "l": "2 2-oxoglutarate + 2 O2 + preaustinoid A => berkeleytrione + 2 CO2 + H2O + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163320", "l": "Association of mTERF with the termination sequence (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351434", "l": "Phosphorylation of H2AX at S139 by ATM at the site of DSB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42246", "l": "3-oxopentanoyl-[ACP] + CO2 + CoA => H(+) + malonyl-[ACP] + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59549", "l": "N,N',N''-triacetylchitotriose + O2 => H2O2 + N,N',N''-triacetylchitotriono-1,5-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44401", "l": "3-demethylubiquinol-6 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38258", "l": "(S)-malate + succinyl-CoA <=> (S)-malyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5681980", "l": "ATG12 binds ATG7 dimer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50537", "l": "prostaglandin E2 => H2O + prostaglandin A2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102786", "l": "stearoyl-[acp] desaturase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005372", "l": "water transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32409", "l": "(1R,4S)-isodihydrocarvone + H(+) + NADH => (1R,2S,4S)-neoisodihydrocarveol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37076", "l": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine => 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58938", "l": "all-trans-lycopaoctaene + 2 diphosphate + NAD(+) => 2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50881", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-glycerol => 4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805792", "l": "p-S291-PHF20 translocates to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669024", "l": "CD70 binds CD27 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.13", "l": "\"Exo-(1->4)-alpha-D-glucan lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445714", "l": "Aquaporin-3 passively transports water out of cell (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70596", "l": "GOT2 dimer deaminates L-Asp (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52635", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP <=> [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23475", "l": "2 alpha,alpha'-trehalose 6-mycolate <=> alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2395364", "l": "LTBP4 binds TGF-Beta-1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008412", "l": "CDK4 phosphorylates RUNX2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40072", "l": "2-aminoprop-2-enoate + H2O => NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63083", "l": "AH2 + ATP + ilicicolinate B <=> A + AMP + diphosphate + ilicicolin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49854", "l": "(2E)-octenoyl-CoA => (3E)-octenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047814", "l": "D-arabinokinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3296326", "l": "HCAR1 binds LACT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033911", "l": "mycodextranase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012835", "l": "GDIs block activation of RHOA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38398", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O <=> (9Z)-hexadecenoate + 1,3-di-(9Z)-hexadecenoylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9650473", "l": "SERPING1 is secreted (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30648", "l": "1D-myo-inositol 3-phosphate + CTP + H(+) => CDP-1L-myo-inositol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62889", "l": "GDP-beta-L-fucose + lactose => beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-D-glucose + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.157", "l": "\"Iota-carrageenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374909", "l": "Metabolism of Noradrenaline (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060230", "l": "lipoprotein lipase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201622", "l": "Caspase-mediated cleavage of gelsolin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18303", "l": "AMP + diphosphate + GMP + 2 H(+) => ATP + NH4(+) + XMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12993", "l": "cyclohex-1-ene-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = cyclohexa-1,5-diene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]"}, {"i": "EC:1.3.8.10", "l": "\"Cyclohex-1-ene-1-carbonyl-CoA dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043749", "l": "phenol, water dikinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008412", "l": "CDK4 phosphorylates RUNX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785047", "l": "IL10 positively regulates extracellular inflammatory mediators (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981713", "l": "C4b binds to cell surface (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984012", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14791", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40359", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8873850", "l": "STARD5 binds DCA, LCA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53745", "l": "glycyl-tRNA(Ala) + H2O => glycine + H(+) + tRNA(Ala)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59079", "l": "bis(myo-inositol) 1,3'-phosphate + 2 GDP-alpha-D-mannose <=> 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + 2 GDP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23119", "l": "4-hydroxybenzoate + ATP + CoA <=> 4-hydroxybenzoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26189", "l": "1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine => 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0031893", "l": "vasopressin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56584", "l": "1,2-epoxypropane + H2O = propane-1,2-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781832", "l": "Defective MPI does not  isomerize Fru6P to Man6P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807106", "l": "PTEN undergoes monoubiquitination (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034282", "l": "ent-pimara-8(14),15-diene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54121", "l": "coelenterazine h + O2 => coelenterazine h dioxetanone"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015187", "l": "glycine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60781", "l": "2-oxoglutarate + gibberellin A15 + O2 => CO2 + gibberellin A24 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23253", "l": "[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O => [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25814", "l": "3-acetamidopropanal + H2O2 + putrescine => H2O + N(1)-acetylspermidine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211924", "l": "CYP4B1 12-hydroxylates ARA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390035", "l": "HPO dimer autophosphorylates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451900", "l": "IL2RB binds JAK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665767", "l": "Activated FMNL3 binds G-actin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57747", "l": "[protein]-disulfide + phylloquinol <=> [protein]-dithiol + phylloquinone"}]}
{"type": "biolink:MolecularActivity", "ic": "73.539748874002555", "identifiers": [{"i": "GO:0140102", "l": "catalytic activity, acting on a rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381087", "l": "Dimerization of PERK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20081", "l": "H2O + N-methylhexanamide = hexanoate + methylamine"}, {"i": "EC:3.5.1.39", "l": "\"Alkylamidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "81.20444558259193", "identifiers": [{"i": "GO:0016744", "l": "transketolase or transaldolase activity"}, {"i": "EC:2.2.1.-", "l": "\"Transketolases and transaldolases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20566", "l": "(2E)-geranyl diphosphate + H2O => (1S,2S,4R)-endo-fenchol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60891", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine-phospho-ribonucleoside in mRNA + H2O <=> (N(7)-methyl 5'-triphospho-guanosine)-guanosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55657", "l": "2 A + a carotenoid beta-end derivative => a carotenoid chi-end derivative + 2 AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814153", "l": "ADO oxidises 2AET to HTAU (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38910", "l": "(R)-reticuline + S-adenosyl-L-methionine <=> (R)-laudanine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014467", "l": "RHOG binds effectors at the ER membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54446", "l": "a (2R,3R)-dihydroflavonol + H(+) + NADPH => a (2R,3S,4S)-leucoanthocyanidin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0030580", "l": "quinone cofactor methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44235", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678998", "l": "Endosomal TLRs pass through the Golgi (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11724", "l": "[thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite = 3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol"}, {"i": "EC:1.8.4.8", "l": "\"Phosphoadenylyl-sulfate reductase (thioredoxin)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11132", "l": "chlorophyllide a + NADP(+) = H(+) + NADPH + protochlorophyllide a"}, {"i": "EC:1.3.1.33", "l": "\"Protochlorophyllide reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70494", "l": "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627089", "l": "CASP9 is phosphorylated at T125 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18505", "l": "L-lysine + NAD(+) = Delta(1)-piperideine-2-carboxylate + H(+) + NADH + NH4(+)"}, {"i": "EC:1.4.1.15", "l": "\"Lysine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389352", "l": "Translocation of Vav1 to CD28 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63913", "l": "6-azauridine + ATP => 6-azauridine 5'-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36205", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13978", "l": "D-serine => NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44781", "l": "2-demethylmenaquinol-9 + S-adenosyl-L-methionine => H(+) + menaquinol-9 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.99.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6789092", "l": "NOX2 generates superoxide anion from oxygen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13621", "l": "4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose = 1-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucose"}, {"i": "EC:5.4.99.15", "l": "\"(1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26015", "l": "3,7-dideoxy-D-threo-hepto-2,6-diuolosonate => 3-dehydroquinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008870", "l": "galactoside O-acetyltransferase activity"}, {"i": "MetaCyc:GALACTOACETYLTRAN-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140108", "l": "high-affinity glucose transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65863", "l": "A + Delta(1)-dihydrotestosterone + H2O <=> 17beta-hydroxyandrostan-1,3-dione + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48820", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16721", "l": "5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-Glu)(n) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420-(gamma-Glu)(n)"}, {"i": "EC:1.5.98.1", "l": "\"Methylenetetrahydromethanopterin dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65830", "l": "diphosphate + nerol => H2O + neryl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57713", "l": "(E)-sinapoaldehyde + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-4-trans-sinapoyl aldehyde + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65435", "l": "a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate <=> a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30914", "l": "a sphingomyelin + H2O <=> a carboxylate + sphing-4-enine-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3296309", "l": "HCAR3 binds HCAR3 ligands (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16476", "l": "cyclohexane-1,3-dione + H2O <=> 5-oxohexanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66643", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + koraiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44133", "l": "2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => 2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32336", "l": "(1S,2S,4R)-endo-fenchol + NADP(+) => (1S,4R)-fenchone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48606", "l": "2,3-dihydroxybenzoyl-[EntB isochorismatase/aryl-carrier protein] + AMP + H(+) => 2,3-dihydroxybenzoyl-5'-AMP + holo-[EntB isochorismatase/aryl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0008998", "l": "ribonucleoside-triphosphate reductase activity"}, {"i": "MetaCyc:1.17.4.2-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602484", "l": "Activation of proMMP11 by FURIN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24969", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => H2O + 2 oxidized [adrenodoxin] + secalciferol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49719", "l": "3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + H(+) + NADH + O2 <=> 3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3858475", "l": "ppDVL recruits RAC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36354", "l": "AH2 + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-methionine <=> 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + A + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47686", "l": "[(1->2)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate => [(1->2)-beta-D-glucosyl](n) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901514", "l": "ATPase-coupled lipo-chitin oligosaccharide transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666008", "l": "SCAI binds SRF:MKL1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42749", "l": "cytidine(967) in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13019", "l": "5-phospho-alpha-D-ribose 1-diphosphate + uracil => diphosphate + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15000", "l": "deoxylimonoate + H2O <=> deoxylimononate D-ring-lactone + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49602", "l": "AMP + diphosphate + octanedioyl-CoA => ATP + CoA + octanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16067", "l": "2-hydroxyphytanoyl-CoA + CO2 + succinate => 2-oxoglutarate + O2 + phytanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168934", "l": "MAVS interacts with RIPK1 and FADD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35221", "l": "8-oxo-dAMP + H(+) + phosphate => 8-oxo-dADP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63949", "l": "H2O + sphinga-4E,14Z-dienine-1-phosphate => phosphate + sphinga-4E,14Z-dienine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061990", "l": "beta-ketodecanoyl-[acyl-carrier-protein] synthase activity"}, {"i": "RHEA:42264", "l": "H(+) + malonyl-[ACP] + octanoyl-CoA = 3-oxodecanoyl-[ACP] + CO2 + CoA"}, {"i": "MetaCyc:RXN-13613"}, {"i": "EC:2.3.1.207", "l": "\"Beta-ketodecanoyl-[acyl-carrier-protein] synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707594", "l": "Hemes bind LY96 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3782655", "l": "HDAC10 deacetylates histone (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47831", "l": "ganglioside GT1b + H2O <=> ganglioside GD1b + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389756", "l": "AKT interacts and phosphorylates Cot (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810899", "l": "TGM1 and involucrin bind the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199935", "l": "MSK1 activates CREB (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187828", "l": "Translocation of p21 to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603379", "l": "TPMT does not transfer CH3 from AdoMet to 6MP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38389", "l": "(9Z)-octadecenoate + 1,3-di-(9Z-octadecenoyl)-glycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.44"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11717", "l": "a monoamide of a dicarboxylate + H2O => a dicarboxylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "78.819800280251172", "identifiers": [{"i": "GO:0038024", "l": "cargo receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22282", "l": "H(+) + puromycin + S-adenosyl-L-homocysteine => O-demethylpuromycin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2317332", "l": "PIP3 recruits AKT to the membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.72", "l": "\"Branched-chain-2-oxoacid decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694441", "l": "CSNK1D phosphorylates SEC23 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169461", "l": "MCM8 mediated fork unwinding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51979", "l": "an L-N-hydroxypolyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> an L-N,N-dihydroxypolyhomomethionine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047287", "l": "lactosylceramide alpha-2,6-N-sialyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60752", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-jasmololone = CoA + jasmolin I"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190256", "l": "FGFR1c binds to FGF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27680", "l": "ADP + dCTP => ATP + dCDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21149", "l": "indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose => 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41131", "l": "1-decanoyl-sn-glycero-3-phosphocholine + H2O = 1-decanoyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20746", "l": "15-oxoprostaglandin D2 + H(+) + NADPH => NADP(+) + prostaglandin D2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38150", "l": "carbon disulfide + H2O <=> carbonyl sulfide + H(+) + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52088", "l": "5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA = 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12793", "l": "1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59322", "l": "4-O-beta-D-glucopyranosyl-D-gluconate + H(+) => D-cellobiono-1,5-lactone + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0023028", "l": "MHC class I protein binding, via lateral surface"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21984", "l": "3'-phosphoadenylyl sulfate + choline = adenosine 3',5'-bisphosphate + choline sulfate + H(+)"}, {"i": "EC:2.8.2.6", "l": "\"Choline sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51092", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629497", "l": "NEIL3 cleaves thymine glycol from telomeric DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672973", "l": "MAP2Ks phosphorylate MAPKs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607756", "l": "TRAF6 oligomer autoubiquitinates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051380", "l": "norepinephrine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18702", "l": "arsenite + H2O + 2 oxidized [azurin] => arsenate + 3 H(+) + 2 reduced [azurin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-156682", "l": "PLK1 phosphorylates NUDC (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53530", "l": "1,2-diheptadecanoyl-sn-glycero-3-phospho-N-(9Z-octadecenoyl)-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.59"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690669", "l": "CD22 binds itself to form homo-oligomers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205321", "l": "Interaction of KIT and sSCF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48748", "l": "D-threitol + NAD(+) = D-erythrulose + H(+) + NADH"}, {"i": "EC:1.1.1.403", "l": "\"D-threitol dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390673", "l": "CHRM2,4 bind acetylcholine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64186", "l": "(9Z)-octadecenoate + L-tyrosine => H2O + N-(9Z-octadecenoyl)-L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59798", "l": "CoA + H(+) + N(6)-dodecanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] => dodecanoyl-CoA + L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62831", "l": "GDP-beta-L-fucose + methyl-8-{[beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44174", "l": "2 H(+) + NADH + tetradecanoate => H2O + NAD(+) + tetradecanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26272", "l": "Co-precorrin-2 + 3 H(+) <=> Co(2+) + precorrin-2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64058", "l": "(R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH => (1S,2R)-ephedrine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043830", "l": "thiol-driven fumarate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "72.96845868813736", "identifiers": [{"i": "GO:0022832", "l": "voltage-gated channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35791", "l": "2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-kanosamine = H(+) + kanamycin X + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675656", "l": "EDA:EDAR binds EDARADD (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19367", "l": "ADP + D-ribulose 1,5-bisphosphate + H(+) => ATP + D-ribulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24837", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate => 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57783", "l": "2-chloro-4-nitrotoluene + NADH + O2 <=> 3-chloro-4-methylcatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687284", "l": "DMBT1 binds SFTPD 12mer, SFTPAs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47510", "l": "isolithocholate + NAD(+) => 3-oxo-5beta-cholan-24-oate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52471", "l": "16alpha,17beta-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112510", "l": "IL6ST is tyrosine phosphorylated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61270", "l": "2-oxohexanoate + H2O2 + NH4(+) => H2O + L-2-aminohexanoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46172", "l": "ATP + butanoate + CoA = AMP + butanoyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204981", "l": "14-3-3epsilon attentuates NADE-related apoptosis (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56956", "l": "ITP + pyruvate = H(+) + IDP + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25211", "l": "acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2106614", "l": "Duplex miRNA is loaded into Argonaute (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21613", "l": "D-gluconate => 2-dehydro-3-deoxy-D-gluconate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56185", "l": "globoside Gb4Cer + UDP-alpha-D-galactose => globoside NOR1 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785762", "l": "IL13RA1 binds TYK2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56730", "l": "4,4-dihydroxy-all-trans-beta-carotene + A + H2O => 4-hydroxy-all-trans-beta-carotene + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419490", "l": "Binding of ATP to P2X receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28816", "l": "4-hydroxybenzoate(in) + H(+)(out) => 4-hydroxybenzoate(out) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48049", "l": "ganglioside GM1 (d18:1(4E)) + H2O => D-galactose + ganglioside GM2 (d18:1(4E))"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211206", "l": "Translocation of DFF to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227732", "l": "IPS1 interacts with TRADD, RIP1 and FADD (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15975", "l": "adenosine 3',5'-bisphosphate + estrone 3-sulfate + H(+) => 3'-phosphoadenylyl sulfate + estrone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956639", "l": "RUNX1 binds YAP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23261", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NAD(+) => 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952371", "l": "MDM2 binds RUNX3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.13.1.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21220", "l": "L-dopa + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)"}, {"i": "EC:1.13.11.29", "l": "\"Stizolobate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31647", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate"}, {"i": "EC:3.2.1.180", "l": "\"Unsaturated chondroitin disaccharide hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38185", "l": "19-oxotestosterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 19-hydroxytestosterone + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-912627", "l": "CBL ubiquitinates PI3K (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685607", "l": "Sialic acid binds SIGLEC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008198", "l": "ferrous iron binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49506", "l": "phosphinomethylisomalate => phosphinomethylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23977", "l": "(RNA)-3'-(3'-phosphooxy-ribonucleotide) + ATP => (RNA)-3'-(2',3'-cyclophosphooxy)-ribonucleotide + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199404", "l": "CD40L binds CD40 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029158", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693111", "l": "RHOF auto-activates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34213", "l": "ecgonone methyl ester + H(+) + NADPH => ecgonine methyl ester + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5138432", "l": "DVL2 is phosphorylated by PKC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60808", "l": "gibberellin A19 + H(+) + O2 = CO2 + gibberellin A20 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.2.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16872", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30154", "l": "FADH2 + NADP(+) <=> FAD + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2025890", "l": "Calcineurin binds NFATC1,2,3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26194", "l": "(S)-malate + ATP + CoA => (S)-malyl-CoA + ADP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39103", "l": "(24R)-ethylcholest-5-en-3beta-ol(in) + ATP + H2O = (24R)-ethylcholest-5-en-3beta-ol(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55999", "l": "H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] <=> beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21294", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21711", "l": "H2O + S-adenosyl-L-homocysteine <=> adenosine + L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62824", "l": "beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + GDP-beta-L-fucose = beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosamine + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34460", "l": "8-hydroxycopalyl diphosphate + H2O => diphosphate + sclareol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008684", "l": "TBK1 phosphorylation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32285", "l": "H(+) + H2O + quinolinate => 3-hydroxyanthranilate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35757", "l": "H(+) + NADH + UDP-3-oxo-alpha-D-glucose => NAD(+) + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60920", "l": "2-oxoglutarate + an N(3)-methylcytidine in mRNA + O2 = a cytidine in mRNA + CO2 + formaldehyde + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399997", "l": "AKT1 E17K mutant translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51968", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52869", "l": "17alpha-estradiol + UDP-alpha-D-glucuronate => 17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29751", "l": "acetoacetate(in) = acetoacetate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445448", "l": "HHIP binds Hedgehog (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40014", "l": "(+)-copalyl diphosphate + H2O <=> diphosphate + manool"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376141", "l": "Interaction of ABL with ROBO1:SLIT2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23992", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA = 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA"}, {"i": "EC:2.3.1.63", "l": "\"1-alkylglycerophosphocholine O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52021", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 => A + H2O + resolvin E2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18848", "l": "(R)-glycerate + NAD(+) <=> 2-hydroxy-3-oxopropanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0009019", "l": "tRNA (guanine-N1-)-methyltransferase activity"}, {"i": "REACT:R-HSA-6787591", "l": "TRMT10C:HSD17B10 (TRMT10C:SDR5C1) of mitochondrial RNase P methylates guanosine-9 in tRNA yielding 1-methylguanosine-9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48311", "l": "2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O <=> (3Z)-6-oxohex-3-enoyl-CoA + formate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72722", "l": "eIF2 activation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654515", "l": "KAL1 binds HS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33781", "l": "6,6-kestotetraose + beta-D-glucose => 6-kestotriose + sucrose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676133", "l": "CD74 binds MIF (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11115", "l": "H2O + isochorismate <=> (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050647", "l": "5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58763", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + NADPH <=> 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782388", "l": "NSUN2 methylates cytidine-34, cytidine-48 of unspliced tRNA(Leu)(CAA) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11541", "l": "an N-acyl-D-mannosamine + NAD(+) => an N-acyl-D-mannosaminolactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800797", "l": "The PIDDosome activates CASP2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20468", "l": "[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177920", "l": "Binding of GRB2 to GAB1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40272", "l": "O2 + tetradecanedioyl-CoA => (2E)-tetradecenedioyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44765", "l": "2-methoxy-6-all-trans-decaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392152", "l": "Soluble guanylate cyclase converts GTP to cGMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158118", "l": "factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70241", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160906", "l": "20kDa HA fragments are translocated to lysosomes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008681", "l": "2-octaprenyl-6-methoxyphenol hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45502", "l": "(2R,3E)-phycocyanobilin + apo-[allophycocyanin beta-subunit] => [allophycocyanin beta-subunit]-Cys(84)-phycocyanobilin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15085", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O = an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + N-acetyl-D-galactosamine"}, {"i": "EC:3.2.1.49", "l": "\"Alpha-N-acetylgalactosaminidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013435", "l": "RHOD auto-activates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177926", "l": "Dephosphorylation of PAG by SHP2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14813", "l": "L-2-aminohexano-6-lactam = D-2-aminohexano-6-lactam"}, {"i": "EC:5.1.1.15", "l": "\"2-aminohexano-6-lactam racemase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40940", "l": "1-O-hexadecylglycerone 3-phosphate + H(+) + NADPH => 1-O-hexadecyl-sn-glycero-3-phosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453339", "l": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004692", "l": "cGMP-dependent protein kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904067", "l": "ascr#2 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38192", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone => 17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55052", "l": "H2O + pentanoyl-CoA = CoA + H(+) + pentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110319", "l": "Elongation by POLH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49318", "l": "(5R,6S)-5,6-epoxi-beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390598", "l": "Myosin Binds ATP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60206", "l": "CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865774", "l": "TTLLs polyglutamylate tubulin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3149539", "l": "MTR transfers CH3 group from MTHF to cob(I)alamin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018446", "l": "pinocarveol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51804", "l": "deoxyhumulone + dimethylallyl diphosphate = diphosphate + H(+) + lupulone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39741", "l": "3,12-dihydroxydodecanoate + H2O + NADP(+) => 3-hydroxydodecanoate + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56322", "l": "an anthocyanin 5-O-beta-D-glucoside + H(+) + UDP => a 5-hydroxy anthocyanidin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35480", "l": "(1'S,5'R)-5'-hydroxyaverantin + NAD(+) => (S)-5'-oxoaverantin + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24361", "l": "2 H(+) + siroheme => Fe(2+) + sirohydrochlorin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15962", "l": "4-hydroxymandelonitrile + UDP-alpha-D-glucose => H(+) + taxiphyllin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296043", "l": "Activation of HCN channels (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006585", "l": "PTPN4 gene expression is stimulated by MECP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624953", "l": "ARL13B binds INPP5E (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24295", "l": "acetyl-CoA + L-glutamate <=> CoA + H(+) + N-acetyl-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805022", "l": "USP2 binds the heterodimer of MDM2 and MDM4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53540", "l": "(13R)-S-cysteinylglycinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O = (13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15884", "l": "ATP + L-seryl-[Fas-activated protein] <=> ADP + H(+) + O-phospho-L-seryl-[Fas-activated protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371554", "l": "HSF1 acetylation at Lys80 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507873", "l": "Aquaporins passively transport urea out of cells (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452958", "l": "Expression of SALL1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168306", "l": "Concerted hemagglutinin pore formation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39239", "l": "(2E)-triacontenoyl-CoA + H(+) + NADPH = NADP(+) + triacontanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41121", "l": "1-hexadecanoyl-sn-glycerol + H(+) + phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60230", "l": "CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008781", "l": "N-acylneuraminate cytidylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9690493", "l": "RHOB binds effectors on endosomes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45983", "l": "3-oxochol-4-en-22-oyl-CoA + H(+) + NADH + O2 <=> 9alpha-hydroxy-3-oxochol-4-en-22-oyl-CoA + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847977", "l": "FRK phosphorylates PTEN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46335", "l": "2 [Fe(II)-cytochrome b5] + a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16962", "l": "epsilon-(gamma-L-glutamyl)-L-lysine => 5-oxo-L-proline + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691004", "l": "XPC binds RAD23 and CETN2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12160", "l": "2-deoxy-D-gluconate + NAD(+) = 3-dehydro-2-deoxy-D-gluconate + H(+) + NADH"}, {"i": "EC:1.1.1.125", "l": "\"2-deoxy-D-gluconate 3-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35961", "l": "demethoxyfumitremorgin C + 2 H2O + NADP(+) => H(+) + NADPH + O2 + tryprostatin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25878", "l": "H2O2 + iminosuccinate => L-aspartate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442345", "l": "hZIP10 mediates zinc influx into cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63679", "l": "CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+) <=> (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047787", "l": "delta4-3-oxosteroid 5beta-reductase activity"}, {"i": "EC:1.3.1.3", "l": "\"Delta(4)-3-oxosteroid 5-beta-reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55800", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + N-acyleicosasphinganine + O2 = 2 [Fe(III)-cytochrome b5] + 2 H2O + N-acyleicosasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31393", "l": "all-trans-4,4'-diapolycopene + 4 FADH2 => 15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004155", "l": "6,7-dihydropteridine reductase activity"}, {"i": "REACT:R-HSA-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37153", "l": "1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29847", "l": "(2E)-tetradecenoyl-CoA = (3Z)-tetradecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204850", "l": "Interaction of Tie2 and Dok-2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174058", "l": "Degradation of multiubiquitinated Cdh1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672304", "l": "IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453337", "l": "glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-421831", "l": "trans-Golgi Network Coat Assembly (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31088", "l": "acetyl-CoA + octanoyl-CoA => 3-oxodecanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5576895", "l": "SCNAs:SNCBs transport Na+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2530429", "l": "Formation of soluble VTN:C5b-C9  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-167415", "l": "G-protein alpha subunit is inactivated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.30", "l": "\"Pycnoporopepsin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21232", "l": "L-histidine = NH4(+) + trans-urocanate"}, {"i": "EC:4.3.1.3", "l": "\"Histidine ammonia-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24214", "l": "4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+) => 5-(2-hydroxyethyl)-4-methylthiazole + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10034", "l": "[protein]-C-terminal-L-glutamate + NH4(+) => [protein]-C-terminal-L-glutamine + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0033284", "l": "ATPase-coupled carboxylic acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28656", "l": "glutathione S,S-dioxide + H2O => glutathione + H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165680", "l": "Formation of active mTORC1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102981", "l": "4-hydroxy-5-methyl-2-propyl-3(2H)-furanone oxidoreductase activity"}, {"i": "MetaCyc:RXN-9567"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "60.34429001122367", "identifiers": [{"i": "GO:0001664", "l": "G protein-coupled receptor binding"}, {"i": "REACT:R-HSA-500717", "l": "Activation of GRIK3 homomer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047323", "l": "[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21405", "l": "chloride + O2 => chlorite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196017", "l": "Dynamin is recruited to the gap junction plaque (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28736", "l": "H(+)(in) + spermidine(out) => H(+)(out) + spermidine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37273", "l": "ADP + H(+) + L-alanyl-L-glutamine(in) + phosphate => ATP + H2O + L-alanyl-L-glutamine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433395", "l": "Dimerization of sSCF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014812", "l": "ROBOs bind keratan sulfate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11539", "l": "choline + H2O + 2 O2 <=> glycine betaine + H(+) + 2 H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.n3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10424", "l": "H2O + N-benzoylglycine = benzoate + glycine"}, {"i": "EC:3.5.1.32", "l": "\"Hippurate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9688832", "l": "MLKL binds PDCD6IP and SDCBP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1299359", "l": "Activation of TALK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53755", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-beta-D-galactopyranosyl]-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052672", "l": "CTP:geranylgeraniol kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40488", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21142", "l": "ADP + H(+) + IMP => ATP + inosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54626", "l": "2-hydroxyoctadecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + O2 + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55336", "l": "a 5'-hydroxy-3'-methoxyflavone + S-adenosyl-L-methionine = a 3',5'-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782138", "l": "ERCC5 and RPA bind TC-NER site (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420265", "l": "AMY1-3 bind IAPP(34-70) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20070", "l": "(Z)-phenylacetaldehyde oxime => H2O + phenylacetonitrile"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20701", "l": "ATP + lipid A disaccharide (E. coli) => ADP + H(+) + lipid IVA (E. coli)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56896", "l": "a carboxylate + ATP + H(+) = an acyl-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64019", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose <=> alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-Glc + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25299", "l": "acetaldehyde + H2O + NADP(+) => acetate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016760", "l": "cellulose synthase (UDP-forming) activity"}, {"i": "RHEA:19929", "l": "[(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP"}, {"i": "EC:2.4.1.12", "l": "\"Cellulose synthase (UDP-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112042", "l": "Opioid binds MOR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047406", "l": "beta-aspartyl-N-acetylglucosaminidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23943", "l": "D-gluconate + NAD(+) <=> 5-dehydro-D-gluconate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "81.20444558259193", "identifiers": [{"i": "GO:0042285", "l": "xylosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25880", "l": "2 L-dopa + O2 = 2 3-(3,4-dihydroxyphenyl)pyruvate + 2 NH4(+)"}, {"i": "EC:1.13.12.15", "l": "\"3,4-dihydroxyphenylalanine oxidative deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45375", "l": "H2O + N-(9Z-octadecenoyl)-sphinganine <=> (9Z)-octadecenoate + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28620", "l": "2-hydroxy-2-methylbutanenitrile + H2O + NADP(+) => 2-methylbutyronitrile + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9606151", "l": "Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5140741", "l": "WNT5A binds FZD and ROR receptors (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390930", "l": "5-HT2 receptor can bind serotonin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10704", "l": "ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)"}, {"i": "EC:6.1.1.9", "l": "\"Valine--tRNA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606312", "l": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12008", "l": "[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+)"}, {"i": "EC:2.7.11.16", "l": "\"[G-protein-coupled receptor] kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42953", "l": "cytidine(49) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(49) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41124", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43710", "l": "diphosphate + hexadecanoyl-AMP => ATP + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60122", "l": "H(+) + pre-sodorifen diphosphate + S-adenosyl-L-homocysteine => (2E,6E)-farnesyl diphosphate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848436", "l": "PTK6 phosphorylates CDKN1B (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24453", "l": "L-glutamyl-[protein] + S-adenosyl-L-methionine => [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38840", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9671145", "l": "DKC1 binds SHQ1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29442", "l": "Fe(2+)(in) + H(+)(out) <=> Fe(2+)(out) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65214", "l": "(2E)-dodecenoate + CoA + H(+) => (2E)-dodecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874197", "l": "CREB3 translocates from the cytosol to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804035", "l": "N2O3 diffuses to phagosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37425", "l": "aclacinomycin A + H2O2 => aclacinomycin N + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16746", "l": "AH2 + O2 + phylloquinone => 2,3-epoxyphylloquinone + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28057", "l": "2-oxobutanoate + CoA <=> formate + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28830", "l": "L-ornithine(out) + putrescine(in) <=> L-ornithine(in) + putrescine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948709", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193964", "l": "CYP21A2 21-hydroxylates PROG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432956", "l": "BP230 is recruited to the hemidesmosome (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030772", "l": "tryptophan 2-C-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202164", "l": "Translocation of PDK1 to Plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197963", "l": "DHFR2 reduces FOLA to DHF (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61525", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => (15S)-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67004", "l": "a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3204303", "l": "MRE11 binds cytosolic DNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39257", "l": "(3R)-hydroxy-(13Z)-docosenoyl-CoA + NADP(+) => (13Z)-3-oxodocosenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322427", "l": "Beta-catenin recruits CBP/p300 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17390", "l": "D-arabinitol + NAD(+) => D-ribulose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450474", "l": "MK2 phosphorylates BRF1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111970", "l": "PKC phosphorylates GRK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981926", "l": "RAC1 and CDC42 activate PAK3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351341", "l": "Exocytosis of Proactivator polypeptide (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40563", "l": "dTDP-N-hydroxy-beta-L-evernosamine + H(+) + NADPH + O2 = dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33223", "l": "2-oxobutanoate + CoA + NAD(+) = CO2 + NADH + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23821", "l": "GDP-alpha-D-mannose => GDP-4-dehydro-alpha-D-rhamnose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950778", "l": "p-Y693-STAT4 dimerizes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39309", "l": "(11Z,14Z)-eicosadienoyl-CoA + NADP(+) => (2E,11Z,14Z)-eicosatrienoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71164", "l": "homogentisate + O2 => maleylacetoacetate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928608", "l": "LIMK phosphorylates CFL1, inactivating it (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55828", "l": "cortisol + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444202", "l": "Receptor FFAR1 binds free fatty acids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1067659", "l": "Assembly of hexameric IL-6 receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23417", "l": "(2R)-O-phospho-3-sulfolactate + H2O => (R)-3-sulfolactate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13142", "l": "2-methylpropanoyl-CoA => butanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.13", "l": "\"Sterol esterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005125", "l": "cytokine activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.38", "l": "\"Coagulation factor XIIa\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27519", "l": "H2O + sphing-4-enine 1-phosphate => phosphate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.17", "l": "\"Non-stereospecific dipeptidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061787", "l": "peptidoglycan cross-bridge peptide endopeptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375160", "l": "NCAM1 binds to ATP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917839", "l": "apo-Transferrin dissociates from the receptor complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666428", "l": "DOCK180 exchanges GTP for GDP on RAC1:GDP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941312", "l": "ZCCHC6, ZCCHC11 are mRNA uridyltransferases (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030789", "l": "precorrin-3B C17-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32021", "l": "beta-cubebene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032561", "l": "guanyl ribonucleotide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43594", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral => all-trans-zeaxanthin + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39196", "l": "3-oxotetracosanoyl-CoA + H(+) + NADPH => (3R)-hydroxytetracosanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25732", "l": "H(+) + N,N-dihydroxy-L-tetrahomomethionine => (E)-7-(methylsulfanyl)heptanal oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870466", "l": "RGGT:CHM binds RABs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54403", "l": "1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2197691", "l": "WIP binds WASP,N-WASP, activating them (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51195", "l": "(R)-2-hydroxyglutarate + NADP(+) <=> 2-oxoglutarate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39892", "l": "devancoaminyl-vancomycin + dTDP-beta-L-vancosamine => dTDP + H(+) + vancomycin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16942", "l": "N-acetylindoxyl + O2 => H2O + N-acetylisatin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951676", "l": "RUNX3 binds TEADs and YAP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1467466", "l": "ABCA4 mediates atRAL transport (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25870", "l": "3-acetamidopropanal + H2O2 + N(1)-acetylspermidine => H2O + N(1),N(12)-diacetylspermine + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033970", "l": "N-malonylurea hydrolase activity"}, {"i": "KEGG.REACTION:R07629"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635839", "l": "ULK3:SUFU dissociates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44921", "l": "(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH => (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5662466", "l": "XYLB phosphorylates D-xylulose (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28418", "l": "(R)-carnitine + gamma-butyrobetainyl-CoA = (R)-carnitinyl-CoA + 4-(trimethylamino)butanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624494", "l": "RAF1 binds p21 RAS:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018523", "l": "quinoline 2-oxidoreductase activity"}, {"i": "MetaCyc:1.3.99.17-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39888", "l": "2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pikromycin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43485", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43960", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29409", "l": "2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP(+) => 2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58655", "l": "rifamycin SV ortho-naphthoquinone carboxamide <=> rifamycin SV para-naphthoquinone carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42160", "l": "(11Z,14Z)-eicosadienoyl-CoA + AH2 + O2 = (5Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29774", "l": "arsenate(in) + ATP + H2O <=> ADP + arsenate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55413", "l": "[phosphate](n) + GTP => [phosphate](n+1) + GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48722", "l": "4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH => aurachin B + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19532", "l": "isovitexin + UDP-alpha-D-glucose <=> H(+) + isovitexin 2''-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204500", "l": "CyP60 chaperones Basigin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63489", "l": "9,10-phenanthroquinone + H(+) + NADPH => NADP(+) + phenanthrene-9,10-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610726", "l": "The IFT-A complex recruits TULP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35819", "l": "5,6,7,8-tetrahydromethanopterin + NADP(+) = 7,8-dihydromethanopterin + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23104", "l": "D-arabinose 5-phosphate = D-ribulose 5-phosphate"}, {"i": "EC:5.3.1.13", "l": "\"Arabinose-5-phosphate isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43507", "l": "5-hydroxymethylfurfural + O2 <=> 2,5-diformylfuran + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26056", "l": "GTP + H(+) + valienol 1-phosphate => diphosphate + GDP-valienol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169680", "l": "IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382057", "l": "Release of novel PDGFs as latent factors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047321", "l": "diphosphate-protein phosphotransferase activity"}, {"i": "MetaCyc:2.7.99.1-RXN"}, {"i": "EC:2.7.99.1", "l": "\"Triphosphate--protein phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42674", "l": "H2O + L-gamma-glutamyl-hercynylcysteine S-oxide => hercynine + L-gamma-glutamyl-L-cysteine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12943", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56154", "l": "(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA => (9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62273", "l": "4 (R)-2-hydroxy-3-methylbutyrate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + bassianolide + 8 diphosphate + 8 H(+) + 4 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003919", "l": "FMN adenylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18433", "l": "cyclohexylamine + H2O + O2 = cyclohexanone + H2O2 + NH4(+)"}, {"i": "EC:1.4.3.12", "l": "\"Cyclohexylamine oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850961", "l": "PREX2 binds PTEN and inhibits it (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47524", "l": "cholate + NAD(+) = 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16170", "l": "ATP + L-glutamate + NH4(+) => ADP + H(+) + L-glutamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102855", "l": "1-18:1-2-18:2-phosphatidylcholine desaturase activity"}, {"i": "RHEA:46332", "l": "2 [Fe(II)-cytochrome b5] + a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O"}, {"i": "EC:1.14.19.22", "l": "\"Acyl-lipid omega-6 desaturase (cytochrome b5)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202966", "l": "Caspase mediated cleavage of HIP-55 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009485", "l": "IL34:CSF1 binds CSF1R (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870469", "l": "RGGT geranylgeranylates RAB proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.313", "l": "\"25S rRNA (uracil(2634)-N(3))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047550", "l": "2-oxoadipate reductase activity"}, {"i": "RHEA:14793", "l": "2-hydroxyadipate + NAD(+) = 2-oxoadipate + H(+) + NADH"}, {"i": "EC:1.1.1.172", "l": "\"2-oxoadipate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46334", "l": "2 [Fe(III)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O => 2 [Fe(II)-cytochrome b5] + a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975880", "l": "MyD88 oligomerization within the complex of activated TLR:MyD88 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952419", "l": "SMURFs ubiquitinate RUNX3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37788", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63004", "l": "(11Z,14Z)-eicosadienamide + H2O = (11Z,14Z)-eicosadienoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373717", "l": "DCC interacts with DIP13alpha (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046537", "l": "2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58136", "l": "acetate + ATP + H(+) = acetyl-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.203"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.5", "l": "\"Tyrosine transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070539", "l": "linoleic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29019", "l": "D-galactose(in) + H(+)(in) = D-galactose(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16128", "l": "ATP + D-fructose <=> ADP + D-fructose 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030395", "l": "lactose binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852010", "l": "BTNL2 binds activated T cells surface (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66059", "l": "indole-3-pyruvate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203662", "l": "eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55770", "l": "all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP => all-trans-retinoate + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45839", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620717", "l": "p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29513", "l": "(+)-valencene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3149519", "l": "MMACHC decyanates CNCbl (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54484", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphocholine = 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43378", "l": "5-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine => 5'-deoxyinosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42850", "l": "8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + dTDP + H(+) => 8-demethyltetracenomycin C + dTDP-beta-L-rhamnose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39087", "l": "decanedioyl-CoA + O2 = (2E)-decenedioyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193706", "l": "Production of ceramide which can activate JNK and other targets (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854052", "l": "Formation of the SCF-FBXL7 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209960", "l": "Diiodinated tyrosine can be deiodinated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099108", "l": "potassium channel activator activity involved in G protein-coupled receptor signaling pathway"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54706", "l": "H(+) + N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17057", "l": "a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP] = a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP]"}, {"i": "EC:2.3.1.141", "l": "\"Galactosylacylglycerol O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12372", "l": "2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O = 4-oxohex-2-enedioate + H(+)"}, {"i": "EC:3.1.1.45", "l": "\"Carboxymethylenebutenolidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35213", "l": "dIMP + H(+) + phosphate => dIDP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47590", "l": "CMP + ganglioside GQ1c (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GT1c (d18:1(4E))"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48274", "l": "2-methylhexenoyl-CoA + reduced [electron-transfer flavoprotein] => 2-methylhexanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19559", "l": "9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O => AH2 + O2 + pregna-4,9(11)-diene-3,20-dione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17892", "l": "H2O + phosphoethanolamine <=> acetaldehyde + NH4(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9674095", "l": "PDGFRs bind type II TKI (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5604975", "l": "Defective UGT1A1 does not transfer GlcA from UDP-GlcA to BIL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018732", "l": "sulfolactone hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52977", "l": "a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] => a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683831", "l": "CCDC59 binds TTF1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161282", "l": "Elastic fibres bind associated proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430311", "l": "Rsu-1 interacts with Pinch1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53065", "l": "2-methoxyestrone + UDP-alpha-D-glucuronate => 2-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39586", "l": "(2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H(+) + NADPH <=> (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202709", "l": "JAM2 dimerises (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14417", "l": "acetyl phosphate + L-lysine = H(+) + N(6)-acetyl-L-lysine + phosphate"}, {"i": "EC:2.3.1.32", "l": "\"Lysine N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14267", "l": "5-aminolevulinate => (S)-4-amino-5-oxopentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53267", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 2beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982768", "l": "GH:GHR:JAK2 complex undergoes a conformational change (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24779", "l": "H2O + pheophorbide a <=> C-13(2)-carboxypyropheophorbide a + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51708", "l": "D-altritol + NAD(+) = H(+) + keto-D-tagatose + NADH"}, {"i": "EC:1.1.1.407", "l": "\"D-altritol 5-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001647", "l": "G protein-coupled cytokinin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201521", "l": "ALK autophosphorylation downstream of PTN and MDK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66538", "l": "25-hydroxycholest-4,6-dien-3-one + AH2 => A + cholest-4,6-dien-3-one + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.13", "l": "\"(6-4)DNA photolyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168640", "l": "Ubiquitinated IkB is degraded (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28049", "l": "phosphate + propanoyl-CoA <=> CoA + propanoyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50681", "l": "H2O + N-terminal L-glutaminyl-[protein] => N-terminal L-glutamyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27892", "l": "phosphate + uridine => 3'-UMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24059", "l": "a myo-inositol phosphate + H2O <=> myo-inositol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389491", "l": "Two NPFF receptors can bind neuropeptide FF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40310", "l": "A + decanedioyl-CoA <=> (2E)-decenedioyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0016699", "l": "oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor"}, {"i": "EC:1.12.7.-", "l": "\"With an iron-sulfur protein as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22318", "l": "13-(beta-D-glucosyloxy)docosanoate + H(+) + UDP => 13-hydroxydocosanoate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18565", "l": "19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine = 9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.3.1.161", "l": "\"Lovastatin nonaketide synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47114", "l": "glycochenodeoxycholate + H2O => chenodeoxycholate + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693593", "l": "D-loop extension by DNA polymerases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42248", "l": "butanoyl-CoA + H(+) + malonyl-[ACP] = 3-oxohexanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22465", "l": "L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57111", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950740", "l": "CANX dissociates from IL12A:EBI3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391158", "l": "SIRP alpha binds CD47 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30937", "l": "beta-D-ribosylnicotinate + phosphate => H2O + nicotinate beta-D-ribonucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28303", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + germacrene C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373707", "l": "Netrin-1 induced DCC clustering (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374686", "l": "L1 interaction with Integrins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071633", "l": "dihydroceramidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13757", "l": "(Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose = (Z)-desulfoglucotropeolin + UDP"}, {"i": "EC:2.4.1.195", "l": "\"N-hydroxythioamide S-beta-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22599", "l": "cephalosporin C + H2O <=> acetate + deacetylcephalosporin C + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814153", "l": "ADO oxidises 2AET to HTAU (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28266", "l": "(2E,6E)-farnesyl diphosphate = (S)-beta-bisabolene + diphosphate"}, {"i": "EC:4.2.3.55", "l": "\"(S)-beta-bisabolene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018474", "l": "2-carboxybenzaldehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672817", "l": "Active MTORC1 binds the ULK1 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678694", "l": "Heparanase 2 (HPSE2) cleaves heparan sulfate from its proteoglycan (plasma membrane) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19433", "l": "ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+)"}, {"i": "EC:2.7.1.12", "l": "\"Gluconokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34436", "l": "4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine => 4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21649", "l": "H(+) + prephenate => 3-phenylpyruvate + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37144", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50442", "l": "prostaglandin D1 => prostaglandin H1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57459", "l": "E-sinapate + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-trans-sinapate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42454", "l": "H2O + kynurenate => 4-(2-aminophenyl)-2,4-dioxobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12245", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + FADH2 => (6S)-5,6,7,8-tetrahydrofolate + dTMP + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696547", "l": "STAMBPL1 is a deubiquitinase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48460", "l": "1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = 2-octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033240", "l": "PEX5L binds PEX7:Cargo protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68637", "l": "CDC6 protein is synthesized under the control of E2F transcription factors (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33962", "l": "2-oxoglutarate + neomycin C <=> 6'''-deamino-6'''-oxoneomycin C + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10754", "l": "[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n H(+) + n phosphate => [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n ATP + n D-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112690", "l": "PTPN11 binds CBL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50825", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 => 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938121", "l": "SERPINB13 binds CTSK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27678", "l": "ATP + dCDP = ADP + dCTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102004", "l": "2-octaprenyl-6-hydroxyphenol methylase activity"}, {"i": "RHEA:27770", "l": "3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}, {"i": "MetaCyc:2-OCTAPRENYL-6-OHPHENOL-METHY-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56220", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64753", "l": "3-sulfanylpentan-1-ol-L-cysteine + H2O => 3-sulfanyl-1-pentanol + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45117", "l": "(4R)-ipsdienol + NADP(+) => H(+) + ipsdienone + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13874", "l": "(+)-copalyl diphosphate => abieta-7,13-diene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44539", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33156", "l": "a 1-acyl-sn-glycero-3-phosphate + H2O => a 1-acyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33697", "l": "3-oxoeicosasphinganine + H(+) + NADPH => C20 sphinganine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26330", "l": "(S)-8-amino-7-oxononanoate + L-lysine => (7R,8S)-7,8-diammoniononanoate + (S)-2-amino-6-oxohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61772", "l": "rebaudioside E + UDP-alpha-D-glucose = H(+) + rebaudioside D + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199298", "l": "AKT phosphorylates CREB1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061660", "l": "Atg12 ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58243", "l": "H2O + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] <=> ADP-D-ribose + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-982765", "l": "Growth hormone forms dimers and oligomers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216043", "l": "Collagen type II binds integrin alpha10beta1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805122", "l": "AURKB binds TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687465", "l": "MRN complex binds RBBP8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "69.997272734060871", "identifiers": [{"i": "GO:0015295", "l": "solute:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18715", "l": "L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-D-gluco-hex-4-ulose => 2-oxoglutarate + UDP-N-acetylbacillosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63988", "l": "2-thiocytidine + ATP = 2-thiocytidine 5'-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30580", "l": "H2O + O-phospho-L-threonine => L-threonine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20918", "l": "hydrogen sulfide + L-cysteate => L-cysteine + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37975", "l": "H(+) + homogentisate + phytyl diphosphate = 2-methyl-6-phytyl-1,4-benzene-1,4-diol + CO2 + diphosphate"}, {"i": "EC:2.5.1.115", "l": "\"Homogentisate phytyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61139", "l": "(2R,3R)-dihydroquercetin + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + quercetin + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6813749", "l": "ALDH1A1 oxidises GA to DGA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "62.855849573674305", "identifiers": [{"i": "GO:0004930", "l": "G protein-coupled receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028724", "l": "AMOT proteins bind YAP1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-164840", "l": "ADP and Pi bind to ATPase (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382054", "l": "PDGF binds to extracellular matrix proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24985", "l": "(1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16502", "l": "H2O + sn-glycero-3-phospho-1D-myo-inositol => H(+) + myo-inositol + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000327", "l": "PLK1 phosphorylates BORA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605595", "l": "Hexosaminidase A cleaves GalNAc from GM2 to form GM3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31790", "l": "H2O + tuberculosinyl diphosphate <=> (13R)-edaxadiene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28660", "l": "beta-lactose + H2O => beta-D-galactose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38113", "l": "H(+) + L-glyceraldehyde + NADPH => glycerol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445072", "l": "Interaction of PAK1 with Rac1-GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1247922", "l": "GGCT transforms gGluCys to OPRO (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034941", "l": "pyrrole-2-carboxylate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2106614", "l": "Duplex miRNA is loaded into Argonaute (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209960", "l": "Diiodinated tyrosine can be deiodinated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432946", "l": "PARVB/Affixin interacts with alpha PIX (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036285", "l": "Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10787", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(36)-[histone H3] + O2 <=> CO2 + formaldehyde + L-lysyl(36)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3857336", "l": "CEBPB homodimerization (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30344", "l": "FAD + H(+) + succinate => FADH2 + fumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602466", "l": "Activation of MT-MMPs by FURIN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-156682", "l": "PLK1 phosphorylates NUDC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450387", "l": "HuR binds the CRM1 nuclear export machinery (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209177", "l": "LGS:ARM complex transports from the cytosol to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.12.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42304", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22502", "l": "(E)-feruloylacetyl-CoA + CO2 + CoA => (E)-feruloyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50441", "l": "prostaglandin H1 => prostaglandin D1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418868", "l": "Recruitment of Src and Fyn to DCC:FADK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23262", "l": "15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH => (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29718", "l": "2-hydroxyethane-1-sulfonate + FMNH2 + O2 <=> FMN + glycolaldehyde + 2 H(+) + H2O + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730841", "l": "Phosphorylation and activation of VAV (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62559", "l": "3,4-dihydroxyphenylacetate + H(+) <=> 4-methylcatechol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875568", "l": "RAPGEF1 activates RAP1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420233", "l": "VIP receptors bind VIP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22930", "l": "4-aminobutanoyl-CoA + acetate => 4-acetamidobutanoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14919", "l": "4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 3 O2 + obtusifoliol + 3 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54456", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204861", "l": "Interaction of Tie2 and Shc1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19448", "l": "2,3-dihydroxyindole + O2 <=> anthranilate + CO2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47626", "l": "1-pyrroline-2-carboxylate + H2O => cis-3-hydroxy-L-proline"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004915", "l": "interleukin-6 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49568", "l": "2-glutathionyl-2-methylbut-3-en-1-ol = (3R)-3,4-epoxy-3-methylbut-1-ene + glutathione"}, {"i": "EC:4.4.1.34", "l": "\"Isoprene-epoxide--glutathione S-transferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902944", "l": "aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691131", "l": "CANDI binds CUL1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51231", "l": "17alpha-ethynylestradiol + 3'-phosphoadenylyl sulfate <=> 17alpha-ethynylestradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41880", "l": "(2E)-dodecenoyl-[ACP] + H(+) + NADPH = dodecanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46584", "l": "1alpha-hydroxyvitamin D2 + O2 + reduced [NADPH--hemoprotein reductase] = 1alpha,25-dihydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55947", "l": "2-chloroethanol + 2 [Fe(III)cytochrome c] <=> 2 [Fe(II)cytochrome c] + chloroacetaldehyde + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:1901375", "l": "acetate ester transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948775", "l": "MKRN1 polyubiquitinates PTEN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950362", "l": "EBI3:CANX binds IL12A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15703", "l": "A + all-trans-lycopene + 2 H2O => AH2 + all-trans-neurosporene + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5221061", "l": "TDG excises 5-carboxylcytosine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54913", "l": "11-cis-retinol + NADP(+) => 11-cis-retinal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418553", "l": "cAMP degradation by Phosphodiesterases (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33420", "l": "[(1R)-2,2,3-trimethyl-2-oxocyclopent-3-en-1-yl]acetate + ATP + CoA => [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876948", "l": "SRC phosphorylates InlA-bound CDH1 and CTNNB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37914", "l": "(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35756", "l": "NAD(+) + UDP-alpha-D-glucose => H(+) + NADH + UDP-3-oxo-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22271", "l": "ATP + streptomycin <=> ADP + H(+) + streptomycin 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043909", "l": "N-acetylcitrulline deacetylase activity"}, {"i": "RHEA:61092", "l": "H2O + N(2)-acetyl-L-citrulline = acetate + L-citrulline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40248", "l": "H2O + rhodomycin D => 10-carboxy-13-deoxycarminomycin + H(+) + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44897", "l": "a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose => H(+) + N-(2-hydroxyacyl)-beta-D-galactosyl-sphing-4-enine + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26183", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O <=> 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52624", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-glutamate = [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30252", "l": "2 a ubiquinol + n H(+)(in) + O2 => 2 a ubiquinone + n H(+)(out) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2467775", "l": "Autocleavage of ESPL1 (Separase) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51885", "l": "L-proline betaine => D-proline betaine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004326", "l": "tetrahydrofolylpolyglutamate synthase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0140034", "l": "methylation-dependent protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9663511", "l": "BIL binds GSTA1, FABP1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64098", "l": "2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + H(+) + holo-[ACP] => 3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23527", "l": "1-O-(trans-cinnamoyl)-beta-D-glucose + an alcohol <=> an alkyl cinnamate + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59863", "l": "3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->6)-N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0005388", "l": "P-type calcium transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17671", "l": "3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+) => 3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201787", "l": "PPP3 complex dephosphorylates DARPP-32 on Thr34 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709406", "l": "CO binds to Cytochrome c oxidase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28124", "l": "ADP + di-trans,octa-cis-undecaprenyl phosphate + H(+) => ATP + di-trans,octa-cis-undecaprenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64818", "l": "5-aminolevulinate(out) => 5-aminolevulinate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17601", "l": "ATP + D-ribulose = ADP + D-ribulose 5-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417898", "l": "P2Y4 receptor can bind to UTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050047", "l": "leucine 2,3-aminomutase activity"}, {"i": "RHEA:10284", "l": "L-leucine = (3R)-beta-leucine"}, {"i": "EC:5.4.3.7", "l": "\"Leucine 2,3-aminomutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112703", "l": "PTPN11 is phosphorylated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63364", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + O2 = (S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-1,3-oxazole-[protein] + H2O2"}, {"i": "EC:1.3.3.16", "l": "\"Oxazoline dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977375", "l": "CR1 binds C3bBb/C4bC2a (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11646", "l": "an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH => a (2R,3R)-flavan-3-ol + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12062", "l": "3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + 6 CO2 + 7 CoA + H2O => acetyl-CoA + 5 H(+) + 6 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63400", "l": "Fe(II)-hydroxyheme i = Fe(II)-heme a + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-217255", "l": "FMO1:FAD N-oxidises TAM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734687", "l": "ORC6 is phosphorylated on T195 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13149", "l": "A + H(+) + NADPH = AH2 + NADP(+)"}, {"i": "EC:1.6.99.1", "l": "\"NADPH dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071713", "l": "para-aminobenzoyl-glutamate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350441", "l": "FLW:MYPT-75D complex dephosphorylates SQH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983266", "l": "Kinesins bind microtubules (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-166214", "l": "FA anion flip-flops to the opposite surface (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10702", "l": "limonene-1,2-diol => H2O + limonene 1,2-epoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27351", "l": "arseno-mycothiol + H2O => arsenate + mycothiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12745", "l": "a 1,4-lactone + H2O = a 4-hydroxyacid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41633", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + L-serine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phospho-L-serine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419389", "l": "LPA-binding receptors bind LPA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864698", "l": "KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60333", "l": "L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158399", "l": "kallikrein binds SERPING1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35110", "l": "3-nitrotyramine + H2O + O2 <=> 4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191784", "l": "snRNA Cap hypermethylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61412", "l": "ATP + N-(D-erythrulosyl)-cadaverine = ADP + H(+) + N-(3-O-phospho-D-erythrulosyl)-cadaverine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004506", "l": "squalene monooxygenase activity"}, {"i": "RHEA:25282", "l": "O2 + reduced [NADPH--hemoprotein reductase] + squalene = (S)-2,3-epoxysqualene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.17", "l": "\"Squalene monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607745", "l": "1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12834", "l": "an N-acyl-D-glutamate + H2O => a carboxylate + D-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41815", "l": "(2E)-butenoyl-[ACP] + H(+) + NADPH <=> butanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48598", "l": "decanoate + decanoylglycerol + H(+) => 1,2-didecanoylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63166", "l": "taurine + tricosanoate => H2O + N-tricosanoyl-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034875", "l": "NTRK3 phosphorylates SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-870538", "l": "TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018734", "l": "butyrolactone hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849085", "l": "ARHGAP35 binds RHOA:GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74885", "l": "GUCYs converts GTP to cGMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755545", "l": "Defective DHDDS does not elongate E,E-FPP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50064", "l": "ATP + H2O + taurochenodeoxycholate(in) = ADP + H(+) + phosphate + taurochenodeoxycholate(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000246", "l": "delta24(24-1) sterol reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011241", "l": "SRC phosphorylates ROBO3.1 in response to NTN1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004452", "l": "isopentenyl-diphosphate delta-isomerase activity"}, {"i": "RHEA:23284", "l": "isopentenyl diphosphate = dimethylallyl diphosphate"}, {"i": "EC:5.3.3.2", "l": "\"Isopentenyl-diphosphate Delta-isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.37"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44479", "l": "1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001073", "l": "cyclodextrin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31501", "l": "a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP => a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102386", "l": "phenylacetaldehyde reductase activity"}, {"i": "MetaCyc:RXN-13536"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985943", "l": "p-Y701-STAT1 dimerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047845", "l": "deoxylimonate A-ring-lactonase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18049", "l": "2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde"}, {"i": "EC:2.6.1.11", "l": "\"Acetylornithine transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18220", "l": "2-oxoglutarate + an alkane-alpha,omega-diamine <=> an omega-aminoaldehyde + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417842", "l": "P2Y10 receptor can bind to LPA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706308", "l": "Active FLT3 binds to GRB10 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40583", "l": "H2O + hexanedioyl-CoA = CoA + H(+) + hexanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928645", "l": "EPHB:NMDAR binds TIAM1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034598", "l": "phosphothreonine lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56307", "l": "ATP + H2O + rifampicin <=> 21-phosphorifampicin + AMP + 2 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37178", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5333671", "l": "CLCAs self cleave (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351901", "l": "Caspase-mediated cleavage of MST3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429683", "l": "CERT:ceramide [ER] => ceramide [Golgi] + CERT [ER] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351455", "l": "Phosphorylation of NBS1 by ATM (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950183", "l": "IL12B binds IL23A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44655", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a 1-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10818", "l": "L-fucose + methyl beta-D-galactoside => H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51270", "l": "4'-O-methylnorbelladine + H(+) + S-adenosyl-L-homocysteine => norbelladine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15195", "l": "2'-deoxyguanosine + H(+) + triphosphate => dGTP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694780", "l": "Spike trimer translocates to ERGIC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55189", "l": "5-methyluridine(54) in tRNA + ATP + hydrogen sulfide => 5-methyl-2-thiouridine(54) in tRNA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944214", "l": "Association of procollagen type I (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.12"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34362", "l": "a 1,2-diacylglycerol + H2O <=> a 2-acylglycerol + a carboxylate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12832", "l": "(2S,3S)-3-methyl-L-aspartate <=> mesaconate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10619", "l": "(2R,3S)-catechin + H2O + NADP(+) <=> (2R,3S,4S)-leucocyanidin + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25176", "l": "H2O + N(omega)-methyl-L-arginine <=> L-citrulline + methylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48565", "l": "9-ribosyl-trans-zeatin 5'-phosphate + H2O => D-ribose 5-phosphate + trans-zeatin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39684", "l": "3-oxo-(11Z)-octadecenoyl-CoA + H(+) + NADPH => (R)-3-hydroxy-(11Z)-octadecenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140314", "l": "calcium ion sequestering activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.10", "l": "\"Acrosin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24313", "l": "L-lysyl-[cytochrome c] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710254", "l": "GSDME oligomerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10671", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) <=> 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2730872", "l": "Activation of Calcineurin (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52013", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102617", "l": "oryzalexin C synthase (oryzalexin B dependent) activity"}, {"i": "MetaCyc:RXN-15465"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38227", "l": "(9Z)-octadecenoyl-CoA + hexadecan-1-ol = CoA + hexadecanyl (9Z)-octadecenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39698", "l": "3-oxo-(13Z)-eicosenoyl-CoA + H(+) + NADPH <=> (R)-3-hydroxy-(13Z)-eicosenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36468", "l": "H2O + L-alanylglycine => glycine + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56929", "l": "abieta-7,13-dien-18-al + O2 + reduced [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20652", "l": "23,24-dihydrocucurbitacin B + NADP(+) <=> cucurbitacin B + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40506", "l": "N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine <=> N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27939", "l": "(3R)-3-hydroxy-D-aspartate => glycine + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784765", "l": "p-Y705-STAT3 dimerizes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249378", "l": "STING recruits TBK1 and STAT6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26420", "l": "(2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal => (3R)-3-hydroxy-8'-apo-beta-carotenal + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213239", "l": "Formation of MHC II alpha beta heterodimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1461982", "l": "Alpha-defensin dimers multimerize to form a pore complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213236", "l": "TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050573", "l": "dTDP-4-dehydro-6-deoxyglucose reductase activity"}, {"i": "MetaCyc:1.1.1.266-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12691", "l": "H(+) + mycothione + NADH => 2 mycothiol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44018", "l": "2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH => 2,6,10,14-tetramethylpentadecanal + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730842", "l": "PI3K associates with phosphorylated GAB2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36263", "l": "hydroxyurea + O-acetyl-L-serine = acetate + H(+) + O-ureido-L-serine"}, {"i": "EC:2.6.99.3", "l": "\"O-ureido-L-serine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56700", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 = 3-[(Z)-2-isocyanoethenyl]-1H-indole + 2 CO2 + H2O + succinate"}, {"i": "EC:1.14.20.11", "l": "\"3-((Z)-2-isocyanoethenyl)-1H-indole synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26196", "l": "(S)-malate + ATP + CoA <=> (S)-malyl-CoA + ADP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.131", "l": "\"Carotenoid 1,2-hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449077", "l": "Interleukin-16 is secreted (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35063", "l": "H2O + pyrazinamide = NH4(+) + pyrazine-2-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47511", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADH <=> isolithocholate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37314", "l": "ATP + glycyl-L-glutamine(out) + H2O <=> ADP + glycyl-L-glutamine(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21564", "l": "acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA"}, {"i": "EC:2.3.1.16", "l": "\"Acetyl-CoA C-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389523", "l": "BTLA interacts with HVEM (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52017", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38465", "l": "a 1,2-diacyl-sn-glycerol + CoA => a 1-acyl-sn-glycerol + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909720", "l": "IFN alpha/beta binds to IFNAR2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20103", "l": "AMP + diphosphate + S-(long-chain fatty acyl)-L-cysteinyl-[protein] => a long-chain fatty acid + ATP + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250264", "l": "TXNIP binds reduced thioredoxin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24724", "l": "H2O + L-methionyl(44)-(R)-S-oxide-[F-actin] + NADP(+) => H(+) + L-methionyl(44)-[F-actin] + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23362", "l": "alpha-D-glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP => L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23581", "l": "prostaglandin H2 => prostaglandin I2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35093", "l": "2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine => anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685655", "l": "CTSL bind CTSL inhibitors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50070", "l": "ADP + glycoursodeoxycholate(out) + H(+) + phosphate => ATP + glycoursodeoxycholate(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34974", "l": "Fe(3+)(in) <=> Fe(3+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5340226", "l": "CYGB dioxygenates NO (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58729", "l": "adenosine in rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.212", "l": "\"Endo-(1->4)-fucoidanase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32624", "l": "L-threo-tetrahydrobiopterin + 2 NADP(+) => 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44890", "l": "1-O-alkyl-sn-glycero-3-phosphate + a fatty acid + H(+) => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59891", "l": "4-chloro-L-lysine + AH2 + O2 <=> A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22040", "l": "H2O + N-formyl-L-aspartate = formate + L-aspartate"}, {"i": "EC:3.5.1.8", "l": "\"Formylaspartate deformylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17394", "l": "3-maleylpyruvate => 3-fumarylpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9658253", "l": "RAS:GTP binds PI3K (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58833", "l": "24-methylenecycloartanol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250280", "l": "ROS oxidize thioredoxin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28747", "l": "NH4(+)(in) = NH4(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20099", "l": "2-dehydro-3-deoxy-D-gluconate + H2O => D-mannonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.11", "l": "\"Serine--tRNA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000832", "l": "inositol hexakisphosphate 5-kinase activity"}, {"i": "KEGG.REACTION:R09087"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433451", "l": "JAK2 binds to p-KIT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56826", "l": "A + cyclooctatin + H2O => AH2 + cyclooctat-9-ene-5,7-diol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12631", "l": "(6S)-6-hydroxyhyoscyamine + CO2 + succinate => 2-oxoglutarate + L-hyoscyamine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8949580", "l": "F1Fo ATP synthase dimerizes (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605724", "l": "Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434637", "l": "PI(3,4,5)P3 binds VAV1,2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21194", "l": "D-galactosyl-N-acetyl-beta-D-galactosamine + L-serine => D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19798", "l": "1D-myo-inositol 1,4,5-trisphosphate + H2O => 1D-myo-inositol 1,4-bisphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399938", "l": "Activation of Rac1 by FARP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373887", "l": "lactate + H+ [extracellular] <=> lactate + H+ [cytosol] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327746", "l": "FN1 aggregation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9007539", "l": "CHEK1 phosphorylates E2F6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34692", "l": "(R)-lactoyl-CoA => acryloyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27561", "l": "all-trans-hexaprenyl diphosphate + 3 diphosphate => (2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433418", "l": "Phosphorylation of JAK2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102584", "l": "cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-15330"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432527", "l": "Nuclear PP2A dephosphorylates phosphorylated PER (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45011", "l": "H2O + N-(octadecanoyl)-sphinganine <=> octadecanoate + sphinganine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033569", "l": "lactoferrin transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37757", "l": "1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672978", "l": "RAF phosphorylates MAP2K dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693347", "l": "CRYM reduces P2C to PPCA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13412", "l": "7-aminomethyl-7-carbaguanine + 2 NADP(+) <=> 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.57"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4167511", "l": "HLCS biotinylates ACACB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031874", "l": "type 3 proteinase activated receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110237", "l": "MUTYH mediated recognition and binding of an adenine opposite to an 8-oxoguanine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57325", "l": "acetyl-CoA + N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein] => CoA + H(+) + N-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50822", "l": "H(+) + NADPH + testosterone => 17beta-hydroxy-5alpha-androstan-3-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9615249", "l": "ARBs bind AGRT1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047549", "l": "2-nitrophenol 2-monooxygenase activity"}, {"i": "MetaCyc:2-NITROPHENOL-2-MONOOXYGENASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36637", "l": "7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine => 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693536", "l": "ATM phosphorylates MDC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607722", "l": "Active NIK phosphorylates IKKA dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675431", "l": "PP2A dephosphorylates RAF1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "79.238648346243679", "identifiers": [{"i": "GO:0061134", "l": "peptidase regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186785", "l": "PDGF-AA clevage by Furin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25572", "l": "geranylgeranyl diphosphate + 2 H2O = diphosphate + sclareol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4608855", "l": "PRICKLE1 is degraded by the proteasome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.9.-", "l": "\"Phosphotransferases with paired acceptors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170810", "l": "nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46928", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol = a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol"}, {"i": "EC:5.1.3.34", "l": "\"Monoglucosyldiacylglycerol epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874200", "l": "CREB3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62050", "l": "an N-aryl-1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => an N-aryl-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009309", "l": "RUNX2 binds STUB1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008899", "l": "homoserine O-succinyltransferase activity"}, {"i": "MetaCyc:HOMSUCTRAN-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41404", "l": "(R)-2-methylpyrrolidine + NADP(+) = 2-methyl-1-pyrroline + H(+) + NADPH"}, {"i": "EC:1.5.1.48", "l": "\"2-methyl-1-pyrroline reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689861", "l": "Recruitment of XPA and release of CAK  (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730862", "l": "Autophosphorylation of LYN kinase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610733", "l": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51952", "l": "(E)-2-methylpropanal oxime + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2-methylpropanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38016", "l": "delta-tocotrienol => 6-geranylgeranyl-2-methylbenzene-1,4-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47156", "l": "7alpha,25-dihydroxycholesterol + NAD(+) = 7alpha,25-dihydroxy-4-cholesten-3-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047951", "l": "glutathione thiolesterase activity"}, {"i": "RHEA:22708", "l": "H2O + S-acylglutathione = a carboxylate + glutathione + H(+)"}, {"i": "EC:3.1.2.7", "l": "\"Glutathione thiolesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641205", "l": "RSPO:LGR binds ZNRF3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58391", "l": "4-aminobenzoate + all-trans-hexaprenyl diphosphate <=> 4-amino-3-all-trans-hexaprenylbenzoate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1912379", "l": "Transport of fringe-modified NOTCH to plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14176", "l": "dimethylallyl diphosphate + L-tryptophan <=> 4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102747", "l": "chlorophyllide-a:geranyl-geranyl diphosphate geranyl-geranyl transferase activity"}, {"i": "MetaCyc:RXN-7663"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804527", "l": "INTL1 binds bacterial glycans (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19240", "l": "4-carboxymethyl-4-methylbut-2-en-1,4-olide <=> 4-carboxymethyl-3-methylbut-2-en-1,4-olide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2731141", "l": "Syndecan-1 binds fibronectin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8873946", "l": "OTUD3 deubiquitinates PTEN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29939", "l": "H(+)(in) + phosphate(in) = H(+)(out) + phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139918", "l": "Phosphorylation of BIM by JNK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22046", "l": "ADP + 2 H(+)(out) + K(+)(in) + phosphate => ATP + H(+)(in) + H2O + K(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852306", "l": "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31278", "l": "(S)-3-hydroxy-2-methylpropanoate + NAD(+) <=> (S)-methylmalonate semialdehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37863", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA = 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0035381", "l": "ATP-gated ion channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29848", "l": "(2E)-tetradecenoyl-CoA => (3Z)-tetradecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57709", "l": "(E)-coniferaldehyde + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-4-trans-coniferyl aldehyde + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033916", "l": "beta-agarase activity"}, {"i": "EC:3.2.1.81", "l": "\"Beta-agarase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30050", "l": "chloroacetaldehyde + H2O + NAD(+) <=> chloroacetate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800315", "l": "MST1 binds MST1R (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.20", "l": "\"Succinyl-CoA--D-citramalate CoA-transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452338", "l": "Expression of TDGF1 (CRIPTO) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56692", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 = 4-[(E)-2-isocyanoethenyl]phenol + 2 CO2 + H2O + succinate"}, {"i": "EC:1.14.20.10", "l": "\"Tyrosine isonitrile desaturase/decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858489", "l": "ppDVL binds DAAM1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18594", "l": "sphinganine 1-phosphate => hexadecanal + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49198", "l": "25-hydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin] => 2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097108", "l": "hedgehog family protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28698", "l": "hydrogencarbonate(in) <=> hydrogencarbonate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20545", "l": "H(+) + L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP(+)"}, {"i": "EC:1.14.13.9", "l": "\"Kynurenine 3-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29058", "l": "a ubiquinone + 2 H(+)(in) + H2 <=> a ubiquinol + 2 H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48849", "l": "(9Z,12Z)-octadecadienoate + O2 => 13-hydroperoxy-(9Z,11E)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62185", "l": "peregrinol diphosphate => diphosphate + labd-13(16),14-diene-9-ol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005212", "l": "structural constituent of eye lens"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30297", "l": "GDP + H(+) + phosphoenolpyruvate => GTP + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35759", "l": "8-O-methylsterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = aflatoxin B1 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]"}, {"i": "RHEA:35763", "l": "8-O-methyldihydrosterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = aflatoxin B2 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.117", "l": "\"Aflatoxin B synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.6", "l": "\"CC-preferring endodeoxyribonuclease\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034785", "l": "salicylate 5-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164617", "l": "Elongation of Extended Telomeric Chromosome End (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869580", "l": "DEK binds TFAP2A homodimers (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.n2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40957", "l": "ADP + CO2 + isopentenyl phosphate + phosphate => (R)-5-phosphomevalonate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11453", "l": "7-deoxyloganin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + loganin + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392513", "l": "Rap1 signal termination by Rap1GAPs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805785", "l": "AKT phosphorylates PHF20 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102265", "l": "tRNA-dihydrouridine47 synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428918", "l": "Dissociation of the TP:G13 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44226", "l": "16-hydroxyhexadecanoyl-CoA + AMP + diphosphate => 16-hydroxyhexadecanoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58843", "l": "cholesterol sulfate + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-hydroxycholesterol 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0016864", "l": "intramolecular oxidoreductase activity, transposing S-S bonds"}, {"i": "EC:5.3.4.-", "l": "\"Transposing S-S bonds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451283", "l": "kainate receptor binds glutamate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2032775", "l": "YAP1 binds TEAD1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018594", "l": "MECP2 binds LBR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380272", "l": "Plk1-mediated phosphorylation of Nlp (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45234", "l": "a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) => a (2E,4Z)-dienoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417829", "l": "P2RY12 binds ADP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51801", "l": "deoxyadlupulone + dimethylallyl diphosphate => adlupulone + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10116", "l": "6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41339", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624494", "l": "RAF1 binds p21 RAS:GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2090079", "l": "GLB1 hydrolyses linker chain(2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66737", "l": "ATP + beta-citrylglutamate(in) + H2O => ADP + beta-citrylglutamate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672978", "l": "RAF phosphorylates MAP2K dimer (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.92", "l": "\"Peptidoglycan beta-N-acetylmuramidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55522", "l": "3 diphosphate + nerylneryl diphosphate => dimethylallyl diphosphate + 3 isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670416", "l": "Recruitment of STATs by KIT mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24671", "l": "H2O + hypoxanthine + NAD(+) => H(+) + NADH + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351341", "l": "Exocytosis of Proactivator polypeptide (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658430", "l": "NF1 is degraded by the proteasome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110311", "l": "POLZ extends translesion synthesis (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28624", "l": "(-)-vetispiradiene + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + solavetivol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420688", "l": "GABAB heterodimeric receptor binds GABA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805785", "l": "AKT phosphorylates PHF20 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64077", "l": "3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 => 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32900", "l": "1,8-cineole + O2 + reduced [flavodoxin] => 2-endo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062203", "l": "Viteagnusin D synthase activity"}, {"i": "RHEA:62180", "l": "H2O + peregrinol diphosphate = diphosphate + viteagnusin D"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419428", "l": "S1PR2-5 bind S1P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016524", "l": "latrotoxin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805205", "l": "GPR35 binds kynurenic acid (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451347", "l": "Activation of JNK by DSCAM (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48158", "l": "ganglioside GT1b (d18:1(4E)) + N-acetylneuraminate => ganglioside GQ1b (d18:1(4E)) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433418", "l": "Phosphorylation of JAK2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10314", "l": "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) => H(+) + NADH + O2 + terephthalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34077", "l": "a 1-acyl-sn-glycero-3-phosphate + phosphate => an acyl phosphate + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30418", "l": "H(+) + 2 NADPH + O2 + octadecanal <=> formate + H2O + heptadecane + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788623", "l": "p-Y-STATs translocate to nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53436", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033478", "l": "USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40478", "l": "1,2,3-tributanoylglycerol + H2O <=> butanoate + dibutanoylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168638", "l": "Activated IKK phosphorylates I-kappaB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46567", "l": "acetyl-CoA + apo-[ACP] <=> acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23940", "l": "D-gluconate + NAD(+) = 5-dehydro-D-gluconate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5591052", "l": "PROCR binds Protein C (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22598", "l": "acetate + deacetylcephalosporin C + H(+) => cephalosporin C + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429732", "l": "multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58092", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59230", "l": "6-sulfo-beta-D-quinovose => 6-sulfo-alpha-D-quinovose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50402", "l": "CoA + S-octanoyl-L-cysteinyl-[PqsC protein] => L-cysteinyl-[PqsC protein] + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37657", "l": "1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10957", "l": "(E)-cinnamate + H(+) + NADPH + O2 => H2O + NADP(+) + trans-2-coumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27391", "l": "pyruvate + salicylaldehyde => (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.9", "l": "\"Enteropeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32476", "l": "glycine + 3 S-adenosyl-L-methionine => glycine betaine + 3 H(+) + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218822", "l": "CRK binds BCAR1 and or PXN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43134", "l": "H(+) + N(2)-dimethylguanosine(10) in tRNA + S-adenosyl-L-homocysteine => N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0031593", "l": "polyubiquitin modification-dependent protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11139", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112429", "l": "Formation of FACT complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58752", "l": "1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51756", "l": "a 2-acyl-4-prenylphloroglucinol + dimethylallyl diphosphate = a 2-acyl-4,6-diprenylphloroglucinol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50909", "l": "a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 => A + a 3-demethylubiquinol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20410", "l": "alpha-D-glucose 1-phosphate + riboflavin => D-glucose + FMN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-429860", "l": "DCP1-DCP2 complex decaps mRNA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626228", "l": "The distal appendage proteins recruit TTBK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605624", "l": "Beta-galactosidase hydrolyses GM1 to GM2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56735", "l": "4,4-dihydroxy-all-trans-beta-carotene <=> echinenone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655702", "l": "Defective SLC3A1 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.133"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31274", "l": "1-hydroxy-2-naphthoate + 2 H(+) + NADH + O2 <=> CO2 + H2O + NAD(+) + naphthalene-1,2-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28351", "l": "UDP-beta-L-arabinofuranose => UDP-beta-L-arabinopyranose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008925", "l": "maltose O-acetyltransferase activity"}, {"i": "MetaCyc:MALTACETYLTRAN-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28928", "l": "3,4,5-trihydroxybenzoate + O2 => (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.15"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54138", "l": "5-methylcytidine(48) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine => cytidine(48) in tRNA precursor + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944219", "l": "Association of procollagen type XVI (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-937050", "l": "Pellino ubiquitinates hp-IRAK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10014", "l": "6-hydroxypseudooxynicotine + H2O2 => (R)-6-hydroxynicotine + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36059", "l": "A + dihydrourocanate = AH2 + urocanate"}, {"i": "EC:1.3.99.33", "l": "\"Urocanate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55982", "l": "an (R)-2-alkyl-3-oxoalkanoate + 2 CoA + H(+) => a 1,2-saturated acyl-CoA + an acyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33466", "l": "episterol + H(+) + NADPH + O2 <=> ergosta-5,7,24(28)-trien-3beta-ol + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031219", "l": "levanase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65020", "l": "L-ornithine + succinyl-CoA = CoA + H(+) + N(2)-succinyl-L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174224", "l": "Dissociation of Cdc20 from APC/C complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23058", "l": "cyanamide + H2O => urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972965", "l": "POU5F1 (OCT4), SOX2, NANOG bind the TSC22D1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033431", "l": "CGA codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866269", "l": "ARRB bind GPCRs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19488", "l": "sphing-4-enine + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1<->1)-sphing-4-enine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034532", "l": "2-hydroxy-7-hydroxymethylchromene-2-carboxylate isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17877", "l": "a catechol + S-adenosyl-L-methionine = a guaiacol + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.6", "l": "\"Catechol O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679028", "l": "JAK3 binds JAK3 inhibitors (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8862280", "l": "FCHo proteins bind nascent clathrin-coated pit (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54533", "l": "H2O + N-(4-oxoglutaryl)-L-cysteinylglycine => 2-oxoglutarate + L-cysteinylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196026", "l": "Dab2 is recruited to the junctional plaques (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53331", "l": "H2O + UDP-2,3-diacyl-alpha-D-glucosamine <=> 2,3-diacyl-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2993802", "l": "HLCS biotinylates PC:Mn2+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56917", "l": "3beta-hydroxy-5alpha-androstan-17-one + NADP(+) => 5alpha-androstan-3,17-dione + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65011", "l": "ATP + decanoate + H(+) <=> decanoyl-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31515", "l": "4'-apo-beta-carotenal + H2O + NAD(+) = 2 H(+) + NADH + neurosporaxanthin"}, {"i": "EC:1.2.1.82", "l": "\"Beta-apo-4'-carotenal oxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63418", "l": "2-chloro-6-hydroxy-1,4-benzoquinone + chloride + FAD + 2 H(+) + H2O => 2,6-dichlorohydroquinone + FADH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202307", "l": "Change of PKC theta conformation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48910", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP => L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62151", "l": "dGTP + dTMP <=> dGDP + dTDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23807", "l": "N-acetyl-alpha-D-glucosamine 1-phosphate <=> N-acetyl-D-glucosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030767", "l": "3-hydroxyanthranilate 4-C-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111915", "l": "CAMK4 autophosphorylates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58651", "l": "rifamycin SV hemiaminal <=> H(+) + rifamycin SV ortho-naphthoquinone carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25825", "l": "H2O + O2 + spermine => H2O2 + N-(3-aminopropyl)-4-aminobutanal + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001877", "l": "lipoarabinomannan immune receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-933533", "l": "Dimerization of p-IRF7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019811", "l": "cocaine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682983", "l": "ATM phosphorylates WHSC1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53798", "l": "deoxycholate + ursodeoxycholoyl-CoA => deoxycholoyl-CoA + ursodeoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55099", "l": "(3S)-3-hydroxypentanoyl-CoA + H2O <=> (3S)-3-hydroxypentanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008934", "l": "inositol monophosphate 1-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043295", "l": "glutathione binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10526", "l": "CO2 + succinate semialdehyde => 2-oxoglutarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-114683", "l": "Phosphorylation of Platelet Sec-1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46729", "l": "(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2 => (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.34", "l": "\"Monoprenyl isoflavone epoxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798474", "l": "S100A8:S100A9 binds Zn2+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31598", "l": "(Z)-2-methylureidoacrylate + H2O <=> (Z)-2-methylaminoacrylate + carbamate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57115", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031715", "l": "C5L2 anaphylatoxin chemotactic receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23900", "l": "cis-stilbene oxide + H2O = (1R,2R)-hydrobenzoin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25913", "l": "A + H2O + quinolin-5-ol => 5-hydroxyquinolin-2(1H)-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33071", "l": "D-glucose 6-phosphate = 2-deoxy-L-scyllo-inosose + phosphate"}, {"i": "EC:4.2.3.124", "l": "\"2-deoxy-scyllo-inosose synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41548", "l": "8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine = 8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.307", "l": "\"8-demethyl-8-(2,3-dimethoxy-alpha-L-rhamnosyl)-tetracenomycin-C 4'-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38366", "l": "1-octadecanoylglycerol + H2O <=> glycerol + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666433", "l": "IgG binds the surface of the amastigote form of Leishmania (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102484", "l": "esculetin glucosyltransferase activity"}, {"i": "MetaCyc:RXN-14182"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444647", "l": "C3a receptor binds anaphylatoxin C3a (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56686", "l": "2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + rhizobitoxine => dihydrorhizobitoxine + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17228", "l": "1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin] <=> 6-hydroxynicotinate + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38056", "l": "CTP + phytol => CDP + H(+) + phytyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2545196", "l": "FN1 dimerizes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54998", "l": "3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35276", "l": "3-hydroxyoctadecanoyl-CoA + NAD(+) => 3-oxooctadecanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27900", "l": "adenosine + phosphate => 3'-AMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629917", "l": "NEIL1 Q282TER does not translocate to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45785", "l": "2 H2O + phenylpropanonitrile => 3-phenylpropanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49125", "l": "H(+) + NADPH + O2 + protodeoxyviolaceinate => H2O + NADP(+) + protoviolaceinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429699", "l": "CERT [ER] + ceramide [ER] => CERT:ceramide [ER] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.111", "l": "\"3-(imidazol-5-yl)lactate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388981", "l": "The Kiss receptor GPR54 binds kisspeptin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10501", "l": "butanoyl-CoA + glyoxylate + H2O => 3-ethylmalate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52629", "l": "an N-fatty-acyl-L-alpha-amino acid + H2O => a fatty acid + an L-alpha-amino acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50710", "l": "(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446322", "l": "PARVA associates with Paxillin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.87", "l": "\"Capsular-polysaccharide endo-1,3-alpha-galactosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61870", "l": "1-O-methyl-(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatrienoate => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050471", "l": "uracilylalanine synthase activity"}, {"i": "RHEA:11496", "l": "O-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate + H(+)"}, {"i": "EC:2.5.1.53", "l": "\"Uracilylalanine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13065", "l": "ATP + H2O = ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54005", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26481", "l": "1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) <=> a 2-demethylmenaquinol + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102968", "l": "10-hydroxygeranial oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25196", "l": "(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) <=> 3-methylcatechol + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34676", "l": "CTP + N,N-diacetyllegionaminate => CMP-N,N-diacetyllegionaminate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102432", "l": "quercetin 7-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-13906"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23782", "l": "(2S,3S)-2-methylcitrate + CoA + H(+) => H2O + oxaloacetate + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12079", "l": "an aromatic primary alcohol + NAD(+) <=> an aromatic aldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445079", "l": "Phosphorylation of L1 by ERK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25992", "l": "(2E,6E)-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate"}, {"i": "EC:4.2.3.37", "l": "\"Epi-isozizaene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036056", "l": "Defective HGSNAT does not acetylate Heparan sulfate chain(3) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690152", "l": "USP5 cleaves polyubiquitin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66547", "l": "L-cysteinyl-[protein] + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800797", "l": "The PIDDosome activates CASP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247843", "l": "secretion of WNT ligands (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58185", "l": "H(+) + NADPH + 2 phytyl diphosphate => (14E,18E)-lycopadiene + 2 diphosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140443", "l": "mitochondrion-plasma membrane adaptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "57.639600560502359", "identifiers": [{"i": "GO:0022890", "l": "inorganic cation transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "74.159372409045062", "identifiers": [{"i": "GO:0019787", "l": "small conjugating protein ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25455", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + germacrene A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703438", "l": "FLT3 fusions phosphorylate GAB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28334", "l": "dATP + H2O = dAMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047988", "l": "hydroxyacid-oxoacid transhydrogenase activity"}, {"i": "REACT:R-HSA-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193703", "l": "IKKbeta is activated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48662", "l": "8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047647", "l": "alkylacetylglycerophosphatase activity"}, {"i": "KEGG.REACTION:R03454"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43982", "l": "15-hydroxyhexadecanoate + H2O + NADP(+) => H(+) + hexadecanoate + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14926", "l": "D-mannitol 1-phosphate + NADP(+) => D-mannose 6-phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-398185", "l": "LARG binds plexin B1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59571", "l": "4-aminobutanoate + ATP + L-histidine <=> ADP + H(+) + L-homocarnosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59703", "l": "D-cellopentaono-1,5-lactone + H2O <=> D-cellopentaonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674385", "l": "p-T,Y MAPKs dimerize (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047907", "l": "furylfuramide isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20901", "l": "H(+) + H2O + N-benzyloxycarbonylglycine => benzyl alcohol + CO2 + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37763", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA = 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36416", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine => diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047974", "l": "guanosine deaminase activity"}, {"i": "RHEA:12861", "l": "guanosine + H(+) + H2O = NH4(+) + xanthosine"}, {"i": "EC:3.5.4.15", "l": "\"Guanosine deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10875", "l": "H2O + N-acyl-L-aspartate <=> a carboxylate + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14956", "l": "H(+) + NADPH + O2 + tetradecanoyl-CoA <=> (11Z)-tetradecenoyl-CoA + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52217", "l": "[(1''->2')-ADP-alpha-D-ribose]n + H2O => [(1''->2')-ADP-alpha-D-ribose]n-1 + ADP-D-ribose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168092", "l": "Viral dsRNA binds the Toll-Like Receptor 3 (TLR3) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814555", "l": "Integrator complex processes the 3' end of snRNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140232", "l": "intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785898", "l": "IL4R binds JAK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41756", "l": "1-O-methyl-(9Z,12Z)-octadecadienoate + O2 = 1-O-methyl-(13S)-hydroperoxy-(9Z,11E)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654425", "l": "Activated FGFR4 binds SHC1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43894", "l": "[sulfur carrier]-SH + L-alanine => [sulfur carrier]-H + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39859", "l": "1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycerol = a triacyl-sn-glycerol + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052922", "l": "hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21946", "l": "6-phospho-beta-D-glucosyl-(1->4)-D-glucose + ADP + H(+) => ATP + D-cellobiose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804379", "l": "PRMT5 binds TTC5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12512", "l": "D-aspartate + H2O + O2 = H2O2 + NH4(+) + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62981", "l": "(9Z)-hexadecenamide + H2O => (9Z)-hexadecenoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37107", "l": "H2O + N(7)-methyl-GMP = N(7)-methylguanosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731123", "l": "Syndecan-1 binds Integrin alphaVbeta3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30732", "l": "butanoyl-CoA + FAD + H(+) => (2E)-butenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102942", "l": "3,5-dimethoxyphenol O-methyltransferase activity"}, {"i": "MetaCyc:RXN-9022"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40288", "l": "ATP + CoA + decanedioate => AMP + decanedioyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.25", "l": "\"N-terminal E2 ubiquitin-conjugating enzyme\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57983", "l": "(20S)-protopanaxatriol + UDP-alpha-D-glucose <=> (20S)-ginsenoside F1 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21905", "l": "(2R)-2,3-bisphosphoglycerate + H2O => (2R)-3-phosphoglycerate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22222", "l": "diphosphate + ent-kaur-16-ene => ent-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-532632", "l": "TRAF6 binds to p-IRAK2 complexed with activated TLR7 or TLR21 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956568", "l": "RUNX1 binds the core TAL1 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12801", "l": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72697", "l": "Start codon recognition (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33452", "l": "A + H2O + N(6),N(6)-dimethyl-L-lysyl-[protein] => AH2 + formaldehyde + N(6)-methyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22847", "l": "(6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] <=> glyceollin I + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56501", "l": "(R)-3,5-bisphosphomevalonate + H(+) => CO2 + isopentenyl phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47787", "l": "cytidine(3782) in 28S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(3782) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23495", "l": "UDP-alpha-D-glucosamine <=> UDP-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13990", "l": "alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110159", "l": "TDG glycosylase mediated recognition and binding of an uracil opposite to a guanine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52342", "l": "AMP + H(+) + long-chain fatty acyl-[mycocerosate synthase] => a long-chain fatty acyl-AMP + holo-[mycocerosate synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203130", "l": "OLR1 binds to oxidized LDL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40382", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP <=> 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193703", "l": "IKKbeta is activated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204873", "l": "Interaction of Tie2 and Shp2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47296", "l": "dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12103", "l": "1,5-anhydro-D-fructose <=> H2O + microthecin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871376", "l": "p-Y281,292-RUFY1 binds PI3P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52432", "l": "(R)-2,3-diaminopropanoate + H(+) + H2O = 2 NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2213207", "l": "Formation of collagen networks (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102477", "l": "2,5,7-trihydroxyflavanone 6C-glucoside dehydratase activity"}, {"i": "MetaCyc:RXN-14088"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19112", "l": "1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose <=> 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420274", "l": "GIP receptor binds gastric inhibitory peptide (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34381", "l": "beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 H(+) + 2 UDP => alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 UDP-alpha-D-galactofuranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36262", "l": "a 1-(1-hydroxyalkyl)-sn-glycerol <=> an aldehyde + glycerol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047018", "l": "indole-3-acetaldehyde reductase (NADH) activity"}, {"i": "KEGG.REACTION:R02679"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625693", "l": "TRIM63 gene expression is stimulated by FOXO1 and FOXO3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417843", "l": "P2Y13 binds ADP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40218", "l": "FADH2 + O2 <=> FAD + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102544", "l": "ornaline synthase activity"}, {"i": "MetaCyc:RXN-14880"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47405", "l": "(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) => 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186780", "l": "PI3-kinase binds to the active receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74711", "l": "Phosphorylation of IRS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985201", "l": "ABCE1 binds RNASEL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5631885", "l": "PRDX1 overoxidizes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37632", "l": "(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45860", "l": "12-hydroxyoctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(11-hydroxyheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983150", "l": "Proteasomal cleavage of substrate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32165", "l": "AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine => ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604731", "l": "Autocatalytic activation of MMP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35788", "l": "paromamine + UDP-alpha-D-kanosamine => H(+) + kanamycin C + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390595", "l": "Calcium Binds Troponin-C (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939929", "l": "ESRRA:PPARG1CA binds the RUNX2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14018", "l": "ATP + beta-nicotinamide D-riboside => ADP + beta-nicotinamide D-ribonucleotide + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30391", "l": "4-methylsulfanyl-2-oxobutanoate + L-glutamine = 2-oxoglutaramate + L-methionine"}, {"i": "EC:2.6.1.117", "l": "\"L-glutamine--4-(methylsulfanyl)-2-oxobutanoate aminotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42380", "l": "2 A + all-trans-4,4'-diapolycopene-4,4'-dial + 2 H2O = 2 AH2 + all-trans-4,4'-diapolycopene-4,4'-dioate + 2 H(+)"}, {"i": "RHEA:44716", "l": "A + all-trans-4,4'-diapolycopen-4-al + H2O = AH2 + all-trans-4,4'-diapolycopen-4-oate + H(+)"}, {"i": "EC:1.2.99.10", "l": "\"4,4'-diapolycopenoate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114552", "l": "Thrombin-activated PARs activate G12/13 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3595178", "l": "Defective CHSY1 does not transfer GlcA to chondroitin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50820", "l": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = H(+) + NADPH + testosterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983147", "l": "Release of E3 from polyubiquitinated substrate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399999", "l": "AKT1 E17K mutant phosphorylates RSK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004605", "l": "phosphatidate cytidylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714483", "l": "RAC2 translocates to the ER membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211874", "l": "CYP2S1 4-hydroxylates atRA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948230", "l": "P3HB binds 4-Hyp-collagen propeptides (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49277", "l": "CTP + phytyl phosphate => CDP + phytyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75079", "l": "Formation of AT-AC C complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32241", "l": "all-trans-beta-carotene => gamma-carotene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429415", "l": "SYK binds to integrin alphaIIb beta3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64256", "l": "dodecanoyl-CoA + glycine = CoA + H(+) + N-dodecanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30471", "l": "(2Z,6Z)-farnesyl diphosphate = (-)-endo-alpha-bergamotene + diphosphate"}, {"i": "EC:4.2.3.54", "l": "\"(-)-endo-alpha-bergamotene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37505", "l": "1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51340", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = 10-hydroperoxy-(4Z,7Z,11E,13Z,16Z,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034854", "l": "4,4-dimethyl-3-oxopentanoate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000109", "l": "CD320:TCII:Cbl dissociates into CD320 and TCII:Cbl (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008454", "l": "alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity"}, {"i": "RHEA:16057", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}, {"i": "EC:2.4.1.145", "l": "\"Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62796", "l": "H(+) + NADPH + O2 + 2 rubrofusarin B = aurasperone A + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678822", "l": "Defective CFTR does not transport Cl- from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43009", "l": "D-serine => 2-aminoprop-2-enoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266328", "l": "CETP-mediated lipid exchange: spherical HDL gains triacylglycerol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013438", "l": "RHOD binds effectors at the endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694541", "l": "SARS-CoV-2 gRNA:RTC:RNA primer binds RTC inhibitors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134953", "l": "DHX36 or DHX9 binds MyD88 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031823", "l": "type 1D serotonin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20564", "l": "3-hydroxypyruvate + H(+) <=> CO2 + glycolaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380508", "l": "Translocation of NuMA to the centrosomes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65245", "l": "(2S)-hesperetin + UDP-alpha-D-glucose => (2S)-hesperetin 7-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54520", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = cycloaraneosene + diphosphate"}, {"i": "EC:4.2.3.191", "l": "\"Cycloaraneosene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3780997", "l": "PPP1R3C binds to glycogen:GYG2:GYS2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51365", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine => CoA + H(+) + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034837", "l": "2-mercaptobenzothiazole-cis-6,7-dihydrodiol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388817", "l": "ICOS binds ICOSL/B7-H2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21823", "l": "L-homocysteine + S-adenosyl-L-methionine <=> H(+) + L-methionine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031778", "l": "type 2 melanin-concentrating hormone receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201639", "l": "Caspase-mediated cleavage of GAS2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668545", "l": "NIK autophosphorylates on T559 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944214", "l": "Association of procollagen type I (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848339", "l": "PNPLA5 hydrolyzes TAG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30447", "l": "3-methylxanthine + H(+) + NADH + O2 = formaldehyde + H2O + NAD(+) + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47445", "l": "3-oxo-(7Z-hexadecenoyl)-CoA + CoA => (5Z)-tetradecenoyl-CoA + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46668", "l": "21-hydroxyprogesterone + H(+) + NADPH = 5beta-dihydrodeoxycorticosterone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848758", "l": "PTK6 phosphorylates AKT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24979", "l": "(1S)-1,25-dihydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389941", "l": "SHP-1 and SHP-2 bind pBTLA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140399", "l": "aflatoxin B synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937343", "l": "NLRC5 interacts with DDX58/IFIH1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57960", "l": "dimethyl sulfide + H(+) + NADH + O2 = dimethyl sulfoxide + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53489", "l": "11beta-hydroxyandrost-4-ene-3,17-dione + H(+) + NADPH => 11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390835", "l": "DRD1,5 bind DA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004356", "l": "glutamate-ammonia ligase activity"}, {"i": "REACT:R-HSA-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52187", "l": "(E)-(indol-3-yl)acetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-aci-nitro-2-(1H-indol-3-yl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799097", "l": "ATM phosphorylates ZNF420 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31426", "l": "(2Z,6E)-farnesyl diphosphate <=> (-)-alpha-cedrene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31167", "l": "(3S)-hydroxytetradecanoyl-CoA + NAD(+) = 3-oxotetradecanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63394", "l": "AH2 + Fe(II)-heme i => A + Fe(II)-heme o + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39994", "l": "(4R)-hydroxyeicosasphinganine + a fatty acyl-CoA <=> CoA + H(+) + N-acyl-4-hydroxyeicosasphinganine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070181", "l": "small ribosomal subunit rRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14037", "l": "4,5beta-dihydrocortisone + NADP(+) = cortisone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149539", "l": "MTR transfers CH3 group from MTHF to cob(I)alamin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18854", "l": "NAD(+) + tartrate => 2-hydroxy-3-oxosuccinate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47745", "l": "demethylphylloquinone + H(+) + NADPH => demethylphylloquinol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10336", "l": "citrate = D-threo-isocitrate"}, {"i": "EC:4.2.1.3", "l": "\"Aconitate hydratase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001784", "l": "phosphotyrosine residue binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848339", "l": "PNPLA5 hydrolyzes TAG (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839112", "l": "Phosphorylation of STAT5 by cytosolic FGFR1 fusions (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28834", "l": "D-gluconate(in) + H(+)(in) <=> D-gluconate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3215295", "l": "USP7 deubiquitinates MDM2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000035", "l": "acyl binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390595", "l": "Calcium Binds Troponin-C (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30487", "l": "H(+) + N,N-dihydroxy-L-isoleucine = (1E,2S)-2-methylbutanal oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607733", "l": "BCL10 binds CARD9 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198669", "l": "p38MAPK phosphorylates MSK1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61296", "l": "5-deoxy-alpha-D-ribose 1-phosphate = 5-deoxy-D-ribulose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23902", "l": "(1R,2R)-hydrobenzoin => cis-stilbene oxide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63675", "l": "(S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADH <=> H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52169", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22723", "l": "ATP + L-histidyl-[protein] <=> ADP + H(+) + N(pros)-phospho-L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202466", "l": "Interaction of Bcl10 to CARMA1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57257", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP => GTP + H(+) + lactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654425", "l": "Activated FGFR4 binds SHC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814088", "l": "SYS1 binds AcM-ARFRP1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52511", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848110", "l": "SOCS3 binds activated PTK6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60949", "l": "(S)-eriodictyol + S-adenosyl-L-methionine => (S)-homoeriodictyol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30124", "l": "H2O + tetradecanoyl-[ACP] => H(+) + holo-[ACP] + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28447", "l": "1-deoxy-D-xylulose(in) => 1-deoxy-D-xylulose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-376851", "l": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18675", "l": "ADP + H(+) + O-phospho-L-seryl-[receptor-protein] => ATP + L-seryl-[receptor-protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029468", "l": "Conversion of PA into DAG by PAP-1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31852", "l": "(S)-2,3-epoxysqualene => parkeol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031869", "l": "prostacyclin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605060", "l": "Expression of SCD regulated by NR1H2 or NR1H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.n4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24427", "l": "2 glutathione + L-dehydroascorbate <=> glutathione disulfide + L-ascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28942", "l": "H(+)(in) + xanthosine(in) <=> H(+)(out) + xanthosine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32833", "l": "cob(III)alamin(out) => cob(III)alamin(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163120", "l": "Disassociation of Telomerase RNP and the Chromosome End (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52476", "l": "estrone + UDP-alpha-D-glucuronate = estrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2089971", "l": "Secretion of collagens (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44314", "l": "glycerol + H(+) + tetradecanoate => 1-tetradecanoylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76456", "l": "O-atom dealkylation of dextromethorphan (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57966", "l": "8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15681", "l": "2-hydroxy-5-carboxymethylmuconate semialdehyde + H2O + NAD(+) = (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.60", "l": "\"5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432946", "l": "PARVB/Affixin interacts with alpha PIX (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60790", "l": "CO2 + gibberellin A9 + H2O => gibberellin A24 + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706312", "l": "Active FLT3 binds to LCK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156682", "l": "PLK1 phosphorylates NUDC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41351", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48430", "l": "(9Z,12Z)-octadecadienoate + glycerol + H(+) => 1-(9Z,12Z-octadecadienoyl)-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49084", "l": "(-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase] = (-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.19.72", "l": "\"(-)-pluviatolide synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2990882", "l": "CDK1 phosphorylates NUP98 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n2", "l": "\"Delta-selinene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928620", "l": "PAK1 autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2530429", "l": "Formation of soluble VTN:C5b-C9  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641134", "l": "SMURF2 binds AXIN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17067", "l": "(R)-5-phosphomevalonate + ADP + H(+) => (R)-mevalonate + ATP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102097", "l": "(22S)-22-hydroxy-5alpha-campestan-3-one C-23 hydroxylase activity"}, {"i": "MetaCyc:RXN-11101"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24266", "l": "D-glyceraldehyde 3-phosphate + dihydroxyacetone => D-xylulose 5-phosphate + formaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55404", "l": "[phosphate](n) + UTP = [phosphate](n+1) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51380", "l": "(9Z)-octadecenoyl-CoA + dopamine = CoA + H(+) + N-(9Z-octadecanoyl)-dopamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44353", "l": "ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate => ADP + dapdiamide C + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60478", "l": "cyclic AMP-AMP-GMP + 3 diphosphate => 2 ATP + GTP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990409", "l": "adrenomedullin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202443", "l": "Oligomerization of CARMA1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23252", "l": "[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928660", "l": "ADAM10 cleaves EFNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19931", "l": "[(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP => [(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37723", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051212", "l": "vanadium ion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050613", "l": "delta14-sterol reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5578712", "l": "Importin-8 binds AGO2:miRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001587", "l": "Gq/11-coupled serotonin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41901", "l": "H(+) + malonyl-[ACP] + tetradecanoyl-[ACP] => 3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52121", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65873", "l": "1,17beta-dihydroxyandrostan-3-one + A => 17beta-hydroxyandrostan-1,3-dione + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388830", "l": "PI3K binds ICOS (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011224", "l": "ROBO3.1 binds DCC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13582", "l": "N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636457", "l": "SapM dephosphorylates PI3P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61825", "l": "pregnenolone + UDP-alpha-D-glucose => H(+) + pregnenolone 3-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52181", "l": "(E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] => (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-560472", "l": "Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44354", "l": "ADP + dapdiamide C + H(+) + phosphate => ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38736", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-hexadecanoylglycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.9.-", "l": "\"With a copper protein as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55889", "l": "[aequorin]--dioxetanone => [excited state blue fluorescent protein] + CO2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097682", "l": "intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507869", "l": "Aquaporins passively transport glycerol into cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50958", "l": "H(+) + N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine => cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950405", "l": "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374337", "l": "Apelin receptor binds to apelin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33627", "l": "ATP + CoA + decanoate = AMP + decanoyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51158", "l": "AMP + diphosphate + L-glutamyl-tRNA(Gln) => ATP + L-glutamate + tRNA(Glu)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34013", "l": "ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2 => ergosta-5,7,24(28)-trien-3beta-ol + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804741", "l": "MDM2 forms homo- or heterodimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65158", "l": "CO2 + H2O + preaustinoid A3 + succinate => 2-oxoglutarate + O2 + preaustinoid A2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44043", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> 14,15-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61444", "l": "a tetracycline + H(+) + NADPH + O2 = an 11a-hydroxytetracycline + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212356", "l": "Formation of CSL-NICD coactivator complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28764", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-D-galactose => CoA + dTDP-4-acetamido-4,6-dideoxy-D-galactose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196017", "l": "Dynamin is recruited to the gap junction plaque (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50653", "l": "2-(3-methylsulfanyl)propylmalate => 2-(2-methylsulfanyl)propylmaleate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55688", "l": "an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + H2O = 1D-myo-inositol 1-phosphate + an N-acyl-(4R)-4-hydroxysphinganine + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004649", "l": "poly(ADP-ribose) glycohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0098847", "l": "sequence-specific single stranded DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56180", "l": "8-carboxy-8-demethylriboflavin 5'-phosphate + 2 A + H2O + L-glutamate = 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 2 AH2 + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52925", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate => 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686359", "l": "SFTPs translocate from extracellular region to clathrin-coated vesicle (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004078", "l": "biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102726", "l": "DIMBOA glucoside beta-D-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37752", "l": "2-methyl-trans-aconitate => 2-methyl-cis-aconitate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65681", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontenoyl)-sphing-4-enine => a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33705", "l": "CoA + H(+) + N-hexacosanoyl-eicosan-(4R)-hydroxysphinganine => (4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380311", "l": "Recruitment of Plk1 to centrosomes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59436", "l": "4-amino-L-phenylalanine + ATP + holo-[peptidyl-carrier protein] = 4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023840", "l": "HATs and coactivators are recruited to the CTSD gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-706479", "l": "TAK1 is activated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13271", "l": "an N-acylsphing-4-enine + D-glucose => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34782", "l": "a 3alpha-hydroxysteroid + NAD(+) <=> a 3-oxosteroid + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44757", "l": "2-methoxy-6-all-trans-heptaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34022", "l": "a 1-acylglycerol + H2O <=> a fatty acid + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034618", "l": "arginine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48894", "l": "L-threonyl-[protein] + N-acetyl-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868783", "l": "TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66388", "l": "ATP + H2O + prostaglandin E2(in) = ADP + H(+) + phosphate + prostaglandin E2(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12453", "l": "1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38428", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O => 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170986", "l": "Ral-GDS binds to Ras-GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693783", "l": "NAALADases hydrolyse NAAG (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2562541", "l": "TLR4-induced ripoptosome assembly (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9640195", "l": "RRAGA,B hydrolyzes GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36594", "l": "(S)-2-chloropropanoate + NADP(+) <=> 2-chloroacrylate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20216", "l": "L-lysyl-[lipoyl-carrier protein] + N(6)-octanoyl-L-lysyl-[glycine-cleavage complex H protein] <=> L-lysyl-[glycine-cleavage complex H protein] + N(6)-octanoyl-L-lysyl-[lipoyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46725", "l": "(2S)-2-methyltetradecanoyl-CoA => (2R)-2-methyltetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-708349", "l": "Activated NOD2 oligomerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5695964", "l": "ABHD14B hydrolyses PNPB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-549304", "l": "OCT3 mediates renal clearance of organic cations (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14998", "l": "deoxylimonoate + H2O => deoxylimononate D-ring-lactone + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72722", "l": "eIF2 activation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428918", "l": "Dissociation of the TP:G13 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13269", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose"}, {"i": "EC:3.2.1.45", "l": "\"Glucosylceramidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668605", "l": "RAC2:GTP binds NOX2 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44030", "l": "5-dehydro-4-deoxy-D-glucarate + H2O => L-altrarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351894", "l": "Caspase mediated cleavage of BAP31 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28669", "l": "(S)-propane-1,2-diol + NAD(+) => H(+) + hydroxyacetone + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12248", "l": "NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine"}, {"i": "EC:1.3.1.98", "l": "\"UDP-N-acetylmuramate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36135", "l": "(2E)-hexadecenal + H2O + NAD(+) = (E)-hexadec-2-enoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15907", "l": "AH2 + cyclohexane-1,3-dione => 3-hydroxycyclohexanone + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11859", "l": "1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "74.836269892493803", "identifiers": [{"i": "GO:0048018", "l": "receptor ligand activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047455", "l": "16-alpha-hydroxyprogesterone dehydratase activity"}, {"i": "RHEA:12584", "l": "16alpha-hydroxyprogesterone = 16,17-didehydroprogesterone + H2O"}, {"i": "EC:4.2.1.98", "l": "\"16-alpha-hydroxyprogesterone dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32381", "l": "(1R,4S)-1-hydroxylimonen-2-one + H(+) + NADH => (1R,2R,4S)-limonene-1,2-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40835", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2 H2O = 2 (9Z)-octadecenoate + 2 H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64687", "l": "L-threonyl-[protein] + UDP-alpha-D-glucose <=> 3-O-(alpha-D-glucosyl)-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38288", "l": "(3S)-citramalate + succinyl-CoA => (3S)-citramalyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56593", "l": "a disubstituted aliphatic (S)-hydroxynitrile => a ketone + hydrogen cyanide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34454", "l": "dTDP-6-deoxy-beta-L-talose <=> dTDP-beta-L-rhamnose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15332", "l": "(S)-ureidoglycolate + NAD(+) <=> H(+) + N-carbamoyl-2-oxoglycine + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374696", "l": "Phosphorylation of L1 by p90rsk (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64405", "l": "carnosine(out) + H(+)(out) => carnosine(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20156", "l": "ATP + L-arabinose <=> ADP + beta-L-arabinose 1-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855648", "l": "SALM3 binds LAR-RPTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33918", "l": "4-(methylamino)butanoate + H2O + O2 <=> H2O2 + methylamine + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12771", "l": "2-dehydro-D-gluconate + AH2 => A + D-gluconate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51246", "l": "(13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16091", "l": "ethanolamine + phosphate => H2O + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18844", "l": "(R)-glycerate + NADP(+) <=> 2-hydroxy-3-oxopropanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653974", "l": "Ragulator binds Rag dimers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42555", "l": "uridine(31) in tRNA <=> pseudouridine(31) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937814", "l": "RUNX3 translocates to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24329", "l": "7,8-dihydrofolate + ATP + formate => 10-formyldihydrofolate + ADP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953111", "l": "E2F6 binds TFDP1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60861", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24498", "l": "CoA + vindoline => 4-O-deacetylvindoline + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50577", "l": "acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466822", "l": "Defective OPN1LW causes BCM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376134", "l": "NrCAM binds synapse-associated proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15728", "l": "1,5-anhydro-D-fructose <=> ascopyrone M + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433864", "l": "IRAK2 binds to the IRAK4 accociated  with the complex of the activated TLR : TIRAP : MyD88 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53398", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+) => dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50499", "l": "acetyl-CoA + N-terminal glycyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetylglycyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11311", "l": "acetyl-CoA + ATP + hydrogencarbonate <=> ADP + H(+) + malonyl-CoA + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67012", "l": "a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate"}, {"i": "EC:2.7.7.50", "l": "\"mRNA guanylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50408", "l": "1-(2-aminophenyl)decane-1,3-dione = 2-heptyl-4(1H)-quinolone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909718", "l": "Formation of p-STAT1 homodimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050232", "l": "putrescine oxidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047649", "l": "alkylglycerol kinase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001072", "l": "transcription antitermination factor activity, RNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199298", "l": "AKT phosphorylates CREB1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53822", "l": "7-oxolithocholate + H(+) + NADPH => chenodeoxycholate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389978", "l": "alpha-tubulin:GTP + Cofactor E ->  alpha-tubulin:GTP:Cofactor E (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38815", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21461", "l": "benzoin => 2 benzaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6791235", "l": "GADD45A binds AURKA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090542", "l": "ELYC domain binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043886", "l": "structural constituent of carboxysome"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62655", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA <=> 6 CO2 + 7 CoA + H2O + YWA1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63143", "l": "H2O + N-tetracosanoyl-taurine <=> taurine + tetracosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685953", "l": "SIRT6 deacetylates RBBP8 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9606151", "l": "Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19740", "l": "4-(gamma-L-glutamylamino)butanoate + H2O <=> 4-aminobutanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9723906", "l": "Defective TP53 does not tetramerize (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62258", "l": "Cd(2+)(in) + 2 hydrogencarbonate(in) => Cd(2+)(out) + 2 hydrogencarbonate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19555", "l": "indole + NH4(+) + pyruvate => H2O + L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40006", "l": "ent-copalyl diphosphate <=> (Z)-biformene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-417842", "l": "P2Y10 receptor can bind to LPA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70481", "l": "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20991", "l": "ATP + 2 H2O <=> AMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432164", "l": "Ca2+ influx into the post-synaptic cell (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21131", "l": "5alpha-cholesta-8,24-dien-3beta-ol + S-adenosyl-L-methionine <=> 24-methylene-5alpha-cholest-8-en-3beta-ol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55334", "l": "a 3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => a 3'-hydroxyflavone + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50108", "l": "hexadecanoyl-CoA + taurine = CoA + H(+) + N-hexadecanoyl-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48839", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033822", "l": "glucosyl-DNA beta-glucosyltransferase activity"}, {"i": "MetaCyc:2.4.1.28-RXN"}, {"i": "EC:2.4.1.28", "l": "\"Glucosyl-DNA beta-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42346", "l": "(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) => H(+) + NADH + O2 + p-cumate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2272753", "l": "Interaction of DAP12 and KIR2DS4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39696", "l": "3-oxo-(13Z)-eicosenoyl-CoA + H(+) + NADPH => (R)-3-hydroxy-(13Z)-eicosenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004638", "l": "phosphoribosylaminoimidazole carboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75850", "l": "Addition of the third nucleotide on the nascent transcript (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.15"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74742", "l": "Phosphorylation of SHC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31930", "l": "3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9651456", "l": "SERPING1 variant does not bind factor XIIa (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2855047", "l": "Hydrolysis of internal thioester in C4b (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001069", "l": "glycogen binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41066", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9017507", "l": "RHOJ binds effectors at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170846", "l": "TGFBR2 recruits TGFBR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035438", "l": "cyclic-di-GMP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39175", "l": "(3R)-hydroxyeicosanoyl-CoA = (2E)-eicosenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22555", "l": "3'-phosphoadenylyl sulfate + an alcohol <=> adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24092", "l": "2 H(+) + O2 + 2 sulochrin = 2 (2S)-bisdechlorogeodin + 2 H2O"}, {"i": "EC:1.21.3.4", "l": "\"Sulochrin oxidase ((+)-bisdechlorogeodin-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52315", "l": "NAD(+) + thromboxane B2 <=> 11-dehydro-thromboxane B2 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785165", "l": "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0030249", "l": "guanylate cyclase regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5622134", "l": "CRABP1 binds atRA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23141", "l": "beta-nicotinamide D-ribonucleotide + H2O => D-ribose 5-phosphate + H(+) + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14552", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O <=> 2-oxopent-4-enoate + formate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11908", "l": "H2O + nonane-4,6-dione = butanoate + H(+) + pentan-2-one"}, {"i": "EC:3.7.1.7", "l": "\"Beta-diketone hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709842", "l": "MAVS binds TOMM70 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247836", "l": "Retromer recycles WLS to the Golgi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097718", "l": "disordered domain specific binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62730", "l": "(+)-malbrancheamide D + FADH2 => (+)-malbrancheamide B + bromide + FAD + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63734", "l": "UDP + zolarsartan O-beta-D-glucuronoside => UDP-alpha-D-glucuronate + zolasartan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59857", "l": "[Co(I) tetramethylammonium-specific corrinoid protein] + H(+) + tetramethylammonium => [methyl-Co(III) tetramethylammonium-specific corrinoid protein] + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14903", "l": "casbene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22623", "l": "H(+) + L-tryptophan + O2 <=> 3-indoleglycolaldehyde + CO2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34846", "l": "7,8-dihydromonapterin 3'-triphosphate + 3 H2O <=> 7,8-dihydromonapterin + 2 H(+) + 3 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61179", "l": "(E)-caffeoyl-CoA + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside <=> CoA + H(+) + quercetin 3-O-[(6-O-[(E)-caffeoyl]-beta-D-glucosyl)-(1->2)-beta-D-glucoside]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48945", "l": "ADP + bacteriochlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate => 3-acetyl-3-devinylchlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34476", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate => 15-cis-phytoene + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607737", "l": "BCL10 oligomerizes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13572", "l": "ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> beta-D-GalNAc-(1->4)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25402", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate <=> (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35604", "l": "beta-D-fructose 1-phosphate + H2O => D-fructose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56064", "l": "3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP"}, {"i": "EC:2.4.2.42", "l": "\"UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944242", "l": "Association of procollagen type XXVII (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418856", "l": "Activation of Rac1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41942", "l": "[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ADP + H(+) + phosphate => [amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43852", "l": "H(+) + malonyl-CoA + triacontanoyl-CoA = 3-oxo-dotriacontanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20389", "l": "(2R,3R)-dihydroquercetin + H(+) + NADPH + O2 = (2R,3R)-2,3-dihydrogossypetin + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161668", "l": "PGA2 is dehydrated to 15d-PGA2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944457", "l": "MAF1 translocates to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "76.125169645393314", "identifiers": [{"i": "GO:0140103", "l": "catalytic activity, acting on a glycoprotein"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371591", "l": "Trimerization of cytosolic HSF1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31090", "l": "acetyl-CoA + octanoyl-CoA <=> 3-oxodecanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43400", "l": "N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose = H(+) + N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33812", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 glycine + 3 L-threonine => 6 AMP + corynebactin + 6 diphosphate + 3 H(+) + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36504", "l": "(9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA => (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265823", "l": "Association between RAD9 and TopBP1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52907", "l": "15,17(3)-seco-F430-17(3)-acid + ATP <=> ADP + coenzyme F430 + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199404", "l": "CD40L binds CD40 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29123", "l": "nitrate(out) + ubiquinol-8(in) = H2O(out) + nitrite(out) + ubiquinone-8(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080077", "l": "trihydroxyferuloyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5679239", "l": "ULK complex translocates to the ER (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15376", "l": "columbamine + S-adenosyl-L-methionine <=> H(+) + palmatine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40461", "l": "(2E)-pristenoyl-CoA + H2O2 => (2S)-pristanoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52178", "l": "14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47782", "l": "a 5-methylcytidine in 25S rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in 25S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854738", "l": "CSF3 dimer:CSFR binds CSFR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44311", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046990", "l": "N-hydroxyarylamine O-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036054", "l": "protein-malonyllysine demalonylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008412", "l": "CDK4 phosphorylates RUNX2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.112", "l": "\"Oxaloacetate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865605", "l": "BRWD1 binds SMARCA4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805285", "l": "PLK3 phosphorylates TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45637", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199299", "l": "AKT phosphorylates FOXO transcription factors (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51284", "l": "(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate = (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2248891", "l": "Active ARSA translocates to the lysosome (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106240", "l": "labd-13Z-ene-9,15,16-triol synthase activity"}, {"i": "RHEA:62192", "l": "O2 + peregrinol + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65338", "l": "chrodrimanin A + H2O + NADP(+) => chrodrimanin T + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951644", "l": "Release of mature NEDD8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49830", "l": "(2E,5E)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (5E)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28398", "l": "H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate = L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54736", "l": "N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-205136", "l": "GTP-bound RAC contributes to JNK activation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28770", "l": "ethylnitronate + O2 <=> acetaldehyde + chemical entity + H(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909729", "l": "Activation of JAK kinases (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29893", "l": "ADP + H(+) + L-histidine(in) + phosphate => ATP + H2O + L-histidine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62082", "l": "6-sulfo-D-glucono-1,5-lactone + H(+) + NADPH => D-glucose 6-sulfate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55121", "l": "4-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-4-methylhexanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0009038", "l": "undecaprenol kinase activity"}, {"i": "EC:2.7.1.66", "l": "\"Undecaprenol kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48325", "l": "ganglioside GD1b + GDP-beta-L-fucose => ganglioside Fuc-GD1b + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30071", "l": "acetyl-CoA + butanoate = acetate + butanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1793176", "l": "DS is cleaved from its proteoglycan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21986", "l": "adenosine 3',5'-bisphosphate + choline sulfate + H(+) => 3'-phosphoadenylyl sulfate + choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41032", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + decanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-decanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000774", "l": "adenyl-nucleotide exchange factor activity"}, {"i": "REACT:R-HSA-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804099", "l": "HMGB1 binds LTP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111956", "l": "Calmodulin activates Cam-PDE 1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58164", "l": "(2E,6E)-farnesyl diphosphate + 2 H2O = 7-epi-ent-eudesmane-5,11-diol + diphosphate"}, {"i": "EC:4.2.3.197", "l": "\"Eudesmane-5,11-diol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803060", "l": "DCD(63-110) is processed to DCD(63-109) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40564", "l": "dTDP-N-hydroxy-beta-L-evernosamine + H(+) + NADPH + O2 => dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1364044", "l": "PRLR:JAK2 dimerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40194", "l": "(3R)-hydroxyoctanoyl-CoA + NAD(+) <=> 3-oxooctanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61119", "l": "(2R,3R)-dihydroquercetin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2R,3R)-dihydromyricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211193", "l": "Homodimerization  of DFF40 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55758", "l": "a 2-hydroxyornithine lipid + CO2 + succinate => 2-oxoglutarate + an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20552", "l": "2 [Fe(III)cytochrome c] + 2 thiosulfate <=> 2 [Fe(II)cytochrome c] + 2 H(+) + tetrathionate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2201293", "l": "Endocytosis of TLR4:LY96:LPS:CD14 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57285", "l": "a guanosine in RNA + methylglyoxal => an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197958", "l": "FPGS-2 transforms THF to THFPG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63791", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102457", "l": "cyanidin 3-O-glucoside 7-O-glucosyltransferase (vanilloyl-glucose dependent) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-901047", "l": "Binding of ERp57 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696491", "l": "CNTF binds CNTFR complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23277", "l": "2-dehydropantoate => 3-methyl-2-oxobutanoate + formaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196929", "l": "FLAD1 phosphorylates FMN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849102", "l": "SRMS phosphorylates PTK6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20107", "l": "AMP + beta-D-fructose 1,6-bisphosphate + H(+) => ADP + beta-D-fructose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32210", "l": "(2E,4Z)-2-hydroxyhexa-2,4-dienedioate <=> (3Z)-2-oxohex-3-enedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395517", "l": "NADPH transfers electrons to FDXR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10709", "l": "alpha-D-glucose 1-phosphate + GTP + H(+) => diphosphate + GDP-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875451", "l": "MET phosphorylates CBL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19148", "l": "D-glucose 6-sulfate + H2O <=> D-glucose + H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64711", "l": "butan-1-ol + NADP(+) <=> butanal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55143", "l": "D-alanyl-5'-AMP + holo-[D-alanyl-carrier protein] <=> AMP + D-alanyl-[D-alanyl-carrier protein] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56988", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54645", "l": "trans-4-hydroxy-L-proline => (S)-1-pyrroline-5-carboxylate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40354", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP <=> 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53800", "l": "lithocholoyl-CoA + ursodeoxycholate = lithocholate + ursodeoxycholoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181355", "l": "Phosphorylation of R-SMAD2/3 by NODAL receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47056", "l": "4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9690494", "l": "RHOB translocates to the endosome membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353301", "l": "Binding of Pol kappa and REV1 complex to the lesion on the template DNA strand (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20269", "l": "4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate = 2 5-dehydro-4-deoxy-D-glucuronate"}, {"i": "EC:4.2.2.6", "l": "\"Oligogalacturonide lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56165", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3-phosphocholine => (9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201630", "l": "Caspase-mediated cleavage of Acinus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848930", "l": "PTK6 translocates to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17701", "l": "ATP + geranoyl-CoA + hydrogencarbonate = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + H(+) + phosphate"}, {"i": "EC:6.4.1.5", "l": "\"Geranoyl-CoA carboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20500", "l": "2-arylethylamine + acetyl-CoA <=> CoA + H(+) + N-acetyl-2-arylethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24050", "l": "alpha-D-glucose 1-phosphate + D-fructose => phosphate + sucrose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20004", "l": "glycolaldehyde + H2O + NAD(+) <=> glycolate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050621", "l": "tryptophan alpha,beta-oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43143", "l": "guanosine(26) in tRNA + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32127", "l": "2-oxoglutarate + L-proline + O2 = cis-4-hydroxy-L-proline + CO2 + succinate"}, {"i": "EC:1.14.11.56", "l": "\"L-proline cis-4-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809680", "l": "MTMR12 binds MTM1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034921", "l": "cis-4,5-dihydroxy-4,5-dihydropyrene dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59665", "l": "D-cellopentaose + O2 => D-cellopentaono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662647", "l": "MT4 binds copper (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47230", "l": "(2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein] => docosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36012", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097007", "l": "4,8,12-trimethyltrideca-1,3,7,11-tetraene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952371", "l": "MDM2 binds RUNX3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139917", "l": "tBID activates BAX protein (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54497", "l": "ent-copalyl diphosphate => diphosphate + ent-atiserene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.99.-", "l": "\"Other protein kinases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5252133", "l": "ATP6AP1 binds V-ATPase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43744", "l": "ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)"}, {"i": "EC:6.3.4.19", "l": "\"tRNA(Ile)-lysidine synthetase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380272", "l": "Plk1-mediated phosphorylation of Nlp (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25613", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = terpentedienyl diphosphate"}, {"i": "EC:5.5.1.15", "l": "\"Terpentedienyl-diphosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46419", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (6Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202453", "l": "Auto-ubiquitination of TRAF6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140306", "l": "lipoprotein releasing activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30817", "l": "beta-nicotinamide D-riboside + phosphate => beta-nicotinamide D-ribonucleotide + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043805", "l": "indolepyruvate ferredoxin oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55341", "l": "(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol => 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59173", "l": "hexadecanoyl-AMP + holo-[(hydroxy)phthioceranic acid synthase] => AMP + H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675948", "l": "TNFRSF6B binds TNFSF6,14,15 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42954", "l": "5-methylcytidine(49) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(49) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026008", "l": "Epoxide hydrolase hydrolyses 7,8-epoxy-HDPAn-3 to RvD1n-3DPA or RvD2n-3DPA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016621", "l": "cinnamoyl-CoA reductase activity"}, {"i": "MetaCyc:CINNAMOYL-COA-REDUCTASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20052", "l": "1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O <=> 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388811", "l": "CD28 homodimer binds B7-1 homodimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53713", "l": "2 Fe(III)-heme b => beta-hematin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43472", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31918", "l": "ATP + D-maltose <=> ADP + alpha-maltose 1-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004392", "l": "heme oxygenase (decyclizing) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50401", "l": "L-cysteinyl-[PqsC protein] + octanoyl-CoA => CoA + S-octanoyl-L-cysteinyl-[PqsC protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65154", "l": "(2S)-naringenin 7-O-beta-D-glucoside + H(+) + UDP => (2S)-naringenin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913456", "l": "Interleukin-5 receptor alpha subunit binds Interleukin-5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45730", "l": "(E)-caffeyl aldehyde + H(+) + NADPH => (E)-caffeyl alcohol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42403", "l": "lactose(out) + N(pros)-phospho-L-histidyl-[protein] <=> L-histidyl-[protein] + lactose 6-phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12913", "l": "(R)-lipoate + ATP + H(+) = (R)-lipoyl-5'-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-947499", "l": "Exchange of oxygen with sulfur in MoCo (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55133", "l": "ATP + D-alanine + holo-[D-alanyl-carrier protein] => AMP + D-alanyl-[D-alanyl-carrier protein] + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61369", "l": "4-methylumbelliferone sulfate(in) + ATP + H2O => 4-methylumbelliferone sulfate(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13262", "l": "2-methylbutanoyl-CoA + A => 2-methylbut-2-enoyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12082", "l": "3-oxobutanoyl-[ACP] + CO2 + CoA => acetyl-CoA + H(+) + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19258", "l": "a secondary alcohol + NADP(+) => a ketone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69068", "l": "RFC dissociates after sliding clamp formation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27833", "l": "neryl diphosphate <=> beta-phellandrene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196964", "l": "RFK:Mg2+ phosphorylates RIB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49859", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174119", "l": "Free APC/C phosphorylated by Plk1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033461", "l": "GGU codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195378", "l": "Homodimerization of VEGF proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64096", "l": "3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] = 2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-888589", "l": "Release of GABA at the synapse (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351849", "l": "Caspase-mediated cleavage of Etk (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047413", "l": "N(alpha)-benzyloxycarbonylleucine hydrolase activity"}, {"i": "RHEA:18901", "l": "H(+) + H2O + N-benzyloxycarbonyl-L-leucine = benzyl alcohol + CO2 + L-leucine"}, {"i": "EC:3.5.1.64", "l": "\"N(alpha)-benzyloxycarbonylleucine hydrolase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033402", "l": "UUC codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696605", "l": "USP12, USP26 deubiquitinate AR (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164522", "l": "Terminal (3' end) cleavage of viral DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102376", "l": "lupeol 28-oxidase activity"}, {"i": "MetaCyc:RXN-13507"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160915", "l": "Receptor-mediated uptake of HA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791075", "l": "Expression of DNAJB11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939039", "l": "PPANT translocates from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805792", "l": "p-S291-PHF20 translocates to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53270", "l": "L-xylulose => L-ribulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64207", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(10Z-heptadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56830", "l": "2,3,5,6-tetrachlorohydroquinone + 2 glutathione => 2,3,6-trichlorohydroquinone + chloride + glutathione disulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805479", "l": "TP53RK phosphorylates TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56592", "l": "a disubstituted aliphatic (S)-hydroxynitrile = a ketone + hydrogen cyanide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652137", "l": "Damaged dsDNA becomes damaged DNA template (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047501", "l": "(+)-neomenthol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65119", "l": "2-oxoglutarate + aculene B + O2 <=> aculene A + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009485", "l": "IL34:CSF1 binds CSF1R (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.23", "l": "\"Ribotoxin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14148", "l": "ATP + guanidinoacetate <=> ADP + H(+) + phosphoguanidinoacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928614", "l": "EFNB:GRB4 binds GIT1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46439", "l": "(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta,4beta-dihydroxycholest-5-en-26-oate + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31556", "l": "(5S)-5-amino-3-oxohexanoate + acetyl-CoA => (3S)-3-aminobutanoyl-CoA + acetoacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202500", "l": "Activation of IKK complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38954", "l": "ATP + H2O + sphing-4-enine 1-phosphate(in) <=> ADP + H(+) + phosphate + sphing-4-enine 1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453200", "l": "SYK autophosphorylates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41652", "l": "aclacinomycin S + dTDP-2-deoxy-beta-L-fucose = 2-deoxy-alpha-L-fucosylaclacinomycin S + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202222", "l": "Phosphorylation of PKC theta (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21058", "l": "acryloyl-CoA + H2O => lactoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27745", "l": "2'-deoxyadenosine + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + adenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42289", "l": "6-carboxyhexanoyl-[ACP] + H(+) + L-alanine => (S)-8-amino-7-oxononanoate + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21403", "l": "2-oxoglutarate + CoA + NADP(+) <=> CO2 + NADPH + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9734730", "l": "ORC1 translocates to the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374701", "l": "Phosphorylation of DCC by Fyn (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11089", "l": "H2O + trimetaphosphate => 2 H(+) + triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9626928", "l": "CREBBP binds FOXO1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446364", "l": "Migfilin interacts with VASP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44574", "l": "2-all-trans-heptaprenylphenol + CO2 => 4-hydroxy-3-all-trans-heptaprenylbenzoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0070546", "l": "L-phenylalanine aminotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351208", "l": "Spermidine  => N-acetylated spermidine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201622", "l": "Caspase-mediated cleavage of gelsolin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31358", "l": "dimethyl sulfide + H(+) + NADH + O2 <=> formaldehyde + H2O + methanethiol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54813", "l": "(+)-7-isojasmonate + ATP + L-isoleucine => AMP + diphosphate + H(+) + L-isoleucine-(+)-7-isojasmonate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033790", "l": "hydroxymethylfurfural reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007591", "l": "E2F6 binds RRM2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211910", "l": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16801", "l": "3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] = adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein]"}, {"i": "EC:2.8.2.20", "l": "\"Protein-tyrosine sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32846", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycerol <=> a 1-acyl-sn-glycero-3-phosphocholine + a triacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004510", "l": "tryptophan 5-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38473", "l": "3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine => L-histidine + 3 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63801", "l": "GDP-alpha-D-mannose => GDP-beta-L-gulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48844", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33467", "l": "ergosta-5,7,24(28)-trien-3beta-ol + H(+) + NADPH + O2 = ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+)"}, {"i": "RHEA:46576", "l": "(24R)-ethylcholest-5-en-3beta-ol + H(+) + NADPH + O2 = 2 H2O + NADP(+) + stigmasterol"}, {"i": "EC:1.14.19.41", "l": "\"Sterol 22-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30729", "l": "dADP + H(+) + phosphoenolpyruvate => dATP + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507871", "l": "Aquaporins passively transport glycerol out of cells (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13786", "l": "citramalyl-CoA => H2O + itaconyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784959", "l": "BPHL hydrolyses VACV to ACV (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102646", "l": "14betaH-scalarane-17alpha-19-diol synthase activity"}, {"i": "MetaCyc:RXN-15759"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952996", "l": "E2F7 forms homodimers (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53488", "l": "11beta-hydroxyandrost-4-ene-3,17-dione + H(+) + NADPH = 11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5195402", "l": "CDK1 phosphorylates LPIN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56717", "l": "H2O + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein] => H(+) + S-disulfanyl-L-cysteinyl-[SoxY protein] + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16241", "l": "an NDP-alpha-D-glucose + D-fructose = a ribonucleoside 5'-diphosphate + H(+) + sucrose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27809", "l": "acetoacetate + acetyl-CoA <=> acetate + acetoacetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.125", "l": "\"Sucrose--1,6-alpha-glucan 3(6)-alpha-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37575", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051921", "l": "adenosylcobyric acid synthase (glutamine-hydrolyzing) activity"}, {"i": "MetaCyc:R345-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198599", "l": "AKT phosphorylates MDM2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.56", "l": "\"Insulysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050611", "l": "arsenate reductase (azurin) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786583", "l": "PUS7 transforms uridine to pseudouridine in tRNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53866", "l": "7,12-dioxo-lithocholate + H(+) + NADPH => 3alpha,7beta-dihydroxy-12-oxo-5beta-cholan-24-oate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49871", "l": "(+)-dehydrodiconiferyl acid + a quinone <=> (+)-dehydrodiconiferyl acid ketone + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52672", "l": "2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate = [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66841", "l": "asperterpenoid A + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => asperterpenoid B + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22844", "l": "(6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] = glyceollin I + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6794347", "l": "Homer1,2,3 dimerizes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27914", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56967", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + pyruvate <=> a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730872", "l": "Activation of Calcineurin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035486", "l": "cytosine/cytosine mispair binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-179410", "l": "Association of Nek2A with MCC:APC/C (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176517", "l": "SULTs transfer (SO4)2- group to PREG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668735", "l": "RAC1:GTP binds NOX3 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0043028", "l": "cysteine-type endopeptidase regulator activity involved in apoptotic process"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38905", "l": "a sphingomyelin(out) + ADP + H(+) + phosphate => a sphingomyelin(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60215", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56682", "l": "H2O + omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized [2Fe-2S]-[ferredoxin] => beta-dihydromenaquinone-9 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13648", "l": "beta-D-glucose + NADP(+) <=> D-glucono-1,5-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46169", "l": "ATP + CoA + pentanoate => AMP + diphosphate + pentanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11904", "l": "2-amino-4-hydroxypteridine + H(+) + H2O = 2,4-dihydroxypteridine + NH4(+)"}, {"i": "RHEA:36055", "l": "a 2-amino-4-hydroxypteridine + H(+) + H2O = a 2,4-dihydroxypteridine + NH4(+)"}, {"i": "EC:3.5.4.11", "l": "\"Pterin deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31366", "l": "NADP(+) + reduced coenzyme F420-(gamma-Glu)(n) <=> 2 H(+) + NADPH + oxidized coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41061", "l": "1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + CoA => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53747", "l": "glycyl-tRNA(Ala) + H2O <=> glycine + H(+) + tRNA(Ala)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034611", "l": "oligoribonucleotidase activity"}, {"i": "REACT:R-HSA-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Homo sapiens)"}, {"i": "REACT:R-HSA-9615042", "l": "Viral 2',5'-PDE cleaves 2'-5' oligoadenylates  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110311", "l": "POLZ extends translesion synthesis (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57895", "l": "a quinone + 5 H(+)(in) + NADPH <=> a quinol + 4 H(+)(out) + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190245", "l": "FGFR1b binds to FGF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1254291", "l": "ERBB4s80 binds STAT5A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008900", "l": "P-type potassium:proton transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.12.2", "l": "\"Mitogen-activated protein kinase kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10737", "l": "a primary alcohol + NAD(+) => an aldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.15.4", "l": "\"Peptidyl-dipeptidase B\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16164", "l": "2 [Fe(III)-leghemoglobin] + NADH <=> 2 [Fe(II)-leghemoglobin] + H(+) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59167", "l": "ATP + hexadecanoate + holo-[(hydroxy)phthioceranic acid synthase] <=> AMP + diphosphate + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797810", "l": "PTPRD binds IL1RAPL1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209536", "l": "IkB is ubiquitinated and degraded (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-383190", "l": "HCO3- transport through ion channel (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47322", "l": "3-oxo-3-phenylpropanoate + L-glutamate => (S)-3-amino-3-phenylpropanoate + 2-oxoglutarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451283", "l": "kainate receptor binds glutamate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46402", "l": "(25R)-cholest-5-ene-3beta,26-diol + H2O + 2 oxidized [adrenodoxin] => cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57056", "l": "D-apiofuranose + NAD(+) = D-apionolactone + H(+) + NADH"}, {"i": "EC:1.1.1.420", "l": "\"D-apiose dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27993", "l": "1-deoxy-D-xylulose + ATP <=> 1-deoxy-D-xylulose 5-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213246", "l": "Disassociation of CLIP from MHC II (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944262", "l": "Association of procollagen type X (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009036", "l": "type II site-specific deoxyribonuclease activity"}, {"i": "MetaCyc:3.1.21.4-RXN"}, {"i": "EC:3.1.21.4", "l": "\"Type II site-specific deoxyribonuclease\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682020", "l": "MRN complex binds shortened telomeres (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047202", "l": "sinapoylglucose-choline O-sinapoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34390", "l": "beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + UDP-alpha-D-galactofuranose <=> beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10710", "l": "diphosphate + GDP-D-glucose => alpha-D-glucose 1-phosphate + GTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48696", "l": "1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = H(+) + octanoate + octanoyl-3-(beta-D-galactosyl)-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49302", "l": "alpha-maltose 6'-phosphate(in) + L-histidyl-[protein] => D-maltose(out) + N(pros)-phospho-L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0016632", "l": "oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor"}, {"i": "EC:1.3.2.-", "l": "\"With a cytochrome as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373006", "l": "acetyl-CoA + H2O + oxaloacetate => citrate + CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592234", "l": "Expression of GABPA (NRF2 alpha subunit) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159868", "l": "Furin cleaves pro-factor VII to factor VII (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19521", "l": "acetyl-CoA + phosphate = acetyl phosphate + CoA"}, {"i": "EC:2.3.1.8", "l": "\"Phosphate acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.42", "l": "\"Atrolysin C\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2562526", "l": "PLK1 phosphorylates OPTN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28428", "l": "keto-D-fructose 6-phosphate => D-allulose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51557", "l": "(S)-glaucine + S-adenosyl-L-methionine => (S)-N-methylglaucine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047476", "l": "3-alpha,7-alpha-dihydroxy-5-beta-cholestanate-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2529020", "l": "CK2 phosphorylates condensin I subunits (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50709", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione => (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16539", "l": "(9S,10S)-9,10-dihydroxyoctadecanoate + phosphate => (9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.15", "l": "\"Malonate-semialdehyde dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45156", "l": "3-oxopropanoyl-CoA + H2O = 3-oxopropanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011983", "l": "Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168376", "l": "STIM1 oligomerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2509827", "l": "ITPA hydrolyses ITP to IMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64661", "l": "a long-chain fatty acid + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] => a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45840", "l": "(3R)-3-hydroxydecanoyl-CoA + NADP(+) = 3-oxodecanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203156", "l": "Platelet-derived TREM-1 ligand binds to TREM-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4090288", "l": "PIAS1,3 SUMOylate MBD1 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19453", "l": "2-oxoglutarate + L-alanine = L-glutamate + pyruvate"}, {"i": "EC:2.6.1.2", "l": "\"Alanine transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61769", "l": "rebaudioside A + UDP-alpha-D-glucose => H(+) + rebaudioside D + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614591", "l": "Excess cysteine yields lanthionine and H2S (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27365", "l": "bromide + S-adenosyl-L-methionine = bromomethane + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42199", "l": "(9Z)-heptadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-heptadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694563", "l": "ABHD10 hydrolyses MPAG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71515", "l": "glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37430", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate <=> a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66380", "l": "ATP + glutathione(in) + glycodeoxycholate(in) + H2O = ADP + glutathione(out) + glycodeoxycholate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295632", "l": "PPA2A dephosphorylates SPRY2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205306", "l": "Interaction of SHP1 and KIT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029453", "l": "Phosphorylation of VAV (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1299318", "l": "Activation of TASK (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210444", "l": "L-Glutamate loading of synaptic vesicle (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37501", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666001", "l": "Profilin:G-actin binds MKL1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877493", "l": "TNFRSF18 (GITR) gene expression is stimulated by FOXP3 and inhibited by RUNX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20525", "l": "ATP + ethylamine + L-glutamate = ADP + H(+) + N(5)-ethyl-L-glutamine + phosphate"}, {"i": "EC:6.3.1.6", "l": "\"Glutamate--ethylamine ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391211", "l": "Trace amine-associated receptors can bind trace amines (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48863", "l": "18-HEPE + O2 <=> (5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381087", "l": "Dimerization of PERK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31160", "l": "(3S)-hydroxyhexadecanoyl-CoA + NAD(+) => 3-oxohexadecanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25449", "l": "(2E,6E)-farnesyl diphosphate => (+)-guaia-6,9-diene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14352", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose <=> an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.17", "l": "\"Stromelysin 1\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59724", "l": "D-maltoheptaono-1,5-lactone + H2O = D-maltoheptaonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57645", "l": "(3-{(1R,2S,6S,8R)-2,8-dimethyl-3-[(E)-prop-1-enyl]-4,5-didehydrodecalin-2-yl}-3-oxopropanoyl)-[equisetin nonaketide synthase] + L-serine => H(+) + H2O + holo-[equisetin nonaketide synthase] + trichosetin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16947", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+) => (6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031805", "l": "type 8 metabotropic glutamate receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4341072", "l": "SUMOylation of RARA with SUMO2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935732", "l": "RUNX1 binds SIN3A,(SIN3B) co-repressor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109813", "l": "GRB2-1 binds SOS1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26450", "l": "CoA + NADP(+) + succinate semialdehyde = H(+) + NADPH + succinyl-CoA"}, {"i": "EC:1.2.1.76", "l": "\"Succinate-semialdehyde dehydrogenase (acetylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54055", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + tau-cadinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.37", "l": "\"Malate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29313", "l": "FMN + glyoxylate + 2 H(+) + H2O + sulfite => FMNH2 + O2 + sulfoacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66048", "l": "2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + 4-(2-aminophenyl)-2,4-dioxobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58151", "l": "ethyl acetate + H2O <=> acetate + ethanol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13261", "l": "2-methylbutanoyl-CoA + A = 2-methylbut-2-enoyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39931", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606784", "l": "Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018794", "l": "RHOV binds effectors at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50418", "l": "H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu) => L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49153", "l": "dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine => dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614614", "l": "Cysteine is degraded to serine and H2S (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36456", "l": "ATP + H2O + L-alanylglycine(out) => ADP + H(+) + L-alanylglycine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050562", "l": "lysine-tRNA(Pyl) ligase activity"}, {"i": "MetaCyc:6.1.1.25-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61386", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + H(+) + phosphate => 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47868", "l": "di-(9Z)-octadecenoylglycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004061", "l": "arylformamidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19475", "l": "3,4-dihydroxybenzoate + H2O + NAD(+) => 4-hydroxybenzoate + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222128", "l": "NOC2L binds TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625416", "l": "Anterograde IFT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003968", "l": "RNA-directed 5'-3' RNA polymerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981657", "l": "IL34 dimer binds PTPRZ1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "81.20444558259193", "identifiers": [{"i": "GO:0015114", "l": "phosphate ion transmembrane transporter activity"}, {"i": "RHEA:32823", "l": "phosphate(in) = phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419214", "l": "5'-phosphoribosyl-5-aminoimidazole (AIR) + CO2 <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785594", "l": "FANCD2 binds FANCI (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20040", "l": "D-sorbitol 6-phosphate + NADP(+) <=> aldehydo-D-glucose 6-phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12527", "l": "L-pipecolate + NADP(+) <=> Delta(1)-piperideine-2-carboxylate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0033549", "l": "MAP kinase phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944246", "l": "Association of procollagen type XXI (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51257", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate + O2 => (9S,16S)-dihydroperoxy-(10E,12Z,14E)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602603", "l": "IRAK4 deficiency blocks formation of the MyD88-IRAK4 Myddosome in the TLR5 pathway (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.65"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62511", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1237129", "l": "Acireductone is created (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-444100", "l": "PROT mediates L-proline uptake (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48295", "l": "ganglioside GM1 + GDP-beta-L-fucose <=> ganglioside Fuc-GM1 + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373711", "l": "DCC interaction with Netrin-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66830", "l": "2 adenosylcob(III)alamin + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate => 2 ATP + 2 cob(II)alamin + 2 H2O + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928597", "l": "EPH:EFN dimers tetramerise (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53383", "l": "5,6-dihydrouridine(16) in tRNA + NAD(+) <=> H(+) + NADH + uridine(16) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021944", "l": "MECP2 binds RBFOX1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59696", "l": "D-cellotetraono-1,5-lactone + H2O = D-cellotetraonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787737", "l": "CSF3R binds CSF3 dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32945", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+) => a 1,2-diacyl-sn-glycerol + CDP-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17443", "l": "2-oxo-3-sulfanylpropanoate + L-glutamate => 2-oxoglutarate + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373724", "l": "Nephrin binds NCK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10028", "l": "D-glutamate + H2O + O2 = 2-oxoglutarate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43093", "l": "S-adenosyl-L-methionine + uridine(2479) in 23S rRNA => 2'-O-methyluridine(2479) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23268", "l": "guanidinoacetate + H2O = glycine + urea"}, {"i": "EC:3.5.3.2", "l": "\"Guanidinoacetase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62208", "l": "3-methylphenol + O2 + reduced [NADPH--hemoprotein reductase] = 3-hydroxybenzyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11429", "l": "beta-D-glucose + O2 => D-glucono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0035596", "l": "methylthiotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871506", "l": "SORL1 transports APP(18-770) from endosome lumen to Golgi lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035642", "l": "histone methyltransferase activity (H3-R17 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65467", "l": "2-methylbutan-1-ol + butanoyl-CoA <=> 2-methylbutyl butanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450466", "l": "AUF1:mRNA complex is destroyed (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030794", "l": "(S)-coclaurine-N-methyltransferase activity"}, {"i": "RHEA:17409", "l": "(S)-coclaurine + S-adenosyl-L-methionine = (S)-N-methylcoclaurine + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.140", "l": "\"(S)-coclaurine-N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13418", "l": "5,12-dihydroxanthommatin + NAD(+) => H(+) + NADH + xanthommatin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36446", "l": "dihydrochanoclavine-I aldehyde <=> 6,8-dimethyl-6,7-didehydroergoline + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23980", "l": "cyclomaltodextrin + H2O = linear maltodextrin"}, {"i": "EC:3.2.1.54", "l": "\"Cyclomaltodextrinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33989", "l": "diphosphate + neoabietadiene => (+)-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16452", "l": "acetyl-CoA + kanamycin B <=> CoA + H(+) + N(6')-acetylkanamycin B"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070251", "l": "pristanate-CoA ligase activity"}, {"i": "REACT:R-HSA-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Homo sapiens)"}, {"i": "RHEA:47264", "l": "2,6,10,14-tetramethylpentadecanoate + ATP + CoA = AMP + diphosphate + pristanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798374", "l": "DYRK2 phosphorylates TP53 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693250", "l": "RHOD binds effectors at the Golgi membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11695", "l": "NAD(+) + NADPH <=> NADH + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex. (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36020", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209072", "l": "PLL kinase binds to TL:MYD88:TUB 'signalling complex' (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5678327", "l": "MIOX oxidises Ins to GlcA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004065", "l": "arylsulfatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047987", "l": "hydroperoxide dehydratase activity"}, {"i": "RHEA:25075", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694462", "l": "ABHD6,12 hydrolyse 3AG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203611", "l": "N-myristoylation of eNOS (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015229", "l": "L-ascorbic acid transmembrane transporter activity"}, {"i": "REACT:R-HSA-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39545", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+) => 3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52833", "l": "1-hydroxylimonen-2-one + H(+) + NADPH + O2 => 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32205", "l": "(4-hydroxyphenyl)acetaldehyde + methylamine => (R)-synephrine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.139"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863914", "l": "Transport of SEC22B, TAP and PLC from ER to ERGIC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042017", "l": "interleukin-22 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64113", "l": "an N-acyl-L-phenylalanine + H2O => a fatty acid + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622667", "l": "BBC3 gene expression is stimulated by FOXO3,(FOXO1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50037", "l": "choloyl-CoA + H2O => adenosine 3',5'-bisphosphate + choloyl-4'-phosphopantetheine + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60707", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine <=> a 1-acyl-sn-glycero-2,3-cyclic phosphate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13880", "l": "a 2-oxocarboxylate + L-ornithine <=> an L-alpha-amino acid + L-glutamate 5-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61717", "l": "ATP + D-galactofuranose(out) + H2O => ADP + D-galactofuranose(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353476", "l": "Recruitment of repair factors to form the preincision complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43563", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10994", "l": "glyoxylate + H(+) + NADPH => glycolate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034794", "l": "cyclopropanecarboxyl-CoA decyclase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56191", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36695", "l": "dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid = desmethyldescarbamoylnovobiocin + dTDP + H(+)"}, {"i": "EC:2.4.1.302", "l": "\"L-demethylnoviosyl transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186819", "l": "SH2 domain of Src binds to the active receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2545203", "l": "Deacetylation of cleaved cohesin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23055", "l": "ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] <=> ADP + H(+) + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033876", "l": "glycochenodeoxycholate sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389970", "l": "Actin/tubulin:prefoldin complex associates with CCT/TriC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623705", "l": "Defective SLC12A3 does not cotransport Cl-, Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20159", "l": "2n [Fe(II)cytochrome c] + an oxidized polyvinyl alcohol + 2n H(+) => 2n [Fe(III)cytochrome c] + a polyvinyl alcohol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047869", "l": "dimethylpropiothetin dethiomethylase activity"}, {"i": "MetaCyc:DIMETHYLPROPIOTHETIN-DETHIOMETHYLASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38395", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O = (9Z)-hexadecenoate + 1,3-di-(9Z)-hexadecenoylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66826", "l": "2 adenosylcob(III)inamide + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate => 2 ATP + 2 cob(II)inamide + 2 H2O + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043875", "l": "2-ketobutyrate formate-lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-984606", "l": "Kinesin-5 is a homotetramer (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212356", "l": "Formation of CSL-NICD coactivator complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031719", "l": "type 2 cannabinoid receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694447", "l": "mRNA2 is translated to Spike (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389974", "l": "Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C-> Beta-tubulin:GDP :alpha-tubulin:GTP heterodimer +Cofactor E+ Cofactor D+ Cofactor C+ Pi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66171", "l": "[protein]-with a C-terminal TM segment(out) + ATP + H2O <=> [protein]-with a C-terminal TM segment(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047896", "l": "formaldehyde transketolase activity"}, {"i": "RHEA:24264", "l": "D-xylulose 5-phosphate + formaldehyde = D-glyceraldehyde 3-phosphate + dihydroxyacetone"}, {"i": "EC:2.2.1.3", "l": "\"Formaldehyde transketolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803761", "l": "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788628", "l": "p-Y-STATs dissociate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000074", "l": "TCII binds Cbl in the circulation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35495", "l": "H2O + N-(4-aminobenzoyl)-L-glutamate = 4-aminobenzoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50806", "l": "prostaglandin J2-S-(R)-glutathione => glutathione + prostaglandin J2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264997", "l": "Oxidation of cysteine to cystine in Proinsulin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66763", "l": "ATP + H2O + kainate(in) <=> ADP + H(+) + kainate(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69053", "l": "RFC binding displaces Pol Alpha (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9035227", "l": "TXN2 binds CysS248-MPST (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39541", "l": "(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+) => (2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175177", "l": "Association of  XRCC4:DNA ligase IV complex with viral DNA ends (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806629", "l": "Formation of tonofilament bundles (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65237", "l": "3-methylbutanol + acetyl-CoA => 3-methylbutyl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11407", "l": "UDP-alpha-D-glucuronate <=> UDP-alpha-D-galacturonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58283", "l": "4 ATP <=> cyclic tetraadenylate + 4 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18101", "l": "cis-1,2-dihydro-3-ethylcatechol + NAD(+) = 3-ethylcatechol + H(+) + NADH"}, {"i": "EC:1.3.1.66", "l": "\"Cis-dihydroethylcatechol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33250", "l": "O2 + putrescine <=> 1-pyrroline + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44469", "l": "3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167150", "l": "Resumption of elongation of HIV-1 transcript after recovery from pausing (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11902", "l": "2-oxoadipate + CO2 + NADH => (1R,2S)-homoisocitrate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11510", "l": "3-hydroxy-L-aspartyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-aspartyl-[protein] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68849", "l": "Mcm2-7 associates with the Cdt1:CDC6:ORC:origin complex, forming the pre-replicative complex (preRC) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40802", "l": "2-methylpropanoyl-CoA + H2O <=> 2-methylpropanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709842", "l": "MAVS binds TOMM70 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-372542", "l": "Loading of dopamine into synaptic veiscles (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856157", "l": "LAG3 (CD233) binds MHC II (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1306876", "l": "NLRP3 activation by small molecules (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5671737", "l": "p-T774-PKN1 binds CDC25C (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004561", "l": "alpha-N-acetylglucosaminidase activity"}, {"i": "REACT:R-HSA-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161293", "l": "Tropoelastin forms aggregate globules (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40396", "l": "1,2-dihydro-beta-NAD + H(+) + O2 => H2O2 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46488", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43291", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37022", "l": "A + D-serine + H2O <=> 3-hydroxypyruvate + AH2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63996", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1467466", "l": "ABCA4 mediates atRAL transport (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080025", "l": "phosphatidylinositol-3,5-bisphosphate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933532", "l": "Processing of caspases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49151", "l": "dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine <=> dTDP-alpha-D-forosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611158", "l": "Fusion of HCMV Envelope with Plasma Membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29958", "l": "H(+)(in) + thymidine(in) <=> H(+)(out) + thymidine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050013", "l": "2-dehydropantoate aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216045", "l": "Collagen type I binds integrin alpha11beta1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31446", "l": "ATP + D-sedoheptulose 7-phosphate <=> ADP + H(+) + sedoheptulose 1,7-bisphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008675", "l": "2-dehydro-3-deoxy-phosphogluconate aldolase activity"}, {"i": "EC:4.1.2.14", "l": "\"2-dehydro-3-deoxy-phosphogluconate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32036", "l": "(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O => (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876472", "l": "NPC2 binds CHOL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708557", "l": "FBXL17 binds BACH1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990841", "l": "promoter-specific chromatin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9626848", "l": "S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867613", "l": "PICALM binds R-SNAREs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29365", "l": "2'-deoxycytidine + phosphate => dCMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43905", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol => all-trans-retinyl hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791108", "l": "Expression of SULT1A3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102574", "l": "3-oxo-myristoyl-ACP hydrolase activity"}, {"i": "MetaCyc:RXN-15280"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62214", "l": "gentisyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-hydroxybenzyl alcohol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783455", "l": "TYW5 hydroxylates yW-72 yielding OHyW-72 at nucleotide 37 of tRNA(Phe) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807008", "l": "PTPRJ dephosphorylates MET (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578965", "l": "TNRC6A binds AGO2:miRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2288097", "l": "Condensin II complex binds H4K20me1-containing nucleosomes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0030551", "l": "cyclic nucleotide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36128", "l": "gibberellin A34 + S-adenosyl-L-methionine => O-methyl gibberellin A34 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27313", "l": "naphthalene-1,2-diol + O2 <=> 2-hydroxychromene-2-carboxylate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52278", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4-dihydroxybenzoate => (6S)-5,6,7,8-tetrahydrofolate + 4-hydroxy-3-methoxybenzoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19972", "l": "hydroxylamine + O2 <=> H(+) + H2O + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54162", "l": "[ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875558", "l": "RAPGEF1 binds CRK,CRKL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23606", "l": "H2O + kievitone => kievitone hydrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36789", "l": "N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0008251", "l": "tRNA-specific adenosine deaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55342", "l": "1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862280", "l": "FCHo proteins bind nascent clathrin-coated pit (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24570", "l": "an alcohol + D-galactose 6-phosphate => a 6-phospho-beta-D-galactoside + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018781", "l": "S-triazine hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928639", "l": "p-EFNB binds GRB4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43007", "l": "H(+) + O-carbamoyl-L-serine <=> 2-aminoprop-2-enoate + CO2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22751", "l": "4-hydroxy-4-methyl-2-oxoglutarate <=> 2 pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191303", "l": "FDPS dimer transfers IPPP to GPP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196017", "l": "Dynamin is recruited to the gap junction plaque (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45171", "l": "2 (E)-sinapoyl-CoA + spermidine <=> 2 CoA + 2 H(+) + N(1),N(8)-bis[(E)-sinapoyl]-spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40845", "l": "(2E)-octadecenoyl-CoA + FADH2 => FAD + H(+) + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033886", "l": "cellulose-polysulfatase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102787", "l": "caffeoyl-CoA:pelargonidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity"}, {"i": "MetaCyc:RXN-7997"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.34"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102223", "l": "4,4'-diapophytoene desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166362", "l": "Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-9637589", "l": "MmpL7 transports PDIM from the cytosol to the cell wall (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102777", "l": "caffeoyl-CoA:pelargonidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity"}, {"i": "MetaCyc:RXN-7842"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627350", "l": "SMAC (DIABLO) binds XIAP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43144", "l": "adenosine(22) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.217", "l": "\"tRNA (adenine(22)-N(1))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38571", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52211", "l": "alachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + methyl formate + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75244", "l": "FASL binds FAS Receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40284", "l": "(R)-carnitine + hexadecanedioyl-CoA => CoA + O-hexadecanedioyl-L-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19212", "l": "codeine + NADP(+) <=> codeinone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662613", "l": "MT3 exchanges zinc for copper (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42764", "l": "formate + 2 H(+) + oxidized coenzyme F420-(gamma-Glu)(n) = CO2 + reduced coenzyme F420-(gamma-Glu)(n)"}, {"i": "EC:1.17.98.3", "l": "\"Formate dehydrogenase (coenzyme F420)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814831", "l": "TBC1D20 binds RAB1:GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376851", "l": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14314", "l": "2-iodophenol + S-adenosyl-L-methionine => 1-iodo-2-methoxybenzene + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49924", "l": "(R)-carnitine(out) + O-acyl-(R)-carnitine(in) = (R)-carnitine(in) + O-acyl-(R)-carnitine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46217", "l": "H(+) + NADPH + progesterone => 3beta-hydroxypregn-4-ene-20-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44023", "l": "H2O + NAD(+) + octadecanal <=> 2 H(+) + NADH + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65235", "l": "3-hydroxydodecanoyl-CoA + H2O <=> 3-hydroxydodecanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62402", "l": "(S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH => (1R,2S)-ephedrine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29515", "l": "beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)"}, {"i": "EC:2.4.1.132", "l": "\"GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10397", "l": "an L-alpha-amino acid + H2O + NAD(+) => a 2-oxocarboxylate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191072", "l": "Synthesis of Cx43 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11283", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dCMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-437139", "l": "ZnT6 transports zinc into the golgi apparatus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003952", "l": "NAD+ synthase (glutamine-hydrolyzing) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50925", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 => (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16233", "l": "(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH"}, {"i": "EC:1.1.1.169", "l": "\"2-dehydropantoate 2-reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56510", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48726", "l": "3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide => aurachin B + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675198", "l": "Activated MAPKs phosphorylate BRAF (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198563", "l": "IDO1 dioxygenates L-Trp to NFK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052862", "l": "glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140661", "l": "cytoskeletal motor inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57367", "l": "H2O + NADH <=> (6S)-NADHX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.4.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59839", "l": "H2O + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein] <=> 3-deoxyglucosone + L-lysyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36319", "l": "2 H(+) + 2 NADPH + octadecanoyl-CoA = CoA + 2 NADP(+) + octadecan-1-ol"}, {"i": "EC:1.2.1.84", "l": "\"Alcohol-forming fatty acyl-CoA reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809521", "l": "BPIF binds bacteria (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43069", "l": "beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19643", "l": "(E)-4-coumaroyl-CoA + AMP + diphosphate => (E)-4-coumarate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17740", "l": "NADP(+) + shikimate <=> 3-dehydroshikimate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31476", "l": "soyasapogenol B + UDP-alpha-D-glucuronate => H(+) + soyasapogenol B 3-O-beta-D-glucuronate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0140659", "l": "cytoskeletal motor regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10004", "l": "benzyl isothiocyanate = benzyl thiocyanate"}, {"i": "EC:5.99.1.1", "l": "\"Thiocyanate isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50119", "l": "eicosanoyl-CoA + taurine <=> CoA + H(+) + N-eicosanoyl-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55922", "l": "(4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal + cis-1,4-isoprene(n-3) => [cis-1,4-isoprene](n) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852010", "l": "BTNL2 binds activated T cells surface (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25162", "l": "L-glutamate + L-glutamate 5-semialdehyde => 2-oxoglutarate + L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34091", "l": "(5R)-5-phosphooxy-L-lysine + H2O = (S)-2-amino-6-oxohexanoate + NH4(+) + phosphate"}, {"i": "EC:4.2.3.134", "l": "\"5-phosphooxy-L-lysine phospho-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043866", "l": "adenylyl-sulfate reductase (thioredoxin) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52738", "l": "adenosine 3',5'-bisphosphate + glucobrassicin + H(+) => 3'-phosphoadenylyl sulfate + indolylmethyl-desulfoglucosinolate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047831", "l": "D-ornithine 4,5-aminomutase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034833", "l": "geranylate CoA-transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58262", "l": "ADP-D-ribose + L-tyrosyl-[protein] => H2O + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853762", "l": "RET dimerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48797", "l": "O2 + prostaglandin H1 + reduced [NADPH--hemoprotein reductase] => 19-hydroxyprostaglandin H1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52070", "l": "(9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+) => 9-(9Z-hexadecenoyloxy)-octadecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39855", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycerol = a triacyl-sn-glycerol + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42542", "l": "pseudouridine(13) in tRNA => uridine(13) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11983", "l": "2 L-gamma-glutamyl-L-cysteine + NADP(+) <=> bis-gamma-glutamylcystine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111238", "l": "Formation of ADAR2  homodimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34528", "l": "L-phenylalanine => (S)-3-amino-3-phenylpropanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75244", "l": "FASL binds FAS Receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23529", "l": "citramalate + succinyl-CoA => citramalyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.378", "l": "\"L-rhamnose 1-dehydrogenase (NAD(P)(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23702", "l": "(6S)-10-formyltetrahydrofolate + H(+) => 5,10-methenyltetrahydrofolate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25510", "l": "(1S,5S)-sabinene + diphosphate => (2E)-geranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47479", "l": "(3E)-tetradecenoyl-CoA <=> (2E)-tetradecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001968", "l": "fibronectin binding"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0016503", "l": "pheromone receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41427", "l": "2 3-amino-4-hydroxybenzaldehyde + N-acetyl-L-cysteine + 2 O2 <=> formate + grixazone A + H(+) + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693061", "l": "STAMBP binds STAM (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848751", "l": "PTK6 binds AKT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41150", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163549", "l": "phosphorylated HSL dimer + FABP4 -> phosphorylated HSL dimer:FABP4 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1362416", "l": "Frataxin binds iron (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534378", "l": "Hv1 Mediated H+ Permeability (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030975", "l": "thiamine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2002440", "l": "Removal of fibrillar collagen C-propeptides (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48732", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O = [CysO sulfur-carrier protein]-C-terminal Gly-Gly + H(+) + L-cysteine"}, {"i": "EC:3.13.1.6", "l": "\"[CysO sulfur-carrier protein]-S-L-cysteine hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419861", "l": "Melanospin is stimulated by light (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52743", "l": "glyphosate + H2O + O2 <=> aminomethylphosphonate + glyoxylate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18354", "l": "ATP + H2O + K(+)(out) + Na(+)(in) => ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029454", "l": "Autophosphorylation of PAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980130", "l": "NOTCH1 binds DLK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15756", "l": "GTP + IMP + L-aspartate <=> GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210277", "l": "Interaction of PECAM-1 and SHP-1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696960", "l": "USP49 deubiquitinates H2B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682992", "l": "KDM4A,B bind H4K20Me2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57250", "l": "dGTP + glycolate + H(+) => H2O + N(2)-(1-hydroxy-2-oxoethyl)-dGTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31257", "l": "3-hydroxy-3-methyl-2-oxobutanoate => (2S)-2-acetolactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944223", "l": "Association of procollagen type V (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044729", "l": "hemi-methylated DNA-binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449087", "l": "CD4 binds Interleukin-16 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45572", "l": "[(1->4)-beta-D-mannuronosyl](n) = [alginate](n)"}, {"i": "EC:5.1.3.37", "l": "\"Mannuronan 5-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10731", "l": "GDP-6-deoxy-alpha-D-talose + NAD(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9731924", "l": "EDNRA binds EDNs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44580", "l": "4-hydroxy-3-all-trans-decaprenylbenzoate + H(+) = 2-all-trans-decaprenylphenol + CO2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019781", "l": "NEDD8 activating enzyme activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33562", "l": "an acyl-CoA + sn-glycerol 3-phosphate <=> a 2-acyl-sn-glycerol 3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66209", "l": "(8R)-8-hydroxynonanoyl-CoA + O2 => (2E,8R)-8-hydroxynonenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19313", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+)"}, {"i": "EC:2.4.99.8", "l": "\"Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034803", "l": "3-hydroxy-2-naphthoate 2,3-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29050", "l": "a menaquinone + 2 H(+)(in) + H2 <=> a menaquinol + 2 H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205321", "l": "Interaction of KIT and sSCF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0140035", "l": "ubiquitination-like modification-dependent protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382053", "l": "Translocation of PDGF from ER to Golgi (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27920", "l": "2 H(+) + NADPH + propanoate => H2O + NADP(+) + propanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27827", "l": "hydrogen sulfide + O-succinyl-L-homoserine => L-homocysteine + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47610", "l": "3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA => 3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106363", "l": "protein-cysteine methyltransferase activity"}, {"i": "RHEA:66544", "l": "L-cysteinyl-[protein] + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668467", "l": "2xTNFR2 binds TNFA trimer:TNFR2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200646", "l": "Cytosolic folate export across the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59537", "l": "ATP + butanoyl-CoA + hydrogencarbonate => (2R)-ethylmalonyl-CoA + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64643", "l": "H2O + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose <=> lactose + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40610", "l": "1-tetradecanoyl-sn-glycerol + H2O <=> glycerol + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1236970", "l": "Proteasomal clevage of exogenous antigen (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20792", "l": "ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)"}, {"i": "EC:6.1.1.6", "l": "\"Lysine--tRNA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13022", "l": "4-hydroxy-3-methoxybenzoate + H(+) + NADH + O2 => 3,4-dihydroxybenzoate + formaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42302", "l": "a 1-acyl-sn-glycero-3-phosphate + holo-[ACP] => a fatty acyl-[ACP] + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25301", "l": "acetaldehyde + H2O + NADP(+) <=> acetate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43210", "l": "5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine => carboxymethyluridine(34) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085347", "l": "PIAS1 SUMOylates SAFB with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061657", "l": "UFM1 conjugating enzyme activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229283", "l": "LCNs bind lipids (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51826", "l": "AMP(in) + diphosphate(in) + H(+)(in) + octanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + octanoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950778", "l": "p-Y693-STAT4 dimerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22314", "l": "ADP + H(+) + S-methyl-5-thio-alpha-D-ribose 1-phosphate => 5-(methylsulfanyl)-D-ribose + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.14"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853745", "l": "RET binds GFRA1,GFRA3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784204", "l": "JAKs bind OSMR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60278", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37256", "l": "A + D-asparagine + H2O => 2-oxosuccinamate + AH2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52884", "l": "H2O + N-phenylhydroxylamine + 2 NADP(+) = 2 H(+) + 2 NADPH + nitrobenzene"}, {"i": "EC:1.7.1.16", "l": "\"Nitrobenzene nitroreductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368889", "l": "Expression of NAMPT (NamPRT, PBEF, Visfatin) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205117", "l": "p75NTR:NADE promotes caspase2/3 activation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3095889", "l": "MMACHC reduces Cbl (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004622", "l": "lysophospholipase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63573", "l": "H2O + neurotensin-(1-8) => L-arginine + neurotensin-(1-7)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018071", "l": "NAD(P)-cysteine ADP-ribosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16347", "l": "(3E,7E)-dolabella-3,7-dien-18-ol + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48161", "l": "3 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] => epoxypheophorbide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14704", "l": "2 CoA + NAD(+) <=> CoA-disulfide + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700149", "l": "Active ALK binds PLCG1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209960", "l": "Diiodinated tyrosine can be deiodinated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32776", "l": "(2-aminoethyl)phosphonate(out) + ATP + H2O => (2-aminoethyl)phosphonate(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30269", "l": "L-ascorbate + L-dehydroascorbate => 2 monodehydro-L-ascorbate radical"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22625", "l": "(S)-4-hydroxy-2-oxopentanoate => acetaldehyde + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854462", "l": "VLDLR binds VLDL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428515", "l": "Recruitment of SOS to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43389", "l": "1D-myo-inositol 3,4-bisphosphate + H2O => 1D-myo-inositol 3-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33415", "l": "bornane-2,6-dione + H2O = [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate + H(+)"}, {"i": "EC:3.7.1.18", "l": "\"6-oxocamphor hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204500", "l": "CyP60 chaperones Basigin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928597", "l": "EPH:EFN dimers tetramerise (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5658430", "l": "NF1 is degraded by the proteasome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047454", "l": "phaseollidin hydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380294", "l": "Loss of C-Nap-1 from centrosomes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351913", "l": "Caspase-mediated cleavage of TJP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693536", "l": "ATM phosphorylates MDC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50081", "l": "ATP + H2O + taurodeoxycholate(in) => ADP + H(+) + phosphate + taurodeoxycholate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617828", "l": "TRIP11:IFT20 dissociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682026", "l": "MRN bound to shortened telomeres activates ATM (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40160", "l": "H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => NAD(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114544", "l": "p115-RhoGEF activation of RHOA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33315", "l": "a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31510", "l": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine <=> H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63036", "l": "H2O + octadecanamide = NH4(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913374", "l": "Phosphorylated SHC1 recruits SHIP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58526", "l": "(16S)-deshydroxymethyl-stemmadenine + formate + NADP(+) => 15alpha-stemmadenine intermediate I + H2O + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65959", "l": "ATP + estrone 3-sulfate(out) + H2O <=> ADP + estrone 3-sulfate(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381087", "l": "Dimerization of PERK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070888", "l": "E-box binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44542", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2317314", "l": "AKT binds PDPK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111883", "l": "Hydrolysis of phosphatidylcholine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9029690", "l": "Caspase-6 translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59213", "l": "holo-[(hydroxy)phthioceranic acid synthase] + octadecanoyl-AMP => AMP + H(+) + octadecanoyl-[(hydroxy)phthioceranic acid synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798044", "l": "BTG2 binds CCR4-NOT complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13789", "l": "[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59468", "l": "an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164503", "l": "First strand transfer mediated by Repeated (R) sequence (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34377", "l": "4-guanidinobutanoate + NH4(+) => 4-guanidinobutanamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12491", "l": "2-amino-2-deoxy-D-gluconate <=> 2-dehydro-3-deoxy-D-gluconate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2129362", "l": "Fibrillin microfibril assembly (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48209", "l": "H(+) + nonanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372819", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24412", "l": "4-(hydroxymethyl)benzenesulfonate + NAD(+) = 4-formylbenzenesulfonate + H(+) + NADH"}, {"i": "EC:1.1.1.257", "l": "\"4-(hydroxymethyl)benzenesulfonate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44855", "l": "(5Z)-tetradecenoyl-CoA + (R)-carnitine <=> CoA + O-(5Z)-tetradecenoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54639", "l": "(13E)-labda-7,13-dien-15-yl diphosphate <=> diphosphate + labda-7,13(16),14-triene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29499", "l": "(2E,6E)-farnesyl diphosphate = (+)-alpha-barbatene + diphosphate"}, {"i": "EC:4.2.3.69", "l": "\"(+)-alpha-barbatene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358789", "l": "Self-ubiquitination of RNF41 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29235", "l": "a menaquinone + H(+) + NADH = a menaquinol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010277", "l": "chlorophyllide a oxygenase [overall] activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371385", "l": "TNF-alpha is cleaved by ADAM17 (TACE) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66690", "l": "(4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + A + acetone + H(+) + H2O => 4-farnesyl-3,5-dihydroxy-6-methylphthalide + AH2 + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-688985", "l": "K63 polyubiquitinated RIP2 associates with the TAK1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018746", "l": "phenanthrene-3,4-epoxide hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675198", "l": "Activated MAPKs phosphorylate BRAF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614544", "l": "Sulfite is oxidized to sulfate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9749197", "l": "ORC1 binds to H4K20me2 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31703", "l": "2 H(+) + O2 + pentalenene + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60904", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = 13-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20755", "l": "A + 2 cob(II)alamin + 2 H(+) + 2 H2O <=> AH2 + 2 aquacob(III)alamin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551453", "l": "PRKG is activated by binding to high levels of cGMP in the absence of WNT signaling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51765", "l": "dimethylallyl diphosphate + phlorisovalerophenone => 4-prenylphlorisovalerophenone + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42522", "l": "pseudouridine(2605) in 23S rRNA => uridine(2605) in 23S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070967", "l": "coenzyme F420 binding"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0005184", "l": "neuropeptide hormone activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33505", "l": "ADP + H(+) + itraconazole(out) + phosphate => ATP + H2O + itraconazole(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004304", "l": "estrone sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990424", "l": "protein arginine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.3.-", "l": "\"Linked to the hydrolysis of diphosphate\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24245", "l": "NADP(+) + pseudotropine => H(+) + NADPH + tropinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-444433", "l": "Cho transports from the extracellular space to the cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13613", "l": "beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate"}, {"i": "EC:2.7.1.90", "l": "\"Diphosphate--fructose-6-phosphate 1-phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.36"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17842", "l": "trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854981", "l": "SHC1 in the RET complex is phosphorylated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22007", "l": "ATP + L-seryl-[myosin light chain] <=> ADP + H(+) + O-phospho-L-seryl-[myosin light chain]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685318", "l": "BCDX2 complex formation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5221061", "l": "TDG excises 5-carboxylcytosine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43185", "l": "S-adenosyl-L-methionine + uridine(2843) in 25S rRNA => H(+) + N(3)-methyluridine(2843) in 25S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018754", "l": "GDIs bind RHOH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112436", "l": "Formation of Elongin complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29394", "l": "GTP + H2O <=> diphosphate + GMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047887", "l": "farnesyl diphosphate kinase activity"}, {"i": "RHEA:21544", "l": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP"}, {"i": "EC:2.7.4.18", "l": "\"Farnesyl-diphosphate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936676", "l": "Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864029", "l": "PTPN12 dephosphorylates EGFR at Y1148 (Y1172) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102528", "l": "7,8,4'-trihydroxyflavone methyltransferase activity"}, {"i": "MetaCyc:RXN-14658"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009936", "l": "RNASEL cleaves cellular ssRNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730903", "l": "Oligomerization of TRAF6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210294", "l": "Interaction of PECAM-1 and SHP-2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14027", "l": "NH4(+) + xanthopterin-B2 => H(+) + H2O + sepiapterin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045127", "l": "N-acetylglucosamine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749197", "l": "ORC1 binds to H4K20me2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507875", "l": "Aquaporins passively transport urea into cells (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374675", "l": "L1 dimer binds Ankyrin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811508", "l": "ING2-bound EP300 acetylates TP53 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.16", "l": "\"tRNA-intron lyase\""}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0022858", "l": "alanine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.19"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080070", "l": "8-methylthiooctyl-desulfoglucosinolate sulfotransferase activity"}, {"i": "MetaCyc:RXNQT-4333"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419841", "l": "Light stimulates opsin receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.32", "l": "\"Cullin-RING-type E3 NEDD8 transferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052828", "l": "inositol-3,4-bisphosphate 4-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617815", "l": "BBSome binds RAB3IP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32584", "l": "dihydrocarvone + H(+) + NADPH + O2 => 6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29413", "l": "glycolate(out) + H(+)(out) => glycolate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30591", "l": "H2O + O2 + tyramine = (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917730", "l": "Cargo Recognition And Sorting (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851038", "l": "BTN3A1 binds prenylated phosphoantigens (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76416", "l": "Benzene is hydroxylated to phenol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57347", "l": "3-hydroxy-D-kynurenine + S-adenosyl-L-methionine <=> 3-hydroxy-4-methyl-D-kynurenine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592436", "l": "Initial activation of proMMP9 by MMPs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51555", "l": "D-sorbitol + NADP(+) <=> H(+) + L-xylo-3-hexulose + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352268", "l": "Cleavage of Satb1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018756", "l": "RHOH binds GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25009", "l": "N-hydroxy-L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30079", "l": "ATP + CoA + crotonobetaine = AMP + crotonobetainyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012671", "l": "p-STAT5 binds CISH, SOCS1 and SOCS2 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48572", "l": "3,5-dichlorocatechol + O2 = (2E,4E)-2,4-dichloromuconate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805730", "l": "SETD9 methylates TP53 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0002161", "l": "aminoacyl-tRNA editing activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16265", "l": "O2 + reduced [NADPH--hemoprotein reductase] + trans-5-O-(4-coumaroyl)-D-quinate = 5-O-[(E)-caffeoyl]-D-quinate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.96", "l": "\"5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32930", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> a 1,2-diacyl-sn-glycerol + H(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977363", "l": "Factor H binds to C3bBb (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2870221", "l": "E-selectin binds E-selectin ligand (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862771", "l": "PLA2G2A binds bacterial phospholipids (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60866", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047358", "l": "UDP-glucose-glycoprotein glucose phosphotransferase activity"}, {"i": "RHEA:20181", "l": "alpha-D-mannose derivative + UDP-alpha-D-glucose = 6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H(+) + UMP"}, {"i": "EC:2.7.8.19", "l": "\"UDP-glucose--glycoprotein glucose phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54506", "l": "beta-hexaprene + diphosphate => all-trans-hexaprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-156661", "l": "Formation of Exon Junction Complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32466", "l": "glycine + 2 S-adenosyl-L-methionine <=> 2 H(+) + N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102678", "l": "22-alpha-hydroxy-campest-4-en-3-one,NADPH:steroid 5alpha-reductase activity"}, {"i": "MetaCyc:RXN-4229"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8955844", "l": "RBKS phosphorylates ribose to R5P (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32564", "l": "(2E)-geranyl diphosphate => alpha-terpinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41198", "l": "1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.-", "l": "\"Forming phosphoric ester bonds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18280", "l": "a thiol + S-adenosyl-L-methionine <=> a methyl thioether + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28737", "l": "H(+)(out) + spermidine(in) => H(+)(in) + spermidine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16254", "l": "(3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) => H(+) + NADH + phenanthrene-3,4-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16477", "l": "NAD(+) + prostaglandin E1 = 15-oxoprostaglandin E1 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665286", "l": "Resistant ERBB2 KD mutants do not bind neratinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990189", "l": "peptide-serine-N-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41073", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51717", "l": "ATP(in) + CoA(in) + H(+)(out) + hexadecanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + hexadecanoyl-CoA(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31114", "l": "acetyl-CoA + butanoyl-CoA <=> 3-oxohexanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972968", "l": "SALL4 binds the SALL4 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.69"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1218824", "l": "HSP90 is inactivated by binding to benzaquinoid ansamycins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047050", "l": "(S)-2-hydroxy-fatty acid dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18934", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA => (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49035", "l": "(-)-4'-desmethyl-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] <=> 4'-demethylepipodophyllotoxin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57603", "l": "2 [Fe(II)-cytochrome b5] + a 1-hexacosanoyl-2-acyl-phosphoglycerolipid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a 1-[(17Z)-hexacos-17-enoyl]-2-acyl-phosphoglycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030627", "l": "pre-mRNA 5'-splice site binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427336", "l": "TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9. (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62666", "l": "deoxyherqueinone + H(+) + S-adenosyl-L-homocysteine => (2'R)-atrovenetin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160874", "l": "HYAL1 hydrolyses (HA)50 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64370", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 AH2 => 2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.90", "l": "\"tRNA-dihydrouridine(20a/20b) synthase (NAD(P)(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46888", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + O2 = 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + H2O2"}, {"i": "EC:1.1.3.48", "l": "\"3-deoxy-alpha-D-manno-octulosonate 8-oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21338", "l": "4-pyridoxolactone + H(+) + NADH => NAD(+) + pyridoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52054", "l": "9-hydroxy-octadecanoate + H(+) + hexadecanoate => 9-hexadecanoyloxy-octadecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22626", "l": "acetaldehyde + pyruvate => (S)-4-hydroxy-2-oxopentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70899", "l": "histidine => urocanate + NH4+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42331", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044549", "l": "GTP cyclohydrolase binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010429", "l": "methyl-CpNpN binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59035", "l": "(Z)-24-ethylidenelophenol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52826", "l": "(4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => (1R,4R)-dihydrocarvone + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33956", "l": "DIBOA + UDP-alpha-D-glucose => DIBOA beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.3.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635996", "l": "NEIL3 resolves psoralen-induced ICLs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651773", "l": "LIG1 binds POLB at long-patch BER site (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22290", "l": "an N-acyl-sphingoid base + an oligoglycosyl-(1->4)-D-glucose => an oligoglycosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36593", "l": "2-chloroacrylate + H(+) + NADPH => (S)-2-chloropropanoate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730841", "l": "Phosphorylation and activation of VAV (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28264", "l": "3-O-(6-O-alpha-D-xylosylphospho-alpha-D-mannopyranosyl)-alpha-D-mannopyranose + H(+) + UMP => 3-alpha-D-mannopyranosyl-alpha-D-mannopyranose + UDP-alpha-D-xylose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678998", "l": "Endosomal TLRs pass through the Golgi (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23110", "l": "D-arabinonate + H(+) => D-arabinono-1,4-lactone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24391", "l": "phosphate + uridine <=> alpha-D-ribose 1-phosphate + uracil"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592316", "l": "Initial activation of proMMP1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66340", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) + ATP + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59353", "l": "beta-lactose + O2 => H2O2 + lactobiono-1,5-lactone"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030267", "l": "glyoxylate reductase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54097", "l": "N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42567", "l": "uridine(38/39) in tRNA <=> pseudouridine(38/39) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45155", "l": "3-hydroxy-3-(methylsulfanyl)propanoyl-CoA <=> 3-oxopropanoyl-CoA + methanethiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681651", "l": "nsp8 generates RNA primers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617486", "l": "HOXB2 gene is transcribed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15520", "l": "H2O + N(2),6-disulfo-D-glucosamine <=> H(+) + N-sulfo-D-glucosamine + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57943", "l": "Fe-coproporphyrin III + H(+) + H2O2 <=> CO2 + 2 H2O + harderoheme III"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18792", "l": "D-glucosamine 6-phosphate <=> D-galactosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033191", "l": "macrophomate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043828", "l": "tRNA 2-selenouridine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72095", "l": "Internal Methylation of mRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050230", "l": "purine imidazole-ring cyclase activity"}, {"i": "MetaCyc:PURINE-IMIDAZOLE-RING-CYCLASE-RXN"}, {"i": "EC:4.3.2.4", "l": "\"Purine imidazole-ring cyclase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64894", "l": "AMP + H(+) + tetradecanoyl-[ACP] => holo-[ACP] + tetradecanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010174", "l": "nucleoside transmembrane transporter activity, against a concentration gradient"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2247513", "l": "STAB1:ligand is endocytosed (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381545", "l": "Formation of the IGF:IGFBP5:ALS complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49356", "l": "2'-hydroxy-2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2',2'-dihydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031299", "l": "taurine-pyruvate aminotransferase activity"}, {"i": "MetaCyc:TAURINE-AMINOTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.35"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-947499", "l": "Exchange of oxygen with sulfur in MoCo (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9005980", "l": "IL21 binds IL21R:JAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30533", "l": "biotin + H2O + NAD(+) => biotinate sulfoxide + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19173", "l": "H(+) + NADH + naphthalene + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)"}, {"i": "EC:1.14.12.12", "l": "\"Naphthalene 1,2-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.-.-", "l": "\"Glycosyltransferases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878914", "l": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8934446", "l": "Activated PKC phosphorylates SHC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004639", "l": "phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033296", "l": "rhamnose binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102400", "l": "dTDP-3-amino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N,N-dimethyltransferase activity"}, {"i": "MetaCyc:RXN-13667"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51845", "l": "(9Z)-hexadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) => (9Z)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621352", "l": "CLEC6A binds alpha-mannan in fungal cell walls (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41200", "l": "1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57525", "l": "a 5'-triphospho-guanosine-ribonucleotide-tRNA(His) + H2O => a 5'-phospho-guanosine-ribonucleotide-tRNA(His) + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53845", "l": "glycochenodeoxycholate + NAD(+) => 7-oxoglycolithocholate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023840", "l": "HATs and coactivators are recruited to the CTSD gene (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030628", "l": "pre-mRNA 3'-splice site binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633314", "l": "TP53 stimulates NDRG1 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806629", "l": "Formation of tonofilament bundles (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47284", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64822", "l": "2-phenylacetate + NH4(+) => 2-phenylacetamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0047267", "l": "undecaprenyl-phosphate mannosyltransferase activity"}, {"i": "EC:2.4.1.54", "l": "\"Undecaprenyl-phosphate mannosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8856951", "l": "PP2A demethylation by PPME1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11344", "l": "an N-acylneuraminate + CTP = a CMP-N-acyl-beta-neuraminate + diphosphate"}, {"i": "EC:2.7.7.43", "l": "\"N-acylneuraminate cytidylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15252", "l": "3,4,5-trihydroxybenzoate + UDP-alpha-D-glucose <=> 1-O-galloyl-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.15"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13646", "l": "beta-D-glucose + NADP(+) => D-glucono-1,5-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682598", "l": "ATM phosphorylates HERC2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61823", "l": "3beta-hydroxy-5alpha-androstan-17-one + UDP-alpha-D-glucose <=> epiandrosterone 3-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863463", "l": "STON2 binds SYT proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450466", "l": "AUF1:mRNA complex is destroyed (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38637", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52305", "l": "H2O + L-ectoine => (2S)-2-acetamido-4-aminobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60770", "l": "3 CO2 + gibberellin A25 + H(+) + H2O + 3 succinate => 3 2-oxoglutarate + gibberellin A12 + 3 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013009", "l": "RHOA binds effectors at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013110", "l": "RHOC binds effectors at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17753", "l": "S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine"}, {"i": "EC:4.4.1.21", "l": "\"S-ribosylhomocysteine lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0034040", "l": "ATPase-coupled lipid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46907", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A hexaacyl 1-(2-aminoethyl diphosphate) <=> a 1,2-diacyl-sn-glycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404142", "l": "atROL binds RBP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20018", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2 => 5,10-methylenetetrahydromethanopterin + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26300", "l": "1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH <=> 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32806", "l": "ATP + H2O + urea(out) <=> ADP + H(+) + phosphate + urea(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9606887", "l": "p-CD19:VAV binds PI3K and GRB2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852019", "l": "MET bound PI3K generates PIP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847968", "l": "PTEN binds FRK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24337", "l": "a carboxylate + ATP + CoA => AMP + an acyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59889", "l": "4-chloro-L-lysine + AH2 + O2 => A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389463", "l": "Proteinase-activated receptors can bind thrombin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37249", "l": "phosphate + thymidine => H2O + thymidine 3'-monophosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-517705", "l": "p-S318,221-HuR binds mRNA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38446", "l": "a long chain fatty alcohol + an acyl-CoA <=> a wax ester + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15122", "l": "dithioerythritol + thiosulfate => cis-1,2-dithiane-4,5-diol + 2 H(+) + hydrogen sulfide + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18971", "l": "a long-chain alkane + CO2 => a long-chain fatty acid + H(+) + hnu"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161775", "l": "ALOX12 oxidises LTA4 to LXA4/B4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019172", "l": "glyoxalase III activity"}, {"i": "MetaCyc:GLYOXIII-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15141", "l": "4-methylphenol + H2O + 4 oxidized [azurin] = 4-hydroxybenzaldehyde + 4 H(+) + 4 reduced [azurin]"}, {"i": "EC:1.17.9.1", "l": "\"4-methylphenol dehydrogenase (hydroxylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9625482", "l": "PTK2 binds activated EGFR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34857", "l": "N-(cyanomethyl)glycine + NH4(+) => 2 H2O + iminodiacetonitrile"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35177", "l": "novobiocin(out) => novobiocin(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59439", "l": "4-amino-L-phenylalanine + ATP + holo-[peptidyl-carrier protein] <=> 4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798749", "l": "Exocytosis of specific granule lumen proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35942", "l": "brevianamide F + dimethylallyl diphosphate <=> diphosphate + tryprostatin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9709098", "l": "DHFR dimer reduces FOLA to DHF (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428750", "l": "Gq activation by TP receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42754", "l": "H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine => pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39345", "l": "(2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H2O => (3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41618", "l": "D-ribose 5-phosphate + phosphate => D-ribose 2,5-bisphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10066", "l": "(6S)-5,6,7,8-tetrahydrofolate + 2-methylserine => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + D-alanine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661161", "l": "USP9X:SNCA dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20874", "l": "(20S)-ginsenoside Rb1 + H(+) + UDP => (20S)-ginsenoside Rd + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016223", "l": "beta-alanine-pyruvate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350158", "l": "LGMN degrades GC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13451", "l": "2-oxoglutarate + H(+) + NADH => 2-hydroxyglutarate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2855047", "l": "Hydrolysis of internal thioester in C4b (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174456", "l": "Joining of adjacent Okazaki fragments of the C-strand (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24526", "l": "5-O-beta-D-mycaminosyltylonolide + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 20-oxo-5-O-beta-D-mycaminosyltylonolide + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12178", "l": "H(+) + N-methylphenylethanolamine + S-adenosyl-L-homocysteine => phenylethanolamine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034849", "l": "2-naphthoate CoA-transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.24"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674529", "l": "AAMP binds to TBXA2R (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878679", "l": "Expression of KLF15 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.24"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15668", "l": "aldehydo-D-glucose + L-lysyl-[protein] <=> H2O + N(6)-(D-fructosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64241", "l": "glycine + octanoyl-CoA => CoA + H(+) + N-octanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61641", "l": "H(+) + isophthalyl-CoA => benzoyl-CoA + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2152276", "l": "Secretion of transmembrane collagens (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050587", "l": "chlorite O2-lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418845", "l": "Activation of caspase-3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59208", "l": "ATP + H(+) + octadecanoate = diphosphate + octadecanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48140", "l": "2 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] = 2 oxidized [2Fe-2S]-[ferredoxin] + red chlorophyll catabolite"}, {"i": "EC:1.14.15.17", "l": "\"Pheophorbide a oxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62749", "l": "H2O + lovastatin => (S)-2-methylbutanoate + H(+) + monacolin J"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689630", "l": "BAP1 binds BAP1-interacting complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60161", "l": "ATP + H2O + vincristine(in) => ADP + H(+) + phosphate + vincristine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16558", "l": "2-amino-3-carboxymuconate 6-semialdehyde + H(+) => 2-aminomuconate 6-semialdehyde + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16384", "l": "L-arabinitol + NAD(+) <=> H(+) + L-xylulose + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49391", "l": "UDP-alpha-D-glucose + validoxylamine A <=> H(+) + UDP + validamycin A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35107", "l": "3-nitrotyramine + H2O + O2 = 4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47813", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-phosphate + NADPH + O2 => 9-ribosyl-trans-zeatin 5'-phosphate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.32", "l": "\"17-alpha-hydroxyprogesterone deacetylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50297", "l": "N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + O2 + reduced [NADPH--hemoprotein reductase] => 2-oxo-N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-265456", "l": "NPC1L1 binds ezetimibe (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61900", "l": "AH2 + betaenone C = A + betaenone B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40113", "l": "butanoate + CoA + H(+) => butanoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004425", "l": "indole-3-glycerol-phosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38089", "l": "1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37619", "l": "(9Z)-octadecenoyl-CoA + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51537", "l": "L-tyrosyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-L-tyrosyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805981", "l": "HMGB1 release from cells (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10789", "l": "2-dehydro-D-gluconate + ATP => 6-phospho-2-dehydro-D-gluconate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35680", "l": "dodecanoyl-CoA + H(+) + L-serine => 3-oxotetradecasphinganine + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38781", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29201", "l": "menaquinol-8 + orotate => (S)-dihydroorotate + menaquinone-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161282", "l": "Elastic fibres bind associated proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34865", "l": "3-hydroxyadipyl-CoA => 2,3-didehydroadipyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627106", "l": "SMAC (DIABLO) forms dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654167", "l": "Activated FGFR1 binds PLCG1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53121", "l": "(3beta,5alpha,17beta)-3-hydroxyandrostan-17-yl sulfate + NADP(+) => 5alpha-dihydrotestosterone sulfate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2167942", "l": "Collagen type XIII ectodomain shedding (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2731141", "l": "Syndecan-1 binds fibronectin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008812", "l": "choline dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033880", "l": "phenylacetyl-CoA hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16805", "l": "2-oxoglutarate + deacetoxycephalosporin C + O2 = CO2 + deacetylcephalosporin C + succinate"}, {"i": "EC:1.14.11.26", "l": "\"Deacetoxycephalosporin-C hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15998", "l": "anthraniloyl-CoA + 2 H(+) + 2 NADH + O2 => 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37157", "l": "1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23433", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] => (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333678", "l": "CPNEs bind PL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102960", "l": "momilactone-A synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50984", "l": "prostaglandin E2(out) = prostaglandin E2(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20242", "l": "nicotinate + S-adenosyl-L-methionine => N-methylnicotinate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63895", "l": "ATP + H2O + L-tryptophan <=> AMP + D-tryptophan + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11252", "l": "H(+) + hydroxylamine + L-asparagine = beta-L-aspartylhydroxamate + NH4(+)"}, {"i": "EC:2.3.2.7", "l": "\"Aspartyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12833", "l": "an N-acyl-D-glutamate + H2O = a carboxylate + D-glutamate"}, {"i": "EC:3.5.1.82", "l": "\"N-acyl-D-glutamate deacylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47160", "l": "4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) = 4-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050402", "l": "xylono-1,4-lactonase activity"}, {"i": "MetaCyc:XYLONO-14-LACTONASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139842", "l": "Binding of Syk tyrosine kinase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621571", "l": "CD209 binds ICAM2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.9", "l": "\"Glyceraldehyde-3-phosphate dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-178208", "l": "SMAD7 binds to SMURF2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051669", "l": "fructan beta-fructosidase activity"}, {"i": "MetaCyc:3.2.1.80-RXN"}, {"i": "EC:3.2.1.80", "l": "\"Fructan beta-fructosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58290", "l": "25-substituted-cholesteryl beta-D-glucoside + N-octanoylsphing-4-enine => 25-substituted-cholesterol + beta-D-glucosyl-N-octanoylsphing-4E-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052860", "l": "2'-deoxymugineic-acid 3-dioxygenase activity"}, {"i": "KEGG.REACTION:R07187"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0052712", "l": "inositol phosphosphingolipid phospholipase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10027", "l": "L-lysyl-[histone] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322434", "l": "XIAP dissociates from ub-TLE (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13244", "l": "ATP + L-fucose <=> ADP + beta-L-fucose 1-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47089", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) => 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32389", "l": "dihydrocarvone + H(+) + NADH => dihydrocarveol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47694", "l": "5'-deoxyadenosine + A + H(+) + L-methionine + neomycin B => AH2 + neomycin C + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9679775", "l": "COMT binds COMT Inhibitors (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23985", "l": "cholesterol + NADP(+) => cholesta-5,7-dien-3beta-ol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40105", "l": "CoA + H(+) + propanoate => H2O + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10761", "l": "citrate => acetate + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12090", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP => an N-acylsphing-4-enine + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62344", "l": "6-hydroxydeoxybrevianamide E + dimethylallyl diphosphate = diphosphate + notoamide S"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685319", "l": "CX3 complex formation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134914", "l": "Beta-catenin migrates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47641", "l": "adenosine(1785)/adenosine(1786) in 18S rRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(6)-dimethyladenosine(1785)/N(6)-dimethyladenosine(1786) in 18S rRNA + 4 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015593", "l": "allose transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52199", "l": "(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-aci-nitro-2-(phenyl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852552", "l": "MST1R autophosphorylates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25348", "l": "D-tyrosyl-tRNA(Tyr) + H2O => D-tyrosine + tRNA(Tyr)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047286", "l": "NAD+-diphthamide ADP-ribosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050389", "l": "uronolactonase activity"}, {"i": "RHEA:13337", "l": "D-glucurono-6,2-lactone + H2O = D-glucuronate + H(+)"}, {"i": "EC:3.1.1.19", "l": "\"Uronolactonase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22570", "l": "ascopyrone P => ascopyrone M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63481", "l": "NADP(+) + prostaglandin F2alpha => 15-oxoprostaglandin F2alpha + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004758", "l": "serine C-palmitoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-517674", "l": "p-S158,221-HuR binds mRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13682", "l": "a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine => a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39944", "l": "a 1-acylglycerol + an acyl-CoA => a 1,2-diacylglycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45737", "l": "(3E)-hexenoyl-CoA => (2E)-hexenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10432", "l": "2-(acetamidomethylene)succinate + H(+) + 2 H2O = acetate + CO2 + NH4(+) + succinate semialdehyde"}, {"i": "EC:3.5.1.29", "l": "\"2-(acetamidomethylene)succinate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.34"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199112", "l": "CRTAM binds to NECL2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49028", "l": "(-)-bursehernin + O2 + reduced [NADPH--hemoprotein reductase] = (-)-5'-demethylyatein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.131", "l": "\"Bursehernin 5'-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40372", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ATP => 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17675", "l": "3',4',5,7-tetrahydroxy-3-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => quercetin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13557", "l": "ATP + glycine + L-gamma-glutamyl-L-cysteine = ADP + glutathione + H(+) + phosphate"}, {"i": "EC:6.3.2.3", "l": "\"Glutathione synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635861", "l": "NUMB:ITCH binds GLI1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052606", "l": "chlorophyllide a oxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2317387", "l": "PTEN cancer mutants do not dephosphorylate PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47789", "l": "a cytidine in 28S rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12013", "l": "ATP + thiamine => ADP + H(+) + thiamine phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187264", "l": "Platelet glycoprotein IV (CD36) binds ligands (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021596", "l": "Membrane estrogen receptors bind SRC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2465940", "l": "atRAL is reduced to atROL (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382053", "l": "Translocation of PDGF from ER to Golgi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19341", "l": "2 H(+) + O2 + octane + 2 reduced [rubredoxin] = H2O + octan-1-ol + 2 oxidized [rubredoxin]"}, {"i": "EC:1.14.15.3", "l": "\"Alkane 1-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1297444", "l": "Binding of cAMP to HCN channels (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373087", "l": "Receptor CCR6 binds CCL20 ligand (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665706", "l": "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20497", "l": "2-arylethylamine + acetyl-CoA = CoA + H(+) + N-acetyl-2-arylethylamine"}, {"i": "RHEA:25217", "l": "acetyl-CoA + serotonin = CoA + H(+) + N-acetylserotonin"}, {"i": "EC:2.3.1.87", "l": "\"Aralkylamine N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000287", "l": "magnesium ion binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052678", "l": "levopimaradiene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55863", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29619", "l": "alpha-maltotetraose + beta-maltose = alpha-maltopentaose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40173", "l": "(2E)-dodecenoyl-CoA + H2O2 => dodecanoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670431", "l": "Phosphorylated KIT mutants bind PI3K (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021068", "l": "PalmS-ESRs bind CAVs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1964496", "l": "STING binds TRIM32 or TRIM56  (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.204"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14060", "l": "a 1,2-diacyl-sn-glycerol + a glycerophospholipid <=> a monoacylglycerophospholipid + a triacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032548", "l": "pyrimidine deoxyribonucleoside binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39262", "l": "(3R)-hydroxy-(13Z)-docosenoyl-CoA <=> (2E,13Z)-docosadienoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65948", "l": "a 2'-deoxyadenosine in DNA + acetyl-CoA + AH2 + NH4(+) + O2 = A + a N(6)-methylcarbamoyl-2'-deoxyadenosine in DNA + CoA + H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604752", "l": "Initial activation of proMMP13 by MMP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655244", "l": "Activated FGFR3 mutants bind PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875443", "l": "USP8 deubiquitinates LRIG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39049", "l": "2 H(+) + H2O + hexacosanedioate + oxidized [NADPH--hemoprotein reductase] => 26-oxohexacosanoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35437", "l": "cyanidin 3-O-[beta-D-xylosyl-(1->2)-beta-D-galactoside] + H(+) + UDP => cyanidin 3-O-beta-D-galactoside + UDP-alpha-D-xylose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626039", "l": "pGFAP binds GFAP in LAMP2a multimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34199", "l": "2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 = bracteatin 6-O-beta-glucoside + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610760", "l": "GLI1 is degraded by the proteasome after ubiquitination by ITCH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437995", "l": "Activated JNK migrates to the nucleoplasm (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65328", "l": "A + chrodrimanin F = AH2 + chrodrimanin H"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949580", "l": "F1Fo ATP synthase dimerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43526", "l": "aminoacetone + CO2 + NADPH => L-allo-threonine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.21"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878056", "l": "RUNX1:CBFB binds EP300 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56022", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48423", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) <=> CMP + ganglioside GM1 (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791172", "l": "Expression of WIPI1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983150", "l": "Proteasomal cleavage of substrate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11708", "l": "H2O + IMP + NAD(+) = H(+) + NADH + XMP"}, {"i": "EC:1.1.1.205", "l": "\"IMP dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.66", "l": "\"XTP/dITP diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810392", "l": "TMEM55B translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63269", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + O2 => 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222020", "l": "NUAK1 phosphorylates TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.98.-", "l": "\"With other known acceptors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17946", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] => (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1614591", "l": "Excess cysteine yields lanthionine and H2S (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41857", "l": "3-oxodecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxydecanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26060", "l": "[Co(I) methylamine-specific corrinoid protein] + H(+) + methylamine => [methyl-Co(III) methylamine-specific corrinoid protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28876", "l": "H(+)(in) + L-tyrosine(in) => H(+)(out) + L-tyrosine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10843", "l": "H2O + O-phospho-L-homoserine <=> L-threonine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862771", "l": "PLA2G2A binds bacterial phospholipids (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33409", "l": "diphosphate + glycyl-5'-AMP => ATP + glycine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.47"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43808", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669870", "l": "Regorafenib-resistant KIT mutants do not bind regorafenib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804253", "l": "MDM2 ubiquitinates JMY (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57708", "l": "(E)-coniferaldehyde + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-4-trans-coniferyl aldehyde + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47644", "l": "adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-167419", "l": "The receptor:G-protein complex releases GDP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627089", "l": "CASP9 is phosphorylated at T125 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033723", "l": "fluoroacetaldehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0016843", "l": "amine-lyase activity"}, {"i": "EC:4.3.3.-", "l": "\"Amine-lyases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22985", "l": "carbamoyl phosphate + oxamate => N-carbamoyl-2-oxoglycine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47592", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) = CMP + ganglioside GP1c (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60566", "l": "2-deoxy-D-glucose 6-phosphate + ADP + H(+) => 2-deoxy-D-glucose + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694527", "l": "Loss of SAR1B GTPase (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54366", "l": "acetoin => 2 acetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877902", "l": "Activated AR binds RUNX2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36608", "l": "2-oxoglutarate + L-arginine + O2 => (2S,3S)-hydroxyarginine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013108", "l": "GDIs block activation of RHOC (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985943", "l": "p-Y701-STAT1 dimerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102164", "l": "2-heptyl-3-hydroxy-4(1H)-quinolone synthase activity"}, {"i": "RHEA:37871", "l": "2-heptyl-4(1H)-quinolone + H(+) + NADH + O2 = 2-heptyl-3-hydroxy-4(1H)-quinolone + H2O + NAD(+)"}, {"i": "EC:1.14.13.182", "l": "\"2-heptyl-3-hydroxy-4(1H)-quinolone synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "78.423603998002051", "identifiers": [{"i": "GO:0016863", "l": "intramolecular oxidoreductase activity, transposing C=C bonds"}, {"i": "EC:5.3.3.-", "l": "\"Transposing C=C bonds\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001080", "l": "chitosan binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11511", "l": "2-oxoglutarate + L-aspartyl-[protein] + O2 <=> 3-hydroxy-L-aspartyl-[protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65840", "l": "ATP(out) + Mg(2+)(out) + phosphate(in) = ATP(in) + Mg(2+)(in) + phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22545", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O => a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004876", "l": "complement component C3a receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38064", "l": "2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA => 1-dodecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.24"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.43", "l": "\"(S)-dichlorprop dioxygenase (2-oxoglutarate)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167683", "l": "TrkA phosphorylates PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20734", "l": "[protein]-disulfide + [thioredoxin]-dithiol => [protein]-dithiol + [thioredoxin]-disulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19380", "l": "NADP(+) + reduced riboflavin <=> 2 H(+) + NADPH + riboflavin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1461995", "l": "pro-defensin alpha 5 is stored in Paneth cell granules (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34823", "l": "(E)-feruloyl-CoA + (E)-feruloylacetyl-CoA + H2O = CO2 + 2 CoA + curcumin"}, {"i": "EC:2.3.1.217", "l": "\"Curcumin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43284", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23713", "l": "NADP(+) + pregnan-21-ol => H(+) + NADPH + pregnan-21-al"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805785", "l": "AKT phosphorylates PHF20 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35629", "l": "delphinidin 3,3',5-tri-O-beta-D-glucoside + H(+) + UDP => delphinidin 3,5-bis-O-beta-D-glucoside + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914022", "l": "SHP2 can recruit GRB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693609", "l": "ATM phosphorylates TP53 at S15 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57550", "l": "[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-beta-macrocarpene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010211", "l": "IAA-Leu conjugate hydrolase activity"}, {"i": "MetaCyc:RXN-2982"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656214", "l": "MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57133", "l": "L-ascorbate + O2 + tyramine => (2R)-1-(4-hydroxyphenyl)-2-aminoethanol + H2O + L-dehydroascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48027", "l": "1,2,3-tripropanoylglycerol + H2O <=> dipropanoylglycerol + H(+) + propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426164", "l": "SREBP1A,2 binds the SC5DL promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45774", "l": "[(1->4)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate => [(1->4)-beta-D-mannosyl](n) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23735", "l": "(R)-5-diphosphomevalonate + ATP <=> ADP + CO2 + isopentenyl diphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66075", "l": "4-methyl-2-oxopentanoate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210426", "l": "Glutamate synaptic vesicle docking and priming (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202604", "l": "Formation of a heteromeric BMP receptor complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47223", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta,16alpha-dihydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19092", "l": "S-adenosyl-L-methionine + uroporphyrinogen III <=> H(+) + precorrin-1 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36801", "l": "a ribonucleoside 5'-phosphate + H(+) + phosphate => a ribonucleoside 5'-diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36945", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045130", "l": "keratan sulfotransferase activity"}, {"i": "MetaCyc:KERATAN-SULFOTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-182988", "l": "Sprouty lures CBL away from EGFR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11225", "l": "ATP + 2 D-alanine => ADP + D-alanyl-D-alanine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209910", "l": "Iodide is taken up by thyroid epithelial cells (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62153", "l": "dGMP + dTTP => dGDP + dTDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102810", "l": "glutarate-semialdehyde dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60812", "l": "2-oxoglutarate + gibberellin A12 aldehyde + O2 = CO2 + gibberellin A12 + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37429", "l": "a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28090", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP"}, {"i": "EC:2.7.8.33", "l": "\"UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247922", "l": "GGCT transforms gGluCys to OPRO (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428917", "l": "G13 activation by TP receptor (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16914", "l": "a CDP-1,2-diacyl-sn-glycerol + L-serine => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446870", "l": "Polyubiquitinated TRAF6 binds the TAK1 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446089", "l": "BP180 interacts extracellularly with Laminin 332 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56253", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-seryl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33066", "l": "H(+) + NAD(+) + 2 reduced [2Fe-2S]-[putidaredoxin] <=> NADH + 2 oxidized [2Fe-2S]-[putidaredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30161", "l": "germacra-1(10),4,11(13)-trien-12-al + H(+) + NADPH => germacra-1(10),4,11(13)-trien-12-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605057", "l": "ABCA1 gene transcription regulated by NR1H2 or NR1H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61986", "l": "NAD(+) + ubiquinol-10 => H(+) + NADH + ubiquinone-10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801762", "l": "REG3A oligomerize to form a pore complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.155", "l": "\"Xyloglucan-specific endo-processive beta-1,4-glucanase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53193", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O => 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52662", "l": "AMP + an L-alpha-aminoacyl-[ACP] + diphosphate => an L-alpha-amino acid + ATP + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052808", "l": "reduced coenzyme F420:NADP+ oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5631941", "l": "SESN1,2,3 bind AMPK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35581", "l": "cyanidin 3-O-[6-O-(4-O-beta-D-glucosyl-p-coumaroyl)-2-O-(2-O-sinapoyl-beta-D-xylosyl)-beta-D-glucosyl]-5-O-(6-O-malonyl-beta-D-glucoside) + D-glucose => 1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-[6-O-(4-O-beta-D-glucosyl-p-coumaroyl)-2-O-(beta-D-xylosyl)-beta-D-glucosyl]-5-O-(6-O-malonyl-beta-D-glucoside)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047300", "l": "pyridoxamine-pyruvate transaminase activity"}, {"i": "KEGG.REACTION:R01712"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.116"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20568", "l": "(2E)-geranyl diphosphate + H2O <=> (1S,2S,4R)-endo-fenchol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-188002", "l": "Rab5-mediated recruitment of class III PI3K to TLR9 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59829", "l": "H2O + S-inosyl-L-homocysteine => inosine + L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791109", "l": "GADD45A binds PCNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37813", "l": "1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55173", "l": "2-oxoglutarate + hexanoyl-CoA + O2 => 2-hydroxyhexanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28131", "l": "baicalin + H2O => baicalein + D-glucuronate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1253321", "l": "GFAP gene expression is inhibited by ERBB4:TAB2:NCOR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687384", "l": "SARS-CoV-1 gRNA complement (minus strand):RTC binds RTC inhibitors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693061", "l": "STAMBP binds STAM (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983427", "l": "Expression of peptide bound class I MHC on cell surface (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867041", "l": "EGFR phosphorylates EPS15 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49329", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spheroidene => 2-hydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171141", "l": "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20249", "l": "L-alanine = D-alanine"}, {"i": "EC:5.1.1.1", "l": "\"Alanine racemase\""}]}
{"type": "biolink:MolecularActivity", "ic": "61.174745187870577", "identifiers": [{"i": "GO:0140657", "l": "ATP-dependent activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047426", "l": "ricinine nitrilase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209960", "l": "Diiodinated tyrosine can be deiodinated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "71.045893708194711", "identifiers": [{"i": "GO:1990837", "l": "sequence-specific double-stranded DNA binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034955", "l": "2,3-dihydroxydiphenyl ether dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215152", "l": "TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8871266", "l": "YAP1 binds TEAD3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16216", "l": "3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9690449", "l": "S1PR1 bind S1P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41711", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphoethanolamine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28065", "l": "alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043806", "l": "keto acid formate lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615910", "l": "SUMOylation of PCNA with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41266", "l": "NAD(+) + prostaglandin A1 <=> 15-keto-prostaglandin A1 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37053", "l": "ATP + chlorophyllide a + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin] => 3-deacetyl-3-vinylbacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950766", "l": "IL27RA dimerizes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141439", "l": "Release of activated MAD2 from kinetochores (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31724", "l": "liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] => (2R,3S)-2,4',7-trihydroxyisoflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29468", "l": "H(+)(out) + K(+)(in) => H(+)(in) + K(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975097", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53089", "l": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine => 2-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003945", "l": "N-acetyllactosamine synthase activity"}, {"i": "RHEA:17745", "l": "N-acetyl-D-glucosamine + UDP-alpha-D-galactose = beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP"}, {"i": "EC:2.4.1.90", "l": "\"N-acetyllactosamine synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990827", "l": "deaminase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66084", "l": "L-kynurenine + oxaloacetate = H2O + kynurenate + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019828", "l": "aspartic-type endopeptidase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33593", "l": "CoA + H(+) + N-tetracosanoylsphinganine => sphinganine + tetracosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58693", "l": "FADH2-C4alpha-hydroperoxide + H(+) + NADH + rifamycin SV => FADH2 + H2O + NAD(+) + rifamycin SV hemiaminal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10690", "l": "phosphate + streptomycin => H2O + streptomycin 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32771", "l": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate = 2,6-dioxo-6-phenylhexa-3-enoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25487", "l": "(2E)-geranyl diphosphate <=> (1S,4R)-camphene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17306", "l": "H2O + N(omega),N(omega)-dimethyl-L-arginine => dimethylamine + L-citrulline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851919", "l": "Activated MET binds GAB1 and GRB2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11513", "l": "salicyl alcohol + UDP-alpha-D-glucose => H(+) + salicin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36435", "l": "a 1,2-diacyl-sn-glycero-3-phosphate(in) = a 1,2-diacyl-sn-glycero-3-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390909", "l": "HRH2 binds hist (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52092", "l": "5-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47421", "l": "A + glutaryl-CoA => (2E)-glutaconyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59313", "l": "D-galactose + O2 => D-galactono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1973968", "l": "Beta-defensins 4A and 103 bind CCR2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19376", "l": "H2O + L-saccharopine + NADP(+) <=> 2-oxoglutarate + H(+) + L-lysine + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35671", "l": "(S)-5'-oxoaverantin + H(+) = (1'S,5'S)-averufin + H2O"}, {"i": "EC:4.2.1.142", "l": "\"5'-oxoaverantin cyclase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18580", "l": "3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine <=> 3-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389919", "l": "Grb2 binds pBTLA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46808", "l": "[trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine = [trehalose-6-phosphate synthase]-S-methyl-L-cysteine + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.318", "l": "\"[Trehalose-6-phosphate synthase]-L-cysteine S-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700137", "l": "ALK:MDK dimerization (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59383", "l": "4-amino-4-deoxyprephenate + NAD(+) <=> 3-(4-aminophenyl)pyruvate + CO2 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51573", "l": "(25S)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730884", "l": "Phosphorylation of NTAL by p-SYK/Lyn (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27672", "l": "myo-inositol + phosphate => 1D-myo-inositol 1-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213241", "l": "Formation of nonameric complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977301", "l": "Histidine is decarboxylated to histamine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14295", "l": "D-glucono-1,5-lactone + H(+) + NADH => D-glucose + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-167408", "l": "The high affinity receptor complex binds to G-protein (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103032", "l": "tartronate semialdehyde reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19515", "l": "H(+) + L-citrulline + phosphate => carbamoyl phosphate + L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61050", "l": "H(+) + H2O + horhammericine + oxidized [NADPH--hemoprotein reductase] => lochnericine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250280", "l": "ROS oxidize thioredoxin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2002428", "l": "Removal of fibrillar collagen N-propeptides (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60006", "l": "(L-glutamyl)n-L-gamma-glutamyl-L-glutamyl-[protein] + L-glutamate => (L-glutamyl)n+1-L-gamma-glutamyl-L-glutamyl-[protein] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948136", "l": "ULK1 Translocates to the mitochondria (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12662", "l": "(R)-carnitine + hexadecanoyl-CoA => CoA + O-hexadecanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0015288", "l": "porin activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26299", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O => 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0051019", "l": "mitogen-activated protein kinase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65176", "l": "A + protoaustinoid A = AH2 + protoaustinoid B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.9", "l": "\"[Goodpasture-antigen-binding protein] kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63598", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678981", "l": "TLR9 processing at neutral pH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11916", "l": "13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32002", "l": "(2E,6E)-farnesyl diphosphate <=> bicyclogermacrene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9006850", "l": "IL21 receptor JAK phosphorylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.43", "l": "\"Cathepsin V\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983700", "l": "SYK binds the activated BCR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18826", "l": "[(1->6)-alpha-D-glucosyl](n) + sucrose => [(1->6)-alpha-D-glucosyl](n+1) + D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202168", "l": "Phosphorylation of ZAP-70 by Lck (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12296", "l": "deacetylipecoside + H2O = dopamine + secologanin"}, {"i": "EC:4.3.3.4", "l": "\"Deacetylipecoside synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20594", "l": "H2O + N-acetyl-D-glucosamine => acetate + D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32609", "l": "(6E)-8-hydroxygeranial + H(+) + NADPH => (6E)-8-hydroxygeraniol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433415", "l": "Activation of RAC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27877", "l": "isochorismate <=> pyruvate + salicylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13583", "l": "H(+) + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP => N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809309", "l": "MTMR6 binds MTMR9 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004354", "l": "glutamate dehydrogenase (NADP+) activity"}, {"i": "MetaCyc:GLUTDEHYD-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17977", "l": "a long-chain primary fatty alcohol + H2O + 2 NAD(+) = a long-chain fatty acid + 3 H(+) + 2 NADH"}, {"i": "EC:1.1.1.192", "l": "\"Long-chain-alcohol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110239", "l": "MPG glycosylase mediated recognition and binding of ethenoadenine  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62603", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> 5-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64725", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (7S,14S)-dihydroperoxy-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018738", "l": "S-formylglutathione hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031804", "l": "type 7 metabotropic glutamate receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56030", "l": "3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) => 3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635842", "l": "ULK3 phosphorylates GLI (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18567", "l": "9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine => 19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-888577", "l": "Synthesis of GABA by GAD2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090439", "l": "tetraketide alpha-pyrone synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5662986", "l": "MT2A binds copper (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27876", "l": "pyruvate + salicylate => isochorismate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44953", "l": "(2E)-octenoyl-CoA + H(+) + NADPH => NADP(+) + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55177", "l": "2-oxoglutarate + butanoyl-CoA + O2 => 2-hydroxybutanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3159227", "l": "HIV Virion Budding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62415", "l": "(E)-feruloyl-CoA + H2O <=> acetyl-CoA + vanillin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31156", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) => (4S)-4-hydroxy-L-glutamate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52598", "l": "3-oxocholan-24-oyl-CoA + H(+) + NADH => lithocholoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166015", "l": "Association of LBP with LPS (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47132", "l": "11-cis-retinal + H2O + NAD(+) = 11-cis-retinoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47358", "l": "an aliphatic alcohol + H(+) + octanoate => an octanoate ester + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668904", "l": "Formation of the CTF18 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53269", "l": "L-ribulose => L-xylulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62858", "l": "GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12050", "l": "3-oxoadipyl-CoA + succinate => 3-oxoadipate + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050551", "l": "myrcene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679029", "l": "C-ter TLR7 dimer binds HCQ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174070", "l": "Association of Cdh1 with the APC/C (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53033", "l": "2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate => 17beta-estradiol 2-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35817", "l": "4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate => 4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39997", "l": "a fatty acid + ethanolamine => an N-acylethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102212", "l": "unsaturated chondroitin disaccharide hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41309", "l": "(9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.4", "l": "\"Thymidine phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-744231", "l": "SLC35D2 exchanges UDP-sugars for UMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.59", "l": "\"5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24414", "l": "4-formylbenzenesulfonate + H(+) + NADH => 4-(hydroxymethyl)benzenesulfonate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0015453", "l": "oxidoreduction-driven active transmembrane transporter activity"}, {"i": "TCDB:3.D"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210886", "l": "NEUROG3-dependent synthesis of PAX4 protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28756", "l": "a ubiquinone + sn-glycerol 3-phosphate => a ubiquinol + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64866", "l": "CO2 + IDP + phosphoenolpyruvate => ITP + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25063", "l": "3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) => 3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140486", "l": "zinc ion sequestering activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419351", "l": "PAF receptor binds platelet activating factor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983707", "l": "SYK autophosphorylates at the activated BCR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30869", "l": "(indol-3-yl)acetate + 2 H(+) + NADH => H2O + indole-3-acetaldehyde + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27564", "l": "(2E)-geranyl diphosphate + 7 isopentenyl diphosphate => all-trans-nonaprenyl diphosphate + 7 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5622129", "l": "FABP5 binds atRA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693608", "l": "Initial resection of double-strand break ends (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34614", "l": "N-acyl-15-methylhexadecasphing-4-enine + UDP-alpha-D-glucose <=> H(+) + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655837", "l": "Expression of Glycerol-3-phosphate Acyltransferase (GPAM, GPAT) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50651", "l": "2-(2-methylsulfanyl)ethylmalate <=> 2-(2-methylsulfanyl)ethylmaleate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102621", "l": "emindole-SB NADPH:oxygen oxidoreductase (14,15-epoxidizing) activity"}, {"i": "MetaCyc:RXN-15496"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033837", "l": "anthocyanin 3'-O-beta-glucosyltransferase activity"}, {"i": "RHEA:35627", "l": "delphinidin 3,5-bis-O-beta-D-glucoside + UDP-alpha-D-glucose = delphinidin 3,3',5-tri-O-beta-D-glucoside + H(+) + UDP"}, {"i": "EC:2.4.1.238", "l": "\"Delphinidin 3,5-di-O-glucoside 3'-O-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49896", "l": "(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate = 5,10-dihydrophenazine-1,6-dicarboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389026", "l": "Galanin receptors can bind galanin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210289", "l": "Recruitment of SYK to p-DAP12 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804229", "l": "JMY, TTC5 and EP300 bind (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357445", "l": "PAK1-3 dimer disassociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222738", "l": "Carboxymycobactin gets secreted (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61946", "l": "24-methylene cholesteryl beta-D-glucoside + H(+) + UDP => 24-methylenecholesterol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204773", "l": "Interaction of Tie2 and Grb7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13921", "l": "ent-kaur-16-en-19-oate + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = gibberellin A12 aldehyde + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15779", "l": "1-guanidino-1-deoxy-scyllo-inositol + phosphate => 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39773", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20481", "l": "3'-phosphoadenylyl sulfate + coelenterazine h = adenosine 3',5'-bisphosphate + H(+) + luciferyl sulfate"}, {"i": "EC:2.8.2.10", "l": "\"Renilla-luciferin sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30086", "l": "4 Cu(+) + 4 H(+) + O2 <=> 4 Cu(2+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159194", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56651", "l": "3-oxochol-4-en-24-oyl-CoA + NAD(+) <=> 3-oxochol-4,6-dien-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46566", "l": "acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+) => acetyl-CoA + apo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33029", "l": "3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + spheroiden-2-one => 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spheroidene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022396", "l": "MME:Zn2+ hydrolyses AGT(34-43) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250947", "l": "B-WICH complex binds rDNA promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20491", "l": "1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52157", "l": "(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] => (R)-mandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019974", "l": "interleukin-14 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5631885", "l": "PRDX1 overoxidizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211960", "l": "CYP2U1 19-hydroxylates ARA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64828", "l": "3-hydroxybenzyl alcohol + acetyl-CoA = 3-hydroxy-benzyl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60558", "l": "pseudouridine(35) in tRNA(Tyr) => uridine(35) in tRNA(Tyr)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857305", "l": "Activated CEBPB and NFKB complex bind IL6 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60580", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0047023", "l": "androsterone dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299484", "l": "TIMM8:TIMM13 chaperones hydrophobic proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23759", "l": "D-arabinono-1,4-lactone + O2 <=> dehydro-D-arabinono-1,4-lactone + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37024", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 => (6Z)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35025", "l": "hydroquinone O-beta-D-glucopyranoside(in) => hydroquinone O-beta-D-glucopyranoside(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57457", "l": "E-sinapate + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-trans-sinapate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58822", "l": "acetate + CO2 + Na(+)(out) => H(+) + malonate + Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5631885", "l": "PRDX1 overoxidizes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13347", "l": "diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein] => (2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867344", "l": "OMA1 hydrolyses OPA1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016711", "l": "flavonoid 3'-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29863", "l": "AMP + GTP = ADP + GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20212", "l": "ATP + xylitol <=> ADP + H(+) + xylitol 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46165", "l": "a quinone + H(+) + NADPH => a quinol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23823", "l": "GDP-alpha-D-mannose <=> GDP-4-dehydro-alpha-D-rhamnose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20762", "l": "(6E)-8-hydroxylinalool + A + H2O => AH2 + linalool + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25918", "l": "6-hydroxyquinolin-2(1H)-one + AH2 => A + H2O + quinolin-6-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798139", "l": "TP53 stimulates CASP10 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "81.790986234327661", "identifiers": [{"i": "GO:0016901", "l": "oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor"}, {"i": "EC:1.1.5.-", "l": "\"With a quinone or similar compound as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9006873", "l": "IL21 receptor STAT binding (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322422", "l": "Beta-catenin recruits SMARCA4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201611", "l": "Caspase-mediated cleavage of Rock-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23395", "l": "(nucleoside 5'-monophosphate)n + (n-1) H2O <=> n a ribonucleoside 5'-phosphate + n H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35258", "l": "ATP + H2O + lipid A-core(in) <=> ADP + H(+) + lipid A-core(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36926", "l": "(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20488", "l": "(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-cheilanthifoline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28378", "l": "ATP + N(6)-(D-fructosyl)-L-lysine = ADP + H(+) + N(6)-(6-phospho-D-fructosyl)-L-lysine"}, {"i": "EC:2.7.1.218", "l": "\"Fructoselysine 6-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66218", "l": "asc-DeltaC7-CoA + H2O2 => asc-C7-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23918", "l": "CO2 + UDP-alpha-D-xylose => H(+) + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30794", "l": "dGTP + pyruvate <=> dGDP + H(+) + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41651", "l": "aniline + ATP + L-glutamate <=> ADP + N(5)-phenyl-L-glutamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9634834", "l": "ACHEIs bind ACHE (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49014", "l": "aurachin C epoxide + H2O + NAD(+) => aurachin C + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-982775", "l": "Growth hormone receptor dimerizes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42724", "l": "guanosine(2922) in 27S pre-rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(2922) in 27S pre-rRNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.167", "l": "\"27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29921", "l": "ADP + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609921", "l": "SGTA binds Tail-anchored protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2176452", "l": "Degradation of ubiquitinated SMAD2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68637", "l": "CDC6 protein is synthesized under the control of E2F transcription factors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54508", "l": "all-trans-heptaprenyl diphosphate = beta-heptaprene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13280", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate <=> [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849463", "l": "PTK6 phosphorylates SFPQ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58582", "l": "acetate + catharanthine + H(+) => dihydroprecondylocarpine acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49591", "l": "L-erythrulose 1-phosphate <=> D-erythrulose 4-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20067", "l": "3-epihydroxy-2'-deoxymugineate + CO2 + H(+) + succinate => 2'-deoxymugineate + 2-oxoglutarate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427337", "l": "MBD2 binds methylcytosine in chromatin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043729", "l": "2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786050", "l": "IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62481", "l": "1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O => 2-glutaroyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44560", "l": "4-hydroxybenzoate + all-trans-heptaprenyl diphosphate = 4-hydroxy-3-all-trans-heptaprenylbenzoate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216051", "l": "Integrin alpha6beta1, alpha7beta1, alpha1beta1, alpha2beta1 bind laminin-111 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015462", "l": "ABC-type protein transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41776", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)/18:0) = CMP + ganglioside GM2 (d18:1(4E)/18:0) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42742", "l": "H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016756", "l": "glutathione gamma-glutamylcysteinyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814674", "l": "Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023840", "l": "HATs and coactivators are recruited to the CTSD gene (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35040", "l": "spermidine(in) => spermidine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18720", "l": "3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine <=> 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564117", "l": "Collagen type XIV degradation by MMP9,13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63348", "l": "ATP + L-amino acyl-L-cysteinyl-[protein] = (1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373727", "l": "Nephrin binds CD2AP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63337", "l": "alpha-D-xylose => beta-D-xylose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099077", "l": "histone-dependent DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25243", "l": "(S)-ureidoglycolate + NH4(+) => (S)-2-ureidoglycine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28149", "l": "geranylhydroquinone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3''-hydroxygeranylhydroquinone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28197", "l": "(S)-3-sulfolactate + NAD(+) <=> 3-sulfopyruvate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24578", "l": "H(+) + 2 phosphate => diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12744", "l": "ADP + H(+) + H2O <=> IDP + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32217", "l": "(6S)-NADHX => (6R)-NADHX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60956", "l": "17-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose = (9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637808", "l": "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35288", "l": "chloramphenicol(in) => chloramphenicol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1471314", "l": "HNP1-3 bind CD4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070042", "l": "rRNA (uridine-N3-)-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106323", "l": "(S)-limonene 1,2-monooxygenase NADPH activity"}, {"i": "RHEA:26085", "l": "(4S)-limonene + H(+) + NADPH + O2 = H2O + limonene 1,2-epoxide + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646685", "l": "Aggresome dissociates from dynein and microtubule (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2213017", "l": "Auto-ubiquitination of TRAF3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65795", "l": "fluometuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-[3-(trifluoromethyl)phenyl]-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3262512", "l": "G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665998", "l": "MKL1 binds SRF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11130", "l": "2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA => 4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43328", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44955", "l": "(2E)-octenoyl-CoA + H(+) + NADPH <=> NADP(+) + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54019", "l": "(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48075", "l": "ganglioside GM1 (d18:1(4E)) + H2O <=> ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870465", "l": "RGGT binds the RAB-binding subunit (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38456", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41858", "l": "(3R)-hydroxydecanoyl-[ACP] + NADP(+) => 3-oxodecanoyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30445", "l": "2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly) => 2 glycyl-tRNA(Gly) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22907", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> gibberellin A12 aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49911", "l": "(R)-carnitine(out) + O-acetyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-acetyl-(R)-carnitine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44967", "l": "(2E)-dodecenoyl-CoA + H(+) + NADPH <=> dodecanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62019", "l": "L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose <=> 3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38849", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008863", "l": "formate dehydrogenase (NAD+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65053", "l": "4-(trifluoromethyl)benzyl alcohol + NAD(+) => 4-(trifluoromethyl)benzaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102482", "l": "5-deoxy-D-glucuronate isomerase activity"}, {"i": "RHEA:25840", "l": "5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate"}, {"i": "EC:5.3.1.30", "l": "\"5-deoxy-glucuronate isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265973", "l": "Monoubiquitination of FANCI (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044583", "l": "cellotriose binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18504", "l": "ergosterol + NADP(+) <=> ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0000064", "l": "L-ornithine transmembrane transporter activity"}, {"i": "REACT:R-HSA-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033893", "l": "ribonuclease IV activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45744", "l": "(6S)-5,6,7,8-tetrahydropteroate + NAD(+) = 7,8-dihydropteroate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983138", "l": "Transport of MHC heterotrimer to ER exit site (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60276", "l": "L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.355", "l": "\"[Histone H3]-lysine(9) N-trimethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187698", "l": "RIT/RIN-GTP binds B-RAF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788611", "l": "HYKK phosphorylates 5HLYS (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809707", "l": "MTMR12 binds MTMR2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57320", "l": "acetyl-CoA + N-terminal L-(Asp/Glu)3-[protein] = CoA + H(+) + N-terminal N-acetyl-L-(Asp/Glu)3-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23894", "l": "3-nitroacrylate + H(+) + NADPH => 3-nitropropanoate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730863", "l": "Phosphorylation of CARMA1 by PKC-theta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42118", "l": "17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH => 5alpha-androstane-3alpha,17beta-diol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-561072", "l": "OCT3 mediates renal uptake of organic cations (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373738", "l": "Neurofascin interacts with syntenin-1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.37"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66622", "l": "(25S)-Delta7-dafachronate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 5alpha-cholest-7-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57035", "l": "(E)-2-((N-methylformamido) methylene)succinate + H(+) + 2 H2O <=> CO2 + formate + methylamine + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-481044", "l": "Surface deployment of platelet alpha granule membrane components (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433725", "l": "Interaction of Afadin with F-actin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56972", "l": "(R)-3-hydroxy-2-methylpropanoate + NAD(+) = (R)-methylmalonate semialdehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030156", "l": "benzodiazepine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35440", "l": "CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine => archaetidylserine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38543", "l": "H(+) + malonyl-CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein] = (2-aminobenzoyl)acetyl-CoA + CO2 + L-cysteinyl-[PqsD protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34264", "l": "dimethylallyl diphosphate + fumigaclavine A => diphosphate + fumigaclavine C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31384", "l": "(S)-2,3-epoxysqualene => lupeol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66598", "l": "2 dopamine => O2 + 2 tyramine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37542", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205118", "l": "TRAF6 polyubiquitinates NRIF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12664", "l": "(R)-carnitine + hexadecanoyl-CoA <=> CoA + O-hexadecanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873917", "l": "Translocation of STAT1 dimer to nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684887", "l": "Activation of CHEK1 at resected DNA DSBs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24186", "l": "3,4-dihydroxybenzoate + CO2 => 4,5-dihydroxyphthalate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30486", "l": "N-hydroxy-L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696457", "l": "BDH2 dehydrogenates 3HBA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42372", "l": "16-methoxytabersonine + H2O = (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004317", "l": "3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51077", "l": "2-hydroxy-17beta-estradiol + 3'-phosphoadenylyl sulfate => 2-hydroxy-17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036290", "l": "Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to heparan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21515", "l": "3,6-anhydro-L-galactonate <=> 2-dehydro-3-deoxy-L-galactonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.258", "l": "\"N-terminal methionine N(alpha)-acetyltransferase NatE\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32860", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40505", "l": "N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine => N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12760", "l": "dihydrozeatin + NADP(+) <=> H(+) + NADPH + zeatin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41382", "l": "4-methylphenol + H2O + NAD(+) => H(+) + NADH + O2 + toluene"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042020", "l": "interleukin-23 receptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102179", "l": "24-ethylidenelophenol 4alpha-methyl oxidase activity"}, {"i": "RHEA:59032", "l": "(Z)-24-ethylidenelophenol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}, {"i": "MetaCyc:RXN-11935"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433711", "l": "Cis-homodimerization of nectins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050532", "l": "2-phosphosulfolactate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35902", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA <=> 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18588", "l": "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433415", "l": "Activation of RAC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41161", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H(+) => 1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985104", "l": "OAS2 produces oligoadenylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019911", "l": "structural constituent of myelin sheath"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9625482", "l": "PTK2 binds activated EGFR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785213", "l": "LIPC dimer binds heparin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950757", "l": "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417820", "l": "P2Y9 receptor can bind to LPA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952419", "l": "SMURFs ubiquitinate RUNX3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47483", "l": "deoxycholate + NADP(+) <=> 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205289", "l": "Autophosphorylation of KIT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25773", "l": "2-oxoglutarate + L-asparagine + O2 => (2S,3S)-3-hydroxyasparagine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2106614", "l": "Duplex miRNA is loaded into Argonaute (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018682", "l": "atrazine N-dealkylase activity"}, {"i": "MetaCyc:R461-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110311", "l": "POLZ extends translesion synthesis (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24223", "l": "beta-myrcene + O2 + reduced [NADPH--hemoprotein reductase] <=> (4R)-ipsdienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250875", "l": "botF:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173636", "l": "Formation of classic pathway C5 convertase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16802", "l": "3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] => adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008864", "l": "formyltetrahydrofolate deformylase activity"}, {"i": "MetaCyc:FORMYLTHFDEFORMYL-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1799326", "l": "Signal-containing nascent peptide translocates to endoplasmic reticulum (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49545", "l": "(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O => 2-dehydro-3-deoxy-D-gluconate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57246", "l": "dGTP + H(+) + lactate => H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021451", "l": "NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607746", "l": "PKC-delta is activated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578777", "l": "DMPK phosphorylates PLN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694281", "l": "Encapsidation of SARS coronavirus genomic RNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44243", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol <=> a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + di-(9Z)-octadecenoylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34134", "l": "neryl diphosphate + olivetolate <=> cannabinerolate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176517", "l": "SULTs transfer (SO4)2- group to PREG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000170", "l": "sphingosine hydroxylase activity"}, {"i": "REACT:R-HSA-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38791", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14599", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+) => a CDP-1,2-diacyl-sn-glycerol + choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602473", "l": "Autocatalytic activation of MMP1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52354", "l": "(24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'-bisphosphate + H(+) => (24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36279", "l": "H(+) + NADH + O2 + theophylline = 3-methylxanthine + formaldehyde + H2O + NAD(+)"}, {"i": "EC:1.14.13.178", "l": "\"Methylxanthine N(1)-demethylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59183", "l": "5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O <=> 2 AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706354", "l": "Ubiquitination of FLT3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50707", "l": "1-propanol + NAD(+) <=> H(+) + NADH + propanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31161", "l": "3-oxohexadecanoyl-CoA + H(+) + NADH => (3S)-hydroxyhexadecanoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9649733", "l": "mature p21 RAS binds GDP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004448", "l": "isocitrate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849094", "l": "ARHGAP35 binds RASA1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47794", "l": "5-methylcytidine(4447) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(4447) in 28S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50301", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => all-trans-4-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.9.-", "l": "\"With a copper protein as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44410", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-517705", "l": "p-S318,221-HuR binds mRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237160", "l": "MTA is cleaved and phosphorylated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26338", "l": "L-homocysteine + S-methyl-L-methionine => H(+) + 2 L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53807", "l": "allodeoxycholoyl-CoA + ursodeoxycholate <=> allodeoxycholate + ursodeoxycholoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159194", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.36", "l": "\"Leishmanolysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605717", "l": "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62231", "l": "(E)-ascladiol + A <=> AH2 + patulin"}]}
{"type": "biolink:MolecularActivity", "ic": "78.047734625335977", "identifiers": [{"i": "GO:0140358", "l": "P-type transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693356", "l": "CEMIP hydrolyses HA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22773", "l": "L-fuconate => 2-dehydro-3-deoxy-L-fuconate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22283", "l": "O-demethylpuromycin + S-adenosyl-L-methionine <=> H(+) + puromycin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374909", "l": "Metabolism of Noradrenaline (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12162", "l": "3-dehydro-2-deoxy-D-gluconate + H(+) + NADH => 2-deoxy-D-gluconate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140842", "l": "n fibrin monomers -> fibrin multimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40798", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0034979", "l": "NAD-dependent protein deacetylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63171", "l": "fumarate + L-cysteine <=> S-(2-succino)-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53821", "l": "chenodeoxycholate + NADP(+) => 7-oxolithocholate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42520", "l": "uridine(2605) in 23S rRNA = pseudouridine(2605) in 23S rRNA"}, {"i": "EC:5.4.99.22", "l": "\"23S rRNA pseudouridine(2605) synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25239", "l": "ADP + CTP => ATP + CDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16340", "l": "a 3'-unsubstituted flavone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 3'-hydroxyflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13463", "l": "2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + 2 H2O + NADP(+) => 3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.32", "l": "\"Stem bromelain\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013435", "l": "RHOD auto-activates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38266", "l": "(2R,3S)-beta-methylmalyl-CoA <=> 2-methylfumaryl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.6", "l": "\"Exodeoxyribonuclease VII\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23030", "l": "acetyl-[ACP] + N(6)-carboxybiotinyl-L-lysyl-[protein] => malonyl-[ACP] + N(6)-biotinyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212222", "l": "PRC2 recruits DNA methyltransferases (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.14", "l": "\"Methyl-branched lipid omega-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0106019", "l": "phosphatidylinositol-4,5-bisphosphate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2106615", "l": "Removal of siRNA passenger strand (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110319", "l": "Elongation by POLH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944232", "l": "Association of procollagen type XII (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12112", "l": "indole-3-pyruvate + S-adenosyl-L-methionine = (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.47", "l": "\"Indolepyruvate C-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60075", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2 <=> 4beta-hydroxymethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16115", "l": "2 apo--[cyanocobalamin reductase] + 2 cyanocob(III)alamin + H(+) + NADPH => 2 cob(II)alamin--[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58468", "l": "2 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 O2 = 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16728", "l": "a phosphatidylglycerol phosphate + H2O <=> a phosphatidylglycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38552", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoate + O2 => (R)-2-hydroxyhexadecanoate + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52400", "l": "4-O-phospho-D-threonate + NAD(+) = 3-dehydro-4-O-phospho-L-erythronate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20083", "l": "hexanoate + methylamine => H2O + N-methylhexanamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54741", "l": "9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35955", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin B = 6-hydroxytryprostatin B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.118", "l": "\"Tryprostatin B 6-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.12", "l": "\"2,4-diaminopentanoate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727819", "l": "TAK1 phosphorylates MKK6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63422", "l": "cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate => 2-hydroxyethylphosphonate + CTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58549", "l": "2 L-ascorbate + N-(9Z,12Z,15Z)-octadecatrienoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39974", "l": "1-aminocyclopropane-1-carboxylate <=> 2-aminobut-2-enoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58714", "l": "H(+) + H2O + NAD(+) + rifampicin para-naphthoquinone carboxamide => NADH + O2 + rifampicin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11458", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534096", "l": "METAP1/2 demethylates GNAT1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004135", "l": "amylo-alpha-1,6-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47559", "l": "H2O + taurodeoxycholate <=> deoxycholate + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015667", "l": "site-specific DNA-methyltransferase (cytosine-N4-specific) activity"}, {"i": "RHEA:16857", "l": "a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.113", "l": "\"Site-specific DNA-methyltransferase (cytosine-N(4)-specific)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013006", "l": "RHOA:GTP translocates to the ER membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45134", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15690", "l": "H(+) + L-2,4-diaminobutanoate => CO2 + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030770", "l": "demethylmacrocin O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35868", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17904", "l": "S-adenosyl-L-methionine + xanthotoxol <=> H(+) + S-adenosyl-L-homocysteine + xanthotoxin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865280", "l": "TFAP2C homodimer binds the CDKN1A (p21) gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-688136", "l": "TNFAIP3 (A20) deubiquitinates RIP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201603", "l": "Caspase-mediated cleavage of PKC theta (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27629", "l": "D-erythrose 4-phosphate + D-xylulose 5-phosphate <=> beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.16", "l": "\"Succinate-semialdehyde dehydrogenase (NAD(P)(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661198", "l": "Defective SLCO1B3 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47677", "l": "ATP + N-acetyl-D-galactosamine => ADP + H(+) + N-acetyl-D-galactosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53479", "l": "1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> (6Z,9Z,12Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26387", "l": "(2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal => all-trans-8'-apo-beta-carotenal + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52870", "l": "17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 17alpha-estradiol + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684229", "l": "SUMO-p-N protein dimer binds genomic RNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65148", "l": "phloretin + UDP-alpha-D-glucose = H(+) + trilobatin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798748", "l": "Exocytosis of secretory granule lumen proteins (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871494", "l": "SORL1 binds APP(18-770) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956684", "l": "ITCH polyubiquitinates TP73 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951951", "l": "RUNX3 binds EP300 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13442", "l": "H2O + L-cysteate => H(+) + NH4(+) + pyruvate + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17686", "l": "H(+) + uracil 5-carboxylate => CO2 + uracil"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29924", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174121", "l": "Association of Securin with Cdc20:APC/C complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204863", "l": "Interaction of Tie2 with Ang2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10685", "l": "H2O + O-phospho-L-tyrosyl-[protein] => L-tyrosyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373087", "l": "Receptor CCR6 binds CCL20 ligand (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46065", "l": "(11E)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (6Z,11E)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33702", "l": "2 [Fe(II)-cytochrome b5] + C20 sphinganine + 2 H(+) + O2 <=> (4R)-hydroxyeicosasphinganine + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16051", "l": "adenosylcob(III)alamin + GMP + H(+) => adenosylcob(III)inamide-GDP + alpha-ribazole"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12813", "l": "L-glutamate = D-glutamate"}, {"i": "EC:5.1.1.3", "l": "\"Glutamate racemase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201603", "l": "Caspase-mediated cleavage of PKC theta (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917700", "l": "MVB Vesicle Formation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18472", "l": "an acyl-CoA + L-glutamine <=> an N(2)-acyl-L-glutamine + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11894", "l": "H(+) + nororientaline + S-adenosyl-L-homocysteine => 6-O-methylnorlaudanosoline + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849878", "l": "PSD-95 binds NMDA receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249392", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62508", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-517705", "l": "p-S318,221-HuR binds mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8867344", "l": "OMA1 hydrolyses OPA1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047004", "l": "UDP-N-acetylglucosamine 6-dehydrogenase activity"}, {"i": "RHEA:13325", "l": "H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine = 3 H(+) + 2 NADH + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate"}, {"i": "EC:1.1.1.136", "l": "\"UDP-N-acetylglucosamine 6-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59184", "l": "2,4-diacetylphloroglucinol + H2O = 2-acetylphloroglucinol + acetate"}, {"i": "EC:3.7.1.24", "l": "\"2,4-diacetylphloroglucinol hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21892", "l": "D-arabinose + NADP(+) = D-arabinono-1,4-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102745", "l": "dihydrogeranylgeranyl-PP reductase activity"}, {"i": "MetaCyc:RXN-7659"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53426", "l": "an N-acyl-sphingoid base + CoA + H(+) => a fatty acyl-CoA + a sphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30206", "l": "H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate <=> 2 GDP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052654", "l": "L-leucine transaminase activity"}, {"i": "KEGG.REACTION:R01090"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50585", "l": "13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) => 15-oxoprostaglandin E1 + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45545", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004082", "l": "bisphosphoglycerate mutase activity"}, {"i": "RHEA:17765", "l": "(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+)"}, {"i": "EC:5.4.2.4", "l": "\"Bisphosphoglycerate mutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047726", "l": "iron-cytochrome-c reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953111", "l": "E2F6 binds TFDP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450474", "l": "MK2 phosphorylates BRF1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50237", "l": "O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] => 17alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170674", "l": "Dissociation of the Gi alpha:G olf complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990411", "l": "hercynylcysteine sulfoxide lyase activity (ergothioneine-forming)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174444", "l": "Formation of C-strand Okazaki fragments (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64847", "l": "(2E)-geraniol + benzoyl-CoA <=> (2E)-geranyl benzoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2032781", "l": "WWTR1 (TAZ) binds TEAD (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857345", "l": "Activated CEBPB binds CDKN2B promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24951", "l": "3-hydroxy-3-methylglutarate + malonyl-CoA <=> (3S)-hydroxy-3-methylglutaryl-CoA + malonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40537", "l": "2 H2O + novapikromycin + 4 oxidized [2Fe-2S]-[ferredoxin] => 4 H(+) + narbomycin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16126", "l": "ATP + D-fructose => ADP + D-fructose 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38284", "l": "itaconate + succinyl-CoA => itaconyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008957", "l": "phenylacetaldehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58603", "l": "2 L-ascorbate + N-(9Z-octadecenoyl)glycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-(9Z-octadecenoyl)-(2S)-hydroxyglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33076", "l": "3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine => 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003951", "l": "NAD+ kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.19", "l": "\"Carboxypeptidase Taq\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44905", "l": "alpha-D-glucose 6-phosphate + H2O => alpha-D-glucose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25022", "l": "CTP + riboflavin => CDP + FMN + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35747", "l": "(2E,6E)-farnesyl diphosphate = 7-epizingiberene + diphosphate"}, {"i": "EC:4.2.3.142", "l": "\"7-epizingiberene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018852", "l": "dichloromuconate cycloisomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247844", "l": "WNT ligands traffic to the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170149", "l": "Translocation of active Cdc25C to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4088281", "l": "Endorepellin binds KDR (VEGFR2) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3149492", "l": "cob(II)alamin dissociates from MMACHC:MMADHC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56815", "l": "2-oxoglutarate + chloride + H(+) + L-threonyl-[peptidyl-carrier protein] + O2 <=> 4-chloro-L-threonyl-[peptidyl-carrier protein] + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59634", "l": "D-xylobiono-1,5-lactone + H2O2 => D-xylobiose + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22449", "l": "ATP + pseudouridine => ADP + H(+) + psi-UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1474266", "l": "Formation of collagen fibrils (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56116", "l": "2-all-trans-decaprenylphenol + H(+) + NADPH + O2 = 3-(all-trans-decaprenyl)benzene-1,2-diol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33295", "l": "L-hexahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-9-(methylsulfanyl)nonanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389348", "l": "Activation of Rac1 by pVav1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45723", "l": "N-hexadecanoylsphing-4-enine(in) <=> N-hexadecanoylsphing-4-enine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352867", "l": "glucose [cytosol] <=> glucose [extracellular] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2172123", "l": "Interaction of SIGLEC14/15/16 and DAP12 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16459", "l": "2-hydroxy-3-oxosuccinate + H(+) + NADH => (2R,3S)-tartrate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39391", "l": "(2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH = (17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.19"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807077", "l": "NR2E1 associated with transcription repressors binds PTEN promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34015", "l": "ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2 = ergosterol + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018678", "l": "4-hydroxybenzoate 1-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700190", "l": "ALK mutants bind SHC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41486", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163769", "l": "Activation of PP2A by Xylulose-5-phosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58242", "l": "ADP-D-ribose + L-cysteinyl-[protein] => H2O + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64064", "l": "(1R,2R)-pseudoephedrine + NAD(+) = (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13311", "l": "4-hydroxy-3-methoxybenzoate + 2 H(+) + NADH => H2O + NAD(+) + vanillin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39962", "l": "1-hexadecanoylglycerol + H2O <=> glycerol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52726", "l": "adenosine 3',5'-bisphosphate + an omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+) => 3'-phosphoadenylyl sulfate + an aliphatic desulfo-glucosinolate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30322", "l": "H(+) + NADH + O2 + theobromine <=> 7-methylxanthine + formaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11981", "l": "2 L-gamma-glutamyl-L-cysteine + NADP(+) => bis-gamma-glutamylcystine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19365", "l": "ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate + H(+)"}, {"i": "EC:2.7.1.19", "l": "\"Phosphoribulokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173542", "l": "SMURF2 ubiquitinates SMAD2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14327", "l": "daphnin + H(+) + UDP => 7,8-dihydroxycoumarin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30117", "l": "decanoate + H(+) + holo-[ACP] => decanoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190790", "l": "Assembly of gap junction plaques (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21130", "l": "24-methylene-5alpha-cholest-8-en-3beta-ol + H(+) + S-adenosyl-L-homocysteine => 5alpha-cholesta-8,24-dien-3beta-ol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433451", "l": "JAK2 binds to p-KIT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395801", "l": "Phosphorylation of LAT by p-SYK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29072", "l": "a ubiquinone + formate + H(+) => a ubiquinol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53277", "l": "17beta-hydroxy-3,19-dioxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] => 17beta-hydroxy-3-oxo-19-nor-5alpha-androst-1-ene + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141409", "l": "Mad1 binds kinetochore (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187293", "l": "SMAD2/3:SMAD4 complex positively regulates JUNB transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725342", "l": "NPM-ALK-dependent JUNB gene transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036313", "l": "phosphatidylinositol 3-kinase catalytic subunit binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17073", "l": "acetyl-CoA + cortisol = CoA + cortisol 21-acetate"}, {"i": "EC:2.3.1.27", "l": "\"Cortisol O-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11234", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + sulfate => 3'-phosphoadenylyl sulfate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53498", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate => 1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57978", "l": "(20S)-ginsenoside C-K + H(+) + UDP => (20S)-protopanaxadiol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030369", "l": "ICAM-3 receptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "64.97931804346041", "identifiers": [{"i": "GO:0016831", "l": "carboxy-lyase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102083", "l": "7,8-dihydromonapterin aldolase activity"}, {"i": "MetaCyc:RXN-10857"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6790038", "l": "Expression of HSP90B1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24465", "l": "2-dehydro-3-deoxy-6-phospho-D-galactonate => D-glyceraldehyde 3-phosphate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "80.661393760018115", "identifiers": [{"i": "GO:0010334", "l": "sesquiterpene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2250301", "l": "Formation of lysyl-pyrrole cross-links (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12485", "l": "a ribonucleoside 5'-phosphate + H2O => a ribonucleoside + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706315", "l": "Active FLT3 binds to SH2B3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53870", "l": "1-hydroxyphenazine + CO2 + H2O + NAD(+) => 2 H(+) + NADH + O2 + phenazine-1-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419254", "l": "5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663156", "l": "p-BMAL1:p-CLOCK,NPAS2 binds PPARA gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951486", "l": "CD46 binds C4b (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047490", "l": "pectin lyase activity"}, {"i": "MetaCyc:4.2.2.10-RXN"}, {"i": "EC:4.2.2.10", "l": "\"Pectin lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34419", "l": "(+)-lariciresinol + NADP(+) = (+)-pinoresinol + H(+) + NADPH"}, {"i": "EC:1.23.1.1", "l": "\"(+)-pinoresinol reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198714", "l": "ERK5 translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174757", "l": "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49940", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2 = (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2"}, {"i": "EC:1.10.3.16", "l": "\"Dihydrophenazinedicarboxylate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60238", "l": "2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015055", "l": "secretin receptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "72.438504002572699", "identifiers": [{"i": "GO:0016661", "l": "oxidoreductase activity, acting on other nitrogenous compounds as donors"}, {"i": "EC:1.7.-.-", "l": "\"Acting on other nitrogenous compounds as donors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45995", "l": "(3R)-3-hydroxydecanoyl-CoA <=> (2E)-decenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.99.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12223", "l": "H2O + L-leucine + NAD(+) <=> 4-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22189", "l": "an (R)-2-haloacid + H2O => a (2S)-2-hydroxycarboxylate + a halide anion + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848077", "l": "PTK6 phosphorylates STAP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13961", "l": "ATP + H2O + Mg(2+) + protoporphyrin IX = ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate"}, {"i": "EC:6.6.1.1", "l": "\"Magnesium chelatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44804", "l": "1,4-dihydroxy-2-naphthoate + all-trans-nonaprenyl diphosphate + H(+) = 2-demethylmenaquinol-9 + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15233", "l": "[Fe(III)cytochrome c] + H2O + nitric oxide = [Fe(II)cytochrome c] + 2 H(+) + nitrite"}, {"i": "EC:1.7.2.1", "l": "\"Nitrite reductase (NO-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2032770", "l": "Translocation of YAP1 to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29923", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A = ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17527", "l": "NH4(+) + urea-1-carboxylate => biuret + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30708", "l": "putrescine + pyruvate => 4-aminobutanal + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449200", "l": "Interaction of ABL1 with CDO complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.109", "l": "\"Arginine N-succinyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33236", "l": "2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 => 3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34233", "l": "4-nitro-6-oxohepta-2,4-dienedioate + H(+) => 5-nitrosalicylate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14474", "l": "a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) => a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63192", "l": "[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + O2 = glycine betaine + 2 H(+) + phosphate"}, {"i": "EC:1.13.11.90", "l": "\"(1-hydroxy-2-(trimethylamino)ethyl)phosphonate dioxygenase (glycine-betaine-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373073", "l": "Receptors CCR1, 2 and 8 bind CCL16 ligand (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174731", "l": "Degradation of newly synthesized ApoB-48 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682388", "l": "Autophagosome maturation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448962", "l": "Heterodimerization of E proteins with Myod (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247847", "l": "WLS is endocytosed to the early endosome (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938231", "l": "RUNX1:CBFB binds CREBBP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2317332", "l": "PIP3 recruits AKT to the membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44444", "l": "a 1,2-diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60747", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-pyrethrolone <=> CoA + pyrethrin I"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203567", "l": "palmitoylation of eNOS (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28068", "l": "alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070027", "l": "carbon monoxide sensor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62467", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O <=> 2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50757", "l": "NADP(+) + reduced [flavodoxin] => 2 H(+) + NADPH + oxidized [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004925", "l": "prolactin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2129353", "l": "Tropoelastin associates with microfibrils (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65952", "l": "2 a quinone + H(+) + NADH = 2 a 1,4-benzosemiquinone + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28761", "l": "alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP + H(+) => beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5672011", "l": "p-AMPK:AMP binds the ULK complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63571", "l": "beta-casomorphin-7 + H2O <=> beta-casomorphin-6 + L-isoleucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-996727", "l": "REST recruits the BHC complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033834", "l": "kaempferol 3-O-galactosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689544", "l": "UCHL5 binds INO80 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444572", "l": "Zinc is an agonist of GPR39 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139906", "l": "Activation of BAD by calcineurin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52258", "l": "5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide c + H(+) + L-methionine => a 7(1)-hydroxybacteriochlorophyllide c + H2O + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64238", "l": "atrochrysone carboxylate + H(+) + holo-[ACP] => atrochrysone carboxyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41629", "l": "geranylgeranyl diphosphate + H2O => cyclooctat-9-en-7-ol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211874", "l": "CYP2S1 4-hydroxylates atRA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15389", "l": "ATP = 3',5'-cyclic AMP + diphosphate"}, {"i": "EC:4.6.1.1", "l": "\"Adenylate cyclase\""}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0071723", "l": "lipopeptide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012651", "l": "p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675194", "l": "Activated MAPK phosphorylates RAF1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47766", "l": "2'-O-methyluridine(1369) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(1369) in 16S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62290", "l": "(S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + diphosphate => (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37324", "l": "glycyl-L-methionine + H2O => glycine + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380782", "l": "STAT binds to the active receptor (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797100", "l": "CCNK binds CDK13 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161794", "l": "Arachidonic acid is converted to HXA3/B3 by ALOX12 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30539", "l": "(R)-carnitinyl-CoA = (S)-carnitinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43122", "l": "CO2 + succinate + urate => 2-oxoglutarate + O2 + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862700", "l": "CMKLR1 binds Resolvin E1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58783", "l": "a 5'-triphospho-guanosine-ribonucleotide-snRNA + S-adenosyl-L-methionine <=> a 5'-methyltriphosphate-guanosine-ribonucleotide-snRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427528", "l": "Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047393", "l": "glycerol-1,2-cyclic-phosphate 2-phosphodiesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14578", "l": "(R)-carnitine => crotonobetaine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20412", "l": "alpha-D-glucose 1-phosphate + riboflavin <=> D-glucose + FMN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-434650", "l": "MATEs mediate extrusion of xenobiotics (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0018169", "l": "ribosomal S6-glutamic acid ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63992", "l": "5-fluorocytidine + ATP = 5-fluorocytidine 5'-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.19", "l": "\"Lycopene beta-cyclase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37579", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "81.790986234327661", "identifiers": [{"i": "GO:0015929", "l": "hexosaminidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56118", "l": "3-(all-trans-decaprenyl)benzene-1,2-diol + H2O + NADP(+) => 2-all-trans-decaprenylphenol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60306", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2484822", "l": "Kinetochore assembly (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709547", "l": "ESTG binds ESR2:chaperone complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21376", "l": "3-(4-hydroxyphenyl)pyruvate + O2 = (S)-4-hydroxymandelate + CO2"}, {"i": "EC:1.13.11.46", "l": "\"4-hydroxymandelate synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050019", "l": "L-arabinitol 4-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72130", "l": "Formation of an intermediate Spliceosomal C (Bact) complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390673", "l": "CHRM2,4 bind acetylcholine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53810", "l": "(24S)-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholestanol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37015", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013006", "l": "RHOA:GTP translocates to the ER membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168140", "l": "Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17867", "l": "6,7-dihydropteridine + H(+) + NADPH => 5,6,7,8-tetrahydropteridine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59459", "l": "NADP(+) + tetradecan-1-ol <=> H(+) + NADPH + tetradecanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21702", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate => 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694454", "l": "Replication transcription complex binds SARS-CoV-2 genomic RNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0019111", "l": "phenanthrol sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.12.1", "l": "\"5' to 3' exodeoxyribonuclease (nucleoside 3'-phosphate-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76466", "l": "CYP4A11 12-hydroxylates DDCX (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73932", "l": "Resynthesis of excised residue by POLB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22328", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29178", "l": "2 O2 + ubiquinol-8 <=> 2 H(+) + 2 superoxide + ubiquinone-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19953", "l": "a 2-oxocarboxylate + L-alanine = an L-alpha-amino acid + pyruvate"}, {"i": "EC:2.6.1.12", "l": "\"Alanine--oxo-acid transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375302", "l": "Kinetochore capture of astral microtubules (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848975", "l": "PTK6 phosphorylates KHDRBS1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296043", "l": "Activation of HCN channels (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35815", "l": "4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) = 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55775", "l": "a jasmonate + an L-alpha-amino acid + ATP <=> a jasmonyl-L-amino acid + AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38630", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA <=> 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981680", "l": "C4b binding protein displaces C2a (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42474", "l": "2,2',3-trihydroxydiphenyl ether + H(+) + NAD(+) => dibenzo-p-dioxin + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45947", "l": "12-methyltridecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(13-methyl-2-oxotetradecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11129", "l": "4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA => 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51775", "l": "dimethylallyl diphosphate + phlorisobutanophenone <=> 4-prenylphlorisobutanophenone + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60201", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47748", "l": "a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n Na(+)(out) + NAD(+)"}, {"i": "EC:7.2.1.1", "l": "\"NADH:ubiquinone reductase (Na(+)-transporting)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26298", "l": "1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH => 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34628", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56012", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) = beta-D-mannose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021946", "l": "MECP2 binds GPRIN1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2564824", "l": "NADPH reduces NDOR1:CIAPIN1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53577", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653886", "l": "B4GALT1 binds LALBA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25914", "l": "5-hydroxyquinolin-2(1H)-one + AH2 => A + H2O + quinolin-5-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65182", "l": "A + H2O + preaustinoid A => AH2 + O2 + protoaustinoid B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23826", "l": "2,3-dihydroxybenzoate + H(+) + NADH => (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953013", "l": "E2F7 binds E2F8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22506", "l": "adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3'-bissulfate => 3'-phosphoadenylyl sulfate + quercetin 3-sulfate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045174", "l": "glutathione dehydrogenase (ascorbate) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52782", "l": "2-sulfenohercynine + NH4(+) + pyruvate => H2O + S-(hercyn-2-yl)-L-cysteine S-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32738", "l": "1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine <=> 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607751", "l": "TRAF6 oligomerizes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32653", "l": "erythromycin B + H(+) + S-adenosyl-L-homocysteine => erythromycin D + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24037", "l": "a ribonucleoside 5'-phosphate + ATP => a ribonucleoside 5'-diphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10851", "l": "an [alpha-factor](in) + ATP + H2O <=> ADP + an [alpha-factor](out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29124", "l": "nitrate(out) + ubiquinol-8(in) => H2O(out) + nitrite(out) + ubiquinone-8(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388833", "l": "Phosphorylation of CTLA-4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48594", "l": "a quinol + CO2 => a quinone + formate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30861", "l": "dIDP + H(+) + phosphate => dITP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2995330", "l": "COX10 transforms heme to heme O (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40931", "l": "2-oxoglutarate + L-ornithine + O2 = (3S)-3-hydroxy-L-ornithine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37422", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428888", "l": "Phosphorylation of ROBO1 by ABL kinase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45218", "l": "[Co(I) dimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M => [methyl-Co(III) dimethylamine-specific corrinoid protein] + coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109813", "l": "GRB2-1 binds SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797090", "l": "CCNK binds CDK12 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047724", "l": "inosine nucleosidase activity"}, {"i": "RHEA:16657", "l": "H2O + inosine = D-ribose + hypoxanthine"}, {"i": "EC:3.2.2.2", "l": "\"Inosine nucleosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198513", "l": "Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33113", "l": "beta-copaene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164840", "l": "ADP and Pi bind to ATPase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-879674", "l": "CD97 binds CD55 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787820", "l": "IL34 dimer binds CSF1R (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-481009", "l": "Exocytosis of platelet dense granule content (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48540", "l": "1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O = dodecanoate + dodecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15996", "l": "anthraniloyl-CoA + 2 H(+) + 2 NADPH + O2 <=> 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28104", "l": "D-mannose + GDP + H(+) => GDP-alpha-D-mannose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34176", "l": "2-hydroxybenzoyl-CoA + malonyl-CoA => 4-hydroxycoumarin + CO2 + 2 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64408", "l": "H(+)(out) + N-acetylmuramyl-L-alanyl-D-isoglutamine(out) = H(+)(in) + N-acetylmuramyl-L-alanyl-D-isoglutamine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179293", "l": "UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106312", "l": "methylenetetrahydrofolate reductase NADH activity"}, {"i": "RHEA:19821", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191784", "l": "snRNA Cap hypermethylation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429497", "l": "SLP-76 stimulates PLC gamma 2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218822", "l": "CRK binds BCAR1 and or PXN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696271", "l": "RND1 binds effectors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12075", "l": "an (S)-2-haloacid + H2O <=> a (2S)-2-hydroxycarboxylate + a halide anion + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607043", "l": "factor VIIIa associates with cell membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52976", "l": "a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] = a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189439", "l": "ALAD condenses 2 dALAs to form PBG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56677", "l": "dihydroferuloyl-CoA + NADP(+) => (E)-feruloyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48141", "l": "2 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] => 2 oxidized [2Fe-2S]-[ferredoxin] + red chlorophyll catabolite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013159", "l": "CDC42 GEFs activate CDC42 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2032770", "l": "Translocation of YAP1 to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41139", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48573", "l": "3,5-dichlorocatechol + O2 => (2E,4E)-2,4-dichloromuconate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63144", "l": "H2O + N-(15Z-tetracosenoyl)-ethanolamine = (15Z)-tetracosenoate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18817", "l": "acetyl-CoA + malonate = acetate + malonyl-CoA"}, {"i": "EC:2.8.3.3", "l": "\"Malonate CoA-transferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009029", "l": "tetraacyldisaccharide 4'-kinase activity"}, {"i": "RHEA:20700", "l": "ATP + lipid A disaccharide (E. coli) = ADP + H(+) + lipid IVA (E. coli)"}, {"i": "EC:2.7.1.130", "l": "\"Tetraacyldisaccharide 4'-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2248891", "l": "Active ARSA translocates to the lysosome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6800793", "l": "PIDD1 translocates to the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11144", "l": "GDP-alpha-D-mannose = GDP-beta-L-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938231", "l": "RUNX1:CBFB binds CREBBP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687377", "l": "Defective RB1 does not form a complex with SKP2 and FZR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191784", "l": "snRNA Cap hypermethylation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55384", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate = 6 diphosphate + tetra-trans,hexa-cis-undecaprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64762", "l": "ethanethiol + NH4(+) + pyruvate => H2O + S-ethyl-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047428", "l": "arylacetonitrilase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379464", "l": "COMT transfers Met to DOPAC to form HVA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-179417", "l": "Multiubiquitination of Nek2A (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18995", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39040", "l": "an omega-oxo fatty acid + H2O + NAD(+) => a dicarboxylate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29912", "l": "ATP + H2O + N-acetyl-D-glucosamine(in) => ADP + H(+) + N-acetyl-D-glucosamine(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53263", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 1beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65129", "l": "1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784189", "l": "JAKs bind LIFR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38041", "l": "2 [Fe(III)-cytochrome b5] + a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380233", "l": "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380780", "l": "Activation of Src (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25283", "l": "O2 + reduced [NADPH--hemoprotein reductase] + squalene => (S)-2,3-epoxysqualene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1251944", "l": "PLCG1 binds to p-ERBB2:p-EGFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210277", "l": "Interaction of PECAM-1 and SHP-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9649735", "l": "Intrinsic nucleotide exchange on RAS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15148", "l": "D-maltose <=> alpha,alpha-trehalose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50963", "l": "cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine <=> H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16320", "l": "(S)-indan-1-ol + NAD(+) <=> H(+) + indan-1-one + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56942", "l": "2-(methylsulfanyl)acetaldehyde + dihydroxyacetone phosphate => S-methyl-5-thio-D-ribulose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14963", "l": "formate + glutathione + H(+) => H2O + S-formylglutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34818", "l": "2 NADP(+) + tetrahydrocurcumin <=> curcumin + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36390", "l": "carbamoyl adenylate + kanamycin A <=> 6''-O-carbamoylkanamycin A + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981931", "l": "RAC1 and CDC42 activate PAK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622738", "l": "CAT gene expression is stimulated by FOXO3,FOXO6,(FOXO1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086410", "l": "CDK1 phosphorylates BORA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64823", "l": "2-phenylacetamide + H2O <=> 2-phenylacetate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047638", "l": "albendazole monooxygenase activity"}, {"i": "KEGG.REACTION:R03712"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23435", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47663", "l": "acetyl-CoA + L-methionine sulfoximine <=> CoA + H(+) + N-acetyl-L-methionine sulfoximine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46292", "l": "a 5'-end triphospho-(purine-ribonucleoside) in mRNA + GDP + H(+) = a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3204303", "l": "MRE11 binds cytosolic DNA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801776", "l": "REG3A binds bacterial phospholipids (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12594", "l": "a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29685", "l": "alpha-D-glucose 1-phosphate + alpha-maltopentaose => alpha-maltohexaose + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050097", "l": "methylaspartate mutase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048472", "l": "threonine-phosphate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47179", "l": "(2R)-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36457", "l": "ADP + H(+) + L-alanylglycine(in) + phosphate => ATP + H2O + L-alanylglycine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19172", "l": "L-serine <=> NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44739", "l": "acetyl-CoA + dihydroxyacetone phosphate <=> 3-hydroxy-2,4-dioxopentyl phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41005", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59963", "l": "N(alpha)-acetyl-D-methionine <=> N(alpha)-acetyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24899", "l": "2 GTP => cyclic di-3',5'-guanylate + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34837", "l": "a 1,2-diacyl-sn-glycerol + N-acyl-4-hydroxy-15-methylhexadecasphinganine-1-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-4-hydroxy-15-methylhexadecasphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26262", "l": "H2O + isopimara-7,15-dienal + NADP(+) => 2 H(+) + isopimarate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43975", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> H(+) + hexadecanoate + hexadecanoyl-glycero-3-phospho-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48990", "l": "2'-N-hydroxyrifampicin + H2O + NAD(+) => NADH + O2 + rifampicin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63616", "l": "prunetin + UDP-alpha-D-glucuronate = H(+) + prunetin-C(8)-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43252", "l": "1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016231", "l": "beta-N-acetylglucosaminidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34989", "l": "(S)-lactate(out) => (S)-lactate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874083", "l": "p-Y397-PTK2 binds SRC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51677", "l": "[protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide => [protein]-dithiol + 2 AH2 + H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004720", "l": "protein-lysine 6-oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40210", "l": "(2E)-tetradecenedioyl-CoA + H2O <=> (3S)-hydroxytetradecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40250", "l": "H2O + rhodomycin D <=> 10-carboxy-13-deoxycarminomycin + H(+) + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48808", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15883", "l": "ADP + H(+) + O-phospho-L-seryl-[Fas-activated protein] => ATP + L-seryl-[Fas-activated protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41555", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O <=> diphosphate + ophiobolin F"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83650", "l": "FasL:Fas binds FADD (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8954117", "l": "E2F6:TFDP1 binds EPC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31000", "l": "(S)-2,3-epoxysqualene => cucurbitadienol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22353", "l": "H(+) + L-lysine => cadaverine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205115", "l": "NGF:p75NTR complex binds to NRAGE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450975", "l": "isocitrate <=> citrate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43282", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51201", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-retinylidene-N-retinylethanolamine => H2O + N-retinylidene-N-retinylphosphatidylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.4.1.6", "l": "\"Acetone carboxylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008854", "l": "exodeoxyribonuclease V activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40644", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036033", "l": "mediator complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72671", "l": "eIF5B:GTP is hydrolyzed and released (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38514", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948226", "l": "Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22398", "l": "glycolaldehyde + guaiacol + H2O + vanillin => 1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140492", "l": "metal-dependent deubiquitinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59127", "l": "(S)-2,3-diaminopropanoate + ATP + citrate <=> 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42684", "l": "H2O + L-gamma-glutamyl-hercynylcysteine S-oxide = L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide"}, {"i": "EC:3.5.1.118", "l": "\"Gamma-glutamyl hercynylcysteine S-oxide hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139898", "l": "Caspase-8 activates BID by cleavage (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9678925", "l": "NR3C1 binds NR3C1 agonists (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199910", "l": "MSK1 activates ATF1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33628", "l": "ATP + CoA + decanoate => AMP + decanoyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-976801", "l": "Complement factor I complex formation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66323", "l": "2',3'-cGAMP(out) <=> 2',3'-cGAMP(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52035", "l": "H2O + L-isoleucine-(+)-7-isojasmonate <=> (+)-7-isojasmonate + L-isoleucine"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0016248", "l": "channel inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443439", "l": "c-Src binds Raf1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31003", "l": "(S)-2,3-epoxysqualene = germanicol"}, {"i": "EC:5.4.99.34", "l": "\"Germanicol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50693", "l": "ADP-alpha-D-glucose + alpha-D-glucose 1-phosphate => ADP + alpha-maltose 1-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51745", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A => a 1,2-diacyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60560", "l": "L-methionyl-[protein] + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12384", "l": "5,6-dihydrouracil + O2 = H2O2 + uracil"}, {"i": "EC:1.3.3.7", "l": "\"Dihydrouracil oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37377", "l": "1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18718", "l": "3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine => 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38896", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56984", "l": "(2E,6E)-farnesyl diphosphate + H2O = (6E)-nerolidol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45968", "l": "androst-4-ene-3,17-dione + H(+) + NADH + O2 = 9alpha-hydroxy-androst-4-ene-3,17-dione + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48077", "l": "a primary alcohol + N,N-dimethyl-4-nitrosoaniline => 4-(hydroxylamino)-N,N-dimethylaniline + an aldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37527", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30119", "l": "dodecanoyl-[ACP] + H2O = dodecanoate + H(+) + holo-[ACP]"}, {"i": "EC:3.1.2.21", "l": "\"Dodecanoyl-[acyl-carrier-protein] hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372697", "l": "Crk binding to p130cas (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879942", "l": "The receptor is activated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16724", "l": "5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-Glu)(n) <=> 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031861", "l": "prolactin-releasing peptide receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65898", "l": "glycine + H2O + kynurenate => glyoxylate + L-kynurenine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008707", "l": "4-phytase activity"}, {"i": "RHEA:20960", "l": "1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate"}, {"i": "EC:3.1.3.26", "l": "\"4-phytase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.55", "l": "\"Caspase-2\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9655071", "l": "Transcription of DDIT3 (CHOP, GADD153) in response to heme deficiency (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25029", "l": "ADP-D-ribose 1''-phosphate + H2O = ADP-D-ribose + phosphate"}, {"i": "EC:3.1.3.84", "l": "\"ADP-ribose 1''-phosphate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204773", "l": "Interaction of Tie2 and Grb7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54350", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14124", "l": "3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45385", "l": "H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5631885", "l": "PRDX1 overoxidizes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49263", "l": "D-galactose(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-galactose 6-phosphate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37531", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63333", "l": "alpha-L-arabinose => beta-L-arabinose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626816", "l": "PIN1 binds p-S345-NCF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228840", "l": "Defective IKBKB (IKK2) does not form a complex with IKBKA and IKBKG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102162", "l": "all-trans-8'-apo-beta-carotenal 15,15'-oxygenase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371582", "l": "HSBP1 binds HSF1 trimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16161", "l": "2 [Fe(III)-leghemoglobin] + NADH = 2 [Fe(II)-leghemoglobin] + H(+) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0019766", "l": "IgA receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35873", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034862", "l": "Activated NTRK3 binds SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250220", "l": "Homodimerization of ERBB4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047489", "l": "pectate disaccharide-lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11266", "l": "H2O2 + NAD(+) => H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54512", "l": "peregrinol diphosphate = (13R)-9,13-epoxylabd-14-ene + diphosphate"}, {"i": "EC:4.2.3.189", "l": "\"9,13-epoxylabda-14-ene synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009899", "l": "ent-kaurene synthase activity"}, {"i": "RHEA:22220", "l": "ent-copalyl diphosphate = diphosphate + ent-kaur-16-ene"}, {"i": "EC:4.2.3.19", "l": "\"Ent-kaurene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11221", "l": "a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-561072", "l": "OCT3 mediates renal uptake of organic cations (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9690494", "l": "RHOB translocates to the endosome membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9035227", "l": "TXN2 binds CysS248-MPST (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637795", "l": "Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42449", "l": "(R)-2-hydroxyglutaryl-CoA => (2E)-glutaconyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168638", "l": "Activated IKK phosphorylates I-kappaB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16010", "l": "ATP + formate => ADP + formyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76466", "l": "CYP4A11 12-hydroxylates DDCX (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43822", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176700", "l": "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14959", "l": "(11Z)-tetradecenoyl-CoA + 2 H2O + NAD(+) => H(+) + NADH + O2 + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69053", "l": "RFC binding displaces Pol Alpha (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14441", "l": "acetyl-CoA + gentamicin C = CoA + H(+) + N(3)-acetylgentamycin C"}, {"i": "EC:2.3.1.60", "l": "\"Gentamicin 3-N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36687", "l": "hexadecanoyl-CoA + sphing-4-enine = CoA + H(+) + N-hexadecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64803", "l": "NAD(+) + S-(2-aminoethyl)-L-cysteine <=> (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + 2 H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159733", "l": "Furin cleaves pro-factor X to factor X (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9696267", "l": "RND3 binds GTP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31244", "l": "H2O + L-4-hydroxyglutamate semialdehyde + NAD(+) => (4S)-4-hydroxy-L-glutamate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58500", "l": "glycine betaine + H(+) + NADH + O2 = glyoxylate + H2O + NAD(+) + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "ic": "80.155824608458104", "identifiers": [{"i": "GO:0046857", "l": "oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor"}, {"i": "EC:1.7.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12140", "l": "a 2'-deoxyribonucleoside + ATP = a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016990", "l": "arginine deiminase activity"}, {"i": "RHEA:19597", "l": "H2O + L-arginine = L-citrulline + NH4(+)"}, {"i": "EC:3.5.3.6", "l": "\"Arginine deiminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54989", "l": "4 e(-) + 4 H(+)(in) + O2(in) => 2 H2O(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000263", "l": "TCII:Cbl is degraded to release Cbl (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20227", "l": "(E)-ferulate + H(+) + S-adenosyl-L-homocysteine => (E)-caffeate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16322", "l": "(S)-indan-1-ol + NADP(+) => H(+) + indan-1-one + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701488", "l": "Active ALK phosphorylates JAK3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.100"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46196", "l": "O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60999", "l": "H2O + L-leucine + O2 <=> 4-methyl-2-oxopentanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5627775", "l": "Autophosphorylation of PAK1,2,3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20335", "l": "ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase] => ATP + L-seryl-[acetyl-CoA carboxylase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848864", "l": "PTK6 binds ARAP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10286", "l": "(3R)-beta-leucine => L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437999", "l": "Phosphorylation of MKK4 by activated TAK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11021", "l": "1D-myo-inositol 1,4,5-trisphosphate + ATP => 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12649", "l": "L-rhamnofuranose + NAD(+) = H(+) + L-rhamnono-1,4-lactone + NADH"}, {"i": "EC:1.1.1.173", "l": "\"L-rhamnose 1-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5228992", "l": "ROCK1,ROCK2 are activated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48561", "l": "H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate => D-ribose 5-phosphate + N(6)-dimethylallyladenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44352", "l": "ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate = ADP + dapdiamide C + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65526", "l": "9-cis-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9-cis-retinal + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798373", "l": "MDM2 ubiquitinates DYRK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17324", "l": "L-tryptophan + S-adenosyl-L-methionine <=> 2-methyl-L-tryptophan + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23601", "l": "2-oxoglutarate + L-2-aminohexanoate => 2-oxohexanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52497", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23576", "l": "(R)-N-methylcoclaurine + (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] = berbamunine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.19.66", "l": "\"Berbamunine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56732", "l": "4,4-dihydroxy-all-trans-beta-carotene = echinenone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110219", "l": "Cleavage of thymine by TDG glycosylase (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1900750", "l": "oligopeptide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209163", "l": "CI transports from the cytosol to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52950", "l": "deoxycholoyl-24-O-(beta-D-glucuronate) + UDP => deoxycholate + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878603", "l": "SSC5D binds ligands (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11661", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O => a 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141367", "l": "Myristoylation of tBID by NMT1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46770", "l": "a 1-acyl-2-[(9Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050198", "l": "pinosylvin synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9011983", "l": "Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67154", "l": "L-cysteinyl-[NO transferase protein] + S-nitroso-L-cysteinyl-[protein] => L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[NO transferase protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202709", "l": "JAM2 dimerises (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694522", "l": "Inner coat assembly and cargo binding (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49235", "l": "D-mannose(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-mannose 6-phosphate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67035", "l": "4,8-dihydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,5,8-trihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935930", "l": "miR-18a binds RUNX1 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023346", "l": "MECP2 binds NOTCH1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47060", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47204", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3769383", "l": "CBY1 binds beta-catenin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10929", "l": "ent-kaur-16-en-19-al + O2 + reduced [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19719", "l": "2-phenylethylamine + CO2 => H(+) + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56101", "l": "[small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+) => [small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22157", "l": "GDP + H2O => GMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624956", "l": "PDE6D binds INPP5E (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944223", "l": "Association of procollagen type V (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-398184", "l": "LARG activation by G alpha 12/13 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23820", "l": "GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O"}, {"i": "EC:4.2.1.47", "l": "\"GDP-mannose 4,6-dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702607", "l": "pexidartinib-resistant FLT3 mutants don't bind pexidartinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5632649", "l": "Hh-Npp binds GAS1 and PTCH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28632", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate => 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050648", "l": "5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20699", "l": "2 H(+) + 2 superoxide <=> H2O2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65634", "l": "an N-tetracosanoyl-sphingoid base + CoA + H(+) => a sphingoid base + tetracosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35728", "l": "dodecanoyl-CoA + sn-glycerol 3-phosphate => 1-dodecanoyl-sn-glycerol 3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709842", "l": "MAVS binds TOMM70 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70899", "l": "histidine => urocanate + NH4+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9626817", "l": "PKC phosphorylates NCF1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36966", "l": "(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-921155", "l": "p-STAT5 dissociates from the receptor complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15618", "l": "[Fe(II)cytochrome c] + Fe(3+) => [Fe(III)cytochrome c] + Fe(2+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40413", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-CDP + myo-inositol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033800", "l": "isoflavone 7-O-methyltransferase activity"}, {"i": "RHEA:17933", "l": "a 7-hydroxyisoflavone + S-adenosyl-L-methionine = a 7-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.150", "l": "\"Isoflavone 7-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694442", "l": "CNIH2,3 bind GRIA1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58388", "l": "4-aminobenzoate + all-trans-hexaprenyl diphosphate = 4-amino-3-all-trans-hexaprenylbenzoate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.36", "l": "\"Signal peptidase II\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191303", "l": "FDPS dimer transfers IPPP to GPP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37073", "l": "2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine => [sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374662", "l": "Translocation of Ezrin to plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868071", "l": "Clathrin recruits PIK3C2A (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63805", "l": "GDP-beta-L-gulose => GDP-beta-L-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209924", "l": "Dopa is decarboxylated to dopamine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.1", "l": "\"Anthranilate 1,2-dioxygenase (deaminating, decarboxylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64567", "l": "8-epi-ilicicolin H <=> ilicicolin H"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.67", "l": "\"Endopeptidase So\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47583", "l": "ganglioside GT3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GT2 (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44999", "l": "(R)-carnitine + acetoacetyl-CoA <=> CoA + O-3-oxobutanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49603", "l": "ATP + CoA + octanedioate <=> AMP + diphosphate + octanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015518", "l": "arabinose:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66303", "l": "an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose <=> an alpha-D-mannosylinositol-1-phosphodihydroceramide + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64467", "l": "L-tyrosyl-[protein] + 2 O2 <=> H(+) + H2O2 + L-topaquinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52374", "l": "17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+) => 17beta-estradiol + 3'-phosphoadenylyl sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12526", "l": "Delta(1)-piperideine-2-carboxylate + H(+) + NADPH => L-pipecolate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54373", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-(2S,3R,9R)-pristinol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52466", "l": "17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP => 17beta-estradiol + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48656", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55987", "l": "(R)-mandelonitrile + UDP-alpha-D-glucose <=> (R)-prunasin + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047668", "l": "amygdalin beta-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62241", "l": "a thymidine(6-4)cytidine in DNA => a thymine-cytidine dinucleotide in DNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183051", "l": "CBL ubiquitinates Sprouty (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62582", "l": "ADP + D-cystine(in) + H(+) + phosphate => ATP + D-cystine(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879327", "l": "acetylglucosamine-inositol is deacetylated by Mca (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47432", "l": "(7Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371591", "l": "Trimerization of cytosolic HSF1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16701", "l": "17alpha-estradiol + NAD(+) = estrone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34567", "l": "CDP-alpha-D-paratose + NADP(+) = CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH"}, {"i": "EC:1.1.1.342", "l": "\"CDP-paratose synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24547", "l": "H2O + L-lysyl-[protein] + O2 <=> (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12922", "l": "glycine + H(+) + succinyl-CoA => 5-aminolevulinate + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013004", "l": "RHOA binds effectors at the ER membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37151", "l": "(9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate = 1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51706", "l": "4-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + xanthohumol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47778", "l": "2'-O-methylguanosine(1145) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17452", "l": "(2E)-geranyl diphosphate + flaviolin <=> 3-linalylflaviolin + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019135", "l": "deoxyhypusine monooxygenase activity"}, {"i": "RHEA:14101", "l": "[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O"}, {"i": "EC:1.14.99.29", "l": "\"Deoxyhypusine monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38600", "l": "NADP(+) + nicotinate => nicotinamide + nicotinate-adenine dinucleotide phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39226", "l": "(3R)-hydroxyoctacosanoyl-CoA <=> (2E)-octacosenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170159", "l": "Translocation of Cdc25 to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56400", "l": "[(3R)-hydroxybutanoate](n) + H2O = (3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15168", "l": "H2O + O2 + sarcosine <=> glyoxylate + H2O2 + methylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948524", "l": "PTENP1 mRNA binds miR-19b RISC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166220", "l": "FA anion diffuses laterally to UCP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865320", "l": "CBFB binds RUNX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043739", "l": "G/U mismatch-specific uracil-DNA glycosylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388830", "l": "PI3K binds ICOS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950518", "l": "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41428", "l": "L-tyrosine + S-adenosyl-L-methionine = 3-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.304", "l": "\"L-tyrosine C(3)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33796", "l": "H2O + sucrose => alpha-D-glucose + beta-D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692437", "l": "ANG binds F-actin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19060", "l": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione <=> a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62396", "l": "(1S,2S)-pseudoephedrine + NAD(+) = (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183126", "l": "Factor B binds to surface-associated C3b (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35356", "l": "3-hydroxyisopentadecanoyl-CoA => (2E)-13-methyltetradecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25311", "l": "glycolate + O2 = glyoxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48869", "l": "H2O + NADH => AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043743", "l": "LPPG:FO 2-phospho-L-lactate transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55296", "l": "13-cis-retinol + hexadecanoyl-CoA = 13-cis-retinyl hexadecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15868", "l": "AH2 + O2 + tryptamine <=> 4-hydroxytryptamine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17968", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + H(+) <=> (8Z,11Z,14Z)-heptadecatrienal + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52828", "l": "(1S,4R)-isodihydrocarvone + H(+) + NADPH + O2 = (3S,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169901", "l": "Rap1-GTP complex binds BRAF complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31093", "l": "3-oxotetradecanoyl-CoA + CoA => acetyl-CoA + dodecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13478", "l": "H2O + L-tryptophan + NADP(+) => H(+) + indole-3-pyruvate + NADPH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73718", "l": "UBF-1 Binds rDNA Promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-500717", "l": "Activation of GRIK3 homomer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52890", "l": "H(+) + NADPH + nitrosobenzene => N-phenylhydroxylamine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033238", "l": "PEX5L:PEX7:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22785", "l": "(2R)-O-phospho-3-sulfolactate => H(+) + phosphoenolpyruvate + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17430", "l": "NAD(+) + trans-4-hydroxycyclohexanecarboxylate => 4-oxocyclohexanecarboxylate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49293", "l": "D-cellobiose(out) + N(pros)-phospho-L-histidyl-[protein] => 6-phospho-beta-D-glucosyl-(1->4)-D-glucose(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701488", "l": "Active ALK phosphorylates JAK3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25500", "l": "(2E)-geranyl diphosphate = diphosphate + terpinolene"}, {"i": "EC:4.2.3.113", "l": "\"Terpinolene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9671145", "l": "DKC1 binds SHQ1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60967", "l": "(9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + UDP-alpha-D-glucose <=> (9Z)-17-hydroxyoctadec-9-enoate 17-O-sophoroside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2514865", "l": "cGMP dissociates from CNG channels (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869566", "l": "The MYBL2 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36529", "l": "(13Z)-3-oxodocosenoyl-CoA + CO2 + CoA => (11Z)-eicosenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35818", "l": "4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) <=> 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62320", "l": "(+)-premalbrancheamide + chloride + FAD + 2 H(+) = (+)-isomalbrancheamide B + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46445", "l": "(11Z)-hexadecenoyl-CoA + AH2 + O2 => (10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39593", "l": "(2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H2O => (3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875183", "l": "CBL monoubiquitinates activated MET (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20059", "l": "CO2 + NH4(+) + sarcosine => 2 H(+) + H2O + N-carbamoylsarcosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28963", "l": "H(+)(out) + L-proline(out) = H(+)(in) + L-proline(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34978", "l": "(R)-pantothenate(in) <=> (R)-pantothenate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21422", "l": "15-dehydro-prostaglandin I2 + H(+) + NADPH => NADP(+) + prostaglandin I2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3132753", "l": "Pancreatic proteases degrade TCN1:Cbl (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669240", "l": "FLNA binds PAK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004516", "l": "nicotinate phosphoribosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2201293", "l": "Endocytosis of TLR4:LY96:LPS:CD14 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77081", "l": "Formation of the CE:GMP intermediate complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189439", "l": "ALAD condenses 2 dALAs to form PBG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036426", "l": "ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047130", "l": "saccharopine dehydrogenase (NADP+, L-lysine-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46466", "l": "(24S,25)-epoxy-7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24S)-25-epoxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.49"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57753", "l": "2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH => C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20353", "l": "A + chloride + H(+) + trichloroethene = AH2 + tetrachloroethene"}, {"i": "EC:1.21.99.5", "l": "\"Tetrachloroethene reductive dehalogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660822", "l": "ATP binds P2RX4,7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24403", "l": "ATP + UMP <=> ADP + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63001", "l": "(11Z,14Z,17Z)-eicosatrienamide + H2O => (11Z,14Z,17Z)-eicosatrienoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952419", "l": "SMURFs ubiquitinate RUNX3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797090", "l": "CCNK binds CDK12 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16602", "l": "L-aspartate => fumarate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2316347", "l": "RAB4A:GTP binds KIF3 and activates KIF3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1006169", "l": "Factor H binds host cell surface markers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685345", "l": "Formation of isoAsp (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52803", "l": "acetoacetyl-CoA + ATP + L-isoleucine <=> AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013631", "l": "NICD3 binds RBPJ and MAML in the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022911", "l": "CSPG is secreted (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66833", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + preasperterpenoid A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35510", "l": "30-hydroxy-11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> glycyrrhetaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696605", "l": "USP12, USP26 deubiquitinate AR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64999", "l": "ATP + H(+) + octanoate <=> diphosphate + octanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13287", "l": "ADP + H(+) + L-gamma-glutamyl-L-cysteine + phosphate => ATP + L-cysteine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4570493", "l": "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637766", "l": "Binding of SHC1 to p-5Y-EGFRvIII (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209925", "l": "DIT and MIT combine to form triiodothyronine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019786", "l": "Atg8-specific protease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11093", "l": "NAD(+) + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39592", "l": "(3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA => (2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51512", "l": "H2O + oxamate = NH4(+) + oxalate"}, {"i": "EC:3.5.1.126", "l": "\"Oxamate amidohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25098", "l": "ATP + UDP = ADP + UTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49895", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2 <=> (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-532678", "l": "Trimming of the first glucose by by mannosyl-oligosaccharide glucosidase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26250", "l": "H(+) + levopimaradienol + NADPH + O2 => 2 H2O + levopimaradienal + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49597", "l": "an N-acylsphing-4-enine + UDP-alpha-D-galactose => H(+) + N-acyl-D-galactosylsphing-4-enine + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56731", "l": "4-hydroxy-all-trans-beta-carotene + AH2 + O2 <=> 4,4-dihydroxy-all-trans-beta-carotene + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74734", "l": "Re-integration of insulin receptor into plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43887", "l": "3-oxochol-4-en-22-oyl-CoA + NAD(+) <=> 3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37209", "l": "1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44565", "l": "4-hydroxybenzoate + all-trans-decaprenyl diphosphate => 4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198513", "l": "Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046175", "l": "Further sulfation on galactose residues produces KSPG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59595", "l": "ATP + beta-alanine + L-arginine <=> ADP + beta-alanyl-L-arginine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59771", "l": "hexadecanoyl-CoA + L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] <=> CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950364", "l": "IL23R in IL23:IL23 receptor complex is phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44797", "l": "2-demethylmenaquinol-13 + S-adenosyl-L-methionine => H(+) + menaquinol-13 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662706", "l": "Dopachrome transforms to DHI (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000401", "l": "open form four-way junction DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373015", "l": "citrate <=> isocitrate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24932", "l": "H2O + L-cysteine => H(+) + hydrogen sulfide + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168848", "l": "tBID binds to inactive BAK protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66723", "l": "ATP + H2O + N-[(S)-lactoyl]-L-phenylalanine(in) <=> ADP + H(+) + N-[(S)-lactoyl]-L-phenylalanine(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23877", "l": "protoaphin aglucone => H2O + xanthoaphin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63368", "l": "ATP + H2O + spermine(out) = ADP + H(+) + phosphate + spermine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34292", "l": "2',4,4',6'-tetrahydroxychalcone + UDP-alpha-D-glucose => 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28181", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate <=> colnelenate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22977", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811508", "l": "ING2-bound EP300 acetylates TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004077", "l": "biotin-[acetyl-CoA-carboxylase] ligase activity"}, {"i": "RHEA:11756", "l": "ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]"}, {"i": "EC:6.3.4.15", "l": "\"Biotin--[biotin carboxyl-carrier protein] ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15546", "l": "(3S)-citramalate => acetate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48468", "l": "ganglioside GM1b (d18:1(4E)) + H2O = ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28230", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = (+)-costunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.150", "l": "\"Costunolide synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090488", "l": "polo box domain specific binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21283", "l": "H2O + 2 O2 + thiamine <=> H(+) + 2 H2O2 + thiamine acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654623", "l": "Activated FGFR3 binds FRS3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17252", "l": "2 Fe(2+) + 2 H2O + H2O2 <=> 6 H(+) + 2 iron(III) oxide-hydroxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18513", "l": "D-mannitol + O2 = D-mannose + H2O2"}, {"i": "EC:1.1.3.40", "l": "\"D-mannitol oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811431", "l": "RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.21", "l": "\"DNA-3-methyladenine glycosylase II\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097265", "l": "5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity"}, {"i": "REACT:R-HSA-2161776", "l": "5S-HETE is oxidised to 5-oxoETE by 5-HEDH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607756", "l": "TRAF6 oligomer autoubiquitinates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043334", "l": "2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029270", "l": "Recruitment of PLCgamma to membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785594", "l": "FANCD2 binds FANCI (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034896", "l": "3-formiminopyruvate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61055", "l": "(-)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696266", "l": "RND2 binds effectors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416320", "l": "Trafficking of GluR1-containing  AMPA receptors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39271", "l": "(3R)-hydroxy-(15Z)-tetracosenoyl-CoA = (2E,15Z)-tetracosadienoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54668", "l": "pre-alpha-onocerin = alpha-onocerin"}, {"i": "EC:5.4.99.66", "l": "\"Alpha-onocerin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29996", "l": "ATP + H2O + putrescine(out) => ADP + H(+) + phosphate + putrescine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444691", "l": "Prokineticin receptors bind prokineticin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64585", "l": "2-hydroxyethane-1-sulfonate(out) + Na(+)(out) => 2-hydroxyethane-1-sulfonate(in) + Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810234", "l": "General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134800", "l": "STING dimerization (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68914", "l": "DNA polymerase alpha:primase binds at the origin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2059926", "l": "NPHP4 protein binds LATS proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627106", "l": "SMAC (DIABLO) forms dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098615", "l": "dimethyl selenide methyltransferase activity"}, {"i": "REACT:R-HSA-2408554", "l": "Me2Se is methylated to Me3Se+ by INMT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34977", "l": "(R)-pantothenate(out) => (R)-pantothenate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9713785", "l": "Anti-cancer drugs generate DNA interstrand crosslinks (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56690", "l": "(2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate => (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51422", "l": "an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH => a (2S,3S)-flavan-3-ol + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76426", "l": "N-atom dealkylation of caffeine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011748", "l": "IL9R binds JAK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10658", "l": "creatine + H(+) + S-adenosyl-L-homocysteine => guanidinoacetate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950423", "l": "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676595", "l": "TRAFs bind RANK:RANKL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48296", "l": "H2O + prostaglandin E2 1-glyceryl ester = glycerol + H(+) + prostaglandin E2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44573", "l": "4-hydroxy-3-all-trans-heptaprenylbenzoate + H(+) => 2-all-trans-heptaprenylphenol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392295", "l": "Gbeta:gamma recruits PI3K gamma (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010396", "l": "SLIT1 binds COL4A5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55456", "l": "ferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + sugiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30131", "l": "H2O + octanoyl-[ACP] = H(+) + holo-[ACP] + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11997", "l": "biphenyl-2-ol + H(+) + NADH + O2 => biphenyl-2,3-diol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56615", "l": "L-cysteinyl-[protein] + NAD(+) <=> H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51450", "l": "alpha-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59222", "l": "(2Z)-2-hydroxypenta-2,4-dienoate + acetate + H(+) => (2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710490", "l": "The GSDME gene promoter is hypermethylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73800", "l": "SAICAR => AICAR + Fumarate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43194", "l": "2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + H(+) + S-adenosyl-L-homocysteine => cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220816", "l": "NOTCH2 binds CNTN1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798528", "l": "S100A8:S100A9 binds Mn2+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39333", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+) => (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031864", "l": "EP1 subtype prostaglandin E2 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14434", "l": "a tRNA precursor + ATP + 2 CTP => a tRNA with a 3' CCA end + 3 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9667914", "l": "ALK binds ligand midkine (MDK) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617179", "l": "PRKACA phosphorylates TNNI3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693751", "l": "FAAH2 hydrolyses AEA to AA and ETA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17122", "l": "carbamoyl phosphate + L-lysine => H(+) + L-homocitrulline + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004783", "l": "sulfite reductase (NADPH) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607002", "l": "Activated protein C cleaves factor VIIIa (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56436", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428231", "l": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41596", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H(+) + NADH = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876484", "l": "NPC2 transfers CHOL to NPC1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37851", "l": "13-deoxydaunorubicin + H(+) + NADPH + O2 = 13-dihydrodaunorubicin + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-68960", "l": "DNA polymerase epsilon binds at the origin (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48500", "l": "H2O + octanoylglycerol = glycerol + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8864577", "l": "TFAP2C translocates to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.16", "l": "\"Steroid 21-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909552", "l": "Phosphorylation of STAT1 at Ser727 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047558", "l": "3-cyanoalanine hydratase activity"}, {"i": "RHEA:15385", "l": "L-asparagine = 3-cyano-L-alanine + H2O"}, {"i": "EC:4.2.1.65", "l": "\"3-cyanoalanine hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55944", "l": "2-chloroethanol + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + chloroacetaldehyde + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61239", "l": "H2O + L-methionine + O2 <=> 4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46998", "l": "6-hydroxypseudooxynicotine => 6-hydroxy-N-methylmyosmine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665408", "l": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018457", "l": "perillyl-alcohol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047053", "l": "(S)-cheilanthifoline synthase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043237", "l": "laminin-1 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15835", "l": "4-hydroxybenzaldehyde + CO2 + H2O2 => (S)-4-hydroxymandelate + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014293", "l": "RAC2 GDIs block activation of RAC2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983696", "l": "The Immunoglobulin of the BCR binds antigen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029690", "l": "Caspase-6 translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54974", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + holo-[ACP] => 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53379", "l": "5,6-dihydrouridine(16) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(16) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42968", "l": "cytidine(56) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.206", "l": "\"tRNA (cytidine(56)-2'-O)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14640", "l": "3'-phosphoadenylyl sulfate + a thiol <=> adenosine 3',5'-bisphosphate + H(+) + S-alkyl thiosulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50771", "l": "4-methylamino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine <=> anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31196", "l": "(3S)-hydroxyoctanoyl-CoA + NAD(+) => 3-oxooctanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432148", "l": "Fgr may phosphorylate p38 MAPK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6802973", "l": "PLK3 phosphorylates CDC25C (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2428922", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60184", "l": "ATP + D-glucose(out) + H2O = ADP + D-glucose(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24908", "l": "(E)-4-coumarate + NH4(+) => L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21584", "l": "NAD(+) + propane-1,2-diol 1-phosphate = H(+) + hydroxyacetone phosphate + NADH"}, {"i": "EC:1.1.1.7", "l": "\"Propanediol-phosphate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10411", "l": "4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA <=> 3-oxopristanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168459", "l": "Lyn activates ERK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031727", "l": "CCR2 chemokine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66532", "l": "ATP + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] = diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43904", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol = all-trans-retinyl hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098680", "l": "template-free RNA nucleotidyltransferase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33764", "l": "a (2E)-enoyl-CoA + H(+) + NADPH => a 2,3-saturated acyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809785", "l": "MTMR2 dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37116", "l": "sphing-4-enine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389941", "l": "SHP-1 and SHP-2 bind pBTLA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29121", "l": "a ubiquinone + H2O + nitrite => a ubiquinol + nitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40836", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2 H2O => 2 (9Z)-octadecenoate + 2 H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27776", "l": "6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49206", "l": "20S,24R-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63498", "l": "4-nitrobenzyl alcohol + NADP(+) => 4-nitrobenzaldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31516", "l": "4'-apo-beta-carotenal + H2O + NAD(+) => 2 H(+) + NADH + neurosporaxanthin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210805", "l": "Removal of miRNA passenger strand (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350444", "l": "ROK phosphorylates SQH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-879594", "l": "SLCO4C1 mediates the transport of digoxin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43246", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451895", "l": "IL2RG binds JAK3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51935", "l": "2 [Fe(III)-cytochrome c3] + hydrogen sulfide + sulfite <=> 2 [Fe(II)-cytochrome c3] + thiosulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102093", "l": "acrylate:acyl-coA CoA transferase activity"}, {"i": "MetaCyc:RXN-10985"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68610", "l": "Formation of ORC(2-5) complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004492", "l": "methylmalonyl-CoA decarboxylase activity"}, {"i": "RHEA:21396", "l": "(S)-methylmalonyl-CoA + H(+)(out) + Na(+)(in) = CO2 + Na(+)(out) + propanoyl-CoA"}, {"i": "EC:7.2.4.3", "l": "\"(S)-methylmalonyl-CoA decarboxylase (sodium-transporting)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167047", "l": "pro-beta-NGF dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14810", "l": "phenol + S-adenosyl-L-methionine => anisole + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42772", "l": "guanosine(1405) in 16S rRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(1405) in 16S rRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.179", "l": "\"16S rRNA (guanine(1405)-N(7))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23182", "l": "a ketone + H2O2 => a secondary alcohol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37618", "l": "(9Z)-octadecenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165162", "l": "Phosphorylation of TSC2 by PKB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-741411", "l": "CYLD deubiquitinates NEMO (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20788", "l": "NAD(+) + phosphate = ADP-D-ribose 1''-phosphate + H(+) + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70592", "l": "PXLP-K259-GOT1 dimer deaminates L-Asp (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944254", "l": "Association of procollagen type XXVI (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30735", "l": "1D-myo-inositol 4-phosphate + H2O = myo-inositol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022911", "l": "CSPG is secreted (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183051", "l": "CBL ubiquitinates Sprouty (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080002", "l": "UDP-glucose:4-aminobenzoate acylglucosyltransferase activity"}, {"i": "MetaCyc:RXN-6142"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11375", "l": "ATP + L-aspartate + NH4(+) <=> AMP + diphosphate + H(+) + L-asparagine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11359", "l": "A + H(+) + NADH <=> AH2 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102178", "l": "4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol-methyl oxidase activity"}, {"i": "RHEA:58880", "l": "4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 = 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}, {"i": "MetaCyc:RXN-11932"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21853", "l": "(R)-10-hydroxyoctadecanoate => (9Z)-octadecenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49914", "l": "(R)-carnitine(in) + O-propanoyl-(R)-carnitine(out) => (R)-carnitine(out) + O-propanoyl-(R)-carnitine(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "78.423603998002051", "identifiers": [{"i": "GO:0016713", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15234", "l": "[Fe(III)cytochrome c] + H2O + nitric oxide => [Fe(II)cytochrome c] + 2 H(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805126", "l": "AURKB phosphorylates TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799097", "l": "ATM phosphorylates ZNF420 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61148", "l": "myricetin 3-O-alpha-L-rhamnoside + UDP-alpha-D-glucose = H(+) + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419843", "l": "CALCA(83-119) binds CALCR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419334", "l": "Melatonin receptors can bind melatonin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65518", "l": "NH4(+) + pre-mycofactocin => 5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186765", "l": "PLC-gamma binds to the active receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102628", "l": "costunolide 3beta-hydroxylase activity"}, {"i": "MetaCyc:RXN-15533"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47934", "l": "(R)-3-sulfolactate + 2 H(+) + NADH => (S)-3-sulfolactaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033999", "l": "chondroitin B lyase activity"}, {"i": "MetaCyc:4.2.2.19-RXN"}, {"i": "EC:4.2.2.19", "l": "\"Chondroitin B lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59718", "l": "D-maltopentaonate + H(+) => D-maltopentaono-1,5-lactone + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004140", "l": "dephospho-CoA kinase activity"}, {"i": "RHEA:18245", "l": "3'-dephospho-CoA + ATP = ADP + CoA + H(+)"}, {"i": "EC:2.7.1.24", "l": "\"Dephospho-CoA kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9611851", "l": "ADRB2 bind ADR,NAd (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109862", "l": "MAP2K2 phosphorylates MAPK1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617828", "l": "TRIP11:IFT20 dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54722", "l": "H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40515", "l": "6-deoxy-6-sulfo-D-fructose 1-phosphate = 3-sulfolactaldehyde + dihydroxyacetone phosphate"}, {"i": "EC:4.1.2.57", "l": "\"Sulfofructosephosphate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36581", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH => dTDP-alpha-D-fucose + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48533", "l": "ganglioside GQ1c (d18:1(4E)) + H2O => ganglioside GT1c (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8863494", "l": "ASICs bind STOML3, (STOM) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004693", "l": "cyclin-dependent protein serine/threonine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48322", "l": "ganglioside Fuc-GA1 + GDP + H(+) => ganglioside GA1 + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801195", "l": "STEAP3 binds BNIP3L (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33672", "l": "2 [Fe(III)-cytochrome b5] + an N-(2,3-dihydroxyhexacosanoyl)-(4R)-hydroxysphinganine + H2O => 2 [Fe(II)-cytochrome b5] + 2 H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31283", "l": "FAD + H(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54111", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + guaia-4,6-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64795", "l": "L-lysine + NADP(+) <=> 2 H(+) + L-1-piperideine-6-carboxylate + NADPH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849463", "l": "PTK6 phosphorylates SFPQ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24446", "l": "GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[(1->4)-alpha-L-Fuc]-beta-D-GlcNAc}-L-asparaginyl-[protein] => GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62114", "l": "H2O + iminosuccinate => (3S)-3-hydroxy-D-aspartate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043274", "l": "phospholipase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63875", "l": "2-oxoglutarate + L-isoleucine + O2 <=> 3(1)-hydroxy-L-isoleucine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653974", "l": "Ragulator binds Rag dimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33793", "l": "beta-D-fructose + beta-D-glucose 6-phosphate => H2O + sucrose 6(F)-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14433", "l": "a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate"}, {"i": "EC:2.7.7.72", "l": "\"CCA tRNA nucleotidyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948034", "l": "FGR binds LDL:LRP8 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24317", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (+)-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23254", "l": "[thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate => [thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33938", "l": "2 N(omega)-hydroxy-L-arginine + NADH + 2 O2 <=> H(+) + 2 H2O + 2 L-citrulline + NAD(+) + 2 nitric oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49881", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15753", "l": "GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate"}, {"i": "EC:6.3.4.4", "l": "\"Adenylosuccinate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42469", "l": "2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O => 2-oxopent-4-enoate + salicylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54935", "l": "(3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] <=> (2E,9Z)-hexadecadienoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948775", "l": "MKRN1 polyubiquitinates PTEN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17605", "l": "ATP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine = ADP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H(+) + phosphate"}, {"i": "EC:6.3.2.25", "l": "\"Tubulin--tyrosine ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32575", "l": "(2E)-geranyl diphosphate = (1R,5R)-alpha-pinene + diphosphate"}, {"i": "EC:4.2.3.121", "l": "\"(+)-alpha-pinene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9671145", "l": "DKC1 binds SHQ1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55562", "l": "a hydroxy-epoxy-eicosatetraenoate => a hydroperoxyeicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211968", "l": "CYP2W1 oxidises INDOL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27992", "l": "1-deoxy-D-xylulose 5-phosphate + ADP + H(+) => 1-deoxy-D-xylulose + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636261", "l": "NOS2 gene produces NOS2 protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15007", "l": "CO2 + gibberellin A8 + succinate => 2-oxoglutarate + gibberellin A1 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50797", "l": "glutathione + prostaglandin A2 => prostaglandin A2-S-(R)-glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649726", "l": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42345", "l": "H(+) + NADH + O2 + p-cumate => (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794347", "l": "Homer1,2,3 dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41692", "l": "1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61142", "l": "CO2 + H(+) + H2O + myricetin + succinate => (2R,3R)-dihydromyricetin + 2-oxoglutarate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59636", "l": "D-xylotriose + O2 = D-xylotriono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47017", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 2 A + 3 H2O => [DsrC protein]-dithiol + 2 AH2 + 2 H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-376851", "l": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848124", "l": "PTK6 phosphorylates STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018792", "l": "bis(4-chlorophenyl)acetate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71164", "l": "homogentisate + O2 => maleylacetoacetate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44040", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = 14,15-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18213", "l": "alpha-D-glucose 1-phosphate + CTP + H(+) = CDP-D-glucose + diphosphate"}, {"i": "EC:2.7.7.33", "l": "\"Glucose-1-phosphate cytidylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.n2", "l": "\"Blood group B linear chain alpha-1,3-galactosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72139", "l": "Formation of the active Spliceosomal C (B*) complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14985", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}, {"i": "EC:1.13.11.40", "l": "\"Arachidonate 8-lipoxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418456", "l": "cGMP is degraded by PDEs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65311", "l": "an ultra-long-chain di-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] <=> a 3-oxo-ultra-long-chain di-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110319", "l": "Elongation by POLH (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13150", "l": "A + H(+) + NADPH => AH2 + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53322", "l": "alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+) => alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38686", "l": "ATP + H2O + sphing-4-enine(in) <=> ADP + H(+) + phosphate + sphing-4-enine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49539", "l": "2-amino-2-deoxy-D-gluconate <=> (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932351", "l": "KEAP1 facilitates ubiquitination of NFE2L2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940134", "l": "FOLR2 binds FOLA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65041", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + a tri-(9Z,12Z-octadecadienoyl)-monolysocardiolipin => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50816", "l": "androst-4-ene-3,17-dione + H(+) + NADPH = 5alpha-androstan-3,17-dione + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395412", "l": "Phosphorylation of SYK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32193", "l": "2-oxoglutarate + 2 H(+) + NH4(+) + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42019", "l": "cortisone + NAD(+) <=> 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70241", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16996", "l": "6 [Fe(III)cytochrome c] + 3 H2O + S-disulfanyl-L-cysteinyl-[SoxY protein] <=> 6 [Fe(II)cytochrome c] + 7 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40107", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55303", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18367", "l": "CO2 + NADH + pyruvate => (R)-malate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168324", "l": "Conformation change in hemagglutinin freeing the fusion peptide of HA2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694605", "l": "nsp12 synthesizes minus strand SARS-CoV-2 genomic RNA complement (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023345", "l": "NOTCH1 gene expression is inhibited by MECP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55275", "l": "11-cis-retinol + tetradecanoyl-CoA <=> 11-cis-retinyl tetradecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9611852", "l": "ADRB3 bind ADR,NAd (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18486", "l": "6-acetyl-D-glucose + H2O => acetate + D-glucose + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047957", "l": "4'-methoxyisoflavone 2'-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34600", "l": "15-methylhexadecasphinganine + NADP(+) => 3-dehydro-15-methylhexadecasphinganine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39127", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+) = 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046405", "l": "glycerol dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23889", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine => [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66892", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109857", "l": "MAP2K1 binds MAPK3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43725", "l": "(2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3790130", "l": "Regulation of IL6 transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.41", "l": "\"Polypeptide N-acetylgalactosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43414", "l": "an N-acyl-sphingoid base + D-galactose => a D-galactosylceramide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-741411", "l": "CYLD deubiquitinates NEMO (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58766", "l": "1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphate + NADP(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64628", "l": "acetyl-CoA + octan-1-ol = CoA + octyl acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48444", "l": "H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol = a fatty acid + H(+) + long chain 2-acyl-3-O-beta-D-galactosyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17859", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taurohyocholate => O2 + reduced [NADPH--hemoprotein reductase] + taurochenodeoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13324", "l": "(R)-3,3-dimethylmalate + NAD(+) <=> 3-methyl-2-oxobutanoate + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64752", "l": "3-sulfanylpentan-1-ol-L-cysteine + H2O = 3-sulfanyl-1-pentanol + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050593", "l": "N-methylcoclaurine 3'-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11937", "l": "4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA => 4 CO2 + 4 CoA + trans-resveratrol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37275", "l": "H2O + L-alanyl-L-glutamine = L-alanine + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48987", "l": "(2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2 <=> 2,4-dichlorophenol + CO2 + glyoxylate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34697", "l": "Delta(6)-protoilludene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46460", "l": "22R-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22R,7alpha)-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8980691", "l": "RHOA GEFs activate RHOA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603275", "l": "Defective TBXAS1 does not isomerise PGH2 to TXA2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27901", "l": "3'-AMP + H2O <=> adenosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400143", "l": "Fatty acid ligands activate PPARA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678920", "l": "TLR processing at low pH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42533", "l": "uridine(55) in tRNA => pseudouridine(55) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66887", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 11-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013023", "l": "RHOB GEFs activate RHOB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44211", "l": "12-methyltridecanoate + ATP + CoA <=> 12-methyltridecanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204779", "l": "Interaction of Tie2 with Ang1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.41"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008694", "l": "IL37, IL37(?-218) translocates from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52486", "l": "(3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + AH2 => (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158278", "l": "factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61358", "l": "ADP + H(+) + methotrexate(out) + phosphate => ATP + H2O + methotrexate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392195", "l": "Gi activation by P2Y purinoceptor 12 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65232", "l": "3-hydroxydodecanoyl-CoA + H2O = 3-hydroxydodecanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2029471", "l": "Hydrolysis of PC to PA by PLD (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47673", "l": "H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+) => 2''-O-malonyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034819", "l": "3-HSA hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31702", "l": "4 H(+) + 2 O2 + pentalenene + 4 reduced [2Fe-2S]-[ferredoxin] <=> 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10364", "l": "2-oxoglutarate + dodecanoyl-CoA + H2O = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+)"}, {"i": "EC:2.3.3.4", "l": "\"Decylhomocitrate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623643", "l": "RDH13 reduces atRAL to atROL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51656", "l": "keto-D-tagaturonate = keto-D-fructuronate"}, {"i": "EC:5.1.2.7", "l": "\"Tagaturonate epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3223200", "l": "Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51303", "l": "(9Z)-octadecenoate + L-phenylalanine <=> H2O + N-(9Z-octadecenoyl)-L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052724", "l": "inositol hexakisphosphate 3-kinase activity"}, {"i": "MetaCyc:RXN-10971"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029460", "l": "PAK1 phosphorylates LIMK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017161", "l": "inositol-1,3,4-trisphosphate 4-phosphatase activity"}, {"i": "REACT:R-HSA-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Homo sapiens)"}, {"i": "RHEA:43392", "l": "1D-myo-inositol 1,3,4-trisphosphate + H2O = 1D-myo-inositol 1,3-bisphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52101", "l": "5-(9Z-octadecenoyloxy)-octadecanoate + H2O => (9Z)-octadecenoate + 5-hydroxy-octadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9005980", "l": "IL21 binds IL21R:JAK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14853", "l": "4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl-CoA + chloride + H(+)"}, {"i": "EC:3.8.1.7", "l": "\"4-chlorobenzoyl-CoA dehalogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030740", "l": "inositol 3-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047938", "l": "glucose-6-phosphate 1-epimerase activity"}, {"i": "MetaCyc:GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22931", "l": "4-acetamidobutanoyl-CoA + H2O <=> 4-aminobutanoyl-CoA + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71590", "l": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418868", "l": "Recruitment of Src and Fyn to DCC:FADK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0036137", "l": "kynurenine aminotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17114", "l": "H2O + L-serine-phosphoethanolamine => H(+) + L-serine + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65520", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-3-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170674", "l": "Dissociation of the Gi alpha:G olf complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655339", "l": "Activated FGFR2 mutants bind FRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-169895", "l": "Crk's SH3 domain engages C3G (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2464822", "l": "RDH12 reduces atRAL to atROL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22361", "l": "D-glutamate => 5-oxo-D-proline + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052723", "l": "inositol hexakisphosphate 1-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139920", "l": "Translocation of tBID to mitochondria (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14157", "l": "H2O + triphosphate = diphosphate + phosphate"}, {"i": "EC:3.6.1.25", "l": "\"Triphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797293", "l": "Expression of IL18, ALOX5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28692", "l": "(S)-dihydroorotate + a ubiquinone => a ubiquinol + orotate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665389", "l": "Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13548", "l": "(6E,10E)-geranyllinalool + O2 + reduced [NADPH--hemoprotein reductase] <=> (3E,7E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097004", "l": "adipokinetic hormone binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002950", "l": "ceramide phosphoethanolamine synthase activity"}, {"i": "REACT:R-HSA-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1297333", "l": "Association of Acrosin Heavy and Light Chain (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55147", "l": "[(3S,4R)-4-(6-methylheptanoyl)-5-oxooxolan-3-yl]methyl phosphate + NADP(+) <=> [4-(6-methylheptanoyl)-5-oxo-2H-furan-3-yl]methyl phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55045", "l": "(3E,5Z)-tetradecadienoyl-CoA + H2O => (3E,5Z)-tetradecadienoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37092", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(10Z,13Z,16Z)-docosatrienoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111238", "l": "Formation of ADAR2  homodimer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46036", "l": "2'-deoxycytidine + UTP = dCMP + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011748", "l": "IL9R binds JAK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58953", "l": "(20S)-protopanaxatriol + UDP-alpha-D-glucose => (20S)-ginsenoside Rh1 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0106345", "l": "glyoxylate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11567", "l": "4-O-beta-D-glucopyranosyl-D-gluconate + phosphate <=> alpha-D-glucose 1-phosphate + D-gluconate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008455", "l": "alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity"}, {"i": "REACT:R-HSA-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40394", "l": "1-O-alkyl-2-acyl-sn-glycerol + an acyl-CoA <=> 1-O-alkyl-2,3-diacyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48462", "l": "2-octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + octanoate => 1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58968", "l": "1-naphthaldehyde + H2O + O2 = 1-naphthoate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16510", "l": "H(+) + oxalate => CO2 + formate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15493", "l": "A + H2O + N2 = AH2 + nitrous oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450488", "l": "BRF1 Complex recruits RNA degradation activities (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202137", "l": "AKT1 binds eNOS complex via HSP90 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48447", "l": "H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol <=> a fatty acid + H(+) + long chain 2-acyl-3-O-beta-D-galactosyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13627", "l": "3-methyl-2-butenal + adenine + AH2 => A + H2O + N(6)-dimethylallyladenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375302", "l": "Kinetochore capture of astral microtubules (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57332", "l": "H2O + 3 O2 + 3 propionate 3-nitronate = 3 3-oxopropanoate + 3 H(+) + H2O2 + 2 nitrate + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27583", "l": "2-(hydroxymethyl)glutarate => 2-methyleneglutarate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19720", "l": "H(+) + L-phenylalanine <=> 2-phenylethylamine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782138", "l": "ERCC5 and RPA bind TC-NER site (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14752", "l": "1-hydroxy-2-naphthoate + O2 <=> (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63487", "l": "2-oxoglutarate + L-prolyl-[protein] + O2 <=> CO2 + succinate + trans-4-hydroxy-L-prolyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047238", "l": "glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"}, {"i": "REACT:R-HSA-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17439", "l": "(2E,4E)-2,4-dichloromuconate + H(+) => 2,4-dichloro-5-oxo-2,5-dihydro-2-furylacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38382", "l": "(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+) <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0015035", "l": "protein-disulfide reductase activity"}, {"i": "MetaCyc:DISULFOXRED-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20802", "l": "3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941895", "l": "Formation of CDK4/6:CCND complexes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27573", "l": "ATP + D-glycero-alpha-D-manno-heptose 7-phosphate <=> ADP + D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n13"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0015489", "l": "putrescine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380586", "l": "loading of Serotonin in synaptic vesicles (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015151", "l": "alpha-glucoside transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21022", "l": "chorismate + phosphate => 5-O-(1-carboxyvinyl)-3-phosphoshikimate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352945", "l": "fructose 6-phosphate + ATP => fructose 1,6-bisphosphate + ADP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41769", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E)) => CMP + ganglioside GT1a (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23064", "l": "an alkanesulfonate + FMNH2 + O2 = an aldehyde + FMN + 2 H(+) + H2O + sulfite"}, {"i": "EC:1.14.14.5", "l": "\"Alkanesulfonate monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656215", "l": "RAF1 mutant complexes phosphorylate MAP2K dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655483", "l": "USP1 autocleavage (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850777", "l": "SPINK6 binds KLK14 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40108", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA => 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008511", "l": "sodium:potassium:chloride symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44883", "l": "ATP + L-threonyl-[receptor-protein] <=> ADP + H(+) + O-phospho-L-threonyl-[receptor-protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54866", "l": "4-methylpent-3-en-1-yl acetate + H2O + NADP(+) => H(+) + NADPH + O2 + sulcatone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14576", "l": "D-glucarate <=> 5-dehydro-4-deoxy-D-glucarate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6795290", "l": "TORC2 complex phosphorylates SGK1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56765", "l": "12-epi-fischerindole U + 2-oxoglutarate + chloride + H(+) + O2 => 12-epi-fischerindole G + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48845", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17258", "l": "O2 + reduced [NADPH--hemoprotein reductase] + vinorine => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + vomilenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671993", "l": "CIT-3 binds DLG4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090448", "l": "glucosinolate:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866941", "l": "MID1IP1 binds THRSP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981892", "l": "Active G alpha (z) binds RGS proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66501", "l": "GDP-alpha-D-rhamnose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33028", "l": "4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spheroidene => 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + spheroiden-2-one"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047422", "l": "N-acyl-D-aspartate deacylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30919", "l": "A + rhodopin = (3E)-3,4-didehydrorhodopin + AH2"}, {"i": "EC:1.3.99.27", "l": "\"1-hydroxycarotenoid 3,4-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26027", "l": "H2O + N(1)-acetylspermidine + O2 = 3-aminopropanal + H2O2 + N-acetylputrescine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050614", "l": "delta24-sterol reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27502", "l": "3',5'-di-O-methyltricetin + S-adenosyl-L-methionine => 3',4',5'-O-trimethyltricetin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694367", "l": "Glycosylated M localizes to the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2089971", "l": "Secretion of collagens (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449976", "l": "IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61480", "l": "a sphingoid base + a very long-chain fatty acyl-CoA = an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+)"}, {"i": "EC:2.3.1.297", "l": "\"Very-long-chain ceramide synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48254", "l": "ganglioside GD1b + H(+) + UDP => ganglioside GD2 + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61624", "l": "2-oxoglutarate + cadaverine = 5-aminopentanal + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000249", "l": "C-22 sterol desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15326", "l": "an acyl-CoA + sn-glycerol 3-phosphate => a 1-acyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043776", "l": "cobalt-precorrin-6B C5-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112392", "l": "Resumption of elongation after recovery from pausing (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-167427", "l": "Opioid dissociates from MOR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46377", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34190", "l": "(2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O <=> (2Z)-2-hydroxypenta-2,4-dienoate + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22475", "l": "(R)-pantetheine + ATP <=> ADP + D-pantetheine 4'-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373741", "l": "SDK2 homophillic interaction (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24988", "l": "(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin] = calcitroate + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009488", "l": "IL34 binds CSF1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617815", "l": "BBSome binds RAB3IP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36461", "l": "glycine + L-proline => glycyl-L-proline + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43898", "l": "3beta,7alpha-dihydroxy-5alpha-androstan-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3beta-hydroxy-5alpha-androstan-17-one + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66864", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + quiannulatene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18363", "l": "3-O-(beta-D-xylosyl)-L-seryl-[protein] + dolichyl phosphate + H(+) => dolichyl D-xylosyl phosphate + L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17244", "l": "an alpha-amino acid ester + H2O <=> an alcohol + an alpha-amino acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20863", "l": "(1S,6R)-isopiperitenol + NAD(+) <=> (6R)-isopiperitenone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18706", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9619355", "l": "CaMKK autophosphorylates in the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18407", "l": "H(+) + NADH + NH4(+) + pyruvate => H2O + L-alanine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49599", "l": "an N-acylsphing-4-enine + UDP-alpha-D-galactose <=> H(+) + N-acyl-D-galactosylsphing-4-enine + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58252", "l": "H2O + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] = ADP-D-ribose + L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698677", "l": "HCMV UL36 binds MLKL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29949", "l": "H(+)(out) + L-rhamnopyranose(out) => H(+)(in) + L-rhamnopyranose(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199203", "l": "PANK1/3/4 phosphorylate PanK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46161", "l": "a quinone + H(+) + NADH => a quinol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863463", "l": "STON2 binds SYT proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60738", "l": "(2E,6E)-farnesoate + 2 H(+) + NADPH => (2E,6E)-farnesal + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428909", "l": "Activated TP receptor binds G-protein  G13 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25153", "l": "2-oxoglutarate + L-phenylalanine => 3-phenylpyruvate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55667", "l": "2 AH2 + echinenone + 2 O2 <=> 2 A + canthaxanthin + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23487", "l": "A + D-cellobiose <=> AH2 + D-cellobiono-1,5-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39937", "l": "(9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44219", "l": "12-hydroxyoctadecanoate + ATP + CoA <=> 12-hydroxyoctadecanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29400", "l": "H2O + ITP => diphosphate + H(+) + IMP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034202", "l": "glycolipid floppase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19600", "l": "H2O + L-arginine <=> L-citrulline + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033944", "l": "beta-galactofuranosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66081", "l": "2-oxopentanoate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminopentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53701", "l": "2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549129", "l": "OCT1 transports organic cations into hepatic cells (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42381", "l": "2 A + all-trans-4,4'-diapolycopene-4,4'-dial + 2 H2O => 2 AH2 + all-trans-4,4'-diapolycopene-4,4'-dioate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22934", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5205649", "l": "p62 links damaged mitochondria to LC3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097372", "l": "NAD-dependent histone deacetylase activity (H3-K18 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265940", "l": "Rad51 assembly at the DNA-damage sites on the chromatin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265456", "l": "NPC1L1 binds ezetimibe (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5651828", "l": "PARG dePARylates PARP1,PARP2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009488", "l": "IL34 binds CSF1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709360", "l": "H2O2 reduces MetHb (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879907", "l": "Tyrosine kinases phosphorylate the receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42888", "l": "(R)-3-phosphomevalonate + ATP = (R)-3,5-bisphosphomevalonate + ADP + H(+)"}, {"i": "EC:2.7.1.186", "l": "\"Mevalonate-3-phosphate 5-kinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0004396", "l": "hexokinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.34"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18879", "l": "1D-3-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine => myo-inositol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11384", "l": "(S)-2-hydroxydecanoate + NAD(+) = 2-oxodecanoate + H(+) + NADH"}, {"i": "EC:1.1.1.99", "l": "\"(S)-2-hydroxy-fatty-acid dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375384", "l": "Bombesin-like receptors bind bombesin homologues (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937814", "l": "RUNX3 translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10434", "l": "acetate + CO2 + NH4(+) + succinate semialdehyde => 2-(acetamidomethylene)succinate + H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62705", "l": "glycyldehydrophenylalanine + H2O => 2,3-didehydrophenylalanine + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029272", "l": "Release of PLCG from FCGR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39096", "l": "(3S)-hydroxydecanedioyl-CoA + NAD(+) => 3-oxodecanedioyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39246", "l": "(11Z)-3-oxoicosenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z)-eicosenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42735", "l": "guanosine(527) in 16S rRNA + S-adenosyl-L-methionine <=> N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-182594", "l": "Association of INK4 family proteins with CDK4/6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042134", "l": "rRNA primary transcript binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909552", "l": "Phosphorylation of STAT1 at Ser727 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36339", "l": "[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine = 2-thio-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5627775", "l": "Autophosphorylation of PAK1,2,3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913360", "l": "GM-CSF receptor alpha subunit binds GM-CSF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2197690", "l": "Detachment of WASP/WAVE (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24083", "l": "ATP + L-tryptophan + tRNA(Trp) <=> AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3139027", "l": "Maturation of HIV Virion (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12275", "l": "H(+) + L-dopa <=> CO2 + dopamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62043", "l": "H2O + N-(octanoyl)-sphing-4-enine-1-phosphate <=> N-octanoylsphing-4-enine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626817", "l": "PKC phosphorylates NCF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11570", "l": "5-methyldeoxycytidine 5'-phosphate + 7,8-dihydrofolate => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071890", "l": "bicarbonate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-350058", "l": "Formation of CSL NCOR corepressor complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48463", "l": "1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O <=> 2-octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30583", "l": "2-demethylmenaquinol-8 + H(+) + trimethylamine N-oxide = 2-demethylmenaquinone-8 + H2O + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24875", "l": "D-serine + phosphate => H2O + O-phospho-D-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847977", "l": "FRK phosphorylates PTEN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20433", "l": "NAD(+) + xylitol = D-xylulose + H(+) + NADH"}, {"i": "EC:1.1.1.9", "l": "\"D-xylulose reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864381", "l": "TFAP2A,TFAP2C homodimers bind ESR1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350869", "l": "Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23059", "l": "urea <=> cyanamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56507", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645535", "l": "ALPK1 phosphorylates TIFA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31472", "l": "beta-D-gentiobiosyl crocetin + UDP-alpha-D-glucose => beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22514", "l": "hydrogenobyrinate => 3 H(+) + precorrin-8X"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31783", "l": "H2O + tuberculosinyl diphosphate = diphosphate + tuberculosinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008700", "l": "4-hydroxy-2-oxoglutarate aldolase activity"}, {"i": "MetaCyc:4OH2OXOGLUTARALDOL-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432121", "l": "LDL binds to LRP8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163625", "l": "Glucagon binds to Glucagon receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51904", "l": "10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate = 10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047515", "l": "1,3-beta-oligoglucan phosphorylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65447", "l": "butanoyl-CoA + hexan-1-ol <=> CoA + hexyl butanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682967", "l": "WHSC1 binds DNA DSBs (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35142", "l": "(E)-4-coumaroyl-CoA + (E)-feruloylacetyl-CoA + H2O <=> CO2 + 2 CoA + demethoxycurcumin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27797", "l": "(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate <=> all-trans-heptaprenyl diphosphate + 4 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351849", "l": "Caspase-mediated cleavage of Etk (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080101", "l": "phosphatidyl-N-dimethylethanolamine N-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928645", "l": "EPHB:NMDAR binds TIAM1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060724", "l": "coreceptor activity involved in epidermal growth factor receptor signaling pathway"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610726", "l": "The IFT-A complex recruits TULP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57733", "l": "A + all-trans-7,8-dihydroretinol => AH2 + all-trans-retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578965", "l": "TNRC6A binds AGO2:miRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013158", "l": "CDC42 GDIs block activation of CDC42 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64695", "l": "isobutanol + NAD(+) <=> 2-methylpropanal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019769", "l": "low-affinity IgE receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65623", "l": "hexadecanoyl-CoA + sphinga-(4E,8E)-dienine <=> CoA + H(+) + N-hexadecanoylsphinga-(4E,8E)-dienine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2430535", "l": "MASTL phosphorylates ENSA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52915", "l": "3-dimethylallyl-4-hydroxymandelate + O2 <=> 3-dimethylallyl-4-hydroxybenzoate + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017057", "l": "6-phosphogluconolactonase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12133", "l": "ATP + Cd(2+)(in) + H2O => ADP + Cd(2+)(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690873", "l": "ACO1 binds 4Fe-4S (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22727", "l": "a sterol + UDP-alpha-D-glucose <=> a sterol 3-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13450", "l": "2-hydroxyglutarate + NAD(+) => 2-oxoglutarate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48799", "l": "O2 + prostaglandin H1 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxyprostaglandin H1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033739", "l": "preQ1 synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53809", "l": "cholestanol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042897", "l": "polymyxin transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1454916", "l": "The ABCC family mediates organic anion transport (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18643", "l": "a menaquinol => a menaquinone + H2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65253", "l": "(2E,6E)-farnesyl diphosphate + 6-hydroxymellein => diphosphate + verruculide C"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035598", "l": "N6-threonylcarbomyladenosine methylthiotransferase activity"}, {"i": "REACT:R-HSA-6786571", "l": "CDKAL1:4Fe-4S methylthiolates N6-threonylcarbamoyladenosine-37 in tRNA yielding 2-methylthio-N6-threonylcarbamoyladenosine-37 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388831", "l": "Phosphorylation of CD28 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10429", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59630", "l": "4-aminobutanoate + L-arginine => H2O + N(2)-(4-aminobutanoyl)-L-arginine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052797", "l": "4-O-methyl-glucuronoyl methylesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373075", "l": "Metabotropic glutamate receptors bind glutamate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18032", "l": "2 ATP + hydrogencarbonate + NH4(+) <=> 2 ADP + carbamoyl phosphate + 2 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11706", "l": "CO2 + N-(aminomethyl)urea => 2 H(+) + N-(carboxyaminomethyl)urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28120", "l": "D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP => di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31878", "l": "(S)-2,3-epoxysqualene <=> marneral"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60062", "l": "alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032216", "l": "glucosaminyl-phosphatidylinositol O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168883", "l": "Binding of NS1 to poly(A)-binding protein II (PABII) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684140", "l": "ATM phosphorylates RBBP8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662466", "l": "XYLB phosphorylates D-xylulose (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19629", "l": "D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH"}, {"i": "EC:1.1.1.42", "l": "\"Isocitrate dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688025", "l": "Defective pro-SFTPB does not translocate from ER membrane to multivesicle body (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141040", "l": "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209924", "l": "Dopa is decarboxylated to dopamine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51807", "l": "deoxyhumulone + dimethylallyl diphosphate <=> diphosphate + H(+) + lupulone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41595", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH <=> 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16194", "l": "an (R)-2-haloacid + H2O => a (2R)-2-hydroxycarboxylate + a halide anion + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50647", "l": "2-(3-methylsulfanyl)propylmalate <=> 3-(3-methylsulfanyl)propylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634402", "l": "Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 homodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58993", "l": "(E)-cinnamaldehyde + H2O + O2 => (E)-cinnamate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34070", "l": "5-phospho-alpha-D-ribose 1-diphosphate + H(+) + trans,octa-cis-decaprenyl phosphate <=> diphosphate + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41450", "l": "(4S)-4-hydroxy-L-isoleucine + CO2 + succinate => 2-oxoglutarate + L-isoleucine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420883", "l": "Opsins act as GEFs for G alpha-t (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20253", "l": "(2R,3S)-2,3-dimethylmalate = dimethylmaleate + H2O"}, {"i": "EC:4.2.1.85", "l": "\"Dimethylmaleate hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66195", "l": "ATP + bilirubin-bisglucuronoside(in) + H2O <=> ADP + bilirubin-bisglucuronoside(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797554", "l": "ABP1 binds SHANK proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22385", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O => 1D-myo-inositol hexakisphosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25746", "l": "H(+) + N,N-dihydroxy-L-pentahomomethionine <=> (E)-8-(methylsulfanyl)octanal oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047890", "l": "flavanone 4-reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391934", "l": "DP2 receptor can bind PGD2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47578", "l": "CMP + ganglioside GD1c (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E))"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75862", "l": "Fall Back to Closed Pre-initiation Complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1297275", "l": "CD9:Izumo Binding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60231", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4717521", "l": "PIAS1 SUMOylates NR2C1 (TR2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40615", "l": "H2O + tridecanoylglycerol = 2,3-didecanoyl-sn-glycerol + decanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018754", "l": "GDIs bind RHOH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24552", "l": "5alpha-cholestan-3-one + NADP(+) = cholest-4-en-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390470", "l": "Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382058", "l": "Nck binds to the active PDGF receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853762", "l": "RET dimerizes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35983", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391939", "l": "TP receptor can bind thromboxane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388900", "l": "Neurotensin receptors can bind neurotensins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050288", "l": "sorbose dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35462", "l": "cholesterol + NAD(+) <=> cholest-5-en-3-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35367", "l": "(2E)-15-methylhexadecenoyl-CoA + H(+) + NADPH = isoheptadecanoyl-coA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62537", "l": "2 [Fe(II)cytochrome c] + digoxigenin + 3 H(+) => 2 [Fe(III)cytochrome c] + dihydrodigoxigenin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14374", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15204", "l": "6-hydroxymellein + S-adenosyl-L-methionine <=> 6-methoxymellein + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379864", "l": "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11804", "l": "an aromatic aldehyde + H2O + NAD(+) = an aromatic carboxylate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.29", "l": "\"Aryl-aldehyde dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102984", "l": "sulfoacetaldehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22232", "l": "H(+) + NADPH + presqualene diphosphate = diphosphate + NADP(+) + squalene"}, {"i": "EC:1.3.1.96", "l": "\"Botryococcus squalene synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019003", "l": "GDP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25369", "l": "H(+) + momilactone A + NADPH => 3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9008043", "l": "MAPK8 phosphorylation (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28297", "l": "(2E,6E)-farnesyl diphosphate <=> (E)-beta-caryophyllene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39144", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + NAD(+) => 3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77609", "l": "Binding of APOBEC-1 to form editosome (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45074", "l": "(9Z)-18-hydroxyoctadecenoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z)-octadecenoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9652277", "l": "ERBB2 binds trastuzumab (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "65.690062451777465", "identifiers": [{"i": "GO:0004672", "l": "protein kinase activity"}, {"i": "REACT:R-HSA-156832", "l": "INF-gamma induced phosphorylation of L13a (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24575", "l": "[(1->4)-alpha-D-glucosyl](n) + sucrose <=> [(1->4)-alpha-D-glucosyl](n+1) + D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17111", "l": "(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FMN + H(+) => FMNH2 + N-methylnicotinate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034386", "l": "4-aminobutyrate:2-oxoglutarate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0033765", "l": "steroid dehydrogenase activity, acting on the CH-CH group of donors"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10821", "l": "D-threo-isocitrate => D-erythro-isocitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23075", "l": "H(+) + oxaloacetate + phosphate <=> CO2 + H2O + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22831", "l": "1-(5-phospho-beta-D-ribosyl)-ATP + H2O <=> 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5688294", "l": "SIRT5 deacetylates Cytochrome C (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57435", "l": "3-methoxycatechol + O2 + reduced [NADH--hemoprotein reductase] <=> 1,2,3-trihydroxybenzene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38722", "l": "(R)-carnitine(out) + ATP + H2O <=> (R)-carnitine(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693536", "l": "ATM phosphorylates MDC1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1297444", "l": "Binding of cAMP to HCN channels (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28267", "l": "(2E,6E)-farnesyl diphosphate => (S)-beta-bisabolene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41969", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) => a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60712", "l": "(+)-artemisinic alcohol + NAD(+) = (+)-artemisinic aldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59973", "l": "decanoyl-CoA + L-seryl-[protein] => CoA + O-decanoyl-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52403", "l": "4-O-phospho-D-threonate + NAD(+) <=> 3-dehydro-4-O-phospho-L-erythronate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730903", "l": "Oligomerization of TRAF6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-888589", "l": "Release of GABA at the synapse (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65814", "l": "A + H2O + N(6)-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-2-(methylsulfanyl)adenosine(37) in tRNA => 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9690494", "l": "RHOB translocates to the endosome membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70427", "l": "PGM:Mg2+ isomerise G1P to G6P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13904", "l": "H2O + N-(aminomethyl)urea <=> N-(hydroxymethyl)urea + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11592", "l": "dihydromonacolin L-[lovastatin nonaketide synthase] + H2O = dihydromonacolin L carboxylate + H(+) + holo-[lovastatin nonaketide synthase]"}, {"i": "EC:3.1.2.31", "l": "\"Dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49785", "l": "chenodeoxycholoyl-CoA + taurine => CoA + H(+) + taurochenodeoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9646685", "l": "Aggresome dissociates from dynein and microtubule (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34216", "l": "4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+) => 4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951486", "l": "CD46 binds C4b (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36845", "l": "3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA => (13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40450", "l": "(2R)-pristanoyl-CoA <=> (2S)-pristanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46923", "l": "(E)-cinnamate + H(+) <=> CO2 + styrene"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050182", "l": "phosphate butyryltransferase activity"}, {"i": "MetaCyc:PHOSPHATE-BUTYRYLTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14558", "l": "H2O + raucaffricine => D-glucose + vomilenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40234", "l": "(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58089", "l": "1-(7Z,10Z,13Z,16Z-docosatetraenoyl)-glycerol + H2O => (7Z,10Z,13Z,16Z)-docosatetraenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851933", "l": "MET phosphorylates GAB1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4655440", "l": "CBX4 (Pc2) SUMOylates DNMT3A with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45849", "l": "(3R)-3-hydroxydodecanoyl-CoA + NADP(+) => 3-oxododecanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445705", "l": "Release Of ADP From Myosin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944227", "l": "Association of procollagen type XXII (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5604929", "l": "Activated protein C binds Protein S (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31605", "l": "(Z)-3-aminoacrylate + carbamate + H(+) => (Z)-3-ureidoacrylate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430190", "l": "p-SLP-76 binds NCK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13263", "l": "2-methylbut-2-enoyl-CoA + AH2 => 2-methylbutanoyl-CoA + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64181", "l": "an N-(fatty acyl)-L-tryptophan + H2O => a fatty acid + L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43867", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(in) <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27527", "l": "(2E,6E)-farnesyl diphosphate + H2O => (2E,6E)-farnesol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033960", "l": "N-methyl nucleosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2106615", "l": "Removal of siRNA passenger strand (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605797", "l": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17863", "l": "20-hydroxy-3-oxopregn-4-en-21-al => 21-hydroxyprogesterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49147", "l": "2-oxoglutarate + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose <=> dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65366", "l": "a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30317", "l": "7-methylxanthine + formaldehyde + H2O + NAD(+) => 1,7-dimethylxanthine + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70982", "l": "Fumarate + H2O <=> (S)-Malate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54882", "l": "(3R)-3-isopropenyl-6-oxoheptanoate + H(+) => (4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031847", "l": "type 1 neurotensin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18317", "l": "an L-alpha-amino acid = a D-alpha-amino acid"}, {"i": "EC:5.1.1.10", "l": "\"Amino-acid racemase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9608039", "l": "NR1H2,3 binds the PLIN1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9667914", "l": "ALK binds ligand midkine (MDK) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693540", "l": "MRN activates ATM (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13157", "l": "(R)-glycerate + CO2 + NADP(+) = 2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664646", "l": "Phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 bind PI3K (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12193", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16000", "l": "anthraniloyl-CoA + 2 H(+) + 2 NADH + O2 <=> 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30064", "l": "2-demethylmenaquinol-8 + S-adenosyl-L-methionine => H(+) + menaquinol-8 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34698", "l": "(2E,6E)-farnesyl diphosphate <=> Delta(6)-protoilludene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692315", "l": "OX40L binds OX40 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53378", "l": "H(+) + NADPH + uridine(16) in tRNA => 5,6-dihydrouridine(16) in tRNA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781953", "l": "YOD1 binds VCP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429698", "l": "PRKD1,2,3 phosphorylates COL4A3BP-2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395768", "l": "LPL hydrolyses TGs from mature CMs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.117"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51490", "l": "archaetidylethanolamine + CO2 => archaetidylserine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191072", "l": "Synthesis of Cx43 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102514", "l": "cyanidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9010647", "l": "ROBO3.1 binds AKAP5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389348", "l": "Activation of Rac1 by pVav1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35193", "l": "H2O + norsolorinic acid => noranthrone + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37303", "l": "ATP + glycyl-L-asparagine(out) + H2O = ADP + glycyl-L-asparagine(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814678", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56864", "l": "12 H(+) + 6 malonyl-CoA + NADH + 5 NADPH = (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + 6 CoA + 4 H2O + NAD(+) + 5 NADP(+)"}, {"i": "EC:2.3.1.281", "l": "\"Coelimycin P1 polyketide synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "78.047734625335977", "identifiers": [{"i": "GO:0004714", "l": "transmembrane receptor protein tyrosine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948027", "l": "RNASEs bind bacterial phospholipids (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31155", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) = (4S)-4-hydroxy-L-glutamate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52548", "l": "L-threonate + NAD(+) = 2-dehydro-L-erythronate + H(+) + NADH"}, {"i": "EC:1.1.1.411", "l": "\"L-threonate 2-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46937", "l": "(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) => ATP + H(+) + L-2-aminoadipate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694421", "l": "PP6 dephosphorylates SEC24 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62625", "l": "[glutaredoxin]-dithiol + a hydroperoxide => [glutaredoxin]-disulfide + an alcohol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944227", "l": "Association of procollagen type XXII (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.94"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265177", "l": "Exocyst complex formation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66116", "l": "2-oxobutanoate + L-glutamine = (2S)-2-aminobutanoate + 2-oxoglutaramate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1467269", "l": "Beta-defensins bind microbial membranes causing disruption (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21889", "l": "NADP(+) + OPC-8 => (10Z,15Z)-12-oxophytodienoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858428", "l": "FCAMR binds IgA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62299", "l": "(+)-premalbrancheamide + 2 chloride + 2 FAD + 4 H(+) <=> (+)-malbrancheamide + 2 FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20482", "l": "3'-phosphoadenylyl sulfate + coelenterazine h => adenosine 3',5'-bisphosphate + H(+) + luciferyl sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35856", "l": "1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159733", "l": "Furin cleaves pro-factor X to factor X (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1268025", "l": "SAM50 complex inserts proteins into mitochondrial outer membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034986", "l": "iron chaperone activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730892", "l": "Recruitment of VAV to p-SLP-76 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60484", "l": "CTP + UTP = cyclic CMP-UMP + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450494", "l": "HuR binds mRNAs in the nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939201", "l": "ESR dimerizes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "77.690207805941611", "identifiers": [{"i": "GO:0016855", "l": "racemase and epimerase activity, acting on amino acids and derivatives"}, {"i": "EC:5.1.1.-", "l": "\"Acting on amino acids and derivatives\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12553", "l": "(E)-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA => (E)-pinosylvin + 4 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797090", "l": "CCNK binds CDK12 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20377", "l": "3alpha-hydroxy-5alpha-androstan-17-one + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31498", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose <=> a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061603", "l": "molybdenum cofactor guanylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102925", "l": "solanine UDP-galactose galactosyltransferase activity"}, {"i": "MetaCyc:RXN-8875"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38574", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) <=> a 1,2-diacyl-sn-glycero-3-phosphocholine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13060", "l": "an N-acylneuraminate 9-phosphate + H2O <=> an N-acylneuraminate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663245", "l": "NR1D1 (REV-ERBA) binds heme, the NPAS2 gene, and recruits corepressors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982792", "l": "Growth hormone receptor binds JAK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59574", "l": "4-aminobutanoate + L-histidine => H2O + L-homocarnosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68603", "l": "ORC5 binds ORC2:ORC3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106099", "l": "2-keto-3-deoxy-L-rhamnonate aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944250", "l": "Association of procollagen type XXV (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951727", "l": "cAMP binds PKA tetramer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10561", "l": "4-hydroxy-1-pyrroline-2-carboxylate + H(+) + H2O => 2,5-dioxopentanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912790", "l": "CBL binds CRK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53630", "l": "(2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34668", "l": "C30 botryococcene + S-adenosyl-L-methionine => 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0036041", "l": "long-chain fatty acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23503", "l": "H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+) <=> 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12452", "l": "1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)"}, {"i": "EC:2.7.1.134", "l": "\"Inositol-tetrakisphosphate 1-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.17", "l": "\"3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13683", "l": "a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine => a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010328", "l": "auxin influx transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11233", "l": "3'-phosphoadenylyl sulfate + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52245", "l": "4 H(+) + 4 Mn(2+) + O2 => 2 H2O + 4 Mn(3+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38609", "l": "nicotinate-adenine dinucleotide phosphate => 2'-phospho-cyclic ADP-ribose + nicotinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.82", "l": "\"Glutamyl endopeptidase II\""}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015652", "l": "quaternary ammonium group:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21947", "l": "ATP + D-cellobiose <=> 6-phospho-beta-D-glucosyl-(1->4)-D-glucose + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389354", "l": "Activation of Vav1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390438", "l": "FAR2 reduces PalmCoA to HXOL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18528", "l": "3-methylbutanol + NADP(+) <=> 3-methylbutanal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65089", "l": "asperaculane E + O2 + reduced [NADPH--hemoprotein reductase] => asperaculane G + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42583", "l": "ATP + L-serine + tRNA(Sec) <=> AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29100", "l": "a menaquinone + 5 H(+)(in) + NADH => a menaquinol + 4 H(+)(out) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214880", "l": "DL dimer binds to TUB and phosphorylated PLL in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50313", "l": "2-oxopentanoate + H(+) => butanal + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5252001", "l": "ATP1B4 binds SNW1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607733", "l": "BCL10 binds CARD9 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57987", "l": "(20S)-ginsenoside Rg3 + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rd + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0071917", "l": "triose-phosphate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12509", "l": "loganate + S-adenosyl-L-methionine => loganin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44889", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O => 1-O-alkyl-sn-glycero-3-phosphate + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64708", "l": "butan-1-ol + NADP(+) = butanal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8943279", "l": "GGT dimers hydrolyse GSH (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264865", "l": "Caspase-mediated cleavage of Lamin A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874718", "l": "TTPA binds alpha-TOH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839102", "l": "BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21518", "l": "piperitenone => isopiperitenone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604368", "l": "Autocatalytic activation of bound proMMP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373875", "l": "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797974", "l": "LRRTMs bind NRXNs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.128", "l": "\"7-methylxanthine demethylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53554", "l": "18-hydroxy-(9S,10R)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9S,10R)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.-", "l": "\"Cysteine endopeptidases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189488", "l": "UROS transforms HMB to URO3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5681980", "l": "ATG12 binds ATG7 dimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19386", "l": "UDP-alpha-D-glucose + vomilenine => H(+) + raucaffricine + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085083", "l": "Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814153", "l": "ADO oxidises 2AET to HTAU (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103012", "l": "ferredoxin-thioredoxin reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47293", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21295", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42933", "l": "cytidine(32) in tRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5223313", "l": "ABCD4:LMBRD1 transports Cbl from lysosomal lumen to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40005", "l": "(Z)-biformene + diphosphate => ent-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2545203", "l": "Deacetylation of cleaved cohesin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868230", "l": "SNX9 recruits components of the actin polymerizing machinery (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74885", "l": "GUCYs converts GTP to cGMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004366", "l": "glycerol-3-phosphate O-acyltransferase activity"}, {"i": "RHEA:15325", "l": "an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + CoA"}, {"i": "EC:2.3.1.15", "l": "\"Glycerol-3-phosphate 1-O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22156", "l": "GDP + H2O = GMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14351", "l": "an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP => an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381087", "l": "Dimerization of PERK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188544", "l": "Assembly of M2 tetramers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209096", "l": "E2F1, E2F2, or E2F3 and SP1 bind p14ARF promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047906", "l": "fucosterol-epoxide lyase activity"}, {"i": "RHEA:10884", "l": "(24R,24(1)R)-fucosterol epoxide = acetaldehyde + cholesta-5,24-dien-3beta-ol"}, {"i": "EC:4.1.2.33", "l": "\"Fucosterol-epoxide lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162836", "l": "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448744", "l": "IL20RA binds IL20RB (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40679", "l": "(9Z)-octadecen-1-ol + 1-hexadecanoylglycerone 3-phosphate = 1-O-(9Z)-octadecenylglycerone 3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102447", "l": "rhamnetin 3'-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-13933"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942075", "l": "Peroxynitrite and carbon dioxide react to nitrosoperoxycarbonate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375395", "l": "C5a receptor binds C5a anaphylatoxin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.29", "l": "\"[Heparan sulfate]-glucosamine 3-sulfotransferase 2\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32049", "l": "adenosine 5'-pentaphosphate + AMP + 2 H(+) => H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0003954", "l": "NADH dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203070", "l": "Association of profilin with monomeric actin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42425", "l": "2-methylmaleate + H2O => (2R,3S)-3-methylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34812", "l": "NADP(+) + tetrahydrocurcumin => dihydrocurcumin + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046988", "l": "asioloorosomucoid beta-1,3-glucuronosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381727", "l": "RAP1A exchanges GDP for GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47166", "l": "CO2 + NADH + zymosterone => 4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10963", "l": "(S)-lactate <=> (R)-lactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373875", "l": "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382054", "l": "PDGF binds to extracellular matrix proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866304", "l": "pre-VLDL binds lipids to form VLDL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12303", "l": "S-adenosyl-L-methionine + uridine(47) in tRNA(Phe) <=> 3-[(3S)-3-amino-3-carboxypropyl]uridine(47) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53700", "l": "2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17783", "l": "formate + L-methionine => H2O + N-formyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047468", "l": "phosphoglucomutase (glucose-cofactor) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35888", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936963", "l": "IRAK2 induces TRAF6 oligomerization (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638006", "l": "ARL3 hydrolyzes GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047534", "l": "2-acetolactate mutase activity"}, {"i": "RHEA:16361", "l": "2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37232", "l": "H2O + L-alaninamide => L-alanine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047440", "l": "2-dehydro-3-deoxy-D-pentonate aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53094", "l": "2-hydroxy-3-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine => 2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39641", "l": "(2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H2O => (3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46731", "l": "(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2 <=> (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444100", "l": "PROT mediates L-proline uptake (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20131", "l": "adenine + D-ribose 5-phosphate => AMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30207", "l": "H2O + methylamine + 2 oxidized [amicyanin] = formaldehyde + 2 H(+) + NH4(+) + 2 reduced [amicyanin]"}, {"i": "EC:1.4.9.1", "l": "\"Methylamine dehydrogenase (amicyanin)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5633460", "l": "MDM2 binds TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050298", "l": "stizolobinate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204813", "l": "Interaction of Tie2 and Grb14 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5334794", "l": "FABPs bind LCFAs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36081", "l": "a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198756", "l": "ERK1/2 phosphorylates MSK1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3204303", "l": "MRE11 binds cytosolic DNA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13286", "l": "ATP + L-cysteine + L-glutamate => ADP + H(+) + L-gamma-glutamyl-L-cysteine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54474", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanoate => 1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851038", "l": "BTN3A1 binds prenylated phosphoantigens (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803890", "l": "SFN dimerizes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56638", "l": "2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47381", "l": "(25R)-3beta-hydroxycholest-5-en-7-one-26-al + H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta-hydroxycholest-5-en-7-one-26-oate + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34595", "l": "H(+) + isopentadecanoyl-CoA + L-serine = 3-dehydro-15-methylhexadecasphinganine + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53083", "l": "4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67017", "l": "a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] => a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30104", "l": "2,5-didehydro-D-gluconate + H(+) + NADH => 5-dehydro-D-gluconate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111879", "l": "PIP2 hydrolysis (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60612", "l": "1-octanoyl-sn-glycero-3-phosphocholine = 1-octanoyl-sn-glycero-2,3-cyclic phosphate + choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373342", "l": "CX3CR1 binds CX3CL1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050603", "l": "thiophene-2-carbonyl-CoA monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265428", "l": "Interaction of integrin alpha9beta1 with VCAM1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39849", "l": "a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+) => a 2-acylglycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54835", "l": "a jasmonyl-L-amino acid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 12-hydroxyjasmonyl-L-alpha-amino acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16629", "l": "(S)-malyl-CoA = acetyl-CoA + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430158", "l": "p-SLP-76 binds VAV (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68960", "l": "DNA polymerase epsilon binds at the origin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40831", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604629", "l": "FBXW7 promotes ubiquitination of p-NICD4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46391", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S,25R)-24,26-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41993", "l": "17beta-hydroxy-5alpha-androstan-3-one + NAD(+) => 5alpha-androstan-3,17-dione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9626848", "l": "S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22801", "l": "cycloeucalenol => obtusifoliol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783670", "l": "CRLF1 binds CLCF1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8856945", "l": "PP2A methylation by LCMT1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474196", "l": "Collagen type II degradation by MMP14 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21401", "l": "2-oxoglutarate + CoA + NADP(+) => CO2 + NADPH + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2219524", "l": "PDPK1 binds PIP2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56719", "l": "H2O + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein] <=> H(+) + S-disulfanyl-L-cysteinyl-[SoxY protein] + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694527", "l": "Loss of SAR1B GTPase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18750", "l": "[protein]-dithiol + NAD(+) => [protein]-disulfide + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29228", "l": "H(+)(in) + indole(in) => H(+)(out) + indole(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672083", "l": "KTN1 binds Kinesin-1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814374", "l": "Kazrin binds periplakin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22227", "l": "3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA <=> 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25481", "l": "acetoacetate + succinyl-CoA => acetoacetyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60663", "l": "1,4-benzoquinone + H(+) + NADH <=> hydroquinone + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050699", "l": "WW domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1977959", "l": "ERBB4 forms heterodimers with EGFR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030352", "l": "inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014320", "l": "SARM binds viral dsRNA:TLR3:TICAM1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103059", "l": "UDP-L-rhamnose:kaempferol 3-O-rhamnosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983300", "l": "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14602", "l": "L-lysine + O2 => 5-aminopentanamide + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989779", "l": "Expression of ANKRD1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54386", "l": "a 3-oxo-Delta(4)-steroid + H(+) + NADPH => a 3-oxo-5alpha-steroid + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004124", "l": "cysteine synthase activity"}, {"i": "MetaCyc:ACSERLY-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005185", "l": "neurohypophyseal hormone activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18987", "l": "isochorismate => chorismate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48521", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + H2O => [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + H(+) + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53028", "l": "lithocholate + UDP-alpha-D-glucuronate = H(+) + lithocholoyl-3-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2534096", "l": "METAP1/2 demethylates GNAT1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21417", "l": "NADP(+) + sn-glycerol 1-phosphate => dihydroxyacetone phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12182", "l": "H(+) + N-methylanthranilate + S-adenosyl-L-homocysteine => anthranilate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168921", "l": "TRIF:activated TLR3/TLR4 complex recruits RIP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0008515", "l": "sucrose transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850997", "l": "TRIM27 binds PTEN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202714", "l": "CD58 binds CD2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.3.1", "l": "\"Nitroalkane oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853496", "l": "SCF:FBXL7 binds AURKA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37747", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-octadecyl-sn-glycero-3-phosphocholine = 1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013006", "l": "RHOA:GTP translocates to the ER membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15798", "l": "bilirubin IXalpha + NAD(+) => biliverdin IXalpha + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985929", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110218", "l": "Cleavage of uracil by TDG glycosylase (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299482", "l": "TIMM23 SORT inserts proteins into inner membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11917", "l": "13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) => 15-oxoprostaglandin E2 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15928", "l": "dihydrobunolol + NADP(+) <=> bunolol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168456", "l": "Growth hormone receptor binds Lyn (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34361", "l": "a 2-acylglycerol + a carboxylate + H(+) => a 1,2-diacylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156930", "l": "GTP-binding activates eEF2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13380", "l": "alpha-D-glucose 1-phosphate + ATP <=> ADP + alpha-D-glucose 1,6-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38124", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol => 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38357", "l": "(E)-cinnamoyl-CoA + H2O => (R)-3-phenyllactoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23777", "l": "ATP + L-aspartate => 4-phospho-L-aspartate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47502", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => cholate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419645", "l": "Dimerization of LIMK1 by Hsp90 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45436", "l": "H2O + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine = H(+) + N-hexadecanoylethanolamine + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005542", "l": "folic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42577", "l": "2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + H2O => 2-methylpropanoate + 2-oxopent-4-enoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.-", "l": "\"Phosphoric diester hydrolases\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002114", "l": "interleukin-33 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209823", "l": "Tyrosine is hydroxylated to dopa (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937792", "l": "RUNX3 binds SRC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102459", "l": "8-oxo-deoxyadenine diphosphate phosphatase activity"}, {"i": "MetaCyc:RXN-14005"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-350901", "l": "Iodide is organified (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21455", "l": "a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 <=> a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879909", "l": "Activation of STAT5a/b by JAK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22244", "l": "kaempferol + UDP-alpha-D-xylose = H(+) + kaempferol 3-O-beta-D-xyloside + UDP"}, {"i": "EC:2.4.2.56", "l": "\"Kaempferol 3-O-xylosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48271", "l": "4',4'-dihydroxyechinenone <=> canthaxanthin + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000248", "l": "C-5 sterol desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41402", "l": "1-hexanoyl-sn-glycero-3-phosphate + choline + H(+) => 1-hexanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166817", "l": "Cleavage of C3 by C3 convertases (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61339", "l": "ATP + H2O + protoporphyrin IX(in) <=> ADP + H(+) + phosphate + protoporphyrin IX(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30235", "l": "H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33054", "l": "choline + NAD(+) <=> betaine aldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39670", "l": "a secondary alcohol + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) <=> a ketone + reduced coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30550", "l": "(3S)-hydroxyhexanoyl-CoA <=> (2E)-hexenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50885", "l": "(9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O => (9Z-octadecenoyl)-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950367", "l": "Expression of transaldolase 1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60464", "l": "2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = 2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029453", "l": "Phosphorylation of VAV (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53402", "l": "(13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46501", "l": "2-oxoglutarate + O2 + UMP => CO2 + phosphate + succinate + uridine-5'-aldehyde"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004494", "l": "methylmalonyl-CoA mutase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102118", "l": "gibberellin A4 carboxyl methyltransferase activity"}, {"i": "EC:2.1.1.276", "l": "\"Gibberellin A(4) carboxyl methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800794", "l": "PIDD1 associates with CRADD (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44305", "l": "a 1-acyl-sn-glycero-3-phosphate + dodecanoyl-CoA => a 1-acyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48064", "l": "ganglioside GD1b (d18:1(4E)) + H2O = ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39385", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+) => 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202969", "l": "Caspase mediated cleavage of beta-catenin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693761", "l": "FA2H hydroxylates CERA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687088", "l": "PKA phosphorylates MAPKAPK5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373342", "l": "CX3CR1 binds CX3CL1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22405", "l": "beta-D-galacturonate + NAD(+) => D-galactaro-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51229", "l": "17alpha-ethynylestradiol + 3'-phosphoadenylyl sulfate => 17alpha-ethynylestradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204779", "l": "Interaction of Tie2 with Ang1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51671", "l": "2 H(+) + mevastatin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pravastatin lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031749", "l": "D2 dopamine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58866", "l": "4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45319", "l": "H(+) + NADPH + prostaglandin D2 <=> 11beta-prostaglandin F2 + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38208", "l": "19-oxo-androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => estrone + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000215", "l": "tRNA 2'-phosphotransferase activity"}, {"i": "RHEA:23324", "l": "2'-phospho-[ligated tRNA] + NAD(+) = ADP-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide"}, {"i": "EC:2.7.1.160", "l": "\"2'-phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803527", "l": "ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13255", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 1,3,4-trisphosphate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193650", "l": "p75NTR binds to NADE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50711", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione <=> (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.32", "l": "\"Beta-lytic metalloendopeptidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030785", "l": "[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29507", "l": "(2E,6E)-farnesyl diphosphate = (-)-alpha-gurjunene + diphosphate"}, {"i": "EC:4.2.3.72", "l": "\"Alpha-gurjunene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37809", "l": "1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025007", "l": "Hydroperoxy reductase reduces 7(S),14(S)-diHp-DHA to 7-epi-MaR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190519", "l": "Internalization of gap junction plaques (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44841", "l": "(R)-carnitine + octadecanoyl-CoA => CoA + O-octadecanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56982", "l": "4-hydroxybenzaldehyde + 2 H(+) + 2 reduced [azurin] => 4-hydroxybenzyl alcohol + 2 oxidized [azurin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42734", "l": "N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(527) in 16S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358789", "l": "Self-ubiquitination of RNF41 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909729", "l": "Activation of JAK kinases (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11490", "l": "an all-trans-retinyl ester + CoA => all-trans-retinol + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63260", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H(+) + NADH = 4-pyridoxate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043911", "l": "D-lysine transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16562", "l": "H2O + squalene => hopan-22-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130619", "l": "TGN-lysosomal vesicle coat assembly (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-984606", "l": "Kinesin-5 is a homotetramer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13425", "l": "a pyrimidine ribonucleoside 5'-phosphate + H2O = a pyrimidine nucleobase + D-ribose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46886", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004571", "l": "mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61448", "l": "H(+) + NADPH + O2 + tigecycline = 11a-hydroxytigecycline + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.5", "l": "\"Cathepsin D\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12080", "l": "acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA"}, {"i": "EC:2.3.1.180", "l": "\"Beta-ketoacyl-[acyl-carrier-protein] synthase III\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047155", "l": "3-hydroxymethylcephem carbamoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191299", "l": "Squalene is oxidized to its epoxide (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190265", "l": "FGFR4 binds to FGF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071518", "l": "autoinducer-2 kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800794", "l": "PIDD1 associates with CRADD (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70475", "l": "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201603", "l": "Caspase-mediated cleavage of PKC theta (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784189", "l": "JAKs bind LIFR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004151", "l": "dihydroorotase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41517", "l": "O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47095", "l": "(S)-2,3-dihydrodipicolinate + NADP(+) <=> dipicolinate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44102", "l": "2 H(+) + NADH + octanoate => H2O + NAD(+) + octanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27399", "l": "beta-D-glucose + dichloroarcyriaflavin A => 4'-demethylrebeccamycin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75081", "l": "Formation of AT-AC B Complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1861788", "l": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63387", "l": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-octadecyl-2-acetyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3204311", "l": "AOX1 oxidises PXL to PDXate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36513", "l": "(11Z)-3-oxoicosenoyl-CoA + CO2 + CoA => (9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674095", "l": "PDGFRs bind type II TKI (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13440", "l": "(E)-cinnamate + UDP-alpha-D-glucose <=> 1-O-(trans-cinnamoyl)-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17371", "l": "2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate => glycyrrhizin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59117", "l": "[protein]-dithiol + O2 => [protein]-disulfide + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392870", "l": "Gs activation by prostacyclin receptor (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977071", "l": "Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19755", "l": "AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+) => ATP + diphthine-[translation elongation factor 2] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63401", "l": "Fe(II)-hydroxyheme i => Fe(II)-heme a + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55394", "l": "H(+) + N(1)-methyladenosine in mRNA + S-adenosyl-L-homocysteine => adenosine in mRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25461", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + sibirene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1362485", "l": "GHBP binds GH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9659820", "l": "RB1 translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50579", "l": "acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853800", "l": "ARTN binds RET:GFRA1,GFRA3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39089", "l": "(2E)-decenedioyl-CoA + H2O2 => decanedioyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427570", "l": "Group 3 - Selective Cl- transport (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4615910", "l": "SUMOylation of PCNA with SUMO1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210292", "l": "Interaction of DAP12 and TREM1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16146", "l": "2 [Fe(II)-cytochrome b5] + CMP-N-acetyl-beta-neuraminate + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + CMP-N-glycoloyl-beta-neuraminate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29807", "l": "ATP + H2O + L-leucine(out) = ADP + H(+) + L-leucine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65779", "l": "chlorotoluron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-(3-chloro-4-methylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682377", "l": "LC3 de-lipidation by ATG4 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17665", "l": "L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]"}, {"i": "EC:2.3.1.181", "l": "\"Lipoyl(octanoyl) transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029273", "l": "PI3K binds to p-6Y-SYK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54201", "l": "N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.16", "l": "\"HIV-1 retropepsin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990190", "l": "peptide-glutamate-N-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2288097", "l": "Condensin II complex binds H4K20me1-containing nucleosomes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983518", "l": "IL35 binds IL6ST:IL6ST receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689085", "l": "ATXN3 binds polyUb-PARK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008910", "l": "kanamycin kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372724", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59659", "l": "D-cellotriose + O2 <=> D-cellotriono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981728", "l": "Factor H binds to membrane-associated C3b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49808", "l": "a quinone + butan-1-ol = a quinol + butanal"}, {"i": "EC:1.1.5.11", "l": "\"1-butanol dehydrogenase (quinone)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44786", "l": "H(+) + menaquinol-10 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-10 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877192", "l": "RUNX1 binds FOXP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69068", "l": "RFC dissociates after sliding clamp formation (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44795", "l": "2-demethylmenaquinol-12 + S-adenosyl-L-methionine <=> H(+) + menaquinol-12 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655847", "l": "Expression of Lanosterol Demethylase (CYP51A1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54972", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-[ACP] = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20104", "l": "a long-chain fatty acid + ATP + L-cysteinyl-[protein] <=> AMP + diphosphate + S-(long-chain fatty acyl)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63977", "l": "A + dihydropyriculariol => AH2 + pyriculariol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53341", "l": "5,6-dihydrouridine(20) in tRNA + NAD(+) => H(+) + NADH + uridine(20) in tRNA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140575", "l": "transmembrane monodehydroascorbate reductase activity"}, {"i": "RHEA:66524", "l": "L-ascorbate(in) + monodehydro-L-ascorbate radical(out) = L-ascorbate(out) + monodehydro-L-ascorbate radical(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10909", "l": "3'-phosphoadenylyl sulfate + glycolithocholate => adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44522", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46120", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54442", "l": "a 4-H-anthocyanidin with a 3-hydroxy group + H2O => a (4S)-2,3-dehydroflavan-3,4-diol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017988", "l": "CRH gene expression is repressed by MECP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018804", "l": "RAC3 GEFs activate RAC3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59318", "l": "D-cellobiono-1,5-lactone + H2O2 => D-cellobiose + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199203", "l": "PANK1/3/4 phosphorylate PanK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1977959", "l": "ERBB4 forms heterodimers with EGFR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40180", "l": "decanoyl-CoA + O2 => (2E)-decenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22685", "l": "4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2 => (2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21657", "l": "CDP-alpha-D-paratose => CDP-3,6-dideoxy-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64719", "l": "NADP(+) + propanal <=> acrolein + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507870", "l": "Aquaporins passively transport water out of cells (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60662", "l": "hydroquinone + NAD(+) => 1,4-benzoquinone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44467", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol <=> 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674385", "l": "p-T,Y MAPKs dimerize (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3076905", "l": "Extracellular BTD hydrolyses BCTN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026927", "l": "GGT hydrolyses RCTR1 to RCTR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444047", "l": "Receptor FFAR3 binds carboxylates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10942", "l": "(4R)-limonene + diphosphate => (2E)-geranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66089", "l": "L-kynurenine + oxaloacetate => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48798", "l": "19-hydroxyprostaglandin H1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin H1 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28381", "l": "ATP + N(6)-(D-fructosyl)-L-lysine <=> ADP + H(+) + N(6)-(6-phospho-D-fructosyl)-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36178", "l": "1-O-alkylglycerone 3-phosphate + H(+) + NADPH <=> 1-O-alkyl-sn-glycero-3-phosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59089", "l": "D-histidine + S-adenosyl-L-methionine => (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65935", "l": "3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + S-adenosyl-L-methionine <=> 3,5-dimethyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44443", "l": "a 1,3-diacylglycerol + a 1-acylglycerol <=> a triacylglycerol + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429860", "l": "DCP1-DCP2 complex decaps mRNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15893", "l": "Co-sirohydrochlorin + 2 H(+) = Co(2+) + sirohydrochlorin"}, {"i": "RHEA:26269", "l": "Co-precorrin-2 + 3 H(+) = Co(2+) + precorrin-2"}, {"i": "EC:4.99.1.3", "l": "\"Sirohydrochlorin cobaltochelatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16698", "l": "A + H2O + quinaldate => AH2 + kynurenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.325", "l": "\"Sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19057", "l": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O"}, {"i": "EC:1.11.1.12", "l": "\"Phospholipid-hydroperoxide glutathione peroxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51728", "l": "dihydroxyacetone phosphate + H2O = dihydroxyacetone + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54119", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + pseudolaratriene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38401", "l": "(9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+) => 1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213210", "l": "Collagen IX is cross-linked to the surface of collagen type II fibrils (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1299338", "l": "Activation of TRESK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23514", "l": "beta-D-glucose 1-phosphate + D-glucose => alpha,alpha-trehalose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977619", "l": "CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008429", "l": "phosphatidylethanolamine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62030", "l": "D-glucose + stigmasterol => H2O + stigmasteryl 3-beta-D-glucoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47899", "l": "6-sulfo-D-quinovose + NAD(+) <=> 6-deoxy-6-sulfo-D-glucono-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008930", "l": "methylthioadenosine nucleosidase activity"}, {"i": "RHEA:13617", "l": "H2O + S-methyl-5'-thioadenosine = 5-(methylsulfanyl)-D-ribose + adenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42975", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a cardiolipin + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004370", "l": "glycerol kinase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102058", "l": "jasmonoyl-leucine synthetase activity"}, {"i": "MetaCyc:RXN-10459"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072550", "l": "triferuloylspermidine meta-hydroxylase activity"}, {"i": "MetaCyc:RXN-11262"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34490", "l": "dTDP-beta-L-rhamnose + N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol <=> alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65171", "l": "AH2 + O2 + preaustinoid A <=> A + H2O + preaustinoid A1"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015097", "l": "mercury ion transmembrane transporter activity"}, {"i": "RHEA:32815", "l": "Hg(2+)(in) = Hg(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15386", "l": "L-asparagine => 3-cyano-L-alanine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103025", "l": "alpha-amylase activity (releasing maltohexaose)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69173", "l": "Joining of adjacent Okazaki fragments (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60010", "l": "a tRNA with a 3' CC end + 2 diphosphate => a tRNA precursor + 2 CTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41451", "l": "2-oxoglutarate + L-isoleucine + O2 <=> (4S)-4-hydroxy-L-isoleucine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44544", "l": "a fatty acid(out) + ATP + H2O = a fatty acid(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009936", "l": "RNASEL cleaves cellular ssRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2471641", "l": "Defective OPN1MW causes COD5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209910", "l": "Iodide is taken up by thyroid epithelial cells (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017797", "l": "NOTCH3 binds YBX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10466", "l": "n acetate + chitosan => [(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.50", "l": "\"V-cath endopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39660", "l": "3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45017", "l": "5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine => L-selenomethionine + tetrahydropteroyltri-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49267", "l": "5-O-[(E)-caffeoyl]-shikimate + H2O <=> (E)-caffeate + H(+) + shikimate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028583", "l": "Phosphorylation of YAP by LATS2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165195", "l": "GTP loading by Rheb (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917730", "l": "Cargo Recognition And Sorting (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010331", "l": "gibberellin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40513", "l": "3-sulfolactaldehyde + H(+) + NADH => 2,3-dihydroxypropane-1-sulfonate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5649856", "l": "Oxidative damage to the AP site (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20434", "l": "NAD(+) + xylitol => D-xylulose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617848", "l": "CDKN1B gene expression is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990518", "l": "single-stranded 3'-5' DNA helicase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22543", "l": "5'-dehydroadenosine + H2O + O2 <=> 9-riburonosyladenine + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022073", "l": "Procollagen triple helix formation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40731", "l": "(20S)-ginsenoside Rg3 + 2 H2O = (20S)-protopanaxadiol + 2 D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25404", "l": "(S)-2-ethyl-2-hydroxy-3-oxobutanoate = (R)-3-hydroxy-3-methyl-2-oxopentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169398", "l": "ISGylation of host protein filamin B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51210", "l": "12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH => 20-hydroxy-leukotriene B4 + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43261", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008974", "l": "phosphoribulokinase activity"}, {"i": "MetaCyc:PHOSPHORIBULOKINASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71445", "l": "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47596", "l": "an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate = an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy- beta-D-glucuronosyl)-N-acetyl- alpha-D-glucosaminyl phosphate + H(+) + UDP"}, {"i": "EC:2.4.1.335", "l": "\"Dolichyl N-acetyl-alpha-D-glucosaminyl phosphate 3-beta-D-2,3-diacetamido-2,3-dideoxy-beta-D-glucuronosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2530445", "l": "CD59 inhibits MAC formation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59354", "l": "H2O2 + lactobiono-1,5-lactone => beta-lactose + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36227", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)"}, {"i": "EC:2.7.8.22", "l": "\"1-alkenyl-2-acylglycerol choline phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202727", "l": "Integrin alphaMbeta2 (MAC1) binds JAM3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47116", "l": "eicosanoate + glycine = H2O + N-eicosanoylglycinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014294", "l": "RAC2 binds effectors at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50844", "l": "(5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate = (5S,6S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4086083", "l": "SUMOylation of ING2 with SUMO1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20973", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine => 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163090", "l": "Elongation Of The Telomeric Chromosome End (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57201", "l": "glyoxal + L-arginyl-[protein] => N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20219", "l": "dimethylamine + formaldehyde => H(+) + trimethylamine N-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20617", "l": "L-galactono-1,4-lactone + O2 = H(+) + H2O2 + L-ascorbate"}, {"i": "EC:1.3.3.12", "l": "\"L-galactonolactone oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624948", "l": "KIF17 enters the cilium (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33475", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphinganine = a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11218", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + ADP => a 2'-deoxyribonucleoside 5'-phosphate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21261", "l": "[thioredoxin]-disulfide + H2O + L-methionine => [thioredoxin]-dithiol + L-methionine (R)-S-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176956", "l": "Formation of GINS complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671850", "l": "JAK2 Phosphoryates STAT3 in Response to Leptin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65673", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontenoyl)-sphing-4-enine => a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299487", "l": "Precursor proteins enter TIMM23 SORT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34988", "l": "(S)-lactate(in) => (S)-lactate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350443", "l": "PP1-87B:MBS complex dephosphorylates SQH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.3.14"}]}
{"type": "biolink:MolecularActivity", "ic": "74.159372409045062", "identifiers": [{"i": "GO:0008649", "l": "rRNA methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804100", "l": "HMGB1 binds LPS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24144", "l": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O"}, {"i": "EC:4.2.1.57", "l": "\"Isohexenylglutaconyl-CoA hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-912790", "l": "CBL binds CRK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60885", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine-phospho-ribonucleoside in mRNA + H2O => (N(7)-methyl 5'-triphospho-guanosine)-adenosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61622", "l": "[(1->2)-beta-D-mannosyl](n+1) + GDP + H(+) => [(1->2)-beta-D-mannosyl](n) + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811508", "l": "ING2-bound EP300 acetylates TP53 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24454", "l": "[protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine => L-glutamyl-[protein] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399996", "l": "AKT1 E17K mutant phosphorylates CREB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169406", "l": "ISGylation of host proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626549", "l": "IQGAPs bind CALM1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19574", "l": "[phosphate](n) + ATP => [phosphate](n+1) + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33217", "l": "all-trans-heptaprenyl diphosphate + 3 diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + 3 isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42225", "l": "A + testosterone => AH2 + androst-4-ene-3,17-dione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685319", "l": "CX3 complex formation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "69.756993955295187", "identifiers": [{"i": "GO:0004519", "l": "endonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15919", "l": "aldono-1,5-lactone + H(+) + NADH => an aldopyranose + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66450", "l": "(E)-2-pentenal + H(+) + NADPH => (E)-pent-2-en-1-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54430", "l": "ADP-D-ribose + H(+) + L-aspartyl-[protein] => 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1369028", "l": "ABCAs mediate lipid efflux (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54346", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19012", "l": "a 3-acylpyruvate + H2O <=> a carboxylate + H(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.98"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53918", "l": "CoA + H(+) + N(6)-acyl-L-lysyl-[protein] => an acyl-CoA + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798749", "l": "Exocytosis of specific granule lumen proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004978", "l": "corticotropin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.42", "l": "\"Complement subcomponent C1s\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45158", "l": "3-oxopropanoate + CoA + H(+) => 3-oxopropanoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665727", "l": "FMNL2 binds CDC42:GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429694", "l": "CERT:PPM1L:VAPA/B [ER] => CERT [cytosol] + PPM1L:VAPA/B [ER] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24907", "l": "L-tyrosine => (E)-4-coumarate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204824", "l": "Interaction of Tie2 and Ang4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851298", "l": "GPR143 binds L-Dopa (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39702", "l": "(R)-3-hydroxy-(13Z)-eicosenoyl-CoA <=> (2E,13Z)-eicosadienoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20696", "l": "2 H(+) + 2 superoxide = H2O2 + O2"}, {"i": "EC:1.15.1.1", "l": "\"Superoxide dismutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15469", "l": "1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide"}, {"i": "EC:5.3.1.16", "l": "\"1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.12", "l": "\"cGMP-dependent protein kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653974", "l": "Ragulator binds Rag dimers (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54647", "l": "trans-4-hydroxy-L-proline <=> (S)-1-pyrroline-5-carboxylate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53312", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27995", "l": "H2O + xanthosine => D-ribose + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37455", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446089", "l": "BP180 interacts extracellularly with Laminin 332 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74882", "l": "GNAT1-GDP binds to GNB1:GNGT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047946", "l": "glutamine N-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58417", "l": "(E)-4-hydroxynon-2-en-1-ol + NADP(+) => (E)-4-hydroxynon-2-enal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38241", "l": "1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA => (9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483209", "l": "PG is converted to BMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.242"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19904", "l": "L-tryptophan + O2 <=> alpha,beta-didehydrotryptophan + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26393", "l": "all-trans-zeaxanthin + 2 O2 = 2 (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial"}, {"i": "EC:1.14.99.n4", "l": "\"Carotenoid 9,10-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033266", "l": "ABC-type choline transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21216", "l": "ATP + D-ribose 5-phosphate = ADP + alpha-D-ribose 1,5-bisphosphate + H(+)"}, {"i": "EC:2.7.1.18", "l": "\"Phosphoribokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112392", "l": "Resumption of elongation after recovery from pausing (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35399", "l": "1-O-(trans-4-coumaroyl)-beta-D-glucose + cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) betaine = beta-D-glucose + cyanidin 3-O-[6-O-(6-O-4-hydroxycinnamoyl-beta-D-glucosyl)-2-O-beta-D-xylosyl-beta-D-galactoside] + H(+)"}, {"i": "EC:2.3.1.213", "l": "\"Cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) 6'''-O-hydroxycinnamoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66255", "l": "ATP + CoA + IC-asc-C7 <=> AMP + diphosphate + IC-asc-C7-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.21", "l": "\"2-dehydro-3-deoxy-6-phosphogalactonate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11046", "l": "a halide anion + glycolate + H(+) => a haloacetate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391933", "l": "EP3 receptor can bind PGE2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44932", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10770", "l": "(4S)-2,3-dehydroleucopelargonidin + CO2 + H(+) + H2O + succinate => (2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951977", "l": "Acetylated RUNX3 binds to BRD2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693125", "l": "RHOF binds effectors at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102653", "l": "gibberellin A51,2-oxoglutarate:oxygen oxidoreductase activity"}, {"i": "MetaCyc:RXN-172"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18801", "l": "(cis-prenyl)n-diphosphate + isopentenyl diphosphate = (cis-prenyl)(n+1)-diphosphate + diphosphate"}, {"i": "EC:2.5.1.20", "l": "\"Rubber cis-polyprenylcistransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62266", "l": "hydrogencarbonate(in) + selenite(in) + Zn(2+)(in) => hydrogencarbonate(out) + selenite(out) + Zn(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50065", "l": "ATP + H2O + taurochenodeoxycholate(in) => ADP + H(+) + phosphate + taurochenodeoxycholate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57494", "l": "2-methylcitrate + CoA + H(+) => H2O + oxaloacetate + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19455", "l": "L-glutamate + pyruvate => 2-oxoglutarate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64027", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8),N'(8)-citryl-bis(spermidine) <=> H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168136", "l": "Activated JNKs phosphorylate c-JUN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31886", "l": "(S)-2,3-epoxysqualene <=> delta-amyrin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389523", "l": "BTLA interacts with HVEM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11877", "l": "NAD(+) + prostaglandin E2 => 15-oxoprostaglandin E2 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32620", "l": "L-threo-7,8-dihydrobiopterin + NADP(+) => H(+) + NADPH + sepiapterin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45020", "l": "L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.298", "l": "\"Ribosomal protein L3 N(5)-glutamine methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15866", "l": "AH2 + O2 + tryptamine => 4-hydroxytryptamine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56363", "l": "13-deoxycarminomycin + H(+) + NADPH + O2 <=> 13-dihydrocarminomycin + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62088", "l": "D-glucosamine 6-phosphate + NADP(+) = 2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102188", "l": "4alpha-methyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity"}, {"i": "MetaCyc:RXN-11956"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190261", "l": "FGFR3c binds to FGF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18468", "l": "L-dopa + O2 <=> 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.131"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12629", "l": "2-oxoglutarate + L-hyoscyamine + O2 = (6S)-6-hydroxyhyoscyamine + CO2 + succinate"}, {"i": "EC:1.14.11.11", "l": "\"Hyoscyamine (6S)-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061677", "l": "2-dehydro-3-deoxy-D-gluconate aldolase activity"}, {"i": "MetaCyc:4.1.2.51-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781840", "l": "ERCC6 binds stalled RNA Pol II (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.48", "l": "\"Heteroglycan alpha-mannosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800315", "l": "MST1 binds MST1R (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669890", "l": "Constitutive phosphorylation of kinase domain KIT mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903136", "l": "cuprous ion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018756", "l": "RHOH binds GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5651828", "l": "PARG dePARylates PARP1,PARP2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "75.324974028080362", "identifiers": [{"i": "GO:0032451", "l": "demethylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196417", "l": "Reduction of desmosterol to cholesterol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68960", "l": "DNA polymerase epsilon binds at the origin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47862", "l": "ganglioside GD1b (d18:1(4E)) + N-acetylneuraminate => ganglioside GT1b (d18:1(4E)) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664933", "l": "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33117", "l": "malonate(out) => malonate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32332", "l": "(1S,2S,4R)-endo-fenchol + NAD(+) => (1S,4R)-fenchone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52746", "l": "alpha-isomaltosyl-(1->3)-isomaltose => cyclobis-(1->3)-alpha-isomaltosyl + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n14"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29424", "l": "ATP + diphosphate => ADP + H(+) + triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1564169", "l": "Collagen type VIII degradation by MMP1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4088220", "l": "Endorepellin binds alpha2beta1 integrin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25168", "l": "6-hydroxyhexan-6-olide = 6-oxohexanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22628", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate"}, {"i": "EC:6.3.2.6", "l": "\"Phosphoribosylaminoimidazolesuccinocarboxamide synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28306", "l": "beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose = beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)"}, {"i": "EC:2.4.1.251", "l": "\"GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol 4-beta-mannosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019726", "l": "mevaldate reductase (NADPH) activity"}, {"i": "RHEA:20193", "l": "(R)-mevalonate + NADP(+) = H(+) + mevaldate + NADPH"}, {"i": "EC:1.1.1.33", "l": "\"Mevaldate reductase (NADPH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46643", "l": "7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH <=> 7alpha-hydroxy-5beta-cholestan-3-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015186", "l": "L-glutamine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24170", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "ic": "63.684461498844783", "identifiers": [{"i": "GO:0016811", "l": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39865", "l": "1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008830", "l": "dTDP-4-dehydrorhamnose 3,5-epimerase activity"}, {"i": "RHEA:16969", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose"}, {"i": "EC:5.1.3.13", "l": "\"dTDP-4-dehydrorhamnose 3,5-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52891", "l": "N-phenylhydroxylamine + NADP(+) <=> H(+) + NADPH + nitrosobenzene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72139", "l": "Formation of the active Spliceosomal C (B*) complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52250", "l": "12 H(+) + 4 MnO2 => 6 H2O + 4 Mn(3+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0018822", "l": "nitrile hydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60099", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) <=> 4alpha-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202717", "l": "Heterodimerization of CEACAMs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061522", "l": "1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34306", "l": "L-lysine <=> L-pipecolate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211650", "l": "Autophosphorylation of PAK-2p34 in the activation loop (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46864", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli) = a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038174", "l": "interleukin-17A receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54486", "l": "1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine => 1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392530", "l": "p-S400-Cot phosphorylates NIK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211224", "l": "Association of DFF40 with DFF45 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549129", "l": "OCT1 transports organic cations into hepatic cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37628", "l": "(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine => 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13413", "l": "ADP + thymidine = AMP + dTMP + H(+)"}, {"i": "EC:2.7.1.118", "l": "\"ADP--thymidine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114354", "l": "SMAC binds XIAP:Caspase-7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229194", "l": "Depolymerization of lamin filaments after PKC-mediated phosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201515", "l": "Active ALK recruits PI3K (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34201", "l": "bracteatin 6-O-beta-glucoside + H2O => 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65544", "l": "ganglioside GM1 + H2O = an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-D-Glc"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30228", "l": "2 [Fe(III)-cytochrome c2] + dimethyl sulfide + H2O => 2 [Fe(II)-cytochrome c2] + dimethyl sulfoxide + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23765", "l": "diphosphate + L-serine => H(+) + O-phospho-L-serine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11479", "l": "glycerol 1-phosphate + H2O <=> glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047499", "l": "calcium-independent phospholipase A2 activity"}, {"i": "REACT:R-HSA-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052908", "l": "16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"}, {"i": "RHEA:19609", "l": "adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.182", "l": "\"16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51719", "l": "ATP(in) + CoA(in) + H(+)(out) + hexadecanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + hexadecanoyl-CoA(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60315", "l": "L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61233", "l": "H2O + L-isoleucine + O2 => (S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46961", "l": "butanoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (2E)-butenoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019977", "l": "interleukin-21 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45183", "l": "2 (E)-4-coumaroyl-CoA + spermidine <=> 2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56350", "l": "2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+) => 4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44284", "l": "2 H(+) + 2 malonyl-CoA + octanoyl-CoA = 4-hydroxy-6-heptylpyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16577", "l": "ADP + ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate"}, {"i": "EC:2.7.7.53", "l": "\"ATP adenylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000773", "l": "phosphatidyl-N-methylethanolamine N-methyltransferase activity"}, {"i": "MetaCyc:2.1.1.71-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182279", "l": "Formation of MHC I:Nef:AP-1:PACS-1 Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25997", "l": "H2O + N(1)-acetylspermine + O2 => H2O2 + N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47709", "l": "ADP + alpha-D-glucose 1-phosphate + H(+) => ADP-alpha-D-glucose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55696", "l": "a mannosylinositol-1-phospho-N-acyl-sphingoid base + H2O = an N-acyl-sphingoid base + H(+) + mannosylinositol-1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34332", "l": "H(+) + indole-3-pyruvate + NADPH + O2 => (indol-3-yl)acetate + CO2 + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49197", "l": "2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol => 25-hydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57611", "l": "(1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+) <=> 3-chlorocatechol + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29189", "l": "fumarate + ubiquinol-8 => succinate + ubiquinone-8"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005223", "l": "intracellular cGMP-activated cation channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46078", "l": "eicosanoyl-CoA + NAD(+) => (2E)-eicosenoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042301", "l": "phosphate ion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19942", "l": "norcoclaurine + S-adenosyl-L-methionine => coclaurine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43083", "l": "O2 + oleanolic aldehyde + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + oleanolate + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61503", "l": "delphinidin + UDP-alpha-D-glucose <=> delphinidin 3-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33635", "l": "ATP + CoA + docosanoate = AMP + diphosphate + docosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24871", "l": "5-deoxy-alpha-D-ribose 1-phosphate + adenine => 5'-deoxyadenosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015540", "l": "3-hydroxyphenyl propionate:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130478", "l": "Interaction of invariant chain trimer and MHC II alpha beta dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52841", "l": "4-hydroxy-3-methoxybenzoate + UDP-alpha-D-glucose => 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30692", "l": "H2O2 + methanol => formaldehyde + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47933", "l": "(S)-3-sulfolactaldehyde + H2O + NAD(+) => (R)-3-sulfolactate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51824", "l": "ATP(in) + CoA(in) + H(+)(out) + octanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + octanoyl-CoA(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434053", "l": "TRAF6 binds to p-IRAK2 complexed with activated TLR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008837", "l": "diaminopimelate epimerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419389", "l": "LPA-binding receptors bind LPA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63127", "l": "H2O + N-octadecanoyl ethanolamine <=> ethanolamine + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10970", "l": "an acyl-CoA + GDP + phosphate => a carboxylate + CoA + GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17624", "l": "acetyl-CoA + citramalate <=> (3S)-citramalyl-CoA + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-507871", "l": "Aquaporins passively transport glycerol out of cells (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202443", "l": "Oligomerization of CARMA1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64565", "l": "8-epi-ilicicolin H => ilicicolin H"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53829", "l": "2-oxoglutarate + a 5-hydroxymethyl-2'-deoxycytidine in DNA + O2 => a 5-formyl-2'-deoxycytidine in DNA + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789960", "l": "Expression of NDN,TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390930", "l": "5-HT2 receptor can bind serotonin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1008200", "l": "NFE2 binds the beta globin locus control region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23965", "l": "(E)-coniferaldehyde + H2O + NADP(+) => (E)-ferulate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388808", "l": "CD28 homodimer binds B7-2 monomer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783530", "l": "gp130:JAKs bind CNTFR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48633", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0000062", "l": "fatty-acyl-CoA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.16"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51315", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine <=> H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607734", "l": "PKC-delta translocates to plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9619355", "l": "CaMKK autophosphorylates in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948136", "l": "ULK1 Translocates to the mitochondria (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165162", "l": "Phosphorylation of TSC2 by PKB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709831", "l": "HSP90 binds TBK1 and IRF3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047832", "l": "D-pinitol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18952", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha,13alpha-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30032", "l": "(S)-muconolactone => cis,cis-muconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10596", "l": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29781", "l": "ADP + H(+) + L-methionine(in) + phosphate => ATP + H2O + L-methionine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24386", "l": "AMP + diphosphate + H(+) + L-glutamate + NAD(+) => ATP + deamido-NAD(+) + H2O + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49241", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) => L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16576", "l": "2-oxoglutarate + 4-(phosphooxy)-L-threonine <=> (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43257", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1564169", "l": "Collagen type VIII degradation by MMP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913360", "l": "GM-CSF receptor alpha subunit binds GM-CSF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912410", "l": "NOTCH4 mRNA translation controlled by miRNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44641", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + ATP => a 2'-deoxyribonucleoside 5'-triphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14972", "l": "S-adenosyl-L-methionine + trans-aconitate <=> (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983156", "l": "Polyubiquitination of substrate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34463", "l": "8-hydroxycopalyl diphosphate = cis-abienol + diphosphate"}, {"i": "EC:4.2.3.140", "l": "\"Cis-abienol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59024", "l": "H2O + trihexadecanoylglycerol = dihexadecanoylglycerol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28765", "l": "CoA + dTDP-4-acetamido-4,6-dideoxy-D-galactose + H(+) => acetyl-CoA + dTDP-4-amino-4,6-dideoxy-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59461", "l": "hexadecan-1-ol + NADP(+) => H(+) + hexadecanal + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37420", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49757", "l": "H(+) + O2 + protoviolaceinate => CO2 + H2O + proviolacein"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421835", "l": "trans-Golgi Network Vesicle Scission (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60160", "l": "ATP + H2O + vincristine(in) = ADP + H(+) + phosphate + vincristine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134914", "l": "Beta-catenin migrates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30806", "l": "4-aminobutanal + H2O + NADP(+) <=> 4-aminobutanoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606564", "l": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090684", "l": "contact chemoreceptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10153", "l": "ATP + hydrogencarbonate + NH4(+) => ADP + carbamoyl phosphate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042934", "l": "achromobactin transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0051723", "l": "protein methylesterase activity"}, {"i": "REACT:R-HSA-5367022", "l": "DPH7 hydrolyzes a methyl group on Me-diphthine EEF2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216061", "l": "SPP1 (osteopontin) binds integrin alpha8beta1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24213", "l": "5-(2-hydroxyethyl)-4-methylthiazole + ATP => 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007546", "l": "E2F6 binds RAD51 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48518", "l": "dodecanoate + dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) => 1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21983", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) <=> adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005080", "l": "protein kinase C binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102085", "l": "N-(4-aminobenzoyl)-L-glutamate synthetase activity"}, {"i": "MetaCyc:RXN-10884"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48980", "l": "3,4-dichlorocatechol + O2 = (2Z,4Z)-2,3-dichloromuconate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19786", "l": "2-oxoglutarate + dihydroclavaminate + O2 => clavaminate + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445704", "l": "Calcium Binds Caldesmon (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814088", "l": "SYS1 binds AcM-ARFRP1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102321", "l": "2,2'-hydroxybiphenyl monooxygenase activity"}, {"i": "MetaCyc:MONOMER-17239"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139909", "l": "Translocation of BMF to mitochondria (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396029", "l": "Latent TGF-beta-3 binds integrins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657665", "l": "ALKBH2 binds alkylated dsDNA containing 3-meC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010283", "l": "pinoresinol reductase activity"}, {"i": "MetaCyc:RXN-8678"}, {"i": "MetaCyc:RXN-8683"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024973", "l": "Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34593", "l": "Co-precorrin-8X + H(+) + S-adenosyl-L-homocysteine => Co-precorrin-7 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38877", "l": "pseudouridine(2604) in 23S rRNA => uridine(2604) in 23S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55400", "l": "7-cyano-7-carbaguanosine(15) in tRNA + NH4(+) = archaeosine(15) in tRNA"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0034416", "l": "bisphosphoglycerate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50812", "l": "androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58906", "l": "C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+) => 8 (S)-methylmalonyl-CoA + 24 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61109", "l": "(2R,3R)-dihydrokaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (2R,3R)-dihydromyricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005174", "l": "CD40 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621400", "l": "EGR2 and SREBF2 dimer bind SCD5 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603419", "l": "Activated NTRK3 binds SRC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.99.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44054", "l": "2-O-hexadecanoyl-alpha,alpha-trehalose + CoA => alpha,alpha-trehalose + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19029", "l": "3 H(+) + H2O + urea-1-carboxylate = 2 CO2 + 2 NH4(+)"}, {"i": "EC:3.5.1.54", "l": "\"Allophanate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111915", "l": "CAMK4 autophosphorylates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64236", "l": "atrochrysone carboxyl-[ACP] + H2O = atrochrysone carboxylate + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63694", "l": "a beta-D-glucuronoside + H(+) + UDP => alcohol glucuronate acceptor + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45345", "l": "globoside NOR1 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => globoside NORint (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16828", "l": "ATP + uridine <=> ADP + H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77094", "l": "Formation of cap binding complex (CBC) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8979082", "l": "Phosphorylated ETS2 binds p16INK4A promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202472", "l": "Translocation of TRAF6 to CBM complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938887", "l": "PML binds RUNX1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418874", "l": "Recruitment and activation of N-WASP by Cdc42 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50264", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 26-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30738", "l": "1D-myo-inositol 4-phosphate + H2O <=> myo-inositol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610879", "l": "GluN1 (GRIN1) binds to NEFL at postsynaptic density (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-560491", "l": "Expression of CEBPA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809680", "l": "MTMR12 binds MTM1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209792", "l": "N-acetylation of serotonin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49838", "l": "(5E)-tetradecenoyl-(R)-carnitine + CoA => (5E)-tetradecenoyl-CoA + (R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381091", "l": "IRE1 dimer autophosphorylates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446089", "l": "BP180 interacts extracellularly with Laminin 332 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000327", "l": "PLK1 phosphorylates BORA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65776", "l": "chlorotoluron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-(3-chloro-4-methylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22329", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) => diphosphate + thiamine phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419351", "l": "PAF receptor binds platelet activating factor (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72663", "l": "De novo formation of eIF2:GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866941", "l": "MID1IP1 binds THRSP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.25", "l": "\"Phenylalanine/tyrosine ammonia-lyase\""}]}
{"type": "biolink:MolecularActivity", "ic": "73.153983691316824", "identifiers": [{"i": "GO:0008375", "l": "acetylglucosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0019114", "l": "catechol dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953452", "l": "E2F6.com-1 complex binds the E2F1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53455", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + a cholesterol ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44176", "l": "a 2,3-diacyl-sn-glycerol + H2O = 3-acyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10333", "l": "a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34925", "l": "nitrate(out) => nitrate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25983", "l": "(5S)-albaflavenol + H(+) + NADPH + O2 <=> albaflavenone + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031800", "l": "type 3 metabotropic glutamate receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374896", "l": "Uptake of Noradrenaline (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19118", "l": "dopamine + 2 L-ascorbate + O2 => (R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008802", "l": "betaine-aldehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52003", "l": "a 1-(methylsulfanyl)-4-aci-nitroalkane + glutathione <=> an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47676", "l": "ATP + N-acetyl-D-galactosamine = ADP + H(+) + N-acetyl-D-galactosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44189", "l": "(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphate => 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39269", "l": "(3R)-hydroxy-(15Z)-tetracosenoyl-CoA + NADP(+) => (15Z)-3-oxotetracosenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204364", "l": "ROBO1 binds SLIT2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18199", "l": "cyclohexyl isocyanide + H2O => H(+) + N-cyclohexylformamide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042736", "l": "NADH kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980044", "l": "NOTCH1 binds JAG2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.21"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35686", "l": "hexadecasphinganine + NADP(+) <=> 3-oxohexadecasphinganine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388900", "l": "Neurotensin receptors can bind neurotensins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47669", "l": "H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) => 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873927", "l": "Release of STAT1 dimer from active receptor unit (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40079", "l": "docosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016768", "l": "spermine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34095", "l": "carboxyspermidine + H(+) = CO2 + spermidine"}, {"i": "RHEA:34099", "l": "carboxynorspermidine + H(+) = CO2 + norspermidine"}, {"i": "EC:4.1.1.96", "l": "\"Carboxynorspermidine decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30830", "l": "UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose <=> UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29245", "l": "menaquinol-8 + NAD(+) => H(+) + menaquinone-8 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38433", "l": "(9Z)-octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+) => 1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55322", "l": "2-heptanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl heptanoate + apo--[retinol-binding protein] => 1,2-diheptanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25002", "l": "(E)-phenylacetaldehyde oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50670", "l": "an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+) => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31582", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate <=> (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46646", "l": "5beta-dihydrocortisol + NADP(+) => cortisol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62229", "l": "(E)-ascladiol + A => AH2 + patulin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59855", "l": "(2S,3R)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH <=> (R)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15474", "l": "flavanone 7-O-beta-D-glucoside + UDP-beta-L-rhamnose => flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26106", "l": "homocitrate => cis-homoaconitate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004644", "l": "phosphoribosylglycinamide formyltransferase activity"}, {"i": "RHEA:15053", "l": "(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide"}, {"i": "EC:2.1.2.2", "l": "\"Phosphoribosylglycinamide formyltransferase 1\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47240", "l": "H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3095901", "l": "ABCC1 transports cytosolic Cbl to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0043860", "l": "cyanophycin synthetase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38027", "l": "(E)-caffeate + hydrocaffeoyl-CoA = (E)-caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)propanoate"}, {"i": "EC:2.8.3.23", "l": "\"Caffeate CoA-transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26178", "l": "1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+) => 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071208", "l": "histone pre-mRNA DCP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36207", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35988", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003983", "l": "UTP:glucose-1-phosphate uridylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203977", "l": "SAR1 Activation And Membrane Binding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58096", "l": "1-tetracosanoylglycerol + H2O = glycerol + H(+) + tetracosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2106625", "l": "Duplex siRNA is loaded into Argonaute (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28493", "l": "H(+)(in) + K(+)(in) <=> H(+)(out) + K(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016532", "l": "superoxide dismutase copper chaperone activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636461", "l": "PtpA binds Ubiquitin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932084", "l": "RUNX1 and ESR1 bind the AXIN1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39983", "l": "2 [Fe(II)-cytochrome b5] + a 1,2-saturated fatty acid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a 2-hydroxy fatty acid + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730886", "l": "Phosphorylation of SHC by SYK kinase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37778", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octanoyl-CoA <=> 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33312", "l": "2 A + hydroxylamine + NH4(+) => 2 AH2 + H(+) + H2O + N2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444859", "l": "Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199144", "l": "Nectin 2 binds CD226 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12170", "l": "acrolein + H(+) + NADPH => allyl alcohol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42313", "l": "H(+) + NADP(+) + 2 reduced [adrenodoxin] => NADPH + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61242", "l": "3-phenylpyruvate + H2O2 + NH4(+) => H2O + L-phenylalanine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446364", "l": "Migfilin interacts with VASP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805205", "l": "GPR35 binds kynurenic acid (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848663", "l": "ADIPOQ trimer binds ADIPOR dimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63207", "l": "H2O + octadecanoyl-[ACP] <=> H(+) + holo-[ACP] + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.11"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004820", "l": "glycine-tRNA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59300", "l": "3'-phosphoadenylyl sulfate + firefly D-luciferin = adenosine 3',5'-bisphosphate + firefly D-sulfoluciferin + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013147", "l": "RAC1 GDIs block activation of RAC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418856", "l": "Activation of Rac1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73797", "l": "FAICAR => IMP + H2O (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52207", "l": "butachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> butyl formate + H2O + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64314", "l": "dihydrogeodin + 2 FAD + H(+) + 4 H2O => 2 chloride + 2 FADH2 + 2 O2 + sulochrin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22155", "l": "a ubiquinone + D-glucose <=> a ubiquinol + D-glucono-1,5-lactone"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047388", "l": "[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase"}, {"i": "RHEA:43716", "l": "[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate = [glutamine synthetase]-L-tyrosine + ADP"}, {"i": "EC:2.7.7.89", "l": "\"[Glutamine synthetase]-adenylyl-L-tyrosine phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12371", "l": "2-dehydro-D-gluconate + A <=> 2,5-didehydro-D-gluconate + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49616", "l": "2-hydroxy-2-methylpropanal + H2O + NAD(+) = 2-hydroxy-2-methylpropanoate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.98", "l": "\"2-hydroxy-2-methylpropanal dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60699", "l": "(R)-lavandulyl diphosphate + H2O <=> (R)-lavandulol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47990", "l": "3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH => 2-dehydro-3-deoxy-L-galactonate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15083", "l": "acetyl-CoA + ADP + phosphate => acetate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678981", "l": "TLR9 processing at neutral pH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675790", "l": "MTORC1 dissociates from ULK complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33541", "l": "a carboxylate + ergosterol + H(+) => ergosteryl ester + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57963", "l": "dimethyl sulfide + H(+) + NADH + O2 <=> dimethyl sulfoxide + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042656", "l": "JUN kinase kinase kinase kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202394", "l": "Translocation of CARMA1 to Plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18605", "l": "1-amino-1-deoxy-scyllo-inositol + ATP = 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + H(+)"}, {"i": "EC:2.7.1.65", "l": "\"Scyllo-inosamine 4-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3791349", "l": "Defective EPM2A does not dephosphorylate phosphoglycogen (type 2A disease) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193684", "l": "p62 recruits an atypical PKC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5685230", "l": "CHEK1 phosphorylates RAD51 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60349", "l": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.135"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371590", "l": "HSP70 binds to HSP40:nascent protein (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038036", "l": "sphingosine-1-phosphate receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29844", "l": "ATP + CoA + propanoate => ADP + phosphate + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450422", "l": "KSRP recruits RNA degradation activities (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55424", "l": "(3S,6E)-nerolidol + O2 + reduced [NADPH--hemoprotein reductase] = (3E)-4,8-dimethylnona-1,3,7-triene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.59", "l": "\"Dimethylnonatriene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72722", "l": "eIF2 activation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50696", "l": "calciol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = calcidiol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432426", "l": "CRY is activated by light and binds to cytosolic TIM (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41907", "l": "3-oxohexadecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362437", "l": "C-terminal Hh fragments are bound by lectins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250253", "l": "TXNIP is released from oxidized thioredoxin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28941", "l": "H(+)(out) + xanthosine(out) => H(+)(in) + xanthosine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19146", "l": "D-glucose 6-sulfate + H2O => D-glucose + H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37753", "l": "2-methyl-cis-aconitate => 2-methyl-trans-aconitate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390835", "l": "DRD1,5 bind DA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36562", "l": "A + cis-4-hydroxy-D-proline <=> 4-hydroxy-1-pyrroline-2-carboxylate + AH2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23042", "l": "(R)-2-ethylmalate + CoA + H(+) => 2-oxobutanoate + acetyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.-", "l": "\"CoA-transferases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626220", "l": "C2CD3 binds the mother centriole (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672817", "l": "Active MTORC1 binds the ULK1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374665", "l": "DCC interaction with SIAH1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39617", "l": "(2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H2O => (3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60260", "l": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.354", "l": "\"[Histone H3]-lysine(4) N-trimethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62446", "l": "H(+) + L-arginine + L-canaline => L-canavanine + L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112396", "l": "Separation of elongating transcript from template (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244404", "l": "botB HC transports botB LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033427", "l": "CAA codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64604", "l": "L-seryl-[protein] + UTP = diphosphate + uridylyl-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388809", "l": "CTLA-4 binds B7-1/B7-2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58214", "l": "dihydroserpentine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ajmalicine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58762", "l": "1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADP(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8981931", "l": "RAC1 and CDC42 activate PAK2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35847", "l": "ATP + sphing-4-enine = ADP + H(+) + sphing-4-enine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202718", "l": "Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45132", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203716", "l": "eNOS:Caveolin-1 complex binds to Nostrin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9639286", "l": "RRAGC,D exchanges GTP for GDP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937989", "l": "RUNX1 binds PRC1 complexes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851352", "l": "CCR8 binds CCL1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42053", "l": "9-cis-retinol + NAD(+) => 9-cis-retinal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937613", "l": "CRHBP binds CRH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012186", "l": "CHD1 translation is negatively regulated by miR-26A and B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22213", "l": "(2R,3R)-tartrate => (2R,3S)-tartrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692749", "l": "CDC14A,B bind MAPK6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47227", "l": "3beta-sulfooxy-androst-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta-sulfooxy-16alpha-hydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31772", "l": "an all-trans-retinyl ester + H2O => 11-cis-retinol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0042289", "l": "MHC class II protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49389", "l": "UDP-alpha-D-glucose + validoxylamine A => H(+) + UDP + validamycin A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48970", "l": "[thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O => [thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607736", "l": "MALT1 oligomerizes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31877", "l": "marneral => (S)-2,3-epoxysqualene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24788", "l": "3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2 <=> 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49572", "l": "Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)"}, {"i": "EC:4.99.1.9", "l": "\"Coproporphyrin ferrochelatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26227", "l": "abieta-7,13-dien-18-oate + 2 H(+) + NADH => abieta-7,13-dien-18-al + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18876", "l": "3-chloro-D-alanine + H2O <=> chloride + H(+) + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876789", "l": "CARNMT1 methylates CARN to Anserine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0005354", "l": "galactose transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53957", "l": "gamma-L-glutamyl-[BtrI ACP] + H(+) => 4-aminobutanoyl-[BtrI ACP] + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0008517", "l": "folic acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16530", "l": "ADP + H(+) + sulfate => adenosine 5'-phosphosulfate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49760", "l": "EDTA + FMNH2 + O2 = ethylenediaminetriacetate + FMN + glyoxylate + 2 H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56519", "l": "Fe-coproporphyrin III + 2 H(+) + 2 H2O2 <=> 2 CO2 + 4 H2O + heme b"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50176", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma-aminobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49873", "l": "(+)-dehydrodiconiferyl acid ketone + a quinone + H2O => (+)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050335", "l": "thiocyanate isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34712", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine => 15-methylhexadecasphing-4-enine + a fatty acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40190", "l": "(2E)-octenoyl-CoA + H2O <=> (3R)-hydroxyoctanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "73.344328060803463", "identifiers": [{"i": "GO:0015101", "l": "organic cation transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371422", "l": "ATP hydrolysis by HSP70 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57243", "l": "glyoxal + GMP <=> N(2)-(1-hydroxy-2-oxoethyl)-GMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40650", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41798", "l": "a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033188", "l": "sphingomyelin synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49286", "l": "CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate => 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9691174", "l": "RAC1 binds effectors at the ER membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-392749", "l": "Transport of L1 into endosomes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.104"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3782535", "l": "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010294", "l": "abscisic acid glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202212", "l": "Recruitment of PLC-gamma1 to LAT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43544", "l": "ATP + L-glutamate + tyramine = ADP + gamma-L-glutamyltyramine + H(+) + phosphate"}, {"i": "EC:6.3.4.24", "l": "\"Tyramine--L-glutamate ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034818", "l": "ADD 9alpha-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72722", "l": "eIF2 activation (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45976", "l": "3-oxochola-1,4-dien-22-oate + H(+) + NADH + O2 = 9alpha-hydroxy-3-oxochola-1,4-dien-22-oate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57765", "l": "2,6-dinitrotoluene + NADH + O2 => 3-methyl-4-nitrocatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60734", "l": "2 H(+) + NADPH + perillate => H2O + NADP(+) + perillyl aldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72647", "l": "Cap-bound mRNA is activated by helicases  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22009", "l": "L-homoserine + succinyl-CoA => CoA + O-succinyl-L-homoserine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38066", "l": "2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA <=> 1-dodecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0070990", "l": "snRNP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52756", "l": "an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O = an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-cysteinylglycine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37675", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25167", "l": "A + butanoyl-CoA <=> (2E)-butenoyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070406", "l": "glutamine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149454", "l": "Packaging of HIV virion on the host cell plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.1.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873918", "l": "Transphosphorylation of JAK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34672", "l": "3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + S-adenosyl-L-methionine => 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62668", "l": "deoxyherqueinone + H(+) + NADPH + O2 = H2O + herqueinone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.3.1", "l": "\"NAD(P)H oxidase (H(2)O(2)-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61275", "l": "H2O + L-2-aminopentanoate + O2 <=> 2-oxopentanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404140", "l": "NREH hydrolyses atREs to atROL and FAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21491", "l": "dalnigrein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O <=> beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalnigrein + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449803", "l": "IL10 dimer binds IL10RA:JAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390909", "l": "HRH2 binds hist (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5138459", "l": "WNT5A:FZD4 is endocytosed (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57553", "l": "[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + O2 + reduced [NADPH--hemoprotein reductase] => (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29036", "l": "ATP + H2O + L-glutamate(out) => ADP + H(+) + L-glutamate(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.-.-", "l": "\"Acting on carbon-nitrogen bonds, other than peptide bonds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32489", "l": "CMP + 2 H(+) + phosphocholine => CDP-choline + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13735", "l": "an alk-2-enal + H(+) + NADH => an n-alkanal + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17016", "l": "H(+) + phosphoenolpyruvate <=> 3-phosphonopyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33714", "l": "4-sulfomuconolactone + H2O <=> 2 H(+) + maleylacetate + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27854", "l": "(2E)-geranyl diphosphate + 4-hydroxybenzoate = 3-geranyl-4-hydroxybenzoate + diphosphate"}, {"i": "EC:2.5.1.93", "l": "\"4-hydroxybenzoate geranyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35987", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12710", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38282", "l": "(3R)-citramalate + succinyl-CoA <=> (3R)-citramalyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46026", "l": "(3R)-hydroxytetradecanoate + H2O => H2O2 + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876230", "l": "InlB:MET dimer trans-autophophorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63829", "l": "L-alanine + vanillin => pyruvate + vanillylamine"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015247", "l": "aminophospholipid flippase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168929", "l": "Viral dsRNA:TLR3 recruits TRIF (TICAM1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1222376", "l": "NOX2 generates superoxide from oxygen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635854", "l": "GLI2,3 are degraded by the proteasome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15734", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O => (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33675", "l": "H2O + N-(2,3-dihydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+) = H(+) + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865182", "l": "OTUD7A hydrolyses K11diUb (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12673", "l": "an aliphatic amide = a nitrile + H2O"}, {"i": "EC:4.2.1.84", "l": "\"Nitrile hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45571", "l": "[heparosan](n) <=> [acharan](n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689972", "l": "USP2 deubiquitinates MDM2,MDM4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64170", "l": "(2S)-2-aminobutanoate + formaldehyde => 2-ethyl-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177501", "l": "Endocytosis (internalization) of clathrin-coated vesicle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015169", "l": "glycerol-3-phosphate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0005152", "l": "interleukin-1 receptor antagonist activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64437", "l": "glycylglycyl-L-isoleucine(out) + H(+)(out) => glycylglycyl-L-isoleucine(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52846", "l": "1-O-(3,4-dihydroxy-benzoyl)-beta-D-glucose + UDP => 3,4-dihydroxybenzoate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098697", "l": "ryanodine-sensitive calcium-release channel activity involved in regulation of postsynaptic cytosolic calcium levels"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64601", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166869", "l": "TRAF6 binds MEKK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11588", "l": "A + H2O + isoquinoline = AH2 + isoquinolin-1(2H)-one"}, {"i": "EC:1.3.99.16", "l": "\"Isoquinoline 1-oxidoreductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13164", "l": "L-threonine + NAD(+) <=> (2S)-2-amino-3-oxobutanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43296", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322427", "l": "Beta-catenin recruits CBP/p300 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672304", "l": "IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9641111", "l": "Parkin transfers Ub to misfolded proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11424", "l": "ATP + L-threonyl-[myosin heavy-chain] = ADP + H(+) + O-phospho-L-threonyl-[myosin heavy-chain]"}, {"i": "EC:2.7.11.7", "l": "\"[Myosin heavy-chain] kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53282", "l": "D-erythrulose => D-threose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66604", "l": "a 2'-deoxycytidine in double-stranded DNA + H(+) + H2O = a 2'-deoxyuridine in double-stranded DNA + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17232", "l": "acetyl-CoA + an aliphatic alcohol <=> an acetyl ester + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51038", "l": "2 H2O + indole-3-pyruvate imine dimer => 2 2-iminio-3-(indol-3-yl)propanoate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14162", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 => 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40930", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204863", "l": "Interaction of Tie2 with Ang2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70501", "l": "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57417", "l": "H2O + L-asparaginyl-[protein] => L-aspartyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31517", "l": "2 H(+) + NADH + neurosporaxanthin => 4'-apo-beta-carotenal + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42109", "l": "(20S)-hydroxypregn-4-en-3-one + NAD(+) => H(+) + NADH + progesterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183072", "l": "EGFR non-clathrin mediated endocytosis (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12023", "l": "a monocarboxylic acid amide + H2O <=> a monocarboxylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62277", "l": "3 (R)-2-hydroxy-3-methylbutyrate + 6 ATP + 3 L-phenylalanine + 3 S-adenosyl-L-methionine => 6 AMP + beauvericin + 6 diphosphate + 6 H(+) + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864426", "l": "TFAP2A,TFAP2C homodimers bind the CGB gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36884", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36752", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose => beta-D-Gal-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53568", "l": "12,13-epoxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-12,13-epoxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22662", "l": "a fatty acyl-[ACP] + AMP + diphosphate => a fatty acid + ATP + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63258", "l": "1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) => 1-octadecanoyl-2-(15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.6", "l": "\"Alanine carboxypeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687099", "l": "p-S857 NCOA3:ETV4 bind MMP2 and MMP10 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23839", "l": "D-methionine + pyruvate <=> 4-methylsulfanyl-2-oxobutanoate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112271", "l": "The receptor:G-protein complex dissociates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66626", "l": "(25S)-3-oxocholest-4-en-26-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => cholest-4-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158959", "l": "urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663170", "l": "p-BMAL1:p-CLOCK,NPAS2 binds BHLHE40 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65594", "l": "4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 8-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029155", "l": "JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17993", "l": "ATP + beta-alanine + L-gamma-glutamyl-L-cysteine = ADP + gamma-L-glutamyl-L-cysteinyl-beta-alanine + H(+) + phosphate"}, {"i": "EC:6.3.2.23", "l": "\"Homoglutathione synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612516", "l": "EGR1 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66180", "l": "ATP + bilirubin-glucuronoside(in) + H2O = ADP + bilirubin-glucuronoside(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5632738", "l": "DDIT4 binds 14-3-3 dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17791", "l": "(S)-reticuline + H(+) + S-adenosyl-L-homocysteine => (S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40698", "l": "1-hexadecanoylglycerone 3-phosphate + heptadecan-1-ol <=> 1-O-heptadecylglycerone 3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41695", "l": "1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.41", "l": "\"Yapsin 1\""}]}
{"type": "biolink:MolecularActivity", "ic": "76.711710297129045", "identifiers": [{"i": "GO:0004857", "l": "enzyme inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432067", "l": "Aquaporin-4 passively transports water out of cell (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57767", "l": "2,6-dinitrotoluene + NADH + O2 <=> 3-methyl-4-nitrocatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32328", "l": "10-hydroxy-alpha-humulene + NAD(+) => H(+) + NADH + zerumbone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25875", "l": "H2O2 + pyridine <=> H2O + pyridine N-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592297", "l": "Full activation of MMP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53450", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043786", "l": "cinnamate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15714", "l": "a beta-D-galactoside + acetyl-CoA => a 6-acetyl-beta-D-galactoside + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0030276", "l": "clathrin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40573", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67084", "l": "ATP + H2O + hexacosanoate(in) = ADP + H(+) + hexacosanoate(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27921", "l": "H2O + NADP(+) + propanal <=> 2 H(+) + NADPH + propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9005988", "l": "MECP2 binds the TRPC3 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28982", "l": "H(+)(out) + nitrite(in) <=> H(+)(in) + nitrite(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917730", "l": "Cargo Recognition And Sorting (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28536", "l": "diphosphate + dTMP + H(+) => dTTP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12628", "l": "(S)-malate + 1-O-(trans-sinapoyl)-beta-D-glucose <=> D-glucose + sinapoyl (S)-malate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876484", "l": "NPC2 transfers CHOL to NPC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70510", "l": "LDH tetramer oxidises LACT to PYR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44817", "l": "1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+) => 2-demethylmenaquinol-12 + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52647", "l": "D-xylono-1,4-lactone 5-phosphate + H2O <=> 5-phospho-D-xylonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51680", "l": "(2E,6E)-farnesol + CTP = (2E,6E)-farnesyl phosphate + CDP + H(+)"}, {"i": "EC:2.7.1.216", "l": "\"Farnesol kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51435", "l": "(S)-1-aminoethylphosphonate + acetyl-CoA <=> [(1S)-1-acetamidoethyl]phosphonate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15347", "l": "AMP + diphosphate + H(+) + L-tyrosyl-L-arginine => ATP + L-arginine + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53320", "l": "alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose = alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)"}, {"i": "EC:2.4.1.349", "l": "\"Mannosyl-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18852", "l": "a 2'-unsubstituted isoflavone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 2'-hydroxyisoflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33421", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate => [(1R)-2,2,3-trimethyl-2-oxocyclopent-3-en-1-yl]acetate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684006", "l": "KPNA2 translocates NBN to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444523", "l": "CXCR5 binds CXCL13 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59626", "l": "4-aminobutanoate + L-ornithine => H2O + N(2)-(4-aminobutanoyl)-L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050036", "l": "L-threonate 3-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22838", "l": "a 3-oxoacyl-[ACP] + CO2 + holo-[ACP] => a fatty acyl-[ACP] + H(+) + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43087", "l": "cytidine(34) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682983", "l": "ATM phosphorylates WHSC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948034", "l": "FGR binds LDL:LRP8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26562", "l": "2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O"}, {"i": "EC:4.1.3.36", "l": "\"1,4-dihydroxy-2-naphthoyl-CoA synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12804", "l": "ATP + L-seryl-[tau protein] <=> ADP + H(+) + O-phospho-L-seryl-[tau protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062066", "l": "PSII associated light-harvesting complex II binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614271", "l": "Autocleavage of ADGRG6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22769", "l": "4-nitrophenyl-3-ketovalidamine => 4-nitroaniline + 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26134", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+) => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20352", "l": "H(+) + NADH + O2 + toluene <=> 2-hydroxytoluene + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002046", "l": "opsin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20208", "l": "methylazoxymethanol + UDP-alpha-D-glucose <=> cycasin + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15628", "l": "Co-precorrin-6B + NAD(+) <=> Co-precorrin-6A + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975633", "l": "atROL binds to RBP2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45546", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64642", "l": "lactose + N-acetylneuraminate => H2O + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18910", "l": "2,4,6-trichlorophenol + S-adenosyl-L-methionine => 2,4,6-trichloroanisole + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63392", "l": "A + Fe(II)-heme o + H2O = AH2 + Fe(II)-heme i"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37119", "l": "7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine = 2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe)"}, {"i": "EC:2.3.1.231", "l": "\"tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19832", "l": "a primary alcohol + O2 <=> an aldehyde + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38414", "l": "1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + 1,3-di-(9Z,12Z,15Z)-octadecatrienoylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804266", "l": "CHEK2 phosphorylates TTC5 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48638", "l": "15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450474", "l": "MK2 phosphorylates BRF1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928627", "l": "EPHB phosphorylates TIAM1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50735", "l": "4-hydroxyphenylacetonitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-4-hydroxymandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017921", "l": "OPRM1 gene expression is repressed by MECP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389919", "l": "Grb2 binds pBTLA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35466", "l": "5alpha-cholest-7-en-3beta-ol + NAD(+) <=> 5alpha-cholest-7-en-3-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51999", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> a 1-(methylsulfanyl)-4-aci-nitroalkane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33583", "l": "L-glutamate + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate = 2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate"}, {"i": "EC:2.6.1.98", "l": "\"UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52787", "l": "2-sulfenohercynine + AH2 + H(+) <=> A + ergothioneine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14358", "l": "ATP + riboflavin => ADP + FMN + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60815", "l": "2-oxoglutarate + gibberellin A12 aldehyde + O2 <=> CO2 + gibberellin A12 + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112396", "l": "Separation of elongating transcript from template (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690196", "l": "USP8 deubiquitinates RNF128 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211191", "l": "Association of DFF with alpha:beta importin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676598", "l": "TRAF2:cIAP1/2 complex binds FN14:TWEAK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169394", "l": "ISGylation of IRF3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604752", "l": "Initial activation of proMMP13 by MMP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928615", "l": "EFNBs bind SFKs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174731", "l": "Degradation of newly synthesized ApoB-48 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70592", "l": "PXLP-K259-GOT1 dimer deaminates L-Asp (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-380930", "l": "Phosphorylated AMPK binds AMP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33101", "l": "CoA + H(+) + N(1)-acetylspermine => acetyl-CoA + spermine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52825", "l": "(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 => (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22534", "l": "(3S)-hydroxyoctanedioyl-CoA => (2E)-octenedioyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53704", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O = H(+) + prostaglandin E2 + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58665", "l": "(S)-2-hydroxyglutarate + a quinone => 2-oxoglutarate + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879322", "l": "mycothione is reduced to mycothiol (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51882", "l": "(2Z,4E)-2,3,5-trichloromuconate + H(+) => 3,4,6-trichlorocatechol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53768", "l": "allocholate + allodeoxycholoyl-CoA = allocholoyl-CoA + allodeoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48388", "l": "alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694442", "l": "CNIH2,3 bind GRIA1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49053", "l": "asperlicin C + H(+) + NADH + O2 => asperlicin E + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21636", "l": "(E)-4-coumarate + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-trans-4-coumarate + H(+) + UDP"}, {"i": "EC:2.4.1.126", "l": "\"Hydroxycinnamate 4-beta-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18510", "l": "H(+) + H2O2 + NADH => 2 H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25302", "l": "7,8-dihydroneopterin 3'-triphosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+)"}, {"i": "EC:3.6.1.67", "l": "\"Dihydroneopterin triphosphate diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18502", "l": "ergosterol + NADP(+) => ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45942", "l": "4-hydroxy-6-(13-methyl-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA => 12-methyloctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5688797", "l": "ATXN3 family cleave Ub chains (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40223", "l": "4,8-dimethylnonanoyl-CoA + H2O = 4,8-dimethylnonanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43197", "l": "adenosine(4) in tRNA(His) + S-adenosyl-L-methionine => 2'-O-methyladenosine(4) in tRNA(His) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33107", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + gamma-muurolene"}, {"i": "EC:4.2.3.126", "l": "\"Gamma-muurolene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52168", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22022", "l": "ADP + H(+) + molybdate(in) + phosphate => ATP + H2O + molybdate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24839", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate <=> 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39167", "l": "H(+) + malonyl-CoA + tetradecanoyl-CoA = 3-oxohexadecanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48124", "l": "ganglioside GD3 (d18:1(4E)) + H2O = ganglioside GM3 (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9706399", "l": "RHOBTB3 hydrolyzes ATP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43003", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1011598", "l": "DOCKs bind to RhoGEFs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54502", "l": "beta-geranylfarnesene + diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.17", "l": "\"Non-specific polyamine oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50626", "l": "a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+) => acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35753", "l": "ADP + D-kanosamine 6-phosphate + H(+) => ATP + kanosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42708", "l": "guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.33", "l": "\"tRNA (guanine(46)-N(7))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350604", "l": "Agmatine + H2O <=> putrescine + urea (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19923", "l": "D-ribulose 5-phosphate + H(+) + NADPH => D-ribitol 5-phosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66305", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-mannosylinositol-1-phosphoceramide => a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-alpha-mannosylinositol-1-phosphoceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12125", "l": "4-coumaroyl-CoA + shikimate => CoA + trans-4-coumaroylshikimate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035447", "l": "mycothiol synthase activity"}, {"i": "MetaCyc:MONOMER-9684"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444527", "l": "FPR is a receptor for formyl peptides (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59160", "l": "ATP + docosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] = AMP + diphosphate + docosanoyl-[(phenol)carboxyphthiodiolenone synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008137", "l": "RUNX2 binds ZNF521 and HDAC3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9641111", "l": "Parkin transfers Ub to misfolded proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47315", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49004", "l": "aurachin C + H(+) + NADPH + O2 = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8935732", "l": "RUNX1 binds SIN3A,(SIN3B) co-repressor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5368588", "l": "DVL binds CCDC88C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031771", "l": "type 1 hypocretin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33073", "l": "2-deoxy-L-scyllo-inosose + phosphate => D-glucose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004703", "l": "G protein-coupled receptor kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844620", "l": "dsDNA:AIM2 clusters bind ASC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18204", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 <=> (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31644", "l": "mycinamicin VI + S-adenosyl-L-methionine => H(+) + mycinamicin III + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36223", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + H(+) + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3782637", "l": "HDAC8 deacetylates histones (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.-", "l": "\"Transferring other groups\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29134", "l": "menaquinol-8 + nitrate <=> H2O + menaquinone-8 + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41281", "l": "octadecanoate + sphing-4-enine => H2O + N-octadecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.113", "l": "\"Alpha-1,4-glucan-protein synthase (ADP-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050305", "l": "strombine dehydrogenase activity"}, {"i": "RHEA:14061", "l": "H2O + N-(carboxymethyl)-D-alanine + NAD(+) = glycine + H(+) + NADH + pyruvate"}, {"i": "EC:1.5.1.22", "l": "\"Strombine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391936", "l": "EP1 receptor can bind PGE2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805126", "l": "AURKB phosphorylates TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40512", "l": "2,3-dihydroxypropane-1-sulfonate + NAD(+) => 3-sulfolactaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381608", "l": "cAMP activates EPAC2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050212", "l": "progesterone 11-alpha-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371422", "l": "ATP hydrolysis by HSP70 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851979", "l": "BTNL9 binds immune cell surfaces (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944706", "l": "miR-21 nonendonucleolytic RISC binds PTEN mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51078", "l": "2-hydroxy-17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+) => 2-hydroxy-17beta-estradiol + 3'-phosphoadenylyl sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21841", "l": "N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928654", "l": "Clathrin internalises EPH:EFN complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624131", "l": "UNC119B binds myristoylated proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32849", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39985", "l": "2 [Fe(III)-cytochrome b5] + a 2-hydroxy fatty acid + H2O => 2 [Fe(II)-cytochrome b5] + a 1,2-saturated fatty acid + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2980720", "l": "NEK9 binds NEK6/NEK7 in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34799", "l": "2,3-didehydroadipoyl-CoA + acetyl-CoA = 3-oxo-5,6-didehydrosuberyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-984606", "l": "Kinesin-5 is a homotetramer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66201", "l": "O2 + pentanoyl-CoA => (2E)-pentenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31132", "l": "5,10-methenyltetrahydrofolate + H2O + N(1)-(5-phospho-beta-D-ribosyl)glycinamide => (6S)-5,6,7,8-tetrahydrofolate + 2 H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55244", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33606", "l": "H(+) + N-hexacosanoylsphinganine + NADPH + O2 <=> H2O + N-(2-hydroxyhexacosanoyl)-sphinganine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.100", "l": "\"[Myelin-proteolipid] O-palmitoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13363", "l": "CDP-glycerol + diphosphate => CTP + H(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052727", "l": "capsanthin synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35892", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0004673", "l": "protein histidine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46366", "l": "2 [Fe(III)-cytochrome b5] + an N-acyl-(4R)-4-hydroxysphinganine + H2O => 2 [Fe(II)-cytochrome b5] + an N-acylsphinganine + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52320", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryptamine = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + serotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388808", "l": "CD28 homodimer binds B7-2 monomer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9737780", "l": "MTTP binds lomitapide (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51972", "l": "an L-polyhomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635845", "l": "GLI proteins bind CDC73 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130619", "l": "TGN-lysosomal vesicle coat assembly (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18087", "l": "coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine => coenzyme B + coenzyme M + methanophenazine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52133", "l": "adenosine-5'-diphospho-5'-(ribonucleotide)-(DNA) + H2O => 5'-phospho-(ribonucleotide)-(DNA) + AMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48640", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59393", "l": "acetyl-CoA + L-seryl-[protein] => CoA + O-acetyl-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160003", "l": "mono-ADP-D-ribose modification-dependent protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12956", "l": "ATP + L-seryl-[Goodpasture antigen-binding protein] <=> ADP + H(+) + O-phospho-L-seryl-[Goodpasture antigen-binding protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10967", "l": "ATP + D-xylulose <=> ADP + D-xylulose 5-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39460", "l": "(7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103082", "l": "2-(4'-methylthio)butylmalate synthase activity"}, {"i": "MetaCyc:RXNQT-4166"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169192", "l": "PTP1B dephosphorylates GHR (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36007", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46772", "l": "1-octadecanoyl 2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.19.28", "l": "\"sn-1 stearoyl-lipid 9-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27975", "l": "6-carboxy-5,6,7,8-tetrahydropterin + H(+) => 7-carboxy-7-deazaguanine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22334", "l": "2-methylmaleate + H2O => (3R)-citramalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63178", "l": "(2R)-ibuprofenoyl-CoA => (2S)-ibuprofenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49384", "l": "(12R)-hydroxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = (12R),18-dihydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444476", "l": "FPRL2 receptor binds a wide range of ligands (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57270", "l": "GMP + H(+) + lactate => H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16742", "l": "a 2-acylglycerol + an acyl-CoA => a 1,2-diacylglycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54368", "l": "acetaldehyde + H(+) + pyruvate = acetoin + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1237160", "l": "MTA is cleaved and phosphorylated (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009001", "l": "serine O-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981832", "l": "NMUR2 binds neuromedin-S (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211924", "l": "CYP4B1 12-hydroxylates ARA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028583", "l": "Phosphorylation of YAP by LATS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22829", "l": "1-(5-phospho-beta-D-ribosyl)-ATP + H2O => 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396029", "l": "Latent TGF-beta-3 binds integrins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-947514", "l": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9669893", "l": "KIT binds type I TKIs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37656", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031404", "l": "chloride ion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810158", "l": "HOXB3 chromatin is activated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645428", "l": "ALPK1 binds ADP-heptose (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27815", "l": "acetate(in) => acetate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41938", "l": "a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + H(+) + UDP => a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050398", "l": "wax-ester hydrolase activity"}, {"i": "RHEA:13577", "l": "a wax ester + H2O = a long chain fatty alcohol + a long-chain fatty acid + H(+)"}, {"i": "EC:3.1.1.50", "l": "\"Wax-ester hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53174", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46704", "l": "ATP + H(+) + salicylate = 2-hydroxybenzoyl-5'-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211224", "l": "Association of DFF40 with DFF45 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061486", "l": "high-affinity fructose transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14707", "l": "CoA-disulfide + H(+) + NADPH => 2 CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183052", "l": "CBL binds to GRB2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53090", "l": "2-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine => 2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40567", "l": "AH2 + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + O2 = A + dTDP-beta-L-evernitrose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11749", "l": "fluoroacetaldehyde + L-threonine => 4-fluoro-L-threonine + acetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624256", "l": "Defective SLC17A8 does not exchange cytosolic L-Glu for synaptic vesicle H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374251", "l": "DARC  is a non-specific receptor for many chemokines (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229283", "l": "LCNs bind lipids (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033728", "l": "divinyl chlorophyllide a 8-vinyl-reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109813", "l": "GRB2-1 binds SOS1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382096", "l": "Formation of NR-NCOR Corepressor Complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60031", "l": "(2E)-geranyl diphosphate + H2O <=> 4-terpineol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000074", "l": "TCII binds Cbl in the circulation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31301", "l": "2 H(+) + NADH + perillate => H2O + NAD(+) + perillyl aldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25851", "l": "(1S,5S)-carveol + NAD(+) <=> (S)-carvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39305", "l": "(2E,11Z,14Z)-eicosatrienoyl-CoA + H2O => (3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015487", "l": "melibiose:cation symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1462041", "l": "HNP1-4 are released into phagocytic vacuoles (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987007", "l": "p-STAT1 dimerizes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033977", "l": "2-haloacid dehalogenase (configuration-retaining) activity"}, {"i": "MetaCyc:3.8.1.11-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57423", "l": "NADH + 2 oxidized [cytochrome P450] <=> H(+) + NAD(+) + 2 reduced [cytochrome P450]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22288", "l": "an oligoglycosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O = an N-acyl-sphingoid base + an oligoglycosyl-(1->4)-D-glucose"}, {"i": "EC:3.2.1.123", "l": "\"Endoglycosylceramidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48815", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003979", "l": "UDP-glucose 6-dehydrogenase activity"}, {"i": "KEGG.REACTION:R00286"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30878", "l": "2-oxoglutarate + D-lysine <=> 6-amino-2-oxohexanoate + D-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40421", "l": "3,7,11,15-tetramethylhexadecanoate + CoA + H(+) => H2O + phytanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022941", "l": "MECP2 binds GAD2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33898", "l": "NAD(+) + trans,octa-cis-decaprenylphospho-beta-D-arabinofuranose <=> H(+) + NADH + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483089", "l": "PE is converted to PS by PTDSS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605052", "l": "NR1H3 mRNA is translated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2317332", "l": "PIP3 recruits AKT to the membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11820", "l": "diphthamide-[translation elongation factor 2] + NAD(+) = H(+) + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide"}, {"i": "EC:2.4.2.36", "l": "\"NAD(+)--diphthamide ADP-ribosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371353", "l": "Soluble TNF-alpha binds TNFR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51241", "l": "(9Z,12Z)-octadecadienoate + O2 => (13R)-hydroperoxy-(9Z,11E)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48339", "l": "a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose <=> a neolactoside III(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-706479", "l": "TAK1 is activated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20959", "l": "2-phenylacetate + ATP + CoA <=> AMP + diphosphate + phenylacetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62007", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc6S derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc6S derivative + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20318", "l": "L-proline + NADP(+) => 1-pyrroline-2-carboxylate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071443", "l": "tDNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26237", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (2E,6E,10E)-geranylgeraniol + diphosphate"}, {"i": "EC:3.1.7.5", "l": "\"Geranylgeranyl diphosphate diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38079", "l": "2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA = 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989749", "l": "Expression of ACOX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45153", "l": "3-hydroxy-3-(methylsulfanyl)propanoyl-CoA => 3-oxopropanoyl-CoA + methanethiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64342", "l": "4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + diphosphate => (2E,6E)-farnesyl diphosphate + 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674018", "l": "BRAP binds RAS:GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689000", "l": "AADAC deacetylates PHEN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60561", "l": "L-methionyl-[protein] + S-adenosyl-L-methionine => S-adenosyl-L-homocysteine + S-methyl-L-methionyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42704", "l": "hercynine + L-cysteine + O2 = H2O + S-(hercyn-2-yl)-L-cysteine S-oxide"}, {"i": "EC:1.14.99.51", "l": "\"Hercynylcysteine S-oxide synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21057", "l": "lactoyl-CoA => acryloyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56048", "l": "daidzein + UDP-alpha-D-glucose = daidzein 7-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446694", "l": "IRAK4 phosphorylates IRAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26116", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + epi-cedrol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31564", "l": "H2O + leukotriene C4 => L-glutamate + leukotriene D4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33969", "l": "3-maleylpyruvate + H(+) => 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9646685", "l": "Aggresome dissociates from dynein and microtubule (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610752", "l": "GLI3R translocates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604731", "l": "Autocatalytic activation of MMP3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19730", "l": "acetoacetate + H(+) => acetone + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66232", "l": "IC-asc-C7-CoA + O2 = H2O2 + IC-asc-DeltaC7-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042281", "l": "dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014467", "l": "RHOG binds effectors at the ER membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31823", "l": "(2E,6E)-farnesyl diphosphate + H2O = cubebol + diphosphate"}, {"i": "EC:4.2.3.91", "l": "\"Cubebol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814831", "l": "TBC1D20 binds RAB1:GTP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168894", "l": "p-STAT5A/B dissociates from the Growth Hormone receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66522", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047136", "l": "4-(dimethylamino)phenylazoxybenzene reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33652", "l": "(9Z,12Z)-octadecadienoate + ATP + CoA => (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373730", "l": "Neurofascin and NrCAM heterodimerization (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674140", "l": "PAQR3 binds inactive RAFs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665989", "l": "DIAPH1 binds RHOA:GTP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50476", "l": "anthraniloyl-CoA + L-cysteinyl-[PqsD protein] = CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004879", "l": "nuclear receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44234", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49987", "l": "H(+) + jasmonate + NADPH + O2 <=> (1R,2R)-12-hydroxyjasmonate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63802", "l": "GDP-beta-L-gulose => GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31751", "l": "chlorophyllide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = 7(1)-hydroxychlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12312", "l": "dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2 = 2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+)"}, {"i": "EC:1.14.14.22", "l": "\"Dibenzothiophene sulfone monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607757", "l": "K63polyUb-TRAF6 ubiquitinates TAK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354060", "l": "Translocation of RIAM to plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0052834", "l": "inositol monophosphate phosphatase activity"}, {"i": "MetaCyc:RXN-10949"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22136", "l": "7(1)-hydroxychlorophyllide a + H(+) + NADPH + O2 = chlorophyllide b + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5622134", "l": "CRABP1 binds atRA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24216", "l": "(2E,6E)-farnesal + H2O + NAD(+) = (2E,6E)-farnesoate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.94", "l": "\"Farnesal dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782943", "l": "UV-DDB ubiquitinates XPC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090409", "l": "malonyl-CoA synthetase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788611", "l": "HYKK phosphorylates 5HLYS (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265428", "l": "Interaction of integrin alpha9beta1 with VCAM1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39905", "l": "3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate + H(+) => isoxazolin-5-one + O-acetyl-L-serine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008674", "l": "2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168312", "l": "Fusion of the influenza virion HA2 protein transmembrane domain to the host cell endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34844", "l": "7,8-dihydromonapterin 3'-triphosphate + 3 H2O => 7,8-dihydromonapterin + 2 H(+) + 3 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53898", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc-R + CMP + H(+) => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56512", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O = 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29730", "l": "ethane-1-sulfonate + FMNH2 + O2 <=> acetaldehyde + FMN + 2 H(+) + H2O + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55479", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + N-acyleicosasphinganine + O2 <=> 2 [Fe(III)-cytochrome b5] + H2O + N-acyl-4-hydroxyeicosasphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9656891", "l": "OPN1SW binds 11cRAL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035299", "l": "inositol pentakisphosphate 2-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10225", "l": "ATP + pyridoxal => ADP + H(+) + pyridoxal 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43449", "l": "H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11665", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + CMP-N-acetyl-beta-neuraminate => 1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27884", "l": "3'-CMP + H(+) => 2',3'-cyclic CMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877348", "l": "RUNX1, FOXP3 and NFATC2 bind the IL2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61685", "l": "glycero-2-phosphocholine + H2O => glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17582", "l": "an N-carbamoyl-L-2-amino acid + 2 H(+) + H2O => an L-alpha-amino acid + CO2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11868", "l": "D-arabinitol + NADP(+) = D-ribulose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51498", "l": "a sphingoid 1-phosphate + ADP + H(+) => a sphingoid base + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38361", "l": "thiosulfate + ubiquinol-10 => 2 H(+) + hydrogen sulfide + sulfite + ubiquinone-10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854736", "l": "FLT3LG dimer:FLT3 binds FLT3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442862", "l": "Nuclear export of  p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.147", "l": "\"Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25343", "l": "H2O + urea => carbamate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60986", "l": "16-oxohexadecanoate + H(+) + NADH => 16-hydroxyhexadecanoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-378952", "l": "Thyrotropin is a heterodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31865", "l": "friedelin => (S)-2,3-epoxysqualene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5263633", "l": "DYSF, CAV3 and TRIM72 bind (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16002", "l": "H(+) + H2O + N(6)-methyl-AMP => IMP + methylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63267", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + O2 <=> 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162914", "l": "Myristoylation of Nef (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-947531", "l": "Molybdenum ion transfer onto molybdopterin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31317", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP + H(+) => (2R)-3-phosphoglycerate + GDP-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43780", "l": "2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]"}, {"i": "EC:1.3.8.5", "l": "\"Short-chain 2-methylacyl-CoA dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399952", "l": "Phosphorylation of LIMK-1 by PAK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38670", "l": "sphing-4-enine 1-phosphate(in) <=> sphing-4-enine 1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047070", "l": "3-carboxyethylcatechol 2,3-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19765", "l": "glycerol = 3-hydroxypropanal + H2O"}, {"i": "EC:4.2.1.30", "l": "\"Glycerol dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782820", "l": "USP17 deubiquitinates SUDS3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352927", "l": "dihydroxyacetone phosphate <=> glyceraldehyde 3-phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18160", "l": "ATP + pyruvate <=> ADP + H(+) + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30696", "l": "3-aminopropanal + H2O + NAD(+) => beta-alanine + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50486", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41360", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = H(+) + hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36313", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADH => 3,4-dihydroxybenzaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62844", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-fucose = beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-D-glucosamine + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664850", "l": "ATM binds PEX5 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56758", "l": "4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => 5 H(+) + 3 O2 + obtusifoliol + 6 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27808", "l": "acetate + acetoacetyl-CoA => acetoacetate + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102236", "l": "trans-4-hexen-3-one reductase activity"}, {"i": "MetaCyc:RXN-12296"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60471", "l": "3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) <=> 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627056", "l": "Procaspase 9 forms dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19935", "l": "D-glucose + phosphate => alpha-D-glucose 1-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70596", "l": "GOT2 dimer deaminates L-Asp (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25820", "l": "H2O + O2 + spermidine = 4-aminobutanal + H2O2 + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714691", "l": "RAC3 binds ER effectors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65912", "l": "3-hydroxy-L-kynurenine + pyruvate = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23705", "l": "GTP + 3 H2O => 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12779", "l": "2-amino-4,7-dihydroxypteridine + chemical entity => 2-amino-4-hydroxypteridine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214405", "l": "Assembly of the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23805", "l": "N-acetyl-alpha-D-glucosamine 1-phosphate => N-acetyl-D-glucosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679045", "l": "C-ter TLR9 dimer binds HCQ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44864", "l": "a triacyl-sn-glycerol + H2O = a 1,2-diacylglycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380294", "l": "Loss of C-Nap-1 from centrosomes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112755", "l": "SOCS3 binds IL6ST (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016217", "l": "N-ethylammeline chlorohydrolase activity"}, {"i": "MetaCyc:R465-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0015216", "l": "purine nucleotide transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445064", "l": "Activation of Rac1 by VAV2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264865", "l": "Caspase-mediated cleavage of Lamin A (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21541", "l": "N-(5-phospho-beta-D-ribosyl)anthranilate => 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42855", "l": "3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine <=> (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036222", "l": "XTP diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9619376", "l": "CAMK1 binds calmodulin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48559", "l": "4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) <=> 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953111", "l": "E2F6 binds TFDP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0101014", "l": "[isocitrate dehydrogenase (NADP+)] phosphatase activity"}, {"i": "MetaCyc:ICITDEHASE-KIN-PHOSPHA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31183", "l": "acetyl-CoA + decanoyl-CoA = 3-oxododecanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32358", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + 2 UDP-alpha-D-glucose <=> 2 H(+) + ternatin C5 + 2 UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15338", "l": "H2O + phenylglyoxylyl-CoA => CoA + H(+) + phenylglyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65167", "l": "benzoyl-CoA + hexan-3-ol <=> CoA + hexan-3-yl benzoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-434650", "l": "MATEs mediate extrusion of xenobiotics (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47362", "l": "an aliphatic alcohol + decanoate + H(+) => decanoate ester + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59441", "l": "(-)-dehydrodiconiferyl alcohol + H(+) + NADPH => (S)-isodihydrodehydrodiconiferyl alcohol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852200", "l": "Inactivation of LCK by PTPN22 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35616", "l": "hydroxyacetone + NAD(+) => H(+) + methylglyoxal + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2168046", "l": "Collagen type XII degradation by MMP12 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37681", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0032549", "l": "ribonucleoside binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.10.2", "l": "\"Non-specific protein-tyrosine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21789", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990930", "l": "mRNA N1-methyladenosine dioxygenase activity"}, {"i": "RHEA:49516", "l": "2-oxoglutarate + N(1)-methyladenosine in mRNA + O2 = adenosine in mRNA + CO2 + formaldehyde + succinate"}, {"i": "EC:1.14.11.54", "l": "\"mRNA N(1)-methyladenine demethylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47878", "l": "ganglioside GM1 + N-acetylneuraminate => ganglioside GD1b + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36546", "l": "H2O + mycothiol S-conjugate <=> 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58687", "l": "FAD + 2 H(+) + NADPH + O2 <=> FADH2-C4alpha-hydroperoxide + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23835", "l": "an N-acyl-D-mannosamine + ATP <=> ADP + an N-acyl-D-mannosamine 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851352", "l": "CCR8 binds CCL1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11449", "l": "NAD(+) + pregnan-21-ol => H(+) + NADH + pregnan-21-al"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.1.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674018", "l": "BRAP binds RAS:GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32160", "l": "AH2 + epoxyqueuosine(34) in tRNA => A + H2O + queuosine(34) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607740", "l": "PKC-delta phosphorylates CARD9 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21250", "l": "diphosphate + RNA(n+1) => a ribonucleoside 5'-triphosphate + RNA(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53923", "l": "ATP + L-threonyl-[Fas-activated protein] <=> ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15250", "l": "3,4,5-trihydroxybenzoate + UDP-alpha-D-glucose => 1-O-galloyl-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0035014", "l": "phosphatidylinositol 3-kinase regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66141", "l": "acetyl-CoA + octopamine => CoA + H(+) + N-acetyloctopamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12952", "l": "D-fuconate <=> 2-dehydro-3-deoxy-D-fuconate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42215", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O <=> a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45891", "l": "12-methyltridecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(11-methyldodecyl)-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29144", "l": "a ubiquinol + 2 H(+)(in) + nitrate => a ubiquinone + 2 H(+)(out) + H2O + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59336", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene + A = AH2 + demethylspheroidene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47632", "l": "H2O + L-arginine + NAD(+) = 5-guanidino-2-oxopentanoate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60486", "l": "cyclic CMP-UMP + 2 diphosphate => CTP + UTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013158", "l": "CDC42 GDIs block activation of CDC42 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33564", "l": "(4R)-hydroxysphinganine + ATP => (4R)-hydroxysphinganine 1-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655247", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15699", "l": "2 H(+) + H2O + licodione + oxidized [NADPH--hemoprotein reductase] => liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210881", "l": "Dimerization of Tie2/Ang1 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052920", "l": "(2R)-2-hydroxy-2-methylbutanenitrile lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671737", "l": "p-T774-PKN1 binds CDC25C (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876789", "l": "CARNMT1 methylates CARN to Anserine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688797", "l": "ATXN3 family cleave Ub chains (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167181", "l": "Addition of nucleotides leads to HIV-1 transcript elongation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042945", "l": "D-serine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10306", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP] => a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22663", "l": "a fatty acid + ATP + holo-[ACP] <=> a fatty acyl-[ACP] + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5626549", "l": "IQGAPs bind CALM1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16619", "l": "alpha-D-glucose 1-phosphate + D-glucose => beta-D-glucosyl-(1->3)-D-glucose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10833", "l": "a 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O => 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0062105", "l": "RNA 2'-O-methyltransferase activity"}, {"i": "RHEA:58956", "l": "a ribonucleotide in RNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in RNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51914", "l": "(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632649", "l": "Hh-Npp binds GAS1 and PTCH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25260", "l": "N-acetyl-D-glucosamine 6-phosphate <=> N-acetyl-D-mannosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52190", "l": "(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O => 1-aci-nitro-2-(1H-indol-3-yl)ethane + glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928645", "l": "EPHB:NMDAR binds TIAM1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19681", "l": "ATP + biotin + CoA = AMP + biotinyl-CoA + diphosphate"}, {"i": "EC:6.2.1.11", "l": "\"Biotin--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43200", "l": "cytidine(1920) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1920) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.226", "l": "\"23S rRNA (cytidine(1920)-2'-O)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66122", "l": "(2S)-2-aminobutanoate + 4-methylsulfanyl-2-oxobutanoate => 2-oxobutanoate + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707594", "l": "Hemes bind LY96 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.10"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050029", "l": "L-lysine oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64904", "l": "GTP + 2 H2O = GMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047778", "l": "[citrate-(pro-3S)-lyase] thiolesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046421", "l": "methylisocitrate lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48787", "l": "D-erythrulose 4-phosphate <=> D-erythrose 4-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004751", "l": "ribose-5-phosphate isomerase activity"}, {"i": "REACT:R-HSA-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51956", "l": "(E)-2-methylpropanal oxime = (Z)-2-methylpropanal oxime"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63936", "l": "3 a ubiquinone + protoporphyrinogen IX = 3 a ubiquinol + protoporphyrin IX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.100", "l": "\"Mannan 1,4-mannobiosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49382", "l": "5,20-dihydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63984", "l": "5-hydroxyuridine + ATP = 5-hydroxyuridine 5'-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44081", "l": "ATP + CoA + undecanoate => AMP + diphosphate + undecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57439", "l": "guaethol + O2 + reduced [NADH--hemoprotein reductase] <=> acetaldehyde + catechol + H(+) + H2O + oxidized [NADH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9690449", "l": "S1PR1 bind S1P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55144", "l": "[(3S,4R)-4-(6-methylheptanoyl)-5-oxooxolan-3-yl]methyl phosphate + NADP(+) = [4-(6-methylheptanoyl)-5-oxo-2H-furan-3-yl]methyl phosphate + H(+) + NADPH"}, {"i": "RHEA:55148", "l": "a [(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP(+) = a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + H(+) + NADPH"}, {"i": "EC:1.3.1.113", "l": "\"(4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12263", "l": "ATP + NADH <=> ADP + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2002428", "l": "Removal of fibrillar collagen N-propeptides (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39516", "l": "(2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH => (15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204364", "l": "ROBO1 binds SLIT2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534040", "l": "Unknown NAT N-acylates Gly in GNAT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912416", "l": "NOTCH1 gene transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873921", "l": "Binding of STAT1 to p-IFNGR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57885", "l": "diphosphate + H2O + Na(+)(in) => H(+) + Na(+)(out) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49843", "l": "(-)-dehydrodiconiferyl acid + 2 a quinone + H2O <=> (-)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804276", "l": "ATM phosphorylates TTC5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797553", "l": "Protein 4.1 binds CASK (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610732", "l": "GSK3 phosphorylates p-GLI3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49423", "l": "ATP + valienone <=> ADP + H(+) + valienone 7-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50682", "l": "N-terminal L-glutamyl-[protein] + NH4(+) => H2O + N-terminal L-glutaminyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27371", "l": "acetaldehyde + acetyl-CoA + H(+) + NADH => acetoin + CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48144", "l": "H2O + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-(octadecanoyl)-sphing-4-enine = ganglioside GT1b (d18:1(4E)/18:0) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211219", "l": "Translocation of caspase-3 to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53052", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate = 4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15512", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1169406", "l": "ISGylation of host proteins (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692781", "l": "p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5213466", "l": "RIPK3 is phosphorylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69142", "l": "Recruitment of Dna2 endonuclease (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34045", "l": "5''-phosphoribostamycin + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + neamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19727", "l": "CO2 + UDP-beta-L-arabinopyranose => H(+) + UDP-alpha-D-galacturonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49894", "l": "(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2 => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38587", "l": "UDP-alpha-D-glucose + vancomycin aglycone = devancoaminyl-vancomycin + UDP"}, {"i": "EC:2.4.1.310", "l": "\"Vancomycin aglycone glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14388", "l": "dolichyl diphosphate + H2O <=> dolichyl phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008748", "l": "N-ethylmaleimide reductase activity"}, {"i": "RHEA:35523", "l": "H(+) + N-ethylmaleimide + NADPH = N-ethylsuccinimide + NADP(+)"}, {"i": "MetaCyc:RXN0-5101"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430201", "l": "p-SLP-76:ADAP binds Ena/VASP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.43", "l": "\"Carboxynorspermidine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661726", "l": "An unknown reductase reduces D-UBGN to STBN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008693", "l": "3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050597", "l": "taxane 10-beta-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030745", "l": "dimethylhistidine N-methyltransferase activity"}, {"i": "MetaCyc:2.1.1.44-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50393", "l": "H(+) + oxidized coenzyme F420-(gamma-Glu)(n) + oxytetracycline => 5a,11a-dehydrooxytetracycline + reduced coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36726", "l": "2-phenylethylamine + A + H2O <=> 2-phenylacetaldehyde + AH2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804724", "l": "MDM2 ubiquitinates phosphorylated MDM4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63830", "l": "pyruvate + vanillylamine => L-alanine + vanillin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354066", "l": "Translocation of PTK2 to Focal complexes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610026", "l": "Defective GALK1 does not phosphorylate Gal (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662818", "l": "iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66792", "l": "N-methyl-D-dopa + O2 = (3R)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22583", "l": "(S)-4-hydroxy-2-oxopentanoate <=> (2Z)-2-hydroxypenta-2,4-dienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48765", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD(+) => 3-acetyl-3-devinylchlorophyllide a + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49262", "l": "D-galactose 6-phosphate(in) + L-histidyl-[protein] => D-galactose(out) + N(pros)-phospho-L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008673", "l": "2-dehydro-3-deoxygluconokinase activity"}, {"i": "MetaCyc:DEOXYGLUCONOKIN-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31563", "l": "H2O + leukotriene C4 = L-glutamate + leukotriene D4"}, {"i": "EC:3.4.19.14", "l": "\"Leukotriene-C(4) hydrolase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034027", "l": "(carboxyethyl)arginine beta-lactam-synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5195402", "l": "CDK1 phosphorylates LPIN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730884", "l": "Phosphorylation of NTAL by p-SYK/Lyn (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964252", "l": "G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801101", "l": "RABGGTA binds RABGGTB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008281", "l": "sulfonylurea receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39559", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA = (2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31390", "l": "(S)-2,3-epoxysqualene <=> alpha-amyrin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399966", "l": "AKT1 E17K mutant phosphorylates GSK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39909", "l": "dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + L-glutamate => 2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168885", "l": "Haptoglobin binds Hemoglobin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51834", "l": "AMP(in) + diphosphate(in) + H(+)(in) + tetracosanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + tetracosanoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48424", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H2O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dUMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.-.-", "l": "\"Intramolecular lyases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605724", "l": "Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63496", "l": "4-nitrobenzaldehyde + H(+) + NADPH = 4-nitrobenzyl alcohol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031419", "l": "cobalamin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21324", "l": "2 H(+) + reduced [rubredoxin] + superoxide = H2O2 + oxidized [rubredoxin]"}, {"i": "EC:1.15.1.2", "l": "\"Superoxide reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24185", "l": "4,5-dihydroxyphthalate + H(+) => 3,4-dihydroxybenzoate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.102", "l": "\"Phenacrylate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625426", "l": "Retrograde IFT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62561", "l": "(4R)-limonene + A + H2O => (4R)-perillyl alcohol + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871265", "l": "YAP1 binds TEAD4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34548", "l": "ATP + cob(II)yrinate + H2O + L-glutamine => ADP + cob(II)yrinate c monoamide + H(+) + L-glutamate + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099521", "l": "ATPase coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42412", "l": "(2R)-2,3-bisphosphoglycerate + ATP + H(+) = ADP + cyclic (2R)-2,3-bisphosphoglycerate + phosphate"}, {"i": "EC:6.5.1.9", "l": "\"Cyclic 2,3-diphosphoglycerate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874789", "l": "TFAP2C homodimer binds the EGFR gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662708", "l": "CREB binds IL6 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213210", "l": "Collagen IX is cross-linked to the surface of collagen type II fibrils (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74726", "l": "Dissociation of insulin from insulin receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102912", "l": "(-)-lactol dehydrogenase activity"}, {"i": "MetaCyc:RXN-8681"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56509", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9687625", "l": "ATP binds MLKL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033942", "l": "4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64274", "l": "benzaldehyde + L-alanine => benzylamine + pyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0016673", "l": "oxidoreductase activity, acting on a sulfur group of donors, iron-sulfur protein as acceptor"}, {"i": "EC:1.8.7.-", "l": "\"With an iron-sulfur protein as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034001", "l": "chondroitin-sulfate-ABC exolyase activity"}, {"i": "MetaCyc:4.2.2.21-RXN"}, {"i": "EC:4.2.2.21", "l": "\"Chondroitin-sulfate-ABC exolyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727819", "l": "TAK1 phosphorylates MKK6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36349", "l": "4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine => N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18232", "l": "glycolate + NAD(+) <=> glyoxylate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467761", "l": "A2E is phagocytosed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2250301", "l": "Formation of lysyl-pyrrole cross-links (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683801", "l": "CHEK2 phosphorylates BRCA1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009045", "l": "xylose isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62770", "l": "4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O => 4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52301", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5323526", "l": "FRAT proteins bind GSK3beta (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37431", "l": "12,18-didecarboxysiroheme + 2 AH2 + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + 2 A + 2 acetate + Fe-coproporphyrin III + 2 H(+) + 2 L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31655", "l": "4-deoxy-Delta(4)-beta-D-GlcpA2S-(1->3)-beta-D-GalpNAc + H2O = 5-dehydro-4-deoxy-2-O-sulfo-D-glucuronate + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693598", "l": "ATM phosphorylates NBN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64124", "l": "H2O + N-hexadecanoyl-L-phenylalanine = hexadecanoate + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9681375", "l": "KIT binds ripretinib (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032560", "l": "guanyl deoxyribonucleotide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37483", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-dodecanoyl-sn-glycero-3-phosphocholine = 1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55101", "l": "3-oxopentanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxypentanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44362", "l": "3-hydroxy-2,4-dioxopentyl phosphate => (2S)-2-hydroxy-3,4-dioxopentyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55698", "l": "an N-acyl-sphingoid base + H(+) + mannosylinositol-1-phosphate => a mannosylinositol-1-phospho-N-acyl-sphingoid base + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16447", "l": "daidzein + H(+) + H2O => (2R,3S)-2,4',7-trihydroxyisoflavanone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12563", "l": "hydroquinone + UDP-alpha-D-glucose <=> H(+) + hydroquinone O-beta-D-glucopyranoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31424", "l": "(2Z,6E)-farnesyl diphosphate => (-)-alpha-cedrene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212222", "l": "PRC2 recruits DNA methyltransferases (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73932", "l": "Resynthesis of excised residue by POLB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50278", "l": "(12S)-hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030780", "l": "12-hydroxydihydrochelirubine 12-O-methyltransferase activity"}, {"i": "RHEA:21092", "l": "12-hydroxydihydrochelirubine + S-adenosyl-L-methionine = dihydromacarpine + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.120", "l": "\"12-hydroxydihydrochelirubine 12-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44903", "l": "D-galactono-1,4-lactone + H2O <=> D-galactonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352908", "l": "fructose 6-phosphate + ATP => fructose 2,6-bisphosphate + ADP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22471", "l": "GTP + 3 H2O <=> 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55733", "l": "19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] => 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12424", "l": "(3S)-3-hydroxy-L-aspartate = NH4(+) + oxaloacetate"}, {"i": "EC:4.3.1.16", "l": "\"Threo-3-hydroxy-L-aspartate ammonia-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20329", "l": "ATP + L-seryl-[low-density-lipoprotein receptor] = ADP + H(+) + O-phospho-L-seryl-[low-density-lipoprotein receptor]"}, {"i": "EC:2.7.11.29", "l": "\"[Low-density-lipoprotein receptor] kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41853", "l": "H(+) + malonyl-[ACP] + octanoyl-[ACP] => 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9633044", "l": "ESR binds STRN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210444", "l": "L-Glutamate loading of synaptic vesicle (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34349", "l": "(2E)-geranial + H(+) + NADH => (2E)-geraniol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.3", "l": "\"Acyl-CoA 6-desaturase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004139", "l": "deoxyribose-phosphate aldolase activity"}, {"i": "MetaCyc:DEOXYRIBOSE-P-ALD-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32146", "l": "L-arginine(in) <=> L-arginine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878914", "l": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374337", "l": "Apelin receptor binds to apelin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62183", "l": "H2O + peregrinol diphosphate <=> diphosphate + viteagnusin D"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23002", "l": "(R)-4-dehydropantoate + H(+) + NADH => (R)-pantoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008719", "l": "dihydroneopterin triphosphate 2'-epimerase activity"}, {"i": "MetaCyc:H2NTPEPIM-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31879", "l": "(S)-2,3-epoxysqualene = beta-seco-amyrin"}, {"i": "EC:5.4.99.54", "l": "\"Beta-seco-amyrin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11696", "l": "3'-demethylstaurosporine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + staurosporine"}, {"i": "EC:2.1.1.139", "l": "\"3'-demethylstaurosporine O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "74.836269892493803", "identifiers": [{"i": "GO:0019207", "l": "kinase regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70596", "l": "GOT2 dimer deaminates L-Asp (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29464", "l": "K(+)(in) => K(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34222", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O + NAD(+) <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57073", "l": "3-oxoisoapionate 4-phosphate + H(+) => CO2 + L-erythrulose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.8", "l": "\"Hypoxanthine phosphoribosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047382", "l": "methylphosphothioglycerate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38689", "l": "(4R)-hydroxysphinganine(out) + ADP + H(+) + phosphate => (4R)-hydroxysphinganine(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977375", "l": "CR1 binds C3bBb/C4bC2a (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32004", "l": "(+)-copalyl diphosphate => diphosphate + isopimara-8(14),15-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592231", "l": "Expression of CYCS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14495", "l": "ADP-D-ribose + L-arginyl-[dinitrogen reductase] => H2O + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14218", "l": "[thioredoxin]-disulfide + H2O + L-methionyl-[protein] => [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26519", "l": "3-hydroxypropanoyl-CoA => acryloyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13176", "l": "H2O + NAD(+) + phosphonate <=> H(+) + NADH + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781899", "l": "USP13 binds SIAH2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12137", "l": "a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) => a (2E,4E)-dienoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033803", "l": "kaempferol 4'-O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44162", "l": "myo-inositol + phosphate => 1D-myo-inositol 6-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28507", "l": "alpha-Kdo-(2->6)-lipid IVA + ATP => 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052692", "l": "raffinose alpha-galactosidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017176", "l": "phosphatidylinositol N-acetylglucosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140355", "l": "cargo receptor ligand activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61944", "l": "24-methylenecholesterol + UDP-alpha-D-glucose = 24-methylene cholesteryl beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9609921", "l": "SGTA binds Tail-anchored protein (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71849", "l": "LDH tetramer reduces PYR to LACT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19662", "l": "D-mannitol 1-phosphate + NAD(+) => beta-D-fructose 6-phosphate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16325", "l": "1-phospho-alpha-D-glucuronate + H(+) + UTP = diphosphate + UDP-alpha-D-glucuronate"}, {"i": "EC:2.7.7.44", "l": "\"Glucuronate-1-phosphate uridylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60506", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+) => 1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204500", "l": "CyP60 chaperones Basigin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15695", "l": "(R)-2-hydroxy-(9Z,12Z,15Z)-octadecatrienoate + A + H2O => (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938231", "l": "RUNX1:CBFB binds CREBBP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0030611", "l": "arsenate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2981040", "l": "COLEC12:ligand is endocytosed (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14918", "l": "3 O2 + obtusifoliol + 3 reduced [NADPH--hemoprotein reductase] => 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61745", "l": "steviolbioside + UDP-alpha-D-glucose => stevioside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40730", "l": "1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid <=> a 1-acylglycerone 3-phosphate + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33038", "l": "2-oxospirilloxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> 2,2'-dioxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12828", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine <=> [thioredoxin]-dithiol + H(+) + phosphate + sarcosine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106316", "l": "nitrite reductase NADH activity"}, {"i": "RHEA:24628", "l": "2 H2O + 3 NAD(+) + NH4(+) = 5 H(+) + 3 NADH + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15634", "l": "3,4-dihydroxyphenylacetate + O2 => 2-hydroxy-5-carboxymethylmuconate semialdehyde + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372843", "l": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66580", "l": "3'-phosphoadenylyl sulfate + bisphenol A = adenosine 3',5'-bisphosphate + bisphenyl A sulfate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11550", "l": "5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+) => 5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44056", "l": "2-O-hexadecanoyl-alpha,alpha-trehalose + hexadecanoyl-CoA = 2-O,3-O-dihexadecanoyl-alpha,alpha-trehalose + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050039", "l": "lactaldehyde reductase (NADPH) activity"}, {"i": "RHEA:15885", "l": "NADP(+) + propane-1,2-diol = (S)-lactaldehyde + H(+) + NADPH"}, {"i": "EC:1.1.1.55", "l": "\"Lactaldehyde reductase (NADPH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56661", "l": "7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) => 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392064", "l": "G alpha (z) inhibits adenylate cyclase (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39122", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2 <=> (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170796", "l": "NPC transports GCK1:GKRP from cytosol to nucleoplasm (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25834", "l": "H(+) + NADH + scyllo-inosine => 1D-chiro-inositol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0001727", "l": "lipid kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174367", "l": "GCL ligates L-Glu to L-Cys (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55215", "l": "(2R)-hydroxyhexadecanoyl-CoA <=> formyl-CoA + pentadecanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8979071", "l": "KDM6B binds iron (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912401", "l": "NOTCH4 gene transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51786", "l": "deoxyhumulone + diphosphate => 4-prenylphlorisovalerophenone + dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67008", "l": "a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.56", "l": "\"mRNA (guanine-N(7))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873918", "l": "Transphosphorylation of JAK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12759", "l": "H(+) + NADPH + zeatin => dihydrozeatin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57762", "l": "C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+) => 2 (S)-methylmalonyl-CoA + 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25658", "l": "(R)-pulegone + O2 + reduced [NADPH--hemoprotein reductase] = (R)-menthofuran + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.143", "l": "\"(+)-menthofuran synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928620", "l": "PAK1 autophosphorylates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010475", "l": "galactose-1-phosphate guanylyltransferase (GDP) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10380", "l": "diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate"}, {"i": "EC:2.4.2.10", "l": "\"Orotate phosphoribosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37799", "l": "2 H(+) + 2 NADH + O2 = 2 H2O + 2 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66379", "l": "D-erythrose 4-phosphate + H2O <=> D-erythrose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30687", "l": "(4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299297", "l": "Activation of THIK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55524", "l": "H(+) + H2O + L-dopa + O2 = 3,4-dihydroxyphenylacetaldehyde + CO2 + H2O2 + NH4(+)"}, {"i": "EC:4.1.1.107", "l": "\"3,4-dihydroxyphenylacetaldehyde synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36877", "l": "3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + CO2 + CoA => (21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31728", "l": "FADH2 + O2 + styrene => (2S)-2-phenyloxirane + FAD + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391936", "l": "EP1 receptor can bind PGE2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-984733", "l": "Kinesin-3 is a dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182990", "l": "Sprouty sequesters CBL away from active EGFR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46635", "l": "7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + NADPH <=> 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55664", "l": "2 AH2 + echinenone + 2 O2 = 2 A + canthaxanthin + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418852", "l": "Caspase cleavage of UNC5B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63781", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050782", "l": "galactose uniporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61202", "l": "CoA + myricetin 3-O-[(6-O-acetyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside] => acetyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446364", "l": "Migfilin interacts with VASP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.260", "l": "\"rRNA small subunit pseudouridine methyltransferase Nep1\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15331", "l": "H(+) + N-carbamoyl-2-oxoglycine + NADH => (S)-ureidoglycolate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549129", "l": "OCT1 transports organic cations into hepatic cells (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55236", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H2O = (9Z)-octadecenoate + 1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57646", "l": "H(+) + H2O + holo-[equisetin nonaketide synthase] + trichosetin => (3-{(1R,2S,6S,8R)-2,8-dimethyl-3-[(E)-prop-1-enyl]-4,5-didehydrodecalin-2-yl}-3-oxopropanoyl)-[equisetin nonaketide synthase] + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57403", "l": "3-O-acetylpapaveroxine + H2O <=> acetate + H(+) + narcotine hemiacetal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62916", "l": "an N-terminal L-alpha-aminoacyl-[protein] + 3 S-adenosyl-L-methionine = an N-terminal trimethyl-L-alpha-aminoacyl-[protein] + 3 H(+) + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18099", "l": "H(+) + xanthine-8-carboxylate => pteridine-2,4,6,7-tetrol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389980", "l": "unfolded actin/tubulin associates with prefoldin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26524", "l": "2-methyl-trans-aconitate + H2O => (2S,3S)-2-methylcitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46735", "l": "(2R,6)-dimethylheptanoyl-CoA <=> (2S,6)-dimethylheptanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65021", "l": "L-ornithine + succinyl-CoA => CoA + H(+) + N(2)-succinyl-L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51307", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate <=> (13R)-hydroperoxy-(9Z,11E)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980074", "l": "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52788", "l": "chlorophyll a + 2 H(+) = Mg(2+) + pheophytin a"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190263", "l": "FGFR3b binds to FGF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59554", "l": "H2O2 + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone => N,N',N'',N'''-tetraacetylchitotetraose + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19454", "l": "2-oxoglutarate + L-alanine => L-glutamate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46383", "l": "7alpha-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66413", "l": "ATP + glutathione(in) + H2O + taurochenodeoxycholate(in) => ADP + glutathione(out) + H(+) + phosphate + taurochenodeoxycholate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47394", "l": "an aliphatic alcohol + H(+) + hexadecanoate => H2O + hexadecanoate ester"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015451", "l": "decarboxylation-driven active transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43562", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34008", "l": "cholesta-5,7,24-trien-3beta-ol + S-adenosyl-L-methionine => ergosta-5,7,24(28)-trien-3beta-ol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1031716", "l": "Expression of IFNG-stimulated genes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139941", "l": "Binding of IP3 to IP3 receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33802", "l": "L-histidinol + NAD(+) <=> H(+) + L-histidinal + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5334794", "l": "FABPs bind LCFAs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610720", "l": "PKA phosphorylates GLI3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60002", "l": "formate + 2 H(+) + phosphate => hydroxymethylphosphonate + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050477", "l": "acyl-lysine deacylase activity"}, {"i": "RHEA:24548", "l": "an N(6)-acyl-L-lysine + H2O = a carboxylate + L-lysine"}, {"i": "EC:3.5.1.17", "l": "\"Acyl-lysine deacylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0071714", "l": "icosanoid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004593", "l": "pantothenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34130", "l": "(2E)-geranyl diphosphate + olivetolate <=> cannabigerolate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227778", "l": "MEKK1 binds TRAF6  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13175", "l": "H(+) + NADH + phosphate => H2O + NAD(+) + phosphonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034796", "l": "Activated NTRK3 binds PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51628", "l": "formate + H(+) + UTP = CO2 + dUTP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63705", "l": "mycophenolate + UDP-alpha-D-glucuronate => H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1629787", "l": "Synthesis of Cx26 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57415", "l": "AMP + diphosphate + L-tyrosinal + NADP(+) <=> ATP + H(+) + L-tyrosine + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781905", "l": "ZRANB1 binds APC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697043", "l": "Protease binds protease inhibitors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12851", "l": "L-seryl-[myosin light chain] + phosphate => H2O + O-phospho-L-seryl-[myosin light chain]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27604", "l": "di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate => (2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009282", "l": "CDK1 phosphorylates RUNX2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112429", "l": "Formation of FACT complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194678", "l": "CYP51A1 demethylates LNSOL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6813749", "l": "ALDH1A1 oxidises GA to DGA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18737", "l": "ATP + H2O + hydrogenselenide = AMP + 2 H(+) + phosphate + selenophosphate"}, {"i": "EC:2.7.9.3", "l": "\"Selenide, water dikinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.55", "l": "\"Venombin AB\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023460", "l": "Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683735", "l": "CHEK2 is recruited to DNA DSBs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090471", "l": "9,15,9'-tri-cis-zeta-carotene isomerase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018600", "l": "alpha-pinene dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140806", "l": "SERPINC1 binds SERPINC1 activators (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27649", "l": "inosine + phosphate <=> alpha-D-ribose 1-phosphate + hypoxanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5226999", "l": "ADD1:ADD3 binds DMTN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54987", "l": "a ubiquinol <=> a ubiquinone + 2 e(-) + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48996", "l": "3-methylcatechol + O2 = 2-hydroxy-6-oxo-2,4-heptadienoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50277", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 => (12S)-hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17163", "l": "2-oxopent-4-enoate + benzoate + H(+) => 2,6-dioxo-6-phenylhexa-3-enoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.5", "l": "\"ABC-type lipopolysaccharide transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605632", "l": "Both hexosaminidase A and B can cleave GalNAc from globoside (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48082", "l": "ferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => abieta-8,11,13-triene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168951", "l": "TLR1:TLR2 is recruited to ligand:CD14 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785898", "l": "IL4R binds JAK2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.36"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41934", "l": "H(+) + hexadecanoate + holo-[ACP] => H2O + hexadecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45415", "l": "H2O + prostaglandin D2-1-glycerol ester <=> glycerol + H(+) + prostaglandin D2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51215", "l": "(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) <=> 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17063", "l": "catechol + H2O + NADP(+) => H(+) + NADPH + O2 + phenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31629", "l": "10-deoxymethymycin + dTDP + H(+) => 10-deoxymethynolide + dTDP-alpha-D-desosamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008013", "l": "beta-catenin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65114", "l": "aculene C + CO2 + H2O + succinate => 2-oxoglutarate + aculene D + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38454", "l": "hydrogen sulfide + NADP(+) + n sulfur <=> NADPH + (n+1) sulfur"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35985", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53717", "l": "H(+) + N-acetyl-alpha-D-muramate 1-phosphate + UDP => phosphate + UDP-N-acetyl-alpha-D-muramate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16407", "l": "benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH => benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10149", "l": "blasticidin S + H(+) + H2O => deaminohydroxyblasticidin S + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0140666", "l": "annealing activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64468", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NADP(+) = 4-methylsulfanyl-2-oxobutanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5671702", "l": "AP1G2 binds HGS and CHMP2A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9017491", "l": "RHOJ GEFs activate RHOJ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33633", "l": "AMP + diphosphate + octanoyl-CoA => ATP + CoA + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75240", "l": "TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8   (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49889", "l": "(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2 => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51410", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937034", "l": "IRAK1 phosphorylates Pellino (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047214", "l": "cyanidin-3-rhamnosylglucoside 5-O-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12034", "l": "3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+) => a 3-(acyloxy)acyl derivative of bacterial toxin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158849", "l": "Phenol can form a sulfate conjugate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38151", "l": "carbonyl sulfide + H2O = CO2 + H(+) + hydrogen sulfide"}, {"i": "EC:3.13.1.7", "l": "\"Carbonyl sulfide hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10866", "l": "2-(acetamidomethylene)succinate + NADP(+) => 3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110236", "l": "OGG1 glycosylase mediated recognition and binding of a formamidopyrimidine (FapyG) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8873850", "l": "STARD5 binds DCA, LCA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34006", "l": "5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH + O2 <=> cholesta-5,7,24-trien-3beta-ol + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072585", "l": "xanthosine nucleotidase activity"}, {"i": "RHEA:27994", "l": "H2O + xanthosine = D-ribose + xanthine"}, {"i": "MetaCyc:RXN0-363"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46814", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4,4-dimethyl-8,14-cholestadien-3beta-ol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57827", "l": "dAMP + H2O <=> 2-deoxy-D-ribose 5-phosphate + adenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48324", "l": "ganglioside GD1b + GDP-beta-L-fucose = ganglioside Fuc-GD1b + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928607", "l": "p-EPHs bind VAV2,3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.33", "l": "\"Polynucleotide 5'-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391942", "l": "IP receptor can bind prostacyclin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035612", "l": "AP-2 adaptor complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36746", "l": "heptadecasphing-4-enine + tetracosenoyl-CoA <=> CoA + H(+) + N-tetracosenoyl-heptadecasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-350869", "l": "Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33288", "l": "A + spermidine => 1-pyrroline + AH2 + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016964", "l": "alpha-2 macroglobulin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65029", "l": "(+)-pinoresinol + H2O + 2 oxidized [azurin] => (+)-6-hydroxypinoresinol + 2 H(+) + 2 reduced [azurin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46589", "l": "calciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => calcidiol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-378975", "l": "Follitropin is a heterodimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2160874", "l": "HYAL1 hydrolyses (HA)50 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875183", "l": "CBL monoubiquitinates activated MET (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944242", "l": "Association of procollagen type XXVII (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57641", "l": "14 H(+) + holo-[equisetin nonaketide synthase] + 8 malonyl-CoA + 8 NADPH + 2 S-adenosyl-L-methionine => (3-{(1R,2S,6S,8R)-2,8-dimethyl-3-[(E)-prop-1-enyl]-4,5-didehydrodecalin-2-yl}-3-oxopropanoyl)-[equisetin nonaketide synthase] + 8 CO2 + 8 CoA + 6 H2O + 8 NADP(+) + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14379", "l": "glycine + glyoxylate => (3R)-3-hydroxy-L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13372", "l": "dimethylallyl diphosphate <=> diphosphate + isoprene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102512", "l": "delphinidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity"}, {"i": "MetaCyc:RXN-14441"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11180", "l": "ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)"}, {"i": "EC:6.1.1.22", "l": "\"Asparagine--tRNA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66207", "l": "heptanoyl-CoA + O2 <=> (2E)-heptenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-873927", "l": "Release of STAT1 dimer from active receptor unit (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48127", "l": "ganglioside GD3 (d18:1(4E)) + H2O <=> ganglioside GM3 (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180622", "l": "Vpr binds nucleoporins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190065", "l": "Activated TrkA receptor internalizes to endosomes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614544", "l": "Sulfite is oxidized to sulfate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31251", "l": "(S)-3-hydroxyisobutanoyl-CoA + H2O = (S)-3-hydroxy-2-methylpropanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40629", "l": "2,3-dihexadecanoyl-sn-glycerol + H(+) + hexadecanoate => H2O + trihexadecanoylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49261", "l": "D-galactose(out) + N(pros)-phospho-L-histidyl-[protein] => D-galactose 6-phosphate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381109", "l": "IRE1 binds IRE1 forming dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159796", "l": "Furin cleaves pro-factor IX to factor IX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46185", "l": "ATP + CoA + isovalerate => 3-methylbutanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57216", "l": "dGTP + glyoxal = N(2)-(1-hydroxy-2-oxoethyl)-dGTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008551", "l": "P-type cadmium transporter activity"}, {"i": "EC:7.2.2.21", "l": "\"Cd(2+)-exporting ATPase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425861", "l": "Activation of Protein Kinase C novel isoforms (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71825", "l": "G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.16"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12969", "l": "a sn-glycero-3-phosphoester + H2O = an alcohol + H(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31431", "l": "(2E,6E)-farnesyl diphosphate = (-)-beta-santalene + diphosphate"}, {"i": "EC:4.2.3.83", "l": "\"Beta-santalene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429683", "l": "CERT:ceramide [ER] => ceramide [Golgi] + CERT [ER] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29784", "l": "ATP + H2O + L-cysteine(in) => ADP + H(+) + L-cysteine(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36356", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine => 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19968", "l": "S,S-dimethyl-beta-propiothetin <=> acrylate + dimethyl sulfide + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29989", "l": "adenosine(out) + H(+)(out) => adenosine(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11409", "l": "H(+) + H2O + riboflavin => lumichrome + ribitol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015528", "l": "lactose:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140068", "l": "histone crotonyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8954056", "l": "E2F6 binds TFDP2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30018", "l": "alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose <=> alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "81.790986234327661", "identifiers": [{"i": "GO:0019208", "l": "phosphatase regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30517", "l": "H(+) + S-methyl-5'-thioadenosine + thermospermine => S-adenosyl 3-(methylsulfanyl)propylamine + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24516", "l": "acetyl-CoA + gentamicin C1a = CoA + H(+) + N(2')-acetylgentamicin C1a"}, {"i": "EC:2.3.1.59", "l": "\"Gentamicin 2'-N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48496", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + UDP-alpha-D-galactose = 1-(9Z-octadecenoyl)-2-hexadecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36913", "l": "3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoA => (13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64916", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018694", "l": "p-cymene methyl hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74723", "l": "Endosome acidification (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008859", "l": "exoribonuclease II activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218820", "l": "Src kinases phosphorylate VAV (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693148", "l": "BCKDK phosphorylates BCKDH (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14319", "l": "H(+) + morphinone + NADH => morphine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39422", "l": "3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694737", "l": "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA (plus strand) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62509", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25651", "l": "(6R)-isopiperitenone + H(+) + NADPH => (2R,5R)-isopulegone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.3.16", "l": "\"Citrate synthase (unknown stereospecificity)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.29"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47843", "l": "[5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine <=> (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662986", "l": "MT2A binds copper (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66789", "l": "N-methyl-L-dopa + O2 => (3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647631", "l": "GSDMD (1-275) binds PIPs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507871", "l": "Aquaporins passively transport glycerol out of cells (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23711", "l": "[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate <=> [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687103", "l": "FOXO3 regulates MIR34B,C expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35597", "l": "2 H(+) + maleylacetate => benzene-1,2,4-triol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46623", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol <=> (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213244", "l": "Loading of antigenic peptides (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19979", "l": "adenosine 3',5'-bisphosphate + H(+) + L-tyrosine methyl ester 4-sulfate => 3'-phosphoadenylyl sulfate + L-tyrosine methyl ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.n2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.2.2", "l": "\"Oxazoline synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003876", "l": "AMP deaminase activity"}, {"i": "RHEA:14777", "l": "AMP + H(+) + H2O = IMP + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51132", "l": "a purine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2-deoxy-D-ribose 5-phosphate + a purine nucleobase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202722", "l": "CD48 binds CD244 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31552", "l": "presqualene diphosphate => 15-cis-4,4'-diapophytoene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388832", "l": "PI3K binds CD28 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35940", "l": "brevianamide F + dimethylallyl diphosphate => diphosphate + tryprostatin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24046", "l": "4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+) => 3,4-dihydroxybenzoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23866", "l": "2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP => 4-CDP-2-C-methyl-D-erythritol 2-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30360", "l": "chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2 => chlorophyllide b + 3 H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52704", "l": "H2O + UMP = D-ribose 5-phosphate + uracil"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674567", "l": "p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164617", "l": "Elongation of Extended Telomeric Chromosome End (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350578", "l": "NQO1 interaction with ODC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57174", "l": "2-oxoglutarate + H(+) + NADH => (S)-2-hydroxyglutarate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424486", "l": "Phosphorylation and activation of VAV2/VAV3 by SYK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28866", "l": "H(+)(out) + lactose(in) <=> H(+)(in) + lactose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48442", "l": "a fatty acid + H(+) + long chain 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163798", "l": "Furin cleaves pro-protein Z to protein Z (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676133", "l": "CD74 binds MIF (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106282", "l": "isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity"}, {"i": "RHEA:42024", "l": "3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) = 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120160", "l": "intraciliary transport particle A binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3769383", "l": "CBY1 binds beta-catenin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373705", "l": "Caspase cleavage of DCC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56712", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate"}, {"i": "EC:2.5.1.145", "l": "\"Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008664", "l": "2'-5'-RNA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43580", "l": "A + D-arginine = AH2 + iminoarginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44165", "l": "ATP + H2O => adenine + D-ribose 5-triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54034", "l": "(6S)-5,6,7,8-tetrahydrofolate + dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + H(+) => (6S)-10-formyltetrahydrofolate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466706", "l": "Defective OPN1MW causes DCB and BCM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48194", "l": "(2E,9E)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (9E)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43395", "l": "1D-myo-inositol 1,3,4-trisphosphate + H2O <=> 1D-myo-inositol 1,3-bisphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57124", "l": "2-oxoglutaramate = 2-hydroxy-5-oxoproline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607740", "l": "PKC-delta phosphorylates CARD9 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30014", "l": "ATP + beta-D-galactose(out) + H2O <=> ADP + beta-D-galactose(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59285", "l": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O => D-glucose + N-octadecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19034", "l": "an N-acyl-D-glucosamine => an N-acyl-D-mannosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616110", "l": "EGR1-dependent CDK5R1 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47489", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => isodeoxycholate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31513", "l": "chenodeoxycholate + CoA + H(+) => chenodeoxycholoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59077", "l": "bis(myo-inositol) 1,3'-phosphate + 2 GDP-alpha-D-mannose => 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + 2 GDP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22407", "l": "beta-D-galacturonate + NAD(+) <=> D-galactaro-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40908", "l": "2 2-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49413", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-colitose => alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17184", "l": "a long-chain fatty aldehyde + FMNH2 + O2 <=> a long-chain fatty acid + FMN + 2 H(+) + H2O + hnu"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58340", "l": "beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28064", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0004114", "l": "3',5'-cyclic-nucleotide phosphodiesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64126", "l": "hexadecanoate + L-phenylalanine => H2O + N-hexadecanoyl-L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050586", "l": "3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205649", "l": "p62 links damaged mitochondria to LC3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043250", "l": "sodium-dependent organic anion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62235", "l": "a thymidine(6-4)thymidine in DNA <=> a thymidine dimer in DNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62373", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA => (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23744", "l": "2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate"}, {"i": "EC:2.6.1.9", "l": "\"Histidinol-phosphate transaminase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010490", "l": "UDP-4-keto-rhamnose-4-keto-reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37418", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49849", "l": "(-)-dehydrodiconiferyl acid ketone + a quinone + H2O => (-)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854462", "l": "VLDLR binds VLDL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73718", "l": "UBF-1 Binds rDNA Promoter (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15602", "l": "(E)-cinnamoyl-CoA + (R)-3-phenyllactate => (E)-cinnamate + (R)-3-phenyllactoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38682", "l": "ATP + H2O + sphinganine(in) <=> ADP + H(+) + phosphate + sphinganine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52330", "l": "H(+) + H2O + N(omega)-hydroxy-L-arginine + oxidized [flavodoxin] => L-arginine + O2 + reduced [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5490269", "l": "AFXBO-C, AFNBO-C translocate from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672961", "l": "PP2A dephosphorylates inactive RAFs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.144", "l": "\"3-deoxyoctulosonase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879930", "l": "STAT5 is recruited by JAK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33851", "l": "GDP-alpha-D-mannose + N-tetracosanoylsphinganine-(1D-myo-inositol) = GDP + H(+) + mannosyl-alpha-1->6-inositol phospho-N-tetracosanoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14756", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] <=> acetate + androst-4-ene-3,17-dione + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43035", "l": "3-chloro-D-alanine <=> 2-aminoprop-2-enoate + chloride + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27318", "l": "uracil(in) = uracil(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41757", "l": "1-O-methyl-(9Z,12Z)-octadecadienoate + O2 => 1-O-methyl-(13S)-hydroperoxy-(9Z,11E)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951595", "l": "CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51741", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A => a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30705", "l": "CO2 + phenol => H(+) + salicylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374899", "l": "Release of noradrenaline  at the synapse (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33345", "l": "2-iminoacetate + H2O2 => glycine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030549", "l": "acetylcholine receptor activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173740", "l": "Factor B binds to C3(H2O) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029149", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55323", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> 2-heptanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl heptanoate + apo--[retinol-binding protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14968", "l": "an acyl phosphate + H2O <=> a carboxylate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56970", "l": "dCDP + H(+) + phosphoenolpyruvate => dCTP + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17918", "l": "[Glu(-Cys)](n)-Gly + glutathione + H(+) => [Glu(-Cys)](n+1)-Gly + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-877281", "l": "PIAS1 binds p-STAT1 dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018757", "l": "deisopropylhydroxyatrazine aminohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9029690", "l": "Caspase-6 translocates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111966", "l": "GRK2 binds CALM1:4Ca2+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25244", "l": "(S)-2-ureidoglycine + H2O <=> (S)-ureidoglycolate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41998", "l": "globoside GalGb4Cer (d18:1(4E)) + H(+) + UDP => globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66307", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-mannosylinositol-1-phosphoceramide <=> a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-alpha-mannosylinositol-1-phosphoceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130151", "l": "Dimerization of DAP12 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682388", "l": "Autophagosome maturation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28333", "l": "H2O + ITP <=> H(+) + IDP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213241", "l": "Formation of nonameric complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62960", "l": "cholesta-5,7-dien-3beta-ol(in) = cholesta-5,7-dien-3beta-ol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417927", "l": "P2Y2 receptor binds ATP and UTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700656", "l": "alectinib resistant ALK mutants don't bind alectinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52762", "l": "(Z)-1-(glycyl-L-cystein-S-yl)-2-phenylacetohydroximate + L-glutamate => (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395320", "l": "Latent TGF-beta-1 binds integrins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47698", "l": "(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + phosphate => (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247839", "l": "Retromer associates with WLS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688884", "l": "Defective CSF2RB does not bind SFTPs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33897", "l": "H(+) + NADH + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose => NAD(+) + trans,octa-cis-decaprenylphospho-beta-D-arabinofuranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9007926", "l": "ATRX binds DAXX (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16432", "l": "ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25036", "l": "all-trans-retinol + NADP(+) <=> all-trans-retinal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35846", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1-acyl-sn-glycero-3-phosphoethanolamine + a cardiolipin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61521", "l": "AH2 + dopamine => 3-tyramine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59713", "l": "D-maltotetraono-1,5-lactone + H2O => D-maltotetraonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102481", "l": "3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37821", "l": "1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848110", "l": "SOCS3 binds activated PTK6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12332", "l": "ATP + Fe(3+)(out) + H2O = ADP + Fe(3+)(in) + H(+) + phosphate"}, {"i": "EC:7.2.2.7", "l": "\"ABC-type Fe(3+) transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46706", "l": "2-hydroxybenzoyl-5'-AMP + diphosphate => ATP + H(+) + salicylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13008", "l": "(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine <=> H(+) + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56172", "l": "FMN + O2 = 8-demethyl-8-formylriboflavin 5'-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013009", "l": "RHOA binds effectors at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052912", "l": "23S rRNA (guanine(748)-N(1))-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14997", "l": "deoxylimonoate + H2O = deoxylimononate D-ring-lactone + H(+)"}, {"i": "EC:3.1.1.46", "l": "\"Deoxylimonate A-ring-lactonase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23174", "l": "ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] => ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37743", "l": "dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2"}, {"i": "EC:2.5.1.129", "l": "\"Flavin prenyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22826", "l": "2-deoxy-alpha-D-ribose 1-phosphate + uracil => 2'-deoxyuridine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5632677", "l": "PTCH is internalized (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621571", "l": "CD209 binds ICAM2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.369", "l": "\"Enterobactin C-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433808", "l": "viral dsRNA: TLR3: TICAM1 recruits TRAF6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83788", "l": "Binding of TFIIIC to Type 2 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418662", "l": "Src activation following P2Y purinoceptor activation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.93"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005524", "l": "ATP binding"}, {"i": "REACT:R-HSA-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112510", "l": "IL6ST is tyrosine phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177934", "l": "EGFR autophosphorylation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52160", "l": "(E)-phenylacetaldehyde oxime = (Z)-phenylacetaldehyde oxime"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54598", "l": "2-hydroxyhexadecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + hexadecanoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035956", "l": "Defective CYP17A1 does not cleave 17aHPROG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33668", "l": "H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine + NADPH + O2 => H2O + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46672", "l": "aldosterone + H(+) + NADPH = 5beta-dihydroaldosterone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102218", "l": "starch, H2O dikinase activity"}, {"i": "MetaCyc:RXN-12203"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28998", "l": "H(+)(out) + L-threonine(in) <=> H(+)(in) + L-threonine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39638", "l": "3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39105", "l": "(24R)-ethylcholest-5-en-3beta-ol(out) + ADP + H(+) + phosphate => (24R)-ethylcholest-5-en-3beta-ol(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16334", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP] => diphosphate + holo-[citrate lyase ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247844", "l": "WNT ligands traffic to the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59912", "l": "(E)-4-hydroxynon-2-enal + H2O + NADP(+) = (E)-4-hydroxynon-2-enoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673322", "l": "p-T,Y-MAPK8 translocates from the cytosol to the nucleoplasm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45106", "l": "mitomycin A + S-adenosyl-L-homocysteine => 6-demethylmitomycin A + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60409", "l": "Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O => Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine] + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2002440", "l": "Removal of fibrillar collagen C-propeptides (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28569", "l": "3 2,3-dihydroxybenzoyl-5'-AMP + 3 L-seryl-5'-AMP <=> 6 AMP + enterobactin + 7 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159761", "l": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204392", "l": "Basigin binds MCT1, MCT3 and MCT4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604360", "l": "Initial activation of proMMP2 by MMP14 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29126", "l": "nitrate(out) + ubiquinol-8(in) <=> H2O(out) + nitrite(out) + ubiquinone-8(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55493", "l": "ent-cassa-12,15-dien-2-one + O2 + reduced [NADPH--hemoprotein reductase] => ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.25", "l": "\"Mitogen-activated protein kinase kinase kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28879", "l": "H(+)(in) + L-tryptophan(in) = H(+)(out) + L-tryptophan(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070412", "l": "R-SMAD binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247847", "l": "WLS is endocytosed to the early endosome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018807", "l": "6-hydroxycyclohex-1-ene-1-carboxyl-CoA hydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39187", "l": "(3R)-hydroxydocosanoyl-CoA = (2E)-docosenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-844438", "l": "NLRP1 oligomerizes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211164", "l": "AKT phosphorylates FOXO1A (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707516", "l": "FeHM dissociates from MetHb (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700149", "l": "Active ALK binds PLCG1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694462", "l": "ABHD6,12 hydrolyse 3AG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64683", "l": "benzoyl-CoA + ethanol <=> CoA + ethyl benzoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035446", "l": "cysteine-glucosaminylinositol ligase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004983", "l": "neuropeptide Y receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-421835", "l": "trans-Golgi Network Vesicle Scission (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43352", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol(in) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13750", "l": "a ribonucleoside 5'-triphosphate + AMP => a ribonucleoside 5'-diphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114256", "l": "CYCS:APAF1 binds procaspase-9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15105", "l": "kaempferol + S-adenosyl-L-methionine = H(+) + kaempferide + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.155", "l": "\"Kaempferol 4'-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21696", "l": "N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11647", "l": "a (2R,3R)-flavan-3-ol + 2 NADP(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54865", "l": "H(+) + NADPH + O2 + sulcatone => 4-methylpent-3-en-1-yl acetate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003858", "l": "3-hydroxybutyrate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809309", "l": "MTMR6 binds MTMR9 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38251", "l": "hexadecan-1-ol + octadecanoyl-CoA = CoA + hexadecanyl octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.17"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17506", "l": "H2O + N-(long-chain fatty acyl)ethanolamine => a long-chain fatty acid + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31940", "l": "2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + O2 + reduced [NADPH--hemoprotein reductase] => DIBOA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627350", "l": "SMAC (DIABLO) binds XIAP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.5"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070191", "l": "methionine-R-sulfoxide reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56100", "l": "[small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+) = [small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate"}, {"i": "EC:2.7.7.100", "l": "\"SAMP-activating enzyme\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64411", "l": "H(+)(out) + N-acetylmuramyl-L-alanyl-D-isoglutamine(out) <=> H(+)(in) + N-acetylmuramyl-L-alanyl-D-isoglutamine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51849", "l": "8-methylmenaquinone-6 + succinate => 8-methylmenaquinol-6 + fumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3221982", "l": "BANP binds TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2201341", "l": "Endocytosis of TRAM (TICAM2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23322", "l": "CoA + H(+) + N(2)-malonyl-D-tryptophan => D-tryptophan + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047510", "l": "(S)-2-methylmalate dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65051", "l": "4-acetoxybenzyl alcohol + NAD(+) <=> 4-acetoxybenzaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668714", "l": "RAC1:GTP binds NOX1 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21750", "l": "H(+) + methylglyoxal + NADPH => (S)-lactaldehyde + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14769", "l": "(S)-nicotine + A + H2O = (S)-6-hydroxynicotine + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26278", "l": "Co-precorrin-4 + S-adenosyl-L-methionine => Co-precorrin-5A + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730882", "l": "Phosphorylation of PKC-theta (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65907", "l": "3-hydroxy-L-kynurenine + glyoxylate <=> 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5631941", "l": "SESN1,2,3 bind AMPK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21480", "l": "2-furoyl-CoA + A + H2O = 5-hydroxy-2-furoyl-CoA + AH2 + H(+)"}, {"i": "EC:1.3.99.8", "l": "\"2-furoyl-CoA dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22637", "l": "dCTP + H2O => dCMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380574", "l": "Dopamine synaptic vesicle docking and priming (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60475", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) + 5-formyltetrahydrofolate(out) <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) + 5-formyltetrahydrofolate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57086", "l": "a fatty acid + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40776", "l": "2-amino-2-phenylacetonitrile + H(+) + 2 H2O => D-alpha-phenylglycine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017083", "l": "4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity"}, {"i": "RHEA:14257", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)"}, {"i": "EC:2.4.1.152", "l": "\"4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30387", "l": "GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP + H(+)"}, {"i": "EC:2.7.7.78", "l": "\"GDP-D-glucose phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1671687", "l": "PRLR activation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199576", "l": "KIR3DL2 interacting with HLA-A3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4518585", "l": "NLK mRNA translation controlled by miR-92b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113442", "l": "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097645", "l": "amylin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18260", "l": "coproporphyrinogen III + 2 H(+) + O2 <=> 2 CO2 + 2 H2O + protoporphyrinogen IX"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047135", "l": "bis-gamma-glutamylcystine reductase activity"}, {"i": "MetaCyc:1.6.4.9-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879942", "l": "The receptor is activated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381087", "l": "Dimerization of PERK (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16255", "l": "H(+) + NADH + phenanthrene-3,4-diol => (3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199456", "l": "PTEN dephosphorylates PIP3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6805981", "l": "HMGB1 release from cells (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44415", "l": "3-demethylubiquinol-10 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44038", "l": "12,13-dihydroxy-(9Z)-octadecenoate => 12,13-epoxy-(9Z)-octadecenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13300", "l": "3 H(+) + malonyl-CoA + 2 NADH + octadecanoyl-CoA <=> CO2 + CoA + eicosanoyl-CoA + H2O + 2 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433501", "l": "Interaction of other adapter proteins with p-KIT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61082", "l": "(+)-echitovenine + CoA => (+)-minovincinine + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424485", "l": "Release of p-PLCG1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45858", "l": "4-hydroxy-6-(2-hydroxytridecyl)-pyran-2-one + 2 CO2 + 3 CoA => 3-hydroxytetradecanoyl-CoA + 2 H(+) + 2 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177942", "l": "EGFR binds EGF ligand (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66606", "l": "a 2'-deoxyuridine in double-stranded DNA + NH4(+) => a 2'-deoxycytidine in double-stranded DNA + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004549", "l": "tRNA-specific ribonuclease activity"}, {"i": "REACT:R-HSA-5696813", "l": "TSEN complex cleaves the intron from pre-tRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4411373", "l": "NLK translocates to nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170149", "l": "Translocation of active Cdc25C to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19236", "l": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] <=> H(+) + hexadecanoate + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48525", "l": "ganglioside GP1c + H2O => ganglioside GQ1c + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13294", "l": "3 H(+) + malonyl-CoA + 2 NADPH + octadecanoyl-CoA => CO2 + CoA + eicosanoyl-CoA + H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29253", "l": "2 H(+)(in) + Na(+)(out) => 2 H(+)(out) + Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42581", "l": "ATP + L-serine + tRNA(Sec) => AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0030695", "l": "GTPase regulator activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018817", "l": "2-oxo-hept-3-ene-1,7-dioate hydratase activity"}, {"i": "RHEA:42072", "l": "(4Z)-2-oxohept-4-enedioate + H2O = (4S)-4-hydroxy-2-oxoheptanedioate"}, {"i": "EC:4.2.1.163", "l": "\"2-oxo-hept-4-ene-1,7-dioate hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14996", "l": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH <=> a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24546", "l": "(S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+) => H2O + L-lysyl-[protein] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58060", "l": "2-sulfinoacetaldehyde + H2O = acetaldehyde + H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30917", "l": "a fatty acid + beta-D-glucosyl-(1<->1)-sphing-4-enine => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44933", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322431", "l": "XIAP binds TLE (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870466", "l": "RGGT:CHM binds RABs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.7.2", "l": "\"7-hydroxymethyl chlorophyll a reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56807", "l": "2 cob(II)yrinate a,c diamide--[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] <=> 2 cob(I)yrinate a,c diamide--[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47752", "l": "5-hydroxy-3-methyl-L-tyrosine + S-adenosyl-L-methionine = 5-hydroxy-3-methyl-O-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190258", "l": "FGFR2c binds to FGF (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70482", "l": "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602901", "l": "Defective GSS does not synthesize GSH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177934", "l": "EGFR autophosphorylation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003860", "l": "3-hydroxyisobutyryl-CoA hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211948", "l": "CYP3A4 can N-demethylate loperamide (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14511", "l": "3-epihydroxymugineate + CO2 + H(+) + succinate => 2-oxoglutarate + mugineate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802922", "l": "Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19090", "l": "S-adenosyl-L-methionine + uroporphyrinogen III => H(+) + precorrin-1 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-913675", "l": "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33923", "l": "(1R,4R)-5-oxo-1,2-campholide = [(1R)-2,2,3-trimethyl-2-oxocyclopent-3-en-1-yl]acetate + H(+)"}, {"i": "RHEA:34415", "l": "(1R,4R)-bornane-2,5-dione + FMNH2 + O2 = (1R,4R)-5-oxo-1,2-campholide + FMN + H(+) + H2O"}, {"i": "EC:1.14.14.108", "l": "\"2,5-diketocamphane 1,2-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53978", "l": "(14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202394", "l": "Translocation of CARMA1 to Plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39611", "l": "3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38792", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.41"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18401", "l": "(E)-4-hydroxyphenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] = (S)-4-hydroxymandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.37", "l": "\"4-hydroxyphenylacetaldehyde oxime monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799097", "l": "ATM phosphorylates ZNF420 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614369", "l": "Transport of HCMV DNA Into the Nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018482", "l": "4-formylbenzenesulfonate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2731141", "l": "Syndecan-1 binds fibronectin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54217", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 => 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43571", "l": "3,6-anhydro-alpha-L-galactopyranose + H2O + NAD(+) <=> 3,6-anhydro-L-galactonate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35344", "l": "3-hydroxydocosanoyl-CoA + NADP(+) => 3-oxodocosanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53853", "l": "glycocholate + NAD(+) => 7-oxo-glycodeoxycholate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168882", "l": "Association of NP into rafts (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63362", "l": "(S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-oxazole-[protein] + H2O2 => (S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873917", "l": "Translocation of STAT1 dimer to nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44086", "l": "AMP + diphosphate + heptadecanoyl-CoA => ATP + CoA + heptadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45899", "l": "an N-acyl-sphingoid base + CDP-ethanolamine <=> an N-acyl-sphingoid 1-phosphoethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003848", "l": "2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40882", "l": "2 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49221", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + CTP => CMP-beta-3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983298", "l": "IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14106", "l": "L-proline + NAD(+) => 1-pyrroline-5-carboxylate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32857", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11637", "l": "NADP(+) + prostaglandin E1 => 15-oxoprostaglandin E1 + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37504", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27424", "l": "(2E,6E)-farnesyl diphosphate <=> (3E,6E)-alpha-farnesene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159773", "l": "Furin cleaves pro-protein S to protein S (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623281", "l": "FOXO1:PPARGC1A,FOXO4 binds PCK1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10808", "l": "(S)-2-hydroxypropylphosphonate + H2O2 = (1R,2S)-epoxypropylphosphonate + 2 H2O"}, {"i": "EC:1.11.1.23", "l": "\"(S)-2-hydroxypropylphosphonic acid epoxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6791016", "l": "SFTPB binds itself (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814153", "l": "ADO oxidises 2AET to HTAU (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.86", "l": "\"ADAM 17 endopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514823", "l": "Fibrillin-1 degradation by ELANE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693250", "l": "RHOD binds effectors at the Golgi membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33839", "l": "(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin + H(+) = 7-O-geranyl-2-O,3-dimethylflaviolin + diphosphate"}, {"i": "EC:2.5.1.125", "l": "\"7-geranyloxy-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41850", "l": "NADP(+) + octanoyl-[ACP] => (2E)-octenoyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033788", "l": "leucoanthocyanidin reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51373", "l": "(9Z)-hexadecenoyl-CoA + glycine => CoA + H(+) + N-(9Z-hexadecenoyl)-glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31181", "l": "3-oxododecanoyl-CoA + H(+) + NADH => (3S)-3-hydroxydodecanoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0003713", "l": "transcription coactivator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5603467", "l": "Activated protein C is released from PROCR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58957", "l": "a ribonucleotide in RNA + S-adenosyl-L-methionine => a 2'-O-methylribonucleotide in RNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65676", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontadienoyl)-sphing-4-enine = a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontadienoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62754", "l": "(S)-2-methylbutanoate + H(+) + pravastatin diol lactone => H2O + pravastatin lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31256", "l": "(2S)-2-acetolactate => 3-hydroxy-3-methyl-2-oxobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727819", "l": "TAK1 phosphorylates MKK6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38363", "l": "1-octadecanoylglycerol + H2O = glycerol + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2186771", "l": "RNF111 binds SMAD7 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50667", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112037", "l": "Inactivation of PLC beta (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106235", "l": "ceramide-1-phosphate phosphatase activity"}, {"i": "RHEA:50888", "l": "an N-acylsphingoid base 1-phosphate + H2O = an N-acyl-sphingoid base + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32722", "l": "L-dihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-5-(methylsulfanyl)pentanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684801", "l": "p-Y7-CLEC1B dimer:PDPN binds SYK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372852", "l": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5679239", "l": "ULK complex translocates to the ER (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800250", "l": "TP53 stimulates BCL6 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928614", "l": "EFNB:GRB4 binds GIT1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9017491", "l": "RHOJ GEFs activate RHOJ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2562541", "l": "TLR4-induced ripoptosome assembly (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53240", "l": "cholesta-5,7-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220985", "l": "NOTCH1 PEST domain mutants stimulate MYC transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16779", "l": "ADP + H(+) + K(+)(in) + phosphate => ATP + H2O + K(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400496", "l": "Signal peptidase hydrolyzes preproGIP to proGIP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13739", "l": "an alk-2-enal + H(+) + NADPH => an n-alkanal + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508513", "l": "PTK2B binds JAK3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.19"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22120", "l": "CoA + GTP + succinate = GDP + phosphate + succinyl-CoA"}, {"i": "EC:6.2.1.4", "l": "\"Succinate--CoA ligase (GDP-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58231", "l": "L-asparaginyl-[protein] + NAD(+) <=> H(+) + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008984", "l": "protein-glutamate methylesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32119", "l": "GDP-valienol + validamine 7-phosphate = GDP + H(+) + validoxylamine A 7'-phosphate"}, {"i": "EC:2.5.1.135", "l": "\"Validamine 7-phosphate valienyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50073", "l": "ATP + H2O + tauroursodeoxycholate(in) => ADP + H(+) + phosphate + tauroursodeoxycholate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62289", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate => (S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11313", "l": "atrazine + H2O => chloride + H(+) + hydroxyatrazine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730884", "l": "Phosphorylation of NTAL by p-SYK/Lyn (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30881", "l": "2 H(+) + NADH + propynoate => H2O + NAD(+) + prop-2-ynal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57504", "l": "3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16630", "l": "(S)-malyl-CoA => acetyl-CoA + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211962", "l": "CYP4F11 16-hydroxylates 3OH-PALM (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602484", "l": "Activation of proMMP11 by FURIN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983519", "l": "IL35 binds IL12RB2:IL12RB2 receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53666", "l": "H(+) + 2 H2O + pyridinestrone carboxylate => (2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28583", "l": "ATP + dUDP => ADP + dUTP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050251", "l": "retinol isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24574", "l": "[(1->4)-alpha-D-glucosyl](n+1) + D-fructose => [(1->4)-alpha-D-glucosyl](n) + sucrose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39290", "l": "[Co(I) trimethylamine-specific corrinoid protein] + H(+) + trimethylamine <=> [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0009674", "l": "potassium:sodium symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35260", "l": "7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O => 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15881", "l": "ATP + L-seryl-[Fas-activated protein] = ADP + H(+) + O-phospho-L-seryl-[Fas-activated protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51052", "l": "5alpha-androstan-3,17-dione + A = 5alpha-androst-1-ene-3,17-dione + AH2"}, {"i": "EC:1.3.99.4", "l": "\"3-oxosteroid 1-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55596", "l": "globoside NOR1 + UDP-N-acetyl-alpha-D-galactosamine = globoside NORint + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26007", "l": "di-trans,nona-cis-dodecaprenyl phosphate + UDP-alpha-D-galacturonate => beta-D-galacturonosyl di-trans,nona-cis-dodecaprenyl phosphate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389862", "l": "Conversion of glyoxylate to oxalate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38867", "l": "uridine(516) in 16S rRNA = pseudouridine(516) in 16S rRNA"}, {"i": "EC:5.4.99.19", "l": "\"16S rRNA pseudouridine(516) synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0048031", "l": "trisaccharide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684096", "l": "CDK2 phosphorylates RBBP8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216048", "l": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014296", "l": "RAC2 GEFs activate RAC2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53057", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine => H(+) + isowyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5220952", "l": "TET1,2,3 oxidizes 5-formylcytosine to 5-carboxylcytosine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36557", "l": "CoA + H(+) + N-eicosanoylsphinganine => eicosanoyl-CoA + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66409", "l": "ATP + glutathione(in) + glycochenodeoxycholate(in) + H2O => ADP + glutathione(out) + glycochenodeoxycholate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35951", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate = diphosphate + N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate"}, {"i": "EC:2.5.1.105", "l": "\"7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3791155", "l": "Laminin-322 degradation by MMP14 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418456", "l": "cGMP is degraded by PDEs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25429", "l": "ATP + N-acetyl-D-hexosamine => ADP + H(+) + N-acetyl-alpha-D-hexosamine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2328037", "l": "Fibrillin-1 binds integrins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63941", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + N-(hexanoyl)sphing-4-enine + O2 => 2 [Fe(III)-cytochrome b5] + 2 H2O + N-hexanoyl-sphinga-4E,14Z-dienine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22452", "l": "[phosphate](n+1) + n H2O = n H(+) + (n+1) phosphate"}, {"i": "EC:3.6.1.10", "l": "\"Endopolyphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55431", "l": "ferruginol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-hydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15720", "l": "daunorubicin + H(+) + NADPH + O2 <=> doxorubicin + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913446", "l": "Interleukin-5 is a homodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13026", "l": "3-methyl-(2E)-butenoyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] => N(6)-biotinyl-L-lysyl-[protein] + trans-3-methylglutaconyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64306", "l": "1-phenylpropan-1-one + L-alanine => 1-phenylpropylamine + pyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009978", "l": "allene oxide synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66566", "l": "5-histaminyl-L-glutamyl-[protein] + NH4(+) => histamine + L-glutaminyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1470009", "l": "Phosphorylation of STATs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21766", "l": "biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase] => heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29106", "l": "5 H(+)(in) + menaquinone-8 + NADH <=> 4 H(+)(out) + menaquinol-8 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015019", "l": "heparan-alpha-glucosaminide N-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700168", "l": "Active ALK phosphorylates IRS1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956639", "l": "RUNX1 binds YAP1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18452", "l": "A + arsenite + H2O <=> AH2 + arsenate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42944", "l": "cytidine(40) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(40) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36565", "l": "GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADPH => GDP-beta-L-colitose + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102899", "l": "dehydroabietadienol hydroxylase activity"}, {"i": "MetaCyc:RXN-8532"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60817", "l": "2-oxoglutarate + gibberellin A14 aldehyde + O2 => CO2 + gibberellin A14 + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40842", "l": "FAD + H(+) + nonanoyl-CoA <=> (2E)-nonenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928624", "l": "EPHBs bind EFNBs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72722", "l": "eIF2 activation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61779", "l": "rebaudioside D + UDP-alpha-D-glucose <=> H(+) + rebaudioside M + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63099", "l": "ilicicolin A epoxide <=> ilicicolin C"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0016434", "l": "rRNA (cytosine) methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296043", "l": "Activation of HCN channels (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647977", "l": "ICMT methylates S-Farn RAS proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57662", "l": "(+)-nootkatone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (+)-valencene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41777", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)/18:0) => CMP + ganglioside GM2 (d18:1(4E)/18:0) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168897", "l": "LRP1 (CD91) binds Hemopexin:heme (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50284", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30244", "l": "4 L-ascorbate + O2 => 2 H2O + 4 monodehydro-L-ascorbate radical"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.96", "l": "\"Lactocepin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381608", "l": "cAMP activates EPAC2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36702", "l": "3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP <=> 8-desmethylnovobiocic acid + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42853", "l": "3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine => (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22278", "l": "a 2-oxocarboxylate + 2 H(+) + NADH => 2-oxoaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382055", "l": "Grb7 binds to the active PDGF receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29574", "l": "H(+)(in) + L-idonate(in) <=> H(+)(out) + L-idonate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17999", "l": "Co-precorrin-3 + H(+) + S-adenosyl-L-homocysteine => Co-precorrin-2 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33948", "l": "2-deoxystreptamine + UDP-N-acetyl-alpha-D-glucosamine => 2'-N-acetylparomamine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35941", "l": "diphosphate + tryprostatin B => brevianamide F + dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357845", "l": "RIPK1 is deubiquitinated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25256", "l": "ATP + N-acetyl-D-mannosamine <=> ADP + H(+) + N-acetyl-D-mannosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22748", "l": "4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59281", "l": "L-asparagine => D-asparagine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23117", "l": "4-hydroxybenzoate + ATP + CoA => 4-hydroxybenzoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53122", "l": "5alpha-dihydrotestosterone sulfate + H(+) + NADPH => (3beta,5alpha,17beta)-3-hydroxyandrostan-17-yl sulfate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203070", "l": "Association of profilin with monomeric actin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15189", "l": "2 [Fe(III)cytochrome c553] + formate = 2 [Fe(II)cytochrome c553] + CO2 + H(+)"}, {"i": "EC:1.17.2.3", "l": "\"Formate dehydrogenase (cytochrome c-553)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2169046", "l": "Degradation of TGF-beta receptor complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22239", "l": "2-deoxy-D-glucose 6-phosphate + H2O <=> 2-deoxy-D-glucose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2219524", "l": "PDPK1 binds PIP2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55097", "l": "(3S)-3-hydroxypentanoyl-CoA + H2O => (3S)-3-hydroxypentanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64544", "l": "acetyl-CoA + 8 AH2 + ATP + 4 H(+) + holo-[ACP] + L-tyrosine + 7 malonyl-CoA + 2 S-adenosyl-L-methionine = 8 A + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212222", "l": "PRC2 recruits DNA methyltransferases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42955", "l": "cytidine(49) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(49) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22061", "l": "(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54192", "l": "L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102346", "l": "3-hydroxy-cerotoyl-CoA dehydratase activity"}, {"i": "MetaCyc:RXN-13305"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632412", "l": "PTK2 is recruited to methylated ESR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420233", "l": "VIP receptors bind VIP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15664", "l": "(E)-4-coumaroyl-CoA + an anthocyanidin 3,5-di-O-beta-D-glucoside <=> an anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16326", "l": "1-phospho-alpha-D-glucuronate + H(+) + UTP => diphosphate + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29830", "l": "Mg(2+)(in) <=> Mg(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47411", "l": "(24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O <=> (24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14582", "l": "H(+) + 2 monodehydro-L-ascorbate radical + NADH => 2 L-ascorbate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62339", "l": "AMP + ATP <=> adenosine 3'-diphosphate,5'-phosphate + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1364044", "l": "PRLR:JAK2 dimerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58611", "l": "2 L-ascorbate + N-decanoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-decanoyl-(2S)-hydroxyglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63125", "l": "H2O + N-octadecanoyl ethanolamine => ethanolamine + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48353", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31201", "l": "(2E)-octenoyl-CoA + H2O => (3S)-hydroxyoctanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64956", "l": "dTTP + 2 H2O = dTMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709547", "l": "ESTG binds ESR2:chaperone complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56654", "l": "12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705458", "l": "p-Y-STAT1,3,5 dimer enhances expression of SOCS3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686578", "l": "Activated ATM phosphorylates ABL1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964939", "l": "Phosphorylation of shikimate (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43206", "l": "2'-O-methylcytidine(1409) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1409) in 16S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14432", "l": "a [oligopeptide](in) + ATP + H2O <=> a [oligopeptide](out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28845", "l": "choline(out) + H(+)(out) => choline(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20784", "l": "H2O + N(omega)-(ADP-D-ribosyl)-L-arginine = ADP-D-ribose + L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35962", "l": "H(+) + NADPH + O2 + tryprostatin B <=> demethoxyfumitremorgin C + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033454", "l": "GCC codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675206", "l": "PEA15 binds MAPK monomers and dimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917696", "l": "Cargo Sequestration (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37562", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52809", "l": "adenosine in U6 snRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33470", "l": "ergosta-5,7,24(28)-trien-3beta-ol + H(+) + NADPH + O2 <=> ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33692", "l": "2-(1-hydroxyethyl)thiamine diphosphate + 2-oxobutanoate => (S)-2-ethyl-2-hydroxy-3-oxobutanoate + thiamine diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46952", "l": "2 formate + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] = 2 CO2 + H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.17.1.11", "l": "\"Formate dehydrogenase (NAD(+), ferredoxin)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44622", "l": "a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46015", "l": "(S)-malate + a quinone <=> a quinol + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612672", "l": "ERBB4s80:ESR1 binds ERBB4 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62899", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc + GDP-beta-L-fucose <=> alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102690", "l": "isopentenyladenine UDP glycosyltransferase activity"}, {"i": "MetaCyc:RXN-4728"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981497", "l": "ST3GAL1-4 can add a sialic acid to the T antigen at the alpha 3 position (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38820", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9649108", "l": "HTR3A pentamer binds 5HT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647994", "l": "RAS proteins are depalmitoylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57482", "l": "2,3-dihydroxydodecanoate + H2O => 2-hydroxydodecanoate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58885", "l": "AH2 + alpha-N-dichloroacetyl-p-aminophenylserinol + 2 O2 => A + chloramphenicol + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63503", "l": "H(+) + NADPH + S-nitrosoglutathione <=> NADP(+) + sulfinamide glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9659820", "l": "RB1 translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158300", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30195", "l": "15,9'-di-cis-phytofluene + plastoquinone-9 = 9,9',15-tri-cis-zeta-carotene + plastoquinol-9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14085", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA = 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0010297", "l": "heteropolysaccharide binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004499", "l": "N,N-dimethylaniline monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28446", "l": "1-deoxy-D-xylulose(in) = 1-deoxy-D-xylulose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62364", "l": "FMNH2 + O2 + thymine = (Z)-2-methylureidoacrylate + FMN-N(5)-oxide + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58222", "l": "H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide => L-lysyl-[protein] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5681987", "l": "LC3 is cleaved by ATG4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62849", "l": "GDP-beta-L-fucose + methyl 8-{[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13832", "l": "GDP-alpha-D-rhamnose + NADP(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26431", "l": "(+)-copalyl diphosphate + H2O => diphosphate + phyllocladan-16alpha-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10164", "l": "(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate"}, {"i": "EC:4.2.1.11", "l": "\"Phosphopyruvate hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418866", "l": "PITPalpha binds DCC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.1", "l": "\"Alkaline phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28030", "l": "[thioredoxin]-disulfide + dGDP + H2O = [thioredoxin]-dithiol + GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61586", "l": "5-methylcytidine(72) in tRNA(Cys) + H(+) + S-adenosyl-L-homocysteine => cytidine(72) in tRNA(Cys) + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354060", "l": "Translocation of RIAM to plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15712", "l": "kaempferol + UDP-alpha-D-galactose <=> H(+) + kaempferol 3-O-beta-D-galactoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59735", "l": "biotinyl-5'-AMP + L-lysyl-[protein] <=> AMP + 2 H(+) + N(6)-biotinyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2470483", "l": "Activin AB,B binds Activin Receptor ACVR2A,B:ACVR1C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5662608", "l": "MT2A binds cadmium (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48073", "l": "ganglioside GM1 (d18:1(4E)) + H2O => ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5221014", "l": "TET1,2,3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53551", "l": "prostaglandin J2 <=> Delta(12)-prostaglandin J2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392530", "l": "p-S400-Cot phosphorylates NIK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65275", "l": "chrodrimanin C + H(+) + NADPH + O2 <=> chrodrimanin H + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.3.-", "l": "\"Phosphotransferases with a nitrogenous group as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201443", "l": "Type II receptor phosphorylates type I receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654511", "l": "FGFRL1 dimer binds FGFs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33704", "l": "(4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA => CoA + H(+) + N-hexacosanoyl-eicosan-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16312", "l": "H2O + taurochenodeoxycholate <=> chenodeoxycholate + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12823", "l": "acetaldehyde + D-glyceraldehyde 3-phosphate => 2-deoxy-D-ribose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2168888", "l": "Alpha1-Microglobulin binds heme (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.47"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222384", "l": "Glutathione scavenges nitrosyl (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140840", "l": "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37930", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate <=> 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25953", "l": "1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde => 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030248", "l": "cellulose binding"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0019777", "l": "Atg12 transferase activity"}, {"i": "REACT:R-HSA-5681999", "l": "ATG10 transfers ATG12 from ATG7 to ATG10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940100", "l": "CDK1 phosphorylates VCPIP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34746", "l": "15-methylhexadecasphinganine 1-phosphate <=> 13-methyltetradecanal + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62418", "l": "4-hydroxybenzaldehyde + acetyl-CoA => (E)-4-coumaroyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432067", "l": "Aquaporin-4 passively transports water out of cell (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655832", "l": "Expression of Geranylgeranyl Pyrophosphate Synthase (GGPS1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52765", "l": "(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O => (E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73596", "l": "dCMP + H2O => dUMP + NH4+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23525", "l": "1-O-(trans-cinnamoyl)-beta-D-glucose + an alcohol => an alkyl cinnamate + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682010", "l": "ATG10:ATG12 binds ATG5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5444511", "l": "Formation of MSH2:MSH3 Complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909718", "l": "Formation of p-STAT1 homodimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:1990042", "l": "glycerol dehydrogenase [NAD(P)+] activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16102", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate => n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850818", "l": "SPINK9 binds KLK5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9690493", "l": "RHOB binds effectors on endosomes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36850", "l": "FAD + L-threonyl-[protein] <=> AMP + FMN-L-threonyl-[protein] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16464", "l": "ATP + H2O + urate(in) <=> ADP + H(+) + phosphate + urate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1483087", "l": "PI is exchanged with PC by PITPNB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0045183", "l": "translation factor activity, non-nucleic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59743", "l": "L-cysteinyl-[protein] + octadecanoyl-CoA <=> CoA + S-octadecanoyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21490", "l": "beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalnigrein + H(+) => dalnigrein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193641", "l": "IKK-beta is recruited (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654603", "l": "Activated FGFR2 binds FRS3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39367", "l": "(2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H(+) + NADPH = (13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805981", "l": "HMGB1 release from cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183072", "l": "EGFR non-clathrin mediated endocytosis (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605595", "l": "Hexosaminidase A cleaves GalNAc from GM2 to form GM3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1973968", "l": "Beta-defensins 4A and 103 bind CCR2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46845", "l": "4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 => 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53958", "l": "4-aminobutanoyl-[BtrI ACP] + CO2 => gamma-L-glutamyl-[BtrI ACP] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19732", "l": "acetoacetate + H(+) <=> acetone + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21937", "l": "carbamoyl phosphate + putrescine => H(+) + N-carbamoylputrescine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54449", "l": "H2O + N-acyl-L-alpha-aminoacyl-tRNA => an N-acyl-L-amino acid + H(+) + tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44335", "l": "ATP + L-alanine + L-anticapsin <=> ADP + bacilysin + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228406", "l": "tetX HC transports tetX LC from target cell endosome membrane into cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15655", "l": "ADP + beta-D-fructose 2,6-bisphosphate + H(+) => ATP + beta-D-fructose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158860", "l": "SULT1A1 dimer sulfonates NHABP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450550", "l": "PKCalpha phosphorylates HuR (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950731", "l": "CRLF1:IL27 translocates to the extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052927", "l": "CTP:tRNA cytidylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937177", "l": "AHR:TCDD binds ARNT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56693", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 => 4-[(E)-2-isocyanoethenyl]phenol + 2 CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53101", "l": "2-hydroxyestrone + S-adenosyl-L-methionine => 2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005109", "l": "frizzled binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102109", "l": "tricaffeoyl spermidine O-methyltransferase activity"}, {"i": "MetaCyc:RXN-11261"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009028", "l": "tartronate-semialdehyde synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649856", "l": "Oxidative damage to the AP site (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952807", "l": "p-Y693-STAT4 dissociates after IL12:IL12R interaction (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13901", "l": "H2O + N-(aminomethyl)urea = N-(hydroxymethyl)urea + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212380", "l": "Formation of TRAP coactivator complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627078", "l": "XIAP binds CASP9 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362386", "l": "Glycosylation of Hh (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14544", "l": "choloyl-CoA + H2O <=> cholate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46118", "l": "D-glyceraldehyde + pyruvate => 2-dehydro-3-deoxy-D-galactonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61372", "l": "4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O = 4-methylumbelliferone beta-D-glucuronate(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53996", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451310", "l": "Activation of Edited Kainate receptors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56529", "l": "chloride + D-tryptophan + FADH2 + O2 => 6-chloro-D-tryptophan + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029270", "l": "Recruitment of PLCgamma to membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40440", "l": "6-sulfo-D-quinovose => 6-deoxy-6-sulfo-D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52625", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-glutamate => [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66275", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1564112", "l": "Collagen type VI degradation by MMP2,9,11 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981657", "l": "IL34 dimer binds PTPRZ1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25323", "l": "H(+) + N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine => N-methylethanolamine phosphate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018675", "l": "(S)-limonene 6-monooxygenase activity"}, {"i": "MetaCyc:--LIMONENE-6-MONOOXYGENASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56541", "l": "(9Z)-octadecenoyl-CoA + 1,2-dihexanoyl-sn-glycerol => 1,2-dihexanoyl-3-(9Z-octadecenoyl)-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085020", "l": "Cytosolic Neu5Ac translocates to nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428511", "l": "NCK binds ROBO1:SLIT2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201669", "l": "Beta-catenin translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033250", "l": "penicillinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003863", "l": "3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177930", "l": "GAB1 phosphorylation by EGFR kinase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28008", "l": "formaldehyde + H2O2 + L-tryptophan => H2O + N(alpha)-methyl-L-tryptophan + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13842", "l": "[transferrin[Fe(II)2]] + H(+) + NAD(+) => [transferrin[Fe(III)2]] + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873926", "l": "IFNG dimer binds IFNGR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9724685", "l": "IgE binds omalizumab (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39910", "l": "2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose <=> dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53684", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374909", "l": "Metabolism of Noradrenaline (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034791", "l": "isobutylamine N-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052829", "l": "inositol-1,3,4-trisphosphate 1-phosphatase activity"}, {"i": "REACT:R-HSA-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617825", "l": "TRAF3IB1 recruits IFT20 to the IFT B complex from the Golgi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38981", "l": "1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+) => 1-octadecanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62311", "l": "(+)-premalbrancheamide + chloride + FAD + 2 H(+) <=> (+)-malbrancheamide B + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48422", "l": "CMP + ganglioside GM1 (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E))"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420883", "l": "Opsins act as GEFs for G alpha-t (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675656", "l": "EDA:EDAR binds EDARADD (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237102", "l": "Transamination of MOB to methionine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23959", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22491", "l": "S-(hydroxymethyl)glutathione <=> formaldehyde + glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57212", "l": "dGTP + methylglyoxal = N(2)-(1-hydroxy-2-oxopropyl)-dGTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59179", "l": "ADP + L-serine <=> AMP + H(+) + O-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016287", "l": "glycerone-phosphate O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64222", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + taurine => H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714483", "l": "RAC2 translocates to the ER membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047347", "l": "aldose-1-phosphate nucleotidyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55901", "l": "chloride + FADH2 + L-tryptophan + O2 => 6-chloro-L-tryptophan + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607725", "l": "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014454", "l": "RHOG translocates to the ER membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10879", "l": "4-hydroxybenzoate + H(+) <=> CO2 + phenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700154", "l": "Active ALK binds SHC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60867", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188002", "l": "Rab5-mediated recruitment of class III PI3K to TLR9 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863858", "l": "SEC22B, CALR, STX4, TAP and TAPBP bind (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22867", "l": "L-lysine <=> D-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004490", "l": "methylglutaconyl-CoA hydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25307", "l": "7,8-dihydroneopterin + phosphate => 7,8-dihydroneopterin 3'-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46796", "l": "2 [Fe(II)-cytochrome b5] + an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944215", "l": "Association of procollagen type XX (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34711", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine = 15-methylhexadecasphing-4-enine + a fatty acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432652", "l": "Nuclear CRY is degraded by the 26S proteasome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35073", "l": "4-methylphenol(out) => 4-methylphenol(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672817", "l": "Active MTORC1 binds the ULK1 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58874", "l": "4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 24-methylidenelophenol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37587", "l": "2-oxoglutarate + D-lysine = 6-amino-2-oxohexanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2467775", "l": "Autocleavage of ESPL1 (Separase) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11399", "l": "5-methyldeoxycytidine 5'-phosphate + ATP <=> 5-methyldeoxycytidine diphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001586", "l": "Gi/o-coupled serotonin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950448", "l": "STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47576", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) = CMP + ganglioside GD1c (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0140414", "l": "phosphopantetheine-dependent carrier activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42906", "l": "H(+) + N(1)-methylguanosine(748) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(748) in 23S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63914", "l": "6-azauridine 5'-phosphate + ADP + H(+) => 6-azauridine + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29414", "l": "glycolate(in) + H(+)(in) <=> glycolate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61541", "l": "ent-kaur-16-en-19-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682026", "l": "MRN bound to shortened telomeres activates ATM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44130", "l": "CoA + hexadecanyl (9E)-octadecenoate => (9E)-octadecenoyl-CoA + hexadecan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36181", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1-O-alkyl-2-acyl-sn-glycerol + CDP-choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53252", "l": "5alpha-cholest-7-en-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = 5alpha-cholestan-7-oxo-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2214330", "l": "Cleavage of collagen VII NC2 region by BMP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424485", "l": "Release of p-PLCG1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42508", "l": "6-acetamido-2-oxohexanoate + H2O + NAD(+) = 5-acetamidopentanoate + CO2 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18761", "l": "a 1,2-diacyl-sn-glycerol + H2O = a fatty acid + a monoacylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42348", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35716", "l": "(2S,3S)-versiconal hemiacetal acetate + H2O => (2S-3S)-versiconal hemiacetal + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45880", "l": "3-methylundecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174931", "l": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61554", "l": "gibberellin A12 aldehyde + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => ent-7alpha-hydroxykaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807214", "l": "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109822", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0015214", "l": "pyrimidine nucleoside transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61237", "l": "H2O + L-methionine + O2 => 4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35893", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2473584", "l": "Collagen type III degradation by MMP15 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34389", "l": "beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + H(+) + UDP => beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + UDP-alpha-D-galactofuranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60227", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62164", "l": "beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + H2O = D-glucosamine + N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008240", "l": "tripeptidyl-peptidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "77.690207805941611", "identifiers": [{"i": "GO:0015299", "l": "solute:proton antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50694", "l": "ADP + alpha-maltose 1-phosphate + H(+) => ADP-alpha-D-glucose + alpha-D-glucose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32393", "l": "(1R,4R)-dihydrocarvone + H(+) + NADH => (1R,2R,4R)-dihydrocarveol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428625", "l": "Vesicular inhibitory amino acid transport (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24507", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 <=> 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13723", "l": "H(+) + testolate => H2O + testololactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43639", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10687", "l": "H2O + O-phospho-L-tyrosyl-[protein] <=> L-tyrosyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6789092", "l": "NOX2 generates superoxide anion from oxygen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37832", "l": "(S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 => 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55538", "l": "a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+) => an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35761", "l": "aflatoxin B1 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase] => 8-O-methylsterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003948", "l": "N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23868", "l": "(1-hydroxycyclohexan-1-yl)acetyl-CoA = acetyl-CoA + cyclohexanone"}, {"i": "EC:4.1.3.35", "l": "\"(1-hydroxycyclohexan-1-yl)acetyl-CoA lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33906", "l": "H2O + O2 + pseudooxynicotine <=> 4-oxo-4-(pyridin-3-yl)butanal + H2O2 + methylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58061", "l": "2-sulfinoacetaldehyde + H2O => acetaldehyde + H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40071", "l": "2-aminoprop-2-enoate + H2O = NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794353", "l": "NRXNs binds MUNC18 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26135", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55293", "l": "pseudouridine(54) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55506", "l": "(5S,10S)-(9R)-7-drimene-11,12-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5S,9S,10S)-drim-7-en-11-ol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264997", "l": "Oxidation of cysteine to cystine in Proinsulin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12859", "l": "L-glutamate => (2S,3S)-3-methyl-L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50186", "l": "N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28204", "l": "2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin] => 2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34169", "l": "2,6-dihydroxypyridine + 4-(methylamino)butanoate + H(+) => 2,6-dihydroxypseudooxynicotine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17098", "l": "3-phenylpyruvate => enol-phenylpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25779", "l": "scyllo-inosose <=> scyllo-inosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28795", "l": "2 a Fe(II)-siderophore + H(+) + NADP(+) = 2 a Fe(III)-siderophore + NADPH"}, {"i": "EC:1.16.1.9", "l": "\"Ferric-chelate reductase (NADPH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35717", "l": "(2S-3S)-versiconal hemiacetal + acetate + H(+) => (2S,3S)-versiconal hemiacetal acetate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57497", "l": "2-methylcitrate => 2-methyl-cis-aconitate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.18.6", "l": "\"4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45954", "l": "H(+) + N(4)-(beta-D-glucosyl)-L-asparaginyl-[protein] + UDP => L-asparaginyl-[protein] + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30409", "l": "oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin] => hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388503", "l": "Oxytocin receptor bind oxytocin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28205", "l": "2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate <=> 2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4086216", "l": "Collagen type VII binds integrin alpha2beta1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-210444", "l": "L-Glutamate loading of synaptic vesicle (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16461", "l": "ATP + H2O + urate(in) = ADP + H(+) + phosphate + urate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621370", "l": "SYK autophosphorylates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786190", "l": "CMBL hydrolyses OM to OLMS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42755", "l": "pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.61"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664850", "l": "ATM binds PEX5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37208", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16622", "l": "dihydrosanguinarine + H(+) + O2 => H2O2 + sanguinarine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2870221", "l": "E-selectin binds E-selectin ligand (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868236", "l": "BAR domain proteins recruit dynamin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "81.790986234327661", "identifiers": [{"i": "GO:0070569", "l": "uridylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2214330", "l": "Cleavage of collagen VII NC2 region by BMP1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55783", "l": "all-trans-5,6-epoxyretinoate + UDP-alpha-D-glucuronate <=> all-trans-5,6-epoxyretinoyl-1-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20406", "l": "H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate => (2S,6S)-2,6-diaminoheptanedioate + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14731", "l": "D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51187", "l": "1-octadecanoyl-sn-glycero-3-phosphoserine + H2O <=> H(+) + octadecanoate + sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017151", "l": "DEAD/H-box RNA helicase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159868", "l": "Furin cleaves pro-factor VII to factor VII (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10610", "l": "(E)-4-coumarate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (E)-cinnamate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66603", "l": "2 dopamine + O2 <=> 2 dopamine quinone + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26537", "l": "3-hydroxypropanoate + ATP + CoA <=> 3-hydroxypropanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47109", "l": "cholate + taurine => H2O + taurocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875568", "l": "RAPGEF1 activates RAP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15134", "l": "H2O + L-glutamate + NAD(+) => 2-oxoglutarate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218820", "l": "Src kinases phosphorylate VAV (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14936", "l": "H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] <=> N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004967", "l": "glucagon receptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0004932", "l": "mating-type factor pheromone receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22856", "l": "(7S)-salutaridinol + acetyl-CoA = (7S)-O-acetylsalutaridinol + CoA"}, {"i": "EC:2.3.1.150", "l": "\"Salutaridinol 7-O-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2509831", "l": "ITPA hydrolyses XTP to XMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018470", "l": "4-hydroxybutaraldehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811427", "l": "COPI vesicle uncoating at the ER (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9017491", "l": "RHOJ GEFs activate RHOJ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10768", "l": "(2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2 = (4S)-2,3-dehydroleucopelargonidin + CO2 + H(+) + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16362", "l": "2-acetolactate => 3-hydroxy-3-methyl-2-oxobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9611277", "l": "P2RY12 binds P2RY12 antagonists (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49161", "l": "1,4-cineole + O2 + reduced [NADPH--hemoprotein reductase] => 2-exo-hydroxy-1,4-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59252", "l": "(E)-3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate = (E)-3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23597", "l": "H2O + 2 NAD(+) + UDP-alpha-D-glucose => 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41164", "l": "1-O-hexadecyl-2-amino-sn-glycerol + ATP => 1-O-hexadecyl-2-desoxy-2-amino-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112703", "l": "PTPN11 is phosphorylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46809", "l": "[trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine => [trehalose-6-phosphate synthase]-S-methyl-L-cysteine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45553", "l": "H2O + N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-tetradecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42919", "l": "adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161293", "l": "Tropoelastin forms aggregate globules (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102286", "l": "ornithine N-delta-acetyltransferase activity"}, {"i": "MetaCyc:RXN-12667"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61029", "l": "itaconate + L-cysteinyl-[protein] => S-(2,3-dicarboxypropyl)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26046", "l": "acetyl-CoA + N-acetylneuraminate <=> CoA + N-acetyl-9-O-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032358", "l": "oxidized pyrimidine DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17167", "l": "diphosphate + dTDP-D-galactose => alpha-D-galactose 1-phosphate + dTTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112392", "l": "Resumption of elongation after recovery from pausing (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113402", "l": "Formation of DSIF:NELF:early elongation complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-917700", "l": "MVB Vesicle Formation (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28382", "l": "H2O + N(6)-(6-phospho-D-fructosyl)-L-lysine = D-glucose 6-phosphate + L-lysine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008458", "l": "carnitine O-octanoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53171", "l": "H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38083", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850818", "l": "SPINK9 binds KLK5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033476", "l": "Dimerization of FGFR3 point mutants with enhanced kinase activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8957241", "l": "TP73 tetramer translocates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37439", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate = a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48130", "l": "(2E,6E)-farnesyl phosphate + H(+) + phosphate => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0043175", "l": "RNA polymerase core enzyme binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944257", "l": "Association of procollagen type XXIV (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814678", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29603", "l": "benzoyl-CoA + H2O + oxidized 2[4Fe-4S]-[ferredoxin] = 4-hydroxybenzoyl-CoA + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]"}, {"i": "EC:1.1.7.1", "l": "\"4-hydroxybenzoyl-CoA reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12658", "l": "a (2S)-2-methylacyl-CoA => a (2R)-2-methylacyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-83660", "l": "Membrane-anchored TNF-alpha binds TNFR1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607004", "l": "Soluble PROCR binds PRTN3:CD177 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204861", "l": "Interaction of Tie2 and Shc1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.-", "l": "\"With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173115", "l": "Formation of Pre-Integration Complex (PIC) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70486", "l": "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981931", "l": "RAC1 and CDC42 activate PAK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31669", "l": "dTDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate => 2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9678925", "l": "NR3C1 binds NR3C1 agonists (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193964", "l": "CYP21A2 21-hydroxylates PROG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879910", "l": "JAK2 is phosphorylated, activated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45065", "l": "H2O + N-hexadecanoylethanolamine => ethanolamine + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38664", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) => a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29795", "l": "ATP(in) + H2O(in) + Zn(2+)(out) = ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in)"}, {"i": "EC:7.2.2.20", "l": "\"ABC-type Zn(2+) transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20829", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38833", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009072", "l": "STAT3 phosphorylation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22410", "l": "(2E)-geranyl diphosphate + diphosphate => dimethylallyl diphosphate + isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018798", "l": "gallate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66590", "l": "a 5-methylcytidine in 26S rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in 26S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "72.438504002572699", "identifiers": [{"i": "GO:0015926", "l": "glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54299", "l": "GTP + L-tyrosyl-[protein] <=> diphosphate + O-(5'-guanylyl)-L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50439", "l": "prostaglandin H1 <=> prostaglandin E1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635927", "l": "ATF4 and a CEBP protein bind the TRIB3 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41023", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + octadecanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-octadecanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047844", "l": "deoxycytidine deaminase activity"}, {"i": "EC:3.5.4.14"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786034", "l": "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014293", "l": "RAC2 GDIs block activation of RAC2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27861", "l": "2',3'-cyclic GMP + H2O <=> 3'-GMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200143", "l": "AKT phosphorylates AKT1S1 (PRAS40) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209792", "l": "N-acetylation of serotonin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23786", "l": "(S)-1-pyrroline-5-carboxylate + a quinol + H(+) => a quinone + L-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111930", "l": "Adenylate cyclase produces cAMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32228", "l": "(6R)-NADPHX => (6S)-NADPHX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141423", "l": "Binding of the MCC complex to the APC/C complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12933", "l": "L-fuculose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate"}, {"i": "EC:4.1.2.17", "l": "\"L-fuculose-phosphate aldolase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034946", "l": "3-isopropylbut-3-enoyl-CoA thioesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44013", "l": "(9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA => (9Z)-hexadecenoyl-(Kdo)2-lipid IVA + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16518", "l": "(R)-1-aminopropan-2-ol + NAD(+) => aminoacetone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948027", "l": "RNASEs bind bacterial phospholipids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606273", "l": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852362", "l": "GTSE1 binds CDKN1A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.55", "l": "\"Pitrilysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983259", "l": "Kinesins move along microtubules consuming ATP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41813", "l": "(2E)-butenoyl-[ACP] + H(+) + NADPH => butanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30114", "l": "Fe(III)-enterobactin + H(+) + 3 H2O <=> Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851888", "l": "MET binds SHC1-2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62538", "l": "2 [Fe(III)cytochrome c] + dihydrodigoxigenin => 2 [Fe(II)cytochrome c] + digoxigenin + 3 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784735", "l": "PCSK9:LDLR bind to Clathrin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0032813", "l": "tumor necrosis factor receptor superfamily binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5140741", "l": "WNT5A binds FZD and ROR receptors (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47232", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22286", "l": "CO2 + NH4(+) + putrescine => 2 H(+) + H2O + N-carbamoylputrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37465", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004512", "l": "inositol-3-phosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430135", "l": "p-SLP-76 binds ADAP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13505", "l": "choline + O2 = betaine aldehyde + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44604", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683831", "l": "CCDC59 binds TTF1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39528", "l": "(2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH => (17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15370", "l": "2,3-dihydroxybenzoate + O2 => 2-carboxy-cis,cis-muconate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75187", "l": "TRAIL:TRAIL receptor trimers bind FADD (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634219", "l": "NUP93 recruits the Nup62 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938217", "l": "RUNX1 binds the SWI/SNF complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54965", "l": "hexadecanoyl-[ACP] + phosphate => hexadecanoyl phosphate + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983138", "l": "Transport of MHC heterotrimer to ER exit site (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164943", "l": "Nef mediated activation of the T-cell receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52664", "l": "a short-chain (3S)-3-hydroxyacyl-CoA = a short-chain (2E)-enoyl-CoA + H2O"}, {"i": "EC:4.2.1.150", "l": "\"Short-chain-enoyl-CoA hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47627", "l": "cis-3-hydroxy-L-proline <=> 1-pyrroline-2-carboxylate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55961", "l": "4-(trimethylamino)butanoate + ATP + CoA => AMP + diphosphate + gamma-butyrobetainyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33631", "l": "ATP + CoA + octanoate = AMP + diphosphate + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429497", "l": "SLP-76 stimulates PLC gamma 2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66292", "l": "an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13568", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol <=> 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52699", "l": "a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-galactose <=> a 1,2-diacyl-3-O-[alpha-D-galactopyranosyl-(1->2)-alpha-D-glucopyranosyl]-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62236", "l": "a cytidine(6-4)cytidine in DNA = a cytidine dimer in DNA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19339", "l": "2 H(+) + hyponitrous acid + 2 NADH => 2 hydroxylamine + 2 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57130", "l": "(4-hydroxyphenyl)acetaldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin] => H2O + 2 oxidized [azurin] + tyramine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004331", "l": "fructose-2,6-bisphosphate 2-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24940", "l": "(R)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+) => D-glutamate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58848", "l": "(6E)-8-hydroxygeraniol + NAD(+) = (6E)-8-hydroxygeranial + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844619", "l": "AIM2 binds dsDNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055042", "l": "5-valerolactone hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5336443", "l": "LIN7, CASK and APBA1 bind (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42710", "l": "N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine => guanosine(46) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857555", "l": "EGFR phosphorylates GPNMB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30639", "l": "(R)-glycerate + GDP-alpha-D-mannose = (2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+)"}, {"i": "EC:2.4.1.269", "l": "\"Mannosylglycerate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62914", "l": "1-(3,4,5-trihydroxy-7-methoxynaphthalen-2-yl)propan-2-one + CO2 + NAD(+) => H(+) + NADH + O2 + toralactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672969", "l": "Phosphorylation of RAF (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46821", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161948", "l": "Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937118", "l": "RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the MIR27A gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19835", "l": "(6S)-5,6,7,8-tetrahydrofolate + formate + H(+) => (6S)-10-formyltetrahydrofolate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59339", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene + A <=> AH2 + demethylspheroidene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47684", "l": "[(1->2)-beta-D-glucosyl](n) + phosphate = [(1->2)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate"}, {"i": "EC:2.4.1.333", "l": "\"1,2-beta-oligoglucan phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51925", "l": "AH2 + menaquinone-9 => A + beta-dihydromenaquinone-9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30456", "l": "(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O => (-)-geosmin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5082356", "l": "HSF1-mediated gene expression (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632914", "l": "TP53 binds the GLS2 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948757", "l": "AKT phosphorylates MKRN1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199839", "l": "AKT can phosphorylate RSK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047862", "l": "diisopropyl-fluorophosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660752", "l": "USP9X deubiquitinates Ub-SNCA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25690", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) = CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate"}, {"i": "EC:2.7.7.67", "l": "\"CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41010", "l": "(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin <=> 6-linalyl-2-O,3-dimethylflaviolin + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54952", "l": "ATP + CoA + nonanoate = AMP + diphosphate + nonanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114352", "l": "Sequestration of tBID by BCL-2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694445", "l": "nsp16 binds nsp10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3132759", "l": "TCN1 binds Cbl (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42625", "l": "(Z)-3-ureidoacrylate + H(+) + H2O => (Z)-3-aminoacrylate + CO2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47923", "l": "ganglioside GM2 (d18:1(4E)/18:0) + H2O <=> ganglioside GA2 (d18:1(4E)/18:0) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36226", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + H(+) + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56590", "l": "an aldehyde + hydrogen cyanide => a monosubstituted aliphatic (S)-hydroxynitrile"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682026", "l": "MRN bound to shortened telomeres activates ATM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46014", "l": "a quinol + oxaloacetate => (S)-malate + a quinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433415", "l": "Activation of RAC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46596", "l": "NADPH + O2 + rifampicin = 2'-N-hydroxyrifampicin + H2O + NADP(+)"}, {"i": "RHEA:48988", "l": "NADH + O2 + rifampicin = 2'-N-hydroxyrifampicin + H2O + NAD(+)"}, {"i": "EC:1.14.13.211", "l": "\"Rifampicin monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44687", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047648", "l": "alkylamidase activity"}, {"i": "MetaCyc:ALKYLAMIDASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31998", "l": "(2E,6E)-farnesyl diphosphate <=> 7-epi-sesquithujene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9663511", "l": "BIL binds GSTA1, FABP1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052715", "l": "mannosyl-diinositol phosphorylceramide phospholipase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621010", "l": "HOXB1 activates HOXA2 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805546", "l": "Keratin type I binds keratin type II (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11685", "l": "methylarsonous acid + S-adenosyl-L-methionine => dimethylarsinate + 2 H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944457", "l": "MAF1 translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876472", "l": "NPC2 binds CHOL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15523", "l": "CoA + H(+) + N-tetradecanoylglycyl-[protein] => N-terminal glycyl-[protein] + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49306", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + N-acetyl-alpha-D-galactosamine => a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607724", "l": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58736", "l": "H2O + TTP = 5-methyl-UMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16770", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 1-phosphate => (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625510", "l": "FOXO1 and p-2S-SMAD2/3:SMAD4 bind MSTN gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33123", "l": "all-trans-heptaprenyl diphosphate = (R)-tetraprenyl-beta-curcumene + diphosphate"}, {"i": "EC:4.2.3.130", "l": "\"Tetraprenyl-beta-curcumene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-984671", "l": "Chromokinesins form dimers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32520", "l": "(2E)-geranyl diphosphate + S-adenosyl-L-methionine => (E)-2-methylgeranyl diphosphate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52888", "l": "N-phenylhydroxylamine + NADP(+) = H(+) + NADPH + nitrosobenzene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52455", "l": "16alpha-hydroxyestrone + UDP-alpha-D-glucuronate <=> 16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50595", "l": "13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) <=> 15-oxoprostaglandin F1alpha + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15065", "l": "H2O + N(4)-benzoylagmatine = agmatine + benzoate"}, {"i": "EC:3.5.1.40", "l": "\"Acylagmatine amidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981610", "l": "Neuroglobin binds oxygen (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3296244", "l": "SUCNR1 binds SUCCA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6794346", "l": "NRXNs bind NLGNs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2395517", "l": "NADPH transfers electrons to FDXR (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603419", "l": "Activated NTRK3 binds SRC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29398", "l": "H2O + UTP <=> diphosphate + H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951595", "l": "CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0042879", "l": "aldonate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64189", "l": "an N-(fatty acyl)-L-tyrosine + H2O => a fatty acid + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950063", "l": "IL12RB2 binds JAK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618863", "l": "CaMKK binds activated calmodulin in the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56949", "l": "pyruvate + UTP => H(+) + phosphoenolpyruvate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49832", "l": "a fatty aldehyde + H2O + NAD(+) = a fatty acid + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606839", "l": "Steryl sulfatase hydrolyses sulfate from steroid sulfates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180725", "l": "Rev associates with B23 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17485", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990640", "l": "inositol-2,4,5-triphosphate 5-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44048", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = 8,9-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035484", "l": "CysS248-MPST:TXN2 dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46352", "l": "(2E)-decenoyl-CoA + H2O = 3-hydroxydecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27591", "l": "(R)-pantoate + ATP + beta-alanine => (R)-pantothenate + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63293", "l": "N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1248) in human 18S rRNA + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389756", "l": "AKT interacts and phosphorylates Cot (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848124", "l": "PTK6 phosphorylates STAT3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046554", "l": "malate dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35475", "l": "(1'S,5'S)-5'-hydroxyaverantin + NAD(+) = (S)-5'-oxoaverantin + H(+) + NADH"}, {"i": "RHEA:35479", "l": "(1'S,5'R)-5'-hydroxyaverantin + NAD(+) = (S)-5'-oxoaverantin + 2 H(+) + NADH"}, {"i": "EC:1.1.1.352", "l": "\"5'-hydroxyaverantin dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874849", "l": "CREBRF binds CREB3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54195", "l": "L-lysyl-[protein] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14376", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22430", "l": "2 H2O + isopenicillin N => N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55291", "l": "tetradecan-1-ol + tetradecanoyl-CoA <=> CoA + tetradecanyl tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53702", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12374", "l": "4-oxohex-2-enedioate + H(+) => 2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390641", "l": "ADRA1A,B,D bind ADR,NAd (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389862", "l": "Conversion of glyoxylate to oxalate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70692", "l": "ornithine => putrescine + CO2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "80.155824608458104", "identifiers": [{"i": "GO:0005337", "l": "nucleoside transmembrane transporter activity"}, {"i": "REACT:R-HSA-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955844", "l": "RBKS phosphorylates ribose to R5P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592314", "l": "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52498", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26429", "l": "ATP + H2O + L-glutamine + UTP <=> ADP + CTP + 2 H(+) + L-glutamate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203700", "l": "eNOS translocation from Golgi to Caveolae (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627106", "l": "SMAC (DIABLO) forms dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13074", "l": "guanosine 3'-diphosphate 5'-triphosphate + H2O => guanosine 3',5'-bis(diphosphate) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209120", "l": "Membrane recruitment of DSH to FZ and AXN to phosphorylated ARR (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49089", "l": "FAD + H(+) + H2O + squalene => FADH2 + hydroxysqualene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52449", "l": "16alpha-hydroxyestrone + UDP-alpha-D-glucuronate => 16alpha-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043429", "l": "2-nonaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31899", "l": "indole + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + indolin-2-one + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.153", "l": "\"Indole-2-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42637", "l": "AH2 + L-cysteine + Mo-molybdopterin => A + H2O + L-alanine + thio-Mo-molybdopterin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030023", "l": "extracellular matrix constituent conferring elasticity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625409", "l": "KLF4 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64086", "l": "2,3,6,8,9-pentahydroxy-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracen-1-one + CO2 => 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202248", "l": "Phosphorylation of PLC-gamma1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40657", "l": "(R)-malyl-CoA + succinate => (R)-malate + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873921", "l": "Binding of STAT1 to p-IFNGR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.-", "l": "\"Peptidyl peptide hydrolases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44262", "l": "4-hydroxy-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + hexadecanoyl-CoA + 2 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21797", "l": "dTDP-beta-L-rhamnose + NADP(+) => dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031432", "l": "titin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41836", "l": "H(+) + hexanoyl-[ACP] + malonyl-[ACP] = 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680262", "l": "SARS coronavirus gRNA:RTC:RNA primer binds RTC inhibitors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14457", "l": "glyoxylate + H2O + pentanoyl-CoA = 3-propylmalate + CoA + H(+)"}, {"i": "EC:2.3.3.12", "l": "\"3-propylmalate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5622129", "l": "FABP5 binds atRA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017098", "l": "sulfonylurea receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781899", "l": "USP13 binds SIAH2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29615", "l": "alpha-maltotriose + beta-maltose = alpha-maltotetraose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54414", "l": "a 3-oxo-Delta(4)-steroid + H(+) + NADPH => a 3-oxo-5beta-steroid + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0071617", "l": "lysophospholipid acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3239014", "l": "MAPKAPK5 phosphorylates TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65516", "l": "5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O = NH4(+) + pre-mycofactocin"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0008252", "l": "nucleotidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46717", "l": "pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399930", "l": "Activation of PAK by Rac1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9017507", "l": "RHOJ binds effectors at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196017", "l": "Dynamin is recruited to the gap junction plaque (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27729", "l": "5-dehydro-4-deoxy-D-glucarate <=> 2-hydroxy-3-oxopropanoate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43186", "l": "H(+) + N(3)-methyluridine(2843) in 25S rRNA + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2843) in 25S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031827", "l": "type 2B serotonin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30552", "l": "acetyl-CoA + beta-D-glucose => 6-O-acetyl-beta-D-glucose + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981621", "l": "Neuroglobin:oxygen dissociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352864", "l": "glucose [extracellular] <=> glucose [cytosol] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785409", "l": "NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60325", "l": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22740", "l": "ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.12"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18994", "l": "(9Z,12Z)-octadecadienoate + O2 => (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20463", "l": "an N,N,N-trimethylornithine lipid + 3 H(+) + 3 S-adenosyl-L-homocysteine => an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + 3 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16662", "l": "fluoride + S-adenosyl-L-methionine => 5'-deoxy-5'-fluoroadenosine + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32985", "l": "2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-1D-myo-inositol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647680", "l": "CASP1 cleaves GSDMD (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10660", "l": "L-seryl-[protein] = D-seryl-[protein]"}, {"i": "EC:5.1.1.16", "l": "\"Protein-serine epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70573", "l": "argininosuccinate <=> fumarate + arginine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805059", "l": "CK2:FACT phosphorylates TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38786", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389919", "l": "Grb2 binds pBTLA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.19"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65913", "l": "3-hydroxy-L-kynurenine + pyruvate => 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.33"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990136", "l": "linoleate 9S-lipoxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12418", "l": "acryloyl-CoA + NH4(+) => beta-alanyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58793", "l": "ATP + Fe(III)-petrobactin(out) + H2O => ADP + Fe(III)-petrobactin(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.99.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418856", "l": "Activation of Rac1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043531", "l": "ADP binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030769", "l": "macrocin O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805103", "l": "AURKA phosphorylates TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804527", "l": "INTL1 binds bacterial glycans (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1640164", "l": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29635", "l": "alpha-maltopentaose + H2O = alpha-D-glucose + alpha-maltotetraose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.162"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5159250", "l": "ATF7IP binds SETDB1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75079", "l": "Formation of AT-AC C complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58279", "l": "6 ATP <=> cyclic hexaadenylate + 6 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23213", "l": "H2O + N-acetyl-beta-alanine => acetate + beta-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39871", "l": "3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042299", "l": "lupeol synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211959", "l": "CYP3A43 6b-hydroxylates TEST (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1254291", "l": "ERBB4s80 binds STAT5A (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-947499", "l": "Exchange of oxygen with sulfur in MoCo (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173740", "l": "Factor B binds to C3(H2O) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62593", "l": "(S)-8-oxocitronellyl enol + NADP(+) => (6E)-8-oxogeranial + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004373", "l": "glycogen (starch) synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3777129", "l": "HDAC3 containing complexes deacetylate histone (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1606273", "l": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25326", "l": "N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine => H(+) + phosphocholine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35532", "l": "cyclo(L-phenylalanyl-L-leucyl) + 2 O2 => albonoursin + 2 H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210292", "l": "Interaction of DAP12 and TREM1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13049", "l": "D-glucuronate = D-fructuronate"}, {"i": "RHEA:27702", "l": "aldehydo-D-galacturonate = keto-D-tagaturonate"}, {"i": "EC:5.3.1.12", "l": "\"Glucuronate isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38116", "l": "(9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol => 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6791016", "l": "SFTPB binds itself (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25347", "l": "D-tyrosyl-tRNA(Tyr) + H2O = D-tyrosine + tRNA(Tyr)"}, {"i": "EC:3.6.1.n1", "l": "\"D-tyrosyl-tRNA(Tyr) hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65388", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602458", "l": "Activation of proMMP10 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59013", "l": "cycloartenol + S-adenosyl-L-methionine => 24-methylenecycloartanol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23653", "l": "N-terminal L-glutaminyl-[peptide] => N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199014", "l": "CD96 binds PVR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0004033", "l": "aldo-keto reductase (NADP) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58197", "l": "H2O + N(6)-acetyl-L-lysyl-[histone] => acetate + L-lysyl-[histone]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692749", "l": "CDC14A,B bind MAPK6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379865", "l": "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592362", "l": "Activation of proMMP7 by MMP3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9677585", "l": "CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33983", "l": "(+)-copalyl diphosphate = diphosphate + miltiradiene"}, {"i": "EC:4.2.3.131", "l": "\"Miltiradiene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159796", "l": "Furin cleaves pro-factor IX to factor IX (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40605", "l": "(9Z,12Z)-octadecadienoate + glycerol + H(+) => 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58497", "l": "choline + H(+) + NADH + O2 => glycolaldehyde + H2O + NAD(+) + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12708", "l": "[protein]-L-beta-isoaspartate + S-adenosyl-L-methionine <=> [protein]-L-beta-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33908", "l": "4-(methylamino)butanoate + H2O + O2 => 4-aminobutanoate + formaldehyde + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014294", "l": "RAC2 binds effectors at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665709", "l": "ERBB2 TMD/JMD heterodimers trans-autophosphorylate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66810", "l": "7 CO2 + 8 CoA + 6 H2O + 11 NADP(+) + wortmanamide A => 5-aminopentanoate + acetyl-CoA + 17 H(+) + 7 malonyl-CoA + 11 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14484", "l": "2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O <=> 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41949", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate => [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008813", "l": "chorismate lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64192", "l": "H2O + N-(9Z-octadecenoyl)-L-lysine = (9Z)-octadecenoate + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602606", "l": "Defective MyD88 does not bind MAL(TIRAP):TLR2/4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70510", "l": "LDH tetramer oxidises LACT to PYR (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682026", "l": "MRN bound to shortened telomeres activates ATM (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32510", "l": "4-isopropenyl-7-methyloxepan-2-one + H2O <=> 6-hydroxy-3-isopropenylheptanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40926", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797553", "l": "Protein 4.1 binds CASK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42523", "l": "uridine(2605) in 23S rRNA <=> pseudouridine(2605) in 23S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708812", "l": "ELAC2 cleaves pre-tRNA to yield 3' trailer (type II tRF or tRF-1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390835", "l": "DRD1,5 bind DA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34033", "l": "acetate + paromamine => 2'-N-acetylparomamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23761", "l": "H(+) + H2 + oxidized coenzyme F420-(gamma-Glu)(n) => reduced coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13993", "l": "(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate"}, {"i": "EC:2.6.1.22", "l": "\"(S)-3-amino-2-methylpropionate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202709", "l": "JAM2 dimerises (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23231", "l": "L-lysine + NADPH + O2 <=> H2O + N(6)-hydroxy-L-lysine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17471", "l": "a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester + apo--[retinol-binding protein] => a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060961", "l": "phospholipase D inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63602", "l": "L-isoleucine + neocasomorphin-(1-5) => H2O + neocasomorphin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48313", "l": "benzoyl-CoA + H(+) + NADPH + O2 => 2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39901", "l": "7-deoxyloganin + H(+) + UDP => 7-deoxyloganetin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46918", "l": "H(+) + juvenile hormone I carboxylate + methanol => H2O + juvenile hormone I"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645220", "l": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3159253", "l": "MMAB transfers adenosyl group from ATP to cob(I)alamin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982617", "l": "CYGB:O2 dissociates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50450", "l": "A + H2O + prostaglandin H3 => AH2 + prostaglandin G3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39533", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+) => 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36868", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65598", "l": "4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34447", "l": "dTDP-6-deoxy-beta-L-talose + NAD(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH"}, {"i": "EC:1.1.1.339", "l": "\"dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51586", "l": "crotonobetainyl-CoA + reduced [electron-transfer flavoprotein] => gamma-butyrobetainyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16689", "l": "D-glucose 6-phosphate + H2O = D-glucose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.68", "l": "\"Ulp1 peptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.115"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665232", "l": "Resistant ERBB2 KD mutants do not bind trastuzumab (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55470", "l": "11,20-dihydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 11-hydroxyferruginol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391372", "l": "GNRHR binds GNRH1,2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37014", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1-acyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77609", "l": "Binding of APOBEC-1 to form editosome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52259", "l": "a 7(1)-hydroxybacteriochlorophyllide c + H2O + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide c + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47734", "l": "5-methylcytidine(1400) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1400) in 16S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28037", "l": "[thioredoxin]-disulfide + dADP + H2O <=> [thioredoxin]-dithiol + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811479", "l": "ING2 recruits EP300 to TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357927", "l": "MLKL oligomerizes  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43448", "l": "H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863973", "l": "Fusion of ERC and phagosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33200", "l": "butan-1-ol + NAD(+) => butanal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694436", "l": "MIA2 and MIA3 dissociate from procollagen VII vesicle (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429860", "l": "DCP1-DCP2 complex decaps mRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11478", "l": "glycerol + phosphate => glycerol 1-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22453", "l": "[phosphate](n+1) + n H2O => n H(+) + (n+1) phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38530", "l": "1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21271", "l": "(R)-canadine + 2 NADP(+) <=> berberine + H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44339", "l": "an L-alpha-amino acid + ATP + L-arginine <=> ADP + H(+) + L-arginyl-L-alpha-amino acid + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65872", "l": "1,17beta-dihydroxyandrostan-3-one + A = 17beta-hydroxyandrostan-1,3-dione + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174171", "l": "Association of Cyclin A with the APC/C (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8873850", "l": "STARD5 binds DCA, LCA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8850945", "l": "Casein kinase II phosphorylates PTEN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46298", "l": "6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.22.5", "l": "\"Deoxyribonuclease X\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5622134", "l": "CRABP1 binds atRA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033991", "l": "aldos-2-ulose dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18361", "l": "dolichyl D-xylosyl phosphate + L-seryl-[protein] = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + dolichyl phosphate + H(+)"}, {"i": "EC:2.4.2.33", "l": "\"Dolichyl-xylosyl-phosphate--protein xylosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381496", "l": "Formation of the IGF:IGFBP3:ALS complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49029", "l": "(-)-bursehernin + O2 + reduced [NADPH--hemoprotein reductase] => (-)-5'-demethylyatein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25523", "l": "an acyl-CoA + pseudotropine <=> CoA + H(+) + O-acylpseudotropine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57876", "l": "uridine(54) in tRNA = pseudouridine(54) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53248", "l": "cholesta-5,7-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxycholest-5-en-7-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12701", "l": "[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-triphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-triphosphate"}, {"i": "EC:1.17.4.2", "l": "\"Ribonucleoside-triphosphate reductase (thioredoxin)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31105", "l": "folate + H(+) + NADPH => 7,8-dihydrofolate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9749197", "l": "ORC1 binds to H4K20me2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11568", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP = 5-methyldeoxycytidine 5'-phosphate + 7,8-dihydrofolate"}, {"i": "EC:2.1.1.54", "l": "\"Deoxycytidylate C-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61968", "l": "2 [Fe(II)-cytochrome b5] + a 1-O-(9Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a 1-O-(1Z,9Z-octadecadienyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.69", "l": "\"Protein C (activated)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48495", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + UDP-alpha-D-galactose <=> 1,2-di-(9Z,12Z-octadecadienoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60656", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-2,3-cyclic phosphate + choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62305", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine => (+)-premalbrancheamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11309", "l": "acetyl-CoA + ATP + hydrogencarbonate => ADP + H(+) + malonyl-CoA + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57556", "l": "(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + zealexin A1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32654", "l": "erythromycin D + S-adenosyl-L-methionine <=> erythromycin B + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20807", "l": "2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) <=> H(+) + hydrogencarbonate + NADH + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198508", "l": "malate + NAD+ <=> oxaloacetate + NADH + H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38076", "l": "2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35501", "l": "glycyrrhetinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 11-oxo-beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12040", "l": "(S)-3-(imidazol-5-yl)lactate + NADP(+) = 3-(imidazol-5-yl)pyruvate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10903", "l": "an aromatic L-alpha-amino acid + glyoxylate <=> an aromatic oxo-acid + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56743", "l": "globoside Gb3Cer + UDP-alpha-D-galactose <=> GalGb3Cer + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-532549", "l": "MPI isomerises Fru6P to Man6P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161949", "l": "HXA3/B3 is hydrolysed to TrXA3/B3 by HXEH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33621", "l": "AMP + diphosphate + tetradecanoyl-CoA => ATP + CoA + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48186", "l": "(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6795473", "l": "PDPK1 phosphorylates SGK1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-482770", "l": "Release of platelet secretory granule components (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61484", "l": "a cytidine in rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004438", "l": "phosphatidylinositol-3-phosphatase activity"}, {"i": "REACT:R-HSA-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10556", "l": "D-glyceraldehyde 3-phosphate + L-arginine = H(+) + N(2)-(2-carboxyethyl)-L-arginine + phosphate"}, {"i": "EC:2.5.1.66", "l": "\"N(2)-(2-carboxyethyl)arginine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66724", "l": "(S)-lactate + L-phenylalanine = H2O + N-[(S)-lactoyl]-L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44436", "l": "a 1,2-diacylglycerol + a 1-acylglycerol = a triacylglycerol + glycerol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046592", "l": "polyamine oxidase activity"}, {"i": "MetaCyc:POLYAMINE-OXIDASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21481", "l": "2-furoyl-CoA + A + H2O => 5-hydroxy-2-furoyl-CoA + AH2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50338", "l": "H(+) + H2O + omega-hydroxy-triacontanoate + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + triacontanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2509831", "l": "ITPA hydrolyses XTP to XMP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203613", "l": "depalmitoylation of eNOS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52045", "l": "mogrol + UDP-alpha-D-glucose => H(+) + mogroside IE + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672978", "l": "RAF phosphorylates MAP2K dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59729", "l": "(2R)-ethylmalonyl-CoA => (2S)-ethylmalonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047478", "l": "aspartate-ammonia ligase (ADP-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58561", "l": "15alpha-stemmadenine intermediate II + NADP(+) => 15alpha-stemmadenine intermediate I + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19800", "l": "1D-myo-inositol 1,4,5-trisphosphate + H2O <=> 1D-myo-inositol 1,4-bisphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865711", "l": "RAG1:RAG2 recombinase binds immunoglobulin kappa locus in a BRWD1-dependent manner (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39121", "l": "(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2 => (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849428", "l": "PTPN1 binds PTK6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174551", "l": "Formation of alternative pathway C5 convertase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141310", "l": "FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26514", "l": "cyclohexan-1,2-dione + H2O = 6-oxohexanoate + H(+)"}, {"i": "EC:3.7.1.11", "l": "\"Cyclohexane-1,2-dione hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050581", "l": "D-mannitol oxidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044024", "l": "histone kinase activity (H2A-S1 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42050", "l": "acetoacetyl-CoA + H(+) + NADH => 3-hydroxybutanoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799350", "l": "Exocytosis of specific granule membrane proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55190", "l": "5-methyl-2-thiouridine(54) in tRNA + AMP + diphosphate => 5-methyluridine(54) in tRNA + ATP + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047268", "l": "galactinol-raffinose galactosyltransferase activity"}, {"i": "RHEA:20776", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose = myo-inositol + stachyose"}, {"i": "EC:2.4.1.67", "l": "\"Galactinol--raffinose galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067646", "l": "JAK1,JAK2,(TYK2) bind IL6ST (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944250", "l": "Association of procollagen type XXV (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001081", "l": "(1->4)-beta-D-galactan binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13403", "l": "(2Z,6E)-farnesol => (2E,6E)-farnesol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026531", "l": "p-Y817 of p-5Y-NTRK2 recruits PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016936", "l": "galactoside binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44439", "l": "a 1,2-diacylglycerol + a 1-acylglycerol <=> a triacylglycerol + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204392", "l": "Basigin binds MCT1, MCT3 and MCT4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58913", "l": "ATP + H2O + iron(III) dicitrate(out) => ADP + H(+) + iron(III) dicitrate(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25912", "l": "A + H2O + quinolin-5-ol = 5-hydroxyquinolin-2(1H)-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788623", "l": "p-Y-STATs translocate to nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41474", "l": "H(+) + H2O + oryzalexin D + oxidized [NADPH--hemoprotein reductase] => ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72663", "l": "De novo formation of eIF2:GTP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24676", "l": "ADP + CMP + H(+) => ATP + cytidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18248", "l": "3'-dephospho-CoA + ATP <=> ADP + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605056", "l": "Expression of SREBF1 (SREBP1) regulated by NR1H2 or NR1H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.23"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36996", "l": "(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53272", "l": "5-dehydro-L-gluconate = keto-D-tagaturonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112755", "l": "SOCS3 binds IL6ST (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34342", "l": "22R-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (20R,22R)-20,22-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008972", "l": "phosphomethylpyrimidine kinase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "65.48928698272745", "identifiers": [{"i": "GO:0008483", "l": "transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55633", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62571", "l": "H2O + S-benzyl-L-cysteinylglycine <=> glycine + S-benzyl-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981926", "l": "RAC1 and CDC42 activate PAK3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202307", "l": "Change of PKC theta conformation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36610", "l": "2-oxoglutarate + L-arginine + O2 <=> (2S,3S)-hydroxyarginine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33212", "l": "1,4-dihydroxy-2-naphthoate + all-trans-heptaprenyl diphosphate + H(+) => 2-demethylmenaquinol-7 + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661517", "l": "LUBAC comlex binds OTULIN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5606996", "l": "Soluble PROCR binds activated protein C (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928656", "l": "gamma-secretase cleaves EPHB2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975040", "l": "KRAB-ZNF / KAP Interaction (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15931", "l": "CO2 + N-(hydroxymethyl)urea + 2 NH4(+) => 2 H(+) + 2 H2O + methylenediurea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21375", "l": "H(+) + H2O + urethane <=> CO2 + ethanol + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29568", "l": "2 chloride(in) + H(+)(out) => 2 chloride(out) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55648", "l": "2-oxoglutarate + O2 + validoxylamine A = CO2 + H(+) + succinate + validoxylamine B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12928", "l": "D-erythrose 4-phosphate + L-lysyl-[protein] <=> H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626848", "l": "S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54750", "l": "AMP + diphosphate + L-firefly luciferyl-CoA => ATP + CoA + firefly L-luciferin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8934446", "l": "Activated PKC phosphorylates SHC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54225", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphocholine => 2-(prostaglandin E2)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26211", "l": "acetaldehyde + glycine => L-allo-threonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69074", "l": "Formation of Processive Complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31757", "l": "3-oxo-5,6-dehydrosuberyl-CoA semialdehyde => 2-oxepin-2(3H)-ylideneacetyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000137", "l": "CUBN:AMN transports extracellular CBLIF:Cbl to endosome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19485", "l": "sphing-4-enine + UDP-alpha-D-galactose = beta-D-galactosyl-(1<->1)-sphing-4-enine + H(+) + UDP"}, {"i": "EC:2.4.1.23", "l": "\"Sphingosine beta-galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-532549", "l": "MPI isomerises Fru6P to Man6P (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102077", "l": "oleamide hydrolase activity"}, {"i": "RHEA:26506", "l": "(9Z)-octadecenamide + H2O = (9Z)-octadecenoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682010", "l": "ATG10:ATG12 binds ATG5 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-443831", "l": "14-3-3-zeta binds Raf1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65122", "l": "L-glutamate + S-[(2E,6E,10E)-geranylgeranyl]-L-cysteinylglycine => H2O + S-[(2E,6E,10E)-geranylgeranyl]-L-glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9011543", "l": "DCA binds PDK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23967", "l": "(E)-coniferaldehyde + H2O + NADP(+) <=> (E)-ferulate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696547", "l": "STAMBPL1 is a deubiquitinase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24057", "l": "a myo-inositol phosphate + H2O => myo-inositol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30383", "l": "(2E,6E)-farnesyl diphosphate = (-)-7-epi-alpha-selinene + diphosphate"}, {"i": "EC:4.2.3.86", "l": "\"7-epi-alpha-selinene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34922", "l": "thiamine(in) <=> thiamine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696605", "l": "USP12, USP26 deubiquitinate AR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22352", "l": "H(+) + L-lysine = cadaverine + CO2"}, {"i": "EC:4.1.1.18", "l": "\"Lysine decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046567", "l": "aphidicolan-16 beta-ol synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5578965", "l": "TNRC6A binds AGO2:miRNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798489", "l": "S100A7 or S100A7A binds Zn2+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008838", "l": "diaminopropionate ammonia-lyase activity"}, {"i": "EC:4.3.1.15", "l": "\"Diaminopropionate ammonia-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66291", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-D-mannosyl-alpha-1->6-inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35696", "l": "(3S)-versiconol acetate + NADP(+) => (2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1362485", "l": "GHBP binds GH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64334", "l": "AMP + diphosphate + nicotinyl-CoA => ATP + CoA + nicotinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53137", "l": "(3beta,5alpha,17beta)-3-hydroxy-androstan-17-yl sulfate + NADP(+) => 5alpha-dihydrotestosterone sulfate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42439", "l": "L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein] <=> L-ascorbate 6-phosphate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12443", "l": "H2O + L-saccharopine + NAD(+) <=> 2-oxoglutarate + H(+) + L-lysine + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1640164", "l": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018469", "l": "myrtenal dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63390", "l": "2 AH2 + Fe(II)-heme a => 2 A + Fe(II)-heme o + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43694", "l": "AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] => ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870465", "l": "RGGT binds the RAB-binding subunit (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205649", "l": "p62 links damaged mitochondria to LC3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033560", "l": "folate reductase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030586", "l": "[methionine synthase] reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64930", "l": "dAMP + H(+) + phosphate => dADP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15319", "l": "2-deoxy-D-glucose + an alcohol => a 2-deoxy-alpha-D-glucoside + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375160", "l": "NCAM1 binds to ATP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57913", "l": "5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+) => H(+) + L-glutaminyl-tRNA(Gln) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977301", "l": "Histidine is decarboxylated to histamine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174119", "l": "Free APC/C phosphorylated by Plk1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32158", "l": "7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine <=> adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "72.438504002572699", "identifiers": [{"i": "GO:0042277", "l": "peptide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58455", "l": "N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41222", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186765", "l": "PLC-gamma binds to the active receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003688", "l": "DNA replication origin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49323", "l": "all-trans-violaxanthin <=> (5R,6S)-5,6-epoxi-capsanthin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48214", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + N-acetyl-alpha-D-galactosamine => a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.45", "l": "\"Aromatic aldoxime N-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981931", "l": "RAC1 and CDC42 activate PAK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062078", "l": "TSC1-TSC2 complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34669", "l": "20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine => C30 botryococcene + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008668", "l": "(2,3-dihydroxybenzoyl)adenylate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9633044", "l": "ESR binds STRN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853745", "l": "RET binds GFRA1,GFRA3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72180", "l": "Cleavage of mRNA at the 3'-end (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59999", "l": "3-phenylpropanoate + H(+) + oxidized [electron-transfer flavoprotein] <=> (E)-cinnamate + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168640", "l": "Ubiquitinated IkB is degraded (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12880", "l": "acetylacetone + O2 <=> acetate + H(+) + methylglyoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141046", "l": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035237", "l": "corazonin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10673", "l": "cyclobutadithymidine in DNA => a thymidine dimer in DNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35849", "l": "ADP + H(+) + sphing-4-enine 1-phosphate => ATP + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49590", "l": "D-erythrulose 4-phosphate => L-erythrulose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59617", "l": "beta-alanyl-L-arginine + H2O => beta-alanine + L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190260", "l": "FGFR2b binds to FGF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11793", "l": "H(+) + NADH + O2 + propene => 1,2-epoxypropane + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39950", "l": "1,3-diacyl-sn-glycerol + H2O <=> a fatty acid + a monoacylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050380", "l": "undecaprenyl-diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44369", "l": "Cr(6+) + 2 NADPH + O2 => Cr(3+) + 2 H(+) + 2 NADP(+) + superoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10799", "l": "albendazole + H(+) + NADPH + O2 <=> albendazole S-oxide + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15515", "l": "ADP + H(+) + keto-D-tagatose 6-phosphate => ATP + keto-D-tagatose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.181", "l": "\"Galactan endo-beta-1,3-galactanase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783530", "l": "gp130:JAKs bind CNTFR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810234", "l": "General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35145", "l": "2,4,6-trihydroxybenzophenone + 3 CO2 + 4 CoA => benzoyl-CoA + 2 H(+) + 3 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606883", "l": "CD19 is phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63886", "l": "H2O + L-dopa => H2O2 + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49761", "l": "EDTA + FMNH2 + O2 => ethylenediaminetriacetate + FMN + glyoxylate + 2 H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371537", "l": "DBC1 binds SIRT1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60798", "l": "3 CO2 + gibberellin A20 + 2 H2O + 2 succinate => 2 2-oxoglutarate + gibberellin A53 + H(+) + 3 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24994", "l": "2 H(+) + H2O + N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase] => L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.16", "l": "\"Methylthioadenosine nucleosidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044716", "l": "8-oxo-GDP phosphatase activity"}, {"i": "RHEA:32063", "l": "8-oxo-dGDP + H2O = 8-oxo-dGMP + H(+) + phosphate"}, {"i": "RHEA:62356", "l": "8-oxo-GDP + H2O = 8-oxo-GMP + H(+) + phosphate"}, {"i": "EC:3.6.1.58", "l": "\"8-oxo-dGDP phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32022", "l": "(2E,6E)-farnesyl diphosphate <=> beta-cubebene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938853", "l": "CDK6 binds RUNX1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140396", "l": "5'-hydroxyaverantin dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62176", "l": "GDP-alpha-D-glucose + H2O = alpha-D-glucose 1-phosphate + GMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10791", "l": "2-dehydro-D-gluconate + ATP <=> 6-phospho-2-dehydro-D-gluconate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869580", "l": "DEK binds TFAP2A homodimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220967", "l": "p-NICD1 PEST domain mutants do not bind FBXW7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56473", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 => (5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28275", "l": "(S)-S-adenosyl-L-methionine => (R)-S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64072", "l": "acetyl-CoA + 8 H(+) + holo-[ACP] + 8 malonyl-CoA = 3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 8 CO2 + 9 CoA + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13302", "l": "a 1,2-diacyl-sn-glycerol + a sterol => a 1-acyl-sn-glycerol + a sterol ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30511", "l": "2-demethylmenaquinone-8 + H(+) + NADPH = 2-demethylmenaquinol-8 + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38012", "l": "chlorophyll a + H2O => chlorophyllide a + H(+) + phytol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.38", "l": "\"Cathepsin K\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22182", "l": "(S)-norcodamine + H(+) + S-adenosyl-L-homocysteine => (S)-norreticuline + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139941", "l": "Binding of IP3 to IP3 receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428749", "l": "Activated TP receptor binds G-proten Gq (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802165", "l": "TP53 binds the PLK3 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018698", "l": "vinyl chloride reductive dehalogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3858482", "l": "DVL is recruited to the receptor (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47389", "l": "a tetradecanoate ester + H2O => an aliphatic alcohol + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36332", "l": "ATP + dimethylallyl diphosphate => diphosphate + N(6)-(dimethylallyl)adenosine 5'-triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944266", "l": "Association of procollagen type XI (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473584", "l": "Collagen type III degradation by MMP15 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35978", "l": "2-oxoglutarate + AH2 + fumitremorgin B + 2 O2 <=> A + CO2 + H2O + succinate + verruculogen"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50684", "l": "H2O + N(5)-phenyl-L-glutamine = aniline + H(+) + L-glutamate"}, {"i": "EC:3.5.1.123", "l": "\"Gamma-glutamylanilide hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28547", "l": "D-glucose => D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38371", "l": "1-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49000", "l": "aurachin C + H(+) + NADH + O2 = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27529", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (2E,6E)-farnesol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56157", "l": "(12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine => (12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016690", "l": "diarylpropane peroxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2545196", "l": "FN1 dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52883", "l": "16beta,17beta-estriol + UDP-alpha-D-glucuronate <=> 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2545253", "l": "Deacetylation of cohesin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63497", "l": "4-nitrobenzaldehyde + H(+) + NADPH => 4-nitrobenzyl alcohol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30971", "l": "7,7',9,9'-tetra-cis-lycopene = all-trans-lycopene"}, {"i": "EC:5.2.1.13", "l": "\"Prolycopene isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202328", "l": "Translocation of PKC theta to plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032090", "l": "Pyrin domain binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016490", "l": "structural constituent of peritrophic membrane"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46337", "l": "3-oxochola-4,17-dien-22-oyl-CoA + H2O => 17-hydroxy-3-oxochol-4-en-22-oyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59061", "l": "(20S)-ginsenoside Rg3 + H2O => (20S)-ginsenoside Rh2 + D-glucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033190", "l": "solanapyrone synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27960", "l": "cytosine + D-ribose => cytidine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866941", "l": "MID1IP1 binds THRSP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013159", "l": "CDC42 GEFs activate CDC42 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018807", "l": "RAC3 GDIs block activation of RAC3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13086", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O => CoA + L-2-acetamido-6-oxoheptanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54362", "l": "3-methylbutanal + CO2 => 4-methyl-2-oxopentanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000254", "l": "C-4 methylsterol oxidase activity"}, {"i": "REACT:R-HSA-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33494", "l": "2-hydroxyhexacosanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxyhexacosanoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000297", "l": "spermine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19754", "l": "ATP + diphthine-[translation elongation factor 2] + NH4(+) => AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18571", "l": "an aromatic carboxylate + H(+) + H2O2 => an aromatic aldehyde + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008735", "l": "carnitine dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64925", "l": "dATP + 2 H2O => dAMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54742", "l": "19-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76052", "l": "Binding of TFIIIA To type 1 Promoter (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0043022", "l": "ribosome binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55107", "l": "3-oxoheptanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyheptanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17773", "l": "ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)"}, {"i": "EC:6.1.1.16", "l": "\"Cysteine--tRNA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46007", "l": "2-methylpropanal + CoA + NAD(+) <=> 2-methylpropanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15878", "l": "2-oxoglutarate + pyridoxamine 5'-phosphate => D-glutamate + pyridoxal 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26462", "l": "6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine = 3-methyl-6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700175", "l": "Active ALK phosphorylates SHC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0160002", "l": "ADP-D-ribose modification-dependent protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607753", "l": "CARD9 oligomerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23333", "l": "(2R)-3-phosphoglycerate + GTP => (2R)-3-phospho-glyceroyl phosphate + GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19624", "l": "a nucleoside 2',3'-cyclic phosphate + H2O <=> a nucleoside 3'-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45971", "l": "androst-4-ene-3,17-dione + H(+) + NADH + O2 <=> 9alpha-hydroxy-androst-4-ene-3,17-dione + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35897", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41545", "l": "8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine => 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23478", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O => 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029451", "l": "Activation of RAC1 by VAV (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2314678", "l": "Aspirin acetylates PTGS1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0008066", "l": "glutamate receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28342", "l": "dITP + H2O = dIMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0000099", "l": "sulfur amino acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868071", "l": "Clathrin recruits PIK3C2A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380586", "l": "loading of Serotonin in synaptic vesicles (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046593", "l": "mandelonitrile lyase activity"}, {"i": "RHEA:18313", "l": "(R)-mandelonitrile = benzaldehyde + hydrogen cyanide"}, {"i": "EC:4.1.2.10", "l": "\"(R)-mandelonitrile lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66640", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + koraiol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102141", "l": "[chondroitin sulfate]-D-glucuronyl 2-O-sulfotransferase activity"}, {"i": "MetaCyc:RXN-11560"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875183", "l": "CBL monoubiquitinates activated MET (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65339", "l": "chrodrimanin T + H(+) + NADPH + O2 <=> chrodrimanin A + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58203", "l": "2-oxoglutarate + 6-aminohexanoate <=> 6-oxohexanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.2.1.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10274", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+) => a 1,2-diacyl-sn-glycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418874", "l": "Recruitment and activation of N-WASP by Cdc42 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5660662", "l": "ASC binds Caspase-8 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61898", "l": "betaenone A => betaenone C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362522", "l": "ALDHs oxidise atRAL to atRA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5607734", "l": "PKC-delta translocates to plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047179", "l": "platelet-activating factor acetyltransferase activity"}, {"i": "RHEA:11048", "l": "1-organyl-2-lyso-sn-glycero-3-phospholipid + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-O-alkyl-sn-glycero-3-phosphocholine + 1-organyl-2-acetyl-sn-glycero-3-phospholipid"}, {"i": "EC:2.3.1.149", "l": "\"Platelet-activating factor acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43868", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(in) = a 1-acyl-sn-glycero-3-phosphoethanolamine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26324", "l": "resorcinol + S-adenosyl-L-methionine <=> 3-methoxyphenol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209536", "l": "IkB is ubiquitinated and degraded (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706344", "l": "FLT3 phosphorylates GRB10 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034548", "l": "N-cyclopropylammeline deaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9690461", "l": "FKBP1A binds tacrolimus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52359", "l": "3'-phosphoadenylyl sulfate + pregnenolone <=> adenosine 3',5'-bisphosphate + H(+) + pregnenolone sulfate"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0097243", "l": "flavonoid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29969", "l": "2'-deoxyuridine(out) + H(+)(out) => 2'-deoxyuridine(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419428", "l": "S1PR2-5 bind S1P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17989", "l": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47688", "l": "cis-4-hydroxy-L-proline + NADP(+) = Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112121", "l": "Oxidative dealkylation of 1-etA damaged DNA By ALKBH2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30339", "l": "H(+) + L-tryptophan = CO2 + tryptamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696274", "l": "RND1 binds GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159796", "l": "Furin cleaves pro-factor IX to factor IX (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452894", "l": "Expression of SOX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.23", "l": "\"Sugar-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49199", "l": "2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol <=> 25-hydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42063", "l": "11-cis-retinol + NAD(+) <=> 11-cis-retinal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5679266", "l": "Beclin-1 complex translocates to the ER (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15586", "l": "15-cis-phytoene + 4 A => 4 AH2 + all-trans-lycopene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070052", "l": "collagen V binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2176445", "l": "SMURF2 binds SMAD2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50981", "l": "prostaglandin E1(out) => prostaglandin E1(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32444", "l": "all-trans-zeaxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45326", "l": "H(+) + N-tetracosanoyl-sphing-4-enine + phosphocholine => H2O + N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710354", "l": "GSDME (1-270) binds cardiolipin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50121", "l": "taurine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-taurine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047960", "l": "glycine dehydrogenase activity"}, {"i": "MetaCyc:GLYCINE-DEHYDROGENASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709360", "l": "H2O2 reduces MetHb (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45872", "l": "15-hydroxypentadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(14-hydroxytetradecyl)-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60966", "l": "(9Z)-17-hydroxyoctadec-9-enoate 17-O-sophoroside + H(+) + UDP => (9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980109", "l": "Cleavage of CNTN1:NOTCH1 complex releases NICD1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13866", "l": "GDP-alpha-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol => beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102119", "l": "gibberellin A20 carboxyl methyltransferase activity"}, {"i": "MetaCyc:RXN-11360"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.-.-", "l": "\"Other lyases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668831", "l": "CST complex formation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009072", "l": "STAT3 phosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42253", "l": "H(+) + malonyl-[ACP] + pentanoyl-CoA => 3-oxoheptanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638004", "l": "RP2 binds ARL3:GTP:UNC119B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14098", "l": "3-phenylpyruvate + L-aspartate => L-phenylalanine + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22803", "l": "cycloeucalenol <=> obtusifoliol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679780", "l": "SIGMAR1 binds fluvoxamine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13772", "l": "glycerol + NAD(+) <=> dihydroxyacetone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24434", "l": "acetate + H(+) + oxalate => H2O + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11013", "l": "H2O + L-tryptophanamide => L-tryptophan + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814831", "l": "TBC1D20 binds RAB1:GTP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000155", "l": "phosphorelay sensor kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53376", "l": "5,6-dihydrouridine(16) in tRNA + NADP(+) = H(+) + NADPH + uridine(16) in tRNA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050695", "l": "benzoylformate decarboxylase activity"}, {"i": "RHEA:23368", "l": "H(+) + phenylglyoxylate = benzaldehyde + CO2"}, {"i": "EC:4.1.1.7", "l": "\"Benzoylformate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10620", "l": "(E)-cinnamaldehyde + CoA + NADP(+) = (E)-cinnamoyl-CoA + H(+) + NADPH"}, {"i": "EC:1.2.1.44", "l": "\"Cinnamoyl-CoA reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20725", "l": "a 4-saturated-(3S)-3-hydroxyacyl-CoA => a (3E)-enoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64401", "l": "an L-amino acid tripeptide(out) + H(+)(out) => an L-amino acid tripeptide(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9032798", "l": "DOCK3 activates RAC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34464", "l": "8-hydroxycopalyl diphosphate => cis-abienol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39300", "l": "(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.50"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2429719", "l": "MCPH1 sequesters condensin II (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877153", "l": "STARD7 binds PC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16192", "l": "3-(4-hydroxyphenyl)pyruvate + O2 <=> CO2 + homogentisate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13001", "l": "1D-myo-inositol hexakisphosphate + H2O = 1L-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate"}, {"i": "EC:3.1.3.72", "l": "\"5-phytase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37755", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19276", "l": "H2O + N-acetyl-D-mannosamine + phosphoenolpyruvate <=> N-acetylneuraminate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38330", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27303", "l": "7-chloro-L-tryptophan + O2 => 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047993", "l": "hydroxymalonate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59155", "l": "ATP + CoA + pseudomonate C <=> AMP + diphosphate + pseudomonoyl-CoA C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42167", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2 <=> (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45072", "l": "(9Z)-octadecenoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] = (9Z)-18-hydroxyoctadecenoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "RHEA:45076", "l": "(9Z,12Z)-octadecadienoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] = (9Z,12Z)-18-hydroxyoctadecadienoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.129", "l": "\"Long-chain acyl-CoA omega-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008819", "l": "cobinamide kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33451", "l": "A + H2O + N(6),N(6)-dimethyl-L-lysyl-[protein] = AH2 + formaldehyde + N(6)-methyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9734730", "l": "ORC1 translocates to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29723", "l": "glyoxylate(in) = glyoxylate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57449", "l": "ATP + D-tyrosine + tRNA(Tyr) => AMP + D-tyrosyl-tRNA(Tyr) + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57036", "l": "[(1->6)-alpha-D-glucosyl](n) + sucrose = (1->3)-alpha-D-glucosyl-[(1->6)-alpha-D-glucosyl]n + D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672973", "l": "MAP2Ks phosphorylate MAPKs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21640", "l": "NADP(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH"}, {"i": "EC:1.3.1.13", "l": "\"Prephenate dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32606", "l": "(6E)-8-hydroxygeraniol + NADP(+) <=> (6E)-8-oxogeraniol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18612", "l": "carbamoyl phosphate + N(2)-acetyl-L-ornithine <=> H(+) + N(2)-acetyl-L-citrulline + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036191", "l": "indolin-2-one monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9639286", "l": "RRAGC,D exchanges GTP for GDP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36363", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 H(+) + 2 NADPH = (9Z,12Z)-octadecadien-1-ol + CoA + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62941", "l": "H2O + N(4)-acetylcytosine => acetate + cytosine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050317", "l": "tagatose kinase activity"}, {"i": "MetaCyc:TAGATOSE-KINASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28642", "l": "(2Z,6E)-farnesyl diphosphate <=> (-)-gamma-cadinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22718", "l": "(24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098622", "l": "selenodiglutathione-disulfide reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63744", "l": "UDP-alpha-D-glucuronate + zolasartan = UDP + zolarsartan-1-N-beta-D-glucuronide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5666001", "l": "Profilin:G-actin binds MKL1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60736", "l": "(2E,6E)-farnesal + H2O + NADP(+) = (2E,6E)-farnesoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59876", "l": "(indol-3-yl)butanoate + ATP + L-cysteine = (indol-3-yl)butanoyl-L-cysteine + AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30022", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A <=> ADP + H(+) + lipid A-core"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8954056", "l": "E2F6 binds TFDP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809680", "l": "MTMR12 binds MTM1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60064", "l": "a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2 = a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28134", "l": "(2S)-hesperidin + H2O = (2S)-hesperetin + rutinose"}, {"i": "EC:3.2.1.168", "l": "\"Hesperidin 6-O-alpha-L-rhamnosyl-beta-D-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045483", "l": "aristolochene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454916", "l": "The ABCC family mediates organic anion transport (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22137", "l": "7(1)-hydroxychlorophyllide a + H(+) + NADPH + O2 => chlorophyllide b + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52992", "l": "[deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + [eIF5A protein]-L-lysine = [deoxyhypusine synthase]-L-lysine + [eIF5A protein]-N-(4-aminobutylidene)-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63763", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine <=> 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.119", "l": "\"Kallikrein 13\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3240957", "l": "Formation of PRC2-EZH2 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199154", "l": "CD200 binds to CD200R (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20209", "l": "ATP + xylitol = ADP + H(+) + xylitol 5-phosphate"}, {"i": "EC:2.7.1.122", "l": "\"Xylitol kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63971", "l": "2 3-(4-hydroxyphenyl)pyruvate + H(+) <=> atromentin + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10238", "l": "H(+) + trans-beta-D-glucosyl-2-hydroxycinnamate + UDP => trans-2-coumarate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32906", "l": "calciol + O2 + reduced [NADPH--hemoprotein reductase] <=> calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031722", "l": "hemoglobin beta binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40870", "l": "(9E)-octadecenoyl-CoA + FAD + H(+) <=> (2E,9E)-octadecadienoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797100", "l": "CCNK binds CDK13 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17823", "l": "3-cyano-L-alanine + H(+) + hydrogen sulfide => hydrogen cyanide + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46103", "l": "11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> cortisol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111879", "l": "PIP2 hydrolysis (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60771", "l": "3 2-oxoglutarate + gibberellin A12 + 3 O2 <=> 3 CO2 + gibberellin A25 + H(+) + H2O + 3 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-167415", "l": "G-protein alpha subunit is inactivated (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18031", "l": "2 ADP + carbamoyl phosphate + 2 H(+) + phosphate => 2 ATP + hydrogencarbonate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-947514", "l": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043533", "l": "inositol 1,3,4,5 tetrakisphosphate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29617", "l": "alpha-maltotetraose + beta-D-glucose => alpha-maltotriose + beta-maltose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16431", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.1", "l": "\"Cathepsin B\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36275", "l": "H(+) + NADPH + O2 + theophylline = 3-methylxanthine + formaldehyde + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11930", "l": "H(+) + H2O + hydrazine => hydroxylamine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33377", "l": "a 1-acyl-sn-glycero-3-phosphate + NADP(+) => a 1-acylglycerone 3-phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63894", "l": "AMP + D-tryptophan + diphosphate + H(+) => ATP + H2O + L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31659", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GlcpNAc + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879762", "l": "Expression of DBP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44421", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O => a 1-acyl-sn-glycero-3-phosphate + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2172666", "l": "RB1 binds condensin II (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.94", "l": "\"Proprotein convertase 2\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52958", "l": "hyodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP => hyodeoxycholate + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793122", "l": "MRM1 methylates guanosine-1145 of 16S rRNA yielding 2'-O-methylguanosine-1145 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17157", "l": "ATP + creatine = ADP + H(+) + N-phosphocreatine"}, {"i": "EC:2.7.3.2", "l": "\"Creatine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381607", "l": "Activated Adenylyl cyclase synthesizes cyclic AMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41898", "l": "NADP(+) + tetradecanoyl-[ACP] => (2E)-tetradecenoyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17211", "l": "2-formylglutarate + NH4(+) => 1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19870", "l": "an acyl-CoA + glycine => an N-acylglycine + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626227", "l": "CP110 and CEP97 dissociate from the centriole (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981610", "l": "Neuroglobin binds oxygen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56973", "l": "(R)-3-hydroxy-2-methylpropanoate + NAD(+) => (R)-methylmalonate semialdehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806613", "l": "Keratin tetramers bind to form unit length filaments (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-593685", "l": "Netrin-4 binds DCC/UNC5A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "75.324974028080362", "identifiers": [{"i": "GO:0016833", "l": "oxo-acid-lyase activity"}, {"i": "EC:4.1.3.-", "l": "\"Oxo-acid-lyases\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047089", "l": "dihydrochelirubine 12-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5334827", "l": "SUMO-CRABP2 binds atRA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086132", "l": "Dentin phosphoprotein binds integrin alphaVbeta1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53198", "l": "16alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690494", "l": "RHOB translocates to the endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66120", "l": "2-oxobutanoate + L-methionine = (2S)-2-aminobutanoate + 4-methylsulfanyl-2-oxobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649856", "l": "Oxidative damage to the AP site (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034029", "l": "2-oxoglutarate carboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685156", "l": "ATR phosphorylates RPA2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2129357", "l": "Fibrillin C-terminal processing (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62422", "l": "a fatty acid + CO2 + H2O => a (R)-2-hydroxy fatty acid + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2514865", "l": "cGMP dissociates from CNG channels (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034953", "l": "perillyl-CoA hydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564120", "l": "Collagen type VII degradation by MMP1,2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20823", "l": "choline sulfate + H2O <=> choline + H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57012", "l": "a menaquinone + H2O + sulfite = a menaquinol + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222341", "l": "H2O2 gets scavenged by unsaturated lipid (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10665", "l": "NAD(+) + perillyl alcohol => H(+) + NADH + perillyl aldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53497", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O => a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18651", "l": "2-dehydro-3-deoxy-D-galactonate + H2O => D-galactonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31928", "l": "3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49488", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate = 2-oxoglutarate + GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)"}, {"i": "EC:4.2.1.168", "l": "\"GDP-4-dehydro-6-deoxy-alpha-D-mannose 3-dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20915", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + taxa-4,11-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42375", "l": "16-methoxytabersonine + H2O <=> (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437139", "l": "ZnT6 transports zinc into the golgi apparatus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59883", "l": "4-hydroxyphenylacetate + FMNH2 + O2 <=> 3,4-dihydroxyphenylacetate + FMN + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47613", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983194", "l": "Kinesin-1 is a heterotetramer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784959", "l": "BPHL hydrolyses VACV to ACV (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034827", "l": "1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008399", "l": "naphthalene hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52813", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O => (9Z,12Z)-octadecadienoate + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32403", "l": "(1R,2S,4R)-neodihydrocarveol + NAD(+) = (1R,4R)-dihydrocarvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659734", "l": "Defective SLC6A19 does not cotransport neutral amino acids, Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061655", "l": "Pup conjugating enzyme activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444661", "l": "HCAR2 binds HCAR2 ligands (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32432", "l": "(1R,4S)-menthone + H(+) + NADPH + O2 => (4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60578", "l": "[Co(I) tetramethylammonium-specific corrinoid protein] + H(+) + methyl-coenzyme M => [methyl-Co(III) tetramethylammonium-specific corrinoid protein] + coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.-", "l": "\"With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3149492", "l": "cob(II)alamin dissociates from MMACHC:MMADHC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33840", "l": "(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin + H(+) => 7-O-geranyl-2-O,3-dimethylflaviolin + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811431", "l": "RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987039", "l": "JAK1 binds IL20RA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602473", "l": "Autocatalytic activation of MMP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-990489", "l": "Kinesin-13 is a dimer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.99.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417890", "l": "P2Y5 receptor can bind to LPA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22230", "l": "diphosphate + NAD(+) + squalene => H(+) + NADH + presqualene diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17369", "l": "glycyrrhizin + H2O = 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate"}, {"i": "EC:3.2.1.128", "l": "\"Glycyrrhizinate beta-glucuronidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19129", "l": "ATP + thymidine = ADP + dTMP + H(+)"}, {"i": "EC:2.7.1.21", "l": "\"Thymidine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52372", "l": "17beta-estradiol + 3'-phosphoadenylyl sulfate = 17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52399", "l": "4-O-phospho-D-threonate + NAD(+) <=> CO2 + dihydroxyacetone phosphate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48571", "l": "3-chlorocatechol + O2 <=> (2E,4Z)-2-chloromuconate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54288", "l": "ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381337", "l": "Expression of CEBPB in adipogenesis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102319", "l": "2-deoxystreptamine N-acetyl-D-glucosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24925", "l": "2-oxobutanoate + NH4(+) => L-homoserine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17732", "l": "an acyl-CoA + cholesterol <=> a cholesterol ester + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20483", "l": "adenosine 3',5'-bisphosphate + H(+) + luciferyl sulfate => 3'-phosphoadenylyl sulfate + coelenterazine h"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34655", "l": "C30 botryococcene + 2 S-adenosyl-L-methionine = 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 H(+) + 2 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.263", "l": "\"Botryococcene C-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22215", "l": "(2R,3R)-tartrate <=> (2R,3S)-tartrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37996", "l": "all-trans-nonaprenyl diphosphate + H(+) + homogentisate => 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11674", "l": "4-amino-4-deoxychorismate + L-glutamate => chorismate + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450474", "l": "MK2 phosphorylates BRF1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27941", "l": "(3R)-3-hydroxy-D-aspartate <=> glycine + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-445714", "l": "Aquaporin-3 passively transports water out of cell (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66215", "l": "asc-omegaC5-CoA + O2 <=> asc-omegaDeltaC5-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592229", "l": "TFAM translocates from the cytosol to the mitochondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114354", "l": "SMAC binds XIAP:Caspase-7 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58864", "l": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 = 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627078", "l": "XIAP binds CASP9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111879", "l": "PIP2 hydrolysis (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36420", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37810", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391152", "l": "p-4Y-SIRPA:CD47 binds PTK2B (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1297444", "l": "Binding of cAMP to HCN channels (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186778", "l": "SHP2 binds to the active receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617855", "l": "HOXC4 mRNA is translated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37878", "l": "aklanonate + S-adenosyl-L-methionine <=> methyl aklanonate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202969", "l": "Caspase mediated cleavage of beta-catenin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50917", "l": "a carboxylate + ATP + H(+) + NADPH => AMP + an aldehyde + diphosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49772", "l": "glycine + hexacosanoyl-CoA = CoA + H(+) + N-hexacosanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41466", "l": "ent-sandaracopimaradien-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-sandaracopimara-8(14),15-diene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38510", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42499", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate <=> 10-deacetyl-2-debenzoylbaccatin III"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9611852", "l": "ADRB3 bind ADR,NAd (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-453339", "l": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52264", "l": "3-(aminomethyl)indole + 2 S-adenosyl-L-methionine = gramine + 2 H(+) + 2 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.340", "l": "\"3-aminomethylindole N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034816", "l": "anthracene 9,10-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166869", "l": "TRAF6 binds MEKK1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693250", "l": "RHOD binds effectors at the Golgi membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12253", "l": "4-O-(beta-D-glucosyl)-trans-coniferol + H2O => (E)-coniferol + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60129", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O => 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56623", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + H2O <=> 2,4,5-trichlorocyclohexa-2,5-dien-1-ol + chloride + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40923", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951926", "l": "RUNX1 gene expression is inhibited by RUNX3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46030", "l": "(2R)-hydroxytetradecanoate + H2O => H2O2 + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65326", "l": "chrodrimanin B + CoA => acetyl-CoA + chrodrimanin A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424482", "l": "p85 regulatory unit of PI3K binds p-6Y-SYK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20861", "l": "(1S,6R)-isopiperitenol + NAD(+) => (6R)-isopiperitenone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103086", "l": "methylthiopentylmalate isomerase activity"}, {"i": "MetaCyc:RXNQT-4170"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34223", "l": "6-hydroxypseudooxynicotine + A + H2O = 2,6-dihydroxypseudooxynicotine + AH2"}, {"i": "EC:1.5.99.14", "l": "\"6-hydroxypseudooxynicotine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047552", "l": "2-oxoaldehyde dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804266", "l": "CHEK2 phosphorylates TTC5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56033", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21822", "l": "H(+) + L-methionine + S-adenosyl-L-homocysteine => L-homocysteine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019177", "l": "dihydroneopterin triphosphate pyrophosphohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34775", "l": "a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) = a 3-oxosteroid + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55776", "l": "all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate = 4-hydroxy-4-O-(beta-D-glucuronide)-all-trans-retinoate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47888", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2301205", "l": "SETD8 monomethylates histone H4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2197690", "l": "Detachment of WASP/WAVE (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-435244", "l": "PECAM1 is phosphorylated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27608", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9016861", "l": "PTCRA gene expression is stimulated by NOTCH3 and inhibited by IK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865276", "l": "PDGF-AB clevage by Furin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1470010", "l": "Dimerization of STATs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34931", "l": "glutathioselenol + NADPH = glutathione + hydrogenselenide + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1299338", "l": "Activation of TRESK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31571", "l": "1-hydroxy-2-naphthoate + 2 H(+) + NADPH + O2 = CO2 + H2O + NADP(+) + naphthalene-1,2-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866321", "l": "VLDL binds APOC1 and APOC4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19650", "l": "ATP + L-aspartate + tRNA(Asp) => AMP + diphosphate + L-aspartyl-tRNA(Asp)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47063", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662114", "l": "ATP2B2-wa (PMCA2-wa) transports Ca2+ from the cytosol to the extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43650", "l": "3-oxooctadecanoyl-[ACP] + CO2 + CoA => H(+) + hexadecanoyl-CoA + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.27"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61526", "l": "(15S)-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112396", "l": "Separation of elongating transcript from template (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905334", "l": "Swi5-Sfr1 complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55801", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + N-acyleicosasphinganine + O2 => 2 [Fe(III)-cytochrome b5] + 2 H2O + N-acyleicosasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944266", "l": "Association of procollagen type XI (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-420975", "l": "Ca impermeable AMPA receptor ligand binding (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31002", "l": "(S)-2,3-epoxysqualene <=> cucurbitadienol"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0003956", "l": "NAD(P)+-protein-arginine ADP-ribosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380198", "l": "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5686430", "l": "MUS81 binds EME1, EME2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865276", "l": "PDGF-AB clevage by Furin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3296244", "l": "SUCNR1 binds SUCCA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674531", "l": "AAMP binds EGFR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32714", "l": "a (3R)-3-hydroxyacyl-CoA + NAD(+) <=> a 3-oxoacyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047703", "l": "beta-nitroacrylate reductase activity"}, {"i": "RHEA:23892", "l": "3-nitropropanoate + NADP(+) = 3-nitroacrylate + H(+) + NADPH"}, {"i": "EC:1.3.1.16", "l": "\"Beta-nitroacrylate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44317", "l": "1-dodecanoylglycerol + H2O => dodecanoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030229", "l": "very-low-density lipoprotein particle receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710254", "l": "GSDME oligomerizes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0043783", "l": "oxidoreductase activity, acting on metal ions, flavin as acceptor"}, {"i": "EC:1.16.8.-", "l": "\"With a flavin as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54256", "l": "2-oxoglutarate + L-histidyl-[protein] + O2 = (3S)-3-hydroxy-L-histidyl-[protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2214351", "l": "PLK1 phosphorylates GORASP1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18503", "l": "ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) + NADPH => ergosterol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26412", "l": "(R)-lactate + N-acetyl-D-glucosamine 6-phosphate => H2O + N-acetyl-D-muramate 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25665", "l": "(2E)-geranyl diphosphate <=> alpha-pinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0009678", "l": "pyrophosphate hydrolysis-driven proton transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-622310", "l": "Activated NOD1 oligomerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34132", "l": "neryl diphosphate + olivetolate => cannabinerolate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.3.2.3", "l": "\"ABC-type sulfate transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606807", "l": "Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47835", "l": "ganglioside GD1a + H2O <=> ganglioside GM1 + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046932", "l": "sodium-transporting ATP synthase activity, rotational mechanism"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043431", "l": "2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase activity"}, {"i": "MetaCyc:2.1.1.64-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32168", "l": "ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine => aerobactin + AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59108", "l": "chenodeoxycholate + octyl beta-D-glucose = beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5625426", "l": "Retrograde IFT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870461", "l": "RABGGTA and RABGGTB bind (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65977", "l": "cholesta-5,7-dien-3beta-ol + hnu => previtamin D3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16979", "l": "2-oxopropyl-coenzyme M + CO2 + NADPH => acetoacetate + coenzyme M + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22561", "l": "(3R)-vestitone + NADP(+) => 2'-hydroxyformononetin + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090486", "l": "small RNA 2'-O-methyltransferase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57884", "l": "diphosphate + H2O + Na(+)(in) = H(+) + Na(+)(out) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080107", "l": "8-methylthiopropyl glucosinolate S-oxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49168", "l": "8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine = 8,12-diethyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.331", "l": "\"Bacteriochlorophyllide d C-12(1)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418172", "l": "F2R binds ARRB2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56167", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3-phosphocholine <=> (9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-164832", "l": "ATPase synthesizes ATP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204485", "l": "Basigin binds CyPA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004099", "l": "chitin deacetylase activity"}, {"i": "RHEA:10464", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = n acetate + chitosan"}, {"i": "EC:3.5.1.41", "l": "\"Chitin deacetylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700149", "l": "Active ALK binds PLCG1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380782", "l": "STAT binds to the active receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27668", "l": "CO2 + propanoyl-CoA => (R)-methylmalonyl-CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61731", "l": "a 3-dehydro-D-guloside <=> a 3-dehydro-D-glucoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26254", "l": "H(+) + isopimara-7,15-dienol + NADPH + O2 => 2 H2O + isopimara-7,15-dienal + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034010", "l": "sulfolactate sulfo-lyase activity"}, {"i": "RHEA:21428", "l": "(R)-3-sulfolactate = H(+) + pyruvate + sulfite"}, {"i": "EC:4.4.1.24", "l": "\"(2R)-sulfolactate sulfo-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61380", "l": "2,4-dinitrophenyl-S-glutathione(in) + ATP + H2O = 2,4-dinitrophenyl-S-glutathione(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32966", "l": "2-oxoglutaramate + H2O <=> 2-oxoglutarate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32081", "l": "(13E)-labda-7,13-dien-15-ol + diphosphate => (13E)-labda-7,13-dien-15-yl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708466", "l": "BACH1 translocates from the nucleoplasm to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36056", "l": "a 2-amino-4-hydroxypteridine + H(+) + H2O => a 2,4-dihydroxypteridine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23822", "l": "GDP-4-dehydro-alpha-D-rhamnose + H2O => GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29422", "l": "H(+)(out) + Na(+)(in) <=> H(+)(in) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033833", "l": "hydroxymethylfurfural reductase (NADH) activity"}, {"i": "MetaCyc:RXN-10738"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39620", "l": "(2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H(+) + NADPH => (14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64978", "l": "8-oxo-dGMP + 2 H(+) + 2 phosphate => 8-oxo-dGTP + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12766", "l": "CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate => acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23409", "l": "NADP(+) + precorrin-6B => 2 H(+) + NADPH + precorrin-6A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938121", "l": "SERPINB13 binds CTSK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373342", "l": "CX3CR1 binds CX3CL1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45987", "l": "3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH + O2 <=> 9alpha-hydroxy-3-oxochola-1,4-dien-22-oyl-CoA + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47546", "l": "cis-4-hydroxy-D-proline betaine => trans-4-hydroxy-L-proline betaine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694462", "l": "ABHD6,12 hydrolyse 3AG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40051", "l": "chorismate = 3-[(1-carboxyvinyl)-oxy]benzoate + H2O"}, {"i": "EC:4.2.1.151", "l": "\"Chorismate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50403", "l": "L-cysteinyl-[PqsC protein] + octanoyl-CoA <=> CoA + S-octanoyl-L-cysteinyl-[PqsC protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686015", "l": "Nsp3, nsp4, and nsp6 produce replicative organelles (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-159194", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1028820", "l": "Formation of VAF (virus-activated factor) complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52418", "l": "CO2 + dihydroxyacetone phosphate => 3-dehydro-4-O-phospho-D-erythronate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166542", "l": "beta-NGF dimer binds to TrkA receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015349", "l": "thyroid hormone transmembrane transporter activity"}, {"i": "REACT:R-HSA-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Homo sapiens)"}, {"i": "REACT:R-HSA-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708292", "l": "DICER1 cleaves tRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62842", "l": "GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54875", "l": "(1S,4R)-menthone + H(+) + NADPH + O2 <=> (4S,7R)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798347", "l": "E2F7 and E2F8 homo- and heterodimers bind the E2F1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62686", "l": "H(+) + rubrofusarin + S-adenosyl-L-homocysteine => norrubrofusarin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42487", "l": "D-sorbitol(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-sorbitol 6-phosphate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17866", "l": "5,6,7,8-tetrahydropteridine + NADP(+) => 6,7-dihydropteridine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46063", "l": "(11E)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (5Z,11E)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40477", "l": "butanoate + dibutanoylglycerol + H(+) => 1,2,3-tributanoylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227881", "l": "Phosphorylation and release of IRF3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16618", "l": "beta-D-glucosyl-(1->3)-D-glucose + phosphate => alpha-D-glucose 1-phosphate + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186786", "l": "Autophosphorylation of PDGF beta receptors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64754", "l": "3-sulfanyl-1-pentanol + NH4(+) + pyruvate => 3-sulfanylpentan-1-ol-L-cysteine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807872", "l": "Active ARF recruits coatomer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097005", "l": "adipokinetic hormone receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956568", "l": "RUNX1 binds the core TAL1 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052899", "l": "N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity"}, {"i": "MetaCyc:RXN-10460"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59969", "l": "L-threonyl-[protein] + octanoyl-CoA => CoA + O-octanoyl-L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659989", "l": "Defective TALDO1 does not transform SH7P, GA3P to Fru(6)P, E4P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390641", "l": "ADRA1A,B,D bind ADR,NAd (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2288097", "l": "Condensin II complex binds H4K20me1-containing nucleosomes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63774", "l": "1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16304", "l": "H2O + NAD(+) <=> ADP-D-ribose + H(+) + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59654", "l": "D-xylotetraonate + H(+) => D-xylotetraono-1,5-lactone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45253", "l": "tetradecanoate(out) => tetradecanoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130731", "l": "Formation of COPII vesicle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862700", "l": "CMKLR1 binds Resolvin E1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42048", "l": "3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47981", "l": "dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose => dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12003", "l": "formate + NADP(+) <=> CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645535", "l": "ALPK1 phosphorylates TIFA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1462005", "l": "pro-defensin alpha 5 is secreted (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749197", "l": "ORC1 binds to H4K20me2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63495", "l": "H(+) + menadione + NADPH <=> menadiol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39736", "l": "3-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 3,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23567", "l": "2 columbamine + O2 <=> 2 berberine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57631", "l": "3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate <=> H2O + ML-236C carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004873", "l": "asialoglycoprotein receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416516", "l": "GRK2 sequesters activated Gq (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004063", "l": "aryldialkylphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27839", "l": "9H-carbazole + H(+) + NADH + O2 => 2'-aminobiphenyl-2,3-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52591", "l": "choloyl-CoA + NAD(+) <=> 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63534", "l": "angiotensin-(1-9) + L-leucine => angiotensin I + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28138", "l": "H2O + streptothricin F = streptothricin F acid"}, {"i": "RHEA:28142", "l": "H2O + streptothricin D = streptothricin D acid"}, {"i": "EC:3.5.2.19", "l": "\"Streptothricin hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54235", "l": "1,2-dioctanoyl-sn-glycerol + CDP-choline <=> 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17777", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)"}, {"i": "EC:3.1.1.47", "l": "\"1-alkyl-2-acetylglycerophosphocholine esterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39085", "l": "acetyl-CoA + decanedioyl-CoA => 3-oxododecanedioyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682377", "l": "LC3 de-lipidation by ATG4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11239", "l": "putrescine + spermidine <=> propane-1,3-diamine + sym-homospermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197958", "l": "FPGS-2 transforms THF to THFPG (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43747", "l": "ATP + cytidine(34) in tRNA(Ile2) + L-lysine <=> AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264615", "l": "Loading of acetylcholine in synaptic vesicles (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047655", "l": "allyl-alcohol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42646", "l": "diphosphate + holo-[malonate decarboxylase ACP] => 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[malonate decarboxylase ACP]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080012", "l": "trihydroxyferuloyl spermidine O-methyltransferase activity"}, {"i": "MetaCyc:RXN-11263"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62468", "l": "3,4-dihydroxybenzoate + ATP + H(+) = 3,4-dihydroxybenzoyl-5'-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30469", "l": "(+)-endo-beta-bergamotene + diphosphate => (2Z,6Z)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13725", "l": "acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate"}, {"i": "EC:2.3.1.157", "l": "\"Glucosamine-1-phosphate N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0017136", "l": "NAD-dependent histone deacetylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47666", "l": "2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27665", "l": "(S)-2-hydroxyglutarate + O2 <=> 2-oxoglutarate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27330", "l": "H(+) + NADH + O2 + urate => 5-hydroxyisourate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653957", "l": "Rag dimer formation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62574", "l": "glycine + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine => H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteinylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392263", "l": "AVP(20-28) binds AVPR2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11007", "l": "2 H(+) + NADH + O2 + salicylate <=> catechol + CO2 + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34873", "l": "methanol(in) => methanol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37462", "l": "1D-myo-inositol hexakisphosphate + ATP <=> 1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192123", "l": "CYP27A1 27-hydroxylates CHOL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19882", "l": "GTP + L-lysyl-[protein] => diphosphate + H(+) + N(epsilon)-GMP-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9681616", "l": "AP2 binds chlorpromazine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61994", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25020", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57146", "l": "1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44917", "l": "(2E,4E)-decadienoyl-CoA + H(+) + NADPH => (3E)-decenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53457", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z-octadecenoate)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204779", "l": "Interaction of Tie2 with Ang1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018626", "l": "2-chlorobenzoate 1,2-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174494", "l": "Synthesis of ENV polyprotein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-378975", "l": "Follitropin is a heterodimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34525", "l": "[alpha-D-GalNAc-(1->4)]2-[beta-D-Glc-(1->3)]-[alpha-D-GalNAc-(1->4)]2-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + H(+) + UDP => [alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046510", "l": "UDP-sulfoquinovose:DAG sulfoquinovosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103078", "l": "quercetin 3-rhamnoside 7-O-rhamnosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045516", "l": "interleukin-19 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19399", "l": "CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine => (R)-4'-phosphopantothenate + CTP + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168644", "l": "CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60954", "l": "E-sinapate + H(+) + S-adenosyl-L-homocysteine => (E)-5-hydroxyferulate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11400", "l": "GDP-6-deoxy-alpha-D-altrose + sordaricin = 4'-O-demethylsordarin + GDP + H(+)"}, {"i": "EC:2.4.1.353", "l": "\"Sordaricin 6-deoxyaltrosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21590", "l": "H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH => N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354073", "l": "Autophosphorylation of PTK2 at Y397 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61252", "l": "H2O + L-valine + O2 = 3-methyl-2-oxobutanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32077", "l": "(13E)-labda-7,13-dien-15-ol + diphosphate => geranylgeranyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15160", "l": "4-hydroxyphenylacetate + H(+) + NADPH + O2 <=> H2O + homogentisate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182286", "l": "Transport of MHC I:Nef:AP-1:PACS-1 Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65072", "l": "(2E,6E)-farnesyl diphosphate = dauca-4,7-diene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050067", "l": "lysine 2-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66869", "l": "3 O2 + quiannulatene + 3 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + quiannulatate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009018", "l": "sucrose phosphorylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847977", "l": "FRK phosphorylates PTEN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65195", "l": "2 2-oxoglutarate + 2 O2 + preaustinoid A <=> berkeleytrione + 2 CO2 + H2O + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418553", "l": "cAMP degradation by Phosphodiesterases (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050479", "l": "glyceryl-ether monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11272", "l": "a (2R)-2-hydroxycarboxylate + a quinone = a 2-oxocarboxylate + a quinol"}, {"i": "EC:1.1.5.10", "l": "\"D-2-hydroxyacid dehydrogenase (quinone)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647978", "l": "pro-RAS proteins are farnesylated (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68914", "l": "DNA polymerase alpha:primase binds at the origin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420206", "l": "Phosphorylation of SRC-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60924", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2 = CO2 + formaldehyde + L-lysyl-[protein] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106371", "l": "fluorescent chlorophyll catabolite monooxygenase (deformylase) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61329", "l": "O2 + parthenolide + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxyparthenolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23869", "l": "(1-hydroxycyclohexan-1-yl)acetyl-CoA => acetyl-CoA + cyclohexanone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60818", "l": "CO2 + gibberellin A14 + H(+) + succinate => 2-oxoglutarate + gibberellin A14 aldehyde + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043426", "l": "MRF binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57356", "l": "2-oxoglutarate + chloride + H(+) + hapalindole U + O2 = CO2 + H2O + hapalindole G + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.31"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729542", "l": "OTOP1 transports H+ from the extracellular region to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6813626", "l": "LEAP2 binds bacteria (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42541", "l": "uridine(13) in tRNA => pseudouridine(13) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9615348", "l": "AGT(34-41) binds to AGTR2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29928", "l": "(R)-pantothenate(in) + Na(+)(in) => (R)-pantothenate(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28471", "l": "pyridoxine(in) => pyridoxine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866851", "l": "CFTR transits to the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64174", "l": "galactarate => L-altrarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679044", "l": "FKBP1A binds sirolimus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39788", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19291", "l": "phosphate + sucrose => H2O + sucrose 6(F)-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57304", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP = glycolate + GMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65332", "l": "H(+) + NADPH + O2 + verruculide A = chrodrimanin E + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189062", "l": "lactose + H2O => D-glucose + D-galactose (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696482", "l": "CTF1 binds LIFR:JAKs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43309", "l": "1-hexadecanoyl-sn-glycerol + ATP => 1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13871", "l": "3-(4-hydroxyphenyl)pyruvate + CO2 + NADH => NAD(+) + prephenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858491", "l": "WNTs bind the FZD receptor to initiate PCP pathway (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.35", "l": "\"Hyaluronoglucosaminidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37884", "l": "acetyl-CoA + oxalate => acetate + oxalyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29771", "l": "arsenate(in) + ATP + H2O = ADP + arsenate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389523", "l": "BTLA interacts with HVEM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34578", "l": "2 H(+) + O2 + pentalenolactone F + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalenolactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035373", "l": "chondroitin sulfate proteoglycan binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56822", "l": "A + cyclooctat-9-ene-5,7-diol + H2O => AH2 + cyclooctat-9-en-7-ol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19751", "l": "[(1->3)-alpha-D-glucosyl](n+1) + H(+) + UDP => [(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-933533", "l": "Dimerization of p-IRF7 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23813", "l": "(+)-neomenthol + NADP(+) => (1R,4S)-menthone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57202", "l": "N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] => glyoxal + L-arginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610722", "l": "CK1 phosphorylates p-GLI3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45197", "l": "5,6,7,8-tetrahydrosarcinapterin + [methyl-Co(III) corrinoid Fe-S protein] => 5-methyltetrahydrosarcinapterin + [Co(I) corrinoid Fe-S protein] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620828", "l": "FOXO1,FOXO3,(FOXO4) binds CCNG2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42382", "l": "2 AH2 + all-trans-4,4'-diapolycopene-4,4'-dioate + 2 H(+) => 2 A + all-trans-4,4'-diapolycopene-4,4'-dial + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209760", "l": "Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42196", "l": "(9Z)-heptadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-heptadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985343", "l": "RUNX2 binds SOX9 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134883", "l": "Beta-catenin enhances association of IRF3 with CBP/p300  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30728", "l": "dATP + pyruvate => dADP + H(+) + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41580", "l": "5,10-dihydrophenazine 1-carboxylate + dimethylallyl diphosphate = 5,10-dihydro-9-dimethylallylphenazine 1-carboxylate + diphosphate"}, {"i": "EC:2.5.1.121", "l": "\"5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65968", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29549", "l": "2 H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UMP => H2O + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55705", "l": "glycine + hydrogen sulfide + NAD(+) => ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74059", "l": "PDE6 hydrolyses cGMP to GMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043740", "l": "GTP cyclohydrolase IIa activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53992", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21107", "l": "AH2 + cholesterol + O2 <=> 25-hydroxycholesterol + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5227009", "l": "ABCF1 binds EIF2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-383190", "l": "HCO3- transport through ion channel (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3928620", "l": "PAK1 autophosphorylates (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626753", "l": "H2O2 oxidizes Cys residues to form Cys-sulfenic acid (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375151", "l": "Interaction of NCAM1 with collagens (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25792", "l": "ATP + Cu(+)(in) + H2O = ADP + Cu(+)(out) + H(+) + phosphate"}, {"i": "EC:7.2.2.8", "l": "\"P-type Cu(+) transporter\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008973", "l": "phosphopentomutase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874979", "l": "ACBD3 binds GOLGB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.222", "l": "\"Aurachin C monooxygenase/isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050384", "l": "urate-ribonucleotide phosphorylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28958", "l": "D-glucuronate(in) + H(+)(in) <=> D-glucuronate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67149", "l": "L-arginine + L-cysteinyl-[NO transferase protein] + NADPH + 2 O2 => 2 H2O + L-citrulline + NADP(+) + S-nitroso-L-cysteinyl-[NO transferase protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033779", "l": "5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809238", "l": "MTMR7 binds MTMR9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27670", "l": "1D-myo-inositol 1-phosphate + H2O = myo-inositol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48720", "l": "aurachin B + H2O + NAD(+) = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH"}, {"i": "EC:1.1.1.394", "l": "\"Aurachin B dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696947", "l": "USP47 deubiquitinates POLB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63427", "l": "(2S)-2-phospholactate + GTP + H(+) <=> (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42557", "l": "uridine(2819) in 21S rRNA => pseudouridine(2819) in 21S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29605", "l": "4-hydroxybenzoyl-CoA + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => benzoyl-CoA + H2O + oxidized 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.125"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28173", "l": "(2R)-2-hydroxy-2-methylbutanenitrile <=> butan-2-one + hydrogen cyanide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047402", "l": "protein-glucosylgalactosylhydroxylysine glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015546", "l": "sulfathiazole transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36264", "l": "hydroxyurea + O-acetyl-L-serine => acetate + H(+) + O-ureido-L-serine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051009", "l": "O-acetylhomoserine sulfhydrylase activity"}, {"i": "RHEA:10048", "l": "methanethiol + O-acetyl-L-homoserine = acetate + H(+) + L-methionine"}, {"i": "RHEA:27822", "l": "hydrogen sulfide + O-acetyl-L-homoserine = acetate + L-homocysteine"}, {"i": "MetaCyc:ACETYLHOMOSER-CYS-RXN"}, {"i": "EC:2.5.1.49", "l": "\"O-acetylhomoserine aminocarboxypropyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694409", "l": "Nucleotide exchange on RAB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050366", "l": "tyramine N-feruloyltransferase activity"}, {"i": "MetaCyc:TYRAMINE-N-FERULOYLTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788611", "l": "HYKK phosphorylates 5HLYS (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350869", "l": "Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11198", "l": "alpha-ribazole 5'-phosphate + H(+) + nicotinate => 5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350769", "l": "trans-Golgi Network Coat Activation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70479", "l": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30601", "l": "3 AH2 + all-trans-neurosporene => 15-cis-phytoene + 3 A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875558", "l": "RAPGEF1 binds CRK,CRKL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429699", "l": "CERT [ER] + ceramide [ER] => CERT:ceramide [ER] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47625", "l": "cis-3-hydroxy-L-proline => 1-pyrroline-2-carboxylate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18022", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) => CMP + ganglioside GD1a (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18530", "l": "3-methylbutanol + NAD(+) => 3-methylbutanal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018541", "l": "p-benzoquinone reductase (NADPH) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31658", "l": "4-deoxy-Delta(4)-beta-D-GlcpA2S-(1->3)-beta-D-GalpNAc + H2O <=> 5-dehydro-4-deoxy-2-O-sulfo-D-glucuronate + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427514", "l": "eNoSC deacetylates histone H3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451418", "l": "Pellino ubiquitinates IRAK1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52147", "l": "3-phosphonopyruvate + acetyl-CoA + H2O <=> (R)-2-(phosphonomethyl)malate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388831", "l": "Phosphorylation of CD28 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62368", "l": "Fe(2+)(out) + 2 hydrogencarbonate(out) = Fe(2+)(in) + 2 hydrogencarbonate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14706", "l": "2 CoA + NADP(+) => CoA-disulfide + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59546", "l": "H2O2 + N,N'-diacetylchitobiono-1,5-lactone => N,N'-diacetylchitobiose + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450387", "l": "HuR binds the CRM1 nuclear export machinery (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61083", "l": "(+)-minovincinine + acetyl-CoA <=> (+)-echitovenine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671839", "l": "Phosphorylated STAT3 Dissociates from Leptin Receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5336184", "l": "GPR37L binds prosaposin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174097", "l": "Association of Emi1 with Cdh1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35561", "l": "menaquinol-7 + NAD(+) => H(+) + menaquinone-7 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.35"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23555", "l": "2-methylpropane-1,2-diol + NAD(+) <=> 2-hydroxy-2-methylpropanal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848023", "l": "Activated PTK6 binds STAP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22726", "l": "a sterol 3-beta-D-glucoside + H(+) + UDP => a sterol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043744", "l": "N2-acetyl-L-aminoadipate kinase activity"}, {"i": "RHEA:41944", "l": "[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP"}, {"i": "MetaCyc:RXN-5182"}, {"i": "EC:2.7.2.17", "l": "\"[Amino-group carrier protein]-L-2-aminoadipate 6-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382057", "l": "Release of novel PDGFs as latent factors (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001078", "l": "(1->6)-beta-D-glucan binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49027", "l": "L-tryptophan + O2 <=> 2-iminio-3-(indol-3-yl)propanoate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64855", "l": "benzoyl-CoA + octan-1-ol <=> CoA + octyl benzoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24677", "l": "ATP + cytidine <=> ADP + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989745", "l": "Expression of ACADM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9008043", "l": "MAPK8 phosphorylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19614", "l": "dimethyl sulfide + S-adenosyl-L-methionine => S-adenosyl-L-homocysteine + trimethylsulfonium"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58941", "l": "(1R,2R,3R)-prephytoene diphosphate + H(+) + NADH => all-trans-lycopaoctaene + diphosphate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23657", "l": "2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate => 3-carboxy-cis,cis-muconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33192", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62862", "l": "7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + 7 CO2 + 8 CoA + 2 H2O => acetyl-CoA + 7 H(+) + 7 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54689", "l": "alliin => 2-aminoprop-2-enoate + allylsulfenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.-.-.-", "l": "\"Transferases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1605724", "l": "Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035615", "l": "clathrin adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139895", "l": "tBID activates BAK protein (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17855", "l": "5-dehydro-D-fructose + H2O2 => keto-L-sorbose + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004800", "l": "thyroxine 5'-deiodinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41837", "l": "H(+) + hexanoyl-[ACP] + malonyl-[ACP] => 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11301", "l": "1D-5-O-methyl-myo-inositol + NAD(+) => 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17226", "l": "1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin] => 6-hydroxynicotinate + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4837364", "l": "Secretion of SOD3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10567", "l": "H2O + oxaloacetate 4-methyl ester <=> H(+) + methanol + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416683", "l": "SEMA3E binds to PLXND1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65625", "l": "hexadecanoyl-CoA + sphinga-(4E,8Z)-dienine => CoA + H(+) + N-hexadecanoylsphinga-(4E,8Z)-dienine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13409", "l": "7-aminomethyl-7-carbaguanine + 2 NADP(+) = 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH"}, {"i": "EC:1.7.1.13", "l": "\"PreQ(1) synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53062", "l": "estrone 4-O-(beta-D-glucuronate) + H(+) + UDP => 4-hydroxyestrone + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015640", "l": "peptidoglycan peptide transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755479", "l": "SUMOylation of NFKB2 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61847", "l": "solasodine + UDP-alpha-D-glucose <=> H(+) + solasodine 3-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.18", "l": "\"Exo-alpha-sialidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44843", "l": "(R)-carnitine + octadecanoyl-CoA <=> CoA + O-octadecanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706328", "l": "Active FLT3 binds to SOCS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5655483", "l": "USP1 autocleavage (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551683", "l": "SUMOylation of TOPORS with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047736", "l": "cellobiose epimerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30490", "l": "H(+) + N,N-dihydroxy-L-isoleucine <=> (1E,2S)-2-methylbutanal oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050083", "l": "malyl-CoA lyase activity"}, {"i": "MetaCyc:MALYL-COA-LYASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5658438", "l": "SPRED dimer binds NF1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10281", "l": "1,7-dimethylxanthine + S-adenosyl-L-methionine => caffeine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167083", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32675", "l": "alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose"}, {"i": "EC:3.2.1.28", "l": "\"Alpha,alpha-trehalase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674022", "l": "BRAP autoubiquitinates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42392", "l": "D-galactose + NAD(+) = D-galactono-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0030519", "l": "snoRNP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351341", "l": "Exocytosis of Proactivator polypeptide (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "44.908781913815353", "identifiers": [{"i": "GO:0005488", "l": "binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13937", "l": "4-sulfobenzoate + NADH + O2 = 3,4-dihydroxybenzoate + NAD(+) + sulfite"}, {"i": "EC:1.14.12.8", "l": "\"4-sulfobenzoate 3,4-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209828", "l": "Tryptophan is hydroxylated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52451", "l": "16alpha-hydroxyestrone + UDP-alpha-D-glucuronate <=> 16alpha-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4090281", "l": "PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14798", "l": "2-dehydro-3-deoxy-D-gluconate + ATP => 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686345", "l": "SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047782", "l": "coniferin beta-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166015", "l": "Association of LBP with LPS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.99.2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033161", "l": "mitogen-activated protein kinase kinase kinase kinase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203613", "l": "depalmitoylation of eNOS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165162", "l": "Phosphorylation of TSC2 by PKB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784622", "l": "APOA4,APOA5,APOC2,CIDEC,FGF21 genes express APOA4,APOA5,APOC2,CIDEC,FGF21 proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000137", "l": "CUBN:AMN transports extracellular CBLIF:Cbl to endosome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62272", "l": "4 (R)-2-hydroxy-3-methylbutyrate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + bassianolide + 8 diphosphate + 8 H(+) + 4 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47705", "l": "H(+) + iso-precytochalasin + NADPH + O2 => cytochalasin Z16 + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66802", "l": "2 H(+) + 3 H2O + miltiradien-20-al + 2 oxidized [NADPH--hemoprotein reductase] => miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34968", "l": "sn-glycerol 3-phosphate(in) => sn-glycerol 3-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39450", "l": "(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53721", "l": "ATP + N-acetyl-D-muramate => ADP + H(+) + N-acetyl-alpha-D-muramate 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50931", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 <=> (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654637", "l": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950456", "l": "IL12B dimerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052628", "l": "4-hydroxybenzoate amino acid synthetase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112271", "l": "The receptor:G-protein complex dissociates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990651", "l": "inositol-1,2,4,5,6-pentakisphosphate 5-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050216", "l": "propanediol-phosphate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65234", "l": "3-hydroxydodecanoate + CoA + H(+) => 3-hydroxydodecanoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132065", "l": "C1r activates C1s component within C1 complement complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102929", "l": "lachrymatory factor synthase activity"}, {"i": "MetaCyc:RXN-8911"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16227", "l": "N-(6-aminohexanoyl)-6-aminohexanoate => 1,8-diazacyclotetradecane-2,9-dione + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35046", "l": "N-(4-aminobenzoyl)-L-glutamate(in) <=> N-(4-aminobenzoyl)-L-glutamate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39234", "l": "3-oxo-triacontanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxytriacontanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60922", "l": "a cytidine in mRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + an N(3)-methylcytidine in mRNA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036104", "l": "Defective UGT1A4 does not transfer GlcA from UDP-GlcA to BMG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41955", "l": "2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate <=> [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102441", "l": "syringetin 7-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-13919"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5618107", "l": "ATP binding to HSP90 triggers conformation change (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61919", "l": "ATP + fluconazole(in) + H2O <=> ADP + fluconazole(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24624", "l": "ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)"}, {"i": "EC:6.1.1.3", "l": "\"Threonine--tRNA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865605", "l": "BRWD1 binds SMARCA4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0050263", "l": "ribosylpyrimidine nucleosidase activity"}, {"i": "RHEA:56816", "l": "a pyrimidine ribonucleoside + H2O = a pyrimidine nucleobase + D-ribose"}, {"i": "EC:3.2.2.8", "l": "\"Ribosylpyrimidine nucleosidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0050736", "l": "O-malonyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706340", "l": "Active FLT3:p-Y-GRB10 binds PIK3R1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23172", "l": "ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] = ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase]"}, {"i": "EC:2.7.11.31", "l": "\"[Hydroxymethylglutaryl-CoA reductase (NADPH)] kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66878", "l": "12-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63566", "l": "apelin-12 + L-phenylalanine => apelin-13 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42123", "l": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212356", "l": "Formation of CSL-NICD coactivator complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362486", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60672", "l": "NAD(+) + nerol = H(+) + NADH + neral"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26291", "l": "2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate => 2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.49"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32695", "l": "(2E)-geranyl diphosphate = (-)-car-3-ene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71783", "l": "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24885", "l": "(S)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+) <=> H(+) + L-glutamate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25617", "l": "terpentedienyl diphosphate = diphosphate + terpentetriene"}, {"i": "EC:4.2.3.36", "l": "\"Terpentetriene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4085992", "l": "SUMOylation of DAXX with SUMO1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28769", "l": "acetaldehyde + chemical entity + H(+) + nitrite => ethylnitronate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58494", "l": "ADP + Fe(III)-enterobactin(in) + H(+) + phosphate => ATP + Fe(III)-enterobactin(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39126", "l": "(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O <=> (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786257", "l": "DCTPP1 hydrolyses 5idCTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6781953", "l": "YOD1 binds VCP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863587", "l": "CDK5:p25 translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52067", "l": "13-(9Z-octadecenoyloxy)-octadecanoate + H2O <=> (9Z)-octadecenoate + 13-hydroxy-octadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18043", "l": "8 H(+) + nitrite + 6 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + NH4(+) + 6 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981497", "l": "ST3GAL1-4 can add a sialic acid to the T antigen at the alpha 3 position (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629358", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40554", "l": "demethylphylloquinol + S-adenosyl-L-methionine <=> H(+) + phylloquinol + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39219", "l": "3-oxooctacosanyol-CoA + H(+) + NADPH = (3R)-hydroxyoctacosanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9727349", "l": "XDH dehydrogenates xanthine to form urate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5205649", "l": "p62 links damaged mitochondria to LC3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592387", "l": "Fibulin binds elastic fibres (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29732", "l": "beta-maltose(in) => beta-maltose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36853", "l": "3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoA => (15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877192", "l": "RUNX1 binds FOXP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20380", "l": "3alpha-hydroxy-5alpha-androstan-17-one + NADP(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33456", "l": "4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) => CO2 + NADPH + zymosterone"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008885", "l": "glutathionylspermidine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56710", "l": "16alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15123", "l": "cis-1,2-dithiane-4,5-diol + 2 H(+) + hydrogen sulfide + sulfite => dithioerythritol + thiosulfate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050228", "l": "pterin deaminase activity"}, {"i": "MetaCyc:PTERIN-DEAMINASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26546", "l": "beta-alaninamide + H2O = beta-alanine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22746", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35703", "l": "1'-hydroxyversicolorone + H(+) + NADPH + O2 = (2S,3S)-versiconal hemiacetal acetate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22434", "l": "a 3-oxoacyl-CoA + H(+) + NADH => a (3S)-3-hydroxyacyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42341", "l": "4-(gamma-L-glutamylamino)butanal + H2O + NAD(+) => 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617182", "l": "PRKACA phosphorylates PLN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199161", "l": "Fc gamma receptors interact with antigen-bound IgG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1222376", "l": "NOX2 generates superoxide from oxygen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374699", "l": "UNC5A binds NRAGE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983259", "l": "Kinesins move along microtubules consuming ATP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797090", "l": "CCNK binds CDK12 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58504", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate = (3Z)-2-oxo-4-carboxy-3-hexenedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40856", "l": "FAD + H(+) + undecanoyl-CoA => FADH2 + trans-2-undecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61645", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L-arginine => 2 [Fe(III)-cytochrome b5] + H2O + L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66783", "l": "6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine + H2O <=> N-acetyl-D-glucosamine + N-acetyl-D-muramate 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204871", "l": "Interaction of Tie2 and Grb2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50837", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 => 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66550", "l": "4-nitrophenyl sulfate + adenosine 3',5'-bisphosphate => 3'-phosphoadenylyl sulfate + 4-nitrophenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16071", "l": "NH4(+) + uridine => cytidine + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51043", "l": "indole-3-pyruvate imine dimer <=> chromopyrrolate + H(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29375", "l": "AMP + H2O = adenosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624956", "l": "PDE6D binds INPP5E (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010427", "l": "abscisic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48574", "l": "(2E,4E)-2,4-dichloromuconate + 2 H(+) => 3,5-dichlorocatechol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33807", "l": "(E)-ferulate + H(+) = 2-methoxy-4-vinylphenol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444476", "l": "FPRL2 receptor binds a wide range of ligands (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031370", "l": "eukaryotic initiation factor 4G binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799350", "l": "Exocytosis of specific granule membrane proteins (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.419", "l": "\"Nepetalactol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030986", "l": "low molecular weight kininogen binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41672", "l": "1-O-hexadecyl-sn-glycerol + ATP = 1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39313", "l": "(3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+) => (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050304", "l": "nitrous-oxide reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685230", "l": "CHEK1 phosphorylates RAD51 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44313", "l": "1-tetradecanoylglycerol + H2O => glycerol + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216082", "l": "Interaction of integrin alphaXbeta2 with fibrin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13389", "l": "glutaryl-CoA + 2 H(+) + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein]"}, {"i": "EC:1.3.8.6", "l": "\"Glutaryl-CoA dehydrogenase (ETF)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003832", "l": "beta-alanyl-dopamine hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448661", "l": "IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47088", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2984258", "l": "NEK9 phosphorylates NEK6/NEK7 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404142", "l": "atROL binds RBP1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012203", "l": "miR-26A and B bind to the 3'UTR of the CHD11 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59918", "l": "(2E)-octenoate + 2 H(+) + NADPH => (2E)-octenal + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.77", "l": "\"Mannan 1,2-(1,3)-alpha-mannosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689861", "l": "Recruitment of XPA and release of CAK  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50281", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 => (5S)-hydroperoxy-(14R,15S)-epoxy-(6E,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63172", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA = (25R)-3-oxocholest-4-en-26-oyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17198", "l": "2 3-(4-hydroxyphenyl)pyruvate + O2 => 2 4-hydroxyphenylacetate + 2 CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43653", "l": "decanoyl-CoA + H(+) + malonyl-[ACP] => 3-oxododecanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57023", "l": "apulose + ATP <=> ADP + apulose 4-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48374", "l": "a fatty acid + acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) => 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9617595", "l": "SGTA binds mislocalized membrane protein (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875431", "l": "LRIG1 undergoes ubiquitination (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42921", "l": "S-adenosyl-L-methionine + uridine(1498) in 16S rRNA => H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28986", "l": "nitrite(in) <=> nitrite(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24121", "l": "H(+) + leukotriene E4 + NADPH + O2 => 20-hydroxy-leukotriene E4 + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40528", "l": "2 a ubiquinol + 4 H(+)(in) + O2(in) => 2 a ubiquinone + 4 H(+)(out) + 2 H2O(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0097027", "l": "ubiquitin-protein transferase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53109", "l": "2-hydroxyestrone + S-adenosyl-L-methionine => 2-hydroxy-3-methoxy-estrone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60116", "l": "2-oxoglutarate + methylphosphonate + O2 = CO2 + hydroxymethylphosphonate + succinate"}, {"i": "EC:1.14.11.71", "l": "\"Methylphosphonate hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58556", "l": "15alpha-stemmadenine intermediate II + H2O = (16S)-deshydroxymethyl-stemmadenine + formate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76500", "l": "TBXAS1 isomerises PGH2 to TXA2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6813740", "l": "GDE1 hydrolyzes GroPIns (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24288", "l": "5-formimidoyltetrahydrofolate + glycine = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine"}, {"i": "EC:2.1.2.4", "l": "\"Glycine formimidoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46403", "l": "cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-cholest-5-ene-3beta,26-diol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798374", "l": "DYRK2 phosphorylates TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57330", "l": "CoA + H(+) + N-terminal N-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein] => acetyl-CoA + N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.147", "l": "\"Thioglucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61669", "l": "ATP + CoA + salicylate => 2-hydroxybenzoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54137", "l": "cytidine(48) in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine(48) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018746", "l": "RHOQ binds effectors at the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30926", "l": "(R)-glycerate + ADP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8867344", "l": "OMA1 hydrolyses OPA1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21511", "l": "all-trans-retinyl hexadecanoate + H2O <=> H(+) + hexadecanoate + retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708466", "l": "BACH1 translocates from the nucleoplasm to the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42440", "l": "L-aspartate + NAD(+) = H(+) + iminosuccinate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617596", "l": "BAG6:GET4:UBL4A binds mislocalized membrane protein:SGTA and ASNA1:ATP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112755", "l": "SOCS3 binds IL6ST (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2509831", "l": "ITPA hydrolyses XTP to XMP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013143", "l": "RAC1 GEFs activate RAC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102648", "l": "D-ribose 5-phosphate:D-fructose 6-phosphate transaldolase activity"}, {"i": "MetaCyc:RXN-15790"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648883", "l": "p-T-EIF2AK1:ferriheme dimer autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31908", "l": "(S)-norcoclaurine + S-adenosyl-L-methionine => (S)-coclaurine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46258", "l": "2 [Fe(III)-cytochrome b5] + a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 H2O => 2 [Fe(II)-cytochrome b5] + a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43033", "l": "3-chloro-D-alanine => 2-aminoprop-2-enoate + chloride + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482772", "l": "Release of platelet cytosolic components (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22716", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.25", "l": "\"Cholesterol 24-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49357", "l": "2'-hydroxy-2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2',2'-dihydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62681", "l": "YWA1 => H(+) + H2O + norrubrofusarin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1299359", "l": "Activation of TALK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66879", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 12-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005117", "l": "wishful thinking binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51910", "l": "dADP + H(+) + phosphate => dATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46749", "l": "carboxyphosphate + NH4(+) => carbamate + 2 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27380", "l": "(R)-glycerate + ATP <=> (2R)-2-phosphoglycerate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10290", "l": "H(+) + L-rhamnonate => H2O + L-rhamnono-1,4-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166542", "l": "beta-NGF dimer binds to TrkA receptor (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42569", "l": "2,3-dihydroxy-p-cumate + O2 => 3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51949", "l": "(2S)-2-methylbutanenitrile + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2-methylbutanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424484", "l": "Phosphorylation of BTK by p-SYK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30274", "l": "2 (3,4-dimethoxyphenyl)methanol + H2O2 <=> 2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50701", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => calcitriol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047383", "l": "guanidinodeoxy-scyllo-inositol-4-phosphatase activity"}, {"i": "KEGG.REACTION:R03496"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669868", "l": "Nilotinib-resistant KIT mutants do not bind nilotinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16791", "l": "a 2-oxocarboxylate + H2O2 => a (2S)-2-hydroxycarboxylate + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "65.166422153683129", "identifiers": [{"i": "GO:0140101", "l": "catalytic activity, acting on a tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63692", "l": "alcohol glucuronate acceptor + UDP-alpha-D-glucuronate = a beta-D-glucuronoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021949", "l": "MEF2C gene expression is inhibited by MECP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34229", "l": "2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H(+) + nitrite => 5-nitrosalicylate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51545", "l": "D-ribulose => D-xylulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42692", "l": "[(1->4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate = [(1->4)-alpha-D-glucosyl](n+2) + phosphate"}, {"i": "EC:2.4.99.16", "l": "\"Starch synthase (maltosyl-transferring)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59302", "l": "adenosine 3',5'-bisphosphate + firefly D-sulfoluciferin + H(+) => 3'-phosphoadenylyl sulfate + firefly D-luciferin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2029456", "l": "RAC1 and CDC42 activate PAK1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23760", "l": "H(+) + H2 + oxidized coenzyme F420-(gamma-Glu)(n) = reduced coenzyme F420-(gamma-Glu)(n)"}, {"i": "EC:1.12.98.1", "l": "\"Coenzyme F420 hydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005220", "l": "inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008979", "l": "prophage integrase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990538", "l": "xylan O-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13658", "l": "acetyl-[citrate lyase ACP] + H2O => acetate + H(+) + holo-[citrate lyase ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371422", "l": "ATP hydrolysis by HSP70 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43577", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13301", "l": "a 1,2-diacyl-sn-glycerol + a sterol = a 1-acyl-sn-glycerol + a sterol ester"}, {"i": "EC:2.3.1.73", "l": "\"Diacylglycerol--sterol O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32923", "l": "H2O + sn-glycero-3-phospho-(1'-sn-glycerol) = glycerol + H(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21212", "l": "H2O + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] = 4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362437", "l": "C-terminal Hh fragments are bound by lectins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28290", "l": "(2E,6E)-farnesyl diphosphate + H2O = (5S,9S,10S)-drim-7-en-11-ol + diphosphate"}, {"i": "EC:4.2.3.194", "l": "\"(-)-drimenol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1980125", "l": "ITCH binds DTX (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15196", "l": "dGTP + H2O <=> 2'-deoxyguanosine + H(+) + triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17186", "l": "IMP + NADP(+) + NH4(+) => GMP + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483219", "l": "PC is exchanged with PI by PITPNB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5658438", "l": "SPRED dimer binds NF1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050325", "l": "tauropine dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30528", "l": "H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate => ADP + ATP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10463", "l": "prostaglandin A1 <=> prostaglandin C1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21246", "l": "an 8-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine => an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54428", "l": "4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O = ADP-D-ribose + H(+) + L-aspartyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010471", "l": "GDP-galactose:mannose-1-phosphate guanylyltransferase activity"}, {"i": "MetaCyc:RXN4FS-12"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75856", "l": "Abortive Initiation Before Second Transition (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952807", "l": "p-Y693-STAT4 dissociates after IL12:IL12R interaction (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102485", "l": "dATP phosphohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33474", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-(4R)-4-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983394", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47999", "l": "1,6-dihydro-beta-NAD + H(+) + O2 <=> H2O2 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77094", "l": "Formation of cap binding complex (CBC) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030346", "l": "protein phosphatase 2B binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928576", "l": "RHOA:GTP binds ROCK, activating it (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433542", "l": "Phosphorylation and activation of VAV1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5631941", "l": "SESN1,2,3 bind AMPK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55321", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => 2-heptanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl heptanoate + apo--[retinol-binding protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60650", "l": "an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine => an N-(acyl)-sphingosylphosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37192", "l": "2',3'-cyclic AMP + H2O => adenosine 2'-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.218", "l": "\"Phenylpropanoylacetyl-CoA synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008478", "l": "FBXW7 binds RUNX2 and GSK3B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46042", "l": "ADP + dCMP + H(+) => 2'-deoxycytidine + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52853", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin] => 6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20881", "l": "10-hydroxydecanoate + NAD(+) => 10-oxodecanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11137", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate => a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084507", "l": "Laminin-111 binds endostatin dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036127", "l": "3-sulfino-L-alanine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38951", "l": "ATP + H2O + sphing-4-enine 1-phosphate(in) = ADP + H(+) + phosphate + sphing-4-enine 1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984001", "l": "IL35 binds IL27RA:IL12RB2 receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75146", "l": "TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55739", "l": "alpha-D-galacturonosyl-[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n) + UDP-beta-L-rhamnose <=> [(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693761", "l": "FA2H hydroxylates CERA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62961", "l": "cholesta-5,7-dien-3beta-ol(in) => cholesta-5,7-dien-3beta-ol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47100", "l": "choloyl-CoA + taurine = CoA + H(+) + taurocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60107", "l": "3-(1H-indol-3-yl)propanoate + H(+) + oxidized [electron-transfer flavoprotein] <=> (E)-3-(indol-3-yl)acrylate + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40661", "l": "1-O-hexadecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9677579", "l": "CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190693", "l": "Synthesis of GJB1 (Cx32) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35298", "l": "adenylyl-molybdopterin + H(+) + tungstate <=> AMP + H2O + W-molybdopterin cofactor"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20669", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NAD(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19437", "l": "nicotinate + UDP-alpha-D-glucose = N-(beta-D-glucosyl)nicotinate + UDP"}, {"i": "EC:2.4.1.196", "l": "\"Nicotinate glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682769", "l": "LGI2 binds ADAM22,23 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58327", "l": "beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14927", "l": "D-mannose 6-phosphate + H(+) + NADPH => D-mannitol 1-phosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102852", "l": "1-18:3-2-16:0-phosphatidylglycerol desaturase activity"}, {"i": "MetaCyc:RXN-8319"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13922", "l": "ent-kaur-16-en-19-oate + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => gibberellin A12 aldehyde + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31227", "l": "di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701507", "l": "PTPN6 dephosphorylates JAK3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63683", "l": "(7R,8S)-7,8-diammoniononanoate + CO2 <=> (7R,8S)-8-amino-7-(carboxyamino)nonanoate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507868", "l": "Aquaporins passively transport water into cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56251", "l": "1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> 2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26246", "l": "geranylgeranyl diphosphate => diphosphate + fusicocca-2,10(14)-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004526", "l": "ribonuclease P activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52538", "l": "AMP + dGDP + H(+) => adenosine + dGTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51356", "l": "H2O + N-(9Z-octadecenoyl)-L-glutamine = (9Z)-octadecenoate + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41909", "l": "(3R)-hydroxyhexadecanoyl-[ACP] => (2E)-hexadecenoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.69", "l": "\"SARS coronavirus main proteinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59247", "l": "3''-O-acetyl-ADP-D-ribose + H2O <=> acetate + ADP-D-ribose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15985", "l": "formate + NAD(+) = CO2 + NADH"}, {"i": "EC:1.17.1.9", "l": "\"Formate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5339535", "l": "GLTPD1 transports C1P from plasma membrane to Golgi membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38685", "l": "ADP + H(+) + phosphate + sphing-4-enine(out) => ATP + H2O + sphing-4-enine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55846", "l": "calcidiol 3-O-(beta-D-glucuronide) + H(+) + UDP => calcidiol + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47029", "l": "[DsrC protein]-S-sulfo-L-cysteine/L-cysteine => [DsrC protein]-disulfide + H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809254", "l": "MTMR8 binds MTMR9 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983144", "l": "Transport of Antigen peptide in to ER (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42309", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33104", "l": "(2E,6E)-farnesyl diphosphate => alpha-muurolene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48328", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose = GDP + H(+) + III(4)-a-Fuc-Lc4Cer(d18:1(4E))"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106317", "l": "methane monooxygenase NADH activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205306", "l": "Interaction of SHP1 and KIT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110518", "l": "Activated DTOR also phosphorylates D4EBP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5340226", "l": "CYGB dioxygenates NO (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0019171", "l": "3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"}, {"i": "RHEA:13097", "l": "a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O"}, {"i": "EC:4.2.1.59", "l": "\"3-hydroxyacyl-[acyl-carrier-protein] dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40806", "l": "3,6-anhydro-alpha-L-galactopyranose + H2O + NADP(+) <=> 3,6-anhydro-L-galactonate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29322", "l": "H2O + sn-glycero-3-phosphoethanolamine <=> ethanolamine + H(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004823", "l": "leucine-tRNA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14279", "l": "(S)-lactate + 2 H(+) + NADH => (S)-lactaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17441", "l": "2-oxoglutarate + L-cysteine = 2-oxo-3-sulfanylpropanoate + L-glutamate"}, {"i": "EC:2.6.1.3", "l": "\"Cysteine transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2995330", "l": "COX10 transforms heme to heme O (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49842", "l": "(-)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+) => (-)-dehydrodiconiferyl acid + 2 a quinone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48949", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate => 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26268", "l": "dehydroabietadienal + H2O + NADP(+) <=> dehydroabietate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10542", "l": "6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde => 7,8-dihydroneopterin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167197", "l": "Separation of elongating HIV-1 transcript from template (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26236", "l": "(2E,6E,10E)-geranylgeraniol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + plaunotol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618107", "l": "ATP binding to HSP90 triggers conformation change (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72663", "l": "De novo formation of eIF2:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-169828", "l": "Activated DAkt1 phosphorylates TSC2 which inhibits the TSC1/2 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2509838", "l": "ITPA hydrolyses dITP to dIMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56897", "l": "a carboxylate + ATP + H(+) => an acyl-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-74723", "l": "Endosome acidification (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12986", "l": "GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31379", "l": "H2O + pyrrole-2-carboxylate = 1H-pyrrole + hydrogencarbonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199299", "l": "AKT phosphorylates FOXO transcription factors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25513", "l": "(2S)-2-amino-4-deoxychorismate + L-glutamate => chorismate + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451377", "l": "Interaction of IQGAP1 with nephrin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696958", "l": "USP44 deubiquitinates CDC20 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032450", "l": "maltose alpha-glucosidase activity"}, {"i": "MetaCyc:RXN-2141"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34426", "l": "(-)-secoisolariciresinol + NADP(+) <=> (+)-lariciresinol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25570", "l": "ADP + H(+) + nicotinate beta-D-ribonucleotide => ATP + beta-D-ribosylnicotinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848829", "l": "CBL autoubiquitinates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42506", "l": "6-acetamido-2-oxohexanoate + L-glutamate => 2-oxoglutarate + N(6)-acetyl-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54415", "l": "a 3-oxo-5beta-steroid + NADP(+) <=> a 3-oxo-Delta(4)-steroid + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57722", "l": "ADP + 5 H(+)(out) + phosphate => ATP + 4 H(+)(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606789", "l": "ARSB hydrolyses DS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "67.107963008379755", "identifiers": [{"i": "GO:0016881", "l": "acid-amino acid ligase activity"}, {"i": "EC:6.3.2.-", "l": "\"Acid--amino-acid ligases (peptide synthases)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061501", "l": "2',3'-cyclic GMP-AMP synthase activity"}, {"i": "REACT:R-HSA-3244614", "l": "cGAS produces cyclic GMP-AMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909552", "l": "Phosphorylation of STAT1 at Ser727 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102937", "l": "16-alpha-hydroxygypsogenate-UDP-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-9014"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63193", "l": "[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + O2 => glycine betaine + 2 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.134", "l": "\"Beta-amyrin 24-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30399", "l": "alpha-carotene + O2 + reduced [NADPH--hemoprotein reductase] = alpha-cryptoxanthin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "RHEA:57352", "l": "O2 + reduced [NADPH--hemoprotein reductase] + zeinoxanthin = H(+) + H2O + lutein + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.158", "l": "\"Carotene epsilon-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3325546", "l": "Defective CD320 does not transport extracellular TCII:Cbl to endosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50060", "l": "ATP + glycochenodeoxycholate(in) + H2O = ADP + glycochenodeoxycholate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446694", "l": "IRAK4 phosphorylates IRAK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.51", "l": "\"HycI peptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45414", "l": "glycerol + H(+) + prostaglandin D2 => H2O + prostaglandin D2-1-glycerol ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1013020", "l": "Activation of GIRK/Kir3 Channels (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373732", "l": "Nephrin trans-homophilic interaction (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11934", "l": "acetone + hydrogen cyanide => 2-hydroxy-2-methylpropanenitrile"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043898", "l": "2,3-dihydroxybiphenyl 1,2-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57551", "l": "(S)-beta-macrocarpene + O2 + reduced [NADPH--hemoprotein reductase] <=> [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45457", "l": "H2O + N-dodecanoylethanolamine => dodecanoate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53435", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19525", "l": "(2E,6E)-farnesyl diphosphate = (1S,8aR)-delta-cadinene + diphosphate"}, {"i": "EC:4.2.3.13", "l": "\"(+)-delta-cadinene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102517", "l": "oleate 12-hydroxylase activity"}, {"i": "MetaCyc:RXN-14487"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59012", "l": "cycloartenol + S-adenosyl-L-methionine = 24-methylenecycloartanol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031801", "l": "type 4 metabotropic glutamate receptor binding"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0001161", "l": "intronic transcription regulatory region sequence-specific DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5159250", "l": "ATF7IP binds SETDB1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694337", "l": "Trimmed spike protein binds to calnexin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2172123", "l": "Interaction of SIGLEC14/15/16 and DAP12 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004558", "l": "alpha-1,4-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110307", "l": "REV1 binds AP-dsDNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.n3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051075", "l": "S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59881", "l": "4-hydroxyphenylacetate + FMNH2 + O2 => 3,4-dihydroxyphenylacetate + FMN + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371582", "l": "HSBP1 binds HSF1 trimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937792", "l": "RUNX3 binds SRC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75079", "l": "Formation of AT-AC C complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43849", "l": "[thioredoxin]-dithiol + arsenate + H(+) => [thioredoxin]-disulfide + arsenite + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9692880", "l": "HRH3 binds Hist (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389839", "l": "39S subunit binds 28S subunit:mRNA:fMet-tRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25586", "l": "beta-L-rhamnose => alpha-L-rhamnose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52873", "l": "17alpha-estradiol + UDP-alpha-D-glucuronate => 17alpha-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44034", "l": "9,10-dihydroxy-(12Z)-octadecenoate => 9,10-epoxy-(12Z)-octadecenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422320", "l": "Heterotrimeric G(s) complex dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416929", "l": "PTGFR binds PGF2a (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31470", "l": "beta-D-glucosyl crocetin + UDP-alpha-D-glucose <=> bis(beta-D-glucosyl) crocetin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64227", "l": "AH2 + O2 + uridine(34) in tRNA <=> 5-hydroxyuridine(34) in tRNA + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975125", "l": "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33247", "l": "O2 + putrescine = 1-pyrroline + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44438", "l": "a triacylglycerol + glycerol => a 1,2-diacylglycerol + a 1-acylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434073", "l": "IRAK4 recruitment to the activated TLR complexed with ligand, TIRAP and MyD88  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437234", "l": "Heat-Stable Antigen binds L1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31225", "l": "beta-D-glucose + cis-2-coumarate => cis-beta-D-glucosyl-2-hydroxycinnamate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65570", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39900", "l": "7-deoxyloganetin + UDP-alpha-D-glucose => 7-deoxyloganin + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635868", "l": "ub-GLI is degraded by the proteasome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693198", "l": "RHOD binds effectors at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46249", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 => (14Z)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60298", "l": "H(+) + N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21933", "l": "S-adenosyl-L-methionine => homoserine lactone + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29539", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}, {"i": "EC:2.4.1.261", "l": "\"Dolichyl-P-Man:Man(8)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2129375", "l": "Elastin cross-linking by lysyl oxidase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25120", "l": "H2O + L-lysine + NAD(+) <=> (S)-2-amino-6-oxohexanoate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712208", "l": "odorant:Olfactory Receptor:GNAL:GTP:GNB1:GNG13 dissociates yielding GNAL:GTP (G alpha-olf:GTP), odorant:OlfactoryReceptor, and GNB1:GNG13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16584", "l": "2 [Fe(II)cytochrome c] + 2 H(+) + H2O2 <=> 2 [Fe(III)cytochrome c] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53545", "l": "chlorophyll a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 7(1)-hydroxychlorophyll a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14621", "l": "(S)-2,3-epoxysqualene = lanosterol"}, {"i": "EC:5.4.99.7", "l": "\"Lanosterol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9659515", "l": "CACNA1D:CACNA2D2:CACNB2 (Cav1.3 channel) transports Ca2+ into the cytosol of an inner hair cell (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031699", "l": "beta-3 adrenergic receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193702", "l": "Part of the ICD migrates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37522", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047243", "l": "flavanone 7-O-beta-glucosyltransferase activity"}, {"i": "RHEA:65152", "l": "(2S)-naringenin + UDP-alpha-D-glucose = (2S)-naringenin 7-O-beta-D-glucoside + H(+) + UDP"}, {"i": "RHEA:65244", "l": "(2S)-hesperetin + UDP-alpha-D-glucose = (2S)-hesperetin 7-O-beta-D-glucoside + H(+) + UDP"}, {"i": "MetaCyc:2.4.1.185-RXN"}, {"i": "EC:2.4.1.185", "l": "\"Flavanone 7-O-beta-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046817", "l": "chemokine receptor antagonist activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44939", "l": "(9Z,12Z,15Z)-octadecatrienoate + ATP + CoA <=> (9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046876", "l": "3,4-didehydroretinal binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53790", "l": "allodeoxycholate + beta-muricholoyl-CoA => allodeoxycholoyl-CoA + beta-muricholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62375", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA <=> (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392748", "l": "L1 binds to AP-2 Clathrin complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22697", "l": "AH2 + androst-4-ene-3,17-dione + O2 => A + H2O + testololactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674542", "l": "p-Y-STAT1,3,5 dimerize (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18082", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + pentalenene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64251", "l": "decanoyl-CoA + glycine <=> CoA + H(+) + N-decanoylglycine"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0004722", "l": "protein serine/threonine phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9660557", "l": "RAS:GTP binds RAL GDS proteins (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43174", "l": "N(7)-methylguanosine(1575) in yeast 18S rRNA + S-adenosyl-L-homocysteine => guanosine(1575) in yeast 18S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51290", "l": "(13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45747", "l": "(6S)-5,6,7,8-tetrahydropteroate + NAD(+) <=> 7,8-dihydropteroate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31030", "l": "2-trans-(+)-abscisate + UDP-alpha-D-glucose <=> beta-D-glucopyranosyl trans-(+)-abscisate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43632", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) = an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33818", "l": "CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate <=> 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9631068", "l": "HSPA8:substrate binds late endosomal phospholipids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428625", "l": "Vesicular inhibitory amino acid transport (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017130", "l": "poly(C) RNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20506", "l": "an alpha-(gamma-L-glutamyl)-L-amino acid => 5-oxo-L-proline + an L-alpha-amino acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55006", "l": "3-isopropenyl-6-oxoheptanoate + H2O + NADP(+) => 1-hydroxylimonen-2-one + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164508", "l": "N and C terminal heptad repeat helices of gp41 form six-helix bundle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852331", "l": "GTSE1 translocates to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34936", "l": "2 ATP + H(+) => diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50214", "l": "11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0030292", "l": "protein tyrosine kinase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693598", "l": "ATM phosphorylates NBN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1011598", "l": "DOCKs bind to RhoGEFs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14198", "l": "ATP + L-aspartate + NH4(+) => ADP + H(+) + L-asparagine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22039", "l": "[phosphate](n) + D-glucose <=> [phosphate](n-1) + D-glucose 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174444", "l": "Formation of C-strand Okazaki fragments (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26473", "l": "(E)-feruloyl-CoA + 16-hydroxyhexadecanoate <=> 16-feruloyloxyhexadecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420202", "l": "Secretin receptor binds secretin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37062", "l": "adenosine(37) in tRNA + L-threonylcarbamoyladenylate <=> AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66027", "l": "hypobromite + L-lysyl-[collagen] + L-methionyl-[collagen] <=> [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047376", "l": "all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50394", "l": "5a,11a-dehydrooxytetracycline + reduced coenzyme F420-(gamma-Glu)(n) => H(+) + oxidized coenzyme F420-(gamma-Glu)(n) + oxytetracycline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.15", "l": "\"Carboxypeptidase A2\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50457", "l": "prostaglandin H3 => prostaglandin D3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351341", "l": "Exocytosis of Proactivator polypeptide (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45160", "l": "3-oxopropanoate + H(+) = acetaldehyde + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10537", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O => 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050280", "l": "sequoyitol dehydrogenase activity"}, {"i": "RHEA:11300", "l": "1D-5-O-methyl-myo-inositol + NAD(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH"}, {"i": "EC:1.1.1.143", "l": "\"Sequoyitol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0043364", "l": "glycyl-radical enzyme activating activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60701", "l": "a 1-acyl-sn-glycero-3-phosphocholine => a 1-acyl-sn-glycero-2,3-cyclic phosphate + choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25104", "l": "ATP + pyridoxamine = ADP + H(+) + pyridoxamine 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31983", "l": "abieta-7,13-dien-18-ol + O2 + reduced [NADPH--hemoprotein reductase] = abieta-7,13-dien-18,18-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.-", "l": "\"Endopeptidases of unknown catalytic mechanism\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381109", "l": "IRE1 binds IRE1 forming dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421517", "l": "Transport of delta-aminolevulinate from the mitochondrial matrix to the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.87", "l": "\"ADAMTS13 endopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69891", "l": "Phosphorylation and activation of CHEK2 by ATM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102877", "l": "alpha-copaene synthase activity"}, {"i": "RHEA:33991", "l": "(2E,6E)-farnesyl diphosphate = alpha-copaene + diphosphate"}, {"i": "EC:4.2.3.133", "l": "\"Alpha-copaene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854408", "l": "APOBR dimer binds VLDLs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53507", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004092", "l": "carnitine O-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955844", "l": "RBKS phosphorylates ribose to R5P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.41", "l": "\"Isocitrate dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868260", "l": "CDK5:p25 phosphorylates GOLGA2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21041", "l": "CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77077", "l": "Capping complex formation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61272", "l": "H2O + L-2-aminopentanoate + O2 = 2-oxopentanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31135", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + diphosphate = 5-amino-4-imidazolecarboxyamide + 5-phospho-alpha-D-ribose 1-diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39124", "l": "(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O => (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "78.047734625335977", "identifiers": [{"i": "GO:0016824", "l": "hydrolase activity, acting on acid halide bonds"}, {"i": "EC:3.8.-.-", "l": "\"Acting on halide bonds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10838", "l": "demethylsulochrin + NADP(+) => NADPH + O2 + questin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139898", "l": "Caspase-8 activates BID by cleavage (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53138", "l": "5alpha-dihydrotestosterone sulfate + H(+) + NADPH => (3beta,5alpha,17beta)-3-hydroxy-androstan-17-yl sulfate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23846", "l": "ADP + D-sedoheptulose 7-phosphate + H(+) => ATP + sedoheptulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47317", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10231", "l": "citrate <=> cis-aconitate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684267", "l": "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.5", "l": "\"Xylose isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051916", "l": "granulocyte colony-stimulating factor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11960", "l": "2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate = (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate"}, {"i": "EC:2.6.1.17", "l": "\"Succinyldiaminopimelate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928619", "l": "PAK1 binds RAC1:GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21434", "l": "H(+) + NADH + oxaloacetate => (S)-malate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14408", "l": "D-glucose + NADP(+) <=> D-glucono-1,5-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050193", "l": "phosphoketolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64221", "l": "H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675417", "l": "PEBP1 binds activated RAF1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41725", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => (11R)-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23547", "l": "a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-alpha-D-glucose <=> a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24806", "l": "(2S)-2-acetolactate + thiamine diphosphate => 2-(1-hydroxyethyl)thiamine diphosphate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22768", "l": "4-nitrophenyl-3-ketovalidamine = 4-nitroaniline + 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one"}, {"i": "EC:4.3.3.1", "l": "\"3-ketovalidoxylamine C-N-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210273", "l": "Interaction of DAP12 and NKp44 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58004", "l": "(20S)-ginsenoside F2 + UDP-alpha-D-glucose = (20S)-ginsenoside Rd + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167684", "l": "Active PLCG1 dissociates from TrkA receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14857", "l": "(indol-3-yl)acetate + ATP + L-lysine = ADP + H(+) + N(6)-[(indole-3-yl)acetyl]-L-lysine + phosphate"}, {"i": "EC:6.3.2.20", "l": "\"Indoleacetate--lysine synthetase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14091", "l": "glyoxylate + L-glutamate => 2-oxoglutarate + glycine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043840", "l": "branched-chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity"}, {"i": "MetaCyc:RXN-7708"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800798", "l": "The PIDDosome binds CASP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710354", "l": "GSDME (1-270) binds cardiolipin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21865", "l": "an S-(2-hydroxyacyl)glutathione + H2O => a 2-hydroxy carboxylate + glutathione + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9659820", "l": "RB1 translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204824", "l": "Interaction of Tie2 and Ang4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46545", "l": "2 [Fe(II)-cytochrome b5] + an N-acylsphinganine + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + an N-acylsphing-4-enine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30722", "l": "acetyl-CoA + propanoyl-CoA <=> 2-methyl-3-oxobutanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0005509", "l": "calcium ion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37117", "l": "CoA + H(+) + N-tetracosanoyl-sphing-4-enine => sphing-4-enine + tetracosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36316", "l": "2 H(+) + hexadecanoyl-CoA + 2 NADPH => CoA + hexadecan-1-ol + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061768", "l": "magnesium:sodium antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61475", "l": "a sphingoid base + hexadecanoyl-CoA <=> an N-hexadecanoyl-sphingoid base + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16324", "l": "(S)-indan-1-ol + NADP(+) <=> H(+) + indan-1-one + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44649", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O => a 2-acyl-sn-glycerol 3-phosphate + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49531", "l": "(ethylene terephthalate)(n) + H2O <=> (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-981814", "l": "GalNAc alpha-2,6-sialyltransferase II can add a sialic acid to the T antigen at the alpha 6 position (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29602", "l": "monacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + monacolin J carboxylate + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018677", "l": "pentachlorophenol monooxygenase activity"}, {"i": "MetaCyc:PCP4MONO-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56252", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-seryl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102126", "l": "coniferyl aldehyde 5-hydroxylase activity"}, {"i": "MetaCyc:RXN-1142"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45047", "l": "2 [Fe(II)cytochrome c] + H(+) + nitroxyl + O2 <=> 2 [Fe(III)cytochrome c] + H2O + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54676", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (+)-kolavenyl diphosphate"}, {"i": "EC:5.5.1.29", "l": "\"(+)-kolavenyl diphosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683355", "l": "Defective ABCB6 does not transport porphyrin from cytosol into mitochondria matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420975", "l": "Ca impermeable AMPA receptor ligand binding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956025", "l": "AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098607", "l": "methylselenocysteine deselenhydrase activity"}, {"i": "REACT:R-HSA-2408539", "l": "MeSec is hydrolysed to MeSeH by PXLP-K212-CTH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29822", "l": "ATP + H2O + L-isoleucine(out) <=> ADP + H(+) + L-isoleucine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623558", "l": "Defective SLC11A2 does not cotransport Fe2+, H+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016761", "l": "cellulose synthase (GDP-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2173318", "l": "C5a anaphylatoxin binds C5a receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67075", "l": "a very long-chain fatty acyl-CoA + H2O <=> a very long-chain fatty acid + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32822", "l": "chromate(in) <=> chromate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709831", "l": "HSP90 binds TBK1 and IRF3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46696", "l": "a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427570", "l": "Group 3 - Selective Cl- transport (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40522", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16933", "l": "1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH4(+)"}, {"i": "EC:3.5.99.7", "l": "\"1-aminocyclopropane-1-carboxylate deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5665871", "l": "ADRM1 binds 26S proteasome (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52830", "l": "(3S,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+) => (1S,4R)-isodihydrocarvone + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211461", "l": "HNF1A-dependent synthesis of the L isoform of PKLR protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675198", "l": "Activated MAPKs phosphorylate BRAF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59003", "l": "H2O + O2 + propanal <=> H(+) + H2O2 + propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54305", "l": "n 3'-phosphoadenylyl sulfate + dermatan 4'-sulfate => n adenosine 3',5'-bisphosphate + dermatan 4',6'-disulfate + n H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109702", "l": "PDPK1 phosphorylates AKT2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-921155", "l": "p-STAT5 dissociates from the receptor complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32827", "l": "ATP + H2O + methionine(out) = ADP + H(+) + methionine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014433", "l": "RHOG GEFs activate RHOG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60466", "l": "2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) => 2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54352", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.26"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21007", "l": "(R)-pantolactone + A <=> 2-dehydropantolactone + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013438", "l": "RHOD binds effectors at the endosome membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193702", "l": "Part of the ICD migrates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33821", "l": "3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]pyruvate => 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23178", "l": "acetyl-CoA + AMP + diphosphate => acetate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24395", "l": "dTDP-L-dihydrostreptose + streptidine 6-phosphate <=> dTDP + H(+) + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442592", "l": "WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001605", "l": "adrenomedullin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56417", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate => alpha-D-glucose 1-phosphate + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57533", "l": "5'-end ribonucleotide-RNA + ATP + H(+) => adenosine-5'-diphospho-5'-ribonucleotide-RNA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36691", "l": "octadecanoyl-CoA + sphing-4-enine = CoA + H(+) + N-octadecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606288", "l": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24471", "l": "H(+) + N,N-dimethylaniline + NADPH + O2 <=> H2O + N,N-dimethylaniline N-oxide + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202713", "l": "CD84 homodimerises (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53219", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha,17alpha-dihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39816", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + octadecanoate => 2-hydroxyoctadecanoate + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944242", "l": "Association of procollagen type XXVII (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51658", "l": "keto-D-fructuronate => keto-D-tagaturonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43596", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 = 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9724685", "l": "IgE binds omalizumab (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071207", "l": "histone pre-mRNA stem-loop binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2301205", "l": "SETD8 monomethylates histone H4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863973", "l": "Fusion of ERC and phagosome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10757", "l": "ATP + phosphate + pyruvate => AMP + diphosphate + H(+) + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0050485", "l": "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor"}, {"i": "EC:1.21.4.-", "l": "\"With a disulfide as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43403", "l": "N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose <=> H(+) + N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19461", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP = 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4341048", "l": "SUMOylation of RXRA with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22422", "l": "2 H(+) + maleylacetate + NADH => cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39757", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200646", "l": "Cytosolic folate export across the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1297444", "l": "Binding of cAMP to HCN channels (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51003", "l": "[fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine <=> [fructose-bisphosphate aldolase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442938", "l": "activated MAPK3/MAPK6 migrates to nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357828", "l": "RIPK1 is cleaved by CASP8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170674", "l": "Dissociation of the Gi alpha:G olf complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40774", "l": "(20S)-ginsenoside Rg1 + H2O <=> (20S)-ginsenoside F1 + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45798", "l": "acetoacetyl-CoA + H(+) + NADPH => (3R)-3-hydroxybutanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28516", "l": "(R)-carnitinyl-CoA + AMP + diphosphate => (R)-carnitine + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51981", "l": "an L-N,N-dihydroxypolyhomomethionine + H(+) => an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432712", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69127", "l": "Formation of the Flap Intermediate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31184", "l": "acetyl-CoA + decanoyl-CoA => 3-oxododecanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3779381", "l": "H2O2 diffuses from the mitochondrial matrix to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848713", "l": "PTK6 binds BCAR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56536", "l": "(12R)-hydroxy-(9Z)-octadecenoyl-CoA + 1,2-di-(12R-hydroxy-9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(12R-hydroxy-9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19636", "l": "(3S,5S)-3,5-diaminohexanoate + H2O + NAD(+) <=> (5S)-5-amino-3-oxohexanoate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070300", "l": "phosphatidic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25313", "l": "glyoxylate + H2O2 => glycolate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.49", "l": "\"1-pyrroline-2-carboxylate reductase (NAD(P)H)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39231", "l": "3-oxo-triacontanoyl-CoA + H(+) + NADPH = (3R)-hydroxytriacontanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46830", "l": "4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH => 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190256", "l": "FGFR1c binds to FGF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63669", "l": "CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+) => (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34163", "l": "hydroquinone + O2 = (2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+)"}, {"i": "EC:1.13.11.66", "l": "\"Hydroquinone 1,2-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.4", "l": "\"Signal-recognition-particle GTPase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696457", "l": "BDH2 dehydrogenates 3HBA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4093342", "l": "SDC2 multimerises (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37627", "l": "(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15078", "l": "H(+) + N-[(R)-pantothenoyl]-L-cysteine => (R)-pantetheine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807008", "l": "PTPRJ dephosphorylates MET (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34732", "l": "15-methylhexadecasphing-4-enine + a fatty acyl-CoA => CoA + H(+) + N-acyl-15-methylhexadecasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19718", "l": "H(+) + L-phenylalanine => 2-phenylethylamine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983156", "l": "Polyubiquitination of substrate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52836", "l": "H(+) + indole + NADH + O2 = H2O + indoxyl + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51705", "l": "S-adenosyl-L-methionine + xanthohumol => 4-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17760", "l": "H(+) + L-methionine <=> 3-(methylsulfanyl)propanamine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111970", "l": "PKC phosphorylates GRK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202127", "l": "eNOS synthesizes NO (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34399", "l": "9-cis-beta-carotene + O2 = 9-cis-10'-apo-beta-carotenal + beta-ionone"}, {"i": "EC:1.13.11.68", "l": "\"9-cis-beta-carotene 9',10'-cleaving dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56882", "l": "a 3-oxo-Delta(5)-steroid + H(+) + NADPH => a 3beta-hydroxy-Delta(5)-steroid + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43358", "l": "cholesteryl (9Z,12Z)-octadecadienoate(out) => cholesteryl (9Z,12Z)-octadecadienoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168923", "l": "Collagen type XVIII endostatin release (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45994", "l": "(2E)-decenoyl-CoA + H2O => (3R)-3-hydroxydecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61308", "l": "(+)-(R)-germacrene A + O2 + reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047066", "l": "phospholipid-hydroperoxide glutathione peroxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047621", "l": "acylpyruvate hydrolase activity"}, {"i": "RHEA:19009", "l": "a 3-acylpyruvate + H2O = a carboxylate + H(+) + pyruvate"}, {"i": "EC:3.7.1.5", "l": "\"Acylpyruvate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5362522", "l": "ALDHs oxidise atRAL to atRA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54306", "l": "n adenosine 3',5'-bisphosphate + dermatan 4',6'-disulfate + n H(+) => n 3'-phosphoadenylyl sulfate + dermatan 4'-sulfate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062192", "l": "L-rhamnose mutarotase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33500", "l": "H(+) + prephenate => 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66149", "l": "2-phenylethylamine + acetyl-CoA => CoA + H(+) + N-(2-phenylethyl)acetamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44209", "l": "12-methyltridecanoate + ATP + CoA => 12-methyltridecanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48165", "l": "epoxypheophorbide a + H2O => H(+) + red chlorophyll catabolite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29667", "l": "H2O(in) = H2O(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61199", "l": "(E)-feruloyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] <=> CoA + H(+) + myricetin 3-O-[(6-O-[(E)-feruloyl]-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187661", "l": "Ade-Rib binds AODORA2A and NTRK1,2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43617", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) => [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17623", "l": "(3S)-citramalyl-CoA + acetate => acetyl-CoA + citramalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.112", "l": "\"Adenylate dimethylallyltransferase (ADP/ATP-dependent)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54498", "l": "diphosphate + ent-atiserene => ent-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40734", "l": "(20S)-ginsenoside Rg3 + 2 H2O <=> (20S)-protopanaxadiol + 2 D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809707", "l": "MTMR12 binds MTMR2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19541", "l": "L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH"}, {"i": "EC:1.2.1.41", "l": "\"Glutamate-5-semialdehyde dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802908", "l": "RAS mutants bind inactive RAF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990081", "l": "trimethylamine receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24290", "l": "(6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine => 5-formimidoyltetrahydrofolate + glycine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047793", "l": "cycloeucalenol cycloisomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013109", "l": "RHOC GEFs activate RHOC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50914", "l": "4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+) => 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-L-ribitol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35649", "l": "3',3'-cGAMP + 2 diphosphate => ATP + GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53490", "l": "11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+) => 11beta-hydroxyandrost-4-ene-3,17-dione + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62138", "l": "dGDP + GDP => dGMP + GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74723", "l": "Endosome acidification (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004801", "l": "transaldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853429", "l": "PHLDA1 binds AURKA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59747", "l": "(9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] <=> CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43002", "l": "(1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44929", "l": "2-oxoheptanedioate + acetyl-CoA + H2O => (R)-trihomocitrate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036193", "l": "2-hydroxy-1,4-benzoxazin-3-one monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2317314", "l": "AKT binds PDPK1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41894", "l": "(2E)-tetradecenoyl-[ACP] + H2O => (3R)-hydroxytetradecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20842", "l": "CO2 + histamine => H(+) + L-histidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33968", "l": "2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O => 3-maleylpyruvate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43070", "l": "4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase] => beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443439", "l": "c-Src binds Raf1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045156", "l": "electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50787", "l": "dodecanal + NADP(+) <=> (2E)-dodecenal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061953", "l": "mRNA (adenine-N1-)-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32344", "l": "(+)-thujan-3-ol + NAD(+) => (+)-thujan-3-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50263", "l": "11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione <=> (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40618", "l": "H2O + tridecanoylglycerol <=> 2,3-didecanoyl-sn-glycerol + decanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53493", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) => 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852362", "l": "GTSE1 binds CDKN1A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50916", "l": "a carboxylate + ATP + H(+) + NADPH = AMP + an aldehyde + diphosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691004", "l": "XPC binds RAD23 and CETN2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689544", "l": "UCHL5 binds INO80 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57677", "l": "4-epi-eremophilene + O2 + reduced [NADPH--hemoprotein reductase] => 4-epi-eremophilene-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688377", "l": "Defective pro-SFTPC does not translocate from ER membrane to multivesicle body (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21235", "l": "L-histidine <=> NH4(+) + trans-urocanate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050786", "l": "RAGE receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209910", "l": "Iodide is taken up by thyroid epithelial cells (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23836", "l": "D-methionine + pyruvate = 4-methylsulfanyl-2-oxobutanoate + L-alanine"}, {"i": "EC:2.6.1.41", "l": "\"D-methionine--pyruvate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3785684", "l": "Fibronectin degradation by CTSG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32720", "l": "L-dihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-5-(methylsulfanyl)pentanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982703", "l": "PKC binds active G alpha (z) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0004950", "l": "chemokine receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24252", "l": "H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = 2 ADP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169402", "l": "ISGylation of E2 conjugating enzymes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77068", "l": "Activation of GT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12123", "l": "alpha-D-glucose 1-phosphate + ATP + H(+) <=> ADP-alpha-D-glucose + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5681980", "l": "ATG12 binds ATG7 dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2090079", "l": "GLB1 hydrolyses linker chain(2) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48727", "l": "aurachin B + H(+) + H2O <=> 3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3341277", "l": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53505", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine => 5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0001637", "l": "G protein-coupled chemoattractant receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381309", "l": "PPARG:RXRA heterodimer binds to fatty acid-like ligands (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801666", "l": "PLK2 phosphorylates CENPJ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30367", "l": "adenosylcob(III)alamin 5'-phosphate + H2O = adenosylcob(III)alamin + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16068", "l": "2-oxoglutarate + O2 + phytanoyl-CoA <=> 2-hydroxyphytanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48914", "l": "CMP + ganglioside GT1a + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1a"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606839", "l": "Steryl sulfatase hydrolyses sulfate from steroid sulfates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21111", "l": "(S)-3-methyl-2-oxopentanoate + H(+) <=> 2-methylbutanal + CO2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052872", "l": "tocotrienol omega-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34533", "l": "CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose + H(+) => acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008817", "l": "cob(I)yrinic acid a,c-diamide adenosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12638", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose => (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296304", "l": "GPR31 is a receptor for 12(S)-HETE (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669013", "l": "EDA-3 binds EDA2R (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29479", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-epicubenol + diphosphate"}, {"i": "EC:4.2.3.64", "l": "\"(+)-epicubenol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10949", "l": "ATP + D-glucosamine => ADP + D-glucosamine 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225947", "l": "Binding of SHC1 to p-6Y-EGFR mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700662", "l": "(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47430", "l": "3-oxo-(9Z-octadecenoyl)-CoA + H(+) + NADH => (3S)-hydroxy-(9Z-octadecenoyl)-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34636", "l": "1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 => H2O + NADP(+) + pentalenolactone D"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58842", "l": "(24S)-hydroxycholesterol 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol sulfate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19548", "l": "H2O + sn-glycerol 3-phosphocholine <=> glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047689", "l": "aspartate racemase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803063", "l": "RNASEs bind bacterial LPS, PGN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022065", "l": "DSPGs are secreted (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30431", "l": "(S)-2,3-epoxysqualene = taraxerol"}, {"i": "EC:5.4.99.35", "l": "\"Taraxerol synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047798", "l": "cyclomaltodextrinase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062067", "l": "chloroplast photosystem I binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40479", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592249", "l": "NRF1, PPRC1, NRF2 bind the TFAM promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51479", "l": "a ribonucleoside 5'-triphosphate + formate + H(+) <=> a 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432054", "l": "Aquaporin-1 passively transports water out of cell (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14110", "l": "L-proline + NADP(+) => 1-pyrroline-5-carboxylate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60037", "l": "H2O + N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate => 3-hydroxy-3-methylhexanoate + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035715", "l": "chemokine (C-C motif) ligand 2 binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905060", "l": "calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21652", "l": "2-chlorobenzoate + H(+) + NADH + O2 = catechol + chloride + CO2 + NAD(+)"}, {"i": "RHEA:53736", "l": "a 2-halobenzoate + H(+) + NADH + O2 = a halide anion + catechol + CO2 + NAD(+)"}, {"i": "EC:1.14.12.13", "l": "\"2-halobenzoate 1,2-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709360", "l": "H2O2 reduces MetHb (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632652", "l": "Hh-Npp binds CDON and PTCH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638046", "l": "ACY3:Zn2+ dimer hydrolyses mercapturic acids (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034810", "l": "4,5-dihydroxybenzo(a)pyrene dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43664", "l": "ATP + hydrogencarbonate + tetracosanoyl-CoA = 2-carboxytetracosanoyl-CoA + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173771", "l": "Formation of RTC (Reverse Transcription Complex) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14145", "l": "ATP + guanidinoacetate = ADP + H(+) + phosphoguanidinoacetate"}, {"i": "EC:2.7.3.1", "l": "\"Guanidinoacetate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9709547", "l": "ESTG binds ESR2:chaperone complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140282", "l": "carbon-nitrogen ligase activity on lipid II"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-378975", "l": "Follitropin is a heterodimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58011", "l": "(20S)-ginsenoside F1 + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rg1 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32147", "l": "H2O + sepiapterin = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37198", "l": "octadecanoyl-CoA + sn-glycerol 3-phosphate <=> 1-octadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202459", "l": "Phosphorylation of Bcl10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047274", "l": "galactinol-sucrose galactosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38790", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52086", "l": "13-hydroxy-octadecanoate + H(+) + octadecanoate => 13-octadecanoyloxy-octadecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15876", "l": "[(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose <=> [(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57792", "l": "3,4-dinitrotoluene + NADH + O2 = 4-methyl-6-nitrocatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62978", "l": "(9Z,12Z,15Z)-octadecatrienoate + NH4(+) => (9Z,12Z,15Z)-octadecatrienamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30034", "l": "(S)-muconolactone <=> cis,cis-muconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6790038", "l": "Expression of HSP90B1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47473", "l": "(2E,4E)-tetradecadienoyl-CoA + H(+) + NADPH => (3E)-tetradecenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21331", "l": "cholesterol + O2 <=> cholest-4-en-3-one + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9698844", "l": "MLKL binds HSP90:CDC37 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1963589", "l": "ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047973", "l": "guanidinoacetate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9690461", "l": "FKBP1A binds tacrolimus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201515", "l": "Active ALK recruits PI3K (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15930", "l": "2 H(+) + 2 H2O + methylenediurea => CO2 + N-(hydroxymethyl)urea + 2 NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57419", "l": "H2O + L-asparaginyl-[protein] <=> L-aspartyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0016922", "l": "nuclear receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201637", "l": "Caspase-mediated cleavage of plectin-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51953", "l": "(E)-2-methylpropanal oxime + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2-methylpropanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45936", "l": "3-methylundecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(4-methyl-2-oxododecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213248", "l": "Transport of antigen loaded MHC II molecules to surface (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139917", "l": "tBID activates BAX protein (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55745", "l": "coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] => coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52353", "l": "(24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate => (24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102800", "l": "caffeoyl-CoA:pelargonidin-3,5-diglucoside-6''-O-acyltransferase activity"}, {"i": "MetaCyc:RXN-8138"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10993", "l": "glycolate + NADP(+) => glyoxylate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47717", "l": "4-pregnen-20,21-diol-3-one + NAD(+) => 21-hydroxyprogesterone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56696", "l": "D-ribulose 5-phosphate + L-tryptophan = (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate"}, {"i": "EC:4.1.99.25", "l": "\"L-tryptophan isonitrile synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212352", "l": "Formation of ARC coactivator complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39882", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol <=> a 1-acyl-sn-glycero-3-phosphoethanolamine + a 2,3-diacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140211", "l": "folic acid:proton symporter activity"}, {"i": "TCDB:2.A.1.50.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983696", "l": "The Immunoglobulin of the BCR binds antigen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19025", "l": "H2O + L-aspartate + O2 = H2O2 + NH4(+) + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61929", "l": "(R)-miconazole(in) + ATP + H2O => (R)-miconazole(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191299", "l": "Squalene is oxidized to its epoxide (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44457", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine => a 1-acyl-sn-glycero-3-phosphocholine + a 1-O-acyl-N-acylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12530", "l": "[hyaluronan](n+1) + H(+) + UDP => N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44819", "l": "1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-12 + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29775", "l": "alpha-D-ribose 1-phosphate + ATP = ADP + alpha-D-ribose 1,5-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66405", "l": "ATP + glutathione(in) + H2O + taurocholate(in) => ADP + glutathione(out) + H(+) + phosphate + taurocholate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419861", "l": "Melanospin is stimulated by light (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56703", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 <=> 3-[(Z)-2-isocyanoethenyl]-1H-indole + 2 CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047650", "l": "alkylglycerone kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58079", "l": "1-(11Z-eicosenoyl)-glycerol + H2O <=> (11Z)-eicosenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781905", "l": "ZRANB1 binds APC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29898", "l": "ATP + H2O + L-glutamine(out) <=> ADP + H(+) + L-glutamine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58931", "l": "(3R,4R)-7,2',4'-trihydroxyisoflavanol <=> (6aR,11aR)-3,9-dihydroxypterocarpan + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015439", "l": "ABC-type heme transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54756", "l": "deamido-NAD(+) + hydrogencarbonate = AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide"}, {"i": "EC:2.5.1.143", "l": "\"Pyridinium-3,5-biscarboxylic acid mononucleotide synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980051", "l": "DLL4 binds NOTCH2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013438", "l": "RHOD binds effectors at the endosome membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6805061", "l": "CK2 binds FACT (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20916", "l": "L-cysteine + sulfite = hydrogen sulfide + L-cysteate"}, {"i": "EC:4.4.1.10", "l": "\"Cysteine lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21388", "l": "H2O + L-2-aminohexano-6-lactam = L-lysine"}, {"i": "EC:3.5.2.11", "l": "\"L-lysine-lactamase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32499", "l": "(1R,5R)-sabinene + H(+) + NADPH + O2 = (1S,3R,5S)-sabinol + H2O + NADP(+)"}, {"i": "EC:1.14.13.153", "l": "\"(+)-sabinene 3-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031512", "l": "Expression of APOE regulated by NR1H2 or NR1H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37888", "l": "S-adenosyl-L-methionine + small RNA 3'-end nucleotide => H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13743", "l": "indole-3-pyruvate + L-phenylalanine => 3-phenylpyruvate + L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669012", "l": "EDA binds EDAR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57872", "l": "(E)-2,4-dihydroxycinnamoyl-CoA = CoA + umbelliferone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66100", "l": "3-(4-hydroxyphenyl)pyruvate + L-kynurenine = H2O + kynurenate + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54447", "l": "a (2R,3S,4S)-leucoanthocyanidin + NADP(+) <=> a (2R,3R)-dihydroflavonol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52582", "l": "ADP + H(+) + Pb(2+)(out) + phosphate => ATP + H2O + Pb(2+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52563", "l": "2-dehydro-D-erythronate <=> 3-dehydro-D-erythronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16826", "l": "ATP + uridine => ADP + H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800042", "l": "TP53 binds the IGFBP3 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983259", "l": "Kinesins move along microtubules consuming ATP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34403", "l": "9-cis-10'-apo-beta-carotenal + 2 O2 = (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal + carlactone"}, {"i": "EC:1.13.11.69", "l": "\"Carlactone synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45653", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29056", "l": "a ubiquinone + 2 H(+)(in) + H2 => a ubiquinol + 2 H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34650", "l": "S-adenosyl-L-methionine + squalene <=> 3-methyl-1,2-didehydro-2,3-dihydrosqualene + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21179", "l": "L-idonate + NADP(+) <=> 5-dehydro-D-gluconate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008271", "l": "CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3134914", "l": "Beta-catenin migrates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22753", "l": "A + H2O + uracil => AH2 + barbiturate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49653", "l": "H(+) + NADH + O2 + protoviolaceinate => H2O + NAD(+) + violaceinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047880", "l": "erythrulose reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168285", "l": "Clathrin-Mediated Pit Formation And Endocytosis Of The Influenza Virion (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372855", "l": "malate + NAD+ <=> oxaloacetate + NADH + H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24545", "l": "H2O + L-lysyl-[protein] + O2 => (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41691", "l": "1-O-hexadecyl-2-propanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38602", "l": "NADP(+) + nicotinate <=> nicotinamide + nicotinate-adenine dinucleotide phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59131", "l": "(S)-2,3-diaminopropanoate + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + ATP <=> 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14232", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008331", "l": "high voltage-gated calcium channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12370", "l": "2,5-didehydro-D-gluconate + AH2 => 2-dehydro-D-gluconate + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187575", "l": "Ubiquitination of phospho-p27/p21 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632674", "l": "ADRBK1 binds phosphorylated SMO dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "76.711710297129045", "identifiers": [{"i": "GO:0019887", "l": "protein kinase regulator activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031773", "l": "kisspeptin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45621", "l": "H2O + N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-butanoyl ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.2.-", "l": "\"With dinitrogen as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196026", "l": "Dab2 is recruited to the junctional plaques (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20304", "l": "ATP + L-arginine + tRNA(Arg) <=> AMP + diphosphate + L-arginyl-tRNA(Arg)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44067", "l": "hexadecanoyl-CoA + octan-1-ol <=> CoA + octyl hexadecanoyl"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686335", "l": "CSF2RA:CSF2RB binds SFTPs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-418456", "l": "cGMP is degraded by PDEs (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52795", "l": "chlorophyllide a + 2 H(+) <=> Mg(2+) + pheophorbide a"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18399", "l": "AMP + diphosphate + L-glutamyl-tRNA(Glx) => ATP + L-glutamate + tRNA(Glx)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388814", "l": "Grb2 binds CD28 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853745", "l": "RET binds GFRA1,GFRA3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353481", "l": "5-methylcytosine G/T mismatch specific DNA glycosylase mediated recognition and binding of thymine opposite guanine at CpG sequences (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047878", "l": "erythritol kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26292", "l": "2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine <=> 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35323", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605632", "l": "Both hexosaminidase A and B can cleave GalNAc from globoside (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64442", "l": "glycylglycyl-L-proline(in) + H(+)(in) => glycylglycyl-L-proline(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65374", "l": "CMP + globoside MSGG + H(+) => CMP-N-acetyl-beta-neuraminate + globoside GalGb4Cer"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51891", "l": "2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+) <=> 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21914", "l": "acetyl-CoA + CO2 + H2O2 => CoA + H(+) + O2 + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30326", "l": "all-trans-beta-carotene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008490", "l": "arsenite secondary active transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19762", "l": "FMN-N(5)-oxide + H(+) + NADH => FMN + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57478", "l": "2-hydroxydodecanoate + H2O => dodecanoate + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034852", "l": "4,4-dimethyl-3-oxopentanal dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12501", "l": "NADP(+) + thiomorpholine-3-carboxylate => 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32114", "l": "S-adenosyl-L-methionine + trans-resveratrol <=> 3-methoxy-4',5-dihydroxy-trans-stilbene + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2394007", "l": "PI3K gain of function mutants phosphorylate PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668481", "l": "Protesomal degradation of K48polyUb-TRAF3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28975", "l": "H(+)(out) + L-asparagine(in) = H(+)(in) + L-asparagine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014433", "l": "RHOG GEFs activate RHOG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551555", "l": "RYK binds WNT5A and VANGL2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48253", "l": "ganglioside GD2 + UDP-alpha-D-galactose => ganglioside GD1b + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214853", "l": "WEK and MYD88:TUB bind to the TL receptor (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20458", "l": "D-arabinose + NAD(+) => D-arabinono-1,4-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63896", "l": "aspulvinone E + hnu = isoaspulvinone E"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668545", "l": "NIK autophosphorylates on T559 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848864", "l": "PTK6 binds ARAP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034846", "l": "naphthyl-2-methylene-succinyl-CoA lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25457", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + gamma-humulene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61943", "l": "3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + UDP-alpha-D-glucose <=> 3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848804", "l": "HIF1A,EPAS1 promote PTK6 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47607", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) <=> CMP + ganglioside GP1calpha (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990458", "l": "lipooligosaccharide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19833", "l": "(6S)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)"}, {"i": "EC:3.5.1.10", "l": "\"Formyltetrahydrofolate deformylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21450", "l": "16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate => 16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65770", "l": "a 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1,1-dimethyl-3-phenylurea + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218847", "l": "PAK2 binds NCK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0019118", "l": "phenanthrene-epoxide hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72647", "l": "Cap-bound mRNA is activated by helicases  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41749", "l": "3'-phosphoadenylyl sulfate + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol => 1,2-diacyl-3-(3-O-sulfo-beta-D-galactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0106346", "l": "snRNA methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32108", "l": "3-methoxy-4',5-dihydroxy-trans-stilbene + S-adenosyl-L-methionine => H(+) + pterostilbene + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372977", "l": "succinylCoA + ADP + Pi <=> succinate + CoASH + ATP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684032", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12929", "l": "2-oxoglutarate + acetyl-CoA + H2O = (2R)-homocitrate + CoA + H(+)"}, {"i": "EC:2.3.3.14", "l": "\"Homocitrate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168376", "l": "STIM1 oligomerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51579", "l": "phloretin + UDP-alpha-D-glucose <=> H(+) + phlorizin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61450", "l": "11a-hydroxytigecycline + H2O + NADP(+) => H(+) + NADPH + O2 + tigecycline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9671145", "l": "DKC1 binds SHQ1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102722", "l": "gamma-hydroxybutyrate dehydrogenase activity (NAD(P)-dependent"}, {"i": "MetaCyc:RXN-6903"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678998", "l": "Endosomal TLRs pass through the Golgi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47904", "l": "ATP + N-(acetyl)-sphing-4-enine = ADP + H(+) + N-(acetyl)-sphing-4-enine-1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52681", "l": "acetyl-CoA + L-alpha-phenylglycine => CoA + H(+) + N-acetyl-L-alpha-phenylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953013", "l": "E2F7 binds E2F8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40342", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP <=> 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18055", "l": "4-nitrophenol + diethylphosphate + 2 H(+) => H2O + paraoxon"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50683", "l": "H2O + N-terminal L-glutaminyl-[protein] <=> N-terminal L-glutamyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10089", "l": "sucrose + UDP-alpha-D-galactose => 6(F)-alpha-D-galactosylsucrose + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61492", "l": "a sphingoid base + an ultra-long-chain fatty acyl-CoA = an N-(ultra-long-chain-acyl)-sphingoid base + CoA + H(+)"}, {"i": "EC:2.3.1.298", "l": "\"Ultra-long-chain ceramide synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174367", "l": "GCL ligates L-Glu to L-Cys (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164510", "l": "Conformational change in gp120 of Env oligomer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18968", "l": "hydroxymethylbilane <=> H2O + uroporphyrinogen III"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33754", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.40", "l": "\"Anthraniloyl-CoA monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202510", "l": "Activation of TAK1-TAB2 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38890", "l": "H2O + N-hexanoyl-sphinganine <=> hexanoate + sphinganine"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0018488", "l": "aryl-aldehyde oxidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990447", "l": "U2 snRNP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12358", "l": "D-fructose 6-phosphate => D-mannose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63985", "l": "5-hydroxyuridine + ATP => 5-hydroxyuridine 5'-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39689", "l": "(2E,11Z)-octadecadienoyl-CoA + H2O => (R)-3-hydroxy-(11Z)-octadecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33432", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate => (3E)-2-oxohex-3-enedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917700", "l": "MVB Vesicle Formation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432436", "l": "CLK:CYC heterodimer binds to per, tim, vri, and Pdp1 genes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35181", "l": "7 CO2 + 7 CoA + 2 H2O + holo-[ACP] + noranthrone => 6 H(+) + hexanoyl-[ACP] + 7 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-453339", "l": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36160", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 oxidized 2[4Fe-4S]-[ferredoxin] => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1031713", "l": "GAF binds the GAS promoter elements in the IFNG-regulated genes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551648", "l": "SUMOylation of TDG with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54210", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O => 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21978", "l": "[thioredoxin]-dithiol + adenosine 5'-phosphosulfate => [thioredoxin]-disulfide + AMP + 2 H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64055", "l": "(13Z)-docosenoyl-CoA + (4R)-hydroxysphinganine <=> CoA + H(+) + N-(13Z-docosenoyl)-4R-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "ic": "69.63974591466652", "identifiers": [{"i": "GO:0071855", "l": "neuropeptide receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46086", "l": "glycerol + phosphate => H2O + sn-glycerol 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32196", "l": "abieta-7,13-dien-18,18-diol => abieta-7,13-dien-18-al + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1006169", "l": "Factor H binds host cell surface markers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31873", "l": "alpha-seco-amyrin => (S)-2,3-epoxysqualene"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102074", "l": "OPC6-trans-2-enoyl-CoA hydratase activity"}, {"i": "MetaCyc:RXN-10704"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984964", "l": "IL12A gene transcription and translation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693111", "l": "RHOF auto-activates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21431", "l": "(R)-3-sulfolactate <=> H(+) + pyruvate + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201639", "l": "Caspase-mediated cleavage of GAS2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000171", "l": "ribonuclease MRP activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700171", "l": "Active ALK phosphorylates PLCG1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168888", "l": "Alpha1-Microglobulin binds heme (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23005", "l": "a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine => a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088281", "l": "Endorepellin binds KDR (VEGFR2) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061483", "l": "sulfinylpropanyl adenylate synthase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52671", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate <=> [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004513", "l": "neolactotetraosylceramide alpha-2,3-sialyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0101006", "l": "protein histidine phosphatase activity"}, {"i": "RHEA:47960", "l": "H2O + N(tele)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + phosphate"}, {"i": "RHEA:47964", "l": "H2O + N(pros)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + phosphate"}, {"i": "EC:3.9.1.3", "l": "\"Phosphohistidine phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.20", "l": "\"Chondroitin-sulfate-ABC endolyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937807", "l": "SRC phosphorylates RUNX3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36713", "l": "ADP + CO2 + D-cycloserine + NH4(+) + phosphate => ATP + H(+) + H2O + O-ureido-D-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24808", "l": "(2S)-2-acetolactate + thiamine diphosphate <=> 2-(1-hydroxyethyl)thiamine diphosphate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47836", "l": "[5-(aminomethyl)-3-furyl]methyl phosphate + ATP = [5-(aminomethyl)furan-3-yl]methyl diphosphate + ADP"}, {"i": "EC:2.7.4.31", "l": "\"(5-(aminomethyl)furan-3-yl)methyl phosphate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62545", "l": "2 [Fe(II)cytochrome c] + 3 H(+) + ouabagenin => 2 [Fe(III)cytochrome c] + dihydroouabagenin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60377", "l": "D-glucose(out) => D-glucose(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.50"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18867", "l": "(R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[protein] + CoA => (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2-methylpropanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16677", "l": "fluoroacetaldehyde + H2O + NAD(+) = fluoroacetate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.69", "l": "\"Fluoroacetaldehyde dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61614", "l": "7-epi-cylindrospermopsin + CO2 + succinate => 2-oxoglutarate + 7-deoxycylindrospermopsin + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14385", "l": "dolichyl diphosphate + H2O = dolichyl phosphate + H(+) + phosphate"}, {"i": "EC:3.6.1.43", "l": "\"Dolichyldiphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10931", "l": "ent-kaur-16-en-19-al + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-kaur-16-en-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196929", "l": "FLAD1 phosphorylates FMN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847880", "l": "CYTH proteins bind ARF1:GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981497", "l": "ST3GAL1-4 can add a sialic acid to the T antigen at the alpha 3 position (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66445", "l": "hexan-3-one + NADP(+) => (E)-4-hexen-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27280", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH => 2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16846", "l": "acetyl-CoA + H2O + oxaloacetate => citrate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008840", "l": "4-hydroxy-tetrahydrodipicolinate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41804", "l": "3-oxobutanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxybutanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112396", "l": "Separation of elongating transcript from template (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3318415", "l": "ATF2 acetylates histone H2B, H4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.111", "l": "\"Phosphatidylserine sn-1 acylhydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19199", "l": "adenosine 5'-phosphoramidate + 2 H(+) + sulfate => adenosine 5'-phosphosulfate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985594", "l": "MYO9B inactivates RHOA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25032", "l": "ADP-D-ribose 1''-phosphate + H2O <=> ADP-D-ribose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17498", "l": "formononetin + UDP-alpha-D-glucose => ononin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62044", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphoglycerol + H2O = (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphoglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655834", "l": "SREBP1A,1C,2:SCAP translocates to the Golgi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005352", "l": "alpha-glucoside:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37366", "l": "5 AH2 + 2 H(+) + heme b + 4 O2 <=> 5 A + beta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047415", "l": "D-benzoylarginine-4-nitroanilide amidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66148", "l": "2-phenylethylamine + acetyl-CoA = CoA + H(+) + N-(2-phenylethyl)acetamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21581", "l": "(2S)-2-acetolactate + H(+) => (R)-acetoin + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213248", "l": "Transport of antigen loaded MHC II molecules to surface (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35188", "l": "(Z)-3-aminoperacrylic acid + AH2 => (Z)-3-aminoacrylate + A + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64907", "l": "GTP + 2 H2O <=> GMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23958", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP => L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805640", "l": "AKT phosphorylates KAT6A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114552", "l": "Thrombin-activated PARs activate G12/13 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947535", "l": "Cyclisation of GTP to precursor Z (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798749", "l": "Exocytosis of specific granule lumen proteins (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43071", "l": "beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987039", "l": "JAK1 binds IL20RA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2317314", "l": "AKT binds PDPK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112379", "l": "Recruitment of elongation factors to form elongation complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672951", "l": "Inactive RAFs bind YWHAB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551683", "l": "SUMOylation of TOPORS with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666001", "l": "Profilin:G-actin binds MKL1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36064", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + kunzeaol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008897", "l": "holo-[acyl-carrier-protein] synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21931", "l": "3-dehydro-L-gulonate + NADP(+) <=> 2,3-dioxo-L-gulonate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47991", "l": "2-dehydro-3-deoxy-L-galactonate + NAD(+) <=> 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867344", "l": "OMA1 hydrolyses OPA1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694442", "l": "CNIH2,3 bind GRIA1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39437", "l": "(3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+) => (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043734", "l": "DNA-N1-methyladenine dioxygenase activity"}, {"i": "REACT:R-HSA-112118", "l": "Oxidative demethylation of 1-meA damaged DNA by ALKBH2 (Homo sapiens)"}, {"i": "REACT:R-HSA-112123", "l": "Oxidative demethylation of 1-meA damaged DNA By ALKBH3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65161", "l": "benzoyl-CoA + hexan-2-ol => CoA + hexan-2-yl benzoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60371", "l": "urate(out) <=> urate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32626", "l": "L-threo-tetrahydrobiopterin + 2 NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56097", "l": "[protein]-C-terminal Gly-Gly + ATP + H(+) => [protein]-C-terminal Gly-Gly-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043751", "l": "polyphosphate:AMP phosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419861", "l": "Melanospin is stimulated by light (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37781", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047275", "l": "glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity"}, {"i": "MetaCyc:2.4.1.86-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43026", "l": "2-aminoprop-2-enoate + a thiol => an S-substituted L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20664", "l": "D-alanyl-D-alanine + H2O <=> 2 D-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3662344", "l": "Defective HEXB does not cleave the terminal GalNAc from DS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62469", "l": "3,4-dihydroxybenzoate + ATP + H(+) => 3,4-dihydroxybenzoyl-5'-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56975", "l": "(R)-3-hydroxy-2-methylpropanoate + NAD(+) <=> (R)-methylmalonate semialdehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102998", "l": "4-sulfomuconolactone hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36451", "l": "ATP + glycyl-L-glutamate(out) + H2O = ADP + glycyl-L-glutamate(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61723", "l": "a D-guloside + NAD(+) <=> a 3-dehydro-D-guloside + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210277", "l": "Interaction of PECAM-1 and SHP-1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002039", "l": "p53 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67116", "l": "N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.3.-", "l": "\"Cyclo-ligases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.65", "l": "\"Levanase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22275", "l": "(20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase] <=> (20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63953", "l": "a sphingoid 1-phosphate + H2O => a sphingoid base + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27646", "l": "inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381466", "l": "Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2562541", "l": "TLR4-induced ripoptosome assembly (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34304", "l": "L-lysine => L-pipecolate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.24.-", "l": "\"Site specific endodeoxyribonucleases: cleavage is not sequence specific\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193641", "l": "IKK-beta is recruited (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.24", "l": "\"Alpha-mannosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046507", "l": "UDPsulfoquinovose synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804402", "l": "TP53 binds POU4F1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42950", "l": "5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(48) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64807", "l": "acetyl-CoA + S-(2-aminoethyl)-L-cysteine <=> CoA + H(+) + S-(2-acetamidoethyl)-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20039", "l": "aldehydo-D-glucose 6-phosphate + H(+) + NADPH => D-sorbitol 6-phosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47772", "l": "a guanosine in 21S rRNA + S-adenosyl-L-methionine = a 2'-O-methylguanosine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799350", "l": "Exocytosis of specific granule membrane proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17524", "l": "ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) <=> ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40344", "l": "3-oxohexadecanedioyl-CoA + CoA => acetyl-CoA + tetradecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.337", "l": "\"L-2-hydroxycarboxylate dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2172678", "l": "PHF8 demethylates histone H4K20me1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60777", "l": "2-oxoglutarate + gibberellin A12 + O2 => CO2 + gibberellin A15 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26284", "l": "Co-precorrin-5A + H2O <=> acetaldehyde + Co-precorrin-5B + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44650", "l": "a 2-acyl-sn-glycerol 3-phosphate + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63551", "l": "angiotensin-(1-9) + H2O <=> angiotensin-(1-7) + L-phenylalanyl-L-histidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086060", "l": "voltage-gated sodium channel activity involved in AV node cell action potential"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46016", "l": "(20R)-20-hydroxypregn-4-en-3-one + NAD(+) = H(+) + NADH + progesterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421197", "l": "adenylosuccinate => adenosine 5'-monophosphate (AMP) + fumarate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932327", "l": "NFE2L2 binds KEAP1:CUL3:RBX1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61132", "l": "(2R,3R)-dihydrokaempferol + 2-oxoglutarate + O2 = CO2 + H(+) + H2O + kaempferol + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-500708", "l": "GRIK3 homomer binds glutamate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39377", "l": "(2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62403", "l": "(1R,2S)-ephedrine + NAD(+) <=> (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437118", "l": "GPVI stimulates PI3K beta, gamma (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102856", "l": "1-18:2-2-18:2-sn-glycerol-3-phosphocholine desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428231", "l": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54648", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + H2O"}, {"i": "EC:4.2.1.173", "l": "\"Ent-8-alpha-hydroxylabd-13-en-15-yl diphosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788628", "l": "p-Y-STATs dissociate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64595", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46510", "l": "catechol + NAD(+) + nitrite => NADH + nitrobenzene + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36983", "l": "(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014293", "l": "RAC2 GDIs block activation of RAC2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-606326", "l": "HJURP:CENPA complex localizes to the centromere (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15127", "l": "CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n) => acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23318", "l": "2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil => 2'-deoxyuridine + 2-oxoglutarate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38484", "l": "a 2,3-diacyl-sn-glycerol + H2O => a 2-acylglycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33489", "l": "CoA + H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + 2-hydroxyhexacosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43230", "l": "H(+) + N(5)-methyl-L-glutamine(104)-[histone H2A] + S-adenosyl-L-homocysteine => L-glutamine(104)-[histone H2A] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140769", "l": "factor VII -> factor VIIa (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67015", "l": "a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.98.-", "l": "\"With other, known, acceptors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62303", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + H(+) + NADPH <=> 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109858", "l": "MAP2K2 binds MAPK1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35694", "l": "(2S)-versicolorone + NADP(+) <=> 1'-hydroxyversicolorone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678694", "l": "Heparanase 2 (HPSE2) cleaves heparan sulfate from its proteoglycan (plasma membrane) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660819", "l": "ADORA2B:Ade-Rib:GsGTP dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58118", "l": "3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP => L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866277", "l": "AP-2 directly binds some endocytic cargo (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8871226", "l": "RET binds GFRA1,GFRA2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848087", "l": "STAP2 recruits STAT3 to PTK6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17326", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA => (S)-2-succinylamino-6-oxoheptanedioate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932327", "l": "NFE2L2 binds KEAP1:CUL3:RBX1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635839", "l": "ULK3:SUFU dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0030226", "l": "apolipoprotein receptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047710", "l": "bis(5'-adenosyl)-triphosphatase activity"}, {"i": "MetaCyc:BIS5-ADENOSYL-TRIPHOSPHATASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-874087", "l": "SGT1 binds HSP90 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29325", "l": "fumarate(out) + succinate(in) => fumarate(in) + succinate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64982", "l": "20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18291", "l": "H2O + oxaloacetate => (S,S)-tartrate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050256", "l": "ribitol-5-phosphate 2-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48535", "l": "ganglioside GQ1c (d18:1(4E)) + H2O <=> ganglioside GT1c (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20118", "l": "ATP + L-rhamnulose => ADP + H(+) + L-rhamnulose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209365", "l": "Phosphorylated STAT92E dimer transports from the cytosol to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1977959", "l": "ERBB4 forms heterodimers with EGFR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399930", "l": "Activation of PAK by Rac1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43053", "l": "3-(methylsulfanyl)propanoate + ATP + CoA => 3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37582", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948230", "l": "P3HB binds 4-Hyp-collagen propeptides (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35164", "l": "H(+)(out) + minocycline(in) => H(+)(in) + minocycline(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229283", "l": "LCNs bind lipids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684008", "l": "NBN binds KPNA2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33060", "l": "(R)-dihydrolipoamide + NAD(+) => (R)-lipoamide + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418856", "l": "Activation of Rac1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61842", "l": "brassicasterol 3-beta-D-glucoside + H(+) + UDP => brassicasterol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804955", "l": "ATM phosphorylates MDM2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22158", "l": "GMP + H(+) + phosphate => GDP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912413", "l": "NOTCH2 mRNA translation controlled by miRNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848414", "l": "Activated PTK6 binds CDKN1B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13402", "l": "(2E,6E)-farnesol => (2Z,6E)-farnesol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2514831", "l": "Fibrillin-1 degradation by MMP14 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665998", "l": "MKL1 binds SRF (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13333", "l": "beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 2-phosphate + phosphate"}, {"i": "EC:3.1.3.54", "l": "\"Fructose-2,6-bisphosphate 6-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047991", "l": "hydroxylamine oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432164", "l": "Ca2+ influx into the post-synaptic cell (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018633", "l": "dimethyl sulfide monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18368", "l": "(R)-malate + NAD(+) <=> CO2 + NADH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350578", "l": "NQO1 interaction with ODC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952069", "l": "HDAC4 deacetylates RUNX3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51325", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => (8R)-hydroperoxy-(9E,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27589", "l": "L-tryptophan + pyruvate <=> indole-3-pyruvate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186778", "l": "SHP2 binds to the active receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29656", "l": "L-cysteine(in) => L-cysteine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43642", "l": "3-oxotetradecanoyl-[ACP] + CO2 + CoA => dodecanoyl-CoA + H(+) + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093327", "l": "EPHA binds TIAM1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34641", "l": "H2O + NADP(+) + neopentalenolactone D => 1-deoxy-11-oxopentalenate + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706364", "l": "Internalization of ubiquitinated FLT3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17093", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol"}, {"i": "EC:4.6.1.13", "l": "\"Phosphatidylinositol diacylglycerol-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624956", "l": "PDE6D binds INPP5E (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43709", "l": "ATP + H(+) + hexadecanoate => diphosphate + hexadecanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0061133", "l": "endopeptidase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56613", "l": "L-cysteinyl-[protein] + NAD(+) => H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28647", "l": "acetophenone + 2 ATP + H2O + hydrogencarbonate = 3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate"}, {"i": "EC:6.4.1.8", "l": "\"Acetophenone carboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5691131", "l": "CANDI binds CUL1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13245", "l": "D-threo-isocitrate = glyoxylate + succinate"}, {"i": "EC:4.1.3.1", "l": "\"Isocitrate lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156908", "l": "eEF1A:GTP:aminoacyl tRNA ternary complex formation. (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44424", "l": "a fatty acyl-CoA + heptadecasphing-4-enine = CoA + H(+) + N-acyl-heptadecasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647980", "l": "mature RAS proteins translocate to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50511", "l": "acetyl-CoA + N-terminal L-valyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28925", "l": "H(+)(out) + L-phenylalanine(out) => H(+)(in) + L-phenylalanine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13153", "l": "(R)-glycerate + CO2 + NAD(+) = 2-hydroxy-3-oxosuccinate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57791", "l": "1,3-dinitrobenzene + NADH + O2 <=> 4-nitrocatechol + H(+) + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15245", "l": "a monoacylglycerol + H2O = a fatty acid + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15288", "l": "AMP + dimethylallyl diphosphate <=> diphosphate + N(6)-(dimethylallyl)adenosine 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40917", "l": "(9Z)-octadecenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) => 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12540", "l": "ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)"}, {"i": "EC:6.1.1.7", "l": "\"Alanine--tRNA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-560510", "l": "Expression of FABP4 (aP2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40932", "l": "2-oxoglutarate + L-ornithine + O2 => (3S)-3-hydroxy-L-ornithine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52460", "l": "17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932334", "l": "KEAP1:CUL3:RBX1:NFE2L2 dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63038", "l": "NH4(+) + octadecanoate => H2O + octadecanamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51969", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 => (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200396", "l": "Creatine transport across the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31313", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + ADP + H(+) => (2R)-3-phosphoglycerate + ADP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58024", "l": "oleanolate + UDP-alpha-D-glucose = H(+) + oleanolate 3-O-beta-D-glucoside + UDP"}, {"i": "EC:2.4.1.368", "l": "\"Oleanolate 3-O-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102865", "l": "delta6-acyl-lipid desaturase activity"}, {"i": "RHEA:46536", "l": "(6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-containing glycerolipid + 2 H2O"}, {"i": "RHEA:46540", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-containing glycerolipid + 2 H2O"}, {"i": "EC:1.14.19.38", "l": "\"Acyl-lipid Delta(6)-acetylenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35746", "l": "H(+) + NADPH + O2 + versicolorin B <=> 2 H2O + NADP(+) + versicolorin A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13024", "l": "4-hydroxy-3-methoxybenzoate + H(+) + NADH + O2 <=> 3,4-dihydroxybenzoate + formaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879459", "l": "F-actin capping protein is a heterodimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47941", "l": "ganglioside GM2 (d18:1(4E)) + H2O => ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19190", "l": "[dihydrolipoyllysine-residue acetyltransferase]-(R)-N(6)-lipoyl-L-lysine + H(+) + pyruvate => [dihydrolipoyllysine-residue acetyltransferase]-(R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13419", "l": "H(+) + NADH + xanthommatin => 5,12-dihydroxanthommatin + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45228", "l": "a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48258", "l": "(2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein] => (2S)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018504", "l": "cis-1,2-dihydrobenzene-1,2-diol dehydrogenase activity"}, {"i": "RHEA:15457", "l": "cis-1,2-dihydrobenzene-1,2-diol + NAD(+) = catechol + H(+) + NADH"}, {"i": "RHEA:25193", "l": "(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) = 3-methylcatechol + H(+) + NADH"}, {"i": "EC:1.3.1.19", "l": "\"Cis-1,2-dihydrobenzene-1,2-diol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019973", "l": "interleukin-13 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507719", "l": "p62:MEKK3 binds to TRAF6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46800", "l": "H(+) + Na(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = Na(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:7.2.1.2", "l": "\"Ferredoxin--NAD(+) oxidoreductase (Na(+)-transporting)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55906", "l": "6,7-dichloro-L-tryptophan + FAD + 2 H2O => 7-chloro-L-tryptophan + chloride + FADH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29810", "l": "ATP + H2O + L-leucine(out) <=> ADP + H(+) + L-leucine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50104", "l": "taurine + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoyl-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42065", "l": "ATP + GTP => 2',3'-cGAMP + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018489", "l": "vanillate monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5655170", "l": "RCHY1 monoubiquitinates POLH (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3321883", "l": "MSL acetylates histone H4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672951", "l": "Inactive RAFs bind YWHAB (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-990489", "l": "Kinesin-13 is a dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43178", "l": "5-methylcytidine(2870) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(2870) in 25S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23358", "l": "ADP + H(+) + O-phospho-L-seryl-[rhodopsin] => ATP + L-seryl-[rhodopsin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21353", "l": "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 => (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40489", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.20", "l": "\"Aminopeptidase Ey\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51019", "l": "7,8-dihydroneopterin 3'-phosphate <=> 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047057", "l": "vitamin-K-epoxide reductase (warfarin-sensitive) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20098", "l": "D-mannonate => 2-dehydro-3-deoxy-D-gluconate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043398", "l": "HLH domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52906", "l": "ADP + coenzyme F430 + phosphate => 15,17(3)-seco-F430-17(3)-acid + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13542", "l": "H2O + tetrathionate => H(+) + sulfate + sulfur + thiosulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29275", "l": "L-isoleucine(in) + Na(+)(in) = L-isoleucine(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371435", "l": "Constitutive phosphorylation by GSK3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1362416", "l": "Frataxin binds iron (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29983", "l": "cytidine(in) + H(+)(in) = cytidine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46908", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA = 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + a 1,2-diacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51971", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 <=> (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52095", "l": "5-(9Z-hexadecenoyloxy)-octadecanoate + H2O <=> (9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24271", "l": "2,6-dioxo-6-phenylhexanoate + NADP(+) <=> 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58471", "l": "2 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51651", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] + O2 <=> (S)-2-amino-6-oxohexanoyl-[protein] + acetamide + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0052919", "l": "aliphatic (R)-hydroxynitrile lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30462", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol <=> (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + acetone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10749", "l": "H(+) + hydrogencarbonate => CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59814", "l": "CoA + H(+) + N-terminal N(6)-hexadecanoylglycyl-[protein] => hexadecanoyl-CoA + N-terminal glycyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482629", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164832", "l": "ATPase synthesizes ATP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63436", "l": "1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + a di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449087", "l": "CD4 binds Interleukin-16 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33391", "l": "C20 sphinganine 1-phosphate + H2O = C20 sphinganine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36575", "l": "(9Z)-octadecenoyl-CoA + sphinganine = CoA + H(+) + N-(9Z-octadecenoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36240", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O => 1-O-alkyl-2-acyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53388", "l": "5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + UDP-alpha-D-glucuronate = 5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008480", "l": "GSK3B phosphorylates RUNX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54523", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> cycloaraneosene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50280", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (5S)-hydroperoxy-(14R,15S)-epoxy-(6E,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982637", "l": "Opsins binds G alpha-t (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004125", "l": "L-seryl-tRNASec selenium transferase activity"}, {"i": "RHEA:22728", "l": "H(+) + L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + phosphate"}, {"i": "EC:2.9.1.1", "l": "\"L-seryl-tRNA(Sec) selenium transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36346", "l": "2-methylsulfanyl-N(6)-(Delta(2)-isopentenyl)adenosine in tRNA + H(+) + NADPH + O2 <=> 2-methylsulfanyl-N(6)-(cis-4-hydroxy-Delta(2)-isopentenyl)adenosine in tRNA + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187828", "l": "Translocation of p21 to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56752", "l": "a 14alpha-methyl steroid + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = a Delta(14) steroid + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.15.36", "l": "\"Sterol 14-alpha-demethylase (ferredoxin)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43372", "l": "an N-acylsphing-4-enine + dTDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49500", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O = GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56488", "l": "O2 + oleanolate + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hederagenin + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198756", "l": "ERK1/2 phosphorylates MSK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23293", "l": "ATP + L-lombricine => ADP + H(+) + N-phospho-L-lombricine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072373", "l": "alpha-carotene epsilon hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12976", "l": "AMP + ATP <=> 2 ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-197958", "l": "FPGS-2 transforms THF to THFPG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38763", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373716", "l": "DCC interacting NCK-1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57774", "l": "4-methylcatechol + NAD(+) + nitrite => 3-nitrotoluene + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56170", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44407", "l": "3-demethylubiquinol-7 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674385", "l": "p-T,Y MAPKs dimerize (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35416", "l": "an anthocyanidin 3-O-beta-D-sambubioside + UDP-alpha-D-glucose => an anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45563", "l": "L-isoleucine <=> D-allo-isoleucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32399", "l": "(1S,2R,4S)-neodihydrocarveol + NAD(+) = (1S,4S)-dihydrocarvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18554", "l": "(2R,3S)-tartrate + NAD(+) => dihydroxyfumarate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52430", "l": "12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoate + NAD(+) => 12-oxo-leukotriene B4 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805811", "l": "Release of SEPT4 from mitochondria (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55154", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 reduced [electron-transfer flavoprotein] => H(+) + L-prolyl-[peptidyl-carrier protein] + 2 oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17143", "l": "glyoxylate + L-aspartate => glycine + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55975", "l": "acetyl-CoA + ethanol <=> CoA + ethyl acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.32", "l": "\"Palmitoyl-CoA 14-(E/Z)-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12937", "l": "a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA"}, {"i": "EC:2.3.1.23", "l": "\"1-acylglycerophosphocholine O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30168", "l": "D-erythrose 4-phosphate + dihydroxyacetone phosphate => sedoheptulose 1,7-bisphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45512", "l": "[C-phycocyanin beta-subunit]-Cys(155)-phycocyanobilin = (2R,3E)-phycocyanobilin + apo-[C-phycocyanin beta-subunit]-Cys(155)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26333", "l": "2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O = 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin"}, {"i": "EC:2.8.1.12", "l": "\"Molybdopterin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60321", "l": "N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61578", "l": "(3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA + H(+) + NADPH => (4R,5R)-4,5-dihydroxycyclohex-2-ene-1-carbonyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40276", "l": "hexadecanedioyl-CoA + O2 => (2E)-hexadecenedioyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45926", "l": "4-hydroxy-6-(2-oxoundec-10-en-1-yl)pyran-2-one + 3 CO2 + 4 CoA => 9-decenoyl-CoA + 3 H(+) + 3 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38203", "l": "19-hydroxyandrost-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 19-oxo-androst-4-ene-3,17-dione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050448", "l": "beta-cyclopiazonate dehydrogenase activity"}, {"i": "RHEA:14525", "l": "A + beta-cyclopiazonate = AH2 + alpha-cyclopiazonate"}, {"i": "EC:1.21.99.1", "l": "\"Beta-cyclopiazonate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140806", "l": "SERPINC1 binds SERPINC1 activators (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34021", "l": "a fatty acid + glycerol + H(+) => a 1-acylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65133", "l": "2-oxoglutarate + O2 + preaustinoid A1 => CO2 + H2O + preaustinoid A2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981926", "l": "RAC1 and CDC42 activate PAK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50461", "l": "a medium chain fatty acid + ATP + holo-[ACP] => a medium-chain fatty acyl-[ACP] + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050474", "l": "(S)-norcoclaurine synthase activity"}, {"i": "RHEA:16173", "l": "(4-hydroxyphenyl)acetaldehyde + dopamine = (S)-norcoclaurine + H2O"}, {"i": "EC:4.2.1.78", "l": "\"(S)-norcoclaurine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57404", "l": "NAD(+) + narcotine hemiacetal = H(+) + NADH + noscapine"}, {"i": "EC:1.1.1.415", "l": "\"Noscapine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16498", "l": "adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3777129", "l": "HDAC3 containing complexes deacetylate histone (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46548", "l": "2 [Fe(II)-cytochrome b5] + a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + 2 H2O + N-acyl-(4E,8E,10E)-sphingatrienine"}, {"i": "EC:1.14.19.19", "l": "\"Sphingolipid 10-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801195", "l": "STEAP3 binds BNIP3L (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56096", "l": "[protein]-C-terminal Gly-Gly + ATP + H(+) = [protein]-C-terminal Gly-Gly-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63783", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44452", "l": "3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047945", "l": "L-glutamine:pyruvate aminotransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043907", "l": "Cys-tRNA(Pro) hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27925", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O + O2 <=> 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183067", "l": "Localization of CBL:GRB2 to the membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18110", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56483", "l": "(4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 <=> (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061543", "l": "3-demethylubiquinol-6 3-O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.99.-", "l": "\"With H(+) as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31944", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38350", "l": "(S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate <=> 2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47568", "l": "ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose = ganglioside GD1b (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215391", "l": "PRMT5 is tyrosine phosphorylated by JAK2 V617F (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22776", "l": "2 H(+) + H2O2 + 2 Mn(2+) = 2 H2O + 2 Mn(3+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57289", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O => a guanosine in RNA + H(+) + lactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21907", "l": "(2R)-2,3-bisphosphoglycerate + H2O <=> (2R)-3-phosphoglycerate + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001530", "l": "lipopolysaccharide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64448", "l": "L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine = 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.370", "l": "\"[Histone H3]-lysine(4) N-dimethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034919", "l": "butyryl-CoA 2-C-propionyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120146", "l": "sulfatide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013438", "l": "RHOD binds effectors at the endosome membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807585", "l": "BPI binds LPS on the bacterial surface (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42994", "l": "(R)-nephthenol + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55582", "l": "AMP + 2 H(+) + N(5)-phospho-L-glutamine + phosphate => ATP + H2O + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69152", "l": "Removal of remaining Flap (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43166", "l": "7-cyano-7-carbaguanosine(15) in tRNA + guanine => 7-cyano-7-deazaguanine + guanosine(15) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13216", "l": "H2O + NADP(+) + succinate semialdehyde <=> 2 H(+) + NADPH + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26042", "l": "beta-D-fructose 6-phosphate + GDP-alpha-D-mannose <=> beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18458", "l": "D-ribulose 5-phosphate => (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450325", "l": "c-FOS activation by phospho ERK1/2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374686", "l": "L1 interaction with Integrins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60829", "l": "a 5'-end triphospho-adenosine in mRNA + H2O => a 5'-end diphospho-adenosine in mRNA + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33935", "l": "2 N(omega)-hydroxy-L-arginine + NADH + 2 O2 = H(+) + 2 H2O + 2 L-citrulline + NAD(+) + 2 nitric oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977228", "l": "Sialyltransferase I can add sialic acid to the T antigen at the alpha 6 position (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33202", "l": "butan-1-ol + NAD(+) <=> butanal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25345", "l": "H2O + urea <=> carbamate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74718", "l": "Internalisation of the insulin receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427514", "l": "eNoSC deacetylates histone H3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13316", "l": "H2O + O2 + sarcosine <=> formaldehyde + glycine + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "79.238648346243679", "identifiers": [{"i": "GO:0061629", "l": "RNA polymerase II-specific DNA-binding transcription factor binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050346", "l": "trans-L-3-hydroxyproline dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875523", "l": "MET binds TNS3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8980691", "l": "RHOA GEFs activate RHOA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54164", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-(N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27500", "l": "3'-O-methyltricetin + S-adenosyl-L-methionine <=> 3',5'-di-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16649", "l": "(S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-3'-hydroxy-N-methylcoclaurine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.102", "l": "\"N-methylcoclaurine 3'-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61471", "l": "a cytidine in tRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17668", "l": "L-lysyl-[protein] + octanoyl-[ACP] <=> H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047777", "l": "(S)-citramalyl-CoA lyase activity"}, {"i": "MetaCyc:CITRAMALYL-COA-LYASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47324", "l": "(S)-3-amino-3-phenylpropanoate + pyruvate = 3-oxo-3-phenylpropanoate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050449", "l": "casbene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.56", "l": "\"Caspase-3\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656252", "l": "Defective OGG1 mutants do not excise FapyG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086081", "l": "cell adhesive protein binding involved in atrial cardiac muscle cell-AV node cell communication"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53934", "l": "19-hydroxy-prostaglandin I2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin I2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869575", "l": "TFAP2A in complex with DEK binds the APOE gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000319", "l": "BORA binds PLK1 and AURKA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36742", "l": "heptadecasphing-4-enine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-heptadecasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102452", "l": "bisdemethoxycurcumin synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814671", "l": "Fusion of late-endosome derived vesicles at the TGN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878178", "l": "The complex of RUNX3, SMAD3 and SMAD4 binds the CDKN1A gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0015378", "l": "sodium:chloride symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19417", "l": "[phosphate](n) + dolichyl diphosphate = [phosphate](n+1) + dolichyl phosphate"}, {"i": "EC:2.7.4.20", "l": "\"Dolichyl-diphosphate--polyphosphate phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37559", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210824", "l": "HNF6-dependent synthesis of HNF1B protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43447", "l": "1,2-ditetradecanoyl-sn-glycerol + ATP <=> 1,2-ditetradecanoyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60821", "l": "H2O + NADPH => adenosine 3',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50024", "l": "dodecanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + dodecanoyl-4'-phosphopantetheine + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.104", "l": "\"3-dehydro-4-phosphotetronate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49163", "l": "1,4-cineole + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-exo-hydroxy-1,4-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64125", "l": "H2O + N-hexadecanoyl-L-phenylalanine => hexadecanoate + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34215", "l": "4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+) = 4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH"}, {"i": "EC:1.2.1.83", "l": "\"3-succinoylsemialdehyde-pyridine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.64", "l": "\"3-demethylubiquinol 3-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211959", "l": "CYP3A43 6b-hydroxylates TEST (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2106625", "l": "Duplex siRNA is loaded into Argonaute (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9658253", "l": "RAS:GTP binds PI3K (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20198", "l": "[heparosan-N-sulfate](n) => [heparan-N-sulfate](n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483089", "l": "PE is converted to PS by PTDSS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465940", "l": "atRAL is reduced to atROL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51697", "l": "desmethylxanthohumol + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + xanthohumol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46068", "l": "(3E)-nonenoyl-CoA = (2E)-nonenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62743", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) <=> 1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15287", "l": "diphosphate + N(6)-(dimethylallyl)adenosine 5'-phosphate => AMP + dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5252072", "l": "AZGP1 binds PIP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694527", "l": "Loss of SAR1B GTPase (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3215406", "l": "PRMT5 binds WDR77 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20151", "l": "3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + quinine + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35137", "l": "L-alanyl-L-glutamate(in) => L-alanyl-L-glutamate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.79", "l": "\"Granzyme B\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14759", "l": "2 [Fe(II)cytochrome c] + 3 H(+) + L-ascorbate => 2 [Fe(III)cytochrome c] + L-galactono-1,4-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44386", "l": "1-heptadecanoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA => 1-heptadecanoyl-sn-glycero-3-phosphate + dodecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102370", "l": "lupeol 28-monooxygenase activity"}, {"i": "MetaCyc:RXN-13497"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209944", "l": "25(OH)D binds GC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169921", "l": "Glycosylation and Folding of HA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15722", "l": "glycine + H2O + NAD(+) => glyoxylate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56558", "l": "delta-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111879", "l": "PIP2 hydrolysis (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37997", "l": "2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate => all-trans-nonaprenyl diphosphate + H(+) + homogentisate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56575", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose <=> globoside Gb3Cer + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16106", "l": "a (3S)-3-hydroxyacyl-CoA => a (2E)-enoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15337", "l": "H2O + phenylglyoxylyl-CoA = CoA + H(+) + phenylglyoxylate"}, {"i": "EC:3.1.2.25", "l": "\"Phenylacetyl-CoA hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4332356", "l": "CAMK2 binds MAP3K7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17130", "l": "ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide => 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28934", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate <=> 4-carboxy-2-hydroxy-cis,cis-muconate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30934", "l": "L-cysteine + O-acetyl-L-homoserine <=> acetate + H(+) + L,L-cystathionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3149539", "l": "MTR transfers CH3 group from MTHF to cob(I)alamin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3878123", "l": "Initiation of SAHF formation (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37331", "l": "H2O + L-methionyl-L-alanine = L-alanine + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033785", "l": "heptose 7-phosphate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202541", "l": "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18094", "l": "5,6-dihydrouracil + NADP(+) => H(+) + NADPH + uracil"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983427", "l": "Expression of peptide bound class I MHC on cell surface (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693608", "l": "Initial resection of double-strand break ends (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32927", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = a 1,2-diacyl-sn-glycerol + H(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11005", "l": "2 H(+) + NADH + O2 + salicylate => catechol + CO2 + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72180", "l": "Cleavage of mRNA at the 3'-end (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.99.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54759", "l": "deamido-NAD(+) + hydrogencarbonate <=> AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953037", "l": "E2F8 forms homodimers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49222", "l": "CMP-beta-3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + diphosphate => 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + CTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48489", "l": "all-trans-retinol--[retinol-binding protein] + NAD(+) => all-trans-retinal--[retinol-binding protein] + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17546", "l": "[peroxiredoxin]-S-hydroxy-S-oxy-L-cysteine + [protein]-dithiol + ATP => [peroxiredoxin]-S-hydroxy-L-cysteine + [protein]-disulfide + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48370", "l": "beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+) => beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432010", "l": "Aquaporin-1 passively transports water into cell (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72180", "l": "Cleavage of mRNA at the 3'-end (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20337", "l": "(R)-2-O-sulfolactate + H2O = (R)-lactate + H(+) + sulfate"}, {"i": "EC:3.1.6.17", "l": "\"D-lactate-2-sulfatase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004115", "l": "3',5'-cyclic-AMP phosphodiesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202233", "l": "Inactivation of Lck by Csk (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097260", "l": "eoxin A4 synthase activity"}, {"i": "REACT:R-HSA-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174255", "l": "Degradation multiubiquitinated Cyclin A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390597", "l": "Release Of ADP From Myosin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102470", "l": "6C-naringenin dibenzoylmethane tautomer glucosyltransferase activity"}, {"i": "MetaCyc:RXN-14075"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25879", "l": "L-aspartate + O2 <=> H2O2 + iminosuccinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65566", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine => (9Z)-octadecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64852", "l": "benzoyl-CoA + octan-1-ol = CoA + octyl benzoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848776", "l": "PTK6 phosphorylates DOK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16420", "l": "(S)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+) <=> H(+) + L-glutamate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201519", "l": "ALK:PTN dimerization (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103048", "l": "tRNA m2A37 methyltransferase activity"}, {"i": "MetaCyc:RXN0-7007"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2129353", "l": "Tropoelastin associates with microfibrils (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.26", "l": "\"Peptide-tryptophan 2,3-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938887", "l": "PML binds RUNX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047117", "l": "enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690702", "l": "LYN phosphorylates CD22 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40175", "l": "O2 + octanoyl-CoA = (2E)-octenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58445", "l": "N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350598", "l": "Arginine<=>Agmatine+CO2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17647", "l": "N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate => H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14172", "l": "ATP + CoA + glutarate <=> ADP + glutaryl-CoA + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47344", "l": "3beta-hydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta,26-dihydroxycholest-5-en-7-one + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202203", "l": "Recruitment of PI3K to plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61299", "l": "5-deoxy-alpha-D-ribose 1-phosphate <=> 5-deoxy-D-ribulose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18256", "l": "(S)-malate + NADP(+) <=> CO2 + NADPH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.244", "l": "\"Protein N-terminal methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052810", "l": "1-phosphatidylinositol-5-kinase activity"}, {"i": "REACT:R-HSA-1675866", "l": "PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61910", "l": "2 AMP + asperphenamate + 2 diphosphate + H(+) => 2 ATP + benzoate + L-phenylalanine + N-benzoyl-L-phenylalaninol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112429", "l": "Formation of FACT complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39991", "l": "(4R)-hydroxyeicosasphinganine + a fatty acyl-CoA = CoA + H(+) + N-acyl-4-hydroxyeicosasphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30731", "l": "butanoyl-CoA + FAD + H(+) = (2E)-butenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41996", "l": "globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose = globoside GalGb4Cer (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018515", "l": "pimeloyl-CoA dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29657", "l": "L-cysteine(out) => L-cysteine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938356", "l": "RMB14 binds RUNX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13854", "l": "4-methylene-L-glutamate + ATP + NH4(+) => 4-methylene-L-glutamine + AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177942", "l": "EGFR binds EGF ligand (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6792491", "l": "TP53 stimulates CCNG1 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39090", "l": "decanedioyl-CoA + O2 <=> (2E)-decenedioyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102624", "l": "scutellarein 7-methyl ether 4'-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-15529"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45734", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate => D-ribulose 5-phosphate + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64168", "l": "2-ethyl-L-serine = (2S)-2-aminobutanoate + formaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73806", "l": "AIR + CO2 => CAIR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55854", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA => [(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64353", "l": "3 H(+) + hexanoyl-CoA + 3 malonyl-CoA => 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39820", "l": "2 [Fe(II)-cytochrome b5] + docosanoate + 2 H(+) + O2 => 2-hydroxydocosanoate + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187506", "l": "Translocation of p27 to the nucleoplasm (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14123", "l": "3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615023", "l": "PLXNA4 gene expression is stimulated by FOXO6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090523", "l": "cytochrome-b5 reductase activity, acting on NADPH"}, {"i": "RHEA:64576", "l": "2 [Fe(III)-cytochrome b5] + NADPH = 2 [Fe(II)-cytochrome b5] + H(+) + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44822", "l": "2-demethylmenaquinol-13 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-tridecaprenyl diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25237", "l": "ATP + CDP = ADP + CTP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052620", "l": "thymine dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944215", "l": "Association of procollagen type XX (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803838", "l": "FGFR2c-specific alternative splicing produces FGFR2c transcript (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42326", "l": "3 H(+) + oxidized coenzyme F420-(gamma-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] => 2 oxidized [2Fe-2S]-[ferredoxin] + reduced coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28978", "l": "H(+)(out) + L-asparagine(in) <=> H(+)(in) + L-asparagine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804402", "l": "TP53 binds POU4F1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050214", "l": "progesterone monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044596", "l": "3-demethylubiquinol-10 3-O-methyltransferase activity"}, {"i": "REACT:R-HSA-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31271", "l": "1-hydroxy-2-naphthoate + 2 H(+) + NADH + O2 = CO2 + H2O + NAD(+) + naphthalene-1,2-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19263", "l": "ADP + H(+) + heme b(out) + phosphate => ATP + H2O + heme b(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798020", "l": "TP53 binds the BTG2 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42768", "l": "a (2S)-2-hydroxycarboxylate + NADP(+) = a 2-oxocarboxylate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69173", "l": "Joining of adjacent Okazaki fragments (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60109", "l": "(R)-3-(4-hydroxyphenyl)lactoyl-CoA => (E)-4-coumaroyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34589", "l": "CO2 + pentalenolactone F + succinate => 2-oxoglutarate + O2 + pentalenolactone E"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17094", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53817", "l": "hydrogen sulfide + O-succinyl-L-serine => L-cysteine + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191763", "l": "snRNP:Snurportin complex formation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16405", "l": "benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) = benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH"}, {"i": "EC:1.1.1.217", "l": "\"Benzyl-2-methyl-hydroxybutyrate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.358"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61999", "l": "L-lysyl-[protein] + lactoyl-CoA <=> CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13492", "l": "(S)-canadine + H(+) + 2 O2 <=> berberine + 2 H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23286", "l": "dimethylallyl diphosphate => isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043761", "l": "archaetidylserine synthase activity"}, {"i": "EC:2.7.8.38", "l": "\"Archaetidylserine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614461", "l": "Tetramerization of procollagen VI (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026000", "l": "Epoxide hydrolase hydrolyses 16(S),17(S)-epoxy-DPAn-3 to PD1n-3DPA or PD2n-3DPA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5682026", "l": "MRN bound to shortened telomeres activates ATM (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35235", "l": "H(+)(out) + tetracycline(in) = H(+)(in) + tetracycline(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:1901239", "l": "malonate(1-) transmembrane transporter activity"}, {"i": "RHEA:33115", "l": "malonate(in) = malonate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682011", "l": "LC3 binds ATG7 dimer (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60939", "l": "an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an (omega-1)-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21404", "l": "chloride + O2 = chlorite"}, {"i": "EC:1.13.11.49", "l": "\"Chlorite O(2)-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004867", "l": "serine-type endopeptidase inhibitor activity"}, {"i": "REACT:R-HSA-159001", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432148", "l": "Fgr may phosphorylate p38 MAPK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36605", "l": "(3S)-3-hydroxy-L-enduracididine + CO2 + succinate => 2-oxoglutarate + L-enduracididine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.99.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2990882", "l": "CDK1 phosphorylates NUP98 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654573", "l": "Activated FGFR1 binds SHC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15217", "l": "ecdysone + hexadecanoyl-CoA = CoA + ecdysone hexadecanoate"}, {"i": "EC:2.3.1.139", "l": "\"Ecdysone O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34794", "l": "2-hydroxyethylphosphonate + O2 <=> formate + H(+) + hydroxymethylphosphonate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050645", "l": "limonoid glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42421", "l": "2-oxoglutarate + L-lysine + O2 => (4R)-4-hydroxy-L-lysine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015529", "l": "raffinose:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3204318", "l": "cob(II)alamin binds to MTRR:MTR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161791", "l": "15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983374", "l": "p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061897", "l": "all-trans retinal 3,4-desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981892", "l": "Active G alpha (z) binds RGS proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693783", "l": "NAALADases hydrolyse NAAG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21199", "l": "5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine <=> L-methionine + tetrahydropteroyltri-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37051", "l": "3-deacetyl-3-vinylbacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate = ATP + chlorophyllide a + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062150", "l": "amorpha-4,11-diene 12-monooxygenase activity"}, {"i": "RHEA:32999", "l": "(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.114", "l": "\"Amorpha-4,11-diene 12 monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61256", "l": "H2O + L-cysteine + O2 = 2-oxo-3-sulfanylpropanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47942", "l": "ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine => ganglioside GM2 (d18:1(4E)) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55059", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28609", "l": "L-valine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-2-methylpropanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685603", "l": "SAP and EAT2 binds SLAMF6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13979", "l": "NH4(+) + pyruvate => D-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692408", "l": "NPR2 binds NPPC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913675", "l": "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483174", "l": "PE is methylated to PC by PEMT (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102996", "l": "beta,beta digalactosyldiacylglycerol galactosyltransferase activity"}, {"i": "MetaCyc:RXN-9721"}, {"i": "EC:2.4.1.184", "l": "\"Galactolipid galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56274", "l": "4 [Fe(II)cytochrome cL] + formate + 5 H(+) => 4 [Fe(III)cytochrome cL] + H2O + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34115", "l": "carboxynorspermidine + H2O + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42299", "l": "a 1-acyl-sn-glycero-3-phosphate + a fatty acyl-[ACP] <=> a 1,2-diacyl-sn-glycero-3-phosphate + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21656", "l": "CDP-alpha-D-paratose = CDP-3,6-dideoxy-alpha-D-mannose"}, {"i": "EC:5.1.3.10", "l": "\"CDP-paratose 2-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201603", "l": "Caspase-mediated cleavage of PKC theta (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37924", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42237", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446634", "l": "IRAK4 is activated by autophosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684806", "l": "Unknown kinase phosphorylates CLEC1B dimer:PDPN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2534096", "l": "METAP1/2 demethylates GNAT1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49505", "l": "phosphinomethylmalate => phosphinomethylisomalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689861", "l": "Recruitment of XPA and release of CAK  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41932", "l": "H2O + hexadecanoyl-[ACP] = H(+) + hexadecanoate + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36052", "l": "beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O => 2 beta-L-arabinofuranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295613", "l": "SPRY2 binds GRB2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0010178", "l": "IAA-amino acid conjugate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018634", "l": "alpha-pinene monooxygenase [NADH] activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429767", "l": "Passive I- efflux mediated by SMCT1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40659", "l": "1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167148", "l": "TFIIS-mediated recovery of elongation from arrest (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43773", "l": "guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63142", "l": "taurine + tetracosanoate => H2O + N-tetracosanoyl-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44255", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047326", "l": "inositol tetrakisphosphate 5-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62309", "l": "(+)-premalbrancheamide + chloride + FAD + 2 H(+) => (+)-malbrancheamide B + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390909", "l": "HRH2 binds hist (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53600", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48054", "l": "n adenosine 3',5'-bisphosphate + dermatan 4'-sulfate + n H(+) => n 3'-phosphoadenylyl sulfate + dermatan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64313", "l": "2 chloride + 2 FADH2 + 2 O2 + sulochrin => dihydrogeodin + 2 FAD + H(+) + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20872", "l": "(20S)-ginsenoside Rd + UDP-alpha-D-glucose = (20S)-ginsenoside Rb1 + H(+) + UDP"}, {"i": "EC:2.4.1.314", "l": "\"Ginsenoside Rd glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54308", "l": "pseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28404", "l": "ADP + H(+) + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10026", "l": "H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine => L-lysyl-[histone] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54937", "l": "(2E)-decenoyl-[ACP] + H(+) + NADH => decanoyl-[ACP] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18062", "l": "5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran => methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084903", "l": "Collagen types VI, IX bind integrin alpha10beta1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210805", "l": "Removal of miRNA passenger strand (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.57", "l": "\"Caspase-4\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193068", "l": "CYP17A1 17-hydroxylates PREG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50044", "l": "an acyl-CoA + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59423", "l": "H2O + methylamine + O2 <=> formaldehyde + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14322", "l": "morphine + NADP(+) => H(+) + morphinone + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008260", "l": "3-oxoacid CoA-transferase activity"}, {"i": "EC:2.8.3.5", "l": "\"3-oxoacid CoA-transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56459", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole <=> 12-epi-fischerindole U"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19984", "l": "NADP(+) + S-(hydroxymethyl)glutathione <=> H(+) + NADPH + S-formylglutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15132", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (1S,6R)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44825", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol => a 1,2-diacylglycerol + a monoacyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5226979", "l": "ADD1:ADD2 binds DMTN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944216", "l": "Association of procollagen type XV (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61551", "l": "ent-kaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> ent-7alpha-hydroxykaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16454", "l": "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O => 2-formylbenzoate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39054", "l": "ATP + cholesterol(in) + H2O <=> ADP + cholesterol(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50045", "l": "an acyl-CoA + H2O => adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1011598", "l": "DOCKs bind to RhoGEFs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25108", "l": "ATP + pyridoxine = ADP + H(+) + pyridoxine 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35196", "l": "L-quinate(in) => L-quinate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621888", "l": "Defective HK1 does not phosphorylate Glc to form G6P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578712", "l": "Importin-8 binds AGO2:miRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13182", "l": "ATP + H2O + nitrate(out) => ADP + H(+) + nitrate(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50847", "l": "(5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate <=> (5S,6S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202718", "l": "Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47050", "l": "3-dehydroshikimate + a quinol => a quinone + shikimate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24043", "l": "NADPH + 2 oxidized [cytochrome P450] <=> H(+) + NADP(+) + 2 reduced [cytochrome P450]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694522", "l": "Inner coat assembly and cargo binding (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6803527", "l": "ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64755", "l": "3-sulfanylpentan-1-ol-L-cysteine + H2O <=> 3-sulfanyl-1-pentanol + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27570", "l": "ATP + D-glycero-alpha-D-manno-heptose 7-phosphate = ADP + D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H(+)"}, {"i": "EC:2.7.1.168", "l": "\"D-glycero-alpha-D-manno-heptose-7-phosphate kinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031825", "l": "type 1F serotonin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164832", "l": "ATPase synthesizes ATP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46044", "l": "(3Z)-octenoyl-CoA = (2E)-octenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30957", "l": "7,7',9,9'-tetra-cis-lycopene + 2 a quinol => 9,9'-di-cis-zeta-carotene + 2 a quinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928624", "l": "EPHBs bind EFNBs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391377", "l": "Luteinizing hormone receptor can bind LH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22530", "l": "a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + H(+) + UDP => a flavonol 3-O-beta-D-glucoside + UDP-beta-L-rhamnose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420591", "l": "Nectin-2:Nectin 3 trans heterodimer interaction (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864595", "l": "TFAP2B homodimer binds YEATS4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62103", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57033", "l": "(E)-2-((N-methylformamido) methylene)succinate + H(+) + 2 H2O => CO2 + formate + methylamine + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.71", "l": "\"Endothelin-converting enzyme 1\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58644", "l": "N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine = (9Z,12Z,15Z)-octadecatrienamide + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43885", "l": "3-oxochol-4-en-22-oyl-CoA + NAD(+) => 3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50794", "l": "aldosterone + 2 H2O + 2 oxidized [adrenodoxin] => 18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65203", "l": "S-(acetaldehyde)-L-cysteine <=> (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41609", "l": "3'-phosphoadenylyl sulfate + alpha,alpha-trehalose => 2-O-sulfo-alpha,alpha-trehalose + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952069", "l": "HDAC4 deacetylates RUNX3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20827", "l": "adenosine + ATP <=> ADP + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17979", "l": "a long-chain fatty acid + 3 H(+) + 2 NADH => a long-chain primary fatty alcohol + H2O + 2 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2152276", "l": "Secretion of transmembrane collagens (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56130", "l": "AH2 + diphosphate + flavuxanthin => A + dimethylallyl diphosphate + H2O + nonaflavuxanthin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69053", "l": "RFC binding displaces Pol Alpha (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38161", "l": "(2S,3R)-capreomycidine + H2O => (2S,3S)-hydroxyarginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58459", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O <=> (R)-glycerate + D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14011", "l": "(R,R)-chrysanthemyl diphosphate + diphosphate => 2 dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683925", "l": "ULK1 is dephosphorylated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418091", "l": "F2R binds ARRB1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17379", "l": "3-O-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+) => dolichyl beta-D-mannosyl phosphate + L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52566", "l": "3-dehydro-L-erythronate => 2-dehydro-L-erythronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14592", "l": "luteolin + S-adenosyl-L-methionine <=> chrysoeriol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050142", "l": "nitrogenase (flavodoxin) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54176", "l": "a long-chain fatty aldehyde + holo-[ACP] + NADP(+) = a long-chain fatty acyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62900", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc + GDP-beta-L-fucose = alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-GlcNAc + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16918", "l": "2,6-dihydroxypyridine + H(+) + NADH + O2 => 2,3,6-trihydroxypyridine + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10189", "l": "acetoacetyl-CoA + acetyl-CoA + H2O => (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10305", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP] => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38396", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O => (9Z)-hexadecenoate + 1,3-di-(9Z)-hexadecenoylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27732", "l": "beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate => 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419389", "l": "LPA-binding receptors bind LPA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77081", "l": "Formation of the CE:GMP intermediate complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130349", "l": "Generation of CLIP from lip10 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18957", "l": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.53", "l": "\"(R)-limonene 6-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106155", "l": "peptidyl-lysine 3-dioxygenase activity"}, {"i": "RHEA:57152", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 = (3S)-3-hydroxy-L-lysyl-[protein] + CO2 + succinate"}, {"i": "EC:1.14.11.63", "l": "\"Peptidyl-lysine (3S)-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951727", "l": "cAMP binds PKA tetramer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22488", "l": "S-(hydroxymethyl)glutathione = formaldehyde + glutathione"}, {"i": "EC:4.4.1.22", "l": "\"S-(hydroxymethyl)glutathione synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38061", "l": "1-octanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34881", "l": "4-methoxy-4-oxo-3-phenylbutanoate + NH4(+) => 2 H2O + methyl 3-cyano-2-phenylpropanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45692", "l": "N-(octanoyl)-sphing-4-enine-1-phosphate(in) = N-(octanoyl)-sphing-4-enine-1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51766", "l": "4-prenylphlorisovalerophenone + diphosphate => dimethylallyl diphosphate + phlorisovalerophenone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424476", "l": "Activation of RAC1 by VAV2/3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.28"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66465", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O => scalarane-17alpha-19-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114544", "l": "p115-RhoGEF activation of RHOA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047211", "l": "alpha-1,4-glucan-protein synthase (ADP-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420883", "l": "Opsins act as GEFs for G alpha-t (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52523", "l": "O2 + prostaglandin E1 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy prostaglandin E1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9612509", "l": "SGK phosphorylates SRF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106242", "l": "kolavenyl diphosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38663", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49513", "l": "2-(phosphinatomethylidene)butanedioate + H2O => phosphinomethylisomalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624949", "l": "Assembly of the anterograde IFT train (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15606", "l": "H2O + L-serine O-sulfate => H(+) + NH4(+) + pyruvate + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52807", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-eremophilene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31620", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose => dTDP-3-dehydro-6-deoxy-alpha-D-galactose + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31765", "l": "4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid => a 2-oxocarboxylate + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004364", "l": "glutathione transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038058", "l": "TNFSF11 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050006", "l": "isomaltulose synthase activity"}, {"i": "EC:5.4.99.11", "l": "\"Isomaltulose synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47755", "l": "5-hydroxy-3-methyl-L-tyrosine + S-adenosyl-L-methionine <=> 5-hydroxy-3-methyl-O-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45094", "l": "octanoate + sphing-4-enine => H2O + N-octanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28533", "l": "H2O + XMP <=> phosphate + xanthosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22388", "l": "acetyl-CoA + N(6)-hydroxy-L-lysine = CoA + N(6)-acetyl-N(6)-hydroxy-L-lysine"}, {"i": "EC:2.3.1.102", "l": "\"N(6)-hydroxylysine O-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204773", "l": "Interaction of Tie2 and Grb7 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65642", "l": "CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8Z)-enine => (4R)-hydroxysphing-(8Z)-enine + tetracosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50240", "l": "[hyaluronan](n) = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O"}, {"i": "EC:4.2.2.1", "l": "\"Hyaluronate lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-994148", "l": "LRRC16A binds F-actin capping protein (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018707", "l": "1-phenanthrol methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54514", "l": "(13R)-9,13-epoxylabd-14-ene + diphosphate => peregrinol diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-197958", "l": "FPGS-2 transforms THF to THFPG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990430", "l": "extracellular matrix protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391939", "l": "TP receptor can bind thromboxane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102181", "l": "4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941895", "l": "Formation of CDK4/6:CCND complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56933", "l": "androst-5-en-3beta,17beta-diol + NAD(+) => 17beta-hydroxy-androst-5-en-3-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44041", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => 14,15-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202717", "l": "Heterodimerization of CEACAMs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174202", "l": "Degradation of multiubiquitinated Securin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38620", "l": "nicotinate beta-D-ribonucleotide + phenol => H(+) + nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51692", "l": "prephenate + S-adenosyl-L-methionine = 3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46336", "l": "3-oxochola-4,17-dien-22-oyl-CoA + H2O = 17-hydroxy-3-oxochol-4-en-22-oyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58027", "l": "oleanolate + UDP-alpha-D-glucose <=> H(+) + oleanolate 3-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57940", "l": "Fe-coproporphyrin III + H(+) + H2O2 = CO2 + 2 H2O + harderoheme III"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36690", "l": "hexadecanoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-hexadecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33739", "l": "2 H(+) + hexadecanoate + NADH = H2O + hexadecanal + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247922", "l": "GGCT transforms gGluCys to OPRO (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18223", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + phosphate => 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61368", "l": "4-methylumbelliferone sulfate(in) + ATP + H2O = 4-methylumbelliferone sulfate(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40952", "l": "(2S)-2-acetamido-4-aminobutanoate + H2O => acetate + L-2,4-diaminobutanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009022", "l": "tRNA nucleotidyltransferase activity"}, {"i": "RHEA:10628", "l": "phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)"}, {"i": "EC:2.7.7.56", "l": "\"tRNA nucleotidyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799418", "l": "TP53 binds the TP53INP1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27873", "l": "(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O <=> (2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61091", "l": "(S)-eriodictyol + 2-oxoglutarate + O2 <=> (2R,3R)-dihydroquercetin + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28270", "l": "acetyl-CoA + spermidine = CoA + H(+) + N(8)-acetylspermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619367", "l": "CaMKKs phosphorylate CAMK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975097", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39259", "l": "(3R)-hydroxy-(13Z)-docosenoyl-CoA = (2E,13Z)-docosadienoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917841", "l": "Acidification of Tf:TfR1 containing endosome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35236", "l": "H(+)(out) + tetracycline(in) => H(+)(in) + tetracycline(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022911", "l": "CSPG is secreted (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29944", "l": "2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in) => 2-dehydro-3-deoxy-D-gluconate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11884", "l": "3'-phosphoadenylyl sulfate + cortisol = adenosine 3',5'-bisphosphate + cortisol 21-sulfate + H(+)"}, {"i": "EC:2.8.2.18", "l": "\"Cortisol sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814695", "l": "PERP binds desmosomes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39618", "l": "(3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA <=> (2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010428", "l": "methyl-CpNpG binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53555", "l": "(9S,10R)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(9S,10R)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626699", "l": "MARK4 binds ODF2 in the centriole (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781814", "l": "USP19 deubiquitinates RNF123 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58357", "l": "2-oxoglutarate + N(omega)-methyl-L-arginyl-[protein] + O2 => CO2 + formaldehyde + L-arginyl-[protein] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450975", "l": "isocitrate <=> citrate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28383", "l": "H2O + N(6)-(6-phospho-D-fructosyl)-L-lysine => D-glucose 6-phosphate + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685011", "l": "ATR activation at DNA DSBs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964851", "l": "Dehydratation of DHQ yields DHS (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46409", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944246", "l": "Association of procollagen type XXI (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851866", "l": "MET binds RANBP10 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26285", "l": "Co-precorrin-5B + S-adenosyl-L-methionine = Co-precorrin-6A + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.195", "l": "\"Cobalt-precorrin-5B (C(1))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.20.5", "l": "\"Flavone synthase I\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350186", "l": "CUBN binds GC:25(OH)D (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809707", "l": "MTMR12 binds MTMR2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44437", "l": "a 1,2-diacylglycerol + a 1-acylglycerol => a triacylglycerol + glycerol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990473", "l": "ciliary targeting signal binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54255", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018543", "l": "4-amino-2-nitroso-6-nitrotoluene reductase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030158", "l": "protein xylosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29748", "l": "3-phenylpropanoate(in) => 3-phenylpropanoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693609", "l": "ATM phosphorylates TP53 at S15 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36331", "l": "ATP + dimethylallyl diphosphate = diphosphate + N(6)-(dimethylallyl)adenosine 5'-triphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030619", "l": "U1 snRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028533", "l": "NR1H2,3, NRIP1 bind the FASN gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050529", "l": "polyneuridine-aldehyde esterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427337", "l": "MBD2 binds methylcytosine in chromatin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-170120", "l": "Translocation of Cdc25B to the cytoplasm (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013110", "l": "RHOC binds effectors at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169394", "l": "ISGylation of IRF3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45317", "l": "H(+) + NADPH + prostaglandin D2 => 11beta-prostaglandin F2 + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24555", "l": "5alpha-cholestan-3-one + NADP(+) <=> cholest-4-en-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000310", "l": "AURKA phosphorylates PLK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990400", "l": "mitochondrial ribosomal large subunit rRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848124", "l": "PTK6 phosphorylates STAT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48147", "l": "H2O + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-(octadecanoyl)-sphing-4-enine <=> ganglioside GT1b (d18:1(4E)/18:0) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.34", "l": "\"Plasma kallikrein\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390886", "l": "HRH4 binds Hist (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66358", "l": "(7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH => (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48771", "l": "ATP + D-erythrulose <=> ADP + D-erythrulose 4-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013004", "l": "RHOA binds effectors at the ER membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15384", "l": "O2 + quercetin <=> 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27307", "l": "A + D-proline => 1-pyrroline-2-carboxylate + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23732", "l": "(R)-5-diphosphomevalonate + ATP = ADP + CO2 + isopentenyl diphosphate + phosphate"}, {"i": "EC:4.1.1.33", "l": "\"Diphosphomevalonate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717374", "l": "SCN3A:SCN2B,4B transports Na+ from the extracellular region to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45493", "l": "[phycoerythrocyanin beta-subunit]-Cys(84)-phycocyanobilin => (2R,3E)-phycocyanobilin + apo-[phycoerythrocyanin beta-subunit]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53125", "l": "all-trans-lycopene => delta-carotene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66411", "l": "ATP + glutathione(in) + glycochenodeoxycholate(in) + H2O <=> ADP + glutathione(out) + glycochenodeoxycholate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30773", "l": "D-ribose + guanine => guanosine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944223", "l": "Association of procollagen type V (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3828025", "l": "DCN (decorin) degradation by MMP14 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52588", "l": "choloyl-CoA + NAD(+) = 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50912", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-L-ribitol = 4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)"}, {"i": "EC:2.7.8.46", "l": "\"Teichoic acid ribitol-phosphate primase\""}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0000149", "l": "SNARE binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647994", "l": "RAS proteins are depalmitoylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20828", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2"}, {"i": "EC:4.1.1.65", "l": "\"Phosphatidylserine decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37261", "l": "2-oxobutanoate + H(+) + NADH + NH4(+) => (2S)-2-aminobutanoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3595175", "l": "Defective CHST3 does not transfer SO4(2-) to chondroitin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624949", "l": "Assembly of the anterograde IFT train (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24911", "l": "L,L-cystathionine => 2-aminobut-2-enoate + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35168", "l": "minocycline(in) => minocycline(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "73.946956196949927", "identifiers": [{"i": "GO:0000976", "l": "transcription cis-regulatory region binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25336", "l": "H(+) + L-cysteine + tRNA(Cys) => H2O + L-cysteinyl-tRNA(Cys)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69685", "l": "CHEK2 phosphorylates TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797553", "l": "Protein 4.1 binds CASK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2129357", "l": "Fibrillin C-terminal processing (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2509827", "l": "ITPA hydrolyses ITP to IMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72180", "l": "Cleavage of mRNA at the 3'-end (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37834", "l": "(S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 <=> 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0051731", "l": "polynucleotide 5'-hydroxyl-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38352", "l": "(R)-3-phenyllactate + NAD(+) => 3-phenylpyruvate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70479", "l": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32735", "l": "1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine"}, {"i": "RHEA:32739", "l": "1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.71", "l": "\"Phosphatidyl-N-methylethanolamine N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64647", "l": "butan-1-ol + propanoyl-CoA <=> butyl propanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11395", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O <=> 1D-myo-inositol 1,3,4-trisphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37520", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20993", "l": "16-hydroxytabersonine + S-adenosyl-L-methionine => 16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46357", "l": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] => 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5684140", "l": "ATM phosphorylates RBBP8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46280", "l": "2 [Fe(II)-cytochrome b5] + an N-acylsphing-4-enine + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 H2O"}, {"i": "EC:1.14.19.18", "l": "\"Sphingolipid 8-(E)-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38555", "l": "an all-trans-retinyl ester + H2O = a fatty acid + all-trans-retinol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16806", "l": "2-oxoglutarate + deacetoxycephalosporin C + O2 => CO2 + deacetylcephalosporin C + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1454916", "l": "The ABCC family mediates organic anion transport (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41512", "l": "L-ornithine + NADH + O2 = H2O + N(5)-hydroxy-L-ornithine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-354060", "l": "Translocation of RIAM to plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65351", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA <=> 3-oxochol-4,6-dien-24-oyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952807", "l": "p-Y693-STAT4 dissociates after IL12:IL12R interaction (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43561", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48009", "l": "2-hydroxybenzoyl-CoA + H(+) + NADH + O2 => 2,5-dihydroxybenzoyl-CoA + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50268", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate = (5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49878", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38135", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534365", "l": "Slo3 Potassium Transport (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51522", "l": "(S)-tembetarine + H(+) + S-adenosyl-L-homocysteine => (S)-reticuline + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28840", "l": "H(+)(out) + Zn(2+)(in) => H(+)(in) + Zn(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159005", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.47", "l": "\"Alternative-complement-pathway C3/C5 convertase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048406", "l": "nerve growth factor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56525", "l": "A + dihydro-heme d1 => AH2 + heme d1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391865", "l": "Recruitment of FAK to NCAM1:Fyn in lipid rafts (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65217", "l": "3-oxododecanoyl-CoA + H2O => 3-oxododecanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24402", "l": "ADP + UDP => ATP + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41986", "l": "acetone + H(+) + NADH => NAD(+) + propan-2-ol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004020", "l": "adenylylsulfate kinase activity"}, {"i": "RHEA:24152", "l": "adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)"}, {"i": "EC:2.7.1.25", "l": "\"Adenylyl-sulfate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55708", "l": "[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide"}, {"i": "EC:2.4.2.60", "l": "\"Cysteine-dependent adenosine diphosphate thiazole synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130151", "l": "Dimerization of DAP12 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58857", "l": "(6E)-8-hydroxygeraniol + NAD(+) => (6E)-8-oxogeraniol + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17342", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) => 1-hexadecanoylglycerone 3-phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205319", "l": "Interaction of APS and p-KIT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050422", "l": "strictosidine beta-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-481010", "l": "Surface deployment of platelet dense granule membrane components (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20598", "l": "2 L-cysteine + NAD(+) => H(+) + L-cystine + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45800", "l": "15-demethylaclacinomycin T + AH2 + O2 = 10-decarboxymethylaclacinomycin T + A + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60982", "l": "12-oxododecanoate + H(+) + NADH => 12-hydroxydodecanoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850961", "l": "PREX2 binds PTEN and inhibits it (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60316", "l": "N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12624", "l": "H(+) + L-aspartate <=> CO2 + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093332", "l": "p-EPHB phosphorylates SDC2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54036", "l": "[mycoredoxin]-L-cysteine + arseno-mycothiol + H(+) = [mycoredoxin]-S-mycothiol-L-cysteine + arsenite"}, {"i": "EC:1.20.4.3", "l": "\"Mycoredoxin\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004671", "l": "protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000319", "l": "BORA binds PLK1 and AURKA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733960", "l": "Bile salts and acids dissociate from ALB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14107", "l": "1-pyrroline-5-carboxylate + 2 H(+) + NADH => L-proline + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42887", "l": "(R)-mevalonate + ATP <=> (R)-3-phosphomevalonate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004106", "l": "chorismate mutase activity"}, {"i": "RHEA:13897", "l": "chorismate = prephenate"}, {"i": "EC:5.4.99.5", "l": "\"Chorismate mutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5617179", "l": "PRKACA phosphorylates TNNI3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21430", "l": "H(+) + pyruvate + sulfite => (R)-3-sulfolactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42066", "l": "2',3'-cGAMP + 2 diphosphate => ATP + GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12129", "l": "2 L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-oxoglutarate + 2 H(+) + L-glutamine + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75081", "l": "Formation of AT-AC B Complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32682", "l": "(2E)-geranyl diphosphate + H2O <=> (2E)-geraniol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392870", "l": "Gs activation by prostacyclin receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36525", "l": "(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65274", "l": "chrodrimanin H + H2O + NADP(+) => chrodrimanin C + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35083", "l": "diacetylchitobiose-6'-phosphate + H2O = acetate + N'-monoacetylchitobiose-6'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37739", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine = 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoserine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15018", "l": "a phosphate monoester + H2O => an alcohol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27700", "l": "beta-L-galactose 1-phosphate + GDP + H(+) => GDP-beta-L-galactose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1638845", "l": "CERK phosphorylates CERA to form C1P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937792", "l": "RUNX3 binds SRC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30906", "l": "demethylspheroidene + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + spheroidene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.263", "l": "\"Abscisate beta-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14545", "l": "H2O + nicotinamide = NH4(+) + nicotinate"}, {"i": "EC:3.5.1.19", "l": "\"Nicotinamidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683792", "l": "p-T68-CHEK2 autophosphorylates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098600", "l": "selenomethionine gamma-lyase activity"}, {"i": "REACT:R-HSA-2408537", "l": "Excess SeMet is cleaved into MeSeH by PXLP-K212-CTH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55312", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23313", "l": "2 sucrose => 1(F)-beta-D-fructosylsucrose + D-glucose"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0031811", "l": "G protein-coupled nucleotide receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64967", "l": "dUTP + 2 H2O <=> dUMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46338", "l": "17-hydroxy-3-oxochol-4-en-22-oyl-CoA => 3-oxochola-4,17-dien-22-oyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654511", "l": "FGFRL1 dimer binds FGFs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200406", "l": "CPT1A,B transfers PALM to CAR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57823", "l": "[phosphate](n) + ADP <=> [phosphate](n+1) + AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45804", "l": "ATP + hydroxylamine + L-glutamate = ADP + L-glutamine hydroxamate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20956", "l": "2-phenylacetate + ATP + CoA = AMP + diphosphate + phenylacetyl-CoA"}, {"i": "EC:6.2.1.30", "l": "\"Phenylacetate--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592278", "l": "Autocatalytic activation of proMMP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389532", "l": "PP2A binds CTLA4 dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9611852", "l": "ADRB3 bind ADR,NAd (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42868", "l": "norspermine + S-adenosyl 3-(methylsulfanyl)propylamine = caldopentamine + 2 H(+) + S-methyl-5'-thioadenosine"}, {"i": "EC:2.5.1.127", "l": "\"Caldopentamine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37591", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA = 1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61223", "l": "1,2-dihexadecanoyl-sn-glycero-3-CDP + 1D-myo-inositol 3-phosphate <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47247", "l": "(2R)-3-phosphoglycerate + an NDP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873918", "l": "Transphosphorylation of JAK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16094", "l": "(24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24R)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24936", "l": "H2O + imidazol-4-one => N-formimidoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30234", "l": "H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine <=> (2E,6E)-farnesal + H2O2 + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788975", "l": "Superoxide anion dismutates to H2O2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41426", "l": "formate + grixazone A + H(+) + 3 H2O => 2 3-amino-4-hydroxybenzaldehyde + N-acetyl-L-cysteine + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917696", "l": "Cargo Sequestration (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23852", "l": "catechol + O2 = cis,cis-muconate + 2 H(+)"}, {"i": "EC:1.13.11.1", "l": "\"Catechol 1,2-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48793", "l": "GDP-beta-L-fucose + Lc4Cer => alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26023", "l": "8'-apo-beta-carotenol + O2 = (3E,5E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal"}, {"i": "EC:1.13.11.67", "l": "\"8'-apo-beta-carotenoid 14',13'-cleaving dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986940", "l": "MET gene transcription is stimulated by MECP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696822", "l": "AKR1B15 reduces EST17b to E1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22071", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) <=> (2S)-2-acetolactate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390120", "l": "Phosphorylated HPO dimer phosphorylates TH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621370", "l": "SYK autophosphorylates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60605", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine => 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19052", "l": "(5R)-5-hydroxy-L-lysine + GTP <=> (5R)-5-phosphooxy-L-lysine + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050456", "l": "cystine reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805276", "l": "CDK5 phosphorylates TP53 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53706", "l": "H(+) + prostaglandin E2 + sn-glycero-3-phosphoethanolamine => 2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38775", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694433", "l": "MIA2 binds PREB (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004766", "l": "spermidine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691004", "l": "XPC binds RAD23 and CETN2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25837", "l": "3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O => 5-deoxy-D-glucuronate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018718", "l": "1,2-dihydroxy-phenanthrene glycosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42045", "l": "GDP-beta-L-fucose + globoside GalGb4Cer (d18:1(4E)) => GDP + globoside Globo-H (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52831", "l": "(1S,4R)-isodihydrocarvone + H(+) + NADPH + O2 <=> (3S,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912388", "l": "NICD1 displaces co-repressor complex from RBPJ (CSL) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19556", "l": "H2O + L-tryptophan <=> indole + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34536", "l": "H(+) + hexadecanoyl-CoA + L-alanine => 1-deoxy-3-dehydrosphinganine + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47377", "l": "(25R)-3beta,26-dihydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta-hydroxycholest-5-en-7-one-26-al + 2 H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38823", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28766", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-D-galactose <=> CoA + dTDP-4-acetamido-4,6-dideoxy-D-galactose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16357", "l": "A + succinate = AH2 + fumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51495", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59408", "l": "H2O + N-acetyl-L-aspartate = acetate + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45702", "l": "formaldehyde + H2O2 + N,N-dimethylglycine => glycine betaine + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33803", "l": "H2O + L-histidinal + NAD(+) = 2 H(+) + L-histidine + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13960", "l": "4 H2O + O2 + 4 sulfur <=> 6 H(+) + 2 hydrogen sulfide + 2 sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686920", "l": "PELI1 ubiquitinates RIPK3 at K363 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357483", "l": "RAC1 binds PAK1-3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15399", "l": "2 chloride + formaldehyde + 2 H(+) => dichloromethane + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46529", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55443", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + maniladiol + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202394", "l": "Translocation of CARMA1 to Plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63413", "l": "2,4,6-trichlorophenol + FADH2 + O2 => 2,6-dichlorobenzoquinone + chloride + FAD + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18111", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65608", "l": "(4R)-hydroxysphinganine + docosanoyl-CoA = CoA + H(+) + N-docosanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22418", "l": "catechol + CO2 => 3,4-dihydroxybenzoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49846", "l": "(-)-dehydrodiconiferyl acid ketone + a quinol => (-)-dehydrodiconiferyl acid + a quinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37686", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA <=> 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44125", "l": "hexadecanoyl-CoA + tetradecan-1-ol => CoA + tetradecanyl hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "81.20444558259193", "identifiers": [{"i": "GO:0090563", "l": "protein-phosphocysteine-sugar phosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53197", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 16alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31544", "l": "all-trans-zeaxanthin + 2 UDP-alpha-D-glucose => 2 H(+) + 2 UDP + zeaxanthin bis(beta-D-glucoside)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19876", "l": "3beta-sulfooxy-androst-5-en-17-one + H2O <=> 3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607002", "l": "Activated protein C cleaves factor VIIIa (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004530", "l": "deoxyribonuclease I activity"}, {"i": "MetaCyc:3.1.21.1-RXN"}, {"i": "EC:3.1.21.1", "l": "\"Deoxyribonuclease I\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45184", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + NH4(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854981", "l": "SHC1 in the RET complex is phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45101", "l": "6-demethylmitomycin B + S-adenosyl-L-methionine => mitomycin B + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23520", "l": "acetyl-CoA + propanoate = acetate + propanoyl-CoA"}, {"i": "EC:2.8.3.1", "l": "\"Propionate CoA-transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865182", "l": "OTUD7A hydrolyses K11diUb (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111237", "l": "Formation of ADAR1 homodimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005292", "l": "high-affinity lysine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23963", "l": "H(+) + 2 H2O2 + hexadecanoate <=> CO2 + 3 H2O + pentadecanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24122", "l": "20-hydroxy-leukotriene E4 + H2O + NADP(+) => H(+) + leukotriene E4 + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47504", "l": "chenodeoxycholate + NADP(+) = 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51102", "l": "16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805426", "l": "CARD8 binds CASP9(1-416) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023617", "l": "Butyrylcholinesterase hydrolyzes acyl Ghrelin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015654", "l": "tellurite transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53789", "l": "allodeoxycholoyl-CoA + beta-muricholate => allodeoxycholate + beta-muricholoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451033", "l": "(S)-Malate <=> Fumarate + H2O (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41793", "l": "holo-[ACP] + malonyl-CoA => CoA + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.136"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870465", "l": "RGGT binds the RAB-binding subunit (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008758", "l": "UDP-2,3-diacylglucosamine hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59950", "l": "CoA + H(+) + prostaglandin F2alpha => H2O + prostaglandin F2alpha-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333615", "l": "80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425861", "l": "Activation of Protein Kinase C novel isoforms (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10334", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA => a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22704", "l": "2 H2O + ricinine = 4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4(+)"}, {"i": "EC:3.5.5.2", "l": "\"Ricinine nitrilase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372449", "l": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58317", "l": "beta-D-glucosyl-N-hexadecanoylsphing-4E-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65363", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O <=> a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102930", "l": "4-hydroxybenzoate geranyltransferase activity"}, {"i": "MetaCyc:RXN-8920"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29661", "l": "O-acetyl-L-serine(out) => O-acetyl-L-serine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53347", "l": "5,6-dihydrouridine(20a) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(20a) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9653514", "l": "USP17L2 deubiquitinates RCE1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61285", "l": "H2O + L-cystine + O2 => (2R)-2-amino-2-carboxylatoethyl-disulfanyl-oxopropanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56657", "l": "12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+) => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938913", "l": "RUNX1 binds ELF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26159", "l": "D-mannose + NADP(+) <=> D-glucosone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21877", "l": "(6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) => (S)-usnate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156682", "l": "PLK1 phosphorylates NUDC (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141310", "l": "FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428127", "l": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46675", "l": "aldosterone + H(+) + NADPH <=> 5beta-dihydroaldosterone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57852", "l": "a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014294", "l": "RAC2 binds effectors at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68688", "l": "CDC6 association with ORC:origin complexes mediated by MCM8 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10467", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O <=> n acetate + chitosan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606162", "l": "Phosphorylated BTK phosphorylates PLCG2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019871", "l": "sodium channel inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47268", "l": "bacterioruberin = H2O + monoanhydrobacterioruberin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39655", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2 = (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20073", "l": "D-allothreonine = acetaldehyde + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49457", "l": "(2S)-2-amino-4-deoxychorismate + H2O => (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50188", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39518", "l": "(2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH <=> (15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25727", "l": "N-hydroxy-L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018785", "l": "RHOBTB2 binds GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.34"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47341", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46389", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S,25R)-24,26-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12625", "l": "(S)-malate + 1-O-(trans-sinapoyl)-beta-D-glucose = D-glucose + sinapoyl (S)-malate"}, {"i": "EC:2.3.1.92", "l": "\"Sinapoylglucose--malate O-sinapoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938356", "l": "RMB14 binds RUNX2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39411", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA = (2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60330", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202375", "l": "Recruitment of ITK to SLP-76 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797090", "l": "CCNK binds CDK12 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36585", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH => dTDP-alpha-D-fucose + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16965", "l": "(2E)-geranyl diphosphate = beta-myrcene + diphosphate"}, {"i": "EC:4.2.3.15", "l": "\"Myrcene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419440", "l": "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57427", "l": "guaiacol + O2 + reduced [NADH--hemoprotein reductase] <=> catechol + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43554", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434130", "l": "IRAK4 binds to activated TLR5 or 15. (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.113", "l": "\"Mannosyl-oligosaccharide 1,2-alpha-mannosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848829", "l": "CBL autoubiquitinates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442749", "l": "CaMKK autophosphorylates in the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44754", "l": "6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031752", "l": "D5 dopamine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14493", "l": "H2O + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] = ADP-D-ribose + L-arginyl-[dinitrogen reductase]"}, {"i": "EC:3.2.2.24", "l": "\"ADP-ribosyl-[dinitrogen reductase] hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25815", "l": "H2O + N(1)-acetylspermidine + O2 <=> 3-acetamidopropanal + H2O2 + putrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42097", "l": "ATP + carbamoyl phosphate + H2O + tobramycin => AMP + diphosphate + H(+) + nebramycin 5' + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18739", "l": "AMP + 2 H(+) + phosphate + selenophosphate => ATP + H2O + hydrogenselenide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964759", "l": "Alternative endo-mannosidase I route (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63027", "l": "(13Z)-docosenamide + H2O <=> (13Z)-docosenoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.17"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36570", "l": "GDP-beta-L-colitose + NAD(+) <=> GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23916", "l": "H(+) + UDP-alpha-D-glucuronate = CO2 + UDP-alpha-D-xylose"}, {"i": "EC:4.1.1.35", "l": "\"UDP-glucuronate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26068", "l": "3-(hydrohydroxyphosphoryl)pyruvate + acetyl-CoA + H2O = CoA + H(+) + phosphinomethylmalate"}, {"i": "EC:2.3.3.18", "l": "\"2-phosphinomethylmalate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3296301", "l": "CCRL2 binds CCL19 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65847", "l": "ADP(out) + phosphate(in) <=> ADP(in) + phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41034", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + decanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-decanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944218", "l": "Association of procollagen type VIII (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0052601", "l": "(S)-limonene 1,2-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61180", "l": "quercetin + UDP-alpha-D-glucose = H(+) + quercetin 3-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.34", "l": "\"Neutrophil collagenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61668", "l": "ATP + CoA + salicylate = 2-hydroxybenzoyl-CoA + AMP + diphosphate"}, {"i": "EC:6.2.1.65", "l": "\"Salicylate--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46755", "l": "7alpha-hydroxycholest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56513", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O => 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23381", "l": "N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N,N'-diacetylchitobiosyl diphosphodolichol + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375302", "l": "Kinetochore capture of astral microtubules (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53362", "l": "H(+) + NADPH + uridine(47) in tRNA => 5,6-dihydrouridine(47) in tRNA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110468", "l": "Activation of DAkt1 by DPDK1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59241", "l": "L-arginine + L-lysine => L-homoarginine + L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618107", "l": "ATP binding to HSP90 triggers conformation change (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168412", "l": "MDP elicits a NOD2 response (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10069", "l": "4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose => 4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676596", "l": "TRAF3 binds BAFFR:BAFF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15636", "l": "3,4-dihydroxyphenylacetate + O2 <=> 2-hydroxy-5-carboxymethylmuconate semialdehyde + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928648", "l": "SFKs phosphorylate NGEF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5082356", "l": "HSF1-mediated gene expression (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671993", "l": "CIT-3 binds DLG4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26544", "l": "(R)-piperazine-2-carboxylate + NH4(+) => (R)-piperazine-2-carboxamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-500708", "l": "GRIK3 homomer binds glutamate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904928", "l": "coreceptor activity involved in canonical Wnt signaling pathway"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8858498", "l": "SL (surrogate light chain) binds IgH to form pre-BCR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807565", "l": "GNLY is transferred to the phagosome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35381", "l": "(8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA => (6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785594", "l": "FANCD2 binds FANCI (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23880", "l": "L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate"}, {"i": "EC:2.7.3.9", "l": "\"Phosphoenolpyruvate--protein phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630792", "l": "p16INK4A mutants do not bind CDK4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42866", "l": "H(+) + norspermine + S-methyl-5'-thioadenosine => norspermidine + S-adenosyl 3-(methylsulfanyl)propylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5444511", "l": "Formation of MSH2:MSH3 Complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50575", "l": "acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693540", "l": "MRN activates ATM (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781953", "l": "YOD1 binds VCP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651828", "l": "PARG dePARylates PARP1,PARP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-535717", "l": "Binding of calnexin/calreticulin to the unfolded protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374667", "l": "DCC interaction with SIAH2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39421", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+) => 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42456", "l": "4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol = 5alpha-cholesta-8,24-dien-3beta-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791060", "l": "Expression of SRPRB (SRP Receptor subunit beta) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625421", "l": "The anterograde IFT train dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017050", "l": "D-erythro-sphingosine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869568", "l": "NPM1 binds TFAP2A homodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.7.-.-", "l": "\"Carbon-phosphorus lyases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34864", "l": "2,3-didehydroadipyl-CoA + H2O => 3-hydroxyadipyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29214", "l": "H(+)(out) + inosine(in) <=> H(+)(in) + inosine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014454", "l": "RHOG translocates to the ER membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64955", "l": "dCDP + H2O <=> dCMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53326", "l": "2-glyceryl-prostaglandin E2 => 2-glyceryl-prostaglandin H2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52394", "l": "4-phospho-D-erythronate + ADP + H(+) => ATP + D-erythronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28955", "l": "D-glucuronate(in) + H(+)(in) = D-glucuronate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047228", "l": "1,2-diacylglycerol 3-glucosyltransferase activity"}, {"i": "MetaCyc:2.4.1.157-RXN"}, {"i": "EC:2.4.1.157"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033743", "l": "peptide-methionine (R)-S-oxide reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11273", "l": "a (2R)-2-hydroxycarboxylate + a quinone => a 2-oxocarboxylate + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170799", "l": "cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52949", "l": "deoxycholate + UDP-alpha-D-glucuronate => deoxycholoyl-24-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204600", "l": "Basigin homodimerises (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38400", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O => (9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004852", "l": "uroporphyrinogen-III synthase activity"}, {"i": "RHEA:18965", "l": "hydroxymethylbilane = H2O + uroporphyrinogen III"}, {"i": "EC:4.2.1.75", "l": "\"Uroporphyrinogen-III synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710101", "l": "CASP4, CASP5 cleave GSDMD (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867097", "l": "CD99 binds CD99L2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42897", "l": "L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950504", "l": "IL27 binds CRLF1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54245", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876789", "l": "CARNMT1 methylates CARN to Anserine (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40992", "l": "(E)-4-coumaroyl-CoA + H2O => 3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033196", "l": "tryparedoxin peroxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24770", "l": "chlorophyllide b + H(+) + NADH => 7(1)-hydroxychlorophyllide a + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24262", "l": "2-oxopent-4-enoate + CO2 => (3E)-2-oxohex-3-enedioate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36958", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + pentadecanoyl-CoA <=> (9Z)-pentadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25342", "l": "H2O + urea = carbamate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47119", "l": "eicosanoate + glycine <=> H2O + N-eicosanoylglycinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22001", "l": "D-xylose + NADP(+) => D-xylono-1,5-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429860", "l": "DCP1-DCP2 complex decaps mRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214398", "l": "Activated Phospho IRD5:KEY dimer phosphorylates REL in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33744", "l": "an N-acylsphing-4-enine 1-phosphate + H2O => an N-acylsphing-4-enine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43667", "l": "ATP + hydrogencarbonate + tetracosanoyl-CoA <=> 2-carboxytetracosanoyl-CoA + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26439", "l": "3-hydroxypropanoate + NADP(+) => 3-oxopropanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665748", "l": "FMNL2 binds RHOC:GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22267", "l": "3,5,6-trichloropyridin-2-ol + FADH2 + O2 <=> 3,6-dichloropyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20088", "l": "a flavonol 3-O-beta-D-glucoside + malonyl-CoA <=> a flavonol 3-O-(6-O-malonyl-beta-D-glucoside) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58954", "l": "(20S)-ginsenoside Rh1 + H(+) + UDP => (20S)-protopanaxatriol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22636", "l": "dCTP + H2O = dCMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15617", "l": "[Fe(II)cytochrome c] + Fe(3+) = [Fe(III)cytochrome c] + Fe(2+)"}, {"i": "EC:1.9.98.1", "l": "\"Iron--cytochrome-c reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15927", "l": "bunolol + H(+) + NADPH => dihydrobunolol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32177", "l": "alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+) => a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27465", "l": "ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP-D-glycero-beta-D-manno-heptose + diphosphate"}, {"i": "EC:2.7.7.70", "l": "\"D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42222", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850997", "l": "TRIM27 binds PTEN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35998", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45812", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O"}, {"i": "EC:4.2.1.134", "l": "\"Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983078", "l": "p-STAT3 dissociates from TSLP:IL7R:CRLF2:p-STAT3 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045158", "l": "electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.193"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204465", "l": "Basigin interacts with CD43 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170159", "l": "Translocation of Cdc25 to the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404131", "l": "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879594", "l": "SLCO4C1 mediates the transport of digoxin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625092", "l": "ABCA6 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50052", "l": "ATP + H2O + taurocholate(in) = ADP + H(+) + phosphate + taurocholate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44998", "l": "CoA + O-3-oxobutanoyl-(R)-carnitine => (R)-carnitine + acetoacetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.18", "l": "\"Lycopene epsilon-cyclase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26557", "l": "angiotensin II + H2O <=> angiotensin-(1-7) + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052726", "l": "inositol-1,3,4-trisphosphate 5-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2327733", "l": "FN1 binds Collagen types I-V, VII (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156930", "l": "GTP-binding activates eEF2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-937075", "l": "Phosphorylated TAK1 leaves activated TLR receptor complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48719", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate <=> 13-oxo-(9Z,11E)-octadecadienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111962", "l": "PDE4A,C,D hydrolyse cAMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29839", "l": "L-idonate + NADP(+) = 2-dehydro-L-idonate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55030", "l": "an N-methylornithine lipid + H(+) + S-adenosyl-L-homocysteine => an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693761", "l": "FA2H hydroxylates CERA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863858", "l": "SEC22B, CALR, STX4, TAP and TAPBP bind (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14859", "l": "ADP + H(+) + N(6)-[(indole-3-yl)acetyl]-L-lysine + phosphate => (indol-3-yl)acetate + ATP + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592278", "l": "Autocatalytic activation of proMMP2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35311", "l": "3-hydroxyisoheptadecanoyl-CoA + NADP(+) = 3-oxoisoheptadecanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034814", "l": "NTRK3 phosphorylates PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663265", "l": "NR1D1 (REV-ERBA) binds heme, the NR1D1 gene, and recruits corepressors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.1", "l": "\"Phosphodiesterase I\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24306", "l": "(R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2 => glycine + H(+) + N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.84", "l": "\"Limulus clotting factor C\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52747", "l": "cyclobis-(1->3)-alpha-isomaltosyl + H2O <=> alpha-isomaltosyl-(1->3)-isomaltose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55619", "l": "a carotenoid psi-end group <=> a carotenoid epsilon-end group"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985097", "l": "OAS2 dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186773", "l": "PDGF dimer binds two receptors simultaneously (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182198", "l": "Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-434989", "l": "SEMA7A binds to PLXNC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54076", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + stellata-2,6,19-triene"}, {"i": "EC:4.2.3.178", "l": "\"Stellata-2,6,19-triene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62104", "l": "(9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine = (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27447", "l": "D-xylose + H(+) + NADPH => NADP(+) + xylitol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047292", "l": "trihydroxypterocarpan dimethylallyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203973", "l": "Vesicle budding (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938231", "l": "RUNX1:CBFB binds CREBBP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5625421", "l": "The anterograde IFT train dissociates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706336", "l": "Active FLT3 binds to SYK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902052", "l": "(25S)-Delta(7)-dafachronate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62647", "l": "(5Z,8Z)-eicosadienoate + O2 <=> (5S)-hydroperoxy-(6E,8Z)-eicosadienoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052769", "l": "beta-6-sulfate-N-acetylglucosaminidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61322", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + parthenolide => (+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64482", "l": "(1S,3R,6R,8R,9R,11R,14S,15S,19R,20R)-8-ethyl-9,15-dihydroxy-3,4,6,20-tetramethyl-21,23-dioxo-24-azapentacyclo[20.2.1.0(1,6).0(11,20).0(14,19)]pentacosa-4,12,22(25)-trien-25-olate => 4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55139", "l": "ATP + D-alanine + H(+) <=> D-alanyl-5'-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802918", "l": "Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376419", "l": "Formation of NR-MED1 Coactivator Complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140675", "l": "ATP-dependent histone unloader activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11467", "l": "2 glutathione + L,L-homocystine <=> glutathione disulfide + 2 L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21499", "l": "dimethylallyl diphosphate + H2O <=> diphosphate + prenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349455", "l": "Phosphorylation of MDM4 by ATM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21495", "l": "2,3-dihydroxybenzoate + H(+) <=> catechol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16960", "l": "3',5'-cyclic GMP + H2O <=> GMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917987", "l": "TFRC dimer binds 2xholoTF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66390", "l": "ADP + H(+) + phosphate + prostaglandin E2(out) => ATP + H2O + prostaglandin E2(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70482", "l": "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209792", "l": "N-acetylation of serotonin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008043", "l": "MAPK8 phosphorylation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32312", "l": "L-tyrosine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61081", "l": "(+)-minovincinine + acetyl-CoA => (+)-echitovenine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782286", "l": "METTL1:WDR4 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0034290", "l": "holin activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2172678", "l": "PHF8 demethylates histone H4K20me1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951552", "l": "LTF:2xCO3(2-) dissociates from Carbocymycobactin:Fe3+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213248", "l": "Transport of antigen loaded MHC II molecules to surface (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2173317", "l": "C3a anaphylatoxin binds C3a receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62864", "l": "7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + S-adenosyl-L-methionine = 9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0046332", "l": "SMAD binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050307", "l": "sucrose-phosphate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19558", "l": "AH2 + O2 + pregna-4,9(11)-diene-3,20-dione => 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433456", "l": "Recruitment of STATs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.10", "l": "\"UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30133", "l": "H(+) + holo-[ACP] + octanoate => H2O + octanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15142", "l": "4-methylphenol + H2O + 4 oxidized [azurin] => 4-hydroxybenzaldehyde + 4 H(+) + 4 reduced [azurin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1015699", "l": "ISGF3 binds the ISRE promoter elements in IFN-stimulated genes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987039", "l": "JAK1 binds IL20RA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37257", "l": "2-oxosuccinamate + AH2 + NH4(+) => A + D-asparagine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58325", "l": "beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617864", "l": "HOXD4 mRNA is translated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57939", "l": "H2O + isopyridoxal + NAD(+) <=> 5-pyridoxate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730856", "l": "Autophosphorylation of PAK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66017", "l": "bromide + H2O2 => H2O + hypobromite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17534", "l": "2-oxoglutarate + an aromatic L-alpha-amino acid => an aromatic oxo-acid + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103111", "l": "D-glucosamine PTS permease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65522", "l": "all-trans-3-hydroxyretinol + H2O + 2 oxidized [adrenodoxin] => all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009040", "l": "ureidoglycolate dehydrogenase activity"}, {"i": "MetaCyc:R165-RXN"}, {"i": "EC:1.1.1.154", "l": "\"Ureidoglycolate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981539", "l": "C3b binds to cell surface (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20798", "l": "D-ribulose => aldehydo-D-ribose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050090", "l": "mannuronate reductase activity"}, {"i": "MetaCyc:MANNURONATE-REDUCTASE-RXN"}, {"i": "EC:1.1.1.131", "l": "\"Mannuronate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12362", "l": "13-(2-methylcrotonoyloxy)lupanine + CoA => (2E)-2-methylbut-2-enoyl-CoA + 13-hydroxylupanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209331", "l": "Formation of the 'scaffold complex' (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814096", "l": "ARL1:GTP binds SCOC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964580", "l": "The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds CCNA2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14579", "l": "crotonobetaine + H2O => (R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0050694", "l": "galactose 3-O-sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.48", "l": "\"15-oxoprostaglandin 13-reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19639", "l": "2-oxoglutarate + H(+) + L-arginine + NADPH => D-nopaline + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678920", "l": "TLR processing at low pH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26016", "l": "3-dehydroquinate => 3,7-dideoxy-D-threo-hepto-2,6-diuolosonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5223313", "l": "ABCD4:LMBRD1 transports Cbl from lysosomal lumen to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22758", "l": "a long-chain fatty aldehyde + H2O2 => a long-chain primary fatty alcohol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44286", "l": "4-hydroxy-6-heptylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + 2 malonyl-CoA + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33641", "l": "AMP + diphosphate + tetracosanoyl-CoA => ATP + CoA + tetracosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203070", "l": "Association of profilin with monomeric actin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35925", "l": "3''-deamino-3''-hydroxykanamycin B + H(+) + UDP => neamine + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9667965", "l": "ANKLE2 binds PP2A (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10947", "l": "H2O + psi-UMP <=> phosphate + pseudouridine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "72.270040348674314", "identifiers": [{"i": "GO:0015932", "l": "nucleobase-containing compound transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28160", "l": "alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20651", "l": "cucurbitacin B + H(+) + NADPH => 23,24-dihydrocucurbitacin B + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27332", "l": "H(+) + NADH + O2 + urate <=> 5-hydroxyisourate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4570493", "l": "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45135", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038191", "l": "neuropilin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43314", "l": "ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate => ATP + N-(hexanoyl)sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.13.-", "l": "\"Exoribonucleases producing 5'-phosphomonoesters\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55476", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + N-acyleicosasphinganine + O2 = 2 [Fe(III)-cytochrome b5] + H2O + N-acyl-4-hydroxyeicosasphinganine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0039706", "l": "co-receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210921", "l": "pagA binds ANTXR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693761", "l": "FA2H hydroxylates CERA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43158", "l": "H(+) + N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine => guanosine(9) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31398", "l": "15-cis-4,4'-diapophytoene + FAD + H(+) <=> all-trans-4,4'-diapophytofluene + FADH2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061811", "l": "ADP-ribosyl cyclase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "75.324974028080362", "identifiers": [{"i": "GO:0016875", "l": "ligase activity, forming carbon-oxygen bonds"}, {"i": "EC:6.1.-.-", "l": "\"Forming carbon-oxygen bonds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62879", "l": "AH2 + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate <=> A + semiviriditoxin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23758", "l": "dehydro-D-arabinono-1,4-lactone + H(+) + H2O2 => D-arabinono-1,4-lactone + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.128"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3797196", "l": "AP-1 transcription factor binds IGFBP7 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34615", "l": "2-hydroxyethylphosphonate + O2 = H(+) + hydrogencarbonate + methylphosphonate"}, {"i": "EC:1.13.11.73", "l": "\"Methylphosphonate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60632", "l": "all-trans-4-oxoretinol + NAD(+) = all-trans-4-oxoretinal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51122", "l": "(8S,15S)-dihydroxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 A + 2 H2O => (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48897", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide a => 3,8-divinyl protochlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66982", "l": "2-methylbutanoate + CoA + H(+) => 2-methylbutanoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18116", "l": "a ribonucleoside 5'-diphosphate + ATP <=> a ribonucleoside 5'-triphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37032", "l": "D-ribonate => 2-dehydro-3-deoxy-D-arabinonate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25398", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37040", "l": "5 AH2 + 2 H(+) + heme b + 4 O2 => 5 A + delta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005018", "l": "platelet-derived growth factor alpha-receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663124", "l": "p-BMAL1:p-CLOCK,NPAS2 binds SERPINE1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31179", "l": "(3S)-3-hydroxydodecanoyl-CoA + NAD(+) = 3-oxododecanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51232", "l": "2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin D2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023348", "l": "MECP2 binds DLL1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19892", "l": "alpha-D-glucose 1-phosphate + H(+) + UTP <=> diphosphate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187261", "l": "COLEC12 (SCARA4) binds ligands (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18514", "l": "D-mannitol + O2 => D-mannose + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080019", "l": "fatty-acyl-CoA reductase (alcohol-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.1"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047467", "l": "4-hydroxyphenylacetaldehyde-oxime isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799199", "l": "COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691131", "l": "CANDI binds CUL1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0070003", "l": "threonine-type peptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868134", "l": "CAST binds Ca2+ bound calpain (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42789", "l": "cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0004866", "l": "endopeptidase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9640195", "l": "RRAGA,B hydrolyzes GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59586", "l": "ADP + beta-alanyl-L-lysine + H(+) + phosphate => ATP + beta-alanine + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49960", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + H(+) + O2 = 5,10-dihydrophenazine + CO2 + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429101", "l": "HMIT co-transports myo-inositol with a proton (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24105", "l": "7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA => 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-164423", "l": "PhosphoChREBP (Thr 666)  is exported to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174255", "l": "Degradation multiubiquitinated Cyclin A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052730", "l": "sarcosine N-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868071", "l": "Clathrin recruits PIK3C2A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48255", "l": "ganglioside GD2 + UDP-alpha-D-galactose <=> ganglioside GD1b + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12343", "l": "L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] <=> H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59088", "l": "D-histidine + S-adenosyl-L-methionine = (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine"}, {"i": "EC:2.5.1.152", "l": "\"D-histidine 2-aminobutanoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852552", "l": "MST1R autophosphorylates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806957", "l": "MET receptor dimerizes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51149", "l": "a primary alcohol + 2 oxidized [azurin] => an aldehyde + 2 H(+) + 2 reduced [azurin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47237", "l": "eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051959", "l": "dynein light intermediate chain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948621", "l": "miR-20 microRNAs bind VAPA mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17294", "l": "2 H(+) + NADH + O2 + precorrin-3A => H2O + NAD(+) + precorrin-3B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23696", "l": "myo-inositol + O2 = D-glucuronate + H(+) + H2O"}, {"i": "EC:1.13.99.1", "l": "\"Inositol oxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "81.20444558259193", "identifiers": [{"i": "GO:0031821", "l": "G protein-coupled serotonin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202212", "l": "Recruitment of PLC-gamma1 to LAT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627350", "l": "SMAC (DIABLO) binds XIAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56767", "l": "12-epi-fischerindole U + 2-oxoglutarate + chloride + H(+) + O2 <=> 12-epi-fischerindole G + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32781", "l": "ADP + Co(2+)(in) + H(+) + phosphate => ATP + Co(2+)(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73718", "l": "UBF-1 Binds rDNA Promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23250", "l": "1D-4-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine => myo-inositol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55878", "l": "apo-[aequorin]--coelenterazine => apo-[aequorin] + coelenterazine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909726", "l": "Phosphorylation of STAT1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051566", "l": "anthocyanidin-3-glucoside rhamnosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19014", "l": "dTTP + H2O => dTDP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39720", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetracosanoate => 24-hydroxytetracosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9609921", "l": "SGTA binds Tail-anchored protein (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033608", "l": "formyl-CoA transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66674", "l": "5,7-dihydroxy-4-methylphthalide + H2O => 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65987", "l": "hnu + previtamin D3 <=> lumisterol 3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.4.-", "l": "\"With a disulfide as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34530", "l": "L-phenylalanine <=> (S)-3-amino-3-phenylpropanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60774", "l": "3 CO2 + gibberellin A9 + 2 H2O + 2 succinate => 2 2-oxoglutarate + gibberellin A12 + H(+) + 3 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708466", "l": "BACH1 translocates from the nucleoplasm to the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205112", "l": "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63815", "l": "ATP + N(8)-citryl-spermidine + spermidine <=> AMP + diphosphate + H(+) + N(8),N'(8)-citryl-bis(spermidine)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63069", "l": "acetyl-CoA + 2 H(+) + 2 malonyl-CoA => 2 CO2 + 3 CoA + triacetate lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975633", "l": "atROL binds to RBP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983142", "l": "Formation of peptide loading complex (PLC) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62034", "l": "a 2-acyl-sn-glycero-3-phosphoglycerol + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52623", "l": "3-methylbutanoyl-CoA <=> 2,2-dimethylpropanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52783", "l": "H2O + S-(hercyn-2-yl)-L-cysteine S-oxide <=> 2-sulfenohercynine + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.126"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210426", "l": "Glutamate synaptic vesicle docking and priming (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33670", "l": "H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine + NADPH + O2 <=> H2O + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52484", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + A = (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + AH2"}, {"i": "RHEA:55388", "l": "(3R)-3-hydroxy-2,3-dihydrotabersonine + A = (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2"}, {"i": "EC:1.1.99.41", "l": "\"3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299297", "l": "Activation of THIK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64920", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-983158", "l": "Trimming of peptides in ER (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15407", "l": "[(3R)-hydroxybutanoate](n+1) + CoA => (3R)-3-hydroxybutanoyl-CoA + [(3R)-hydroxybutanoate](n)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062124", "l": "4-hydroxybutyrate receptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052873", "l": "FMN reductase (NADPH) activity"}, {"i": "RHEA:21624", "l": "FMNH2 + NADP(+) = FMN + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10462", "l": "prostaglandin C1 => prostaglandin A1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52191", "l": "1-aci-nitro-2-(1H-indol-3-yl)ethane + glutathione <=> (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5666008", "l": "SCAI binds SRF:MKL1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12313", "l": "dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2 => 2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39086", "l": "3-oxododecanedioyl-CoA + CoA <=> acetyl-CoA + decanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20585", "l": "loganin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + secologanin"}, {"i": "EC:1.14.19.62", "l": "\"Secologanin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2731141", "l": "Syndecan-1 binds fibronectin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614614", "l": "Cysteine is degraded to serine and H2S (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605624", "l": "Beta-galactosidase hydrolyses GM1 to GM2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52037", "l": "H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate => L-isoleucine + tuberonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951951", "l": "RUNX3 binds EP300 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51646", "l": "cholesta-5,7-dien-3beta-ol + 2 H2O + NAD(+) => cholesterol + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44087", "l": "ATP + CoA + heptadecanoate <=> AMP + diphosphate + heptadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73577", "l": "CAD hexamer transforms L-Gln to CAP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170149", "l": "Translocation of active Cdc25C to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933525", "l": "Phosphorylation and release of IRF7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662597", "l": "MT1H binds cadmium (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617182", "l": "PRKACA phosphorylates PLN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42114", "l": "H(+) + NADPH + progesterone => (20S)-hydroxypregn-4-en-3-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64245", "l": "a fatty acyl-CoA + glycine => an N-(fatty acyl)-glycine + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044015", "l": "histone acetyltransferase activity (H2B-K12 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675790", "l": "MTORC1 dissociates from ULK complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57368", "l": "H2O + NADPH = (6R)-NADPHX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626276", "l": "HSP90 dissociates from LAMP2a (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42611", "l": "a plastoquinone + (n+1) H(+)(in) + NADH <=> a plastoquinol + n H(+)(out) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17535", "l": "an aromatic oxo-acid + L-glutamate => 2-oxoglutarate + an aromatic L-alpha-amino acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21493", "l": "2,3-dihydroxybenzoate + H(+) => catechol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39929", "l": "1-O-alkyl-sn-glycero-3-phosphate + choline + H(+) => 1-O-alkyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29692", "l": "alpha-maltotetraose + phosphate => alpha-D-glucose 1-phosphate + alpha-maltotriose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6786421", "l": "CHIA hydrolyses chitin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798474", "l": "S100A8:S100A9 binds Zn2+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001223", "l": "transcription coactivator binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13574", "l": "[(1->4)-alpha-D-galacturonosyl](n) + UDP-alpha-D-galacturonate => [(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004348", "l": "glucosylceramidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36394", "l": "cholesterol + NADP(+) <=> cholesta-5,24-dien-3beta-ol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27320", "l": "uracil(in) <=> uracil(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605768", "l": "Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47049", "l": "a quinone + shikimate => 3-dehydroshikimate + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39566", "l": "(2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H(+) + NADPH <=> (23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421833", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24700", "l": "7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + a 1,2-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1861788", "l": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.181", "l": "\"13-deoxydaunorubicin hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55712", "l": "(S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O = (9Z)-octadecenoate + (S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54627", "l": "2-oxoglutarate + O2 + octadecanoyl-CoA <=> 2-hydroxyoctadecanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46682", "l": "2 [Fe(II)-cytochrome b5] + H(+) + NAD(+) => 2 [Fe(III)-cytochrome b5] + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40722", "l": "an alkylcob(III)alamin + apo--[alkylcobalamin reductase] + glutathione <=> an S-substituted glutathione + cob(I)alamin--[alkylcobalamin reductase] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917841", "l": "Acidification of Tf:TfR1 containing endosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29066", "l": "a menaquinone + formate + H(+) <=> a menaquinol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37630", "l": "(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine <=> 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43137", "l": "guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60210", "l": "3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate => 3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44302", "l": "4-hydroxy-5-methyl-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + malonyl-CoA + methylmalonyl-CoA + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033883", "l": "pyridoxal phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605723", "l": "Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047162", "l": "17-O-deacetylvindoline O-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34950", "l": "(Z)-3-aminoacrylate + H(+) + H2O <=> 3-oxopropanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66586", "l": "25-hydroxy 3-oxocholestane + AH2 => 3-oxocholestane + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086083", "l": "SUMOylation of ING2 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49122", "l": "H2O + NADP(+) + violaceinate => H(+) + NADPH + O2 + protoviolaceinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53093", "l": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine => 2-hydroxy-3-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.18"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.21"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19385", "l": "UDP-alpha-D-glucose + vomilenine = H(+) + raucaffricine + UDP"}, {"i": "EC:2.4.1.219", "l": "\"Vomilenine glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69598", "l": "Ubiquitination of phosphorylated Cdc25A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45729", "l": "(E)-caffeyl alcohol + NADP(+) => (E)-caffeyl aldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43142", "l": "2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine => guanosine(26) in tRNA + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35231", "l": "rifampicin(in) = rifampicin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26271", "l": "Co(2+) + precorrin-2 => Co-precorrin-2 + 3 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-874079", "l": "AIM2 oligomerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34397", "l": "L-beta-phenylalanine => L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015143", "l": "urate transmembrane transporter activity"}, {"i": "REACT:R-HSA-5625210", "l": "Defective SLC22A12 does not exchange extracellular urate for cytosolic LACT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30567", "l": "5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate = 5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate"}, {"i": "EC:6.3.2.33", "l": "\"Tetrahydrosarcinapterin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877884", "l": "RUNX1 and FOXP3 stimulate the RSPO3 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852552", "l": "MST1R autophosphorylates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38520", "l": "1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 2-octadecanoylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38273", "l": "3-methylfumaryl-CoA + H2O => (3S)-citramalyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102838", "l": "1-18:1-2-16:2-monogalactosyldiacylglycerol desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48817", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 => 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45856", "l": "3-hydroxytetradecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(2-hydroxytridecyl)-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657642", "l": "ALKBH3 in complex with ASCC1:ASCC2:ASCC3 binds alkylated DNA containing 1-etA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52640", "l": "(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + octanoyl-CoA = (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507869", "l": "Aquaporins passively transport glycerol into cells (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8944457", "l": "MAF1 translocates to the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59290", "l": "D-glucose + sphing-4-enine => beta-D-glucosyl-(1<->1)-sphing-4-enine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877153", "l": "STARD7 binds PC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19416", "l": "ATP + L-phenylalanine + tRNA(Phe) <=> AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26084", "l": "(2E,6E)-farnesyl diphosphate <=> (Z)-gamma-bisabolene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380272", "l": "Plk1-mediated phosphorylation of Nlp (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909552", "l": "Phosphorylation of STAT1 at Ser727 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416530", "l": "FFAR1:FFAR1 ligands activates Gq (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173739", "l": "Spontaneous hydrolysis of C3 thioester (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168813", "l": "SOCS binding to JAK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60988", "l": "(E)-hex-2-en-1-ol + NAD(+) = (E)-hex--2-enal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54175", "l": "H2O + N(6)-acyl-L-lysyl-[protein] + NAD(+) <=> L-lysyl-[protein] + nicotinamide + O-acyl-ADP-D-ribose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693608", "l": "Initial resection of double-strand break ends (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11085", "l": "3-dehydro-L-gulonate + H(+) => CO2 + L-xylulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44287", "l": "2 H(+) + 2 malonyl-CoA + octanoyl-CoA <=> 4-hydroxy-6-heptylpyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56168", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33362", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54334", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40348", "l": "3-oxotetradecanedioyl-CoA + CoA => acetyl-CoA + dodecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4084505", "l": "Laminins bind HSPG2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3364026", "l": "SET1 complex trimethylates H3K4 at the MYC gene (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14827", "l": "(S)-carvone + H(+) + NADH => (1R,5S)-carveol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44839", "l": "globoside NORint (d18:1(4E)) + UDP-alpha-D-galactose <=> globoside NOR2 (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65373", "l": "CMP-N-acetyl-beta-neuraminate + globoside GalGb4Cer => CMP + globoside MSGG + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27933", "l": "(R)-4-phosphopantoate + ATP + beta-alanine <=> (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097246", "l": "catechin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6804099", "l": "HMGB1 binds LTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51998", "l": "a 1-(methylsulfanyl)-4-aci-nitroalkane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an (E)-omega-(methylsulfanyl)-alkanal oxime + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50097", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.34", "l": "\"Cathepsin E\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191303", "l": "FDPS dimer transfers IPPP to GPP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170149", "l": "Translocation of active Cdc25C to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25979", "l": "(+)-epi-isozizaene + H(+) + NADPH + O2 <=> (5S)-albaflavenol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698930", "l": "HCMV C Nucleocapsid Translocation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47898", "l": "6-deoxy-6-sulfo-D-glucono-1,5-lactone + H(+) + NADH => 6-sulfo-D-quinovose + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59462", "l": "H(+) + hexadecanal + NADPH => hexadecan-1-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66018", "l": "H2O + hypobromite => bromide + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47477", "l": "(3E)-tetradecenoyl-CoA => (2E)-tetradecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448673", "l": "Formation of caspase-1 p10/p20 dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690740", "l": "CD22 binds B-cell receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-874087", "l": "SGT1 binds HSP90 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14960", "l": "H(+) + NADH + O2 + tetradecanoyl-CoA <=> (11Z)-tetradecenoyl-CoA + 2 H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010348", "l": "lithium:proton antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17370", "l": "glycyrrhizin + H2O => 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627078", "l": "XIAP binds CASP9 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28960", "l": "D-xylose(in) + H(+)(in) => D-xylose(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9655086", "l": "ATF4 binds the DDIT3 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902121", "l": "lithocholic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419861", "l": "Melanospin is stimulated by light (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696358", "l": "TREM,CD300 binds lipids (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4332236", "l": "CBL neddylates TGFBR2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62791", "l": "2 fonsecin B + H(+) + NADPH + O2 <=> aurasperone B + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864577", "l": "TFAP2C translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56135", "l": "(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in DNA <=> a thymidine dimer in DNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41679", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + ATP <=> 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.-", "l": "\"With NADH or NADPH as one donor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40010", "l": "(+)-copalyl diphosphate + H2O <=> (+)-copalol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46202", "l": "5alpha-androstane-3beta,6alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5alpha-androstane-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44714", "l": "a 1-acylglycerol + a fatty acid + H(+) => a 1,2-diacylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60114", "l": "(E)-3-(indol-3-yl)acryloyl-CoA + H2O => (R)-3-(indol-3-yl)lactoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696131", "l": "AOC1 deaminates Hist (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66583", "l": "3'-phosphoadenylyl sulfate + bisphenol A <=> adenosine 3',5'-bisphosphate + bisphenyl A sulfate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56960", "l": "a ribonucleoside 5'-triphosphate + pyruvate = a ribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202947", "l": "Caspase mediated cleavage of APC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.34"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42538", "l": "pseudouridine(65) in tRNA => uridine(65) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68595", "l": "ORC2 binds ORC3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186785", "l": "PDGF-AA clevage by Furin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47064", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48379", "l": "a neolactoside nLc4Cer + GDP-beta-L-fucose <=> a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871227", "l": "RET binds GFRA4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874083", "l": "p-Y397-PTK2 binds SRC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047587", "l": "5-alpha-hydroxysteroid dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134883", "l": "Beta-catenin enhances association of IRF3 with CBP/p300  (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14165", "l": "acetyl-CoA + L-aspartate = CoA + H(+) + N-acetyl-L-aspartate"}, {"i": "EC:2.3.1.17", "l": "\"Aspartate N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814096", "l": "ARL1:GTP binds SCOC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-179410", "l": "Association of Nek2A with MCC:APC/C (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58558", "l": "(16S)-deshydroxymethyl-stemmadenine + formate => 15alpha-stemmadenine intermediate II + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61445", "l": "a tetracycline + H(+) + NADPH + O2 => an 11a-hydroxytetracycline + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23842", "l": "(2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+) => 3-(2,3-dihydroxyphenyl)propanoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674140", "l": "PAQR3 binds inactive RAFs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46084", "l": "H2O + sn-glycerol 1-phosphate = glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66368", "l": "6-methyl-3,7-dioxodecanedioyl-CoA + CoA = 4-methyl-5-oxo-octanedioyl-CoA + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351901", "l": "Caspase-mediated cleavage of MST3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24201", "l": "4-aminobenzoate + H(+) => aniline + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33453", "l": "AH2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] => A + H2O + N(6),N(6)-dimethyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20929", "l": "[DsbA protein]-dithiol + a quinone => [DsbA protein]-disulfide + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31638", "l": "beta-D-Delta(4)-GlcA-(1->4)-beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20464", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + 3 S-adenosyl-L-methionine <=> an N,N,N-trimethylornithine lipid + 3 H(+) + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19771", "l": "H2O + phaseollidin => phaseollidin hydrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37225", "l": "1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA => (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429714", "l": "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018572", "l": "EGFR phosphorylates NOTCH3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592235", "l": "Expression of POLG2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57891", "l": "a quinone + 5 H(+)(in) + NADH <=> a quinol + 4 H(+)(out) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14618", "l": "CoA + glutathione + NADP(+) => CoA-glutathione + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814298", "l": "Late envelope proteins bind cornified envelope:CDSN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975633", "l": "atROL binds to RBP2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38834", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62115", "l": "(3S)-3-hydroxy-D-aspartate <=> H2O + iminosuccinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51360", "l": "H2O + N-(9Z-octadecenoyl)-L-leucine = (9Z)-octadecenoate + L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32162", "l": "AH2 + epoxyqueuosine(34) in tRNA <=> A + H2O + queuosine(34) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40871", "l": "(9Z)-octadecenoyl-CoA + FAD + H(+) = (2E,9Z)-octadecadienoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9667914", "l": "ALK binds ligand midkine (MDK) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159194", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35308", "l": "H(+) + NADH + O2 + salicylate => 2,5-dihydroxybenzoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706354", "l": "Ubiquitination of FLT3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730903", "l": "Oligomerization of TRAF6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55145", "l": "[(3S,4R)-4-(6-methylheptanoyl)-5-oxooxolan-3-yl]methyl phosphate + NADP(+) => [4-(6-methylheptanoyl)-5-oxo-2H-furan-3-yl]methyl phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432121", "l": "LDL binds to LRP8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797810", "l": "PTPRD binds IL1RAPL1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41951", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate <=> [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52414", "l": "3-dehydro-4-O-phospho-D-erythronate + H(+) + NADH => 4-phospho-D-erythronate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43116", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + N-octanoylsphinganine + O2 = 2 [Fe(III)-cytochrome b5] + H2O + N-octanoyl-4-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42694", "l": "[(1->4)-alpha-D-glucosyl](n+2) + phosphate => [(1->4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56287", "l": "a (3R,4R)-4,2'-dihydroxyisoflavan + NADP(+) <=> a (3R)-2'-hydroxyisoflavanone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63339", "l": "alpha-D-xylose <=> beta-D-xylose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54058", "l": "(2E,6E)-hedycaryol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.44", "l": "\"Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176318", "l": "Loading of claspin onto DNA during replication origin firing (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50915", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-L-ribitol <=> 4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047075", "l": "2,5-dihydroxypyridine 5,6-dioxygenase activity"}, {"i": "RHEA:27522", "l": "2,5-dihydroxypyridine + O2 = H(+) + N-formylmaleamate"}, {"i": "EC:1.13.11.9", "l": "\"2,5-dihydroxypyridine 5,6-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1297275", "l": "CD9:Izumo Binding (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69142", "l": "Recruitment of Dna2 endonuclease (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048403", "l": "brain-derived neurotrophic factor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15459", "l": "catechol + H(+) + NADH => cis-1,2-dihydrobenzene-1,2-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592278", "l": "Autocatalytic activation of proMMP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17510", "l": "H2O + thiamine => 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62321", "l": "(+)-premalbrancheamide + chloride + FAD + 2 H(+) => (+)-isomalbrancheamide B + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857336", "l": "CEBPB homodimerization (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53338", "l": "H(+) + NADPH + uridine(20) in tRNA => 5,6-dihydrouridine(20) in tRNA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17201", "l": "2-dehydro-3-deoxy-L-arabinonate = 2,5-dioxopentanoate + H2O"}, {"i": "EC:4.2.1.43", "l": "\"2-dehydro-3-deoxy-L-arabinonate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36911", "l": "(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14516", "l": "ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine <=> ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12698", "l": "ATP + dGMP => ADP + dGDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49514", "l": "phosphinomethylisomalate => 2-(phosphinatomethylidene)butanedioate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41498", "l": "1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13850", "l": "D-arabinose => D-ribulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12187", "l": "(S,S)-butane-2,3-diol + NAD(+) <=> (S)-acetoin + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46868", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli) = a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24439", "l": "H2 + methanophenazine <=> dihydromethanophenazine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2106591", "l": "WWTR1:SMAD stimulates transcription of SMAD7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17955", "l": "(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde => 3-hydroxyanthranilate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110244", "l": "Excision of FapyG by OGG1 glycosylase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183052", "l": "CBL binds to GRB2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103015", "l": "4-amino-4-deoxy-L-arabinose transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64383", "l": "3 A + phytyl diphosphate <=> (2E,6E,10E)-geranylgeranyl diphosphate + 3 AH2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009486", "l": "cytochrome bo3 ubiquinol oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32559", "l": "(2E)-geranyl diphosphate = diphosphate + gamma-terpinene"}, {"i": "EC:4.2.3.114", "l": "\"Gamma-terpinene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13206", "l": "a monosaccharide 1-phosphate + H(+) + UTP => a UDP-monosaccharide + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202472", "l": "Translocation of TRAF6 to CBM complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848758", "l": "PTK6 phosphorylates AKT1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374673", "l": "L1 binds RanBPM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23641", "l": "1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 => CO2 + ethene + 2 H2O + hydrogen cyanide + L-dehydroascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.2.6", "l": "\"Leghemoglobin reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692781", "l": "p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341016", "l": "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371518", "l": "SIRT1 binds to HSF1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33361", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54977", "l": "(3S)-hydroxytetradecanoyl-CoA + H2O => (3S)-hydroxytetradecanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10002", "l": "NH4(+) + pentanoate => H2O + pentanamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43336", "l": "H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + n Na(+)(in) = CO2 + N(6)-biotinyl-L-lysyl-[protein] + n Na(+)(out)"}, {"i": "EC:7.2.4.1", "l": "\"Carboxybiotin decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23291", "l": "acetaldehyde + CoA + NAD(+) <=> acetyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.111", "l": "\"Aqualysin 1\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662620", "l": "MT3 binds cadmium (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13977", "l": "D-serine = NH4(+) + pyruvate"}, {"i": "EC:4.3.1.18", "l": "\"D-serine ammonia-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23989", "l": "(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate => (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42174", "l": "(8Z,11Z)-eicosadienoyl-CoA + A + 2 H2O => (11Z)-eicosenoyl-CoA + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30160", "l": "germacra-1(10),4,11(13)-trien-12-ol + NADP(+) => germacra-1(10),4,11(13)-trien-12-al + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030784", "l": "3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51117", "l": "guanosine(6) in tRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031729", "l": "CCR4 chemokine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876262", "l": "EPS15 and HGS bind CBL-monoubiquitinated MET engaged with Listeria InlB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847977", "l": "FRK phosphorylates PTEN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59268", "l": "A + H2O + N(6)-methyl-L-lysyl-[protein] = AH2 + formaldehyde + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102832", "l": "verbascose galactinol:ajugose galactosyltransferase activity"}, {"i": "MetaCyc:RXN-8288"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50343", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + testosterone <=> 1alpha-hydroxytestosterone + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036188", "l": "abieta-7,13-dien-18-al dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167601", "l": "Degradation of CD4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0090079", "l": "translation regulator activity, nucleic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11107", "l": "N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-methionine <=> H(+) + hercynine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033704", "l": "3beta-hydroxy-5alpha-steroid dehydrogenase activity"}, {"i": "KEGG.REACTION:R07138"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.4.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1671687", "l": "PRLR activation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20093", "l": "an anthocyanidin + H(+) + UDP-alpha-D-glucose = an anthocyanidin 3-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419490", "l": "Binding of ATP to P2X receptors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54874", "l": "(4S,7R)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+) => (1S,4R)-menthone + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0043865", "l": "methionine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38280", "l": "(3R)-citramalate + succinyl-CoA => (3R)-citramalyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45366", "l": "(11Z)-eicosenoate + (4R)-hydroxysphinganine => H2O + N-(11Z-eicosenoyl)-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56304", "l": "ATP + H2O + rifampicin = 21-phosphorifampicin + AMP + 2 H(+) + phosphate"}, {"i": "EC:2.7.9.6", "l": "\"Rifampicin phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034872", "l": "trans-geranyl-CoA isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50387", "l": "H(+) + oxidized coenzyme F420-(gamma-Glu)(n) + tetracycline <=> 5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229213", "l": "RCVRN:Ca2+ binds to and inhibits GRK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62445", "l": "L-canavanine + L-ornithine => H(+) + L-arginine + L-canaline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27498", "l": "3'-O-methyltricetin + S-adenosyl-L-methionine => 3',5'-di-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40476", "l": "1,2,3-tributanoylglycerol + H2O => butanoate + dibutanoylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004750", "l": "ribulose-phosphate 3-epimerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46448", "l": "2 L-tyrosyl-tRNA(Tyr) = cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr)"}, {"i": "EC:2.3.2.21", "l": "\"Cyclo(L-tyrosyl-L-tyrosyl) synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12786", "l": "an alditol + NAD(+) => an aldose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654167", "l": "Activated FGFR1 binds PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031718", "l": "type 1 cannabinoid receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1461982", "l": "Alpha-defensin dimers multimerize to form a pore complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54143", "l": "cytidine(49) in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine(49) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9690494", "l": "RHOB translocates to the endosome membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047054", "l": "berbamunine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34180", "l": "H2O + mycophenolic acid O-acyl-beta-D-glucuronide => D-glucuronate + H(+) + mycophenolate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62252", "l": "2 hydrogencarbonate(out) + Zn(2+)(out) = 2 hydrogencarbonate(in) + Zn(2+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19706", "l": "CoA + hexadecanal + NAD(+) => H(+) + hexadecanoyl-CoA + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950504", "l": "IL27 binds CRLF1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29437", "l": "enterobactin(out) + H(+)(in) => enterobactin(in) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37121", "l": "2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe) => 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654510", "l": "FGFRL1 binds SPRED1/2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47553", "l": "glycodeoxycholate + H2O => deoxycholate + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140506", "l": "endoplasmic reticulum-autophagosome adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41196", "l": "1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48624", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + O2 = (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950504", "l": "IL27 binds CRLF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382053", "l": "Translocation of PDGF from ER to Golgi (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39979", "l": "(+-)-pavine + S-adenosyl-L-methionine = H(+) + N-methylpavine + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.300", "l": "\"Pavine N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34371", "l": "H2O + indole-3-acetamide = (indol-3-yl)acetate + NH4(+)"}, {"i": "EC:3.5.1.4", "l": "\"Amidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59203", "l": "ATP + docosanoate + H(+) <=> diphosphate + docosanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733973", "l": "Bile salts bind FABP6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0005385", "l": "zinc ion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538835", "l": "PER binds to DCO (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24519", "l": "acetyl-CoA + gentamicin C1a <=> CoA + H(+) + N(2')-acetylgentamicin C1a"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.16", "l": "\"Ribulokinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031777", "l": "type 1 melanin-concentrating hormone receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45811", "l": "galactarate <=> (2S,3R)-dihydroxy-5-oxohexanedioate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781840", "l": "ERCC6 binds stalled RNA Pol II (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36645", "l": "H(+) + questin + S-adenosyl-L-homocysteine => emodin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56993", "l": "6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) => (+)-costunolide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389354", "l": "Activation of Vav1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55469", "l": "11-hydroxyferruginol + O2 + reduced [NADPH--hemoprotein reductase] => 11,20-dihydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42963", "l": "H(+) + NAD(+) + 2 reduced [nitric oxide reductase rubredoxin domain] <=> NADH + 2 oxidized [nitric oxide reductase rubredoxin domain]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47334", "l": "16alpha,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676591", "l": "2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64275", "l": "benzylamine + pyruvate <=> benzaldehyde + L-alanine"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0016664", "l": "oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor"}, {"i": "EC:1.7.7.-", "l": "\"With an iron-sulfur protein as acceptor\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102122", "l": "gibberellin A34 carboxyl methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49108", "l": "Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine = 3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + 2 H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940554", "l": "MMP2 cleaves OPTC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18416", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosaminyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28248", "l": "(R)-4-phosphopantoate + ADP + H(+) => (R)-pantoate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20975", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37744", "l": "dimethylallyl phosphate + FMNH2 => phosphate + prenyl-FMNH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63440", "l": "(2R)-3-phosphoglycerate + GTP + H(+) = 3-[(R)-glyceryl]-diphospho-5'-guanosine + diphosphate"}, {"i": "EC:2.7.7.106", "l": "\"3-phospho-D-glycerate guanylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52780", "l": "H2O + S-(hercyn-2-yl)-L-cysteine S-oxide = 2-sulfenohercynine + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43335", "l": "adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13315", "l": "formaldehyde + glycine + H2O2 => H2O + O2 + sarcosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12196", "l": "keto-D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O"}, {"i": "EC:4.1.2.22", "l": "\"Fructose-6-phosphate phosphoketolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45248", "l": "butanoate(out) = butanoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956234", "l": "Translation of DCUN1D3 is inhibited by PUM2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39302", "l": "(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015503", "l": "glutathione-regulated potassium exporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18868", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2-methylpropanoyl-CoA <=> (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[protein] + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12077", "l": "an aromatic primary alcohol + NAD(+) => an aromatic aldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22167", "l": "globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> globoside Forssman (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66238", "l": "H2O2 + IC-asc-DeltaC9-CoA => IC-asc-C9-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35915", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12353", "l": "L-gulono-1,4-lactone + O2 => H2O2 + L-xylo-hex-3-ulonolactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875591", "l": "DOCK7 activates RAC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210282", "l": "Interaction of GPVI and FceRI gamma (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050409", "l": "indolylacetylinositol arabinosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165028", "l": "Release of the HIV mRNA and Crm1 from Rev in the cytoplasm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9637638", "l": "esxA binds TLR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22390", "l": "CoA + N(6)-acetyl-N(6)-hydroxy-L-lysine => acetyl-CoA + N(6)-hydroxy-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951727", "l": "cAMP binds PKA tetramer (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36949", "l": "3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA => (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008828", "l": "dATP pyrophosphohydrolase activity"}, {"i": "REACT:R-HSA-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11965", "l": "5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O => 5alpha-cholestane-3beta,5,6beta-triol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60127", "l": "pre-sodorifen diphosphate <=> diphosphate + sodorifen"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0017089", "l": "glycolipid transfer activity"}, {"i": "REACT:R-HSA-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Homo sapiens)"}, {"i": "REACT:R-HSA-9697077", "l": "Rv1410c transports lprG:LM,LAM from cytosol to the cell wall (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50971", "l": "adenosine(37) in tRNA(Ala) + H(+) + H2O <=> inosine(37) in tRNA(Ala) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220966", "l": "NOTCH1 PEST domain mutants stimulate HES5 transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981621", "l": "Neuroglobin:oxygen dissociates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140080", "l": "class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004158", "l": "dihydroorotate oxidase activity"}, {"i": "RHEA:15441", "l": "(S)-dihydroorotate + O2 = H2O2 + orotate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34182", "l": "H2O + mycophenolic acid O-acyl-beta-D-glucuronide <=> D-glucuronate + H(+) + mycophenolate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856951", "l": "PP2A demethylation by PPME1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54586", "l": "an N(7)-methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine => a guanosine in 18S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17052", "l": "3-demethylubiquinol-9 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134822", "l": "DDX41 binds viral dsDNA  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35104", "l": "fusidate(in) => fusidate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14340", "l": "3'-phosphoadenylyl sulfate + UDP-N-acetyl-alpha-D-galactosamine 4-sulfate <=> adenosine 3',5'-bisphosphate + H(+) + UDP-N-acetyl-alpha-D-galactosamine 4,6-bissulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18573", "l": "dihydrochelirubine + H(+) + O2 = chelirubine + H2O2"}, {"i": "EC:1.5.3.12", "l": "\"Dihydrobenzophenanthridine oxidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009882", "l": "blue light photoreceptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16176", "l": "(4-hydroxyphenyl)acetaldehyde + dopamine <=> (S)-norcoclaurine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47697", "l": "(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + H2O => (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13745", "l": "ascopyrone M = microthecin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61846", "l": "H(+) + solasodine 3-beta-D-glucoside + UDP => solasodine + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944599", "l": "miR-93 microRNA binds PTEN mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43132", "l": "N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-methionine = H(+) + N(2)-dimethylguanosine(10) in tRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20930", "l": "[DsbA protein]-disulfide + a quinol => [DsbA protein]-dithiol + a quinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28159", "l": "alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate => alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0070735", "l": "protein-glycine ligase activity"}, {"i": "REACT:R-HSA-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444523", "l": "CXCR5 binds CXCL13 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30385", "l": "(-)-7-epi-alpha-selinene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10298", "l": "(2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH => D-glyceraldehyde 3-phosphate + NADP(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34912", "l": "D-methionine(in) => D-methionine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46503", "l": "2-oxoglutarate + O2 + UMP <=> CO2 + phosphate + succinate + uridine-5'-aldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24394", "l": "dTDP + H(+) + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate => dTDP-L-dihydrostreptose + streptidine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43936", "l": "androst-5-ene-3,17-dione = androst-4-ene-3,17-dione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49281", "l": "FADH2 + O2 + phenol => catechol + FAD + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710353", "l": "GSDMD (1-275) binds cardiolipin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061712", "l": "tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15511", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983144", "l": "Transport of Antigen peptide in to ER (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175108", "l": "Target DNA binding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450741", "l": "VANG, IN, FY, and FRTZ colocalise at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181152", "l": "Cleavage of NODAL proprotein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10233", "l": "5,6-dihydrouridine 5'-monophosphate + diphosphate => 5,6-dihydrouracil + 5-phospho-alpha-D-ribose 1-diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036204", "l": "abieta-7,13-dien-18-ol hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-873919", "l": "Phosphorylation of JAK2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60726", "l": "dodecanoate + 2 H(+) + NADPH => dodecanal + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58696", "l": "NADPH + O2 + rifampicin = H(+) + H2O + NADP(+) + rifampicin para-naphthoquinone carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5334827", "l": "SUMO-CRABP2 binds atRA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111970", "l": "PKC phosphorylates GRK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48716", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)-octadecadienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53777", "l": "3-sulfanylpropanoate + O2 => 3-sulfinopropanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39952", "l": "(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49111", "l": "Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine <=> 3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + 2 H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54039", "l": "[mycoredoxin]-L-cysteine + arseno-mycothiol + H(+) <=> [mycoredoxin]-S-mycothiol-L-cysteine + arsenite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32439", "l": "(+)-epi-isozizaene + 2 H(+) + 2 NADPH + 2 O2 = albaflavenone + 3 H2O + 2 NADP(+)"}, {"i": "EC:1.14.13.106", "l": "\"Epi-isozizaene 5-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45342", "l": "(9Z)-hexadecenoate + [Wnt protein]-L-serine + H(+) => [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186780", "l": "Degradation of Ub-SMAD7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12841", "l": "pyridoxamine + pyruvate = L-alanine + pyridoxal"}, {"i": "EC:2.6.1.30", "l": "\"Pyridoxamine--pyruvate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46371", "l": "2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (9Z,11E,13E)-octadecatrienoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52849", "l": "5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine => 5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102669", "l": "isoflavone-7-O-glucoside beta-glucosidase activity"}, {"i": "MetaCyc:RXN-3591"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38939", "l": "dioscin + 2 H2O = diosgenin 3-O-beta-D-glucoside + 2 L-rhamnopyranose"}, {"i": "EC:3.2.1.190", "l": "\"Dioscin glycosidase (3-O-beta-D-Glc-diosgenin-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166387", "l": "The FA anion diffuses away laterally from UCP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1454916", "l": "The ABCC family mediates organic anion transport (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008903", "l": "hydroxypyruvate isomerase activity"}, {"i": "RHEA:11952", "l": "3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate"}, {"i": "EC:5.3.1.22", "l": "\"Hydroxypyruvate isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610942", "l": "HCMV Formation of Final Envelopment Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176175", "l": "Stalling of DNA replication fork and RPA binding (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58208", "l": "A + dihydroalstonine = AH2 + alstonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58888", "l": "4-aminobenzoate + AH2 + 2 O2 = 4-nitrobenzoate + A + 2 H2O"}, {"i": "EC:1.14.99.68", "l": "\"4-aminobenzoate N-oxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0051018", "l": "protein kinase A binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32122", "l": "GDP-valienol + validamine 7-phosphate <=> GDP + H(+) + validoxylamine A 7'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44057", "l": "2-O-hexadecanoyl-alpha,alpha-trehalose + hexadecanoyl-CoA => 2-O,3-O-dihexadecanoyl-alpha,alpha-trehalose + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57517", "l": "dolabradiene + O2 + reduced [NADPH--hemoprotein reductase] => 15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12243", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH <=> 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53820", "l": "chenodeoxycholate + NADP(+) = 7-oxolithocholate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63358", "l": "(S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-thiazole-[protein] + H2O2 => (1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31425", "l": "(-)-alpha-cedrene + diphosphate => (2Z,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53869", "l": "2 H(+) + NADH + O2 + phenazine-1-carboxylate => 1-hydroxyphenazine + CO2 + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964619", "l": "PAK1 binds ARHGEF6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35944", "l": "brevianamide F + dimethylallyl diphosphate => deoxybrevianamide E + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027281", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-264615", "l": "Loading of acetylcholine in synaptic vesicles (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69140", "l": "RPA binds to the Flap (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38719", "l": "(R)-carnitine(out) + ATP + H2O = (R)-carnitine(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49223", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + CTP <=> CMP-beta-3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45761", "l": "dTDP-beta-L-daunosamine + epsilon-rhodomycinone => dTDP + H(+) + rhodomycin D"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63709", "l": "2 [Fe(II)-cytochrome b5] + a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl derivative + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl derivative + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676599", "l": "sBAFF trimer binds BAFFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61094", "l": "acetate + L-citrulline => H2O + N(2)-acetyl-L-citrulline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110319", "l": "Elongation by POLH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050205", "l": "oxamate carbamoyltransferase activity"}, {"i": "KEGG.REACTION:R02937"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16439", "l": "a halide anion + an S-substituted glutathione + H(+) => glutathione + RX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-420977", "l": "Ca permeable AMPA receptor ligand binding (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451309", "l": "Edited Kainate Receptor binds glutamate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635868", "l": "ub-GLI is degraded by the proteasome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.88", "l": "\"Repressor LexA\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35982", "l": "dimethylallyl diphosphate + verruculogen <=> diphosphate + fumitremorgin A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202164", "l": "Translocation of PDK1 to Plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051698", "l": "saccharopine oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65933", "l": "3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + S-adenosyl-L-methionine => 3,5-dimethyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804402", "l": "TP53 binds POU4F1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865107", "l": "MICAL1 produces NADP+, H2O2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034863", "l": "2,4,4-trimethyl-1-pentanol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33660", "l": "H(+) + N-tetracosanoylsphinganine + NADPH + O2 => H2O + N-(2-hydroxytetracosanoyl)-sphinganine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156661", "l": "Formation of Exon Junction Complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018667", "l": "cyclohexanone monooxygenase activity"}, {"i": "RHEA:24068", "l": "cyclohexanone + H(+) + NADPH + O2 = H2O + hexano-6-lactone + NADP(+)"}, {"i": "EC:1.14.13.22", "l": "\"Cyclohexanone monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22766", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53411", "l": "(1S,4R)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 <=> (4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41442", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate + CO2 + succinate => (2-aminoethyl)phosphonate + 2-oxoglutarate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18959", "l": "(1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17794", "l": "H2O + L-alanyl-tRNA(Thr) => H(+) + L-alanine + tRNA(Thr)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483186", "l": "PC is converted to PS by PTDSS1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26423", "l": "3'-phosphoadenylyl sulfate + thyroxine => adenosine 3',5'-bisphosphate + H(+) + thyroxine sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730860", "l": "Phosphorylation of GAB2 by SYK/FYN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047982", "l": "homocysteine desulfhydrase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48123", "l": "ganglioside GD3 + H2O <=> ganglioside GM3 + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132064", "l": "Antigen bound antibody interacts with C1complement complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49019", "l": "aurachin C epoxide <=> 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033871", "l": "[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111919", "l": "PKA phosphorylates CREB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44063", "l": "2-O-sulfo-alpha,alpha-trehalose + hexadecanoyl-CoA <=> 2-O-sulfo-2'-O-hexadecanoyl-alpha,alpha-trehalose + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864577", "l": "TFAP2C translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27848", "l": "(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+) => (2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2299620", "l": "Collagen XI cross-links with collagen II (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40662", "l": "1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol <=> 1-O-hexadecylglycerone 3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18040", "l": "agmatine + H2O <=> N-carbamoylputrescine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0036002", "l": "pre-mRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31180", "l": "(3S)-3-hydroxydodecanoyl-CoA + NAD(+) => 3-oxododecanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55851", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA <=> [(2->6)-alpha-D-glucosyl-(1->4)-N,7-O-diacetyl-alpha-D-neuraminosyl](n) + n CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189062", "l": "lactose + H2O => D-glucose + D-galactose (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19459", "l": "catechol + H2O + 2 NADP(+) + nitrite => 2-nitrophenol + 2 H(+) + 2 NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390438", "l": "FAR2 reduces PalmCoA to HXOL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58182", "l": "all-trans-lycopaoctaene + diphosphate + NADP(+) => (1R,2R,3R)-prephytoene diphosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57184", "l": "L-cysteinyl-[protein] + methylglyoxal = S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21806", "l": "1D-myo-inositol 3-phosphate + ADP + H(+) => ATP + myo-inositol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45786", "l": "3-phenylpropanoate + NH4(+) => 2 H2O + phenylpropanonitrile"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.54"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52146", "l": "(R)-2-(phosphonomethyl)malate + CoA + H(+) => 3-phosphonopyruvate + acetyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791071", "l": "Expression of PLA2G4B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51858", "l": "(2E)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (E)-hexadec-2-enoate(out) + ATP(in) + CoA(in) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53846", "l": "7-oxoglycolithocholate + H(+) + NADH => glycochenodeoxycholate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3640862", "l": "Tankyrase binds AXIN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41447", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate + O2 <=> glycine + 2 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22266", "l": "3,6-dichloropyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O => 3,5,6-trichloropyridin-2-ol + FADH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15506", "l": "2-(hydroxymethyl)glutarate + NAD(+) => 2-formylglutarate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785181", "l": "LMF1,2 bind LIPC dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034843", "l": "2-oxoglutaryl-CoA thioesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36745", "l": "CoA + H(+) + N-tetracosenoyl-heptadecasphing-4-enine => heptadecasphing-4-enine + tetracosenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0008138", "l": "protein tyrosine/serine/threonine phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102133", "l": "limonene hydroxylase activity"}, {"i": "MetaCyc:RXN-11493"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418200", "l": "SRC-1 bound to ARRB2 is not activated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29960", "l": "alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-galactose => alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878117", "l": "RUNX3 binds ZFHX3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31744", "l": "a 4'-hydroxyflavanone + S-adenosyl-L-methionine => a 4'-methoxyflavanone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40336", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034020", "l": "neoxanthin synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56226", "l": "3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP => 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950778", "l": "p-Y693-STAT4 dimerizes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14890", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate => (5Z,7E,9E,14Z,17Z)-icosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29542", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418925", "l": "ADORA2A,B bind Ade-Rib (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-68637", "l": "CDC6 protein is synthesized under the control of E2F transcription factors (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626938", "l": "Beta-catenin binds SOX proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64713", "l": "1-propanol + NADP(+) => H(+) + NADPH + propanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20346", "l": "[thioredoxin]-dithiol + NADP(+) => [thioredoxin]-disulfide + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38579", "l": "dammarenediol-II + O2 + reduced [NADPH--hemoprotein reductase] = (20S)-protopanaxadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.120", "l": "\"Dammarenediol 12-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-874087", "l": "SGT1 binds HSP90 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798129", "l": "TP53 binds the CASP6 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851298", "l": "GPR143 binds L-Dopa (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11101", "l": "4-hydroxyhexan-3-one => 2 propanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63553", "l": "angiotensin-(1-7) + H2O => angiotensin-(1-5) + L-histidyl-L-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20366", "l": "phosphoethanolamine + S-adenosyl-L-methionine => H(+) + N-methylethanolamine phosphate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41513", "l": "L-ornithine + NADH + O2 => H2O + N(5)-hydroxy-L-ornithine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352059", "l": "SLC6A15-mediated amino acid uptake (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944216", "l": "Association of procollagen type XV (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31633", "l": "phosphate + pseudaminate => 2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H2O + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9734730", "l": "ORC1 translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204549", "l": "Caveolin-1 binds Basigin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38271", "l": "(3S)-citramalyl-CoA = 3-methylfumaryl-CoA + H2O"}, {"i": "EC:4.2.1.153", "l": "\"3-methylfumaryl-CoA hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59410", "l": "acetate + L-aspartate => H2O + N-acetyl-L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854981", "l": "SHC1 in the RET complex is phosphorylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102114", "l": "caprate dehydroxylase activity"}, {"i": "MetaCyc:RXN-11325"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40626", "l": "H2O + tritetradecanoylglycerol <=> 2,3-ditetradecanoyl-sn-glycerol + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985201", "l": "ABCE1 binds RNASEL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785898", "l": "IL4R binds JAK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864595", "l": "TFAP2B homodimer binds YEATS4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24509", "l": "NADP(+) + prostaglandin F2alpha => H(+) + NADPH + prostaglandin E2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16230", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) => a CDP-1,2-diacyl-sn-glycerol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202466", "l": "Interaction of Bcl10 to CARMA1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62354", "l": "H2O + NADP(+) + notoamide D => H(+) + NADPH + notoamide E + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39651", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O = 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)"}, {"i": "EC:3.7.1.21", "l": "\"6-oxocyclohex-1-ene-1-carbonyl-CoA hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35972", "l": "12alpha,13alpha-dihydroxyfumitremorgin C + dimethylallyl diphosphate => diphosphate + fumitremorgin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265301", "l": "Corticotropin cleavage from POMC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3321805", "l": "NSL acetylates histone H4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41591", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40507", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46553", "l": "2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (9Z)-octadec-9-en-12-ynoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19211", "l": "codeinone + H(+) + NADPH => codeine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62657", "l": "2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + dimethylallyl diphosphate => 2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37017", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18690", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56028", "l": "3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = 3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39050", "l": "26-oxohexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + hexacosanedioate + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66482", "l": "gypsogenin 28-beta-D-glucoside + UDP => gypsogenin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210687", "l": "STAT92E transports from the nucleus to the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57420", "l": "NADH + 2 oxidized [cytochrome P450] = H(+) + NAD(+) + 2 reduced [cytochrome P450]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250463", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40469", "l": "(9Z)-octadecenoate + 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+) => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944362", "l": "TCF/LEF:CTNNB1 bind canonical WNT target promoters (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64735", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871227", "l": "RET binds GFRA4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40651", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31824", "l": "(2E,6E)-farnesyl diphosphate + H2O => cubebol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109342", "l": "Trans,cis-lauro-2,6-dienoyl-CoA is converted to cis,cis-3,6- 4-cis-decenoyl-CoA by one cycle of beta-oxidation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9667914", "l": "ALK binds ligand midkine (MDK) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994148", "l": "LRRC16A binds F-actin capping protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875558", "l": "RAPGEF1 binds CRK,CRKL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222411", "l": "Peroxynitrite oxidizes Peptide-Methionine residues (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28074", "l": "(2R)-3-sulfopropanediol + H2O + 2 NAD(+) = (R)-3-sulfolactate + 3 H(+) + 2 NADH"}, {"i": "EC:1.1.1.308", "l": "\"Sulfopropanediol 3-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8847880", "l": "CYTH proteins bind ARF1:GTP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507870", "l": "Aquaporins passively transport water out of cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51090", "l": "13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54092", "l": "3,4-dihydroxyphenylacetate + H(+) + NADPH + O2 = 2,4,5-trihydroxyphenylacetate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0015203", "l": "polyamine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37245", "l": "3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA => (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103074", "l": "glucose-6-phosphate 3-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090565", "l": "protein-phosphocysteine-mannitol phosphotransferase system transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55408", "l": "[phosphate](n) + CTP = [phosphate](n+1) + CDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33822", "l": "3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate <=> 3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30216", "l": "a menaquinol + 2 nitric oxide => a menaquinone + H2O + nitrous oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022141", "l": "Prolysyl oxidase activation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102099", "l": "FAD-dependent urate hydroxylase activity"}, {"i": "RHEA:27329", "l": "H(+) + NADH + O2 + urate = 5-hydroxyisourate + H2O + NAD(+)"}, {"i": "EC:1.14.13.113", "l": "\"FAD-dependent urate hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65639", "l": "sphinga-(4E,8E)-dienine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoylsphinga-(4E,8E)-dienine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.31"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53290", "l": "5-dehydro-L-gluconate + H(+) => 3-dehydro-scyllo-inosose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19962", "l": "a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate => a 2'-deoxyribonucleoside 5'-phosphate + a ribonucleoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955844", "l": "RBKS phosphorylates ribose to R5P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.6", "l": "\"AMP deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950365", "l": "Expression of S-methyl-5'-thioadenosine phosphorylase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419268", "l": "TUFM binds GTP displacing TSFM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217136", "l": "Phosphorylation of Chk1 by ATM upon DNA damage (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37797", "l": "2 H2O + 2 NADP(+) => 2 H(+) + 2 NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218805", "l": "PKC autophosphorylates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430096", "l": "GP1b-IX-V binds filamin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16790", "l": "a (2S)-2-hydroxycarboxylate + O2 => a 2-oxocarboxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24418", "l": "4-hydroxybenzoate + formate + 2 H(+) => 2,4'-dihydroxyacetophenone + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617672", "l": "HOXB3 gene is transcribed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174235", "l": "Association of Emi1 with Cdc20 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.307"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59852", "l": "(2S,3R)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH = (R)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427570", "l": "Group 3 - Selective Cl- transport (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003984", "l": "acetolactate synthase activity"}, {"i": "EC:2.2.1.6", "l": "\"Acetolactate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27328", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-dehydro-6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031217", "l": "glucan 1,4-beta-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111915", "l": "CAMK4 autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45370", "l": "(4R)-hydroxysphinganine + (9Z)-octadecenoate => H2O + N-(9Z-octadecenoyl)-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450466", "l": "AUF1:mRNA complex is destroyed (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2032770", "l": "Translocation of YAP1 to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13607", "l": "2 H2O + 2 L-dehydroascorbate => 2 L-ascorbate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25005", "l": "L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-984606", "l": "Kinesin-5 is a homotetramer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.338", "l": "\"Desmethylxanthohumol 6'-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237160", "l": "MTA is cleaved and phosphorylated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55131", "l": "(3R)-hydroxy-5-methylhexanoyl-[ACP] <=> (2E)-5-methylhexenoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.2.3"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140341", "l": "phosphatidylethanolamine floppase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034632", "l": "retinol transmembrane transporter activity"}, {"i": "REACT:R-HSA-2466802", "l": "Defective ABCA4 does not transport NRPE from disc membranes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11909", "l": "H2O + nonane-4,6-dione => butanoate + H(+) + pentan-2-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182986", "l": "CBL-mediated ubiquitination of CIN85 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66619", "l": "Mg(2+)(in) + 2 Na(+)(out) <=> Mg(2+)(out) + 2 Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199518", "l": "C3d-complexed antigen binds to complement receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12472", "l": "H2O + N-ethylglycine + O2 = ethylamine + glyoxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.15", "l": "\"Steroid sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.46"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36942", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + tetradecanoyl-CoA <=> (9Z)-tetradecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18065", "l": "ATP + H2O + phosphonate(out) = ADP + H(+) + phosphate + phosphonate(in)"}, {"i": "EC:7.3.2.2", "l": "\"ABC-type phosphonate transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-9635440", "l": "PapA5 transforms mycocerosyl to PDIM (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56134", "l": "a thymidine dimer in DNA => (5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in DNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28102", "l": "GDP-alpha-D-mannose + H2O = D-mannose + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36514", "l": "(9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA <=> (11Z)-3-oxoicosenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047574", "l": "4-acetamidobutyryl-CoA deacetylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689317", "l": "Formation of the pre-incision complex in GG-NER (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40484", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419049", "l": "ROCK activation by RHO (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48477", "l": "ganglioside GT1a (d18:1(4E)) + H2O => ganglioside GD1a (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24587", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H2O + NAD(+) <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33354", "l": "hexacosanoyl-CoA + sphinganine <=> CoA + H(+) + N-hexacosanoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62811", "l": "H(+) + 2 julichrome Q6 + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + julichrome Q6-6 + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33495", "l": "all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate = 3-heptaprenyl-sn-glycero-1-phosphate + diphosphate"}, {"i": "EC:2.5.1.n9", "l": "\"Heptaprenylglyceryl phosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607058", "l": "Activated protein C:PROCR binds F2R (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56176", "l": "8-demethyl-8-formylriboflavin 5'-phosphate + A + H2O = 8-carboxy-8-demethylriboflavin 5'-phosphate + AH2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004336", "l": "galactosylceramidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29536", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68603", "l": "ORC5 binds ORC2:ORC3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.30", "l": "\"Caricain\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49939", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983285", "l": "RAD51B binds RAD51C (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54984", "l": "a ubiquinol = a ubiquinone + 2 e(-) + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102892", "l": "betanidin 5-O-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-8479"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948066", "l": "K63polyUb-IRAK1 dissociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45632", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36940", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + tetradecanoyl-CoA => (9Z)-tetradecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38762", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018807", "l": "RAC3 GDIs block activation of RAC3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690701", "l": "SHP1 binds p-CD22 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249392", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987007", "l": "p-STAT1 dimerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111238", "l": "Formation of ADAR2  homodimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19526", "l": "(2E,6E)-farnesyl diphosphate => (1S,8aR)-delta-cadinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63028", "l": "(15Z)-tetracosenamide + H2O = (15Z)-tetracosenoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10862", "l": "2-(acetamidomethylene)succinate + NAD(+) => 3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37958", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> (8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209891", "l": "Dopamine is oxidised to noradrenaline (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58525", "l": "15alpha-stemmadenine intermediate I + H2O + NADPH => (16S)-deshydroxymethyl-stemmadenine + formate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27397", "l": "4'-demethylrebeccamycin + H2O = beta-D-glucose + dichloroarcyriaflavin A"}, {"i": "EC:4.3.3.5", "l": "\"4'-demethylrebeccamycin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.17"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51572", "l": "(25S)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25S)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791306", "l": "TP53 stimulates AIFM2 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42029", "l": "NAD(+) + ursodeoxycholate => 7-oxolithocholate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18385", "l": "acetone + 2 ATP + 3 H2O + hydrogencarbonate = acetoacetate + 2 AMP + 4 H(+) + 4 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870469", "l": "RGGT geranylgeranylates RAB proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62217", "l": "isoepoxydon + NADP(+) => H(+) + NADPH + phyllostine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42883", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermine <=> H(+) + N(4)-aminopropylspermine + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47087", "l": "4-methylsulfanyl-2-oxobutanoate + L-tyrosine <=> 3-(4-hydroxyphenyl)pyruvate + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10798", "l": "albendazole S-oxide + H2O + NADP(+) => albendazole + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102679", "l": "(5alpha)-campestan-3-one hydroxylase activity"}, {"i": "MetaCyc:RXN-4230"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65121", "l": "H2O + S-[(2E,6E,10E)-geranylgeranyl]-L-glutathione => L-glutamate + S-[(2E,6E,10E)-geranylgeranyl]-L-cysteinylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62901", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc + GDP-beta-L-fucose => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-GlcNAc + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43293", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45254", "l": "tetradecanoate(in) => tetradecanoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59188", "l": "L-histidine = D-histidine"}, {"i": "EC:5.1.1.24", "l": "\"Histidine racemase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41808", "l": "(3R)-hydroxybutanoyl-[ACP] = (2E)-butenoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64390", "l": "4 AH2 + sn-3-O-(geranylgeranyl)glycerol 1-phosphate => 4 A + sn-3-O-phytanylglycerol 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33209", "l": "ADP + L-glutamate 5-semialdehyde + NADP(+) + phosphate => ATP + H(+) + L-glutamate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55124", "l": "(2E)-5-methylhexenoyl-[ACP] + H(+) + NADH = 5-methylhexanoyl-[ACP] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37654", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404200", "l": "IGF1,2 binds IGF1R (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63141", "l": "H2O + N-tetracosanoyl-taurine => taurine + tetracosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786789", "l": "FLT3LG dimer binds FLT3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043532", "l": "angiostatin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33973", "l": "phosphate + ribostamycin => 5''-phosphoribostamycin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49204", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,24R-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33285", "l": "6-oxohexanoate + H2O + NADP(+) => 2-hydroxycyclohexan-1-one + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48148", "l": "ganglioside GT1b (d18:1(4E)/18:0) + H2O = ganglioside GD1b(d18:1(4E)/18:0) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3149539", "l": "MTR transfers CH3 group from MTHF to cob(I)alamin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53086", "l": "[(1->2)-beta-D-glucosyl](n+1) + H(+) + UDP => [(1->2)-beta-D-glucosyl](n) + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47713", "l": "trans-3-hydroxy-L-proline => cis-3-hydroxy-D-proline"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102476", "l": "pinocembrin 2-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32304", "l": "(2R)-homocitrate => (1R,2S)-homoisocitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34211", "l": "ecgonine methyl ester + NADP(+) = ecgonone methyl ester + H(+) + NADPH"}, {"i": "EC:1.1.1.334", "l": "\"Methylecgonone reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205319", "l": "Interaction of APS and p-KIT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20985", "l": "a sphingomyelin + H2O => an N-acylsphing-4-enine 1-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33763", "l": "a (2E)-enoyl-CoA + H(+) + NADPH = a 2,3-saturated acyl-CoA + NADP(+)"}, {"i": "EC:1.3.1.38", "l": "\"Trans-2-enoyl-CoA reductase (NADPH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45050", "l": "acetate + NH4(+) => acetamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46787", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(9Z,12Z,15Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047986", "l": "hydrogen-sulfide S-acetyltransferase activity"}, {"i": "MetaCyc:HYDROGEN-SULFIDE-S-ACETYLTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607744", "l": "MALT1 binds BCL10 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786501", "l": "TRMT11:TRMT112 methylates guanosine-10 in tRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65780", "l": "2 H(+) + metoxuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-(3-chloro-4-methoxylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050531", "l": "mannosyl-3-phosphoglycerate phosphatase activity"}, {"i": "MetaCyc:3.1.3.70-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340214", "l": "CYGB binds O2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.3.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689544", "l": "UCHL5 binds INO80 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57223", "l": "GTP + methylglyoxal <=> N(2)-(1-hydroxy-2-oxopropyl)-GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14437", "l": "H2O + L-lysine + O2 = 6-amino-2-oxohexanoate + H2O2 + NH4(+)"}, {"i": "EC:1.4.3.14", "l": "\"L-lysine oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12543", "l": "ATP + L-alanine + tRNA(Ala) <=> AMP + diphosphate + L-alanyl-tRNA(Ala)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13882", "l": "a quinone + an aldehyde + H2O => a carboxylate + a quinol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375138", "l": "CDO binds BOC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451033", "l": "(S)-Malate <=> Fumarate + H2O (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004408", "l": "holocytochrome-c synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38982", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17700", "l": "pyridine + thiamine <=> 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25995", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-epi-isozizaene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928577", "l": "ROCK phosphorylates LIMK1,2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987043", "l": "IL22RA1 binds JAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649671", "l": "NEIL1 recognizes and binds FapyA-dsDNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13435", "l": "2'-deoxyuridine + NH4(+) => 2'-deoxycytidine + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003864", "l": "3-methyl-2-oxobutanoate hydroxymethyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110153", "l": "RNA NAD-cap (NMN-forming) hydrolase activity"}, {"i": "RHEA:60876", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11411", "l": "H(+) + H2O + riboflavin <=> lumichrome + ribitol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55743", "l": "H2O + oleuropein <=> D-glucose + oleuropein aglycone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005251", "l": "delayed rectifier potassium channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24145", "l": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA => 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33925", "l": "[(1R)-2,2,3-trimethyl-2-oxocyclopent-3-en-1-yl]acetate + H(+) => (1R,4R)-5-oxo-1,2-campholide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52163", "l": "(E)-phenylacetaldehyde oxime <=> (Z)-phenylacetaldehyde oxime"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204863", "l": "Interaction of Tie2 with Ang2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222006", "l": "STK11 (LKB1) phosphorylates NUAK1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-947514", "l": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40755", "l": "(9Z,12Z)-octadecadienoate + 1-hexadecanoylglycerone 3-phosphate = 1-(9Z,12Z)-octadecadienoylglycerone 3-phosphate + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955706", "l": "TTL ligates L-Tyr to the carboxy terminus of detyr-alpha tubulin:beta tubulin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28018", "l": "enterobactin + 3 H2O = 2 H(+) + 3 N-(2,3-dihydroxybenzoyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36396", "l": "cholesta-5,7-dien-3beta-ol + NADP(+) => cholesta-5,7,24-trien-3beta-ol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53523", "l": "1-hexadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28863", "l": "H(+)(out) + lactose(in) = H(+)(in) + lactose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247836", "l": "Retromer recycles WLS to the Golgi (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33853", "l": "GDP + H(+) + mannosyl-alpha-1->6-inositol phospho-N-tetracosanoylsphinganine => GDP-alpha-D-mannose + N-tetracosanoylsphinganine-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50379", "l": "a ceramide(in) + ATP + H2O <=> a ceramide(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16902", "l": "acetyl-CoA + L-2,4-diaminobutanoate => (2S)-4-acetamido-2-aminobutanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607736", "l": "MALT1 oligomerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9611851", "l": "ADRB2 bind ADR,NAd (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-453342", "l": "PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54858", "l": "ethyl hexanoate + H2O + NADP(+) => H(+) + NADPH + O2 + octan-3-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10389", "l": "GTP + oxaloacetate => CO2 + GDP + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-349626", "l": "Integrin alpha2beta1 binds laminin-332 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37122", "l": "7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine <=> 2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193684", "l": "p62 recruits an atypical PKC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625426", "l": "Retrograde IFT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52339", "l": "a long-chain fatty acid + ATP + H(+) <=> a long-chain fatty acyl-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68954", "l": "Mcm2-7 is phosphorylated by DDK (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49969", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-376122", "l": "DSCAM/DSCAML1 homodimerization (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25047", "l": "(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O => (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937807", "l": "SRC phosphorylates RUNX3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159795", "l": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592436", "l": "Initial activation of proMMP9 by MMPs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981832", "l": "NMUR2 binds neuromedin-S (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610038", "l": "Defective GALT does not transfer UMP to Gal1P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55420", "l": "hexadecanoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5632668", "l": "SMO translocates to the cilium (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45903", "l": "a (3Z)-enoyl-CoA <=> a 4-saturated (2E)-enoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51157", "l": "ATP + L-glutamate + tRNA(Glu) => AMP + diphosphate + L-glutamyl-tRNA(Gln)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5578712", "l": "Importin-8 binds AGO2:miRNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160935", "l": "SMURF1 ubiquitinates RHOA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35545", "l": "3-hydroxypyruvate + phosphate => 3-phosphooxypyruvate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692779", "l": "p-S182 MAPKAPK5 phosphorylates FOXO1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8934742", "l": "RUNX1 binds PRMT1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65829", "l": "H2O + neryl diphosphate => diphosphate + nerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50582", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166041", "l": "Transfer of LPS onto TLR4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196753", "l": "2xPPCS ligates PPanK with Cys (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018502", "l": "2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102038", "l": "4-nitrobenzyl alcohol oxidase activity"}, {"i": "MetaCyc:R362-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46291", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0019113", "l": "limonene monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229152", "l": "MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592270", "l": "NID1 degradation by MMP1, 9, 12, ELANE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9010815", "l": "SLITs bind keratan sulfate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021523", "l": "WWP2 ubiquitinates NOTCH3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010113", "l": "ADAM10:Zn2+ binds TSPANs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427409", "l": "Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9678925", "l": "NR3C1 binds NR3C1 agonists (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40909", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 2-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1606602", "l": "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15804", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212356", "l": "Formation of CSL-NICD coactivator complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10714", "l": "2-phenylacetamide + CO2 + H2O => L-phenylalanine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16975", "l": "2,5-dihydroxypyridine + A + H2O => 2-hydroxypyridine + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625375", "l": "FOXO3,FOXO4 bind STK11 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050487", "l": "sulfoacetaldehyde acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0009784", "l": "transmembrane receptor histidine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60166", "l": "an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine => a guanosine in RNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39957", "l": "(9Z)-octadecenoate + glycerol + H(+) => (9Z-octadecenoyl)-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19348", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate <=> (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72672", "l": "The 60S subunit joins the translation initiation complex  (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018450", "l": "myrtenol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15034", "l": "O2 + pyridoxine => H2O2 + pyridoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936941", "l": "Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30435", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + glycyl-tRNA(Gly) = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + tRNA(Gly)"}, {"i": "EC:2.3.2.16", "l": "\"Lipid II:glycine glycyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693783", "l": "NAALADases hydrolyse NAAG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11763", "l": "4 ATP + citrate + 2 H2O + 2 N(6)-acetyl-N(6)-hydroxy-L-lysine <=> 4 ADP + aerobactin + 4 H(+) + 4 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389756", "l": "AKT interacts and phosphorylates Cot (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17620", "l": "leukotriene C4 <=> glutathione + leukotriene A4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45461", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a fatty acid + H(+) + N,1-diacyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25739", "l": "N-hydroxy-L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30818", "l": "beta-nicotinamide D-ribonucleotide + H2O <=> beta-nicotinamide D-riboside + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196773", "l": "COASY phosphorylates DP-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392834", "l": "Activation of EPACs by cAMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44213", "l": "3-hydroxytetradecanoate + ATP + CoA => 3-hydroxytetradecanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0048028", "l": "galacturonan binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44496", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylethanolamine = 2-(acylamino)ethyl fatty acid + a monoacyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18743", "l": "10-deacetylbaccatin III + CoA => 10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29001", "l": "H(+)(in) + homoserine lactone(out) => H(+)(out) + homoserine lactone(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007625", "l": "RBBP8 gene expression is inhibited by E2F6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37641", "l": "1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21837", "l": "D-arabinonate => 2-dehydro-3-deoxy-D-arabinonate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49320", "l": "all-trans-violaxanthin = (5R,6S)-5,6-epoxi-capsanthin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641206", "l": "RSPOs bind LGRs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-997237", "l": "SH2B proteins bind JAK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031803", "l": "Maresin-like SPMs translocate from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.95"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51603", "l": "2 H(+) + m-xylene + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2317530", "l": "SREBP1A,1C,2 binds SCAP:cholesterol:INSIG and is retained in the endoplasmic reticulum (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451347", "l": "Activation of JNK by DSCAM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19160", "l": "D-xylonate <=> 2-dehydro-3-deoxy-D-arabinonate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29173", "l": "a ubiquinone + 2 H(+) + 2 superoxide => a ubiquinol + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14554", "l": "(7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate => 2-oxoglutarate + cephalosporin C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088134", "l": "PLK1 phosphorylates FOXM1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53912", "l": "butanoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-butanoyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5263633", "l": "DYSF, CAV3 and TRIM72 bind (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4647593", "l": "EP400 binds CDKN1A promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "81.790986234327661", "identifiers": [{"i": "GO:0050308", "l": "sugar-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937034", "l": "IRAK1 phosphorylates Pellino (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11154", "l": "2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+) => 5-pyridoxate + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.6", "l": "\"Tubulin GTPase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2468040", "l": "Cohesin binds PDS5 and WAPAL (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868236", "l": "BAR domain proteins recruit dynamin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38779", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-622415", "l": "RIP2 binds NEMO (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41760", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM3 (d18:1(4E)) = CMP + ganglioside GD3 (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21150", "l": "5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP => indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19845", "l": "nocardicin E + S-adenosyl-L-methionine = H(+) + isonocardicin A + S-methyl-5'-thioadenosine"}, {"i": "RHEA:49708", "l": "nocardicin G + S-adenosyl-L-methionine = H(+) + isonocardicin C + S-methyl-5'-thioadenosine"}, {"i": "EC:2.5.1.38", "l": "\"Isonocardicin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60516", "l": "L-tryptophan = D-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944246", "l": "Association of procollagen type XXI (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61819", "l": "16,17-didehydropregnenolone + UDP-alpha-D-glucose <=> 16,17-didehydropregnenolone 3-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65757", "l": "2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] => (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-419003", "l": "Interaction of Nectins with Afadin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20913", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + taxa-4,11-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180573", "l": "Degradation of ubiquitinated CD4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50487", "l": "acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163568", "l": "phosphorylated perilipin + H2O -> perilipin + orthophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33385", "l": "(S)-malyl N-acetyl-alpha-D-glucosaminide + H(+) + UDP => (S)-malate + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64811", "l": "acetyl-CoA + O-(2-aminoethyl)-L-serine <=> CoA + H(+) + O-(2-acetamidoethyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549129", "l": "OCT1 transports organic cations into hepatic cells (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030599", "l": "pectinesterase activity"}, {"i": "RHEA:22380", "l": "[(1->4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1->4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol"}, {"i": "EC:3.1.1.11", "l": "\"Pectinesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21540", "l": "N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate"}, {"i": "EC:5.3.1.24", "l": "\"Phosphoribosylanthranilate isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950674", "l": "IL27 translocates from the cytosol to the extracellular space (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72621", "l": "Ribosomal scanning  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0008933", "l": "lytic transglycosylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209081", "l": "Disassembly of the destabilised 'destruction complex' (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13724", "l": "H2O + testololactone <=> H(+) + testolate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21615", "l": "D-gluconate <=> 2-dehydro-3-deoxy-D-gluconate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60121", "l": "(2E,6E)-farnesyl diphosphate + S-adenosyl-L-methionine => H(+) + pre-sodorifen diphosphate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983424", "l": "Budding of COPII coated vesicle (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58571", "l": "15alpha-stemmadenine + acetyl-CoA <=> CoA + O-acetyl-15alpha-stemmadenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050002", "l": "D-proline reductase (dithiol) activity"}, {"i": "RHEA:12737", "l": "5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine = [PrdC protein]-L-selenocysteine/L-cysteine + D-proline"}, {"i": "EC:1.21.4.1", "l": "\"D-proline reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.37", "l": "\"FAD reductase (NADH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46265", "l": "2 [Fe(II)-cytochrome b5] + an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56078", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+) => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63920", "l": "octadecanoyl-CoA + sphinga-4E,14Z-dienine = CoA + H(+) + N-octadecanoyl-sphinga-4E,14Z-dienine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66582", "l": "adenosine 3',5'-bisphosphate + bisphenyl A sulfate + H(+) => 3'-phosphoadenylyl sulfate + bisphenol A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72127", "l": "Formation of the Spliceosomal B Complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44206", "l": "2-hydroxyhexadecanoyl-CoA + AMP + diphosphate => 2-hydroxyhexadecanoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41301", "l": "(9Z)-octadecenoate + sphing-4-enine => H2O + N-(9Z-octadecenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65449", "l": "butanoyl-CoA + ethanol => CoA + ethyl butanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16532", "l": "ADP + H(+) + sulfate <=> adenosine 5'-phosphosulfate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592436", "l": "Initial activation of proMMP9 by MMPs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36080", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine => a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57973", "l": "8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39844", "l": "1,3-diacyl-sn-glycerol + an acyl-CoA => a triacyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15879", "l": "D-glutamate + pyridoxal 5'-phosphate => 2-oxoglutarate + pyridoxamine 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17480", "l": "precorrin-6B + 2 S-adenosyl-L-methionine <=> CO2 + 3 H(+) + precorrin-8X + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39890", "l": "2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pikromycin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202164", "l": "Translocation of PDK1 to Plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672817", "l": "Active MTORC1 binds the ULK1 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673296", "l": "WNT5:FZD7 binds p-DVL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0019212", "l": "phosphatase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445700", "l": "Myosin Binds ATP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950344", "l": "Expression of BolA-like protein 2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876789", "l": "CARNMT1 methylates CARN to Anserine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683792", "l": "p-T68-CHEK2 autophosphorylates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645598", "l": "RRAGC,D hydrolyzes GTP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58628", "l": "FADH2-C4alpha-hydroperoxide + H(+) + NADPH + rifamycin SV = FADH2 + H2O + NADP(+) + rifamycin SV hemiaminal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166726", "l": "Activation of MASPs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427337", "l": "MBD2 binds methylcytosine in chromatin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24728", "l": "H(+) + indolmycin + S-adenosyl-L-homocysteine => N-demethylindolmycin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791096", "l": "Expression of PPP2R5B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.19", "l": "\"ADP-dependent medium-chain-acyl-CoA hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987007", "l": "p-STAT1 dimerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0140161", "l": "monocarboxylate:sodium symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54844", "l": "H(+) + hexan-3-one + NADPH + O2 = ethyl butanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183051", "l": "CBL ubiquitinates Sprouty (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008241", "l": "peptidyl-dipeptidase activity"}, {"i": "EC:3.4.15.-", "l": "\"Peptidyl-dipeptidases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56504", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202394", "l": "Translocation of CARMA1 to Plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10682", "l": "D-proline => L-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66854", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate => (2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047747", "l": "cholate-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030294", "l": "receptor signaling protein tyrosine kinase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20727", "l": "a 4-saturated-(3S)-3-hydroxyacyl-CoA <=> a (3E)-enoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0001217", "l": "DNA-binding transcription repressor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62656", "l": "2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + dimethylallyl diphosphate = 2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5578712", "l": "Importin-8 binds AGO2:miRNA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40487", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14646", "l": "H2O + S-adenosyl-L-methionine => H(+) + L-homoserine + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990162", "l": "histone deacetylase activity (H3-K4 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47195", "l": "[methyl-Co(III) methylated-thiol-specific corrinoid protein] + coenzyme M <=> [Co(I) methylated-thiol-specific corrinoid protein] + H(+) + methyl-coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928645", "l": "EPHB:NMDAR binds TIAM1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362551", "l": "Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938356", "l": "RMB14 binds RUNX2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13657", "l": "acetyl-[citrate lyase ACP] + H2O = acetate + H(+) + holo-[citrate lyase ACP]"}, {"i": "EC:3.1.2.16", "l": "\"Citrate-lyase deacetylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190141", "l": "ALAD binds to Pb2+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5675790", "l": "MTORC1 dissociates from ULK complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805546", "l": "Keratin type I binds keratin type II (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43271", "l": "ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GM2 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46819", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029680", "l": "Caspase-7 translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3245898", "l": "TCN1 binds Cbl in the circulation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371590", "l": "HSP70 binds to HSP40:nascent protein (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59292", "l": "beta-D-galactosyl-(1<->1')-N-octadecanoylsphing-4-enine + H2O = D-galactose + N-octadecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674015", "l": "Olaratumab binds PDGFRA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33997", "l": "5-oxo-L-proline + butirosin B => gamma-L-glutamyl-butirosin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5333051", "l": "RPA1 binds HSF1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31634", "l": "2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H2O + phosphoenolpyruvate <=> phosphate + pseudaminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690669", "l": "CD22 binds itself to form homo-oligomers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63338", "l": "beta-D-xylose => alpha-D-xylose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380170", "l": "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51684", "l": "(2E,6E)-farnesyl phosphate + CTP = (2E,6E)-farnesyl diphosphate + CDP"}, {"i": "EC:2.7.4.32", "l": "\"Farnesyl phosphate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199203", "l": "PANK1/3/4 phosphorylate PanK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-350901", "l": "Iodide is organified (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "76.412572999466406", "identifiers": [{"i": "GO:0016796", "l": "exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters"}, {"i": "EC:3.1.15.-", "l": "\"Exonucleases active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1299318", "l": "Activation of TASK (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61341", "l": "(S)-methylmalonyl-CoA + H(+) => CO2 + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670888", "l": "F9 variant is not secreted (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033732", "l": "pyrroloquinoline-quinone synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019137", "l": "thioglucosidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015578", "l": "mannose transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371518", "l": "SIRT1 binds to HSF1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0004376", "l": "glycolipid mannosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-990489", "l": "Kinesin-13 is a dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605632", "l": "Both hexosaminidase A and B can cleave GalNAc from globoside (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28218", "l": "chloride + H(+) + H2O2 = H2O + hypochlorous acid"}, {"i": "EC:1.11.2.2", "l": "\"Myeloperoxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432121", "l": "LDL binds to LRP8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371385", "l": "TNF-alpha is cleaved by ADAM17 (TACE) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416516", "l": "GRK2 sequesters activated Gq (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37477", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9626817", "l": "PKC phosphorylates NCF1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16691", "l": "D-glucose + phosphate => D-glucose 6-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58070", "l": "acetaldehyde + vanillin => O2 + trans-isoeugenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41751", "l": "3'-phosphoadenylyl sulfate + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol <=> 1,2-diacyl-3-(3-O-sulfo-beta-D-galactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39830", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + tetracosanoate <=> 2-hydroxytetracosanoate + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192061", "l": "CYP46A1 24-hydroxylates CHOL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.4", "l": "\"Ribonuclease H\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44377", "l": "a 1-acyl-sn-glycero-3-phosphocholine(in) => a 1-acyl-sn-glycero-3-phosphocholine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52461", "l": "17beta-estradiol + UDP-alpha-D-glucuronate => 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63611", "l": "apelin-17 + H2O <=> apelin-16 + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22214", "l": "(2R,3S)-tartrate => (2R,3R)-tartrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27725", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-4-deoxy-4-formamido-beta-L-arabinose <=> 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19028", "l": "H2O + L-aspartate + O2 <=> H2O2 + NH4(+) + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446391", "l": "Formation of the PINCH-ILK-parvin complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932284", "l": "PKC phosphorylates NFE2L2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-377644", "l": "Release of CSK from SRC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482629", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6810376", "l": "ING2 binds PI5P (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35284", "l": "(9Z)-octadecenoyl-CoA => (2E)-octadecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018766", "l": "RHOU binds effectors at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37105", "l": "(N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683925", "l": "ULK1 is dephosphorylated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63236", "l": "ATP + streptomycin = 6-O-adenylylstreptomycin + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013024", "l": "RHOB binds effectors at the plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210439", "l": "glutamate uptake by astrocytes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52561", "l": "2-dehydro-D-erythronate => 3-dehydro-D-erythronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42572", "l": "3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+) = 2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46685", "l": "3-oxochol-4-en-24-oyl-CoA + A => (22E)-3-oxo-chol-4,22-dien-24-oyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5679239", "l": "ULK complex translocates to the ER (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9617595", "l": "SGTA binds mislocalized membrane protein (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13477", "l": "H2O + L-tryptophan + NADP(+) = H(+) + indole-3-pyruvate + NADPH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27364", "l": "chloride + S-adenosyl-L-methionine <=> chloromethane + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168445", "l": "PTP1B binds the GH receptor complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177942", "l": "EGFR binds EGF ligand (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.237", "l": "\"Hydroxyphenylpyruvate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26496", "l": "7-chloro-L-tryptophan + FAD + 2 H2O => chloride + FADH2 + L-tryptophan + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43803", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26512", "l": "L-proline + NH4(+) => H2O + L-prolinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617446", "l": "HOXD1 mRNA is translated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32236", "l": "(6S)-NADPHX + ADP => AMP + H(+) + NADPH + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30779", "l": "D-gluconate + FAD + H(+) = 2-dehydro-D-gluconate + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58909", "l": "7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH => C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047858", "l": "dihydroxyfumarate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15565", "l": "an N-acyl-L-amino acid + H2O = a carboxylate + an L-alpha-amino acid"}, {"i": "EC:3.5.1.14", "l": "\"N-acyl-aliphatic-L-amino acid amidohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43814", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1,2-dioctadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786650", "l": "DDHD1,2 hydrolyse PA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42406", "l": "beta-D-glucose + D-galactose 6-phosphate => H2O + lactose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19742", "l": "formyl-CoA + H2O => CoA + formate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17888", "l": "acetaldehyde <=> acetylene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-606349", "l": "Mis18 complex binds the centromere (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683964", "l": "ATM phosphorylates EYA1-4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51011", "l": "2 [Fe(III)cytochrome cL] + methanol <=> 2 [Fe(II)cytochrome cL] + formaldehyde + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25486", "l": "(1S,4R)-camphene + diphosphate => (2E)-geranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112037", "l": "Inactivation of PLC beta (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45413", "l": "H2O + prostaglandin D2-1-glycerol ester => glycerol + H(+) + prostaglandin D2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0031072", "l": "heat shock protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65631", "l": "sphinga-(4E,8Z)-dienine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoylsphinga-(4E,8Z)-dienine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27417", "l": "2 [Fe(III)cytochrome] + H2O + nicotinate = 6-hydroxynicotinate + 2 [Fe(II)cytochrome] + 2 H(+)"}, {"i": "EC:1.17.2.1", "l": "\"Nicotinate dehydrogenase (cytochrome)\""}]}
{"type": "biolink:MolecularActivity", "ic": "64.27530379215159", "identifiers": [{"i": "GO:0008514", "l": "organic anion transmembrane transporter activity"}, {"i": "REACT:R-HSA-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4086132", "l": "Dentin phosphoprotein binds integrin alphaVbeta1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013438", "l": "RHOD binds effectors at the endosome membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46136", "l": "aminopyrrolnitrin + H(+) + NADPH + 2 O2 = 2 H2O + NADP(+) + pyrrolnitrin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420975", "l": "Ca impermeable AMPA receptor ligand binding (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986294", "l": "RUNX2 binds GLI2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38031", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) = (2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228411", "l": "Clathrin-mediated endocytosis of tetX HC:LC:gangliosides (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36663", "l": "(S)-1-pyrroline-5-carboxylate + H(+) + H2O + malonyl-CoA = (2S,5S)-5-carboxymethylproline + CO2 + CoA"}, {"i": "EC:2.3.1.226", "l": "\"Carboxymethylproline synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447130", "l": "Interleukin-23 binds interleukin-23 receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.33"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31170", "l": "(3S)-hydroxytetradecanoyl-CoA + NAD(+) <=> 3-oxotetradecanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052655", "l": "L-valine transaminase activity"}, {"i": "KEGG.REACTION:R01214"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804242", "l": "TP53 binds the complex of JMY, EP300 and TTC5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45052", "l": "(2E)-butenoyl-CoA + (R)-carnitine = CoA + O-(2E)-butenoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5252133", "l": "ATP6AP1 binds V-ATPase (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "60.150591168707123", "identifiers": [{"i": "GO:0008757", "l": "S-adenosylmethionine-dependent methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20437", "l": "5D-5-O-methyl-chiro-inositol + NADP(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH"}, {"i": "EC:1.1.1.142", "l": "\"D-pinitol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19133", "l": "2-oxoglutarate + 3,3',5-triiodo-L-thyronine = 3,5,3'-triiodothyropyruvate + L-glutamate"}, {"i": "EC:2.6.1.26", "l": "\"Thyroid-hormone transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009700", "l": "IL2RB and IL2RG are phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788867", "l": "FN3K phosphorylates ketosamines (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66310", "l": "an alpha-mannosylinositol-1-phosphoceramide + GDP + H(+) => an inositol-1-phosphoceramide + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33773", "l": "1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + CMP + H(+) => a 1,2-diacyl-sn-glycerol + CDP-N-methylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8873946", "l": "OTUD3 deubiquitinates PTEN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37222", "l": "A + D-valine + H2O <=> 3-methyl-2-oxobutanoate + AH2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60192", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689972", "l": "USP2 deubiquitinates MDM2,MDM4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66402", "l": "ADP + glutathione(out) + glycocholate(out) + H(+) + phosphate => ATP + glutathione(in) + glycocholate(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57317", "l": "ATP + cytidine 5'-diphosphoramidate => ADP + cytidine 3'-phospho-5'-diphosphoramidate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16073", "l": "2,2-dialkylglycine + H(+) + pyruvate = CO2 + dialkyl ketone + L-alanine"}, {"i": "EC:4.1.1.64", "l": "\"2,2-dialkylglycine decarboxylase (pyruvate)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51633", "l": "all-trans-(4S)-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-(4S,16)-dihydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937419", "l": "CBR3 reduces DOX to DOXOL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48246", "l": "CMP + ganglioside GM1b + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-912627", "l": "CBL ubiquitinates PI3K (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877153", "l": "STARD7 binds PC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11751", "l": "fluoroacetaldehyde + L-threonine <=> 4-fluoro-L-threonine + acetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66237", "l": "IC-asc-C9-CoA + O2 => H2O2 + IC-asc-DeltaC9-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21575", "l": "3-hydroxy-2-methyl-1H-quinolin-4-one + O2 <=> CO + H(+) + N-acetylanthranilate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30002", "l": "ATP + H2O + spermidine(out) <=> ADP + H(+) + phosphate + spermidine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689544", "l": "UCHL5 binds INO80 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168272", "l": "Binding of the influenza virion to the host cell (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674019", "l": "BRAP binds KSR1:MARK3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130194", "l": "ABL phosphorylates WAVEs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730892", "l": "Recruitment of VAV to p-SLP-76 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625416", "l": "Anterograde IFT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849646", "l": "SPINK5(490-624) binds KLK5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30786", "l": "D-glyceraldehyde + H2O + NAD(+) <=> (R)-glycerate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38962", "l": "a 2,3-saturated acyl-CoA + O2 <=> a (2E)-enoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57027", "l": "apulose 4-phosphate + D-glyceraldehyde 3-phosphate <=> D-xylulose 5-phosphate + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54090", "l": "2,4,5-trihydroxyphenylacetate + H2O + NAD(+) => 3,4-dihydroxyphenylacetate + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44548", "l": "an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an (omega-1)-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35055", "l": "3,6-dichlorocatechol + O2 = (2E,4E)-2,5-dichloromuconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031750", "l": "D3 dopamine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218806", "l": "FYN autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38310", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203567", "l": "palmitoylation of eNOS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937820", "l": "SRC,YES1 bind YAP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804741", "l": "MDM2 forms homo- or heterodimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49922", "l": "(R)-carnitine(in) + O-octanoyl-(R)-carnitine(out) => (R)-carnitine(out) + O-octanoyl-(R)-carnitine(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047840", "l": "dCTP diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19839", "l": "beta-D-fructose 6-phosphate + H(+) + NADH => D-sorbitol 6-phosphate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928646", "l": "EPHAs bind EFNAs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.110"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57555", "l": "[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + O2 + reduced [NADPH--hemoprotein reductase] <=> (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9649733", "l": "mature p21 RAS binds GDP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4332356", "l": "CAMK2 binds MAP3K7 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21090", "l": "a flavonol + CO2 + H2O + succinate => 2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070287", "l": "ferritin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2976563", "l": "NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21761", "l": "(3S)-3-hydroxybutanoyl-CoA => (3R)-3-hydroxybutanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12918", "l": "3alpha(S)-strictosidine + H2O => D-glucose + strictosidine aglycone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66656", "l": "Cu(2+)(out) + L-ascorbate(in) = Cu(+)(out) + H(+) + monodehydro-L-ascorbate radical(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008120", "l": "ceramide glucosyltransferase activity"}, {"i": "MetaCyc:CERAMIDE-GLUCOSYLTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28265", "l": "3-alpha-D-mannopyranosyl-alpha-D-mannopyranose + UDP-alpha-D-xylose <=> 3-O-(6-O-alpha-D-xylosylphospho-alpha-D-mannopyranosyl)-alpha-D-mannopyranose + H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.14"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034348", "l": "type III interferon receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570528", "l": "SUMOylation of XPC with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381496", "l": "Formation of the IGF:IGFBP3:ALS complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169192", "l": "PTP1B dephosphorylates GHR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211904", "l": "CYP4F12 18-hydroxylates ARA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865244", "l": "TFAP2A homodimer binds CDKN1A (p21) gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28338", "l": "(R)-carnitinyl-CoA = crotonobetainyl-CoA + H2O"}, {"i": "EC:4.2.1.149", "l": "\"Crotonobetainyl-CoA hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64665", "l": "a long-chain fatty acyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] => a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132100", "l": "Fluid-phase proteolytic cleavage of factor B (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23507", "l": "adenosylcob(III)inamide + H2O <=> (R)-1-aminopropan-2-ol + adenosylcob(III)yrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3204303", "l": "MRE11 binds cytosolic DNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21070", "l": "AH2 + nitrate => A + H2O + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10360", "l": "3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl)propanoate + H(+)"}, {"i": "EC:3.1.1.35", "l": "\"Dihydrocoumarin hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27486", "l": "allantoate + 2 H(+) + H2O => (S)-2-ureidoglycine + CO2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869694", "l": "oxPL binds CD14 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54311", "l": "pseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38481", "l": "H(+) + N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-homocysteine => N(alpha)-methyl-L-histidine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16813", "l": "H2O + L-kynurenine = anthranilate + H(+) + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40934", "l": "2-oxoglutarate + L-ornithine + O2 <=> (3S)-3-hydroxy-L-ornithine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20271", "l": "2 5-dehydro-4-deoxy-D-glucuronate => 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16703", "l": "estrone + H(+) + NADH => 17alpha-estradiol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20444", "l": "L-cysteine + O2 <=> 3-sulfino-L-alanine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40961", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51067", "l": "3'-phosphoadenylyl sulfate + lithocholate <=> adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428625", "l": "Vesicular inhibitory amino acid transport (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9660557", "l": "RAS:GTP binds RAL GDS proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42566", "l": "pseudouridine(38/39) in tRNA => uridine(38/39) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322429", "l": "XIAP monoubiquinates TLE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24146", "l": "3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O => 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382061", "l": "Extracellular processing of novel PDGFs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57136", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphoserine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40358", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + ATP <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043795", "l": "glyceraldehyde oxidoreductase activity"}, {"i": "RHEA:36047", "l": "A + D-glyceraldehyde + H2O = (R)-glycerate + AH2 + H(+)"}, {"i": "EC:1.2.99.8", "l": "\"Glyceraldehyde dehydrogenase (FAD-containing)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045551", "l": "cinnamyl-alcohol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18262", "l": "H2O + precorrin-5 + S-adenosyl-L-methionine => acetate + 2 H(+) + precorrin-6A + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61154", "l": "CoA + myricetin 3-O-[(6-O-(E)-caffeoyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside] => (E)-caffeoyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28203", "l": "2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate => 2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0008192", "l": "RNA guanylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990309", "l": "type-II dockerin domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51364", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = CoA + H(+) + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380316", "l": "Association of NuMA with microtubules (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62102", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35337", "l": "3-oxoisoheptadecanoyl-CoA + CO2 + CoA => H(+) + isopentadecanoyl-CoA + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5615604", "l": "Defective POMT1 does not transfer Man from Dol-P-Man to DAG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388832", "l": "PI3K binds CD28 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51451", "l": "chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] <=> alpha-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72722", "l": "eIF2 activation (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9706393", "l": "RHOBTB3 binds ATP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53878", "l": "ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate => a cytidine in tRNA + acetyl-CoA + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61625", "l": "2-oxoglutarate + cadaverine => 5-aminopentanal + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19796", "l": "H(+) + H2O + oxidized [electron-transfer flavoprotein] + sarcosine <=> formaldehyde + glycine + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444476", "l": "FPRL2 receptor binds a wide range of ligands (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013023", "l": "RHOB GEFs activate RHOB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018794", "l": "RHOV binds effectors at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392834", "l": "Activation of EPACs by cAMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62411", "l": "3,3'-di-O-methyl-4alpha-mannobiose + S-adenosyl-L-methionine <=> 1,3,3'-tri-O-methyl-4alpha-mannobiose + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140696", "l": "factor V -> factor Va + factor V activation peptide (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392064", "l": "G alpha (z) inhibits adenylate cyclase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9679775", "l": "COMT binds COMT Inhibitors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35180", "l": "6 H(+) + hexanoyl-[ACP] + 7 malonyl-CoA => 7 CO2 + 7 CoA + 2 H2O + holo-[ACP] + noranthrone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53744", "l": "glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60009", "l": "a tRNA precursor + 2 CTP => a tRNA with a 3' CC end + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375160", "l": "NCAM1 binds to ATP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23739", "l": "5-hydroxyisourate + H2O <=> 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007606", "l": "E2F6 binds BRCA1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55951", "l": "A + D-alanine + H2O <=> AH2 + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54047", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> 7-epi-alpha-eudesmol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-947535", "l": "Cyclisation of GTP to precursor Z (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60055", "l": "a 3beta-hydroxy-4,4-dimethylsteroid + H(+) + NADH + O2 <=> a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23550", "l": "H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(966) in 16S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602624", "l": "Defective TRAF3 does not transmit the signal (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607721", "l": "Activation of NIK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295632", "l": "PPA2A dephosphorylates SPRY2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37000", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871366", "l": "p-Y281,292-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21039", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373730", "l": "Neurofascin and NrCAM heterodimerization (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10912", "l": "(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)"}, {"i": "EC:6.3.2.1", "l": "\"Pantoate--beta-alanine ligase (AMP-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59618", "l": "beta-alanine + L-arginine => beta-alanyl-L-arginine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56219", "l": "O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51247", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50197", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-981621", "l": "C3 convertases spontaneously dissociate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13458", "l": "3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N(6)-lipoyl-L-lysine + H(+) => [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51006", "l": "2 [Fe(II)cytochrome cL] + an aldehyde + 2 H(+) => 2 [Fe(III)cytochrome cL] + a primary alcohol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66669", "l": "5-methylorsellinate + O2 + reduced [NADPH--hemoprotein reductase] => 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56402", "l": "(3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+) => [(3R)-hydroxybutanoate](n) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21927", "l": "3-dehydro-L-gulonate + NAD(+) <=> 2,3-dioxo-L-gulonate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17862", "l": "21-hydroxyprogesterone => 20-hydroxy-3-oxopregn-4-en-21-al"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10605", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35738", "l": "a (2R)-2-hydroxycarboxylate + NADP(+) <=> a 2-oxocarboxylate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445704", "l": "Calcium Binds Caldesmon (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20499", "l": "CoA + H(+) + N-acetyl-2-arylethylamine => 2-arylethylamine + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022872", "l": "MECP2 binds MOBP gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164521", "l": "Insertion of gp41 fusion peptide into the target membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050467", "l": "pentalenene synthase activity"}, {"i": "RHEA:18081", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + pentalenene"}, {"i": "EC:4.2.3.7", "l": "\"Pentalenene synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018845", "l": "2-hydroxychromene-2-carboxylate isomerase activity"}, {"i": "KEGG.REACTION:R05137"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610760", "l": "GLI1 is degraded by the proteasome after ubiquitination by ITCH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42195", "l": "(9Z)-pentadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-pentadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030771", "l": "N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39165", "l": "(3R)-hydroxyhexadecanoyl-CoA + NADP(+) => 3-oxohexadecanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420977", "l": "Ca permeable AMPA receptor ligand binding (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38967", "l": "an N-acylsphing-4-enine(in) + ATP + H2O = ADP + an N-acylsphing-4-enine(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66272", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45027", "l": "cholesterol + H(+) + NADPH + O2 <=> cholesta-5,7-dien-3beta-ol + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938773", "l": "RNF144A polyubiquitinates PRKDC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351871", "l": "Caspase-mediated cleavage of Z0-2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032935", "l": "sterol sensor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55841", "l": "calcidiol + UDP-alpha-D-glucuronate => calcidiol 25-O-(beta-D-glucuronide) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15273", "l": "2-oxoglutarate + L-dopa = 3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate"}, {"i": "EC:2.6.1.49", "l": "\"Dihydroxyphenylalanine transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42484", "l": "D-sorbitol(out) + N(pros)-phospho-L-histidyl-[protein] = D-sorbitol 6-phosphate(in) + L-histidyl-[protein]"}, {"i": "EC:2.7.1.198", "l": "\"Protein-N(pi)-phosphohistidine--D-sorbitol phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12831", "l": "mesaconate + NH4(+) => (2S,3S)-3-methyl-L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0052890", "l": "oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor"}, {"i": "EC:1.3.8.-", "l": "\"With a flavin as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "77.02358060617253", "identifiers": [{"i": "GO:0015491", "l": "cation:cation antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60326", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983158", "l": "Trimming of peptides in ER (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51393", "l": "(9Z)-octadecenoyl-CoA + serotonin => CoA + H(+) + N-(9Z-octadecenoyl)-serotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49181", "l": "a bacteriochlorophyllide d + S-adenosyl-L-methionine => a bacteriochlorophyllide c + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794344", "l": "HOMER binds SHANK proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.22", "l": "\"Vitamin D 1,25-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60361", "l": "FMN + H(+) + oxidized coenzyme F420-0 => dehydro coenzyme F420-0 + FMNH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11426", "l": "ADP + H(+) + O-phospho-L-threonyl-[myosin heavy-chain] => ATP + L-threonyl-[myosin heavy-chain]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050897", "l": "cobalt ion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5252072", "l": "AZGP1 binds PIP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11290", "l": "H2O2 + macarpine => dihydromacarpine + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444476", "l": "FPRL2 receptor binds a wide range of ligands (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936951", "l": "Activation of TAK1 complex bound to activated TLR4 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17996", "l": "ATP + beta-alanine + L-gamma-glutamyl-L-cysteine <=> ADP + gamma-L-glutamyl-L-cysteinyl-beta-alanine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60340", "l": "N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45097", "l": "(9Z)-hexadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-hexadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404131", "l": "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022396", "l": "MME:Zn2+ hydrolyses AGT(34-43) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16332", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19357", "l": "H(+) + L-proline betaine + NADPH + O2 = formaldehyde + H2O + N-methyl-L-proline + NADP(+)"}, {"i": "RHEA:61616", "l": "H(+) + L-proline betaine + NADH + O2 = formaldehyde + H2O + N-methyl-L-proline + NAD(+)"}, {"i": "EC:1.14.13.247", "l": "\"Stachydrine N-demethylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112396", "l": "Separation of elongating transcript from template (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13474", "l": "H2O + L-tryptophan + NAD(+) => H(+) + indole-3-pyruvate + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16272", "l": "aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP(+) <=> 4-(dimethylamino)azobenzene + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48977", "l": "5-methyl-phenazine-1-carboxylate + 2 H(+) + NADH + O2 => CO2 + H2O + NAD(+) + pyocyanin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193665", "l": "MYD88 dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31111", "l": "acetyl-CoA + butanoyl-CoA = 3-oxohexanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33899", "l": "FAD + H(+) + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose = FADH2 + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose"}, {"i": "EC:1.1.98.3", "l": "\"Decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676229", "l": "WIPIs bind PI3P (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033716", "l": "nucleoside oxidase (hydrogen peroxide-forming) activity"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004128", "l": "cytochrome-b5 reductase activity, acting on NAD(P)H"}, {"i": "RHEA:46680", "l": "2 [Fe(III)-cytochrome b5] + NADH = 2 [Fe(II)-cytochrome b5] + H(+) + NAD(+)"}, {"i": "EC:1.6.2.2", "l": "\"Cytochrome-b5 reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61384", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351948", "l": "Mitochondrial recruitment of Drp1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0032357", "l": "oxidized purine DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28014", "l": "S-adenosyl-L-methionine + thiocyanate = methyl thiocyanate + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.n4", "l": "\"Thiocyanate methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57903", "l": "2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2 <=> adenosine in U6 snRNA + CO2 + formaldehyde + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033895", "l": "ribonuclease [poly-(U)-specific] activity"}, {"i": "EC:3.1.26.9", "l": "\"Ribonuclease (poly-(U)-specific)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59981", "l": "8-oxo-dGTP + H2O => 8-oxo-dGDP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-171059", "l": "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28625", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + solavetivol => (-)-vetispiradiene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59545", "l": "N,N'-diacetylchitobiose + O2 => H2O2 + N,N'-diacetylchitobiono-1,5-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734730", "l": "ORC1 translocates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65700", "l": "chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] = cholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196964", "l": "RFK:Mg2+ phosphorylates RIB (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41730", "l": "18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40903", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22257", "l": "a (3R)-3-hydroxyacyl-CoA + NADP(+) => a 3-oxoacyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060002", "l": "plus-end directed microfilament motor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080004", "l": "thalian-diol desaturase activity"}, {"i": "MetaCyc:RXN-9637"}, {"i": "EC:1.14.21.-", "l": "\"With NADH or NADPH as one donor, and the other dehydrogenated\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38590", "l": "UDP-alpha-D-glucose + vancomycin aglycone <=> devancoaminyl-vancomycin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782881", "l": "LCMT2 methylates yW-72 yielding yW-58 at nucleotide 37 of tRNA(Phe) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34730", "l": "H2O + N-acyl-15-methylhexadecasphinganine <=> 15-methylhexadecasphinganine + a carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33654", "l": "(9Z,12Z)-octadecadienoate + ATP + CoA <=> (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37732", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine => 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56266", "l": "CMP + H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.24.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033568", "l": "lactoferrin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44395", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA <=> 1-heptadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50271", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate <=> (5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018774", "l": "RHOBTB1 binds GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449087", "l": "CD4 binds Interleukin-16 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691150", "l": "TFR2 dimer binds 2xholoTF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019862", "l": "IgA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9727349", "l": "XDH dehydrogenates xanthine to form urate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030487", "l": "inositol-4,5-bisphosphate 5-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097655", "l": "serpin family protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13702", "l": "acetyl-CoA + L-homoserine => CoA + O-acetyl-L-homoserine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811412", "l": "Active ARF recruits coatomer to the Golgi (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44916", "l": "(2E,4E)-decadienoyl-CoA + H(+) + NADPH = (3E)-decenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35212", "l": "dIDP + H2O => dIMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64728", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S,17S)-dihydroperoxy-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047567", "l": "3-methyleneoxindole reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730872", "l": "Activation of Calcineurin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18355", "l": "ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate => ATP + H2O + K(+)(out) + Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64620", "l": "(E)-sinapoyl alcohol + acetyl-CoA = (E)-sinapoyl actetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52793", "l": "chlorophyllide a + 2 H(+) => Mg(2+) + pheophorbide a"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.21", "l": "\"Enterobacter ribonuclease\""}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0019001", "l": "guanyl nucleotide binding"}, {"i": "REACT:R-HSA-156909", "l": "eEF1A complexes with GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013109", "l": "RHOC GEFs activate RHOC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30439", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + 2 glycyl-tRNA(Gly) = 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)"}, {"i": "EC:2.3.2.17", "l": "\"N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N(6)-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49872", "l": "(+)-dehydrodiconiferyl acid ketone + a quinone + H2O = (+)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031679", "l": "NADH dehydrogenase (plastoquinone) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14901", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = casbene + diphosphate"}, {"i": "EC:4.2.3.8", "l": "\"Casbene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56927", "l": "ATP + L-threonyl-[Goodpasture antigen-binding protein] <=> ADP + H(+) + O-phospho-L-threonyl-[Goodpasture antigen-binding protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24280", "l": "myricetin + 2 S-adenosyl-L-methionine = 2 H(+) + 2 S-adenosyl-L-homocysteine + syringetin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51796", "l": "deoxycohumulone + dimethylallyl diphosphate = colupulone + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31463", "l": "crocetin + UDP-alpha-D-glucose = beta-D-glucosyl crocetin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.86"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42089", "l": "all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047092", "l": "27-hydroxycholesterol 7-alpha-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678927", "l": "UNC93B1 delivers endosomal full-length TLRs to endolysosome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29033", "l": "L-glutamate(out) + Na(+)(out) => L-glutamate(in) + Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1362416", "l": "Frataxin binds iron (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375138", "l": "CDO binds BOC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38412", "l": "1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O => (9Z,12Z,15Z)-octadecatrienoate + 1,3-di-(9Z,12Z,15Z)-octadecatrienoylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13009", "l": "H2O + N-formyl-L-kynurenine = formate + H(+) + L-kynurenine"}, {"i": "EC:3.5.1.9", "l": "\"Arylformamidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74715", "l": "Autophosphorylation of insulin receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852552", "l": "MST1R autophosphorylates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57353", "l": "O2 + reduced [NADPH--hemoprotein reductase] + zeinoxanthin => H(+) + H2O + lutein + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57274", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA => a 2'-deoxyguanosine in DNA + methylglyoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855648", "l": "SALM3 binds LAR-RPTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866277", "l": "AP-2 directly binds some endocytic cargo (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47512", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH = isocholate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31869", "l": "baccharis oxide => (S)-2,3-epoxysqualene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44956", "l": "(2E)-hexenoyl-CoA + H(+) + NADPH = hexanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49036", "l": "(-)-pluviatolide + S-adenosyl-L-methionine = (-)-bursehernin + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.323", "l": "\"(-)-pluviatolide 4-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46314", "l": "3,22-dioxochol-4-en-24-oyl-CoA + CoA => 3-oxochol-4-en-22-oyl-CoA + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57213", "l": "dGTP + methylglyoxal => N(2)-(1-hydroxy-2-oxopropyl)-dGTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654637", "l": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21707", "l": "H2O + L-tyrosine <=> NH4(+) + phenol + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19335", "l": "CO2 + formyl-CoA => H(+) + oxalyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14100", "l": "3-phenylpyruvate + L-aspartate <=> L-phenylalanine + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814555", "l": "Integrator complex processes the 3' end of snRNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047450", "l": "crotonoyl-[acyl-carrier-protein] hydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31622", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose <=> dTDP-3-dehydro-6-deoxy-alpha-D-galactose + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37775", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octanoyl-CoA = 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047645", "l": "alkan-1-ol dehydrogenase (acceptor) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53598", "l": "1-octadecanoyl-sn-glycerol + phosphate => 1-octadecanoyl-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4332236", "l": "CBL neddylates TGFBR2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9010815", "l": "SLITs bind keratan sulfate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009936", "l": "RNASEL cleaves cellular ssRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869438", "l": "Dissociation of clathrin-associated proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34825", "l": "CO2 + 2 CoA + curcumin => (E)-feruloyl-CoA + (E)-feruloylacetyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112395", "l": "Abortive termination of elongation after arrest (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22438", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358791", "l": "Phosphorylation of USP8 by P-AKT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.24", "l": "\"Nucleoside phosphoacylhydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682863", "l": "RNF168 binds DNA DSBs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64203", "l": "an N-(fatty acyl)-L-leucine + H2O <=> a fatty acid + L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350769", "l": "trans-Golgi Network Coat Activation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29544", "l": "alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665727", "l": "FMNL2 binds CDC42:GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975878", "l": "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50563", "l": "acetyl-CoA + N-terminal L-methionyl-L-tryptophyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000103", "l": "CUBN:AMN binds CBLIF:Cbl (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044373", "l": "cytokinin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51394", "l": "CoA + H(+) + N-(9Z-octadecenoyl)-serotonin => (9Z)-octadecenoyl-CoA + serotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38290", "l": "(3S)-citramalate + succinyl-CoA <=> (3S)-citramalyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592297", "l": "Full activation of MMP1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1008220", "l": "Expression of globin genes under control of the beta globin control region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9021068", "l": "PalmS-ESRs bind CAVs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55730", "l": "19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate => 19-(4-hydroxyphenyl)nonadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32668", "l": "coenzyme M + methanethiol => H(+) + hydrogen sulfide + methyl-coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14708", "l": "2 CoA + NADP(+) <=> CoA-disulfide + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9681616", "l": "AP2 binds chlorpromazine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033164", "l": "glycolipid 1,6-alpha-mannosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448673", "l": "Formation of caspase-1 p10/p20 dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912378", "l": "Sialylation of Pre-NOTCH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34682", "l": "ATP + methylphosphonate <=> adenine + alpha-D-ribose 1-methylphosphonate 5-triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408556", "l": "SeO3(2-) combines with GSH to form GSSeSG and GSSG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42671", "l": "L-rhamnofuranose + NADP(+) <=> H(+) + L-rhamnono-1,4-lactone + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19418", "l": "[phosphate](n) + dolichyl diphosphate => [phosphate](n+1) + dolichyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32898", "l": "1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0005507", "l": "copper ion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n4", "l": "\"(-)-trans-carveol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20218", "l": "H(+) + trimethylamine N-oxide => dimethylamine + formaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70510", "l": "LDH tetramer oxidises LACT to PYR (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787525", "l": "TRMT61B methylates adenosine-58 in tRNA yielding 1-methyladenosine-58 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0003988", "l": "acetyl-CoA C-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65966", "l": "ADP + H(+) + phosphate + taurocholate(in) => ATP + H2O + taurocholate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21704", "l": "H2O + L-tyrosine = NH4(+) + phenol + pyruvate"}, {"i": "EC:4.1.99.2", "l": "\"Tyrosine phenol-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30574", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine <=> 6 AMP + 6 diphosphate + enterobactin + 4 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13437", "l": "(E)-cinnamate + UDP-alpha-D-glucose = 1-O-(trans-cinnamoyl)-beta-D-glucose + UDP"}, {"i": "EC:2.4.1.177", "l": "\"Cinnamate beta-D-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174224", "l": "Dissociation of Cdc20 from APC/C complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981355", "l": "RASA1 binds RAS:GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25692", "l": "CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57217", "l": "dGTP + glyoxal => N(2)-(1-hydroxy-2-oxoethyl)-dGTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55517", "l": "11-hydroxycucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] => 11-oxocucurbitadienol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944650", "l": "miR-214 microRNA binds PTEN mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618328", "l": "ATAT acetylates microtubules (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65930", "l": "3-bromo-2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine => 3-bromo-2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692755", "l": "CDK1 phosphorylates MAPK6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21236", "l": "anthranilate + 2 H(+) + NADPH + O2 = 2,3-dihydroxybenzoate + NADP(+) + NH4(+)"}, {"i": "EC:1.14.13.35", "l": "\"Anthranilate 3-monooxygenase (deaminating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25001", "l": "H(+) + N,N-dihydroxy-L-phenylalanine => (E)-phenylacetaldehyde oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029272", "l": "Release of PLCG from FCGR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53544", "l": "chlorophyll a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = 7(1)-hydroxychlorophyll a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29694", "l": "alpha-maltotetraose + phosphate <=> alpha-D-glucose 1-phosphate + alpha-maltotriose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18744", "l": "10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA <=> 10-deacetylbaccatin III + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14427", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61665", "l": "(2E,6E,10E)-geranylgeraniol + ATP => (2E,6E,10E)-geranylgeranyl phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804724", "l": "MDM2 ubiquitinates phosphorylated MDM4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14287", "l": "2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP => sn-glycerol 3-phosphate + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39427", "l": "(2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH = (23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047758", "l": "ATP:2-methylpropanoate phosphotransferase activity"}, {"i": "RHEA:24156", "l": "2-methylpropanoate + ATP = 2-methylpropanoyl phosphate + ADP"}, {"i": "EC:2.7.2.14", "l": "\"Branched-chain-fatty-acid kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647680", "l": "CASP1 cleaves GSDMD (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28304", "l": "diphosphate + germacrene C => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199014", "l": "CD96 binds PVR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34480", "l": "(1R,2R,3R)-prephytoene diphosphate => 15-cis-phytoene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58264", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15576", "l": "N-acetylserotonin + S-adenosyl-L-methionine <=> H(+) + melatonin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10065", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + D-alanine + H2O => (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52717", "l": "a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH => a long-chain primary fatty alcohol + CoA + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53365", "l": "5,6-dihydrouridine(47) in tRNA + NAD(+) => H(+) + NADH + uridine(47) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55587", "l": "adenosine in mRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64298", "l": "(4S,8R,16R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,19-hexaen-18-one + NADP(+) => (4S,8R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,16,19-heptaen-18-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28893", "l": "H(+)(out) + putrescine(out) => H(+)(in) + putrescine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9626848", "l": "S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49921", "l": "(R)-carnitine(out) + O-octanoyl-(R)-carnitine(in) => (R)-carnitine(in) + O-octanoyl-(R)-carnitine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3132759", "l": "TCN1 binds Cbl (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781905", "l": "ZRANB1 binds APC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202510", "l": "Activation of TAK1-TAB2 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687107", "l": "MAPK4,6 translocate to nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781922", "l": "USP13 binds UFD1L:SKP2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.3.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15030", "l": "D-mannitol + NAD(+) => D-mannose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42665", "l": "L-arabinofuranose + NADP(+) => H(+) + L-arabinono-1,4-lactone + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010303", "l": "limit dextrinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50743", "l": "H2O + leukotriene C4 <=> glycine + leukotriene F4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43236", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dihexadecanoyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22865", "l": "L-lysine => D-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12957", "l": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+)"}, {"i": "EC:3.1.1.6", "l": "\"Acetylesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59453", "l": "a long-chain primary fatty alcohol + NADP(+) => a long-chain fatty aldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209840", "l": "Two DITs combine to form thyroxine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44271", "l": "3 H(+) + hexadecanoyl-CoA + 3 malonyl-CoA <=> 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1461971", "l": "Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21475", "l": "ATP + citrate + CoA <=> (3S)-citryl-CoA + ADP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102989", "l": "5-pentadecatrienylresorcinol synthase activity"}, {"i": "MetaCyc:RXN-9618"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40264", "l": "(3R)-hydroxyhexadecanedioyl-CoA + NAD(+) => 3-oxohexadecanedioyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018594", "l": "MECP2 binds LBR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25652", "l": "(2R,5R)-isopulegone + NADP(+) <=> (6R)-isopiperitenone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985943", "l": "p-Y701-STAT1 dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32443", "l": "all-trans-zeaxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.15.21", "l": "\"Zeaxanthin epoxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23844", "l": "ATP + sedoheptulose = ADP + D-sedoheptulose 7-phosphate + H(+)"}, {"i": "EC:2.7.1.14", "l": "\"Sedoheptulokinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004485", "l": "methylcrotonoyl-CoA carboxylase activity"}, {"i": "RHEA:13589", "l": "3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate = ADP + H(+) + phosphate + trans-3-methylglutaconyl-CoA"}, {"i": "EC:6.4.1.4", "l": "\"Methylcrotonoyl-CoA carboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14328", "l": "7,8-dihydroxycoumarin + UDP-alpha-D-glucose <=> daphnin + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.24"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0015181", "l": "arginine transmembrane transporter activity"}, {"i": "RHEA:32143", "l": "L-arginine(in) = L-arginine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32453", "l": "all-trans-phytoene + 2 diphosphate => 2 (2E,6E,10E)-geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015121", "l": "phosphoenolpyruvate:phosphate antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016871", "l": "cycloartenol synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432642", "l": "Phosphorylated TIM transports from the cytosol to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39088", "l": "decanedioyl-CoA + O2 => (2E)-decenedioyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803892", "l": "SFN dimer binds BAX (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29450", "l": "glycolate(in) <=> glycolate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-114684", "l": "Phosphorylation of Syntaxin-4 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55010", "l": "(3S)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+) => (1R,4S)-1-hydroxylimonen-2-one + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0140031", "l": "phosphorylation-dependent protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691154", "l": "HFE binds TFRC dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-203979", "l": "Coat Assembly (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8953013", "l": "E2F7 binds E2F8 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61350", "l": "ADP + estrone 3-sulfate(out) + H(+) + phosphate => ATP + estrone 3-sulfate(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004694", "l": "eukaryotic translation initiation factor 2alpha kinase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0086006", "l": "voltage-gated sodium channel activity involved in cardiac muscle cell action potential"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27889", "l": "2',3'-cyclic AMP + H2O <=> 3'-AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65939", "l": "beta-D-mannose <=> beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018759", "l": "methenyltetrahydromethanopterin cyclohydrolase activity"}, {"i": "RHEA:19053", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin"}, {"i": "EC:3.5.4.27", "l": "\"Methenyltetrahydromethanopterin cyclohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034283", "l": "syn-stemod-13(17)-ene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.23", "l": "\"Acylglycerol lipase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43177", "l": "cytidine(2870) in 25S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(2870) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20905", "l": "(2S)-2-hydroxypropyl-coenzyme M => (S)-1,2-epoxypropane + coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806831", "l": "CYB5Rs reduce MetHb to HbA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012208", "l": "miR-26A and B bind to the 3'UTR of the KPNA2 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645766", "l": "p14ARF mutants do not bind C1QBP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54821", "l": "a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine => a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1011598", "l": "DOCKs bind to RhoGEFs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163551", "l": "triacylglycerol + H2O -> diacylglycerol + fatty acid (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16953", "l": "2-oxoglutarate + N(2)-succinyl-L-ornithine = L-glutamate + N-succinyl-L-glutamate 5-semialdehyde"}, {"i": "EC:2.6.1.81", "l": "\"Succinylornithine transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38990", "l": "nonanoyl-CoA + O2 <=> (2E)-nonenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46601", "l": "[HPr protein]-L-serine + ATP => [HPr protein]-O-phospho-L-serine + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13055", "l": "3-phenylpyruvate + L-alanine => L-phenylalanine + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375131", "l": "Basigin binds CD98 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40133", "l": "(9Z)-hexadecenoate + CoA + H(+) => (9Z)-hexadecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.19", "l": "\"Aspergillopepsin II\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20063", "l": "a ribonucleoside 5'-diphosphate + dCMP + H(+) => 2'-deoxycytidine + a ribonucleoside 5'-triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9681616", "l": "AP2 binds chlorpromazine (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61785", "l": "L-allulose => keto-L-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54791", "l": "[LarE protein]-L-cysteine + ATP + pyridinium-3,5-dicarboxylate mononucleotide <=> [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65517", "l": "5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O => NH4(+) + pre-mycofactocin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43589", "l": "globoside NORint + UDP-alpha-D-galactose => globoside NOR2 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13957", "l": "4 H2O + O2 + 4 sulfur = 6 H(+) + 2 hydrogen sulfide + 2 sulfite"}, {"i": "EC:1.13.11.55", "l": "\"Sulfur oxygenase/reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58828", "l": "(9S,10R)-epoxy-octadecanoate + H2O = 9R,10R-dihydroxyoctadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791069", "l": "Expression of ACADVL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33048", "l": "(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] => (+)-6-endo-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44664", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + a monoacyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44838", "l": "globoside NOR2 (d18:1(4E)) + H(+) + UDP => globoside NORint (d18:1(4E)) + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13834", "l": "L-arginine + pyruvate => 5-guanidino-2-oxopentanoate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56619", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene <=> 1,2,4-trichlorobenzene + chloride + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047544", "l": "2-hydroxybiphenyl 3-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59161", "l": "ATP + docosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] => AMP + diphosphate + docosanoyl-[(phenol)carboxyphthiodiolenone synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15563", "l": "8-O-methylsterigmatocystin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + sterigmatocystin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29309", "l": "FMN + formaldehyde + 2 H(+) + H2O + sulfite => FMNH2 + methanesulfonate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38246", "l": "(9Z)-octadecenoyl-CoA + eicosan-1-ol <=> 1-O-eicosanyl (9Z)-octadecenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008710", "l": "8-amino-7-oxononanoate synthase activity"}, {"i": "MetaCyc:7KAPSYN-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57627", "l": "dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> 3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-976801", "l": "Complement factor I complex formation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36255", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2 = (6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O"}, {"i": "EC:1.14.16.5", "l": "\"Alkylglycerol monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23096", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)"}, {"i": "EC:2.7.1.49", "l": "\"Hydroxymethylpyrimidine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22680", "l": "dCTP + H(+) + H2O = dUTP + NH4(+)"}, {"i": "EC:3.5.4.13", "l": "\"dCTP deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58330", "l": "(Z)-non-6-enal + H(+) + NADPH => (Z)-non-6-en-1-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32343", "l": "(+)-thujan-3-ol + NAD(+) = (+)-thujan-3-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805205", "l": "GPR35 binds kynurenic acid (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38176", "l": "all-trans-retinol + hexadecanoyl-CoA => all-trans-retinyl hexadecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0099529", "l": "neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76373", "l": "N-hydroxylation of 4-aminobiphenyl (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193641", "l": "IKK-beta is recruited (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102882", "l": "beta-acoradiene synthase activity"}, {"i": "MetaCyc:RXN-8423"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-500708", "l": "GRIK3 homomer binds glutamate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55211", "l": "(4R)-hydroxysphinganine 1-phosphate <=> (2R)-hydroxyhexadecanal + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12940", "l": "a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34147", "l": "2-deoxy-L-scyllo-inosose + L-glutamine = 2-deoxy-scyllo-inosamine + 2-oxoglutaramate"}, {"i": "EC:2.6.1.100", "l": "\"L-glutamine:2-deoxy-scyllo-inosose aminotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950637", "l": "Expression of cell division cycle 42 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691131", "l": "CANDI binds CUL1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19246", "l": "N-phenylhydroxylamine => 2-aminophenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1462014", "l": "Alpha-defensins form biologically active dimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55060", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] = a 12-oxojasmonyl-L-alpha-amino acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003882", "l": "CDP-diacylglycerol-serine O-phosphatidyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788999", "l": "HV1-mediated H+ transfer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41048", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol => 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247843", "l": "secretion of WNT ligands (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357429", "l": "AXL autophosphorylates on Y772 and Y814 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655245", "l": "Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669240", "l": "FLNA binds PAK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19986", "l": "NAD(+) + S-(hydroxymethyl)glutathione => H(+) + NADH + S-formylglutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791143", "l": "Expression of YIF1A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008789", "l": "altronate dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5618107", "l": "ATP binding to HSP90 triggers conformation change (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21373", "l": "H(+) + H2O + urethane => CO2 + ethanol + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34585", "l": "CO2 + H2O + pentalenolactone E + succinate => 2-oxoglutarate + O2 + pentalenolactone D"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5576895", "l": "SCNAs:SNCBs transport Na+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193399", "l": "Cholate is translocated from the peroxisomal matrix to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39047", "l": "26-oxohexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + hexacosanedioate + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17824", "l": "hydrogen cyanide + L-cysteine <=> 3-cyano-L-alanine + H(+) + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429714", "l": "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873919", "l": "Phosphorylation of JAK2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10197", "l": "(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate => 2-succinylbenzoate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050293", "l": "steroid-lactonase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051786", "l": "all-trans-retinol 13,14-reductase activity"}, {"i": "RHEA:19193", "l": "A + all-trans-13,14-dihydroretinol = AH2 + all-trans-retinol"}, {"i": "EC:1.3.99.23", "l": "\"All-trans-retinol 13,14-reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032402", "l": "Activated NTRK2 binds FRS3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39878", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol <=> a 1-acyl-sn-glycero-3-phosphocholine + a 2,3-diacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429683", "l": "CERT:ceramide [ER] => ceramide [Golgi] + CERT [ER] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990446", "l": "U1 snRNP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6783880", "l": "PIPOX oxidises PPCA to P6C (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654409", "l": "Activated FGFR3 binds FRS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166869", "l": "TRAF6 binds MEKK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46290", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6783880", "l": "PIPOX oxidises PPCA to P6C (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013147", "l": "RAC1 GDIs block activation of RAC1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28936", "l": "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate => oxaloacetate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12024", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + choline = D-glucose + O-sinapoylcholine"}, {"i": "EC:2.3.1.91", "l": "\"Sinapoylglucose--choline O-sinapoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031764", "l": "type 1 galanin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46742", "l": "cholesta-5,24-dien-3beta-ol + NADP(+) => cholesta-5,7,24-trien-3beta-ol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48201", "l": "H(+) + oxidized [electron-transfer flavoprotein] + undecanoyl-CoA => reduced [electron-transfer flavoprotein] + trans-2-undecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25350", "l": "D-tyrosyl-tRNA(Tyr) + H2O <=> D-tyrosine + tRNA(Tyr)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39101", "l": "acetyl-CoA + octanedioyl-CoA => 3-oxodecanedioyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11636", "l": "NADP(+) + prostaglandin E1 = 15-oxoprostaglandin E1 + H(+) + NADPH"}, {"i": "EC:1.1.1.197", "l": "\"15-hydroxyprostaglandin dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38591", "l": "devancoaminyl-vancomycin + dTDP-beta-L-4-epi-vancosamine = chloroorienticin B + dTDP + H(+)"}, {"i": "EC:2.4.1.311", "l": "\"dTDP-epi-vancosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13078", "l": "an acyl phosphate + D-hexose => a carboxylate + D-hexose phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390909", "l": "HRH2 binds hist (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42209", "l": "an omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+) + NADPH + O2 => an omega-(methylsulfinyl)-alkyl-glucosinolate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51731", "l": "dihydroxyacetone phosphate + H2O <=> dihydroxyacetone + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48614", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase] => [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22790", "l": "(methylsulfanyl)acetate + H(+) + L-methionine => dimethylsulfonioacetate + L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38060", "l": "2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA => 1-octanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36191", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + choline = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33124", "l": "all-trans-heptaprenyl diphosphate => (R)-tetraprenyl-beta-curcumene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12864", "l": "guanosine + H(+) + H2O <=> NH4(+) + xanthosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52805", "l": "(2E,6E)-farnesyl diphosphate => (+)-eremophilene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804527", "l": "INTL1 binds bacterial glycans (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47075", "l": "1-eicosanoylglycerol + H2O <=> eicosanoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42693", "l": "[(1->4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate => [(1->4)-alpha-D-glucosyl](n+2) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43089", "l": "5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine => 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26328", "l": "(8Z,11Z)-5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine <=> (8Z,11Z)-5-(pentadeca- 8,11,14-trien-1-yl)resorcinol-3-methyl ether + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392195", "l": "Gi activation by P2Y purinoceptor 12 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51963", "l": "(Z)-2-methylpropanal oxime <=> 2-methylpropanenitrile + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700149", "l": "Active ALK binds PLCG1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54584", "l": "a guanosine in 18S rRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034781", "l": "N-cyclohexylformamide amidohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448673", "l": "Formation of caspase-1 p10/p20 dimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018550", "l": "tetrachloro-p-hydroquinone reductive dehalogenase activity"}, {"i": "EC:1.8.99.-", "l": "\"With other acceptors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110322", "l": "Formation of Pol zeta complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10268", "l": "2-dehydro-3-deoxy-D-glucarate = 2-hydroxy-3-oxopropanoate + pyruvate"}, {"i": "EC:4.1.2.20", "l": "\"2-dehydro-3-deoxyglucarate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73797", "l": "FAICAR => IMP + H2O (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090583", "l": "protein-phosphocysteine-D-sorbitol-phosphotransferase system transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55089", "l": "24-methylene-24-dihydrolanosterol + S-adenosyl-L-methionine => (24Z)-ethylidenelanosterol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58787", "l": "2-oxoglutarate + a 5'-methyltriphosphate-guanosine-ribonucleotide-snRNA + O2 <=> a 5'-triphospho-guanosine-ribonucleotide-snRNA + CO2 + formaldehyde + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23090", "l": "1-O-alkylglycerone 3-phosphate + ADP + H(+) => ATP + O-alkylglycerone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22144", "l": "cis-aconitate + H2O = D-threo-isocitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63909", "l": "ATP + H2O + pravastatin(in) => ADP + H(+) + phosphate + pravastatin(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0035254", "l": "glutamate receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49566", "l": "2-epi-valiolone + phosphate => D-sedoheptulose 7-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112430", "l": "Formation of P-TEFb complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47543", "l": "7-oxolithocholate + H(+) + NADPH <=> NADP(+) + ursodeoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61104", "l": "(2S)-naringenin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (2S)-dihydrotricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12481", "l": "5-aminolevulinate + pyruvate => 4,5-dioxopentanoate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14056", "l": "D-arabinose 5-phosphate + H2O + phosphoenolpyruvate <=> 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928604", "l": "SFKs phosphorylate VAV2,3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24003", "l": "a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] <=> a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33145", "l": "galactitol(out) => galactitol(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26509", "l": "(9Z)-octadecenamide + H2O <=> (9Z)-octadecenoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165043", "l": "Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55462", "l": "11-hydroxysugiol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 11-hydroxyferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49474", "l": "H(+) + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl-[protein] + UDP => trans-4-hydroxy-L-prolyl-[protein] + UDP-beta-L-arabinofuranose"}]}
{"type": "biolink:MolecularActivity", "ic": "80.661393760018115", "identifiers": [{"i": "GO:0097747", "l": "RNA polymerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103016", "l": "tRNA-specific 2-thiouridylase activity"}, {"i": "MetaCyc:RXN0-2023"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159868", "l": "Furin cleaves pro-factor VII to factor VII (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18455", "l": "[(1->2)-beta-D-glucosyl](n)(out) + ADP + H(+) + phosphate => [(1->2)-beta-D-glucosyl](n)(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799409", "l": "HIPK2 phosphorylates TP53 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42730", "l": "2'-O-methyluridine(2791) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2791) in 21S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51087", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48856", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784189", "l": "JAKs bind LIFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28725", "l": "(S)-allantoin(out) + H(+)(out) => (S)-allantoin(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102680", "l": "campest-4-en-3-one hydroxylase activity"}, {"i": "MetaCyc:RXN-4231"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31024", "l": "squalene => dammara-20,24-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430347", "l": "MigFilin associates with Filamin and F-actin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005046", "l": "KDEL sequence binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60086", "l": "a 4alpha-methyl-3-oxosteroid + CO2 + NADH => a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41283", "l": "H2O + N-tetracosanoyl-sphing-4-enine = sphing-4-enine + tetracosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12131", "l": "2 L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-oxoglutarate + 2 H(+) + L-glutamine + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43646", "l": "3-oxohexadecanoyl-[ACP] + CO2 + CoA => H(+) + malonyl-[ACP] + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052878", "l": "linoleate 8R-lipoxygenase activity"}, {"i": "KEGG.REACTION:R07061"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59996", "l": "3-phenylpropanoate + H(+) + oxidized [electron-transfer flavoprotein] = (E)-cinnamate + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44001", "l": "2-oxoglutarate + 3-methylhexadecanoyl-CoA + O2 => 2-hydroxy-3-methylhexadecanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29704", "l": "L-valine(in) => L-valine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390598", "l": "Myosin Binds ATP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30342", "l": "H(+) + L-tryptophan <=> CO2 + tryptamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43990", "l": "(2E,6E)-omega-hydroxy-farnesyl diphosphate + H2O + NADP(+) => (2E,6E)-farnesyl diphosphate + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4086083", "l": "SUMOylation of ING2 with SUMO1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47690", "l": "Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate + 2 H(+) + NADPH => cis-4-hydroxy-L-proline + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782416", "l": "TRMT1 (hTRM1) dimethylates guanosine-26 of tRNA(Tyr) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014294", "l": "RAC2 binds effectors at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31266", "l": "but-3-ynal + H(+) + pyrroloquinoline quinol <=> but-3-yn-1-ol + pyrroloquinoline quinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17925", "l": "L-arabinofuranose + NAD(+) = H(+) + L-arabinono-1,4-lactone + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033992", "l": "1,5-anhydro-D-fructose dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111879", "l": "PIP2 hydrolysis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48554", "l": "(10Z,15Z)-12-oxophytodienoate + 2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) => 1-(9S,13S-12-oxo-10,15Z-phytodienoyl)-2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009309", "l": "RUNX2 binds STUB1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849900", "l": "SALMs1-3 bind each other in cis interactions (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676591", "l": "2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14055", "l": "3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate => D-arabinose 5-phosphate + H2O + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25528", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate"}, {"i": "EC:3.1.3.86", "l": "\"Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20954", "l": "beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004117", "l": "calmodulin-dependent cyclic-nucleotide phosphodiesterase activity"}, {"i": "REACT:R-HSA-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40369", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34544", "l": "N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31506", "l": "beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphoenolpyruvate <=> 4,6-Me(COOH)C-beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879562", "l": "SLCO2B1 has a narrow substrate specificity (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40384", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49792", "l": "eicosanoyl-CoA + glycine = CoA + H(+) + N-eicosanoylglycinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357483", "l": "RAC1 binds PAK1-3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30668", "l": "germacra-1(10),4,11(13)-trien-12-ol + H2O + 2 NADP(+) => germacra-1(10),4,11(13)-trien-12-oate + 3 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052586", "l": "oxidoreductase activity, acting on other nitrogenous compounds as donors, with a quinone or similar compound as acceptor"}, {"i": "EC:1.7.5.-", "l": "\"With a quinone or similar compound as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625548", "l": "Hypochlorous acid (HOCL) oxidizes Cys residues to form Cys-sulfenyl chloride (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47041", "l": "5-taurinomethyluridine(34) in tRNA + AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] => 5-taurinomethyl-2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40038", "l": "ATP + L-glutamate + N-acetyl-L-aspartate <=> ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578717", "l": "BCDIN3D dimethylates 5' phosphate of pre-miR-145 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849094", "l": "ARHGAP35 binds RASA1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51644", "l": "cholesterol + H(+) + NADH + O2 = cholesta-5,7-dien-3beta-ol + 2 H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917841", "l": "Acidification of Tf:TfR1 containing endosome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53418", "l": "8-demethyl-8-(methylamino)riboflavin + H(+) + S-adenosyl-L-homocysteine => 8-amino-8-demethylriboflavin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43637", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) => 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13192", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O <=> 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033422", "l": "CCC codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0140674", "l": "ATP-dependent histone loader activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102518", "l": "(11Z)-eicosenoate 14-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112437", "l": "Formation of NELF complex  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33027", "l": "4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spheroidene = 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + spheroiden-2-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61107", "l": "(2S)-naringenin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (2S)-dihydrotricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070281", "l": "pyridoxamine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204549", "l": "Caveolin-1 binds Basigin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.23"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15932", "l": "2 H(+) + 2 H2O + methylenediurea <=> CO2 + N-(hydroxymethyl)urea + 2 NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11718", "l": "a dicarboxylate + NH4(+) => a monoamide of a dicarboxylate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64142", "l": "a fatty acid + L-asparagine => an N-(fatty acyl)-L-asparagine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74726", "l": "Dissociation of insulin from insulin receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357831", "l": "CYLD is phosphorylated by IKK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43037", "l": "L-cysteine => 2-aminoprop-2-enoate + H(+) + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033520", "l": "TYSND1 cleaves TYSND1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38418", "l": "1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + 2,3-di-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23343", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate <=> D-arabinose + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004931", "l": "extracellularly ATP-gated cation channel activity"}, {"i": "REACT:R-HSA-877187", "l": "P2X7 mediates loss of intracellular K+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9644926", "l": "Transcription of DDIT3 (CHOP, GADD153) in response to amino acid deficiency (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034016", "l": "NTF3 binds NTRK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58584", "l": "dihydroprecondylocarpine acetate = (-)-tabersonine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-688137", "l": "RIP2 is K63 polyubiquitinated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162657", "l": "Inactivation of Myt1 kinase (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11368", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H(+) + NADH + O2 = 1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-622415", "l": "RIP2 binds NEMO (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19039", "l": "an ethanediol => an epoxide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165680", "l": "Formation of active mTORC1 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.59", "l": "\"Long-chain fatty acid adenylase/transferase FadD26\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29867", "l": "AMP + ITP = ADP + IDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.146", "l": "\"(Iso)eugenol O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031859", "l": "platelet activating factor receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15450", "l": "homogentisate + O2 => 4-maleylacetoacetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58345", "l": "beta-D-glucosyl-(1->3)-O-lithocholate + H2O => D-glucose + lithocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798749", "l": "Exocytosis of specific granule lumen proteins (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41922", "l": "(3R)-hydroxyoctadecanoyl-[ACP] + NADP(+) => 3-oxooctadecanoyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047322", "l": "[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37708", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA => 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-182986", "l": "CBL-mediated ubiquitination of CIN85 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102362", "l": "esculetin 3-O-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-13472"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20927", "l": "a [peptide]-C-terminal (2S)-2-hydroxyglycine <=> a [peptide]-C-terminal amide + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10815", "l": "H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) <=> 2 H(+) + N-succinyl-L-glutamate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400434", "l": "FFAR1 binds fatty acids (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198813", "l": "GSTO dimers reduce DeHA to AscH- (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36225", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + H(+) + phosphoethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102395", "l": "9-cis-beta-carotene 9',10'-cleavage oxygenase activity"}, {"i": "MetaCyc:RXN-13642"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985929", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647746", "l": "EML4 trimerizes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37352", "l": "cytidine 2'-phosphate + H2O => cytidine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004034", "l": "aldose 1-epimerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62619", "l": "a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose <=> a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20428", "l": "2-oxoglutarate + ATP + hydrogencarbonate <=> (S)-oxalosuccinate + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043718", "l": "2-hydroxymethylglutarate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62544", "l": "2 [Fe(II)cytochrome c] + 3 H(+) + ouabagenin = 2 [Fe(III)cytochrome c] + dihydroouabagenin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047065", "l": "sulochrin oxidase [(-)-bisdechlorogeodin-forming] activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43446", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1,2-ditetradecanoyl-sn-glycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173769", "l": "RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432164", "l": "Ca2+ influx into the post-synaptic cell (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0005346", "l": "purine ribonucleotide transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52667", "l": "a short-chain (3S)-3-hydroxyacyl-CoA <=> a short-chain (2E)-enoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29069", "l": "CO2 + menaquinol-8 => formate + H(+) + menaquinone-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44432", "l": "2 a 1-acylglycerol = a 1,2-diacylglycerol + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11641", "l": "a (2R,3R)-flavan-3-ol + 2 NAD(+) => an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42858", "l": "1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate => 1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654571", "l": "Activated FGFR1 binds FRS3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909780", "l": "(R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046820", "l": "4-amino-4-deoxychorismate synthase activity"}, {"i": "KEGG.REACTION:R01716"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654404", "l": "Activated FGFR2 binds SHC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48173", "l": "ganglioside GM2 + H2O => N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008479", "l": "FBXW7 polyubiquitinates RUNX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63502", "l": "NADP(+) + sulfinamide glutathione => H(+) + NADPH + S-nitrosoglutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5658438", "l": "SPRED dimer binds NF1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23106", "l": "D-ribulose 5-phosphate => D-arabinose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45270", "l": "4',4'-dihydroxyechinenone + A + H2O => 4'-hydroxyechinenone + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015280", "l": "ligand-gated sodium channel activity"}, {"i": "REACT:R-HSA-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168886", "l": "Hemopexin binds Hemes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19308", "l": "3-hydroxybenzoyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12648", "l": "CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + S-2-(indol-3-yl)acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372564", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33949", "l": "2'-N-acetylparomamine + H(+) + UDP => 2-deoxystreptamine + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204850", "l": "Interaction of Tie2 and Dok-2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6794346", "l": "NRXNs bind NLGNs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426032", "l": "DAG is metabolized by DAGL to 2-AG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864577", "l": "TFAP2C translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48498", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31626", "l": "L-olivosyl-oleandolide + S-adenosyl-L-methionine <=> H(+) + L-oleandrosyl-oleandolide + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034800", "l": "trinitrophenol dihydride denitratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700149", "l": "Active ALK binds PLCG1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70982", "l": "Fumarate + H2O <=> (S)-Malate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019134", "l": "glucosamine-1-phosphate N-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690701", "l": "SHP1 binds p-CD22 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18421", "l": "acetyl-CoA + chloramphenicol = chloramphenicol 3-acetate + CoA"}, {"i": "EC:2.3.1.28", "l": "\"Chloramphenicol O-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66483", "l": "gypsogenin + UDP-alpha-D-glucose <=> gypsogenin 28-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51551", "l": "(R)-tetrahydropapaverine + S-adenosyl-L-methionine <=> (R)-N-methyltetrahydropapaverine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5336182", "l": "GPR37 binds prosaptide (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.n1", "l": "\"Peptidoglycan lytic exotransglycosylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031735", "l": "CCR10 chemokine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27410", "l": "3 a menaquinone + protoporphyrinogen IX => 3 a menaquinol + protoporphyrin IX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354066", "l": "Translocation of PTK2 to Focal complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1369028", "l": "ABCAs mediate lipid efflux (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63478", "l": "15-oxoprostaglandin E2 + H(+) + NADPH => NADP(+) + prostaglandin E2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54815", "l": "(+)-7-isojasmonate + ATP + L-isoleucine <=> AMP + diphosphate + H(+) + L-isoleucine-(+)-7-isojasmonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507875", "l": "Aquaporins passively transport urea into cells (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912355", "l": "Glycosylation of Pre-NOTCH by FRINGE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55445", "l": "O2 + oleanolate + reduced [NADPH--hemoprotein reductase] => cochalate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41729", "l": "(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665525", "l": "sCD163 translocates from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37803", "l": "a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.133", "l": "\"Glucan 1,4-alpha-maltohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034564", "l": "4,4'-dihydroxy-alpha-methylstilbene dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24613", "l": "17beta-estradiol + NAD(+) => estrone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22894", "l": "5,10-methenyltetrahydrofolate + NADH => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68603", "l": "ORC5 binds ORC2:ORC3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18344", "l": "D-xylono-1,4-lactone + H2O <=> D-xylonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30646", "l": "phosphate + S-methyl-5'-thioinosine <=> hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35365", "l": "isopentadecanoyl-CoA + NADP(+) => (2E)-13-methyltetradecenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51558", "l": "(S)-N-methylglaucine + H(+) + S-adenosyl-L-homocysteine => (S)-glaucine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18680", "l": "[Fe(III)-cytochrome b5] + L-ascorbate <=> [Fe(II)-cytochrome b5] + H(+) + monodehydro-L-ascorbate radical"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20487", "l": "(S)-cheilanthifoline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20515", "l": "2-arylpropionate + CO2 => 2-aryl-2-methylmalonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24065", "l": "2 5-aminolevulinate => H(+) + 2 H2O + porphobilinogen"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15265", "l": "1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate"}, {"i": "EC:2.6.99.2", "l": "\"Pyridoxine 5'-phosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102532", "l": "genkwanin 6-hydroxylase activity"}, {"i": "MetaCyc:RXN-14748"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34555", "l": "a (2S)-2-hydroxycarboxylate + NAD(+) = a 2-oxocarboxylate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "78.819800280251172", "identifiers": [{"i": "GO:0005048", "l": "signal sequence binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021609", "l": "ESR-associated SRC autophosphorylates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "75.076548671259488", "identifiers": [{"i": "GO:0004520", "l": "endodeoxyribonuclease activity"}, {"i": "REACT:R-HSA-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49829", "l": "(5E)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,5E)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5260201", "l": "p-AKT2 phosphorylates C2CD5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928614", "l": "EFNB:GRB4 binds GIT1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165195", "l": "GTP loading by Rheb (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.25"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30558", "l": "GTP + L-glutamate + oxidized coenzyme F420-0 <=> GDP + H(+) + oxidized coenzyme F420-1 + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17284", "l": "(2S)-4-acetamido-2-aminobutanoate <=> H2O + L-ectoine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020274", "l": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44537", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24866", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + 2-oxoglutarate + O2 => 4-O-deacetyl-16-O-demethylvindoline + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42163", "l": "(11Z,14Z)-eicosadienoyl-CoA + AH2 + O2 <=> (5Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102284", "l": "L-threo-sphinganine reductase activity"}, {"i": "MetaCyc:RXN-12645"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086058", "l": "voltage-gated calcium channel activity involved in Purkinje myocyte cell action potential"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.70", "l": "\"Glucan 1,6-alpha-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418662", "l": "Src activation following P2Y purinoceptor activation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168412", "l": "MDP elicits a NOD2 response (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2090079", "l": "GLB1 hydrolyses linker chain(2) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47073", "l": "1-eicosanoylglycerol + H2O => eicosanoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010314", "l": "phosphatidylinositol-5-phosphate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68954", "l": "Mcm2-7 is phosphorylated by DDK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617852", "l": "FOXO3,FOXO4,(FOXO1) bind GADD45A gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53162", "l": "an N-acylethanolamine + H(+) + sn-glycerol 3-phosphate => H2O + N-acyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32079", "l": "(13E)-labda-7,13-dien-15-yl diphosphate + H2O = (13E)-labda-7,13-dien-15-ol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433418", "l": "Phosphorylation of JAK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0016002", "l": "sulfite reductase activity"}, {"i": "MetaCyc:SULFITE-REDUCTASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31912", "l": "beta-D-fructose 1,6-bisphosphate + methylglyoxal => 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53880", "l": "ADP-alpha-D-glucose + D-glucose 6-phosphate = ADP + alpha,alpha-trehalose 6-phosphate + H(+)"}, {"i": "EC:2.4.1.347", "l": "\"Alpha,alpha-trehalose-phosphate synthase (ADP-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849900", "l": "SALMs1-3 bind each other in cis interactions (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669013", "l": "EDA-3 binds EDA2R (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44785", "l": "2-demethylmenaquinol-10 + S-adenosyl-L-methionine => H(+) + menaquinol-10 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213192", "l": "Hemidesmosome formation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63053", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + methanol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140432", "l": "5'-hydroxyl dinucleotide hydrolase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19557", "l": "AH2 + O2 + pregna-4,9(11)-diene-3,20-dione = 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O"}, {"i": "EC:1.14.99.24", "l": "\"Steroid 9-alpha-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141409", "l": "Mad1 binds kinetochore (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3204303", "l": "MRE11 binds cytosolic DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64632", "l": "acetyl-CoA + butan-1-ol = butyl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50293", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37401", "l": "1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49285", "l": "8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP => CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53773", "l": "chenodeoxycholate + lithocholoyl-CoA => chenodeoxycholoyl-CoA + lithocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42794", "l": "cholesteryl hexadecanoate + CoA => cholesterol + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018794", "l": "RHOV binds effectors at the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49831", "l": "(5E)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,5E)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52382", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1299297", "l": "Activation of THIK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0000049", "l": "tRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28152", "l": "CoA + H(+) + N(1)-acetylspermidine => acetyl-CoA + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38803", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "80.661393760018115", "identifiers": [{"i": "GO:0005245", "l": "voltage-gated calcium channel activity"}, {"i": "REACT:R-HSA-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41088", "l": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol => 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38302", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA <=> 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433454", "l": "Phosphorylation of GAB2 by SFKs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-984733", "l": "Kinesin-3 is a dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805740", "l": "SETD8 methylates TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39469", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+) => (2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54023", "l": "L-lysyl-[protein] + propanoyl-CoA <=> CoA + H(+) + N(6)-propanoyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29681", "l": "formate(out) => formate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14444", "l": "acetyl-CoA + gentamicin C <=> CoA + H(+) + N(3)-acetylgentamycin C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5612510", "l": "Expression of PTCH1 is repressed by GLI3R in the absence of Hh signaling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46639", "l": "5beta-dihydrotestosterone + NADP(+) <=> H(+) + NADPH + testosterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48955", "l": "14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) <=> 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20514", "l": "2-aryl-2-methylmalonate + H(+) => 2-arylpropionate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247839", "l": "Retromer associates with WLS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15735", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2 => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010855", "l": "adenylate cyclase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11933", "l": "2-hydroxy-2-methylpropanenitrile => acetone + hydrogen cyanide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36510", "l": "docosanoyl-CoA + H(+) + malonyl-CoA <=> 3-oxotetracosanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865425", "l": "RUNX2 binds CBFB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9640167", "l": "RRAGA,B exchanges GDP for GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2464822", "l": "RDH12 reduces atRAL to atROL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.52"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13515", "l": "H(+) + NADH + orotate => (S)-dihydroorotate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047711", "l": "blasticidin-S deaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45480", "l": "gamma-hexachlorocyclohexane = (3R,4S,5S,6R)-pentachlorocyclohexene + chloride + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043803", "l": "hydroxyneurosporene-O-methyltransferase activity"}, {"i": "RHEA:30903", "l": "demethylspheroidene + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + spheroidene"}, {"i": "EC:2.1.1.210", "l": "\"Demethylspheroidene O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450770", "l": "MWH binds to RHO1:GTP and is activated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710254", "l": "GSDME oligomerizes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804879", "l": "MDM2 ubiquitinates TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61125", "l": "kaempferol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + quercetin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668023", "l": "TPST1,2 transfer SO4(2-) from PAPS to FVIII (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58037", "l": "8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) => 8-epi-inunolide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375135", "l": "Basigin binds Matrix metalloproteinase-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050160", "l": "orsellinate-depside hydrolase activity"}, {"i": "MetaCyc:ORSELLINATE-DEPSIDE-HYDROLASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59575", "l": "H2O + L-homocarnosine <=> 4-aminobutanoate + L-histidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027425", "l": "LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047913", "l": "gallate 1-beta-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694579", "l": "Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174931", "l": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63917", "l": "5-fluorouridine + ATP => 5-fluorouridine 5'-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21859", "l": "cyclohexa-1,5-diene-1-carbonyl-CoA + H2O <=> 6-hydroxycyclohex-1-ene-1-carbonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.16", "l": "\"Xaa-Trp aminopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45038", "l": "3 [Fe(II)cytochrome c] + 3 H(+) + nitric oxide => 3 [Fe(III)cytochrome c] + hydroxylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.-.-", "l": "\"Acting on the CH-CH group of donors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51079", "l": "2-hydroxy-17beta-estradiol + 3'-phosphoadenylyl sulfate <=> 2-hydroxy-17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33059", "l": "(R)-dihydrolipoamide + NAD(+) = (R)-lipoamide + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5336184", "l": "GPR37L binds prosaposin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56341", "l": "ent-isokauren-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-isokaurene-2beta,3beta-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12927", "l": "H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] => D-erythrose 4-phosphate + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63666", "l": "H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+) => (S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102533", "l": "genkwanin 4'-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-14750"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418172", "l": "F2R binds ARRB2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645598", "l": "RRAGC,D hydrolyzes GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50791", "l": "NADP(+) + pentan-2-one <=> (E)-pent-3-en-2-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52261", "l": "a 7(1),7(1)-dihydroxybacteriochlorophyllide c => a bacteriochlorophyllide e + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9652165", "l": "MAP2K mutants constitutively phosphorylate MAPKs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54466", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexanoate => 1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789615", "l": "Expression of STAT3-upregulated extracellular proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648017", "l": "EML4 binds to microtubules (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58605", "l": "FAD + 2 H(+) + NADH + O2 => FADH2-C4alpha-hydroperoxide + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046981", "l": "beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13755", "l": "2-oxoglutarate + H(+) + L-glutamine + NADH => 2 L-glutamate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "65.690062451777465", "identifiers": [{"i": "GO:0016818", "l": "hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"}, {"i": "EC:3.6.1.-", "l": "\"In phosphorus-containing anhydrides\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57032", "l": "(E)-2-((N-methylformamido) methylene)succinate + H(+) + 2 H2O = CO2 + formate + methylamine + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63965", "l": "sphinga-4E,14Z-dienine-1-phosphate => (2E,12Z)-hexadecadienal + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58016", "l": "8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714483", "l": "RAC2 translocates to the ER membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18417", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = CMP + ganglioside GM3 (d18:1(4E)) + H(+)"}, {"i": "EC:2.4.99.9", "l": "\"Lactosylceramide alpha-2,3-sialyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34962", "l": "(R)-carnitine(in) <=> (R)-carnitine(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047414", "l": "2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874685", "l": "CBL binds MET (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2179413", "l": "Activated PKC-alpha  activate MMP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68914", "l": "DNA polymerase alpha:primase binds at the origin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015527", "l": "glycerol-phosphate:inorganic phosphate antiporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008613", "l": "diuretic hormone activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45801", "l": "15-demethylaclacinomycin T + AH2 + O2 => 10-decarboxymethylaclacinomycin T + A + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015408", "l": "ABC-type ferric iron transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57634", "l": "H(+) + H2O + ML-236A carboxylate + oxidized [NADPH--hemoprotein reductase] => ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66685", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[GAPDH] => L-cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811427", "l": "COPI vesicle uncoating at the ER (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102681", "l": "isoamylase (maltodextrin-releasing) activity"}, {"i": "MetaCyc:RXN-4301"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57982", "l": "(20S)-ginsenoside F1 + H(+) + UDP => (20S)-protopanaxatriol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592362", "l": "Activation of proMMP7 by MMP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35036", "l": "4-aminobutanoate(in) => 4-aminobutanoate(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050415", "l": "formimidoylglutamase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55608", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34372", "l": "H2O + indole-3-acetamide => (indol-3-yl)acetate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44344", "l": "ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate = ADP + dapdiamide A + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10180", "l": "(6S)-10-formyltetrahydrofolate + H2O + NADP(+) = (6S)-5,6,7,8-tetrahydrofolate + CO2 + H(+) + NADPH"}, {"i": "EC:1.5.1.6", "l": "\"Formyltetrahydrofolate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2203480", "l": "COLEC11 binds ligands (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66062", "l": "H2O + kynurenate + L-2-aminohexanoate => 2-oxohexanoate + L-kynurenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26433", "l": "(+)-copalyl diphosphate + H2O <=> diphosphate + phyllocladan-16alpha-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30442", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + 2 glycyl-tRNA(Gly) <=> 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.42", "l": "\"FMN reductase (NADH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53624", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + tsukubadiene"}, {"i": "EC:4.2.3.159", "l": "\"Tsukubadiene synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102203", "l": "brassicasterol glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2203516", "l": "Alpha-1-Microglobulin is cleaved (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17505", "l": "H2O + N-(long-chain fatty acyl)ethanolamine = a long-chain fatty acid + ethanolamine"}, {"i": "EC:3.5.1.60", "l": "\"N-(long-chain-acyl)ethanolamine deacylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25241", "l": "(S)-2-ureidoglycine + H2O = (S)-ureidoglycolate + NH4(+)"}, {"i": "EC:3.5.3.26", "l": "\"(S)-ureidoglycine aminohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45201", "l": "(6S)-5,6,7,8-tetrahydrofolate + [methyl-Co(III) corrinoid Fe-S protein] => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + [Co(I) corrinoid Fe-S protein] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65899", "l": "glyoxylate + L-kynurenine <=> glycine + H2O + kynurenate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044102", "l": "purine deoxyribosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42091", "l": "all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.249"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11854", "l": "adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate => phosphate + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.87"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16245", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA"}, {"i": "EC:2.3.1.121", "l": "\"1-alkenylglycerophosphoethanolamine O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66668", "l": "5-methylorsellinate + O2 + reduced [NADPH--hemoprotein reductase] = 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45794", "l": "[ribosomal protein S23]-trans-3-hydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + [ribosomal protein S23]-L-proline + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051508", "l": "stigmasterol UDP-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624798", "l": "LBR binds KPNB1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043877", "l": "galactosamine-6-phosphate isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8939335", "l": "RNF181 polyubiquinates BCL10 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036199", "l": "cholest-4-en-3-one 26-monooxygenase activity"}, {"i": "KEGG.REACTION:R09859"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30660", "l": "4-(phosphooxy)-L-threonine + H2O => 4-hydroxy-L-threonine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17664", "l": "ATP + CoA + succinate <=> ADP + phosphate + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "76.125169645393314", "identifiers": [{"i": "GO:0016209", "l": "antioxidant activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23144", "l": "H2O + N-acetyl-alpha-D-glucosamine + NAD(+) = 2 H(+) + N-acetyl-D-glucosaminate + NADH"}, {"i": "EC:1.1.1.240", "l": "\"N-acetylhexosamine 1-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419011", "l": "Transhomodimerization of Nectins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21745", "l": "S-adenosyl-L-methionine => 1-aminocyclopropane-1-carboxylate + H(+) + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10023", "l": "H2O + L-saccharopine + NADP(+) <=> (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45895", "l": "an N-acylsphing-4-enine + CDP-ethanolamine <=> an N-acylsphing-4-enine 1-phosphoethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62642", "l": "[mycoredoxin]-L-disulfide + an alcohol + H2O => [mycoredoxin]-L-dithiol + a hydroperoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390912", "l": "HRH1 binds hist (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11327", "l": "all-trans-octaprenyl diphosphate + isopentenyl diphosphate <=> all-trans-nonaprenyl diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48779", "l": "O2 + prostaglandin H2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxyprostaglandin H2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53167", "l": "H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204798", "l": "Interaction of Tie2 and p85 of PI3K (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16114", "l": "2 cob(II)alamin--[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+) => 2 apo--[cyanocobalamin reductase] + 2 cyanocob(III)alamin + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51581", "l": "a fatty acid(out) + ATP(in) + CoA(in) + H(+)(out) => a fatty acyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37289", "l": "ADP + H(+) + L-alanyl-L-leucine(in) + phosphate => ATP + H2O + L-alanyl-L-leucine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192010", "l": "5beta-cholestan-3alpha, 7alpha, 12alpha-triol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198621", "l": "AKT phosphorylates caspase-9 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0140327", "l": "flippase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22477", "l": "4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+) => 4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68826", "l": "Free CDT1 associates with CDC6:ORC:origin complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36782", "l": "2-oxoglutarate + GDP-alpha-D-perosamine <=> GDP-4-dehydro-alpha-D-rhamnose + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102202", "l": "soladodine glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32477", "l": "glycine betaine + 3 H(+) + 3 S-adenosyl-L-homocysteine => glycine + 3 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322422", "l": "Beta-catenin recruits SMARCA4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14467", "l": "L-histidinol + phosphate => H2O + L-histidinol phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662786", "l": "FURIN cleaves ADAM17 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983158", "l": "Trimming of peptides in ER (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54084", "l": "7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine = archaeosine(15) in tRNA + L-glutamate"}, {"i": "EC:2.6.1.97", "l": "\"Archaeosine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30584", "l": "2-demethylmenaquinol-8 + H(+) + trimethylamine N-oxide => 2-demethylmenaquinone-8 + H2O + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27291", "l": "A + formate + H(+) => AH2 + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382061", "l": "Extracellular processing of novel PDGFs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19056", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O <=> H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102372", "l": "alpha-amyrin 28-monooxygenase activity"}, {"i": "MetaCyc:RXN-13500"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354073", "l": "Autophosphorylation of PTK2 at Y397 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32671", "l": "ATP + UDP-N-acetyl-alpha-D-glucosamine = ADP + H(+) + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate"}, {"i": "EC:2.7.1.176", "l": "\"UDP-N-acetylglucosamine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34154", "l": "3-amino-2,3-dideoxy-scyllo-inosose + L-glutamine <=> 2-deoxystreptamine + 2-oxoglutaramate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54149", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene => 1-hydroxy-all-trans-1,2-dihydro-neurosporene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2012082", "l": "Autocatalytic phosphorylation of FGFR3 cysteine mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42967", "l": "uridine(54/55) in tRNA <=> pseudouridine(54/55) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42103", "l": "ATP + carbamoyl phosphate + H2O + kanamycin A <=> 6''-O-carbamoylkanamycin A + AMP + diphosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63169", "l": "fumarate + L-cysteine => S-(2-succino)-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34391", "l": "beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 UDP-alpha-D-galactofuranose = [beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 H(+) + 28 UDP"}, {"i": "EC:2.4.1.288", "l": "\"Galactofuranosylgalactofuranosylrhamnosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,5/1,6-galactofuranosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34905", "l": "glutathione disulfide + 3 H2O + selenodiglutathione => 4 glutathione + 2 H(+) + selenite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57844", "l": "fraxetin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sideretin (reduced form)"}, {"i": "EC:1.14.14.164", "l": "\"Fraxetin 5-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981809", "l": "ST6GALNAC3/4 can add a sialic acid to the sialyl T antigen to form the disialyl T antigen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.2.9"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0019202", "l": "amino acid kinase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0042556", "l": "eukaryotic elongation factor-2 kinase regulator activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901612", "l": "cardiolipin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696183", "l": "AOC3 deaminates BZAM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047246", "l": "luteolin-7-O-glucuronide 7-O-glucuronosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22343", "l": "3-hydroxybenzyl alcohol + NADP(+) <=> 3-hydroxybenzaldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008697", "l": "4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8935732", "l": "RUNX1 binds SIN3A,(SIN3B) co-repressor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30947", "l": "(2E,6E)-farnesyl diphosphate + H2O = 10-epi-gamma-eudesmol + diphosphate"}, {"i": "EC:4.2.3.84", "l": "\"10-epi-gamma-eudesmol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38828", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682863", "l": "RNF168 binds DNA DSBs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391905", "l": "Oxoeicosanoid receptor can bind oxoeicosanoid (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22106", "l": "3''-deamino-3''-oxonicotianamine + L-glutamate => 2-oxoglutarate + nicotianamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n15"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39211", "l": "(3R)-hydroxyhexacosanoyl-CoA = (2E)-hexacosenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692809", "l": "CDC42 binds effectors at the ER membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20534", "l": "H2O + pyridoxal 5'-phosphate => phosphate + pyridoxal"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070694", "l": "deoxyribonucleoside 5'-monophosphate N-glycosidase activity"}, {"i": "REACT:R-HSA-8953339", "l": "DNPH1 hydrolyses dGMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010357", "l": "homogentisate solanesyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46071", "l": "(3E)-nonenoyl-CoA <=> (2E)-nonenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350158", "l": "LGMN degrades GC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62068", "l": "2-deoxy-D-glucose 6-phosphate + NADP(+) = 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4686998", "l": "Defective MPDU1 does not promote transfer of Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 by ALG12 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57193", "l": "H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] => glycolate + H(+) + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43798", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32102", "l": "S-adenosyl-L-methionine + TRIBOA beta-D-glucoside <=> DIMBOA beta-D-glucoside + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55077", "l": "4-methylsulfanyl-2-oxobutanoate + H(+) => 3-methylsulfanylpropanal + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18053", "l": "H2O + paraoxon = 4-nitrophenol + diethylphosphate + 2 H(+)"}, {"i": "EC:3.1.8.1", "l": "\"Aryldialkylphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48414", "l": "globoside Gb4Cer + N-acetyl-alpha-D-galactosamine => globoside IV3GalNAc-Gb4Cer + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62131", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dGTP <=> a 2'-deoxyribonucleoside 5'-diphosphate + dGDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48457", "l": "1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O => 2-octanoyl-3-O-beta-D-galactosyl-sn-glycerol + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57835", "l": "5-oxopentanoate + H2O + NADP(+) <=> glutarate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033793", "l": "aureusidin synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.26"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814831", "l": "TBC1D20 binds RAB1:GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18141", "l": "NAD(+) + trans-cyclohexane-1,2-diol = 2-hydroxycyclohexan-1-one + H(+) + NADH"}, {"i": "EC:1.1.1.174", "l": "\"Cyclohexane-1,2-diol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66549", "l": "3'-phosphoadenylyl sulfate + 4-nitrophenol => 4-nitrophenyl sulfate + adenosine 3',5'-bisphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951977", "l": "Acetylated RUNX3 binds to BRD2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11602", "l": "ADP + CDP => ATP + CMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592316", "l": "Initial activation of proMMP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388809", "l": "CTLA-4 binds B7-1/B7-2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682011", "l": "LC3 binds ATG7 dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48363", "l": "a 1,2-saturated fatty acid + H2O2 <=> a 2-hydroxy fatty acid + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58375", "l": "(E)-oct-2-en-1-ol + NADP(+) <=> (2E)-octenal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202713", "l": "CD84 homodimerises (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110210", "l": "TDG glycosylase mediated recognition and binding of an ethenocytosine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73800", "l": "SAICAR => AICAR + Fumarate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626549", "l": "IQGAPs bind CALM1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19824", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34428", "l": "(-)-lariciresinol + NADP(+) => (-)-pinoresinol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44348", "l": "ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate = ADP + dapdiamide B + H(+) + phosphate"}, {"i": "EC:6.3.2.47", "l": "\"Dapdiamide synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157933", "l": "NICD2 traffics to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16873", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)"}, {"i": "RHEA:62372", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)"}, {"i": "EC:2.1.1.74", "l": "\"Methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))-methyltransferase (NAD(P)H-oxidizing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55584", "l": "adenosine in mRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.348", "l": "\"mRNA m(6)A methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37970", "l": "galactitol + NADP(+) <=> D-galactose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60889", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine-phospho-ribonucleoside in mRNA + H2O => (N(7)-methyl 5'-triphospho-guanosine)-guanosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102391", "l": "decanoate-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52173", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0031634", "l": "replication fork barrier binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015355", "l": "secondary active monocarboxylate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428917", "l": "G13 activation by TP receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109862", "l": "MAP2K2 phosphorylates MAPK1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102610", "l": "(+)-secoisolariciresinol glucosyltransferase activity"}, {"i": "MetaCyc:RXN-15442"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46634", "l": "7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP(+) => 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66198", "l": "CoA + H(+) + N-acetyltryptamine => acetyl-CoA + tryptamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9619355", "l": "CaMKK autophosphorylates in the cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39374", "l": "3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851979", "l": "BTNL9 binds immune cell surfaces (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176416", "l": "NEDD4L ubiquitin ligase binds SMAD7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102342", "l": "3-oxo-cerotoyl-CoA reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26497", "l": "chloride + FADH2 + L-tryptophan + O2 <=> 7-chloro-L-tryptophan + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39439", "l": "(3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA = (2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849900", "l": "SALMs1-3 bind each other in cis interactions (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36398", "l": "cholesta-5,7-dien-3beta-ol + NADP(+) <=> cholesta-5,7,24-trien-3beta-ol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28445", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + dodecanoyl-[ACP] <=> dodecanoyl-(Kdo)2-lipid IVA + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694583", "l": "ABHD4 hydrolyses NAPE (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191654", "l": "c-src associates with Cx43 in gap junctions (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35656", "l": "2 ATP => 3',3'-c-di-AMP + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204871", "l": "Interaction of Tie2 and Grb2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873918", "l": "Transphosphorylation of JAK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44740", "l": "27-O-demethylrifamycin SV + S-adenosyl-L-methionine = H(+) + rifamycin SV + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.315", "l": "\"27-O-demethylrifamycin SV methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26013", "l": "2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) <=> 3,7-dideoxy-D-threo-hepto-2,6-diuolosonate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66567", "l": "histamine + L-glutaminyl-[protein] <=> 5-histaminyl-L-glutamyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29045", "l": "(6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65364", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O = a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40225", "l": "4,8-dimethylnonanoate + CoA + H(+) => 4,8-dimethylnonanoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-981497", "l": "ST3GAL1-4 can add a sialic acid to the T antigen at the alpha 3 position (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17544", "l": "an aromatic primary alcohol + O2 <=> an aromatic aldehyde + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047612", "l": "acid-CoA ligase (GDP-forming) activity"}, {"i": "MetaCyc:ACID--COA-LIGASE-GDP-FORMING-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847880", "l": "CYTH proteins bind ARF1:GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57846", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sideretin (reduced form) => fraxetin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42157", "l": "3alpha-hydroxy-5alpha-androstan-17-one + H(+) + NADPH => 5alpha-androstane-3alpha,17beta-diol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58699", "l": "NADPH + O2 + rifampicin <=> H(+) + H2O + NADP(+) + rifampicin para-naphthoquinone carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23731", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 <=> A + H2O + prostaglandin H2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44578", "l": "2-all-trans-nonaprenylphenol + CO2 => 4-hydroxy-3-all-trans-nonaprenylbenzoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43746", "l": "AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2) => ATP + cytidine(34) in tRNA(Ile2) + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432556", "l": "Cytosolic PP2A dephosphorylates phosphorylated PER complexed with DCO (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10548", "l": "L-arginine + O2 = 4-guanidinobutanamide + CO2 + H2O"}, {"i": "EC:1.13.12.1", "l": "\"Arginine 2-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.219", "l": "\"Dihydroflavanol 4-reductase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047343", "l": "glucose-1-phosphate cytidylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102975", "l": "versiconal hemiacetal acetate reductase activity"}, {"i": "RHEA:35695", "l": "(3S)-versiconol acetate + NADP(+) = (2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50979", "l": "prostaglandin D2(out) <=> prostaglandin D2(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050124", "l": "N-acylneuraminate-9-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56824", "l": "AH2 + cyclooctat-9-ene-5,7-diol + O2 = A + cyclooctatin + H2O"}, {"i": "EC:1.14.99.62", "l": "\"Cyclooctatin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804425", "l": "TP53 binds POU4F2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734730", "l": "ORC1 translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050324", "l": "taurocyamine kinase activity"}, {"i": "MetaCyc:TAUROCYAMINE-KINASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40179", "l": "decanoyl-CoA + O2 = (2E)-decenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40833", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797090", "l": "CCNK binds CDK12 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093327", "l": "EPHA binds TIAM1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2106614", "l": "Duplex miRNA is loaded into Argonaute (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56228", "l": "(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphocholine = (9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061631", "l": "ubiquitin conjugating enzyme activity"}, {"i": "EC:2.3.2.23", "l": "\"E2 ubiquitin-conjugating enzyme\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58748", "l": "desmethylnectriapyrone + S-adenosyl-L-methionine = H(+) + nectriapyrone + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0000295", "l": "adenine nucleotide transmembrane transporter activity"}, {"i": "REACT:R-HSA-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15791", "l": "H(+) + L-xylono-1,4-lactone + NADPH => L-xylose + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31312", "l": "(2R)-3-phosphoglycerate + ADP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788622", "l": "p-Y-STATs dimerize (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33792", "l": "H2O + sucrose 6(F)-phosphate => beta-D-fructose + beta-D-glucose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55689", "l": "an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + H2O => 1D-myo-inositol 1-phosphate + an N-acyl-(4R)-4-hydroxysphinganine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993784", "l": "Conjugation of SUMO2 to UBA2:SAE1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33566", "l": "(4R)-hydroxysphinganine + ATP <=> (4R)-hydroxysphinganine 1-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21286", "l": "all-trans-retinal + H(+) + NADH => all-trans-retinol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19969", "l": "hydroxylamine + O2 = H(+) + H2O + nitrite"}, {"i": "EC:1.7.3.6", "l": "\"Hydroxylamine oxidase (cytochrome)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2046180", "l": "KSPG is secreted from the cell (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51653", "l": "D-mannonate + NAD(+) => H(+) + keto-D-tagaturonate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1220610", "l": "Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62678", "l": "6-thio-IMP + 7,8-dihydrofolate + H2O => 10-formyldihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102508", "l": "cyanidin 3,7-diglucoside glucosidase activity"}, {"i": "MetaCyc:RXN-14435"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58305", "l": "25-substituted-cholesterol + beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine => 25-substituted-cholesteryl beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30081", "l": "AMP + crotonobetainyl-CoA + diphosphate => ATP + CoA + crotonobetaine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28073", "l": "(2E,6E)-farnesyl diphosphate + H2O + heme b <=> diphosphate + Fe(II)-heme o"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14254", "l": "guanosine 3',5'-bis(diphosphate) + H2O => diphosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57315", "l": "H2O + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine <=> cytidine 5'-diphosphoramidate + H(+) + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54338", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64407", "l": "carnosine(out) + H(+)(out) <=> carnosine(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18886", "l": "GDP-beta-L-fucose + NADP(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981621", "l": "C3 convertases spontaneously dissociate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936731", "l": "Inactive BRAF mutants:mutant RAS:GTP bind RAF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17780", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1008200", "l": "NFE2 binds the beta globin locus control region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29062", "l": "2 H(+)(in) + H2 + ubiquinone-8 <=> 2 H(+)(out) + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.57", "l": "\"Taurochenodeoxycholate 6-alpha-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052705", "l": "methylhistidine N-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24568", "l": "a 6-phospho-beta-D-galactoside + H2O = an alcohol + D-galactose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56188", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031814", "l": "P2Y4 nucleotide receptor binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047298", "l": "(S)-3-amino-2-methylpropionate transaminase activity"}, {"i": "KEGG.REACTION:R04188"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58852", "l": "(6E)-8-oxogeraniol + NAD(+) = (6E)-8-oxogeranial + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102914", "l": "N-methyl-3-aminomethylindole N-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22029", "l": "acetyl-CoA + taxa-4(20),11-dien-5alpha-ol => CoA + taxa-4(20),11-dien-5alpha-yl acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043906", "l": "Ala-tRNA(Pro) hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14616", "l": "ATP + H2O + taurine(out) <=> ADP + H(+) + phosphate + taurine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654637", "l": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59541", "l": "(2R)-ethylmalonyl-CoA + H(+) => butanoyl-CoA + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31435", "l": "(2E,6E)-farnesyl diphosphate = (+)-alpha-santalene + diphosphate"}, {"i": "EC:4.2.3.82", "l": "\"Alpha-santalene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33785", "l": "1,6-kestotetraose + beta-D-glucose => 1(F)-beta-D-fructosylsucrose + sucrose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802942", "l": "RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48879", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O <=> L-seryl-[protein] + N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40652", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27537", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (3R,6E)-nerolidol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41755", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29489", "l": "cis-muurola-3,5-diene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18667", "l": "(2R)-3-phosphoglycerate + [phosphate](n+1) => (2R)-3-phospho-glyceroyl phosphate + [phosphate](n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201717", "l": "CSNK2-mediated phosphorylation of DVL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48539", "l": "1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O <=> 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16038", "l": "phosphate + thymidine => 2-deoxy-alpha-D-ribose 1-phosphate + thymine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018826", "l": "RHOT2 hydrolyzes GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623192", "l": "G6PC gene expression is stimulated by FOXO1,FOXO3,FOXO4,FOXO6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22816", "l": "D-xylose = D-xylulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18182", "l": "acetyl-CoA + glyoxylate + H2O => (S)-malate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679045", "l": "C-ter TLR9 dimer binds HCQ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050376", "l": "UDP-glucosamine 4-epimerase activity"}, {"i": "RHEA:23492", "l": "UDP-alpha-D-glucosamine = UDP-alpha-D-galactosamine"}, {"i": "EC:5.1.3.16", "l": "\"UDP-glucosamine 4-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061710", "l": "L-threonylcarbamoyladenylate synthase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975633", "l": "atROL binds to RBP2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25718", "l": "N-hydroxy-L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18813", "l": "(2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate = (3E,5R)-5-carboxy-2-oxohept-3-enedioate"}, {"i": "EC:5.3.3.10", "l": "\"5-carboxymethyl-2-hydroxymuconate Delta-isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9612509", "l": "SGK phosphorylates SRF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928625", "l": "PAKs autophosphorylate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34992", "l": "L-arginine(out) + L-ornithine(in) => L-arginine(in) + L-ornithine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53117", "l": "an 11beta-hydroxysteroid + NAD(+) => an 11-oxosteroid + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114264", "l": "Translocation of activated BAX to the mitochondria (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667657", "l": "NBEA binds NICD1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57944", "l": "H(+) + H2O2 + harderoheme III = CO2 + 2 H2O + heme b"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357828", "l": "RIPK1 is cleaved by CASP8 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003921", "l": "GMP synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66194", "l": "ADP + bilirubin-bisglucuronoside(out) + H(+) + phosphate => ATP + bilirubin-bisglucuronoside(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954056", "l": "E2F6 binds TFDP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50446", "l": "prostaglandin G3 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848774", "l": "PTK6 binds DOK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65878", "l": "1-hydroxy-5alpha-androstan-3,17-dione => 5alpha-androst-1-ene-3,17-dione + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8960973", "l": "RLBP1:11cRAL dissociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60901", "l": "a cytidine in RNA + S-adenosyl-L-methionine => an N(3)-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103064", "l": "inositol phosphorylceramide mannosyltransferase activity"}, {"i": "RHEA:64596", "l": "a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H(+)"}, {"i": "EC:2.4.1.370", "l": "\"Inositol phosphorylceramide mannosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35255", "l": "ATP + H2O + lipid A-core(in) = ADP + H(+) + lipid A-core(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30138", "l": "dodecanoyl-CoA + H2O <=> CoA + dodecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-349404", "l": "CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40741", "l": "(20S)-ginsenoside C-Y + 2 D-glucose => (20S)-ginsenoside Rb2 + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0016794", "l": "diphosphoric monoester hydrolase activity"}, {"i": "EC:3.1.7.-", "l": "\"Diphosphoric monoester hydrolases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60797", "l": "2 2-oxoglutarate + gibberellin A53 + H(+) + 3 O2 => 3 CO2 + gibberellin A20 + 2 H2O + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-994000", "l": "Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 upon TLR7 or 21 stimulation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.45", "l": "\"Homospermidine synthase (spermidine-specific)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675431", "l": "PP2A dephosphorylates RAF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1358791", "l": "Phosphorylation of USP8 by P-AKT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34895", "l": "ATP + H2O + selenite(out) = ADP + H(+) + phosphate + selenite(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26265", "l": "dehydroabietadienal + H2O + NADP(+) = dehydroabietate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140315", "l": "iron ion sequestering activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20215", "l": "L-lysyl-[glycine-cleavage complex H protein] + N(6)-octanoyl-L-lysyl-[lipoyl-carrier protein] => L-lysyl-[lipoyl-carrier protein] + N(6)-octanoyl-L-lysyl-[glycine-cleavage complex H protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23361", "l": "L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose => alpha-D-glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33294", "l": "L-pentahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-8-(methylsulfanyl)octanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13404", "l": "(2E,6E)-farnesol <=> (2Z,6E)-farnesol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140630", "l": "all-trans-phytoene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3244647", "l": "cGAS binds cytosolic DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4720432", "l": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983426", "l": "Capturing cargo and formation of prebudding complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676161", "l": "PI(3,5)P2 transports from the late endosome membrane to the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43748", "l": "ATP + CoA + hexacosanoate = AMP + diphosphate + hexacosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.287", "l": "\"D-arabinitol dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373342", "l": "CX3CR1 binds CX3CL1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12350", "l": "(4,5-dihydro-5-oxofuran-2-yl)-acetate => (S)-muconolactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203156", "l": "Platelet-derived TREM-1 ligand binds to TREM-1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008421", "l": "long-chain fatty-acyl-glutamate deacylase activity"}, {"i": "RHEA:17517", "l": "H2O + N-(long-chain-fatty-acyl)-L-glutamate = a long-chain fatty acid + L-glutamate"}, {"i": "EC:3.5.1.55", "l": "\"Long-chain-fatty-acyl-glutamate deacylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0032555", "l": "purine ribonucleotide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217147", "l": "Phosphorylation of c-Abl and Arg by ATM (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29358", "l": "dUMP + H2O <=> 2'-deoxyuridine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69005", "l": "Cdc6 protein is phosphorylated by CDK (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44282", "l": "4-hydroxy-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + 2 malonyl-CoA + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625426", "l": "Retrograde IFT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0035671", "l": "enone reductase activity"}, {"i": "MetaCyc:RXN-12267"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46340", "l": "ATP + N-hexadecanoylsphing-4-enine = ADP + H(+) + N-(hexadecanoyl)-sphing-4-enine-1-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070123", "l": "transforming growth factor beta receptor activity, type III"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602353", "l": "Defective IRAK4 variants do not bind MyD88:MAL:BTK:activated TLR2/4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15406", "l": "(3R)-3-hydroxybutanoyl-CoA + [(3R)-hydroxybutanoate](n) => [(3R)-hydroxybutanoate](n+1) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27478", "l": "2-oxoglutarate + O2 + thebaine => CO2 + formaldehyde + neopinone + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25750", "l": "L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109701", "l": "PDPK1 binds PIP3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29934", "l": "alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP <=> ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112430", "l": "Formation of P-TEFb complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948594", "l": "miR-19a microRNA binds VAPA mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55276", "l": "9-cis-retinol + tetradecanoyl-CoA = 9-cis-retinyl tetradecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-378956", "l": "Luteinizing hormone is a heterodimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46345", "l": "propanoyl-CoA + tetradecanoyl-CoA => 3-oxo-2-methylhexadecanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8934742", "l": "RUNX1 binds PRMT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65446", "l": "CoA + hexyl butanoate => butanoyl-CoA + hexan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451347", "l": "Activation of JNK by DSCAM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009976", "l": "tocopherol cyclase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848338", "l": "PNPLA4 hydrolyzes TAG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37776", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octanoyl-CoA => 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130504", "l": "Cleavage of lip22 to lip10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19687", "l": "CoA + H(+) + N-[(E)-feruloyl]tyramine => (E)-feruloyl-CoA + tyramine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031816", "l": "P2Y6 nucleotide receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54117", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + pseudolaratriene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853429", "l": "PHLDA1 binds AURKA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59684", "l": "D-maltohexaose + O2 = D-maltohexaono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54672", "l": "(+)-kolavenyl diphosphate + H2O = (+)-kolavelool + diphosphate"}, {"i": "EC:3.1.7.12", "l": "\"(+)-kolavelool synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12306", "l": "2 H(+) + L-2-aminoadipate + NADPH => (S)-2-amino-6-oxohexanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14904", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> casbene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39695", "l": "3-oxo-(13Z)-eicosenoyl-CoA + H(+) + NADPH = (R)-3-hydroxy-(13Z)-eicosenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1222491", "l": "Lactoferrin scavenges iron ions (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36846", "l": "(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173631", "l": "Activation of C1s (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68611", "l": "Formation of ORC(1-5) complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45389", "l": "H2O + N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-octadecanoyl-sn-glycero-3-phospho-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61784", "l": "L-allulose = keto-L-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50589", "l": "13,14-dihydro-15-oxo-PGF2alpha + NADP(+) => 15-oxoprostaglandin F2alpha + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17139", "l": "thromboxane A2 => prostaglandin H2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381608", "l": "cAMP activates EPAC2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416725", "l": "SEMA6D binds to PLXNA1:TREM2:DAP12 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27396", "l": "2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 <=> dichlorochromopyrrolate + H(+) + 2 H2O + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44859", "l": "(9Z)-octadecenoyl-CoA + (R)-carnitine <=> CoA + O-(9Z)-octadecenoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371591", "l": "Trimerization of cytosolic HSF1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44318", "l": "dodecanoate + glycerol + H(+) => 1-dodecanoylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56702", "l": "3-[(Z)-2-isocyanoethenyl]-1H-indole + 2 CO2 + H2O + succinate => (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15247", "l": "a fatty acid + glycerol + H(+) => a monoacylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610722", "l": "CK1 phosphorylates p-GLI3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932076", "l": "AXIN1 gene expression is inhibited by ESR1 and stimulated by RUNX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035241", "l": "protein-arginine omega-N monomethyltransferase activity"}, {"i": "RHEA:48100", "l": "L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.321", "l": "\"Type III protein arginine methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58106", "l": "(14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853429", "l": "PHLDA1 binds AURKA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29367", "l": "CMP + H2O = cytidine + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0070336", "l": "flap-structured DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654163", "l": "Activated FGFR4 binds PLCG1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18060", "l": "O2 + Watasenia luciferin <=> CO2 + hnu + oxidized Watasenia luciferin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13186", "l": "H2O + 4 porphobilinogen => hydroxymethylbilane + 4 NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37089", "l": "3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => [sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19866", "l": "4 H(+) + uroporphyrinogen III => 4 CO2 + coproporphyrinogen III"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008566", "l": "mitochondrial protein-transporting ATPase activity"}, {"i": "MetaCyc:3.6.3.51-RXN"}, {"i": "EC:7.4.2.3", "l": "\"Mitochondrial protein-transporting ATPase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44261", "l": "2 H(+) + hexadecanoyl-CoA + 2 malonyl-CoA => 4-hydroxy-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004414", "l": "homoserine O-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42084", "l": "9-cis-retinal + H2O + NAD(+) = 9-cis-retinoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51740", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A = a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate)"}]}
{"type": "biolink:MolecularActivity", "ic": "77.690207805941611", "identifiers": [{"i": "GO:1901681", "l": "sulfur compound binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23499", "l": "5-hydroxypentanoate + acetyl-CoA <=> 5-hydroxy-pentanoyl-CoA + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-169895", "l": "Crk's SH3 domain engages C3G (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16631", "l": "acetyl-CoA + glyoxylate => (S)-malyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18600", "l": "H(+) + NAD(+) + 2 reduced [rubredoxin] <=> NADH + 2 oxidized [rubredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696457", "l": "BDH2 dehydrogenates 3HBA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730858", "l": "Autophosphorylation of BTK/ITK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28300", "l": "(E)-gamma-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0019198", "l": "transmembrane receptor protein phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805205", "l": "GPR35 binds kynurenic acid (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21048", "l": "ATP + isopropylamine + L-glutamate = ADP + gamma-glutamyl-isopropylamide + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-265177", "l": "Exocyst complex formation (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32065", "l": "8-oxo-dGMP + H(+) + phosphate => 8-oxo-dGDP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46425", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57255", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP <=> glycolate + GTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52218", "l": "[(1''->2')-ADP-alpha-D-ribose]n-1 + ADP-D-ribose => [(1''->2')-ADP-alpha-D-ribose]n + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786789", "l": "FLT3LG dimer binds FLT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33427", "l": "(S)-malyl alpha-D-glucosaminide + L-cysteine = bacillithiol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55892", "l": "a 2-all-trans-polyprenylphenol + H(+) + NADPH + O2 = a 3-(all-trans-polyprenyl)benzene-1,2-diol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52194", "l": "(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-phenylacetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39760", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22245", "l": "kaempferol + UDP-alpha-D-xylose => H(+) + kaempferol 3-O-beta-D-xyloside + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0042171", "l": "lysophosphatidic acid acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637794", "l": "EGFRvIII does not bind CBL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "66.181106630879313", "identifiers": [{"i": "GO:0016838", "l": "carbon-oxygen lyase activity, acting on phosphates"}, {"i": "EC:4.2.3.-", "l": "\"Acting on phosphates\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1362416", "l": "Frataxin binds iron (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46775", "l": "1-octadecanoyl 2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694436", "l": "MIA2 and MIA3 dissociate from procollagen VII vesicle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40804", "l": "3,6-anhydro-alpha-L-galactopyranose + H2O + NADP(+) => 3,6-anhydro-L-galactonate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56788", "l": "apo-[corrinoid adenosyltransferase] + cob(II)alamin = cob(II)alamin--[corrinoid adenosyltransferase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58210", "l": "AH2 + alstonine => A + dihydroalstonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45403", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59301", "l": "3'-phosphoadenylyl sulfate + firefly D-luciferin => adenosine 3',5'-bisphosphate + firefly D-sulfoluciferin + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099609", "l": "microtubule lateral binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654651", "l": "Activated FGFR4 binds FRS3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626223", "l": "C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25300", "l": "acetate + 2 H(+) + NADPH => acetaldehyde + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42670", "l": "H(+) + L-rhamnono-1,4-lactone + NADPH => L-rhamnofuranose + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.41", "l": "\"(E)-2-methylbutanal oxime monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102520", "l": "L-threonine O-3-phosphate phosphatase activity"}, {"i": "MetaCyc:RXN-14505"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706354", "l": "Ubiquitination of FLT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031688", "l": "A2B adenosine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047720", "l": "indoleacetaldoxime dehydratase activity"}, {"i": "RHEA:23156", "l": "(E)-(indol-3-yl)acetaldehyde oxime = (indol-3-yl)acetonitrile + H2O"}, {"i": "EC:4.99.1.6", "l": "\"Indoleacetaldoxime dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381727", "l": "RAP1A exchanges GDP for GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18923", "l": "cholesta-5,7-dien-3beta-ol + 2 H2O + NAD(+) => 5alpha-cholest-7-en-3beta-ol + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158164", "l": "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694331", "l": "nsp3-4 is glycosylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59223", "l": "(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O <=> (2Z)-2-hydroxypenta-2,4-dienoate + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047036", "l": "codeinone reductase (NADPH) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21552", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072371", "l": "histone kinase activity (H2A-S121 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61400", "l": "ATP + N(6)-(D-ribulosyl)-L-lysine = ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018645", "l": "alkene monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41178", "l": "[Co(I) dimethylamine-specific corrinoid protein] + dimethylamine + H(+) <=> [methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59116", "l": "[protein]-dithiol + O2 = [protein]-disulfide + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2509838", "l": "ITPA hydrolyses dITP to dIMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27958", "l": "cytidine + H2O = cytosine + D-ribose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14461", "l": "(25S)-5beta-spirostan-3beta-ol + UDP-alpha-D-glucose = (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP"}, {"i": "EC:2.4.1.193", "l": "\"Sarsapogenin 3-beta-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27439", "l": "glutathione amide disulfide + 2 H2O => 2 glutathione amide + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40753", "l": "1-(9Z)-octadecenoylglycerone 3-phosphate + hexadecanoate => (9Z)-octadecenoate + 1-hexadecanoylglycerone 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-448744", "l": "IL20RA binds IL20RB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51991", "l": "(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O <=> 18S-resolvin E1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32982", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O <=> a fatty acid + H(+) + sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375131", "l": "Basigin binds CD98 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102435", "l": "myricetin 7-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-13910"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8870465", "l": "RGGT binds the RAB-binding subunit (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936963", "l": "IRAK2 induces TRAF6 oligomerization (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48905", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508451", "l": "PTK2B is phosphorylated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47099", "l": "(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate <=> (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36194", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + choline <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191763", "l": "snRNP:Snurportin complex formation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803801", "l": "TP53 in complex with ZNF385A binds the CDKN1A promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786190", "l": "CMBL hydrolyses OM to OLMS (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22235", "l": "H(+) + NADPH + presqualene diphosphate <=> diphosphate + NADP(+) + squalene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36767", "l": "2-hydroxytetracosenoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxytetracosenoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14202", "l": "D-lyxose => D-xylulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849102", "l": "SRMS phosphorylates PTK6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32026", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> avermitilol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64976", "l": "8-oxo-dGTP + 2 H2O = 8-oxo-dGMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21807", "l": "ATP + myo-inositol <=> 1D-myo-inositol 3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41364", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19404", "l": "methanol + NAD(+) <=> formaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44587", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-(1'-sn-glycerol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66587", "l": "3-oxocholestane + A + H2O <=> 25-hydroxy 3-oxocholestane + AH2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047375", "l": "N-acetylgalactosaminoglycan deacetylase activity"}, {"i": "MetaCyc:3.1.1.58-RXN"}, {"i": "EC:3.1.1.58", "l": "\"N-acetylgalactosaminoglycan deacetylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22153", "l": "a ubiquinone + D-glucose => a ubiquinol + D-glucono-1,5-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.4"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033974", "l": "nucleoside phosphoacylhydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5656070", "l": "FGFBPs bind FGFs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38851", "l": "H(+) + tetracenomycin F2 = H2O + tetracenomycin F1"}, {"i": "EC:4.2.1.154", "l": "\"Tetracenomycin F2 cyclase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29046", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH <=> (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55505", "l": "(5S,9S,10S)-drim-7-en-11-ol + O2 + reduced [NADPH--hemoprotein reductase] => (5S,10S)-(9R)-7-drimene-11,12-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10989", "l": "H2O + nitrous oxide => 2 e(-) + 2 H(+) + 2 nitric oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357445", "l": "PAK1-3 dimer disassociates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35571", "l": "(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] = (1'S,5'S)-5'-hydroxyaverantin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27806", "l": "acetoacetate + acetyl-CoA = acetate + acetoacetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66263", "l": "CoA + IC-asc-C7-AMP <=> AMP + H(+) + IC-asc-C7-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912503", "l": "Formation of meiotic single-stranded DNA invasion complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48838", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625416", "l": "Anterograde IFT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75891", "l": "Abortive Initiation After Second Transition (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21091", "l": "2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2 <=> a flavonol + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34665", "l": "3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine => 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30393", "l": "2-oxoglutaramate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166286", "l": "Multiple IRAK1 autophosphorylation steps (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015361", "l": "low-affinity sodium:dicarboxylate symporter activity"}, {"i": "REACT:R-HSA-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647660", "l": "GSDME (1-270) binds PIPs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351876", "l": "Caspase-mediated cleavage of occludin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63724", "l": "candesartan + UDP-alpha-D-glucuronate = candesartan O-beta-D-glucuronoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13400", "l": "6-oxohexanoate + H2O + NADP(+) <=> 2 H(+) + hexanedioate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627107", "l": "XIAP binds CASP7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936963", "l": "IRAK2 induces TRAF6 oligomerization (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15770", "l": "adenosylcob(III)inamide + ATP => adenosylcob(III)inamide phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099567", "l": "calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710101", "l": "CASP4, CASP5 cleave GSDMD (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.8.15", "l": "\"3-(aryl)acrylate reductase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102214", "l": "omega-hydroxy fatty acyl-CoA synthetase activity"}, {"i": "MetaCyc:RXN-12185"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390184", "l": "YKI binds to SD and activates transcription (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42722", "l": "2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2552) in 23S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42648", "l": "(2,5-ethylene furandicarboxylate)(n) + 2 H2O = (2,5-ethylene furandicarboxylate)(n-1) + 2,5-dicarboxyfuran + ethylene glycol + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8858475", "l": "TNFSF9 binds TNFRSF9 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36357", "l": "4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine => 4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35327", "l": "eicosanoyl-CoA + H(+) + malonyl-CoA = 3-oxodocosanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13356", "l": "4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol <=> 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709406", "l": "CO binds to Cytochrome c oxidase (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114553", "l": "Activation of conventional Protein Kinase C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27511", "l": "7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine => dehydro coenzyme F420-0 + GMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54862", "l": "(1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + H2O + NADP(+) => (2E)-geranial + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39945", "l": "a 1,2-diacylglycerol + CoA => a 1-acylglycerol + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15021", "l": "(E)-feruloyl-CoA + L-quinate = 4-O-feruloyl-D-quinate + CoA"}, {"i": "EC:2.3.1.99", "l": "\"Quinate O-hydroxycinnamoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848250", "l": "ACBD6 binds LCFA-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168883", "l": "Haptoglobin:Hemoglobin binds CD163 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34413", "l": "cannabidiolate + H2O2 => cannabigerolate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16754", "l": "Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADPH + O2 => 3,8-divinyl protochlorophyllide a + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043530", "l": "adenosine 5'-monophosphoramidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19331", "l": "H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP => nuatigenin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375384", "l": "Bombesin-like receptors bind bombesin homologues (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694583", "l": "ABHD4 hydrolyses NAPE (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-398184", "l": "LARG activation by G alpha 12/13 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52251", "l": "6 H2O + 4 Mn(3+) + O2 <=> 12 H(+) + 4 MnO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30417", "l": "formate + H2O + heptadecane + 2 NADP(+) => H(+) + 2 NADPH + O2 + octadecanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53372", "l": "5,6-dihydrouridine(17) in tRNA + NAD(+) = H(+) + NADH + uridine(17) in tRNA"}, {"i": "EC:1.3.1.88", "l": "\"tRNA-dihydrouridine(16/17) synthase (NAD(P)(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3296301", "l": "CCRL2 binds CCL19 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12615", "l": "glutathione disulfide + 2 L-cysteine => 2 glutathione + L-cystine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60183", "l": "ATP + D-fructose(out) + H2O <=> ADP + D-fructose(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.65"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40146", "l": "(9Z,12Z)-octadecadienoyl-CoA + H2O <=> (9Z,12Z)-octadecadienoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46626", "l": "a L-5-monosubstituted hydantoin => a D-5-monosubstituted hydantoin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446194", "l": "Addition of a third glucose to the N-glycan precursor by an ALG10 homologue (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167633", "l": "Formation of Nef:Cd28:Clathrin-coated Pit Adapter Protein complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621386", "l": "TRIB1 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53655", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77077", "l": "Capping complex formation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000310", "l": "AURKA phosphorylates PLK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58125", "l": "(19S)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + polyneuridine aldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703441", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1028820", "l": "Formation of VAF (virus-activated factor) complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657641", "l": "ALKBH2 binds alkylated DNA containing 1-meA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36658", "l": "desmethyldescarbamoylnovobiocin + S-adenosyl-L-methionine <=> descarbamoylnovobiocin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5658435", "l": "RAS GAPs bind RAS:GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2172678", "l": "PHF8 demethylates histone H4K20me1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199518", "l": "C3d-complexed antigen binds to complement receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050590", "l": "desacetoxyvindoline 4-hydroxylase activity"}, {"i": "RHEA:18973", "l": "2-oxoglutarate + deacetoxyvindoline + O2 = 4-O-deacetylvindoline + CO2 + succinate"}, {"i": "RHEA:24865", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + 2-oxoglutarate + O2 = 4-O-deacetyl-16-O-demethylvindoline + CO2 + succinate"}, {"i": "EC:1.14.11.20", "l": "\"Deacetoxyvindoline 4-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8865774", "l": "TTLLs polyglutamylate tubulin (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445704", "l": "Calcium Binds Caldesmon (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65087", "l": "asperaculane E + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> aculene D + CO2 + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32373", "l": "all-trans-zeaxanthin + 2 H2O + 2 L-dehydroascorbate => all-trans-violaxanthin + 2 L-ascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22247", "l": "kaempferol + UDP-alpha-D-xylose <=> H(+) + kaempferol 3-O-beta-D-xyloside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28437", "l": "(9Z)-hexadecenoyl-(Kdo)2-lipid IVA + tetradecanoyl-[ACP] <=> ((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-376887", "l": "2-oxoglutarate [mitochondrial matrix] + malate [cytosol] <=> 2-oxoglutarate [cytosol] + malate [mitochondrial matrix] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21621", "l": "FMNH2 + NAD(+) => FMN + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64358", "l": "(3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H(+) + 2 H2O => 2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0008428", "l": "ribonuclease inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15867", "l": "4-hydroxytryptamine + A + H2O => AH2 + O2 + tryptamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664271", "l": "Release of PLCG from FCGR3A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1474266", "l": "Formation of collagen fibrils (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451942", "l": "Within the IL-2R complex JAK3 phosphorylates JAK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030591", "l": "2'-deoxyguanosine DNA ADP-ribosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444527", "l": "FPR is a receptor for formyl peptides (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806732", "l": "GNLY binds the bacterial cell surface (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031787", "l": "H9 melatonin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9604328", "l": "AKT1 phosphorylates NOTCH4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40214", "l": "(3S)-hydroxytetradecanedioyl-CoA + NAD(+) <=> 3-oxotetradecanedioyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10112", "l": "L-homocysteine + L-serine = H2O + L,L-cystathionine"}, {"i": "EC:4.2.1.22", "l": "\"Cystathionine beta-synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22218", "l": "3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+) => (E)-caffeate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56935", "l": "androst-5-en-3beta,17beta-diol + NAD(+) <=> 17beta-hydroxy-androst-5-en-3-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.25", "l": "\"tRNA-uridine aminocarboxypropyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49806", "l": "FMN + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine => 2-methylpropan-1-amine + FMNH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50085", "l": "ATP + H2O + taurolithocholate 3-sulfate(in) => ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043915", "l": "L-seryl-tRNA(Sec) kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23533", "l": "ATP + cholate + CoA => AMP + choloyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52487", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + A <=> (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35300", "l": "3-hydroxyoctadecanoyl-CoA + NADP(+) => 3-oxooctadecanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34335", "l": "cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 22R-hydroxycholesterol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878056", "l": "RUNX1:CBFB binds EP300 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50287", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9639286", "l": "RRAGC,D exchanges GTP for GDP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451900", "l": "IL2RB binds JAK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018814", "l": "phenylacetaldoxime dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37188", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3-phosphate => 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.3.19"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21716", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + (S)-mandelate + O2 = (6R)-L-erythro-6,7-dihydrobiopterin + (S)-4-hydroxymandelate + H2O"}, {"i": "EC:1.14.16.6", "l": "\"Mandelate 4-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16744", "l": "a 2-acylglycerol + an acyl-CoA <=> a 1,2-diacylglycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797803", "l": "PTPRD binds SLITRK1-6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29107", "l": "H(+) + NADH + ubiquinone-8 = NAD(+) + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5622129", "l": "FABP5 binds atRA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050451", "l": "CoA-disulfide reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164524", "l": "Fusion of viral membrane with host cell membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54208", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25849", "l": "(1S,5S)-carveol + NAD(+) => (S)-carvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372529", "l": "Release of acetylcholine at the synapse (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617828", "l": "TRIP11:IFT20 dissociates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31565", "l": "L-glutamate + leukotriene D4 => H2O + leukotriene C4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909718", "l": "Formation of p-STAT1 homodimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45739", "l": "(3E)-hexenoyl-CoA <=> (2E)-hexenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0098809", "l": "nitrite reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58825", "l": "4 H(+) + luteothin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => aureothin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55516", "l": "11-hydroxycucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] = 11-oxocucurbitadienol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51690", "l": "H(+) + keto-L-tagatose + NADH => galactitol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982617", "l": "CYGB:O2 dissociates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018807", "l": "RAC3 GDIs block activation of RAC3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665982", "l": "RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102039", "l": "alkylhydroperoxide reductase activity"}, {"i": "RHEA:62628", "l": "a hydroperoxide + H(+) + NADH = an alcohol + H2O + NAD(+)"}, {"i": "MetaCyc:R4-RXN"}, {"i": "EC:1.11.1.26", "l": "\"NADH-dependent peroxiredoxin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22419", "l": "3,4-dihydroxybenzoate + H(+) <=> catechol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63347", "l": "ATP + L-amino acyl-L-threonyl-[protein] <=> (S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22091", "l": "ATP + GTP <=> AMP + guanosine 3'-diphosphate 5'-triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354097", "l": "Activation of Talin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8934742", "l": "RUNX1 binds PRMT1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35345", "l": "3-oxodocosanoyl-CoA + H(+) + NADPH => 3-hydroxydocosanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62376", "l": "2,4-didehydro-3-deoxy-L-rhamnonate + H2O = (S)-lactate + H(+) + pyruvate"}, {"i": "EC:3.7.1.26", "l": "\"2,4-didehydro-3-deoxy-L-rhamnonate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65703", "l": "chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] <=> cholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50012", "l": "H(+) + NADPH + O2 + tert-butanol = 2-methylpropane-1,2-diol + H2O + NADP(+)"}, {"i": "EC:1.14.13.229", "l": "\"Tert-butanol monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354060", "l": "Translocation of RIAM to plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209573", "l": "p75NTR:NgR complex interacts with the axonal inhibitor LINGO1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810843", "l": "Envoplakin binds periplakin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682020", "l": "MRN complex binds shortened telomeres (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55858", "l": "all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54457", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O => 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015228", "l": "coenzyme A transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25734", "l": "H(+) + N,N-dihydroxy-L-tetrahomomethionine <=> (E)-7-(methylsulfanyl)heptanal oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0044183", "l": "protein folding chaperone"}, {"i": "REACT:R-HSA-9018785", "l": "RHOBTB2 binds GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47433", "l": "(7Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61282", "l": "H2O2 + NH4(+) + succinate semialdehyde => 4-aminobutanoate + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48984", "l": "(2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2 = 2,4-dichlorophenol + CO2 + glyoxylate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37691", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.25", "l": "\"Beta-peptidyl aminopeptidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033929", "l": "blood-group-substance endo-1,4-beta-galactosidase activity"}, {"i": "MetaCyc:3.2.1.102-RXN"}, {"i": "EC:3.2.1.102", "l": "\"Blood-group-substance endo-1,4-beta-galactosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16772", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 1-phosphate <=> (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64717", "l": "NADP(+) + propanal => acrolein + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34423", "l": "(-)-secoisolariciresinol + NADP(+) = (+)-lariciresinol + H(+) + NADPH"}, {"i": "EC:1.23.1.2", "l": "\"(+)-lariciresinol reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373738", "l": "Neurofascin interacts with syntenin-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12891", "l": "3-dehydro-L-gulonate + H(+) + NADH => L-gulonate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15100", "l": "5-formimidoyltetrahydrofolate + L-glutamate <=> (6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700168", "l": "Active ALK phosphorylates IRS1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015147", "l": "L-arabinose transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64932", "l": "dGTP + 2 H2O = dGMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48583", "l": "[pyruvate, water dikinase]-phosphate + H(+) + phosphate <=> [pyruvate, water dikinase] + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682598", "l": "ATM phosphorylates HERC2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10401", "l": "L-glutamine + pyruvate => 2-oxoglutaramate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13594", "l": "allantoate + 2 H(+) + H2O => CO2 + NH4(+) + ureidoglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57085", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O => a fatty acid + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10788", "l": "2-dehydro-D-gluconate + ATP = 6-phospho-2-dehydro-D-gluconate + ADP + H(+)"}, {"i": "EC:2.7.1.13", "l": "\"Dehydrogluconokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49044", "l": "H(+) + NADH + O2 + protoasukamycin = 4-hydroxyprotoasukamycin + H2O + NAD(+)"}, {"i": "EC:1.14.13.215", "l": "\"Protoasukamycin 4-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64597", "l": "a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose => an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17982", "l": "4,5alpha-dihydrocortisone + NADP(+) => cortisone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.116", "l": "\"Averantin hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49857", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49738", "l": "CO2 + deoxyviolacein + 2 H2O + NAD(+) => 2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798268", "l": "TP53 and E2F4 inhibit CDC25C expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45382", "l": "(4R)-hydroxysphinganine + (5Z,8Z,11Z,14Z)-eicosatetraenoate => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429415", "l": "SYK binds to integrin alphaIIb beta3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165195", "l": "GTP loading by Rheb (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66074", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-leucine => 4-methyl-2-oxopentanoate + L-kynurenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381668", "l": "cAMP activates EPAC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39130", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+) <=> 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30341", "l": "CO2 + tryptamine => H(+) + L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858252", "l": "HDLBP binds HDL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16032", "l": "3-guanidinopropanoate + H2O <=> beta-alanine + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.78", "l": "\"Phosphopolyprenol glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.99.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444202", "l": "Receptor FFAR1 binds free fatty acids (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14226", "l": "6-hydroxyhexanoate + NAD(+) => 6-oxohexanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090416", "l": "nicotinate transmembrane transporter activity"}, {"i": "REACT:R-HSA-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23806", "l": "N-acetyl-D-glucosamine 6-phosphate => N-acetyl-alpha-D-glucosamine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63929", "l": "2 [Fe(II)-cytochrome b5] + an N-acylsphing-4-enine + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + an N-acyl-sphinga-4E,14Z-dienine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37258", "l": "A + D-asparagine + H2O <=> 2-oxosuccinamate + AH2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32117", "l": "CO2 + succinate + TRIBOA beta-D-glucoside => 2-oxoglutarate + DIBOA beta-D-glucoside + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10718", "l": "1D-myo-inositol 3-phosphate => D-glucose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51496", "l": "a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+)"}, {"i": "EC:2.7.1.91", "l": "\"Sphingosine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65266", "l": "AH2 + chrodrimanin C => 3-hydroxypentacecilide A + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17697", "l": "pyridine + thiamine = 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine"}, {"i": "EC:2.5.1.2", "l": "\"Thiamine pyridinylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0017116", "l": "single-stranded DNA helicase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964311", "l": "G alpha (i):GTP binds SRC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35264", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6795290", "l": "TORC2 complex phosphorylates SGK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35880", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21046", "l": "(Z)-24-ethylidenelophenol + H(+) + S-adenosyl-L-homocysteine => 24-methylidenelophenol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25540", "l": "ent-copalyl diphosphate = diphosphate + ent-pimara-8(14),15-diene"}, {"i": "EC:4.2.3.30", "l": "\"Ent-pimara-8(14),15-diene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683606", "l": "Nucleoprotein translocates to the nucleolus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45642", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36798", "l": "a ribonucleoside 5'-triphosphate + 2 H2O <=> a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809565", "l": "I(1,3)P2 is dephosphorylated into I1P by MTMR7:MTMR9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047656", "l": "alpha,alpha-trehalose phosphorylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5683774", "l": "p-T68-CHEK2 dimerizes (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24100", "l": "diisopropyl fluorophosphate + H2O = diisopropyl phosphate + fluoride + 2 H(+)"}, {"i": "EC:3.1.8.2", "l": "\"Diisopropyl-fluorophosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64146", "l": "(9Z)-octadecenoate + L-methionine => H2O + N-(9Z-octadecenoyl)-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43075", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> erythrodiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59174", "l": "AMP + H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] => hexadecanoyl-AMP + holo-[(hydroxy)phthioceranic acid synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44743", "l": "27-O-demethylrifamycin SV + S-adenosyl-L-methionine <=> H(+) + rifamycin SV + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-984733", "l": "Kinesin-3 is a dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33816", "l": "CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate => 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004704", "l": "NF-kappaB-inducing kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45420", "l": "H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine = a fatty acid + H(+) + N-acyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43786", "l": "H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine => adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10689", "l": "H2O + streptomycin 6-phosphate => phosphate + streptomycin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48891", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione <=> (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11809", "l": "bergaptol + S-adenosyl-L-methionine => bergapten + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22233", "l": "H(+) + NADPH + presqualene diphosphate => diphosphate + NADP(+) + squalene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41681", "l": "a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+) => a 2-all-trans-polyprenylphenol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23027", "l": "[(1->4)-beta-D-glucosyl](n) + phosphate <=> [(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46737", "l": "H2O + monoacyl-sn-glycero-3-phosphate => a monoacylglycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33587", "l": "acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate = CoA + H(+) + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate"}, {"i": "EC:2.3.1.201", "l": "\"UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52541", "l": "cytidine + phosphate => alpha-D-ribose 1-phosphate + cytosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018808", "l": "RAC3 binds effectors at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.-", "l": "\"Transferases for other substituted phosphate groups\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83650", "l": "FasL:Fas binds FADD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39358", "l": "(2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H(+) + NADPH <=> (11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709547", "l": "ESTG binds ESR2:chaperone complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047042", "l": "androsterone dehydrogenase (B-specific) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64771", "l": "S-3-(hexan-1-ol)-L-cysteine <=> 2-aminoprop-2-enoate + 3-sulfanyl-1-hexanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-451418", "l": "Pellino ubiquitinates IRAK1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39399", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA = (2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646347", "l": "PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38673", "l": "sphinganine 1-phosphate(out) => sphinganine 1-phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48227", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O <=> a neolactoside nLc4Cer(d18:1(4E)) + L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34344", "l": "(20R,22R)-20,22-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 4-methylpentanal + 2 H2O + 2 oxidized [adrenodoxin] + pregnenolone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55946", "l": "2 [Fe(II)cytochrome c] + chloroacetaldehyde + 2 H(+) => 2-chloroethanol + 2 [Fe(III)cytochrome c]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33195", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47404", "l": "(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) = 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15853", "l": "17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(+) = 17alpha-hydroxyprogesterone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120319", "l": "long-chain fatty acid omega-1 hydroxylase activity"}, {"i": "RHEA:60936", "l": "an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an (omega-1)-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10918", "l": "all-trans-phytoene + diphosphate => (1R,2R,3R)-prephytoene diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20976", "l": "a primary nitroalkane + H2O + O2 = an aldehyde + H(+) + H2O2 + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549304", "l": "OCT3 mediates renal clearance of organic cations (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50126", "l": "8-oxoresolvin D1 + H(+) + NADH => NAD(+) + resolvin D1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30969", "l": "9,9'-di-cis-zeta-carotene => 9,9',15-tri-cis-zeta-carotene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62117", "l": "H2O + iminosuccinate => NH4(+) + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27630", "l": "ethylene glycol + NAD(+) = glycolaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665413", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR recruit GRB2:SOS1 through SHC1  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45609", "l": "H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15236", "l": "[Fe(III)cytochrome c] + H2O + nitric oxide <=> [Fe(II)cytochrome c] + 2 H(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690701", "l": "SHP1 binds p-CD22 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-593685", "l": "Netrin-4 binds DCC/UNC5A (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14355", "l": "CO2 + L-xylulose 5-phosphate => 3-dehydro-L-gulonate 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17376", "l": "all-trans-antheraxanthin <=> all-trans-capsanthin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30240", "l": "n a quinone + n H(+) + n hydrogen sulfide => n a quinol + n sulfur"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3364014", "l": "Recruitment of SET1 methyltransferase complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8986258", "l": "SLIT2:ROBO1 binds CXCR4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13250", "l": "(R)-2-hydroxypropyl-coenzyme M + NAD(+) => 2-oxopropyl-coenzyme M + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31921", "l": "3-hydroxyindolin-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => indolin-2-one + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11630", "l": "an aldehyde + CO2 => a 2-oxocarboxylate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198270", "l": "PDPK1 phosphorylates AKT at T308 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66020", "l": "H2O2 + L-lysyl-[collagen] + L-methionyl-[collagen] = [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.119"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358789", "l": "Self-ubiquitination of RNF41 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106340", "l": "tRNA (guanosine 32-2'-O)-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429955", "l": "CCR4-NOT complex deadenylates mRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52186", "l": "1-aci-nitro-2-(1H-indol-3-yl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (E)-(indol-3-yl)acetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28508", "l": "4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP + H(+) => alpha-Kdo-(2->6)-lipid IVA + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848436", "l": "PTK6 phosphorylates CDKN1B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12738", "l": "5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine => [PrdC protein]-L-selenocysteine/L-cysteine + D-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4839634", "l": "CTNNB1 S33 mutants aren't phosphorylated by GSK3beta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389954", "l": "Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604712", "l": "Initial activation of proMMP7 by trypsin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:1901478", "l": "aminotriazole transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2314678", "l": "Aspirin acetylates PTGS1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61642", "l": "benzoyl-CoA + CO2 => H(+) + isophthalyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445448", "l": "HHIP binds Hedgehog (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607721", "l": "Activation of NIK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374337", "l": "Apelin receptor binds to apelin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28814", "l": "2,3-dioxo-L-gulonate(in) + Na(+)(in) <=> 2,3-dioxo-L-gulonate(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5688797", "l": "ATXN3 family cleave Ub chains (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17491", "l": "cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) => H(+) + NADH + O2 + phthalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783681", "l": "LIF binds LIFR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11842", "l": "benzoate + 2 H(+) + NADH => benzaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41165", "l": "1-O-hexadecyl-2-desoxy-2-amino-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-2-amino-sn-glycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-984689", "l": "Kinesin-7 is a dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24920", "l": "L-homoserine => 2-aminobut-2-enoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202726", "l": "F11R dimerises (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65685", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontadienoyl)-sphing-4-enine => a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontadienoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174235", "l": "Association of Emi1 with Cdc20 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433608", "l": "ceramide + H2O => stearate + sphingosine [endoplasmic reticulum] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28785", "l": "glycine + L-cysteine => H2O + L-cysteinylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805943", "l": "S100A1 binds TLR4:LY96 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65117", "l": "2-oxoglutarate + aculene B + O2 => aculene A + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60809", "l": "gibberellin A19 + H(+) + O2 => CO2 + gibberellin A20 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399939", "l": "Autophosphorylation of PAK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047706", "l": "biochanin-A reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983285", "l": "RAD51B binds RAD51C (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426163", "l": "SREBP1A,2 binds the CYP51A1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34384", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + UDP-alpha-D-galactofuranose => beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654422", "l": "Activated FGFR4 binds FRS2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008730", "l": "L(+)-tartrate dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31437", "l": "(+)-alpha-santalene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672304", "l": "IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.14", "l": "\"Aromatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213244", "l": "Loading of antigenic peptides (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170846", "l": "TGFBR2 recruits TGFBR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940100", "l": "CDK1 phosphorylates VCPIP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27337", "l": "2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin] = 15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin]"}, {"i": "EC:1.14.15.8", "l": "\"Steroid 15-beta-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48681", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) => a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43971", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30174", "l": "hexadecanoyl-[ACP] + sn-glycerol 3-phosphate <=> 1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35663", "l": "a 1,2-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417843", "l": "P2Y13 binds ADP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51729", "l": "dihydroxyacetone phosphate + H2O => dihydroxyacetone + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.89", "l": "\"Signal peptidase I\""}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0005506", "l": "iron ion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964759", "l": "Alternative endo-mannosidase I route (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66639", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (-)-alpha-acorenol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424485", "l": "Release of p-PLCG1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031815", "l": "P2Y5 nucleotide receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46141", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 22R-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64320", "l": "(9Z)-hexadecenoyl-CoA + cholesterol = cholesteryl (9Z)-hexadecenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004723", "l": "calcium-dependent protein serine/threonine phosphatase activity"}, {"i": "REACT:R-HSA-2025882", "l": "Calcineurin dephosphorylates NFATC1,2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683634", "l": "Dimerisation of nucleoprotein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019894", "l": "kinesin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862084", "l": "PILRA,PILRB bind CD99 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797961", "l": "CHDH oxidises Cho to BETALD (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58518", "l": "15alpha-stemmadenine intermediate I + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (19S)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34826", "l": "(E)-feruloyl-CoA + (E)-feruloylacetyl-CoA + H2O <=> CO2 + 2 CoA + curcumin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36932", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 => (9Z)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51879", "l": "2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate <=> desmethylxanthohumol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18162", "l": "acetyl-CoA + tetradecanoyl-CoA => 3-oxohexadecanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20810", "l": "CoA + N-acetyl-7-O-acetylneuraminate => acetyl-CoA + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25451", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-guaia-6,9-diene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684261", "l": "MAP3K8 is phosphorylated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63220", "l": "7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA + S-adenosyl-L-methionine = 5'-deoxyadenosine + archaeosine(15) in tRNA + 2 H(+) + L-1-piperideine-6-carboxylate + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60133", "l": "a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 => a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64154", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP + H(+) => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP-N-acetyl-beta-neuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19862", "l": "a 16alpha-hydroxysteroid + NAD(+) => a 16-oxosteroid + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015643", "l": "toxic substance binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199144", "l": "Nectin 2 binds CD226 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55468", "l": "11-hydroxyferruginol + O2 + reduced [NADPH--hemoprotein reductase] = 11,20-dihydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20086", "l": "a flavonol 3-O-beta-D-glucoside + malonyl-CoA => a flavonol 3-O-(6-O-malonyl-beta-D-glucoside) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55941", "l": "all-trans-3,4-didehydroretinol + NAD(+) => all-trans-3,4-didehydroretinal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682010", "l": "ATG10:ATG12 binds ATG5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66384", "l": "(2E,6E,10E,14E)-geranylfarnesol = scalar-17(25)-en-19-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939204", "l": "ESTG binds ESR1:chaperone complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58229", "l": "L-asparaginyl-[protein] + NAD(+) => H(+) + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50111", "l": "hexadecanoyl-CoA + taurine <=> CoA + H(+) + N-hexadecanoyl-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691167", "l": "CUL1, SKP1, FBXL5 bind (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56604", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392064", "l": "G alpha (z) inhibits adenylate cyclase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350745", "l": "Release of Calumenin  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937613", "l": "CRHBP binds CRH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51666", "l": "H(+) + N-carbamoyl-D-phenylglycine => D-5-phenylhydantoin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10534", "l": "D-glyceraldehyde 3-phosphate + H2O + L-tryptophan => (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975594", "l": "PLB1 hydrolyses RPALM to atROL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9670014", "l": "Factor VIIIa dissociates  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26034", "l": "2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3,3'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65324", "l": "acetyl-CoA + chrodrimanin A = chrodrimanin B + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198563", "l": "IDO1 dioxygenates L-Trp to NFK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905573", "l": "ganglioside GM1 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32141", "l": "AMP + diphosphate + malonyl-CoA => ATP + CoA + malonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190258", "l": "FGFR2c binds to FGF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19829", "l": "a primary alcohol + O2 = an aldehyde + H2O2"}, {"i": "EC:1.1.3.13", "l": "\"Alcohol oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63993", "l": "5-fluorocytidine + ATP => 5-fluorocytidine 5'-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45039", "l": "3 [Fe(III)cytochrome c] + hydroxylamine <=> 3 [Fe(II)cytochrome c] + 3 H(+) + nitric oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43310", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1-hexadecanoyl-sn-glycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47792", "l": "cytidine(4447) in 28S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(4447) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43415", "l": "a D-galactosylceramide + H2O <=> an N-acyl-sphingoid base + D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369115", "l": "SHP2 is phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18769", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate = 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate"}, {"i": "EC:5.3.2.5", "l": "\"2,3-diketo-5-methylthiopentyl-1-phosphate enolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34375", "l": "4-guanidinobutanamide + H2O = 4-guanidinobutanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4655374", "l": "SUMOylation of DNMT3B with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33388", "l": "cadaverine + S-adenosyl 3-(methylsulfanyl)propylamine => aminopropylcadaverine + H(+) + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937864", "l": "RUNX2 binds tyrosine phosphorylated YAP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429694", "l": "CERT:PPM1L:VAPA/B [ER] => CERT [cytosol] + PPM1L:VAPA/B [ER] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59099", "l": "monoglucosyl-enterobactin + UDP-alpha-D-glucose <=> diglucosyl-enterobactin + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40493", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) => 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018794", "l": "RHOV binds effectors at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004064", "l": "arylesterase activity"}, {"i": "MetaCyc:ARYLESTERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37928", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62140", "l": "dTMP + GTP = dTDP + GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008460", "l": "dTDP-glucose 4,6-dehydratase activity"}, {"i": "RHEA:17221", "l": "dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O"}, {"i": "EC:4.2.1.46", "l": "\"dTDP-glucose 4,6-dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33322", "l": "a 1-acyl-sn-glycero-3-phosphate + octadecanoyl-CoA <=> a 1-acyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139895", "l": "tBID activates BAK protein (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42700", "l": "6-carboxyhexanoyl-[ACP] methyl ester + H2O = 6-carboxyhexanoyl-[ACP] + H(+) + methanol"}, {"i": "EC:3.1.1.85", "l": "\"Pimeloyl-[acyl-carrier protein] methyl ester esterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33287", "l": "A + spermidine = 1-pyrroline + AH2 + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.18.8", "l": "\"7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009042", "l": "valine-pyruvate transaminase activity"}, {"i": "RHEA:22912", "l": "L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine"}, {"i": "EC:2.6.1.66", "l": "\"Valine--pyruvate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19522", "l": "acetyl-CoA + phosphate => acetyl phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610732", "l": "GSK3 phosphorylates p-GLI3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227804", "l": "Inhibition of MDA5-IPS1 signaling by Atg5-Atg12 conjugate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16350", "l": "AH2 + chlorate => A + chlorite + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70577", "l": "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45213", "l": "[Co(I) corrinoid Fe-S protein] + acetyl-CoA + H(+) => [methyl-Co(III) corrinoid Fe-S protein] + CO + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60977", "l": "(E)-4-hydroxynon-2-en-1-ol + NAD(+) => (E)-4-hydroxynon-2-enal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37296", "l": "ATP + H2O + L-alanyl-L-threonine(out) => ADP + H(+) + L-alanyl-L-threonine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139893", "l": "Granzyme-B activates BID by cleavage (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247849", "l": "WLS dissociates from retromer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46286", "l": "(6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O => 2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139893", "l": "Granzyme-B activates BID by cleavage (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70613", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10419", "l": "fumarate + toluene <=> 2-benzylsuccinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52972", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] = a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6783681", "l": "LIF binds LIFR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.149", "l": "\"20-alpha-hydroxysteroid dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41469", "l": "ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oryzalexin E + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682011", "l": "LC3 binds ATG7 dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694580", "l": "nsp8 binds MAP1LC3B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19924", "l": "D-ribitol 5-phosphate + NADP(+) <=> D-ribulose 5-phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080146", "l": "L-cysteine desulfhydrase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11480", "l": "3-hydroxybenzoate + H(+) + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP(+)"}, {"i": "EC:1.14.13.23", "l": "\"3-hydroxybenzoate 4-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106331", "l": "sialate 4-O-acetylesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34104", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18526", "l": "3-methylbutanol + NADP(+) => 3-methylbutanal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937814", "l": "RUNX3 translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869694", "l": "oxPL binds CD14 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015499", "l": "formate transmembrane transporter activity"}, {"i": "RHEA:29679", "l": "formate(in) = formate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013435", "l": "RHOD auto-activates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863463", "l": "STON2 binds SYT proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937177", "l": "AHR:TCDD binds ARNT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54310", "l": "H(+) + N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-homocysteine => pseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17340", "l": "catechol + O2 <=> (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972975", "l": "POU5F1 (OCT4), SOX2, NANOG Bind the SALL1 Promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20679", "l": "1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP => alizarin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64937", "l": "dGTP + H2O => dGDP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46066", "l": "(6Z,11E)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (11E)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944099", "l": "Activated PPARG binds PTEN gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55398", "l": "(3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine => (R)-carnitine + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42746", "l": "H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45016", "l": "5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine = L-selenomethionine + tetrahydropteroyltri-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60660", "l": "1,4-benzoquinone + H(+) + NADH = hydroquinone + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66776", "l": "ATP + H2O + uroporphyrin III(in) = ADP + H(+) + phosphate + uroporphyrin III(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2172678", "l": "PHF8 demethylates histone H4K20me1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63352", "l": "2 H(+) + O2 + octadecanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] = (9Z)-octadecenoyl-CoA + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.156", "l": "\"Oligosaccharide reducing-end xylanase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168893", "l": "Binding of NEP/NS2 to vRNP:M1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3325540", "l": "Defective extracellular BTD does not hydrolyse BCTN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400434", "l": "FFAR1 binds fatty acids (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58835", "l": "24-methylenecycloartanol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13639", "l": "H2O + methanol + NAD(+) => H(+) + methane + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018850", "l": "chloromuconate cycloisomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797810", "l": "PTPRD binds IL1RAPL1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23031", "l": "malonyl-[ACP] + N(6)-biotinyl-L-lysyl-[protein] <=> acetyl-[ACP] + N(6)-carboxybiotinyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938853", "l": "CDK6 binds RUNX1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111264", "l": "Addition of nucleotides between position +11 and +30 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33688", "l": "3'-N-debenzoyltaxol + benzoyl-CoA => CoA + H(+) + taxol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5336443", "l": "LIN7, CASK and APBA1 bind (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20011", "l": "H(+) + linamarin + UDP => 2-hydroxy-2-methylpropanenitrile + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032136", "l": "adenine/cytosine mispair binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34155", "l": "acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine = CoA + H(+) + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose"}, {"i": "EC:2.3.1.202", "l": "\"UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264435", "l": "Dissociation of the COP1-p53 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670619", "l": "Defective ATRX does not bind DAXX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48386", "l": "3-hydroxy fatty acid + H2O => 2,3-saturated fatty acid + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63055", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + methanol"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005415", "l": "nucleoside:sodium symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44617", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + H2O => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40646", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51007", "l": "2 [Fe(III)cytochrome cL] + a primary alcohol <=> 2 [Fe(II)cytochrome cL] + an aldehyde + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54982", "l": "[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n+1)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55246", "l": "4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25544", "l": "ent-copalyl diphosphate = diphosphate + ent-pimara-9(11),15-diene"}, {"i": "EC:4.2.3.31", "l": "\"Ent-pimara-9(11),15-diene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10573", "l": "vinylacetyl-CoA => (2E)-butenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62552", "l": "beta-D-glucosylceramide + UDP-alpha-D-galactose = beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47492", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH = isodeoxycholate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32299", "l": "2 (2E,6E)-farnesyl diphosphate + H(+) + NADH = 2 diphosphate + NAD(+) + squalene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2545196", "l": "FN1 dimerizes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17117", "l": "ATP + L-glutamate + methylamine = ADP + H(+) + N(5)-methyl-L-glutamine + phosphate"}, {"i": "EC:6.3.4.12", "l": "\"Glutamate--methylamine ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004491", "l": "methylmalonate-semialdehyde dehydrogenase (acylating) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2090079", "l": "GLB1 hydrolyses linker chain(2) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60376", "l": "D-glucose(out) = D-glucose(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34900", "l": "malonyl-CoA + S-adenosyl-L-methionine => malonyl-CoA methyl ester + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102382", "l": "rebaudioside B glucosyltransferase activity"}, {"i": "MetaCyc:RXN-13518"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428510", "l": "ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63798", "l": "C-terminal L-alpha-aminoacyl-[tubulin] + L-glutamate => C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68611", "l": "Formation of ORC(1-5) complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66438", "l": "H(+) + NADPH + pent-1-en-3-one => NADP(+) + pentan-3-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15175", "l": "2 H2O + NADP(+) => H(+) + H2O2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008523", "l": "sodium-dependent multivitamin transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0101013", "l": "mechanosensitive voltage-gated sodium channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473584", "l": "Collagen type III degradation by MMP15 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5655193", "l": "KIAA0101 double monoubiquitination (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034900", "l": "3-(N-formyl)-formiminopyruvate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018849", "l": "muconate cycloisomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66756", "l": "ATP + domoate(in) + H2O = ADP + domoate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56650", "l": "3-oxochol-4,6-dien-24-oyl-CoA + H(+) + NADH => 3-oxochol-4-en-24-oyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110068", "l": "glucosylglycerate phosphorylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371518", "l": "SIRT1 binds to HSF1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23235", "l": "4 [Fe(III)cytochrome c] + hydrazine <=> 4 [Fe(II)cytochrome c] + 4 H(+) + N2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62325", "l": "(+)-malbrancheamide B + chloride + FAD + 2 H(+) => (+)-malbrancheamide + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52562", "l": "3-dehydro-D-erythronate => 2-dehydro-D-erythronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40037", "l": "ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate => ATP + L-glutamate + N-acetyl-L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30188", "l": "(S)-dihydroorotate + a quinone => a quinol + orotate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102751", "l": "UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37461", "l": "1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP => 1D-myo-inositol hexakisphosphate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27346", "l": "FMNH2 + O2 => 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22595", "l": "(9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate <=> (10Z,15Z)-12-oxophytodienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25596", "l": "2-oxoglutarate + H(+) + isochorismate <=> 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68603", "l": "ORC5 binds ORC2:ORC3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027600", "l": "Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047748", "l": "cholestanetetraol 26-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47388", "l": "a tetradecanoate ester + H2O = an aliphatic alcohol + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902282", "l": "voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39781", "l": "(17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47157", "l": "7alpha,25-dihydroxycholesterol + NAD(+) => 7alpha,25-dihydroxy-4-cholesten-3-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60115", "l": "(R)-3-(indol-3-yl)lactoyl-CoA <=> (E)-3-(indol-3-yl)acryloyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019979", "l": "interleukin-4 binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990595", "l": "mast cell secretagogue receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28676", "l": "alpha-D-galactose => beta-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52709", "l": "GMP + H2O => D-ribose 5-phosphate + guanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47259", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23125", "l": "2 (2R)-3-phosphoglycerate + 2 H(+) => CO2 + D-ribulose 1,5-bisphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168400", "l": "iE-DAP elicits a NOD1 response (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56233", "l": "[(1->4)-alpha-D-galacturonosyl](n) + H2O => [(1->4)-alpha-D-galacturonosyl](n-2) + alpha-D-galacturonosyl-(1->4)-D-galacturonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.109"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047087", "l": "protopine 6-monooxygenase activity"}, {"i": "RHEA:22644", "l": "O2 + protopine + reduced [NADPH--hemoprotein reductase] = 6-hydroxyprotopine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.98", "l": "\"Protopine 6-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21124", "l": "cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine = 5-methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22749", "l": "4-hydroxy-4-methyl-2-oxoglutarate => 2 pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507868", "l": "Aquaporins passively transport water into cells (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1248694", "l": "Trans-autophosphorylation of ERBB2 homodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46828", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33707", "l": "ATP + L-threonine = ADP + H(+) + O-phospho-L-threonine"}, {"i": "EC:2.7.1.177", "l": "\"L-threonine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57716", "l": "hydrogencarbonate + NH4(+) = carbamate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50472", "l": "anthraniloyl-CoA + H(+) + malonyl-CoA = (2-aminobenzoyl)acetyl-CoA + CO2 + CoA"}, {"i": "EC:2.3.1.262", "l": "\"Anthraniloyl-CoA anthraniloyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205262", "l": "Direct recruitment of PI3K to p-KIT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33153", "l": "(R)-S(6)-acetyldihydrolipoamide + CoA => (R)-dihydrolipoamide + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20851", "l": "H(+) + O2 + phosphate + pyruvate <=> acetyl phosphate + CO2 + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35463", "l": "5alpha-cholest-7-en-3beta-ol + NAD(+) = 5alpha-cholest-7-en-3-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21713", "l": "L-threo-3-phenylserine => benzaldehyde + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43675", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20662", "l": "D-alanyl-D-alanine + H2O => 2 D-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12039", "l": "(S)-3-(imidazol-5-yl)lactate + NAD(+) <=> 3-(imidazol-5-yl)pyruvate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63353", "l": "2 H(+) + O2 + octadecanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] => (9Z)-octadecenoyl-CoA + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38319", "l": "chorismate + H2O = (3R,4R)-3,4-dihydroxy-3,4-dihydrobenzoate + pyruvate"}, {"i": "EC:3.3.2.13", "l": "\"Chorismatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9668904", "l": "Formation of the CTF18 complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62805", "l": "2 7-demethylsiderin + NADPH + O2 => desertorin A + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59797", "l": "dodecanoyl-CoA + L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] => CoA + H(+) + N(6)-dodecanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205118", "l": "TRAF6 polyubiquitinates NRIF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36935", "l": "(11E)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (9Z,11E)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16043", "l": "[(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate => [(1->3)-beta-D-glucosyl](n) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052763", "l": "ulvan lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163617", "l": "G alpha (s) activates adenylate cyclase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5681980", "l": "ATG12 binds ATG7 dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168883", "l": "Haptoglobin:Hemoglobin binds CD163 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106166", "l": "spindle pole body-nuclear membrane anchor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013110", "l": "RHOC binds effectors at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52378", "l": "(+)-sesamin dicatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) => (+)-sesamin monocatechol + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41482", "l": "an episterol ester + CoA => an acyl-CoA + episterol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047139", "l": "glutathione-homocystine transhydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-622420", "l": "NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610723", "l": "GLI proteins bind SUFU (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25850", "l": "(S)-carvone + H(+) + NADH => (1S,5S)-carveol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52380", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68688", "l": "CDC6 association with ORC:origin complexes mediated by MCM8 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690701", "l": "SHP1 binds p-CD22 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31800", "l": "4-amino-5-aminomethyl-2-methylpyrimidine + H2O => 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357472", "l": "PAK1-3 autophosphorylates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58674", "l": "aldehydo-D-glucuronate => D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008412", "l": "4-hydroxybenzoate octaprenyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114544", "l": "p115-RhoGEF activation of RHOA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27635", "l": "5-dehydro-D-gluconate + NADP(+) => 2,5-didehydro-D-gluconate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005250", "l": "A-type (transient outward) potassium channel activity"}, {"i": "REACT:R-HSA-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31474", "l": "beta-D-gentiobiosyl crocetin + UDP-alpha-D-glucose <=> beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389352", "l": "Translocation of Vav1 to CD28 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141437", "l": "Formation of the MCC complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684052", "l": "PIAS4 SUMOylates MDC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432401", "l": "JET binds cytosolic TIM, facilitating its ubiquitination (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61456", "l": "7-chlorotetracycline + H(+) + NADPH + O2 = (1S,10S,10aS)-3-(CONH2)-9-Cl-1-(Me2N)-3,3a,4,10-(HO)4-10-Me-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracen-6-olate + CO + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8963864", "l": "CUBN dissociates from 25(OH)D (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56372", "l": "3,4-dihydroxybenzoate + bromide + 2 H(+) + NADPH + O2 = 3-bromo-4,5-dihydroxybenzoate + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60508", "l": "a guanosine in mRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23602", "l": "2-oxohexanoate + L-glutamate => 2-oxoglutarate + L-2-aminohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950518", "l": "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981657", "l": "IL34 dimer binds PTPRZ1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39658", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2 <=> (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29648", "l": "alpha-maltopentaose + phosphate => alpha-D-glucose 1-phosphate + alpha-maltotetraose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64368", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 A = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.12.-", "l": "\"With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)\""}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0046573", "l": "lactonohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59471", "l": "an S-substituted glutathione + H2O <=> an S-substituted L-cysteinylglycine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55079", "l": "4-methylsulfanyl-2-oxobutanoate + H(+) <=> 3-methylsulfanylpropanal + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000399", "l": "RANBP2 SUMOylates SP100 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033936", "l": "polymannuronate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45935", "l": "2-methylhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(3-methyl-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40981", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + H(+) + hexadecanoate => 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16993", "l": "6 [Fe(III)cytochrome c] + 3 H2O + S-disulfanyl-L-cysteinyl-[SoxY protein] = 6 [Fe(II)cytochrome c] + 7 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]"}, {"i": "EC:1.8.2.6", "l": "\"S-disulfanyl-L-cysteine oxidoreductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193482", "l": "25(R) DHCA-CoA is translocated from the cytosol to the peroxisome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41348", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17276", "l": "(4-hydroxyphenyl)acetaldehyde + H2O + NAD(+) <=> 4-hydroxyphenylacetate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.199", "l": "\"Beta-mannosylphosphodecaprenol--mannooligosaccharide 6-mannosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25903", "l": "D-arabino-hex-3-ulose 6-phosphate <=> beta-D-fructose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24584", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H2O + NAD(+) = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018595", "l": "alpha-pinene monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1227964", "l": "ERBB2 homodimerization (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2769007", "l": "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9698844", "l": "MLKL binds HSP90:CDC37 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.17"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63307", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26434", "l": "indole + L-serine = H2O + L-tryptophan"}, {"i": "EC:4.2.1.122", "l": "\"Tryptophan synthase (indole-salvaging)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696131", "l": "AOC1 deaminates Hist (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247839", "l": "Retromer associates with WLS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416698", "l": "SEMA5A binds to PLXNB3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13818", "l": "[protein]-disulfide + H2O + phylloquinone => 2,3-epoxyphylloquinone + [protein]-dithiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635842", "l": "ULK3 phosphorylates GLI (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.81", "l": "\"(+)-pulegone reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59962", "l": "N(alpha)-acetyl-L-methionine => N(alpha)-acetyl-D-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12247", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + FADH2 <=> (6S)-5,6,7,8-tetrahydrofolate + dTMP + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.23", "l": "\"2-hydroxypropyl-CoM lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9693198", "l": "RHOD binds effectors at the plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36867", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72621", "l": "Ribosomal scanning  (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28331", "l": "H2O + ITP => H(+) + IDP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30157", "l": "FAD + 2 Fe(2+) + 3 H(+) => FADH2 + 2 Fe(3+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3857336", "l": "CEBPB homodimerization (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8950782", "l": "p-STAT1 binds p-STAT3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26374", "l": "[thioredoxin]-disulfide + prostamide F2alpha => [thioredoxin]-dithiol + prostamide H2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11199", "l": "5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide <=> alpha-ribazole 5'-phosphate + H(+) + nicotinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003838", "l": "sterol 24-C-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23551", "l": "guanosine(966) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23458", "l": "A + crepenynate + 2 H2O => (9Z,12Z)-octadecadienoate + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55410", "l": "[phosphate](n+1) + CDP => [phosphate](n) + CTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814374", "l": "Kazrin binds periplakin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419843", "l": "CALCA(83-119) binds CALCR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25759", "l": "ent-copalyl diphosphate = diphosphate + ent-isokaurene"}, {"i": "EC:4.2.3.103", "l": "\"Ent-isokaurene synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030171", "l": "voltage-gated proton channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805285", "l": "PLK3 phosphorylates TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1297354", "l": "Acrosin Cleavage (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64981", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53357", "l": "5,6-dihydrouridine(20b) in tRNA + NADP(+) => H(+) + NADPH + uridine(20b) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37290", "l": "ATP + H2O + L-alanyl-L-leucine(out) <=> ADP + H(+) + L-alanyl-L-leucine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14012", "l": "2 dimethylallyl diphosphate <=> (R,R)-chrysanthemyl diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004399", "l": "histidinol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65285", "l": "alpha-NeuNAc-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1<->1')-L-Thr-[protein] + CMP-N-acetyl-beta-neuraminate => alpha-NeuNAc-(2->3)-beta-D-Gal-(1->3)-[alpha-NeuNAc-(2->6)]-alpha-D-GalNAc-(1<->1')-L-Thr-[protein] + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051978", "l": "lysophospholipid:sodium symporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043404", "l": "corticotropin-releasing hormone receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928645", "l": "EPHB:NMDAR binds TIAM1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29951", "l": "H(+)(in) + uridine(in) = H(+)(out) + uridine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11214", "l": "2-formamidobenzaldehyde => indole + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26275", "l": "Co-precorrin-4 + S-adenosyl-L-homocysteine => Co-precorrin-3 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41874", "l": "(3R)-hydroxydodecanoyl-[ACP] + NADP(+) => 3-oxododecanoyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38190", "l": "19-oxotestosterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta-estradiol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12037", "l": "(S)-3-(imidazol-5-yl)lactate + NAD(+) => 3-(imidazol-5-yl)pyruvate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730848", "l": "Recruitment of GAB2 to PM and FCERI by binding to GRB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167474", "l": "Abortive HIV-1 Initiation Before Second Transition (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49440", "l": "(R)-2-hydroxy-4-methylpentanoate + 4-methylpentanoyl-CoA = (R)-2-hydroxy-4-methylpentanoyl-CoA + 4-methylpentanoate"}, {"i": "EC:2.8.3.24", "l": "\"(R)-2-hydroxy-4-methylpentanoate CoA-transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692779", "l": "p-S182 MAPKAPK5 phosphorylates FOXO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10292", "l": "acetyl-CoA + D-glucosamine 6-phosphate = CoA + H(+) + N-acetyl-D-glucosamine 6-phosphate"}, {"i": "EC:2.3.1.4", "l": "\"Glucosamine-phosphate N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25192", "l": "chloroacetate + H2O <=> chloride + glycolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50523", "l": "acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58420", "l": "NADP(+) + prenol = 3-methyl-2-butenal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2396029", "l": "Latent TGF-beta-3 binds integrins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114254", "l": "CYCS binds to APAF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12173", "l": "alpha-D-glucosamine 6-phosphate + H2O => beta-D-fructose 6-phosphate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8987214", "l": "p-STAT3 dimerizes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.1", "l": "\"Dipeptidyl-peptidase I\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655284", "l": "Activated FGFR4 mutants phosphorylate FRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730863", "l": "Phosphorylation of CARMA1 by PKC-theta (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665748", "l": "FMNL2 binds RHOC:GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34539", "l": "S-adenosyl-L-methionine + tellurite = methanetellurite + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.265", "l": "\"Tellurite methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.28"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8870466", "l": "RGGT:CHM binds RABs (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24125", "l": "all-trans-retinal => 11-cis-retinal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9734730", "l": "ORC1 translocates to the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198513", "l": "Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004361", "l": "glutaryl-CoA dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983307", "l": "IL15 binds IL15RA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64696", "l": "benzyl alcohol + NAD(+) = benzaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.34", "l": "\"Legumain\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.116"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10846", "l": "L-aspartate + pyridoxal => oxaloacetate + pyridoxamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858346", "l": "AMHR2 binds AMH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632653", "l": "Hh-Npp binds BOC:PTCH1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.12"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38480", "l": "N(alpha)-methyl-L-histidine + S-adenosyl-L-methionine => H(+) + N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64890", "l": "AMP + diphosphate + tetradecanoyl-[ACP] => ATP + holo-[ACP] + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42935", "l": "cytidine(32) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.28"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381087", "l": "Dimerization of PERK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448963", "l": "Interaction of MyoD:E protein with MEF2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19089", "l": "S-adenosyl-L-methionine + uroporphyrinogen III = H(+) + precorrin-1 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5655483", "l": "USP1 autocleavage (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25522", "l": "CoA + H(+) + O-acylpseudotropine => an acyl-CoA + pseudotropine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29675", "l": "glycerol(in) = glycerol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47872", "l": "ganglioside GM1 + H2O = ganglioside GA1 + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797553", "l": "Protein 4.1 binds CASK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36707", "l": "O-ureido-L-serine = O-ureido-D-serine"}, {"i": "EC:5.1.1.19", "l": "\"O-ureido-serine racemase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24957", "l": "H2O + N-acetyl-beta-D-muramate 6-phosphate => (R)-lactate + N-acetyl-beta-D-glucosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877941", "l": "RUNX2 binds SMAD1 in the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198714", "l": "ERK5 translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189062", "l": "lactose + H2O => D-glucose + D-galactose (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24608", "l": "5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate + CO2 + H2O"}, {"i": "EC:4.2.1.41", "l": "\"5-dehydro-4-deoxyglucarate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939900", "l": "RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.23"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36673", "l": "CoA + H(+) + N-[(17Z)-hexacosenoyl]dihydrosphingosine => (17Z)-hexacosenoyl-CoA + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41989", "l": "3beta-hydroxy-5alpha-pregnane-20-one + NAD(+) => 5alpha-pregnane-3,20-dione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62093", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-diphosphate + H2O => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65238", "l": "3-methylbutyl acetate + CoA => 3-methylbutanol + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047969", "l": "glyoxylate oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158832", "l": "The acetyl group from acetyl-CoA is transferred to the NAT2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018825", "l": "triethanolamine lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31847", "l": "(S)-2,3-epoxysqualene = shionone"}, {"i": "EC:5.4.99.46", "l": "\"Shionone synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13879", "l": "an L-alpha-amino acid + L-glutamate 5-semialdehyde => a 2-oxocarboxylate + L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1250264", "l": "TXNIP binds reduced thioredoxin (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070538", "l": "oleic acid binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047824", "l": "D-iditol 2-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45703", "l": "glycine betaine + H2O + O2 <=> formaldehyde + H2O2 + N,N-dimethylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13162", "l": "L-threonine + NAD(+) => (2S)-2-amino-3-oxobutanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714483", "l": "RAC2 translocates to the ER membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21206", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester => a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379893", "l": "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391372", "l": "GNRHR binds GNRH1,2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42669", "l": "L-rhamnofuranose + NADP(+) => H(+) + L-rhamnono-1,4-lactone + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41276", "l": "H2O + N-eicosanoyl-sphing-4-enine => eicosanoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050351", "l": "trimetaphosphatase activity"}, {"i": "MetaCyc:TRIMETAPHOSPHATASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709317", "l": "CO binds to free ferrohemoglobin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322431", "l": "XIAP binds TLE (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34814", "l": "NADP(+) + tetrahydrocurcumin <=> dihydrocurcumin + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788623", "l": "p-Y-STATs translocate to nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40130", "l": "an omega-oxo fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> a dicarboxylate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109817", "l": "GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354077", "l": "Integrin alphaIIb beta3 activation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26003", "l": "D-arabinitol 1-phosphate + NAD(+) => D-xylulose 5-phosphate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2314686", "l": "Aspirin acetylates PTGS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-349455", "l": "Phosphorylation of MDM4 by ATM (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0005371", "l": "tricarboxylate secondary active transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9656947", "l": "OGG1beta translocates to mitochondria (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804276", "l": "ATM phosphorylates TTC5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59698", "l": "D-cellotetraonate + H(+) => D-cellotetraono-1,5-lactone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3134954", "l": "DHX9 binds DNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13700", "l": "ATP + D-ribose <=> ADP + D-ribose 5-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-517705", "l": "p-S318,221-HuR binds mRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.112"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42560", "l": "uridine(27/28) in mitochondrial tRNA = pseudouridine(27/28) in mitochondrial tRNA"}, {"i": "EC:5.4.99.44", "l": "\"Mitochondrial tRNA pseudouridine(27/28) synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678981", "l": "TLR9 processing at neutral pH (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018774", "l": "RHOBTB1 binds GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13566", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol => 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034988", "l": "Fc-gamma receptor I complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023159", "l": "Carboxypeptidase E cleaves C-peptide (Insulin(57-89)) to yield C-peptide (Insulin(57-87)) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658435", "l": "RAS GAPs bind RAS:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190829", "l": "Lysosomal degradation of gap junction plaques (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450387", "l": "HuR binds the CRM1 nuclear export machinery (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905108", "l": "guanosine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49898", "l": "5,10-dihydrophenazine-1,6-dicarboxylate => (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080139", "l": "borate efflux transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672978", "l": "RAF phosphorylates MAP2K dimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36427", "l": "2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944220", "l": "Association of procollagen type XXIII (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391372", "l": "GNRHR binds GNRH1,2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14199", "l": "ADP + H(+) + L-asparagine + phosphate => ATP + L-aspartate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797763", "l": "TP53 inhibits BIRC5 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216048", "l": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014296", "l": "RAC2 GEFs activate RAC2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021357", "l": "PRKCI phosphorylates ELF3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11037", "l": "ATP + H2O + quaternary ammonium(out) => ADP + H(+) + phosphate + quaternary ammonium(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109701", "l": "PDPK1 binds PIP3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62048", "l": "an N-aryl-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = an N-aryl-1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12528", "l": "N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate = [hyaluronan](n+1) + H(+) + UDP"}, {"i": "RHEA:20465", "l": "[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP"}, {"i": "EC:2.4.1.212", "l": "\"Hyaluronan synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48106", "l": "H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine => N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682011", "l": "LC3 binds ATG7 dimer (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044589", "l": "pectin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58467", "l": "a neolactoside nLc4Cer + UDP-N-acetyl-alpha-D-glucosamine <=> a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45207", "l": "[Co(I) methanol-specific corrinoid protein] + H(+) + methanol <=> [methyl-Co(III) methanol-specific corrinoid protein] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247569", "l": "PADI4 deiminates Histones (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086090", "l": "voltage-gated potassium channel activity involved in SA node cell action potential repolarization"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5223313", "l": "ABCD4:LMBRD1 transports Cbl from lysosomal lumen to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651789", "l": "LIG1 bound to POLB ligates SSB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3788061", "l": "Fibronectin degradation by ADAM8 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66453", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + NADP(+) => 1-(9Z)-octadecenoylglycerone 3-phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63384", "l": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-2-acetyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39512", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA => (2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213201", "l": "Formation of collagen fibres (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51409", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35296", "l": "adenylyl-molybdopterin + H(+) + tungstate => AMP + H2O + W-molybdopterin cofactor"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46315", "l": "3-oxochol-4-en-22-oyl-CoA + acetyl-CoA <=> 3,22-dioxochol-4-en-24-oyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951977", "l": "Acetylated RUNX3 binds to BRD2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57921", "l": "4-phosphooxy-L-aspartyl-tRNA(Asn) + NH4(+) => H(+) + L-asparaginyl-tRNA(Asn) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29690", "l": "alpha-maltoheptaose + phosphate <=> alpha-D-glucose 1-phosphate + alpha-maltohexaose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26234", "l": "(2E,6E,10E)-geranylgeraniol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + plaunotol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033737", "l": "1-pyrroline dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21618", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58323", "l": "25-substituted-cholesterol + a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine <=> 25-substituted-cholesteryl beta-D-glucoside + an N-acylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39889", "l": "H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pikromycin => 2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45266", "l": "(9Z,12Z)-octadecadienoate(in) => (9Z,12Z)-octadecadienoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322422", "l": "Beta-catenin recruits SMARCA4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22373", "l": "H2O + O2 + propionate 3-nitronate => 3-oxopropanoate + H(+) + H2O2 + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855187", "l": "IP6 transports from the nucleus to the ER lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140643", "l": "hydroxymethylglutaryl-CoA reductase (NADH) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56321", "l": "a 5-hydroxy anthocyanidin + UDP-alpha-D-glucose => an anthocyanin 5-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66054", "l": "H2O + kynurenate + L-tryptophan => indole-3-pyruvate + L-kynurenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53360", "l": "5,6-dihydrouridine(47) in tRNA + NADP(+) = H(+) + NADPH + uridine(47) in tRNA"}, {"i": "RHEA:53364", "l": "5,6-dihydrouridine(47) in tRNA + NAD(+) = H(+) + NADH + uridine(47) in tRNA"}, {"i": "EC:1.3.1.89", "l": "\"tRNA-dihydrouridine(47) synthase (NAD(P)(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17197", "l": "2 3-(4-hydroxyphenyl)pyruvate + O2 = 2 4-hydroxyphenylacetate + 2 CO2"}, {"i": "EC:1.2.3.13", "l": "\"4-hydroxyphenylpyruvate oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850534", "l": "PDCL promotes G-protein beta 5 folding (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48532", "l": "ganglioside GQ1c (d18:1(4E)) + H2O = ganglioside GT1c (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604752", "l": "Initial activation of proMMP13 by MMP3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22786", "l": "H(+) + phosphoenolpyruvate + sulfite => (2R)-O-phospho-3-sulfolactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17127", "l": "2-oxoglutarate + N-(2-aminobutanoyl)glycine => H2O + N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62512", "l": "2-oxoglutarate + melatonin + O2 = 2-hydroxymelatonin + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12156", "l": "2-glutathionyl-2-methylbut-3-en-1-ol + H2O + 2 NAD(+) = 2-glutathionyl-2-methylbut-3-enoate + 3 H(+) + 2 NADH"}, {"i": "EC:1.1.1.398", "l": "\"2-glutathionyl-2-methylbut-3-en-1-ol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661230", "l": "MT1A binds arsenic (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42613", "l": "a plastoquinone + (n+1) H(+)(in) + NADPH => a plastoquinol + n H(+)(out) + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47055", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-selinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62292", "l": "(S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) = 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030413", "l": "competence pheromone activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68826", "l": "Free CDT1 associates with CDC6:ORC:origin complexes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21042", "l": "CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25620", "l": "terpentedienyl diphosphate <=> diphosphate + terpentetriene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020504", "l": "MECP2 binds GRIN2B gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018804", "l": "RAC3 GEFs activate RAC3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205118", "l": "TRAF6 polyubiquitinates NRIF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130706", "l": "MHC class II antigen processing (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603598", "l": "BAX activation is stimulated by NTRK3(495-641) and NELFB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15587", "l": "4 AH2 + all-trans-lycopene => 15-cis-phytoene + 4 A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41141", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-448958", "l": "Nuclear translocation of p38 MAPK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20349", "l": "H(+) + NADH + O2 + toluene = 2-hydroxytoluene + H2O + NAD(+)"}, {"i": "RHEA:57948", "l": "2-hydroxytoluene + H(+) + NADH + O2 = 3-methylcatechol + H2O + NAD(+)"}, {"i": "EC:1.14.13.243", "l": "\"Toluene 2-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50250", "l": "ADP-D-ribose + diphosphate => ATP + D-ribose 5-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56860", "l": "a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate = a 2-oxo-3-(phosphooxy)propyl medium-chain 3-oxoalkanoate + holo-[ACP]"}, {"i": "EC:2.3.1.277", "l": "\"2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110215", "l": "Cleavage of uracil by UNG glycosylase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38045", "l": "(4Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035755", "l": "cardiolipin hydrolase activity"}, {"i": "REACT:R-HSA-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13002", "l": "1D-myo-inositol hexakisphosphate + H2O => 1L-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48775", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a <=> 3-deacetyl-3-vinylbacteriochlorophyllide a + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42514", "l": "5-aminopentanoate + acetate => 5-acetamidopentanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070553", "l": "nicotinic acid receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15316", "l": "ethanolamine <=> acetaldehyde + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35590", "l": "FMN + H2O <=> phosphate + riboflavin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57362", "l": "(6R)-NADHX => H2O + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23441", "l": "4-chlorobenzoate + H2O => 4-hydroxybenzoate + chloride + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40286", "l": "(R)-carnitine + hexadecanedioyl-CoA <=> CoA + O-hexadecanedioyl-L-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149519", "l": "MMACHC decyanates CNCbl (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042011", "l": "interleukin-16 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47731", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP-alpha-D-mannose <=> (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-167427", "l": "Opioid dissociates from MOR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042657", "l": "MHC class II protein binding, via lateral surface"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47439", "l": "(2E,7Z)-hexadecadienoyl-CoA + H2O <=> (3S)-hydroxy-(7Z-hexadecenoyl)-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37078", "l": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine <=> 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15489", "l": "adenosine + H2O + 2 O2 = 9-riburonosyladenine + H(+) + 2 H2O2"}, {"i": "EC:1.1.3.39", "l": "\"Nucleoside oxidase (H(2)O(2)-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33095", "l": "chorismate + inosine + phosphoenolpyruvate = futalosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158849", "l": "Phenol can form a sulfate conjugate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20761", "l": "AH2 + linalool + O2 => (6E)-8-hydroxylinalool + A + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "78.423603998002051", "identifiers": [{"i": "GO:0016712", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10998", "l": "2-methylpropanal O-methyloxime + H(+) + S-adenosyl-L-homocysteine => 2-methylpropanal oxime + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60953", "l": "(E)-5-hydroxyferulate + S-adenosyl-L-methionine => E-sinapate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26303", "l": "(S)-allantoin + CO2 => 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050134", "l": "N6-methyl-lysine oxidase activity"}, {"i": "RHEA:23200", "l": "H2O + N(6)-methyl-L-lysine + O2 = formaldehyde + H2O2 + L-lysine"}, {"i": "EC:1.5.3.4", "l": "\"N(6)-methyl-lysine oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36353", "l": "3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + A + H(+) + L-methionine => AH2 + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50253", "l": "an acyl-CoA + H(+) + malonyl-CoA => a 3-oxoacyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48417", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)) => CMP + ganglioside GM2 (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.5.2", "l": "\"Dihydroorotate dehydrogenase (quinone)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139909", "l": "Translocation of BMF to mitochondria (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13547", "l": "(3E,7E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6E,10E)-geranyllinalool + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624953", "l": "ARL13B binds INPP5E (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033678", "l": "5'-3' DNA/RNA helicase activity"}, {"i": "REACT:R-HSA-163120", "l": "Disassociation of Telomerase RNP and the Chromosome End (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191656", "l": "Closure of gap junction (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71849", "l": "LDH tetramer reduces PYR to LACT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875374", "l": "MET binds LRIG1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35048", "l": "adenylyl-molybdopterin + H(+) + molybdate => AMP + H2O + Mo-molybdopterin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44753", "l": "2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48611", "l": "A + a 2,3-saturated acyl-CoA <=> a 2,3-dehydroacyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668714", "l": "RAC1:GTP binds NOX1 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2172678", "l": "PHF8 demethylates histone H4K20me1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938356", "l": "RMB14 binds RUNX2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374919", "l": "Noradrenaline clearance from the synaptic cleft (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17916", "l": "H2O + NAD(+) + nitrite <=> H(+) + NADH + nitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2197691", "l": "WIP binds WASP,N-WASP, activating them (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20946", "l": "caffeine + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + theobromine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159773", "l": "Furin cleaves pro-protein S to protein S (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-171059", "l": "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23147", "l": "H2O + N-acetyl-alpha-D-glucosamine + NAD(+) <=> 2 H(+) + N-acetyl-D-glucosaminate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805276", "l": "CDK5 phosphorylates TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008766", "l": "UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40935", "l": "a 1-acylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210290", "l": "Interaction of PECAM-1 and SHIP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2426566", "l": "Interaction of DAP12 and CLM7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33279", "l": "L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.156", "l": "\"Tryptophan N-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.316", "l": "\"Mitomycin 6-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418868", "l": "Recruitment of Src and Fyn to DCC:FADK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42779", "l": "adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40095", "l": "26-oxohexacosanoate + H2O + NAD(+) = 2 H(+) + hexacosanedioate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37535", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65287", "l": "alpha-NeuNAc-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1<->1')-L-Thr-[protein] + CMP-N-acetyl-beta-neuraminate <=> alpha-NeuNAc-(2->3)-beta-D-Gal-(1->3)-[alpha-NeuNAc-(2->6)]-alpha-D-GalNAc-(1<->1')-L-Thr-[protein] + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65331", "l": "A + chrodrimanin F <=> AH2 + chrodrimanin H"}]}
{"type": "biolink:MolecularActivity", "ic": "71.632434359930443", "identifiers": [{"i": "GO:0004536", "l": "deoxyribonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41406", "l": "2-methyl-1-pyrroline + H(+) + NADPH => (R)-2-methylpyrrolidine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.18", "l": "\"Cytosol nonspecific dipeptidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047591", "l": "5-hydroxypentanoate CoA-transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9649733", "l": "mature p21 RAS binds GDP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30654", "l": "2 H2O + O2 + urate <=> allantoin + CO2 + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29133", "l": "H2O + menaquinone-8 + nitrite => menaquinol-8 + nitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61493", "l": "a sphingoid base + an ultra-long-chain fatty acyl-CoA => an N-(ultra-long-chain-acyl)-sphingoid base + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045514", "l": "interleukin-16 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50179", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 <=> N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma-aminobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36831", "l": "2 caldariellaquinol + n H(+)(in) + O2 = 2 caldariellaquinone + n H(+)(out) + 2 H2O"}, {"i": "EC:7.1.1.4", "l": "\"Caldariellaquinol oxidase (H(+)-transporting)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050326", "l": "taxifolin 8-monooxygenase activity"}, {"i": "MetaCyc:TAXIFOLIN-8-MONOOXYGENASE-RXN"}, {"i": "EC:1.14.13.19", "l": "\"Taxifolin 8-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693148", "l": "BCKDK phosphorylates BCKDH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52592", "l": "deoxycholoyl-CoA + NAD(+) = 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2214330", "l": "Cleavage of collagen VII NC2 region by BMP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051062", "l": "UDP reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35593", "l": "H(+) + hydrogen sulfide + (n-1) sulfur => H2 + n sulfur"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.6", "l": "\"Galactonate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53321", "l": "alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose => alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39288", "l": "[Co(I) trimethylamine-specific corrinoid protein] + H(+) + trimethylamine => [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683925", "l": "ULK1 is dephosphorylated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22895", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) <=> 5,10-methenyltetrahydrofolate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110235", "l": "OGG1 glycosylase mediated recognition and binding of an 8-oxoguanine opposite to a cytosine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218805", "l": "PKC autophosphorylates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31767", "l": "2-oxoglutarate + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine = L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose"}, {"i": "EC:2.6.1.92", "l": "\"UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52206", "l": "butyl formate + H2O + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin] => butachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53833", "l": "2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 => a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22305", "l": "A + D-fructose => 5-dehydro-D-fructose + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.34", "l": "\"6,7-dihydropteridine reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1449687", "l": "Corticosteroids bind to CBG in blood (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956684", "l": "ITCH polyubiquitinates TP73 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6795290", "l": "TORC2 complex phosphorylates SGK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0031420", "l": "alkali metal ion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65543", "l": "ganglioside GM3 + H2O <=> an N-acyl-sphingoid base + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443783", "l": "Interaction of NUMB with L1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14648", "l": "H2O + S-adenosyl-L-methionine <=> H(+) + L-homoserine + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25649", "l": "(2R,5R)-isopulegone + NADP(+) = (6R)-isopiperitenone + H(+) + NADPH"}, {"i": "EC:1.3.1.82", "l": "\"(-)-isopiperitenone reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50391", "l": "5a,11a-dehydrotetracycline + H(+) + NADPH + O2 <=> 5a,11a-dehydrooxytetracycline + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168166", "l": "NFkB complex is transported from cytosol to nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019809", "l": "spermidine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33824", "l": "3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvate + H(+) + NADH => NAD(+) + tetrahydro-4-hydroxyphenylpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12850", "l": "H2O + O-phospho-L-seryl-[myosin light chain] => L-seryl-[myosin light chain] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985123", "l": "RNASEL binds 2'-5' oligoadenylate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001228", "l": "DNA-binding transcription activator activity, RNA polymerase II-specific"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10496", "l": "L-arginyl-[myelin basic protein] + S-adenosyl-L-methionine = H(+) + N(omega)-methyl-L-arginyl-[myelin basic protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045303", "l": "diaminobutyrate-2-oxoglutarate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42333", "l": "ATP + L-glutamate + oxidized coenzyme F420-2 => ADP + H(+) + oxidized coenzyme alpha-F420-3 + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13929", "l": "agmatine + H2O = putrescine + urea"}, {"i": "EC:3.5.3.11", "l": "\"Agmatinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37876", "l": "aklanonate + S-adenosyl-L-methionine => methyl aklanonate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30792", "l": "dGTP + pyruvate => dGDP + H(+) + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5625416", "l": "Anterograde IFT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36376", "l": "ATP + carbamoyl phosphate + H2O => carbamoyl adenylate + diphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622831", "l": "Substrate:LAMP2a binds HSP90 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14726", "l": "2 ATP + 2 cob(II)inamide + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)inamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37896", "l": "H2O + protodioscin => 26-deglucoprotodioscin + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875523", "l": "MET binds TNS3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.29"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004528", "l": "phosphodiesterase I activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54832", "l": "a jasmonyl-L-amino acid + O2 + reduced [NADPH--hemoprotein reductase] = a 12-hydroxyjasmonyl-L-alpha-amino acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.48", "l": "\"Jasmonoyl-L-amino acid 12-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004098", "l": "cerebroside-sulfatase activity"}, {"i": "RHEA:21300", "l": "H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate"}, {"i": "EC:3.1.6.8", "l": "\"Cerebroside-sulfatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707659", "l": "Hemes:LY96 activates TLR4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399711", "l": "Activation of Ca impermeable AMPA receptors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5099899", "l": "WNT5A binds FZD4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005112", "l": "Notch binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62035", "l": "a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O <=> a 2-acyl-sn-glycero-3-phosphoglycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695853", "l": "FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20036", "l": "isopenicillin N <=> penicillin N"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58773", "l": "1-O-hexadecyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-O-hexadecyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674018", "l": "BRAP binds RAS:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42212", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O = a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070335", "l": "aspartate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211734", "l": "Ubiquitination of PAK-2p34 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247569", "l": "PADI4 deiminates Histones (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-437139", "l": "ZnT6 transports zinc into the golgi apparatus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53494", "l": "5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out) => 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9028730", "l": "Activated NTRK2 binds FRS2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168140", "l": "Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53310", "l": "16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709547", "l": "ESTG binds ESR2:chaperone complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37041", "l": "5 A + delta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O => 5 AH2 + 2 H(+) + heme b + 4 O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102216", "l": "maltodextrin water dikinase"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004159", "l": "dihydropyrimidine dehydrogenase (NAD+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450802", "l": "FZ and VANG bind to STAN homodimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166219", "l": "FA anion picks up a proton (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784189", "l": "JAKs bind LIFR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12542", "l": "AMP + diphosphate + L-alanyl-tRNA(Ala) => ATP + L-alanine + tRNA(Ala)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109700", "l": "AKT2 binds PIP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57351", "l": "3-hydroxy-4-methyl-L-kynurenine + H2O <=> 3-hydroxy-4-methylanthranilate + H(+) + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72124", "l": "Formation of the Spliceosomal A Complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14121", "l": "3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.12"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16076", "l": "2,2-dialkylglycine + H(+) + pyruvate <=> CO2 + dialkyl ketone + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139918", "l": "Phosphorylation of BIM by JNK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507875", "l": "Aquaporins passively transport urea into cells (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52151", "l": "an (E)-omega-(methylsulfanyl)alkyl-thiohydroximate + UDP-alpha-D-glucose <=> an aliphatic desulfo-glucosinolate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14015", "l": "adenosine 3',5'-bisphosphate + H(+) + taurolithocholate 3-sulfate => 3'-phosphoadenylyl sulfate + taurolithocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18231", "l": "glyoxylate + H(+) + NADH => glycolate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21270", "l": "berberine + H(+) + 2 NADPH => (R)-canadine + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948136", "l": "ULK1 Translocates to the mitochondria (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44236", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52936", "l": "3-oxobutanoyl-[ACP] + acetyl-[ACP] + H2O = (3S)-hydroxy-3-methylglutaryl-[ACP] + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10060", "l": "acetyl-CoA + D-tryptophan = CoA + H(+) + N-acetyl-D-tryptophan"}, {"i": "EC:2.3.1.34", "l": "\"D-tryptophan N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0004748", "l": "ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"}, {"i": "REACT:R-HSA-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983424", "l": "Budding of COPII coated vesicle (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49937", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49144", "l": "2-oxoglutarate + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate"}, {"i": "EC:2.6.1.110", "l": "\"dTDP-4-dehydro-2,3,6-trideoxy-D-glucose 4-aminotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35909", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA => 1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380311", "l": "Recruitment of Plk1 to centrosomes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16390", "l": "4-hydroxybenzoate + 2 H(+) + NADH + O2 => CO2 + H2O + hydroquinone + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62969", "l": "(R)-lactate + NADP(+) => H(+) + NADPH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047020", "l": "15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31148", "l": "3,4-dihydroxyphenylethyleneglycol + NAD(+) => 3,4-dihydroxymandelaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381109", "l": "IRE1 binds IRE1 forming dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696958", "l": "USP44 deubiquitinates CDC20 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42051", "l": "3-hydroxybutanoyl-CoA + NAD(+) <=> acetoacetyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863727", "l": "STON2 is neddylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429683", "l": "CERT:ceramide [ER] => ceramide [Golgi] + CERT [ER] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62058", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+) => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47097", "l": "(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate => (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102799", "l": "glucosinolate glucohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15649", "l": "carbamate + 2 H(+) = CO2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32737", "l": "1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5333678", "l": "CPNEs bind PL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50736", "l": "a quinone + 2 H(+) + hydrogen sulfide + sulfite = a quinol + thiosulfate"}, {"i": "EC:1.8.5.5", "l": "\"Thiosulfate reductase (quinone)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-350598", "l": "Arginine<=>Agmatine+CO2 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177926", "l": "Dephosphorylation of PAG by SHP2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22105", "l": "2-oxoglutarate + nicotianamine => 3''-deamino-3''-oxonicotianamine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30221", "l": "dimethyl sulfone + H(+) + NADH => dimethyl sulfoxide + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50638", "l": "a 2-(omega-methylsulfanyl)alkylmaleate + H2O => a 3-(omega-methylsulfanyl)alkylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443783", "l": "Interaction of NUMB with L1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37244", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33608", "l": "(9Z)-octadecenoate + ATP + CoA => (9Z)-octadecenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62835", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc]oxy}nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865275", "l": "PDGF-BB clevage by Furin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2317332", "l": "PIP3 recruits AKT to the membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31845", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA => 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16201", "l": "4-amino-4-deoxychorismate = 4-aminobenzoate + H(+) + pyruvate"}, {"i": "EC:4.1.3.38", "l": "\"Aminodeoxychorismate lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218821", "l": "PDK1 phosphorylates PKC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34574", "l": "C30 botryococcene + diphosphate + NADP(+) <=> H(+) + NADPH + presqualene diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32761", "l": "(3R)-3-methyl-D-ornithine => L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51863", "l": "(2E)-geranyl diphosphate + umbelliferone <=> 8-geranylumbelliferone + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17871", "l": "6,7-dihydropteridine + H(+) + NADH => 5,6,7,8-tetrahydropteridine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64258", "l": "CoA + H(+) + N-dodecanoylglycine => dodecanoyl-CoA + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14812", "l": "phenol + S-adenosyl-L-methionine <=> anisole + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23127", "l": "2 (2R)-3-phosphoglycerate + 2 H(+) <=> CO2 + D-ribulose 1,5-bisphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41220", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-874087", "l": "SGT1 binds HSP90 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2250301", "l": "Formation of lysyl-pyrrole cross-links (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66882", "l": "10-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45915", "l": "a (2E,4E)-dienoyl-CoA + H(+) + NADPH <=> a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36912", "l": "(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044104", "l": "2,5-dioxovalerate dehydrogenase (NAD+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2059926", "l": "NPHP4 protein binds LATS proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0051427", "l": "hormone receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71303", "l": "RPE dimers isomerise RU5P to XY5P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31316", "l": "(2R)-3-phosphoglycerate + GDP-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53990", "l": "L-threonyl-[myosin light chain] + phosphate => H2O + O-phospho-L-threonyl-[myosin light chain]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63094", "l": "H2O + ilicicolin A epoxide + NADP(+) => H(+) + ilicicolin A + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58359", "l": "2-oxoglutarate + N(omega)-methyl-L-arginyl-[protein] + O2 <=> CO2 + formaldehyde + L-arginyl-[protein] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418850", "l": "Activation of Cdc42 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13052", "l": "D-glucuronate <=> D-fructuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182243", "l": "Formation of MHC I:Nef Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.54", "l": "\"Lytic cellulose monooxygenase (C1-hydroxylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198813", "l": "GSTO dimers reduce DeHA to AscH- (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854981", "l": "SHC1 in the RET complex is phosphorylated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53919", "l": "an acyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-acyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60841", "l": "a 5'-end diphospho-adenosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] => a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11516", "l": "H2O + succinyl-CoA = CoA + H(+) + succinate"}, {"i": "EC:3.1.2.3", "l": "\"Succinyl-CoA hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3791319", "l": "NID1 degradation by MMP19 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12743", "l": "IDP + NH4(+) => ADP + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28268", "l": "(S)-beta-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63824", "l": "2 3-(4-hydroxyphenyl)pyruvate = aspulvinone E + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010242", "l": "oxygen evolving activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1370505", "l": "PRLR is phosphorylated at Ser-349 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24959", "l": "H2O + N-acetyl-beta-D-muramate 6-phosphate <=> (R)-lactate + N-acetyl-beta-D-glucosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173680", "l": "Activation of C5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52968", "l": "hyocholate + UDP-alpha-D-glucuronate = H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37894", "l": "aclacinomycin T + H2O <=> 15-demethylaclacinomycin T + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29083", "l": "(S)-malate + ubiquinone-8 = oxaloacetate + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58946", "l": "7 CO2 + 8 CoA + demethyldeoxyspectinabilin + 5 H2O + 6 NADP(+) => 6 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 12 H(+) + malonyl-CoA + 6 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39061", "l": "26-oxohexacosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 26-hydroxyhexacosanoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21553", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005055", "l": "laminin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9681616", "l": "AP2 binds chlorpromazine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047790", "l": "creatinine deaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682026", "l": "MRN bound to shortened telomeres activates ATM (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983147", "l": "Release of E3 from polyubiquitinated substrate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37311", "l": "ATP + glycyl-L-glutamine(out) + H2O = ADP + glycyl-L-glutamine(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036221", "l": "UTP diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5661230", "l": "MT1A binds arsenic (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41292", "l": "H2O + N-dodecanoylsphing-4-enine => dodecanoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657791", "l": "miR-144 binds to the 3'UTR of the ABCA1 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34935", "l": "2 ATP + H(+) = diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218832", "l": "CDC42:GTP binds PAK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49443", "l": "(R)-2-hydroxy-4-methylpentanoate + 4-methylpentanoyl-CoA <=> (R)-2-hydroxy-4-methylpentanoyl-CoA + 4-methylpentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801109", "l": "CHM binds RGGT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39522", "l": "3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25785", "l": "2-dehydro-3-deoxy-L-rhamnonate => (S)-lactaldehyde + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22391", "l": "acetyl-CoA + N(6)-hydroxy-L-lysine <=> CoA + N(6)-acetyl-N(6)-hydroxy-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55835", "l": "cortisone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxycortisone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56761", "l": "24,25-dihydrolanosterol + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54618", "l": "2-hydroxyheptadecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + heptadecanoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694441", "l": "3CLp cleaves pp1a (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985594", "l": "MYO9B inactivates RHOA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5444516", "l": "Formation of MSH2:MSH6 Complex (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59622", "l": "4-aminobutanoate + L-lysine => H2O + N(2)-(4-aminobutanoyl)-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64964", "l": "dUTP + 2 H2O = dUMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10151", "l": "blasticidin S + H(+) + H2O <=> deaminohydroxyblasticidin S + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983138", "l": "Transport of MHC heterotrimer to ER exit site (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41329", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => (12S)-hydroperoxy-(8Z,10E,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55500", "l": "ent-cassa-12,15-dien-2beta,3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430347", "l": "MigFilin associates with Filamin and F-actin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38458", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863494", "l": "ASICs bind STOML3, (STOM) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39824", "l": "2 [Fe(II)-cytochrome b5] + eicosanoate + 2 H(+) + O2 => 2-hydroxyeicosanoate + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29055", "l": "a ubiquinone + 2 H(+)(in) + H2 = a ubiquinol + 2 H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606288", "l": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51906", "l": "10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate => 10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22322", "l": "D-maltose + 2 phosphate => 2 alpha-D-glucose 1-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205075", "l": "JNK phosphorylates BIM, BAD and other targets (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44966", "l": "dodecanoyl-CoA + NADP(+) => (2E)-dodecenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31189", "l": "3-oxodecanoyl-CoA + H(+) + NADH => (3S)-hydroxydecanoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55518", "l": "11-oxocucurbitadienol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 11-hydroxycucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36378", "l": "ATP + carbamoyl phosphate + H2O <=> carbamoyl adenylate + diphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004918", "l": "interleukin-8 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40919", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58035", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52731", "l": "3'-phosphoadenylyl sulfate + a 12-hydroxyjasmonate <=> a 12-sulfojasmonate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32420", "l": "(1S,2R,4R)-neoisodihydrocarveol + NAD(+) => (1S,4R)-isodihydrocarvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60715", "l": "(+)-artemisinic alcohol + NAD(+) <=> (+)-artemisinic aldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60346", "l": "H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine => L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210430", "l": "Release of L-Glutamate at the synapse (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102375", "l": "11-oxo-beta-amyrin 30-oxidase activity"}, {"i": "RHEA:35499", "l": "11-oxo-beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = glycyrrhetinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.115", "l": "\"11-oxo-beta-amyrin 30-oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686790", "l": "ER-alpha glucosidases bind ER-alpha glucosidase inhibitors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33220", "l": "ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => gibberellin A12 + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985157", "l": "OAS3 binds viral dsRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803999", "l": "HNO2 produces N2O3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "79.238648346243679", "identifiers": [{"i": "GO:0016880", "l": "acid-ammonia (or amide) ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25064", "l": "3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH => 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008403", "l": "25-hydroxycholecalciferol-24-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672978", "l": "RAF phosphorylates MAP2K dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102732", "l": "myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity"}, {"i": "MetaCyc:RXN-7186"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61609", "l": "[DsbB protein]-dithiol + a quinone => [DsbB protein]-disulfide + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026890", "l": "NTRK2 phosphorylates SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159795", "l": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36200", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-sn-glycerol + H(+) + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34083", "l": "a (3R)-3-hydroxyacyl-CoA = a (3S)-3-hydroxyacyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55563", "l": "a hydroperoxyeicosatetraenoate <=> a hydroxy-epoxy-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433454", "l": "Phosphorylation of GAB2 by SFKs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53900", "l": "ATP + L-threonyl-[myosin light chain] = ADP + H(+) + O-phospho-L-threonyl-[myosin light chain]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36455", "l": "ATP + H2O + L-alanylglycine(out) = ADP + H(+) + L-alanylglycine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909726", "l": "Phosphorylation of STAT1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54893", "l": "[LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide => [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33433", "l": "(3E)-2-oxohex-3-enedioate => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421836", "l": "trans-Golgi Network Derived Vesicle Uncoating (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10726", "l": "GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH => GDP-6-deoxy-alpha-D-talose + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351913", "l": "Caspase-mediated cleavage of TJP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013109", "l": "RHOC GEFs activate RHOC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13780", "l": "ATP + D-ribose 5-phosphate + NH4(+) <=> 5-phospho-beta-D-ribosylamine + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55707", "l": "glycine + hydrogen sulfide + NAD(+) <=> ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192123", "l": "CYP27A1 27-hydroxylates CHOL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62353", "l": "H(+) + NADPH + notoamide E + O2 => H2O + NADP(+) + notoamide D"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714481", "l": "RAC2 binds effectors at the ER membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683801", "l": "CHEK2 phosphorylates BRCA1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626549", "l": "IQGAPs bind CALM1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40251", "l": "4-O-methylrhodomycin D + H2O = 10-carboxy-13-deoxydaunorubicin + H(+) + methanol"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0048306", "l": "calcium-dependent protein binding"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0140597", "l": "protein carrier activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76373", "l": "N-hydroxylation of 4-aminobiphenyl (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32557", "l": "(R)-alpha-terpineol + diphosphate => (2E)-geranyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912359", "l": "HES1 binds TLE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74740", "l": "Binding of SHC1 to insulin receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400256", "l": "CRY:PER heterodimer binds the BMAL1:CLOCK/NPAS2 heterodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58523", "l": "(19S)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] <=> akuammicine + formate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5213466", "l": "RIPK3 is phosphorylated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65222", "l": "catechol + H(+) + NADPH => (1S,2S)-1,2-dihydrobenzene-1,2-diol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871376", "l": "p-Y281,292-RUFY1 binds PI3P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635842", "l": "ULK3 phosphorylates GLI (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56588", "l": "a monosubstituted aliphatic (S)-hydroxynitrile = an aldehyde + hydrogen cyanide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351604", "l": "Noradrenaline translocates to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103097", "l": "CYP79F1 trihomomethionine monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44790", "l": "H(+) + menaquinol-11 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-11 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30178", "l": "15-cis-phytoene + 2 plastoquinone-9 <=> 9,9',15-tri-cis-zeta-carotene + 2 plastoquinol-9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14492", "l": "a nucleoside 2',3'-cyclic phosphate + H2O <=> a nucleoside 2'-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30560", "l": "GTP + H2O => guanosine + H(+) + triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42863", "l": "1,2-dioctanoyl-sn-glycero-3-phosphate + H2O <=> 1,2-dioctanoyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047636", "l": "alanopine dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085083", "l": "Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50833", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 => 17-hydroperoxy-(7Z,10Z,13Z,15E,19Z)-docosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58730", "l": "H(+) + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine => adenosine in rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1006143", "l": "CD46 binds C3b (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140293", "l": "ADP-ribosylglutamate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008190", "l": "eukaryotic initiation factor 4E binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635861", "l": "NUMB:ITCH binds GLI1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683792", "l": "p-T68-CHEK2 autophosphorylates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62972", "l": "acetyl-CoA + 2 H(+) + 3 malonyl-CoA = 3 CO2 + 4 CoA + orsellinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64805", "l": "acetyl-CoA + S-(2-aminoethyl)-L-cysteine => CoA + H(+) + S-(2-acetamidoethyl)-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62792", "l": "3 H(+) + NADPH + O2 + 2 rubrofusarin B = 2 H2O + NADP(+) + nigerone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61951", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl-[protein] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43022", "l": "2-aminoprop-2-enoate + L-homocysteine => L,L-cystathionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36114", "l": "gibberellin A1 + S-adenosyl-L-methionine <=> O-methyl gibberellin A1 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33182", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O <=> 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23993", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59722", "l": "D-maltohexaonate + H(+) => D-maltohexaono-1,5-lactone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437139", "l": "ZnT6 transports zinc into the golgi apparatus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110322", "l": "Formation of Pol zeta complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36739", "l": "heptadecasphing-4-enine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-heptadecasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10057", "l": "(3S)-3-aminobutanoyl-CoA => (2E)-butenoyl-CoA + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432688", "l": "trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42064", "l": "ATP + GTP = 2',3'-cGAMP + 2 diphosphate"}, {"i": "EC:2.7.7.86", "l": "\"Cyclic GMP-AMP synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-398185", "l": "LARG binds plexin B1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004108", "l": "citrate (Si)-synthase activity"}, {"i": "MetaCyc:CITSYN-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24636", "l": "H2 + NAD(+) = H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53677", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 => 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.55", "l": "\"Caldesmon-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28288", "l": "a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.85", "l": "\"S2P endopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30125", "l": "H(+) + holo-[ACP] + tetradecanoate => H2O + tetradecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193641", "l": "IKK-beta is recruited (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39498", "l": "3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008808", "l": "cardiolipin synthase activity"}, {"i": "RHEA:31451", "l": "2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol"}, {"i": "MetaCyc:CARDIOLIPSYN-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-376851", "l": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033951", "l": "oligosaccharide reducing-end xylanase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177479", "l": "Axonal transport of NGF:Trk complexes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51578", "l": "H(+) + phlorizin + UDP => phloretin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788571", "l": "STAT1,STAT3,STAT6 bind IL13:IL13R type II (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034925", "l": "pyrene 4,5-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31864", "l": "(S)-2,3-epoxysqualene => friedelin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072551", "l": "diferuloyl mono-(hydroxyferuloyl) spermidine meta-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37601", "l": "(9Z,12Z,15Z)-hexadecatrienoyl-CoA + A + 2 H2O => (9Z,12Z)-hexadecadienoyl-CoA + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12199", "l": "keto-D-fructose 6-phosphate + phosphate <=> acetyl phosphate + D-erythrose 4-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23098", "l": "4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+) => 4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432946", "l": "PARVB/Affixin interacts with alpha PIX (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24385", "l": "ATP + deamido-NAD(+) + H2O + L-glutamine => AMP + diphosphate + H(+) + L-glutamate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102756", "l": "very-long-chain 3-ketoacyl-CoA synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38697", "l": "a cardiolipin(out) => a cardiolipin(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350168", "l": "LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24757", "l": "H(+) + NADPH + O2 + pheophorbide a => NADP(+) + red chlorophyll catabolite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686318", "l": "GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013023", "l": "RHOB GEFs activate RHOB (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685242", "l": "CHEK1 phosphorylates BRCA2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106266", "l": "3-chloro THPH synthase activity"}, {"i": "RHEA:64356", "l": "2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 = (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37971", "l": "H(+) + NADPH + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 H2O + NADP(+)"}, {"i": "EC:1.14.19.n4", "l": "\"Stearoyl-CoA 9-desaturase (NADPH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865482", "l": "KMT2A (MLL) binds RUNX1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937369", "l": "ATAD2 binds ESR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029473", "l": "Branching and elongation of mother and daughter filaments (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174235", "l": "Association of Emi1 with Cdc20 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50029", "l": "H2O + tetradecanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + tetradecanoyl-4'-phosphopantetheine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004732", "l": "pyridoxal oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28307", "l": "beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose => beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13344", "l": "a menaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + an 8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43393", "l": "1D-myo-inositol 1,3,4-trisphosphate + H2O => 1D-myo-inositol 1,3-bisphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5688786", "l": "ATXN3 binds RAD23 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218642", "l": "PTK2 autophosphorylates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671872", "l": "Phosphorylated LEP:LEPR:JAK2 Binds SH2B1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.295", "l": "\"Momilactone-A synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008140", "l": "cAMP response element binding protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69299", "l": "CDT1 binds geminin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202129", "l": "HSP90 binds eNOS:Caveolin-1:CaM complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433488", "l": "Phosphorylation of SHP2 by SFKs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71495", "l": "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047262", "l": "polygalacturonate 4-alpha-galacturonosyltransferase activity"}, {"i": "MetaCyc:2.4.1.43-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42031", "l": "NAD(+) + ursodeoxycholate <=> 7-oxolithocholate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202331", "l": "Recruitment of PLC-gamma1 to SLP-76 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58521", "l": "(19S)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] => akuammicine + formate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47071", "l": "4alpha-formyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 <=> 4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373087", "l": "Receptor CCR6 binds CCL20 ligand (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21444", "l": "3-(2-hydroxyphenyl)propanoate + NAD(+) = H(+) + NADH + trans-2-coumarate"}, {"i": "EC:1.3.1.11", "l": "\"2-coumarate reductase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070700", "l": "BMP receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62220", "l": "phyllostine = neopatulin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70494", "l": "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9640167", "l": "RRAGA,B exchanges GDP for GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417829", "l": "P2RY12 binds ADP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982645", "l": "GRKs bind ADRB2:Catecholamine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853792", "l": "RET tyrosine phosphorylation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32746", "l": "L-homocysteine + O-acetyl-L-serine <=> acetate + H(+) + L,L-cystathionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41616", "l": "D-ribose 2,5-bisphosphate + H2O = D-ribose 5-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418859", "l": "Phosphorylation of Unc5C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949145", "l": "VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710263", "l": "GZMB cleaves GSDME (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20998", "l": "(3E)-2-oxohex-3-enedioate + NH4(+) => (2Z,4E)-2-aminomuconate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433506", "l": "Phosphorylation of APS (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1500761", "l": "Nitrogen dioxide is reduced to NO by F420 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-429157", "l": "ABCC4 accumulation of dense granule contents (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46023", "l": "[pyruvate, water dikinase] + ADP <=> [pyruvate, water dikinase]-phosphate + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32625", "l": "6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH => L-threo-tetrahydrobiopterin + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-392530", "l": "p-S400-Cot phosphorylates NIK (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005085", "l": "guanyl-nucleotide exchange factor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43796", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61130", "l": "H(+) + H2O + myricetin + oxidized [NADPH--hemoprotein reductase] => O2 + quercetin + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64908", "l": "CTP + 2 H2O = CMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404135", "l": "RBP4 binds atROL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110215", "l": "Cleavage of uracil by UNG glycosylase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33995", "l": "gamma-L-glutamyl-butirosin B = 5-oxo-L-proline + butirosin B"}, {"i": "EC:4.3.2.6", "l": "\"Gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57917", "l": "ATP + L-aspartyl-tRNA(Asn) => 4-phosphooxy-L-aspartyl-tRNA(Asn) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40660", "l": "1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol => 1-O-hexadecylglycerone 3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11175", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine <=> (6S)-5,6,7,8-tetrahydrofolate + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5671993", "l": "CIT-3 binds DLG4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399978", "l": "Protein kinase C, alpha type phosphorylates MARCKS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641229", "l": "TLE oligomerizes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42585", "l": "1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O => 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-350604", "l": "Agmatine + H2O <=> putrescine + urea (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047639", "l": "alcohol oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31013", "l": "camelliol C => (S)-2,3-epoxysqualene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120091", "l": "jasmonic acid hydrolase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40315", "l": "glutaryl-CoA + O2 = (2E)-glutaconyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47573", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1b (d18:1(4E)) => CMP + ganglioside GT1b (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28144", "l": "streptothricin D acid => H2O + streptothricin D"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17997", "l": "Co-precorrin-2 + S-adenosyl-L-methionine = Co-precorrin-3 + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.151", "l": "\"Cobalt-factor II C(20)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097365", "l": "stretch-activated, cation-selective, calcium channel activity involved in regulation of cardiac muscle cell action potential"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018493", "l": "formylmethanofuran dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14276", "l": "A + H2O + spermidine <=> 4-aminobutanal + AH2 + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190265", "l": "FGFR4 binds to FGF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37002", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31829", "l": "(+)-gamma-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25148", "l": "(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde => H(+) + H2O + quinolinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12364", "l": "1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = a quinol + beta-nicotinamide D-riboside"}, {"i": "EC:1.10.5.1", "l": "\"Ribosyldihydronicotinamide dehydrogenase (quinone)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22529", "l": "a flavonol 3-O-beta-D-glucoside + UDP-beta-L-rhamnose => a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507868", "l": "Aquaporins passively transport water into cells (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31128", "l": "3-O-methylgallate + O2 => 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57329", "l": "acetyl-CoA + N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein] => CoA + H(+) + N-terminal N-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25322", "l": "N-methylethanolamine phosphate + S-adenosyl-L-methionine => H(+) + N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015485", "l": "cholesterol binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66294", "l": "an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+) => an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204958", "l": "NRAGE sequesters CHE1 in the cytoplasm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50764", "l": "4-amino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine = 4-methylamino-4-dedimethylamino-anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50036", "l": "choloyl-CoA + H2O = adenosine 3',5'-bisphosphate + choloyl-4'-phosphopantetheine + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46917", "l": "H2O + juvenile hormone I => H(+) + juvenile hormone I carboxylate + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981353", "l": "RASA1 stimulates RAS GTPase activity (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69005", "l": "Cdc6 protein is phosphorylated by CDK (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.211", "l": "\"Endo-(1->3)-fucoidanase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16815", "l": "anthranilate + H(+) + L-alanine => H2O + L-kynurenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30208", "l": "H2O + methylamine + 2 oxidized [amicyanin] => formaldehyde + 2 H(+) + NH4(+) + 2 reduced [amicyanin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35800", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O => 7,8-dihydroneopterin 3'-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10379", "l": "ATP + Cu(2+)(in) + H2O <=> ADP + Cu(2+)(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18549", "l": "[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + H(+) + UDP"}, {"i": "EC:2.4.1.11", "l": "\"Glycogen(starch) synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25375", "l": "a 2-hydroxy-3-methyl fatty acyl-CoA = 2-methyl-branched fatty aldehyde + formyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45501", "l": "[allophycocyanin beta-subunit]-Cys(84)-phycocyanobilin => (2R,3E)-phycocyanobilin + apo-[allophycocyanin beta-subunit]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9017491", "l": "RHOJ GEFs activate RHOJ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700171", "l": "Active ALK phosphorylates PLCG1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032896", "l": "palmitoyl-CoA 9-desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42241", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + tetradecanoyl-CoA => 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59450", "l": "dodecanal + H(+) + NADPH => dodecan-1-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8940100", "l": "CDK1 phosphorylates VCPIP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983696", "l": "The Immunoglobulin of the BCR binds antigen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201630", "l": "Caspase-mediated cleavage of Acinus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139899", "l": "Sequestration of BAD protein by 14-3-3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9640167", "l": "RRAGA,B exchanges GDP for GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33960", "l": "2-oxoglutarate + neomycin C => 6'''-deamino-6'''-oxoneomycin C + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35564", "l": "H2O + N-(9Z-hexadecenoyl) ethanolamine => (9Z)-hexadecenoate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46838", "l": "4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42620", "l": "(Z)-2-methylureidoacrylate + H(+) + H2O = (Z)-2-methylaminoacrylate + CO2 + NH4(+)"}, {"i": "RHEA:42624", "l": "(Z)-3-ureidoacrylate + H(+) + H2O = (Z)-3-aminoacrylate + CO2 + NH4(+)"}, {"i": "EC:3.5.1.110", "l": "\"Ureidoacrylate amidohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982637", "l": "Opsins binds G alpha-t (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20642", "l": "H2O + L-histidinol + 2 NAD(+) => 3 H(+) + L-histidine + 2 NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322125", "l": "Defective MMAB does not transfer adenosyl group from ATP to B12s (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444691", "l": "Prokineticin receptors bind prokineticin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029680", "l": "Caspase-7 translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63351", "l": "ATP + L-amino acyl-L-cysteinyl-[protein] <=> (1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14362", "l": "H2O + O2 + S-prenyl-L-cysteine => 3-methyl-2-butenal + H2O2 + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41859", "l": "3-oxodecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxydecanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804266", "l": "CHEK2 phosphorylates TTC5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60358", "l": "anthranilate + H(+) + octanoate => H2O + N-octanoylanthranilate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854303", "l": "TBC1D11 binds RAB6 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5615668", "l": "AKR1C3 reduces atRAL to atROL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23634", "l": "2-oxoglutarate + CO2 + NADH => D-threo-isocitrate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37726", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17725", "l": "(2S,3S)-2-methylcitrate = 2-methyl-cis-aconitate + H2O"}, {"i": "EC:4.2.1.79", "l": "\"2-methylcitrate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14255", "l": "diphosphate + GDP + H(+) => guanosine 3',5'-bis(diphosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58238", "l": "H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein] => L-tyrosyl-[protein] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37633", "l": "1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63603", "l": "H2O + neocasomorphin <=> L-isoleucine + neocasomorphin-(1-5)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050003", "l": "deoxycytidylate C-methyltransferase activity"}, {"i": "KEGG.REACTION:R01670"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983307", "l": "IL15 binds IL15RA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789160", "l": "Hydrogen peroxide and Fe2+ react to hydroxyl, hydroxide and Fe3+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656893", "l": "OPN1MW binds 11cRAL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610760", "l": "GLI1 is degraded by the proteasome after ubiquitination by ITCH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5213464", "l": "RIPK1 is phosphorylated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33858", "l": "an inositol-1-phosphophytoceramide + GDP-alpha-D-mannose <=> a mannosylinositol-1-phosphophytoceramide + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418091", "l": "F2R binds ARRB1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004048", "l": "anthranilate phosphoribosyltransferase activity"}, {"i": "MetaCyc:PRTRANS-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "53.991960603245126", "identifiers": [{"i": "GO:0016614", "l": "oxidoreductase activity, acting on CH-OH group of donors"}, {"i": "REACT:R-HSA-1500781", "l": "Fgd1 reactivates F420 (Homo sapiens)"}, {"i": "EC:1.1.-.-", "l": "\"Acting on the CH-OH group of donors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63057", "l": "acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine => 5-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61458", "l": "(1S,10S,10aS)-3-(CONH2)-9-Cl-1-(Me2N)-3,3a,4,10-(HO)4-10-Me-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracen-6-olate + CO + H2O + NADP(+) => 7-chlorotetracycline + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174202", "l": "Degradation of multiubiquitinated Securin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36288", "l": "H(+) + NADPH + O2 + theobromine => 7-methylxanthine + formaldehyde + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40746", "l": "(20S)-ginsenoside Rd + 2 H2O <=> (20S)-ginsenoside C-K + 2 D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696564", "l": "USP25 deubiquitinates DDX58 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60030", "l": "4-terpineol + diphosphate => (2E)-geranyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950480", "l": "Expression of annexin A2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12517", "l": "(2E,6E)-farnesyl diphosphate => (+)-(R)-germacrene A + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17640", "l": "squalene <=> hop-22(29)-ene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48154", "l": "ganglioside GM1 (d18:1(4E)/18:0) + N-acetylneuraminate => ganglioside GD1b(d18:1(4E)/18:0) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42695", "l": "[(1->4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate <=> [(1->4)-alpha-D-glucosyl](n+2) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58944", "l": "6 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 12 H(+) + malonyl-CoA + 6 NADPH = 7 CO2 + 8 CoA + demethyldeoxyspectinabilin + 5 H2O + 6 NADP(+)"}, {"i": "EC:2.3.1.290", "l": "\"Spectinabilin polyketide synthase system\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49711", "l": "nocardicin G + S-adenosyl-L-methionine <=> H(+) + isonocardicin C + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51582", "l": "a fatty acyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => a fatty acid(out) + ATP(in) + CoA(in) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25604", "l": "4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O <=> 2-(2-methylsulfanyl)ethylmalate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39033", "l": "a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33283", "l": "2-hydroxycyclohexan-1-one + NADPH + O2 = 6-oxohexanoate + H2O + NADP(+)"}, {"i": "EC:1.14.13.66", "l": "\"2-hydroxycyclohexanone 2-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27789", "l": "2-oxoglutarate + CoA + NAD(+) <=> CO2 + NADH + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30392", "l": "4-methylsulfanyl-2-oxobutanoate + L-glutamine => 2-oxoglutaramate + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45071", "l": "(R)-carnitine + an acyl-CoA <=> CoA + O-acyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32078", "l": "geranylgeranyl diphosphate + H2O <=> (13E)-labda-7,13-dien-15-ol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36955", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + pentadecanoyl-CoA = (9Z)-pentadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032563", "l": "dADP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48537", "l": "1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O => 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050339", "l": "thymidine-triphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102042", "l": "dehydroquinate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13918", "l": "(-)-menthol + NADP(+) => (1R,4S)-menthone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654515", "l": "KAL1 binds HS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114544", "l": "p115-RhoGEF activation of RHOA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33827", "l": "ergosterol = vitamin D2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1606602", "l": "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047336", "l": "5-methyldeoxycytidine-5'-phosphate kinase activity"}, {"i": "MetaCyc:2.7.4.19-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578777", "l": "DMPK phosphorylates PLN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000310", "l": "AURKA phosphorylates PLK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295599", "l": "SPRY2 translocates to the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73932", "l": "Resynthesis of excised residue by POLB (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.23.1.-", "l": "\"With NADH or NADPH as donor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22757", "l": "a long-chain primary fatty alcohol + O2 => a long-chain fatty aldehyde + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52416", "l": "3-dehydro-4-O-phospho-D-erythronate + H(+) = CO2 + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57781", "l": "2-chloro-4-nitrotoluene + NADH + O2 => 3-chloro-4-methylcatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615721", "l": "HSPA8 binds substrate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52525", "l": "O2 + prostaglandin A1 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy prostaglandin A1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32348", "l": "2 S-adenosyl-L-methionine + tricetin => 3',5'-di-O-methyltricetin + 2 H(+) + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.18"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14654", "l": "a nucleoside 3',5'-cyclic phosphate + H2O => a nucleoside 5'-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783681", "l": "LIF binds LIFR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47642", "l": "4 H(+) + N(6)-dimethyladenosine(1785)/N(6)-dimethyladenosine(1786) in 18S rRNA + 4 S-adenosyl-L-homocysteine => adenosine(1785)/adenosine(1786) in 18S rRNA + 4 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25819", "l": "H2O + norspermine + O2 <=> 3-aminopropanal + H2O2 + norspermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24617", "l": "17beta-estradiol + NADP(+) => estrone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41639", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + H2O <=> 1-O-(1Z-alkenyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938987", "l": "BLK gene expression is stimulated by the complex of RUNX1 and ELF1, ELF2 or PAX5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14623", "l": "lanosterol => (S)-2,3-epoxysqualene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209815", "l": "Tyrosine is monoiodinated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620663", "l": "EGR1 binds the VGF gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42834", "l": "(S)-3-acetyloctanal + CO2 => (2E)-octenal + H(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.12"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2106615", "l": "Removal of siRNA passenger strand (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58517", "l": "(19S)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] => 15alpha-stemmadenine intermediate I + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617661", "l": "MAFB:JUN and EGR2 activate HOXB3 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50660", "l": "3-(3-methylsulfanyl)propylmalate = 2-(2-methylsulfanyl)propylmaleate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12531", "l": "N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate <=> [hyaluronan](n+1) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36517", "l": "3-oxohexacosanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + tetracosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46174", "l": "AMP + butanoyl-CoA + diphosphate => ATP + butanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75028", "l": "Phosphorylation of Wee1 kinase by Chk1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42074", "l": "(4S)-4-hydroxy-2-oxoheptanedioate => (4Z)-2-oxohept-4-enedioate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63599", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030059", "l": "aralkylamine dehydrogenase (azurin) activity"}, {"i": "RHEA:47796", "l": "an aralkylamine + H2O + 2 oxidized [azurin] = an aromatic aldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]"}, {"i": "EC:1.4.9.2", "l": "\"Aralkylamine dehydrogenase (azurin)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340226", "l": "CYGB dioxygenates NO (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61818", "l": "16,17-didehydropregnenolone 3-beta-D-glucoside + H(+) + UDP => 16,17-didehydropregnenolone + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18093", "l": "5,6-dihydrouracil + NADP(+) = H(+) + NADPH + uracil"}, {"i": "RHEA:58284", "l": "5,6-dihydrothymine + NADP(+) = H(+) + NADPH + thymine"}, {"i": "EC:1.3.1.2", "l": "\"Dihydropyrimidine dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-398188", "l": "PLC beta is activated by G alpha (q) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448627", "l": "Interleukin-35 translocates from the ER lumen to the extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48382", "l": "a neolactoside IV(3)-alpha-Gal,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+) => alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730842", "l": "PI3K associates with phosphorylated GAB2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140226", "l": "RNA topoisomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56637", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786650", "l": "DDHD1,2 hydrolyse PA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68595", "l": "ORC2 binds ORC3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4086083", "l": "SUMOylation of ING2 with SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60436", "l": "3-methylbutyl acetate + H2O = 3-methylbutanol + acetate + H(+)"}, {"i": "EC:3.1.1.112", "l": "\"Isoamyl acetate esterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695838", "l": "Ligand-independent dimerization of FLT3 mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013284", "l": "NOTCH3-ligand complex is cleaved to produce NEXT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686920", "l": "PELI1 ubiquitinates RIPK3 at K363 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008987", "l": "quinolinate synthetase A activity"}, {"i": "RHEA:25888", "l": "dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate"}, {"i": "MetaCyc:QUINOLINATE-SYNTHA-RXN"}, {"i": "EC:2.5.1.72", "l": "\"Quinolinate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19881", "l": "GTP + L-lysyl-[protein] = diphosphate + H(+) + N(epsilon)-GMP-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419253", "l": "5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5660660", "l": "p300 acetylates RELA subunit (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34400", "l": "9-cis-beta-carotene + O2 => 9-cis-10'-apo-beta-carotenal + beta-ionone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50913", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-L-ribitol => 4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928578", "l": "EPH receptors autophosphorylate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.217", "l": "\"3-dehydrotetronate 4-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27645", "l": "adenosine + phosphate <=> adenine + alpha-D-ribose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647660", "l": "GSDME (1-270) binds PIPs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690023", "l": "NUBPL binds 4Fe-4S (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63370", "l": "ADP + H(+) + phosphate + spermine(in) => ATP + H2O + spermine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56697", "l": "D-ribulose 5-phosphate + L-tryptophan => (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030600", "l": "feruloyl esterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16280", "l": "H2O + indole-3-acetaldehyde + O2 <=> (indol-3-yl)acetate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004470", "l": "malic enzyme activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38776", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936665", "l": "OPS is added to the carrier sulfide (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034013", "l": "aliphatic aldoxime dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52128", "l": "adenosine-5'-diphospho-5'-(DNA) + H2O = AMP + 2 H(+) + phospho-5'-(DNA)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005330", "l": "dopamine:sodium symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58408", "l": "NADP(+) + undecan-1-ol = H(+) + NADPH + undecanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40073", "l": "NH4(+) + pyruvate => 2-aminoprop-2-enoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190687", "l": "Connexin oligomerization in  ER-Golgi-Intermediate Compartment (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177930", "l": "GAB1 phosphorylation by EGFR kinase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62497", "l": "ATP + H(+) + L-arginine => diphosphate + L-arginyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811427", "l": "COPI vesicle uncoating at the ER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849878", "l": "PSD-95 binds NMDA receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62189", "l": "9alpha-copalyl diphosphate => diphosphate + syn-isopimara-7,15-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35485", "l": "4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + S-adenosyl-L-homocysteine => 5alpha-cholest-7-en-3-one + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102920", "l": "acyl coenzyme A: isopenicillin N acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177923", "l": "Sustained activation of SRC kinase by SHP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190682", "l": "Connexin synthesis (generic) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59447", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene + A <=> 1,1'-dihydroxy-3,4-didehydro-1,2-dihydrolycopene + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66378", "l": "D-erythrose + phosphate => D-erythrose 4-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61959", "l": "1-O-octadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.25", "l": "\"Inositol-phosphate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24621", "l": "NAD(+) + octan-1-ol => H(+) + NADH + octanal"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050596", "l": "vinorine hydroxylase activity"}, {"i": "RHEA:17257", "l": "O2 + reduced [NADPH--hemoprotein reductase] + vinorine = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + vomilenine"}, {"i": "EC:1.14.14.104", "l": "\"Vinorine hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048529", "l": "magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21561", "l": "3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol => 1,4-dithiothreitol + 2,3-epoxyphylloquinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853496", "l": "SCF:FBXL7 binds AURKA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36197", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a carboxylate + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004335", "l": "galactokinase activity"}, {"i": "RHEA:13553", "l": "alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate + H(+)"}, {"i": "EC:2.7.1.6", "l": "\"Galactokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50775", "l": "H2O + nitroethane + O2 <=> acetaldehyde + H(+) + H2O2 + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60390", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) => Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295622", "l": "SPRY2 binds CBL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33877", "l": "(9Z)-octadecenoate + cholesterol + H(+) => cholesteryl (9Z-octadecenoate) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0035064", "l": "methylated histone binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24810", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate => 3-methyl-2-oxobutanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000112", "l": "Endosomal TCII:Cbl translocates to lysosome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14349", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose = an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP"}, {"i": "EC:2.4.1.37", "l": "\"Fucosylgalactoside 3-alpha-galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-392064", "l": "G alpha (z) inhibits adenylate cyclase (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28315", "l": "baicalein + UDP-alpha-D-glucuronate => baicalin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635845", "l": "GLI proteins bind CDC73 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12914", "l": "(R)-lipoate + ATP + H(+) => (R)-lipoyl-5'-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63032", "l": "a fatty acylamide + H2O = a fatty acid + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17278", "l": "6-phospho-D-gluconate => 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49093", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H2O => H(+) + hexadecanoate + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0016500", "l": "protein-hormone receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873926", "l": "IFNG dimer binds IFNGR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156661", "l": "Formation of Exon Junction Complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678925", "l": "NR3C1 binds NR3C1 agonists (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654425", "l": "Activated FGFR4 binds SHC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66400", "l": "ATP + glutathione(in) + glycocholate(in) + H2O = ADP + glutathione(out) + glycocholate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48276", "l": "H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = a beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32631", "l": "erythromycin D + H(+) + NADPH + O2 = erythromycin C + H2O + NADP(+)"}, {"i": "EC:1.14.13.154", "l": "\"Erythromycin 12 hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27991", "l": "1-deoxy-D-xylulose + ATP => 1-deoxy-D-xylulose 5-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62018", "l": "3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP => L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2167924", "l": "SMAD7:SMURF1 complex binds XPO1 (CRM1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3239014", "l": "MAPKAPK5 phosphorylates TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41673", "l": "1-O-hexadecyl-sn-glycerol + ATP => 1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50353", "l": "3 (R)-methylmalonyl-CoA + 9 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 6 NADPH => 3 CO2 + 3 CoA + 3 H2O + 6 NADP(+) + trimethylated-mycocerosoyl-[mycocerosate synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57464", "l": "(E)-caffeate + UDP-alpha-D-glucose = 1-O-[(E)-caffeoyl]-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618093", "l": "ATP hydrolysis by HSP90 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16759", "l": "H(+) + NADPH + trypanothione disulfide => NADP(+) + trypanothione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.2.-.-", "l": "\"Transferring aldehyde or ketonic groups\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265968", "l": "Association of RAD51 with BRCA1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170159", "l": "Translocation of Cdc25 to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32082", "l": "(13E)-labda-7,13-dien-15-yl diphosphate + H2O <=> (13E)-labda-7,13-dien-15-ol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2484822", "l": "Kinetochore assembly (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.174"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36391", "l": "cholesterol + NADP(+) = cholesta-5,24-dien-3beta-ol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65452", "l": "ethanol + hexanoyl-CoA = CoA + ethyl hexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55716", "l": "(S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(2'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O = (9Z)-octadecenoate + (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28461", "l": "biotin(in) <=> biotin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36982", "l": "(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19352", "l": "(R)-4-dehydropantoate + H2O + NAD(+) <=> (R)-3,3-dimethylmalate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53155", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109813", "l": "GRB2-1 binds SOS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45893", "l": "an N-acylsphing-4-enine + CDP-ethanolamine => an N-acylsphing-4-enine 1-phosphoethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10601", "l": "prostaglandin H2 => prostaglandin D2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67001", "l": "2-methylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 3 CO2 + 4 CoA + phlorisobutanophenone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32099", "l": "S-adenosyl-L-methionine + TRIBOA beta-D-glucoside = DIMBOA beta-D-glucoside + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.241", "l": "\"2,4,7-trihydroxy-1,4-benzoxazin-3-one-glucoside 7-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936747", "l": "cleavage of L-cysteine from carrier protein (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072571", "l": "mono-ADP-D-ribose binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29711", "l": "cadaverine(in) + H(+)(in) = cadaverine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35360", "l": "3-hydroxyisoheptadecanoyl-CoA => (2E)-15-methylhexadecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0051735", "l": "GTP-dependent polynucleotide kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53816", "l": "hydrogen sulfide + O-succinyl-L-serine = L-cysteine + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937989", "l": "RUNX1 binds PRC1 complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853444", "l": "AURKA phosphorylates PHLDA1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61185", "l": "quercitrin + UDP-beta-L-rhamnose => H(+) + quercetin 3,7-bis-O-alpha-L-rhamnoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867047", "l": "PTPN3 dephosphorylates EPS15 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018637", "l": "1-hydroxy-2-naphthoate hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112037", "l": "Inactivation of PLC beta (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193665", "l": "MYD88 dissociates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "57.869332421966433", "identifiers": [{"i": "GO:0003676", "l": "nucleic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2995376", "l": "BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54435", "l": "2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 <=> a 4-H-anthocyanidin with a 3-hydroxy group + CO2 + 2 H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61060", "l": "beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + UDP-alpha-D-galactose = a neolactoside nLc4Cer + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187575", "l": "Ubiquitination of phospho-p27/p21 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110011", "l": "Binding of Grb10 to the insulin receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050066", "l": "lysine 2,3-aminomutase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781814", "l": "USP19 deubiquitinates RNF123 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32805", "l": "ADP + H(+) + phosphate + urea(in) => ATP + H2O + urea(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015382", "l": "sodium:sulfate symporter activity"}, {"i": "REACT:R-HSA-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Homo sapiens)"}, {"i": "REACT:R-HSA-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36763", "l": "alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50372", "l": "an N-acylsphingoid base 1-phosphate(in) = an N-acylsphingoid base 1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17473", "l": "GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)"}, {"i": "EC:3.5.4.16", "l": "\"GTP cyclohydrolase I\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0032131", "l": "alkylated DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60041", "l": "H2O + N(2)-[(2E)-3-methylhex-2-enoyl]-L-glutaminate => (2E)-3-methylhex-2-enoate + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606561", "l": "MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18532", "l": "3-methylbutanol + NAD(+) <=> 3-methylbutanal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31449", "l": "5-aminopentanoate + CO2 + H2O => 6-amino-2-oxohexanoate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202731", "l": "JAM3 dimerises (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855648", "l": "SALM3 binds LAR-RPTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5653936", "l": "Formation of Ragulator complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "74.378130331796413", "identifiers": [{"i": "GO:0099094", "l": "ligand-gated cation channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5627072", "l": "RHOQ binds GOPC:CFTR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13638", "l": "H(+) + methane + NADH + O2 => H2O + methanol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70982", "l": "Fumarate + H2O <=> (S)-Malate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36642", "l": "3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-methionine <=> 3-O-methylphospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4839635", "l": "CTNNB1 S37 mutants aren't phosphorylated by GSK3beta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34502", "l": "1-deoxypentalenate + 2 H(+) + O2 + reduced 2[4Fe-4S]-[ferredoxin] <=> H2O + oxidized 2[4Fe-4S]-[ferredoxin] + pentalenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66076", "l": "2-oxopentanoate + L-kynurenine = H2O + kynurenate + L-2-aminopentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58100", "l": "1-(15Z-tetracosenoyl)-glycerol + H2O = (15Z)-tetracosenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432129", "l": "FGR binds and phosphorylates LRP8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928614", "l": "EFNB:GRB4 binds GIT1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25344", "l": "carbamate + NH4(+) => H2O + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29967", "l": "2'-deoxyuridine(in) + H(+)(in) = 2'-deoxyuridine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350901", "l": "Iodide is organified (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111956", "l": "Calmodulin activates Cam-PDE 1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047293", "l": "4-hydroxybenzoate nonaprenyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34047", "l": "6'''-deamino-6'''-hydroxyneomycin C + O2 = 6'''-deamino-6'''-oxoneomycin C + H2O2"}, {"i": "EC:1.1.3.44", "l": "\"6'''-hydroxyneomycin C oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5444516", "l": "Formation of MSH2:MSH6 Complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444661", "l": "HCAR2 binds HCAR2 ligands (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20323", "l": "1-pyrroline-2-carboxylate + H(+) + NADH => L-proline + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203973", "l": "Vesicle budding (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62767", "l": "4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50191", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 <=> N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-378952", "l": "Thyrotropin is a heterodimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9005585", "l": "MECP2 mutants P302R,K304E,K305R,R306C,(R306H) do not bind NCoR/SMRT complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69299", "l": "CDT1 binds geminin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40428", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9626928", "l": "CREBBP binds FOXO1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26543", "l": "(R)-piperazine-2-carboxamide + H2O => (R)-piperazine-2-carboxylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.7", "l": "\"Inulinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46751", "l": "carboxyphosphate + NH4(+) <=> carbamate + 2 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610760", "l": "GLI1 is degraded by the proteasome after ubiquitination by ITCH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31273", "l": "CO2 + H2O + NAD(+) + naphthalene-1,2-diol => 1-hydroxy-2-naphthoate + 2 H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691363", "l": "nsp12 binds nsp7 and nsp8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13355", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+) => 4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109701", "l": "PDPK1 binds PIP3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13476", "l": "H2O + L-tryptophan + NAD(+) <=> H(+) + indole-3-pyruvate + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9011543", "l": "DCA binds PDK2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56330", "l": "5'-triphosphoadenylyl-(2'->5')-adenosine + AMP + H(+) => 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694499", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432946", "l": "PARVB/Affixin interacts with alpha PIX (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046316", "l": "gluconokinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018804", "l": "RAC3 GEFs activate RAC3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2473594", "l": "Collagen type II degradation by MMP15 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035248", "l": "alpha-1,4-N-acetylgalactosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102326", "l": "2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate hydrolase activity"}, {"i": "MetaCyc:RXN-13171"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.5", "l": "\"L-threonine aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655142", "l": "RCHY1 binds POLH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681840", "l": "RTC synthesizes SARS-CoV-1 plus strand genomic RNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45432", "l": "H2O + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = H(+) + N-(9Z-octadecenoyl) ethanolamine + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36436", "l": "a 1,2-diacyl-sn-glycero-3-phosphate(in) => a 1,2-diacyl-sn-glycero-3-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051777", "l": "ent-kaurenoate oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.73", "l": "\"Lipopolysaccharide glucosyltransferase II\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70692", "l": "ornithine => putrescine + CO2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1370505", "l": "PRLR is phosphorylated at Ser-349 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20415", "l": "glucuronoxylan 4-O-methyl-D-glucuronate + n H(+) + n S-adenosyl-L-homocysteine => glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389919", "l": "Grb2 binds pBTLA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866269", "l": "ARRB bind GPCRs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047812", "l": "D-amino-acid N-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38408", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O => (9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19653", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NAD(+) = CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH"}, {"i": "RHEA:19657", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NADP(+) = CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH"}, {"i": "EC:1.17.1.1", "l": "\"CDP-4-dehydro-6-deoxyglucose reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51297", "l": "a quinone + H2O + L-methionyl-[protein] => a quinol + L-methionyl-(R)-S-oxide-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662837", "l": "p-S,T-ADAM17(215-827):Zn2+ cleaves CD163 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-398040", "l": "Gbeta:gamma activation of PLC beta (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23143", "l": "beta-nicotinamide D-ribonucleotide + H2O <=> D-ribose 5-phosphate + H(+) + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043852", "l": "monomethylamine methyltransferase activity"}, {"i": "RHEA:26059", "l": "[Co(I) methylamine-specific corrinoid protein] + H(+) + methylamine = [methyl-Co(III) methylamine-specific corrinoid protein] + NH4(+)"}, {"i": "EC:2.1.1.248", "l": "\"[Methylamine--corrinoid protein] Co-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191303", "l": "FDPS dimer transfers IPPP to GPP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610408", "l": "GluN1:GluN2B (GRIN1:GRIN2B) di-heterotetramers bind LIN7:CASK:APBA1, DLG1 and KIF17 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4395236", "l": "TP53 binds promoters of MIR34 genes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62872", "l": "(3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + H(+) + NADPH + O2 = H2O + NADP(+) + semiviriditoxin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74258", "l": "XDH oxidizes xanthine to form urate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69152", "l": "Removal of remaining Flap (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10678", "l": "2-isopropylmaleate + H2O => (2R,3S)-3-isopropylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42865", "l": "norspermidine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + norspermine + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29977", "l": "2'-deoxycytidine(out) + H(+)(out) => 2'-deoxycytidine(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797810", "l": "PTPRD binds IL1RAPL1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24270", "l": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH => 2,6-dioxo-6-phenylhexanoate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.93"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694304", "l": "nsp14 binds nsp12 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.10", "l": "\"Pyrimidine-5'-nucleotide nucleosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2752115", "l": "SPP1 (osteopontin) binds CD44 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374896", "l": "Uptake of Noradrenaline (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51223", "l": "1-chloro-2,4-dinitrobenzene + glutathione <=> 2,4-dinitrophenyl-S-glutathione + chloride + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25136", "l": "phosphate + pyridoxamine => H2O + pyridoxamine 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57775", "l": "3-nitrotoluene + NADH + O2 <=> 4-methylcatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43866", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(out) => 1-hexadecanoyl-sn-glycero-3-phosphocholine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5138459", "l": "WNT5A:FZD4 is endocytosed (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-874087", "l": "SGT1 binds HSP90 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2317314", "l": "AKT binds PDPK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70427", "l": "PGM:Mg2+ isomerise G1P to G6P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29750", "l": "3-phenylpropanoate(in) <=> 3-phenylpropanoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25881", "l": "2 L-dopa + O2 => 2 3-(3,4-dihydroxyphenyl)pyruvate + 2 NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102871", "l": "1-16:0-2-18:1-phosphatidylcholine desaturase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034796", "l": "adipate-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19245", "l": "N-phenylhydroxylamine = 2-aminophenol"}, {"i": "EC:5.4.4.1", "l": "\"(Hydroxyamino)benzene mutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25659", "l": "(R)-pulegone + O2 + reduced [NADPH--hemoprotein reductase] => (R)-menthofuran + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19021", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP"}, {"i": "EC:2.4.1.40", "l": "\"Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210309", "l": "Interaction of DAP12 and KIR2DS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62410", "l": "1,3,3'-tri-O-methyl-4alpha-mannobiose + H(+) + S-adenosyl-L-homocysteine => 3,3'-di-O-methyl-4alpha-mannobiose + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102040", "l": "fumarate reductase (menaquinone)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54003", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65289", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008466", "l": "glycogenin glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22280", "l": "O-demethylpuromycin + S-adenosyl-L-methionine = H(+) + puromycin + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.38", "l": "\"O-demethylpuromycin O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9681294", "l": "IL6R binds IL6R inhibitors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9688459", "l": "RIPK3 binds HSP90:CDC37 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22643", "l": "NADP(+) + sphinganine <=> 3-oxosphinganine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211356", "l": "Anthrax lef cleaves target cell MAP2K2 (MEK2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25491", "l": "(2E)-geranyl diphosphate <=> (1S,5S)-alpha-pinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14786", "l": "RNA(n) + UTP => diphosphate + RNA(n)-3'-uridine ribonucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1467466", "l": "ABCA4 mediates atRAL transport (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27748", "l": "CO2 + cysteamine => H(+) + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701488", "l": "Active ALK phosphorylates JAK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-532603", "l": "Nephrin mediated activation of N-WASP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63029", "l": "(15Z)-tetracosenamide + H2O => (15Z)-tetracosenoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205306", "l": "Interaction of SHP1 and KIT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16906", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O => a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56291", "l": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54380", "l": "(2E,6E)-farnesyl diphosphate + H2O = 5-hydroxy-alpha-gurjunene + diphosphate"}, {"i": "EC:4.2.3.184", "l": "\"5-hydroxy-alpha-gurjunene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668597", "l": "DNA polymerase:primase binds G-strand of the telomere (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33003", "l": "(+)-amorpha-4,11-diene + O2 + reduced [NADPH--hemoprotein reductase] = (+)-artemisinic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61821", "l": "3beta-hydroxy-5alpha-androstan-17-one + UDP-alpha-D-glucose => epiandrosterone 3-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418850", "l": "Activation of Cdc42 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10090", "l": "6(F)-alpha-D-galactosylsucrose + H(+) + UDP => sucrose + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53732", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminosalicylate = 2-hydroxy-7,8-dihydropteroate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47298", "l": "(2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein] => dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10648", "l": "2-hydroxycyclohexan-1-one + H(+) + NADPH + O2 = 6-hydroxyhexan-6-olide + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50920", "l": "2 2-iminio-3-(indol-3-yl)propanoate + H2O2 = chromopyrrolate + H(+) + 2 H2O + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351894", "l": "Caspase mediated cleavage of BAP31 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9656893", "l": "OPN1MW binds 11cRAL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8981926", "l": "RAC1 and CDC42 activate PAK3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43766", "l": "AMP + chenodeoxycholoyl-CoA + diphosphate => ATP + chenodeoxycholate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3878123", "l": "Initiation of SAHF formation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218815", "l": "p-6Y-VEGFR2 binds NCK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9640195", "l": "RRAGA,B hydrolyzes GTP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15910", "l": "2-oxoglutarate + O2 + taurine => aminoacetaldehyde + CO2 + H(+) + succinate + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61113", "l": "(2R,3R)-dihydrokaempferol + O2 + reduced [NADPH--hemoprotein reductase] => (2R,3R)-dihydroquercetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12284", "l": "3-hydroxy-3-methylglutarate + succinyl-CoA = (3S)-hydroxy-3-methylglutaryl-CoA + succinate"}, {"i": "RHEA:24948", "l": "3-hydroxy-3-methylglutarate + malonyl-CoA = (3S)-hydroxy-3-methylglutaryl-CoA + malonate"}, {"i": "EC:2.8.3.13", "l": "\"Succinate--hydroxymethylglutarate CoA-transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.99.-", "l": "\"With other acceptors\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046976", "l": "histone methyltransferase activity (H3-K27 specific)"}, {"i": "REACT:R-HSA-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012542", "l": "IL37 binds 2x(CASP1(120-197):CASP1(317-404)) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382056", "l": "Crk binds to the active PDGF receptor (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "72.270040348674314", "identifiers": [{"i": "GO:0015085", "l": "calcium ion transmembrane transporter activity"}, {"i": "REACT:R-HSA-2534359", "l": "CatSper Channel Mediated Calcium Transport (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.5.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592244", "l": "AMPK phosphorylates PPARGC1A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418553", "l": "cAMP degradation by Phosphodiesterases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5213464", "l": "RIPK1 is phosphorylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856157", "l": "LAG3 (CD233) binds MHC II (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41035", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + hexadecanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-hexadecanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74986", "l": "Elongation of pre-rRNA transcript (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22277", "l": "2-oxoaldehyde + H2O + NAD(+) => a 2-oxocarboxylate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0140699", "l": "cyclic GMP-AMP synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694436", "l": "MIA2 and MIA3 dissociate from procollagen VII vesicle (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62276", "l": "3 (R)-2-hydroxy-3-methylbutyrate + 6 ATP + 3 L-phenylalanine + 3 S-adenosyl-L-methionine = 6 AMP + beauvericin + 6 diphosphate + 6 H(+) + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570493", "l": "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.29"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33931", "l": "all-trans-zeaxanthin + O2 = (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal"}, {"i": "EC:1.13.11.65", "l": "\"Carotenoid isomerooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43409", "l": "sphinganine + UDP-alpha-D-galactose => beta-D-galactosyl-(1<->1')-sphinganine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42688", "l": "AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide = A + ergothioneine + NH4(+) + pyruvate"}, {"i": "EC:4.4.1.36", "l": "\"Hercynylcysteine S-oxide lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18064", "l": "5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran <=> methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36142", "l": "(E)-hexadec-2-enoate + ATP + CoA <=> (2E)-hexadecenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38881", "l": "a fatty acid(out) => a fatty acid(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418850", "l": "Activation of Cdc42 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14500", "l": "A + pyridoxine <=> AH2 + isopyridoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20372", "l": "betaine aldehyde + H2O + O2 <=> glycine betaine + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030761", "l": "8-hydroxyquercitin 8-O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018851", "l": "alpha-pinene-oxide decyclase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47360", "l": "decanoate ester + H2O = an aliphatic alcohol + decanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.56", "l": "\"Gamma-humulene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2248891", "l": "Active ARSA translocates to the lysosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24791", "l": "(2E)-2-hydroxypenta-2,4-dienoate + H(+) + succinate => (2E,4Z)-2-hydroxy-6-oxononadienedioate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351412", "l": "Association of MRE11 and NBS1 leads to nuclear localization of MRN complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44100", "l": "H2O + NAD(+) + octanal = 2 H(+) + NADH + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647980", "l": "mature RAS proteins translocate to plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445069", "l": "L1-EGFR trans-heterodimerization (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8987007", "l": "p-STAT1 dimerizes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40866", "l": "FAD + H(+) + heptadecanoyl-CoA <=> FADH2 + trans-2-heptadecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11780", "l": "3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose = 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP"}, {"i": "EC:2.4.1.134", "l": "\"Galactosylxylosylprotein 3-beta-galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35688", "l": "NADP(+) + tetradecasphinganine => 3-oxotetradecasphinganine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31417", "l": "(+)-2-epi-prezizaene + diphosphate => (2Z,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2214351", "l": "PLK1 phosphorylates GORASP1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193668", "l": "p75NTR and RHOA-GDI interact (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41077", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25278", "l": "3',5'-cyclic AMP + H2O => AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18015", "l": "ethylamine + L-glutamate => H2O + N(5)-ethyl-L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62778", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O => 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34128", "l": "(2E)-geranyl diphosphate + olivetolate => cannabigerolate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668904", "l": "Formation of the CTF18 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-453183", "l": "p-Y348-SYK dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801675", "l": "PLK2 phosphorylates NPM1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2768993", "l": "NOTCH1 PEST domain mutants bind JAG2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380949", "l": "AMPK is dephosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29360", "l": "H2O + UMP => phosphate + uridine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35079", "l": "doxorubicin(in) = doxorubicin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30380", "l": "(2E,6E)-farnesyl diphosphate => (+)-beta-chamigrene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-877187", "l": "P2X7 mediates loss of intracellular K+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66154", "l": "CoA + H(+) + N-acetylnoradrenaline => acetyl-CoA + noradrenaline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168394", "l": "STAT5 tyrosine phosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39180", "l": "(2E)-eicosenoyl-CoA + H(+) + NADPH => eicosanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58207", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine <=> dihydroalstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868071", "l": "Clathrin recruits PIK3C2A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38379", "l": "(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41354", "l": "a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58495", "l": "ATP + Fe(III)-enterobactin(out) + H2O <=> ADP + Fe(III)-enterobactin(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26442", "l": "a ubiquinone + ethanol = a ubiquinol + acetaldehyde"}, {"i": "EC:1.1.5.5", "l": "\"Alcohol dehydrogenase (quinone)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354077", "l": "Integrin alphaIIb beta3 activation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15580", "l": "H2O + uridine <=> D-ribose + uracil"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418874", "l": "Recruitment and activation of N-WASP by Cdc42 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165179", "l": "Formation of TSC1:TSC2 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005115", "l": "receptor tyrosine kinase-like orphan receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65866", "l": "5alpha-androstan-1,3,17-trione + AH2 => 5alpha-androst-1-ene-3,17-dione + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38462", "l": "2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + a mycolipenoyl-CoA <=> 2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20689", "l": "chlorogenate + H2O = (E)-caffeate + H(+) + L-quinate"}, {"i": "EC:3.1.1.42", "l": "\"Chlorogenate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19305", "l": "3-hydroxybenzoyl-CoA + 2 H(+) + 3 malonyl-CoA = 2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA"}, {"i": "EC:2.3.1.151", "l": "\"2,3',4,6-tetrahydroxybenzophenone synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033912", "l": "2,6-beta-fructan 6-levanbiohydrolase activity"}, {"i": "MetaCyc:3.2.1.64-RXN"}, {"i": "EC:3.2.1.64", "l": "\"2,6-beta-fructan 6-levanbiohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382056", "l": "Crk binds to the active PDGF receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47450", "l": "(2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (5Z)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10897", "l": "2 H2O + limonin => 2 H(+) + limonoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008107", "l": "galactoside 2-alpha-L-fucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483186", "l": "PC is converted to PS by PTDSS1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60979", "l": "(E)-4-hydroxynon-2-en-1-ol + NAD(+) <=> (E)-4-hydroxynon-2-enal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39722", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetracosanoate <=> 24-hydroxytetracosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29812", "l": "ATP + H2O + thiamine(out) => ADP + H(+) + phosphate + thiamine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.27"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14768", "l": "coelenterazine h + O2 <=> CO2 + excited coelenteramide h monoanion + H(+) + hnu"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13998", "l": "3-methyl-2-oxobutanoate + CoA + NAD(+) => 2-methylpropanoyl-CoA + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45712", "l": "3-dehydrocarnityl-CoA + CoA = acetyl-CoA + N,N,N-trimethylglycyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16238", "l": "[protein]-peptidylproline (omega=180) => [protein]-peptidylproline (omega=0)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388605", "l": "POMC(138-176) binds MC2R (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43054", "l": "3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate => 3-(methylsulfanyl)propanoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49879", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62286", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + 2 AMP + 2 diphosphate + H(+) + H2O + NADP(+) => 2 ATP + L-proline + L-tryptophan + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13779", "l": "5-phospho-beta-D-ribosylamine + ADP + H(+) + phosphate => ATP + D-ribose 5-phosphate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58415", "l": "3 H(+) + hydrogen sulfide + L-aspartate 4-semialdehyde + reduced 2[4Fe-4S]-[ferredoxin] <=> H2O + L-homocysteine + oxidized 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786101", "l": "IL4 binds IL4R:JAK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54772", "l": "ATP + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide = 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42423", "l": "2-oxoglutarate + L-lysine + O2 <=> (4R)-4-hydroxy-L-lysine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25626", "l": "H2O + histamine + O2 => H2O2 + imidazole-4-acetaldehyde + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047411", "l": "2-(acetamidomethylene)succinate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994038", "l": "IRF2 binds the promoters of Interferon alpha and beta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682826", "l": "LGI1 binds ADAM11 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011543", "l": "DCA binds PDK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3296304", "l": "GPR31 is a receptor for 12(S)-HETE (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1474266", "l": "Formation of collagen fibrils (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35150", "l": "(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(in) <=> (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46859", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH <=> 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49774", "l": "CoA + H(+) + N-hexacosanoylglycine => glycine + hexacosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36598", "l": "hydrogen sulfide + NADP(+) <=> NADPH + sulfur"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2995330", "l": "COX10 transforms heme to heme O (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0000984", "l": "bacterial-type RNA polymerase transcription regulatory region sequence-specific DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725357", "l": "NPM-ALK-dependent CEBPB gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003691", "l": "double-stranded telomeric DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62363", "l": "FMNH2 + O2 + uracil <=> (Z)-3-ureidoacrylate + FMN-N(5)-oxide + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46780", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.19.46", "l": "\"sn-1 linoleoyl-lipid 6-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033474", "l": "FGFR2b mutants bind an expanded range of ligands (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0004683", "l": "calmodulin-dependent protein kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31122", "l": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA <=> (2E)-2-methylbut-2-enoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36104", "l": "anthranilate + S-adenosyl-L-methionine => O-methyl anthranilate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676598", "l": "TRAF2:cIAP1/2 complex binds FN14:TWEAK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11582", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+) => a CDP-1,2-diacyl-sn-glycerol + myo-inositol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30145", "l": "CoA + H(+) + octanoate => H2O + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50454", "l": "prostaglandin E3 => prostaglandin H3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59404", "l": "L-homoserine = D-homoserine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140337", "l": "diacylglyceride transfer activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34733", "l": "CoA + H(+) + N-acyl-15-methylhexadecasphing-4-enine => 15-methylhexadecasphing-4-enine + a fatty acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038006", "l": "netrin receptor activity involved in chemoattraction"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59411", "l": "H2O + N-acetyl-L-aspartate <=> acetate + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37023", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (6Z)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654404", "l": "Activated FGFR2 binds SHC1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53770", "l": "allocholoyl-CoA + allodeoxycholate => allocholate + allodeoxycholoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59817", "l": "a long-chain fatty acyl-CoA + a sterol => a sterol ester + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18835", "l": "4-sulfobenzoate + 2 H(+) + NADH => 4-formylbenzenesulfonate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033520", "l": "TYSND1 cleaves TYSND1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682011", "l": "LC3 binds ATG7 dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869683", "l": "oxPL binds LBP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44789", "l": "2-demethylmenaquinol-11 + S-adenosyl-L-methionine => H(+) + menaquinol-11 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30375", "l": "(2E,6E)-farnesyl diphosphate = (+)-thujopsene + diphosphate"}, {"i": "EC:4.2.3.79", "l": "\"Thujopsene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-438026", "l": "Activation and dimerization of c-JUN in the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11993", "l": "L-pipecolate + O2 => H(+) + H2O2 + L-1-piperideine-6-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34828", "l": "H(+) + N-acyl-15-methylhexadecasphinganine + NADPH + O2 => H2O + N-acyl-4-hydroxy-15-methylhexadecasphinganine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018723", "l": "3-phenanthrol sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60893", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O => a 5'-end phospho-ribonucleoside in snoRNA + H(+) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21209", "l": "H2O + O-phospho-L-serine => L-serine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392752", "l": "Phosphorylation of L1 by CK-II (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11839", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-beta-lactosamine <=> CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53855", "l": "glycocholate + NAD(+) <=> 7-oxo-glycodeoxycholate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45301", "l": "an N-(acyl)-sphingosylphosphocholine + H2O => an N-acyl-sphingoid base + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166542", "l": "beta-NGF dimer binds to TrkA receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098613", "l": "methaneselenol methyltransferase activity"}, {"i": "REACT:R-HSA-2408541", "l": "MeSeH is methylated to Me2Se by MeSeH methyltransferase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085318", "l": "SUMOylation of NCOA2 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33691", "l": "2-(1-hydroxyethyl)thiamine diphosphate + 2-oxobutanoate = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + thiamine diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0031871", "l": "proteinase activated receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44192", "l": "2-methylhexadecanoate + ATP + CoA = 2-methylhexadecanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46644", "l": "cortisol + H(+) + NADPH = 5beta-dihydrocortisol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55183", "l": "2-oxoglutarate + 3-methylnonanoyl-CoA + O2 <=> 2-hydroxy-3-methylnonanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706364", "l": "Internalization of ubiquitinated FLT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193964", "l": "CYP21A2 21-hydroxylates PROG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11613", "l": "H2O + L-glutamate + NADP(+) => 2-oxoglutarate + H(+) + NADPH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010341", "l": "gibberellin carboxyl-O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015056", "l": "corticotrophin-releasing factor receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679028", "l": "JAK3 binds JAK3 inhibitors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1362416", "l": "Frataxin binds iron (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218814", "l": "PAK2 autophorylates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56454", "l": "12-epi-hapalindole U => 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30369", "l": "adenosylcob(III)alamin + phosphate => adenosylcob(III)alamin 5'-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199456", "l": "PTEN dephosphorylates PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3785768", "l": "MRN complex binds DNA double strand breaks (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044687", "l": "geranylfarnesyl diphosphate synthase activity"}, {"i": "MetaCyc:RXN-8813"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34283", "l": "2 L-tyrosine + O2 = 2 L-dopa"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65480", "l": "2-methylbutanoyl-CoA + hexan-1-ol = CoA + hexyl 2-methylbutanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018625", "l": "naphthalene 1,2-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551648", "l": "SUMOylation of TDG with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016040", "l": "glutamate synthase (NADH) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56634", "l": "1,8-cineole + diphosphate => H2O + neryl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76031", "l": "2 H2O2 => O2 + 2 H2O (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451366", "l": "Activation of p38MAPK by DSCAM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20072", "l": "(Z)-phenylacetaldehyde oxime <=> H2O + phenylacetonitrile"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5444516", "l": "Formation of MSH2:MSH6 Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33852", "l": "GDP-alpha-D-mannose + N-tetracosanoylsphinganine-(1D-myo-inositol) => GDP + H(+) + mannosyl-alpha-1->6-inositol phospho-N-tetracosanoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849906", "l": "SALM1 binds NMDA receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9628756", "l": "NEIL1 G83D does not cleave FapyA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35672", "l": "(S)-5'-oxoaverantin + H(+) => (1'S,5'S)-averufin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44600", "l": "a fatty acid + ATP + H(+) = a fatty acyl-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43658", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CDP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40126", "l": "an omega-hydroxy fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-oxo fatty acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801762", "l": "REG3A oligomerize to form a pore complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20044", "l": "3-oxopropanoate + H2O + NADP(+) <=> 2 H(+) + malonate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36250", "l": "S-adenosyl-L-methionine + trans-anol <=> H(+) + S-adenosyl-L-homocysteine + trans-anethole"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50663", "l": "3-(3-methylsulfanyl)propylmalate <=> 2-(2-methylsulfanyl)propylmaleate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17029", "l": "(S)-allantoin + H2O = allantoate + H(+)"}, {"i": "EC:3.5.2.5", "l": "\"Allantoinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693575", "l": "DNA-PKcs autophosphorylates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139920", "l": "Translocation of tBID to mitochondria (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49634", "l": "(3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + diphosphate + H(+) => (2E,6E)-farnesyl diphosphate + 3,5-dimethylorsellinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28701", "l": "Mn(2+)(out) => Mn(2+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453338", "l": "PGYM b dimer:AMP complex <=> PGYM dimer, b form + 2 AMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28527", "l": "(R)-carnitine + crotonobetainyl-CoA => (R)-carnitinyl-CoA + crotonobetaine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43994", "l": "16-hydroxy-(2E,6E,10E)-geranylgeraniol + H2O + NADP(+) => (2E,6E,10E)-geranylgeraniol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45455", "l": "H2O + N-tetradecanoylethanolamine <=> ethanolamine + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47660", "l": "acetyl-CoA + L-methionine sulfoximine = CoA + H(+) + N-acetyl-L-methionine sulfoximine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20925", "l": "a [peptide]-C-terminal (2S)-2-hydroxyglycine => a [peptide]-C-terminal amide + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62493", "l": "ATP + holo-[peptidyl-carrier protein] + L-arginine => AMP + diphosphate + L-arginyl-[peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1370500", "l": "PRLR binds SCF beta-TrCP complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11148", "l": "4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O"}, {"i": "EC:1.16.3.1", "l": "\"Ferroxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54651", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate <=> (2E,6E,10E)-geranylgeranyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24605", "l": "7-methylxanthine + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + theobromine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070636", "l": "nicotinic acid riboside hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032035", "l": "myosin II tail binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450348", "l": "Activated human JNKs migrate to nucleoplasm (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30030", "l": "D-glyceraldehyde + H(+) + NADH <=> glycerol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62398", "l": "(S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH => (1S,2S)-pseudoephedrine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20677", "l": "alizarin + UDP-alpha-D-glucose = 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP"}, {"i": "EC:2.4.1.103", "l": "\"Alizarin 2-beta-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140320", "l": "PAMP receptor decoy activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.45", "l": "\"UDP-sugar diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65627", "l": "hexadecanoyl-CoA + sphinga-(4E,8Z)-dienine <=> CoA + H(+) + N-hexadecanoylsphinga-(4E,8Z)-dienine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55485", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047875", "l": "ecdysone oxidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120053", "l": "ribitol beta-1,4-xylosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050391", "l": "valine dehydrogenase (NADP) activity"}, {"i": "MetaCyc:VALINE-DEHYDROGENASE-NADP+-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29290", "l": "2 H(+)(in) + L-aspartate(in) <=> 2 H(+)(out) + L-aspartate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64649", "l": "(E)-coniferaldehyde + CoA + NADP(+) => (E)-feruloyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042279", "l": "nitrite reductase (cytochrome, ammonia-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54575", "l": "a uridine in tRNA <=> a pseudouridine in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10184", "l": "(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O = 3-oxoadipate + H(+)"}, {"i": "EC:3.1.1.24", "l": "\"3-oxoadipate enol-lactonase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59249", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + (E)-4-coumaroyl-CoA => (E)-4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43527", "l": "L-allo-threonine + NADP(+) <=> aminoacetone + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16538", "l": "(9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O => (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848124", "l": "PTK6 phosphorylates STAT3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43165", "l": "7-cyano-7-deazaguanine + guanosine(15) in tRNA => 7-cyano-7-carbaguanosine(15) in tRNA + guanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41924", "l": "(3R)-hydroxyoctadecanoyl-[ACP] = (2E)-octadecenoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55049", "l": "(3E,5Z)-dodecadienoyl-CoA + H2O => (3E,5Z)-dodecadienoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33947", "l": "2-deoxystreptamine + UDP-N-acetyl-alpha-D-glucosamine = 2'-N-acetylparomamine + H(+) + UDP"}, {"i": "EC:2.4.1.283", "l": "\"2-deoxystreptamine N-acetyl-D-glucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209181", "l": "ARM displaces GRO and binds to PAN which activates transcription (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001858", "l": "complement component iC3b receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24901", "l": "2 GTP <=> cyclic di-3',5'-guanylate + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61249", "l": "H2O + L-tyrosine + O2 => 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35825", "l": "7,8-dihydromethanopterin + H(+) + NADH => 5,6,7,8-tetrahydromethanopterin + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.2.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64571", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one <=> ilicicolin H"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004137", "l": "deoxycytidine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5226999", "l": "ADD1:ADD3 binds DMTN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59010", "l": "H(+) + H2O2 + salicylate => H2O + O2 + salicylaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65033", "l": "3 a quinone + protoporphyrinogen IX => 3 a quinol + protoporphyrin IX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37666", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29743", "l": "2-phenylethylamine(in) = 2-phenylethylamine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46745", "l": "ATP + hydrogencarbonate => ADP + carboxyphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46996", "l": "6-hydroxy-N-methylmyosmine + H2O = 6-hydroxypseudooxynicotine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31213", "l": "diphosphate + L-adenosylselenomethionine + phosphate => ATP + H2O + L-selenomethionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25374", "l": "(2S)-2-amino-4-deoxychorismate + FMN <=> 3-(1-carboxyvinyloxy)anthranilate + FMNH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23155", "l": "a ubiquinone + H(+) + NADH <=> a ubiquinol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61899", "l": "betaenone C <=> betaenone A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670874", "l": "FIXa variant:FVIIIa does not convert FX to the active FXa (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432897", "l": "ILK interacts with beta-1 integrin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868236", "l": "BAR domain proteins recruit dynamin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709406", "l": "CO binds to Cytochrome c oxidase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49445", "l": "(2-aminobenzoyl)acetyl-CoA + H2O => (2-aminobenzoyl)acetate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030170", "l": "pyridoxal phosphate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112042", "l": "Opioid binds MOR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014456", "l": "GDIs block activation of RHOG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013158", "l": "CDC42 GDIs block activation of CDC42 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19391", "l": "(E)-feruloyl-CoA + ADP + phosphate => (E)-ferulate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13794", "l": "2-methyleneglutarate => 2-methylene-3-methylsuccinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17599", "l": "2 [Fe(II)cytochrome c] + D-fructose + 2 H(+) => 2 [Fe(III)cytochrome c] + D-mannitol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001918", "l": "farnesylated protein binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047170", "l": "glucarate O-hydroxycinnamoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018506", "l": "maleylacetate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3266557", "l": "Factor I cleaves iC3b (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2574845", "l": "AJUBA binds centrosome-associated AURKA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972952", "l": "POU5F1 (OCT4), NANOG bind the GATA6 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21370", "l": "5-hydroxyisourate + H2O2 => H2O + O2 + urate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29801", "l": "ADP + D-allose(in) + H(+) + phosphate => ATP + D-allose(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874082", "l": "MET phosphorylates PTK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682388", "l": "Autophagosome maturation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085027", "l": "Defective GFPT1 does not transfer an amino group from L-Gln to F6P to form GlcN6P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27274", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39951", "l": "(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211239", "l": "Association of DFF40 with chromatin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418925", "l": "ADORA2A,B bind Ade-Rib (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2464810", "l": "atRAL(membrane) diffuses to atRAL(cytosol) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61086", "l": "(2R,3R)-dihydrokaempferol + CO2 + succinate => (2S)-naringenin + 2-oxoglutarate + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0015928", "l": "fucosidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0015204", "l": "urea transmembrane transporter activity"}, {"i": "REACT:R-HSA-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Homo sapiens)"}, {"i": "RHEA:32799", "l": "urea(in) = urea(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59614", "l": "beta-alanine + L-ornithine => beta-alanyl-L-ornithine + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003871", "l": "5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"}, {"i": "MetaCyc:HOMOCYSMET-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29900", "l": "ATP + D-xylose(out) + H2O => ADP + D-xylose(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9737046", "l": "L-Glutamate binds GRM4 (mGluR4) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161282", "l": "Elastic fibres bind associated proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37323", "l": "glycyl-L-methionine + H2O = glycine + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21782", "l": "AH2 + cyclohex-2-enone => A + cyclohexanone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446077", "l": "BP230 interacts with keretin K5/K14 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48168", "l": "H2O + N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine = N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450488", "l": "BRF1 Complex recruits RNA degradation activities (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391942", "l": "IP receptor can bind prostacyclin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45294", "l": "2-glyceryl-prostaglandin H2 + A + H2O => 2-glyceryl-prostaglandin G2 + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33951", "l": "ribostamycin + UDP-N-acetyl-alpha-D-glucosamine = 2'''-acetyl-6'''-hydroxyneomycin C + H(+) + UDP"}, {"i": "EC:2.4.1.285", "l": "\"UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49049", "l": "25-hydroxyvitamin D2 + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 1alpha,25-dihydroxyvitamin D2 + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34168", "l": "2,6-dihydroxypseudooxynicotine + H2O => 2,6-dihydroxypyridine + 4-(methylamino)butanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40670", "l": "2-aminoprop-2-enoate <=> 2-iminopropanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204434", "l": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35425", "l": "an anthocyanidin 3,5-di-O-beta-D-glucoside + 2 H(+) + UDP => an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20229", "l": "2,3-dihydroxybenzoate + ATP + H(+) = 2,3-dihydroxybenzoyl-5'-AMP + diphosphate"}, {"i": "EC:2.7.7.58", "l": "\"(2,3-dihydroxybenzoyl)adenylate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791138", "l": "Expression of TPP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59275", "l": "L-cysteine <=> D-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50207", "l": "(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 <=> (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59058", "l": "dimethyl disulfide + H(+) + NADH => 2 methanethiol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43792", "l": "adenosine(645) in 25S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(645) in 25S rRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.287", "l": "\"25S rRNA (adenine(645)-N(1))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12987", "l": "GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] => GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62588", "l": "2-hydroxy-2-(4-hydroxyphenyl)acetate + H(+) = 4-hydroxybenzyl alcohol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9005980", "l": "IL21 binds IL21R:JAK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-622310", "l": "Activated NOD1 oligomerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13560", "l": "ATP + glycine + L-gamma-glutamyl-L-cysteine <=> ADP + glutathione + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953111", "l": "E2F6 binds TFDP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50514", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein] => acetyl-CoA + N-terminal L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139919", "l": "Translocation of BIM to mitochondria (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31364", "l": "NADP(+) + reduced coenzyme F420-(gamma-Glu)(n) => 2 H(+) + NADPH + oxidized coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26437", "l": "indole + L-serine <=> H2O + L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52333", "l": "2 N(omega)-hydroxy-L-arginine + 2 O2 + reduced [flavodoxin] => 3 H(+) + 2 H2O + 2 L-citrulline + 2 nitric oxide + oxidized [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019969", "l": "interleukin-10 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10837", "l": "NADPH + O2 + questin => demethylsulochrin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13472", "l": "A + H2O + thymine <=> 5-methylbarbiturate + AH2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42940", "l": "cytidine(34) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665280", "l": "ERBB2 KD mutants do not bind osimertinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647660", "l": "GSDME (1-270) binds PIPs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14630", "l": "ATP + N-acetyl-L-glutamate => ADP + N-acetyl-L-glutamyl 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004097", "l": "catechol oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42582", "l": "AMP + diphosphate + H(+) + L-seryl-tRNA(Sec) => ATP + L-serine + tRNA(Sec)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44715", "l": "a 1,2-diacylglycerol + H2O <=> a 1-acylglycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912467", "l": "BRCA1 is recruited to unsynapsed regions (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30958", "l": "9,9'-di-cis-zeta-carotene + 2 a quinone <=> 7,7',9,9'-tetra-cis-lycopene + 2 a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102043", "l": "isopentenyl phosphate kinase activity"}, {"i": "MetaCyc:RXN-10068"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45726", "l": "(E)-4-coumaraldehyde + H(+) + NADPH => (E)-4-coumaroyl alcohol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2400010", "l": "AKT inhibitors block AKT membrane recruitment (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64183", "l": "an N-(fatty acyl)-L-tryptophan + H2O <=> a fatty acid + L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618725", "l": "SOX10, EGR2 and NAB proteins bind the GJB1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683583", "l": "ATG10:ATG12:ATG7 dimer dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371591", "l": "Trimerization of cytosolic HSF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14628", "l": "[(1->4)-alpha-D-glucosyl](n) + [(1->6)-alpha-D-glucosyl](n+1) <=> [(1->4)-alpha-D-glucosyl](n+1) + [(1->6)-alpha-D-glucosyl](n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37396", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34191", "l": "(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.52", "l": "\"Beta-N-acetylhexosaminidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16565", "l": "2-oxoglutarate + L-histidine = 3-(imidazol-5-yl)pyruvate + L-glutamate"}, {"i": "EC:2.6.1.38", "l": "\"Histidine transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16989", "l": "1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate"}, {"i": "EC:3.1.3.8", "l": "\"3-phytase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46753", "l": "7alpha-hydroxycholest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9626928", "l": "CREBBP binds FOXO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788622", "l": "p-Y-STATs dimerize (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176116", "l": "Recruitment and activation of Chk1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28819", "l": "5-dehydro-D-gluconate(in) + H(+)(in) = 5-dehydro-D-gluconate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867613", "l": "PICALM binds R-SNAREs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45401", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48361", "l": "a 1,2-saturated fatty acid + H2O2 => a 2-hydroxy fatty acid + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928578", "l": "EPH receptors autophosphorylate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63665", "l": "(S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADPH => H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195275", "l": "Phosphorylation of APC component of the destruction complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18509", "l": "H(+) + H2O2 + NADH = 2 H2O + NAD(+)"}, {"i": "EC:1.11.1.1", "l": "\"NADH peroxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64849", "l": "(3Z)-hex-3-en-1-ol + benzoyl-CoA => (3Z)-hex-3-en-1-yl benzoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.213", "l": "\"3-alpha-hydroxysteroid dehydrogenase (Re-specific)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55427", "l": "(3S,6E)-nerolidol + O2 + reduced [NADPH--hemoprotein reductase] <=> (3E)-4,8-dimethylnona-1,3,7-triene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114558", "l": "Thrombin-activated PARs activate Gq (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24284", "l": "L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH"}, {"i": "EC:1.2.1.11", "l": "\"Aspartate-semialdehyde dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50140", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4839746", "l": "Truncated AMER1 mutants destabilize the destruction complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32024", "l": "(2E,6E)-farnesyl diphosphate + H2O => avermitilol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-427514", "l": "eNoSC deacetylates histone H3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34340", "l": "22R-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (20R,22R)-20,22-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114560", "l": "Adhesion of integrin alphaIIbbeta3 to fibrin network (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070038", "l": "rRNA (pseudouridine-N3-)-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41661", "l": "dihydrosanguinarine + NAD(+) => NADH + sanguinarine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626938", "l": "Beta-catenin binds SOX proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3262512", "l": "G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21981", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) => adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018030", "l": "peptidyl-lysine N6-myristoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57178", "l": "N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] => L-arginyl-[protein] + methylglyoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3204318", "l": "cob(II)alamin binds to MTRR:MTR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27485", "l": "allantoate + 2 H(+) + H2O = (S)-2-ureidoglycine + CO2 + NH4(+)"}, {"i": "EC:3.5.3.9", "l": "\"Allantoate deiminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59115", "l": "ATP + L-serine <=> ADP + H(+) + O-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21299", "l": "D-galactose + NAD(+) <=> D-galactono-1,4-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046966", "l": "thyroid hormone receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51524", "l": "(S)-corytuberine + S-adenosyl-L-methionine = magnoflorine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56523", "l": "Fe-coproporphyrin III + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + 2 CO2 + heme b + 2 L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13704", "l": "acetyl-CoA + L-homoserine <=> CoA + O-acetyl-L-homoserine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50246", "l": "3beta-hydroxyandrost-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17alpha-hydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37369", "l": "2,3-bis-O-phytanyl-sn-glycero-3-phospho-L-serine + CMP + H(+) => CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64786", "l": "2-aminoprop-2-enoate + ethanethiol => S-ethyl-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848975", "l": "PTK6 phosphorylates KHDRBS1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5620975", "l": "MLKL binds PIPs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022065", "l": "DSPGs are secreted (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38184", "l": "19-hydroxytestosterone + O2 + reduced [NADPH--hemoprotein reductase] => 19-oxotestosterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52474", "l": "16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17beta-estriol + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64226", "l": "5-hydroxyuridine(34) in tRNA + A + H2O => AH2 + O2 + uridine(34) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.48", "l": "\"Plasminogen activator Pla\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23812", "l": "(+)-neomenthol + NADP(+) = (1R,4S)-menthone + H(+) + NADPH"}, {"i": "EC:1.1.1.208", "l": "\"(+)-neomenthol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64150", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-R + CMP + H(+) => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13314", "l": "H2O + O2 + sarcosine => formaldehyde + glycine + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61585", "l": "cytidine(72) in tRNA(Cys) + S-adenosyl-L-methionine => 5-methylcytidine(72) in tRNA(Cys) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694389", "l": "nsp3 is glycosylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798373", "l": "MDM2 ubiquitinates DYRK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1605736", "l": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41423", "l": "2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2 <=> CO2 + grixazone B + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.12", "l": "\"2-methylacyl-CoA dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851352", "l": "CCR8 binds CCL1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847968", "l": "PTEN binds FRK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66467", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O <=> scalarane-17alpha-19-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14721", "l": "UDP-alpha-D-xylose + zeatin = H(+) + O-beta-D-xylosylzeatin + UDP"}, {"i": "EC:2.4.2.40", "l": "\"Zeatin O-beta-D-xylosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964842", "l": "Shikimate results from hydration of DHS (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855173", "l": "5-PP-IP4 transports from the nucleus to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40215", "l": "FADH2 + O2 = FAD + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111915", "l": "CAMK4 autophosphorylates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0016842", "l": "amidine-lyase activity"}, {"i": "EC:4.3.2.-", "l": "\"Lyases acting on amides, amidines, etc\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322429", "l": "XIAP monoubiquinates TLE (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59389", "l": "a fatty acid ester + H2O => a fatty acid + an aliphatic alcohol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42528", "l": "uridine(955/2504/2580) in 23S rRNA = pseudouridine(955/2504/2580) in 23S rRNA"}, {"i": "EC:5.4.99.24", "l": "\"23S rRNA pseudouridine(955/2504/2580) synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216082", "l": "Interaction of integrin alphaXbeta2 with fibrin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018680", "l": "deethylatrazine monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27937", "l": "(3S)-3-hydroxy-D-aspartate <=> glycine + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25321", "l": "N-methylethanolamine phosphate + S-adenosyl-L-methionine = H(+) + N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.103", "l": "\"Phosphoethanolamine N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17429", "l": "NAD(+) + trans-4-hydroxycyclohexanecarboxylate = 4-oxocyclohexanecarboxylate + H(+) + NADH"}, {"i": "EC:1.1.1.226", "l": "\"4-hydroxycyclohexanecarboxylate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0019840", "l": "isoprenoid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871226", "l": "RET binds GFRA1,GFRA2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047192", "l": "1-alkylglycerophosphocholine O-acetyltransferase activity"}, {"i": "MetaCyc:2.3.1.67-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9650473", "l": "SERPING1 is secreted (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5688294", "l": "SIRT5 deacetylates Cytochrome C (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196026", "l": "Dab2 is recruited to the junctional plaques (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54930", "l": "(3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] + NADP(+) => 3-oxo-(9Z)-hexadecenoyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52391", "l": "ATP + D-threonate <=> 4-O-phospho-D-threonate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18075", "l": "AH2 + orotate => (S)-dihydroorotate + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809680", "l": "MTMR12 binds MTM1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40293", "l": "AMP + diphosphate + tetradecanedioyl-CoA => ATP + CoA + tetradecanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65210", "l": "(S)-3-hydroxybutanoate + CoA + H(+) => (3S)-3-hydroxybutanoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-996727", "l": "REST recruits the BHC complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31570", "l": "bisphenol A + H(+) + NADH + O2 <=> 2,2-bis(4-hydroxyphenyl)-1-propanol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32717", "l": "2-oxobutanoate + CO2 + NADH => (2R,3S)-3-methylmalate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72139", "l": "Formation of the active Spliceosomal C (B*) complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050303", "l": "lysine 6-dehydrogenase activity"}, {"i": "MetaCyc:LYSINE-6-DEHYDROGENASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36902", "l": "guanosine(37) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63223", "l": "7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + archaeosine(15) in tRNA + 2 H(+) + L-1-piperideine-6-carboxylate + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52911", "l": "3-dimethylallyl-4-hydroxyphenylpyruvate + O2 <=> 3-dimethylallyl-4-hydroxymandelate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41706", "l": "1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804741", "l": "MDM2 forms homo- or heterodimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47723", "l": "H(+) + H2O + isoguanine <=> NH4(+) + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174786", "l": "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55247", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5629237", "l": "HENMT1 methylates 2' hydroxyl at 3' end of piRNA in MeR-PIWIL4:piRNA:TDRD9:MAEL:TDRKH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "55.755410487716034", "identifiers": [{"i": "GO:0016616", "l": "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51791", "l": "2-hydroxybenzoyl-5'-AMP + CoA <=> 2-hydroxybenzoyl-CoA + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42984", "l": "(+)-copalyl diphosphate = diphosphate + pimara-8(14),15-diene"}, {"i": "EC:4.2.3.147", "l": "\"Pimaradiene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36714", "l": "ATP + H(+) + H2O + O-ureido-D-serine <=> ADP + CO2 + D-cycloserine + NH4(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49425", "l": "ATP + validone => ADP + H(+) + validone 7-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362386", "l": "Glycosylation of Hh (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10332", "l": "a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA"}, {"i": "EC:2.3.1.62", "l": "\"2-acylglycerophosphocholine O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22808", "l": "6-hydroxynicotinate + H2O + O2 = 2,6-dihydroxynicotinate + H2O2"}, {"i": "EC:1.17.3.3", "l": "\"6-hydroxynicotinate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9690461", "l": "FKBP1A binds tacrolimus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990080", "l": "2-phenylethylamine receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54546", "l": "1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine => 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37955", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55167", "l": "a jasmonyl-L-isoleucinate + H(+) + NADPH + O2 <=> H2O + L-isoleucine-12-hydroxyjasmonate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12433", "l": "L-alanyl-tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine => H(+) + tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-N(6)-(L-alanyl)-L-lysyl-D-alanyl-D-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35166", "l": "H(+)(out) + minocycline(in) <=> H(+)(in) + minocycline(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37138", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate <=> 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032795", "l": "heterotrimeric G-protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59298", "l": "an N-acyl-(2S)-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical => an N-acylglycine + 2 L-ascorbate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32140", "l": "ATP + CoA + malonate => AMP + diphosphate + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13809", "l": "aspulvinone E + 2 dimethylallyl diphosphate = aspulvinone H + 2 diphosphate"}, {"i": "EC:2.5.1.35", "l": "\"Aspulvinone dimethylallyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2467811", "l": "Separation of sister chromatids (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23738", "l": "5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) => 5-hydroxyisourate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17115", "l": "H(+) + L-serine + phosphoethanolamine => H2O + L-serine-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-976801", "l": "Complement factor I complex formation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16015", "l": "AMP + diphosphate + glycyl-tRNA(Gly) => ATP + glycine + tRNA(Gly)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-176318", "l": "Loading of claspin onto DNA during replication origin firing (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31661", "l": "5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine => beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GlcpNAc + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43154", "l": "H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine => adenosine(58) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29435", "l": "enterobactin(in) + H(+)(out) = enterobactin(out) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-976801", "l": "Complement factor I complex formation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46844", "l": "4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 = 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9710254", "l": "GSDME oligomerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46246", "l": "(14E)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => 2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034557", "l": "2-hydroxylaminobenzoate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592232", "l": "Expression of TFB1M (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032942", "l": "inositol tetrakisphosphate 2-kinase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0047617", "l": "acyl-CoA hydrolase activity"}, {"i": "RHEA:16781", "l": "a fatty acyl-CoA + H2O = a fatty acid + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-213406", "l": "Disassociation of PLC-gamma1 from LAT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389381", "l": "Gads binds CD28 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336413", "l": "DT:HBEGF:CD9 is transported from clathrin-coated vesicle to endosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982017", "l": "Active G alpha (q) binds RGS proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112430", "l": "Formation of P-TEFb complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975100", "l": "Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604712", "l": "Initial activation of proMMP7 by trypsin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57210", "l": "S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] => glyoxal + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944223", "l": "Association of procollagen type V (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13023", "l": "3,4-dihydroxybenzoate + formaldehyde + H2O + NAD(+) => 4-hydroxy-3-methoxybenzoate + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4839734", "l": "AXIN mutants destabilize the destruction complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047891", "l": "flavone 7-O-beta-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41388", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693561", "l": "RAD51 binds BRCA2 at resected DNA DSBs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445072", "l": "Interaction of PAK1 with Rac1-GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-380586", "l": "loading of Serotonin in synaptic vesicles (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800298", "l": "HGF dimer binds MET (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74740", "l": "Binding of SHC1 to insulin receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917839", "l": "apo-Transferrin dissociates from the receptor complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69074", "l": "Formation of Processive Complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349426", "l": "Phosphorylation of MDM4 by CHEK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60470", "l": "3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) => 3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17911", "l": "acetaldehyde + formate => (S)-lactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450550", "l": "PKCalpha phosphorylates HuR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635854", "l": "GLI2,3 are degraded by the proteasome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60288", "l": "N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.366", "l": "\"[Histone H3]-N(6),N(6)-dimethyl-lysine(9) N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3149519", "l": "MMACHC decyanates CNCbl (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43262", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682377", "l": "LC3 de-lipidation by ATG4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23162", "l": "L-rhamnulose => L-rhamnopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66191", "l": "3',5'-cyclic GMP(in) + ATP + H2O <=> 3',5'-cyclic GMP(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54719", "l": "N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42918", "l": "2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine => adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18114", "l": "a ribonucleoside 5'-diphosphate + ATP => a ribonucleoside 5'-triphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061599", "l": "molybdopterin molybdotransferase activity"}, {"i": "RHEA:35047", "l": "adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin"}, {"i": "EC:2.10.1.1", "l": "\"Molybdopterin molybdotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429730", "l": "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38070", "l": "2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA <=> 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-877361", "l": "Pyrin binds ASC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668597", "l": "DNA polymerase:primase binds G-strand of the telomere (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "68.973118714897424", "identifiers": [{"i": "GO:0008146", "l": "sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029460", "l": "PAK1 phosphorylates LIMK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10954", "l": "(E)-sinapoyltartronate + CoA => (E)-sinapoyl-CoA + hydroxymalonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21603", "l": "anthranilate + benzoyl-CoA <=> CoA + N-benzoylanthranilate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33678", "l": "H2O + N-(2,3-dihydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+) <=> H(+) + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.11", "l": "\"Gamma-D-glutamyl-meso-diaminopimelate peptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65646", "l": "CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8E)-enine => (4R)-hydroxysphing-(8E)-enine + tetracosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187575", "l": "Ubiquitination of phospho-p27/p21 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28844", "l": "choline(in) + H(+)(in) => choline(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46058", "l": "(11E,13Z)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (11E)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655295", "l": "Activated FGFR3 mutants:p-FRS2 binds GRB2-SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59878", "l": "(indol-3-yl)butanoyl-L-cysteine + AMP + diphosphate + H(+) => (indol-3-yl)butanoate + ATP + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876484", "l": "NPC2 transfers CHOL to NPC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48057", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O => beta-D-glucosylceramide + D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22932", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}, {"i": "EC:2.4.1.38", "l": "\"Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51467", "l": "deoxycholate + O2 + reduced [NADPH--hemoprotein reductase] <=> 1beta-hydroxydeoxycholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57638", "l": "holo-[2-methylbutanoate polyketide synthase] + mevinic carboxylate => (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + ML-236A carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612980", "l": "BRAF in Rap1-GTP complex:BRAF complex autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62557", "l": "3,4-dihydroxyphenylacetate + H(+) => 4-methylcatechol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49312", "l": "2-trans,4-trans-xanthoxin + NAD(+) = 2-trans-(+)-abscisic aldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213208", "l": "Type X collagen associates with collagen type II fibrils (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46903", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) <=> a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) (E. coli)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.42", "l": "\"[Glycogen-synthase-D] phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27531", "l": "(2E,6E)-farnesyl diphosphate + H2O => (3S,6E)-nerolidol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15911", "l": "aminoacetaldehyde + CO2 + H(+) + succinate + sulfite => 2-oxoglutarate + O2 + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390593", "l": "ATP Hydrolysis By Myosin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10934", "l": "2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+) => ATP + L-aspartate + L-citrulline"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003991", "l": "acetylglutamate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33715", "l": "4-hydroxyeicosasphinganine 1-phosphate = 2-hydroxyoctadecanal + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381283", "l": "Expression of PPARG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19076", "l": "ATP + L-seryl-[I-kappa-B protein] <=> ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023840", "l": "HATs and coactivators are recruited to the CTSD gene (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8856189", "l": "TNFSF8 binds TNFRSF8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22721", "l": "ATP + L-histidyl-[protein] => ADP + H(+) + N(pros)-phospho-L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685604", "l": "SLAMF6 binds SLAMF6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0016785", "l": "selenotransferase activity"}, {"i": "EC:2.9.1.-", "l": "\"Selenotransferases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57941", "l": "Fe-coproporphyrin III + H(+) + H2O2 => CO2 + 2 H2O + harderoheme III"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51392", "l": "(9Z)-octadecenoyl-CoA + serotonin = CoA + H(+) + N-(9Z-octadecenoyl)-serotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622980", "l": "FOXO1 binds NPY gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035489", "l": "guanine/guanine mispair binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170674", "l": "Dissociation of the Gi alpha:G olf complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46218", "l": "3beta-hydroxypregn-4-ene-20-one + NADP(+) => H(+) + NADPH + progesterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39604", "l": "(3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA => (2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26302", "l": "5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) => (S)-allantoin + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694370", "l": "mRNA9a is translated to Nucleoprotein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63790", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610732", "l": "GSK3 phosphorylates p-GLI3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20066", "l": "2'-deoxymugineate + 2-oxoglutarate + O2 => 3-epihydroxy-2'-deoxymugineate + CO2 + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55959", "l": "(9Z)-octadecenoate + AH2 + O2 <=> (12R)-hydroxy-(9Z)-octadecenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54562", "l": "a 5'-triphospho-guanosine-ribonucleotide-tRNA(His) + AMP + H(+) => an adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.12", "l": "\"Met-Xaa dipeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8858428", "l": "FCAMR binds IgA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15344", "l": "ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide <=> ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204824", "l": "Interaction of Tie2 and Ang4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33630", "l": "ATP + CoA + decanoate <=> AMP + decanoyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44230", "l": "9-decenoyl-CoA + AMP + diphosphate => 9-decenoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033863", "l": "ribose 1,5-bisphosphate phosphokinase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047688", "l": "aspartate 4-decarboxylase activity"}, {"i": "RHEA:12621", "l": "H(+) + L-aspartate = CO2 + L-alanine"}, {"i": "EC:4.1.1.12", "l": "\"Aspartate 4-decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36229", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25670", "l": "sucrose + UDP-alpha-D-galactose = H(+) + loliose + UDP"}, {"i": "EC:2.4.1.n2", "l": "\"Loliose synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66812", "l": "5-aminopentanoate + acetyl-CoA + 20 H(+) + 8 malonyl-CoA + 13 NADPH = 8 CO2 + 9 CoA + 7 H2O + 13 NADP(+) + wortmanamide B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62476", "l": "3,4-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] = 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50112", "l": "octadecanoyl-CoA + taurine = CoA + H(+) + N-octadecanoyl-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.-", "l": "\"Dipeptidyl-peptidases and tripeptidyl-peptidases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56290", "l": "H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase] => albendazole + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013145", "l": "RAC1 binds effectors at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951727", "l": "cAMP binds PKA tetramer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31218", "l": "(5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+) <=> (5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790944", "l": "NOP2 (NSUN1) methylates cytidine-4447 of 28S rRNA yielding 5-methylcytidine-4447 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54151", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene <=> 1-hydroxy-all-trans-1,2-dihydro-neurosporene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850945", "l": "Casein kinase II phosphorylates PTEN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396399", "l": "Fibrillins bind BMPs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36697", "l": "desmethyldescarbamoylnovobiocin + dTDP + H(+) => dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62851", "l": "GDP-beta-L-fucose + methyl 8-{[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13581", "l": "N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP"}, {"i": "EC:2.7.8.17", "l": "\"UDP-N-acetylglucosamine--lysosomal-enzyme N-acetylglucosaminephosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848250", "l": "ACBD6 binds LCFA-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237129", "l": "Acireductone is created (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51461", "l": "H2O + N-(9Z-octadecenoyl)-L-glutamate => (9Z)-octadecenoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912790", "l": "CBL binds CRK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26108", "l": "homocitrate <=> cis-homoaconitate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45048", "l": "acetamide + H2O = acetate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52314", "l": "11-dehydro-thromboxane B2 + H(+) + NADH => NAD(+) + thromboxane B2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665998", "l": "MKL1 binds SRF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10663", "l": "L-seryl-[protein] <=> D-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050267", "l": "rubber cis-polyprenylcistransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483174", "l": "PE is methylated to PC by PEMT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928624", "l": "EPHBs bind EFNBs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170159", "l": "Translocation of Cdc25 to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062188", "l": "anandamide 11,12 epoxidase activity"}, {"i": "RHEA:53144", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39094", "l": "(2E)-decenedioyl-CoA + H2O <=> (3S)-hydroxydecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18602", "l": "3,4-dihydroxyphthalate + H(+) => 3,4-dihydroxybenzoate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5695964", "l": "ABHD14B hydrolyses PNPB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3341277", "l": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942052", "l": "Superoxide and nitric oxide react to peroxynitrite in the phagosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952996", "l": "E2F7 forms homodimers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15754", "l": "GTP + IMP + L-aspartate => GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602484", "l": "Activation of proMMP11 by FURIN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19264", "l": "ATP + H2O + heme b(in) <=> ADP + H(+) + heme b(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679145", "l": "Defective ABCG5 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0004596", "l": "peptide alpha-N-acetyltransferase activity"}, {"i": "REACT:R-HSA-6814090", "l": "NatC acetylates ARFFRP1 (Homo sapiens)"}, {"i": "MetaCyc:PEPTIDE-ALPHA-N-ACETYLTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804276", "l": "ATM phosphorylates TTC5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63745", "l": "UDP-alpha-D-glucuronate + zolasartan => UDP + zolarsartan-1-N-beta-D-glucuronide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43133", "l": "N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-methionine => H(+) + N(2)-dimethylguanosine(10) in tRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36705", "l": "(3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+) => (2S,5S)-5-carboxymethylproline + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205321", "l": "Interaction of KIT and sSCF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54197", "l": "N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47028", "l": "[DsrC protein]-S-sulfo-L-cysteine/L-cysteine = [DsrC protein]-disulfide + H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46198", "l": "7alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + pregnenolone + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58303", "l": "25-substituted-cholesterol + beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine <=> 25-substituted-cholesteryl beta-D-glucoside + N-octadecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11204", "l": "apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin = AMP + diphosphate + H(+) + holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]"}, {"i": "EC:6.3.4.10", "l": "\"Biotin--[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008829", "l": "dCTP deaminase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052640", "l": "salicylic acid glucosyltransferase (glucoside-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12945", "l": "2'-hydroxybiphenyl-2-sulfinate + H2O = biphenyl-2-ol + H(+) + sulfite"}, {"i": "EC:3.13.1.3", "l": "\"2'-hydroxybiphenyl-2-sulfinate desulfinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112037", "l": "Inactivation of PLC beta (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33079", "l": "6-amino-6-deoxyfutalosine + H2O = adenine + dehypoxanthine futalosine"}, {"i": "EC:3.2.2.30", "l": "\"Aminodeoxyfutalosine nucleosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9733973", "l": "Bile salts bind FABP6 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60302", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59638", "l": "D-xylotriono-1,5-lactone + H2O2 => D-xylotriose + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55850", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N,7-O-diacetyl-alpha-D-neuraminosyl](n) + n CoA => [(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54768", "l": "[LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine = [LarE protein]-dehydroalanine + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43509", "l": "2,5-diformylfuran + H2O => 2-(dihydroxymethyl)-5-formylfuran"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62637", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide => (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50725", "l": "(E)-4-hydroxyphenylacetaldehyde oxime => (Z)-(4-hydroxyphenyl)acetaldehyde oxime"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27836", "l": "a menaquinol + fumarate => a menaquinone + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46382", "l": "(24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7alpha-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10762", "l": "acetate + oxaloacetate => citrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63812", "l": "ATP + N(8)-citryl-spermidine + spermidine = AMP + diphosphate + H(+) + N(8),N'(8)-citryl-bis(spermidine)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19290", "l": "H2O + sucrose 6(F)-phosphate => phosphate + sucrose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396007", "l": "IRF3 is phosphorylated by TBK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24164", "l": "[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]"}, {"i": "EC:1.8.4.12", "l": "\"Peptide-methionine (R)-S-oxide reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442387", "l": "ZIP8 mediates zinc influx into cells (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.60", "l": "\"Caspase-7\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090430", "l": "caffeoyl-CoA: alcohol caffeoyl transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4093342", "l": "SDC2 multimerises (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32045", "l": "2 ATP + 2 H(+) => H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64127", "l": "H2O + N-hexadecanoyl-L-phenylalanine <=> hexadecanoate + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110215", "l": "Cleavage of uracil by UNG glycosylase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848339", "l": "PNPLA5 hydrolyzes TAG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15961", "l": "4-hydroxymandelonitrile + UDP-alpha-D-glucose = H(+) + taxiphyllin + UDP"}, {"i": "EC:2.4.1.178", "l": "\"Hydroxymandelonitrile glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66666", "l": "ADP + coproporphyrin III(out) + H(+) + phosphate => ATP + coproporphyrin III(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32364", "l": "L-gulono-1,4-lactone + O2 => H(+) + H2O2 + L-ascorbate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038046", "l": "G protein-coupled enkephalin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626982", "l": "TNF-alpha:TNFR1:NSMAF binds GNB2L1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2426566", "l": "Interaction of DAP12 and CLM7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015452", "l": "methyl transfer-driven active transmembrane transporter activity"}, {"i": "TCDB:3.C"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102947", "l": "(+)-delta-cadinene-8-hydroxylase activity"}, {"i": "MetaCyc:RXN-9045"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25593", "l": "2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2"}, {"i": "EC:2.2.1.9", "l": "\"2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46543", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "58.788064655352613", "identifiers": [{"i": "GO:0016810", "l": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004637", "l": "phosphoribosylamine-glycine ligase activity"}, {"i": "MetaCyc:GLYRIBONUCSYN-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13490", "l": "(S)-canadine + H(+) + 2 O2 => berberine + 2 H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483186", "l": "PC is converted to PS by PTDSS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45843", "l": "(3R)-3-hydroxydecanoyl-CoA + NADP(+) <=> 3-oxodecanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650165", "l": "ASIC trimers bind H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40786", "l": "docosanoyl-CoA + H2O <=> CoA + docosanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57658", "l": "CMP + ganglioside GT1balpha + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1b"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.359", "l": "\"Aldose 1-dehydrogenase (NAD(P)(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42220", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate = 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64892", "l": "holo-[ACP] + tetradecanoyl-AMP = AMP + H(+) + tetradecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25598", "l": "5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate => (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798299", "l": "TP53 stimulates E2F7 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47652", "l": "D-ribitol 1-phosphate + H2O = phosphate + ribitol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.3", "l": "\"2-acetolactate mutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229194", "l": "Depolymerization of lamin filaments after PKC-mediated phosphorylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61509", "l": "peonidin + UDP-alpha-D-glucose => peonidin 3-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15762", "l": "L-homoserine + NADP(+) => H(+) + L-aspartate 4-semialdehyde + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34345", "l": "4-methylpentanal + 2 H2O + 2 oxidized [adrenodoxin] + pregnenolone => (20R,22R)-20,22-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028525", "l": "NR1H2 or NR1H3, NRIP1 bind the SREBF1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11322", "l": "UDP-alpha-D-xylose => UDP-beta-L-arabinopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209240", "l": "Activated phosphorylated TAK1 kinase phosphorylates and activates IRD5 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000263", "l": "TCII:Cbl is degraded to release Cbl (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140769", "l": "factor VII -> factor VIIa (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36287", "l": "H(+) + NADPH + O2 + theobromine = 7-methylxanthine + formaldehyde + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357445", "l": "PAK1-3 dimer disassociates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29864", "l": "AMP + GTP => ADP + GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0032576", "l": "O-linoleoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24641", "l": "ergosteryl 3-beta-D-glucoside + H2O => D-glucose + ergosterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31350", "l": "(+)-abscisic acid D-glucopyranosyl ester + H2O <=> 2-cis-(+)-abscisate + beta-D-glucose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216048", "l": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64132", "l": "H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-L-phenylalanine = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64481", "l": "4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate => (1S,3R,6R,8R,9R,11R,14S,15S,19R,20R)-8-ethyl-9,15-dihydroxy-3,4,6,20-tetramethyl-21,23-dioxo-24-azapentacyclo[20.2.1.0(1,6).0(11,20).0(14,19)]pentacosa-4,12,22(25)-trien-25-olate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15242", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-yl acetate => 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014296", "l": "RAC2 GEFs activate RAC2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12322", "l": "1,2-dihydrovomilenine + 2 H(+) + NADPH => 17-O-acetylnorajmaline + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24070", "l": "H2O + hexano-6-lactone + NADP(+) => cyclohexanone + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42928", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.199", "l": "\"16S rRNA (cytosine(1402)-N(4))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2129375", "l": "Elastin cross-linking by lysyl oxidase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "81.790986234327661", "identifiers": [{"i": "GO:0004645", "l": "1,4-alpha-oligoglucan phosphorylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31380", "l": "H2O + pyrrole-2-carboxylate => 1H-pyrrole + hydrogencarbonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.29", "l": "\"Aureolysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201669", "l": "Beta-catenin translocates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690702", "l": "LYN phosphorylates CD22 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48425", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H2O => (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dUMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31306", "l": "a reduced flavin + NAD(+) <=> an oxidized flavin + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163320", "l": "Association of mTERF with the termination sequence (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63698", "l": "H(+) + SN-38 O-beta-D-glucuronide + UDP => SN-38 + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0008409", "l": "5'-3' exonuclease activity"}, {"i": "REACT:R-HSA-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Homo sapiens)"}, {"i": "REACT:R-HSA-5358619", "l": "EXO1 interacting with MSH2:MSH3 excises DNA strand containing an insertion/deletion loop (IDL) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031716", "l": "calcitonin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37319", "l": "ATP + glycyl-L-methionine(out) + H2O = ADP + glycyl-L-methionine(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22657", "l": "CDP-ethanolamine + L-serine => CMP + H(+) + L-serine-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61100", "l": "(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-dihydrotricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61827", "l": "pregnenolone + UDP-alpha-D-glucose <=> H(+) + pregnenolone 3-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050050", "l": "leucine N-acetyltransferase activity"}, {"i": "RHEA:20089", "l": "acetyl-CoA + L-leucine = CoA + H(+) + N-acetyl-L-leucine"}, {"i": "EC:2.3.1.66", "l": "\"Leucine N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31947", "l": "ent-isokaurene + O2 + reduced [NADPH--hemoprotein reductase] = ent-isokauren-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769397", "l": "SOST binds LRP5/6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9656244", "l": "DRD2 binds DA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30068", "l": "betaine aldehyde + H2O + NADP(+) => glycine betaine + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202111", "l": "AKT1 phosphorylates eNOS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684008", "l": "NBN binds KPNA2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-481007", "l": "Exocytosis of platelet alpha granule contents (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036348", "l": "hydantoin racemase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050284", "l": "sinapate 1-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0016815", "l": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles"}, {"i": "EC:3.5.5.-", "l": "\"In nitriles\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392748", "l": "L1 binds to AP-2 Clathrin complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10627", "l": "2 ATP + CO2 + H2O + NH4(+) <=> 2 ADP + carbamoyl phosphate + 3 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11157", "l": "H2O + L-valine + NADP(+) => 3-methyl-2-oxobutanoate + H(+) + NADPH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.13.1", "l": "\"Exoribonuclease II\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58050", "l": "2-O-sulfo-2'-O-octadecanoyl-alpha,alpha-trehalose + CoA => 2-O-sulfo-alpha,alpha-trehalose + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851908", "l": "Activated MET binds GAB1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.12", "l": "\"N-acetylgalactosamine-4-sulfatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001164", "l": "RNA polymerase I core promoter sequence-specific DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46966", "l": "2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate => lactate + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10938", "l": "6-decylubiquinol + tetrathionate => 6-decylubiquinone + 2 thiosulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450088", "l": "GLUT1 tetramer binds 4xATP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14443", "l": "CoA + H(+) + N(3)-acetylgentamycin C => acetyl-CoA + gentamicin C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33950", "l": "2-deoxystreptamine + UDP-N-acetyl-alpha-D-glucosamine <=> 2'-N-acetylparomamine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40541", "l": "H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin] => 10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54922", "l": "13-cis-retinal + H(+) + NADPH => 13-cis-retinol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730840", "l": "Activation of RAC1 by VAV (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36259", "l": "a 1-(1-hydroxyalkyl)-sn-glycerol = an aldehyde + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49861", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.-", "l": "\"Dipeptidases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604732", "l": "Autocatalytic activation of proMMP13 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36132", "l": "(indol-3-yl)acetate + S-adenosyl-L-methionine => methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56236", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015626", "l": "L-diaminopimelate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985591", "l": "SLIT2-bound ROBO1 binds MYO9B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42969", "l": "cytidine(56) in tRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.17"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.20"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11459", "l": "N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59123", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + H(+) <=> 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51943", "l": "(1E,2S)-2-methylbutanal oxime <=> (1Z,2S)-2-methylbutanal oxime"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24733", "l": "anthranilate + H(+) <=> aniline + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52042", "l": "2-aminoprop-2-enoate + S-sulfanyl-L-cysteine => L-cystine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15805", "l": "(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate"}, {"i": "EC:6.3.3.3", "l": "\"Dethiobiotin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48928", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372388", "l": "fructose 1,6-bisphosphate + H2O => fructose 6-phosphate + orthophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49554", "l": "H(+) + L-lysyl-[protein] + lactate => H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33348", "l": "2-iminoacetate + H2O => glyoxylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693243", "l": "RHOD translocates to the Golgi membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376851", "l": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45295", "l": "2-glyceryl-prostaglandin G2 + AH2 <=> 2-glyceryl-prostaglandin H2 + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809680", "l": "MTMR12 binds MTM1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-451033", "l": "(S)-Malate <=> Fumarate + H2O (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36777", "l": "alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428917", "l": "G13 activation by TP receptor (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782224", "l": "3' incision by ERCC5 (XPG) in TC-NER (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63816", "l": "ATP + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine + spermidine = AMP + diphosphate + H(+) + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682709", "l": "LGI4 binds ADAM22,23,11 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.4", "l": "\"Minus-end-directed kinesin ATPase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801195", "l": "STEAP3 binds BNIP3L (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28990", "l": "H(+)(in) + N-acetylneuraminate(in) <=> H(+)(out) + N-acetylneuraminate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.30", "l": "\"Acyl-lipid (8-3)-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11106", "l": "H(+) + hercynine + S-adenosyl-L-homocysteine => N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015554", "l": "tartrate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40791", "l": "H2O + hexacosanoyl-CoA = CoA + H(+) + hexacosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395340", "l": "Formation of hydroxyallysine by LOX (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619657", "l": "EGR2 and SOX10 bind the PRX gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22376", "l": "uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA"}, {"i": "EC:5.4.99.12", "l": "\"tRNA pseudouridine(38-40) synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16050", "l": "adenosylcob(III)inamide-GDP + alpha-ribazole => adenosylcob(III)alamin + GMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6802973", "l": "PLK3 phosphorylates CDC25C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047024", "l": "5alpha-androstane-3beta,17beta-diol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0015159", "l": "polysaccharide transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50017", "l": "H2O + octanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + octanoyl-4'-phosphopantetheine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424485", "l": "Release of p-PLCG1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54962", "l": "AMP + dinor-OPDA-CoA + diphosphate => ATP + CoA + dinor-OPDA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13923", "l": "gibberellin A12 aldehyde + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-oate + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38165", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65102", "l": "an hexadecanoyl-acylglycerol + CoA => a 1-acylglycerol + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18218", "l": "2-oxoglutarate + an alkane-alpha,omega-diamine => an omega-aminoaldehyde + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610723", "l": "GLI proteins bind SUFU (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046175", "l": "Further sulfation on galactose residues produces KSPG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654510", "l": "FGFRL1 binds SPRED1/2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53199", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 16alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45567", "l": "2-epi-5-epi-valiolone <=> 5-epi-valiolone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59022", "l": "(9Z,12Z)-octadecadienoate + di-(9Z,12Z)-octadecadienoylglycerol + H(+) => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38986", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8960973", "l": "RLBP1:11cRAL dissociates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34174", "l": "L-aspartate 4-semialdehyde + pyruvate <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013023", "l": "RHOB GEFs activate RHOB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64333", "l": "ATP + CoA + nicotinate => AMP + diphosphate + nicotinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34768", "l": "5,10-methenyltetrahydrofolate + H2O => 5-formyltetrahydrofolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694567", "l": "pp1a forms a dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70494", "l": "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15590", "l": "2-oxoglutarate + D-4-hydroxyphenylglycine => 4-hydroxyphenylglyoxylate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27441", "l": "NAD(+) + xylitol = D-xylose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802927", "l": "BRAF and RAF fusion mutant dimers are phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48651", "l": "lipoxin A4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-lipoxin A4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59305", "l": "3'-phosphoadenylyl sulfate + firefly L-luciferin => adenosine 3',5'-bisphosphate + firefly L-sulfoluciferin + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25867", "l": "H2O + N(1)-acetylspermidine + O2 <=> 4-acetamidobutanal + H2O2 + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20935", "l": "L-erythrulose 1-phosphate <=> dihydroxyacetone phosphate + formaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52697", "l": "a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-galactose => a 1,2-diacyl-3-O-[alpha-D-galactopyranosyl-(1->2)-alpha-D-glucopyranosyl]-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033288", "l": "ATPase-coupled hydroxyectoine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047253", "l": "alpha-1,6-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389463", "l": "Proteinase-activated receptors can bind thrombin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866304", "l": "pre-VLDL binds lipids to form VLDL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0004308", "l": "exo-alpha-sialidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005464", "l": "UDP-xylose transmembrane transporter activity"}, {"i": "REACT:R-HSA-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41361", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => H(+) + hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163310", "l": "TFAM binds to mitochondrial promoters (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70501", "l": "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14356", "l": "3-dehydro-L-gulonate 6-phosphate + H(+) <=> CO2 + L-xylulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26428", "l": "ADP + CTP + 2 H(+) + L-glutamate + phosphate => ATP + H2O + L-glutamine + UTP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047073", "l": "2,4'-dihydroxyacetophenone dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29561", "l": "1-phospho-alpha-D-glucuronate + 2 H(+) + UMP => H2O + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28357", "l": "decanoyl-CoA + FAD + H(+) <=> (2E)-decenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10433", "l": "2-(acetamidomethylene)succinate + H(+) + 2 H2O => acetate + CO2 + NH4(+) + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58335", "l": "(E)-non-2-en-1-ol + NADP(+) <=> (E)-non-2-enal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46976", "l": "(S)-6-hydroxynicotine + O2 = 6-hydroxy-N-methylmyosmine + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46106", "l": "corticosterone + H2O + 2 oxidized [adrenodoxin] => 21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21161", "l": "acetyl-CoA + ADP + oxaloacetate + phosphate => ATP + citrate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38127", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol = 1-octadecanoyl-2-(9Z)-octadecenoylglycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64246", "l": "an N-(fatty acyl)-glycine + CoA + H(+) => a fatty acyl-CoA + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50778", "l": "(E)-hex--2-enal + H(+) + NADPH => hexanal + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60905", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => 13-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181155", "l": "The NODAL Receptor binds NODAL ligands (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19099", "l": "A + 2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + 2 H(+) + 2 phosphate => AH2 + 2 ATP + benzoyl-CoA + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56948", "l": "pyruvate + UTP = H(+) + phosphoenolpyruvate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30407", "l": "hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin] = oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.97.1.12", "l": "\"Photosystem I\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54388", "l": "1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49438", "l": "choloyl-CoA + deoxycholate => cholate + deoxycholoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3229181", "l": "CALM1:Ca2+ binds CNG channel (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60069", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H(+) + 3 NADH + 3 O2 => 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 4 H2O + 3 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102103", "l": "demethoxycurcumin synthase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685953", "l": "SIRT6 deacetylates RBBP8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19319", "l": "5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070909", "l": "glutamate:gamma-aminobutyric acid antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40817", "l": "(9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198983", "l": "NKG2D homodimer interacting with ligands (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63101", "l": "H(+) + ilicicolin C + NADPH + O2 => ascochlorin + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34278", "l": "2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine <=> 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625426", "l": "Retrograde IFT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389963", "l": "alpha-tubulin:GTP:Cofactor B  +Cofactor E ->  alpha-tubulin:GTP: Cofactor E +Cofactor B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51361", "l": "H2O + N-(9Z-octadecenoyl)-L-leucine => (9Z)-octadecenoate + L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690702", "l": "LYN phosphorylates CD22 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42472", "l": "dibenzo-p-dioxin + NADH + O2 = 2,2',3-trihydroxydiphenyl ether + H(+) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018758", "l": "RHOH binds effectors at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56365", "l": "13-dihydrocarminomycin + H(+) + NADPH + O2 => carminomycin + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28989", "l": "H(+)(out) + N-acetylneuraminate(out) => H(+)(in) + N-acetylneuraminate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2032775", "l": "YAP1 binds TEAD1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40982", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11781", "l": "3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33476", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphinganine => a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28909", "l": "3-(3-hydroxyphenyl)propanoate(out) + H(+)(out) => 3-(3-hydroxyphenyl)propanoate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30753", "l": "AMP + diphosphate + hexadecanoyl-CoA => ATP + CoA + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57458", "l": "4-O-(beta-D-glucosyl)-trans-sinapate + H(+) + UDP => E-sinapate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50961", "l": "cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine => H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.2", "l": "\"Lysosomal Pro-Xaa carboxypeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27904", "l": "1,3,7-trimethylurate + ubiquinol-0 => caffeine + H2O + ubiquinone-0"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811427", "l": "COPI vesicle uncoating at the ER (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043738", "l": "reduced coenzyme F420 dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16224", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45598", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647980", "l": "mature RAS proteins translocate to plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004090", "l": "carbonyl reductase (NADPH) activity"}, {"i": "REACT:R-HSA-8937419", "l": "CBR3 reduces DOX to DOXOL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30821", "l": "allantoate + H(+) => allantoin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33548", "l": "H2O + lanosteryl hexadecanoate => H(+) + hexadecanoate + lanosterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209921", "l": "Monoiodinated tyrosine can be deiodinated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65554", "l": "an N-acyl-sphingoid base + lactose => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24148", "l": "D-glyceraldehyde 3-phosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2R)-3-phosphoglycerate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.2.7.6", "l": "\"Glyceraldehyde-3-phosphate dehydrogenase (ferredoxin)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11121", "l": "cyanate + 3 H(+) + hydrogencarbonate => 2 CO2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15152", "l": "O2 + pyridoxine 5'-phosphate <=> H2O2 + pyridoxal 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672961", "l": "PP2A dephosphorylates inactive RAFs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24318", "l": "(+)-copalyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35793", "l": "H(+) + kanamycin X + UDP => 2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-kanosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44222", "l": "15-hydroxypentadecanoyl-CoA + AMP + diphosphate => 15-hydroxypentadecanoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11669", "l": "[(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O => [(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40625", "l": "2,3-ditetradecanoyl-sn-glycerol + H(+) + tetradecanoate => H2O + tritetradecanoylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050265", "l": "RNA uridylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047681", "l": "aryl-alcohol dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047723", "l": "inosinate nucleosidase activity"}, {"i": "KEGG.REACTION:R01128"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31842", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-3-dehydro-6-deoxy-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20010", "l": "2-hydroxy-2-methylpropanenitrile + UDP-alpha-D-glucose => H(+) + linamarin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20748", "l": "2-oxoglutarate + O2 + penicillin N = CO2 + deacetoxycephalosporin C + H2O + succinate"}, {"i": "EC:1.14.20.1", "l": "\"Deacetoxycephalosporin-C synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66866", "l": "diphosphate + quiannulatene => (2E,6E,10E,14E)-geranylfarnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2203480", "l": "COLEC11 binds ligands (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4341016", "l": "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38666", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110244", "l": "Excision of FapyG by OGG1 glycosylase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56647", "l": "a uridine in mRNA <=> a pseudouridine in mRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35770", "l": "dihydrosterigmatocystin + S-adenosyl-L-methionine <=> 8-O-methyldihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38918", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72691", "l": "Formation of the 43S pre-initiation complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62207", "l": "1-propanol + 2 [Fe(III)cytochrome c] <=> 2 [Fe(II)cytochrome c] + 2 H(+) + propanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63443", "l": "(2R)-3-phosphoglycerate + GTP + H(+) <=> 3-[(R)-glyceryl]-diphospho-5'-guanosine + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15659", "l": "3-methylcatechol + CO2 + NADH => 1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980048", "l": "DLL1 binds NOTCH2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17174", "l": "glutathionylspermidine + H2O => glutathione + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64272", "l": "benzylamine + pyruvate = benzaldehyde + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49964", "l": "5,10-dihydrophenazine + O2 = H2O2 + phenazine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35790", "l": "paromamine + UDP-alpha-D-kanosamine <=> H(+) + kanamycin C + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876472", "l": "NPC2 binds CHOL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050336", "l": "thioethanolamine S-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56302", "l": "[thioredoxin]-disulfide + H(+) + hydrogen sulfide + L-cysteinyl-[protein] => [thioredoxin]-dithiol + S-sulfanyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849102", "l": "SRMS phosphorylates PTK6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50007", "l": "H(+) + NADPH + O2 + tetracycline <=> 11a-hydroxytetracycline + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43665", "l": "ATP + hydrogencarbonate + tetracosanoyl-CoA => 2-carboxytetracosanoyl-CoA + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0016505", "l": "peptidase activator activity involved in apoptotic process"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30664", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole => hapalindole H"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803047", "l": "DCD peptide binds bacterial membrane phospholipids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28891", "l": "H(+)(in) + putrescine(in) = H(+)(out) + putrescine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59569", "l": "4-aminobutanoate + ATP + L-histidine => ADP + H(+) + L-homocarnosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032050", "l": "clathrin heavy chain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52079", "l": "13-(9Z-hexadecenoyloxy)-octadecanoate + H2O <=> (9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033832", "l": "alpha,alpha-trehalose phosphorylase (configuration-retaining) activity"}, {"i": "RHEA:16257", "l": "alpha,alpha-trehalose + phosphate = alpha-D-glucose + alpha-D-glucose 1-phosphate"}, {"i": "MetaCyc:RXN-4441"}, {"i": "EC:2.4.1.231", "l": "\"Alpha,alpha-trehalose phosphorylase (configuration-retaining)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295613", "l": "SPRY2 binds GRB2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4093329", "l": "EFNBs bind SDCBP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353524", "l": "XP-C binds to RAD23B forming a heterodimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29104", "l": "5 H(+)(in) + menaquinone-8 + NADH => 4 H(+)(out) + menaquinol-8 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55442", "l": "H(+) + H2O + maniladiol + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693561", "l": "RAD51 binds BRCA2 at resected DNA DSBs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814555", "l": "Integrator complex processes the 3' end of snRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50048", "l": "ATP + cholate(in) + H2O = ADP + cholate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51950", "l": "2-hydroxy-2-methylbutanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-2-methylbutanenitrile + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53349", "l": "5,6-dihydrouridine(20a) in tRNA + NAD(+) => H(+) + NADH + uridine(20a) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199014", "l": "CD96 binds PVR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46881", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061634", "l": "alpha-D-xyloside xylohydrolase"}, {"i": "EC:3.2.1.177", "l": "\"Alpha-D-xyloside xylohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19507", "l": "(indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP => indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34305", "l": "L-pipecolate + NH4(+) => L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625424", "l": "The retrograde IFT train dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55491", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-cassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13310", "l": "H2O + NAD(+) + vanillin => 4-hydroxy-3-methoxybenzoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166015", "l": "Association of LBP with LPS (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33134", "l": "L-phenylalanine + tetrahydro-4-hydroxyphenylpyruvate <=> 3-phenylpyruvate + tetrahydrotyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29150", "l": "2 H(+)(in) + nitrate + ubiquinol-8 <=> 2 H(+)(out) + H2O + nitrite + ubiquinone-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40641", "l": "(9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49968", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009017", "l": "succinylglutamate desuccinylase activity"}, {"i": "MetaCyc:SUCCGLUDESUCC-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102997", "l": "progesterone 5beta- reductase activity"}, {"i": "MetaCyc:RXN-9726"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608855", "l": "PRICKLE1 is degraded by the proteasome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37499", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23281", "l": "acetyl-CoA + cysteamine => CoA + S-acetylcysteamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59081", "l": "bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose => 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11059", "l": "4-aminobenzoate + 2 H(+) + NADPH + O2 <=> 4-aminophenol + CO2 + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20147", "l": "2-[3-carboxy-3-(methylammonio)propyl]-L-histidine + H(+) + S-adenosyl-L-homocysteine => 2-(3-amino-3-carboxypropyl)-L-histidine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034890", "l": "endosulfan diol hydrolyase (cyclizing) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40499", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905761", "l": "SCF ubiquitin ligase complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19116", "l": "(8Z,11Z,14Z)-heptadecatrienal + A + H2O <=> (8Z,11Z,14Z)-heptadecatrienoate + AH2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2559439", "l": "CD14:LPS binds CR3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227698", "l": "NLRX1 inhibits IPS1 signaling (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140584", "l": "chromatin extrusion motor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192677", "l": "Newly synthesized vRNP for export (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990460", "l": "leptin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052650", "l": "NADP-retinol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57107", "l": "[(1->4)-alpha-D-galacturonosyl](n) <=> 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-2)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848713", "l": "PTK6 binds BCAR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72621", "l": "Ribosomal scanning  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.-.-", "l": "\"Acyltransferases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8986083", "l": "USP33 deubiquitinates ROBO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928627", "l": "EPHB phosphorylates TIAM1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5225649", "l": "RBBP7 binds histone H3 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65956", "l": "ATP + estrone 3-sulfate(out) + H2O = ADP + estrone 3-sulfate(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51050", "l": "AH2 + androst-4-ene-3,17-dione => 5alpha-androstan-3,17-dione + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937050", "l": "Pellino ubiquitinates hp-IRAK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23543", "l": "ATP + L-glutamate + tRNA(Glu) <=> AMP + diphosphate + L-glutamyl-tRNA(Glu)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10355", "l": "an N-acetylarylalkylamine + H2O <=> acetate + an arylalkylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196773", "l": "COASY phosphorylates DP-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39381", "l": "(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+) => (2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64802", "l": "(4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + 2 H(+) + NADH + NH4(+) => NAD(+) + S-(2-aminoethyl)-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018778", "l": "DL-2 haloacid dehalogenase activity"}, {"i": "MetaCyc:RXN-9150"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49479", "l": "2 H2O + L-1-piperideine-6-carboxylate + NAD(+) <=> H(+) + L-2-aminoadipate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54635", "l": "2-oxoglutarate + O2 + tetradecanoyl-CoA <=> 2-hydroxytetradecanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63411", "l": "6-chloropyridine-2,3,5-triol + FADH2 + O2 <=> 3,6-dihydroxypyridine-2,5-dione + chloride + FAD + 3 H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53339", "l": "5,6-dihydrouridine(20) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(20) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59706", "l": "D-cellohexaonate + H(+) => D-cellohexaono-1,5-lactone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21080", "l": "ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine"}, {"i": "EC:2.5.1.6", "l": "\"Methionine adenosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102498", "l": "maltose glucosidase activity"}, {"i": "MetaCyc:RXN-15910"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63332", "l": "alpha-L-arabinose = beta-L-arabinose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.21", "l": "\"Astacin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42193", "l": "(9Z)-pentadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-pentadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19495", "l": "alpha-D-glucose 1-phosphate + D-glucose => D-cellobiose + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052918", "l": "dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60678", "l": "(S)-(-)-citronellal + H(+) + NADH => (S)-(-)-citronellol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5252072", "l": "AZGP1 binds PIP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70427", "l": "PGM:Mg2+ isomerise G1P to G6P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961619", "l": "CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45639", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866941", "l": "MID1IP1 binds THRSP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61343", "l": "(S)-methylmalonyl-CoA + H(+) <=> CO2 + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30610", "l": "A + all-trans-phytofluene <=> AH2 + all-trans-zeta-carotene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22880", "l": "2-oxoglutarate + L-arogenate = L-glutamate + prephenate"}, {"i": "EC:2.6.1.79", "l": "\"Glutamate--prephenate aminotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-421835", "l": "trans-Golgi Network Vesicle Scission (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66540", "l": "A + cholesta-5,7-dien-3beta-ol + H2O = AH2 + cholesta-5,7-dien-3beta,25-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65415", "l": "dAMP(in) + NAD(+)(out) <=> dAMP(out) + NAD(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3296233", "l": "T2Rs bind bitter-tasting compounds (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019156", "l": "isoamylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21137", "l": "(R)-carnitine + acetyl-CoA => CoA + O-acetyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36978", "l": "AMP + phosphate <=> adenine + alpha-D-ribose 1,5-bisphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1484099", "l": "MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36943", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16205", "l": "H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] = N(6)-(D-fructosyl)-L-lysyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41046", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + octanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-octanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909729", "l": "Activation of JAK kinases (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40419", "l": "H2O + phytanoyl-CoA = 3,7,11,15-tetramethylhexadecanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784402", "l": "Spontaneous hydrolysis of 1-pyrroline-3-hydroxy-5-carboxylate to 4-OH-L-glutamate semialdehyde (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373720", "l": "FADK1 interaction with DCC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12423", "l": "ATP + D-tagatofuranose 6-phosphate <=> ADP + D-tagatofuranose 1,6-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090415", "l": "7-hydroxymethyl chlorophyll a reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53131", "l": "delta-carotene <=> epsilon-carotene"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050589", "l": "leucocyanidin oxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61379", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O <=> 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16482", "l": "3 S-adenosyl-L-methionine => 3 H(+) + nicotianamine + 3 S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0061630", "l": "ubiquitin protein ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41092", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 1-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46617", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799332", "l": "ATR phosphorylates TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428293", "l": "IGF2BP2 binds specific RNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12910", "l": "2 [Fe(II)cytochrome] + 2 H(+) + nitrate => 2 [Fe(III)cytochrome] + H2O + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18033", "l": "benzoate + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxybenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.92", "l": "\"Benzoate 4-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798374", "l": "DYRK2 phosphorylates TP53 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40601", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46132", "l": "cholesterol + H(+) + NADPH + O2 = 25-hydroxycholesterol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4549368", "l": "Defective ALG2 does not transfer a second Man to N-glycan precursor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77081", "l": "Formation of the CE:GMP intermediate complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46734", "l": "(2S,6)-dimethylheptanoyl-CoA => (2R,6)-dimethylheptanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28009", "l": "H2O + N(alpha)-methyl-L-tryptophan + O2 <=> formaldehyde + H2O2 + L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026579", "l": "NTRK2 phosphorylates PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32888", "l": "all-trans-beta-carotene + O2 => 2 all-trans-retinal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56963", "l": "a ribonucleoside 5'-triphosphate + pyruvate <=> a ribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810843", "l": "Envoplakin binds periplakin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.22", "l": "\"Aminopeptidase I\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008577", "l": "IL37:IL18R1 binds SIGIRR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052755", "l": "reduced coenzyme F420:quinone oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621385", "l": "EGR1 binds TRIB1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20182", "l": "alpha-D-mannose derivative + UDP-alpha-D-glucose => 6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204169", "l": "PDP dephosphorylates p-lipo-PDH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0051033", "l": "RNA transmembrane transporter activity"}, {"i": "REACT:R-HSA-203906", "l": "Exportin complex translocates pre-miRNA to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55760", "l": "a fatty acyl-[ACP] + a lyso-ornithine lipid = an N(2)-[(3R)-3-(acyloxy)acyl]-L-ornithine lipid + holo-[ACP]"}, {"i": "EC:2.3.1.270", "l": "\"Lyso-ornithine lipid O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008743", "l": "L-threonine 3-dehydrogenase activity"}, {"i": "RHEA:13161", "l": "L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + H(+) + NADH"}, {"i": "EC:1.1.1.103", "l": "\"L-threonine 3-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114544", "l": "p115-RhoGEF activation of RHOA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24941", "l": "D-glutamate + H(+) + NADPH => (R)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33886", "l": "2-deoxy-scyllo-inosamine + NAD(+) <=> 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64311", "l": "3-aminobutanoate + pyruvate <=> acetoacetate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877941", "l": "RUNX2 binds SMAD1 in the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856945", "l": "PP2A methylation by LCMT1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451311", "l": "Activation of Ca-permeable Kainate receptors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-178208", "l": "SMAD7 binds to SMURF2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31891", "l": "2-hydroxy-1-phenyl-1-propanone + NADP(+) = 1-phenyl-1,2-propanedione + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58727", "l": "adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.24", "l": "\"Succinate-semialdehyde dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592316", "l": "Initial activation of proMMP1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654625", "l": "Activated FGFR3 binds SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170975", "l": "p-FRS2 binds CRKL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56643", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032556", "l": "pyrimidine deoxyribonucleotide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18490", "l": "cyanate + H(+) + hydrogencarbonate => carbamate + CO2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047333", "l": "dihydrostreptomycin-6-phosphate 3'-alpha-kinase activity"}, {"i": "MetaCyc:2.7.1.88-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38883", "l": "a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-378956", "l": "Luteinizing hormone is a heterodimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48509", "l": "cholate + NADP(+) => 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16223", "l": "3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706340", "l": "Active FLT3:p-Y-GRB10 binds PIK3R1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874079", "l": "PTK2 binds activated MET (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23248", "l": "myo-inositol + S-adenosyl-L-methionine = 1D-4-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.129", "l": "\"Inositol 4-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603419", "l": "Activated NTRK3 binds SRC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64690", "l": "3-O-(N-acetyl-alpha-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP => L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14131", "l": "3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH => cholate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210294", "l": "Interaction of PECAM-1 and SHP-2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019139", "l": "cytokinin dehydrogenase activity"}, {"i": "MetaCyc:1.5.99.12-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2509831", "l": "ITPA hydrolyses XTP to XMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420131", "l": "The PACAP receptor binds PACAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13332", "l": "A + a 3-oxosteroid <=> a 3-oxo-Delta(1)-steroid + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28468", "l": "pyridoxamine(out) => pyridoxamine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395768", "l": "LPL hydrolyses TGs from mature CMs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985929", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54221", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene => all-trans-neurosporene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193705", "l": "IKKbeta phosphorylates IkB causing NF-kB to dissociate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59325", "l": "D-xylose + O2 => D-xylono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8957241", "l": "TP73 tetramer translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13742", "l": "3-phenylpyruvate + L-tryptophan => indole-3-pyruvate + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362386", "l": "Glycosylation of Hh (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25294", "l": "acetaldehyde + H2O + NAD(+) = acetate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.3", "l": "\"Aldehyde dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47372", "l": "a quinone + D-glucose = a quinol + D-glucono-1,5-lactone"}, {"i": "EC:1.1.5.9", "l": "\"Glucose 1-dehydrogenase (FAD, quinone)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159733", "l": "Furin cleaves pro-factor X to factor X (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9710101", "l": "CASP4, CASP5 cleave GSDMD (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.193", "l": "\"Ginsenosidase type I\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17202", "l": "2-dehydro-3-deoxy-L-arabinonate => 2,5-dioxopentanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444606", "l": "T1R2/T1R3 dimer is a sweet taste receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58545", "l": "2 L-ascorbate + N-tetradecanoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-tetradecanoyl-(2S)-hydroxyglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38248", "l": "(9Z)-hexadecenoyl-CoA + hexadecan-1-ol => 1-O-hexadecyl (9Z)-hexadecenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10504", "l": "7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH + O2 = 7alpha,12alpha-dihydroxycholest-4-en-3-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635839", "l": "ULK3:SUFU dissociates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391866", "l": "Phosphorylation of FAK by Src kinase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004814", "l": "arginine-tRNA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16045", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203070", "l": "Association of profilin with monomeric actin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730841", "l": "Phosphorylation and activation of VAV (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16097", "l": "acetylpyruvate + H2O = acetate + H(+) + pyruvate"}, {"i": "EC:3.7.1.6", "l": "\"Acetylpyruvate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28346", "l": "7,8-dihydroneopterin 3'-triphosphate = 7,8-dihydromonapterin 3'-triphosphate"}, {"i": "EC:5.1.99.7", "l": "\"Dihydroneopterin triphosphate 2'-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9603784", "l": "PEX19:class I PMP binds PEX3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32306", "l": "(2R)-homocitrate <=> (1R,2S)-homoisocitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021334", "l": "STAT1 binds HEY1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23901", "l": "cis-stilbene oxide + H2O => (1R,2R)-hydrobenzoin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202724", "l": "P-selectin binds P-selectin ligand (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645598", "l": "RRAGC,D hydrolyzes GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009488", "l": "IL34 binds CSF1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428127", "l": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42210", "l": "an omega-(methylsulfinyl)-alkyl-glucosinolate + H2O + NADP(+) => an omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168935", "l": "viral dsRNA binds DDX58 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16879", "l": "CO2 + hypotaurine => 3-sulfino-L-alanine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793956", "l": "Defective B4GALT1 does not add Gal to N-glycan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56299", "l": "2-oxo-3-sulfanylpropanoate + L-cysteinyl-[protein] <=> pyruvate + S-sulfanyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27947", "l": "dopamine + H2O + O2 => 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2106625", "l": "Duplex siRNA is loaded into Argonaute (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13034", "l": "aldehydo-D-galactose 6-phosphate => keto-D-tagatose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58861", "l": "4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35146", "l": "benzoyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 2,4,6-trihydroxybenzophenone + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607740", "l": "PKC-delta phosphorylates CARD9 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5681987", "l": "LC3 is cleaved by ATG4 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416725", "l": "SEMA6D binds to PLXNA1:TREM2:DAP12 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18422", "l": "acetyl-CoA + chloramphenicol => chloramphenicol 3-acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58614", "l": "H2O + 2 monodehydro-L-ascorbate radical + N-octanoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-octanoylglycine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57287", "l": "a guanosine in RNA + methylglyoxal <=> an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52334", "l": "3 H(+) + 2 H2O + 2 L-citrulline + 2 nitric oxide + oxidized [flavodoxin] => 2 N(omega)-hydroxy-L-arginine + 2 O2 + reduced [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381109", "l": "IRE1 binds IRE1 forming dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47481", "l": "deoxycholate + NADP(+) => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1861789", "l": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5689000", "l": "AADAC deacetylates PHEN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59191", "l": "L-histidine <=> D-histidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350391", "l": "RHO1:GTP binds to activated DAAM (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5660662", "l": "ASC binds Caspase-8 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0044013", "l": "H2B histone acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6795473", "l": "PDPK1 phosphorylates SGK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13597", "l": "1,4-diguanidinobutane + H2O = agmatine + urea"}, {"i": "EC:3.5.3.20", "l": "\"Diguanidinobutanase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41257", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64331", "l": "(7Z)-octadecenoyl-CoA + cholesterol <=> cholesteryl (7Z)-octadecenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380930", "l": "Phosphorylated AMPK binds AMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23111", "l": "D-arabinono-1,4-lactone + H2O <=> D-arabinonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32655", "l": "a carboxylate + eugenol + NADP(+) = a coniferyl ester + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35488", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2,3-dihydrogenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.9", "l": "\"Nucleotide diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31290", "l": "H(+) + oxidized [electron-transfer flavoprotein] + propanoyl-CoA <=> acryloyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50129", "l": "NAD(+) + resolvin D1 => 17-oxoresolvin D1 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41118", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638007", "l": "RP2 activates the GTPase activity of ARL3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975633", "l": "atROL binds to RBP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57092", "l": "AH2 + S-(methylsulfanyl)glutathione = A + glutathione + methanethiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.-", "l": "\"Pentosyltransferases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43125", "l": "guanosine(10) in tRNA + 2 S-adenosyl-L-methionine => 2 H(+) + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61607", "l": "[DsbA protein]-dithiol + [DsbB protein]-disulfide <=> [DsbA protein]-disulfide + [DsbB protein]-dithiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605624", "l": "Beta-galactosidase hydrolyses GM1 to GM2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877192", "l": "RUNX1 binds FOXP3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36444", "l": "dihydrochanoclavine-I aldehyde => 6,8-dimethyl-6,7-didehydroergoline + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39429", "l": "(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+) => (2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672019", "l": "Leucodopachrome, L-Dopaquinone transform to Dopachrome, L-Dopa (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004618", "l": "phosphoglycerate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47393", "l": "H2O + hexadecanoate ester => an aliphatic alcohol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865256", "l": "CDKN1A gene expression is stimulated by TFAP2A and repressed by TFAP2C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42726", "l": "2'-O-methylguanosine(2922) in 27S pre-rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(2922) in 27S pre-rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264865", "l": "Caspase-mediated cleavage of Lamin A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11953", "l": "3-hydroxypyruvate => 2-hydroxy-3-oxopropanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0008989", "l": "rRNA (guanine-N1-)-methyltransferase activity"}, {"i": "MetaCyc:RRNA-GUANINE-N1--METHYLTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103106", "l": "brassinolide 23-O-glucosyltransferase activity"}, {"i": "MetaCyc:RXNQT-4397"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45569", "l": "[heparosan](n) => [acharan](n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "75.848614326174683", "identifiers": [{"i": "GO:0000030", "l": "mannosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110212", "l": "NTHL1 glycosylase mediated recognition and binding of dihydrouracil (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18076", "l": "(S)-dihydroorotate + A <=> AH2 + orotate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34450", "l": "dTDP-6-deoxy-beta-L-talose + NAD(+) <=> dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32261", "l": "1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde => beta-D-fructose 1-phosphate + methylglyoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2314686", "l": "Aspirin acetylates PTGS2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11962", "l": "(S)-2-succinylamino-6-oxoheptanedioate + L-glutamate => 2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102211", "l": "unsaturated rhamnogalacturonyl hydrolase activity"}, {"i": "RHEA:30927", "l": "2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnose + H2O = 5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose"}, {"i": "EC:3.2.1.172", "l": "\"Unsaturated rhamnogalacturonyl hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983161", "l": "Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52559", "l": "3-dehydro-D-erythronate + ATP <=> 3-dehydro-4-O-phospho-D-erythronate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75244", "l": "FASL binds FAS Receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694527", "l": "Loss of SAR1B GTPase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432712", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426149", "l": "SREBP1A,1C,2 binds the ELOVL6 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37826", "l": "(R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 <=> 2,4-dichlorophenol + CO2 + pyruvate + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "63.234144983841738", "identifiers": [{"i": "GO:0016701", "l": "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen"}, {"i": "EC:1.13.-.-", "l": "\"Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O(2)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48265", "l": "H2O + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] => H(+) + S-sulfanyl-L-cysteinyl-[SoxY protein] + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57049", "l": "AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] => 2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810376", "l": "ING2 binds PI5P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9696271", "l": "RND1 binds effectors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010872", "l": "SLIT2 binds Dystroglycan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2574845", "l": "AJUBA binds centrosome-associated AURKA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15713", "l": "a beta-D-galactoside + acetyl-CoA = a 6-acetyl-beta-D-galactoside + CoA"}, {"i": "EC:2.3.1.18", "l": "\"Galactoside O-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11723", "l": "ATP + 2 H2O + N-methylhydantoin <=> ADP + 2 H(+) + N-carbamoylsarcosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045481", "l": "6-endo-hydroxycineole dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508282", "l": "SYK is a substrate for JAK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.10.1.-", "l": "\"Molybdenumtransferases or tungstentransferases with sulfide groups as acceptors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47902", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate => ganglioside GM3 (d18:1(4E)) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2130706", "l": "MHC class II antigen processing (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65486", "l": "CoA + hexyl hexanoate => hexan-1-ol + hexanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810392", "l": "TMEM55B translocates to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870466", "l": "RGGT:CHM binds RABs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64364", "l": "prostaglandin G2 = (15S)-15-hydroperoxy-prostaglandin E2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003842", "l": "1-pyrroline-5-carboxylate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47797", "l": "an aralkylamine + H2O + 2 oxidized [azurin] => an aromatic aldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247837", "l": "WNT ligands traffic to the Golgi (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43595", "l": "all-trans-zeaxanthin + O2 <=> (3R)-3-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592246", "l": "Expression of TFAM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66210", "l": "(2E,8R)-8-hydroxynonenoyl-CoA + H2O2 => (8R)-8-hydroxynonanoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52844", "l": "3,4-dihydroxybenzoate + UDP-alpha-D-glucose = 1-O-(3,4-dihydroxy-benzoyl)-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59311", "l": "D-galactono-1,5-lactone + H2O <=> D-galactonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57055", "l": "3-oxoisoapionate + H(+) <=> CO2 + L-erythrulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22044", "l": "ATP + H(+)(in) + H2O + K(+)(out) = ADP + 2 H(+)(out) + K(+)(in) + phosphate"}, {"i": "EC:7.2.2.19", "l": "\"H(+)/K(+)-exchanging ATPase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37849", "l": "daunorubicin + 2 H2O + NADP(+) => 13-dihydrodaunorubicin + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110244", "l": "Excision of FapyG by OGG1 glycosylase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018836", "l": "alkylmercury lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682020", "l": "MRN complex binds shortened telomeres (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956684", "l": "ITCH polyubiquitinates TP73 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1297354", "l": "Acrosin Cleavage (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40259", "l": "(2E)-hexadecenedioyl-CoA + H2O = (3S)-hydroxyhexadecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673349", "l": "WNT5 binds FZD7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58770", "l": "1-O-(1Z-hexadecenyl)-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-O-(1Z-hexadecenyl)-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38187", "l": "19-oxotestosterone + O2 + reduced [NADPH--hemoprotein reductase] = 17beta-estradiol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49142", "l": "dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29027", "l": "2 H(+)(in) + L-glutamate(in) = 2 H(+)(out) + L-glutamate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40198", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3262512", "l": "G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210439", "l": "glutamate uptake by astrocytes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65431", "l": "deamido-NAD(+)(in) + NAD(+)(out) <=> deamido-NAD(+)(out) + NAD(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376121", "l": "Bnip2 interacts with CDO complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45114", "l": "13-hydroxy-gamma-tocopherol + H2O + NADP(+) => gamma-tocopherol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65601", "l": "4,5,8-trihydroxycasbene + 2 NAD(+) => 2 H(+) + jolkinol C + 2 NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66599", "l": "O2 + 2 tyramine <=> 2 dopamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12135", "l": "ATP + Cd(2+)(in) + H2O <=> ADP + Cd(2+)(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49833", "l": "a fatty aldehyde + H2O + NAD(+) => a fatty acid + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106144", "l": "fraxetin 5-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56836", "l": "[PQQ precursor protein] + S-adenosyl-L-methionine = 5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine"}, {"i": "EC:1.21.98.4", "l": "\"PqqA peptide cyclase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626928", "l": "CREBBP binds FOXO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379887", "l": "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32877", "l": "a fatty acid + glycerol + H(+) => a 1-acyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44612", "l": "3-(all-trans-decaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-decaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60485", "l": "CTP + UTP => cyclic CMP-UMP + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24550", "l": "a carboxylate + L-lysine => an N(6)-acyl-L-lysine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44642", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + ADP => a 2'-deoxyribonucleoside 5'-diphosphate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225951", "l": "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112430", "l": "Formation of P-TEFb complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805109", "l": "CDK2 phosphorylates TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052578", "l": "alpha-farnesene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58832", "l": "24-methylenecycloartanol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}, {"i": "EC:1.14.18.10", "l": "\"Plant 4,4-dimethylsterol C-4-alpha-methyl-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050353", "l": "trimethyllysine dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432361", "l": "Cytosolic PER is degraded by the 26S proteasome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18931", "l": "5-hydroxythiophene-2-carbonyl-CoA + A + H(+) + H2O => AH2 + O2 + thiophene-2-carbonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983142", "l": "Formation of peptide loading complex (PLC) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357904", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20707", "l": "a D-alpha-amino acid + acetyl-CoA <=> an N-acetyl-D-amino acid + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62230", "l": "AH2 + patulin => (E)-ascladiol + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47699", "l": "(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + H2O <=> (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009072", "l": "STAT3 phosphorylation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49867", "l": "(+)-dehydrodiconiferyl acid + 2 a quinone + H2O <=> (+)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202722", "l": "CD48 binds CD244 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49526", "l": "a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49951", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2 <=> (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "61.987634604114341", "identifiers": [{"i": "GO:0022803", "l": "passive transmembrane transporter activity"}, {"i": "REACT:R-HSA-429767", "l": "Passive I- efflux mediated by SMCT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12547", "l": "2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine <=> 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989767", "l": "Expression of TRIB3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24830", "l": "ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide => ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167630", "l": "Formation of Nef CD28 cytoplasmic tail complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36657", "l": "descarbamoylnovobiocin + H(+) + S-adenosyl-L-homocysteine => desmethyldescarbamoylnovobiocin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39534", "l": "3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047000", "l": "2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444705", "l": "T1R1/T1R3 dimer is the umami taste receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45593", "l": "H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352268", "l": "Cleavage of Satb1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672951", "l": "Inactive RAFs bind YWHAB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264679", "l": "Serum albumin binds 2-lysophosphatidylcholine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65590", "l": "4-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-casbene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-450494", "l": "HuR binds mRNAs in the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186786", "l": "Autophosphorylation of PDGF beta receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12337", "l": "carboxymethoxysuccinate => fumarate + glycolate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018447", "l": "chloral hydrate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50390", "l": "5a,11a-dehydrooxytetracycline + H2O + NADP(+) => 5a,11a-dehydrotetracycline + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59645", "l": "D-xylobiono-1,5-lactone + H2O => D-xylobionate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28771", "l": "(2E)-hexadecenoyl-CoA = (9Z)-hexadecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672980", "l": "Dissociation of RAS:RAF complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008273", "l": "calcium, potassium:sodium antiporter activity"}, {"i": "REACT:R-HSA-2514891", "l": "SLC24A1 exchanges 4Na+ for Ca2+, K+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.186"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33783", "l": "1(F)-beta-D-fructosylsucrose + sucrose = 1,6-kestotetraose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686335", "l": "CSF2RA:CSF2RB binds SFTPs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10697", "l": "a long-chain fatty acid + ATP + holo-[mycocerosate synthase] => AMP + diphosphate + long-chain fatty acyl-[mycocerosate synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23089", "l": "ATP + O-alkylglycerone => 1-O-alkylglycerone 3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019151", "l": "galactose 1-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-688137", "l": "RIP2 is K63 polyubiquitinated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56534", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + phosphate => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58036", "l": "8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) = 8-epi-inunolide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602466", "l": "Activation of MT-MMPs by FURIN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46693", "l": "4-hydroxybenzoate + ATP + H(+) => 4-hydroxybenzoyl-5'-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37380", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-994148", "l": "LRRC16A binds F-actin capping protein (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19982", "l": "NADP(+) + S-(hydroxymethyl)glutathione => H(+) + NADPH + S-formylglutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61171", "l": "quercetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> H(+) + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44689", "l": "a 2-acylglycerol + H2O => a fatty acid + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19520", "l": "H2O + N,N-dimethylformamide <=> dimethylamine + formate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32367", "l": "4 [Fe(III)cytochrome c] + L-galactono-1,4-lactone = 4 [Fe(II)cytochrome c] + 5 H(+) + L-dehydroascorbate"}, {"i": "EC:1.3.2.3", "l": "\"L-galactonolactone dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41094", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16329", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14720", "l": "D-erythrose 4-phosphate + H2O + phosphoenolpyruvate <=> 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31374", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine <=> (2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45490", "l": "(2R,3E)-phycocyanobilin + apo-[C-phycocyanin beta-subunit] => [C-phycocyanin beta-subunit]-Cys(84)-phycocyanobilin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668605", "l": "RAC2:GTP binds NOX2 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9038052", "l": "GREB1 binds ESR1:ESTG and co-activators (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389354", "l": "Activation of Vav1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090655", "l": "double-stranded/single-stranded junction telomeric DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5679266", "l": "Beclin-1 complex translocates to the ER (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48435", "l": "ATP + N(6)-D-ribulosyl-L-lysyl-[protein] <=> ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028598", "l": "Phosphorylation of YAP by LATS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16885", "l": "2 bilirubin-glucuronoside = bilirubin IXalpha + bilirubin-bisglucuronoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163090", "l": "Elongation Of The Telomeric Chromosome End (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40840", "l": "FAD + H(+) + nonanoyl-CoA => (2E)-nonenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045301", "l": "tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050329", "l": "tetrahydroxypteridine cycloisomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28556", "l": "D-mannose + phosphate => D-mannose 6-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39838", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 1-(9Z-octadecenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43232", "l": "H2O + isatin = H(+) + isatinate"}, {"i": "EC:3.5.2.20", "l": "\"Isatin hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39484", "l": "3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209100", "l": "MYD88:TUB binds to TL receptor (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51160", "l": "cytidine(60) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(60) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400143", "l": "Fatty acid ligands activate PPARA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16950", "l": "myo-inositol + NAD(+) => H(+) + NADH + scyllo-inosose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676591", "l": "2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61947", "l": "24-methylenecholesterol + UDP-alpha-D-glucose <=> 24-methylene cholesteryl beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.99.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72107", "l": "Formation of the Spliceosomal E complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11118", "l": "an N-acetylalkane-alpha,omega-diamine + CoA + H(+) => acetyl-CoA + an alkane-alpha,omega-diamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34867", "l": "ATP + CoA + thiophene-2-carboxylate = AMP + diphosphate + thiophene-2-carbonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23227", "l": "trans-zeatin + UDP-alpha-D-glucose <=> H(+) + O-beta-D-glucosyl-trans-zeatin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10055", "l": "(R)-2-hydroxy-4-methylpentanoate + NAD(+) <=> 4-methyl-2-oxopentanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669023", "l": "TWEAK binds FN14 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2870221", "l": "E-selectin binds E-selectin ligand (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21765", "l": "heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047743", "l": "chlordecone reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731002", "l": "CLCN3 exchanges Cl- for H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51700", "l": "S-adenosyl-L-methionine + xanthogalenol = 4'-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30047", "l": "chloroacetaldehyde + H2O + NAD(+) = chloroacetate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33645", "l": "(9Z)-tetradecenoyl-CoA + AMP + diphosphate => (9Z)-tetradecenoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16977", "l": "acetoacetate + coenzyme M + NADP(+) = 2-oxopropyl-coenzyme M + CO2 + NADPH"}, {"i": "EC:1.8.1.5", "l": "\"2-oxopropyl-CoM reductase (carboxylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.n3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54527", "l": "acetoacetate + H(+) + methylglyoxal <=> 3-hydroxyhexane-2,5-dione + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090586", "l": "protein-phosphocysteine-N-acetylglucosamine phosphotransferase system transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54443", "l": "a (4S)-2,3-dehydroflavan-3,4-diol + H(+) <=> a 4-H-anthocyanidin with a 3-hydroxy group + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798282", "l": "TP53 and E2F4 bind the CDC25C gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16374", "l": "(R)-pantothenate + ATP => (R)-4'-phosphopantothenate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27427", "l": "(E)-beta-farnesene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139920", "l": "Translocation of tBID to mitochondria (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807826", "l": "LDHAL6B reduces PYR to LACT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20024", "l": "2-oxoglutarate + deoxyamidinoproclavaminate + O2 <=> amidinoproclavaminate + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32191", "l": "H2O + L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-oxoglutarate + 2 H(+) + NH4(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043737", "l": "deoxyribonuclease V activity"}, {"i": "MetaCyc:3.1.21.7-RXN"}, {"i": "EC:3.1.21.7", "l": "\"Deoxyribonuclease V\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43274", "l": "ganglioside GD2 + H(+) + UDP => ganglioside GD3 + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050445", "l": "asparagusate reductase activity"}, {"i": "RHEA:14881", "l": "3-sulfanyl-2-(sulfanylmethyl)propanoate + NAD(+) = asparagusate + H(+) + NADH"}, {"i": "EC:1.8.1.11", "l": "\"Asparagusate reductase\""}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0120294", "l": "peptide serotonyltransferase activity"}, {"i": "RHEA:66552", "l": "L-glutaminyl-[protein] + serotonin = 5-serotonyl-L-glutamyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24231", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+) <=> 4-methylcatechol + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354066", "l": "Translocation of PTK2 to Focal complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54711", "l": "N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55263", "l": "2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44504", "l": "4-hydroxybenzoate + an all-trans-polyprenyl diphosphate = a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate"}, {"i": "EC:2.5.1.39", "l": "\"4-hydroxybenzoate polyprenyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193753", "l": "3,7,24THCA-CoA is translocated from the cytosol to the peroxisome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31843", "l": "2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA = 2-oxepin-2(3H)-ylideneacetyl-CoA"}, {"i": "EC:5.3.3.18", "l": "\"2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1470009", "l": "Phosphorylation of STATs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49617", "l": "2-hydroxy-2-methylpropanal + H2O + NAD(+) => 2-hydroxy-2-methylpropanoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008967", "l": "phosphoglycolate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15957", "l": "D-altronate = 2-dehydro-3-deoxy-D-gluconate + H2O"}, {"i": "EC:4.2.1.7", "l": "\"Altronate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16134", "l": "H2O + N(1)-acetylspermine + O2 => 3-aminopropanal + H2O2 + N(1)-acetylspermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.7"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004487", "l": "methylenetetrahydrofolate dehydrogenase (NAD+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351894", "l": "Caspase mediated cleavage of BAP31 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683831", "l": "CCDC59 binds TTF1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088441", "l": "FOXM1 stimulates CENPF transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16899", "l": "a 3beta-hydroxysteroid ester + a diacylglycerol => a 3beta-hydroxysteroid + a triacylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34003", "l": "5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH + O2 = cholesta-5,7,24-trien-3beta-ol + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36496", "l": "alpha-D-glucose + ATP => ADP + alpha-D-glucose 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32523", "l": "nigerose + phosphate = beta-D-glucose 1-phosphate + D-glucose"}, {"i": "EC:2.4.1.279", "l": "\"Nigerose phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5323526", "l": "FRAT proteins bind GSK3beta (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070280", "l": "pyridoxal binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396599", "l": "Recruitment of GRB2:SOS to p-5Y-LAT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20508", "l": "an alpha-(gamma-L-glutamyl)-L-amino acid <=> 5-oxo-L-proline + an L-alpha-amino acid"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051741", "l": "2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17012", "l": "2-succinylbenzoate + ATP + CoA <=> 2-succinylbenzoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39363", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA = (2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41277", "l": "eicosanoate + sphing-4-enine => H2O + N-eicosanoyl-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174121", "l": "Association of Securin with Cdc20:APC/C complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158300", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668735", "l": "RAC1:GTP binds NOX3 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14922", "l": "(indol-3-yl)acetate + UDP-alpha-D-glucose => 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011300", "l": "ZSWIM8 ubiquitinates ROBO3.1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29599", "l": "monacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + monacolin J carboxylate + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.125", "l": "\"Monacolin L hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696274", "l": "RND1 binds GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209973", "l": "Tyrosine is diiodinated (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098639", "l": "collagen binding involved in cell-matrix adhesion"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8876789", "l": "CARNMT1 methylates CARN to Anserine (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57778", "l": "4-chloro-3-methylcatechol + NAD(+) + nitrite => 2-chloro-6-nitrotoluene + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28301", "l": "(2E,6E)-farnesyl diphosphate <=> (E)-gamma-bisabolene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418850", "l": "Activation of Cdc42 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56453", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole => 12-epi-hapalindole U"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686930", "l": "RIPK3 is cleaved by CASP8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0016748", "l": "succinyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193677", "l": "NRIF binds to p75NTR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23884", "l": "nicotinamide + S-adenosyl-L-methionine = 1-methylnicotinamide + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.1", "l": "\"Nicotinamide N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35293", "l": "3-oxoisopentadecanoyl-CoA + CO2 + CoA => 11-methyldodecanoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31851", "l": "(S)-2,3-epoxysqualene = parkeol"}, {"i": "EC:5.4.99.47", "l": "\"Parkeol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39189", "l": "(2E)-docosenoyl-CoA + H2O => (3R)-hydroxydocosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13580", "l": "a wax ester + H2O <=> a long chain fatty alcohol + a long-chain fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45427", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034914", "l": "trinitrophenol hydride denitratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20948", "l": "3-sulfopyruvate + H(+) = CO2 + sulfoacetaldehyde"}, {"i": "EC:4.1.1.79", "l": "\"Sulfopyruvate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13831", "l": "GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH => GDP-alpha-D-rhamnose + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033818", "l": "beta-ketoacyl-acyl-carrier-protein synthase III activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30055", "l": "L-allo-threonine + NADP(+) = (2S)-2-amino-3-oxobutanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668597", "l": "DNA polymerase:primase binds G-strand of the telomere (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40749", "l": "(3S)-3-hydroxy-L-lysine + CO2 + succinate => 2-oxoglutarate + L-lysine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43136", "l": "guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.215", "l": "\"tRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50510", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein] => acetyl-CoA + N-terminal L-valyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420688", "l": "GABAB heterodimeric receptor binds GABA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-178218", "l": "SMAD7:SMURF complex binds to phosphorylated TGFBR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22389", "l": "acetyl-CoA + N(6)-hydroxy-L-lysine => CoA + N(6)-acetyl-N(6)-hydroxy-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661217", "l": "MT1A binds zinc (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59320", "l": "D-cellobiono-1,5-lactone + H2O = 4-O-beta-D-glucopyranosyl-D-gluconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39607", "l": "(2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H(+) + NADPH = (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30271", "l": "2 (3,4-dimethoxyphenyl)methanol + H2O2 = 2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O"}, {"i": "RHEA:48004", "l": "1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 = 3,4-dimethoxybenzaldehyde + glycolaldehyde + guaiacol + H2O"}, {"i": "EC:1.11.1.14", "l": "\"Lignin peroxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448744", "l": "IL20RA binds IL20RB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25784", "l": "2-dehydro-3-deoxy-L-rhamnonate = (S)-lactaldehyde + pyruvate"}, {"i": "EC:4.1.2.53", "l": "\"2-keto-3-deoxy-L-rhamnonate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665727", "l": "FMNL2 binds CDC42:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102413", "l": "6-O-methyl-deacetylisoipecoside beta-glucosidase activity"}, {"i": "MetaCyc:RXN-13791"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033530", "l": "TYSND1 cleaves HSD17B4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22750", "l": "2 pyruvate => 4-hydroxy-4-methyl-2-oxoglutarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62215", "l": "3-hydroxybenzyl alcohol + O2 + reduced [NADPH--hemoprotein reductase] <=> gentisyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17816", "l": "D-altronate + NAD(+) <=> H(+) + keto-D-tagaturonate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451309", "l": "Edited Kainate Receptor binds glutamate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848975", "l": "PTK6 phosphorylates KHDRBS1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400382", "l": "CSNK1E,CSNK1D phosphorylate CRY and PER proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873919", "l": "Phosphorylation of JAK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19679", "l": "(3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin => 9'-cis-neoxanthin + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.22"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21558", "l": "[calmodulin]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-homocysteine => [calmodulin]-L-lysine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12971", "l": "an alcohol + H(+) + sn-glycerol 3-phosphate => a sn-glycero-3-phosphoester + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450975", "l": "isocitrate <=> citrate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158340", "l": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102582", "l": "cyanidin 3-O-p-coumaroylglucoside 2-O''-xylosyltransferase activity"}, {"i": "MetaCyc:RXN-15328"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21815", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35446", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-xylose <=> an anthocyanidin 3-O-beta-D-sambubioside + 2 H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24590", "l": "ADP + D-arabinose 5-phosphate + H(+) => ATP + D-arabinose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686625", "l": "LAIR1 binds collagen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2206299", "l": "Defective IDUA does not hydrolyse Heparan sulfate chain(6) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981814", "l": "GalNAc alpha-2,6-sialyltransferase II can add a sialic acid to the T antigen at the alpha 6 position (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54216", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15416", "l": "(2R,3R)-tartrate <=> H2O + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112434", "l": "Formation of DSIF complex  (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12228", "l": "ATP + H2O + L-aspartate + L-glutamine = AMP + diphosphate + H(+) + L-asparagine + L-glutamate"}, {"i": "EC:6.3.5.4", "l": "\"Asparagine synthase (glutamine-hydrolyzing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31248", "l": "H(+) + prop-2-ynal + pyrroloquinoline quinol => prop-2-yn-1-ol + pyrroloquinoline quinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62039", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O <=> a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004764", "l": "shikimate 3-dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682863", "l": "RNF168 binds DNA DSBs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52234", "l": "3 A + Fe(2+) + 3 H2O + mycobilin a => 3 AH2 + 2 H(+) + heme b + 3 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038106", "l": "choriogonadotropin hormone binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866321", "l": "VLDL binds APOC1 and APOC4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66644", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + trichobrasilenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59611", "l": "beta-alanyl-L-lysine + H2O <=> beta-alanine + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40927", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O = (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36747", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = beta-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}, {"i": "EC:2.4.1.303", "l": "\"UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol beta-1,3-galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938853", "l": "CDK6 binds RUNX1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443418", "l": "GP1b signaling involves c-Src (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43813", "l": "1,2-dioctadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42121", "l": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) => 5alpha-androstan-3,17-dione + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29629", "l": "alpha-maltoheptaose + beta-D-glucose => alpha-maltohexaose + beta-maltose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008316", "l": "structural constituent of vitelline membrane"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015416", "l": "ABC-type phosphonate transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623168", "l": "FOXO1,FOXO1:PPARGC1A,FOXO3,FOXO4,FOXO6 bind G6PC gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204169", "l": "PDP dephosphorylates p-lipo-PDH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20965", "l": "2-oxoglutarate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61817", "l": "16,17-didehydropregnenolone + UDP-alpha-D-glucose => 16,17-didehydropregnenolone 3-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032761", "l": "DOCK3 binds FYN associated with NTRK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983152", "l": "Transfer of ubiquitin from E1 to E2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018798", "l": "RHOV binds GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938217", "l": "RUNX1 binds the SWI/SNF complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56531", "l": "chloride + D-tryptophan + FADH2 + O2 <=> 6-chloro-D-tryptophan + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70596", "l": "GOT2 dimer deaminates L-Asp (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53127", "l": "all-trans-lycopene <=> delta-carotene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51012", "l": "a monoacyl-sn-glycero-3-phosphocholine + H2O = a monoacylglycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050318", "l": "tannase activity"}, {"i": "RHEA:16365", "l": "digallate + H2O = 2 3,4,5-trihydroxybenzoate + H(+)"}, {"i": "EC:3.1.1.20", "l": "\"Tannase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031831", "l": "type 5B serotonin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447246", "l": "IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430180", "l": "NCK recruits WASP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404142", "l": "atROL binds RBP1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400027", "l": "Gq alpha:G beta:G gamma dissociates to Gq alpha:GTP and G beta:G gamma (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007496", "l": "APAF1 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29312", "l": "FMNH2 + O2 + sulfoacetate => FMN + glyoxylate + 2 H(+) + H2O + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27494", "l": "S-adenosyl-L-methionine + tricetin => 3'-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0008469", "l": "histone-arginine N-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14099", "l": "L-phenylalanine + oxaloacetate => 3-phenylpyruvate + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12316", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}, {"i": "EC:3.1.3.64", "l": "\"Phosphatidylinositol-3-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61988", "l": "cytidine(72) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15314", "l": "ethanolamine => acetaldehyde + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.64", "l": "\"Caspase-11\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004315", "l": "3-oxoacyl-[acyl-carrier-protein] synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849102", "l": "SRMS phosphorylates PTK6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14958", "l": "H(+) + NADH + O2 + tetradecanoyl-CoA => (11Z)-tetradecenoyl-CoA + 2 H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42170", "l": "5beta-pregnan-3,20-dione + H(+) + NADPH => 20alpha-hydroxy-5beta-pregnan-3-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354073", "l": "Autophosphorylation of PTK2 at Y397 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549470", "l": "Expression of CRYPTOCHROME-2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18694", "l": "H2O + penicillin => 6-aminopenicillanate + a carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.89", "l": "\"4'-methoxyisoflavone 2'-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691004", "l": "XPC binds RAD23 and CETN2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240765", "l": "E2F1/2/3:DP1/2 binds EED gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55397", "l": "(R)-carnitine + H(+) + NADH + O2 => (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004132", "l": "dCMP deaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63761", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60863", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36682", "l": "dTDP-6-deoxy-alpha-D-allose + NAD(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5679205", "l": "ULK1 phosphorylates Beclin-1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12430", "l": "benzene-1,2,4-triol + NAD(+) => 2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62096", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683964", "l": "ATM phosphorylates EYA1-4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465924", "l": "OPN1LW binds 11cRAL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.2", "l": "\"Pyrroline-5-carboxylate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399941", "l": "AKT1 E17K mutant phosphorylates BAD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981610", "l": "Neuroglobin binds oxygen (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-171122", "l": "LDL + LDLR => LDL:LDLR complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29987", "l": "adenosine(in) + H(+)(in) = adenosine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45928", "l": "15-hydroxypentadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(16-hydroxy-2-oxohexadecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40291", "l": "ATP + CoA + tetradecanedioate = AMP + diphosphate + tetradecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429101", "l": "HMIT co-transports myo-inositol with a proton (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033720", "l": "(S)-mandelate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38688", "l": "(4R)-hydroxysphinganine(in) + ATP + H2O => (4R)-hydroxysphinganine(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848250", "l": "ACBD6 binds LCFA-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38305", "l": "2-dehydro-3-deoxy-6-phospho-D-gluconate + NH4(+) => 2-amino-2-deoxy-D-gluconate 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34725", "l": "15-methylhexadecasphing-4-enine + phosphate => 15-methylhexadecasphing-4-enine 1-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645598", "l": "RRAGC,D hydrolyzes GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612277", "l": "SPARC gene transcription is stimulated by ERBB4s80 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30323", "l": "all-trans-beta-carotene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62541", "l": "2 [Fe(II)cytochrome c] + 3 H(+) + ouabain => 2 [Fe(III)cytochrome c] + dihydroouabain"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-500708", "l": "GRIK3 homomer binds glutamate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24069", "l": "cyclohexanone + H(+) + NADPH + O2 => H2O + hexano-6-lactone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43369", "l": "dodecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(2-oxotridecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32053", "l": "adenosine 5'-tetraphosphate + AMP + 2 H(+) => H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13975", "l": "2 H(+)(out) + 2 phosphate => diphosphate + H(+)(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71303", "l": "RPE dimers isomerise RU5P to XY5P (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.52", "l": "\"Preflagellin peptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47292", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696266", "l": "RND2 binds effectors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68637", "l": "CDC6 protein is synthesized under the control of E2F transcription factors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59976", "l": "2-phenylacetate + H(+) = CO2 + toluene"}, {"i": "EC:4.1.1.119", "l": "\"Phenylacetate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1297333", "l": "Association of Acrosin Heavy and Light Chain (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56108", "l": "genistein + O2 + reduced [NADPH--hemoprotein reductase] = 2'-hydroxygenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39303", "l": "(3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA = (2E,11Z,14Z)-eicosatrienoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32572", "l": "(E)-2-methylgeranyl diphosphate + H2O => 2-methylisoborneol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9690449", "l": "S1PR1 bind S1P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551727", "l": "CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004921", "l": "interleukin-11 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20136", "l": "3-(indol-3-yl)lactate + NAD(+) <=> H(+) + indole-3-pyruvate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-874087", "l": "SGT1 binds HSP90 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2993802", "l": "HLCS biotinylates PC:Mn2+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45788", "l": "(9Z)-hexadecenoyl-CoA + 1,2-dihexadecanoyl-sn-glycerol = 1,2-dihexadecanoyl-3-(9Z-hexadecenoyl)-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10902", "l": "an aromatic oxo-acid + glycine => an aromatic L-alpha-amino acid + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18406", "l": "H2O + L-alanine + NAD(+) => H(+) + NADH + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12758", "l": "dihydrozeatin + NADP(+) => H(+) + NADPH + zeatin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351936", "l": "Caspase-mediated cleavage of claspin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418172", "l": "F2R binds ARRB2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621032", "l": "EGR1 binds the TPH1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66290", "l": "a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-D-mannosyl-alpha-1->6-inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052660", "l": "R-lactaldehyde reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44256", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57930", "l": "ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate => ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58672", "l": "D-glucuronate = aldehydo-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689972", "l": "USP2 deubiquitinates MDM2,MDM4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28089", "l": "2 H2O2 + Reactive Blue 5 <=> 2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H(+) + 2 H2O + phthalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879594", "l": "SLCO4C1 mediates the transport of digoxin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12121", "l": "alpha-D-glucose 1-phosphate + ATP + H(+) => ADP-alpha-D-glucose + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2691219", "l": "NOTCH1 HD domain mutants bind DLL1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0120227", "l": "acyl-CoA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665761", "l": "FMNL3 binds RHOC:GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192051", "l": "CYP7A1 7-hydroxylates CHOL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950292", "l": "Expression of Heterogeneous nuclear ribonucleoproteins A2/B1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18546", "l": "2-dehydro-3-deoxy-L-arabinonate => glycolaldehyde + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454208", "l": "Phosphorylation of beta and gamma subunits by LYN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23538", "l": "alpha-D-glucose 6-phosphate => alpha-D-glucose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203553", "l": "eNOS binds NOSIP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20298", "l": "an anilide + H2O => a carboxylate + aniline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46157", "l": "15,9'-di-cis-phytofluene + a plastoquinone => 9,9',15-tri-cis-zeta-carotene + a plastoquinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68826", "l": "Free CDT1 associates with CDC6:ORC:origin complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13217", "l": "H2O + NAD(+) + succinate semialdehyde = 2 H(+) + NADH + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53136", "l": "(3beta,5alpha,17beta)-3-hydroxy-androstan-17-yl sulfate + NADP(+) = 5alpha-dihydrotestosterone sulfate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60783", "l": "2-oxoglutarate + gibberellin A15 + O2 <=> CO2 + gibberellin A24 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166175", "l": "TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985594", "l": "MYO9B inactivates RHOA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204861", "l": "Interaction of Tie2 and Shc1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604664", "l": "ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28341", "l": "(R)-carnitinyl-CoA <=> crotonobetainyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50466", "l": "17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+) => 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) + 8 malonyl-CoA + 16 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021183", "l": "MECP2 mRNA translation is inhibited by miR-132 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12824", "l": "2-deoxy-D-ribose 5-phosphate <=> acetaldehyde + D-glyceraldehyde 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36515", "l": "H(+) + malonyl-CoA + tetracosanoyl-CoA = 3-oxohexacosanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38709", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20313", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)"}, {"i": "EC:2.7.1.158", "l": "\"Inositol-pentakisphosphate 2-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41811", "l": "(3R)-hydroxybutanoyl-[ACP] <=> (2E)-butenoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174916", "l": "Formation of N-glucuronides (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25722", "l": "H(+) + N,N-dihydroxy-L-trihomomethionine <=> (E)-6-(methylsulfanyl)hexanal oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12016", "l": "(2E,6E)-farnesyl diphosphate = (-)-germacrene D + diphosphate"}, {"i": "EC:4.2.3.75", "l": "\"(-)-germacrene D synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950731", "l": "CRLF1:IL27 translocates to the extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070410", "l": "co-SMAD binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012835", "l": "GDIs block activation of RHOA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663050", "l": "DHI and DHICA polymerise forming eumelanin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655193", "l": "KIAA0101 double monoubiquitination (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362422", "l": "Hh-Np binds to DISP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043395", "l": "heparan sulfate proteoglycan binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696547", "l": "STAMBPL1 is a deubiquitinase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23192", "l": "Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39473", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+) => (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799409", "l": "HIPK2 phosphorylates TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43662", "l": "ADP + H(+) + methylmalonyl-CoA + phosphate => ATP + hydrogencarbonate + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42578", "l": "2-methylpropanoate + 2-oxopent-4-enoate + H(+) => 2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41854", "l": "3-oxodecanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + malonyl-[ACP] + octanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950623", "l": "Expression of Carbonic anhydrase 1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47245", "l": "(2R)-3-phosphoglycerate + an NDP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11901", "l": "(1R,2S)-homoisocitrate + NAD(+) => 2-oxoadipate + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0032138", "l": "single base insertion or deletion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17072", "l": "all-trans-undecaprenyl diphosphate + H2O <=> all-trans-undecaprenyl phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5688797", "l": "ATXN3 family cleave Ub chains (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395320", "l": "Latent TGF-beta-1 binds integrins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48195", "l": "(9E)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,9E)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56493", "l": "hederagenin + O2 + reduced [NADPH--hemoprotein reductase] => gypsogenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.49", "l": "\"Hypodermin C\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67171", "l": "2-oxoglutarate + 3-hydroxy-L-phenylalanine <=> 3-(3-hydroxyphenyl)pyruvate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619783", "l": "CAMK1 phosphorylates ARHGEF7-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31919", "l": "indolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] = 3-hydroxyindolin-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.157", "l": "\"Indolin-2-one monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10935", "l": "ATP + L-aspartate + L-citrulline <=> 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807585", "l": "BPI binds LPS on the bacterial surface (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23224", "l": "trans-zeatin + UDP-alpha-D-glucose = H(+) + O-beta-D-glucosyl-trans-zeatin + UDP"}, {"i": "EC:2.4.1.203", "l": "\"Trans-zeatin O-beta-D-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246509", "l": "botC:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57710", "l": "4-O-(beta-D-glucosyl)-4-trans-coniferyl aldehyde + H(+) + UDP => (E)-coniferaldehyde + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38232", "l": "(9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA => 1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58326", "l": "cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine => beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044018", "l": "histone acetyltransferase activity (H3-K36 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196857", "l": "PANK2 phosphorylates PanK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36680", "l": "dTDP-6-deoxy-alpha-D-allose + NAD(+) => dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36492", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA => (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015486", "l": "glycoside-pentoside-hexuronide:cation symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621571", "l": "CD209 binds ICAM2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "73.344328060803463", "identifiers": [{"i": "GO:0042887", "l": "amide transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399931", "l": "Activation of Fyn (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69127", "l": "Formation of the Flap Intermediate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050565", "l": "aerobactin synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44803", "l": "1,4-dihydroxy-2-naphthoate + all-trans-hexaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-6 + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45272", "l": "12-phosphooxy-(9Z)-octadecenoate + H2O = 12-hydroxy-(9Z)-octadecenoate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37827", "l": "(S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 = 2,4-dichlorophenol + CO2 + pyruvate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24204", "l": "acetyl phosphate + H(+) + sulfite = phosphate + sulfoacetaldehyde"}, {"i": "EC:2.3.3.15", "l": "\"Sulfoacetaldehyde acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12345", "l": "(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) => H(+) + L-glutamyl-tRNA(Glu) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031873", "l": "type 2 proteinase activated receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46138", "l": "2 H2O + NADP(+) + pyrrolnitrin => aminopyrrolnitrin + H(+) + NADPH + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65851", "l": "A + a 3-oxo-Delta(1)-steroid + H2O <=> a steroid 1,3-dione + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2995334", "l": "COX15 transforms heme O to heme A (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13201", "l": "glycine + L-arginine = guanidinoacetate + L-ornithine"}, {"i": "EC:2.1.4.1", "l": "\"Glycine amidinotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35973", "l": "diphosphate + fumitremorgin B => 12alpha,13alpha-dihydroxyfumitremorgin C + dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15901", "l": "(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690886", "l": "ACO1, IREB2 bind IREs in TFRC, ALAD, FTL, FTH1 mRNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20572", "l": "H2O + L-arginine <=> L-ornithine + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49109", "l": "Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine => 3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + 2 H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49709", "l": "nocardicin G + S-adenosyl-L-methionine => H(+) + isonocardicin C + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804996", "l": "p14ARF sequesters MDM2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218821", "l": "PDK1 phosphorylates PKC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714483", "l": "RAC2 translocates to the ER membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801776", "l": "REG3A binds bacterial phospholipids (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36086", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-alkyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45565", "l": "2-epi-5-epi-valiolone => 5-epi-valiolone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675948", "l": "TNFRSF6B binds TNFSF6,14,15 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56605", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) => 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879909", "l": "Activation of STAT5a/b by JAK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60439", "l": "3-methylbutyl acetate + H2O <=> 3-methylbutanol + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54846", "l": "ethyl butanoate + H2O + NADP(+) => H(+) + hexan-3-one + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50158", "l": "N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018768", "l": "RHOU auto-activates (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34461", "l": "diphosphate + sclareol => 8-hydroxycopalyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601888", "l": "Unknown nuclease cleaves pre-piRNA in 4xMeR-PIWIL1:pre-piRNA:TDRD6:TDRKH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13279", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate => [L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.24"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33371", "l": "alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein] = alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein]"}, {"i": "EC:2.7.1.201", "l": "\"Protein-N(pi)-phosphohistidine--trehalose phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30695", "l": "3-aminopropanal + H2O + NAD(+) = beta-alanine + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948136", "l": "ULK1 Translocates to the mitochondria (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45999", "l": "a D-alpha-amino acid + a quinone + H2O <=> a 2-oxocarboxylate + a quinol + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32543", "l": "(2E)-geranyl diphosphate + H2O = 1,8-cineole + diphosphate"}, {"i": "EC:4.2.3.108", "l": "\"1,8-cineole synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38893", "l": "hexadecanoate + sphing-4-enine => H2O + N-hexadecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654422", "l": "Activated FGFR4 binds FRS2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37433", "l": "2 5'-deoxyadenosine + 2 A + 2 acetate + Fe-coproporphyrin III + 2 H(+) + 2 L-methionine => 12,18-didecarboxysiroheme + 2 AH2 + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352961", "l": "dihydroxyacetone phosphate + glyceraldehyde 3-phosphate <=> fructose 1,6-bisphosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9737780", "l": "MTTP binds lomitapide (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16011", "l": "ADP + formyl phosphate => ATP + formate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624130", "l": "Myristoylated NPHP3 translocates into the ciliary membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60292", "l": "L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.356", "l": "\"[Histone H3]-lysine(27) N-trimethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "78.819800280251172", "identifiers": [{"i": "GO:0090482", "l": "vitamin transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672158", "l": "GRB2:SOS1 complex binds to PDGFRA extracellular domain dimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2855047", "l": "Hydrolysis of internal thioester in C4b (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1449687", "l": "Corticosteroids bind to CBG in blood (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61857", "l": "dehydroprobetaenone I + 3 H(+) + 3 NADPH + 3 O2 => betaenone C + 3 H2O + 3 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050599", "l": "deacetoxycephalosporin-C synthase activity"}, {"i": "KEGG.REACTION:R05301"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54106", "l": "H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45419", "l": "11-oxo-5Z,9,12E,14E-prostatetraenoate + H2O <=> 15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851866", "l": "MET binds RANBP10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050692", "l": "DNA binding domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55426", "l": "(3E)-4,8-dimethylnona-1,3,7-triene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (3S,6E)-nerolidol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55350", "l": "9-cis-retinol => all-trans-retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22505", "l": "3'-phosphoadenylyl sulfate + quercetin 3-sulfate => adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3'-bissulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187506", "l": "Translocation of p27 to the nucleoplasm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61902", "l": "A + betaenone B => AH2 + betaenone C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849908", "l": "SALM4 binds flotillin-1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38474", "l": "L-histidine + 3 S-adenosyl-L-methionine <=> 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46940", "l": "AMP + diphosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] = ATP + holo-[LYS2 peptidyl-carrier protein] + L-2-aminoadipate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1458875", "l": "WNT binds to FZD and LRP5/6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389463", "l": "Proteinase-activated receptors can bind thrombin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905056", "l": "P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32302", "l": "2 (2E,6E)-farnesyl diphosphate + H(+) + NADH <=> 2 diphosphate + NAD(+) + squalene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54351", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline <=> 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11977", "l": "anhydrotetracycline + H(+) + NADPH + O2 => 5a,11a-dehydrotetracycline + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850831", "l": "KLK5 cleaves and activates KLK8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42112", "l": "(20S)-hydroxypregn-4-en-3-one + NADP(+) = H(+) + NADPH + progesterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391935", "l": "DP1 receptor can bind PGD2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022399", "l": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21594", "l": "H(+) + L-2-aminopentanoate + NADH + pyruvate => (2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983156", "l": "Polyubiquitination of substrate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296301", "l": "CCRL2 binds CCL19 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58662", "l": "a 5'-(5'-bisphosphomethyl)-ribonucleoside-RNA + S-adenosyl-L-homocysteine => a 5'-(5'-phosphomethyl)-ribonucleoside-RNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43922", "l": "(25R)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420117", "l": "VEGFR2 autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2032781", "l": "WWTR1 (TAZ) binds TEAD (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53876", "l": "a cytidine in tRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24557", "l": "5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+) => 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15639", "l": "[alginate](n+1) + GDP + H(+) => [alginate](n) + GDP-alpha-D-mannuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654569", "l": "Activated FGFR1 binds FRS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112271", "l": "The receptor:G-protein complex dissociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67072", "l": "a very long-chain fatty acyl-CoA + H2O = a very long-chain fatty acid + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63015", "l": "(2E,6E)-farnesyl diphosphate + orsellinate <=> diphosphate + ilicicolinate B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381109", "l": "IRE1 binds IRE1 forming dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810357", "l": "Fillagrin and keratin intermediate filaments polymerise forming a network (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111930", "l": "Adenylate cyclase produces cAMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009027", "l": "tartrate dehydrogenase activity"}, {"i": "RHEA:16457", "l": "(2R,3S)-tartrate + NAD(+) = 2-hydroxy-3-oxosuccinate + H(+) + NADH"}, {"i": "EC:1.1.1.93", "l": "\"Tartrate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22473", "l": "(R)-pantetheine + ATP => ADP + D-pantetheine 4'-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31209", "l": "(2E)-hexenoyl-CoA + FADH2 => FAD + H(+) + hexanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685319", "l": "CX3 complex formation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28875", "l": "H(+)(in) + L-tyrosine(in) = H(+)(out) + L-tyrosine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12796", "l": "1D-myo-inositol hexakisphosphate + ATP <=> 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912429", "l": "Resolution of meiotic holliday junction (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14126", "l": "2 raffinose => 1(F)-alpha-D-galactosylraffinose + sucrose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852331", "l": "GTSE1 translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16368", "l": "digallate + H2O <=> 2 3,4,5-trihydroxybenzoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201685", "l": "Beta-catenin is released from the destruction complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44283", "l": "2 H(+) + 2 malonyl-CoA + octadecanoyl-CoA <=> 4-hydroxy-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694528", "l": "Accessory proteins are recruited to the maturing virion (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31022", "l": "4 AH2 + all-trans-4,4'-diapolycopene + 4 O2 <=> 4 A + all-trans-4,4'-diapolycopene-4,4'-dial + 6 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944250", "l": "Association of procollagen type XXV (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29714", "l": "cadaverine(in) + H(+)(in) <=> cadaverine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043904", "l": "isochorismate pyruvate lyase activity"}, {"i": "RHEA:27874", "l": "isochorismate = pyruvate + salicylate"}, {"i": "EC:4.2.99.21", "l": "\"Isochorismate lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58029", "l": "5 (S)-methylmalonyl-CoA + a medium-chain fatty acyl-CoA + 32 H(+) + 5 malonyl-CoA + 22 NADPH => a mycoketide-CoA + 10 CO2 + 10 CoA + 11 H2O + 22 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57817", "l": "dGMP + H2O => 2-deoxy-D-ribose 5-phosphate + guanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034004", "l": "germacradienol synthase activity"}, {"i": "RHEA:22436", "l": "(2E,6E)-farnesyl diphosphate + H2O = (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate"}, {"i": "EC:4.2.3.22", "l": "\"Germacradienol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10997", "l": "2-methylpropanal oxime + S-adenosyl-L-methionine => 2-methylpropanal O-methyloxime + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32254", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+) <=> (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61763", "l": "rebaudioside B + UDP-alpha-D-glucose <=> rebaudioside A + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77081", "l": "Formation of the CE:GMP intermediate complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213207", "l": "Formation of collagen networks (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26238", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (2E,6E,10E)-geranylgeraniol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810724", "l": "PI3 binds the bacterial surface (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015657", "l": "branched-chain amino acid:sodium symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21522", "l": "2 [Fe(II)-cytochrome b1] + CO2 + H(+) => 2 [Fe(III)-cytochrome b1] + formate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047894", "l": "flavonol 3-sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56640", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0022889", "l": "serine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42386", "l": "4,4'-diaponeurosporenoate + 2 H(+) + NADH => 4,4'-diaponeurosporenal + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250220", "l": "Homodimerization of ERBB4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8856525", "l": "ANGPTL8 binds ANGPTL3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788571", "l": "STAT1,STAT3,STAT6 bind IL13:IL13R type II (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669874", "l": "Sorafenib-resistant KIT mutants do not bind sorafenib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450088", "l": "GLUT1 tetramer binds 4xATP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37791", "l": "aclacinomycin A + O2 = aclacinomycin Y + H2O2"}, {"i": "EC:1.3.3.14", "l": "\"Aclacinomycin-A oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44775", "l": "2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + NADPH + O2 <=> 2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690669", "l": "CD22 binds itself to form homo-oligomers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25165", "l": "A + butanoyl-CoA => (2E)-butenoyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18725", "l": "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = acetyl-CoA + vanillin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32442", "l": "(+)-epi-isozizaene + 2 H(+) + 2 NADPH + 2 O2 <=> albaflavenone + 3 H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49430", "l": "CMP-5'-phosphonoformate + diphosphate => CTP + phosphonoformate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15119", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine => 3'-dephospho-CoA + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17812", "l": "Mg-protoporphyrin IX + S-adenosyl-L-methionine <=> Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34987", "l": "(S)-lactate(in) = (S)-lactate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31508", "l": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine => H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853391", "l": "GlcNAc (Man)5 translocates from cytosol to lysosomal lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41703", "l": "1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + glutarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2769015", "l": "NICD1 PEST domain mutants translocate from cytosol to nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034530", "l": "4-hydroxymethylsalicyaldehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13637", "l": "H(+) + methane + NADH + O2 = H2O + methanol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610723", "l": "GLI proteins bind SUFU (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809663", "l": "Formation of hair keratin fibres (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4411383", "l": "NLK phosphorylates TCF/LEF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50291", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44253", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18183", "l": "(S)-malate + CoA + H(+) => acetyl-CoA + glyoxylate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949413", "l": "HTMLYS translocates from the mitochondrial matrix to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19539", "l": "D-mannitol + phosphate => D-mannitol 1-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53689", "l": "2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O => (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047470", "l": "(1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30354", "l": "H(+) + NADH + O2 + pyrrole-2-carboxylate <=> 5-hydroxypyrrole-2-carboxylate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193702", "l": "Part of the ICD migrates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033751", "l": "linoleate 8R-lipoxygenase"}, {"i": "RHEA:22392", "l": "(9Z,12Z)-octadecadienoate + O2 = (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47460", "l": "3-oxo-(5Z-tetradecenoyl)-CoA + CoA = (3Z)-dodecenoyl-CoA + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36434", "l": "a purine 2'-deoxy-D-ribonucleoside + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051740", "l": "ethylene binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781922", "l": "USP13 binds UFD1L:SKP2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928641", "l": "PAK binds RAC and bPIX (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34643", "l": "2 S-adenosyl-L-methionine + squalene = 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + 2 H(+) + 2 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.262", "l": "\"Squalene methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694274", "l": "mRNA1 is translated to pp1ab (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52112", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683719", "l": "Spike protein forms a homotrimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199910", "l": "MSK1 activates ATF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56174", "l": "8-demethyl-8-formylriboflavin 5'-phosphate + H2O => FMN + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3296304", "l": "GPR31 is a receptor for 12(S)-HETE (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30676", "l": "tetrahymanol => H2O + squalene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35521", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ethanolamine => (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl) ethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47146", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209921", "l": "Monoiodinated tyrosine can be deiodinated (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47848", "l": "2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate"}, {"i": "EC:2.5.1.3", "l": "\"Thiamine phosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033702", "l": "(+)-trans-carveol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036239", "l": "taxoid 7beta-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111924", "l": "PKA catalytic subunit translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847537", "l": "RAB43:GTP binds USP8NL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627107", "l": "XIAP binds CASP7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27412", "l": "3 a menaquinone + protoporphyrinogen IX <=> 3 a menaquinol + protoporphyrin IX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27750", "l": "2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801109", "l": "CHM binds RGGT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865454", "l": "CBFB binds RUNX3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30466", "l": "(2Z,6Z)-farnesyl diphosphate <=> (+)-alpha-santalene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47714", "l": "cis-3-hydroxy-D-proline => trans-3-hydroxy-L-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34824", "l": "(E)-feruloyl-CoA + (E)-feruloylacetyl-CoA + H2O => CO2 + 2 CoA + curcumin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16342", "l": "(R)-5-phosphomevalonate + ATP => (R)-5-diphosphomevalonate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604763", "l": "Autocatalytic activation of MMP7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24384", "l": "ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)"}, {"i": "EC:6.3.5.1", "l": "\"NAD(+) synthase (glutamine-hydrolyzing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687465", "l": "MRN complex binds RBBP8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38506", "l": "1,3-diacyl-sn-glycerol + H2O <=> a 1-acyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13826", "l": "GDP-alpha-D-rhamnose + NAD(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392064", "l": "G alpha (z) inhibits adenylate cyclase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36256", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2 => (6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32751", "l": "choline(out) = choline(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619034", "l": "ACEIs translocate from ER lumen to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42127", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) <=> 3alpha-hydroxy-5alpha-androstan-17-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5333051", "l": "RPA1 binds HSF1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50409", "l": "1-(2-aminophenyl)decane-1,3-dione => 2-heptyl-4(1H)-quinolone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437932", "l": "p-Y348-SYK binds VAV family (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839080", "l": "Activated cytosolic FGFR1 fusions bind PIK3CA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848414", "l": "Activated PTK6 binds CDKN1B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031797", "l": "type 2 metabotropic GABA receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39158", "l": "(3R)-hydroxyoctadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36964", "l": "(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211224", "l": "Association of DFF40 with DFF45 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57549", "l": "(S)-beta-macrocarpene + O2 + reduced [NADPH--hemoprotein reductase] => [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698844", "l": "MLKL binds HSP90:CDC37 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32377", "l": "1-hydroxylimonen-2-one + H(+) + NADH => limonene-1,2-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43811", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32635", "l": "linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (6E)-8-oxolinalool + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.84", "l": "\"Linalool 8-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28193", "l": "2'-deoxyadenosine + H(+) + H2O <=> 2'-deoxyinosine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791156", "l": "Expression of TATDN2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15895", "l": "Co(2+) + sirohydrochlorin => Co-sirohydrochlorin + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002172", "l": "high-affinity IgM receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20172", "l": "H(+) + NADPH + O2 + tetradecanoyl-CoA <=> (11E)-tetradecenoyl-CoA + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928646", "l": "EPHAs bind EFNAs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043802", "l": "hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity"}, {"i": "RHEA:12544", "l": "2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine = 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate"}, {"i": "EC:6.3.5.9", "l": "\"Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34638", "l": "1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 <=> H2O + NADP(+) + pentalenolactone D"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27513", "l": "7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine <=> dehydro coenzyme F420-0 + GMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13784", "l": "an L-alpha-amino acid + H2O + O2 <=> a 2-oxocarboxylate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692146", "l": "Expression of DHH in testis differentiation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170149", "l": "Translocation of active Cdc25C to the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050016", "l": "kynurenine 7,8-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65965", "l": "ATP + H2O + taurocholate(out) => ADP + H(+) + phosphate + taurocholate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15086", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O => an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + N-acetyl-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372449", "l": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168412", "l": "MDP elicits a NOD2 response (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22354", "l": "cadaverine + CO2 => H(+) + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001851", "l": "complement component C3b binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605591", "l": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28894", "l": "H(+)(in) + putrescine(in) <=> H(+)(out) + putrescine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24115", "l": "2 glutathione + O2 <=> glutathione disulfide + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32574", "l": "(E)-2-methylgeranyl diphosphate + H2O <=> 2-methylisoborneol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17613", "l": "NAD(+) + scyllo-inositol = H(+) + NADH + scyllo-inosose"}, {"i": "EC:1.1.1.370", "l": "\"Scyllo-inositol 2-dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174690", "l": "TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31044", "l": "(S)-methylmalonate semialdehyde + H2O + NAD(+) => 2 H(+) + methylmalonate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810357", "l": "Fillagrin and keratin intermediate filaments polymerise forming a network (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48915", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1a <=> CMP + ganglioside GT1a + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23114", "l": "3-methylphenol + CO2 => 6-methylsalicylate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033230", "l": "ABC-type cysteine transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66370", "l": "4-methyl-5-oxo-octanedioyl-CoA + acetyl-CoA => 6-methyl-3,7-dioxodecanedioyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23295", "l": "ATP + L-lombricine <=> ADP + H(+) + N-phospho-L-lombricine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20886", "l": "3-hydroxypyruvate + H(+) + NADH + NH4(+) => H2O + L-serine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810357", "l": "Fillagrin and keratin intermediate filaments polymerise forming a network (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16692", "l": "D-glucose 6-phosphate + H2O <=> D-glucose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390649", "l": "CHRM1,3,5 bind acetylcholine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37071", "l": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine = 2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35530", "l": "H(+) + N-ethylmaleimide + NADH <=> N-ethylsuccinimide + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636304", "l": "Mce3E binds MAPK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63690", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "81.790986234327661", "identifiers": [{"i": "GO:0034062", "l": "5'-3' RNA polymerase activity"}, {"i": "REACT:R-HSA-5696807", "l": "TRNT1 polymerizes CCA at the 3' end of pre-tRNA (Homo sapiens)"}, {"i": "REACT:R-HSA-6786881", "l": "TRNT1 polymerizes CCA at the 3' end of pre-tRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694522", "l": "Inner coat assembly and cargo binding (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46422", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1358791", "l": "Phosphorylation of USP8 by P-AKT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25362", "l": "(3Z)-phycoerythrobilin + 2 oxidized 2[4Fe-4S]-[ferredoxin] <=> biliverdin IXalpha + 4 H(+) + 2 reduced 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83656", "l": "TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798474", "l": "S100A8:S100A9 binds Zn2+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70971", "l": "citrate <=> isocitrate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31697", "l": "(8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate => (9Z,12Z)-octadecadienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30222", "l": "dimethyl sulfoxide + H2O + NAD(+) <=> dimethyl sulfone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27825", "l": "hydrogen sulfide + O-acetyl-L-homoserine <=> acetate + L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669898", "l": "KIT mutants bind type I TKIs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34751", "l": "ATP + N-acyl-15-methylhexadecasphing-4-enine = ADP + H(+) + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30485", "l": "H(+) + H2O + N,N-dihydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39826", "l": "2 [Fe(II)-cytochrome b5] + eicosanoate + 2 H(+) + O2 <=> 2-hydroxyeicosanoate + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "78.423603998002051", "identifiers": [{"i": "GO:0019120", "l": "hydrolase activity, acting on acid halide bonds, in C-halide compounds"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49885", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052926", "l": "dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49678", "l": "H2O + L-methionyl(47)-(R)-S-oxide-[F-actin] + NADP(+) => H(+) + L-methionyl(47)-[F-actin] + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17556", "l": "ATP + guanidinoethyl methyl phosphate <=> ADP + H(+) + N'-phosphoguanidinoethyl methylphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5679205", "l": "ULK1 phosphorylates Beclin-1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10781", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) => 3-(4-hydroxyphenyl)pyruvate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20274", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51712", "l": "keto-D-tagatose 6-phosphate = keto-D-fructose 6-phosphate"}, {"i": "EC:5.1.3.40", "l": "\"D-tagatose 6-phosphate 4-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798743", "l": "Exocytosis of secretory granule membrane proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58112", "l": "1''-O-acetyl-ADP-alpha-D-ribose + H2O = acetate + ADP-D-ribose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111237", "l": "Formation of ADAR1 homodimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201669", "l": "Beta-catenin translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32797", "l": "ADP + H(+) + L-cysteine(in) + phosphate => ATP + H2O + L-cysteine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11587", "l": "L-ornithine <=> D-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51142", "l": "(10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E)-docosapentaenoate => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17407", "l": "H(+) + N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine => N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18376", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56136", "l": "2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O"}, {"i": "EC:1.11.1.7", "l": "\"Peroxidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090411", "l": "brassinosteroid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64416", "l": "D-xylofuranose + NADP(+) = D-xylono-1,4-lactone + H(+) + NADPH"}, {"i": "EC:1.1.1.424", "l": "\"D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,4-lactone-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205075", "l": "JNK phosphorylates BIM, BAD and other targets (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34982", "l": "H(+)(in) <=> H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64573", "l": "isopentenyl diphosphate + neryl diphosphate => (2Z,6Z)-farnesyl diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033848", "l": "N2-(2-carboxyethyl)arginine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34466", "l": "8-hydroxycopalyl diphosphate <=> cis-abienol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14334", "l": "a 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol => 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31053", "l": "4-methyl-3-oxopentanoate + H(+) + NADH + NH4(+) => (3R)-beta-leucine + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40203", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607043", "l": "factor VIIIa associates with cell membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59243", "l": "L-arginine + L-lysine <=> L-homoarginine + L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41353", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "70.373142106726959", "identifiers": [{"i": "GO:0008081", "l": "phosphoric diester hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58853", "l": "(6E)-8-oxogeraniol + NAD(+) => (6E)-8-oxogeranial + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23608", "l": "H(+) + H2O + N-isopropylammelide = cyanurate + isopropylamine"}, {"i": "EC:3.5.4.42", "l": "\"N-isopropylammelide isopropylaminohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64428", "l": "glycyl-L-proline(out) + H(+)(out) = glycyl-L-proline(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507870", "l": "Aquaporins passively transport water out of cells (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357904", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27869", "l": "(2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate + H2O <=> (R)-glycerate + alpha-D-mannose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-481007", "l": "Exocytosis of platelet alpha granule contents (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11433", "l": "S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside => 7-O-methylvitexin 2''-O-beta-L-rhamnoside + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.31"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24000", "l": "a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]"}, {"i": "RHEA:53428", "l": "a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]"}, {"i": "EC:2.1.1.63", "l": "\"Methylated-DNA--[protein]-cysteine S-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-571327", "l": "IRAK2 phosphorylation bound to the activated TLR7 (or TLR21) complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59397", "l": "L-leucine => D-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26032", "l": "2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3,3'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16099", "l": "acetate + H(+) + pyruvate => acetylpyruvate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "81.20444558259193", "identifiers": [{"i": "GO:0004953", "l": "icosanoid receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13599", "l": "agmatine + urea => 1,4-diguanidinobutane + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46206", "l": "androst-5-en-3beta,7alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => androst-5-en-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2090079", "l": "GLB1 hydrolyses linker chain(2) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38240", "l": "(9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA => 1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51116", "l": "guanosine(6) in tRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.256", "l": "\"tRNA (guanine(6)-N(2))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12185", "l": "(S,S)-butane-2,3-diol + NAD(+) => (S)-acetoin + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190141", "l": "ALAD binds to Pb2+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10097", "l": "a fatty acyl-[ACP] + S-adenosyl-L-methionine => an N-acyl-L-homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32850", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycerol <=> a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1980044", "l": "NOTCH1 binds JAG2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034521", "l": "1-naphthoic acid dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209828", "l": "Tryptophan is hydroxylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64992", "l": "acetyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-acetyl-4'-phosphopantetheine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4086216", "l": "Collagen type VII binds integrin alpha2beta1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003681", "l": "bent DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24565", "l": "a 3-oxo acid + succinyl-CoA => a 3-oxoacyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8867613", "l": "PICALM binds R-SNAREs (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102390", "l": "mycophenolic acid acyl-glucuronide esterase activity"}, {"i": "RHEA:34179", "l": "H2O + mycophenolic acid O-acyl-beta-D-glucuronide = D-glucuronate + H(+) + mycophenolate"}, {"i": "EC:3.1.1.93", "l": "\"Mycophenolic acid acyl-glucuronide esterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198813", "l": "GSTO dimers reduce DeHA to AscH- (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66056", "l": "indole-3-pyruvate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50719", "l": "dimethyl sulfone + FMNH2 + O2 <=> FMN + formaldehyde + 2 H(+) + H2O + methanesulfinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21803", "l": "all-trans-antheraxanthin + L-ascorbate <=> all-trans-zeaxanthin + H2O + L-dehydroascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357432", "l": "AXL binds SRC-1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39987", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11003", "l": "an N-carbamoyl-D-amino acid + 2 H(+) + H2O <=> a D-alpha-amino acid + CO2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862184", "l": "USP48 cleaves polyubiquitin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54524", "l": "acetoacetate + H(+) + methylglyoxal = 3-hydroxyhexane-2,5-dione + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21746", "l": "1-aminocyclopropane-1-carboxylate + H(+) + S-methyl-5'-thioadenosine => S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428127", "l": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33357", "l": "1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA => a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33177", "l": "4-hydroxyphenylacetate(out) => 4-hydroxyphenylacetate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19709", "l": "a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA"}, {"i": "EC:2.3.1.51", "l": "\"1-acylglycerol-3-phosphate O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46208", "l": "ATP + CoA + eicosanoate = AMP + diphosphate + eicosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807578", "l": "GNLY binds the bacterial cell surface in the phagosome (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12873", "l": "(R)-2-hydroxy-4-methylpentanoate + NADP(+) = 4-methyl-2-oxopentanoate + H(+) + NADPH"}, {"i": "RHEA:35735", "l": "a (2R)-2-hydroxycarboxylate + NADP(+) = a 2-oxocarboxylate + H(+) + NADPH"}, {"i": "EC:1.1.1.272", "l": "\"D-2-hydroxyacid dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13447", "l": "(R)-pantothenate + cysteamine => (R)-pantetheine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31363", "l": "NADP(+) + reduced coenzyme F420-(gamma-Glu)(n) = 2 H(+) + NADPH + oxidized coenzyme F420-(gamma-Glu)(n)"}, {"i": "EC:1.5.1.40", "l": "\"8-hydroxy-5-deazaflavin:NADPH oxidoreductase\""}, {"i": "EC:1.6.99.n1", "l": "\"NADPH dehydrogenase (coenzyme F420 dependent)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44811", "l": "1,4-dihydroxy-2-naphthoate + all-trans-decaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-10 + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15551", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O => S-methyl-5-thio-D-ribulose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30650", "l": "1D-myo-inositol 3-phosphate + CTP + H(+) <=> CDP-1L-myo-inositol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20923", "l": "2,4-dichlorophenol + H(+) + NADPH + O2 <=> 3,5-dichlorocatechol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30347", "l": "ATP + IDP = ADP + ITP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14193", "l": "3-hydroxybenzoate + AH2 + O2 = 2,3-dihydroxybenzoate + A + H2O"}, {"i": "EC:1.14.99.23", "l": "\"3-hydroxybenzoate 2-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4837364", "l": "Secretion of SOD3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9706393", "l": "RHOBTB3 binds ATP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12270", "l": "1-pyrroline + H2O + L-glutamate => 2-oxoglutarate + putrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-741411", "l": "CYLD deubiquitinates NEMO (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709317", "l": "CO binds to free ferrohemoglobin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61542", "l": "ent-kaur-16-en-19-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5220959", "l": "TDG excises 5-formylcytosine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9035227", "l": "TXN2 binds CysS248-MPST (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34663", "l": "20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + S-adenosyl-L-methionine = 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46323", "l": "3beta-hydroxy-chol-5-ene-24-oyl-CoA + A <=> 3beta-hydroxy-chol-5,22-dien-24-oyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019914", "l": "cyclin-dependent protein kinase activating kinase regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42910", "l": "5-methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(1939) in 23S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21273", "l": "ATP + glutathione + spermidine => ADP + glutathionylspermidine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685603", "l": "SAP and EAT2 binds SLAMF6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27890", "l": "3'-UMP + H2O = phosphate + uridine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24062", "l": "H(+) + H2O + N,N-dihydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202703", "l": "CD47 binds SIRP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58361", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 => (5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57475", "l": "(E)-4-coumarate + UDP-alpha-D-glucose <=> 1-O-(trans-4-coumaroyl)-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46950", "l": "N(7)-methyl-GTP + S-adenosyl-L-homocysteine => GTP + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.8", "l": "\"Ribonuclease V\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389348", "l": "Activation of Rac1 by pVav1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48297", "l": "H2O + prostaglandin E2 1-glyceryl ester => glycerol + H(+) + prostaglandin E2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871370", "l": "p-Y281,292-RUFY1 translocates from cytosol to early endosome membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25394", "l": "(3Z)-6-oxohex-3-enoyl-CoA + H2O + NADP(+) <=> cis-3,4-dehydroadipyl-CoA + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001139", "l": "RNA polymerase II complex recruiting activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696670", "l": "CHD1L is recruited to GG-NER site (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22772", "l": "L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O"}, {"i": "EC:4.2.1.68", "l": "\"L-fuconate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1013020", "l": "Activation of GIRK/Kir3 Channels (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2855047", "l": "Hydrolysis of internal thioester in C4b (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20071", "l": "H2O + phenylacetonitrile => (Z)-phenylacetaldehyde oxime"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40144", "l": "(9Z,12Z)-octadecadienoyl-CoA + H2O => (9Z,12Z)-octadecadienoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15028", "l": "S-adenosyl-L-methionine + xanthosine <=> 7-methylxanthosine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59028", "l": "(Z)-24-ethylidenelophenol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429698", "l": "PRKD1,2,3 phosphorylates COL4A3BP-2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029476", "l": "Role of myosins in phagosome formation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904593", "l": "prostaglandin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102956", "l": "UDP-glucose:sinapaldehyde 4-beta-D-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443439", "l": "c-Src binds Raf1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40456", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA => (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6791016", "l": "SFTPB binds itself (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213236", "l": "TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58594", "l": "1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63371", "l": "ATP + H2O + spermine(out) <=> ADP + H(+) + phosphate + spermine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174119", "l": "Free APC/C phosphorylated by Plk1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855232", "l": "RELN:VLDLR binds DAB1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19715", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102675", "l": "C4-methyltransferase activity"}, {"i": "MetaCyc:RXN-4208"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19483", "l": "3-oxoadipyl-CoA + CoA => acetyl-CoA + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26549", "l": "beta-alaninamide + H2O <=> beta-alanine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61893", "l": "a (2E,4Z)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45150", "l": "3-hydroxy-3-(methylsulfanyl)propanoyl-CoA => 3-(methylsulfanyl)acryloyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4167511", "l": "HLCS biotinylates ACACB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30904", "l": "demethylspheroidene + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + spheroidene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932334", "l": "KEAP1:CUL3:RBX1:NFE2L2 dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55694", "l": "1D-myo-inositol 1-phosphate + an N-acyl-sphingoid base + H(+) => an inositol-1-phosphoceramide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51424", "l": "a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018669", "l": "3-hydroxybenzoate 6-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17737", "l": "NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH"}, {"i": "EC:1.1.1.25", "l": "\"Shikimate dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25862", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+) => GTP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14159", "l": "diphosphate + phosphate => H2O + triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26005", "l": "D-arabinitol 1-phosphate + NAD(+) <=> D-xylulose 5-phosphate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14320", "l": "morphine + NAD(+) <=> H(+) + morphinone + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48527", "l": "ganglioside GP1c + H2O <=> ganglioside GQ1c + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004706", "l": "JUN kinase kinase kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28681", "l": "H(+) + S-adenosyl-L-homocysteine + ubiquinol-8 => 3-demethylubiquinol-8 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21028", "l": "acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5683792", "l": "p-T68-CHEK2 autophosphorylates (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-482772", "l": "Release of platelet cytosolic components (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20495", "l": "an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111264", "l": "Addition of nucleotides between position +11 and +30 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42978", "l": "2-aminoprop-2-enoate + indole => L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19161", "l": "2 2-aminophenol + O2 = 2 6-iminocyclohexa-2,4-dienone + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44900", "l": "D-galactono-1,4-lactone + H2O = D-galactonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.7", "l": "\"Asclepain\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41779", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)/18:0) <=> CMP + ganglioside GM2 (d18:1(4E)/18:0) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61419", "l": "(S)-8-oxocitronellyl enol <=> cis-trans-nepetalactol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51520", "l": "(S)-reticuline + S-adenosyl-L-methionine = (S)-tembetarine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56309", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] => 1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983158", "l": "Trimming of peptides in ER (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52137", "l": "guanosine-5'-diphospho-5'-(DNA) + H2O => GMP + 2 H(+) + phospho-5'-(DNA)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43901", "l": "dalpatein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O => beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalpatein + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25027", "l": "NH4(+) + S-methyl-5'-thioinosine => H(+) + H2O + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10162", "l": "H(+) + keto-L-sorbose + NADH => L-iditol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24619", "l": "17beta-estradiol + NADP(+) <=> estrone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43220", "l": "guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.242", "l": "\"16S rRNA (guanine(1516)-N(2))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22154", "l": "a ubiquinol + D-glucono-1,5-lactone => a ubiquinone + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33267", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + 2 H2O + meso-2,6-diaminoheptanedioate + NADP(+) = 2 (S)-2-amino-6-oxoheptanedioate + NADPH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174058", "l": "Degradation of multiubiquitinated Cdh1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44379", "l": "a 1-acyl-sn-glycero-3-phosphocholine(in) <=> a 1-acyl-sn-glycero-3-phosphocholine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783880", "l": "PIPOX oxidises PPCA to P6C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75856", "l": "Abortive Initiation Before Second Transition (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36927", "l": "(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805811", "l": "Release of SEPT4 from mitochondria (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11558", "l": "3-dehydrocarnitine + H(+) + NADH => (S)-carnitine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.99.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.n2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17250", "l": "2 Fe(2+) + 2 H2O + H2O2 => 6 H(+) + 2 iron(III) oxide-hydroxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689972", "l": "USP2 deubiquitinates MDM2,MDM4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11177", "l": "2-alpha-D-glucosyl-D-glucose + phosphate => beta-D-glucose 1-phosphate + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026493", "l": "p-Y516 of p-5Y-NTRK2 recruits SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20043", "l": "2 H(+) + malonate + NADPH => 3-oxopropanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.41"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168859", "l": "Binding of NS1 to cleavage and host polyadenylation specificity factor (CPSF) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990310", "l": "type-III dockerin domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55881", "l": "apo-[aequorin]--coelenterazine + O2 => [aequorin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35737", "l": "a 2-oxocarboxylate + H(+) + NADPH => a (2R)-2-hydroxycarboxylate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632671", "l": "CSNK1A1 binds SMO dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17698", "l": "pyridine + thiamine => 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158278", "l": "factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19322", "l": "N,N-dimethylaniline N-oxide => formaldehyde + N-methylaniline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48191", "l": "(9Z,12Z)-octadecadienoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198732", "l": "STAT3 activation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047805", "l": "cytidylate cyclase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63660", "l": "(S)-8-amino-7-oxononanoate + CO2 + L-lysyl-[protein] = (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204779", "l": "Interaction of Tie2 with Ang1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14160", "l": "H2O + triphosphate <=> diphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10183", "l": "(6S)-10-formyltetrahydrofolate + H2O + NADP(+) <=> (6S)-5,6,7,8-tetrahydrofolate + CO2 + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48569", "l": "3-chlorocatechol + O2 => (2E,4Z)-2-chloromuconate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.201"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53644", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-corvol ether B + diphosphate"}, {"i": "EC:4.2.3.163", "l": "\"(+)-corvol ether B synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45838", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351407", "l": "Association of MRE11 with RAD50 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40124", "l": "an omega-hydroxy fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-oxo fatty acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52225", "l": "3 AH2 + 3 H(+) + heme b + 3 O2 => 3 A + biliverdin delta + CO + Fe(2+) + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67122", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37711", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-(1Z)-alkenyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64283", "l": "(S)-1-phenylethylamine + pyruvate <=> acetophenone + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27972", "l": "alpha-D-glucose + beta-maltose => alpha-maltotriose + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140561", "l": "EGF-domain serine glucosyltransferase activity"}, {"i": "RHEA:58116", "l": "L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose = 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP"}, {"i": "EC:2.4.1.376", "l": "\"EGF-domain serine glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209177", "l": "ERF binds ETS2 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043811", "l": "phosphate:acyl-[acyl carrier protein] acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433488", "l": "Phosphorylation of SHP2 by SFKs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429860", "l": "DCP1-DCP2 complex decaps mRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203977", "l": "SAR1 Activation And Membrane Binding (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46587", "l": "1alpha-hydroxyvitamin D2 + O2 + reduced [NADPH--hemoprotein reductase] <=> 1alpha,25-dihydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41888", "l": "3-oxotetradecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55782", "l": "all-trans-5,6-epoxyretinoyl-1-O-(beta-D-glucuronate) + UDP => all-trans-5,6-epoxyretinoate + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46857", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH => 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806405", "l": "TP53 stimulates PMS2 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3769397", "l": "SOST binds LRP5/6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696482", "l": "CTF1 binds LIFR:JAKs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49677", "l": "H(+) + L-methionyl(47)-[F-actin] + NADPH + O2 => H2O + L-methionyl(47)-(R)-S-oxide-[F-actin] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50279", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (12S)-hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20673", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937814", "l": "RUNX3 translocates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139842", "l": "Binding of Syk tyrosine kinase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-156910", "l": "Formation of eEF1B complex (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45236", "l": "(25R)-3beta-hydroxy-5-cholesten-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxy-5-cholestenoate + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46277", "l": "(S)-malate + H(+) => (S)-lactate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786650", "l": "DDHD1,2 hydrolyse PA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65626", "l": "CoA + H(+) + N-hexadecanoylsphinga-(4E,8Z)-dienine => hexadecanoyl-CoA + sphinga-(4E,8Z)-dienine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47151", "l": "a ubiquinone + caffeine + H2O <=> 1,3,7-trimethylurate + a ubiquinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23972", "l": "(2E)-glutaconyl-CoA + H(+) + Na(+)(in) = (2E)-butenoyl-CoA + CO2 + Na(+)(out)"}, {"i": "EC:7.2.4.5", "l": "\"Glutaconyl-CoA decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980118", "l": "ARRB mediates NOTCH1 ubiquitination (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42980", "l": "L-tyrosine = 2-aminoprop-2-enoate + phenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.88", "l": "\"Non-reducing end beta-L-arabinopyranosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-445079", "l": "Phosphorylation of L1 by ERK (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49745", "l": "deoxyviolaceinate + H(+) + O2 => CO2 + deoxyviolacein + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102613", "l": "trimethyluric acid monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33944", "l": "H(+) + 2 L-arginine + 3 NADH + 4 O2 => 4 H2O + 2 L-citrulline + 3 NAD(+) + 2 nitric oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62269", "l": "(R)-2-hydroxy-3-methylbutyrate + NADP(+) => 3-methyl-2-oxobutanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36445", "l": "6,8-dimethyl-6,7-didehydroergoline + H2O => dihydrochanoclavine-I aldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67127", "l": "a hydroperoxide + L-cysteinyl-[protein] <=> an alcohol + S-hydroxy-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73757", "l": "Binding of RRN3 to RNA Polymerase I (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-164423", "l": "PhosphoChREBP (Thr 666)  is exported to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33370", "l": "D-glucose(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-glucose 6-phosphate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635854", "l": "GLI2,3 are degraded by the proteasome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050601", "l": "myristoyl-CoA 11-(Z) desaturase activity"}, {"i": "MetaCyc:1.14.99.32-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964619", "l": "PAK1 binds ARHGEF6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63793", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O => C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41225", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21970", "l": "3-dehydroquinate + phosphate => 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.47", "l": "\"N-acylsphingosine galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62461", "l": "3,4-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] => 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19875", "l": "3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate => 3beta-sulfooxy-androst-5-en-17-one + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694441", "l": "CSNK1D phosphorylates SEC23 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964274", "l": "G alpha (12) binds BTK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25729", "l": "H(+) + H2O + N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162657", "l": "Inactivation of Myt1 kinase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65092", "l": "asperaculane G + O2 + reduced [NADPH--hemoprotein reductase] = aculene D + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3204311", "l": "AOX1 oxidises PXL to PDXate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48389", "l": "alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose => alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33651", "l": "(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12404", "l": "D-glucose + UDP-alpha-D-galactose = H(+) + lactose + UDP"}, {"i": "EC:2.4.1.22", "l": "\"Lactose synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204549", "l": "Caveolin-1 binds Basigin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103002", "l": "16-hydroxypalmitate dehydrogenase activity"}, {"i": "MetaCyc:RXN-9802"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52287", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63943", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + N-(hexanoyl)sphing-4-enine + O2 <=> 2 [Fe(III)-cytochrome b5] + 2 H2O + N-hexanoyl-sphinga-4E,14Z-dienine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508292", "l": "SYK binds IL2RB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65387", "l": "a 5'-(N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O <=> (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14364", "l": "H2O + O2 + S-prenyl-L-cysteine <=> 3-methyl-2-butenal + H2O2 + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391168", "l": "SIRP gamma binds CD47 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420265", "l": "AMY1-3 bind IAPP(34-70) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30453", "l": "isomultiflorenol => (S)-2,3-epoxysqualene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449872", "l": "acetaldehyde [cytosolic] => acetaldehyde [mitochondrial] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632182", "l": "PRMT1 methylates ESRs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61522", "l": "3-tyramine + A + H2O => AH2 + dopamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199404", "l": "CD40L binds CD40 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-442749", "l": "CaMKK autophosphorylates in the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44336", "l": "an L-alpha-amino acid + ATP + L-arginine = ADP + H(+) + L-arginyl-L-alpha-amino acid + phosphate"}, {"i": "EC:6.3.2.48", "l": "\"L-arginine-specific L-amino acid ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62429", "l": "3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA => 3,4-dihydroxybenzaldehyde + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12747", "l": "a 4-hydroxyacid + H(+) => a 1,4-lactone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52785", "l": "2-sulfenohercynine + AH2 + H(+) => A + ergothioneine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59050", "l": "CO2 + putrescine => D-ornithine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47656", "l": "acetyl-CoA + L-methionine sulfone = CoA + H(+) + N-acetyl-L-methionine sulfone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928640", "l": "PAKs phosphorylate MLC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198714", "l": "ERK5 translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44374", "l": "Cr(3+) + 2 H(+) + 2 NAD(+) + superoxide => Cr(6+) + 2 NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201521", "l": "ALK autophosphorylation downstream of PTN and MDK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51643", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (11R)-hydroperoxy-(9Z,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211962", "l": "CYP4F11 16-hydroxylates 3OH-PALM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46109", "l": "(2E,6E,10E)-geranylgeraniol + H(+) + 2 NADPH + 2 O2 => (2E,6E,10E)-geranylgeranate + 3 H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65113", "l": "2-oxoglutarate + aculene D + O2 => aculene C + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52574", "l": "(2E)-butenoyl-CoA + H(+) + NADH => butanoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.-", "l": "\"With other acceptors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44972", "l": "(R)-carnitine + hexanoyl-CoA = CoA + O-hexanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37841", "l": "1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033849", "l": "chrysanthemyl diphosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51047", "l": "indole-3-pyruvate imine dimer <=> CO2 + NH4(+) + protodeoxyviolaceinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5632677", "l": "PTCH is internalized (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-532549", "l": "MPI isomerises Fru6P to Man6P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27411", "l": "3 a menaquinol + protoporphyrin IX => 3 a menaquinone + protoporphyrinogen IX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44989", "l": "(R)-carnitine + 2-methylpropanoyl-CoA => CoA + O-isobutanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944219", "l": "Association of procollagen type XVI (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12434", "l": "H(+) + tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-N(6)-(L-alanyl)-L-lysyl-D-alanyl-D-alanine => L-alanyl-tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51225", "l": "2 [Fe(III)cytochrome c] + S-sulfanyl-L-cysteinyl-[SoxY protein] + thiosulfate => 2 [Fe(II)cytochrome c] + 2 H(+) + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25664", "l": "alpha-pinene + diphosphate => (2E)-geranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56099", "l": "[protein]-C-terminal Gly-Gly + ATP + H(+) <=> [protein]-C-terminal Gly-Gly-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769397", "l": "SOST binds LRP5/6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.151"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62075", "l": "D-galactose 6-phosphate + NADP(+) <=> 6-phospho-D-galactono-1,5-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22279", "l": "2-oxoaldehyde + H2O + NAD(+) <=> a 2-oxocarboxylate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943279", "l": "GGT dimers hydrolyse GSH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875661", "l": "GGA3 associates with activated MET receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13687", "l": "5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH => 5alpha-cholest-7-en-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59412", "l": "2-oxosuccinamate + H2O = NH4(+) + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4331331", "l": "TP53 binds the PMAIP1 (NOXA) promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60911", "l": "a cytidine in tRNA + S-adenosyl-L-methionine <=> an N(3)-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56314", "l": "3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate => 3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.4.-", "l": "\"Linked to decarboxylation\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16827", "l": "ADP + H(+) + UMP => ATP + uridine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033780", "l": "taurochenodeoxycholate 6alpha-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13567", "l": "4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H(+) => 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11100", "l": "4-hydroxyhexan-3-one = 2 propanal"}, {"i": "EC:4.1.2.35", "l": "\"Propioin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706293", "l": "Active FLT3 binds to CBL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37443", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857686", "l": "FITM1, FITM2 bind TAGs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5628871", "l": "BRD7 promotes EP300-mediated acetylation of TP53 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015411", "l": "ABC-type taurine transporter transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49967", "l": "5,10-dihydrophenazine + O2 <=> H2O2 + phenazine"}]}
{"type": "biolink:MolecularActivity", "ic": "79.682896251205548", "identifiers": [{"i": "GO:0016634", "l": "oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3785711", "l": "Telomere shortening during replicative exhaustion (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373746", "l": "SEMA4D interacts with CD45 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46263", "l": "2 [Fe(II)-cytochrome b5] + an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 H(+) + O2 <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160915", "l": "Receptor-mediated uptake of HA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27394", "l": "2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 => dichlorochromopyrrolate + H(+) + 2 H2O + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35428", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside => cyanidin 3,5-di-O-beta-D-glucoside + E-sinapate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46413", "l": "a (7Z,10Z)-hexadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a (7Z,10Z,13Z)-hexadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848250", "l": "ACBD6 binds LCFA-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201790", "l": "DARPP-32 is dephosphorylated on Thr75 by PP2A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36475", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA = (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-990489", "l": "Kinesin-13 is a dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9734730", "l": "ORC1 translocates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26253", "l": "H(+) + isopimara-7,15-dienol + NADPH + O2 = 2 H2O + isopimara-7,15-dienal + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38721", "l": "(R)-carnitine(in) + ADP + H(+) + phosphate => (R)-carnitine(out) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55668", "l": "11-cis-retinol--[retinol-binding protein] + NAD(+) = 11-cis-retinal--[retinol-binding protein] + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48745", "l": "(-)-yatein + 2-oxoglutarate + O2 => (-)-deoxypodophyllotoxin + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35400", "l": "1-O-(trans-4-coumaroyl)-beta-D-glucose + cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) betaine => beta-D-glucose + cyanidin 3-O-[6-O-(6-O-4-hydroxycinnamoyl-beta-D-glucosyl)-2-O-beta-D-xylosyl-beta-D-galactoside] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.27", "l": "\"Uracil-DNA glycosylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21538", "l": "H2O + trans-3-methylglutaconyl-CoA => (3S)-hydroxy-3-methylglutaryl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450074", "l": "Interleukin-3 receptor alpha subunit binds Interleukin-3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-947535", "l": "Cyclisation of GTP to precursor Z (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134946", "l": "DDX41 ubiquitination by TRIM21 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9604767", "l": "FLT3LG dimer:FLT3 dimer autophosphorylates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3296309", "l": "HCAR3 binds HCAR3 ligands (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26282", "l": "Co-precorrin-5A + H2O => acetaldehyde + Co-precorrin-5B + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52578", "l": "(2E)-hexenoyl-CoA + H(+) + NADH => hexanoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28095", "l": "di-trans,octa-cis-undecaprenyl diphosphate + H2O => di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52515", "l": "a quinone + trans-4-hydroxy-L-proline <=> (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373875", "l": "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675473", "l": "SH2B binds JAK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0005356", "l": "glucose:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943728", "l": "SALL4 binds the PTEN gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32563", "l": "(2E)-geranyl diphosphate = alpha-terpinene + diphosphate"}, {"i": "EC:4.2.3.115", "l": "\"Alpha-terpinene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013986", "l": "Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209107", "l": "Further phosphorylation of APC by DCO (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23219", "l": "benzoyl-CoA + H(+) + NADPH + O2 <=> 3-hydroxybenzoyl-CoA + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64090", "l": "3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 9 CO2 + 10 CoA + 2 H2O => acetyl-CoA + 9 H(+) + holo-[ACP] + 9 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604703", "l": "RUNX1 binds NOTCH4 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55182", "l": "2-hydroxy-3-methylnonanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methylnonanoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444647", "l": "C3a receptor binds anaphylatoxin C3a (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20386", "l": "(2R,3R)-dihydroquercetin + H(+) + NADH + O2 => (2R,3R)-2,3-dihydrogossypetin + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14642", "l": "cyanurate + H2O => biuret + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47457", "l": "(3S)-hydroxy-(5Z-tetradecenoyl)-CoA + NAD(+) => 3-oxo-(5Z-tetradecenoyl)-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20760", "l": "AH2 + linalool + O2 = (6E)-8-hydroxylinalool + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621399", "l": "SCD5 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9688838", "l": "RIPK3 binds STUB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60703", "l": "a 1-acyl-sn-glycero-3-phosphocholine <=> a 1-acyl-sn-glycero-2,3-cyclic phosphate + choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48196", "l": "H(+) + heptadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = reduced [electron-transfer flavoprotein] + trans-2-heptadecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.42"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33455", "l": "4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = CO2 + NADPH + zymosterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671707", "l": "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18583", "l": "glycolaldehyde + H2O2 + NH4(+) => ethanolamine + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211272", "l": "FOXOA2-, MAFA-, and PAX6-dependent synthesis of PDX1 protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50328", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102531", "l": "ecdysteroid-phosphate phosphatase activity"}, {"i": "RHEA:63576", "l": "ecdysone 22-phosphate + H2O = ecdysone + phosphate"}, {"i": "MetaCyc:RXN-14734"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30139", "l": "H2O + octadecanoyl-CoA = CoA + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662595", "l": "MT1E binds cadmium (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043135", "l": "5-phosphoribosyl 1-pyrophosphate pyrophosphatase activity"}, {"i": "MetaCyc:RXN-10969"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0032052", "l": "bile acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730884", "l": "Phosphorylation of NTAL by p-SYK/Lyn (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42719", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate <=> (2E)-thiogeraniol + 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635839", "l": "ULK3:SUFU dissociates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001735", "l": "prenylcysteine oxidase activity"}, {"i": "MetaCyc:1.8.3.5-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41477", "l": "5alpha-cholesta-8,24-dien-3beta-ol + an acyl-CoA => CoA + zymosterol ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32777", "l": "(2-aminoethyl)phosphonate(in) + ADP + H(+) + phosphate => (2-aminoethyl)phosphonate(out) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13902", "l": "H2O + N-(aminomethyl)urea => N-(hydroxymethyl)urea + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693243", "l": "RHOD translocates to the Golgi membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54404", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 2-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390025", "l": "Phosphorylated WTS autophosphorylates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653974", "l": "Ragulator binds Rag dimers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017983", "l": "MECP2 binds CRH gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050274", "l": "salicyl-alcohol beta-D-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62352", "l": "H(+) + NADPH + notoamide E + O2 = H2O + NADP(+) + notoamide D"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18941", "l": "a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+) = a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + H(+) + NADPH"}, {"i": "EC:1.1.1.413", "l": "\"A-factor type gamma-butyrolactone 1'-reductase (1S-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51363", "l": "H2O + N-(9Z-octadecenoyl)-L-leucine <=> (9Z)-octadecenoate + L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15290", "l": "[(1->4)-beta-D-xylan](n) + UDP-alpha-D-xylose => [(1->4)-beta-D-xylan](n+1) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733545", "l": "Bile salts and acids bind ALB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005359", "l": "low-affinity glucose:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-500717", "l": "Activation of GRIK3 homomer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9733973", "l": "Bile salts bind FABP6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985343", "l": "RUNX2 binds SOX9 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23419", "l": "(2R)-O-phospho-3-sulfolactate + H2O <=> (R)-3-sulfolactate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33417", "l": "[(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate + H(+) => bornane-2,6-dione + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54755", "l": "methanophenazine + reduced coenzyme F420-(gamma-Glu)(n) <=> dihydromethanophenazine + H(+) + oxidized coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106138", "l": "Sec61 translocon complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27910", "l": "D-gluconate + NAD(+) = 2-dehydro-D-gluconate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22814", "l": "5,10-methenyltetrahydrofolate + NADPH => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193705", "l": "IKKbeta phosphorylates IkB causing NF-kB to dissociate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28901", "l": "glycine(out) + H(+)(out) => glycine(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862280", "l": "FCHo proteins bind nascent clathrin-coated pit (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45402", "l": "(9Z)-octadecenoate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65361", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O => a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65551", "l": "ganglioside Fuc-GM1 + H2O <=> alpha-Fuc-(1->2)-beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-Glc + an N-acyl-sphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449087", "l": "CD4 binds Interleukin-16 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419351", "l": "PAF receptor binds platelet activating factor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114264", "l": "Translocation of activated BAX to the mitochondria (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14093", "l": "2-oxoglutarate + L-tryptophan = indole-3-pyruvate + L-glutamate"}, {"i": "EC:2.6.1.27", "l": "\"Tryptophan transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28965", "l": "H(+)(in) + L-proline(in) => H(+)(out) + L-proline(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-870269", "l": "Gastrin binds to CCK-B receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56055", "l": "2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> 2 alpha-D-mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31058", "l": "estrone 3-sulfate + H2O <=> estrone + H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44943", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + H2O <=> 1-O-alkyl-3-acyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604446", "l": "HES5 gene expression is stimulated by NOTCH4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173542", "l": "SMURF2 ubiquitinates SMAD2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17448", "l": "H2 + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362500", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798373", "l": "MDM2 ubiquitinates DYRK2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71849", "l": "LDH tetramer reduces PYR to LACT (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55923", "l": "[cis-1,4-isoprene](n) + O2 <=> (4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal + cis-1,4-isoprene(n-3)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50995", "l": "thromboxane B2(out) <=> thromboxane B2(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350168", "l": "LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40874", "l": "(9Z)-octadecenoyl-CoA + FAD + H(+) <=> (2E,9Z)-octadecadienoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46538", "l": "2 [Fe(III)-cytochrome b5] + a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-containing glycerolipid + 2 H2O => (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26037", "l": "3,8'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9606887", "l": "p-CD19:VAV binds PI3K and GRB2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592398", "l": "Activation of proMMP8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35068", "l": "(S)-carnitine(out) => (S)-carnitine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250264", "l": "TXNIP binds reduced thioredoxin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49210", "l": "20S,24S-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0032552", "l": "deoxyribonucleotide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10582", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n+1 + ADP + H(+) + phosphate => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + ATP + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028263", "l": "PGJ3 isomerises to δ12-PGJ3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928591", "l": "EPH:EFN tetramers oligomerise (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701549", "l": "AcK685-p-Y705,S727 STAT3 and SIN3A bind the PDRM1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28245", "l": "O2 + pratensein + reduced [NADPH--hemoprotein reductase] <=> 5-hydroxypseudobaptigenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11914", "l": "15-oxoprostaglandin E2 + H(+) + NADPH => 13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0003913", "l": "DNA photolyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48277", "l": "H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => a beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42835", "l": "(2E)-octenal + H(+) + pyruvate <=> (S)-3-acetyloctanal + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49841", "l": "(-)-dehydrodiconiferyl acid + 2 a quinone + H2O => (-)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106330", "l": "sialate 9-O-acetylesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:1990470", "l": "piRNA cluster binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64986", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149560", "l": "Unknown reductase reduces cob(II)alamin to cob(I)alamin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20912", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + taxa-4,11-diene"}, {"i": "EC:4.2.3.17", "l": "\"Taxadiene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35359", "l": "3-hydroxyisoheptadecanoyl-CoA = (2E)-15-methylhexadecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58633", "l": "N-tetradecanoyl-(2S)-hydroxyglycine => glyoxylate + tetradecamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21635", "l": "2 catechol + O2 <=> 2 1,2-benzoquinone + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109858", "l": "MAP2K2 binds MAPK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592362", "l": "Activation of proMMP7 by MMP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70482", "l": "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5228508", "l": "RANBP2 SUMOylates PML with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9021357", "l": "PRKCI phosphorylates ELF3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-984689", "l": "Kinesin-7 is a dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102055", "l": "12-hydroxyjasmonate sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49573", "l": "Fe-coproporphyrin III + 2 H(+) => coproporphyrin III + Fe(2+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374919", "l": "Noradrenaline clearance from the synaptic cleft (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10877", "l": "4-hydroxybenzoate + H(+) => CO2 + phenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112392", "l": "Resumption of elongation after recovery from pausing (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209566", "l": "TRAF6 is auto-ubiquitinated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41667", "l": "dihydrochelirubine + NAD(+) <=> chelirubine + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28721", "l": "adenine(out) + H(+)(out) => adenine(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34949", "l": "3-oxopropanoate + NH4(+) => (Z)-3-aminoacrylate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10508", "l": "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937419", "l": "CBR3 reduces DOX to DOXOL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55163", "l": "coenzyme B + coenzyme M + 2 oxidized [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981832", "l": "NMUR2 binds neuromedin-S (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848316", "l": "IL36 binds IL1RL2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57155", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 <=> (3S)-3-hydroxy-L-lysyl-[protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54628", "l": "2-oxoglutarate + dodecanoyl-CoA + O2 = 2-hydroxydodecanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58002", "l": "(20S)-ginsenoside Rg3 + H(+) + UDP => (20S)-ginsenoside Rh2 + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-182990", "l": "Sprouty sequesters CBL away from active EGFR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53636", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43861", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047963", "l": "glycine N-choloyltransferase activity"}, {"i": "RHEA:14001", "l": "choloyl-CoA + glycine = CoA + glycocholate + H(+)"}, {"i": "EC:2.3.1.65", "l": "\"Bile acid-CoA:amino acid N-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30136", "l": "dodecanoyl-CoA + H2O => CoA + dodecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40580", "l": "1-O-(1Z)-hexadecenyl-2 (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20876", "l": "(R)-2-benzylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein]"}, {"i": "EC:1.3.8.3", "l": "\"(R)-benzylsuccinyl-CoA dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730903", "l": "Oligomerization of TRAF6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29397", "l": "diphosphate + H(+) + UMP => H2O + UTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44992", "l": "(R)-carnitine + 2-methylbutanoyl-CoA = CoA + O-2-methylbutanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37351", "l": "cytidine 2'-phosphate + H2O = cytidine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418865", "l": "Recruitment of ABLIM to the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-500708", "l": "GRIK3 homomer binds glutamate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034909", "l": "6-hydroxypseudooxynicotine dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381091", "l": "IRE1 dimer autophosphorylates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.357", "l": "\"3-alpha-hydroxysteroid 3-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357445", "l": "PAK1-3 dimer disassociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051718", "l": "DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates"}, {"i": "REACT:R-HSA-5334151", "l": "DNMT1 methylates cytosine in hemimethylated DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0033892", "l": "deoxyribonuclease (pyrimidine dimer) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15383", "l": "2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO => O2 + quercetin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55940", "l": "all-trans-3,4-didehydroretinol + NAD(+) = all-trans-3,4-didehydroretinal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-114284", "l": "Release of Cytochrome c from mitochondria (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045569", "l": "TRAIL binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39576", "l": "3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111966", "l": "GRK2 binds CALM1:4Ca2+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026916", "l": "GGT hydrolyses RCTR2 to RCTR3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46256", "l": "2 [Fe(II)-cytochrome b5] + a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24688", "l": "formate + methanofuran => H2O + N-formylmethanofuran"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102455", "l": "anthocyanidin 3-O-glucoside 2''-O-glucosyltransferase activity"}, {"i": "RHEA:35419", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = an anthocyanidin 3-O-sophoroside + 2 H(+) + UDP"}, {"i": "EC:2.4.1.297", "l": "\"Anthocyanidin 3-O-glucoside 2''-O-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902248", "l": "5-O-phosphono-alpha-D-ribofuranosyl diphosphate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12810", "l": "4 catechol + 3 O2 => 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211983", "l": "CYP2J2 oxidises ARA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399952", "l": "Phosphorylation of LIMK-1 by PAK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39837", "l": "1-(9Z-octadecenoyl)-sn-glycerol + phosphate => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22351", "l": "4-aminoimidazole + H(+) + H2O <=> imidazol-4-one + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140346", "l": "phosphatidylserine flippase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114552", "l": "Thrombin-activated PARs activate G12/13 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000285", "l": "1-phosphatidylinositol-3-phosphate 5-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864737", "l": "TFAP2A homodimer binds the VEGFA gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41389", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55977", "l": "glutathione + thiosulfate => H(+) + S-sulfanylglutathione + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10439", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA <=> 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19769", "l": "phaseollidin hydrate = H2O + phaseollidin"}, {"i": "EC:4.2.1.97", "l": "\"Phaseollidin hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008966", "l": "phosphoglucosamine mutase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21462", "l": "2 benzaldehyde => benzoin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32380", "l": "(1R,2R,4S)-limonene-1,2-diol + NAD(+) => (1R,4S)-1-hydroxylimonen-2-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20555", "l": "(S)-methylmalonyl-CoA => (R)-methylmalonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706399", "l": "RHOBTB3 hydrolyzes ATP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.21", "l": "\"Coagulation factor VIIa\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55579", "l": "4-hydroxy-N-methyltryptamine 4-phosphate + S-adenosyl-L-methionine <=> H(+) + psilocybin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48456", "l": "1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = 2-octanoyl-3-O-beta-D-galactosyl-sn-glycerol + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22084", "l": "(S)-2,3-diaminopropanoate + H(+) + H2O = 2 NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380294", "l": "Loss of C-Nap-1 from centrosomes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810724", "l": "PI3 binds the bacterial surface (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37171", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53217", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha,17alpha-dihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13672", "l": "5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+) <=> 3-hydroxy-2-methylpyridine-5-carboxylate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603208", "l": "Defective OPLAH does not hydrolyse OPRO (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678327", "l": "MIOX oxidises Ins to GlcA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56410", "l": "1-(9Z-octadecaenoyl)-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626981", "l": "TNF-alpha:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28066", "l": "CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) = alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}, {"i": "EC:2.4.99.12", "l": "\"Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30167", "l": "D-erythrose 4-phosphate + dihydroxyacetone phosphate = sedoheptulose 1,7-bisphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63556", "l": "dynorphin A-(1-13) + H2O = dynorphin A-(1-12) + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64424", "l": "H(+)(out) + L-leucyl-L-proline(out) = H(+)(in) + L-leucyl-L-proline(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009010", "l": "sorbitol-6-phosphate 2-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47236", "l": "eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30925", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+) => (R)-glycerate + ADP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029272", "l": "Release of PLCG from FCGR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12589", "l": "ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GM2 (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071614", "l": "linoleic acid epoxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668831", "l": "CST complex formation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679045", "l": "C-ter TLR9 dimer binds HCQ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65854", "l": "a 1-hydroxy-3-oxo steroid => a 3-oxo-Delta(1)-steroid + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202947", "l": "Caspase mediated cleavage of APC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047613", "l": "aconitate decarboxylase activity"}, {"i": "KEGG.REACTION:R02243"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77081", "l": "Formation of the CE:GMP intermediate complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42996", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (R)-cembrene A + diphosphate"}, {"i": "EC:4.2.3.150", "l": "\"Cembrene A synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803411", "l": "PCBP4 modulates CDKN1A translation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693001", "l": "NAT8,8B acetylate BACE1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21705", "l": "H2O + L-tyrosine => NH4(+) + phenol + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913371", "l": "GM-CSF receptor alpha:GM-CSF binds Bc (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395364", "l": "LTBP4 binds TGF-Beta-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210426", "l": "Glutamate synaptic vesicle docking and priming (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6795460", "l": "SGK1 phosphorylates MDM2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044595", "l": "decaprenyldihydroxybenzoate methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25601", "l": "4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O = 2-(2-methylsulfanyl)ethylmalate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-984606", "l": "Kinesin-5 is a homotetramer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39486", "l": "3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850831", "l": "KLK5 cleaves and activates KLK8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805981", "l": "HMGB1 release from cells (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1564120", "l": "Collagen type VII degradation by MMP1,2,3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25841", "l": "5-deoxy-D-glucuronate => 5-dehydro-2-deoxy-D-gluconate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047519", "l": "quinate dehydrogenase (quinone) activity"}, {"i": "MetaCyc:1.1.99.25-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749098", "l": "ORC1 binds to DNA at origin of replication sites (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12588", "l": "ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GM2 (d18:1(4E)) + H(+) + UDP"}, {"i": "EC:2.4.1.92", "l": "\"(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051738", "l": "xanthophyll binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25498", "l": "(1S,5S)-beta-pinene + diphosphate => (2E)-geranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45077", "l": "(9Z,12Z)-octadecadienoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] => (9Z,12Z)-18-hydroxyoctadecadienoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.106", "l": "\"Hepsin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592278", "l": "Autocatalytic activation of proMMP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32679", "l": "(2E)-geranyl diphosphate + H2O = (2E)-geraniol + diphosphate"}, {"i": "EC:3.1.7.11", "l": "\"Geranyl diphosphate diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54932", "l": "(3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] = (2E,9Z)-hexadecadienoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54224", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphocholine = 2-(prostaglandin E2)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21279", "l": "D-arabinitol + NADP(+) <=> D-xylulose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28215", "l": "[thioredoxin]-dithiol + prostaglandin H2 => [thioredoxin]-disulfide + prostaglandin F2alpha"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26552", "l": "(S)-piperazine-2-carboxylate + NH4(+) => (S)-piperazine-2-carboxamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29897", "l": "ADP + H(+) + L-glutamine(in) + phosphate => ATP + H2O + L-glutamine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805109", "l": "CDK2 phosphorylates TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31652", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc + H2O => 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714483", "l": "RAC2 translocates to the ER membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0015616", "l": "DNA translocase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1299318", "l": "Activation of TASK (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690785", "l": "BAP1 binds Ub-HCFC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58918", "l": "(S)-2,3-epoxysqualene + 2 [Fe(III)-cytochrome b5] + H2O => 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + squalene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32213", "l": "(2E,4Z)-2-hydroxyhexa-2,4-dienedioate => (Z)-5-oxohex-2-enedioate"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0070259", "l": "tyrosyl-DNA phosphodiesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58308", "l": "25-substituted-cholesterol + beta-D-glucosyl-N-(15Z-tetracosenoyl)-sphing-4E-enine = 25-substituted-cholesteryl beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3785768", "l": "MRN complex binds DNA double strand breaks (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46942", "l": "ATP + holo-[LYS2 peptidyl-carrier protein] + L-2-aminoadipate => AMP + diphosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607751", "l": "TRAF6 oligomerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781905", "l": "ZRANB1 binds APC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210935", "l": "Furin cleaves ANTXR1-bound pagA to yield pagA(197-794) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40607", "l": "1-tetradecanoyl-sn-glycerol + H2O = glycerol + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022399", "l": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16139", "l": "3''-deamino-3''-oxonicotianamine + H(+) + NADPH => 2'-deoxymugineate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28871", "l": "D-fructuronate(in) + H(+)(in) = D-fructuronate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008860", "l": "ferredoxin-NAD+ reductase activity"}, {"i": "EC:1.18.1.3", "l": "\"Ferredoxin--NAD(+) reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665704", "l": "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604368", "l": "Autocatalytic activation of bound proMMP2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17070", "l": "all-trans-undecaprenyl diphosphate + H2O => all-trans-undecaprenyl phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1605591", "l": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692150", "l": "SOX9 binds the DHH gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848829", "l": "CBL autoubiquitinates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25687", "l": "H(+) + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys) => L-cysteinyl-tRNA(Cys) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.33", "l": "\"N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32568", "l": "(2E)-geranyl diphosphate => (1R,4S)-camphene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008806", "l": "carboxymethylenebutenolidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18623", "l": "a (2R,3R)-dihydroflavonol + CO2 + succinate => 2-oxoglutarate + a (2S)-flavan-4-one + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46186", "l": "3-methylbutanoyl-CoA + AMP + diphosphate => ATP + CoA + isovalerate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57612", "l": "20 H(+) + holo-[compactin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH = 9 CO2 + 9 CoA + dihydro-ML-236C-[compactin nonaketide synthase] + 6 H2O + 11 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25453", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + germacrene A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22371", "l": "L-ribulose 5-phosphate <=> D-xylulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18906", "l": "H2O + phosphonoacetaldehyde => acetaldehyde + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29241", "l": "H(+)(out) + uracil(out) => H(+)(in) + uracil(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051063", "l": "CDP reductase activity"}, {"i": "MetaCyc:CDPREDUCT-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40128", "l": "an omega-oxo fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => a dicarboxylate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37491", "l": "4-coumaroyl-CoA + S-adenosyl-L-methionine = CoA + H(+) + N-(4-coumaroyl)-L-homoserine lactone + S-methyl-5'-thioadenosine"}, {"i": "EC:2.3.1.229", "l": "\"4-coumaroyl-homoserine lactone synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30507", "l": "2-demethylmenaquinone-8 + H(+) + NADH = 2-demethylmenaquinol-8 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16891", "l": "6-acetamido-3-oxohexanoate + L-glutamate => 2-oxoglutarate + 6-acetamido-3-aminohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14181", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate"}, {"i": "EC:1.14.11.8", "l": "\"Trimethyllysine dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687388", "l": "SARS-CoV-1 gRNA:RTC:nascent RNA minus strand binds RTC inhibitors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38694", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418858", "l": "RhoGTPase GEF's recruited to DCC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21145", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) => 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953013", "l": "E2F7 binds E2F8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429441", "l": "SYK activation by SRC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432956", "l": "BP230 is recruited to the hemidesmosome (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15408", "l": "(3R)-3-hydroxybutanoyl-CoA + [(3R)-hydroxybutanoate](n) <=> [(3R)-hydroxybutanoate](n+1) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29247", "l": "3 H(+)(out) + 2 Na(+)(in) = 3 H(+)(in) + 2 Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61742", "l": "H(+) + steviolbioside + UDP => steviolmonoside + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65213", "l": "(2E)-dodecenoyl-CoA + H2O => (2E)-dodecenoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8957241", "l": "TP73 tetramer translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671772", "l": "p-T38-PPP1R14A binds MLCP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047377", "l": "5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29964", "l": "H(+)(in) + inosine(in) => H(+)(out) + inosine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54814", "l": "AMP + diphosphate + H(+) + L-isoleucine-(+)-7-isojasmonate => (+)-7-isojasmonate + ATP + L-isoleucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10001", "l": "H2O + pentanamide => NH4(+) + pentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76456", "l": "O-atom dealkylation of dextromethorphan (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26050", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] <=> glyceollin II + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59277", "l": "L-glutamine => D-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10701", "l": "H2O + limonene 1,2-epoxide => limonene-1,2-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10819", "l": "H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside <=> L-fucose + methyl beta-D-galactoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29008", "l": "H(+)(in) + Mn(2+)(in) => H(+)(out) + Mn(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51277", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196929", "l": "FLAD1 phosphorylates FMN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102082", "l": "demethylrebeccamycin--D-glucose O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12480", "l": "5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine"}, {"i": "EC:2.6.1.43", "l": "\"Aminolevulinate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23715", "l": "NADP(+) + pregnan-21-ol <=> H(+) + NADPH + pregnan-21-al"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029989", "l": "Autocatalytic phosphorylation of overexpressed FGFR2 variants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35628", "l": "delphinidin 3,5-bis-O-beta-D-glucoside + UDP-alpha-D-glucose => delphinidin 3,3',5-tri-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.55", "l": "\"E1 SAMP-activating enzyme\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60392", "l": "Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O = Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111883", "l": "Hydrolysis of phosphatidylcholine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733969", "l": "Bile salts dissociate from FABP6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54434", "l": "a 4-H-anthocyanidin with a 3-hydroxy group + CO2 + 2 H2O + succinate => 2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36773", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36040", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NAD(+) => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63776", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24283", "l": "myricetin + 2 S-adenosyl-L-methionine <=> 2 H(+) + 2 S-adenosyl-L-homocysteine + syringetin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5227009", "l": "ABCF1 binds EIF2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139898", "l": "Caspase-8 activates BID by cleavage (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64778", "l": "2-aminoprop-2-enoate + 3-sulfanyl-1-pentanol => 3-sulfanylpentan-1-ol-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0002020", "l": "protease binding"}, {"i": "REACT:R-HSA-1297354", "l": "Acrosin Cleavage (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027274", "l": "EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44672", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O = a 1-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086079", "l": "gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29030", "l": "2 H(+)(in) + L-glutamate(in) <=> 2 H(+)(out) + L-glutamate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114684", "l": "Phosphorylation of Syntaxin-4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784861", "l": "HSPG binds LPL dimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60011", "l": "a tRNA precursor + 2 CTP <=> a tRNA with a 3' CC end + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49124", "l": "H(+) + NADPH + O2 + protodeoxyviolaceinate = H2O + NADP(+) + protoviolaceinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3149539", "l": "MTR transfers CH3 group from MTHF to cob(I)alamin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62086", "l": "AMP + D-glucosamine 6-phosphate + H(+) => ADP + D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42571", "l": "2,3-dihydroxy-p-cumate + O2 <=> 3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196017", "l": "Dynamin is recruited to the gap junction plaque (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23728", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = A + H2O + prostaglandin H2"}, {"i": "EC:1.14.99.1", "l": "\"Prostaglandin-endoperoxide synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56256", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-threonyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47226", "l": "3beta-sulfooxy-16alpha-hydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3beta-sulfooxy-androst-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5691004", "l": "XPC binds RAD23 and CETN2 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694421", "l": "PP6 dephosphorylates SEC24 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177284", "l": "PKA phosphorylates PDE4B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20620", "l": "L-galactono-1,4-lactone + O2 <=> H(+) + H2O2 + L-ascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51827", "l": "ATP(in) + CoA(in) + H(+)(out) + octanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + octanoyl-CoA(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380508", "l": "Translocation of NuMA to the centrosomes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655235", "l": "Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71445", "l": "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38364", "l": "1-octadecanoylglycerol + H2O => glycerol + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5660980", "l": "p-S276-RELA binds RELB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17568", "l": "myo-inositol + S-adenosyl-L-methionine <=> 1D-1-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0072496", "l": "Pup transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60509", "l": "a guanosine in mRNA + S-adenosyl-L-methionine => an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201515", "l": "Active ALK recruits PI3K (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.39", "l": "\"Chymase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72160", "l": "Cleavage at the 3'-Splice Site and Exon Ligation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626228", "l": "The distal appendage proteins recruit TTBK2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50177", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 => N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma-aminobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52306", "l": "(2S)-2-acetamido-4-aminobutanoate => H2O + L-ectoine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14987", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9032798", "l": "DOCK3 activates RAC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-844447", "l": "NLRP1 senses MDP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0005384", "l": "manganese ion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40667", "l": "2-aminoprop-2-enoate = 2-iminopropanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40427", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38472", "l": "L-histidine + 3 S-adenosyl-L-methionine => 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167056", "l": "SHC binds to the activated TrkA receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791124", "l": "Expression of DNAJB9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0043891", "l": "glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity"}, {"i": "MetaCyc:GAPDHSYNEC-RXN"}, {"i": "EC:1.2.1.59", "l": "\"Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389348", "l": "Activation of Rac1 by pVav1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69140", "l": "RPA binds to the Flap (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38508", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645428", "l": "ALPK1 binds ADP-heptose (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990405", "l": "protein antigen binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661517", "l": "LUBAC comlex binds OTULIN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75096", "l": "Docking of the TAP:EJC Complex with the NPC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:1901513", "l": "lipo-chitin oligosaccharide transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-983150", "l": "Proteasomal cleavage of substrate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63040", "l": "H2O + lovastatin = H(+) + lovastatin carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12038", "l": "3-(imidazol-5-yl)pyruvate + H(+) + NADH => (S)-3-(imidazol-5-yl)lactate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57586", "l": "a 2-hydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a flavanone + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14874", "l": "indole-3-ethanol + NAD(+) => H(+) + indole-3-acetaldehyde + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34953", "l": "3-hydroxypropanoate(in) => 3-hydroxypropanoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3640862", "l": "Tankyrase binds AXIN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20577", "l": "3-hydroxyaminophenol = aminohydroquinone"}, {"i": "EC:5.4.4.3", "l": "\"3-(hydroxyamino)phenol mutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013006", "l": "RHOA:GTP translocates to the ER membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.32", "l": "\"Scytalidopepsin B\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2473594", "l": "Collagen type II degradation by MMP15 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28332", "l": "H(+) + IDP + phosphate => H2O + ITP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140696", "l": "factor V -> factor Va + factor V activation peptide (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.2.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202331", "l": "Recruitment of PLC-gamma1 to SLP-76 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31116", "l": "ATP + biotin + H(+) => biotinyl-5'-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013110", "l": "RHOC binds effectors at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696274", "l": "RND1 binds GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44474", "l": "1-O-alkyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine => 1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853793", "l": "p-5Y-RET complexes bind GRB2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54448", "l": "H2O + N-acyl-L-alpha-aminoacyl-tRNA = an N-acyl-L-amino acid + H(+) + tRNA"}, {"i": "EC:3.1.1.29", "l": "\"Aminoacyl-tRNA hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004803", "l": "transposase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202233", "l": "Inactivation of Lck by Csk (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60984", "l": "16-hydroxyhexadecanoate + NAD(+) = 16-oxohexadecanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54740", "l": "9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42570", "l": "3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+) => 2,3-dihydroxy-p-cumate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-421835", "l": "trans-Golgi Network Vesicle Scission (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53274", "l": "keto-D-tagaturonate => 5-dehydro-L-gluconate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39667", "l": "a secondary alcohol + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) = a ketone + reduced coenzyme F420-(gamma-Glu)(n)"}, {"i": "EC:1.1.98.5", "l": "\"Secondary-alcohol dehydrogenase (coenzyme-F420)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47465", "l": "(3E,5Z)-tetradecadienoyl-CoA => (2E,5Z)-tetradecadienoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036456", "l": "L-methionine-(S)-S-oxide reductase activity"}, {"i": "RHEA:19995", "l": "[thioredoxin]-dithiol + L-methionine (S)-S-oxide => [thioredoxin]-disulfide + H2O + L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051909", "l": "acetylenecarboxylate hydratase activity, producing 3-hydroxypropenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47371", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose <=> a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41873", "l": "3-oxododecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxydodecanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52195", "l": "(E)-phenylacetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] <=> (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36640", "l": "3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-methionine => 3-O-methylphospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705467", "l": "SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36618", "l": "2-hydroxyoctadecanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxyoctadecanoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45869", "l": "9-decenoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(non-8-en-1-yl)-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30028", "l": "D-glyceraldehyde + H(+) + NADH => glycerol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693761", "l": "FA2H hydroxylates CERA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952996", "l": "E2F7 forms homodimers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814153", "l": "ADO oxidises 2AET to HTAU (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173740", "l": "Factor B binds to C3(H2O) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2203480", "l": "COLEC11 binds ligands (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44441", "l": "a 1,3-diacylglycerol + a 1-acylglycerol => a triacylglycerol + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.140"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-532603", "l": "Nephrin mediated activation of N-WASP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39225", "l": "(2E)-octacosenoyl-CoA + H2O => (3R)-hydroxyoctacosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102803", "l": "thebane O-demethylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61396", "l": "ATP + N(6)-(D-erythrulosyl)-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938231", "l": "RUNX1:CBFB binds CREBBP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63303", "l": "N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63654", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "79.682896251205548", "identifiers": [{"i": "GO:0015296", "l": "anion:cation symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14906", "l": "5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate => 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62764", "l": "4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 = 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168886", "l": "Hemopexin binds Hemes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706312", "l": "Active FLT3 binds to LCK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102597", "l": "3alpha-hydroxy-ent-sandaracopimardiene 9-beta-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65242", "l": "(11Z)-octadecenoate + CoA + H(+) => (11Z)-octadecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46002", "l": "1-tuberculosinyladenosine + diphosphate => adenosine + H(+) + tuberculosinyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218812", "l": "FYN phosphorylates PAK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1606312", "l": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55151", "l": "a [(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP(+) <=> a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047260", "l": "alpha,alpha-trehalose-phosphate synthase (GDP-forming) activity"}, {"i": "MetaCyc:2.4.1.36-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60338", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009558", "l": "IL34 dimer binds SDC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59078", "l": "2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + 2 GDP + 2 H(+) => bis(myo-inositol) 1,3'-phosphate + 2 GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2993802", "l": "HLCS biotinylates PC:Mn2+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730840", "l": "Activation of RAC1 by VAV (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5628807", "l": "Defective SLC29A3 does not transport nucleosides from lysosomal lumen to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111916", "l": "Dimerization of p-S133-CREB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49160", "l": "1,4-cineole + O2 + reduced [NADPH--hemoprotein reductase] = 2-exo-hydroxy-1,4-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33406", "l": "ATP + L-threonine <=> diphosphate + L-threonyl-5'-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688797", "l": "ATXN3 family cleave Ub chains (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008904", "l": "hygromycin-B 7''-O-phosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12890", "l": "L-gulonate + NAD(+) => 3-dehydro-L-gulonate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234179", "l": "Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13948", "l": "(S)-mandelate <=> (R)-mandelate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60937", "l": "an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an (omega-1)-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675194", "l": "Activated MAPK phosphorylates RAF1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47046", "l": "acetoacetate + N,N,N-trimethylglycyl-CoA => 3-dehydrocarnitine + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50296", "l": "N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + O2 + reduced [NADPH--hemoprotein reductase] = 2-oxo-N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49331", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spheroidene <=> 2-hydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57414", "l": "ATP + H(+) + L-tyrosine + NADPH => AMP + diphosphate + L-tyrosinal + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25024", "l": "CTP + riboflavin <=> CDP + FMN + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188002", "l": "Rab5-mediated recruitment of class III PI3K to TLR9 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68826", "l": "Free CDT1 associates with CDC6:ORC:origin complexes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195378", "l": "Homodimerization of VEGF proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672973", "l": "MAP2Ks phosphorylate MAPKs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46967", "l": "lactate + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64069", "l": "(R)-phenylacetylcarbinol + NAD(+) => 1-phenyl-1,2-propanedione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51405", "l": "H2O + L-arginine + O2 => 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227893", "l": "TRAF3/or TRAF6 ubiquitination within dsRNA:MDA5:IPS1:TRAF3/TRAF6 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.156"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37227", "l": "(E,E)-sorbate + H(+) = (E)-1,3-pentadiene + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54643", "l": "(+)-copalyl diphosphate <=> (12E)-labda-8(17),12,14-triene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42360", "l": "D-allulose = keto-D-fructose"}, {"i": "EC:5.1.3.30", "l": "\"D-psicose 3-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64075", "l": "acetyl-CoA + 8 H(+) + holo-[ACP] + 8 malonyl-CoA <=> 3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 8 CO2 + 9 CoA + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28886", "l": "H(+)(in) + L-threonine(in) <=> H(+)(out) + L-threonine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-164617", "l": "Elongation of Extended Telomeric Chromosome End (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65694", "l": "a diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19900", "l": "H(+) + 2 L-arginine + 3 NADPH + 4 O2 <=> 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977371", "l": "Factor I inactivates Factor H-boundC3b (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199839", "l": "AKT can phosphorylate RSK (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63567", "l": "apelin-13 + H2O <=> apelin-12 + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38903", "l": "a sphingomyelin(in) + ATP + H2O = a sphingomyelin(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395364", "l": "LTBP4 binds TGF-Beta-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.28", "l": "\"Nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51776", "l": "4-prenylphlorisobutanophenone + dimethylallyl diphosphate = deoxycohumulone + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050509", "l": "N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56111", "l": "genistein + O2 + reduced [NADPH--hemoprotein reductase] <=> 2'-hydroxygenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37670", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52328", "l": "L-arginine + O2 + reduced [flavodoxin] = H(+) + H2O + N(omega)-hydroxy-L-arginine + oxidized [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047290", "l": "(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030408", "l": "glycine formimidoyltransferase activity"}, {"i": "MetaCyc:GLYCINE-FORMIMINOTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003743", "l": "translation initiation factor activity"}, {"i": "REACT:R-HSA-72697", "l": "Start codon recognition (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63460", "l": "(2E,6E,10E)-geranylgeraniol + GTP = (2E,6E,10E)-geranylgeranyl phosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047964", "l": "glyoxylate reductase (NAD+) activity"}, {"i": "RHEA:18229", "l": "glycolate + NAD(+) = glyoxylate + H(+) + NADH"}, {"i": "EC:1.1.1.26", "l": "\"Glyoxylate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47415", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102766", "l": "naringenin 7-O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37155", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42208", "l": "an omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+) + NADPH + O2 = an omega-(methylsulfinyl)-alkyl-glucosinolate + H2O + NADP(+)"}, {"i": "EC:1.14.13.237", "l": "\"Aliphatic glucosinolate S-oxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.12", "l": "\"Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.161", "l": "\"Beta-apiosyl-beta-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0031320", "l": "hexitol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061788", "l": "EGF repeat binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62413", "l": "(E)-feruloyl-CoA + H2O => acetyl-CoA + vanillin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47305", "l": "(9Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,9Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42466", "l": "2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + 2 H(+) => biphenyl-2,2',3-triol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34609", "l": "a 1,2-diacyl-sn-glycerol + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-15-methylhexadecasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38750", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-octadecenoyl) ethanolamine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70479", "l": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22345", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + (E)-caffeoyl-CoA => (R)-rosmarinate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51001", "l": "[fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine => [fructose-bisphosphate aldolase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42745", "l": "guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48083", "l": "abieta-8,11,13-triene + O2 + reduced [NADPH--hemoprotein reductase] <=> ferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097110", "l": "scaffold protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43184", "l": "S-adenosyl-L-methionine + uridine(2843) in 25S rRNA = H(+) + N(3)-methyluridine(2843) in 25S rRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.312", "l": "\"25S rRNA (uracil(2843)-N(3))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862380", "l": "HSD17B13 binds lipid droplets (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39954", "l": "(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59343", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene + A <=> 1'-hydroxy-demethylspheroidene + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43362", "l": "an N-acyl-beta-D-glucosyl-(1<->1')-sphinganine + H(+) + UDP => an N-acylsphinganine + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29518", "l": "beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46730", "l": "(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2 => (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25566", "l": "acetate + H(+) + N-acetylneuraminate => H2O + N-acetyl-4-O-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64555", "l": "(3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36821", "l": "3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoA => (11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451309", "l": "Edited Kainate Receptor binds glutamate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009885", "l": "transmembrane histidine kinase cytokinin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432909", "l": "Interaction of Plectin with Integrin beta 4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9668904", "l": "Formation of the CTF18 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684030", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17408", "l": "N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine <=> H(+) + N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42113", "l": "(20S)-hydroxypregn-4-en-3-one + NADP(+) => H(+) + NADPH + progesterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20888", "l": "3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)"}, {"i": "EC:3.1.2.4", "l": "\"3-hydroxyisobutyryl-CoA hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50867", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 <=> 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69127", "l": "Formation of the Flap Intermediate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33437", "l": "episterol => 24-methylene-5alpha-cholest-8-en-3beta-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49918", "l": "(R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out) => (R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682967", "l": "WHSC1 binds DNA DSBs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228407", "l": "tetX HC:LC binds target cell-surface gangliosides (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48174", "l": "N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetylneuraminate => ganglioside GM2 + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033726", "l": "aldehyde ferredoxin oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847968", "l": "PTEN binds FRK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59070", "l": "deoxyspectinabilin + S-adenosyl-L-homocysteine => demethyldeoxyspectinabilin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21424", "l": "3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH"}, {"i": "EC:1.1.1.238", "l": "\"12-beta-hydroxysteroid dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452515", "l": "Expression of STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655170", "l": "RCHY1 monoubiquitinates POLH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46728", "l": "(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2 = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28359", "l": "FAD + H(+) + tetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62572", "l": "H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteinylglycine = glycine + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1358789", "l": "Self-ubiquitination of RNF41 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035374", "l": "chondroitin sulfate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218806", "l": "FYN autophosphorylates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.239", "l": "\"3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928639", "l": "p-EFNB binds GRB4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052618", "l": "coenzyme F420-0:L-glutamate ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34041", "l": "6'-oxoparomamine + L-glutamate => 2-oxoglutarate + neamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20721", "l": "H2O + isopenicillin N + phenylacetyl-CoA => CoA + H(+) + L-2-aminoadipate + penicillin G"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75238", "l": "TRAIL binds TRAIL receptors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613460", "l": "ID1 and ID3 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49392", "l": "20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,23,24-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50646", "l": "3-(3-methylsulfanyl)propylmalate => 2-(3-methylsulfanyl)propylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55169", "l": "[TtuB sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) => [TtuB sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050446", "l": "azobenzene reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43810", "l": "1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.8.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35883", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507868", "l": "Aquaporins passively transport water into cells (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19143", "l": "11-cis-retinol => all-trans-retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22447", "l": "(E)-coniferol + NADP(+) <=> (E)-coniferaldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381290", "l": "PPARG:RXRA heterodimer binds to PPARG corepressors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.197"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11439", "l": "4 [Fe(II)cytochrome c] + 4 H(+) + O2 <=> 4 [Fe(III)cytochrome c] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58114", "l": "acetate + ADP-D-ribose + H(+) => 1''-O-acetyl-ADP-alpha-D-ribose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42941", "l": "cytidine(34) in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19464", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP <=> 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71303", "l": "RPE dimers isomerise RU5P to XY5P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53592", "l": "1-tetradecanoyl-sn-glycerol 3-phosphate + H2O = 1-tetradecanoyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352268", "l": "Cleavage of Satb1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16778", "l": "ATP + H2O + K(+)(out) => ADP + H(+) + K(+)(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070040", "l": "rRNA (adenine-C2-)-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5676229", "l": "WIPIs bind PI3P (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605591", "l": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31118", "l": "ATP + biotin + H(+) <=> biotinyl-5'-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44847", "l": "(R)-carnitine + eicosanoyl-CoA <=> CoA + O-eicosanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13508", "l": "choline + O2 <=> betaine aldehyde + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54200", "l": "N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354060", "l": "Translocation of RIAM to plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29268", "l": "L-valine(in) + Na(+)(in) => L-valine(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0031544", "l": "peptidyl-proline 3-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3857336", "l": "CEBPB homodimerization (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689861", "l": "Recruitment of XPA and release of CAK  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080072", "l": "spermidine:sinapoyl CoA N-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57717", "l": "hydrogencarbonate + NH4(+) => carbamate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60255", "l": "(S)-methylmalonyl-CoA + NADP(+) <=> acryloyl-CoA + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005525", "l": "GTP binding"}, {"i": "REACT:R-HSA-167429", "l": "The receptor:G-protein complex  binds GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956568", "l": "RUNX1 binds the core TAL1 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64862", "l": "(E)-sinapoyl-CoA + H(+) + S-adenosyl-L-homocysteine => (E)-5-hydroxyferuloyl-CoA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610726", "l": "The IFT-A complex recruits TULP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003755", "l": "peptidyl-prolyl cis-trans isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15939", "l": "an aldehyde + H(+) + NADPH => a primary alcohol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109700", "l": "AKT2 binds PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201608", "l": "Caspase-mediated cleavage of alpha adducin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30896", "l": "H2O + O2 + propane-1,3-diamine => 3-aminopropanal + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102244", "l": "3-aminopropanal dehydrogenase activity"}, {"i": "MetaCyc:RXN-12332"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14054", "l": "D-arabinose 5-phosphate + H2O + phosphoenolpyruvate => 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "75.324974028080362", "identifiers": [{"i": "GO:0016857", "l": "racemase and epimerase activity, acting on carbohydrates and derivatives"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1462014", "l": "Alpha-defensins form biologically active dimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50554", "l": "prostaglandin B1 => prostaglandin C1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39776", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 17,18-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050112", "l": "inositol 2-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12451", "l": "(R)-pantothenate + H2O <=> (R)-pantoate + beta-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9680443", "l": "ROCK1,2 bind ROCKi (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40412", "l": "1,2-dihexadecanoyl-sn-glycero-3-CDP + myo-inositol => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29892", "l": "ATP + H2O + L-histidine(out) => ADP + H(+) + L-histidine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961688", "l": "E2F1 binds the FBXO5 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32590", "l": "(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 <=> (3R,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30003", "l": "alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose = alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24826", "l": "dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40332", "l": "1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP => 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13549", "l": "beta-L-fucose 1-phosphate + GTP + H(+) = diphosphate + GDP-beta-L-fucose"}, {"i": "EC:2.7.7.30", "l": "\"Fucose-1-phosphate guanylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57316", "l": "ATP + cytidine 5'-diphosphoramidate = ADP + cytidine 3'-phospho-5'-diphosphoramidate + H(+)"}, {"i": "EC:2.7.1.224", "l": "\"Cytidine diphosphoramidate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43911", "l": "beta-D-galactosyl-(1<->1)-sphing-4-enine + H2O <=> D-galactose + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102348", "l": "trans-docosan-2-enoyl-CoA reductase activity"}, {"i": "MetaCyc:RXN-13307"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71445", "l": "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23271", "l": "guanidinoacetate + H2O <=> glycine + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22454", "l": "n H(+) + (n+1) phosphate => [phosphate](n+1) + n H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211224", "l": "Association of DFF40 with DFF45 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44950", "l": "1-O-alkyl-2-acyl-sn-glycerol + a fatty acid + H(+) => 1-O-alkyl-2,3-diacyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50038", "l": "adenosine 3',5'-bisphosphate + choloyl-4'-phosphopantetheine + 2 H(+) => choloyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186747", "l": "Ubiquitination of SKI/SKIL by RNF111/SMURF2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-453339", "l": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66434", "l": "H(+)(in) + L-galactose(in) => H(+)(out) + L-galactose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66795", "l": "N-methyl-D-dopa + O2 <=> (3R)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58879", "l": "4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432487", "l": "CWO binds to cwo gene and represses transcription (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38998", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O <=> a 1-acyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35165", "l": "H(+)(in) + minocycline(out) => H(+)(out) + minocycline(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3204311", "l": "AOX1 oxidises PXL to PDXate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654571", "l": "Activated FGFR1 binds FRS3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211951", "l": "CYP1B1 4-hydroxylates EST17b (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030380", "l": "interleukin-17E receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139909", "l": "Translocation of BMF to mitochondria (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016595", "l": "glutamate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683774", "l": "p-T68-CHEK2 dimerizes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54995", "l": "3 A + FMN + H2O + L-glutamate + O2 <=> 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 3 AH2 + CO2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168886", "l": "Hemopexin binds Hemes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2484822", "l": "Kinetochore assembly (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72691", "l": "Formation of the 43S pre-initiation complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195378", "l": "Homodimerization of VEGF proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936000", "l": "RUNX1 binds the CLDN5 (Claudin-5) gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202245", "l": "Phosphorylation of TBSMs in LAT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44197", "l": "3-methylundecanoate + ATP + CoA => 3-methylundecanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53161", "l": "H2O + N-acyl-sn-glycero-3-phosphoethanolamine => an N-acylethanolamine + H(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110219", "l": "Cleavage of thymine by TDG glycosylase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26187", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H2O <=> 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12419", "l": "beta-alanyl-CoA <=> acryloyl-CoA + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390124", "l": "MATS binds to HPO dimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802926", "l": "Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27406", "l": "a ubiquinone + H2O + pyruvate => a ubiquinol + acetate + CO2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102543", "l": "epsilon-rhodomycinone methylesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174097", "l": "Association of Emi1 with Cdh1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205136", "l": "GTP-bound RAC contributes to JNK activation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26217", "l": "abieta-7,13-diene + O2 + reduced [NADPH--hemoprotein reductase] = abieta-7,13-dien-18-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.144", "l": "\"Abieta-7,13-diene hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18222", "l": "1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O => a 1-O-alkyl-2-acetyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655243", "l": "Activated FGFR3 mutants phosphorylate PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296043", "l": "Activation of HCN channels (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878056", "l": "RUNX1:CBFB binds EP300 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25677", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605736", "l": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12768", "l": "CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate <=> acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5618107", "l": "ATP binding to HSP90 triggers conformation change (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102797", "l": "geranial:oxygen oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37543", "l": "2-amino-5-chlorophenol + O2 = 2-amino-5-chloromuconate 6-semialdehyde"}, {"i": "EC:1.13.11.76", "l": "\"2-amino-5-chlorophenol 1,6-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10127", "l": "H(+) + NADPH + O2 + phenylacetone <=> benzyl acetate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50273", "l": "(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => resolvin E1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51177", "l": "cytidine(48) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(48) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853800", "l": "ARTN binds RET:GFRA1,GFRA3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-606349", "l": "Mis18 complex binds the centromere (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209245", "l": "Tyrosine kinase Hopscotch (HOP) binds to the transmembrane cytokine receptor Domeless (DOME) to form the HOP:DOME complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55042", "l": "3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP] => (9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12608", "l": "D-glyceraldehyde 3-phosphate + H(+) + pyruvate <=> 1-deoxy-D-xylulose 5-phosphate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70420", "l": "HK1,2,3,GCK phosphorylate Glc to form G6P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004161", "l": "dimethylallyltranstransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877345", "l": "IL2 gene expression is stimulated by RUNX1 and NFATC2 and repressed by FOXP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801675", "l": "PLK2 phosphorylates NPM1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30072", "l": "acetyl-CoA + butanoate => acetate + butanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12515", "l": "D-aspartate + H2O + O2 <=> H2O2 + NH4(+) + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858428", "l": "FCAMR binds IgA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44398", "l": "1-heptadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA => 1-heptadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507875", "l": "Aquaporins passively transport urea into cells (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51088", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1471322", "l": "Beta-defensins are secreted (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58062", "l": "acetaldehyde + H(+) + sulfite => 2-sulfinoacetaldehyde + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952419", "l": "SMURFs ubiquitinate RUNX3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103050", "l": "isobutyraldehyde reductase activity"}, {"i": "MetaCyc:RXN0-7119"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163554", "l": "Phosphorylated HSL dimer translocates from the cytosol to the lipid particle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909726", "l": "Phosphorylation of STAT1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17536", "l": "2-oxoglutarate + an aromatic L-alpha-amino acid <=> an aromatic oxo-acid + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25874", "l": "H2O + pyridine N-oxide => H2O2 + pyridine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70613", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8979071", "l": "KDM6B binds iron (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110244", "l": "Excision of FapyG by OGG1 glycosylase (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30200", "l": "2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate => 2 ATP + benzoyl-CoA + 2 H2O + reduced 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8871226", "l": "RET binds GFRA1,GFRA2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106268", "l": "3,5-dichloro-THPH methyl transferase activity"}, {"i": "RHEA:48396", "l": "(3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine = 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350440", "l": "FT binds to DS in an adjacent cell (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948623", "l": "miR-20 microRNAs bind CNOT6L mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18188", "l": "adenosine + O2 <=> 5'-dehydroadenosine + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638137", "l": "EGFRvIII cancer variant does not bind EGF ligand (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015207", "l": "adenine transmembrane transporter activity"}, {"i": "REACT:R-HSA-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40467", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = (9Z)-octadecenoate + 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44912", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH = (3E)-hexenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63102", "l": "ascochlorin + 2 H2O + NADP(+) => H(+) + ilicicolin C + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191790", "l": "Loading and methylation of Sm proteins onto SMN Complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2870221", "l": "E-selectin binds E-selectin ligand (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13955", "l": "a D-alpha-amino acid + H(+) + tRNA => a D-aminoacyl-tRNA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36928", "l": "(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32848", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycerol => a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3225867", "l": "Expression of MINK1/TNIK is positively regulated by ROS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482773", "l": "MLCL transports from the IM to the ER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211960", "l": "CYP2U1 19-hydroxylates ARA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23610", "l": "cyanurate + isopropylamine => H(+) + H2O + N-isopropylammelide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57933", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655193", "l": "KIAA0101 double monoubiquitination (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14779", "l": "IMP + NH4(+) => AMP + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16408", "l": "benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) <=> benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25201", "l": "D-ribulose 5-phosphate + formaldehyde = D-arabino-hex-3-ulose 6-phosphate"}, {"i": "EC:4.1.2.43", "l": "\"3-hexulose-6-phosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.30"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031796", "l": "type 1 metabotropic GABA receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109860", "l": "MAP2K1 phosphorylates MAPK3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791095", "l": "Expression of HERPUD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55061", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] => a 12-oxojasmonyl-L-alpha-amino acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174963", "l": "NAT1 acetylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40152", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391941", "l": "BLT receptors can bind LTB4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56177", "l": "8-demethyl-8-formylriboflavin 5'-phosphate + A + H2O => 8-carboxy-8-demethylriboflavin 5'-phosphate + AH2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134800", "l": "STING dimerization (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036021", "l": "Defective MPDU1 does not promote transfer of Man to (GlcNAc)2 (Man)6 (PP-Dol)1 by ALG9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193669", "l": "TRAF6 binds to p75NTR:NRIF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57934", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-215526", "l": "CYP4F3 20-hydroxylates LTB4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193997", "l": "CYP11B1 oxidises 11DCORT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211193", "l": "Homodimerization  of DFF40 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682992", "l": "KDM4A,B bind H4K20Me2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16672", "l": "H2O + NAD(+) + xanthine <=> H(+) + NADH + urate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875183", "l": "CBL monoubiquitinates activated MET (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10915", "l": "(R)-pantoate + ATP + beta-alanine <=> (R)-pantothenate + AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578712", "l": "Importin-8 binds AGO2:miRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "69.188659142007225", "identifiers": [{"i": "GO:0016854", "l": "racemase and epimerase activity"}, {"i": "EC:5.1.-.-", "l": "\"Racemases and epimerases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33368", "l": "D-glucose(out) + N(pros)-phospho-L-histidyl-[protein] => D-glucose 6-phosphate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0097506", "l": "deaminated base DNA N-glycosylase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102563", "l": "aurachin C monooxygenase activity"}, {"i": "MetaCyc:RXN-15029"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42951", "l": "cytidine(48) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139919", "l": "Translocation of BIM to mitochondria (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22067", "l": "5alpha-ergosta-7,22-diene-3beta,5-diol <=> ergosterol + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0033840", "l": "NDP-glucose-starch glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25234", "l": "N-acetyl-alpha-neuraminate => N-acetyl-beta-neuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44572", "l": "4-hydroxy-3-all-trans-heptaprenylbenzoate + H(+) = 2-all-trans-heptaprenylphenol + CO2"}, {"i": "EC:4.1.1.98", "l": "\"4-hydroxy-3-polyprenylbenzoate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20247", "l": "3''-O-adenylylstreptomycin + diphosphate => ATP + streptomycin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5603467", "l": "Activated protein C is released from PROCR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25123", "l": "H(+) + H2O + L-1-piperideine-6-carboxylate => (S)-2-amino-6-oxohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649856", "l": "Oxidative damage to the AP site (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32083", "l": "CTP + pseudaminate = CMP-pseudaminate + diphosphate"}, {"i": "EC:2.7.7.81", "l": "\"Pseudaminic acid cytidylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183067", "l": "Localization of CBL:GRB2 to the membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675947", "l": "TNFSF18 binds TNFRSF18 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.1.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0003867", "l": "4-aminobutyrate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3364026", "l": "SET1 complex trimethylates H3K4 at the MYC gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40085", "l": "26-hydroxyhexacosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => hexacosanoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432946", "l": "PARVB/Affixin interacts with alpha PIX (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28368", "l": "beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosaminouronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189467", "l": "Cytosolic COPRO3 translocates to mitochondrial intermembrane space (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42652", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.314", "l": "\"Diphthine methyl ester synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2032770", "l": "Translocation of YAP1 to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209235", "l": "Phosphorylated BSK kinase transports from the cytosol to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.63", "l": "\"Beta-carotene 4-ketolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607725", "l": "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376419", "l": "Formation of NR-MED1 Coactivator Complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33623", "l": "ATP + CoA + dodecanoate = AMP + diphosphate + dodecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607751", "l": "TRAF6 oligomerizes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036190", "l": "indole-2-monooxygenase activity"}, {"i": "KEGG.REACTION:R07403"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052768", "l": "mannosyl-oligosaccharide 1,3-alpha-mannosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45566", "l": "5-epi-valiolone => 2-epi-5-epi-valiolone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204863", "l": "Interaction of Tie2 with Ang2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9674531", "l": "AAMP binds EGFR (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645428", "l": "ALPK1 binds ADP-heptose (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656219", "l": "Defective SLC4A4 does not cotransport Na+ with 3HCO3- (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23586", "l": "7,8-dihydrofolate + ADP + H(+) + phosphate => 7,8-dihydropteroate + ATP + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015130", "l": "mevalonate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46719", "l": "pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13040", "l": "ATP + H(+) + H2O <=> ITP + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216040", "l": "Collagen type IV networks bind integrins alpha1beta1, alpha2beta1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74986", "l": "Elongation of pre-rRNA transcript (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30088", "l": "(S)-2-hydroxyglutarate + FAD + H(+) => 2-oxoglutarate + FADH2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042781", "l": "3'-tRNA processing endoribonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12932", "l": "2-oxoglutarate + acetyl-CoA + H2O <=> (2R)-homocitrate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956031", "l": "NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168637", "l": "CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66130", "l": "(2S)-2-aminobutanoate + 3-phenylpyruvate => 2-oxobutanoate + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14440", "l": "H2O + L-lysine + O2 <=> 6-amino-2-oxohexanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15812", "l": "(2E)-geranyl diphosphate + H2O <=> (R)-linalool + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166538", "l": "The bound receptor dimerizes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004163", "l": "diphosphomevalonate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46581", "l": "O2 + reduced [NADPH--hemoprotein reductase] + vitamin D2 => 25-hydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65064", "l": "dimethylallyl diphosphate + siccayne = diphosphate + pestalodiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63123", "l": "(11Z)-eicosenamide + H2O <=> (11Z)-eicosenoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37006", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(13Z,16Z,19Z)-docosatrienoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56102", "l": "[small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate => [small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196857", "l": "PANK2 phosphorylates PanK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20153", "l": "ATP + L-arabinose = ADP + beta-L-arabinose 1-phosphate + H(+)"}, {"i": "EC:2.7.1.46", "l": "\"L-arabinokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176973", "l": "Association of MCM8 with ORC:origin complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31695", "l": "(9Z,12Z)-octadecadienoate + O2 = (8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate"}, {"i": "EC:1.13.11.62", "l": "\"Linoleate 10R-lipoxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39500", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA => (2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57290", "l": "a guanosine in RNA + H(+) + lactate => an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34770", "l": "5,10-methenyltetrahydrofolate + H2O <=> 5-formyltetrahydrofolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56438", "l": "2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684169", "l": "G6B binds PTPN6,PTPN11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36960", "l": "D-ribono-1,4-lactone + H(+) + NADH => D-ribose + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11554", "l": "1-O-alkyl-sn-glycerol + acetate + H(+) => a 1-O-alkyl-2-acetyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34742", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine <=> H(+) + N-acyl-15-methylhexadecasphing-4-enine + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11595", "l": "dihydromonacolin L-[lovastatin nonaketide synthase] + H2O <=> dihydromonacolin L carboxylate + H(+) + holo-[lovastatin nonaketide synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050825", "l": "ice binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22273", "l": "(20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase] => (20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265867", "l": "Formation of RPA-heterotrimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9688838", "l": "RIPK3 binds STUB1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164617", "l": "Elongation of Extended Telomeric Chromosome End (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56817", "l": "a pyrimidine ribonucleoside + H2O => a pyrimidine nucleobase + D-ribose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66836", "l": "4 O2 + preasperterpenoid A + 4 reduced [NADPH--hemoprotein reductase] = asperterpenoid A + 5 H(+) + 5 H2O + 4 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60854", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53658", "l": "(5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-eicosatetraenoate => (5S,6R)-dihydroxy-(7E,9E,11Z,14Z)-eicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28639", "l": "(2Z,6E)-farnesyl diphosphate = (-)-gamma-cadinene + diphosphate"}, {"i": "EC:4.2.3.62", "l": "\"(-)-gamma-cadinene synthase ((2Z,6E)-farnesyl diphosphate cyclizing)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102507", "l": "cyanidin 3-O-glucoside 7-O-glucosyltransferase (hydroxybenzoly-glucose dependent) activity"}, {"i": "MetaCyc:RXN-14434"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61370", "l": "4-methylumbelliferone sulfate(out) + ADP + H(+) + phosphate => 4-methylumbelliferone sulfate(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052604", "l": "delta-tocopherol cyclase activity"}, {"i": "MetaCyc:RXN-2561"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340124", "l": "CSN polymer binds CaPO4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213017", "l": "Auto-ubiquitination of TRAF3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865482", "l": "KMT2A (MLL) binds RUNX1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "73.946956196949927", "identifiers": [{"i": "GO:0030674", "l": "protein-macromolecule adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-427570", "l": "Group 3 - Selective Cl- transport (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63622", "l": "AMP + diphosphate + dodecanoyl-[ACP] => ATP + dodecanoate + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37616", "l": "(9Z)-octadecenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209944", "l": "25(OH)D binds GC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336182", "l": "GPR37 binds prosaptide (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689630", "l": "BAP1 binds BAP1-interacting complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008396", "l": "oxysterol 7-alpha-hydroxylase activity"}, {"i": "REACT:R-HSA-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9007447", "l": "E2F6 forms the PRC1L4 complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-350769", "l": "trans-Golgi Network Coat Activation (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804425", "l": "TP53 binds POU4F2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18713", "l": "2-oxoglutarate + UDP-N-acetylbacillosamine = L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-D-gluco-hex-4-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5656070", "l": "FGFBPs bind FGFs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-844438", "l": "NLRP1 oligomerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48002", "l": "H2O2 + NADP(+) => 1,6-dihydro-beta-NADP + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030297", "l": "transmembrane receptor protein tyrosine kinase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52666", "l": "a short-chain (2E)-enoyl-CoA + H2O => a short-chain (3S)-3-hydroxyacyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54519", "l": "8-hydroxycopalyl diphosphate <=> (13R)-manoyl oxide + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001691", "l": "pseudophosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684052", "l": "PIAS4 SUMOylates MDC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0017153", "l": "sodium:dicarboxylate symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55531", "l": "H(+) + H2O + L-tyrosine + O2 <=> (4-hydroxyphenyl)acetaldehyde + CO2 + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54702", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + H(+) => 4-hydroxybenzoyl-5'-AMP + holo-[4-hydroxyphenylalkanoate synthase]"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0001046", "l": "core promoter sequence-specific DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036004", "l": "GAF domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10474", "l": "propanoate + pyruvate => (2R,3S)-2,3-dimethylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32404", "l": "(1R,2S,4R)-neodihydrocarveol + NAD(+) => (1R,4R)-dihydrocarvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466832", "l": "Defective RDH5 does not oxidise 11cROL to 11cRAL and causes RPA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854303", "l": "TBC1D11 binds RAB6 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2509838", "l": "ITPA hydrolyses dITP to dIMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685607", "l": "Sialic acid binds SIGLEC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11172", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine"}, {"i": "EC:2.1.1.13", "l": "\"Methionine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10187", "l": "(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O <=> 3-oxoadipate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062101", "l": "peptidyl-aspartic acid 3-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34721", "l": "(2E)-13-methyltetradecenal + phosphoethanolamine => 15-methylhexadecasphing-4-enine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390302", "l": "tetracosenoyl-CoA + 8 O2 + 8 H2O + 8 NAD+ + 8 CoASH => octanoyl-CoA + 8 H2O2 + 8 NADH + 8 H+ + 8 acetyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59282", "l": "D-asparagine => L-asparagine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38202", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12574", "l": "adenosylcob(III)inamide + ADP + H(+) + phosphate => (R)-1-aminopropan-2-ol + adenosylcob(III)yrate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29097", "l": "4 H(+)(out) + NAD(+) + ubiquinol-8 => 5 H(+)(in) + NADH + ubiquinone-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8870469", "l": "RGGT geranylgeranylates RAB proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34109", "l": "1-deoxymethyl-3-dehydrosphinganine + CO2 + CoA => glycine + H(+) + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797100", "l": "CCNK binds CDK13 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25188", "l": "1,2-dichloroethane + H2O <=> 2-chloroethanol + chloride + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25354", "l": "H2O + L-cysteinyl-tRNA(Pro) <=> H(+) + L-cysteine + tRNA(Pro)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11531", "l": "2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29332", "l": "fumarate(in) + 2 H(+)(in) => fumarate(out) + 2 H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59125", "l": "(S)-2,3-diaminopropanoate + ATP + citrate => 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13913", "l": "L-threonine = D-threonine"}, {"i": "EC:5.1.1.6", "l": "\"Threonine racemase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33374", "l": "alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein] <=> alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904288", "l": "BAT3 complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52579", "l": "hexanoyl-CoA + NAD(+) <=> (2E)-hexenoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16884", "l": "hydrogen cyanide + thiosulfate <=> 2 H(+) + sulfite + thiocyanate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59536", "l": "ATP + butanoyl-CoA + hydrogencarbonate = (2R)-ethylmalonyl-CoA + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109860", "l": "MAP2K1 phosphorylates MAPK3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6813740", "l": "GDE1 hydrolyzes GroPIns (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53374", "l": "H(+) + NADH + uridine(17) in tRNA => 5,6-dihydrouridine(17) in tRNA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202144", "l": "Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62265", "l": "hydrogencarbonate(out) + selenite(out) + Zn(2+)(out) => hydrogencarbonate(in) + selenite(in) + Zn(2+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46351", "l": "(2E)-octenoyl-CoA + H2O <=> 3-hydroxyoctanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47617", "l": "ethionamide + H(+) + NADPH + O2 => ethionamide S-oxide + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042283", "l": "dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-5471"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042925", "l": "benzoate transmembrane transporter activity"}, {"i": "RHEA:32811", "l": "benzoate(in) = benzoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3786258", "l": "TP53 binds the CDKN1A promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30689", "l": "glyoxylate + pyruvate => (4R)-4-hydroxy-2-oxoglutarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000411", "l": "RANBP2 SUMOylates PML with SUMO2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34118", "l": "carboxynorspermidine + H2O + NADP(+) <=> H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44361", "l": "(2S)-2-hydroxy-3,4-dioxopentyl phosphate => 3-hydroxy-2,4-dioxopentyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21277", "l": "D-arabinitol + NADP(+) => D-xylulose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10696", "l": "a long-chain fatty acid + ATP + holo-[mycocerosate synthase] = AMP + diphosphate + long-chain fatty acyl-[mycocerosate synthase]"}, {"i": "EC:6.2.1.49", "l": "\"Long-chain fatty acid adenylyltransferase FadD28\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49858", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9690449", "l": "S1PR1 bind S1P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55187", "l": "2-oxoglutarate + 3-methylundecanoyl-CoA + O2 <=> 2-hydroxy-3-methylundecanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004816", "l": "asparagine-tRNA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1008200", "l": "NFE2 binds the beta globin locus control region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202727", "l": "Integrin alphaMbeta2 (MAC1) binds JAM3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36472", "l": "3,4,5-trihydroxybenzoate(out) + H(+)(out) => 3,4,5-trihydroxybenzoate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32947", "l": "a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA"}, {"i": "EC:2.3.1.22", "l": "\"2-acylglycerol O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54049", "l": "(2E,6E)-farnesyl diphosphate + H2O => 4-epi-cubebol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205289", "l": "Autophosphorylation of KIT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60268", "l": "N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43338", "l": "CO2 + N(6)-biotinyl-L-lysyl-[protein] + n Na(+)(out) => H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + n Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432067", "l": "Aquaporin-4 passively transports water out of cell (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21029", "l": "acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42629", "l": "S-adenosyl-L-methionine + uridine(747) in 23S rRNA => 5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15716", "l": "a beta-D-galactoside + acetyl-CoA <=> a 6-acetyl-beta-D-galactoside + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034070", "l": "aminoglycoside 1-N-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668218", "l": "NBEA binds DLG3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38312", "l": "carminomycin + S-adenosyl-L-methionine => daunorubicin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62435", "l": "a uridine in tRNA + S-adenosyl-L-methionine <=> a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102586", "l": "cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoyltransferase activity"}, {"i": "MetaCyc:RXN-15332"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58838", "l": "4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 24-methylenecycloartanol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45808", "l": "galactarate = (2S,3R)-dihydroxy-5-oxohexanedioate + H2O"}, {"i": "EC:4.2.1.158", "l": "\"Galactarate dehydratase (D-threo-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61093", "l": "H2O + N(2)-acetyl-L-citrulline => acetate + L-citrulline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.358", "l": "\"2-dehydropantolactone reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202713", "l": "CD84 homodimerises (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46033", "l": "H2O2 + tetradecanoate => (2S)-hydroxytetradecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19890", "l": "alpha-D-glucose 1-phosphate + H(+) + UTP => diphosphate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28996", "l": "H(+)(out) + L-threonine(in) => H(+)(in) + L-threonine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55839", "l": "calcitriol + UDP-alpha-D-glucuronate <=> calcitriol 25-O-(beta-D-glucuronide) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018756", "l": "RHOH binds GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53811", "l": "cholestanol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198714", "l": "ERK5 translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32998", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49200", "l": "D-mannose 6-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate"}, {"i": "EC:2.5.1.132", "l": "\"3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013652", "l": "NOTCH3 coactivator complex binds HES1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624949", "l": "Assembly of the anterograde IFT train (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51809", "l": "(9Z)-octadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) => (9Z)-octadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429698", "l": "PRKD1,2,3 phosphorylates COL4A3BP-2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2002428", "l": "Removal of fibrillar collagen N-propeptides (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0070026", "l": "nitric oxide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28444", "l": "dodecanoyl-(Kdo)2-lipid IVA + holo-[ACP] => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + dodecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014456", "l": "GDIs block activation of RHOG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30864", "l": "4-O-phospho-L-tyrosine + H2O => L-tyrosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0019888", "l": "protein phosphatase regulator activity"}, {"i": "REACT:R-HSA-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43157", "l": "guanosine(9) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29726", "l": "glyoxylate(in) <=> glyoxylate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53774", "l": "chenodeoxycholoyl-CoA + lithocholate => chenodeoxycholate + lithocholoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250978", "l": "botG LC cleaves target cell VAMP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34331", "l": "H(+) + indole-3-pyruvate + NADPH + O2 = (indol-3-yl)acetate + CO2 + H2O + NADP(+)"}, {"i": "EC:1.14.13.168", "l": "\"Indole-3-pyruvate monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1467466", "l": "ABCA4 mediates atRAL transport (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48410", "l": "adenosine 3',5'-bisphosphate + H(+) + holo-[EntF peptidyl-carrier protein] => apo-[EntF peptidyl-carrier protein] + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047965", "l": "glycoprotein O-fatty-acyltransferase activity"}, {"i": "MetaCyc:GLYCOPROTEIN-O-FATTY-ACYLTRANSFERASE-RXN"}, {"i": "EC:2.3.1.142", "l": "\"Glycoprotein O-fatty-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156661", "l": "Formation of Exon Junction Complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14035", "l": "1D-myo-inositol 1-phosphate + glycerol + H(+) => H2O + sn-glycero-3-phospho-1D-myo-inositol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22955", "l": "O2 + octanedioyl-CoA <=> (2E)-octenedioyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75862", "l": "Fall Back to Closed Pre-initiation Complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017077", "l": "oxidative phosphorylation uncoupler activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019785", "l": "ISG15-specific protease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51130", "l": "AH2 + an aldehyde + NH4(+) => A + an aliphatic amine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33905", "l": "4-oxo-4-(pyridin-3-yl)butanal + H2O2 + methylamine => H2O + O2 + pseudooxynicotine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42378", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638046", "l": "ACY3:Zn2+ dimer hydrolyses mercapturic acids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75820", "l": "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23615", "l": "1,2-dihydro-alpha-santonin + NAD(+) <=> alpha-santonin + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37762", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141159", "l": "TNF-mediated dimerization of procaspase-8 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64147", "l": "H2O + N-(9Z-octadecenoyl)-L-methionine <=> (9Z)-octadecenoate + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40135", "l": "(9Z)-tetradecenoyl-CoA + H2O = (9Z)-tetradecenoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031786", "l": "type 1B melatonin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44363", "l": "(2S)-2-hydroxy-3,4-dioxopentyl phosphate <=> 3-hydroxy-2,4-dioxopentyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177942", "l": "EGFR binds EGF ligand (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021596", "l": "Membrane estrogen receptors bind SRC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654159", "l": "Activated FGFR2 binds PLCG1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66221", "l": "asc-omegaC7-CoA + O2 => asc-omegaDeltaC7-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17263", "l": "a phenol + H(+) + sulfate => a phenyl sulfate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73577", "l": "CAD hexamer transforms L-Gln to CAP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210285", "l": "Trans-homophilic interaction of PECAM-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10595", "l": "a 3',5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 3'-hydroxy,5'-unsubstituted flavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12002", "l": "CO2 + NADPH => formate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682598", "l": "ATM phosphorylates HERC2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204813", "l": "Interaction of Tie2 and Grb14 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53945", "l": "2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+) => (2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351948", "l": "Mitochondrial recruitment of Drp1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000403", "l": "Y-form DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42663", "l": "NAD(+) + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + NADH + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417842", "l": "P2Y10 receptor can bind to LPA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008215", "l": "RUNX2 binds GLI3R (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3076905", "l": "Extracellular BTD hydrolyses BCTN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018586", "l": "mono-butyltin dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797554", "l": "ABP1 binds SHANK proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9017817", "l": "Gamma-secretase cleaves YBX1:NOTCH3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17316", "l": "ATP + L-histidine + tRNA(His) <=> AMP + diphosphate + H(+) + L-histidyl-tRNA(His)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645220", "l": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10485", "l": "H2O + N-feruloylglycine => (E)-ferulate + glycine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030374", "l": "nuclear receptor coactivator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42552", "l": "uridine(31) in tRNA = pseudouridine(31) in tRNA"}, {"i": "EC:5.4.99.42", "l": "\"tRNA pseudouridine(31) synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36989", "l": "alpha-D-ribose 1,5-bisphosphate + cytosine => CMP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814555", "l": "Integrator complex processes the 3' end of snRNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030736", "l": "phenol O-methyltransferase activity"}, {"i": "KEGG.REACTION:R01239"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55533", "l": "H(+) + H2O + L-phenylalanine + O2 => 2-phenylacetaldehyde + CO2 + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102506", "l": "cyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218836", "l": "PTK2beta binds alphaVbeta3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54268", "l": "2-oxoglutarate + L-asparaginyl-[hypoxia-inducible factor alpha subunit] + O2 = (3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha subunit] + CO2 + succinate"}, {"i": "EC:1.14.11.30", "l": "\"Hypoxia-inducible factor-asparagine dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45100", "l": "6-demethylmitomycin B + S-adenosyl-L-methionine = mitomycin B + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18057", "l": "O2 + Watasenia luciferin = CO2 + hnu + oxidized Watasenia luciferin"}, {"i": "EC:1.13.12.8", "l": "\"Watasenia-luciferin 2-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42280", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30218", "l": "a menaquinol + 2 nitric oxide <=> a menaquinone + H2O + nitrous oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54433", "l": "2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 => a 4-H-anthocyanidin with a 3-hydroxy group + CO2 + 2 H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0005201", "l": "extracellular matrix structural constituent"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47760", "l": "a uridine in 21S rRNA + S-adenosyl-L-methionine = a 2'-O-methyluridine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961620", "l": "E2F1 binds the CDC6 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18664", "l": "H2O + N(5)-[1(S)-1-carboxyethyl]-L-ornithine + NADP(+) <=> H(+) + L-ornithine + NADPH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22592", "l": "(9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate = (10Z,15Z)-12-oxophytodienoate"}, {"i": "EC:5.3.99.6", "l": "\"Allene-oxide cyclase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018729", "l": "propionate CoA-transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64130", "l": "L-phenylalanine + octadecanoate => H2O + N-octadecanoyl-L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23083", "l": "L-rhamnonate <=> 2-dehydro-3-deoxy-L-rhamnonate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018826", "l": "RHOT2 hydrolyzes GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47419", "l": "an NDP-alpha-D-glucose + D-glucose <=> a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.21", "l": "\"Maltose epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-378956", "l": "Luteinizing hormone is a heterodimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40878", "l": "(9Z,12Z)-octadecadienoyl-CoA + FAD + H(+) <=> (2E,9Z,12Z)-octadecatrienoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942302", "l": "MMP13 cleaves OPTC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14307", "l": "AMP + diphosphate + L-prolyl-tRNA(Pro) => ATP + L-proline + tRNA(Pro)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18418", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => CMP + ganglioside GM3 (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25877", "l": "L-aspartate + O2 => H2O2 + iminosuccinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166817", "l": "Cleavage of C3 by C3 convertases (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50641", "l": "2-(2-methylsulfanyl)ethylmalate => 3-(2-methylsulfanyl)ethylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29665", "l": "H(+)(out) + xanthine(out) => H(+)(in) + xanthine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61273", "l": "H2O + L-2-aminopentanoate + O2 => 2-oxopentanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32587", "l": "(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 = (3R,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42354", "l": "(R)-6-hydroxynicotine + AH2 => (R)-nicotine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40598", "l": "dodecanedioyl-CoA + H2O <=> CoA + dodecanedioate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26406", "l": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4(+) => H(+) + 4 H2O + phosphate + pyridoxal 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10243", "l": "a 2,3-saturated acyl-[ACP] + NAD(+) <=> a (2E)-enoyl-[ACP] + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45513", "l": "[C-phycocyanin beta-subunit]-Cys(155)-phycocyanobilin => (2R,3E)-phycocyanobilin + apo-[C-phycocyanin beta-subunit]-Cys(155)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193668", "l": "p75NTR and RHOA-GDI interact (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694476", "l": "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 mRNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647631", "l": "GSDMD (1-275) binds PIPs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60895", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O <=> a 5'-end phospho-ribonucleoside in snoRNA + H(+) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047949", "l": "glutarate-semialdehyde dehydrogenase (NAD+) activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102934", "l": "costunolide synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2025890", "l": "Calcineurin binds NFATC1,2,3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2990882", "l": "CDK1 phosphorylates NUP98 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196964", "l": "RFK:Mg2+ phosphorylates RIB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.38"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.71", "l": "\"Pancreatic elastase II\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210300", "l": "Interaction of DAP12 and TREM2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199929", "l": "ERK5 activates the transcription factor MEF2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444691", "l": "Prokineticin receptors bind prokineticin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61733", "l": "steviol + UDP-alpha-D-glucose => H(+) + steviolmonoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696457", "l": "BDH2 dehydrogenates 3HBA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56909", "l": "(7S)-O-acetylsalutaridinol => acetate + H(+) + thebaine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23917", "l": "H(+) + UDP-alpha-D-glucuronate => CO2 + UDP-alpha-D-xylose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507868", "l": "Aquaporins passively transport water into cells (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692315", "l": "OX40L binds OX40 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59558", "l": "H(+) + N,N'-diacetylchitobionate => H2O + N,N'-diacetylchitobiono-1,5-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18070", "l": "L-arginine => D-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202174", "l": "Activation of ZAP-70 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033456", "l": "GCG codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3204318", "l": "cob(II)alamin binds to MTRR:MTR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156661", "l": "Formation of Exon Junction Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853496", "l": "SCF:FBXL7 binds AURKA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0050542", "l": "icosanoid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938108", "l": "SERPINB13 binds cathepsin L (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-912790", "l": "CBL binds CRK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1006143", "l": "CD46 binds C3b (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20764", "l": "(S)-methylmalonyl-CoA + pyruvate = oxaloacetate + propanoyl-CoA"}, {"i": "EC:2.1.3.1", "l": "\"Methylmalonyl-CoA carboxytransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42860", "l": "1,2-dioctanoyl-sn-glycero-3-phosphate + H2O = 1,2-dioctanoyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42811", "l": "2 H(+) + 3 H2O + hydrogen sulfide + 3 oxidized coenzyme F420-(gamma-Glu)(n) <=> 3 reduced coenzyme F420-(gamma-Glu)(n) + sulfite"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103035", "l": "NAD(P)H:methyl-1,4-benzoquinone oxidoreductase activity"}, {"i": "MetaCyc:RXN0-5387"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46173", "l": "ATP + butanoate + CoA => AMP + butanoyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31269", "l": "6-oxohexanoate + H(+) + NADPH => 6-hydroxyhexanoate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21079", "l": "2'-deoxyuridine + 2-oxoglutarate + O2 <=> CO2 + succinate + uridine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65989", "l": "previtamin D3 => calciol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22310", "l": "D-xylose + H2O2 => O2 + xylitol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672304", "l": "IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34153", "l": "2-deoxystreptamine + 2-oxoglutaramate => 3-amino-2,3-dideoxy-scyllo-inosose + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251559", "l": "Deletions of the AMER1 gene prevent expression of AMER1 protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688294", "l": "SIRT5 deacetylates Cytochrome C (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8934819", "l": "Cytoplasmic proteases cleave Profilaggrin producing Filaggrin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56971", "l": "dCTP + pyruvate <=> dCDP + H(+) + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35232", "l": "rifampicin(in) => rifampicin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2509831", "l": "ITPA hydrolyses XTP to XMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404144", "l": "Parenchymal atROL translocates to HSCs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45820", "l": "mesaconate + succinyl-CoA = 2-methylfumaryl-CoA + succinate"}, {"i": "EC:2.8.3.26", "l": "\"Succinyl-CoA:mesaconate CoA transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38262", "l": "(2R,3S)-beta-methylmalyl-CoA <=> glyoxylate + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180885", "l": "Rev multimer-bound HIV mRNA associates with Crm1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64732", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050119", "l": "N-acetylglucosamine deacetylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193700", "l": "p75NTR ICD signals to NF-kB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714691", "l": "RAC3 binds ER effectors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52122", "l": "(19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59262", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57534", "l": "adenosine-5'-diphospho-5'-ribonucleotide-RNA + diphosphate => 5'-end ribonucleotide-RNA + ATP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047209", "l": "coniferyl-alcohol glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45937", "l": "3-methylundecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(4-methyl-2-oxododecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35339", "l": "3-hydroxyicosanoyl-CoA + NADP(+) = 3-oxoeicosanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22950", "l": "D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => D-tagatofuranose 1,6-bisphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25335", "l": "H2O + L-cysteinyl-tRNA(Cys) => H(+) + L-cysteine + tRNA(Cys)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16900", "l": "a 3beta-hydroxysteroid + a triacylglycerol <=> a 3beta-hydroxysteroid ester + a diacylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n14"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40630", "l": "H2O + trihexadecanoylglycerol <=> 2,3-dihexadecanoyl-sn-glycerol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443779", "l": "Linkage of L1 with treadmilling F-actin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166869", "l": "TRAF6 binds MEKK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006490", "l": "MECP2 binds the GRIN2A gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23845", "l": "ATP + sedoheptulose => ADP + D-sedoheptulose 7-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24943", "l": "1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NADP(+) = 4-hydroxy-L-glutamate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2990882", "l": "CDK1 phosphorylates NUP98 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603419", "l": "Activated NTRK3 binds SRC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9015111", "l": "Factor Xa inhibitors binds Xa (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49166", "l": "5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide c + H(+) + L-methionine => a bacteriochlorophyllide c + H2O + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52821", "l": "L-serine + succinyl-CoA => CoA + O-succinyl-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32759", "l": "L-lysine = (3R)-3-methyl-D-ornithine"}, {"i": "EC:5.4.99.58", "l": "\"Methylornithine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004046", "l": "aminoacylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2197588", "l": "NICD2 binds RBPJ and MAML in the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40668", "l": "2-aminoprop-2-enoate => 2-iminopropanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2429719", "l": "MCPH1 sequesters condensin II (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49736", "l": "2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate = CO2 + deoxyviolacein + 2 H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15353", "l": "all-trans-violaxanthin + L-ascorbate = all-trans-antheraxanthin + H2O + L-dehydroascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27597", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 5 isopentenyl diphosphate <=> all-trans-nonaprenyl diphosphate + 5 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709098", "l": "DHFR dimer reduces FOLA to DHF (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008823", "l": "cupric reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647631", "l": "GSDMD (1-275) binds PIPs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429992", "l": "PARN deadenylates mRNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004127", "l": "cytidylate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706399", "l": "RHOBTB3 hydrolyzes ATP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32480", "l": "2 iodide + L-tyrosine + 2 NADP(+) => 3,5-diiodo-L-tyrosine + H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "79.238648346243679", "identifiers": [{"i": "GO:0035173", "l": "histone kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32202", "l": "androsta-1,4-diene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0036318", "l": "peptide pheromone receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58047", "l": "a long-chain fatty acyl-CoA + alpha,alpha-trehalose <=> 2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534365", "l": "Slo3 Potassium Transport (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.25", "l": "\"Thiomorpholine-carboxylate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15819", "l": "H2O2 + NH4(+) + pyridoxal 5'-phosphate => H2O + O2 + pyridoxamine 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371527", "l": "HSF1 trimer translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047676", "l": "arachidonate-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149432", "l": "Transport of VPU to Plasma Membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689085", "l": "ATXN3 binds polyUb-PARK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24496", "l": "4-O-deacetylvindoline + acetyl-CoA = CoA + vindoline"}, {"i": "EC:2.3.1.107", "l": "\"Deacetylvindoline O-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39007", "l": "a cholesterol ester(in) = a cholesterol ester(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38695", "l": "a cardiolipin(in) = a cardiolipin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59228", "l": "6-sulfo-alpha-D-quinovose = 6-sulfo-beta-D-quinovose"}, {"i": "EC:5.1.3.43", "l": "\"Sulfoquinovose mutarotase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27339", "l": "15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin] => 2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58301", "l": "25-substituted-cholesterol + beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine => 25-substituted-cholesteryl beta-D-glucoside + N-octadecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21146", "l": "5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-Glu)(n) => 5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10453", "l": "2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + O2 + reduced [NADPH--hemoprotein reductase] => (R)-dihydrocamalexate + 2 H(+) + 2 H2O + hydrogen cyanide + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-167419", "l": "The receptor:G-protein complex releases GDP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24745", "l": "2-aminobut-2-enoate + H2O <=> 2-oxobutanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65125", "l": "benzoyl-CoA + ethanol => benzyl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41717", "l": "a 2-acyl-sn-glycero-3-phospho-L-serine + H2O => a 2-acyl-sn-glycerol 3-phosphate + H(+) + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420883", "l": "Opsins act as GEFs for G alpha-t (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11681", "l": "ATP + H2O + L-glutamine + XMP => AMP + diphosphate + GMP + 2 H(+) + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18862", "l": "a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine => a 5-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54086", "l": "archaeosine(15) in tRNA + L-glutamate => 7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029453", "l": "Phosphorylation of VAV (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39526", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA <=> (2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213207", "l": "Formation of collagen networks (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34046", "l": "5-phospho-alpha-D-ribose 1-diphosphate + neamine <=> 5''-phosphoribostamycin + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47304", "l": "(9Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0016670", "l": "oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor"}, {"i": "EC:1.8.3.-", "l": "\"With oxygen as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5660665", "l": "Caspase-8 binds MALT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56819", "l": "a pyrimidine ribonucleoside + H2O <=> a pyrimidine nucleobase + D-ribose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47581", "l": "ganglioside GT3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GT2 (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34379", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 UDP-alpha-D-galactofuranose = beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 H(+) + 2 UDP"}, {"i": "EC:2.4.1.287", "l": "\"Rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,4/1,5-galactofuranosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139893", "l": "Granzyme-B activates BID by cleavage (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35935", "l": "2 ATP + L-proline + L-tryptophan = 2 AMP + brevianamide F + 2 diphosphate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45658", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42229", "l": "17beta-estradiol + A => AH2 + estrone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950423", "l": "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33683", "l": "H(+) + L-serine + octadecanoyl-CoA = 3-oxoeicosasphinganine + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29320", "l": "H2O + sn-glycero-3-phosphoethanolamine => ethanolamine + H(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-350651", "l": "Caspase-mediated cleavage of MASK (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035575", "l": "histone H4-methyl-lysine-20 demethylase activity"}, {"i": "REACT:R-HSA-2172678", "l": "PHF8 demethylates histone H4K20me1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8960973", "l": "RLBP1:11cRAL dissociates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102979", "l": "homofuraneol oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086039", "l": "P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35828", "l": "H2O + N(1)-aminopropylagmatine => spermidine + urea"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140395", "l": "averantin hydroxylase activity"}, {"i": "RHEA:35575", "l": "(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] = (1'S,5'R)-5'-hydroxyaverantin + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31715", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 11alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983421", "l": "Journey of cargo through Golgi complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14074", "l": "3-hydroxy-L-glutamate + H(+) => 4-amino-3-hydroxybutanoate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54336", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline = 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15752", "l": "(S)-mandelate + A <=> AH2 + phenylglyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59489", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate => ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2201293", "l": "Endocytosis of TLR4:LY96:LPS:CD14 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6794346", "l": "NRXNs bind NLGNs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0070704", "l": "sterol desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38130", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol <=> 1-octadecanoyl-2-(9Z)-octadecenoylglycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1006143", "l": "CD46 binds C3b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647746", "l": "EML4 trimerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904929", "l": "coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66040", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49369", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+) => 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805943", "l": "S100A1 binds TLR4:LY96 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.15", "l": "\"Cathepsin L\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050349", "l": "triacetate-lactonase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25949", "l": "a 1,2-diacyl-sn-glycerol + CTP => a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65003", "l": "holo-[ACP] + octanoyl-AMP <=> AMP + H(+) + octanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.42", "l": "\"Thermopsin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12712", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14049", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4,11-diene = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol"}, {"i": "EC:1.14.14.176", "l": "\"Taxadiene 5-alpha-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36189", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1-O-alkyl-2-acyl-sn-glycerol + CDP-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188002", "l": "Rab5-mediated recruitment of class III PI3K to TLR9 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64517", "l": "2-hydroxyethane-1-sulfonate + NAD(+) => H(+) + NADH + sulfoacetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25489", "l": "(2E)-geranyl diphosphate => (1S,5S)-alpha-pinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676589", "l": "RANKL,sRANKL trimer binds RANK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34352", "l": "(2E)-geranial + H2O + NAD(+) => geranate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59066", "l": "luteothin + S-adenosyl-L-homocysteine => demethylluteothin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024386", "l": "Oxysterol-induced binding of NR1H2,3:RXR to the ABCG1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380311", "l": "Recruitment of Plk1 to centrosomes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158118", "l": "factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49095", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H2O <=> H(+) + hexadecanoate + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626046", "l": "p-GFAP binds EEF1A1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034006", "l": "amorpha-4,11-diene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37498", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.3.4", "l": "\"D-lysine 5,6-aminomutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34591", "l": "Co-precorrin-7 + S-adenosyl-L-methionine = Co-precorrin-8X + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.289", "l": "\"Cobalt-precorrin-7 (C(5))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31420", "l": "(2Z,6E)-farnesyl diphosphate => (-)-beta-curcumene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341048", "l": "SUMOylation of RXRA with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54436", "l": "2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 = a (4S)-2,3-dehydroflavan-3,4-diol + CO2 + H(+) + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102509", "l": "cyanidin 3,5-diglucoside glucosidase activity"}, {"i": "MetaCyc:RXN-14436"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950347", "l": "IL12A:IL12B translocates from late endosome lumen to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17580", "l": "ADP-D-glycero-beta-D-manno-heptose <=> ADP-L-glycero-beta-D-manno-heptose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483174", "l": "PE is methylated to PC by PEMT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349404", "l": "CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36632", "l": "D-ribulose 1,5-bisphosphate + O2 => (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59564", "l": "H2O + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone = H(+) + N,N',N'',N'''-tetraacetylchitotetraonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11625", "l": "2-(hydroxyimino)propanoate + acetone => acetone oxime + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9687638", "l": "MLKL binds IP4, IP5 and IP6  (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30877", "l": "6-amino-2-oxohexanoate + D-glutamate => 2-oxoglutarate + D-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193656", "l": "p75NTR interacts with RIP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936590", "l": "sulfur transfer to carrier protein (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14879", "l": "ADP + L-glutamyl 5-phosphate => ATP + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070061", "l": "fructose binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14456", "l": "4-(phosphooxy)-L-threonine + NAD(+) <=> (2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55536", "l": "an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose = a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17134", "l": "ATP + L-seryl-[tyrosine-3-monooxygenase] => ADP + H(+) + O-phospho-L-seryl-[tyrosine-3-monooxygenase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390598", "l": "Myosin Binds ATP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45318", "l": "11beta-prostaglandin F2 + NADP(+) => H(+) + NADPH + prostaglandin D2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811427", "l": "COPI vesicle uncoating at the ER (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372819", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43371", "l": "dodecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(2-oxotridecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839100", "l": "p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004957", "l": "prostaglandin E receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29776", "l": "alpha-D-ribose 1-phosphate + ATP => ADP + alpha-D-ribose 1,5-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.31"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32752", "l": "choline(out) => choline(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83788", "l": "Binding of TFIIIC to Type 2 promoter (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14182", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 => (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635102", "l": "GPR161 is internalized (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61966", "l": "2 [Fe(III)-cytochrome b5] + a 1-O-(1Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H2O => 2 [Fe(II)-cytochrome b5] + a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21601", "l": "anthranilate + benzoyl-CoA => CoA + N-benzoylanthranilate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52655", "l": "lanosterol + S-adenosyl-L-methionine <=> 24-methylene-24-dihydrolanosterol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16182", "l": "3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine => 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636297", "l": "PtpA binds TRIM27 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47908", "l": "6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O = 6-deoxy-6-sulfo-D-gluconate + H(+)"}, {"i": "EC:3.1.1.99", "l": "\"6-deoxy-6-sulfogluconolactonase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50528", "l": "acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14534", "l": "creatinine + H2O => creatine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59669", "l": "D-cellohexaose + O2 => D-cellohexaono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60153", "l": "H2O + L-gamma-glutamyl-L-glutamyl-[protein] => L-glutamate + L-glutamyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55792", "l": "butan-2-one + H(+) + NADH + O2 = 1-hydroxy-2-butanone + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47130", "l": "AMP + deoxycholoyl-CoA + diphosphate => ATP + CoA + deoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64671", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14946", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-888589", "l": "Release of GABA at the synapse (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683879", "l": "SFTPA genes produce SFTPA proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.n2", "l": "\"Glucoside xylosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114354", "l": "SMAC binds XIAP:Caspase-7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38850", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33040", "l": "4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin => 2-oxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112396", "l": "Separation of elongating transcript from template (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693347", "l": "CRYM reduces P2C to PPCA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39284", "l": "a long-chain fatty acid(out) => a long-chain fatty acid(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-947514", "l": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419389", "l": "LPA-binding receptors bind LPA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607058", "l": "Activated protein C:PROCR binds F2R (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388817", "l": "ICOS binds ICOSL/B7-H2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32089", "l": "[4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-(S)-4,6-CH3(COO(-))C-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphate => [4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850961", "l": "PREX2 binds PTEN and inhibits it (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33518", "l": "2 5,6-dihydroxyindole + O2 <=> 2 H2O + 2 indole-5,6-quinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28710", "l": "Cd(2+)(in) <=> Cd(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018538", "l": "DLGAP5 gene transcription is stimulated by NOTCH3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9696275", "l": "RND2 binds GTP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60903", "l": "a cytidine in RNA + S-adenosyl-L-methionine <=> an N(3)-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18723", "l": "diphosphate + ent-13-epi-manoyl oxide => ent-8alpha-hydroxylabd-13-en-15-yl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193703", "l": "IKKbeta is activated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24035", "l": "sucrose <=> 6-O-alpha-D-glucopyranosyl-D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11667", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + CMP-N-acetyl-beta-neuraminate <=> 1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018747", "l": "RHOQ GEFs activate RHOQ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13934", "l": "all-trans-retinyl hexadecanoate + H2O => all-trans-retinol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944026", "l": "SNAI1,SNAI2 bind the PTEN gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23408", "l": "NADP(+) + precorrin-6B = 2 H(+) + NADPH + precorrin-6A"}, {"i": "EC:1.3.1.54", "l": "\"Precorrin-6A reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420117", "l": "VEGFR2 autophosphorylates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42124", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 3alpha-hydroxy-5alpha-androstan-17-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63469", "l": "all-trans-octaprenol + ATP => ADP + all-trans-octaprenyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55347", "l": "(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol <=> 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454699", "l": "AMPK-alpha2 phosphorylates TBC1D1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58396", "l": "4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + 5 H(+) + O2 + 4 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NH4(+) + 4 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9613497", "l": "Unwinding DNA for the nascent transcript (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578712", "l": "Importin-8 binds AGO2:miRNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191656", "l": "Closure of gap junction (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32398", "l": "(1S,2S,4S)-dihydrocarveol + NAD(+) <=> (1S,4S)-dihydrocarvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25767", "l": "3-carboxy-2-oxobutanoate + H(+) = 2-oxobutanoate + CO2"}, {"i": "EC:1.1.1.n5", "l": "\"3-methylmalate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31615", "l": "dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-adenosyl-L-methionine = dTDP-D-ravidosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.236", "l": "\"dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004789", "l": "thiamine-phosphate diphosphorylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8873850", "l": "STARD5 binds DCA, LCA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.72", "l": "\"Delta(24)-sterol reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445072", "l": "Interaction of PAK1 with Rac1-GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668404", "l": "TNFA binds TNFR2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60680", "l": "(+)-artemisinic aldehyde + H2O + NADP(+) = (+)-artemisinate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9006870", "l": "IL21 receptor STAT phosphorylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630795", "l": "p16INK4A mutants do not bind CDK4,CDK6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848939", "l": "PTK6 binds KHDRBS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11660", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = a 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate"}, {"i": "EC:3.5.1.89", "l": "\"N-acetylglucosaminylphosphatidylinositol deacetylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641229", "l": "TLE oligomerizes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47410", "l": "(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA => (24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40283", "l": "(R)-carnitine + hexadecanedioyl-CoA = CoA + O-hexadecanedioyl-L-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16062", "l": "H2O + sn-glycerol 3-phosphocholine => choline + H(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050043", "l": "lactate racemase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48564", "l": "9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60013", "l": "a tRNA with a 3' CC end + ATP => a tRNA with a 3' CCA end + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0035252", "l": "UDP-xylosyltransferase activity"}, {"i": "REACT:R-HSA-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391377", "l": "Luteinizing hormone receptor can bind LH (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-844447", "l": "NLRP1 senses MDP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52149", "l": "an (E)-omega-(methylsulfanyl)alkyl-thiohydroximate + UDP-alpha-D-glucose => an aliphatic desulfo-glucosinolate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374663", "l": "DCC interaction with Ezrin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73577", "l": "CAD hexamer transforms L-Gln to CAP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75187", "l": "TRAIL:TRAIL receptor trimers bind FADD (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52496", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10390", "l": "CO2 + GDP + phosphoenolpyruvate => GTP + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381608", "l": "cAMP activates EPAC2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23467", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174121", "l": "Association of Securin with Cdc20:APC/C complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686430", "l": "MUS81 binds EME1, EME2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "74.603620314006946", "identifiers": [{"i": "GO:0005262", "l": "calcium channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9615348", "l": "AGT(34-41) binds to AGTR2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140417", "l": "ATP-sensitive calcium-release channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627106", "l": "SMAC (DIABLO) forms dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53542", "l": "(13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine => (13R)-S-cysteinylglycinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0015146", "l": "pentose transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65383", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidyl-adenosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidyl-adenosine in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11852", "l": "phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.69", "l": "\"Monoterpenol O-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483089", "l": "PE is converted to PS by PTDSS2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.12", "l": "\"Envelysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202375", "l": "Recruitment of ITK to SLP-76 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607744", "l": "MALT1 binds BCL10 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102402", "l": "2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity"}, {"i": "MetaCyc:RXN-13694"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33799", "l": "L-histidinol + NAD(+) = H(+) + L-histidinal + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37172", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA => 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1235035", "l": "Expression of Carbonic Anhydrase IX (CA9) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466370", "l": "NRF1:PPARGC1B binds the CYCS promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-981728", "l": "Factor H binds to membrane-associated C3b (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56563", "l": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose <=> [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15747", "l": "[(2->1)-beta-D-fructosyl](n+1) + D-glucose => [(2->1)-beta-D-fructosyl](n) + sucrose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847968", "l": "PTEN binds FRK (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018766", "l": "RHOU binds effectors at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36133", "l": "methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine => (indol-3-yl)acetate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47611", "l": "3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37191", "l": "2',3'-cyclic AMP + H2O = adenosine 2'-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11026", "l": "ADP + 2 H(+) + phosphoramidate => ATP + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58363", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 <=> (5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8856808", "l": "Recruitment of AP-2 complex and clathrin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63771", "l": "2 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32884", "l": "(11R)-dihydroartemisinic aldehyde + NADP(+) => (+)-artemisinic aldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30372", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O => (-)-geosmin + acetone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730903", "l": "Oligomerization of TRAF6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102167", "l": "[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17483", "l": "2 cob(II)alamin + NADH => 2 cob(I)alamin + H(+) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050269", "l": "coniferyl-aldehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42173", "l": "(11Z)-eicosenoyl-CoA + AH2 + O2 => (8Z,11Z)-eicosadienoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "65.555602785606126", "identifiers": [{"i": "GO:0016407", "l": "acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043771", "l": "cytidine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549322", "l": "OCT1 transports organic cations out of hepatic cells (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45619", "l": "H2O + N-hexanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexanoyl ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56522", "l": "2 5'-deoxyadenosine + 2 CO2 + heme b + 2 L-methionine => Fe-coproporphyrin III + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17721", "l": "a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]"}, {"i": "EC:1.3.8.8", "l": "\"Long-chain-acyl-CoA dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51499", "l": "a sphingoid base + ATP <=> a sphingoid 1-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018623", "l": "benzoate 1,2-dioxygenase activity"}, {"i": "RHEA:12633", "l": "benzoate + H(+) + NADH + O2 = (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+)"}, {"i": "EC:1.14.12.10", "l": "\"Benzoate 1,2-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28101", "l": "ATP + GDP <=> AMP + guanosine 3',5'-bis(diphosphate)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61848", "l": "cholesterol + UDP-alpha-D-glucose = cholesteryl 3-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32277", "l": "3-amino-2-oxopropyl phosphate + CO2 + NADH => 4-(phosphooxy)-L-threonine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23121", "l": "a dipeptide(out) + ATP + H2O => a dipeptide(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34835", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-4-hydroxy-15-methylhexadecasphinganine = a 1,2-diacyl-sn-glycerol + N-acyl-4-hydroxy-15-methylhexadecasphinganine-1-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45335", "l": "7,8-dihydroneopterin + O2 <=> 7,8-dihydroxanthopterin + formate + glycolaldehyde + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49394", "l": "20S,23,24-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655823", "l": "Expression of Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37667", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP"}, {"i": "EC:2.4.1.313", "l": "\"Protein O-mannose beta-1,3-N-acetylgalactosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.92", "l": "\"Endopeptidase Clp\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683672", "l": "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.49", "l": "\"Bothropasin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209253", "l": "Autophosphorylated FU phosphorylates COS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693540", "l": "MRN activates ATM (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784765", "l": "p-Y705-STAT3 dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32680", "l": "(2E)-geranyl diphosphate + H2O => (2E)-geraniol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24370", "l": "L-proline + NH4(+) => L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209566", "l": "TRAF6 is auto-ubiquitinated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35280", "l": "acetyl-CoA + hexadecanoyl-CoA => 3-oxooctadecanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.14", "l": "\"Rhodopsin kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20512", "l": "ATP + viomycin <=> ADP + H(+) + O-phosphoviomycin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417890", "l": "P2Y5 receptor can bind to LPA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29129", "l": "a menaquinone + H2O + nitrite => a menaquinol + nitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0019238", "l": "cyclohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26381", "l": "4-hydroxybutanoate + NADP(+) = H(+) + NADPH + succinate semialdehyde"}, {"i": "EC:1.1.1.n11", "l": "\"Succinic semialdehyde reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2900748", "l": "NOTCH1 HD+PEST domain mutants bind DLL1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42419", "l": "a ubiquinone + L-proline <=> (S)-1-pyrroline-5-carboxylate + a ubiquinol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047927", "l": "gibberellin-44 dioxygenase activity"}, {"i": "RHEA:16033", "l": "2-oxoglutarate + gibberellin A44 + O2 = CO2 + gibberellin A19 + H2O + succinate"}, {"i": "EC:1.14.11.12", "l": "\"Gibberellin-44 dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5695964", "l": "ABHD14B hydrolyses PNPB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388808", "l": "CD28 homodimer binds B7-2 monomer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033225", "l": "ATPase-coupled 2-aminoethylphosphonate transporter activity"}, {"i": "RHEA:32775", "l": "(2-aminoethyl)phosphonate(out) + ATP + H2O = (2-aminoethyl)phosphonate(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9006850", "l": "IL21 receptor JAK phosphorylation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2318373", "l": "Defective GUSB does not hydrolyse (HA)2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15614", "l": "NAD(+) + precorrin-2 => 2 H(+) + NADH + sirohydrochlorin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036055", "l": "protein-succinyllysine desuccinylase activity"}, {"i": "RHEA:47668", "l": "H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354077", "l": "Integrin alphaIIb beta3 activation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57192", "l": "H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] = glycolate + H(+) + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9679029", "l": "C-ter TLR7 dimer binds HCQ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163820", "l": "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9645598", "l": "RRAGC,D hydrolyzes GTP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265301", "l": "Corticotropin cleavage from POMC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46024", "l": "H2O2 + tetradecanoate = (3R)-hydroxytetradecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48029", "l": "H2O + triacetin => acetate + diacetylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696547", "l": "STAMBPL1 is a deubiquitinase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814831", "l": "TBC1D20 binds RAB1:GTP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60163", "l": "ATP + H2O + vincristine(in) <=> ADP + H(+) + phosphate + vincristine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34424", "l": "(-)-secoisolariciresinol + NADP(+) => (+)-lariciresinol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47719", "l": "4-pregnen-20,21-diol-3-one + NAD(+) <=> 21-hydroxyprogesterone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10784", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(36)-[histone H3] + O2 = CO2 + formaldehyde + L-lysyl(36)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "56.548882693046274", "identifiers": [{"i": "GO:0008324", "l": "cation transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003865", "l": "3-oxo-5-alpha-steroid 4-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211193", "l": "Homodimerization  of DFF40 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58887", "l": "AH2 + alpha-N-dichloroacetyl-p-aminophenylserinol + 2 O2 <=> A + chloramphenicol + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46882", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52205", "l": "butachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => butyl formate + H2O + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389026", "l": "Galanin receptors can bind galanin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852331", "l": "GTSE1 translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392195", "l": "Gi activation by P2Y purinoceptor 12 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36809", "l": "3-oxo-triacontanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + octacosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21259", "l": "3-phosphoshikimate + phosphoenolpyruvate <=> 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199839", "l": "AKT can phosphorylate RSK (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54127", "l": "coelenterazine h dioxetanone <=> CO2 + excited coelenteramide h monoanion + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52527", "l": "O2 + prostaglandin A1 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy prostaglandin A1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.32"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24831", "l": "ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate => ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977375", "l": "CR1 binds C3bBb/C4bC2a (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254392", "l": "PGR gene expression is stimulated by ERBB4s80:ESR1:estrogen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40081", "l": "22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => docosanoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10531", "l": "dihydrosanguinarine + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxydihydrosanguinarine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669023", "l": "TWEAK binds FN14 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66382", "l": "ADP + glutathione(out) + glycodeoxycholate(out) + H(+) + phosphate => ATP + glutathione(in) + glycodeoxycholate(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51865", "l": "(2E)-geranyl diphosphate + esculetin => 8-geranylesculetin + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30455", "l": "(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O = (-)-geosmin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30012", "l": "ATP + beta-D-galactose(out) + H2O => ADP + beta-D-galactose(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647631", "l": "GSDMD (1-275) binds PIPs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65076", "l": "dauca-4,7-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = asperaculane D + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49512", "l": "2-(phosphinatomethylidene)butanedioate + H2O = phosphinomethylisomalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56612", "l": "L-cysteinyl-[protein] + NAD(+) = H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45099", "l": "(9Z)-hexadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-hexadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.20", "l": "\"Beta-Ala-His dipeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56537", "l": "(12R)-hydroxy-(9Z)-octadecenoyl-CoA + 1,2-di-(12R-hydroxy-9Z-octadecenoyl)-sn-glycerol => 1,2,3-tri-(12R-hydroxy-9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211959", "l": "CYP3A43 6b-hydroxylates TEST (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19429", "l": "[beta-adrenergic receptor] + ATP = [beta-adrenergic receptor]-phosphate + ADP + H(+)"}, {"i": "EC:2.7.11.15", "l": "\"[Beta-adrenergic-receptor] kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.108", "l": "\"HtrA2 peptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785213", "l": "LIPC dimer binds heparin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783483", "l": "tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51601", "l": "2 H(+) + m-xylene + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.8"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004878", "l": "complement component C5a receptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047045", "l": "testosterone 17-beta-dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106365", "l": "beta-carotene isomerase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008503", "l": "benzodiazepine receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26287", "l": "Co-precorrin-6A + S-adenosyl-L-homocysteine => Co-precorrin-5B + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159733", "l": "Furin cleaves pro-factor X to factor X (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2317332", "l": "PIP3 recruits AKT to the membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0008988", "l": "rRNA (adenine-N6-)-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033820", "l": "DNA alpha-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56800", "l": "apo-[corrinoid adenosyltransferase] + cob(II)yrinate a,c diamide = cob(II)yrinate a,c diamide--[corrinoid adenosyltransferase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54953", "l": "ATP + CoA + nonanoate => AMP + diphosphate + nonanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45067", "l": "H2O + N-hexadecanoylethanolamine <=> ethanolamine + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37789", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047684", "l": "arylamine glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57477", "l": "dodecanoate + H2O2 => 2-hydroxydodecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76500", "l": "TBXAS1 isomerises PGH2 to TXA2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36038", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+) <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663426", "l": "sCD163 binds MYH9 in T-cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76466", "l": "CYP4A11 12-hydroxylates DDCX (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014449", "l": "RHOG binds effectors at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102479", "l": "quercetin 3-O-beta:-D-galactosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791302", "l": "TP53 binds the AIFM2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852013", "l": "BTNL8 binds resting T cell surface (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0061783", "l": "peptidoglycan muralytic activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-877187", "l": "P2X7 mediates loss of intracellular K+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665989", "l": "DIAPH1 binds RHOA:GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57633", "l": "ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + ML-236A carboxylate + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050392", "l": "vicianin beta-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28400", "l": "L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate => H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161293", "l": "Tropoelastin forms aggregate globules (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28226", "l": "(+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.149", "l": "\"5-epiaristolochene 1,3-dihydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0001846", "l": "opsonin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49370", "l": "19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate => 19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5687107", "l": "MAPK4,6 translocate to nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2471621", "l": "Endostatin degradation by cathepsins (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50206", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate => (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18322", "l": "2-oxoglutarate + L-leucine => 4-methyl-2-oxopentanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37560", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013108", "l": "GDIs block activation of RHOC (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941895", "l": "Formation of CDK4/6:CCND complexes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70482", "l": "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036105", "l": "peroxisome membrane class-1 targeting sequence binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61044", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = (-)-(R)-19-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68954", "l": "Mcm2-7 is phosphorylated by DDK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865605", "l": "BRWD1 binds SMARCA4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58524", "l": "15alpha-stemmadenine intermediate I + H2O + NADPH = (16S)-deshydroxymethyl-stemmadenine + formate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0031745", "l": "cysteinyl leukotriene receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047615", "l": "actinomycin lactonase activity"}, {"i": "MetaCyc:ACTINOMYCIN-LACTONASE-RXN"}, {"i": "EC:3.1.1.39", "l": "\"Actinomycin lactonase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41117", "l": "1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57668", "l": "alpha-nootkatol + O2 + reduced [NADPH--hemoprotein reductase] = (+)-nootkatone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54060", "l": "(2E,6E)-farnesyl diphosphate + H2O = (2Z,6E)-hedycaryol + diphosphate"}, {"i": "EC:4.2.3.187", "l": "\"(2Z,6E)-hedycaryol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25769", "l": "2-oxobutanoate + CO2 => 3-carboxy-2-oxobutanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2317314", "l": "AKT binds PDPK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62881", "l": "9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + AH2 => (3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37902", "l": "2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2 <=> 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17475", "l": "7,8-dihydroneopterin 3'-triphosphate + formate + H(+) => GTP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4570493", "l": "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106140", "l": "P-TEFb complex binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005095", "l": "GTPase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65228", "l": "(1S,2S)-1,2-dihydronaphthalene-1,2-diol + NADP(+) = H(+) + NADPH + naphthalene-1,2-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44981", "l": "(R)-carnitine + butanoyl-CoA => CoA + O-butanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21722", "l": "H2O + hydrogen cyanide => formamide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102059", "l": "2-cis,6-cis-farnesyl pyrophosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66362", "l": "(3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H(+) => (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57992", "l": "(20S)-ginsenoside C-K + UDP-alpha-D-glucose = (20S)-ginsenoside F2 + H(+) + UDP"}, {"i": "RHEA:57996", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose = (20S)-ginsenoside Rh2 + H(+) + UDP"}, {"i": "EC:2.4.1.364", "l": "\"Protopanaxadiol-type ginsenoside 3-O-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187506", "l": "Translocation of p27 to the nucleoplasm (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43670", "l": "2-carboxyhexacosanoyl-CoA + ADP + H(+) + phosphate => ATP + hexacosanoyl-CoA + hydrogencarbonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034319", "l": "alcohol O-butanoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22062", "l": "2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] => (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003972", "l": "RNA ligase (ATP) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16250", "l": "alpha-D-glucose 6-phosphate => beta-D-glucose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.24", "l": "\"Candidapepsin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507871", "l": "Aquaporins passively transport glycerol out of cells (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44788", "l": "2-demethylmenaquinol-11 + S-adenosyl-L-methionine = H(+) + menaquinol-11 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16909", "l": "2 [Fe(III)cytochrome c] + glycine + H2O = 2 [Fe(II)cytochrome c] + glyoxylate + 2 H(+) + NH4(+)"}, {"i": "EC:1.4.2.1", "l": "\"Glycine dehydrogenase (cytochrome)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56932", "l": "androst-5-en-3beta,17beta-diol + NAD(+) = 17beta-hydroxy-androst-5-en-3-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32727", "l": "a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA"}, {"i": "EC:2.3.1.199", "l": "\"Very-long-chain 3-oxoacyl-CoA synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.16"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030197", "l": "extracellular matrix constituent, lubricant activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865454", "l": "CBFB binds RUNX3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38979", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38483", "l": "a 2,3-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29205", "l": "dimethyl sulfide + H2O + menaquinone-8 => dimethyl sulfoxide + menaquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18774", "l": "[methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M => [Co(I) methylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65667", "l": "citrate(out) + 4 Na(+)(out) <=> citrate(in) + 4 Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052656", "l": "L-isoleucine transaminase activity"}, {"i": "KEGG.REACTION:R02199"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371582", "l": "HSBP1 binds HSF1 trimer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83660", "l": "Membrane-anchored TNF-alpha binds TNFR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10378", "l": "ADP + Cu(2+)(out) + H(+) + phosphate => ATP + Cu(2+)(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29018", "l": "phosphate(out) + sn-glycerol 3-phosphate(in) <=> phosphate(in) + sn-glycerol 3-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9633044", "l": "ESR binds STRN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417896", "l": "P2Y6 receptor can bind to UDP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45425", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874194", "l": "MBTPS2 (S2P) cleaves CREB3L1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61332", "l": "ATP + H2O + indoxyl sulfate(in) = ADP + H(+) + indoxyl sulfate(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1008240", "l": "NFE2 is a heterodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21045", "l": "24-methylidenelophenol + S-adenosyl-L-methionine => (Z)-24-ethylidenelophenol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67123", "l": "N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426150", "l": "SREBP1A,1C,2 binds the HMGCS1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983158", "l": "Trimming of peptides in ER (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044377", "l": "RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39258", "l": "(13Z)-3-oxodocosenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(13Z)-docosenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50190", "l": "N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56683", "l": "beta-dihydromenaquinone-9 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005019", "l": "platelet-derived growth factor beta-receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51073", "l": "a phenol + a phenyl sulfate => a phenol + a phenyl sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52626", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ADP + H(+) + phosphate => [amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132074", "l": "Cleavage of surface-bound factor B (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22122", "l": "GDP + phosphate + succinyl-CoA => CoA + GTP + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015109", "l": "chromate transmembrane transporter activity"}, {"i": "RHEA:32819", "l": "chromate(in) = chromate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013158", "l": "CDC42 GDIs block activation of CDC42 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700662", "l": "(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21188", "l": "ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)"}, {"i": "EC:6.3.1.5", "l": "\"NAD(+) synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052661", "l": "S-lactaldehyde reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2562526", "l": "PLK1 phosphorylates OPTN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59816", "l": "a long-chain fatty acyl-CoA + a sterol = a sterol ester + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4093327", "l": "EPHA binds TIAM1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450474", "l": "MK2 phosphorylates BRF1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63676", "l": "CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+) = (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29006", "l": "H(+)(out) + L-homoserine(in) <=> H(+)(in) + L-homoserine(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043894", "l": "acetyl-CoA synthetase acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50172", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43591", "l": "globoside NORint + UDP-alpha-D-galactose <=> globoside NOR2 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44749", "l": "5-amino-1-(beta-D-ribosyl)imidazole + ATP => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31668", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-glucose => dTDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097627", "l": "high-affinity L-ornithine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31567", "l": "bisphenol A + H(+) + NADH + O2 = 2,2-bis(4-hydroxyphenyl)-1-propanol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33308", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein] => (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56978", "l": "4-hydroxybenzyl alcohol + 2 H(+) + 2 reduced [azurin] => 4-methylphenol + H2O + 2 oxidized [azurin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40591", "l": "decanedioyl-CoA + H2O = CoA + decanedioate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17203", "l": "2,5-dioxopentanoate + H2O => 2-dehydro-3-deoxy-L-arabinonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5665871", "l": "ADRM1 binds 26S proteasome (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43523", "l": "2-carboxy-5-(dihydroxymethyl)furan + O2 <=> 2,5-dicarboxyfuran + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19151", "l": "H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide => L-arginyl-[protein] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13688", "l": "5alpha-cholest-7-en-3beta-ol + NADP(+) <=> 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61274", "l": "2-oxopentanoate + H2O2 + NH4(+) => H2O + L-2-aminopentanoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28553", "l": "acetyl-CoA + anthranilate <=> CoA + N-acetylanthranilate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610733", "l": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24254", "l": "2 ADP + 2 H(+) => H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58180", "l": "(1R,2R,3R)-prephytoene diphosphate + H(+) + NADPH = all-trans-lycopaoctaene + diphosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34845", "l": "7,8-dihydromonapterin + 2 H(+) + 3 phosphate => 7,8-dihydromonapterin 3'-triphosphate + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63540", "l": "H2O + neurotensin = L-leucine + neurotensin-(1-12)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48153", "l": "ganglioside GD1b(d18:1(4E)/18:0) + H2O => ganglioside GM1 (d18:1(4E)/18:0) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41331", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> (12S)-hydroperoxy-(8Z,10E,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41333", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005154", "l": "epidermal growth factor receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607043", "l": "factor VIIIa associates with cell membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60784", "l": "2-oxoglutarate + gibberellin A24 + O2 = CO2 + gibberellin A25 + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.-", "l": "\"Other carbon-oxygen lyases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36026", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944233", "l": "Association of procollagen type XIX (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684006", "l": "KPNA2 translocates NBN to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27891", "l": "3'-UMP + H2O => phosphate + uridine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25899", "l": "H(+) + malonate <=> acetate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53653", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 => (5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48112", "l": "N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981610", "l": "Neuroglobin binds oxygen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28512", "l": "beta-D-glucose 6-phosphate + hydroquinone => arbutin 6-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0031628", "l": "opioid receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5387386", "l": "Hh processing variants are recruited to SEL1:SYVN at the ER membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14608", "l": "D-glucose 6-phosphate + GDP-alpha-D-glucose <=> alpha,alpha-trehalose 6-phosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2327746", "l": "FN1 aggregation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227755", "l": "Recruitment of IKK complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21002", "l": "1,2,3,5-tetrahydroxybenzene + 1,3,5-trihydroxybenzene => 1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13720", "l": "2-C-methyl-D-erythritol 4-phosphate + NADP(+) <=> 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034191", "l": "apolipoprotein A-I receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12128", "l": "2 L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-oxoglutarate + 2 H(+) + L-glutamine + 2 reduced [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.4.7.1", "l": "\"Glutamate synthase (ferredoxin)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42848", "l": "8-demethyltetracenomycin C + dTDP-beta-L-rhamnose = 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + dTDP + H(+)"}, {"i": "EC:2.4.1.331", "l": "\"8-demethyltetracenomycin C L-rhamnosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050379", "l": "UDP-glucuronate 5'-epimerase activity"}, {"i": "MetaCyc:UDP-GLUCURONATE-5-EPIMERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008809", "l": "carnitine racemase activity"}, {"i": "MetaCyc:CARNRACE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0106018", "l": "phosphatidylinositol-3,5-bisphosphate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804276", "l": "ATM phosphorylates TTC5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17610", "l": "L-seryl-[sulfatase] + S-adenosyl-L-methionine => 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24193", "l": "(2R,4S)-2,4-diaminopentanoate + H2O + NADP(+) => (2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940007", "l": "MMP13 gene expression is stimulated by RUNX2:CBFB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55508", "l": "cucurbitadienol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 11-oxocucurbitadienol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.71", "l": "\"Cucurbitadienol 11-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17000", "l": "3'-phosphoadenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol <=> 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20630", "l": "H2O + O-phospho-L-seryl-[protein] => L-seryl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12872", "l": "(2E)-geranyl diphosphate <=> (4S)-limonene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202328", "l": "Translocation of PKC theta to plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52804", "l": "(2E,6E)-farnesyl diphosphate = (+)-eremophilene + diphosphate"}, {"i": "EC:4.2.3.164", "l": "\"(+)-eremophilene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52601", "l": "L-methionine + propanoyl-CoA => CoA + H(+) + N-propanoyl-L-methioninate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088152", "l": "FOXM1 stimulates CDC25A transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37647", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010681", "l": "PKC phosphorylates ROBO3.1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674019", "l": "BRAP binds KSR1:MARK3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937059", "l": "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44161", "l": "1D-myo-inositol 6-phosphate + H2O => myo-inositol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20348", "l": "[thioredoxin]-dithiol + NADP(+) <=> [thioredoxin]-disulfide + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12064", "l": "5-oxopentanoate + H2O + NAD(+) = glutarate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.20", "l": "\"Glutarate-semialdehyde dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692788", "l": "JUN positively regulates MAPK6 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53080", "l": "4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate = 4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36098", "l": "S-adenosyl-L-methionine + salicylate <=> methyl salicylate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.35"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69152", "l": "Removal of remaining Flap (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55459", "l": "ferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + sugiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102217", "l": "6-phosphoglucan, water dikinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34458", "l": "all-trans-beta-carotene <=> 9-cis-beta-carotene"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0050815", "l": "phosphoserine residue binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60314", "l": "H(+) + N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25619", "l": "diphosphate + terpentetriene => terpentedienyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392202", "l": "Dissociation of the P2Y purinoceptor 12:Gi complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0062037", "l": "D-loop DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.19"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848829", "l": "CBL autoubiquitinates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9737780", "l": "MTTP binds lomitapide (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043781", "l": "cobalt-factor II C20-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102277", "l": "2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose exo-beta-D-glucosaminidase activity"}, {"i": "MetaCyc:RXN-12544"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51387", "l": "hexadecanoyl-CoA + serotonin <=> CoA + H(+) + N-hexadecanoyl-serotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65697", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine => a diacylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51921", "l": "a quinone + AH2 => A + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49491", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate <=> 2-oxoglutarate + GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57841", "l": "1D-myo-inositol 1,3-bisphosphate + H2O => 1D-myo-inositol 1-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669023", "l": "TWEAK binds FN14 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43771", "l": "an alkylamine + L-glutaminyl-[protein] <=> N(5)-alkyl-L-glutaminyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380508", "l": "Translocation of NuMA to the centrosomes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033824", "l": "alternansucrase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.26"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54062", "l": "(2Z,6E)-hedycaryol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190682", "l": "Connexin synthesis (generic) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664397", "l": "IgG binds LPG1G2 in the amastigote form of Leishmania (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071535", "l": "RING-like zinc finger domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33530", "l": "acetyl-CoA + ergosta-5,7,22,24(28)-tetraen-3beta-ol <=> CoA + ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64812", "l": "acetyl-CoA + S-(2-aminoethyl)-homocysteine = CoA + H(+) + S-(2-acetamidoethyl)-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140704", "l": "3',2'-cyclic GMP-AMP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20951", "l": "3-sulfopyruvate + H(+) <=> CO2 + sulfoacetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784735", "l": "PCSK9:LDLR bind to Clathrin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14981", "l": "NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44328", "l": "1-octanoylglycerol + H2O = glycerol + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30316", "l": "1,7-dimethylxanthine + H(+) + NADH + O2 => 7-methylxanthine + formaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49060", "l": "a long-chain alkane + FMNH2 + O2 = a long chain fatty alcohol + FMN + H(+) + H2O"}, {"i": "EC:1.14.14.28", "l": "\"Long-chain alkane monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250264", "l": "TXNIP binds reduced thioredoxin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172666", "l": "RB1 binds condensin II (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2168923", "l": "Collagen type XVIII endostatin release (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0005436", "l": "sodium:phosphate symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49021", "l": "2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.40", "l": "\"Alpha-L-rhamnosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373707", "l": "Netrin-1 induced DCC clustering (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36015", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45348", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111930", "l": "Adenylate cyclase produces cAMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52155", "l": "(E)-2-(1H-indol-3-yl)-1-thioacetohydroximate + UDP-alpha-D-glucose <=> indolylmethyl-desulfoglucosinolate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937807", "l": "SRC phosphorylates RUNX3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212222", "l": "PRC2 recruits DNA methyltransferases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690152", "l": "USP5 cleaves polyubiquitin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000122", "l": "CD320 transports extracellular TCII:Cbl to endosome (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40720", "l": "an alkylcob(III)alamin + apo--[alkylcobalamin reductase] + glutathione => an S-substituted glutathione + cob(I)alamin--[alkylcobalamin reductase] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12209", "l": "4-methylumbelliferyl acetate + H2O => 4-methylumbelliferone + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672817", "l": "Active MTORC1 binds the ULK1 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31143", "l": "(3S)-hydroxyhexanoyl-CoA + NAD(+) = 3-oxohexanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848338", "l": "PNPLA4 hydrolyzes TAG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052758", "l": "coenzyme F420-dependent 2,4,6-trinitrophenol reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33577", "l": "a mannosylinositol-1-phosphophytoceramide + H2O => an inositol-1-phosphophytoceramide + beta-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.13", "l": "\"Gamma-D-glutamyl-L-lysine dipeptidyl-peptidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052791", "l": "3-deoxy-D-glycero-D-galacto-2-nonulosonic acid hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.2.-", "l": "\"Amidinotransferases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3296326", "l": "HCAR1 binds LACT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32901", "l": "2-endo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [flavodoxin] => 1,8-cineole + O2 + reduced [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2545253", "l": "Deacetylation of cohesin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202717", "l": "Heterodimerization of CEACAMs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35866", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008084", "l": "imaginal disc growth factor receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43919", "l": "(25R)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25R)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55957", "l": "(9Z)-octadecenoate + AH2 + O2 => (12R)-hydroxy-(9Z)-octadecenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690740", "l": "CD22 binds B-cell receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44329", "l": "1-octanoylglycerol + H2O => glycerol + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380224", "l": "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21516", "l": "isopiperitenone = piperitenone"}, {"i": "EC:5.3.3.11", "l": "\"Isopiperitenone Delta-isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168883", "l": "Haptoglobin:Hemoglobin binds CD163 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877153", "l": "STARD7 binds PC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24798", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O => (S)-2-amino-6-oxoheptanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661230", "l": "MT1A binds arsenic (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43124", "l": "guanosine(10) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.213", "l": "\"tRNA (guanine(10)-N(2))-dimethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23217", "l": "benzoyl-CoA + H(+) + NADPH + O2 => 3-hydroxybenzoyl-CoA + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40376", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + ATP => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21492", "l": "2,3-dihydroxybenzoate + H(+) = catechol + CO2"}, {"i": "EC:4.1.1.46", "l": "\"o-pyrocatechuate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61497", "l": "an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose => an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004796", "l": "thromboxane-A synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10283", "l": "1,7-dimethylxanthine + S-adenosyl-L-methionine <=> caffeine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54405", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O => 2-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865482", "l": "KMT2A (MLL) binds RUNX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798372", "l": "ATM phosphorylates DYRK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222662", "l": "Nitric oxide enters the bacterium (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202248", "l": "Phosphorylation of PLC-gamma1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964773", "l": "OXGR1 binds 2OG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51636", "l": "a quinone + H2O + selenite = a quinol + selenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48376", "l": "a neolactoside nLc4Cer + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38459", "l": "2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + a mycolipenoyl-CoA = 2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose + CoA"}, {"i": "EC:2.3.1.278", "l": "\"Mycolipenoyl-CoA--2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938887", "l": "PML binds RUNX1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848596", "l": "PTK6 binds PXN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626699", "l": "MARK4 binds ODF2 in the centriole (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33933", "l": "(3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal => all-trans-zeaxanthin + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51534", "l": "5-hydroxyisourate + H2O + NADP(+) => H(+) + NADPH + O2 + urate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19926", "l": "D-ribitol 5-phosphate + NAD(+) => D-ribulose 5-phosphate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853405", "l": "TPX2 binds AURKA at centrosomes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641206", "l": "RSPOs bind LGRs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42753", "l": "pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13171", "l": "fumarate => maleate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61489", "l": "cytidine(50) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(50) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65302", "l": "CO2 + H2O + succinate + verruculide A => 2-oxoglutarate + chrodrimanin C + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14740", "l": "CTP <=> 3',5'-cyclic CMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38974", "l": "O2 + octadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.99.-", "l": "\"With other acceptors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417908", "l": "P2RY1 binds ADP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654514", "l": "KAL1 binds FGFR1c (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37272", "l": "ATP + H2O + L-alanyl-L-glutamine(out) => ADP + H(+) + L-alanyl-L-glutamine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109701", "l": "PDPK1 binds PIP3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13676", "l": "[protein-PII]-L-tyrosine + UTP <=> [protein-PII]-uridylyl-L-tyrosine + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40211", "l": "(3S)-hydroxytetradecanedioyl-CoA + NAD(+) = 3-oxotetradecanedioyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64066", "l": "(R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH => (1R,2R)-pseudoephedrine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357483", "l": "RAC1 binds PAK1-3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033923", "l": "glucan 1,6-alpha-isomaltosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.2", "l": "\"Peptidyl-glycinamidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57773", "l": "3-nitrotoluene + NADH + O2 => 4-methylcatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052614", "l": "uracil oxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912727", "l": "CBL binds VAV (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390835", "l": "DRD1,5 bind DA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48007", "l": "1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 <=> 3,4-dimethoxybenzaldehyde + glycolaldehyde + guaiacol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6800793", "l": "PIDD1 translocates to the cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018747", "l": "phenanthrene-1,2-epoxide hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34731", "l": "15-methylhexadecasphing-4-enine + a fatty acyl-CoA = CoA + H(+) + N-acyl-15-methylhexadecasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102607", "l": "3beta-hydroxy-12,15-cassadiene-11-one 2-hydroxylase activity"}, {"i": "MetaCyc:RXN-15433"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8873946", "l": "OTUD3 deubiquitinates PTEN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14043", "l": "mandelonitrile + vicianose => (R)-vicianin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47209", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66707", "l": "H2O + mycophenolyl-CoA <=> CoA + H(+) + mycophenolate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54927", "l": "(7Z)-tetradecenoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxo-(9Z)-hexadecenoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44045", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => 11,12-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-434650", "l": "MATEs mediate extrusion of xenobiotics (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9698408", "l": "PTPRJ dephosphorylates active FLT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050014", "l": "ketotetrose-phosphate aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26147", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) <=> 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30837", "l": "NADP(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose => H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1878002", "l": "XYLTs transfer Xyl to core protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41004", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176973", "l": "Association of MCM8 with ORC:origin complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944225", "l": "Association of procollagen type XVII (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48474", "l": "ganglioside GD1a + N-acetylneuraminate => ganglioside GT1a + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56034", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102280", "l": "choline monooxygenase activity (NADP-dependent)"}, {"i": "MetaCyc:RXN-12582"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57016", "l": "3,6-dichloro-2-methoxybenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,6-dichlorosalicylate + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694583", "l": "ABHD4 hydrolyses NAPE (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12153", "l": "(3R,4S,5S,6R)-pentachlorocyclohexene => (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68688", "l": "CDC6 association with ORC:origin complexes mediated by MCM8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11801", "l": "H2O + NAD(+) => AMP + beta-nicotinamide D-ribonucleotide + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11979", "l": "anhydrotetracycline + H(+) + NADPH + O2 <=> 5a,11a-dehydrotetracycline + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62586", "l": "ADP + H(+) + L-tyrosine(in) + phosphate => ATP + H2O + L-tyrosine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102573", "l": "aminodeoxyfutalosine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013024", "l": "RHOB binds effectors at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.20"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38699", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052875", "l": "riboflavin reductase (NADH) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34843", "l": "7,8-dihydromonapterin 3'-triphosphate + 3 H2O = 7,8-dihydromonapterin + 2 H(+) + 3 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420977", "l": "Ca permeable AMPA receptor ligand binding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42201", "l": "corticosterone + NADP(+) => 11-dehydrocorticosterone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706340", "l": "Active FLT3:p-Y-GRB10 binds PIK3R1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693125", "l": "RHOF binds effectors at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51248", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1369052", "l": "ABCAs mediate lipid influx (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212642", "l": "L-Glutamine transport into neurons (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786789", "l": "FLT3LG dimer binds FLT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10668", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)"}, {"i": "EC:2.3.2.3", "l": "\"Lysyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004531", "l": "deoxyribonuclease II activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956639", "l": "RUNX1 binds YAP1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944240", "l": "Association of procollagen type III (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196026", "l": "Dab2 is recruited to the junctional plaques (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47092", "l": "(S)-2,3-dihydrodipicolinate + NADP(+) = dipicolinate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63117", "l": "peroxynitrite => nitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52633", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP => [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16876", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA <=> (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42206", "l": "11-dehydrocorticosterone + H(+) + NADH => corticosterone + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48008", "l": "2-hydroxybenzoyl-CoA + H(+) + NADH + O2 = 2,5-dihydroxybenzoyl-CoA + H2O + NAD(+)"}, {"i": "EC:1.14.13.209", "l": "\"Salicyloyl-CoA 5-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783552", "l": "OSM binds LIFR:JAKs,OSMR:JAKs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5617828", "l": "TRIP11:IFT20 dissociates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2152276", "l": "Secretion of transmembrane collagens (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56346", "l": "a 7-hydroxyisoflavone 7-O-beta-D-glucoside + H(+) + UDP => a 7-hydroxyisoflavone + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33942", "l": "H(+) + L-arginine + NADH + O2 <=> H2O + N(omega)-hydroxy-L-arginine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5229132", "l": "AP4 binds APP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050414", "l": "formimidoylaspartate deiminase activity"}, {"i": "RHEA:13661", "l": "H2O + N-formimidoyl-L-aspartate = N-formyl-L-aspartate + NH4(+)"}, {"i": "EC:3.5.3.5", "l": "\"Formimidoylaspartate deiminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662649", "l": "MT4 binds cadmium (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49452", "l": "a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H2O = 6-sulfo-D-quinovose + a 1,2-diacyl-sn-glycerol"}, {"i": "EC:3.2.1.199", "l": "\"Sulfoquinovosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60693", "l": "(E)-non-2-enal + H2O + NADP(+) => (E)-non-2-enoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.17", "l": "\"Inulin fructotransferase (DFA-I-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983161", "l": "Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40536", "l": "4 H(+) + narbomycin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + novapikromycin + 4 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-179417", "l": "Multiubiquitination of Nek2A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.28", "l": "\"Acrocylindropepsin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54209", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 => 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39549", "l": "(2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41879", "l": "(3R)-hydroxydodecanoyl-[ACP] <=> (2E)-dodecenoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693608", "l": "Initial resection of double-strand break ends (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20815", "l": "(3S)-citryl-CoA <=> acetyl-CoA + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20252", "l": "L-alanine <=> D-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31215", "l": "(5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+) = (5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875451", "l": "MET phosphorylates CBL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375133", "l": "Basigin binds Mannose-carrying cell recognition molecules (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703430", "l": "FLT3 fusions:GRB2 bind SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44494", "l": "3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-decaprenylbenzoate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592297", "l": "Full activation of MMP1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5323526", "l": "FRAT proteins bind GSK3beta (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39956", "l": "(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190245", "l": "FGFR1b binds to FGF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112037", "l": "Inactivation of PLC beta (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54979", "l": "(3S)-hydroxytetradecanoyl-CoA + H2O <=> (3S)-hydroxytetradecanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57276", "l": "a 2'-deoxyguanosine in DNA + glyoxal = an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37662", "l": "anthraniloyl-CoA + methanol <=> CoA + O-methyl anthranilate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730835", "l": "Autophosphorylation of PKC-theta (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043035", "l": "chromatin insulator sequence binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0019103", "l": "pyrimidine nucleotide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62861", "l": "acetyl-CoA + 7 H(+) + 7 malonyl-CoA => 7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + 7 CO2 + 8 CoA + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68826", "l": "Free CDT1 associates with CDC6:ORC:origin complexes (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18581", "l": "ethanolamine + H2O + O2 = glycolaldehyde + H2O2 + NH4(+)"}, {"i": "EC:1.4.3.8", "l": "\"Ethanolamine oxidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033219", "l": "urea binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603407", "l": "Activated NTRK3 binds PI3K (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352946", "l": "fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + glyceraldehyde 3-phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41686", "l": "1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + choline + H(+) => 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58650", "l": "H(+) + rifamycin SV ortho-naphthoquinone carboxamide => rifamycin SV hemiaminal"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0140319", "l": "receptor decoy activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008684", "l": "2-oxopent-4-enoate hydratase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0017081", "l": "chloride channel regulator activity"}, {"i": "REACT:R-HSA-383190", "l": "HCO3- transport through ion channel (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156699", "l": "Inactivation of Wee1 kinase (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20957", "l": "2-phenylacetate + ATP + CoA => AMP + diphosphate + phenylacetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41724", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R)-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41323", "l": "1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 2-acetyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983426", "l": "Capturing cargo and formation of prebudding complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16448", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone <=> daidzein + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854209", "l": "TBC1D10A binds JFC1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14084", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate <=> D-glyceraldehyde 3-phosphate + indole"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36486", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA <=> (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-517705", "l": "p-S318,221-HuR binds mRNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42106", "l": "(S)-2-hydroxypropylphosphonate + 5'-deoxyadenosine + cob(III)alamin + L-methionine => 2-hydroxyethylphosphonate + methylcob(III)alamin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59138", "l": "AMP + diphosphate + H(+) + N(5)-[(S)-citryl]-D-ornithine => ATP + citrate + D-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18738", "l": "ATP + H2O + hydrogenselenide => AMP + 2 H(+) + phosphate + selenophosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102070", "l": "18-hydroxyoleate peroxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156682", "l": "PLK1 phosphorylates NUDC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.4.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55693", "l": "an inositol-1-phosphoceramide + H2O => 1D-myo-inositol 1-phosphate + an N-acyl-sphingoid base + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43532", "l": "a ribonucleoside 3',5'-bisphosphate + H2O = a ribonucleoside 5'-phosphate + phosphate"}, {"i": "EC:3.1.3.97", "l": "\"3',5'-nucleoside bisphosphate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043956", "l": "3-hydroxypropionyl-CoA dehydratase activity"}, {"i": "RHEA:26518", "l": "3-hydroxypropanoyl-CoA = acryloyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8941895", "l": "Formation of CDK4/6:CCND complexes (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20345", "l": "[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH"}, {"i": "EC:1.8.1.9", "l": "\"Thioredoxin-disulfide reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2247511", "l": "STAB2:ligand is endocytosed (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40134", "l": "(9Z)-hexadecenoyl-CoA + H2O <=> (9Z)-hexadecenoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140628", "l": "outward rectifier potassium channel inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952128", "l": "RUNX3 binds TP53 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047837", "l": "D-xylose 1-dehydrogenase (NADP+) activity"}, {"i": "RHEA:22000", "l": "D-xylose + NADP(+) = D-xylono-1,5-lactone + H(+) + NADPH"}, {"i": "EC:1.1.1.179", "l": "\"D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634433", "l": "CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59295", "l": "beta-D-galactosyl-(1<->1')-N-octadecanoylsphing-4-enine + H2O <=> D-galactose + N-octadecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11692", "l": "NAD(+) + NADPH = NADH + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784959", "l": "BPHL hydrolyses VACV to ACV (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693761", "l": "FA2H hydroxylates CERA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187895", "l": "Engulfed CpG DNA binds to endosomal C-ter TLR9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23481", "l": "2-methylene-3-methylsuccinate => dimethylmaleate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52957", "l": "hyodeoxycholate + UDP-alpha-D-glucuronate => hyodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42450", "l": "(2E)-glutaconyl-CoA + H2O => (R)-2-hydroxyglutaryl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1606312", "l": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141423", "l": "Binding of the MCC complex to the APC/C complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264458", "l": "Proteasome mediated degradation of COP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693536", "l": "ATM phosphorylates MDC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2090079", "l": "GLB1 hydrolyses linker chain(2) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433542", "l": "Phosphorylation and activation of VAV1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60786", "l": "CO2 + gibberellin A25 + H(+) + succinate => 2-oxoglutarate + gibberellin A24 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801101", "l": "RABGGTA binds RABGGTB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21791", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65202", "l": "(4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + H(+) + H2O => S-(acetaldehyde)-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400063", "l": "Low conductance potassium channels in pancreatic beta cells open in response to epinephrine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63533", "l": "angiotensin I + H2O => angiotensin-(1-9) + L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.102", "l": "\"DNA primase AEP\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180591", "l": "Vpu:CD4 associates with beta-TrCP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008011", "l": "structural constituent of pupal chitin-based cuticle"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55091", "l": "24-methylene-24-dihydrolanosterol + S-adenosyl-L-methionine <=> (24Z)-ethylidenelanosterol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41704", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191299", "l": "Squalene is oxidized to its epoxide (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48997", "l": "3-methylcatechol + O2 => 2-hydroxy-6-oxo-2,4-heptadienoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66767", "l": "ATP + folate(in) + H2O <=> ADP + folate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18270", "l": "ethyl (S)-3-hydroxyhexanoate + NADP(+) => ethyl 3-oxohexanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855375", "l": "PTPN22 dissociates from CSK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112379", "l": "Recruitment of elongation factors to form elongation complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-622420", "l": "NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52165", "l": "O2 + phenylacetonitrile + reduced [NADPH--hemoprotein reductase] => (R)-mandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13903", "l": "N-(hydroxymethyl)urea + NH4(+) => H2O + N-(aminomethyl)urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55283", "l": "13-cis-retinol + tetradecanoyl-CoA <=> 13-cis-retinyl tetradecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52984", "l": "7-oxoheptanoyl-[ACP] + H2O + oxidized [flavodoxin] = 6-carboxyhexanoyl-[ACP] + reduced [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49441", "l": "(R)-2-hydroxy-4-methylpentanoate + 4-methylpentanoyl-CoA => (R)-2-hydroxy-4-methylpentanoyl-CoA + 4-methylpentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327733", "l": "FN1 binds Collagen types I-V, VII (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56460", "l": "H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51415", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> (8R)-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955794", "l": "PGP:Mg2+ dimer hydrolyses 3PG to glycerol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56065", "l": "3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose => 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31787", "l": "H2O + tuberculosinyl diphosphate = (13R)-edaxadiene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668714", "l": "RAC1:GTP binds NOX1 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27565", "l": "all-trans-nonaprenyl diphosphate + 7 diphosphate => (2E)-geranyl diphosphate + 7 isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20806", "l": "H(+) + hydrogencarbonate + NADH + propanoyl-CoA => 2-methyl-3-oxopropanoate + CoA + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444572", "l": "Zinc is an agonist of GPR39 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47716", "l": "4-pregnen-20,21-diol-3-one + NAD(+) = 21-hydroxyprogesterone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55333", "l": "a 3'-hydroxyflavone + S-adenosyl-L-methionine => a 3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41284", "l": "H2O + N-tetracosanoyl-sphing-4-enine => sphing-4-enine + tetracosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.31", "l": "\"L-aminoadipate-semialdehyde dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23323", "l": "D-tryptophan + malonyl-CoA <=> CoA + H(+) + N(2)-malonyl-D-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.125"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3321883", "l": "MSL acetylates histone H4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38876", "l": "uridine(2604) in 23S rRNA => pseudouridine(2604) in 23S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22986", "l": "N-carbamoyl-2-oxoglycine + phosphate => carbamoyl phosphate + oxamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48590", "l": "2 lipoxin B4 => 2 H2O + 2 leukotriene A4 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23164", "l": "a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose = a flavonol 7-O-beta-D-glucoside + H(+) + UDP"}, {"i": "EC:2.4.1.237", "l": "\"Flavonol 7-O-beta-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446634", "l": "IRAK4 is activated by autophosphorylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030624", "l": "U6atac snRNA binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030778", "l": "columbamine O-methyltransferase activity"}, {"i": "RHEA:15373", "l": "columbamine + S-adenosyl-L-methionine = H(+) + palmatine + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.118", "l": "\"Columbamine O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39390", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA <=> (2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34152", "l": "3-amino-2,3-dideoxy-scyllo-inosose + L-glutamine => 2-deoxystreptamine + 2-oxoglutaramate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047565", "l": "3-hydroxypropionate dehydrogenase (NAD+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-171106", "l": "LDLR:LDL complex => LDLR + LDL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964482", "l": "DREAM complex binds the E2F1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30394", "l": "4-methylsulfanyl-2-oxobutanoate + L-glutamine <=> 2-oxoglutaramate + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032021", "l": "RvT1-4 translocate from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-421831", "l": "trans-Golgi Network Coat Assembly (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47257", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-182988", "l": "Sprouty lures CBL away from EGFR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14152", "l": "luteolin 7-O-beta-D-glucuronide + UDP-alpha-D-glucuronate <=> H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55181", "l": "2-oxoglutarate + 3-methylnonanoyl-CoA + O2 => 2-hydroxy-3-methylnonanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38584", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O => a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788623", "l": "p-Y-STATs translocate to nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66265", "l": "ATP + H(+) + nonanoate => diphosphate + nonanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140037", "l": "sumo-dependent protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12950", "l": "D-fuconate => 2-dehydro-3-deoxy-D-fuconate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51204", "l": "6-trans-leukotriene B4 + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28599", "l": "H2O + N-acetyl-L-lysine => acetate + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46031", "l": "H2O2 + tetradecanoate <=> (2R)-hydroxytetradecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25924", "l": "A + H2O + quinolin-8-ol = 8-hydroxyquinolin-2(1H)-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788061", "l": "Fibronectin degradation by ADAM8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66504", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48660", "l": "8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64322", "l": "cholesteryl (9Z)-hexadecenoate + CoA => (9Z)-hexadecenoyl-CoA + cholesterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32273", "l": "4-methyl-2-oxopentanoate + CO2 + NADH => (2R,3S)-3-isopropylmalate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-560517", "l": "Expression of CD36 (platelet glycoprotein IV, FAT) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18302", "l": "ATP + NH4(+) + XMP => AMP + diphosphate + GMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035273", "l": "phthalate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32948", "l": "a 2-acylglycerol + an acyl-CoA => a 1,2-diacyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50616", "l": "NADP(+) + nonan-2-one = (3E)-nonen-2-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54184", "l": "an N-acyl-aromatic L-alpha-amino acid + H2O = a carboxylate + an aromatic L-alpha-amino acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39551", "l": "(2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH = (21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21725", "l": "a nitrile + 2 H2O => a carboxylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42747", "l": "guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210294", "l": "Interaction of PECAM-1 and SHP-2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28723", "l": "(S)-allantoin(in) + H(+)(in) = (S)-allantoin(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047345", "l": "ribose-5-phosphate adenylyltransferase activity"}, {"i": "MetaCyc:2.7.7.35-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975633", "l": "atROL binds to RBP2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2426569", "l": "Interaction of DAP12 and IREM2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34081", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + ATP => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14371", "l": "glycolate + phosphate => 2-phosphoglycolate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33324", "l": "a 1-acyl-sn-glycero-3-phosphate + tetradecanoyl-CoA => a 1-acyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30286", "l": "(-)-trans-permethrin + H2O <=> (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34720", "l": "15-methylhexadecasphing-4-enine 1-phosphate => (2E)-13-methyltetradecenal + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52621", "l": "3-methylbutanoyl-CoA => 2,2-dimethylpropanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63808", "l": "ATP + citrate + spermidine = AMP + diphosphate + H(+) + N(8)-citryl-spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200396", "l": "Creatine transport across the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50927", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 <=> (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374686", "l": "L1 interaction with Integrins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13354", "l": "4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol => 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132136", "l": "Vitronectin binds to C5b-C7 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-196857", "l": "PANK2 phosphorylates PanK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163798", "l": "Furin cleaves pro-protein Z to protein Z (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374681", "l": "L1 and NCAM1 engaged in cis-interaction (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40116", "l": "H2O + hexanoyl-CoA => CoA + H(+) + hexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209960", "l": "Diiodinated tyrosine can be deiodinated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50671", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19020", "l": "(6S)-NADHX + ATP <=> ADP + H(+) + NADH + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44078", "l": "AMP + diphosphate + pentadecanoyl-CoA => ATP + CoA + pentadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684006", "l": "KPNA2 translocates NBN to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210439", "l": "glutamate uptake by astrocytes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33168", "l": "2 a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycero-3-phospho-1D-myo-inositol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35022", "l": "L-threonine(in) <=> L-threonine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46415", "l": "a (7Z,10Z)-hexadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a (7Z,10Z,13Z)-hexadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944246", "l": "Association of procollagen type XXI (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43323", "l": "1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin <=> a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53828", "l": "2-oxoglutarate + a 5-hydroxymethyl-2'-deoxycytidine in DNA + O2 = a 5-formyl-2'-deoxycytidine in DNA + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0099103", "l": "channel activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0140587", "l": "chromatin loop anchoring activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12968", "l": "ATP + D-galacturonate <=> 1-phospho-alpha-D-galacturonate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0019194", "l": "sorbose transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027281", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58608", "l": "2 L-ascorbate + N-decanoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-decanoyl-(2S)-hydroxyglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58559", "l": "15alpha-stemmadenine intermediate II + H2O <=> (16S)-deshydroxymethyl-stemmadenine + formate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65283", "l": "alpha-NeuNAc-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1<->1')-L-Ser-[protein] + CMP-N-acetyl-beta-neuraminate <=> alpha-NeuNAc-(2->3)-beta-D-Gal-(1->3)-[alpha-NeuNAc-(2->6)]-alpha-D-GalNAc-(1<->1')-L-Ser-[protein] + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21500", "l": "UDP-alpha-D-glucose = H2O + UDP-4-dehydro-6-deoxy-alpha-D-glucose"}, {"i": "EC:4.2.1.76", "l": "\"UDP-glucose 4,6-dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19698", "l": "11-cis-retinyl hexadecanoate + H2O => 11-cis-retinol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0050499", "l": "oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor"}, {"i": "EC:1.20.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54731", "l": "acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] <=> malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.25.1", "l": "\"Deoxyribonuclease (pyrimidine dimer)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199425", "l": "PHLPP dephosphorylates S473 in AKT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25171", "l": "6-hydroxyhexan-6-olide <=> 6-oxohexanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14223", "l": "H(+) + methanol + sulfate => H2O + monomethyl sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27775", "l": "2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29626", "l": "alpha-maltopentaose + beta-maltose <=> alpha-maltohexaose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27671", "l": "1D-myo-inositol 1-phosphate + H2O => myo-inositol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730841", "l": "Phosphorylation and activation of VAV (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58406", "l": "H(+) + hexanal + NADPH => hexan-1-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39866", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol <=> 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.22", "l": "\"Carbazole 1,9a-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23595", "l": "glycerol + NADP(+) <=> D-glyceraldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31589", "l": "(Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+) => FMNH2 + NADH + O2 + uracil"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668404", "l": "TNFA binds TNFR2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357432", "l": "AXL binds SRC-1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.31", "l": "\"Scytalidopepsin A\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928617", "l": "EPHB2 binds KALRN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62014", "l": "5-methylcytidine(2499) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(2499) in 23S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061503", "l": "tRNA threonylcarbamoyladenosine dehydratase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871226", "l": "RET binds GFRA1,GFRA2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14210", "l": "alpha-D-galactose 1-phosphate + H(+) + UTP => diphosphate + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046933", "l": "proton-transporting ATP synthase activity, rotational mechanism"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809707", "l": "MTMR12 binds MTMR2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-507870", "l": "Aquaporins passively transport water out of cells (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54242", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72621", "l": "Ribosomal scanning  (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60351", "l": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852324", "l": "GTSE1 binds PLK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13123", "l": "3-phosphoshikimate + ADP + H(+) => ATP + shikimate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23093", "l": "H(+) + H2O + hydroxyatrazine => ethylamine + N-isopropylammelide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3222093", "l": "BRD7 binds TP53 and EP300 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43207", "l": "cytidine(1409) in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(1409) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000319", "l": "BORA binds PLK1 and AURKA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19778", "l": "A + L-pipecolate => AH2 + H(+) + L-1-piperideine-6-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5213464", "l": "RIPK1 is phosphorylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60807", "l": "2-oxoglutarate + gibberellin A19 + O2 <=> CO2 + gibberellin A17 + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48212", "l": "a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-532549", "l": "MPI isomerises Fru6P to Man6P (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0019105", "l": "N-palmitoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102936", "l": "gypsogenate-UDP-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-9013"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59356", "l": "H2O + lactobiono-1,5-lactone = H(+) + lactobionate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0070853", "l": "myosin VI binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13592", "l": "3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate <=> ADP + H(+) + phosphate + trans-3-methylglutaconyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40624", "l": "H2O + tritetradecanoylglycerol => 2,3-ditetradecanoyl-sn-glycerol + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032141", "l": "single cytosine insertion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56125", "l": "A + all-trans-lycopene + dimethylallyl diphosphate + H2O => AH2 + diphosphate + nonaflavuxanthin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28853", "l": "melibiose(out) + Na(+)(out) => melibiose(in) + Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211467", "l": "HNF1A-dependent synthesis of HNF4G protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36397", "l": "cholesta-5,7,24-trien-3beta-ol + H(+) + NADPH => cholesta-5,7-dien-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18378", "l": "ATP + streptomycin => ADP + H(+) + streptomycin 3''-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33920", "l": "H(+) + lanosterol + NADPH => 24,25-dihydrolanosterol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1297444", "l": "Binding of cAMP to HCN channels (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013021", "l": "GDIs block activation of RHOB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16075", "l": "CO2 + dialkyl ketone + L-alanine => 2,2-dialkylglycine + H(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25587", "l": "alpha-L-rhamnose <=> beta-L-rhamnose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032036", "l": "LTA4 translocates from neutrophil cytosol to platelet cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102347", "l": "trans-arachidon-2-enoyl-CoA reductase activity"}, {"i": "MetaCyc:RXN-13306"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788061", "l": "Fibronectin degradation by ADAM8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57127", "l": "2-oxoglutaramate <=> 2-hydroxy-5-oxoproline"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015117", "l": "thiosulfate transmembrane transporter activity"}, {"i": "RHEA:32807", "l": "thiosulfate(in) = thiosulfate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22291", "l": "an oligoglycosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O <=> an N-acyl-sphingoid base + an oligoglycosyl-(1->4)-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507871", "l": "Aquaporins passively transport glycerol out of cells (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005049", "l": "nuclear export signal receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8979071", "l": "KDM6B binds iron (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445714", "l": "Aquaporin-3 passively transports water out of cell (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52651", "l": "H2O + L-arabino-1,4-lactone 5-phosphate <=> 5-phospho-L-arabinonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648089", "l": "NEK6 and NEK7 phosphorylate EML4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227860", "l": "ITCH homolog downregulates MDA5/IPS1 signaling   (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42899", "l": "L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951499", "l": "Loading of antigenic peptides on to class I MHC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103117", "l": "UDP-3-O-acyl-N-acetylglucosamine deacetylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373734", "l": "Nephrin interacts with Podocin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027531", "l": "Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15799", "l": "biliverdin IXalpha + H(+) + NADH => bilirubin IXalpha + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607058", "l": "Activated protein C:PROCR binds F2R (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605724", "l": "Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55973", "l": "acetyl-CoA + ethanol => CoA + ethyl acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015658", "l": "branched-chain amino acid transmembrane transporter activity"}, {"i": "REACT:R-HSA-9672770", "l": "SLC25A44 transports Leu, Ile and Val from cytosol to mitochondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018582", "l": "1-hydroxy-2-naphthoate 1,2-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61226", "l": "2-oxosuccinamate + H2O2 + NH4(+) => H2O + L-asparagine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32662", "l": "(6E)-8-hydroxygeraniol + 2 NADP(+) <=> (6E)-8-oxogeranial + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102767", "l": "flavanone 4'-O-methyltransferase activity"}, {"i": "RHEA:31743", "l": "a 4'-hydroxyflavanone + S-adenosyl-L-methionine = a 4'-methoxyflavanone + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.231", "l": "\"Flavonoid 4'-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54563", "l": "an adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + GTP <=> a 5'-triphospho-guanosine-ribonucleotide-tRNA(His) + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49390", "l": "H(+) + UDP + validamycin A => UDP-alpha-D-glucose + validoxylamine A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110244", "l": "Excision of FapyG by OGG1 glycosylase (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693540", "l": "MRN activates ATM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617194", "l": "Phospho-STAT3 binds the promoter of the CEBPB gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654514", "l": "KAL1 binds FGFR1c (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395764", "l": "atREs binds to nascent CM (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190265", "l": "FGFR4 binds to FGF (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69068", "l": "RFC dissociates after sliding clamp formation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42792", "l": "cholesterol + hexadecanoyl-CoA = cholesteryl hexadecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18948", "l": "2-oxoglutarate + L-prolyl-[collagen] + O2 <=> CO2 + succinate + trans-4-hydroxy-L-prolyl-[collagen]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28419", "l": "(R)-carnitine + gamma-butyrobetainyl-CoA => (R)-carnitinyl-CoA + 4-(trimethylamino)butanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047955", "l": "glycerol dehydrogenase (acceptor) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6813626", "l": "LEAP2 binds bacteria (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28234", "l": "L-glutamate 5-semialdehyde = (S)-1-pyrroline-5-carboxylate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.23"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014454", "l": "RHOG translocates to the ER membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47740", "l": "1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate = CO2 + demethylphylloquinone + diphosphate"}, {"i": "EC:2.5.1.130", "l": "\"2-carboxy-1,4-naphthoquinone phytyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32545", "l": "1,8-cineole + diphosphate => (2E)-geranyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693061", "l": "STAMBP binds STAM (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33128", "l": "H2O + salicin-6-phosphate => beta-D-glucose 6-phosphate + salicyl alcohol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694409", "l": "Nucleotide exchange on RAB1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20819", "l": "3alpha-hydroxyglycyrrhetinate + NADP(+) <=> 3-oxoglycyrrhetinate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32856", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686657", "l": "ERCC1:XPF cleaves flaps generated by SSA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13282", "l": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) => 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22647", "l": "O2 + protopine + reduced [NADPH--hemoprotein reductase] <=> 6-hydroxyprotopine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003938", "l": "IMP dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944220", "l": "Association of procollagen type XXIII (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052789", "l": "mannan 1,3-beta-mannosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17293", "l": "2 H(+) + NADH + O2 + precorrin-3A = H2O + NAD(+) + precorrin-3B"}, {"i": "EC:1.14.13.83", "l": "\"Precorrin-3B synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004747", "l": "ribokinase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050608", "l": "vanillin dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015425", "l": "ATPase-coupled nonpolar-amino acid transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202248", "l": "Phosphorylation of PLC-gamma1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64957", "l": "dTTP + 2 H2O => dTMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2255343", "l": "RAB8A,10,13,14 exchange GDP for GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374664", "l": "Phosphorylation and activation of Ezrin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52661", "l": "an L-alpha-amino acid + ATP + holo-[ACP] => AMP + an L-alpha-aminoacyl-[ACP] + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54867", "l": "H(+) + NADPH + O2 + sulcatone <=> 4-methylpent-3-en-1-yl acetate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656261", "l": "Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980042", "l": "NOTCH1 binds JAG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64242", "l": "CoA + H(+) + N-octanoylglycine => glycine + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42060", "l": "11-cis-retinol + NAD(+) = 11-cis-retinal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613476", "l": "EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40101", "l": "1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17947", "l": "(1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50611", "l": "leukotriene B4 + NADP(+) <=> 12-oxo-leukotriene B4 + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43004", "l": "H(+) + O-carbamoyl-L-serine = 2-aminoprop-2-enoate + CO2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64447", "l": "L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71783", "l": "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013963", "l": "RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990381", "l": "ubiquitin-specific protease binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21180", "l": "1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol = D-glucose + indole-3-acetyl-1D-myo-inositol"}, {"i": "EC:2.3.1.72", "l": "\"Indoleacetylglucose--inositol O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218642", "l": "PTK2 autophosphorylates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016519", "l": "gastric inhibitory peptide receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22024", "l": "H2O + NAD(+) + trimethylamine = 2 H(+) + NADH + trimethylamine N-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32407", "l": "(1R,2S,4S)-neoisodihydrocarveol + NAD(+) = (1R,4S)-isodihydrocarvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54028", "l": "a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016596", "l": "thienylcyclohexylpiperidine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60950", "l": "(S)-homoeriodictyol + H(+) + S-adenosyl-L-homocysteine => (S)-eriodictyol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043799", "l": "glycine oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174124", "l": "Dephosphorylation of phospho-Cdh1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20376", "l": "ATP + CoA + propanoate <=> AMP + diphosphate + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51606", "l": "4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20455", "l": "H(+) + scopolin + UDP => scopoletin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047161", "l": "tartronate O-hydroxycinnamoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40148", "l": "eicosanoyl-CoA + H2O => CoA + eicosanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47443", "l": "(3S)-hydroxy-(7Z-hexadecenoyl)-CoA + NAD(+) <=> 3-oxo-(7Z-hexadecenoyl)-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015394", "l": "uridine:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627107", "l": "XIAP binds CASP7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632648", "l": "SMURF1/2 ubiquitinates PTCH1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18321", "l": "2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate"}, {"i": "EC:2.6.1.6", "l": "\"Leucine transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29132", "l": "menaquinol-8 + nitrate => H2O + menaquinone-8 + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25031", "l": "ADP-D-ribose + phosphate => ADP-D-ribose 1''-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58509", "l": "(3Z)-2-oxo-4-carboxy-3-hexenedioate + H2O => (2S)-2-hydroxy-4-oxobutane-1,2,4-tricarboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033520", "l": "TYSND1 cleaves TYSND1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64294", "l": "(3R)-3,8,9,10-tetrahydroxy-6-methyl-1,2,3,4-tetrahydroanthracen-1-one + NADP(+) => 3,8,9,10-tetrahydroxy-6-methyl-1,4-dihydroanthracen-1-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164381", "l": "G alpha (s) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25112", "l": "H2O + pyridoxine 5'-phosphate = phosphate + pyridoxine"}, {"i": "EC:3.1.3.74", "l": "\"Pyridoxal phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730847", "l": "Hydrolysis of PIP2 by PLCG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8873923", "l": "STARD10 binds LPCAT1 and PC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30759", "l": "5-methylcytosine + H(+) + H2O = NH4(+) + thymine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008577", "l": "IL37:IL18R1 binds SIGIRR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29333", "l": "fumarate(out) + 2 H(+)(out) => fumarate(in) + 2 H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928614", "l": "EFNB:GRB4 binds GIT1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33911", "l": "an N-alkylglycine + H2O + O2 = an alkylamine + glyoxylate + H2O2"}, {"i": "EC:1.5.3.20", "l": "\"N-alkylglycine oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692781", "l": "p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668335", "l": "CHMP7 binds LEMD2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353273", "l": "Elongation by Pol zeta complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685607", "l": "Sialic acid binds SIGLEC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36137", "l": "(E)-hexadec-2-enoate + 2 H(+) + NADH => (2E)-hexadecenal + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54271", "l": "2-oxoglutarate + L-asparaginyl-[hypoxia-inducible factor alpha subunit] + O2 <=> (3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha subunit] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47176", "l": "(2R)-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21252", "l": "(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2"}, {"i": "EC:1.1.99.2", "l": "\"L-2-hydroxyglutarate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985591", "l": "SLIT2-bound ROBO1 binds MYO9B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050700", "l": "CARD domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5686578", "l": "Activated ATM phosphorylates ABL1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54845", "l": "H(+) + hexan-3-one + NADPH + O2 => ethyl butanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052850", "l": "NADPH-dependent dihydrocurcumin reductase activity"}, {"i": "MetaCyc:RXN0-6677"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626982", "l": "TNF-alpha:TNFR1:NSMAF binds GNB2L1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789109", "l": "Superoxide anion reacts with Fe-S cluster (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005147", "l": "oncostatin-M receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400342", "l": "Expression of ARNTL (BMAL1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139893", "l": "Granzyme-B activates BID by cleavage (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28790", "l": "4-hydroxy-L-threonine + ATP <=> 4-(phosphooxy)-L-threonine + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55762", "l": "an N(2)-[(3R)-3-(acyloxy)acyl]-L-ornithine lipid + holo-[ACP] => a fatty acyl-[ACP] + a lyso-ornithine lipid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59332", "l": "1'-hydroxy-gamma-carotene + A = 1'-hydroxytorulene + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851011", "l": "TRIM27 polyubiquitinates PTEN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034915", "l": "2-methylhexanoyl-CoA C-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71445", "l": "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48406", "l": "adenosine 3',5'-bisphosphate + H(+) + holo-[EntB isochorismatase/aryl-carrier protein] => apo-[EntB isochorismatase/aryl-carrier protein] + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6794347", "l": "Homer1,2,3 dimerizes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36765", "l": "beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15593", "l": "amicoumacin A 2-phosphate + H2O = amicoumacin A + phosphate"}, {"i": "EC:3.1.3.107", "l": "\"Amicoumacin phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36692", "l": "octadecanoyl-CoA + sphing-4-enine => CoA + H(+) + N-octadecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24172", "l": "A + a 3-oxo-5beta-steroid = a 3-oxo-Delta(4)-steroid + AH2"}, {"i": "EC:1.3.99.6", "l": "\"3-oxo-5-beta-steroid 4-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15787", "l": "2-aminophenoxazin-3-one + AH2 => 2 6-iminocyclohexa-2,4-dienone + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21644", "l": "ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate"}, {"i": "EC:2.7.1.30", "l": "\"Glycerol kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685639", "l": "Synthesis of SARS-CoV-1 minus strand subgenomic mRNAs by template switching (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64765", "l": "S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine => 2-aminoprop-2-enoate + 3-methyl-3-sulfanylhexan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5226979", "l": "ADD1:ADD2 binds DMTN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18021", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) = CMP + ganglioside GD1a (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55488", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-cassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13031", "l": "H(+) + H2O2 + N-acetyl-D-glucosaminate => H2O + N-acetyl-D-glucosamine + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102847", "l": "1-18:3-2-16:2-monogalactosyldiacylglycerol desaturase activity"}, {"i": "MetaCyc:RXN-8309"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635861", "l": "NUMB:ITCH binds GLI1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24537", "l": "L-tryptophan + O2 => N-formyl-L-kynurenine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004338", "l": "glucan exo-1,3-beta-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30425", "l": "(+)-delta-selinene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39553", "l": "(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+) => (2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32279", "l": "allantoate + 2 H(+) + 2 H2O = (S)-ureidoglycolate + CO2 + 2 NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671919", "l": "Activated CIT phosphorylates MRLCs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866321", "l": "VLDL binds APOC1 and APOC4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54342", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56890", "l": "UDP-4-dehydro-beta-L-rhamnose => UDP-4-dehydro-6-deoxy-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37580", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2545196", "l": "FN1 dimerizes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51703", "l": "S-adenosyl-L-methionine + xanthogalenol <=> 4'-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28417", "l": "gamma-L-glutamylputrescine + H2O + O2 <=> 4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48670", "l": "20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 20-hydroxy-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015158", "l": "raffinose transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102697", "l": "trans-zeatin-O-glucoside UDP glycosyltransferase activity"}, {"i": "MetaCyc:RXN-4736"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22973", "l": "butanal + CoA + NADP(+) => butanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982807", "l": "JAK2 phosphorylation of GHR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61250", "l": "3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+) => H2O + L-tyrosine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25437", "l": "(2E,6E)-farnesyl diphosphate => (E,R)-alpha-bisabolene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57965", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17412", "l": "(S)-coclaurine + S-adenosyl-L-methionine <=> (S)-N-methylcoclaurine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605797", "l": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54556", "l": "5'-end ribonucleotide-tRNA(His) + ATP + H(+) = an adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34883", "l": "ATP + H2O + selenate(out) = ADP + H(+) + phosphate + selenate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43172", "l": "guanosine(1575) in yeast 18S rRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(1575) in yeast 18S rRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.309", "l": "\"18S rRNA (guanine(1575)-N(7))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14045", "l": "1-carboxyvinyl carboxyphosphonate + H(+) = 3-(hydrohydroxyphosphoryl)pyruvate + CO2"}, {"i": "EC:2.7.8.23", "l": "\"Carboxyvinyl-carboxyphosphonate phosphorylmutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53922", "l": "ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein] => ATP + L-threonyl-[Fas-activated protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58595", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53010", "l": "di-trans,poly-cis-polyprenyl diphosphate + n diphosphate => (2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20082", "l": "H2O + N-methylhexanamide => hexanoate + methylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58403", "l": "heptan-1-ol + NADP(+) <=> H(+) + heptanal + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64691", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32297", "l": "2 diphosphate + NADP(+) + squalene => 2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005497", "l": "androgen binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-901047", "l": "Binding of ERp57 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465924", "l": "OPN1LW binds 11cRAL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034527", "l": "1,2-dihydroxy-8-carboxynaphthalene dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62270", "l": "3-methyl-2-oxobutanoate + H(+) + NADPH => (R)-2-hydroxy-3-methylbutyrate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948709", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47383", "l": "(25R)-3beta-hydroxycholest-5-en-7-one-26-al + H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta-hydroxycholest-5-en-7-one-26-oate + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1362465", "l": "GHBP binds GHR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202459", "l": "Phosphorylation of Bcl10 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15745", "l": "[(2->1)-beta-D-fructosyl](n) + sucrose = [(2->1)-beta-D-fructosyl](n+1) + D-glucose"}, {"i": "EC:2.4.1.9", "l": "\"Inulosucrase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052693", "l": "epoxyqueuosine reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15390", "l": "ATP => 3',5'-cyclic AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55847", "l": "calcidiol + UDP-alpha-D-glucuronate <=> calcidiol 3-O-(beta-D-glucuronide) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034847", "l": "naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55354", "l": "13-cis-retinol => all-trans-retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69116", "l": "Formation of Okazaki fragments (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805022", "l": "USP2 binds the heterodimer of MDM2 and MDM4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879910", "l": "JAK2 is phosphorylated, activated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.110"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41556", "l": "2-oxoglutarate + L-arginyl-[ribosomal protein uL16] + O2 = (3R)-3-hydroxy-L-arginyl-[ribosomal protein uL16] + CO2 + succinate"}, {"i": "EC:1.14.11.47", "l": "\"[50S ribosomal protein L16]-arginine 3-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25590", "l": "(S)-oxalosuccinate + H(+) + NADPH => D-threo-isocitrate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46760", "l": "2,4-dinitrotoluene + NADH + O2 = 4-methyl-5-nitrocatechol + NAD(+) + nitrite"}, {"i": "EC:1.14.12.24", "l": "\"2,4-dinitrotoluene dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786190", "l": "CMBL hydrolyses OM to OLMS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42180", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031829", "l": "type 4 serotonin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47594", "l": "CMP + ganglioside GP1c (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E))"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13766", "l": "bromochloromethane + H2O => bromide + chloride + formaldehyde + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37181", "l": "(6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62298", "l": "(+)-malbrancheamide + 2 FADH2 => (+)-premalbrancheamide + 2 chloride + 2 FAD + 4 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211950", "l": "CYP24A1 24-hydroxylates CTL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047683", "l": "aryl-aldehyde dehydrogenase (NADP+) activity"}, {"i": "RHEA:19229", "l": "AMP + an aromatic aldehyde + diphosphate + NADP(+) = an aromatic carboxylate + ATP + H(+) + NADPH"}, {"i": "EC:1.2.1.30", "l": "\"Carboxylate reductase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18832", "l": "4-phospho-D-erythronate + NAD(+) <=> (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20958", "l": "AMP + diphosphate + phenylacetyl-CoA => 2-phenylacetate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48824", "l": "GDP-beta-L-fucose + Lc4Cer = a lactoside III(4)-a-Fuc-Lc4Cer + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803890", "l": "SFN dimerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0034739", "l": "histone deacetylase activity (H4-K16 specific)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030783", "l": "[cytochrome c]-methionine S-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990055", "l": "phenylacetaldehyde synthase activity"}, {"i": "RHEA:55532", "l": "H(+) + H2O + L-phenylalanine + O2 = 2-phenylacetaldehyde + CO2 + H2O2 + NH4(+)"}, {"i": "EC:4.1.1.109", "l": "\"Phenylacetaldehyde synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018751", "l": "3,5-dichlorophenylcarboximide hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944214", "l": "Association of procollagen type I (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10810", "l": "(1R,2S)-epoxypropylphosphonate + 2 H2O => (S)-2-hydroxypropylphosphonate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19958", "l": "2 5'-dehydroinosine + O2 => 2 9-riburonosylhypoxanthine + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204485", "l": "Basigin binds CyPA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399934", "l": "Phosphorylation of Plexin-A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454916", "l": "The ABCC family mediates organic anion transport (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195304", "l": "Association of beta-catenin with the destruction complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008412", "l": "CDK4 phosphorylates RUNX2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17792", "l": "(S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine <=> (S)-reticuline + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24117", "l": "(2E)-geranyl diphosphate + H2O => (S)-linalool + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451311", "l": "Activation of Ca-permeable Kainate receptors (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729330", "l": "SRPK1/2 phosphorylates nucleoprotein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350058", "l": "Formation of CSL NCOR corepressor complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130504", "l": "Cleavage of lip22 to lip10 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981926", "l": "RAC1 and CDC42 activate PAK3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64357", "l": "2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 => (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13692", "l": "diphosphate + glycerol <=> glycerol 1-phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34258", "l": "sporulenol <=> (R)-tetraprenyl-beta-curcumene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42093", "l": "all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20217", "l": "H(+) + trimethylamine N-oxide = dimethylamine + formaldehyde"}, {"i": "EC:4.1.2.32", "l": "\"Trimethylamine-oxide aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43444", "l": "1,2-ditetradecanoyl-sn-glycerol + ATP = 1,2-ditetradecanoyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021945", "l": "MECP2 binds GAMT gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33922", "l": "H(+) + lanosterol + NADPH <=> 24,25-dihydrolanosterol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52600", "l": "L-methionine + propanoyl-CoA = CoA + H(+) + N-propanoyl-L-methioninate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008326", "l": "RUNX2 binds HDAC4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51526", "l": "magnoflorine + S-adenosyl-L-homocysteine => (S)-corytuberine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800870", "l": "NDUF subunits bind to form the FP subcomplex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52737", "l": "3'-phosphoadenylyl sulfate + indolylmethyl-desulfoglucosinolate => adenosine 3',5'-bisphosphate + glucobrassicin + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18174", "l": "(2R)-1-(4-hydroxyphenyl)-2-aminoethanol => (4-hydroxyphenyl)acetaldehyde + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25789", "l": "4-hydroxy-2-oxoheptanedioate => pyruvate + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005225", "l": "volume-sensitive anion channel activity"}, {"i": "REACT:R-HSA-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39647", "l": "AH2 + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + S-adenosyl-L-methionine = 5'-deoxyadenosine + A + dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + H(+) + L-methionine + NH4(+)"}, {"i": "EC:4.3.1.30", "l": "\"dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53425", "l": "a fatty acyl-CoA + a sphingoid base => an N-acyl-sphingoid base + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47965", "l": "H2O + N(pros)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102793", "l": "soyasapogenol B glucuronosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41385", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004913", "l": "interleukin-4 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9647994", "l": "RAS proteins are depalmitoylated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21227", "l": "CDP-choline + sphing-4-enine <=> CMP + H(+) + sphing-4-enine-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042800", "l": "histone methyltransferase activity (H3-K4 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856525", "l": "ANGPTL8 binds ANGPTL3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52567", "l": "2-dehydro-L-erythronate <=> 3-dehydro-L-erythronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372559", "l": "aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.52"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247922", "l": "GGCT transforms gGluCys to OPRO (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45675", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14657", "l": "aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate"}, {"i": "EC:5.3.1.6", "l": "\"Ribose-5-phosphate isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2262775", "l": "Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23376", "l": "L-threonate + NAD(+) = 3-dehydro-D-erythronate + H(+) + NADH"}, {"i": "EC:1.1.1.129", "l": "\"L-threonate 3-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687107", "l": "MAPK4,6 translocate to nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64175", "l": "L-altrarate <=> galactarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55003", "l": "3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35038", "l": "4-aminobutanoate(in) <=> 4-aminobutanoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44602", "l": "a fatty acyl-AMP + diphosphate => a fatty acid + ATP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54169", "l": "a 5'-(N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine => a 5'-(N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49959", "l": "5,10-dihydrophenazine 1-carboxylate + O2 <=> H2O2 + phenazine-1-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22207", "l": "3-hydroxyphenylacetate + H(+) + NADPH + O2 <=> H2O + homogentisate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43521", "l": "2-carboxy-5-(dihydroxymethyl)furan + O2 => 2,5-dicarboxyfuran + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63606", "l": "[Pyr1]apelin-12 + L-phenylalanine => [Pyr1]apelin-13 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19514", "l": "carbamoyl phosphate + L-ornithine => H(+) + L-citrulline + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46758", "l": "a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51377", "l": "dopamine + hexadecanoyl-CoA => CoA + H(+) + N-hexadecanoyl-dopamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665278", "l": "Resistant ERBB2 KD mutants do not bind AEE788 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604553", "l": "HEY2 gene expression is stimulated by NOTCH4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-448632", "l": "IL34 dimerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033789", "l": "phenylacetyl-CoA dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40445", "l": "6-deoxy-6-sulfo-D-fructose 1-phosphate + ADP + H(+) => 6-deoxy-6-sulfo-D-fructose + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37229", "l": "(E)-1,3-pentadiene + CO2 => (E,E)-sorbate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36956", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + pentadecanoyl-CoA => (9Z)-pentadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12341", "l": "L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] => H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411373", "l": "NLK translocates to nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186773", "l": "PDGF dimer binds two receptors simultaneously (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16834", "l": "2 glutathione + H2O2 => glutathione disulfide + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690414", "l": "SRY and NR5A1 (SF1) bind SOX9 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17638", "l": "squalene => hop-22(29)-ene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21798", "l": "dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH => dTDP-beta-L-rhamnose + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112266", "l": "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24540", "l": "A + D-glucose = AH2 + D-glucono-1,5-lactone"}, {"i": "EC:1.1.99.35", "l": "\"Soluble quinoprotein glucose dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20968", "l": "L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H2O"}, {"i": "EC:4.2.1.25", "l": "\"L-arabinonate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102298", "l": "selenocystathione synthase activity"}, {"i": "MetaCyc:RXN-12728"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52835", "l": "1-hydroxylimonen-2-one + H(+) + NADPH + O2 <=> 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20736", "l": "acetyl-CoA + glycine = (2S)-2-amino-3-oxobutanoate + CoA"}, {"i": "EC:2.3.1.29", "l": "\"Glycine C-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49973", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418456", "l": "cGMP is degraded by PDEs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38308", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26507", "l": "(9Z)-octadecenamide + H2O => (9Z)-octadecenoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5140741", "l": "WNT5A binds FZD and ROR receptors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24098", "l": "H(+) + isoscoparin + S-adenosyl-L-homocysteine => isoorientin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629154", "l": "NEIL1 recognizes and binds thymine glycol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052906", "l": "tRNA (guanine(37)-N(1))-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191830", "l": "snRNP nuclear import and release (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879274", "l": "acetylglucosamine-inositol-phosphate is dephosphorylated (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58177", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADPH => all-trans-lycopaoctaene + 2 diphosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51057", "l": "A + androst-4-ene-3,17-dione => AH2 + androsta-1,4-diene-3,17-dione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62720", "l": "3 H(+) + 3 NADPH + 3 O2 + probetaenone I = betaenone B + 3 H2O + 3 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37688", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21006", "l": "2-dehydropantolactone + AH2 => (R)-pantolactone + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26169", "l": "3-fumarylpyruvate + H2O => fumarate + H(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29298", "l": "aldehydo-D-galacturonate(out) + H(+)(out) <=> aldehydo-D-galacturonate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25783", "l": "H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine <=> 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10910", "l": "adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate => 3'-phosphoadenylyl sulfate + glycolithocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40732", "l": "(20S)-ginsenoside Rg3 + 2 H2O => (20S)-protopanaxadiol + 2 D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46317", "l": "GDP-N,N'-diacetylbacillosamine + H2O => 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67006", "l": "a 5'-end diphospho-ribonucleoside in mRNA + H(+) + phosphate => a 5'-end triphospho-ribonucleoside in mRNA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-164834", "l": "Enzyme-bound ATP is released (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34575", "l": "2 H(+) + O2 + pentalenolactone F + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalenolactone"}, {"i": "EC:1.14.19.8", "l": "\"Pentalenolactone synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871370", "l": "p-Y281,292-RUFY1 translocates from cytosol to early endosome membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38171", "l": "hexadecane-1,2-diol + hexadecanoyl-CoA = 2-hydroxyhexadecyl hexadecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62940", "l": "H2O + N(4)-acetylcytosine = acetate + cytosine + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030273", "l": "melanin-concentrating hormone receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44875", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9007447", "l": "E2F6 forms the PRC1L4 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22630", "l": "(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate => 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071820", "l": "N-box binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507871", "l": "Aquaporins passively transport glycerol out of cells (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856157", "l": "LAG3 (CD233) binds MHC II (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37043", "l": "ATP + H2O + L-alanyl-L-glutamate(out) = ADP + H(+) + L-alanyl-L-glutamate(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090369", "l": "ornithine carbamoyltransferase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58380", "l": "NADP(+) + nonan-1-ol = H(+) + NADPH + nonanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11813", "l": "H2O + methanethiol + O2 => formaldehyde + H(+) + H2O2 + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19553", "l": "H2O + L-tryptophan = indole + NH4(+) + pyruvate"}, {"i": "EC:4.1.99.1", "l": "\"Tryptophanase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33268", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + 2 H2O + meso-2,6-diaminoheptanedioate + NADP(+) => 2 (S)-2-amino-6-oxoheptanedioate + NADPH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29265", "l": "L-leucine(out) + Na(+)(out) => L-leucine(in) + Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28668", "l": "H(+) + hydroxyacetone + NADH => (S)-propane-1,2-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0050309", "l": "sugar-terminal-phosphatase activity"}, {"i": "EC:3.1.3.58", "l": "\"Sugar-terminal-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5251942", "l": "Hikeshi binds HSP70s:ATP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14643", "l": "biuret + CO2 => cyanurate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62627", "l": "[glutaredoxin]-dithiol + a hydroperoxide <=> [glutaredoxin]-disulfide + an alcohol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24747", "l": "L-methionine => 2-aminobut-2-enoate + methanethiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52185", "l": "(E)-(indol-3-yl)acetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] => 1-aci-nitro-2-(1H-indol-3-yl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32145", "l": "L-arginine(out) => L-arginine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.n2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59877", "l": "(indol-3-yl)butanoate + ATP + L-cysteine => (indol-3-yl)butanoyl-L-cysteine + AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34635", "l": "1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 = H2O + NADP(+) + pentalenolactone D"}, {"i": "EC:1.14.13.170", "l": "\"Pentalenolactone D synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420206", "l": "Phosphorylation of SRC-1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9647978", "l": "pro-RAS proteins are farnesylated (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2467775", "l": "Autocleavage of ESPL1 (Separase) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24103", "l": "diisopropyl fluorophosphate + H2O <=> diisopropyl phosphate + fluoride + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956568", "l": "RUNX1 binds the core TAL1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171106", "l": "LDLR:LDL complex => LDLR + LDL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850961", "l": "PREX2 binds PTEN and inhibits it (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68595", "l": "ORC2 binds ORC3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29321", "l": "ethanolamine + H(+) + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57102", "l": "S-methyl-1-thio-D-xylulose 5-phosphate => S-methyl-5-thio-D-ribulose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.99", "l": "\"Spermosin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51242", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26185", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H2O => 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23118", "l": "4-hydroxybenzoyl-CoA + AMP + diphosphate => 4-hydroxybenzoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209973", "l": "Tyrosine is diiodinated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9646685", "l": "Aggresome dissociates from dynein and microtubule (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373748", "l": "SEMA4D interacts with CD72 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9725206", "l": "IgE binds FCERI (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102580", "l": "cyanidin 3-O-glucoside 2-O''-xylosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977071", "l": "Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854736", "l": "FLT3LG dimer:FLT3 binds FLT3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-571318", "l": "Autoubiquitination of oligoTRAF6 bound to p-IRAK2  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14839", "l": "H(+) + H2O2 + oxalate => glyoxylate + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-688137", "l": "RIP2 is K63 polyubiquitinated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56916", "l": "3beta-hydroxy-5alpha-androstan-17-one + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60422", "l": "[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]3 + H(+) => H2O + triglucosyl-enterobactin"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015245", "l": "fatty acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.15", "l": "\"Aminopeptidase Y\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33290", "l": "A + spermidine <=> 1-pyrroline + AH2 + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11287", "l": "hydroxymalonate + NAD(+) <=> H(+) + NADH + oxomalonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66722", "l": "ADP + H(+) + N-[(S)-lactoyl]-L-phenylalanine(out) + phosphate => ATP + H2O + N-[(S)-lactoyl]-L-phenylalanine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52317", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3266566", "l": "G6PC2 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (islet) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47841", "l": "[5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine => (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168885", "l": "Haptoglobin binds Hemoglobin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909738", "l": "SHP1 and SHP2 bind the common beta chain (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55256", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39904", "l": "isoxazolin-5-one + O-acetyl-L-serine => 3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66024", "l": "hypobromite + L-lysyl-[collagen] + L-methionyl-[collagen] = [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66837", "l": "4 O2 + preasperterpenoid A + 4 reduced [NADPH--hemoprotein reductase] => asperterpenoid A + 5 H(+) + 5 H2O + 4 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42473", "l": "dibenzo-p-dioxin + NADH + O2 => 2,2',3-trihydroxydiphenyl ether + H(+) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953398", "l": "PIR oxygenates quercetin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22891", "l": "(R)-methylmalonyl-CoA <=> succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625749", "l": "FOXO1,FOXO3 and SMAD3 bind TRIM63 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.60"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29966", "l": "H(+)(in) + inosine(in) <=> H(+)(out) + inosine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944266", "l": "Association of procollagen type XI (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59552", "l": "N,N',N'',N'''-tetraacetylchitotetraose + O2 = H2O2 + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004948", "l": "calcitonin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33407", "l": "ATP + glycine + H(+) = diphosphate + glycyl-5'-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448702", "l": "Caspase-1 active tetramer formation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36650", "l": "2-hydroxyhexadecanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxyhexadecanoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382096", "l": "Formation of NR-NCOR Corepressor Complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8963915", "l": "1,25(OH)2D binds VDR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53350", "l": "H(+) + NADH + uridine(20a) in tRNA => 5,6-dihydrouridine(20a) in tRNA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-181450", "l": "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52453", "l": "16alpha-hydroxyestrone + UDP-alpha-D-glucuronate => 16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022175", "l": "MECP2:CREB1 complex binds SLC2A3 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163820", "l": "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23970", "l": "(E)-ferulate + 2 H(+) + NADH => (E)-coniferaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8960973", "l": "RLBP1:11cRAL dissociates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936583", "l": "APS is phosphorylated to PAPS (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56705", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 => 3-[(E)-2-isocyanovinyl]indole + 2 CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13690", "l": "diphosphate + glycerol => glycerol 1-phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0016279", "l": "protein-lysine N-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.43"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3790137", "l": "Stimulation of IL8 transcription in senescent cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607004", "l": "Soluble PROCR binds PRTN3:CD177 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9633044", "l": "ESR binds STRN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18124", "l": "an S-substituted L-cysteine + H2O <=> a thiol + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73718", "l": "UBF-1 Binds rDNA Promoter (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000263", "l": "TCII:Cbl is degraded to release Cbl (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34975", "l": "(R)-pantothenate(in) = (R)-pantothenate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399982", "l": "AKT1 E17K mutant phosphorylates TSC2, inhibiting it (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8866851", "l": "CFTR transits to the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58026", "l": "H(+) + oleanolate 3-O-beta-D-glucoside + UDP => oleanolate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30949", "l": "10-epi-gamma-eudesmol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14052", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4,11-diene <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047191", "l": "1-alkylglycerophosphocholine O-acyltransferase activity"}, {"i": "MetaCyc:2.3.1.63-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0016427", "l": "tRNA (cytosine) methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382055", "l": "Grb7 binds to the active PDGF receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656258", "l": "Defective ST3GAL3 does not transfer SA to keratan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30682", "l": "D-cellobiose + H2O <=> 2 beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35776", "l": "L-glutamine + UDP-3-oxo-alpha-D-glucose => 2-oxoglutaramate + UDP-alpha-D-kanosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432956", "l": "BP230 is recruited to the hemidesmosome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9681294", "l": "IL6R binds IL6R inhibitors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57878", "l": "pseudouridine(54) in tRNA => uridine(54) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0089714", "l": "UDP-N-acetyl-D-mannosamine dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5618331", "l": "HDAC6 deacetylates microtubules (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51516", "l": "(R)-reticuline + S-adenosyl-L-methionine = (R)-tembetarine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195275", "l": "Phosphorylation of APC component of the destruction complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373074", "l": "Receptor CCR9  binds CCL25 ligand (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61861", "l": "dehydroprobetaenone I + H(+) + NADPH + O2 => epoxybetaenone + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428231", "l": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66843", "l": "asperterpenoid A + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> asperterpenoid B + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43573", "l": "A + D-arginine + H2O => 5-guanidino-2-oxopentanoate + AH2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29733", "l": "beta-maltose(out) => beta-maltose(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783473", "l": "LCMT2 methoxycarbonylates OHyW-72 yielding OHyW (hydroxywybutosine) at nucleotide 37 of tRNA(Phe) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41708", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphoethanolamine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9690493", "l": "RHOB binds effectors on endosomes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5689861", "l": "Recruitment of XPA and release of CAK  (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015094", "l": "lead ion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110440", "l": "Autophosphorylation of DINR (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2995330", "l": "COX10 transforms heme to heme O (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.12"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52078", "l": "(9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H(+) => 13-(9Z-hexadecenoyloxy)-octadecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57341", "l": "3-hydroxy-L-kynurenine + S-adenosyl-L-methionine => 3-hydroxy-4-methyl-L-kynurenine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50839", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 <=> 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36655", "l": "desmethyldescarbamoylnovobiocin + S-adenosyl-L-methionine = descarbamoylnovobiocin + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.285", "l": "\"Demethyldecarbamoylnovobiocin O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419843", "l": "CALCA(83-119) binds CALCR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390011", "l": "HPO dimer binds to SAV (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22347", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + (E)-caffeoyl-CoA <=> (R)-rosmarinate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161732", "l": "TXB2 is converted to 11dh-TXB2 by TXDH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047316", "l": "glutamine-phenylpyruvate transaminase activity"}, {"i": "RHEA:17593", "l": "3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine"}, {"i": "EC:2.6.1.64", "l": "\"Glutamine--phenylpyruvate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39814", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33959", "l": "2-oxoglutarate + neomycin C = 6'''-deamino-6'''-oxoneomycin C + L-glutamate"}, {"i": "EC:2.6.1.95", "l": "\"Neomycin C transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27731", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli) => beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53157", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(5,6-epoxy-8Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.30"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10398", "l": "a 2-oxocarboxylate + H(+) + NADH + NH4(+) => an L-alpha-amino acid + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-688985", "l": "K63 polyubiquitinated RIP2 associates with the TAK1 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419166", "l": "GEFs activate RhoA,B,C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11835", "l": "(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) <=> H(+) + NADH + naphthalene-1,2-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018808", "l": "RAC3 binds effectors at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62996", "l": "(8Z,11Z,14Z)-eicosatrienamide + H2O = (8Z,11Z,14Z)-eicosatrienoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61511", "l": "peonidin + UDP-alpha-D-glucose <=> peonidin 3-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9664879", "l": "ATM:PEX5 binds ATM (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41552", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = diphosphate + ophiobolin F"}, {"i": "EC:4.2.3.145", "l": "\"Ophiobolin F synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250979", "l": "botG:SYT1:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24269", "l": "2,6-dioxo-6-phenylhexanoate + NADP(+) => 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689111", "l": "PARK2 autoubiquitinates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950778", "l": "p-Y693-STAT4 dimerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58477", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61891", "l": "diosgenin + UDP-alpha-D-glucose <=> diosgenin 3-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47431", "l": "(3S)-hydroxy-(9Z-octadecenoyl)-CoA + NAD(+) <=> 3-oxo-(9Z-octadecenoyl)-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672011", "l": "p-AMPK:AMP binds the ULK complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62518", "l": "H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65875", "l": "1,17beta-dihydroxyandrostan-3-one + A <=> 17beta-hydroxyandrostan-1,3-dione + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654163", "l": "Activated FGFR4 binds PLCG1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61649", "l": "ATP + holo-[non-ribosomal peptide synthase] + salicylate => AMP + diphosphate + salicyl-[non-ribosomal peptide synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22841", "l": "D-glutamine + H2O => D-glutamate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65297", "l": "(2R)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44663", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + sphing-4-enine <=> 1-O-alkyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905172", "l": "RISC complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20950", "l": "CO2 + sulfoacetaldehyde => 3-sulfopyruvate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14816", "l": "L-2-aminohexano-6-lactam <=> D-2-aminohexano-6-lactam"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52327", "l": "2 L-arginine + 4 O2 + 3 reduced [flavodoxin] <=> 5 H(+) + 4 H2O + 2 L-citrulline + 2 nitric oxide + 3 oxidized [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627107", "l": "XIAP binds CASP7 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37233", "l": "L-alanine + NH4(+) => H2O + L-alaninamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193981", "l": "CYP21A2 oxidises 17HPROG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47249", "l": "2 [Fe(III)cytochrome c] + L-gulono-1,4-lactone => 2 [Fe(II)cytochrome c] + 3 H(+) + L-ascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58093", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156678", "l": "Activation of Cdc25C (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6790454", "l": "SUMOylation of XPC (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981637", "l": "Complement factor I inactivates C4BP-bound C4b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45732", "l": "D-ribulose 5-phosphate + L-tyrosine = (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate"}, {"i": "EC:4.1.99.24", "l": "\"L-tyrosine isonitrile synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39326", "l": "(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50365", "l": "(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-nandinine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427394", "l": "Cleavage of intergenic spacer RNA to yield fragments of 150-300 nucleotides (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050399", "l": "xanthommatin reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12598", "l": "acetyl-CoA + phosphinothricin => CoA + H(+) + N-acetylphosphinothricin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984609", "l": "Kinesin-8 is a dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042016", "l": "interleukin-20 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12161", "l": "2-deoxy-D-gluconate + NAD(+) => 3-dehydro-2-deoxy-D-gluconate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50591", "l": "13,14-dihydro-15-oxo-PGF2alpha + NADP(+) <=> 15-oxoprostaglandin F2alpha + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36750", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose <=> beta-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9035484", "l": "CysS248-MPST:TXN2 dissociates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37594", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52792", "l": "chlorophyllide a + 2 H(+) = Mg(2+) + pheophorbide a"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.37"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5617179", "l": "PRKACA phosphorylates TNNI3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5444523", "l": "Formation of MSH1:PMS2 Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-517674", "l": "p-S158,221-HuR binds mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371422", "l": "ATP hydrolysis by HSP70 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49326", "l": "all-trans-capsorubin => (5R,6S)-5,6-epoxi-capsanthin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66078", "l": "H2O + kynurenate + L-2-aminopentanoate => 2-oxopentanoate + L-kynurenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158118", "l": "factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-167429", "l": "The receptor:G-protein complex  binds GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-378952", "l": "Thyrotropin is a heterodimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170979", "l": "(Frs2)C3G stimulates nucleotide exchange on Rap1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59725", "l": "D-maltoheptaono-1,5-lactone + H2O => D-maltoheptaonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-744231", "l": "SLC35D2 exchanges UDP-sugars for UMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19834", "l": "(6S)-10-formyltetrahydrofolate + H2O => (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34973", "l": "Fe(3+)(out) => Fe(3+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58926", "l": "(-)-maackiain + H2O => (3R,4R)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-4,7-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43717", "l": "[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate => [glutamine synthetase]-L-tyrosine + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395992", "l": "p-T,4S-IRF3 is dimerized (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961972", "l": "E2F1 binds the RRM2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46057", "l": "(11E)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (11E,13Z)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55521", "l": "dimethylallyl diphosphate + 3 isopentenyl diphosphate => 3 diphosphate + nerylneryl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40708", "l": "(9Z,12Z,15Z)-octadecatrien-1-ol + 1-hexadecanoylglycerone 3-phosphate => 1-O-(9Z,12Z,15Z)-octadecatrienylglycerone 3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736992", "l": "p-2S-SMAD2,3:SMAD4 binds JUNB gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001863", "l": "collectin receptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050418", "l": "hydroxylamine reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19812", "l": "(S)-ureidoglycolate + 2 H(+) + H2O <=> CO2 + glyoxylate + 2 NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034801", "l": "2,4-dinitrocyclohexanone hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10716", "l": "D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate"}, {"i": "EC:5.5.1.4", "l": "\"Inositol-3-phosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50539", "l": "prostaglandin E2 <=> H2O + prostaglandin A2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799350", "l": "Exocytosis of specific granule membrane proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49310", "l": "a neolactoside nLc4Cer(d18:0) + L-fucose => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53984", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55751", "l": "coenzyme B + coenzyme M + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983696", "l": "The Immunoglobulin of the BCR binds antigen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41463", "l": "1,2-diacyl-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> a 1,2-diacylglycerol + a sphingomyelin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64341", "l": "(2E,6E)-farnesyl diphosphate + 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one => 4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452097", "l": "Recruited STAT5 is phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35060", "l": "chloramphenicol(in) + H(+)(out) => chloramphenicol(out) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047204", "l": "chlorogenate-glucarate O-hydroxycinnamoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10173", "l": "(3R)-hydroxybutanoate dimer + H2O => 2 (R)-3-hydroxybutanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047768", "l": "carboxy-cis,cis-muconate cyclase activity"}, {"i": "RHEA:14977", "l": "3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate"}, {"i": "EC:5.5.1.5", "l": "\"Carboxy-cis,cis-muconate cyclase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50896", "l": "8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O = (8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098848", "l": "alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28105", "l": "GDP-alpha-D-mannose + H2O <=> D-mannose + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009558", "l": "IL34 dimer binds SDC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65268", "l": "3-hydroxypentacecilide A + H(+) + NADPH + O2 = chrodrimanin F + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52090", "l": "5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate => 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45755", "l": "(3E)-decenoyl-CoA <=> (2E)-decenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49478", "l": "H(+) + L-2-aminoadipate + NADH => 2 H2O + L-1-piperideine-6-carboxylate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15774", "l": "ATP + dihydroxyacetone => ADP + dihydroxyacetone phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0016900", "l": "oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor"}, {"i": "EC:1.1.4.-", "l": "\"With a disulfide as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59507", "l": "cholesterol + glycyl-L-cysteinyl-[protein] + H(+) <=> [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.44", "l": "\"Nuclear-inclusion-a endopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209118", "l": "Membrane localised SGG phosphorylates ARR (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57707", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+) <=> 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54601", "l": "2-oxoglutarate + O2 + octanoyl-CoA => 2-hydroxyoctanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50612", "l": "decanal + NADP(+) = (2E)-decenal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.7.9", "l": "\"Isotuberculosinol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48346", "l": "a D-galactosylceramide + H(+) + UDP => an N-acyl-sphingoid base + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166015", "l": "Association of LBP with LPS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956659", "l": "ABL1 phosphorylates YAP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53901", "l": "ATP + L-threonyl-[myosin light chain] => ADP + H(+) + O-phospho-L-threonyl-[myosin light chain]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625416", "l": "Anterograde IFT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45624", "l": "ATP + holo-[CmaA peptidyl-carrier protein] + L-alloisoleucine = AMP + diphosphate + L-alloisoleucyl-[CmaA peptidyl-carrier protein]"}, {"i": "EC:6.2.1.46", "l": "\"L-allo-isoleucine--holo-[CmaA peptidyl-carrier protein] ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62782", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O => 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43086", "l": "2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(34) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39751", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003887", "l": "DNA-directed DNA polymerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863914", "l": "Transport of SEC22B, TAP and PLC from ER to ERGIC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23691", "l": "adenine + H(+) + H2O <=> hypoxanthine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12948", "l": "2'-hydroxybiphenyl-2-sulfinate + H2O <=> biphenyl-2-ol + H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-114284", "l": "Release of Cytochrome c from mitochondria (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730886", "l": "Phosphorylation of SHC by SYK kinase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25074", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O"}, {"i": "EC:4.2.1.92", "l": "\"Hydroperoxide dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15183", "l": "ADP + an acyl-CoA(in) + H(+) + phosphate => an acyl-CoA(out) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17273", "l": "(4-hydroxyphenyl)acetaldehyde + H2O + NAD(+) = 4-hydroxyphenylacetate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.53", "l": "\"4-hydroxyphenylacetaldehyde dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20339", "l": "(R)-lactate + H(+) + sulfate => (R)-2-O-sulfolactate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37207", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9674531", "l": "AAMP binds EGFR (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350058", "l": "Formation of CSL NCOR corepressor complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9007539", "l": "CHEK1 phosphorylates E2F6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50601", "l": "acetyl-CoA + N-terminal L-seryl-[histone H2A] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018463", "l": "6-hydroxyhexanoate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12676", "l": "an aliphatic amide <=> a nitrile + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.51"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237129", "l": "Acireductone is created (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052732", "l": "phosphoethanolamine phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622840", "l": "HSPA8 dissociates from LAMP2A-bound substrate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24515", "l": "L-serine + pyrazole <=> 3-(pyrazol-1-yl)-L-alanine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47533", "l": "chenodeoxycholate + NAD(+) => 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797100", "l": "CCNK binds CDK13 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47434", "l": "(2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (7Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661517", "l": "LUBAC comlex binds OTULIN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32763", "l": "(3R)-3-methyl-D-ornithine + L-lysine = (3R)-3-methyl-D-ornithyl-N(6)-L-lysine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807106", "l": "PTEN undergoes monoubiquitination (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10565", "l": "H2O + oxaloacetate 4-methyl ester => H(+) + methanol + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74740", "l": "Binding of SHC1 to insulin receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20358", "l": "3-phenylpropanoate + H(+) + NADH + O2 => 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.239", "l": "\"Carnitine monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632039", "l": "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51441", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (11S)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2484882", "l": "Collagen type X degradation by MMP3, 13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1461995", "l": "pro-defensin alpha 5 is stored in Paneth cell granules (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44185", "l": "D-sedoheptulose 7-phosphate => 2-epi-5-epi-valiolone + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111962", "l": "PDE4A,C,D hydrolyse cAMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086085", "l": "cell adhesive protein binding involved in SA cardiac muscle cell-atrial cardiac muscle cell communication"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9652264", "l": "ERBB2 binds TKIs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22211", "l": "3-hydroxyphenylacetate + H(+) + NADH + O2 <=> H2O + homogentisate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444202", "l": "Receptor FFAR1 binds free fatty acids (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69152", "l": "Removal of remaining Flap (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32329", "l": "H(+) + NADH + zerumbone => 10-hydroxy-alpha-humulene + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578965", "l": "TNRC6A binds AGO2:miRNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102748", "l": "geranylgeranyl-chlorophyll a reductase activity"}, {"i": "MetaCyc:RXN-7664"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706315", "l": "Active FLT3 binds to SH2B3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54292", "l": "ATP + L-threonyl-[protein] = 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-83788", "l": "Binding of TFIIIC to Type 2 promoter (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36024", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390835", "l": "DRD1,5 bind DA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32003", "l": "(+)-copalyl diphosphate = diphosphate + isopimara-8(14),15-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39480", "l": "(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADPH => (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799466", "l": "TP53I3 dimerizes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56440", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66338", "l": "L-glutamate(in) => L-glutamate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696564", "l": "USP25 deubiquitinates DDX58 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050065", "l": "lysine-pyruvate 6-transaminase activity"}, {"i": "MetaCyc:LYSINE--PYRUVATE-6-AMINOTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18481", "l": "cyclohexylsulfamate + H2O = cyclohexylamine + sulfate"}, {"i": "EC:3.10.1.2", "l": "\"Cyclamate sulfohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168635", "l": "PRKCB (PKC-beta) phosphorylates CARMA1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082356", "l": "HSF1-mediated gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36874", "l": "(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.12", "l": "\"DNA helicase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043115", "l": "precorrin-2 dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65280", "l": "alpha-NeuNAc-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1<->1')-L-Ser-[protein] + CMP-N-acetyl-beta-neuraminate = alpha-NeuNAc-(2->3)-beta-D-Gal-(1->3)-[alpha-NeuNAc-(2->6)]-alpha-D-GalNAc-(1<->1')-L-Ser-[protein] + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0008126", "l": "acetylesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57291", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O <=> a guanosine in RNA + H(+) + lactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63109", "l": "16-hydroxy-ilicicolin A epoxide => ascofuranol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24026", "l": "(2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine => (2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690702", "l": "LYN phosphorylates CD22 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25821", "l": "H2O + O2 + spermidine => 4-aminobutanal + H2O2 + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507868", "l": "Aquaporins passively transport water into cells (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34491", "l": "H2O + UDP-N,N'-diacetylbacillosamine = 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6797100", "l": "CCNK binds CDK13 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18757", "l": "2-oxoglutarate + 7-deoxycylindrospermopsin + O2 = CO2 + cylindrospermopsin + succinate"}, {"i": "RHEA:61612", "l": "2-oxoglutarate + 7-deoxycylindrospermopsin + O2 = 7-epi-cylindrospermopsin + CO2 + succinate"}, {"i": "EC:1.14.11.70", "l": "\"7-deoxycylindrospermopsin hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42966", "l": "pseudouridine(54/55) in tRNA => uridine(54/55) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663273", "l": "RORA, EP300, PPARGC1A bind NR1D1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28997", "l": "H(+)(in) + L-threonine(out) => H(+)(out) + L-threonine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60523", "l": "2 H2O + L-cystine-bis-glycine <=> 2 glycine + L-cystine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373075", "l": "Metabotropic glutamate receptors bind glutamate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47541", "l": "7-oxolithocholate + H(+) + NADPH => NADP(+) + ursodeoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0060589", "l": "nucleoside-triphosphatase regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798257", "l": "PTPRS binds NTRK3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62401", "l": "(1R,2S)-ephedrine + NAD(+) => (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26515", "l": "cyclohexan-1,2-dione + H2O => 6-oxohexanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202222", "l": "Phosphorylation of PKC theta (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955844", "l": "RBKS phosphorylates ribose to R5P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683831", "l": "CCDC59 binds TTF1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034074", "l": "marneral synthase activity"}, {"i": "RHEA:31875", "l": "(S)-2,3-epoxysqualene = marneral"}, {"i": "MetaCyc:RXN-9664"}, {"i": "EC:5.4.99.53", "l": "\"Marneral synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180632", "l": "Deamination of C residues during synthesis of HIV-1 reverse transcript minus-strand (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675194", "l": "Activated MAPK phosphorylates RAF1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8856951", "l": "PP2A demethylation by PPME1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15144", "l": "4-methylphenol + H2O + 4 oxidized [azurin] <=> 4-hydroxybenzaldehyde + 4 H(+) + 4 reduced [azurin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56332", "l": "5'-triphosphoadenylyl-(2'->5')-adenosine + H2O = AMP + ATP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29890", "l": "ATP + H2O + L-lysine(out) <=> ADP + H(+) + L-lysine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2129362", "l": "Fibrillin microfibril assembly (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64924", "l": "dATP + 2 H2O = dAMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50373", "l": "an N-acylsphingoid base 1-phosphate(in) => an N-acylsphingoid base 1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3244643", "l": "STING binds cyclic GMP-AMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70272", "l": "PGM:Mg2+ isomerise G6P to G1P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109702", "l": "PDPK1 phosphorylates AKT2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694462", "l": "ABHD6,12 hydrolyse 3AG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60794", "l": "3 CO2 + gibberellin A17 + H(+) + H2O + 3 succinate => 3 2-oxoglutarate + gibberellin A53 + 3 O2"}]}
{"type": "biolink:MolecularActivity", "ic": "68.973118714897424", "identifiers": [{"i": "GO:0015297", "l": "antiporter activity"}, {"i": "REACT:R-HSA-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13298", "l": "3 H(+) + malonyl-CoA + 2 NADH + octadecanoyl-CoA => CO2 + CoA + eicosanoyl-CoA + H2O + 2 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042015", "l": "interleukin-20 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008822", "l": "PPM1D dephosphorylates RUNX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551683", "l": "SUMOylation of TOPORS with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871366", "l": "p-Y281,292-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64919", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O <=> a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11754", "l": "acetate + H(+) + salicylate => acetylsalicylate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37676", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33864", "l": "menaquinone-7 + succinate => fumarate + menaquinol-7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24293", "l": "acetyl-CoA + L-glutamate => CoA + H(+) + N-acetyl-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57547", "l": "(S)-beta-macrocarpene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + zealexin A1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17880", "l": "a catechol + S-adenosyl-L-methionine <=> a guaiacol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19658", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NADP(+) => CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804383", "l": "PRMT5 methylates TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34265", "l": "diphosphate + fumigaclavine C => dimethylallyl diphosphate + fumigaclavine A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55662", "l": "2 A + echinenone + 3 H2O => 2 AH2 + all-trans-beta-carotene + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15471", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide => 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61538", "l": "ent-kaur-16-en-19-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-ene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610726", "l": "The IFT-A complex recruits TULP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44761", "l": "2-methoxy-6-all-trans-nonaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811412", "l": "Active ARF recruits coatomer to the Golgi (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48934", "l": "CMP + ganglioside GQ1b + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GT1b"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60637", "l": "N-(dodecanoyl)-sphing-4-enine-1-phosphocholine => choline + N-dodecanoyl-sphing-4-enine-1,3-cyclic phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109860", "l": "MAP2K1 phosphorylates MAPK3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450975", "l": "isocitrate <=> citrate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47528", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH = isocholate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65180", "l": "AH2 + O2 + protoaustinoid B = A + H2O + preaustinoid A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49560", "l": "D-sedoheptulose 7-phosphate = (R)-demethyl-4-deoxygadusol + H(+) + H2O + phosphate"}, {"i": "EC:4.2.3.154", "l": "\"Demethyl-4-deoxygadusol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163310", "l": "TFAM binds to mitochondrial promoters (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45865", "l": "16-hydroxyhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.16"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12816", "l": "L-glutamate <=> D-glutamate"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004856", "l": "xylulokinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39648", "l": "AH2 + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + S-adenosyl-L-methionine => 5'-deoxyadenosine + A + dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + H(+) + L-methionine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15225", "l": "alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose"}, {"i": "EC:2.7.7.24", "l": "\"Glucose-1-phosphate thymidylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27709", "l": "ATP + D-alanine + D-serine <=> ADP + D-alanyl-D-serine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3858489", "l": "ppDVL binds DAAM1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102510", "l": "pelargonidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41056", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + dodecanoyl-CoA => 1,2-di-(9Z)-octadecenoyl-3-dodecanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202216", "l": "Phosphorylation of SLP-76 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38773", "l": "1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3828061", "l": "Defective GYS1 does not transfer glucose to growing glycogen chains (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399939", "l": "Autophosphorylation of PAK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392295", "l": "Gbeta:gamma recruits PI3K gamma (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43854", "l": "3-oxo-dotriacontanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + triacontanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65905", "l": "3-hydroxy-L-kynurenine + glyoxylate => 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102324", "l": "2-hydroxy-6-oxo-nona-2,4-dienoate hydrolase activity"}, {"i": "MetaCyc:RXN-13157"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2230983", "l": "LRP1:Hemopexin:heme is endocytosed (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433418", "l": "Phosphorylation of JAK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31975", "l": "H(+) + NADPH + O2 + taxusin = 7beta-hydroxytaxusin + H2O + NADP(+)"}, {"i": "EC:1.14.13.147", "l": "\"Taxoid 7-beta-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43183", "l": "cytidine(2278) in 25S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(2278) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0097001", "l": "ceramide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55255", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine <=> 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013108", "l": "GDIs block activation of RHOC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15446", "l": "H(+) + H2O + O-carbamoyl-L-serine => CO2 + 2 NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507873", "l": "Aquaporins passively transport urea out of cells (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993781", "l": "Conjugation of SUMO3 to UBA2:SAE1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12874", "l": "(R)-2-hydroxy-4-methylpentanoate + NADP(+) => 4-methyl-2-oxopentanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18812", "l": "L-alanine + oxomalonate <=> aminomalonate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42823", "l": "2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2 <=> H2O + 2 NADP(+) + tetracenomycin C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110322", "l": "Formation of Pol zeta complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45210", "l": "[Co(I) methanol-specific corrinoid protein] + H(+) + methyl-coenzyme M => [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30036", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADH + O2 => benzene-1,2,4-triol + CO2 + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420977", "l": "Ca permeable AMPA receptor ligand binding (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32412", "l": "(1R,2R,4S)-isodihydrocarveol + NAD(+) => (1R,4S)-isodihydrocarvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15379", "l": "(2S)-2-hydroxy-3,4-dioxopentyl phosphate + ADP + H(+) => (S)-4,5-dihydroxypentane-2,3-dione + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211191", "l": "Association of DFF with alpha:beta importin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983870", "l": "JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12261", "l": "ATP + NADH => ADP + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873918", "l": "Transphosphorylation of JAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159771", "l": "Furin cleaves pro-protein C to protein C (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13812", "l": "aspulvinone E + 2 dimethylallyl diphosphate <=> aspulvinone H + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102708", "l": "S-adenosyl-L-methionine:N-methyl-beta-alanine N-methyltransferase activity"}, {"i": "MetaCyc:RXN-6462"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31110", "l": "3-phenylpyruvate + O2 <=> (2-hydroxyphenyl)acetate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202714", "l": "CD58 binds CD2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161619", "l": "PGI2 is hydrolysed to 6k-PGF1a (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11042", "l": "3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O => D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20101", "l": "a long-chain fatty acid + ATP + L-cysteinyl-[protein] = AMP + diphosphate + S-(long-chain fatty acyl)-L-cysteinyl-[protein]"}, {"i": "EC:6.2.1.19", "l": "\"Long-chain-fatty-acid--protein ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33248", "l": "O2 + putrescine => 1-pyrroline + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10345", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983194", "l": "Kinesin-1 is a heterotetramer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793947", "l": "Defective MOGS does not cleave glucose from an N-glycosylated protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39959", "l": "1-hexadecanoylglycerol + H2O = glycerol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12456", "l": "CTP + D-ribitol 5-phosphate + H(+) = CDP-L-ribitol + diphosphate"}, {"i": "EC:2.7.7.40", "l": "\"D-ribitol-5-phosphate cytidylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051737", "l": "GTP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58803", "l": "3',3'-cGAMP + H2O <=> 5'-pApG-3' + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209188", "l": "TAK1-binding protein TAB2 binds to TAK1 kinase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334152", "l": "DNMT3A:DNMT3L methylates cytosine in DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53300", "l": "D-5-[2-(methylsulfanyl)ethyl]hydantoin + H2O = H(+) + N-carbamoyl-D-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49397", "l": "20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909729", "l": "Activation of JAK kinases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-708349", "l": "Activated NOD2 oligomerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35621", "l": "D-glucarate => L-idarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35303", "l": "3-hydroxyisopentadecanoyl-CoA + NADP(+) = 3-oxoisopentadecanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62734", "l": "(+)-isomalbrancheamide D + FADH2 => (+)-isomalbrancheamide B + bromide + FAD + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201669", "l": "Beta-catenin translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.14", "l": "\"Procollagen N-endopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928639", "l": "p-EFNB binds GRB4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29695", "l": "cob(I)inamide(in) = cob(I)inamide(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694522", "l": "Inner coat assembly and cargo binding (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202111", "l": "AKT1 phosphorylates eNOS (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60198", "l": "CO2 + formaldehyde + L-lysyl(9)-[histone H3] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl(9)-[histone H3] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35620", "l": "L-idarate => D-glucarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66676", "l": "(2E,6E)-farnesyl diphosphate + 5,7-dihydroxy-4-methylphthalide = 4-farnesyl-3,5-dihydroxy-6-methylphthalide + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.53", "l": "\"Trimerelysin II\""}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0015172", "l": "acidic amino acid transmembrane transporter activity"}, {"i": "REACT:R-HSA-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612509", "l": "SGK phosphorylates SRF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22883", "l": "2-oxoglutarate + L-arogenate <=> L-glutamate + prephenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39349", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+) => (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5683593", "l": "ATG7:ATG3:LC3 dissociates (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700168", "l": "Active ALK phosphorylates IRS1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685607", "l": "Sialic acid binds SIGLEC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "75.076548671259488", "identifiers": [{"i": "GO:0000166", "l": "nucleotide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32252", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+) => (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730835", "l": "Autophosphorylation of PKC-theta (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5606996", "l": "Soluble PROCR binds activated protein C (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021609", "l": "ESR-associated SRC autophosphorylates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853325", "l": "Plasma membrane FGFR1 fusions autophosphorylate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632679", "l": "EVC2:EVC binds p-SMO (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396399", "l": "Fibrillins bind BMPs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52273", "l": "(1H-indol-3-yl)-N-methylmethanamine + S-adenosyl-L-methionine => gramine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717382", "l": "SCN9A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35317", "l": "3-oxooctadecanoyl-CoA + CO2 + CoA => H(+) + hexadecanoyl-CoA + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061860", "l": "DNA clamp unloader activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10134", "l": "AMP + benzoyl-CoA + diphosphate => ATP + benzoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60110", "l": "(E)-4-coumaroyl-CoA + H2O => (R)-3-(4-hydroxyphenyl)lactoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43502", "l": "D-glucaro-1,5-lactone + H(+) + NADH => beta-D-glucuronate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40941", "l": "1-O-hexadecyl-sn-glycero-3-phosphate + NADP(+) => 1-O-hexadecylglycerone 3-phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174446", "l": "Removal of remaining Flap from the C-strand (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10322", "l": "1-pyrroline-2-carboxylate + H2O => trans-3-hydroxy-L-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42099", "l": "ATP + carbamoyl phosphate + H2O + tobramycin <=> AMP + diphosphate + H(+) + nebramycin 5' + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9603784", "l": "PEX19:class I PMP binds PEX3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21056", "l": "lactoyl-CoA = acryloyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389350", "l": "Activation of Cdc42 by pVav1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51660", "l": "an N-(1,2-saturated acyl)sphinganine + H(+) + NADPH + O2 = an N-(2-hydroxyacyl)-sphinganine + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24502", "l": "ATP + H(+) + phosphate => adenosine 5'-tetraphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48398", "l": "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H(+) + S-adenosyl-L-homocysteine => (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005358", "l": "high-affinity glucose:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948775", "l": "MKRN1 polyubiquitinates PTEN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27896", "l": "cytidine + phosphate => 3'-CMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35357", "l": "(2E)-13-methyltetradecenoyl-CoA + H2O => 3-hydroxyisopentadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9725206", "l": "IgE binds FCERI (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38476", "l": "L-histidine + S-adenosyl-L-methionine => H(+) + N(alpha)-methyl-L-histidine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.114", "l": "\"Polyprenyldihydroxybenzoate methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1458433", "l": "Collagen type I degradation by MMP14 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50666", "l": "an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "ic": "71.333297062267803", "identifiers": [{"i": "GO:0015370", "l": "solute:sodium symporter activity"}, {"i": "REACT:R-HSA-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9658253", "l": "RAS:GTP binds PI3K (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29658", "l": "L-cysteine(in) <=> L-cysteine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57350", "l": "3-hydroxy-4-methylanthranilate + H(+) + L-alanine => 3-hydroxy-4-methyl-L-kynurenine + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047530", "l": "2,4-diaminopentanoate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66506", "l": "1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 2 [Fe(III)-cytochrome b5] + 2 H2O => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19644", "l": "(E)-4-coumarate + ATP + CoA <=> (E)-4-coumaroyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2484822", "l": "Kinetochore assembly (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211960", "l": "CYP2U1 19-hydroxylates ARA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62168", "l": "H2O + N,N'-diacetylchitobiose = acetate + beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine"}, {"i": "EC:3.5.1.136", "l": "\"N,N'-diacetylchitobiose non-reducing end deacetylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11620", "l": "H2O + L-2-amino-4-chloropent-4-enoate = 2-oxopent-4-enoate + chloride + H(+) + NH4(+)"}, {"i": "EC:4.5.1.4", "l": "\"L-2-amino-4-chloropent-4-enoate dehydrochlorinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16260", "l": "alpha,alpha-trehalose + phosphate <=> alpha-D-glucose + alpha-D-glucose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66143", "l": "acetyl-CoA + octopamine <=> CoA + H(+) + N-acetyloctopamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031880", "l": "type 3 somatostatin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4518575", "l": "miR-92b binds 3'UTR of NLK mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612219", "l": "ERBB4s80 binds to SRC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "72.105362717182985", "identifiers": [{"i": "GO:0016814", "l": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"}, {"i": "EC:3.5.4.-", "l": "\"In cyclic amidines\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198440", "l": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53152", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-917700", "l": "MVB Vesicle Formation (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18833", "l": "4-formylbenzenesulfonate + H2O + NAD(+) = 4-sulfobenzoate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.62", "l": "\"4-formylbenzenesulfonate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870465", "l": "RGGT binds the RAB-binding subunit (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40622", "l": "H2O + tridodecanoylglycerol <=> 2,3-didodecanoyl-sn-glycerol + dodecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20583", "l": "2 H(+) + hydroxylamine + NADH => H2O + NAD(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52463", "l": "17beta-estradiol + UDP-alpha-D-glucuronate <=> 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42911", "l": "S-adenosyl-L-methionine + uridine(1939) in 23S rRNA <=> 5-methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50004", "l": "H(+) + NADPH + O2 + tetracycline = 11a-hydroxytetracycline + H2O + NADP(+)"}, {"i": "EC:1.14.13.231", "l": "\"Tetracycline 11a-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54848", "l": "H(+) + hexan-3-one + NADPH + O2 = H2O + NADP(+) + propyl propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30767", "l": "D-glucurono-3,6-lactone + H2O = D-glucuronate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54836", "l": "H(+) + heptan-2-one + NADPH + O2 = H2O + NADP(+) + pentyl acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47009", "l": "[DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide => [DsrC protein]-dithiol + 2 AH2 + H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873919", "l": "Phosphorylation of JAK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68615", "l": "Formation of ORC(1-6) complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65035", "l": "3 a quinone + protoporphyrinogen IX <=> 3 a quinol + protoporphyrin IX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381608", "l": "cAMP activates EPAC2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36404", "l": "a cholesterol ester + H2O => a fatty acid + cholesterol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30289", "l": "9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol => 15-cis-phytoene + 2 a plastoquinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28011", "l": "propanoyl-CoA + succinate => propanoate + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001733", "l": "galactosylceramide sulfotransferase activity"}, {"i": "RHEA:43304", "l": "3'-phosphoadenylyl sulfate + beta-D-Gal-(1<->1')-Cer = 1-(3-O-sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44333", "l": "ATP + L-alanine + L-anticapsin => ADP + bacilysin + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14163", "l": "3-(methylsulfanyl)propanoate + CO + formate + 2 H(+) => 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54015", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944230", "l": "Association of procollagen type XVIII (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15061", "l": "2 a Fe(II)-siderophore + H(+) + NAD(+) = 2 a Fe(III)-siderophore + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27455", "l": "3-iodo-L-tyrosine + NADPH => iodide + L-tyrosine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417908", "l": "P2RY1 binds ADP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59403", "l": "L-2-aminohexanoate <=> D-2-aminohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24285", "l": "L-aspartate 4-semialdehyde + NADP(+) + phosphate => 4-phospho-L-aspartate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788623", "l": "p-Y-STATs translocate to nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25073", "l": "3-hydroxybenzoate + ATP + CoA <=> 3-hydroxybenzoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10214", "l": "5-oxopentanoate + L-glutamate => 2-oxoglutarate + 5-aminopentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61589", "l": "amicoumacin A + ATP => ADP + amicoumacin A 2-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32810", "l": "thiosulfate(in) <=> thiosulfate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9699578", "l": "Active FLT3 phosphorylates CDKN1B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0019975", "l": "interleukin-17 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373741", "l": "SDK2 homophillic interaction (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617829", "l": "Assembly of IFT A complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60720", "l": "(E)-hept-2-enal + H2O + NADP(+) = (E)-hept-2-enoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800490", "l": "ATM phosphorylates PIDD1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24766", "l": "UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate => UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39783", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58863", "l": "4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.156", "l": "\"Phloroisovalerophenone synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20184", "l": "alpha-D-mannose derivative + UDP-alpha-D-glucose <=> 6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61346", "l": "3-hydroxypyruvate + H2O2 + NH4(+) => H2O + L-serine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36919", "l": "(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.35", "l": "\"Tissue kallikrein\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66475", "l": "(2Z,6E,10E,14E)-geranylfarnesol <=> 18-episcalar-17(25)-en-19-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420206", "l": "Phosphorylation of SRC-1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62324", "l": "(+)-malbrancheamide B + chloride + FAD + 2 H(+) = (+)-malbrancheamide + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913675", "l": "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-179417", "l": "Multiubiquitination of Nek2A (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32225", "l": "AMP + H(+) + NADH + phosphate => (6S)-NADHX + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57175", "l": "(S)-2-hydroxyglutarate + NAD(+) <=> 2-oxoglutarate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "55.430435234126001", "identifiers": [{"i": "GO:0016741", "l": "transferase activity, transferring one-carbon groups"}, {"i": "EC:2.1.-.-", "l": "\"Transferring one-carbon groups\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33575", "l": "an inositol-1-phosphophytoceramide + beta-D-mannose = a mannosylinositol-1-phosphophytoceramide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400143", "l": "Fatty acid ligands activate PPARA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198958", "l": "KIR2DL2/3 interacting with HLA-C group 1 (Cw4) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938930", "l": "RUNX1 binds ELF2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9733973", "l": "Bile salts bind FABP6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35547", "l": "cyclo(L-tyrosyl-L-tyrosyl) + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.19.70", "l": "\"Mycocyclosin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36826", "l": "1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol <=> CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66239", "l": "IC-asc-C9-CoA + O2 <=> H2O2 + IC-asc-DeltaC9-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30822", "l": "allantoin + H2O <=> allantoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18035", "l": "4-hydroxybenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => benzoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102666", "l": "indole-3-acetyl-beta-4-D-glucose hydrolase activity"}, {"i": "MetaCyc:RXN-3164"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866941", "l": "MID1IP1 binds THRSP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2464822", "l": "RDH12 reduces atRAL to atROL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35037", "l": "4-aminobutanoate(out) => 4-aminobutanoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16110", "l": "ATP + beta-D-fructose 6-phosphate => ADP + beta-D-fructose 1,6-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952807", "l": "p-Y693-STAT4 dissociates after IL12:IL12R interaction (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198347", "l": "AKT phosphorylates BAD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2089971", "l": "Secretion of collagens (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977271", "l": "Expression of EBF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174058", "l": "Degradation of multiubiquitinated Cdh1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47401", "l": "3-oxo-(9Z-octadecenoyl)-CoA + CoA => (7Z)-hexadecenoyl-CoA + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28869", "l": "H(+)(out) + lactose(out) => H(+)(in) + lactose(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15568", "l": "an N-acyl-L-amino acid + H2O <=> a carboxylate + an L-alpha-amino acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36676", "l": "octacosanoyl-CoA + sphinganine => CoA + H(+) + N-(octacosanoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63563", "l": "angiotensin I + H2O <=> angiotensin II + L-histidyl-L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691131", "l": "CANDI binds CUL1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.36", "l": "\"Trihydroxypterocarpan dimethylallyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65163", "l": "benzoyl-CoA + hexan-2-ol <=> CoA + hexan-2-yl benzoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061896", "l": "all-trans retinol 3,4-desaturase activity"}, {"i": "RHEA:50292", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin]"}, {"i": "EC:1.14.19.53", "l": "\"All-trans-retinol 3,4-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16556", "l": "aldehydo-D-ribose 5-phosphate + L-lysyl-[protein] <=> H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56530", "l": "6-chloro-D-tryptophan + FAD + 2 H2O => chloride + D-tryptophan + FADH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16307", "l": "3-hydroxy-3-methylglutarate + CoA + H(+) => (3S)-hydroxy-3-methylglutaryl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018746", "l": "RHOQ binds effectors at the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50239", "l": "O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] <=> 17alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30035", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADH + O2 = benzene-1,2,4-triol + CO2 + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29281", "l": "H2O + menaquinone-8 + trimethylamine => H(+) + menaquinol-8 + trimethylamine N-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33516", "l": "2 5,6-dihydroxyindole + O2 => 2 H2O + 2 indole-5,6-quinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21365", "l": "H2O + N-(6-aminohexanoyl)-6-aminohexanoate => 2 6-aminohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009541", "l": "ESR1 binds to TFF1 gene promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "78.819800280251172", "identifiers": [{"i": "GO:0019900", "l": "kinase binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050062", "l": "long-chain-fatty-acyl-CoA reductase activity"}, {"i": "RHEA:15437", "l": "a long-chain fatty aldehyde + CoA + NADP(+) = a long-chain fatty acyl-CoA + H(+) + NADPH"}, {"i": "EC:1.2.1.50", "l": "\"Long-chain-fatty-acyl-CoA reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28421", "l": "(R)-carnitine + gamma-butyrobetainyl-CoA <=> (R)-carnitinyl-CoA + 4-(trimethylamino)butanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9640195", "l": "RRAGA,B hydrolyzes GTP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44400", "l": "3-demethylubiquinol-6 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39717", "l": "(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + A + 2 H2O => (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008964", "l": "phosphoenolpyruvate carboxylase activity"}, {"i": "RHEA:28370", "l": "oxaloacetate + phosphate = hydrogencarbonate + phosphoenolpyruvate"}, {"i": "EC:4.1.1.31", "l": "\"Phosphoenolpyruvate carboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675206", "l": "PEA15 binds MAPK monomers and dimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33916", "l": "4-(methylamino)butanoate + H2O + O2 => H2O2 + methylamine + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031875", "l": "type 4 proteinase activated receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51570", "l": "(25S)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33180", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O => 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2243937", "l": "PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606583", "l": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40168", "l": "hexadecanoyl-CoA + O2 => (2E)-hexadecenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018766", "l": "RHOU binds effectors at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61126", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + quercetin => kaempferol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12287", "l": "3-hydroxy-3-methylglutarate + succinyl-CoA <=> (3S)-hydroxy-3-methylglutaryl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57500", "l": "3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042901", "l": "arabinan transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65466", "l": "2-methylbutyl butanoate + CoA => 2-methylbutan-1-ol + butanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008035", "l": "high-density lipoprotein particle binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18203", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170159", "l": "Translocation of Cdc25 to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061761", "l": "alpha-latrotoxin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015571", "l": "N-acetylgalactosamine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675948", "l": "TNFRSF6B binds TNFSF6,14,15 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177937", "l": "Phosphorylation of EGFR by SRC kinase (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008767", "l": "UDP-galactopyranose mutase activity"}, {"i": "RHEA:24132", "l": "UDP-alpha-D-galactose = UDP-alpha-D-galactofuranose"}, {"i": "EC:5.4.99.9", "l": "\"UDP-galactopyranose mutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55823", "l": "a 7(1)-hydroxybacteriochlorophyllide d + H2O + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide d + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626549", "l": "IQGAPs bind CALM1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46434", "l": "(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + 2 H2O + 2 oxidized [adrenodoxin] => (25R)-4beta,26-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784735", "l": "PCSK9:LDLR bind to Clathrin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10926", "l": "trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide => cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000234", "l": "phosphoethanolamine N-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67095", "l": "ATP + docosanoate(in) + H2O <=> ADP + docosanoate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391372", "l": "GNRHR binds GNRH1,2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357904", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9611851", "l": "ADRB2 bind ADR,NAd (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015513", "l": "high-affinity secondary active nitrite transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39001", "l": "a 1-acyl-sn-glycero-3-phosphate + H(+) + L-serine => a 1-acyl-sn-glycero-3-phospho-L-serine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1449687", "l": "Corticosteroids bind to CBG in blood (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10247", "l": "4-fumarylacetoacetate + H2O <=> acetoacetate + fumarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047127", "l": "thiomorpholine-carboxylate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65303", "l": "2-oxoglutarate + chrodrimanin C + O2 <=> CO2 + H2O + succinate + verruculide A"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008881", "l": "glutamate racemase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373724", "l": "Nephrin binds NCK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2672302", "l": "Phosphorylated LEPR Binds SOCS3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17520", "l": "H2O + N-(long-chain-fatty-acyl)-L-glutamate <=> a long-chain fatty acid + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42116", "l": "5alpha-androstane-3alpha,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23330", "l": "2-cis,4-trans-xanthoxin + a 12'-apo-carotenal => a 9-cis-epoxycarotenoid + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202969", "l": "Caspase mediated cleavage of beta-catenin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13886", "l": "H2O + stipitatonate => CO2 + stipitatate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202510", "l": "Activation of TAK1-TAB2 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29184", "l": "menaquinol-8 + 2 O2 => 2 H(+) + menaquinone-8 + 2 superoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27655", "l": "2-oxobutanoate + H(+) + pyruvate => (S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76373", "l": "N-hydroxylation of 4-aminobiphenyl (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047514", "l": "1,3-beta-D-glucan phosphorylase activity"}, {"i": "MetaCyc:13-BETA-GLUCAN-PHOSPHORYLASE-RXN"}, {"i": "EC:2.4.1.97", "l": "\"1,3-beta-D-glucan phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035949", "l": "Defective B4GALT1 does not transfer Gal to the N-glycan precursor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-532549", "l": "MPI isomerises Fru6P to Man6P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17743", "l": "3-dehydroshikimate + H(+) + NADH => NAD(+) + shikimate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24363", "l": "2 H(+) + siroheme <=> Fe(2+) + sirohydrochlorin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65333", "l": "H(+) + NADPH + O2 + verruculide A => chrodrimanin E + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34159", "l": "acetyl-CoA + UDP-N-acetylbacillosamine = CoA + H(+) + UDP-N,N'-diacetylbacillosamine"}, {"i": "EC:2.3.1.203", "l": "\"UDP-N-acetylbacillosamine N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22472", "l": "(R)-pantetheine + ATP = ADP + D-pantetheine 4'-phosphate + H(+)"}, {"i": "EC:2.7.1.34", "l": "\"Pantetheine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190245", "l": "FGFR1b binds to FGF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50599", "l": "acetyl-CoA + N-terminal L-seryl-[histone H4] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H4]"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0045290", "l": "D-arabinose 1-dehydrogenase [NAD(P)+] activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264458", "l": "Proteasome mediated degradation of COP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57094", "l": "A + glutathione + methanethiol => AH2 + S-(methylsulfanyl)glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22350", "l": "imidazol-4-one + NH4(+) => 4-aminoimidazole + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218824", "l": "p-6Y-VEGFR2 binds FYN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30061", "l": "orotate + succinate => (S)-dihydroorotate + fumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42799", "l": "(9Z,12Z)-octadecadienoyl-CoA + cholesterol <=> cholesteryl (9Z,12Z)-octadecadienoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35410", "l": "H2O + medicarpin <=> 4'-methoxyisoflavan-2',4,7-triol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036082", "l": "extracellular phenylacetaldehyde-gated ion channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696267", "l": "RND3 binds GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-140806", "l": "SERPINC1 binds SERPINC1 activators (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443831", "l": "14-3-3-zeta binds Raf1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41599", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H(+) + NADH <=> (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53968", "l": "apo-[BtrI ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[BtrI ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40118", "l": "H2O + hexanoyl-CoA <=> CoA + H(+) + hexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35016", "l": "riboflavin(in) => riboflavin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985950", "l": "p-Y649-STAT5A, p-STAT5B dimerizes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21301", "l": "H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49385", "l": "(12R)-hydroxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => (12R),18-dihydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645481", "l": "TIFA oligomerization (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30529", "l": "ADP + ATP + 2 H(+) => H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60042", "l": "(2E)-3-methylhex-2-enoate + L-glutamine => H2O + N(2)-[(2E)-3-methylhex-2-enoyl]-L-glutaminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177284", "l": "PKA phosphorylates PDE4B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684806", "l": "Unknown kinase phosphorylates CLEC1B dimer:PDPN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730841", "l": "Phosphorylation and activation of VAV (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22900", "l": "(R)-acetoin + NAD(+) = diacetyl + H(+) + NADH"}, {"i": "EC:1.1.1.303", "l": "\"Diacetyl reductase ((R)-acetoin forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35884", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164500", "l": "Conformational changes in gp120 exposes gp41 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46951", "l": "GTP + S-adenosyl-L-methionine <=> N(7)-methyl-GTP + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56301", "l": "[thioredoxin]-dithiol + S-sulfanyl-L-cysteinyl-[protein] => [thioredoxin]-disulfide + H(+) + hydrogen sulfide + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58686", "l": "FADH2-C4alpha-hydroperoxide + NADP(+) => FAD + 2 H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40839", "l": "FAD + H(+) + nonanoyl-CoA = (2E)-nonenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030565", "l": "snRNA pseudouridylation guide activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57900", "l": "2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2 = adenosine in U6 snRNA + CO2 + formaldehyde + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-517674", "l": "p-S158,221-HuR binds mRNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62893", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA => 6 CO2 + 7 CoA + 2 H2O + nor-toralactone"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904492", "l": "Ac-Asp-Glu binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56965", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + pyruvate => a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626953", "l": "TNF-alpha:TNFR1 binds DENN/MADD (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28408", "l": "H(+) + phosphate + XDP => H2O + XTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30562", "l": "GTP + H2O <=> guanosine + H(+) + triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66673", "l": "4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) => 5,7-dihydroxy-4-methylphthalide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420977", "l": "Ca permeable AMPA receptor ligand binding (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32988", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => a carboxylate + H(+) + sn-glycero-3-phospho-1D-myo-inositol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388811", "l": "CD28 homodimer binds B7-1 homodimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44014", "l": "(9Z)-hexadecenoyl-(Kdo)2-lipid IVA + holo-[ACP] => (9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2129375", "l": "Elastin cross-linking by lysyl oxidase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111238", "l": "Formation of ADAR2  homodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32791", "l": "L-ectoine(in) = L-ectoine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1861789", "l": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.89"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-264615", "l": "Loading of acetylcholine in synaptic vesicles (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37330", "l": "ATP + H2O + L-methionyl-L-alanine(out) <=> ADP + H(+) + L-methionyl-L-alanine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695828", "l": "FLT3 binds type I TKI (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16628", "l": "acetyl-CoA + hydrogen sulfide <=> CoA + thioacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30496", "l": "N-hydroxy-L-valine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45034", "l": "4 [Fe(II)cytochrome c] + 5 H(+) + nitrite => 4 [Fe(III)cytochrome c] + H2O + hydroxylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63620", "l": "ATP + dodecanoate + holo-[ACP] = AMP + diphosphate + dodecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44665", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a fatty acid + a monoacyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34148", "l": "2-deoxy-L-scyllo-inosose + L-glutamine => 2-deoxy-scyllo-inosamine + 2-oxoglutaramate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64208", "l": "an N-(fatty acyl)-L-glutamine + H2O = a fatty acid + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936963", "l": "IRAK2 induces TRAF6 oligomerization (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65787", "l": "2 H(+) + monuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-(4-chlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015369", "l": "calcium:proton antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69299", "l": "CDT1 binds geminin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693243", "l": "RHOD translocates to the Golgi membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43077", "l": "erythrodiol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oleanolic aldehyde + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432946", "l": "PARVB/Affixin interacts with alpha PIX (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58082", "l": "docosanoate + glycerol + H(+) => 1-docosanoylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32952", "l": "sucrose => trehalulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56944", "l": "AH2 + D-ribulose 5-phosphate = 1-deoxy-D-xylulose 5-phosphate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373073", "l": "Receptors CCR1, 2 and 8 bind CCL16 ligand (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64727", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (7S,14S)-dihydroperoxy-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000112", "l": "Endosomal TCII:Cbl translocates to lysosome (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061752", "l": "telomeric repeat-containing RNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31578", "l": "8-oxo-dGTP + H2O <=> 8-oxo-dGMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9008822", "l": "PPM1D dephosphorylates RUNX2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-167408", "l": "The high affinity receptor complex binds to G-protein (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008924", "l": "malate dehydrogenase (quinone) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65116", "l": "2-oxoglutarate + aculene B + O2 = aculene A + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9017797", "l": "NOTCH3 binds YBX1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43149", "l": "adenosine(9) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23011", "l": "alpha,alpha-trehalose 6-phosphate + H2O <=> D-glucose + D-glucose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042263", "l": "neuropeptide F receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72663", "l": "De novo formation of eIF2:GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64961", "l": "dTDP + H2O => dTMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062206", "l": "manoyl oxide synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046027", "l": "phospholipid:diacylglycerol acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57674", "l": "2beta-hydroxy-5-epi-aristolochene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-5-epi-aristolochene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110311", "l": "POLZ extends translesion synthesis (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687284", "l": "DMBT1 binds SFTPD 12mer, SFTPAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785607", "l": "FANCM binds FAAP24 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804527", "l": "INTL1 binds bacterial glycans (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61031", "l": "itaconate + L-cysteinyl-[protein] <=> S-(2,3-dicarboxypropyl)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58897", "l": "4-hydroxybutanoate + ATP + CoA => 4-hydroxybutanoyl-CoA + ADP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10226", "l": "ADP + H(+) + pyridoxal 5'-phosphate => ATP + pyridoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45350", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + sphing-4-enine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810076", "l": "DDO oxidizes D-Asp to OA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30262", "l": "2 a menaquinol + O2 <=> 2 a menaquinone + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41586", "l": "4-O-dimethylallyl-L-tyrosine + diphosphate => dimethylallyl diphosphate + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45178", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40404", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013711", "l": "HES1 gene expression is stimulated by NOTCH4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52555", "l": "3-dehydro-L-erythronate + ATP <=> 3-dehydro-4-O-phospho-L-erythronate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21763", "l": "(3S)-3-hydroxybutanoyl-CoA <=> (3R)-3-hydroxybutanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799431", "l": "TP53 binds HIPK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37951", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42562", "l": "pseudouridine(27/28) in mitochondrial tRNA => uridine(27/28) in mitochondrial tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.183"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876789", "l": "CARNMT1 methylates CARN to Anserine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2167942", "l": "Collagen type XIII ectodomain shedding (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663194", "l": "Some pathogenic BRCA1 mutants do not bind BARD1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14187", "l": "2-phenylacetaldehyde + CO2 => 3-phenylpyruvate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30588", "l": "2-demethylmenaquinol-8 + dimethyl sulfoxide => 2-demethylmenaquinone-8 + dimethyl sulfide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21554", "l": "CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086083", "l": "SUMOylation of ING2 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52170", "l": "8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64323", "l": "(9Z)-hexadecenoyl-CoA + cholesterol <=> cholesteryl (9Z)-hexadecenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4570528", "l": "SUMOylation of XPC with SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52296", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928624", "l": "EPHBs bind EFNBs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736979", "l": "p-2S-SMAD2,3:SMAD4:SP1 binds CDKN2B gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17972", "l": "ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44091", "l": "ATP + CoA + heptanoate <=> AMP + diphosphate + heptanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.29"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389352", "l": "Translocation of Vav1 to CD28 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0070529", "l": "L-tryptophan aminotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706308", "l": "Active FLT3 binds to GRB10 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39780", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36297", "l": "D-maltose + phosphate => alpha-maltose 6'-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62024", "l": "campesteryl 3-beta-D-glucoside + H2O = campesterol + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51730", "l": "dihydroxyacetone + phosphate => dihydroxyacetone phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4647594", "l": "SAHF formation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684241", "l": "Recruitment of Spike trimer to assembling virion (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44462", "l": "a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49845", "l": "(-)-dehydrodiconiferyl acid + a quinone => (-)-dehydrodiconiferyl acid ketone + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-917841", "l": "Acidification of Tf:TfR1 containing endosome (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70501", "l": "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30349", "l": "ADP + ITP => ATP + IDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34645", "l": "3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + 2 H(+) + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + squalene"}]}
{"type": "biolink:MolecularActivity", "ic": "69.52434437680833", "identifiers": [{"i": "GO:0140359", "l": "ABC-type transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018739", "l": "4-hydroxybenzoyl-CoA thioesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694433", "l": "MIA2 binds PREB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35176", "l": "novobiocin(in) => novobiocin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4647593", "l": "EP400 binds CDKN1A promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28750", "l": "NH4(+)(in) <=> NH4(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10016", "l": "H2O + O-sinapoylcholine = choline + E-sinapate + H(+)"}, {"i": "EC:3.1.1.49", "l": "\"Sinapine esterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21119", "l": "D-maltose + phosphate <=> beta-D-glucose 1-phosphate + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35449", "l": "H(+) + NADPH + norsolorinic acid => (1'S)-averantin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30363", "l": "fumonisin B1 + 2 H2O = (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 H(+) + 2 tricarballylate"}, {"i": "EC:3.1.1.87", "l": "\"Fumonisin B1 esterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047026", "l": "androsterone dehydrogenase (A-specific) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635845", "l": "GLI proteins bind CDC73 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42986", "l": "diphosphate + pimara-8(14),15-diene => (+)-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45198", "l": "5-methyltetrahydrosarcinapterin + [Co(I) corrinoid Fe-S protein] + H(+) => 5,6,7,8-tetrahydrosarcinapterin + [methyl-Co(III) corrinoid Fe-S protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60631", "l": "AH2 + gluconapin + O2 <=> A + H2O + xi-progoitrin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433823", "l": "Released NFkB complex migrates to the nucleus and turns on transcription (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047835", "l": "D-tryptophan N-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201457", "l": "BMP2 binds to the receptor complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61878", "l": "1-O-methyl-8-hydroperoxy-20-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668481", "l": "Protesomal degradation of K48polyUb-TRAF3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60461", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) => (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380316", "l": "Association of NuMA with microtubules (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199910", "l": "MSK1 activates ATF1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430135", "l": "p-SLP-76 binds ADAP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086200", "l": "Dentin matrix protein 1 binds integrin alphaVbeta3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46274", "l": "(4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 [Fe(III)-cytochrome b5] + 2 H2O => 2 [Fe(II)-cytochrome b5] + an N-acyl-(4R)-4-hydroxysphinganine + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446322", "l": "PARVA associates with Paxillin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18029", "l": "2 ATP + hydrogencarbonate + NH4(+) = 2 ADP + carbamoyl phosphate + 2 H(+) + phosphate"}, {"i": "EC:6.3.4.16", "l": "\"Carbamoyl-phosphate synthase (ammonia)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33462", "l": "H(+) + NADPH + zymosterone <=> 5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111962", "l": "PDE4A,C,D hydrolyse cAMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72671", "l": "eIF5B:GTP is hydrolyzed and released (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40997", "l": "4-hydroxybenzaldehyde + acetyl-CoA => 3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30320", "l": "H(+) + NADH + O2 + theobromine => 7-methylxanthine + formaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20683", "l": "H(+) + O-beta-D-glucosyl-cis-zeatin + UDP => cis-zeatin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928620", "l": "PAK1 autophosphorylates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53024", "l": "a plastoquinone + H2O + L-arginine = 5-guanidino-2-oxopentanoate + a plastoquinol + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44543", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.32"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451634", "l": "NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50142", "l": "(14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoate + H2O => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28313", "l": "beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose <=> alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5225649", "l": "RBBP7 binds histone H3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56175", "l": "FMN + O2 <=> 8-demethyl-8-formylriboflavin 5'-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22818", "l": "D-xylulose => D-xylose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27885", "l": "2',3'-cyclic CMP + H2O <=> 3'-CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35516", "l": "4'''-demalonylsalvianin + malonyl-CoA => CoA + salvianin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109700", "l": "AKT2 binds PIP3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17478", "l": "precorrin-6B + 2 S-adenosyl-L-methionine => CO2 + 3 H(+) + precorrin-8X + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433454", "l": "Phosphorylation of GAB2 by SFKs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23991", "l": "(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate <=> (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52346", "l": "(24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+) => (24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19908", "l": "NAD(+) + spermidine <=> dehydrospermidine + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801213", "l": "TP53 stimulates TRIAP1 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19132", "l": "ATP + thymidine <=> ADP + dTMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3640862", "l": "Tankyrase binds AXIN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047371", "l": "butyrate-acetoacetate CoA-transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981728", "l": "Factor H binds to membrane-associated C3b (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15527", "l": "1,4-dihydroxy-2-naphthoate + CoA => 2-succinylbenzoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44699", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H2O <=> a fatty acid + H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35966", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin A <=> fumitremorgin C + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102336", "l": "3-oxo-arachidoyl-CoA synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015441", "l": "ABC-type beta-glucan transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4608855", "l": "PRICKLE1 is degraded by the proteasome (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013147", "l": "RAC1 GDIs block activation of RAC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53238", "l": "cholesta-5,24Z-dien-3beta,27-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesta-5,24-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866941", "l": "MID1IP1 binds THRSP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10263", "l": "ATP + H2O + Mg(2+)(out) <=> ADP + H(+) + Mg(2+)(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675656", "l": "EDA:EDAR binds EDARADD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38335", "l": "(20S)-ginsenoside Rb1 + 2 H2O = (20S)-ginsenoside Rg3 + 2 D-glucose"}, {"i": "EC:3.2.1.192", "l": "\"Ginsenoside Rb1 beta-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850945", "l": "Casein kinase II phosphorylates PTEN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30613", "l": "AH2 + all-trans-neurosporene => A + all-trans-zeta-carotene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33782", "l": "6-kestotriose + sucrose <=> 6,6-kestotetraose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451482", "l": "activated MEK2 binds ERK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218891", "l": "RIPK1:RIPK3 oligomer binds MLKL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2545196", "l": "FN1 dimerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.85"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357904", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213201", "l": "Formation of collagen fibres (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57029", "l": "FADH2 + N-methylnicotinate + O2 => (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010473", "l": "GDP-galactose:myoinositol-1-phosphate guanylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061653", "l": "ISG15 conjugating enzyme activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46754", "l": "7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7alpha-hydroxycholest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004588", "l": "orotate phosphoribosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13791", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+) => [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000227", "l": "oxaloacetate secondary active transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678418", "l": "Defective ABCC9 (in KCNJ11:ABCC9) does not transport K+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678854", "l": "S1PR1 binds S1PR1 agonists (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41817", "l": "ganglioside GD3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GD2 (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63832", "l": "(6E)-8-methylnon-6-enoyl-CoA + vanillylamine = capsaicin + CoA + H(+)"}, {"i": "EC:2.3.2.35", "l": "\"Capsaicin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784765", "l": "p-Y705-STAT3 dimerizes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44661", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + sphing-4-enine => 1-O-alkyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39523", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA = (2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21127", "l": "cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine <=> 5-methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23994", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA => 1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1013020", "l": "Activation of GIRK/Kir3 Channels (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38274", "l": "(3S)-citramalyl-CoA <=> 3-methylfumaryl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58984", "l": "acrolein + H2O + O2 = acrylate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41748", "l": "3'-phosphoadenylyl sulfate + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol = 1,2-diacyl-3-(3-O-sulfo-beta-D-galactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391941", "l": "BLT receptors can bind LTB4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56257", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-threonyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112037", "l": "Inactivation of PLC beta (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928597", "l": "EPH:EFN dimers tetramerise (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72631", "l": "Formation of the cap-binding eIF4F complex (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928657", "l": "MMP2,9 cleave EPHB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050241", "l": "pyrroline-2-carboxylate reductase activity"}, {"i": "MetaCyc:PYRROLINE-2-CARBOXYLATE-REDUCTASE-RXN"}, {"i": "EC:1.5.1.1", "l": "\"1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NAD(P)H)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627369", "l": "SEPT4 binds XIAP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008336", "l": "gamma-butyrobetaine dioxygenase activity"}, {"i": "KEGG.REACTION:R02397"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055041", "l": "cyclopentanol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015661", "l": "L-lysine efflux transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613530", "l": "PRKAA2 phosphorylates PLINs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47472", "l": "(2E,4E)-tetradecadienoyl-CoA + H(+) + NADPH = (3E)-tetradecenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43477", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 => 10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27472", "l": "H2O + N,N'-diacetylchitobiose <=> acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62149", "l": "dGTP + dTMP => dGDP + dTDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428609", "l": "Type I Na+-coupled phosphate co-transport (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58187", "l": "H(+) + NADPH + 2 phytyl diphosphate <=> (14E,18E)-lycopadiene + 2 diphosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39014", "l": "a triacyl-sn-glycerol(in) <=> a triacyl-sn-glycerol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685838", "l": "CX3 complex binds D-loop structures (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23405", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate => diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166015", "l": "Association of LBP with LPS (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63637", "l": "a medium-chain fatty acyl-AMP + holo-[ACP] => a medium-chain fatty acyl-[ACP] + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42175", "l": "(11Z)-eicosenoyl-CoA + AH2 + O2 <=> (8Z,11Z)-eicosadienoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156930", "l": "GTP-binding activates eEF2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110360", "l": "Recruitment of POLB to the AP site (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0062186", "l": "anandamide epoxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.3", "l": "\"Microbial collagenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.12.12"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4088220", "l": "Endorepellin binds alpha2beta1 integrin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24077", "l": "a 3beta-hydroxy-Delta(5)-steroid + NAD(+) => a 3-oxo-Delta(5)-steroid + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604451", "l": "NOTCH4 binds FLT4 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29722", "l": "cob(I)alamin(in) <=> cob(I)alamin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15063", "l": "2 a Fe(III)-siderophore + NADH => 2 a Fe(II)-siderophore + H(+) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59186", "l": "2-acetylphloroglucinol + acetate => 2,4-diacetylphloroglucinol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63995", "l": "5-fluorocytidine + ATP <=> 5-fluorocytidine 5'-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6795460", "l": "SGK1 phosphorylates MDM2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183126", "l": "Factor B binds to surface-associated C3b (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164504", "l": "Synthesis of minus strand strong stop DNA (-sssDNA) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65183", "l": "AH2 + O2 + protoaustinoid B <=> A + H2O + preaustinoid A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928657", "l": "MMP2,9 cleave EPHB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64409", "l": "H(+)(out) + N-acetylmuramyl-L-alanyl-D-isoglutamine(out) => H(+)(in) + N-acetylmuramyl-L-alanyl-D-isoglutamine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10692", "l": "6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone"}, {"i": "EC:1.3.3.11", "l": "\"Pyrroloquinoline-quinone synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451811", "l": "YKI binds to WTS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56396", "l": "[(3R)-hydroxybutanoate](n) + H2O = (3R)-hydroxybutanoate trimer + [(3R)-hydroxybutanoate](n-3) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193695", "l": "IRAK interacts with TRAF6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24335", "l": "3alpha-hydroxy-3,5-dihydromonacolin L carboxylate <=> H2O + monacolin L carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0001884", "l": "pyrimidine nucleoside binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5679239", "l": "ULK complex translocates to the ER (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948063", "l": "hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186780", "l": "PI3-kinase binds to the active receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932334", "l": "KEAP1:CUL3:RBX1:NFE2L2 dissociates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64915", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O <=> a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9669893", "l": "KIT binds type I TKIs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694522", "l": "Inner coat assembly and cargo binding (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64239", "l": "atrochrysone carboxyl-[ACP] + H2O <=> atrochrysone carboxylate + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5140741", "l": "WNT5A binds FZD and ROR receptors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28156", "l": "alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59721", "l": "D-maltohexaono-1,5-lactone + H2O => D-maltohexaonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18740", "l": "ATP + H2O + hydrogenselenide <=> AMP + 2 H(+) + phosphate + selenophosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199093", "l": "CXADR binds to AMICA1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388596", "l": "Melanocortin receptors bind melanocortins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374919", "l": "Noradrenaline clearance from the synaptic cleft (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60072", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2 = 4beta-hydroxymethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45131", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60079", "l": "4beta-hydroxymethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2 <=> 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981657", "l": "IL34 dimer binds PTPRZ1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162657", "l": "Inactivation of Myt1 kinase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0035091", "l": "phosphatidylinositol binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35760", "l": "8-O-methylsterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => aflatoxin B1 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007464", "l": "The PRC1L4 complex binds the UXT gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029680", "l": "Caspase-7 translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854738", "l": "CSF3 dimer:CSFR binds CSFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174235", "l": "Association of Emi1 with Cdc20 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41746", "l": "a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64050", "l": "CoA + H(+) + N-(13Z-docosenoyl)-sphinganine => (13Z)-docosenoyl-CoA + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-622420", "l": "NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043716", "l": "2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18687", "l": "2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+) => H(+) + NADPH + O2 + pentachlorophenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140618", "l": "ferric-chelate reductase (NADH) activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990272", "l": "anti-Mullerian hormone receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680248", "l": "Phosphorylation of extracellular domain KIT mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13461", "l": "3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + H(+) + NADPH + O2 = 2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73577", "l": "CAD hexamer transforms L-Gln to CAP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3791319", "l": "NID1 degradation by MMP19 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34793", "l": "formate + H(+) + hydroxymethylphosphonate => 2-hydroxyethylphosphonate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23230", "l": "H2O + N(6)-hydroxy-L-lysine + NADP(+) => L-lysine + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9656244", "l": "DRD2 binds DA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696815", "l": "ELAC2 cleaves the 3' end of pre-tRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2025890", "l": "Calcineurin binds NFATC1,2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-167415", "l": "G-protein alpha subunit is inactivated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430183", "l": "NCK binds PAK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48723", "l": "aurachin B + H2O + NAD(+) <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15361", "l": "dolichyl phosphate + UDP-alpha-D-xylose = dolichyl D-xylosyl phosphate + UDP"}, {"i": "EC:2.4.2.32", "l": "\"Dolichyl-phosphate D-xylosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1254291", "l": "ERBB4s80 binds STAT5A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867041", "l": "EGFR phosphorylates EPS15 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13401", "l": "(2E,6E)-farnesol = (2Z,6E)-farnesol"}, {"i": "EC:5.2.1.9", "l": "\"Farnesol 2-isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868236", "l": "BAR domain proteins recruit dynamin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371537", "l": "DBC1 binds SIRT1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42895", "l": "5'-deoxyadenosine + H(+) + H2O <=> 5'-deoxyinosine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57381", "l": "(S)-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] => (13S,14R)-1,13-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2172123", "l": "Interaction of SIGLEC14/15/16 and DAP12 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432054", "l": "Aquaporin-1 passively transports water out of cell (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51413", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => (8R)-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56082", "l": "[Rab1 protein]-O-phosphocholine-L-serine + CMP + H(+) => [Rab1 protein]-L-serine + CDP-choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.10", "l": "\"Ribonuclease IX\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534388", "l": "Progesterone Activation Of CatSper (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48523", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + H2O <=> [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + H(+) + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000074", "l": "TCII binds Cbl in the circulation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11533", "l": "glycine + H2O + O2 => glyoxylate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24741", "l": "(6R)-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54735", "l": "N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983427", "l": "Expression of peptide bound class I MHC on cell surface (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24227", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP(+) <=> 4-methylcatechol + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43550", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47881", "l": "dioctanoylglycerol + H2O => H(+) + octanoate + octanoylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139906", "l": "Activation of BAD by calcineurin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10472", "l": "(2R,3S)-2,3-dimethylmalate = propanoate + pyruvate"}, {"i": "EC:4.1.3.32", "l": "\"2,3-dimethylmalate lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.41"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549304", "l": "OCT3 mediates renal clearance of organic cations (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939082", "l": "RUNX1 binds the CR1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35989", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51113", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19580", "l": "luteolin + UDP-alpha-D-glucose <=> H(+) + luteolin 7-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42686", "l": "L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide => H2O + L-gamma-glutamyl-hercynylcysteine S-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21563", "l": "3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol <=> 1,4-dithiothreitol + 2,3-epoxyphylloquinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11394", "l": "1D-myo-inositol 1,3,4-trisphosphate + phosphate => 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204861", "l": "Interaction of Tie2 and Shc1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008431", "l": "vitamin E binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43570", "l": "3,6-anhydro-L-galactonate + 2 H(+) + NADH => 3,6-anhydro-alpha-L-galactopyranose + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.37"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5658435", "l": "RAS GAPs bind RAS:GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190265", "l": "FGFR4 binds to FGF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5218805", "l": "PKC autophosphorylates (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0019191", "l": "cellobiose transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42536", "l": "uridine(65) in tRNA = pseudouridine(65) in tRNA"}, {"i": "EC:5.4.99.26", "l": "\"tRNA pseudouridine(65) synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59144", "l": "10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201669", "l": "Beta-catenin translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34498", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41489", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30155", "l": "FADH2 + 2 Fe(3+) = FAD + 2 Fe(2+) + 3 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45215", "l": "[Co(I) corrinoid Fe-S protein] + acetyl-CoA + H(+) <=> [methyl-Co(III) corrinoid Fe-S protein] + CO + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21934", "l": "homoserine lactone + S-methyl-5'-thioadenosine => S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434003", "l": "LPS binding to CD14 co-receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13496", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) <=> (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.16"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247839", "l": "Retromer associates with WLS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65605", "l": "(4R)-hydroxysphinganine + eicosanoyl-CoA => CoA + H(+) + N-eicosanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33698", "l": "C20 sphinganine + NADP(+) <=> 3-oxoeicosasphinganine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12882", "l": "ADP-alpha-D-glucose + sn-glycerol 3-phosphate => 2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661980", "l": "F8 variant is not secreted (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814409", "l": "CK2 phosphorylates PDCL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.2.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429529", "l": "Thrombin binding to GP1b:IX:V (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14280", "l": "(S)-lactaldehyde + H2O + NAD(+) <=> (S)-lactate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802934", "l": "p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9007901", "l": "IL1F10 binds IL1RL2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928657", "l": "MMP2,9 cleave EPHB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61500", "l": "delphinidin + UDP-alpha-D-glucose = delphinidin 3-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102106", "l": "curcumin synthase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001072", "l": "galactomannan binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654623", "l": "Activated FGFR3 binds FRS3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805785", "l": "AKT phosphorylates PHF20 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15974", "l": "3'-phosphoadenylyl sulfate + estrone => adenosine 3',5'-bisphosphate + estrone 3-sulfate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48343", "l": "a medium chain fatty acid + ATP + CoA <=> a medium-chain fatty acyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.99"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20106", "l": "ADP + beta-D-fructose 6-phosphate => AMP + beta-D-fructose 1,6-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64362", "l": "(3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O => (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420911", "l": "Formation of PPAT dimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61352", "l": "ATP + H2O + riboflavin(in) = ADP + H(+) + phosphate + riboflavin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54679", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (+)-kolavenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48995", "l": "1,3,7-trimethylurate + H(+) + NADH + O2 <=> 1,3,7-trimethyl-5-hydroxyisourate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375384", "l": "Bombesin-like receptors bind bombesin homologues (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47480", "l": "deoxycholate + NADP(+) = 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210872", "l": "Trans-phosphorylation of Tie2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624953", "l": "ARL13B binds INPP5E (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34726", "l": "15-methylhexadecasphing-4-enine 1-phosphate + H2O <=> 15-methylhexadecasphing-4-enine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63765", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018808", "l": "RAC3 binds effectors at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14363", "l": "3-methyl-2-butenal + H2O2 + L-cysteine => H2O + O2 + S-prenyl-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30555", "l": "GTP + L-glutamate + oxidized coenzyme F420-0 = GDP + H(+) + oxidized coenzyme F420-1 + phosphate"}, {"i": "EC:6.3.2.31", "l": "\"Coenzyme F420-0:L-glutamate ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48962", "l": "[thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O => [thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52233", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 => 3 A + Fe(2+) + 3 H2O + mycobilin a"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857555", "l": "EGFR phosphorylates GPNMB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38734", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433456", "l": "Recruitment of STATs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071885", "l": "N-terminal protein N-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211910", "l": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58398", "l": "3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NH4(+) + 4 oxidized [2Fe-2S]-[ferredoxin] => 4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + 5 H(+) + O2 + 4 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35949", "l": "chanoclavine-I aldehyde + H(+) + NADPH => dihydrochanoclavine-I aldehyde + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17751", "l": "AH2 + quinolin-2(1H)-one => A + H2O + quinoline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374663", "l": "DCC interaction with Ezrin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669855", "l": "Dasatinib-resistant KIT mutants do not bind dasatinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174157", "l": "Degradation of multiubiquitinated Cyclin B (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65097", "l": "a 2-acylglycerol + hexadecanoyl-CoA => a 1-hexadecanoyl-2-acylglycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4331327", "l": "E2F1 binds PMAIP1 (NOXA) promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28395", "l": "L-alanyl-L-glutamate => L-alanyl-D-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30578", "l": "3 menaquinone-8 + protoporphyrinogen IX <=> 3 menaquinol-8 + protoporphyrin IX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33550", "l": "H2O + lanosteryl hexadecanoate <=> H(+) + hexadecanoate + lanosterol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000286", "l": "alanine dehydrogenase activity"}, {"i": "RHEA:18405", "l": "H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate"}, {"i": "EC:1.4.1.1", "l": "\"Alanine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27276", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH => 2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57785", "l": "1,4-dinitrobenzene + NADH + O2 => 4-nitrocatechol + H(+) + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60296", "l": "L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.369", "l": "\"[Histone H3]-lysine(27) N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31144", "l": "(3S)-hydroxyhexanoyl-CoA + NAD(+) => 3-oxohexanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22139", "l": "7(1)-hydroxychlorophyllide a + H(+) + NADPH + O2 <=> chlorophyllide b + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0015292", "l": "uniporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102247", "l": "malonyl-malonyl acyl carrier protein-condensing enzyme activity"}, {"i": "MetaCyc:RXN-12361"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848335", "l": "IL37 binds  IL18R1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23124", "l": "2 (2R)-3-phosphoglycerate + 2 H(+) = CO2 + D-ribulose 1,5-bisphosphate + H2O"}, {"i": "EC:4.1.1.39", "l": "\"Ribulose-bisphosphate carboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42457", "l": "4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol => 5alpha-cholesta-8,24-dien-3beta-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29210", "l": "a menaquinol(in) + dimethyl sulfoxide(out) <=> a menaquinone(in) + dimethyl sulfide(out) + H2O(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13530", "l": "(3S)-citramalate => H2O + mesaconate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388817", "l": "ICOS binds ICOSL/B7-H2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48958", "l": "[thyroglobulin]-3-iodo-L-tyrosine + 2 H2O => [thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13623", "l": "1-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucose => 4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4720432", "l": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28933", "l": "4-carboxy-2-hydroxy-cis,cis-muconate => (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45683", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphate(in) <=> N-(hexadecanoyl)-sphing-4-enine-1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985201", "l": "ABCE1 binds RNASEL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602466", "l": "Activation of MT-MMPs by FURIN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53060", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate = estrone 4-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102805", "l": "codeine O-demethylase activity"}, {"i": "RHEA:27413", "l": "2-oxoglutarate + codeine + O2 = CO2 + formaldehyde + morphine + succinate"}, {"i": "EC:1.14.11.32", "l": "\"Codeine 3-O-demethylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36283", "l": "1,7-dimethylxanthine + H(+) + NADPH + O2 = 7-methylxanthine + formaldehyde + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21319", "l": "H2O + phorbol 12,13-dibutanoate <=> butanoate + H(+) + phorbol 13-butanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53484", "l": "androst-4-ene-3,11,17-trione + H(+) + NADPH = 17beta-hydroxyandrost-4-ene-3,11-dione + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102954", "l": "dalcochinase activity"}, {"i": "MetaCyc:RXN-9162"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193767", "l": "Influx of 24-hydroxycholesterol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807585", "l": "BPI binds LPS on the bacterial surface (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018660", "l": "4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15717", "l": "daunorubicin + H(+) + NADPH + O2 = doxorubicin + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2167942", "l": "Collagen type XIII ectodomain shedding (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5246478", "l": "APOM binds retinoids (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428273", "l": "SPHK1 phosphorylates SPG to S1P (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63632", "l": "a long-chain fatty acyl-AMP + holo-[ACP] = a long-chain fatty acyl-[ACP] + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196773", "l": "COASY phosphorylates DP-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65282", "l": "alpha-NeuNAc-(2->3)-beta-D-Gal-(1->3)-[alpha-NeuNAc-(2->6)]-alpha-D-GalNAc-(1<->1')-L-Ser-[protein] + CMP + H(+) => alpha-NeuNAc-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1<->1')-L-Ser-[protein] + CMP-N-acetyl-beta-neuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61115", "l": "(2R,3R)-dihydrokaempferol + O2 + reduced [NADPH--hemoprotein reductase] <=> (2R,3R)-dihydroquercetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37538", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210805", "l": "Removal of miRNA passenger strand (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22913", "l": "L-valine + pyruvate => 3-methyl-2-oxobutanoate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5444523", "l": "Formation of MSH1:PMS2 Complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34821", "l": "curcumin + H(+) + NADPH => dihydrocurcumin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33680", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + N-tetracosanoylsphinganine + O2 => 2 [Fe(III)-cytochrome b5] + H2O + N-tetracosanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029468", "l": "Conversion of PA into DAG by PAP-1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35127", "l": "L-alanyl-D-glutamate(out) = L-alanyl-D-glutamate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9646468", "l": "mTORC1 binds RHEB:GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186773", "l": "PDGF dimer binds two receptors simultaneously (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.61", "l": "\"Caspase-8\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70501", "l": "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55904", "l": "7-chloro-L-tryptophan + chloride + FADH2 + O2 = 6,7-dichloro-L-tryptophan + FAD + 2 H2O"}, {"i": "EC:1.14.19.60", "l": "\"7-chloro-L-tryptophan 6-halogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11441", "l": "2,3,5,6-tetrachlorophenol + NADPH + O2 => 2,3,5,6-tetrachlorohydroquinone + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56561", "l": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose => [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030732", "l": "methionine S-methyltransferase activity"}, {"i": "RHEA:13761", "l": "L-methionine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine"}, {"i": "EC:2.1.1.12", "l": "\"Methionine S-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20373", "l": "ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA"}, {"i": "EC:6.2.1.17", "l": "\"Propionate--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45957", "l": "(9Z)-octadecenoyl-CoA(in) => (9Z)-octadecenoyl-CoA(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34632", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced [adrenodoxin] => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25591", "l": "D-threo-isocitrate + NADP(+) <=> (S)-oxalosuccinate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18463", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11263", "l": "H(+) + NADPH + O2 <=> H2O2 + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694462", "l": "ABHD6,12 hydrolyse 3AG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60664", "l": "H2O + NADPH = NADH + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913374", "l": "Phosphorylated SHC1 recruits SHIP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67002", "l": "3 CO2 + 4 CoA + phlorisobutanophenone => 2-methylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975097", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043887", "l": "melibiose:sodium symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139909", "l": "Translocation of BMF to mitochondria (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3785684", "l": "Fibronectin degradation by CTSG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031616", "l": "EGR binds ARC gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112755", "l": "SOCS3 binds IL6ST (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17991", "l": "ADP + H(+) + O-phospho-L-seryl-[protein] => ATP + L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3095889", "l": "MMACHC reduces Cbl (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64013", "l": "acetyl-CoA + AH2 + 3 malonyl-CoA + 3 S-adenosyl-L-methionine => A + 3 CO2 + 4 CoA + fumigermin + H2O + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68595", "l": "ORC2 binds ORC3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2430552", "l": "p-S62-ARPP19/p-S67-ENSA binds PP2A-PPP2R2D (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "65.22986710590574", "identifiers": [{"i": "GO:0044877", "l": "protein-containing complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167117", "l": "Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32632", "l": "erythromycin D + H(+) + NADPH + O2 => erythromycin C + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797100", "l": "CCNK binds CDK13 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24202", "l": "aniline + CO2 => 4-aminobenzoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54976", "l": "(3S)-hydroxytetradecanoyl-CoA + H2O = (3S)-hydroxytetradecanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306953", "l": "GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16251", "l": "beta-D-glucose 6-phosphate => alpha-D-glucose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.53", "l": "\"[Myosin-light-chain] phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48626", "l": "(5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49202", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate => D-mannose 6-phosphate + H2O + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450474", "l": "MK2 phosphorylates BRF1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114560", "l": "Adhesion of integrin alphaIIbbeta3 to fibrin network (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16095", "l": "(24R)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21366", "l": "2 6-aminohexanoate => H2O + N-(6-aminohexanoyl)-6-aminohexanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102345", "l": "3-hydroxy-lignoceroyl-CoA dehydratase activity"}, {"i": "MetaCyc:RXN-13304"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58201", "l": "2-oxoglutarate + 6-aminohexanoate => 6-oxohexanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071618", "l": "lysophosphatidylethanolamine acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102926", "l": "solanidine glucosyltransferase activity"}, {"i": "MetaCyc:RXN-8882"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376141", "l": "Interaction of ABL with ROBO1:SLIT2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48378", "l": "a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+) => a neolactoside nLc4Cer + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047759", "l": "butanal dehydrogenase activity"}, {"i": "MetaCyc:BUTANAL-DEHYDROGENASE-RXN"}, {"i": "EC:1.2.1.57", "l": "\"Butanal dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16642", "l": "a long-chain fatty acyl ethyl ester + H2O => a long-chain fatty acid + ethanol + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102384", "l": "19-O-beta-glucopyranosyl-steviol glucosyltransferase activity"}, {"i": "MetaCyc:RXN-13521"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177922", "l": "EGFR dimerization (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201443", "l": "Type II receptor phosphorylates type I receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49047", "l": "H(+) + NADH + O2 + protoasukamycin <=> 4-hydroxyprotoasukamycin + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0042625", "l": "ATPase-coupled ion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51663", "l": "an N-(1,2-saturated acyl)sphinganine + H(+) + NADPH + O2 <=> an N-(2-hydroxyacyl)-sphinganine + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37018", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102031", "l": "4-acetamido-4,6-dideoxy-D-galactose transferase activity"}, {"i": "RHEA:28759", "l": "beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose = alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP + H(+)"}, {"i": "EC:2.4.1.325", "l": "\"TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.2.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64887", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + UMP <=> (6S)-5,6,7,8-tetrahydrofolate + 5-methyl-UMP + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008733", "l": "L-arabinose isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003796", "l": "lysozyme activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265987", "l": "Phosphorylation of BRCA1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26124", "l": "FAD + L-proline = (S)-1-pyrroline-5-carboxylate + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52732", "l": "3'-phosphoadenylyl sulfate + an 11-hydroxyjasmonate = adenosine 3',5'-bisphosphate + an 11-sulfojasmonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879221", "l": "PSTPIP1 binds Pyrin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29374", "l": "dAMP + H2O <=> 2'-deoxyadenosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797100", "l": "CCNK binds CDK13 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433418", "l": "Phosphorylation of JAK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.18", "l": "\"Meprin A\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71495", "l": "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132096", "l": "Formation of C4b:factor B complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.95", "l": "\"Tocopherol C-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213239", "l": "Formation of MHC II alpha beta heterodimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204863", "l": "Interaction of Tie2 with Ang2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24008", "l": "ATP + hypotaurocyamine = ADP + H(+) + N(omega)-phosphohypotaurocyamine"}, {"i": "EC:2.7.3.6", "l": "\"Hypotaurocyamine kinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103102", "l": "UDP-glucose:8-methylthiooctylhydroximate S-glucosyltransferase activity"}, {"i": "MetaCyc:RXNQT-4327"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052891", "l": "aliphatic (S)-hydroxynitrile lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50430", "l": "dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine => methanethiol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635843", "l": "GLI translocates to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61210", "l": "H(+) + nitrite + S-(guanosine 3',5'-cyclic phosphate)-L-cysteinyl-[protein] => 8-nitro-cGMP + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63355", "l": "2 H(+) + O2 + octadecanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] <=> (9Z)-octadecenoyl-CoA + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.-", "l": "\"Acting on carbohydrates and derivatives\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57306", "l": "glycolate + GMP + H(+) => H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43649", "l": "H(+) + hexadecanoyl-CoA + malonyl-[ACP] => 3-oxooctadecanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19381", "l": "(S)-oxalosuccinate + H(+) = 2-oxoglutarate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.25.2", "l": "\"HslU--HslV peptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11687", "l": "methylarsonous acid + S-adenosyl-L-methionine <=> dimethylarsinate + 2 H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36347", "l": "N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine"}, {"i": "EC:4.1.3.44", "l": "\"tRNA 4-demethylwyosine synthase (AdoMet-dependent)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24790", "l": "(2E,4Z)-2-hydroxy-6-oxononadienedioate + H2O => (2E)-2-hydroxypenta-2,4-dienoate + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44312", "l": "1-tetradecanoylglycerol + H2O = glycerol + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21469", "l": "dTDP-alpha-D-mycaminose + tylactone => 5-O-beta-D-mycaminosyltylactone + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15295", "l": "H(+) + methylarsonate + S-adenosyl-L-homocysteine => arsenite + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49579", "l": "AH2 + GTP + S-adenosyl-L-methionine <=> (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10208", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg)"}, {"i": "EC:2.3.2.8", "l": "\"Arginyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354066", "l": "Translocation of PTK2 to Focal complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46709", "l": "2-hydroxybenzoyl-5'-AMP + holo-[non-ribosomal peptide synthase] => AMP + H(+) + salicyl-[non-ribosomal peptide synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57771", "l": "2-nitrotoluene + NADH + O2 <=> 3-methylcatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18411", "l": "4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH => 4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-141437", "l": "Formation of the MCC complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730903", "l": "Oligomerization of TRAF6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51285", "l": "(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45857", "l": "3-hydroxytetradecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(2-hydroxytridecyl)-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062060", "l": "NuA4 histone acetyltransferase complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-213406", "l": "Disassociation of PLC-gamma1 from LAT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35792", "l": "2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-kanosamine => H(+) + kanamycin X + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6795667", "l": "MDM2 translocates to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466834", "l": "Defective OPN1SW causes tritanopia (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684267", "l": "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052788", "l": "d-4,5 unsaturated beta-glucuronyl hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690196", "l": "USP8 deubiquitinates RNF128 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28169", "l": "5-nitroanthranilate + H(+) + H2O <=> 5-nitrosalicylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38219", "l": "(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1972385", "l": "ADP-Ribosylation of HNP-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25274", "l": "ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57047", "l": "D-apionate + NAD(+) <=> 3-oxoisoapionate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58286", "l": "H(+) + NADPH + thymine => 5,6-dihydrothymine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218815", "l": "p-6Y-VEGFR2 binds NCK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17717", "l": "1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508451", "l": "PTK2B is phosphorylated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22393", "l": "(9Z,12Z)-octadecadienoate + O2 => (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60374", "l": "D-fructose(in) => D-fructose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19213", "l": "acetyl-CoA + an S-substituted L-cysteine = an N-acetyl-L-cysteine-S-conjugate + CoA + H(+)"}, {"i": "EC:2.3.1.80", "l": "\"Cysteine-S-conjugate N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2514790", "l": "Elastin degradation by MMP14 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48818", "l": "17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38351", "l": "(R)-3-phenyllactate + NAD(+) = 3-phenylpyruvate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29918", "l": "L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose <=> alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932033", "l": "KCTD6 gene expression is stimulated by RUNX1 and ESR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373746", "l": "SEMA4D interacts with CD45 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61590", "l": "ADP + amicoumacin A 2-phosphate + H(+) => amicoumacin A + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39322", "l": "(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH <=> (8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24277", "l": "acetate + diphosphate => acetyl phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53399", "l": "dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] <=> 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187303", "l": "SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170986", "l": "Ral-GDS binds to Ras-GTP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66999", "l": "2-methylpentanoate + ATP + CoA <=> 2-methylpentanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28895", "l": "cadaverine(in) + L-lysine(out) = cadaverine(out) + L-lysine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8941701", "l": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783552", "l": "OSM binds LIFR:JAKs,OSMR:JAKs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28343", "l": "dITP + H2O => dIMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.-", "l": "\"Carboxy-lyases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029456", "l": "RAC1 and CDC42 activate PAK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602473", "l": "Autocatalytic activation of MMP1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66478", "l": "gypsogenate 28-beta-D-glucoside + UDP => gypsogenate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77094", "l": "Formation of cap binding complex (CBC) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56828", "l": "2,3,6-trichlorohydroquinone + chloride + glutathione disulfide = 2,3,5,6-tetrachlorohydroquinone + 2 glutathione"}, {"i": "RHEA:56832", "l": "2,6-dichlorohydroquinone + chloride + glutathione disulfide + H(+) = 2,3,6-trichlorohydroquinone + 2 glutathione"}, {"i": "EC:1.21.4.5", "l": "\"Tetrachlorohydroquinone reductive dehalogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45846", "l": "3-oxooctanoyl-CoA + H(+) + NADPH => (3R)-hydroxyoctanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32288", "l": "(2R,3S)-3-isopropylmalate => (2S)-2-isopropylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48911", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004744", "l": "retinal isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17683", "l": "2-methyl-3-oxopropanoate + H(+) + NADH => 3-hydroxy-2-methylpropanoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47954", "l": "[prokaryotic ubiquitin-like protein]-C-terminal-L-glutamate + NH4(+) => [prokaryotic ubiquitin-like protein]-C-terminal-L-glutamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682967", "l": "WHSC1 binds DNA DSBs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187697", "l": "TRKA recruits RIT and RIN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62342", "l": "(+)-malbrancheamide C + FADH2 => (+)-premalbrancheamide + bromide + FAD + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050555", "l": "2-hydroxypropyl-CoM lyase activity"}, {"i": "RHEA:19421", "l": "(R)-2-hydroxypropyl-coenzyme M = (R)-1,2-epoxypropane + coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13428", "l": "a pyrimidine ribonucleoside 5'-phosphate + H2O <=> a pyrimidine nucleobase + D-ribose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50968", "l": "adenosine(37) in tRNA(Ala) + H(+) + H2O = inosine(37) in tRNA(Ala) + NH4(+)"}, {"i": "EC:3.5.4.34", "l": "\"tRNA(Ala)(adenine(37)) deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49078", "l": "dibenzothiophene 5-oxide + FMN + H(+) + H2O => dibenzothiophene + FMNH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25559", "l": "9alpha-copalyl diphosphate <=> diphosphate + stemod-13(17)-ene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63140", "l": "H2O + N-tetracosanoyl-taurine = taurine + tetracosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48052", "l": "n 3'-phosphoadenylyl sulfate + dermatan = n adenosine 3',5'-bisphosphate + dermatan 4'-sulfate + n H(+)"}, {"i": "EC:2.8.2.35", "l": "\"Dermatan 4-sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5339535", "l": "GLTPD1 transports C1P from plasma membrane to Golgi membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77068", "l": "Activation of GT (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430347", "l": "MigFilin associates with Filamin and F-actin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51465", "l": "deoxycholate + O2 + reduced [NADPH--hemoprotein reductase] => 1beta-hydroxydeoxycholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810843", "l": "Envoplakin binds periplakin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011966", "l": "Estrogen-responsive KDM4B gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050332", "l": "thiamine pyridinylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61949", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl-[protein] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046175", "l": "Further sulfation on galactose residues produces KSPG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17333", "l": "O-acetyl-L-serine + zeatin = acetate + H(+) + L-lupinate"}, {"i": "EC:2.5.1.50", "l": "\"Zeatin 9-aminocarboxyethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52283", "l": "(6S)-5,6,7,8-tetrahydrofolate + 3-O-methylgallate <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4,5-trihydroxybenzoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39320", "l": "(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH => (8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8960973", "l": "RLBP1:11cRAL dissociates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5444516", "l": "Formation of MSH2:MSH6 Complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57067", "l": "D-apionolactone + H2O <=> D-apionate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28099", "l": "ATP + GDP => AMP + guanosine 3',5'-bis(diphosphate)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45195", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035180", "l": "Expression of EEPD1 regulated by NR1H2 or NR1H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38829", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000112", "l": "Endosomal TCII:Cbl translocates to lysosome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23029", "l": "malonyl-[ACP] + N(6)-biotinyl-L-lysyl-[protein] => acetyl-[ACP] + N(6)-carboxybiotinyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64797", "l": "H2O + L-lysine + NADP(+) => (S)-2-amino-6-oxohexanoate + H(+) + NADPH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21834", "l": "3',5-dihydroxy-3,4',7-trimethoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65503", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + AH2 + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + A + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55962", "l": "AMP + diphosphate + gamma-butyrobetainyl-CoA => 4-(trimethylamino)butanoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174786", "l": "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712078", "l": "ALK mutants bind PI3KR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102949", "l": "1,2-rhamnosyltransferase activity"}, {"i": "MetaCyc:RXN-9082"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870461", "l": "RABGGTA and RABGGTB bind (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5622134", "l": "CRABP1 binds atRA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65582", "l": "H(+) + phosphate + TDP => H2O + TTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.20.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22655", "l": "2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + H2O <=> 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004047", "l": "aminomethyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710254", "l": "GSDME oligomerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1606273", "l": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4088134", "l": "PLK1 phosphorylates FOXM1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805109", "l": "CDK2 phosphorylates TP53 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24807", "l": "2-(1-hydroxyethyl)thiamine diphosphate + pyruvate => (2S)-2-acetolactate + thiamine diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36180", "l": "1-O-alkyl-2-acyl-sn-glycerol + CDP-choline => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25941", "l": "8-chloroquinoline + A + H2O => 8-chloroquinolin-2(1H)-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53504", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine = 5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate"}, {"i": "EC:4.1.99.23", "l": "\"5-hydroxybenzimidazole synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047866", "l": "dimethylglycine oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59675", "l": "D-maltotriose + O2 <=> D-maltotriono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170706", "l": "Phosphorylation of  NEFL by the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45665", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193661", "l": "PRDM4 translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55381", "l": "a 3alpha-hydroxy bile acid CoA + NAD(+) => a 3-oxo bile acid CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20058", "l": "2 H(+) + H2O + N-carbamoylsarcosine => CO2 + NH4(+) + sarcosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17251", "l": "6 H(+) + 2 iron(III) oxide-hydroxide => 2 Fe(2+) + 2 H2O + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614618", "l": "Persulfide sulfur is transferred onto sulfite (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204779", "l": "Interaction of Tie2 with Ang1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43677", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678854", "l": "S1PR1 binds S1PR1 agonists (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53715", "l": "2 Fe(III)-heme b <=> beta-hematin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15023", "l": "4-O-feruloyl-D-quinate + CoA => (E)-feruloyl-CoA + L-quinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13689", "l": "diphosphate + glycerol = glycerol 1-phosphate + H(+) + phosphate"}, {"i": "EC:2.7.1.79", "l": "\"Diphosphate--glycerol phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53330", "l": "2,3-diacyl-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP => H2O + UDP-2,3-diacyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21614", "l": "2-dehydro-3-deoxy-D-gluconate + H2O => D-gluconate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-606289", "l": "New CENPA-containing nucleosomes are deposited at the centromere (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60441", "l": "H2O + methyl acetate => acetate + H(+) + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624956", "l": "PDE6D binds INPP5E (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050011", "l": "itaconyl-CoA hydratase activity"}, {"i": "RHEA:13785", "l": "citramalyl-CoA = H2O + itaconyl-CoA"}, {"i": "EC:4.2.1.56", "l": "\"Itaconyl-CoA hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58732", "l": "5-methyl-CTP + H2O = 5-methyl-CMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809309", "l": "MTMR6 binds MTMR9 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42387", "l": "4,4'-diaponeurosporenal + H2O + NAD(+) <=> 4,4'-diaponeurosporenoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38704", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40838", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2 H2O <=> 2 (9Z)-octadecenoate + 2 H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679044", "l": "FKBP1A binds sirolimus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59786", "l": "(2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADPH => H2O + NADP(+) + pseudopaline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665989", "l": "DIAPH1 binds RHOA:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951595", "l": "CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14403", "l": "chlordecone + H(+) + NADPH => chlordecone alcohol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50215", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate <=> 11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9612219", "l": "ERBB4s80 binds to SRC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13647", "l": "D-glucono-1,5-lactone + H(+) + NADPH => beta-D-glucose + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30892", "l": "O-acetyl-L-serine + thiosulfate => acetate + H(+) + S-sulfo-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59791", "l": "H2O + NAD(+) + pseudopaline <=> (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16445", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone = daidzein + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853801", "l": "PSPN binds RET:GFRA4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19428", "l": "H(+) + imidazole-4-acetate + NADH + O2 <=> 5-hydroxyimidazole-4-acetate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43412", "l": "a D-galactosylceramide + H2O = an N-acyl-sphingoid base + D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40230", "l": "3'-phosphoadenylyl sulfate + desulfo-A47934 <=> A47934 + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913675", "l": "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26421", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 <=> (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25671", "l": "sucrose + UDP-alpha-D-galactose => H(+) + loliose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655849", "l": "Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626981", "l": "TNF-alpha:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944457", "l": "MAF1 translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29160", "l": "3 a menaquinol(in) + 2 H(+)(out) + nitrite(out) => 3 a menaquinone(in) + 2 H2O(out) + NH4(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76386", "l": "CYP1A2 S-demethylates 6MMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0016726", "l": "oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"}, {"i": "EC:1.17.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674427", "l": "PDGFR mutants bind type I TKIs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37305", "l": "ADP + glycyl-L-asparagine(in) + H(+) + phosphate => ATP + glycyl-L-asparagine(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805943", "l": "S100A1 binds TLR4:LY96 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1013881", "l": "Cables1 links CDK2 and WEE1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17419", "l": "ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate => ATP + N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35465", "l": "5alpha-cholest-7-en-3-one + H(+) + NADH => 5alpha-cholest-7-en-3beta-ol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30532", "l": "biotinate sulfoxide + H(+) + NADH => biotin + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602383", "l": "Defective MyD88 does not oligomerize within the activated TLR2/4 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15162", "l": "4-hydroxyphenylacetate + H(+) + NADH + O2 => H2O + homogentisate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38440", "l": "(9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14632", "l": "ATP + N-acetyl-L-glutamate <=> ADP + N-acetyl-L-glutamyl 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34085", "l": "a (3S)-3-hydroxyacyl-CoA => a (3R)-3-hydroxyacyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047905", "l": "fructose-6-phosphate phosphoketolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53850", "l": "7-oxo-taurodeoxycholate + H(+) + NADH => NAD(+) + taurocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190260", "l": "FGFR2b binds to FGF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983374", "l": "p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9619756", "l": "NR1H2 binds ABCA1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036042", "l": "long-chain fatty acyl-CoA binding"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0004457", "l": "lactate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73596", "l": "dCMP + H2O => dUMP + NH4+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53413", "l": "(1R,4S)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 => (4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086076", "l": "gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102440", "l": "3',4',5'-trimethylmyricetin 3-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-13918"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49208", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,24S-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392202", "l": "Dissociation of the P2Y purinoceptor 12:Gi complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69074", "l": "Formation of Processive Complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004144", "l": "diacylglycerol O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24764", "l": "UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate = UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate"}, {"i": "EC:5.1.3.23", "l": "\"UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098750", "l": "FYXD domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200396", "l": "Creatine transport across the plasma membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34341", "l": "(20R,22R)-20,22-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin] => 22R-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70613", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28561", "l": "D-fructose 6-phosphate + H2O <=> D-fructose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784598", "l": "NPPA(124-151) binds NPR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25541", "l": "ent-copalyl diphosphate => diphosphate + ent-pimara-8(14),15-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25749", "l": "2 H(+) + H2O + N-hydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase] => L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395412", "l": "Phosphorylation of SYK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17050", "l": "3-demethylubiquinol-9 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43381", "l": "H2O + N(omega)-phospho-L-arginyl-[protein] => L-arginyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443774", "l": "Trans-homodimerization of Neurofascin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211874", "l": "CYP2S1 4-hydroxylates atRA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3780997", "l": "PPP1R3C binds to glycogen:GYG2:GYS2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102845", "l": "1-18:3-2-16:0-monogalactosyldiacylglycerol desaturase activity"}, {"i": "MetaCyc:RXN-8307"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20666", "l": "1,5-anhydro-D-glucitol + NADP(+) => 1,5-anhydro-D-fructose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380586", "l": "loading of Serotonin in synaptic vesicles (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12363", "l": "(2E)-2-methylbut-2-enoyl-CoA + 13-hydroxylupanine <=> 13-(2-methylcrotonoyloxy)lupanine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2012074", "l": "FGFR3c P250R mutant binds to ligand with enhanced affinity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047164", "l": "isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862733", "l": "CCR2, CCR3 bind CCL13 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614591", "l": "Excess cysteine yields lanthionine and H2S (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9606151", "l": "Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12000", "l": "formate + NADP(+) = CO2 + NADPH"}, {"i": "EC:1.17.1.10", "l": "\"Formate dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218829", "l": "VEGF induces CDC42 activation by unknown mechanism (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015230", "l": "FAD transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16309", "l": "H2O + taurochenodeoxycholate = chenodeoxycholate + taurine"}, {"i": "EC:3.5.1.74", "l": "\"Chenodeoxycholoyltaurine hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177922", "l": "EGFR dimerization (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37570", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine <=> 1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51266", "l": "(10bS,4aR)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47505", "l": "chenodeoxycholate + NADP(+) => 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389762", "l": "Phosphorylation of PD-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876240", "l": "CBL binds InlB-activated MET (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56572", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose = globoside Gb3Cer + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17553", "l": "ATP + guanidinoethyl methyl phosphate = ADP + H(+) + N'-phosphoguanidinoethyl methylphosphate"}, {"i": "EC:2.7.3.7", "l": "\"Opheline kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14154", "l": "17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP-N-acetyl-alpha-D-glucosamine => 17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucosiduronate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30662", "l": "4-(phosphooxy)-L-threonine + H2O <=> 4-hydroxy-L-threonine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29482", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-epicubenol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985594", "l": "MYO9B inactivates RHOA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61398", "l": "ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] => ATP + N(6)-(D-erythrulosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66377", "l": "D-erythrose 4-phosphate + H2O => D-erythrose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9611839", "l": "β3-agonists bind ADRB3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54604", "l": "2-oxoglutarate + decanoyl-CoA + O2 = 2-hydroxydecanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45036", "l": "3 [Fe(III)cytochrome c] + hydroxylamine = 3 [Fe(II)cytochrome c] + 3 H(+) + nitric oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3247836", "l": "Retromer recycles WLS to the Golgi (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10735", "l": "ATP + firefly D-luciferin + O2 <=> AMP + CO2 + diphosphate + firefly oxyluciferin + hnu"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19523", "l": "acetyl phosphate + CoA => acetyl-CoA + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9688838", "l": "RIPK3 binds STUB1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49790", "l": "CoA + glycochenodeoxycholate + H(+) => chenodeoxycholoyl-CoA + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66487", "l": "16alpha-hydroxygypsogenate + UDP-alpha-D-glucose <=> 16alpha-hydroxygypsogenate 28-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352268", "l": "Cleavage of Satb1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024161", "l": "FTSJ1 2'-O-methylates guanosine-34 in tRNA(Phe) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177942", "l": "EGFR binds EGF ligand (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0047555", "l": "3',5'-cyclic-GMP phosphodiesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042009", "l": "interleukin-15 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36163", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate"}, {"i": "EC:6.3.4.21", "l": "\"Nicotinate phosphoribosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5695980", "l": "ACAD10 dehydrogenates S-2MPDA-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000327", "l": "PLK1 phosphorylates BORA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018392", "l": "glycoprotein 3-alpha-L-fucosyltransferase activity"}, {"i": "MetaCyc:2.4.1.214-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418200", "l": "SRC-1 bound to ARRB2 is not activated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0098519", "l": "nucleotide phosphatase activity, acting on free nucleotides"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190682", "l": "Connexin synthesis (generic) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17150", "l": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] => an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39016", "l": "22-oxodocosanoate + H2O + NAD(+) => docosanedioate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047451", "l": "3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40448", "l": "(2R)-pristanoyl-CoA => (2S)-pristanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11380", "l": "2-oxoglutarate + [2-(trimethylamino)ethyl]phosphonate + O2 = [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + CO2 + succinate"}, {"i": "EC:1.14.11.72", "l": "\"(2-(trimethylamino)ethyl)phosphonate dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16145", "l": "2 [Fe(II)-cytochrome b5] + CMP-N-acetyl-beta-neuraminate + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + CMP-N-glycoloyl-beta-neuraminate + H2O"}, {"i": "EC:1.14.18.2", "l": "\"CMP-N-acetylneuraminate monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30461", "l": "(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + acetone => (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390438", "l": "FAR2 reduces PalmCoA to HXOL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30565", "l": "7-(3-methylbut-2-enyl)-L-tryptophan + diphosphate => dimethylallyl diphosphate + L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74059", "l": "PDE6 hydrolyses cGMP to GMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616243", "l": "CEBPA gene transcription is enhanced by RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, MYB, LEF1, and CEBPA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36294", "l": "3-methylxanthine + H(+) + NADPH + O2 <=> formaldehyde + H2O + NADP(+) + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983424", "l": "Budding of COPII coated vesicle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683735", "l": "mRNA9 is translated to Nucleoprotein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14795", "l": "2-oxoadipate + H(+) + NADH => 2-hydroxyadipate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8858500", "l": "CLEC10A binds Tn-MUC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694527", "l": "Loss of SAR1B GTPase (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629918", "l": "NEIL1 translocates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051744", "l": "3,8-divinyl protochlorophyllide a 8-vinyl reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645535", "l": "ALPK1 phosphorylates TIFA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71590", "l": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10541", "l": "7,8-dihydroneopterin => 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802912", "l": "High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8939204", "l": "ESTG binds ESR1:chaperone complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47909", "l": "6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O => 6-deoxy-6-sulfo-D-gluconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981809", "l": "ST6GALNAC3/4 can add a sialic acid to the sialyl T antigen to form the disialyl T antigen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59135", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP <=> AMP + diphosphate + H(+) + staphyloferrin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45329", "l": "7,8-dihydroneopterin => 7,8-dihydromonapterin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37901", "l": "7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate => 2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74885", "l": "GUCYs converts GTP to cGMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51473", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5336182", "l": "GPR37 binds prosaptide (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047221", "l": "sn-glycerol-3-phosphate 2-alpha-galactosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9012835", "l": "GDIs block activation of RHOA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373074", "l": "Receptor CCR9  binds CCL25 ligand (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380930", "l": "Phosphorylated AMPK binds AMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52850", "l": "5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine => 5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938108", "l": "SERPINB13 binds cathepsin L (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45733", "l": "D-ribulose 5-phosphate + L-tyrosine => (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453200", "l": "SYK autophosphorylates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27617", "l": "(2Z,6E)-farnesyl diphosphate + 10 isopentenyl diphosphate <=> di-trans,deca-cis-tridecaprenyl diphosphate + 10 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070855", "l": "myosin VI head/neck binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56688", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 = (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate"}, {"i": "EC:1.14.20.9", "l": "\"Tyrosine isonitrile desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009977", "l": "proton motive force dependent protein transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28293", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (5S,9S,10S)-drim-7-en-11-ol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-419166", "l": "GEFs activate RhoA,B,C (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5668545", "l": "NIK autophosphorylates on T559 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45913", "l": "a (2E,4E)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63045", "l": "H2O + mevastatin => H(+) + mevinic carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47042", "l": "5-taurinomethyl-2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein] => 5-taurinomethyluridine(34) in tRNA + AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141439", "l": "Release of activated MAD2 from kinetochores (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15464", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) <=> 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351936", "l": "Caspase-mediated cleavage of claspin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801666", "l": "PLK2 phosphorylates CENPJ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62757", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38383", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205321", "l": "Interaction of KIT and sSCF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033948", "l": "fructan beta-(2,1)-fructosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683801", "l": "CHEK2 phosphorylates BRCA1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59416", "l": "H2O + O2 + tryptamine = H2O2 + indole-3-acetaldehyde + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013006", "l": "RHOA:GTP translocates to the ER membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32208", "l": "(2E,4Z)-2-hydroxyhexa-2,4-dienedioate => (3Z)-2-oxohex-3-enedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156661", "l": "Formation of Exon Junction Complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27924", "l": "4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) + phosphate => 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201608", "l": "Caspase-mediated cleavage of alpha adducin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48189", "l": "(9Z,12Z)-octadecadienoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26214", "l": "9alpha-copalyl diphosphate + H2O => aphidicolan-16beta-ol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61415", "l": "ATP + N-(D-erythrulosyl)-cadaverine <=> ADP + H(+) + N-(3-O-phospho-D-erythrulosyl)-cadaverine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421222", "l": "inosine 5'-monophosphate (IMP) + NAD+ + H2O => xanthosine 5'-monophosphate (XMP) + NADH + H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16125", "l": "ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1878002", "l": "XYLTs transfer Xyl to core protein (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130731", "l": "Formation of COPII vesicle (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213200", "l": "Release of endostatin-like peptides (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63354", "l": "(9Z)-octadecenoyl-CoA + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + octadecanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24585", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H2O + NAD(+) => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111956", "l": "Calmodulin activates Cam-PDE 1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24079", "l": "a 3beta-hydroxy-Delta(5)-steroid + NAD(+) <=> a 3-oxo-Delta(5)-steroid + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176175", "l": "Stalling of DNA replication fork and RPA binding (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.-", "l": "\"Linked to the hydrolysis of a nucleoside triphosphate\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66616", "l": "Mg(2+)(in) + 2 Na(+)(out) = Mg(2+)(out) + 2 Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34282", "l": "di-trans,poly-cis-dolichol + NADP(+) <=> di-trans,cis-polyprenol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9724685", "l": "IgE binds omalizumab (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264458", "l": "Proteasome mediated degradation of COP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42013", "l": "cortisol + NAD(+) => 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55197", "l": "2-hydroxyoctadecanoyl-CoA => formyl-CoA + heptadecanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61124", "l": "kaempferol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + quercetin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19233", "l": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein]"}, {"i": "EC:3.1.2.22", "l": "\"Palmitoyl-protein hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24849", "l": "3-dehydroshikimate => 3,4-dihydroxybenzoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63516", "l": "biphenyl-2,2',3-triol + H(+) + NADH + O2 = biphenyl-2,2',3,3'-tetraol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103036", "l": "NADH:menaquinone oxidoreductase activity"}, {"i": "MetaCyc:RXN0-5388"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664346", "l": "IL10 gene produces IL10 protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41439", "l": "(9Z)-octadecenoyl-CoA + cholesterol <=> cholesteryl (9Z-octadecenoate) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389350", "l": "Activation of Cdc42 by pVav1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693012", "l": "TNFSF15 binds TNFRSF25 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21005", "l": "(R)-pantolactone + A => 2-dehydropantolactone + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35682", "l": "dodecanoyl-CoA + H(+) + L-serine <=> 3-oxotetradecasphinganine + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51587", "l": "gamma-butyrobetainyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> crotonobetainyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41207", "l": "1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21850", "l": "(Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide => (E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682983", "l": "ATM phosphorylates WHSC1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59398", "l": "D-leucine => L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003976", "l": "UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65413", "l": "dAMP(in) + NAD(+)(out) => dAMP(out) + NAD(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26362", "l": "L-tyrosine + NADPH + S-adenosyl-L-methionine => 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16755", "l": "3,8-divinyl protochlorophyllide a + 2 H2O + NADP(+) => Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202437", "l": "Phosphorylation of CARMA1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32337", "l": "(1S,4R)-fenchone + H(+) + NADPH => (1S,2S,4R)-endo-fenchol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0051981", "l": "copper chelate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213207", "l": "Formation of collagen networks (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18133", "l": "ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate"}, {"i": "EC:2.7.7.4", "l": "\"Sulfate adenylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64429", "l": "glycyl-L-proline(out) + H(+)(out) => glycyl-L-proline(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617828", "l": "TRIP11:IFT20 dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791323", "l": "TP53 stimulates BCL2L14 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052794", "l": "exo-alpha-(2->3)-sialidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696547", "l": "STAMBPL1 is a deubiquitinase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62026", "l": "campesterol + D-glucose => campesteryl 3-beta-D-glucoside + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811508", "l": "ING2-bound EP300 acetylates TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088220", "l": "Endorepellin binds alpha2beta1 integrin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48037", "l": "globoside Gb4Cer (d18:1(4E)) + H2O => globoside Gb3Cer (d18:1(4E)) + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51470", "l": "a quinol + pyruvate => (R)-lactate + a quinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694522", "l": "Inner coat assembly and cargo binding (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15732", "l": "D-mannonate + NAD(+) <=> H(+) + keto-D-fructuronate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18364", "l": "dolichyl D-xylosyl phosphate + L-seryl-[protein] <=> 3-O-(beta-D-xylosyl)-L-seryl-[protein] + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20033", "l": "isopenicillin N = penicillin N"}, {"i": "EC:5.1.1.17", "l": "\"Isopenicillin-N epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197963", "l": "DHFR2 reduces FOLA to DHF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13270", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O => an N-acylsphing-4-enine + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14064", "l": "H2O + N-(carboxymethyl)-D-alanine + NAD(+) <=> glycine + H(+) + NADH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047806", "l": "cytochrome-c3 hydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001165", "l": "RNA polymerase I cis-regulatory region sequence-specific DNA binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070016", "l": "armadillo repeat domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030233", "l": "deoxynucleotide transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22864", "l": "L-lysine = D-lysine"}, {"i": "EC:5.1.1.5", "l": "\"Lysine racemase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36233", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50412", "l": "L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein] = H(+) + N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu)"}, {"i": "RHEA:50420", "l": "L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein] = H(+) + N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu)"}, {"i": "EC:2.3.2.29", "l": "\"Aspartate/glutamate leucyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9658253", "l": "RAS:GTP binds PI3K (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.4", "l": "\"Fructokinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0051732", "l": "polyribonucleotide kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190520", "l": "Association of Golgi  transport vesicles with microtubules (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31672", "l": "dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine => dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140449", "l": "centromere-nuclear envelope anchor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47759", "l": "guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13348", "l": "(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] <=> diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14702", "l": "2 CoA + NAD(+) => CoA-disulfide + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16016", "l": "ATP + glycine + tRNA(Gly) <=> AMP + diphosphate + glycyl-tRNA(Gly)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655843", "l": "Expression of Fatty Acid Synthase (FASN) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801687", "l": "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564184", "l": "Collagen type IX degradation by MMP3,13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008457", "l": "beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity"}, {"i": "RHEA:23004", "l": "a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine = a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085083", "l": "Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097259", "l": "20-aldehyde-leukotriene B4 20-monooxygenase activity"}, {"i": "REACT:R-HSA-2161792", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807565", "l": "GNLY is transferred to the phagosome (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0008493", "l": "tetracycline transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "77.349316285872916", "identifiers": [{"i": "GO:0030247", "l": "polysaccharide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032217", "l": "riboflavin transmembrane transporter activity"}, {"i": "REACT:R-HSA-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Homo sapiens)"}, {"i": "RHEA:35015", "l": "riboflavin(in) = riboflavin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793057", "l": "NSUN4 methylates cytidine-841 of 12S rRNA yielding 5-methylcytidine-841 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18019", "l": "CO2 + indole-3-acetaldehyde => H(+) + indole-3-pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649701", "l": "NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56930", "l": "abieta-7,13-dien-18-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-al + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.98.-", "l": "\"With other, known, acceptors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63974", "l": "AH2 + pyriculol => A + dihydropyriculol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37115", "l": "sphing-4-enine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005123", "l": "death receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40770", "l": "(20S)-ginsenoside R1 + H2O <=> (20S)-ginsenoside Rg1 + D-xylose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047820", "l": "D-glutamate cyclase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17120", "l": "ATP + L-glutamate + methylamine <=> ADP + H(+) + N(5)-methyl-L-glutamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66234", "l": "H2O2 + IC-asc-DeltaC7-CoA => IC-asc-C7-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166753", "l": "Conversion of C4 into C4a and C4b (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48312", "l": "benzoyl-CoA + H(+) + NADPH + O2 = 2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+)"}, {"i": "EC:1.14.13.208", "l": "\"Benzoyl-CoA 2,3-epoxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251557", "l": "Expression of AMER1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18335", "l": "ADP + H(+) + oleandomycin 2'-O-phosphate => ATP + oleandomycin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17785", "l": "H(+) + L-glutamate = 4-aminobutanoate + CO2"}, {"i": "EC:4.1.1.15", "l": "\"Glutamate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.50", "l": "\"Lysyl endopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-561072", "l": "OCT3 mediates renal uptake of organic cations (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.28"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44640", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27520", "l": "phosphate + sphing-4-enine => H2O + sphing-4-enine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196857", "l": "PANK2 phosphorylates PanK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12966", "l": "ATP + D-galacturonate => 1-phospho-alpha-D-galacturonate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031177", "l": "phosphopantetheine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712086", "l": "ALK fusions phosphorylate PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013009", "l": "RHOA binds effectors at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5220959", "l": "TDG excises 5-formylcytosine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18630", "l": "ATP + NAD(+) => ADP + H(+) + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627369", "l": "SEPT4 binds XIAP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-437118", "l": "GPVI stimulates PI3K beta, gamma (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009072", "l": "STAT3 phosphorylation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647978", "l": "pro-RAS proteins are farnesylated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23363", "l": "L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose <=> alpha-D-glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-868658", "l": "1,4-alpha-glucan is converted to glucanotrehalose (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36542", "l": "hexadecanoyl-CoA + sphinganine <=> CoA + H(+) + N-hexadecanoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64478", "l": "4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate => 4-[(2E,7S,8E,10E,13R,14R,16E,18E)-14-ethyl-7,13-dihydroxy-2,16,18-trimethylicosa-2,8,10,16,18-pentaenoyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25246", "l": "(R)-S-lactoylglutathione + H2O => (R)-lactate + glutathione + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26311", "l": "1,4-dihydroxy-2-naphthoate + CoA + H(+) => 1,4-dihydroxy-2-naphthoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56997", "l": "aldehydo-D-apiose => apulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34569", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH => CDP-alpha-D-paratose + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48232", "l": "acetyl-CoA + L-glutamate 5-semialdehyde = CoA + H(+) + N-acetyl-L-glutamate 5-semialdehyde"}, {"i": "EC:2.3.1.271", "l": "\"L-glutamate-5-semialdehyde N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26140", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + H2O = 5-amino-6-(5-phospho-D-ribitylamino)uracil + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211715", "l": "Proteasome mediated degradation of PAK-2p34 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48762", "l": "H(+) + L-erythrulose + NADH => L-threitol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39079", "l": "(3S)-hydroxydodecanedioyl-CoA + NAD(+) = 3-oxododecanedioyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937807", "l": "SRC phosphorylates RUNX3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44152", "l": "1D-myo-inositol 2-phosphate + H2O = myo-inositol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902945", "l": "metalloendopeptidase activity involved in amyloid precursor protein catabolic process"}, {"i": "REACT:R-HSA-9010034", "l": "ADAM10:Zn2+:TSPANs cleaves APP(18-770) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49061", "l": "a long-chain alkane + FMNH2 + O2 => a long chain fatty alcohol + FMN + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.12.14"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191763", "l": "snRNP:Snurportin complex formation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1218833", "l": "Binding of ligand-responsive EGFR mutants to chaperoning proteins HSP90 and CDC37 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420202", "l": "Secretin receptor binds secretin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49971", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16237", "l": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)"}, {"i": "EC:5.2.1.8", "l": "\"Peptidylprolyl isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59562", "l": "H(+) + N,N',N''-triacetylchitotrionate => H2O + N,N',N''-triacetylchitotriono-1,5-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30709", "l": "4-aminobutanal + L-alanine => putrescine + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33561", "l": "a 2-acyl-sn-glycerol 3-phosphate + CoA => an acyl-CoA + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55164", "l": "a jasmonyl-L-isoleucinate + H(+) + NADPH + O2 = H2O + L-isoleucine-12-hydroxyjasmonate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868573", "l": "CDK5:p25 phosphorylates PRDX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9656891", "l": "OPN1SW binds 11cRAL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607750", "l": "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352059", "l": "SLC6A15-mediated amino acid uptake (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58867", "l": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52708", "l": "GMP + H2O = D-ribose 5-phosphate + guanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730752", "l": "NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5632738", "l": "DDIT4 binds 14-3-3 dimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19813", "l": "a 2-oxocarboxylate + L-asparagine = 2-oxosuccinamate + an L-alpha-amino acid"}, {"i": "RHEA:52528", "l": "2-oxoglutarate + L-asparagine = 2-oxosuccinamate + L-glutamate"}, {"i": "EC:2.6.1.14", "l": "\"Asparagine--oxo-acid transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59378", "l": "4-amino-4-deoxyprephenate => 4-amino-4-deoxychorismate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803890", "l": "SFN dimerizes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19266", "l": "carnitine + NAD(+) => 3-dehydrocarnitine + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102895", "l": "colneleate synthase activity"}, {"i": "MetaCyc:RXN-8496"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38018", "l": "delta-tocotrienol <=> 6-geranylgeranyl-2-methylbenzene-1,4-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59009", "l": "H2O + O2 + salicylaldehyde => H(+) + H2O2 + salicylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66241", "l": "ATP + CoA + IC-asc-C9 => AMP + diphosphate + IC-asc-C9-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59727", "l": "D-maltoheptaono-1,5-lactone + H2O <=> D-maltoheptaonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51759", "l": "a 2-acyl-4-prenylphloroglucinol + dimethylallyl diphosphate <=> a 2-acyl-4,6-diprenylphloroglucinol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32874", "l": "a 2-acylglycerol + H2O <=> a carboxylate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112514", "l": "JAK activation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047529", "l": "2,3-dimethylmalate lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10675", "l": "cyclobutadithymidine in DNA <=> a thymidine dimer in DNA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0023030", "l": "MHC class Ib protein binding, via antigen binding groove"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11741", "l": "2 glutathione + NADP(+) => glutathione disulfide + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35527", "l": "H(+) + N-ethylmaleimide + NADH = N-ethylsuccinimide + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.25", "l": "\"Bile acid CoA-transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64960", "l": "dTDP + H2O = dTMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64737", "l": "4-hydroxynonanal + NADP(+) => (E)-4-hydroxynon-2-enal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46135", "l": "cholesterol + H(+) + NADPH + O2 <=> 25-hydroxycholesterol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45113", "l": "gamma-tocopherol + H(+) + NADPH + O2 => 13-hydroxy-gamma-tocopherol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-168947", "l": "Ligand binds to TLR10 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11849", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine => [thioredoxin]-dithiol + glycine betaine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46781", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318415", "l": "ATF2 acetylates histone H2B, H4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43345", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+) => [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940959", "l": "Neurolysin degrades neurotensin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-976768", "l": "Factor H binds to C3b (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39687", "l": "(R)-3-hydroxy-(11Z)-octadecenoyl-CoA = (2E,11Z)-octadecadienoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015381", "l": "high-affinity sulfate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606159", "l": "BTK autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418456", "l": "cGMP is degraded by PDEs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48770", "l": "ADP + D-erythrulose 4-phosphate + H(+) => ATP + D-erythrulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420975", "l": "Ca impermeable AMPA receptor ligand binding (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165195", "l": "GTP loading by Rheb (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004934", "l": "mating-type alpha-factor pheromone receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5251942", "l": "Hikeshi binds HSP70s:ATP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18353", "l": "ATP + H2O + K(+)(out) + Na(+)(in) = ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate"}, {"i": "EC:7.2.2.13", "l": "\"Na(+)/K(+)-exchanging ATPase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31859", "l": "(S)-2,3-epoxysqualene = glutinol"}, {"i": "EC:5.4.99.49", "l": "\"Glutinol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60654", "l": "an N-(acyl)-sphingosyl-1,3-cyclic phosphate + choline => an N-(acyl)-sphingosylphosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029460", "l": "PAK1 phosphorylates LIMK1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670418", "l": "Phosphorylation of JAK2 downstream of KIT mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64165", "l": "2-methyl-L-serine => formaldehyde + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51005", "l": "2 [Fe(III)cytochrome cL] + a primary alcohol => 2 [Fe(II)cytochrome cL] + an aldehyde + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20418", "l": "coelenterazine + O2 => CO2 + coelenteramide + hnu"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8857686", "l": "FITM1, FITM2 bind TAGs (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848606", "l": "PTK6 phosphorylates PXN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51227", "l": "2 [Fe(III)cytochrome c] + S-sulfanyl-L-cysteinyl-[SoxY protein] + thiosulfate <=> 2 [Fe(II)cytochrome c] + 2 H(+) + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13679", "l": "D-xylulose 5-phosphate => D-ribulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11956", "l": "cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25030", "l": "ADP-D-ribose 1''-phosphate + H2O => ADP-D-ribose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13740", "l": "an n-alkanal + NADP(+) <=> an alk-2-enal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782820", "l": "USP17 deubiquitinates SUDS3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.16", "l": "\"Membrane Pro-Xaa carboxypeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9688838", "l": "RIPK3 binds STUB1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39716", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + AH2 + O2 => (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47801", "l": "4-methylsulfanyl-2-oxobutanoate + an aromatic L-alpha-amino acid => an aromatic oxo-acid + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16468", "l": "(R)-lactate + 2 [Fe(III)cytochrome c553] <=> 2 [Fe(II)cytochrome c553] + 2 H(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48998", "l": "2-hydroxy-6-oxo-2,4-heptadienoate + H(+) => 3-methylcatechol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17358", "l": "O2 + 2 R'C(R)SH => H2O2 + R'C(R)S-S(R)CR'"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626681", "l": "Recruitment of transition zone proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46127", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22210", "l": "H2O + homogentisate + NAD(+) => 3-hydroxyphenylacetate + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39597", "l": "(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+) => (2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034736", "l": "cholesterol O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36140", "l": "(E)-hexadec-2-enoate + ATP + CoA => (2E)-hexadecenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14275", "l": "4-aminobutanal + AH2 + propane-1,3-diamine => A + H2O + spermidine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008414", "l": "CDP-alcohol phosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38158", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (6E,10E)-geranyllinalool + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5333671", "l": "CLCAs self cleave (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684801", "l": "p-Y7-CLEC1B dimer:PDPN binds SYK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19795", "l": "formaldehyde + glycine + reduced [electron-transfer flavoprotein] => H(+) + H2O + oxidized [electron-transfer flavoprotein] + sarcosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29929", "l": "(R)-pantothenate(out) + Na(+)(out) => (R)-pantothenate(in) + Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141139", "l": "Trimerization of TRAIL:TRAIL receptor complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61127", "l": "kaempferol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + quercetin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134962", "l": "DHX36 binds DNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52580", "l": "ATP + H2O + Pb(2+)(in) = ADP + H(+) + Pb(2+)(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32452", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate => all-trans-phytoene + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60341", "l": "N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32416", "l": "(1S,2S,4R)-isodihydrocarveol + NAD(+) => (1S,4R)-isodihydrocarvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43463", "l": "dodecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-undecylpyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37342", "l": "3-(carbamoylamino)-2-methylpropanoate + 2 H(+) + H2O <=> (R)-3-amino-2-methylpropanoate + CO2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199935", "l": "MSK1 activates CREB (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218814", "l": "PAK2 autophorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426530", "l": "Laminins:Nidogens binds HSPG2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9664850", "l": "ATM binds PEX5 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9646685", "l": "Aggresome dissociates from dynein and microtubule (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9609310", "l": "β-blockers bind ADRB1,2,3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57542", "l": "5'-phospho-ribonucleosidyl-ribonucleotide-RNA + diphosphate + H(+) => 5'-NTP-ribonucleotide-RNA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863895", "l": "IKKB phosphorylates SNAP23 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47096", "l": "(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate"}, {"i": "EC:2.5.1.86", "l": "\"Trans,polycis-decaprenyl diphosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158982", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44225", "l": "16-hydroxyhexadecanoate + ATP + CoA => 16-hydroxyhexadecanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36057", "l": "a 2,4-dihydroxypteridine + NH4(+) => a 2-amino-4-hydroxypteridine + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37642", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA <=> 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444527", "l": "FPR is a receptor for formyl peptides (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20447", "l": "L-aspartate + prephenate => L-arogenate + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59396", "l": "L-leucine = D-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17019", "l": "(R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA => (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112755", "l": "SOCS3 binds IL6ST (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0008525", "l": "phosphatidylcholine transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50784", "l": "dodecanal + NADP(+) = (2E)-dodecenal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0045309", "l": "protein phosphorylated amino acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791118", "l": "Expression of ASNS (Asparagine Synthetase) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31834", "l": "(2E,6E)-farnesyl diphosphate <=> delta-guaiene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2730872", "l": "Activation of Calcineurin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50640", "l": "2-(2-methylsulfanyl)ethylmalate = 3-(2-methylsulfanyl)ethylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-140806", "l": "SERPINC1 binds SERPINC1 activators (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49247", "l": "NAD(+) + resolvin E1 <=> 18-oxo-resolvin E1 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655285", "l": "Activated FGFR3 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034778", "l": "2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21139", "l": "(R)-carnitine + acetyl-CoA <=> CoA + O-acetyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64995", "l": "acetyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-acetyl-4'-phosphopantetheine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006507", "l": "GRIN2A gene expression is stimulated by MECP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204813", "l": "Interaction of Tie2 and Grb14 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58922", "l": "(+)-medicarpin + H2O => (3S,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40611", "l": "H2O + trihexanoylglycerol = 2,3-dihexanoyl-sn-glycerol + H(+) + hexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55703", "l": "an inositol phosphomannosylinositol-1-phospho-N-acyl-(4R)-4-hydroxysphinganine + H2O <=> an N-acyl-(4R)-4-hydroxysphinganine + H(+) + mannosyldiinositol-1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690740", "l": "CD22 binds B-cell receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17934", "l": "a 7-hydroxyisoflavone + S-adenosyl-L-methionine => a 7-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67074", "l": "a very long-chain fatty acid + CoA + H(+) => a very long-chain fatty acyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64023", "l": "GTP + L-seryl-[protein] <=> GDP + H(+) + O-phospho-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25212", "l": "H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine <=> acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58287", "l": "5,6-dihydrothymine + NADP(+) <=> H(+) + NADPH + thymine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31761", "l": "dTDP-alpha-D-desosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine => dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37939", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65265", "l": "3-hydroxypentacecilide A + A => AH2 + chrodrimanin C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19366", "l": "ATP + D-ribulose 5-phosphate => ADP + D-ribulose 1,5-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33653", "l": "(9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate => (9Z,12Z)-octadecadienoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013009", "l": "RHOA binds effectors at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38958", "l": "an N-acylsphing-4-enine 1-phosphate(in) <=> an N-acylsphing-4-enine 1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047989", "l": "hydroxybutyrate-dimer hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38148", "l": "carbon disulfide + H2O => carbonyl sulfide + H(+) + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50399", "l": "(2-aminobenzoyl)acetate + H(+) + octanoyl-CoA <=> 2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944236", "l": "Association of procollagen type XIV (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65461", "l": "acetyl-CoA + hexan-1-ol => CoA + hexyl acetate"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0001793", "l": "IgM receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-429860", "l": "DCP1-DCP2 complex decaps mRNA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61145", "l": "myricetin + UDP-beta-L-rhamnose => H(+) + myricetin 3-O-alpha-L-rhamnoside + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004779", "l": "sulfate adenylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854222", "l": "TBC1D3 associates with RAB5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67090", "l": "ADP + H(+) + phosphate + tetracosanoate(out) => ATP + H2O + tetracosanoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199425", "l": "PHLPP dephosphorylates S473 in AKT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26104", "l": "(2R)-homocitrate <=> cis-homoaconitate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42182", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602466", "l": "Activation of MT-MMPs by FURIN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18860", "l": "lithocholate + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxylithocholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4093329", "l": "EFNBs bind SDCBP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39999", "l": "a sphingoid 1-phosphate = a fatty aldehyde + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53925", "l": "a secondary amine + S-adenosyl-L-methionine => a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839098", "l": "Activated FGFR1 mutants and fusions phosphorylate PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38475", "l": "L-histidine + S-adenosyl-L-methionine = H(+) + N(alpha)-methyl-L-histidine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42258", "l": "3-oxooctanoyl-[ACP] + CO2 + CoA => H(+) + hexanoyl-CoA + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51619", "l": "ATP + formate + H(+) <=> CO2 + dATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20711", "l": "ATP + erythritol <=> ADP + D-erythritol 4-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57592", "l": "(S)-pinocembrin + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-2-hydroxypinocembrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373074", "l": "Receptor CCR9  binds CCL25 ligand (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42308", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31890", "l": "(S)-2,3-epoxysqualene <=> tirucalladienol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389350", "l": "Activation of Cdc42 by pVav1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29868", "l": "AMP + ITP => ADP + IDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112342", "l": "Inactivation of MAP2K1 by CDK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64888", "l": "ATP + holo-[ACP] + tetradecanoate = AMP + diphosphate + tetradecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8979071", "l": "KDM6B binds iron (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60613", "l": "1-octanoyl-sn-glycero-3-phosphocholine => 1-octanoyl-sn-glycero-2,3-cyclic phosphate + choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685939", "l": "3a localizes to the cell membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47761", "l": "a uridine in 21S rRNA + S-adenosyl-L-methionine => a 2'-O-methyluridine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419334", "l": "Melatonin receptors can bind melatonin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40818", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1369052", "l": "ABCAs mediate lipid influx (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029273", "l": "PI3K binds to p-6Y-SYK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44564", "l": "4-hydroxybenzoate + all-trans-decaprenyl diphosphate = 4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10705", "l": "ATP + L-valine + tRNA(Val) => AMP + diphosphate + L-valyl-tRNA(Val)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65850", "l": "a steroid 1,3-dione + AH2 => A + a 3-oxo-Delta(1)-steroid + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046481", "l": "digalactosyldiacylglycerol synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77589", "l": "Recognition of AAUAAA sequence by CPSF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418904", "l": "A1 and A3 receptors bind adenosine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21863", "l": "3'-phosphoadenylyl sulfate + quercetin 3,3'-bissulfate <=> adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3',7-trissulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395992", "l": "p-T,4S-IRF3 is dimerized (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382057", "l": "Release of novel PDGFs as latent factors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2509827", "l": "ITPA hydrolyses ITP to IMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112342", "l": "Inactivation of MAP2K1 by CDK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18178", "l": "a 2,3-saturated acyl-CoA + NAD(+) => a (2E)-enoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69116", "l": "Formation of Okazaki fragments (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63831", "l": "L-alanine + vanillin <=> pyruvate + vanillylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430135", "l": "p-SLP-76 binds ADAP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33404", "l": "ATP + L-threonine => diphosphate + L-threonyl-5'-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14419", "l": "H(+) + N(6)-acetyl-L-lysine + phosphate => acetyl phosphate + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62532", "l": "2 [Fe(II)cytochrome c] + digitoxin + 3 H(+) = 2 [Fe(III)cytochrome c] + dihydrodigitoxin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61348", "l": "ATP + estrone 3-sulfate(in) + H2O = ADP + estrone 3-sulfate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-166015", "l": "Association of LBP with LPS (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63773", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939335", "l": "RNF181 polyubiquinates BCL10 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043858", "l": "arginine:ornithine antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46878", "l": "[(1->4)-beta-D-mannuronosyl](n+1) + GDP + H(+) => [(1->4)-beta-D-mannuronosyl](n) + GDP-alpha-D-mannuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45458", "l": "dodecanoate + ethanolamine => H2O + N-dodecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55390", "l": "(3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2 => (3R)-3-hydroxy-2,3-dihydrotabersonine + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928656", "l": "gamma-secretase cleaves EPHB2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047714", "l": "galactolipase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52468", "l": "16alpha,17beta-estriol + UDP-alpha-D-glucuronate = 16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391934", "l": "DP2 receptor can bind PGD2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22149", "l": "a plastoquinol + 2 H(+)(in) + 2 oxidized [plastocyanin] => a plastoquinone + 4 H(+)(out) + 2 reduced [plastocyanin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937369", "l": "ATAD2 binds ESR1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9007539", "l": "CHEK1 phosphorylates E2F6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209370", "l": "CI75 transports from the cytosol to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13251", "l": "2-oxopropyl-coenzyme M + H(+) + NADH => (R)-2-hydroxypropyl-coenzyme M + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29937", "l": "cytosine(out) + H(+)(out) => cytosine(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26263", "l": "2 H(+) + isopimarate + NADPH => H2O + isopimara-7,15-dienal + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24183", "l": "2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592387", "l": "Fibulin binds elastic fibres (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005457", "l": "GDP-fucose transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030749", "l": "loganate O-methyltransferase activity"}, {"i": "RHEA:12508", "l": "loganate + S-adenosyl-L-methionine = loganin + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.50", "l": "\"Loganate O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12417", "l": "beta-alanyl-CoA => acryloyl-CoA + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37794", "l": "aclacinomycin A + O2 <=> aclacinomycin Y + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140664", "l": "ATP-dependent DNA damage sensor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48304", "l": "a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60879", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40604", "l": "1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O => (9Z,12Z)-octadecadienoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036052", "l": "Defective NAGLU does not hydrolyse heparan chain(2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43108", "l": "2 [Fe(III)cytochrome c] + H2O + N2 = 2 [Fe(II)cytochrome c] + 2 H(+) + nitrous oxide"}, {"i": "EC:1.7.2.4", "l": "\"Nitrous-oxide reductase\""}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0036080", "l": "purine nucleotide-sugar transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53686", "l": "2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41719", "l": "a 2-acyl-sn-glycero-3-phospho-L-serine + H2O <=> a 2-acyl-sn-glycerol 3-phosphate + H(+) + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19083", "l": "a halide anion + a primary alcohol + H(+) => 1-haloalkane + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51205", "l": "6-trans-leukotriene B4 + NADP(+) => 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15894", "l": "Co-sirohydrochlorin + 2 H(+) => Co(2+) + sirohydrochlorin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176298", "l": "Activation of claspin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19037", "l": "an epoxide + H2O = an ethanediol"}, {"i": "EC:3.3.2.10", "l": "\"Soluble epoxide hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39728", "l": "a sphingomyelin(in) => a sphingomyelin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13533", "l": "H2O + medicarpin + NADP(+) = (3R)-vestitone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56498", "l": "gypsogenate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => gypsogenin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20032", "l": "10-deoxysarpagine + NADP(+) <=> H(+) + NADPH + vellosimine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40569", "l": "A + dTDP-beta-L-evernitrose + H2O => AH2 + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389580", "l": "formyl-CoA + H2O => formate + CoASH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37978", "l": "H(+) + homogentisate + phytyl diphosphate <=> 2-methyl-6-phytyl-1,4-benzene-1,4-diol + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450088", "l": "GLUT1 tetramer binds 4xATP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67009", "l": "a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030735", "l": "carnosine N-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2197690", "l": "Detachment of WASP/WAVE (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388605", "l": "POMC(138-176) binds MC2R (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34686", "l": "alpha-D-ribose 1-methylphosphonate 5-triphosphate + H2O <=> alpha-D-ribose 1-methylphosphonate 5-phosphate + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194036", "l": "Cortisol translocates from the mitochondrial matrix to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66677", "l": "(2E,6E)-farnesyl diphosphate + 5,7-dihydroxy-4-methylphthalide => 4-farnesyl-3,5-dihydroxy-6-methylphthalide + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47167", "l": "4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) <=> CO2 + NADH + zymosterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38651", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849435", "l": "PTPN1 dephosphorylates PTK6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2328037", "l": "Fibrillin-1 binds integrins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51595", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + toluene <=> benzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66731", "l": "ATP + H2O + N-acetyl-L-aspartyl-L-glutamate(in) <=> ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47072", "l": "1-eicosanoylglycerol + H2O = eicosanoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49489", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate => 2-oxoglutarate + GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59594", "l": "ADP + beta-alanyl-L-arginine + H(+) + phosphate => ATP + beta-alanine + L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70479", "l": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43483", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944078", "l": "EGR1 binds the PTEN gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035143", "l": "NR1H2,3 binds the APOC4 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66474", "l": "18-episcalar-17(25)-en-19-ol => (2Z,6E,10E,14E)-geranylfarnesol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46794", "l": "2 [Fe(III)-cytochrome b5] + an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 H2O => 2 [Fe(II)-cytochrome b5] + an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13069", "l": "ATP + ethanolamine = ADP + H(+) + phosphoethanolamine"}, {"i": "EC:2.7.1.82", "l": "\"Ethanolamine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63110", "l": "ascofuranol => 16-hydroxy-ilicicolin A epoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197963", "l": "DHFR2 reduces FOLA to DHF (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42987", "l": "(+)-copalyl diphosphate <=> diphosphate + pimara-8(14),15-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30656", "l": "ATP + dUMP => ADP + dUDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353460", "l": "REV1-Pol kappa complex formation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29428", "l": "(R)-carnitine(out) + 4-(trimethylamino)butanoate(in) => (R)-carnitine(in) + 4-(trimethylamino)butanoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73729", "l": "Formation of SL1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5099899", "l": "WNT5A binds FZD4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55161", "l": "coenzyme B + coenzyme M + 2 oxidized [2Fe-2S]-[ferredoxin] => coenzyme M-coenzyme B heterodisulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022365", "l": "GRIA2 gene expression is inhibited by MECP2:SIN3A complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682863", "l": "RNF168 binds DNA DSBs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15905", "l": "3-hydroxycyclohexanone + A = AH2 + cyclohexane-1,3-dione"}, {"i": "EC:1.1.99.26", "l": "\"3-hydroxycyclohexanone dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70481", "l": "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58562", "l": "15alpha-stemmadenine intermediate I + NADPH => 15alpha-stemmadenine intermediate II + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112435", "l": "Formation of Elongin BC complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426156", "l": "SREBP1A,2 binds the PMVK promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53183", "l": "D-erythrose <=> D-erythrulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30757", "l": "ADP + carbamoyl phosphate => ATP + carbamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58470", "l": "2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate => 2 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912372", "l": "Fringe-modified Pre-NOTCH is cleaved by FURIN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27859", "l": "2',3'-cyclic GMP + H2O => 3'-GMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879674", "l": "CD97 binds CD55 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65192", "l": "2 2-oxoglutarate + 2 O2 + preaustinoid A = berkeleytrione + 2 CO2 + H2O + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54818", "l": "[protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+) => L-glutaminyl-[protein] + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37979", "l": "2-methyl-6-phytyl-1,4-benzene-1,4-diol + S-adenosyl-L-methionine = 2,3-dimethyl-6-phytylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50175", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 <=> N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.n2"}]}
{"type": "biolink:MolecularActivity", "ic": "70.502841885620896", "identifiers": [{"i": "GO:0016832", "l": "aldehyde-lyase activity"}, {"i": "EC:4.1.2.-", "l": "\"Aldehyde-lyases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358790", "l": "RNF41 ubiquitinates ERBB3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036243", "l": "succinate-semialdehyde dehydrogenase (NADP+) activity"}, {"i": "RHEA:13213", "l": "H2O + NADP(+) + succinate semialdehyde = 2 H(+) + NADPH + succinate"}, {"i": "EC:1.2.1.79", "l": "\"Succinate-semialdehyde dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64051", "l": "(13Z)-docosenoyl-CoA + sphinganine <=> CoA + H(+) + N-(13Z-docosenoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19197", "l": "adenosine 5'-phosphosulfate + NH4(+) = adenosine 5'-phosphoramidate + 2 H(+) + sulfate"}, {"i": "EC:2.7.7.51", "l": "\"Adenylylsulfate--ammonia adenylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16143", "l": "3''-deamino-3''-oxonicotianamine + H(+) + NADH => 2'-deoxymugineate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69005", "l": "Cdc6 protein is phosphorylated by CDK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43498", "l": "H(+) + keto-D-fructuronate + NADH => L-gulonate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22093", "l": "(3Z)-phycoerythrobilin + oxidized 2[4Fe-4S]-[ferredoxin] => 15,16-dihydrobiliverdin + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371590", "l": "HSP70 binds to HSP40:nascent protein (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-517705", "l": "p-S318,221-HuR binds mRNA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62887", "l": "O2 + 4 semiviriditoxin <=> 2 (M)-viriditoxin + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805546", "l": "Keratin type I binds keratin type II (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54057", "l": "(2E,6E)-farnesyl diphosphate + H2O => (2E,6E)-hedycaryol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34271", "l": "2-nitroimidazole + H2O = 1,3-dihydro-2H-imidazol-2-one + H(+) + nitrite"}, {"i": "EC:3.5.99.9", "l": "\"2-nitroimidazole nitrohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640114", "l": "Misfolded proteins translocate from cilium to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.70", "l": "\"Sortase A\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57873", "l": "(E)-2,4-dihydroxycinnamoyl-CoA => CoA + umbelliferone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57589", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-2-hydroxynaringenin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14524", "l": "(2E)-geraniol + NADP(+) <=> (2E)-geranial + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48001", "l": "1,6-dihydro-beta-NADP + H(+) + O2 => H2O2 + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46215", "l": "H2O + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine <=> 4-amino-5-aminomethyl-2-methylpyrimidine + formate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23788", "l": "acetate + ATP + holo-[citrate lyase ACP] = acetyl-[citrate lyase ACP] + AMP + diphosphate"}, {"i": "EC:6.2.1.22", "l": "\"[Citrate (pro-3S)-lyase] ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42638", "l": "A + H2O + L-alanine + thio-Mo-molybdopterin => AH2 + L-cysteine + Mo-molybdopterin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357831", "l": "CYLD is phosphorylated by IKK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019146", "l": "arabinose-5-phosphate isomerase activity"}, {"i": "KEGG.REACTION:R01530"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12791", "l": "an aldose + H(+) + NADPH => an alditol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016495", "l": "C-X3-C chemokine receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199579", "l": "KIR2DL4 interacting with HLA-G (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374664", "l": "Phosphorylation and activation of Ezrin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21237", "l": "anthranilate + 2 H(+) + NADPH + O2 => 2,3-dihydroxybenzoate + NADP(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20175", "l": "(11E)-tetradecenoyl-CoA + 2 H2O + NAD(+) => H(+) + NADH + O2 + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42752", "l": "pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.177", "l": "\"23S rRNA (pseudouridine(1915)-N(3))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6810724", "l": "PI3 binds the bacterial surface (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45399", "l": "H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22200", "l": "S-adenosyl-L-methionine + trans-aconitate = (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.145", "l": "\"Trans-aconitate 3-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31858", "l": "(S)-2,3-epoxysqualene <=> achilleol B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9609921", "l": "SGTA binds Tail-anchored protein (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12825", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine = [thioredoxin]-dithiol + H(+) + phosphate + sarcosine"}, {"i": "EC:1.21.4.3", "l": "\"Sarcosine reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35634", "l": "cyanidin + UDP-alpha-D-galactose <=> cyanidin 3-O-beta-D-galactoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20263", "l": "CO2 + CoA + olivetol => 3,5,7-trioxododecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54107", "l": "N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64863", "l": "(E)-5-hydroxyferuloyl-CoA + S-adenosyl-L-methionine <=> (E)-sinapoyl-CoA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0016738", "l": "oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor"}, {"i": "EC:1.19.6.-", "l": "\"With dinitrogen as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855155", "l": "I(1,3,4,5,6)P5 transports from the ER lumen to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451310", "l": "Activation of Edited Kainate receptors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694522", "l": "Inner coat assembly and cargo binding (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202489", "l": "Oligomerization of Bcl10 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213246", "l": "Disassociation of CLIP from MHC II (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433578", "l": "phytoceramide + H2O => stearate + phytosphingosine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12837", "l": "ATP + choline = ADP + H(+) + phosphocholine"}, {"i": "EC:2.7.1.32", "l": "\"Choline kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805507", "l": "APAF1 binds AVEN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981713", "l": "C4b binds to cell surface (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38259", "l": "(2R,3S)-beta-methylmalyl-CoA = glyoxylate + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700662", "l": "(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42221", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate => 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18377", "l": "ATP + streptomycin = ADP + H(+) + streptomycin 3''-phosphate"}, {"i": "EC:2.7.1.87", "l": "\"Streptomycin 3''-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34659", "l": "C30 botryococcene + S-adenosyl-L-methionine = 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.284", "l": "\"3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3222128", "l": "NOC2L binds TP53 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30952", "l": "(2E,6E)-farnesyl diphosphate + H2O => alpha-eudesmol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11673", "l": "chorismate + L-glutamine => 4-amino-4-deoxychorismate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34136", "l": "cannabigerolate + O2 => Delta(9)-tetrahydrocannabinolate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16248", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800298", "l": "HGF dimer binds MET (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19648", "l": "a D-threo-aldose + NAD(+) <=> a D-threo-aldono-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72663", "l": "De novo formation of eIF2:GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36105", "l": "O-methyl anthranilate + S-adenosyl-L-homocysteine => anthranilate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617087", "l": "CEBPA binds the promoter of the GFI1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.17"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38103", "l": "L-galactonate = 2-dehydro-3-deoxy-L-galactonate + H2O"}, {"i": "EC:4.2.1.146", "l": "\"L-galactonate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43574", "l": "5-guanidino-2-oxopentanoate + AH2 + NH4(+) => A + D-arginine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37112", "l": "(15Z)-tetracosenoyl-CoA + sphing-4-enine => CoA + H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351936", "l": "Caspase-mediated cleavage of claspin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34723", "l": "15-methylhexadecasphing-4-enine 1-phosphate + H2O = 15-methylhexadecasphing-4-enine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58138", "l": "acetyl-AMP + diphosphate => acetate + ATP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874212", "l": "MBTPS1 (S1P) cleaves CREB3L1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429767", "l": "Passive I- efflux mediated by SMCT1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.-.-", "l": "\"Catalysing the translocation carbohydrates and their derivatives\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004461", "l": "lactose synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676595", "l": "TRAFs bind RANK:RANKL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48709", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.5.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35297", "l": "AMP + H2O + W-molybdopterin cofactor => adenylyl-molybdopterin + H(+) + tungstate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684887", "l": "Activation of CHEK1 at resected DNA DSBs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174757", "l": "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30764", "l": "H2O + L-valine + NAD(+) => 3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093342", "l": "SDC2 multimerises (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34141", "l": "CO2 + Delta(9)-tetrahydrocannabinol => Delta(9)-tetrahydrocannabinolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63328", "l": "2-(9Z-octadecenoyl)-glycerol + ATP = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46233", "l": "(9Z,12Z)-hexadecadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (9Z,12Z,15Z)-hexadecatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50686", "l": "aniline + H(+) + L-glutamate => H2O + N(5)-phenyl-L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668714", "l": "RAC1:GTP binds NOX1 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014293", "l": "RAC2 GDIs block activation of RAC2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17112", "l": "FMNH2 + N-methylnicotinate + O2 <=> (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FMN + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426489", "l": "RISC binds inexactly matching target RNAs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26078", "l": "methanesulfonate + NADH + O2 => formaldehyde + H2O + NAD(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19374", "l": "H2O + L-saccharopine + NADP(+) => 2-oxoglutarate + H(+) + L-lysine + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53612", "l": "CTP + D-ribulose 5-phosphate + H(+) = CDP-D-ribulose + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603419", "l": "Activated NTRK3 binds SRC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607043", "l": "factor VIIIa associates with cell membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36215", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-ethanolamine = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042933", "l": "chrysobactin transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1912394", "l": "NICD1 in complex with RBPJ (CSL) recruits MAML (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692764", "l": "MAPK6 binds CCND3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25685", "l": "L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16610", "l": "AMP + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + adenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21433", "l": "(S)-malate + NAD(+) => H(+) + NADH + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624800", "l": "CDK1 phosphorylates LBR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432424", "l": "JET binds phosphorylated nuclear TIM, facilitating its ubiquitination (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159868", "l": "Furin cleaves pro-factor VII to factor VII (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.1.-", "l": "\"alpha-Amino-acyl-peptide hydrolases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2214351", "l": "PLK1 phosphorylates GORASP1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694521", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18157", "l": "ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate"}, {"i": "EC:2.7.1.40", "l": "\"Pyruvate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088210", "l": "Cytosolic glycoconjugates translocate to the lysosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65308", "l": "an ultra-long-chain di-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxo-ultra-long-chain di-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]"}, {"i": "EC:2.3.1.294", "l": "\"Meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase II\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58395", "l": "4-amino-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8871260", "l": "YAP1 binds TEAD2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30177", "l": "9,9',15-tri-cis-zeta-carotene + 2 plastoquinol-9 => 15-cis-phytoene + 2 plastoquinone-9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688797", "l": "ATXN3 family cleave Ub chains (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44776", "l": "2-demethylmenaquinol-6 + S-adenosyl-L-methionine = H(+) + menaquinol-6 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29291", "l": "(25S)-3-oxocholest-4-en-26-oate + ATP + CoA = (25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate"}, {"i": "EC:6.2.1.42", "l": "\"3-oxocholest-4-en-26-oate--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33712", "l": "4-sulfomuconolactone + H2O => 2 H(+) + maleylacetate + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672011", "l": "p-AMPK:AMP binds the ULK complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047589", "l": "5-aminovalerate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53865", "l": "3alpha,7beta-dihydroxy-12-oxo-5beta-cholan-24-oate + NADP(+) => 7,12-dioxo-lithocholate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371582", "l": "HSBP1 binds HSF1 trimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53929", "l": "a tertiary amine + S-adenosyl-L-methionine => a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39663", "l": "a quinol + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-Glu)(n)"}, {"i": "EC:1.1.98.4", "l": "\"F420H(2):quinone oxidoreductase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033862", "l": "UMP kinase activity"}, {"i": "RHEA:24400", "l": "ATP + UMP = ADP + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55423", "l": "hexadecanoyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15559", "l": "ADP + H(+) + Ni(2+)(in) + phosphate => ATP + H2O + Ni(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199154", "l": "CD200 binds to CD200R (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1671687", "l": "PRLR activation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264615", "l": "Loading of acetylcholine in synaptic vesicles (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31537", "l": "(S)-1-pyrroline-5-carboxylate + CO2 + guanidine + H(+) + H2O + succinate => 2-oxoglutarate + L-arginine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44615", "l": "3-(all-trans-decaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-decaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043027", "l": "cysteine-type endopeptidase inhibitor activity involved in apoptotic process"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44137", "l": "dodecanoyl-CoA + hexadecan-1-ol => CoA + hexadecanyl dodecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36005", "l": "propanal + pyruvate => (S)-4-hydroxy-2-oxohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033450", "l": "GUC codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1299297", "l": "Activation of THIK (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211219", "l": "Translocation of caspase-3 to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51736", "l": "L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981606", "l": "Myoglobin binds oxygen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27791", "l": "2-all-trans-octaprenylphenol + H(+) + NADPH + O2 => 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41040", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + dodecanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-dodecanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944220", "l": "Association of procollagen type XXIII (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944261", "l": "Association of procollagen type XIII (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847880", "l": "CYTH proteins bind ARF1:GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39768", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28622", "l": "uracil(out) => uracil(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50244", "l": "17alpha-hydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxyandrost-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696670", "l": "CHD1L is recruited to GG-NER site (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016515", "l": "interleukin-13 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34580", "l": "2 2-oxoglutarate + 2 O2 + pentalenolactone D => 2 CO2 + H2O + pentalenolactone F + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047077", "l": "Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52771", "l": "2-(glutathion-S-yl)-2-(1H-indol-3-yl)acetonitrile + H2O <=> 2-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59085", "l": "2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose => 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805061", "l": "CK2 binds FACT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018748", "l": "iprodione amidohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35875", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939667", "l": "ITGA5 gene expression is stimulated by RUNX2:CBFB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57559", "l": "(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + zealexin A1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783670", "l": "CRLF1 binds CLCF1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38810", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11420", "l": "NADPH + O2 + senecionine = H2O + NADP(+) + senecionine N-oxide"}, {"i": "EC:1.14.13.101", "l": "\"Senecionine N-oxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102835", "l": "1-18:2-2-16:0-monogalactosyldiacylglycerol desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50479", "l": "anthraniloyl-CoA + L-cysteinyl-[PqsD protein] <=> CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701485", "l": "Active ALK binds JAK3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28183", "l": "(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate => (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14866", "l": "S-adenosyl-L-methionine + tyramine => H(+) + N-methyltyramine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102601", "l": "cytochrome P450 dependent beta-amyrin 16beta-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39625", "l": "(3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+) => 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74065", "l": "GNAT1-GTP binds PDE6 and activates it (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022870", "l": "MOBP gene expression is inhibited by MECP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008307", "l": "structural constituent of muscle"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62622", "l": "[thioredoxin]-disulfide + an alcohol + H2O => [thioredoxin]-dithiol + a hydroperoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29886", "l": "ATP + H2O + L-ornithine(out) <=> ADP + H(+) + L-ornithine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034513", "l": "box H/ACA snoRNA binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050031", "l": "L-pipecolate oxidase activity"}, {"i": "RHEA:11992", "l": "L-pipecolate + O2 = H(+) + H2O2 + L-1-piperideine-6-carboxylate"}, {"i": "EC:1.5.3.7", "l": "\"L-pipecolate oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23929", "l": "H2O + N(8)-acetylspermidine => acetate + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39254", "l": "(2E,11Z)-eicosadienoyl-CoA + H(+) + NADPH <=> (11Z)-eicosenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213208", "l": "Type X collagen associates with collagen type II fibrils (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47853", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O => a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10255", "l": "H(+) + hydrogen sulfide + O-phospho-L-serine <=> L-cysteine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54016", "l": "(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167128", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38594", "l": "devancoaminyl-vancomycin + dTDP-beta-L-4-epi-vancosamine <=> chloroorienticin B + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35086", "l": "diacetylchitobiose-6'-phosphate + H2O <=> acetate + N'-monoacetylchitobiose-6'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617859", "l": "Retinoic acid activates HOXB4 chromatin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033976", "l": "2-haloacid dehalogenase (configuration-inverting) activity"}, {"i": "MetaCyc:3.8.1.10-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58102", "l": "(15Z)-tetracosenoate + glycerol + H(+) => 1-(15Z-tetracosenoyl)-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62751", "l": "H2O + lovastatin <=> (S)-2-methylbutanoate + H(+) + monacolin J"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451033", "l": "(S)-Malate <=> Fumarate + H2O (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684008", "l": "NBN binds KPNA2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39237", "l": "(2E)-triacontenoyl-CoA + H2O => (3R)-hydroxytriacontanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47031", "l": "[DsrC protein]-S-sulfo-L-cysteine/L-cysteine <=> [DsrC protein]-disulfide + H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45237", "l": "(25R)-3beta-hydroxy-5-cholesten-26-al + H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta-hydroxy-5-cholestenoate + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2995334", "l": "COX15 transforms heme O to heme A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28922", "l": "4-aminobutanoate(in) + L-glutamate(out) <=> 4-aminobutanoate(out) + L-glutamate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018487", "l": "vanillate O-demethylase (anaerobic) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3318415", "l": "ATF2 acetylates histone H2B, H4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18409", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17512", "l": "H2O + thiamine <=> 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59312", "l": "D-galactose + O2 = D-galactono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52040", "l": "L-cystine = 2-aminoprop-2-enoate + S-sulfanyl-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.165", "l": "\"Exo-1,4-beta-D-glucosaminidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69116", "l": "Formation of Okazaki fragments (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18935", "l": "(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O => (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51616", "l": "ATP + formate + H(+) = CO2 + dATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11640", "l": "a (2R,3R)-flavan-3-ol + 2 NAD(+) = an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADH"}, {"i": "RHEA:11644", "l": "a (2R,3R)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH"}, {"i": "EC:1.3.1.77", "l": "\"Anthocyanidin reductase ((2R,3R)-flavan-3-ol-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54718", "l": "H(+) + N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51037", "l": "2 2-iminio-3-(indol-3-yl)propanoate + H2O2 => 2 H2O + indole-3-pyruvate imine dimer"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683925", "l": "ULK1 is dephosphorylated (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49070", "l": "(1S)-1,25-dihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin] => 25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32951", "l": "sucrose = trehalulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40266", "l": "(3R)-hydroxyhexadecanedioyl-CoA + NAD(+) <=> 3-oxohexadecanedioyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46397", "l": "2 [Fe(II)-cytochrome b5] + an 11,12-saturated fatty acyl-CoA + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + an (11E)-Delta(11)-fatty acyl-CoA + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071967", "l": "lipopolysaccharide core heptosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15647", "l": "16 ADP + 18 H(+) + H2 + 2 NH4(+) + 4 oxidized [flavodoxin] + 16 phosphate => 16 ATP + 16 H2O + N2 + 4 reduced [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54851", "l": "H(+) + hexan-3-one + NADPH + O2 <=> H2O + NADP(+) + propyl propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0047623", "l": "adenosine-phosphate deaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22299", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate <=> (1R,2R,3R)-prephytoene diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690395", "l": "SOX9 binds the SOX9 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53641", "l": "(2E,6E)-farnesyl diphosphate => (-)-alpha-amorphene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64084", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) = 2,3,6,8,9-pentahydroxy-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracen-1-one + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20817", "l": "3alpha-hydroxyglycyrrhetinate + NADP(+) => 3-oxoglycyrrhetinate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170159", "l": "Translocation of Cdc25 to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41472", "l": "ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oryzalexin D + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.123", "l": "\"Oryzalexin D synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15644", "l": "H(+) + oxaloacetate <=> CO2 + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20494", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine => an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102943", "l": "trans-2,3-dihydro-3-hydroxy-anthranilate isomerase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0010326", "l": "methionine-oxo-acid transaminase activity"}, {"i": "MetaCyc:RXN-2201"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003925", "l": "G protein activity"}, {"i": "EC:3.6.5.2", "l": "\"Small monomeric GTPase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55995", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944227", "l": "Association of procollagen type XXII (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708557", "l": "FBXL17 binds BACH1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45534", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine => H2O + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65293", "l": "2 ATP + butan-2-one + 3 H2O + hydrogencarbonate => 3-oxopentanoate + 2 AMP + 4 H(+) + 4 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341073", "l": "PIAS3 SUMOylates PGR with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062187", "l": "anandamide 8,9 epoxidase activity"}, {"i": "RHEA:53140", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55837", "l": "calcitriol + UDP-alpha-D-glucuronate => calcitriol 25-O-(beta-D-glucuronide) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61265", "l": "H2O + L-alanine + O2 => H2O2 + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45560", "l": "L-isoleucine = D-allo-isoleucine"}, {"i": "EC:5.1.1.21", "l": "\"Isoleucine 2-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48062", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + D-galactose => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50613", "l": "decanal + NADP(+) => (2E)-decenal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46239", "l": "2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55428", "l": "ferruginol + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.60", "l": "\"Ferruginol monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25485", "l": "(2E)-geranyl diphosphate => (1S,4R)-camphene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022465", "l": "MECP2 mutants R106W, D121G, R133H, S134F, T158M and T158A do not bind to 5mC-DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38292", "l": "(S)-malyl-CoA + H2O => (S)-malate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25831", "l": "AH2 + an N-acyl-(4R)-4-hydroxysphinganine + O2 <=> A + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33416", "l": "bornane-2,6-dione + H2O => [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54934", "l": "(2E,9Z)-hexadecadienoyl-[ACP] + H2O => (3R)-hydroxy-(9Z)-hexadecenoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018513", "l": "dibenzothiophene dihydrodiol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190258", "l": "FGFR2c binds to FGF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21389", "l": "H2O + L-2-aminohexano-6-lactam => L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36497", "l": "ADP + alpha-D-glucose 6-phosphate + H(+) => alpha-D-glucose + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928640", "l": "PAKs phosphorylate MLC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102061", "l": "endo-beta-bergamotene synthase activity"}, {"i": "MetaCyc:RXN-10483"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674385", "l": "p-T,Y MAPKs dimerize (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47975", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018647", "l": "phenanthrene 1,2-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.107", "l": "\"Limonene 1,2-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.21", "l": "\"Primary-amine oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49260", "l": "D-galactose(out) + N(pros)-phospho-L-histidyl-[protein] = D-galactose 6-phosphate(in) + L-histidyl-[protein]"}, {"i": "EC:2.7.1.204", "l": "\"Protein-N(pi)-phosphohistidine--D-galactose phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2203516", "l": "Alpha-1-Microglobulin is cleaved (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389481", "l": "Orexin 1 receptor can bind orexin-A neuropeptide (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67082", "l": "a very long-chain fatty acid(out) + ADP + H(+) + phosphate => a very long-chain fatty acid(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-984733", "l": "Kinesin-3 is a dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44605", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O => a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22114", "l": "3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+) => isoxazolin-5-one + O-acetyl-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48956", "l": "[thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18143", "l": "2-hydroxycyclohexan-1-one + H(+) + NADH => NAD(+) + trans-cyclohexane-1,2-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61974", "l": "1-O-(1Z-13-methyltetradecenyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 [Fe(III)-cytochrome b5] + 2 H2O => 1-O-(13-methyltetradecyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156682", "l": "PLK1 phosphorylates NUDC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43315", "l": "ATP + N-(hexanoyl)sphing-4-enine <=> ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15599", "l": "a Fe(III)-siderophore(in) + ADP + H(+) + phosphate => a Fe(III)-siderophore(out) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46432", "l": "(25R)-4beta,26-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta,4beta-dihydroxycholest-5-en-26-al + 2 H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606789", "l": "ARSB hydrolyses DS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102050", "l": "indole-3-acetyl-tyrosine synthetase activity"}, {"i": "MetaCyc:RXN-10432"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648880", "l": "Ferriheme dissociates from p-T-EIF2AK1:2xferriheme dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58460", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine = a monoacyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6804724", "l": "MDM2 ubiquitinates phosphorylated MDM4 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54656", "l": "linalool = (2E)-geraniol"}, {"i": "EC:5.4.4.8", "l": "\"Linalool isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694427", "l": "MIA3 binds procollagen VII (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614605", "l": "Persulfide sulfur is dioxygenated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879362", "l": "AGER binds ERK1/2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58315", "l": "25-substituted-cholesteryl beta-D-glucoside + H2O <=> 25-substituted-cholesterol + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38482", "l": "N(alpha)-methyl-L-histidine + S-adenosyl-L-methionine <=> H(+) + N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49601", "l": "ATP + CoA + octanedioate => AMP + diphosphate + octanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22016", "l": "[glutaredoxin]-dithiol + arsenate + glutathione + 2 H(+) = arsenite + glutathionyl-S-S-[glutaredoxin] + H2O"}, {"i": "EC:1.20.4.1", "l": "\"Arsenate reductase (glutathione/glutaredoxin)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41272", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592398", "l": "Activation of proMMP8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008759", "l": "UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity"}, {"i": "RHEA:25209", "l": "H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine = acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine"}, {"i": "EC:3.5.1.108", "l": "\"UDP-3-O-acyl-N-acetylglucosamine deacetylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031610", "l": "p-S133 CREB1, MEF2D and SRF  bind the ARC gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28001", "l": "H2O + thiamine diphosphate <=> H(+) + phosphate + thiamine phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16159", "l": "2 [Fe(II)-leghemoglobin] + H(+) + NADP(+) => 2 [Fe(III)-leghemoglobin] + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55649", "l": "2-oxoglutarate + O2 + validoxylamine A => CO2 + H(+) + succinate + validoxylamine B"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033746", "l": "histone H3-methyl-arginine-2 demethylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-165680", "l": "Formation of active mTORC1 complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047947", "l": "glutamine N-phenylacetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62501", "l": "holo-[peptidyl-carrier protein] + L-arginyl-AMP => AMP + H(+) + L-arginyl-[peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9035484", "l": "CysS248-MPST:TXN2 dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44166", "l": "adenine + D-ribose 5-triphosphate => ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17204", "l": "2-dehydro-3-deoxy-L-arabinonate <=> 2,5-dioxopentanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "68.661248405853954", "identifiers": [{"i": "GO:0016866", "l": "intramolecular transferase activity"}, {"i": "EC:5.4.-.-", "l": "\"Intramolecular transferases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19164", "l": "2 2-aminophenol + O2 <=> 2 6-iminocyclohexa-2,4-dienone + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017032", "l": "amino acid:potassium symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66113", "l": "2-oxobutanoate + L-tyrosine => (2S)-2-aminobutanoate + 3-(4-hydroxyphenyl)pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.207", "l": "\"Mannosyl-oligosaccharide alpha-1,3-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805620", "l": "KAT6A and PML bind TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008499", "l": "UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity"}, {"i": "REACT:R-HSA-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Homo sapiens)"}, {"i": "REACT:R-HSA-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4837364", "l": "Secretion of SOD3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052772", "l": "brefeldin A esterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50074", "l": "ADP + H(+) + phosphate + tauroursodeoxycholate(out) => ATP + H2O + tauroursodeoxycholate(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001785", "l": "prostaglandin J receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8963915", "l": "1,25(OH)2D binds VDR (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62202", "l": "2 [Fe(II)cytochrome c] + acetaldehyde + 2 H(+) => 2 [Fe(III)cytochrome c] + ethanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381446", "l": "Thrombin proteolyzes IGF:IGFBP3:ALS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59761", "l": "apigenin + UDP-alpha-D-glucose => apigenin 7-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9688832", "l": "MLKL binds PDCD6IP and SDCBP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871265", "l": "YAP1 binds TEAD4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57887", "l": "diphosphate + H2O + Na(+)(in) <=> H(+) + Na(+)(out) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17100", "l": "3-phenylpyruvate <=> enol-phenylpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38561", "l": "(R)-2-hydroxytetracosanoate + 2 [Fe(III)-cytochrome b5] + H2O => 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + tetracosanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018591", "l": "methyl tertiary butyl ether 3-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58724", "l": "adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45285", "l": "eicosanoyl-CoA + sphing-4-enine => CoA + H(+) + N-eicosanoyl-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399952", "l": "Phosphorylation of LIMK-1 by PAK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22767", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44730", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199046", "l": "Ligands bind L-selectin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156930", "l": "GTP-binding activates eEF2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16377", "l": "(3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin] = biliverdin IXalpha + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.3.7.4", "l": "\"Phytochromobilin:ferredoxin oxidoreductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050137", "l": "NADPH peroxidase activity"}, {"i": "RHEA:15173", "l": "H(+) + H2O2 + NADPH = 2 H2O + NADP(+)"}, {"i": "EC:1.11.1.2", "l": "\"NADPH peroxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.102"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9611852", "l": "ADRB3 bind ADR,NAd (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24447", "l": "GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[(1->4)-alpha-L-Fuc]-beta-D-GlcNAc}-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130627", "l": "MHC class II antigen internalization (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33065", "l": "NADH + 2 oxidized [2Fe-2S]-[putidaredoxin] => H(+) + NAD(+) + 2 reduced [2Fe-2S]-[putidaredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61114", "l": "(2R,3R)-dihydroquercetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2R,3R)-dihydrokaempferol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806957", "l": "MET receptor dimerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9611839", "l": "β3-agonists bind ADRB3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48150", "l": "ganglioside GD1b(d18:1(4E)/18:0) + N-acetylneuraminate => ganglioside GT1b (d18:1(4E)/18:0) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12210", "l": "4-methylumbelliferone + acetate + H(+) => 4-methylumbelliferyl acetate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419461", "l": "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34831", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate = N-acyl-15-methylhexadecasphing-4-enine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55214", "l": "formyl-CoA + pentadecanal => (2R)-hydroxyhexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205118", "l": "TRAF6 polyubiquitinates NRIF (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042907", "l": "xanthine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004397", "l": "histidine ammonia-lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14689", "l": "4-chlorophenylacetate + NADH + O2 = 3,4-dihydroxyphenylacetate + chloride + NAD(+)"}, {"i": "EC:1.14.12.9", "l": "\"4-chlorophenylacetate 3,4-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977363", "l": "Factor H binds to C3bBb (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0042876", "l": "aldarate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28807", "l": "glutathione + H2O = L-cysteinylglycine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8981926", "l": "RAC1 and CDC42 activate PAK3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8935732", "l": "RUNX1 binds SIN3A,(SIN3B) co-repressor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983300", "l": "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-622310", "l": "Activated NOD1 oligomerizes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34369", "l": "acrylate + NH4(+) => acrylamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54359", "l": "3-methyl-2-oxobutanoate + H(+) <=> 2-methylpropanal + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52584", "l": "chenodeoxycholoyl-CoA + NAD(+) = 7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44016", "l": "2,6,10,14-tetramethylpentadecanal + H2O + NAD(+) = 2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15803", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33438", "l": "24-methylene-5alpha-cholest-8-en-3beta-ol <=> episterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64455", "l": "L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54773", "l": "ATP + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide => 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783492", "l": "TRMT6:TRMT61A methylate adenosine yielding 1-methyladenosine at nucleotide 58 of tRNA(Met) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44818", "l": "2-demethylmenaquinol-12 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36156", "l": "AH2 + Co(II)-factor III + S-adenosyl-L-methionine => A + Co-precorrin-4 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004409", "l": "homoaconitate hydratase activity"}, {"i": "RHEA:15485", "l": "(1R,2S)-homoisocitrate = cis-homoaconitate + H2O"}, {"i": "EC:4.2.1.36", "l": "\"Homoaconitate hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48714", "l": "2 Fe(3+) + 2 H2O => 2 Fe(2+) + 2 H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019143", "l": "3-deoxy-manno-octulosonate-8-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47756", "l": "guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23133", "l": "3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] => 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1006169", "l": "Factor H binds host cell surface markers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675473", "l": "SH2B binds JAK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61383", "l": "2,4-dinitrophenyl-S-glutathione(in) + ATP + H2O <=> 2,4-dinitrophenyl-S-glutathione(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381668", "l": "cAMP activates EPAC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651828", "l": "PARG dePARylates PARP1,PARP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671862", "l": "JAK2 Phosphorylates IRS in Response to Leptin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-481044", "l": "Surface deployment of platelet alpha granule membrane components (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26348", "l": "L-galactonate + NADP(+) <=> aldehydo-D-galacturonate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50382", "l": "1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA => 3 H(+) + 3 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28531", "l": "H2O + XMP => phosphate + xanthosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983147", "l": "Release of E3 from polyubiquitinated substrate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605724", "l": "Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48267", "l": "H2O + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] <=> H(+) + S-sulfanyl-L-cysteinyl-[SoxY protein] + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59570", "l": "ADP + H(+) + L-homocarnosine + phosphate => 4-aminobutanoate + ATP + L-histidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705738", "l": "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29342", "l": "(S)-malate(in) + 2 H(+)(in) <=> (S)-malate(out) + 2 H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29596", "l": "CoA + NADP(+) + sulfoacetaldehyde => H(+) + NADPH + sulfoacetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55386", "l": "6 diphosphate + tetra-trans,hexa-cis-undecaprenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390641", "l": "ADRA1A,B,D bind ADR,NAd (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36217", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848726", "l": "PTK6 phosphorylates BCAR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9612509", "l": "SGK phosphorylates SRF (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38945", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47423", "l": "A + glutaryl-CoA <=> (2E)-glutaconyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11649", "l": "(-)-menthol + H(+) + NADPH + O2 => 1,4-menthane-3,8-diol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25833", "l": "1D-chiro-inositol + NAD(+) => H(+) + NADH + scyllo-inosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26554", "l": "angiotensin II + H2O = angiotensin-(1-7) + L-phenylalanine"}, {"i": "EC:3.4.17.23", "l": "\"Angiotensin-converting enzyme 2\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61021", "l": "acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA => 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098601", "l": "selenomethionine adenosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981093", "l": "IL12 bound to IL12R internalises (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41515", "l": "L-ornithine + NADH + O2 <=> H2O + N(5)-hydroxy-L-ornithine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60367", "l": "H(+)(out) + myo-inositol(out) <=> H(+)(in) + myo-inositol(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844438", "l": "NLRP1 oligomerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112437", "l": "Formation of NELF complex  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237119", "l": "Acireductone is oxidized to MOB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2032770", "l": "Translocation of YAP1 to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683325", "l": "Defective ABCD4:LMBRD1 does not transport Cbl from lysosomal lumen to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40524", "l": "a quinone + succinate => a quinol + fumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624951", "l": "TNPO1 binds KIF17 dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28560", "l": "D-fructose + phosphate => D-fructose 6-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28682", "l": "3-demethylubiquinol-8 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46901", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) => a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) (E. coli)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37986", "l": "gamma-tocopherol <=> 2,3-dimethyl-6-phytylbenzene-1,4-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47639", "l": "H2O + L-arginine + NADP(+) <=> 5-guanidino-2-oxopentanoate + H(+) + NADPH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854981", "l": "SHC1 in the RET complex is phosphorylated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71303", "l": "RPE dimers isomerise RU5P to XY5P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34439", "l": "2,3-didehydroadipyl-CoA + acetyl-CoA = 3-oxo-5,6-didehydrosuberyl-CoA + CoA"}, {"i": "EC:2.3.1.223", "l": "\"3-oxo-5,6-didehydrosuberyl-CoA thiolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848864", "l": "PTK6 binds ARAP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64402", "l": "an L-amino acid tripeptide(in) + H(+)(in) => an L-amino acid tripeptide(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23336", "l": "2 H(+) + H2O2 + 2 iodide = diiodine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14843", "l": "ent-copalyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17872", "l": "5,6,7,8-tetrahydropteridine + NAD(+) <=> 6,7-dihydropteridine + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19189", "l": "[dihydrolipoyllysine-residue acetyltransferase]-(R)-N(6)-lipoyl-L-lysine + H(+) + pyruvate = [dihydrolipoyllysine-residue acetyltransferase]-(R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysine + CO2"}, {"i": "EC:1.2.4.1", "l": "\"Pyruvate dehydrogenase (acetyl-transferring)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8963915", "l": "1,25(OH)2D binds VDR (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800490", "l": "ATM phosphorylates PIDD1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2995330", "l": "COX10 transforms heme to heme O (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675198", "l": "Activated MAPKs phosphorylate BRAF (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11523", "l": "(-)-menthol + UDP-alpha-D-glucose <=> (-)-menthyl beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56288", "l": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.74", "l": "\"Albendazole monooxygenase (hydroxylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57955", "l": "H(+) + NADH + O2 + phenol <=> catechol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-141437", "l": "Formation of the MCC complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48497", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + UDP-alpha-D-galactose => 1-(9Z-octadecenoyl)-2-hexadecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23675", "l": "a quinone + L-quinate <=> 3-dehydroquinate + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71445", "l": "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052825", "l": "inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity"}, {"i": "REACT:R-HSA-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30299", "l": "2-oxoglutarate + a methylated nucleobase within DNA + O2 = a nucleobase within DNA + CO2 + formaldehyde + succinate"}, {"i": "EC:1.14.11.33", "l": "\"DNA oxidative demethylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56577", "l": "globoside Gb3Cer + UDP-N-acetyl-alpha-D-galactosamine => globoside Gb4Cer + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48679", "l": "6-trans-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-6-trans-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35635", "l": "an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + UDP-alpha-D-glucose = an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucoside + H(+) + UDP"}, {"i": "EC:2.4.1.296", "l": "\"Anthocyanidin 3-O-coumaroylrutinoside 5-O-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56715", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] <=> H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39210", "l": "3-oxohexacosanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxyhexacosanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10093", "l": "a 2'-deoxyribonucleoside 3'-phosphate + H2O => a 2'-deoxyribonucleoside + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47957", "l": "3-maleylpyruvate + H2O => H(+) + maleate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163402", "l": "diacylglycerol + H2O -> 2-acylglycerol + fatty acid (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672978", "l": "RAF phosphorylates MAP2K dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-199456", "l": "PTEN dephosphorylates PIP3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65445", "l": "butanoyl-CoA + hexan-1-ol => CoA + hexyl butanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64991", "l": "CoA + H2O <=> adenosine 3',5'-bisphosphate + D-pantetheine 4'-phosphate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802915", "l": "Moderate kinase activity BRAF mutants bind RAS:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48710", "l": "a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47276", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018602", "l": "2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047585", "l": "4-pyridoxolactonase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13398", "l": "6-oxohexanoate + H2O + NADP(+) => 2 H(+) + hexanedioate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209167", "l": "Phosphorylated REL is cleaved by and dissociates from DREDD in the PGN:PGRP-LC oligomer receptor 'signalling complex' (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901604", "l": "dethiobiotin transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156678", "l": "Activation of Cdc25C (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395764", "l": "atREs binds to nascent CM (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56888", "l": "UDP-4-dehydro-6-deoxy-alpha-D-glucose = UDP-4-dehydro-beta-L-rhamnose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66227", "l": "asc-C9-CoA + O2 <=> asc-DeltaC9-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001068", "l": "arabinoxylan binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047223", "l": "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity"}, {"i": "MetaCyc:2.4.1.146-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626988", "l": "TNF-alpha:TNFR1 binds NSMAF (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19145", "l": "D-glucose 6-sulfate + H2O = D-glucose + H(+) + sulfate"}, {"i": "EC:3.1.6.3", "l": "\"Glycosulfatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43173", "l": "guanosine(1575) in yeast 18S rRNA + S-adenosyl-L-methionine => N(7)-methylguanosine(1575) in yeast 18S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013435", "l": "RHOD auto-activates (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52514", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+) => a quinone + trans-4-hydroxy-L-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59531", "l": "hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein] <=> CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53150", "l": "H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10422", "l": "L-alanine + sulfoacetaldehyde => pyruvate + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "78.047734625335977", "identifiers": [{"i": "GO:0016872", "l": "intramolecular lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3076905", "l": "Extracellular BTD hydrolyses BCTN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39799", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+) = 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20231", "l": "2,3-dihydroxybenzoyl-5'-AMP + diphosphate => 2,3-dihydroxybenzoate + ATP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54112", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + selina-4(15),7(11)-diene"}, {"i": "EC:4.2.3.181", "l": "\"Selina-4(15),7(11)-diene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19978", "l": "3'-phosphoadenylyl sulfate + L-tyrosine methyl ester => adenosine 3',5'-bisphosphate + H(+) + L-tyrosine methyl ester 4-sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.194", "l": "\"Ginsenosidase type IV\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34031", "l": "2'-N-acetylparomamine + H2O = acetate + paromamine"}, {"i": "EC:3.5.1.112", "l": "\"2'-N-acetylparomamine deacetylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36896", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + AH2 + O2 => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74947", "l": "p-MII:SAG dissociates to p-RHO and SAG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57675", "l": "(+)-5-epi-aristolochene + O2 + reduced [NADPH--hemoprotein reductase] <=> 2beta-hydroxy-5-epi-aristolochene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050643", "l": "10-deacetylbaccatin III 10-O-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33848", "l": "H2O + N-tetracosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + tetracosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37050", "l": "H(+)(out) + L-histidine(out) <=> H(+)(in) + L-histidine(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090613", "l": "5'-deoxyadenosine deaminase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050591", "l": "quinine 3-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72185", "l": "mRNA polyadenylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17433", "l": "A + choline = AH2 + betaine aldehyde"}, {"i": "EC:1.1.99.1", "l": "\"Choline dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30943", "l": "FAD + H(+) + octanoyl-CoA = (2E)-octenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46187", "l": "ATP + CoA + isovalerate <=> 3-methylbutanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31505", "l": "4,6-Me(COOH)C-beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphate => beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39795", "l": "7beta-hydroxycholesterol(in) + ATP + H2O = 7beta-hydroxycholesterol(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57397", "l": "(S)-S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine => 3-O-acetylpapaveroxine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810843", "l": "Envoplakin binds periplakin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16061", "l": "H2O + sn-glycerol 3-phosphocholine = choline + H(+) + sn-glycerol 3-phosphate"}, {"i": "EC:3.1.4.2", "l": "\"Glycerophosphocholine phosphodiesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64944", "l": "dCTP + 2 H2O = dCMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23191", "l": "NAD(+) + propane-1,3-diol <=> 3-hydroxypropanal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109862", "l": "MAP2K2 phosphorylates MAPK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53384", "l": "5,10-methylenetetrahydromethanopterin + NAD(+) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53191", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine + H2O <=> 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751040", "l": "PKC phosphorylates G alpha (z) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868118", "l": "MAPK12 phosphorylates PTPN3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10047", "l": "cyclohexanol + NAD(+) <=> cyclohexanone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19894", "l": "4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP => 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51002", "l": "[fructose-bisphosphate aldolase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine => [fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214871", "l": "Phosphorylated CACT is degraded in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0099511", "l": "voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018594", "l": "MECP2 binds LBR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626699", "l": "MARK4 binds ODF2 in the centriole (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8955844", "l": "RBKS phosphorylates ribose to R5P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790994", "l": "DIMT1 dimethylates adenosine-1850,1851 of 18S rRNA yielding 6-dimethyladenosine-1850,1851 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852337", "l": "GTSE1 binds TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62779", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n3", "l": "\"ISG15--protein ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8863494", "l": "ASICs bind STOML3, (STOM) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938815", "l": "RNF152 polyubiquitinates RRAGA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51583", "l": "a fatty acid(out) + ATP(in) + CoA(in) + H(+)(out) <=> a fatty acyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53573", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806408", "l": "TP53 binds the PMS2 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24372", "l": "H2O + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] = H(+) + N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine"}, {"i": "EC:3.1.4.45", "l": "\"N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086084", "l": "cell adhesive protein binding involved in Purkinje myocyte-ventricular cardiac muscle cell communication"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42022", "l": "H(+) + NADH + pregn-4-ene-3,11,20,21-tetraone => 11-dehydrocorticosterone + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51020", "l": "2 [Fe(III)cytochrome c] + a primary alcohol = 2 [Fe(II)cytochrome c] + an aldehyde + 2 H(+)"}, {"i": "EC:1.1.2.8", "l": "\"Alcohol dehydrogenase (cytochrome c)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12613", "l": "2 glutathione + L-cystine = glutathione disulfide + 2 L-cysteine"}, {"i": "EC:1.8.4.4", "l": "\"Glutathione--cystine transhydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54232", "l": "1,2-dioctanoyl-sn-glycerol + CDP-choline = 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65104", "l": "aculene D + L-prolyl-[peptidyl-carrier protein] = aculene B + holo-[peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806831", "l": "CYB5Rs reduce MetHb to HbA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139909", "l": "Translocation of BMF to mitochondria (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27562", "l": "(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate <=> all-trans-hexaprenyl diphosphate + 3 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420128", "l": "SRC-1 phosphorylates SHB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63589", "l": "prunetin + UDP-alpha-D-glucuronate => prunetin-4'-O-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016920", "l": "pyroglutamyl-peptidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004974", "l": "leukotriene receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351208", "l": "Spermidine  => N-acetylated spermidine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202947", "l": "Caspase mediated cleavage of APC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65955", "l": "2 a quinone + H(+) + NADH <=> 2 a 1,4-benzosemiquinone + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220988", "l": "NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25939", "l": "8-methylquinoline + A + H2O <=> 8-methylquinolin-2(1H)-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63373", "l": "an acyl-CoA + L-cysteinyl-[protein] => an S-acyl-L-cysteinyl-[protein] + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200396", "l": "Creatine transport across the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0050497", "l": "alkylthioltransferase activity"}, {"i": "EC:2.8.4.-", "l": "\"Transferring alkylthio groups\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9699578", "l": "Active FLT3 phosphorylates CDKN1B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45129", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683735", "l": "CHEK2 is recruited to DNA DSBs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49730", "l": "CO2 + 2 H2O + NADP(+) + violacein => 2 H(+) + NADPH + 2 O2 + protoviolaceinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163820", "l": "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59875", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610442", "l": "Tail-anchored protein:SGTA dimer binds BAG6:GET4:UBL4A and ASNA1:ATP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60705", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-2,3-cyclic phosphate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52733", "l": "3'-phosphoadenylyl sulfate + an 11-hydroxyjasmonate => adenosine 3',5'-bisphosphate + an 11-sulfojasmonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14386", "l": "dolichyl diphosphate + H2O => dolichyl phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28551", "l": "acetyl-CoA + anthranilate => CoA + N-acetylanthranilate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61575", "l": "(11Z,14Z)-eicosadienoate + O2 <=> (15S)-hydroperoxy-(11Z,13E)-eicosadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36920", "l": "(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5665871", "l": "ADRM1 binds 26S proteasome (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33441", "l": "glyoxylate + H(+) + H2O2 => glyoxal + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102297", "l": "selenate adenylyltransferase activity"}, {"i": "MetaCyc:RXN-12720"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2301205", "l": "SETD8 monomethylates histone H4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806610", "l": "Keratin filament formation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3222093", "l": "BRD7 binds TP53 and EP300 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35838", "l": "2'-dehydrokanamycin A + H(+) + NADPH <=> kanamycin A + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18947", "l": "CO2 + succinate + trans-4-hydroxy-L-prolyl-[collagen] => 2-oxoglutarate + L-prolyl-[collagen] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47870", "l": "(9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+) => di-(9Z)-octadecenoylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45814", "l": "a very-long-chain (2E)-enoyl-CoA + H2O => a very-long-chain (3R)-3-hydroxyacyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804099", "l": "HMGB1 binds LTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803890", "l": "SFN dimerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358790", "l": "RNF41 ubiquitinates ERBB3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216048", "l": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13242", "l": "ATP + L-fucose => ADP + beta-L-fucose 1-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645535", "l": "ALPK1 phosphorylates TIFA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24759", "l": "H(+) + NADPH + O2 + pheophorbide a <=> NADP(+) + red chlorophyll catabolite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50355", "l": "3 (R)-methylmalonyl-CoA + 9 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 6 NADPH <=> 3 CO2 + 3 CoA + 3 H2O + 6 NADP(+) + trimethylated-mycocerosoyl-[mycocerosate synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24864", "l": "pelargonidin 3-O-rutinoside + UDP-alpha-D-glucose <=> H(+) + pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55674", "l": "4-O-([2-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP => 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983153", "l": "E1 mediated ubiquitin activation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-165195", "l": "GTP loading by Rheb (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909732", "l": "Phosphorylation of STAT2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446364", "l": "Migfilin interacts with VASP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373867", "l": "BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50606", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein] => acetyl-CoA + N-terminal L-methionyl-[transmembrane protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60675", "l": "NAD(+) + nerol <=> H(+) + NADH + neral"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58871", "l": "24-methylidenelophenol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013158", "l": "CDC42 GDIs block activation of CDC42 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28004", "l": "D-glyceraldehyde 3-phosphate + dihydroxyacetone => beta-D-fructose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30142", "l": "H2O + octadecanoyl-CoA <=> CoA + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44144", "l": "acetyl-CoA + L-methionine = CoA + H(+) + N(alpha)-acetyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140702", "l": "cyclic GMP-AMP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48557", "l": "4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) => 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59074", "l": "5'-deoxyadenosine + A + cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => AH2 + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5483238", "l": "Hh processing variants are ubiquitinated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667809", "l": "KCNMA1:KCNMB1 transports potassium ions from the cytosol to the extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27758", "l": "(6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + CO2 + NADH + NH4(+)"}, {"i": "EC:1.4.1.27", "l": "\"Glycine cleavage system\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49604", "l": "2-glutathionyl-2-methylbut-3-en-1-ol + NAD(+) = 2-glutathionyl-2-methylbut-3-enal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391913", "l": "FPR2 binds FPR2 ligands (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31497", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37694", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA <=> 1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27355", "l": "H(+) + rebeccamycin + S-adenosyl-L-homocysteine => 4'-demethylrebeccamycin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936985", "l": "Activated TLR4:TICAM1 recruits TRAF6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28745", "l": "nitrate(out) + nitrite(in) => nitrate(in) + nitrite(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420591", "l": "Nectin-2:Nectin 3 trans heterodimer interaction (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951727", "l": "cAMP binds PKA tetramer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11846", "l": "CoA + pyruvate => acetyl-CoA + formate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050334", "l": "thiaminase activity"}, {"i": "MetaCyc:THIAMINASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49365", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + H(+) => 17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21418", "l": "dihydroxyacetone phosphate + H(+) + NADPH => NADP(+) + sn-glycerol 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374664", "l": "Phosphorylation and activation of Ezrin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043883", "l": "malolactic enzyme activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24863", "l": "H(+) + pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP => pelargonidin 3-O-rutinoside + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373875", "l": "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730904", "l": "Auto-ubiquitination of TRAF6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65572", "l": "(-)-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] = (-)-4'-desmethyl-deoxypodophyllotoxin + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708466", "l": "BACH1 translocates from the nucleoplasm to the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50946", "l": "(E)-cinnamate + H(+) + NADH => 3-phenylpropanoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912627", "l": "CBL ubiquitinates PI3K (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944262", "l": "Association of procollagen type X (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794356", "l": "BEGAIN binds DLG2,DLG3,DLG4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66857", "l": "(2E)-geranyl diphosphate + 3 isopentenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15381", "l": "O2 + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO"}, {"i": "EC:1.13.11.24", "l": "\"Quercetin 2,3-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5663050", "l": "DHI and DHICA polymerise forming eumelanin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109813", "l": "GRB2-1 binds SOS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694583", "l": "ABHD4 hydrolyses NAPE (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40313", "l": "(2E)-hexenoyl-CoA + H2O2 => hexanoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43290", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + phosphate => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39735", "l": "3-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 3,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43084", "l": "cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0071077", "l": "adenosine 3',5'-bisphosphate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61768", "l": "rebaudioside A + UDP-alpha-D-glucose = H(+) + rebaudioside D + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18872", "l": "ATP + L-xylulose <=> ADP + H(+) + L-xylulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54329", "l": "2 H(+) + hexadecanoyl-[ACP] + 2 NADPH => hexadecan-1-ol + holo-[ACP] + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9661419", "l": "ALB binds extracellular heme (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624668", "l": "CEBPA binds CDKN1A (p21) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66660", "l": "ATP + beta-D-glucosylceramide(in) + H2O = ADP + beta-D-glucosylceramide(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49050", "l": "1alpha,25-dihydroxyvitamin D2 + H2O + 2 oxidized [adrenodoxin] => 25-hydroxyvitamin D2 + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709852", "l": "MAVS:TOMM70 recruits HSP90:TBK1:IRF3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15603", "l": "(E)-cinnamate + (R)-3-phenyllactoyl-CoA => (E)-cinnamoyl-CoA + (R)-3-phenyllactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15423", "l": "a long-chain fatty acyl-CoA + AMP + diphosphate => a long-chain fatty acid + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48563", "l": "H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate <=> D-ribose 5-phosphate + N(6)-dimethylallyladenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.37"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2974737", "l": "NOTCH2 binds MDK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61716", "l": "ATP + D-galactofuranose(out) + H2O = ADP + D-galactofuranose(in) + H(+) + phosphate"}, {"i": "EC:7.5.2.9", "l": "\"ABC-type D-galactofuranose transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27429", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate"}, {"i": "RHEA:36239", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate"}, {"i": "EC:3.1.3.4", "l": "\"Phosphatidate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1253325", "l": "ERBB4s80 binds TAB2:NCOR1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805792", "l": "p-S291-PHF20 translocates to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.225", "l": "\"F-actin monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013361", "l": "NEXT3 is cleaved to produce NICD3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73757", "l": "Binding of RRN3 to RNA Polymerase I (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168897", "l": "LRP1 (CD91) binds Hemopexin:heme (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851011", "l": "TRIM27 polyubiquitinates PTEN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174963", "l": "NAT1 acetylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59444", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene + A = 1,1'-dihydroxy-3,4-didehydro-1,2-dihydrolycopene + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098623", "l": "selenite reductase activity"}, {"i": "REACT:R-HSA-2408558", "l": "SeO3(2-) is reduced to H2Se by TXNRD1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45985", "l": "3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH + O2 => 9alpha-hydroxy-3-oxochola-1,4-dien-22-oyl-CoA + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008073", "l": "ornithine decarboxylase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2545253", "l": "Deacetylation of cohesin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374298", "l": "Opioid receptors bind opioid peptides (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106314", "l": "nitrite reductase NADPH activity"}, {"i": "RHEA:24632", "l": "2 H2O + 3 NADP(+) + NH4(+) = 5 H(+) + 3 NADPH + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810643", "l": "EPPIN protein complex binds bacteria (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6793666", "l": "MDM2 translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51185", "l": "1-octadecanoyl-sn-glycero-3-phosphoserine + H2O => H(+) + octadecanoate + sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20914", "l": "diphosphate + taxa-4,11-diene => (2E,6E,10E)-geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050252", "l": "retinol O-fatty-acyltransferase activity"}, {"i": "REACT:R-HSA-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372819", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39724", "l": "a 1,2-diacyl-sn-glycerol(in) => a 1,2-diacyl-sn-glycerol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49529", "l": "(ethylene terephthalate)(n) + H2O => (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848436", "l": "PTK6 phosphorylates CDKN1B (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0008452", "l": "RNA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43769", "l": "an alkylamine + L-glutaminyl-[protein] => N(5)-alkyl-L-glutaminyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83788", "l": "Binding of TFIIIC to Type 2 promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16861", "l": "(S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate"}, {"i": "EC:2.6.1.62", "l": "\"Adenosylmethionine--8-amino-7-oxononanoate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937792", "l": "RUNX3 binds SRC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56545", "l": "H2O + N-hexadecanoyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868230", "l": "SNX9 recruits components of the actin polymerizing machinery (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009385", "l": "N-acylmannosamine-6-phosphate 2-epimerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.99.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937613", "l": "CRHBP binds CRH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58784", "l": "2-oxoglutarate + a 5'-methyltriphosphate-guanosine-ribonucleotide-snRNA + O2 = a 5'-triphospho-guanosine-ribonucleotide-snRNA + CO2 + formaldehyde + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35275", "l": "3-hydroxyoctadecanoyl-CoA + NAD(+) = 3-oxooctadecanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373732", "l": "Nephrin trans-homophilic interaction (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19971", "l": "H(+) + H2O + nitrite => hydroxylamine + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051992", "l": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"}, {"i": "MetaCyc:PHOSNACMURPENTATRANS-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482772", "l": "Release of platelet cytosolic components (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40551", "l": "demethylphylloquinol + S-adenosyl-L-methionine = H(+) + phylloquinol + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.329", "l": "\"Demethylphylloquinol methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61850", "l": "cholesteryl 3-beta-D-glucoside + H(+) + UDP => cholesterol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066785", "l": "Retranslocation of DHA back to ER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57682", "l": "a flavone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => a flavanone + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35375", "l": "(beta-L-Ara4N)2-(Kdo)2-lipid A(in) + ATP + H2O = (beta-L-Ara4N)2-(Kdo)2-lipid A(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009384", "l": "N-acylmannosamine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37266", "l": "ATP + H2O + L-alanyl-L-aspartate(out) <=> ADP + H(+) + L-alanyl-L-aspartate(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18678", "l": "[Fe(III)-cytochrome b5] + L-ascorbate => [Fe(II)-cytochrome b5] + H(+) + monodehydro-L-ascorbate radical"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649726", "l": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11443", "l": "2,3,5,6-tetrachlorophenol + NADPH + O2 <=> 2,3,5,6-tetrachlorohydroquinone + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22360", "l": "D-glutamate = 5-oxo-D-proline + H2O"}, {"i": "EC:4.2.1.48", "l": "\"D-glutamate cyclase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63044", "l": "H2O + mevastatin = H(+) + mevinic carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50375", "l": "an N-acylsphingoid base 1-phosphate(in) <=> an N-acylsphingoid base 1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45398", "l": "(9Z)-octadecenoate + H(+) + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49686", "l": "benzene-1,2,4-triol + H2O + NAD(+) => H(+) + NADH + O2 + resorcinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44671", "l": "4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol <=> 4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1299338", "l": "Activation of TRESK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12870", "l": "(2E)-geranyl diphosphate => (4S)-limonene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45371", "l": "H2O + N-(9Z-octadecenoyl)-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + (9Z)-octadecenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29273", "l": "a menaquinone + H2O + trimethylamine => a menaquinol + H(+) + trimethylamine N-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23647", "l": "lithocholate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + hyodeoxycholate + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17046", "l": "1,2-bis-(3,4-dimethoxyphenyl)propane-1,3-diol + H2O2 => 1-(3,4-dimethoxyphenyl)ethane-1,2-diol + 3,4-dimethoxybenzaldehyde + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2429719", "l": "MCPH1 sequesters condensin II (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654422", "l": "Activated FGFR4 binds FRS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39174", "l": "3-oxoeicosanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxyeicosanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51278", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23682", "l": "a ribonucleoside 5'-diphosphate + H(+) + phosphate => a ribonucleoside 5'-triphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35486", "l": "5alpha-cholest-7-en-3-one + S-adenosyl-L-methionine <=> 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54860", "l": "(2E)-geranial + H(+) + NADPH + O2 = (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13059", "l": "an N-acylneuraminate + phosphate => an N-acylneuraminate 9-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031760", "l": "Edg-7 lysophosphatidic acid receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26314", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate => dihydroxyacetone phosphate + L-aspartate 4-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24263", "l": "(3E)-2-oxohex-3-enedioate + H(+) <=> 2-oxopent-4-enoate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858475", "l": "TNFSF9 binds TNFRSF9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856223", "l": "B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17789", "l": "(S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine = (S)-reticuline + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.116", "l": "\"3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58212", "l": "ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] = dihydroserpentine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16809", "l": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate"}, {"i": "EC:4.1.3.30", "l": "\"Methylisocitrate lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5661217", "l": "MT1A binds zinc (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48854", "l": "13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57437", "l": "guaethol + O2 + reduced [NADH--hemoprotein reductase] => acetaldehyde + catechol + H(+) + H2O + oxidized [NADH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985485", "l": "RUNX2 and RB1 bind the BGLAP gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1362416", "l": "Frataxin binds iron (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28220", "l": "H2O + hypochlorous acid => chloride + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39253", "l": "(11Z)-eicosenoyl-CoA + NADP(+) => (2E,11Z)-eicosadienoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617833", "l": "SOD2 gene expression is stimulated by FOXO4, FOXO3 and FOXO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390929", "l": "HTR1 and 5A receptors can bind serotonin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47184", "l": "5alpha-cholesta-7,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + cholesta-5,7,24-trien-3beta-ol + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015044", "l": "rubredoxin-NAD+ reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25828", "l": "AH2 + an N-acyl-(4R)-4-hydroxysphinganine + O2 = A + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54464", "l": "1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047434", "l": "indolepyruvate decarboxylase activity"}, {"i": "MetaCyc:4.1.1.74-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868071", "l": "Clathrin recruits PIK3C2A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951977", "l": "Acetylated RUNX3 binds to BRD2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641134", "l": "SMURF2 binds AXIN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54163", "l": "2-oxoglutarate + [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + O2 <=> [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051022", "l": "Rho GDP-dissociation inhibitor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447030", "l": "NrCAM binds Ankyrin-G (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102168", "l": "5-methyl-phenazine-1-carboxylate N-methyltransferase activity"}, {"i": "RHEA:49112", "l": "phenazine-1-carboxylate + S-adenosyl-L-methionine = 5-methyl-phenazine-1-carboxylate + S-adenosyl-L-homocysteine"}, {"i": "MetaCyc:RXN-11897"}, {"i": "EC:2.1.1.327", "l": "\"Phenazine-1-carboxylate N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961946", "l": "E2F1 binds the CDT1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950766", "l": "IL27RA dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848774", "l": "PTK6 binds DOK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39240", "l": "(2E)-triacontenoyl-CoA + H(+) + NADPH => NADP(+) + triacontanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10641", "l": "muconolactone => cis,cis-muconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008271", "l": "CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40570", "l": "AH2 + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + O2 <=> A + dTDP-beta-L-evernitrose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2197698", "l": "Src phosphorylate WASP,N-WASP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043754", "l": "dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1640164", "l": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.65", "l": "\"Peptidase 1 (mite)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451895", "l": "IL2RG binds JAK3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37448", "l": "O2 + tetracenomycin F1 => H(+) + H2O + tetracenomycin D3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18993", "l": "(9Z,12Z)-octadecadienoate + O2 = (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate"}, {"i": "EC:1.13.11.45", "l": "\"Linoleate 11-lipoxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9681616", "l": "AP2 binds chlorpromazine (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63329", "l": "2-(9Z-octadecenoyl)-glycerol + ATP => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49085", "l": "(-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase] => (-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432946", "l": "PARVB/Affixin interacts with alpha PIX (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48202", "l": "reduced [electron-transfer flavoprotein] + trans-2-undecenoyl-CoA => H(+) + oxidized [electron-transfer flavoprotein] + undecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51294", "l": "a quinol + L-methionyl-(S)-S-oxide-[protein] => a quinone + H2O + L-methionyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27959", "l": "cytidine + H2O => cytosine + D-ribose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13837", "l": "cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) = 4,5-dihydroxyphthalate + H(+) + NADH"}, {"i": "EC:1.3.1.64", "l": "\"Phthalate 4,5-cis-dihydrodiol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352921", "l": "1,3-bisphosphoglycerate + NADH + H+ <=> glyceraldehyde 3-phosphate + NAD+ + phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19878", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047873", "l": "dolichyl-phosphatase activity"}, {"i": "RHEA:13797", "l": "dolichyl phosphate + H2O = di-trans,poly-cis-dolichol + phosphate"}, {"i": "EC:3.1.3.51", "l": "\"Dolichyl-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392263", "l": "AVP(20-28) binds AVPR2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47614", "l": "a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38008", "l": "6-geranylgeranyl-2-methylbenzene-1,4-diol + S-adenosyl-L-methionine => 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617668", "l": "HOXB3 mRNA is translated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44085", "l": "ATP + CoA + heptadecanoate => AMP + diphosphate + heptadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34234", "l": "5-nitrosalicylate + O2 <=> 4-nitro-6-oxohepta-2,4-dienedioate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30609", "l": "AH2 + all-trans-zeta-carotene => A + all-trans-phytofluene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209944", "l": "25(OH)D binds GC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446391", "l": "Formation of the PINCH-ILK-parvin complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44202", "l": "12-methyloctadecanoyl-CoA + AMP + diphosphate => 12-methyloctadecanoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59273", "l": "L-cysteine => D-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50675", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O <=> [(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033444", "l": "AAG codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57147", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11769", "l": "diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate => 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114544", "l": "p115-RhoGEF activation of RHOA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28713", "l": "H(+)(out) + N-(4-aminobenzoyl)-L-glutamate(out) => H(+)(in) + N-(4-aminobenzoyl)-L-glutamate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51443", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (11S)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38157", "l": "(6E,10E)-geranyllinalool + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42590", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052735", "l": "tRNA (cytosine-3-)-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44530", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65918", "l": "H2O + kynurenate + L-alanine => L-kynurenine + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43006", "l": "2-aminoprop-2-enoate + CO2 + NH4(+) => H(+) + O-carbamoyl-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41925", "l": "(3R)-hydroxyoctadecanoyl-[ACP] => (2E)-octadecenoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001856", "l": "complement component C5a binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23076", "l": "4-chlorobenzoyl-CoA + chloride + NADP(+) = 2,4-dichlorobenzoyl-CoA + NADPH"}, {"i": "EC:1.21.1.2", "l": "\"2,4-dichlorobenzoyl-CoA reductase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090434", "l": "oleoyl-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1254251", "l": "ERBB4s80 binds YAP1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33543", "l": "ergosteryl palmitate + H2O = ergosterol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052683", "l": "(Z)-gamma-bisabolene synthase activity"}, {"i": "RHEA:26081", "l": "(2E,6E)-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate"}, {"i": "EC:4.2.3.40", "l": "\"(Z)-gamma-bisabolene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9637699", "l": "CpnT hydrolyses NAD+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218805", "l": "PKC autophosphorylates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102090", "l": "adrenaline O-methyltransferase activity"}, {"i": "MetaCyc:RXN-10909"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20110", "l": "alpha-D-ribose 1,5-bisphosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58792", "l": "ATP + Fe(III)-petrobactin(out) + H2O = ADP + Fe(III)-petrobactin(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20614", "l": "3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine => adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70427", "l": "PGM:Mg2+ isomerise G1P to G6P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624954", "l": "INPP5E translocates to the primary cilium (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814695", "l": "PERP binds desmosomes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015515", "l": "citrate:succinate antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19480", "l": "4-hydroxybenzoate + H(+) + NADPH + O2 <=> 3,4-dihydroxybenzoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9737035", "l": "L-Glutamate binds GRM1 (mGluR1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871373", "l": "BMX phosphorylates RUFY1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004167", "l": "dopachrome isomerase activity"}, {"i": "RHEA:13041", "l": "L-dopachrome = 5,6-dihydroxyindole-2-carboxylate"}, {"i": "EC:5.3.3.12", "l": "\"L-dopachrome isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65460", "l": "acetyl-CoA + hexan-1-ol = CoA + hexyl acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46363", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166387", "l": "The FA anion diffuses away laterally from UCP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-350769", "l": "trans-Golgi Network Coat Activation (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428127", "l": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61306", "l": "H(+) + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + UDP => N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617479", "l": "HOXA2 mRNA is translated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010844", "l": "recombination hotspot binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685604", "l": "SLAMF6 binds SLAMF6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684261", "l": "MAP3K8 is phosphorylated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34788", "l": "a 3beta-hydroxysteroid + NADP(+) => a 3-oxosteroid + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392513", "l": "Rap1 signal termination by Rap1GAPs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56776", "l": "(+)-pinoresinol + O2 + reduced [NADPH--hemoprotein reductase] = (+)-piperitol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "RHEA:56780", "l": "(+)-piperitol + O2 + reduced [NADPH--hemoprotein reductase] = (+)-sesamin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.19.74", "l": "\"(+)-piperitol/(+)-sesamin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32696", "l": "(2E)-geranyl diphosphate => (-)-car-3-ene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0071936", "l": "coreceptor activity involved in Wnt signaling pathway"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102992", "l": "2-methylbutyronitrile hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23801", "l": "H2O + L-methionine => 2-oxobutanoate + methanethiol + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873921", "l": "Binding of STAT1 to p-IFNGR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21223", "l": "L-dopa + O2 <=> 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60246", "l": "2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3] => 2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66436", "l": "NADP(+) + pentan-3-one = H(+) + NADPH + pent-1-en-3-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46219", "l": "H(+) + NADPH + progesterone <=> 3beta-hydroxypregn-4-ene-20-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14733", "l": "Ag(+)(in) + ATP + H2O = ADP + Ag(+)(out) + H(+) + phosphate"}, {"i": "EC:7.2.2.15", "l": "\"P-type Ag(+) transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10676", "l": "(2R,3S)-3-isopropylmalate = 2-isopropylmaleate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048001", "l": "erythrose-4-phosphate dehydrogenase activity"}, {"i": "RHEA:12056", "l": "D-erythrose 4-phosphate + H2O + NAD(+) = 4-phospho-D-erythronate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.72", "l": "\"Erythrose-4-phosphate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035647", "l": "3-oxo-delta(4,5)-steroid 5-beta-reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800793", "l": "PIDD1 translocates to the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49976", "l": "butanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + butanoyl-4'-phosphopantetheine + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22212", "l": "(2R,3R)-tartrate = (2R,3S)-tartrate"}, {"i": "EC:5.1.2.5", "l": "\"Tartrate epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10320", "l": "trans-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O"}, {"i": "EC:4.2.1.77", "l": "\"Trans-L-3-hydroxyproline dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39616", "l": "(3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA => (2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56019", "l": "H2O + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004118", "l": "cGMP-stimulated cyclic-nucleotide phosphodiesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52520", "l": "O2 + prostaglandin E1 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy prostaglandin E1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14908", "l": "5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate <=> 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188025", "l": "Flagellin binds to TLR5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47171", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+) <=> 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63434", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + a di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) => 1,2,3-tri-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31985", "l": "abieta-7,13-dien-18,18-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-ol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47021", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O => [DsrC protein]-disulfide + 3 AH2 + 2 H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43454", "l": "4-hydroxy-6-pentylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + hexanoyl-CoA + 2 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32829", "l": "ADP + H(+) + methionine(in) + phosphate => ATP + H2O + methionine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54675", "l": "(+)-kolavenyl diphosphate + H2O <=> (+)-kolavelool + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56072", "l": "a 2-acylphloroglucinol + UDP-alpha-D-glucose = a 2-acylphloroglucinol 1-O-beta-D-glucoside + UDP"}, {"i": "EC:2.4.1.358", "l": "\"Acylphloroglucinol glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10341", "l": "(2E,6E)-farnesyl diphosphate => (-)-vetispiradiene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21411", "l": "H2O + L-phenylalanine + NAD(+) <=> 3-phenylpyruvate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49947", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate <=> (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60119", "l": "2-oxoglutarate + methylphosphonate + O2 <=> CO2 + hydroxymethylphosphonate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196773", "l": "COASY phosphorylates DP-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44265", "l": "eicosanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-nonadecylpyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60894", "l": "a 5'-end phospho-ribonucleoside in snoRNA + H(+) + NAD(+) => a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010943", "l": "NADPH pyrophosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171026", "l": "Guanine nucleotide exchange on RAL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45830", "l": "3-oxohexanoyl-CoA + H(+) + NADH => (3R)-hydroxyhexanoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952996", "l": "E2F7 forms homodimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380574", "l": "Dopamine synaptic vesicle docking and priming (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45616", "l": "H2O + N-hexanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexanoyl ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36028", "l": "CoA + NAD(+) + propanal => H(+) + NADH + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839031", "l": "Dimerization of cytosolic FGFR1 fusion proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19242", "l": "ent-kaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] => ent-7alpha-hydroxykaur-16-en-19-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061608", "l": "nuclear import signal receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5252072", "l": "AZGP1 binds PIP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033401", "l": "UUU codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166214", "l": "FA anion flip-flops to the opposite surface (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10056", "l": "(3S)-3-aminobutanoyl-CoA = (2E)-butenoyl-CoA + NH4(+)"}, {"i": "EC:4.3.1.14", "l": "\"3-aminobutyryl-CoA ammonia-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218805", "l": "PKC autophosphorylates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44446", "l": "a fatty acid + a monoacylglycerol + H(+) => a 1,2-diacylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170159", "l": "Translocation of Cdc25 to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211910", "l": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32585", "l": "6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+) => dihydrocarvone + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25040", "l": "ATP + L-seryl-tRNA(Sec) <=> ADP + O-phospho-L-seryl-tRNA(Sec)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008960", "l": "phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35247", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA(in) + ATP + H2O = ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40531", "l": "2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + neopikromycin + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11318", "l": "a nitrile + H2O => an aliphatic aldoxime"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47469", "l": "(2E,4E)-tetradecadienoyl-CoA => (3E,5Z)-tetradecadienoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45227", "l": "(3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA <=> (2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.98.-", "l": "\"With other, known, acceptors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56728", "l": "4-hydroxy-all-trans-beta-carotene + AH2 + O2 = 4,4-dihydroxy-all-trans-beta-carotene + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211950", "l": "CYP24A1 24-hydroxylates CTL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210285", "l": "Trans-homophilic interaction of PECAM-1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247960", "l": "Activation of p38 MAPK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43482", "l": "1-O-methyl-8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55958", "l": "(12R)-hydroxy-(9Z)-octadecenoate + A + H2O => (9Z)-octadecenoate + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43933", "l": "3beta-hydroxyandrost-5-en-17-one + NAD(+) => androst-5-ene-3,17-dione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16209", "l": "Co-precorrin-8X = cob(II)yrinate"}, {"i": "EC:5.4.99.60", "l": "\"Cobalt-precorrin-8 methylmutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23438", "l": "2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate => 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62855", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11323", "l": "UDP-beta-L-arabinopyranose <=> UDP-alpha-D-xylose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "70.245698090881746", "identifiers": [{"i": "GO:0016405", "l": "CoA-ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048156", "l": "tau protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444171", "l": "Receptor FFAR2 binds carboxylates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52687", "l": "NAD(+) + pyridoxine <=> H(+) + NADH + pyridoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604731", "l": "Autocatalytic activation of MMP3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32435", "l": "dihydrocarvone + H(+) + NADPH + O2 = 4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18701", "l": "arsenite + H2O + 2 oxidized [azurin] = arsenate + 3 H(+) + 2 reduced [azurin]"}, {"i": "EC:1.20.9.1", "l": "\"Arsenate reductase (azurin)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43534", "l": "a ribonucleoside 5'-phosphate + phosphate => a ribonucleoside 3',5'-bisphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1253343", "l": "WWOX binds ERBB4s80 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23033", "l": "2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62788", "l": "2 fonsecin B + H(+) + NADPH + O2 = aurasperone B + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44893", "l": "an N-(2-hydroxyacyl)-sphinganine + UDP-alpha-D-galactose => an N-(2-hydroxyacyl)-beta-D-galactosyl-sphinganine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44497", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylethanolamine => 2-(acylamino)ethyl fatty acid + a monoacyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164528", "l": "RNase H-mediated cleavage of the template strand (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029468", "l": "Conversion of PA into DAG by PAP-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26179", "l": "1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine <=> 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71849", "l": "LDH tetramer reduces PYR to LACT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66430", "l": "D-arabinose(in) + H(+)(in) => D-arabinose(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157926", "l": "NICD1 traffics to nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9668395", "l": "CHMP7 binds CC2D1B (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27728", "l": "2-hydroxy-3-oxopropanoate + pyruvate => 5-dehydro-4-deoxy-D-glucarate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018752", "l": "epsilon-caprolactam lactamase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63621", "l": "ATP + dodecanoate + holo-[ACP] => AMP + diphosphate + dodecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23203", "l": "H2O + N(6)-methyl-L-lysine + O2 <=> formaldehyde + H2O2 + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-140769", "l": "factor VII -> factor VIIa (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210439", "l": "glutamate uptake by astrocytes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106222", "l": "long noncoding RNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33414", "l": "(S)-malyl N-acetyl-alpha-D-glucosaminide + H2O <=> (S)-malyl alpha-D-glucosaminide + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16144", "l": "2'-deoxymugineate + NAD(+) <=> 3''-deamino-3''-oxonicotianamine + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3149519", "l": "MMACHC decyanates CNCbl (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482629", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29408", "l": "2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + NADPH + O2 => 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19400", "l": "(R)-4'-phosphopantothenate + CTP + L-cysteine <=> CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66680", "l": "ATP + coproporphyrinogen III(in) + H2O = ADP + coproporphyrinogen III(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50483", "l": "acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39168", "l": "H(+) + malonyl-CoA + tetradecanoyl-CoA => 3-oxohexadecanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854736", "l": "FLT3LG dimer:FLT3 binds FLT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58329", "l": "(Z)-non-6-en-1-ol + NADP(+) => (Z)-non-6-enal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31235", "l": "(4S)-4-hydroxy-L-glutamate + 2-oxoglutarate = (4R)-4-hydroxy-2-oxoglutarate + L-glutamate"}, {"i": "EC:2.6.1.23", "l": "\"4-hydroxyglutamate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46870", "l": "a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204364", "l": "ROBO1 binds SLIT2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55136", "l": "ATP + D-alanine + H(+) = D-alanyl-5'-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948230", "l": "P3HB binds 4-Hyp-collagen propeptides (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31096", "l": "2-methylpropanoyl-CoA + A => (2E)-2-methylpropenoyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0019905", "l": "syntaxin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869590", "l": "The APOE gene transcription is stimulated by the complex of TFAP2A homodimer and DEK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53693", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O => H(+) + prostaglandin E2 + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080108", "l": "S-alkylthiohydroximate lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38806", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34758", "l": "H2O + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine <=> D-glucose + N-acyl-15-methylhexadecasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43956", "l": "15-methylhexadecanoate + H(+) + NADPH + O2 = H2O + NADP(+) + omega-hydroxy-15-methyl-hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22944", "l": "3beta-hydroxy-5beta-pregnane-20-one + NADP(+) = 5beta-pregnan-3,20-dione + H(+) + NADPH"}, {"i": "EC:1.1.1.277", "l": "\"3-beta-hydroxy-5-beta-steroid dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-167415", "l": "G-protein alpha subunit is inactivated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42017", "l": "cortisone + NAD(+) => 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086087", "l": "voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59623", "l": "H2O + N(2)-(4-aminobutanoyl)-L-lysine <=> 4-aminobutanoate + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31016", "l": "H(+) + indole-3-carboxylate => CO2 + indole"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28022", "l": "ATP + holo-[ACP] + octanoate = AMP + diphosphate + octanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29852", "l": "H2O + UDP-N-acetyl-alpha-D-galactosamine => 2 H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952128", "l": "RUNX3 binds TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21775", "l": "cytidine(6666) in apoB mRNA + H(+) + H2O <=> NH4(+) + uridine(6666) in apoB mRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53681", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 => 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955844", "l": "RBKS phosphorylates ribose to R5P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964886", "l": "EPSP from shikimate 3-phosphate (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046029", "l": "mannitol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070260", "l": "5'-tyrosyl-DNA phosphodiesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21963", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + [protein]-disulfide + H(+) + H2O <=> 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + [protein]-dithiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029454", "l": "Autophosphorylation of PAK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.282", "l": "\"Phenolphthiocerol/phthiocerol/phthiodiolone dimycocerosyl transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70482", "l": "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56987", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (6E)-nerolidol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350598", "l": "Arginine<=>Agmatine+CO2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3791319", "l": "NID1 degradation by MMP19 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66414", "l": "ADP + glutathione(out) + H(+) + phosphate + taurochenodeoxycholate(out) => ATP + glutathione(in) + H2O + taurochenodeoxycholate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42509", "l": "6-acetamido-2-oxohexanoate + H2O + NAD(+) => 5-acetamidopentanoate + CO2 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23771", "l": "a fatty acyl-CoA + sphing-4-enine <=> an N-acylsphing-4-enine + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42511", "l": "6-acetamido-2-oxohexanoate + H2O + NAD(+) <=> 5-acetamidopentanoate + CO2 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047826", "l": "D-lysine 5,6-aminomutase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202111", "l": "AKT1 phosphorylates eNOS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350058", "l": "Formation of CSL NCOR corepressor complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050476", "l": "acetylenedicarboxylate decarboxylase activity"}, {"i": "RHEA:17733", "l": "acetylenedicarboxylate + H(+) + H2O = CO2 + pyruvate"}, {"i": "EC:4.1.1.78", "l": "\"Acetylenedicarboxylate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35372", "l": "2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A => (beta-L-Ara4N)2-(Kdo)2-lipid A + 2 di-trans,octa-cis-undecaprenyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38250", "l": "(9Z)-hexadecenoyl-CoA + hexadecan-1-ol <=> 1-O-hexadecyl (9Z)-hexadecenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62227", "l": "H(+) + NADPH + neopatulin <=> (E)-ascladiol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37540", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58289", "l": "25-substituted-cholesterol + beta-D-glucosyl-N-octanoylsphing-4E-enine => 25-substituted-cholesteryl beta-D-glucoside + N-octanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63161", "l": "H2O + N-(15Z-tetracosenoyl)-taurine => (15Z)-tetracosenoate + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8949580", "l": "F1Fo ATP synthase dimerizes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804253", "l": "MDM2 ubiquitinates JMY (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849463", "l": "PTK6 phosphorylates SFPQ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25991", "l": "(5R)-albaflavenol + H(+) + NADPH + O2 <=> albaflavenone + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66101", "l": "3-(4-hydroxyphenyl)pyruvate + L-kynurenine => H2O + kynurenate + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25529", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56023", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51994", "l": "an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => an (E)-omega-(methylsulfanyl)-alkanal oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54558", "l": "an adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + diphosphate => 5'-end ribonucleotide-tRNA(His) + ATP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013021", "l": "GDIs block activation of RHOB (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.2.2", "l": "\"Dihydropyrimidinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62209", "l": "3-methylphenol + O2 + reduced [NADPH--hemoprotein reductase] => 3-hydroxybenzyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111956", "l": "Calmodulin activates Cam-PDE 1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53202", "l": "17beta,19-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44454", "l": "3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12073", "l": "an (S)-2-haloacid + H2O => a (2S)-2-hydroxycarboxylate + a halide anion + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003881", "l": "CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:1903425", "l": "fluoride transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34396", "l": "L-phenylalanine => L-beta-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004616", "l": "phosphogluconate dehydrogenase (decarboxylating) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24689", "l": "H2O + N-formylmethanofuran <=> formate + methanofuran"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45847", "l": "(3R)-hydroxyoctanoyl-CoA + NADP(+) <=> 3-oxooctanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49140", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:4.2.1.164", "l": "\"dTDP-4-dehydro-2,6-dideoxy-D-glucose 3-dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205682", "l": "Parkin promotes the ubiquitination of mitochondrial substrates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65454", "l": "CoA + ethyl hexanoate => ethanol + hexanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58734", "l": "5-methyl-CMP + diphosphate + H(+) => 5-methyl-CTP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399941", "l": "Rac1 binds PlexinA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044103", "l": "L-arabinose 1-dehydrogenase (NADP+) activity"}, {"i": "EC:1.1.1.376", "l": "\"L-arabinose 1-dehydrogenase (NAD(P)(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56741", "l": "globoside Gb3Cer + UDP-alpha-D-galactose => GalGb3Cer + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59588", "l": "ATP + beta-alanine + L-ornithine = ADP + beta-alanyl-L-ornithine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65901", "l": "3-hydroxy-L-kynurenine + glyoxylate => glycine + H2O + xanthurenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047329", "l": "phosphoramidate-hexose phosphotransferase activity"}, {"i": "MetaCyc:2.7.1.62-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30859", "l": "dITP + H2O = dIDP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23152", "l": "a ubiquinone + H(+) + NADH = a ubiquinol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54178", "l": "a long-chain fatty acyl-[ACP] + H(+) + NADPH => a long-chain fatty aldehyde + holo-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22601", "l": "H2O + N-acetyl-9-O-acetylneuraminate => acetate + H(+) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0019152", "l": "acetoin dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22403", "l": "androstan-3alpha,17beta-diol + NAD(+) <=> 17beta-hydroxyandrostanone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16666", "l": "(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O => (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22604", "l": "D-mannose = D-fructose"}, {"i": "EC:5.3.1.7", "l": "\"Mannose isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39403", "l": "(2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH = (19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52337", "l": "a long-chain fatty acid + ATP + H(+) => a long-chain fatty acyl-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58659", "l": "a 5'-(5'-phospho)-ribonucleoside-RNA + S-adenosyl-L-methionine <=> a 5'-(5'-phosphomethyl)-ribonucleoside-RNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44480", "l": "3,4-dihydroxy-5-all-trans-heptaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-heptaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18890", "l": "D-glucose 6-phosphate + UDP-alpha-D-glucose => alpha,alpha-trehalose 6-phosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30510", "l": "2-demethylmenaquinone-8 + H(+) + NADH <=> 2-demethylmenaquinol-8 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0042296", "l": "ISG15 transferase activity"}, {"i": "REACT:R-HSA-5653754", "l": "UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0051880", "l": "G-quadruplex DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11830", "l": "H(+) + RNA(n)-2'- phosphate => H2O + RNA(n)-2',3'-cyclic phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174171", "l": "Association of Cyclin A with the APC/C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709317", "l": "CO binds to free ferrohemoglobin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5658435", "l": "RAS GAPs bind RAS:GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38263", "l": "(2R,3S)-beta-methylmalyl-CoA = 2-methylfumaryl-CoA + H2O"}, {"i": "EC:4.2.1.148", "l": "\"2-methylfumaryl-CoA hydratase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030293", "l": "transmembrane receptor protein tyrosine kinase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33133", "l": "3-phenylpyruvate + tetrahydrotyrosine => L-phenylalanine + tetrahydro-4-hydroxyphenylpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28695", "l": "hydrogencarbonate(in) = hydrogencarbonate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381091", "l": "IRE1 dimer autophosphorylates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63405", "l": "3,6-dichloropyridine-2,5-diol + FADH2 + O2 => 6-chloro-3-hydroxypyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44707", "l": "a 2,3-saturated acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.28"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944104", "l": "PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730862", "l": "Autophosphorylation of LYN kinase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13246", "l": "D-threo-isocitrate => glyoxylate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662613", "l": "MT3 exchanges zinc for copper (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38464", "l": "a 1-acyl-sn-glycerol + an acyl-CoA => a 1,2-diacyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168921", "l": "TRIF:activated TLR3/TLR4 complex recruits RIP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58539", "l": "glycine + hexadecanoyl-CoA <=> CoA + H(+) + N-hexadecanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19676", "l": "1,2,3-trihydroxybenzene + O2 <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57772", "l": "3-nitrotoluene + NADH + O2 = 4-methylcatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912407", "l": "NOTCH2 gene transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52102", "l": "(9Z)-octadecenoate + 5-hydroxy-octadecanoate + H(+) => 5-(9Z-octadecenoyloxy)-octadecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30377", "l": "(+)-thujopsene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49008", "l": "aurachin C + H(+) + NADPH + O2 = aurachin C epoxide + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-453342", "l": "PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005157", "l": "macrophage colony-stimulating factor receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39710", "l": "a long-chain fatty acyl-CoA(out) <=> a long-chain fatty acyl-CoA(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036201", "l": "ent-isokaurene C2-hydroxylase activity"}, {"i": "RHEA:56336", "l": "ent-isokaurene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = ent-isokaurene-2beta,3beta-diol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.76", "l": "\"Ent-isokaurene C2/C3-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66415", "l": "ATP + glutathione(in) + H2O + taurochenodeoxycholate(in) <=> ADP + glutathione(out) + H(+) + phosphate + taurochenodeoxycholate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36971", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-allose"}, {"i": "EC:5.1.3.27", "l": "\"dTDP-4-dehydro-6-deoxy-D-glucose 3-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696822", "l": "AKR1B15 reduces EST17b to E1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450348", "l": "Activated human JNKs migrate to nucleoplasm (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11774", "l": "6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH => 6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.19", "l": "\"(R)-specific secondary-alkylsulfatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36334", "l": "ATP + dimethylallyl diphosphate <=> diphosphate + N(6)-(dimethylallyl)adenosine 5'-triphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004096", "l": "catalase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2197691", "l": "WIP binds WASP,N-WASP, activating them (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62680", "l": "YWA1 = H(+) + H2O + norrubrofusarin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19471", "l": "H(+) + NAD(+) + 2 nitrate => NADH + 2 nitric oxide + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31679", "l": "O2 + prosolanapyrone II = H2O2 + prosolanapyrone III"}, {"i": "EC:1.1.3.42", "l": "\"Prosolanapyrone-II oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41765", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD3 (d18:1(4E)) => CMP + ganglioside GT3 (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850818", "l": "SPINK9 binds KLK5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9652264", "l": "ERBB2 binds TKIs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627089", "l": "CASP9 is phosphorylated at T125 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46624", "l": "a D-5-monosubstituted hydantoin = a L-5-monosubstituted hydantoin"}, {"i": "EC:5.1.99.5", "l": "\"Hydantoin racemase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801776", "l": "REG3A binds bacterial phospholipids (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606602", "l": "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49325", "l": "(5R,6S)-5,6-epoxi-capsanthin => all-trans-capsorubin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9017507", "l": "RHOJ binds effectors at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65343", "l": "acetyl-CoA + L-threonyl-[protein] <=> CoA + O-acetyl-L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20170", "l": "H(+) + NADPH + O2 + tetradecanoyl-CoA => (11E)-tetradecenoyl-CoA + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28430", "l": "D-allose 6-phosphate = D-allulose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097748", "l": "3'-5' RNA polymerase activity"}, {"i": "RHEA:57528", "l": "5'-end ribonucleotide-RNA + a ribonucleoside 5'-triphosphate + ATP + H2O = 5'-phospho-ribonucleosidyl-ribonucleotide-RNA + AMP + 2 diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62911", "l": "nor-toralactone + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + toralactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44104", "l": "decanal + H2O + NAD(+) = decanoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009824", "l": "AMP dimethylallyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14954", "l": "H(+) + NADPH + O2 + tetradecanoyl-CoA => (11Z)-tetradecenoyl-CoA + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23120", "l": "a dipeptide(out) + ATP + H2O = a dipeptide(in) + ADP + H(+) + phosphate"}, {"i": "EC:7.4.2.9", "l": "\"ABC-type dipeptide transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46325", "l": "3-oxochol-4-en-22-oyl-CoA + A => 3-oxochola-4,17-dien-22-oyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65355", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate <=> 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40983", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = (9Z)-octadecenoate + 1,3-dihexadecanoylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28006", "l": "H2O + N(alpha)-methyl-L-tryptophan + O2 = formaldehyde + H2O2 + L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64740", "l": "H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine = 3-methyl-3-sulfanylhexan-1-ol + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43458", "l": "(2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41275", "l": "H2O + N-eicosanoyl-sphing-4-enine = eicosanoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23233", "l": "4 [Fe(III)cytochrome c] + hydrazine => 4 [Fe(II)cytochrome c] + 4 H(+) + N2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40265", "l": "3-oxohexadecanedioyl-CoA + H(+) + NADH => (3R)-hydroxyhexadecanedioyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709366", "l": "CO translocates from cytosol to mitochondrial inner membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5387392", "l": "processing defective Hh variants are degraded by the proteasome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015471", "l": "nucleoside-specific channel forming porin activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65157", "l": "2-oxoglutarate + O2 + preaustinoid A2 => CO2 + H2O + preaustinoid A3 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48443", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol <=> a fatty acid + H(+) + long chain 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052792", "l": "endo-xylogalacturonan hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66845", "l": "asperterpenoid A + O2 + reduced [NADPH--hemoprotein reductase] => asperterpenoid C + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.15.2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001512", "l": "dihydronicotinamide riboside quinone reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24139", "l": "3'-phosphoadenylyl sulfate + a primary amine <=> a sulfamate + adenosine 3',5'-bisphosphate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170978", "l": "p-FRS2:CRKL binds C3G (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43679", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106211", "l": "inositol-5-diphosphate-1,3,4,6-tetrakisphosphate diphosphatase activity"}, {"i": "RHEA:59500", "l": "5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879459", "l": "F-actin capping protein is a heterodimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28026", "l": "[thioredoxin]-disulfide + dUDP + H2O = [thioredoxin]-dithiol + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17246", "l": "3-hydroxyanthranilate + O2 => 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853405", "l": "TPX2 binds AURKA at centrosomes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864431", "l": "TFAP2A,TFAP2C homodimers stimulate CGB3 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42817", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol => cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177922", "l": "EGFR dimerization (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18773", "l": "[methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M = [Co(I) methylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64570", "l": "ilicicolin H => 3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951951", "l": "RUNX3 binds EP300 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052798", "l": "beta-galactoside alpha-2,3-sialyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5226999", "l": "ADD1:ADD3 binds DMTN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1299359", "l": "Activation of TALK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17054", "l": "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate => beta-D-fructose 6-phosphate + D-erythrose 4-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10656", "l": "guanidinoacetate + S-adenosyl-L-methionine = creatine + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.2", "l": "\"Guanidinoacetate N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31365", "l": "2 H(+) + NADPH + oxidized coenzyme F420-(gamma-Glu)(n) => NADP(+) + reduced coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37735", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine = 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32978", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + 2 H2O <=> 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22521", "l": "all-trans-retinal + H2O + O2 => all-trans-retinoate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15246", "l": "a monoacylglycerol + H2O => a fatty acid + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22479", "l": "4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+) <=> 4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0005294", "l": "neutral L-amino acid secondary active transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26344", "l": "L-selenocysteine + S-methyl-L-methionine <=> H(+) + L-methionine + Se-methyl-L-selenocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59464", "l": "NADP(+) + octadecan-1-ol = H(+) + NADPH + octadecanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38847", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109813", "l": "GRB2-1 binds SOS1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032577", "l": "phosphatidylcholine:cardiolipin O-linoleoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018754", "l": "GDIs bind RHOH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48139", "l": "ganglioside GM3 + H2O <=> beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700120", "l": "PTN and MDK bind to PTPRZ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18462", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA => a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29698", "l": "cob(I)inamide(in) <=> cob(I)inamide(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211224", "l": "Association of DFF40 with DFF45 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983300", "l": "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218855", "l": "BCAR1 binds p-7Y-PTK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64297", "l": "(4S,8R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,16,19-heptaen-18-one + H(+) + NADPH => (4S,8R,16R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,19-hexaen-18-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417898", "l": "P2Y4 receptor can bind to UTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24371", "l": "L-ornithine <=> L-proline + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395784", "l": "Nascent CMs transform into mature CMs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196753", "l": "2xPPCS ligates PPanK with Cys (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29261", "l": "(2R,3R)-tartrate(in) + succinate(out) => (2R,3R)-tartrate(out) + succinate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176318", "l": "Loading of claspin onto DNA during replication origin firing (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033815", "l": "biphenyl synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202604", "l": "Formation of a heteromeric BMP receptor complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158925", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28094", "l": "di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate"}, {"i": "EC:3.6.1.27", "l": "\"Undecaprenyl-diphosphate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61231", "l": "H2O + L-histidine + O2 <=> 3-(imidazol-5-yl)pyruvate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9681616", "l": "AP2 binds chlorpromazine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379977", "l": "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952996", "l": "E2F7 forms homodimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781814", "l": "USP19 deubiquitinates RNF123 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22810", "l": "2,6-dihydroxynicotinate + H2O2 => 6-hydroxynicotinate + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174224", "l": "Dissociation of Cdc20 from APC/C complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187617", "l": "argininosuccinate <=> fumarate + arginine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-167415", "l": "G-protein alpha subunit is inactivated (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432295", "l": "GPVI binds Fyn and Lyn (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9615249", "l": "ARBs bind AGRT1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51588", "l": "isopyridoxal + NAD(+) = 5-pyridoxolactone + H(+) + NADH"}, {"i": "EC:1.1.1.416", "l": "\"Isopyridoxal dehydrogenase (5-pyridoxolactone-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4341072", "l": "SUMOylation of RARA with SUMO2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0005518", "l": "collagen binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38028", "l": "(E)-caffeate + hydrocaffeoyl-CoA => (E)-caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165680", "l": "Formation of active mTORC1 complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15980", "l": "(S)-4-hydroxymandelonitrile <=> 4-hydroxybenzaldehyde + hydrogen cyanide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16409", "l": "1,2-dihydrovomilenine + NADP(+) = H(+) + NADPH + vomilenine"}, {"i": "EC:1.5.1.32", "l": "\"Vomilenine reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202717", "l": "Heterodimerization of CEACAMs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64669", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46417", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (6Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22045", "l": "ATP + H(+)(in) + H2O + K(+)(out) => ADP + 2 H(+)(out) + K(+)(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800793", "l": "PIDD1 translocates to the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679031", "l": "Defective ABCC2 does not transport BMG,BDG from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51136", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 2 O2 = (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032781", "l": "WWTR1 (TAZ) binds TEAD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21489", "l": "dalnigrein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O => beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalnigrein + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10893", "l": "(2R,3S)-3-isopropylmalate + NAD(+) => (2S)-2-isopropyl-3-oxosuccinate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004439", "l": "phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"}, {"i": "MetaCyc:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38101", "l": "a ribonucleoside 5'-diphosphate + phytyl diphosphate => a ribonucleoside 5'-triphosphate + phytyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35675", "l": "H(+) + L-serine + tetradecanoyl-CoA = 3-oxohexadecasphinganine + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665412", "l": "ERBB2 ECD mutants bind TKIs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56714", "l": "H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57935", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) <=> beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.33"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102696", "l": "cis-zeatin UDP glycosyltransferase activity"}, {"i": "MetaCyc:RXN-4734"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.2.1", "l": "\"DNA topoisomerase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031733", "l": "CCR8 chemokine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190265", "l": "FGFR4 binds to FGF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44741", "l": "27-O-demethylrifamycin SV + S-adenosyl-L-methionine => H(+) + rifamycin SV + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28600", "l": "acetate + L-lysine => H2O + N-acetyl-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1671687", "l": "PRLR activation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57209", "l": "glyoxal + L-cysteinyl-[protein] => S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878117", "l": "RUNX3 binds ZFHX3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008696", "l": "IL37(?-218) translocates from the cytosol to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201603", "l": "Caspase-mediated cleavage of PKC theta (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647632", "l": "CASP3 cleaves GSDME (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63528", "l": "[thioredoxin]-dithiol + H2O2 = [thioredoxin]-disulfide + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13038", "l": "ATP + H(+) + H2O => ITP + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34801", "l": "3-oxo-5,6-didehydrosuberyl-CoA + CoA => 2,3-didehydroadipoyl-CoA + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56376", "l": "3-bromo-4,5-dihydroxybenzoate + bromide + 3 H(+) + NADPH + O2 = 3,5-dibromobenzene-1,2-diol + CO2 + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9710353", "l": "GSDMD (1-275) binds cardiolipin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58716", "l": "FADH2-C4alpha-hydroperoxide + NADH + rifampicin = FADH2 + H(+) + H2O + NAD(+) + rifampicin hemiaminal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24238", "l": "2 [Fe(II)cytochrome c] + 3 H(+) + trimethylamine N-oxide => 2 [Fe(III)cytochrome c] + H2O + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719375", "l": "Defective DPM2 does not transfer mannose to DOLP to form DOLPman (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26458", "l": "ethylnitronate + FMNH2 + O2 = acetaldehyde + FMN + 2 H(+) + H2O + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21897", "l": "(R)-1-aminopropan-2-yl phosphate + adenosylcob(III)yrate + ATP => adenosylcob(III)inamide phosphate + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15149", "l": "O2 + pyridoxine 5'-phosphate = H2O2 + pyridoxal 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102474", "l": "eriodictyol dibenzoylmethane tautomer 6C-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-14080"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.7", "l": "\"N-formylmethionyl-peptidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022849", "l": "glutamate-gated calcium ion channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29677", "l": "glycerol(out) => glycerol(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-981713", "l": "C4b binds to cell surface (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62360", "l": "FMNH2 + O2 + uracil = (Z)-3-ureidoacrylate + FMN-N(5)-oxide + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432121", "l": "LDL binds to LRP8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13503", "l": "ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate => ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29095", "l": "5 H(+)(in) + NADH + ubiquinone-8 = 4 H(+)(out) + NAD(+) + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396399", "l": "Fibrillins bind BMPs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694462", "l": "ABHD6,12 hydrolyse 3AG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698962", "l": "Binding of pPR-AP to pAP to form the pPR-AP:pAP Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0150043", "l": "structural constituent of synapse-associated extracellular matrix"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52808", "l": "adenosine in U6 snRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.346", "l": "\"U6 snRNA m(6)A methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786421", "l": "CHIA hydrolyses chitin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18696", "l": "H2O + penicillin <=> 6-aminopenicillanate + a carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662620", "l": "MT3 binds cadmium (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72127", "l": "Formation of the Spliceosomal B Complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49741", "l": "2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate => CO2 + deoxyviolacein + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17633", "l": "a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate"}, {"i": "EC:3.2.1.31", "l": "\"Beta-glucuronidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21381", "l": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA => AMP + diphosphate + phytanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55229", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37818", "l": "(R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 <=> 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46582", "l": "25-hydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + vitamin D2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14743", "l": "4-methylene-L-glutamate + NH4(+) => 4-methylene-L-glutamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49458", "l": "(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate + pyruvate => (2S)-2-amino-4-deoxychorismate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58506", "l": "(3Z)-2-oxo-4-carboxy-3-hexenedioate => (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12026", "l": "D-glucose + O-sinapoylcholine => 1-O-(trans-sinapoyl)-beta-D-glucose + choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29550", "l": "H2O + UDP-N-acetyl-alpha-D-glucosamine <=> 2 H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-74059", "l": "PDE6 hydrolyses cGMP to GMP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2248891", "l": "Active ARSA translocates to the lysosome (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22908", "l": "3',5'-cyclic AMP + H(+) + H2O = 3',5'-cyclic IMP + NH4(+)"}, {"i": "EC:3.5.4.46", "l": "\"cAMP deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36890", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + AH2 + O2 <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33904", "l": "H2O + O2 + pseudooxynicotine => 4-oxo-4-(pyridin-3-yl)butanal + H2O2 + methylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014454", "l": "RHOG translocates to the ER membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16327", "l": "diphosphate + UDP-alpha-D-glucuronate => 1-phospho-alpha-D-glucuronate + H(+) + UTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40694", "l": "1-hexadecanoylglycerone 3-phosphate + pentadecan-1-ol <=> 1-O-pentadecylglycerone 3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14523", "l": "(2E)-geranial + H(+) + NADPH => (2E)-geraniol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047718", "l": "indanol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023196", "l": "PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66161", "l": "hexanoyl-CoA + tyramine => CoA + H(+) + N-hexanoyltyramine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57374", "l": "(6S)-NADPHX => H2O + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16346", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (3E,7E)-dolabella-3,7-dien-18-ol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27909", "l": "butanoyl-CoA + NADP(+) <=> (2E)-butenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050382", "l": "uracil-5-carboxylate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43680", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050086", "l": "mannitol 2-dehydrogenase activity"}, {"i": "RHEA:12084", "l": "D-mannitol + NAD(+) = D-fructose + H(+) + NADH"}, {"i": "EC:1.1.1.67", "l": "\"Mannitol 2-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202969", "l": "Caspase mediated cleavage of beta-catenin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35653", "l": "an N-acyl-(4R)-4-hydroxysphinganine + CoA + H(+) => (4R)-hydroxysphinganine + a fatty acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39966", "l": "2-hexadecanoylglycerol + H2O <=> glycerol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36474", "l": "3,4,5-trihydroxybenzoate(out) + H(+)(out) <=> 3,4,5-trihydroxybenzoate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54993", "l": "3 A + FMN + H2O + L-glutamate + O2 => 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 3 AH2 + CO2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12413", "l": "(2R)-3-phosphoglycerate + H2O => (R)-glycerate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39801", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH => 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43525", "l": "L-allo-threonine + NADP(+) => aminoacetone + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65753", "l": "2-oxoglutarate + L-glutamate + O2 => (3R)-3-hydroxy-L-glutamate + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19185", "l": "glyoxylate + H2O + propanoyl-CoA = 2-hydroxyglutarate + CoA + H(+)"}, {"i": "EC:2.3.3.11", "l": "\"2-hydroxyglutarate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "68.3621111081913", "identifiers": [{"i": "GO:0003729", "l": "mRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36067", "l": "Co-precorrin-6B + S-adenosyl-L-methionine = Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.196", "l": "\"Cobalt-precorrin-6B (C(15))-methyltransferase (decarboxylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655347", "l": "Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0050145", "l": "nucleoside monophosphate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55656", "l": "2 A + a carotenoid beta-end derivative = a carotenoid chi-end derivative + 2 AH2"}, {"i": "EC:1.3.99.40", "l": "\"Carotenoid chi-ring synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55968", "l": "(+)-kolavelool + S-adenosyl-L-methionine = (+)-O-methylkolavelool + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.347", "l": "\"(+)-O-methylkolavelool synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380157", "l": "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975874", "l": "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734687", "l": "ORC6 is phosphorylated on T195 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58134", "l": "AH2 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + serpentine => A + ajmalicine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052591", "l": "sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433501", "l": "Interaction of other adapter proteins with p-KIT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20092", "l": "acetyl-CoA + L-leucine <=> CoA + H(+) + N-acetyl-L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69173", "l": "Joining of adjacent Okazaki fragments (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40585", "l": "CoA + H(+) + hexanedioate => H2O + hexanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55238", "l": "(9Z)-octadecenoate + 1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H(+) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203977", "l": "SAR1 Activation And Membrane Binding (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692764", "l": "MAPK6 binds CCND3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45547", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047622", "l": "adenosine nucleosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700156", "l": "Active ALK dimer binds IRS1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34043", "l": "5-phospho-alpha-D-ribose 1-diphosphate + neamine = 5''-phosphoribostamycin + diphosphate"}, {"i": "EC:2.4.2.49", "l": "\"Neamine phosphoribosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2046175", "l": "Further sulfation on galactose residues produces KSPG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64821", "l": "2-phenylacetamide + H2O => 2-phenylacetate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28296", "l": "(E)-beta-caryophyllene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205231", "l": "Dimerization of KIT upon SCF binding (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373075", "l": "Metabotropic glutamate receptors bind glutamate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0060590", "l": "ATPase regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112379", "l": "Recruitment of elongation factors to form elongation complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-912627", "l": "CBL ubiquitinates PI3K (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47012", "l": "[DsrC protein]-disulfide + H(+) + hydrogen sulfide = [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43012", "l": "L-homocysteine = 2-aminobut-2-enoate + H(+) + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66394", "l": "ADP + H(+) + phosphate + prostaglandin E1(out) => ATP + H2O + prostaglandin E1(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070991", "l": "medium-chain-acyl-CoA dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17662", "l": "ATP + CoA + succinate => ADP + phosphate + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59194", "l": "diphosphate + icosanoyl-AMP => ATP + eicosanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174097", "l": "Association of Emi1 with Cdh1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9724685", "l": "IgE binds omalizumab (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14020", "l": "ATP + beta-nicotinamide D-riboside <=> ADP + beta-nicotinamide D-ribonucleotide + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016994", "l": "precorrin-6A reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61976", "l": "glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19468", "l": "NADPH + 2 nitric oxide + 2 O2 <=> H(+) + NADP(+) + 2 nitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12315", "l": "dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2 <=> 2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50943", "l": "L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe) <=> cyclo(L-phenylalanyl-L-leucyl) + H(+) + tRNA(Leu) + tRNA(Phe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43308", "l": "1-hexadecanoyl-sn-glycerol + ATP = 1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849055", "l": "PTK6 binds ARHGAP35 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605591", "l": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64327", "l": "(11Z)-octadecenoyl-CoA + cholesterol <=> cholesteryl (11Z)-octadecenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863727", "l": "STON2 is neddylated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48275", "l": "2-methylhexanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> 2-methylhexenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65559", "l": "globoside GalGb4Cer + H2O <=> an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20757", "l": "(E)-caffeoyl-CoA + D-threo-isocitrate => 2-[(E)-caffeoyl]-D-threo-isocitrate(3-) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26511", "l": "H2O + L-prolinamide => L-proline + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630921", "l": "NFKBIA variant binds NFkB complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854462", "l": "VLDLR binds VLDL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21958", "l": "H(+) + UDP + vitexin 2''-O-beta-D-glucoside => UDP-alpha-D-glucose + vitexin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12432", "l": "L-alanyl-tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine = H(+) + tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-N(6)-(L-alanyl)-L-lysyl-D-alanyl-D-alanine"}, {"i": "EC:2.3.2.10", "l": "\"UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36214", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + H2O <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29250", "l": "3 H(+)(out) + 2 Na(+)(in) <=> 3 H(+)(in) + 2 Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332235", "l": "CBL binds TGFBR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48184", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19546", "l": "H2O + sn-glycerol 3-phosphocholine => glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102557", "l": "protopanaxadiol 6-hydroxylase activity"}, {"i": "MetaCyc:RXN-14978"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0097599", "l": "xylanase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36320", "l": "2 H(+) + 2 NADPH + octadecanoyl-CoA => CoA + 2 NADP(+) + octadecan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65389", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O => a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22487", "l": "H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate <=> GMP + GTP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62999", "l": "(8Z,11Z,14Z)-eicosatrienamide + H2O <=> (8Z,11Z,14Z)-eicosatrienoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38517", "l": "(9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) => 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42661", "l": "NAD(+) + UDP-N-acetyl-alpha-D-glucosamine => H(+) + NADH + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52142", "l": "(DNA)-3'-phosphate + GMP + 2 H(+) => (DNA)-3'-diphospho-5'-guanosine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53067", "l": "2-methoxyestrone + UDP-alpha-D-glucuronate <=> 2-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34927", "l": "H(+) + NADPH + selenodiglutathione = glutathione + glutathioselenol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48420", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) = CMP + ganglioside GM1 (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690023", "l": "NUBPL binds 4Fe-4S (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25581", "l": "alpha-L-fucose => beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692315", "l": "OX40L binds OX40 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396599", "l": "Recruitment of GRB2:SOS to p-5Y-LAT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120299", "l": "peptide histaminyltransferase activity"}, {"i": "RHEA:66564", "l": "histamine + L-glutaminyl-[protein] = 5-histaminyl-L-glutamyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58701", "l": "FADH2-C4alpha-hydroperoxide + NADPH + rifampicin => FADH2 + H(+) + H2O + NADP(+) + rifampicin hemiaminal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31915", "l": "ATP + D-maltose = ADP + alpha-maltose 1-phosphate + H(+)"}, {"i": "EC:2.7.1.175", "l": "\"Maltokinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010487", "l": "thermospermine synthase activity"}, {"i": "MetaCyc:RXN-11190"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-398040", "l": "Gbeta:gamma activation of PLC beta (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55392", "l": "adenosine in mRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine in mRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11662", "l": "a 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388560", "l": "EDNRA,EDNRB bind EDNs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357479", "l": "p-AXL binds PI3K (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29545", "l": "alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981926", "l": "RAC1 and CDC42 activate PAK3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20539", "l": "apo-[ACP] + D-pantetheine 4'-phosphate + H(+) => H2O + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29257", "l": "Ca(2+)(out) + Na(+)(in) => Ca(2+)(in) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61816", "l": "16,17-didehydropregnenolone + UDP-alpha-D-glucose = 16,17-didehydropregnenolone 3-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59955", "l": "2,6-dimethylheptanoyl-CoA + H2O <=> 2,6-dimethylheptanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004691", "l": "cAMP-dependent protein kinase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042768", "l": "ecdysteroid 2-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008678", "l": "2-deoxy-D-gluconate 3-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50649", "l": "2-(2-methylsulfanyl)ethylmalate => 2-(2-methylsulfanyl)ethylmaleate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24732", "l": "aniline + CO2 => anthranilate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30702", "l": "2-oxoglutarate + beta-alanine <=> 3-oxopropanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20297", "l": "an anilide + H2O = a carboxylate + aniline + H(+)"}, {"i": "EC:3.5.1.13", "l": "\"Aryl-acylamidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380586", "l": "loading of Serotonin in synaptic vesicles (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43248", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O = 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662986", "l": "MT2A binds copper (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49205", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,24R-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23656", "l": "2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate = 3-carboxy-cis,cis-muconate + H(+)"}, {"i": "EC:5.5.1.2", "l": "\"3-carboxy-cis,cis-muconate cycloisomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48018", "l": "2-hydroxy-5-methylquinone + H(+) + H2O + NAD(+) + nitrite => 4-methyl-5-nitrocatechol + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54633", "l": "2-oxoglutarate + O2 + tetradecanoyl-CoA => 2-hydroxytetradecanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25210", "l": "H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine => acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660013", "l": "Defective RPIA does not isomerize RU5P to R5P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61423", "l": "(S)-8-oxocitronellyl enol <=> cis-cis-nepetalactol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381537", "l": "PAPP-A2 proteolyzes IGF:IGFBP5:ALS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9032751", "l": "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36307", "l": "(E)-caffeoyl-CoA + H2O = 3,4-dihydroxybenzaldehyde + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2467775", "l": "Autocleavage of ESPL1 (Separase) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165179", "l": "Formation of TSC1:TSC2 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71849", "l": "LDH tetramer reduces PYR to LACT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38692", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165162", "l": "Phosphorylation of TSC2 by PKB (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627089", "l": "CASP9 is phosphorylated at T125 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48491", "l": "all-trans-retinol--[retinol-binding protein] + NAD(+) <=> all-trans-retinal--[retinol-binding protein] + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55581", "l": "ATP + H2O + L-glutamine => AMP + 2 H(+) + N(5)-phospho-L-glutamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-453200", "l": "SYK autophosphorylates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61743", "l": "steviolmonoside + UDP-alpha-D-glucose <=> H(+) + steviolbioside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-517674", "l": "p-S158,221-HuR binds mRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66764", "l": "ATP + folate(in) + H2O = ADP + folate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11906", "l": "2,4-dihydroxypteridine + NH4(+) => 2-amino-4-hydroxypteridine + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-947535", "l": "Cyclisation of GTP to precursor Z (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63656", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70486", "l": "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56421", "l": "apo-[D-alanyl-carrier protein] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[D-alanyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9609921", "l": "SGTA binds Tail-anchored protein (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625101", "l": "FOXO1 and SIN3A:HDAC complex bind GCK gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21828", "l": "H2O + nitrite + 2 oxidized [2Fe-2S]-[ferredoxin] = 2 H(+) + nitrate + 2 reduced [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.7.7.2", "l": "\"Ferredoxin--nitrate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158137", "l": "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34032", "l": "2'-N-acetylparomamine + H2O => acetate + paromamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102921", "l": "mannosylglycerate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47799", "l": "an aralkylamine + H2O + 2 oxidized [azurin] <=> an aromatic aldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19217", "l": "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)"}, {"i": "EC:4.5.1.1", "l": "\"DDT-dehydrochlorinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044685", "l": "tetrahydromethanopterin-dependent serine hydroxymethyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37031", "l": "D-ribonate = 2-dehydro-3-deoxy-D-arabinonate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042835", "l": "BRE binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701507", "l": "PTPN6 dephosphorylates JAK3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47440", "l": "(3S)-hydroxy-(7Z-hexadecenoyl)-CoA + NAD(+) = 3-oxo-(7Z-hexadecenoyl)-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23077", "l": "4-chlorobenzoyl-CoA + chloride + NADP(+) => 2,4-dichlorobenzoyl-CoA + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66473", "l": "(2Z,6E,10E,14E)-geranylfarnesol => 18-episcalar-17(25)-en-19-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641229", "l": "TLE oligomerizes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.57"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60094", "l": "4alpha-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADH => 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2514831", "l": "Fibrillin-1 degradation by MMP14 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16490", "l": "(R)-prunasin + H2O => D-glucose + mandelonitrile"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416683", "l": "SEMA3E binds to PLXND1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63881", "l": "2 [Fe(III)cytochrome c] + H2O + thiocyanate => 2 [Fe(II)cytochrome c] + cyanate + 2 H(+) + sulfur"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606807", "l": "Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12044", "l": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)"}, {"i": "EC:3.1.1.3", "l": "\"Triacylglycerol lipase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811508", "l": "ING2-bound EP300 acetylates TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14526", "l": "A + beta-cyclopiazonate => AH2 + alpha-cyclopiazonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60743", "l": "(S)-(-)-citronellal + H2O + NADP(+) <=> (S)-(-)-citronellate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66714", "l": "4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + stellatate => 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + stellata-2,6,19-triene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167090", "l": "7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39102", "l": "3-oxodecanedioyl-CoA + CoA <=> acetyl-CoA + octanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19877", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)"}, {"i": "EC:2.7.1.67", "l": "\"1-phosphatidylinositol 4-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26097", "l": "(4R)-limonene + H(+) + NADPH + O2 = H2O + limonene 1,2-epoxide + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000016", "l": "lactase activity"}, {"i": "RHEA:10076", "l": "H2O + lactose = D-galactose + D-glucose"}, {"i": "EC:3.2.1.108", "l": "\"Lactase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66615", "l": "N(6)-carboxybiotinyl-L-lysyl-[protein] + propanoyl-CoA <=> methylmalonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202245", "l": "Phosphorylation of TBSMs in LAT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001147", "l": "camalexin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015415", "l": "ATPase-coupled phosphate ion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61430", "l": "cis-trans-nepetalactone + H(+) + NADH => cis-trans-nepetalactol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30046", "l": "fumarate + L-aspartate <=> iminosuccinate + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "57.822806258010957", "identifiers": [{"i": "GO:0016874", "l": "ligase activity"}, {"i": "EC:6.-.-.-", "l": "\"Ligases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34850", "l": "7,8-dihydromonapterin + H(+) + NADPH <=> 5,6,7,8-tetrahydromonapterin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38463", "l": "a 1-acyl-sn-glycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25512", "l": "(2S)-2-amino-4-deoxychorismate + L-glutamate = chorismate + L-glutamine"}, {"i": "EC:2.6.1.86", "l": "\"2-amino-4-deoxychorismate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936380", "l": "Interaction of PIN1 with p-IRF3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854052", "l": "Formation of the SCF-FBXL7 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32912", "l": "sn-glycerol 3-phosphocholine(out) => sn-glycerol 3-phosphocholine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671707", "l": "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3640862", "l": "Tankyrase binds AXIN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4332356", "l": "CAMK2 binds MAP3K7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55873", "l": "anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) => 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426209", "l": "DAG activation of TRPC channels (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638046", "l": "ACY3:Zn2+ dimer hydrolyses mercapturic acids (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693593", "l": "D-loop extension by DNA polymerases (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202307", "l": "Change of PKC theta conformation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30670", "l": "germacra-1(10),4,11(13)-trien-12-ol + H2O + 2 NADP(+) <=> germacra-1(10),4,11(13)-trien-12-oate + 3 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24713", "l": "2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose <=> L-glutamate + UDP-beta-L-threo-pentopyranos-4-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39840", "l": "a 2,3-diacyl-sn-glycerol + an acyl-CoA => a triacyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.218", "l": "\"Morphine 6-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-379464", "l": "COMT transfers Met to DOPAC to form HVA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39220", "l": "3-oxooctacosanyol-CoA + H(+) + NADPH => (3R)-hydroxyoctacosanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57657", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1b => CMP + ganglioside GT1balpha + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "79.682896251205548", "identifiers": [{"i": "GO:0004529", "l": "exodeoxyribonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45355", "l": "9,10-epoxyoctadecanoate + H2O <=> 9,10-dihydroxyoctadecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031926", "l": "pyridoxal phosphate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26467", "l": "a 2-demethylmenaquinone + S-adenosyl-L-methionine => a menaquinone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.14"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050234", "l": "pyrazolylalanine synthase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033988", "l": "bile-acid 7alpha-dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33016", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + H(+) + NADPH + O2 => [(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42947", "l": "cytidine(40) in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine(40) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.182"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59823", "l": "2 ATP <=> adenosine 3'-diphosphate,5'-triphosphate + AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14096", "l": "2-oxoglutarate + L-tryptophan <=> indole-3-pyruvate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51905", "l": "10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate => 10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158795", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13536", "l": "H2O + medicarpin + NADP(+) <=> (3R)-vestitone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59879", "l": "(indol-3-yl)butanoate + ATP + L-cysteine <=> (indol-3-yl)butanoyl-L-cysteine + AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56699", "l": "D-ribulose 5-phosphate + L-tryptophan <=> (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66645", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + trichobrasilenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48570", "l": "(2E,4Z)-2-chloromuconate + 2 H(+) => 3-chlorocatechol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18697", "l": "3-(4-hydroxyphenyl)pyruvate + H(+) = (4-hydroxyphenyl)acetaldehyde + CO2"}, {"i": "EC:4.1.1.80", "l": "\"4-hydroxyphenylpyruvate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32428", "l": "(1R,4S)-isodihydrocarvone + A => (S)-carvone + AH2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062204", "l": "(13S)-vitexifolin A synthase activity"}, {"i": "RHEA:40027", "l": "9alpha-copalyl diphosphate + H2O = (13S)-vitexifolin A + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1474210", "l": "Collagen type III degradation by MMP14 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57132", "l": "L-ascorbate + O2 + tyramine = (2R)-1-(4-hydroxyphenyl)-2-aminoethanol + H2O + L-dehydroascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710353", "l": "GSDMD (1-275) binds cardiolipin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65938", "l": "beta-D-glucose => beta-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021357", "l": "PRKCI phosphorylates ELF3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64599", "l": "a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose <=> an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36062", "l": "A + dihydrourocanate <=> AH2 + urocanate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374669", "l": "L1 binds NRP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.68"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389491", "l": "Two NPFF receptors can bind neuropeptide FF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16412", "l": "1,2-dihydrovomilenine + NADP(+) <=> H(+) + NADPH + vomilenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193636", "l": "p75NTR interacts with the NOGO receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10240", "l": "a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH"}, {"i": "EC:1.3.1.9", "l": "\"Enoyl-[acyl-carrier-protein] reductase (NADH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47961", "l": "H2O + N(tele)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044105", "l": "L-xylulose reductase (NAD+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53862", "l": "dehydrocholate + H(+) + NADPH => 7beta-hydroxy-3,12-dioxo-5beta-cholan-24-oate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59723", "l": "D-maltohexaono-1,5-lactone + H2O <=> D-maltohexaonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59196", "l": "holo-[(phenol)carboxyphthiodiolenone synthase] + icosanoyl-AMP = AMP + H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686359", "l": "SFTPs translocate from extracellular region to clathrin-coated vesicle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25568", "l": "ATP + beta-D-ribosylnicotinate = ADP + H(+) + nicotinate beta-D-ribonucleotide"}, {"i": "EC:2.7.1.173", "l": "\"Nicotinate riboside kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55637", "l": "ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O => AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46281", "l": "2 [Fe(II)-cytochrome b5] + an N-acylsphing-4-enine + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190141", "l": "ALAD binds to Pb2+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678694", "l": "Heparanase 2 (HPSE2) cleaves heparan sulfate from its proteoglycan (plasma membrane) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30009", "l": "ADP + H(+) + L-arabinose(in) + phosphate => ATP + H2O + L-arabinose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44936", "l": "(9Z,12Z,15Z)-octadecatrienoate + ATP + CoA = (9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.16", "l": "\"D-alanine--alanyl-poly(glycerolphosphate) ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044590", "l": "iron-sulfur-molybdenum cofactor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848774", "l": "PTK6 binds DOK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11047", "l": "a haloacetate + H2O <=> a halide anion + glycolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452838", "l": "Expression of NANOG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46213", "l": "H2O + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine => 4-amino-5-aminomethyl-2-methylpyrimidine + formate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40240", "l": "ATP + CoA + dodecanedioate => AMP + diphosphate + dodecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202245", "l": "Phosphorylation of TBSMs in LAT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001962", "l": "alpha-1,3-galactosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052871", "l": "alpha-tocopherol omega-hydroxylase activity"}, {"i": "MetaCyc:RXN-11003"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50741", "l": "H2O + leukotriene C4 => glycine + leukotriene F4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63318", "l": "9-hydroperoxy-(10E,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25233", "l": "N-acetyl-alpha-neuraminate = N-acetyl-beta-neuraminate"}, {"i": "EC:5.1.3.24", "l": "\"N-acetylneuraminate epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944225", "l": "Association of procollagen type XVII (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047948", "l": "glutarate-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-213407", "l": "Disassociation of PLC-gamma1 from SLP-76 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.121", "l": "\"Lys-Lys/Arg-Xaa endopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49495", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate <=> 2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + 2-oxoglutarate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30374", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O <=> (-)-geosmin + acetone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56204", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] = 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004385", "l": "guanylate kinase activity"}, {"i": "MetaCyc:GUANYL-KIN-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.60", "l": "\"Protein geranylgeranyltransferase type II\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437230", "l": "L1-FGFR cis-heterodimerization (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2172433", "l": "Collagen type XIX degradation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8954117", "l": "E2F6:TFDP1 binds EPC1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50659", "l": "3-(2-methylsulfanyl)ethylmalate <=> 2-(2-methylsulfanyl)ethylmaleate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351876", "l": "Caspase-mediated cleavage of occludin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202692", "l": "PIP3 binds to RhoA and activates it (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018594", "l": "MECP2 binds LBR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707586", "l": "FeHM oxidises LDL,HDL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43307", "l": "3'-phosphoadenylyl sulfate + beta-D-Gal-(1<->1')-Cer <=> 1-(3-O-sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102067", "l": "geranylgeranyl diphosphate reductase activity"}, {"i": "RHEA:26229", "l": "3 NADP(+) + phytyl diphosphate = geranylgeranyl diphosphate + 3 H(+) + 3 NADPH"}, {"i": "EC:1.3.1.83", "l": "\"Geranylgeranyl diphosphate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669012", "l": "EDA binds EDAR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54811", "l": "H(+) + L-isoleucine-(+)-7-isojasmonate + NADPH + O2 <=> H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11691", "l": "ATP + L-leucine + tRNA(Leu) <=> AMP + diphosphate + L-leucyl-tRNA(Leu)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420131", "l": "The PACAP receptor binds PACAP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65653", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontanoyl)-sphing-4-enine => a diacylglycerol + N-(32-(9Z,12Z-octadecadienoyloxy)-dotricontanoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50723", "l": "FMNH2 + methanesulfinate + O2 <=> FMN + H(+) + H2O + methanesulfonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187575", "l": "Ubiquitination of phospho-p27/p21 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69074", "l": "Formation of Processive Complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55595", "l": "2 (3R)-hydroxydecanoyl-[ACP] + H2O <=> (3R)-3-[(3R)-3-hydroxydecanoyloxy]decanoate + H(+) + 2 holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52713", "l": "dTMP + H2O => 2-deoxy-D-ribose 5-phosphate + thymine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380780", "l": "Activation of Src (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31187", "l": "(3S)-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33582", "l": "NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate <=> H(+) + NADH + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878056", "l": "RUNX1:CBFB binds EP300 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66768", "l": "ATP + coproporphyrin I(in) + H2O = ADP + coproporphyrin I(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691167", "l": "CUL1, SKP1, FBXL5 bind (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031402", "l": "sodium ion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9611839", "l": "β3-agonists bind ADRB3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426489", "l": "RISC binds inexactly matching target RNAs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1614591", "l": "Excess cysteine yields lanthionine and H2S (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41881", "l": "(2E)-dodecenoyl-[ACP] + H(+) + NADPH => dodecanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856398", "l": "NPTN binds GABA A receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814831", "l": "TBC1D20 binds RAB1:GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59887", "l": "2-oxoglutarate + chloride + H(+) + L-lysine + O2 <=> 4-chloro-L-lysine + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46222", "l": "3beta-hydroxyandrost-5-en-17-one + H(+) + NADH => androst-5-en-3beta,17beta-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55519", "l": "11-hydroxycucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-oxocucurbitadienol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787403", "l": "GTPBP3 and MTO1 transform uridine-34 yielding 5-taurinomethyluridine-34 in tRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59326", "l": "D-xylono-1,5-lactone + H2O2 => D-xylose + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31036", "l": "arabidiol => (S)-2,3-epoxysqualene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52117", "l": "15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA => 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23352", "l": "2-oxoglutarate + 4-aminobutanoate = L-glutamate + succinate semialdehyde"}, {"i": "EC:2.6.1.19", "l": "\"4-aminobutyrate--2-oxoglutarate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24598", "l": "CoA + H(+) + N(alpha)-acetyl-L-histidine => acetyl-CoA + L-histidine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050087", "l": "mannitol dehydrogenase (cytochrome) activity"}, {"i": "RHEA:17597", "l": "2 [Fe(III)cytochrome c] + D-mannitol = 2 [Fe(II)cytochrome c] + D-fructose + 2 H(+)"}, {"i": "EC:1.1.2.2", "l": "\"Mannitol dehydrogenase (cytochrome)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64243", "l": "glycine + octanoyl-CoA <=> CoA + H(+) + N-octanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-532549", "l": "MPI isomerises Fru6P to Man6P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40327", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54748", "l": "ATP + CoA + firefly L-luciferin = AMP + diphosphate + L-firefly luciferyl-CoA"}, {"i": "EC:6.2.1.52", "l": "\"L-firefly luciferin--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429449", "l": "Syk activation leads to SLP-76 activation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67032", "l": "4,8-dihydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] = 4,5,8-trihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102622", "l": "linuron hydrolase activity"}, {"i": "MetaCyc:RXN-15526"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32281", "l": "(S)-ureidoglycolate + CO2 + 2 NH4(+) => allantoate + 2 H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62400", "l": "(1R,2S)-ephedrine + NAD(+) = (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH"}, {"i": "EC:1.1.1.423", "l": "\"(1R,2S)-ephedrine 1-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050297", "l": "stizolobate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032565", "l": "dGMP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2562564", "l": "Caspase-8 processing within TLR4 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56722", "l": "2 [Fe(II)cytochrome c] + 2 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] => 2 [Fe(III)cytochrome c] + L-cysteinyl-[SoxY protein] + thiosulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805285", "l": "PLK3 phosphorylates TP53 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051373", "l": "FATZ binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34870", "l": "ATP + CoA + thiophene-2-carboxylate <=> AMP + diphosphate + thiophene-2-carbonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688899", "l": "Defective CSF2RA does not bind SFTPs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033754", "l": "indoleamine 2,3-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534388", "l": "Progesterone Activation Of CatSper (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48291", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM3 <=> CMP + ganglioside GD3 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61389", "l": "ATP + biotin(in) + H2O => ADP + biotin(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947538", "l": "Transfer of sulfur from MOCS3-S-S onto MOCS2A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53786", "l": "beta-muricholoyl-CoA + deoxycholate => beta-muricholate + deoxycholoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20554", "l": "(R)-methylmalonyl-CoA => (S)-methylmalonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41197", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H(+) => 1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53246", "l": "cholesta-5,7-dien-3beta,24S-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesta-5,7-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012650", "l": "JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655850", "l": "Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37046", "l": "ATP + H2O + L-alanyl-L-glutamate(out) <=> ADP + H(+) + L-alanyl-L-glutamate(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20111", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ADP => alpha-D-ribose 1,5-bisphosphate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.15", "l": "\"Anhydrosialidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-164840", "l": "ADP and Pi bind to ATPase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9649733", "l": "mature p21 RAS binds GDP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64867", "l": "ITP + oxaloacetate <=> CO2 + IDP + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781941", "l": "WNTs are secreted in exosomes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43703", "l": "(2E,6E)-farnesoate + S-adenosyl-L-methionine <=> methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944218", "l": "Association of procollagen type VIII (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032315", "l": "oxo-DHAs translocate from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-167419", "l": "The receptor:G-protein complex releases GDP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44044", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = 11,12-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44360", "l": "(2S)-2-hydroxy-3,4-dioxopentyl phosphate = 3-hydroxy-2,4-dioxopentyl phosphate"}, {"i": "EC:5.3.1.32", "l": "\"(4S)-4-hydroxy-5-phosphooxypentane-2,3-dione isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58188", "l": "all-trans-lycopene + dimethylallyl diphosphate + H2O = dihydroisopentenyldehydrorhodopin + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65004", "l": "ATP + decanoate + holo-[ACP] = AMP + decanoyl-[ACP] + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005456", "l": "CMP-N-acetylneuraminate transmembrane transporter activity"}, {"i": "REACT:R-HSA-5651942", "l": "Defective SLC35A1 does not exchange CMP-Neu5Ac for CMP (Homo sapiens)"}, {"i": "REACT:R-HSA-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14709", "l": "a 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.7", "l": "\"Cellulose-polysulfatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39267", "l": "(15Z)-3-oxotetracosenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(15Z)-tetracosenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29207", "l": "a menaquinol(in) + dimethyl sulfoxide(out) = a menaquinone(in) + dimethyl sulfide(out) + H2O(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55642", "l": "AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + H(+) => C-terminal L-cysteinyl-[HypE protein] + carbamoyl adenylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-354173", "l": "Activation of Rap1 by cytosolic GEFs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678517", "l": "Defective ABCB11 does not transport bile salts from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64240", "l": "glycine + octanoyl-CoA = CoA + H(+) + N-octanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47906", "l": "ADP + H(+) + N-(acetyl)-sphing-4-enine-1-phosphate => ATP + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050545", "l": "sulfopyruvate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953013", "l": "E2F7 binds E2F8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58855", "l": "(6E)-8-oxogeraniol + NAD(+) <=> (6E)-8-oxogeranial + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29231", "l": "cyanate(in) + H(+)(in) = cyanate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035560", "l": "pheophorbidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.61"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42395", "l": "D-galactose + NAD(+) <=> D-galactono-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45581", "l": "D-galactaro-1,5-lactone => D-galactaro-1,4-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390438", "l": "FAR2 reduces PalmCoA to HXOL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17457", "l": "[sulfur-carrier protein]-L-cysteine + L-cysteine = [sulfur-carrier protein]-S-sulfanyl-L-cysteine + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15419", "l": "CO2 + L-tyrosine + NADPH => L-arogenate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2314566", "l": "GORASP1 phosphorylated by PLK1 and GORASP2 phosphorylated by MAPK3-3/MAPK1 are unable to promote Golgi cisternae stacking (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141159", "l": "TNF-mediated dimerization of procaspase-8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30768", "l": "D-glucurono-3,6-lactone + H2O => D-glucuronate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29314", "l": "FMNH2 + O2 + sulfoacetate <=> FMN + glyoxylate + 2 H(+) + H2O + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981931", "l": "RAC1 and CDC42 activate PAK2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50900", "l": "10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O = (10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52999", "l": "[eIF5A protein]-N-(4-aminobutylidene)-L-lysine + H(+) + NADH <=> [eIF5A protein]-deoxyhypusine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56265", "l": "CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => CMP + H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928607", "l": "p-EPHs bind VAV2,3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31808", "l": "(2E,6E)-farnesyl diphosphate => alpha-guaiene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61080", "l": "(+)-minovincinine + acetyl-CoA = (+)-echitovenine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0038187", "l": "pattern recognition receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013158", "l": "CDC42 GDIs block activation of CDC42 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849908", "l": "SALM4 binds flotillin-1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51940", "l": "(1E,2S)-2-methylbutanal oxime = (1Z,2S)-2-methylbutanal oxime"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47466", "l": "(2E,5Z)-tetradecadienoyl-CoA => (3E,5Z)-tetradecadienoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38524", "l": "1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381727", "l": "RAP1A exchanges GDP for GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198621", "l": "AKT phosphorylates caspase-9 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17345", "l": "(S)-methylmalonyl-CoA + H2O = CoA + H(+) + methylmalonate"}, {"i": "EC:3.1.2.17", "l": "\"(S)-methylmalonyl-CoA hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928627", "l": "EPHB phosphorylates TIAM1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102273", "l": "homophytochelatin synthase (dimmer forming) activity"}, {"i": "MetaCyc:RXN-12529"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53650", "l": "(+)-corvol ether A + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113402", "l": "Formation of DSIF:NELF:early elongation complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0101005", "l": "deubiquitinase activity"}, {"i": "REACT:R-HSA-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654224", "l": "Activated FGFR3 binds PLCG1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64923", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + H2O <=> a 2'-deoxyribonucleoside 5'-phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15068", "l": "H2O + N(4)-benzoylagmatine <=> agmatine + benzoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23289", "l": "acetaldehyde + CoA + NAD(+) => acetyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204798", "l": "Interaction of Tie2 and p85 of PI3K (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8934690", "l": "LIFR gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004598", "l": "peptidylamidoglycolate lyase activity"}, {"i": "RHEA:20924", "l": "a [peptide]-C-terminal (2S)-2-hydroxyglycine = a [peptide]-C-terminal amide + glyoxylate"}, {"i": "EC:4.3.2.5", "l": "\"Peptidylamidoglycolate lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692755", "l": "CDK1 phosphorylates MAPK6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56315", "l": "3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O <=> 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913451", "l": "IL3RB is phosphorylated on Ser-585 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35666", "l": "a 1,2-diacyl-sn-glycerol + H2O <=> a 1-acyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016985", "l": "mannan endo-1,4-beta-mannosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879281", "l": "mycothiol is cleaved to acetylcysteine and glucosaminylinositol (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191072", "l": "Synthesis of Cx43 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450466", "l": "AUF1:mRNA complex is destroyed (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25908", "l": "an alditol + O2 = an aldose + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981606", "l": "Myoglobin binds oxygen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047899", "l": "formate dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009670", "l": "triose-phosphate:phosphate antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5683774", "l": "p-T68-CHEK2 dimerizes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450348", "l": "Activated human JNKs migrate to nucleoplasm (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.158"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451311", "l": "Activation of Ca-permeable Kainate receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26240", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (2E,6E,10E)-geranylgeraniol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34281", "l": "di-trans,cis-polyprenol + H(+) + NADPH => di-trans,poly-cis-dolichol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65769", "l": "a 1,1-dimethyl-3-phenylurea + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23346", "l": "a purine nucleobase + D-ribose => a purine D-ribonucleoside + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938815", "l": "RNF152 polyubiquitinates RRAGA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65877", "l": "5alpha-androst-1-ene-3,17-dione + H2O => 1-hydroxy-5alpha-androstan-3,17-dione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48200", "l": "H(+) + oxidized [electron-transfer flavoprotein] + undecanoyl-CoA = reduced [electron-transfer flavoprotein] + trans-2-undecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647632", "l": "CASP3 cleaves GSDME (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48284", "l": "globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose = globoside NOR1 (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018500", "l": "trans-9R,10R-dihydrodiolphenanthrene dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36209", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21680", "l": "(2S)-2-hydroxyphytanate + O2 = 2-oxophytanate + H2O2"}, {"i": "EC:1.1.3.27", "l": "\"Hydroxyphytanate oxidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050358", "l": "tropinone reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019142", "l": "2-hydroxyglutarate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52524", "l": "O2 + prostaglandin A1 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy prostaglandin A1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-449117", "l": "TXLNA (IL14) binds syntaxin1A (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169398", "l": "ISGylation of host protein filamin B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42706", "l": "H2O + S-(hercyn-2-yl)-L-cysteine S-oxide => hercynine + L-cysteine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62482", "l": "2-glutaroyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42725", "l": "guanosine(2922) in 27S pre-rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(2922) in 27S pre-rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211874", "l": "CYP2S1 4-hydroxylates atRA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350604", "l": "Agmatine + H2O <=> putrescine + urea (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51532", "l": "H(+) + NADPH + O2 + urate = 5-hydroxyisourate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54841", "l": "H(+) + NADPH + O2 + octan-3-one => H2O + NADP(+) + pentyl propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017018", "l": "myosin phosphatase activity"}, {"i": "REACT:R-HSA-390593", "l": "ATP Hydrolysis By Myosin (Homo sapiens)"}, {"i": "REACT:R-HSA-445699", "l": "ATP Hydrolysis By Myosin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42623", "l": "(Z)-2-methylureidoacrylate + H(+) + H2O <=> (Z)-2-methylaminoacrylate + CO2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5226999", "l": "ADD1:ADD3 binds DMTN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1008200", "l": "NFE2 binds the beta globin locus control region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59873", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65319", "l": "2-oxoglutarate + chrodrimanin H + O2 <=> chrodrimanin E + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16522", "l": "H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => NADH + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41391", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57790", "l": "4-nitrocatechol + H(+) + NAD(+) + nitrite => 1,3-dinitrobenzene + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32096", "l": "acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose => CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.70"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781009", "l": "NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296043", "l": "Activation of HCN channels (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18524", "l": "licodione + S-adenosyl-L-methionine <=> 2'-O-methyllicodione + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811454", "l": "MAPKs phosphorylate PP2A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174916", "l": "Formation of N-glucuronides (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58017", "l": "8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56041", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3) => beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)"}]}
{"type": "biolink:MolecularActivity", "ic": "73.539748874002555", "identifiers": [{"i": "GO:0008276", "l": "protein methyltransferase activity"}, {"i": "REACT:R-HSA-9632182", "l": "PRMT1 methylates ESRs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49057", "l": "asperlicin C + H(+) + NADPH + O2 => asperlicin E + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23415", "l": "H2O + N-acetylputrescine <=> acetate + putrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38717", "l": "ADP + choline(in) + H(+) + phosphate => ATP + choline(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54279", "l": "2-oxoglutarate + L-aspartyl-[protein] + O2 <=> (3S)-3-hydroxy-L-aspartyl-[protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851919", "l": "Activated MET binds GAB1 and GRB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202726", "l": "F11R dimerises (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25838", "l": "5-deoxy-D-glucuronate + H(+) => 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60749", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-pyrethrolone => CoA + pyrethrin II"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28121", "l": "di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose <=> D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10607", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937075", "l": "Phosphorylated TAK1 leaves activated TLR receptor complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0000993", "l": "RNA polymerase II complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52773", "l": "7,8-dihydroneopterin 3'-triphosphate => 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72127", "l": "Formation of the Spliceosomal B Complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20469", "l": "H2O + IMP = D-ribose 5-phosphate + hypoxanthine"}, {"i": "EC:3.2.2.12", "l": "\"Inosinate nucleosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875531", "l": "MET binds TNS4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296309", "l": "HCAR3 binds HCAR3 ligands (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372529", "l": "Release of acetylcholine at the synapse (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59847", "l": "(+)-dehydrodiconiferyl alcohol + H(+) + NADPH <=> (R)-isodihydrodehydrodiconiferyl alcohol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40685", "l": "1-O-dodecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + dodecan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605723", "l": "Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928597", "l": "EPH:EFN dimers tetramerise (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21870", "l": "5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+) => 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034540", "l": "3-monobromobisphenol A reductive dehalogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2314686", "l": "Aspirin acetylates PTGS2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18489", "l": "cyanate + H(+) + hydrogencarbonate = carbamate + CO2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019964", "l": "interferon-gamma binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37019", "l": "A + D-serine + H2O = 3-hydroxypyruvate + AH2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-517705", "l": "p-S318,221-HuR binds mRNA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110307", "l": "REV1 binds AP-dsDNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043880", "l": "crotonyl-CoA reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928604", "l": "SFKs phosphorylate VAV2,3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36041", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADH => 2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60213", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65441", "l": "a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidyl-adenosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidyl-adenosine in mRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12382", "l": "L-alanine + L-aspartate 4-semialdehyde => L-2,4-diaminobutanoate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3769394", "l": "AKT phosphorylates CBY1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043819", "l": "precorrin-6A synthase (deacetylating) activity"}, {"i": "RHEA:18261", "l": "H2O + precorrin-5 + S-adenosyl-L-methionine = acetate + 2 H(+) + precorrin-6A + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.152", "l": "\"Precorrin-6A synthase (deacetylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196753", "l": "2xPPCS ligates PPanK with Cys (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28286", "l": "a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022399", "l": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977071", "l": "Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26474", "l": "beta-D-galactosyl-(1->4)-L-rhamnose + phosphate = alpha-D-galactose 1-phosphate + L-rhamnopyranose"}, {"i": "EC:2.4.1.247", "l": "\"Beta-D-galactosyl-(1->4)-L-rhamnose phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202325", "l": "Recruitment of Gads to LAT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209112", "l": "Inhibition of SGG results in the dephosphorylation of the 'destruction complex' by PP2A and release of ARM (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213200", "l": "Release of endostatin-like peptides (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53797", "l": "deoxycholoyl-CoA + ursodeoxycholate => deoxycholate + ursodeoxycholoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43565", "l": "4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + L-alanine => [5-(aminomethyl)-3-furyl]methyl phosphate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801666", "l": "PLK2 phosphorylates CENPJ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047614", "l": "aconitate delta-isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44208", "l": "12-methyltridecanoate + ATP + CoA = 12-methyltridecanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32294", "l": "phosphoethanolamine + 3 S-adenosyl-L-methionine <=> 3 H(+) + phosphocholine + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018807", "l": "RAC3 GDIs block activation of RAC3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34829", "l": "H2O + N-acyl-4-hydroxy-15-methylhexadecasphinganine + NADP(+) => H(+) + N-acyl-15-methylhexadecasphinganine + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26114", "l": "UDP-N-acetyl-alpha-D-glucosamine <=> H2O + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047783", "l": "corticosterone 18-monooxygenase activity"}, {"i": "RHEA:11872", "l": "corticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 18-hydroxycorticosterone + H2O + 2 oxidized [adrenodoxin]"}, {"i": "EC:1.14.15.5", "l": "\"Corticosterone 18-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5629189", "l": "TP53 stimulates expression of SESN1,2,3 genes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.155"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696457", "l": "BDH2 dehydrogenates 3HBA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39440", "l": "(3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA => (2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18056", "l": "H2O + paraoxon <=> 4-nitrophenol + diethylphosphate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63990", "l": "2-thiocytidine 5'-phosphate + ADP + H(+) => 2-thiocytidine + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050450", "l": "citrate (Re)-synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928656", "l": "gamma-secretase cleaves EPHB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70482", "l": "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65291", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62539", "l": "2 [Fe(II)cytochrome c] + digoxigenin + 3 H(+) <=> 2 [Fe(III)cytochrome c] + dihydrodigoxigenin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102825", "l": "quercetin 3-O-rhamnoside-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-8268"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42445", "l": "L-aspartate + NADP(+) => H(+) + iminosuccinate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20961", "l": "1D-myo-inositol hexakisphosphate + H2O => 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5333678", "l": "CPNEs bind PL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20603", "l": "H(+) + NADH + S-formylmycothiol => formaldehyde + mycothiol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4332363", "l": "Autophosphorylation and activation of CAMK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15873", "l": "[(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+)"}, {"i": "EC:2.4.1.242", "l": "\"NDP-glucose--starch glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31289", "l": "acryloyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11945", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + 2 H2O => 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + 2 chloride + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48650", "l": "20-hydroxy-lipoxin A4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lipoxin A4 + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27582", "l": "2-(hydroxymethyl)glutarate = 2-methyleneglutarate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791064", "l": "Expression of ARFGAP1 (GAP) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31230", "l": "di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine <=> di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201637", "l": "Caspase-mediated cleavage of plectin-1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38272", "l": "(3S)-citramalyl-CoA => 3-methylfumaryl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54760", "l": "ATP + H(+) + pyridinium-3,5-dicarboxylate mononucleotide = 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56009", "l": "4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) => 4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35000", "l": "ADP(in) + ATP(out) => ADP(out) + ATP(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388503", "l": "Oxytocin receptor bind oxytocin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004418", "l": "hydroxymethylbilane synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733973", "l": "Bile salts bind FABP6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30775", "l": "H2O + O2 + pyridoxamine = H2O2 + NH4(+) + pyridoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31844", "l": "2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA => 2-oxepin-2(3H)-ylideneacetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29363", "l": "dCMP + H2O = 2'-deoxycytidine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950583", "l": "STAT3 binds to p-Y-IL23R in IL23:IL23 receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102596", "l": "cytochrome P450 dependent ent-sandaracopimaradiene 3-hydroxylase activity"}, {"i": "RHEA:41464", "l": "ent-sandaracopimara-8(14),15-diene + O2 + reduced [NADPH--hemoprotein reductase] = ent-sandaracopimaradien-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.70", "l": "\"Ent-sandaracopimaradiene 3-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362522", "l": "ALDHs oxidise atRAL to atRA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867135", "l": "CEACAM1,3,5,6 bind opa proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102863", "l": "1-18:3-2-18:1-phosphatidylcholine desaturase activity"}, {"i": "MetaCyc:RXN-8330"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21222", "l": "4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+) => L-dopa + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59619", "l": "beta-alanyl-L-arginine + H2O <=> beta-alanine + L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69173", "l": "Joining of adjacent Okazaki fragments (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675473", "l": "SH2B binds JAK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634430", "l": "IL6R gene expression is enhanced by CEBPA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37942", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> (8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14326", "l": "7,8-dihydroxycoumarin + UDP-alpha-D-glucose => daphnin + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55281", "l": "13-cis-retinol + tetradecanoyl-CoA => 13-cis-retinyl tetradecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706315", "l": "Active FLT3 binds to SH2B3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13170", "l": "maleate => fumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51533", "l": "H(+) + NADPH + O2 + urate => 5-hydroxyisourate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874718", "l": "TTPA binds alpha-TOH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847635", "l": "Formation of cis-SNARE complex and membrane fusion in intra-Golgi retrograde traffic (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23007", "l": "a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine <=> a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47535", "l": "chenodeoxycholate + NAD(+) <=> 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047860", "l": "diiodophenylpyruvate reductase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106283", "l": "ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity"}, {"i": "RHEA:42028", "l": "NAD(+) + ursodeoxycholate = 7-oxolithocholate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31207", "l": "FAD + H(+) + hexanoyl-CoA = (2E)-hexenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33074", "l": "D-glucose 6-phosphate <=> 2-deoxy-L-scyllo-inosose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34330", "l": "4-nitrophenol + H(+) + NADPH + O2 <=> 1,4-benzoquinone + H2O + NADP(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090490", "l": "L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36607", "l": "2-oxoglutarate + L-arginine + O2 = (2S,3S)-hydroxyarginine + CO2 + succinate"}, {"i": "EC:1.14.11.41", "l": "\"L-arginine hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696356", "l": "OSCAR binds collagen and SP-D (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912734", "l": "CBL:CRKL binds RAPGEF1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047564", "l": "3-hydroxycyclohexanone dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25520", "l": "an acyl-CoA + pseudotropine = CoA + H(+) + O-acylpseudotropine"}, {"i": "EC:2.3.1.186", "l": "\"Pseudotropine acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665767", "l": "Activated FMNL3 binds G-actin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000704", "l": "pyrimidine dimer DNA N-glycosylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57991", "l": "(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose <=> (20S)-ginsenoside F2 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61328", "l": "O2 + parthenolide + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxyparthenolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12264", "l": "2',4,4',6'-tetrahydroxychalcone + H(+) + O2 = aureusidin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12580", "l": "H2O + NAD(+) + tauropine = H(+) + NADH + pyruvate + taurine"}, {"i": "EC:1.5.1.23", "l": "\"Tauropine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66104", "l": "3-(4-hydroxyphenyl)pyruvate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43160", "l": "adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.223", "l": "\"tRNA(1)(Val) (adenine(37)-N(6))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56770", "l": "2 A + all-trans-adonixanthin + 3 H2O => 2 AH2 + all-trans-zeaxanthin + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34557", "l": "a 2-oxocarboxylate + H(+) + NADH => a (2S)-2-hydroxycarboxylate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004865", "l": "protein serine/threonine phosphatase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35340", "l": "3-hydroxyicosanoyl-CoA + NADP(+) => 3-oxoeicosanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69005", "l": "Cdc6 protein is phosphorylated by CDK (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34622", "l": "1-deoxypentalenate + 2-oxoglutarate + O2 <=> 1-deoxy-11beta-hydroxypentalenate + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801675", "l": "PLK2 phosphorylates NPM1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710101", "l": "CASP4, CASP5 cleave GSDMD (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26203", "l": "ammelide + NH4(+) => ammeline + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49528", "l": "(ethylene terephthalate)(n) + H2O = (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)"}, {"i": "EC:3.1.1.101", "l": "\"Poly(ethylene terephthalate) hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58257", "l": "H2O + O-(ADP-D-ribosyl)-L-seryl-[protein] => ADP-D-ribose + L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018583", "l": "biphenyl-2,3-diol 1,2-dioxygenase activity"}, {"i": "RHEA:14413", "l": "biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+)"}, {"i": "EC:1.13.11.39", "l": "\"Biphenyl-2,3-diol 1,2-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-997237", "l": "SH2B proteins bind JAK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-606349", "l": "Mis18 complex binds the centromere (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.68"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0001594", "l": "trace-amine receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54752", "l": "methanophenazine + reduced coenzyme F420-(gamma-Glu)(n) = dihydromethanophenazine + H(+) + oxidized coenzyme F420-(gamma-Glu)(n)"}, {"i": "EC:1.5.98.3", "l": "\"Coenzyme F420:methanophenazine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29693", "l": "alpha-D-glucose 1-phosphate + alpha-maltotriose => alpha-maltotetraose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18263", "l": "acetate + 2 H(+) + precorrin-6A + S-adenosyl-L-homocysteine => H2O + precorrin-5 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1302698", "l": "PRLR associates with JAK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199050", "l": "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446870", "l": "Polyubiquitinated TRAF6 binds the TAK1 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24707", "l": "(6S)-10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose => (6S)-5,6,7,8-tetrahydrofolate + H(+) + UDP-4-deoxy-4-formamido-beta-L-arabinose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26030", "l": "H2O + N(1)-acetylspermidine + O2 <=> 3-aminopropanal + H2O2 + N-acetylputrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390641", "l": "ADRA1A,B,D bind ADR,NAd (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004740", "l": "pyruvate dehydrogenase (acetyl-transferring) kinase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0004560", "l": "alpha-L-fucosidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050504", "l": "mannosyl-3-phosphoglycerate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48857", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 => (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687107", "l": "MAPK4,6 translocate to nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3149519", "l": "MMACHC decyanates CNCbl (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75856", "l": "Abortive Initiation Before Second Transition (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162657", "l": "Inactivation of Myt1 kinase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10107", "l": "2-oxoglutarate + gibberellin A20 + O2 <=> CO2 + gibberellin A1 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63206", "l": "H(+) + holo-[ACP] + octadecanoate => H2O + octadecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981814", "l": "GalNAc alpha-2,6-sialyltransferase II can add a sialic acid to the T antigen at the alpha 6 position (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30015", "l": "alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose = alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420274", "l": "GIP receptor binds gastric inhibitory peptide (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031433", "l": "telethonin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-419334", "l": "Melatonin receptors can bind melatonin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604368", "l": "Autocatalytic activation of bound proMMP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050114", "l": "myo-inosose-2 dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030331", "l": "estrogen receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66274", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate => a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57946", "l": "CO2 + 2 H2O + heme b => H(+) + H2O2 + harderoheme III"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41232", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170964", "l": "FRS2 binds to active TrkA receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51334", "l": "11-hydroperoxy-(8Z,12E,14Z)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24483", "l": "a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O <=> a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357479", "l": "p-AXL binds PI3K (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31673", "l": "dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine => dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51536", "l": "L-tyrosyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-L-tyrosyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10904", "l": "[cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A = AH2 + C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen sulfide"}, {"i": "EC:1.3.99.36", "l": "\"Cypemycin cysteine dehydrogenase (decarboxylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9619355", "l": "CaMKK autophosphorylates in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382055", "l": "Grb7 binds to the active PDGF receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52111", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA <=> 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050024", "l": "L-galactonolactone oxidase activity"}, {"i": "KEGG.REACTION:R00643"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013110", "l": "RHOC binds effectors at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622420", "l": "NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852324", "l": "GTSE1 binds PLK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866277", "l": "AP-2 directly binds some endocytic cargo (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9733969", "l": "Bile salts dissociate from FABP6 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23379", "l": "L-threonate + NAD(+) <=> 3-dehydro-D-erythronate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.28", "l": "\"Aromatic-L-amino-acid decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2530565", "l": "iC3b proteolysis (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63342", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + ADP + H(+) + phosphate => ATP + L-amino acyl-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31434", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-beta-santalene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41248", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 9R-hydroperoxy(5Z,7E,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102310", "l": "dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate 3-ketoreductase (dTDP-4-dehydro-2,6-dideoxy-alpha-D-allose-forming) activity"}, {"i": "MetaCyc:RXN-12940"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51402", "l": "CoA + H(+) + N-octadecanoyl-serotonin => octadecanoyl-CoA + serotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58351", "l": "2 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698927", "l": "Assembly of the HCMV Genome DNA Replication Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-453183", "l": "p-Y348-SYK dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55902", "l": "6-chloro-L-tryptophan + FAD + 2 H2O => chloride + FADH2 + L-tryptophan + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786050", "l": "IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607751", "l": "TRAF6 oligomerizes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805276", "l": "CDK5 phosphorylates TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34807", "l": "(R)-dihydrocamalexate + O2 + reduced [NADPH--hemoprotein reductase] = camalexin + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48044", "l": "ganglioside GM1 (d18:1(4E)/18:0) + H2O = D-galactose + ganglioside GM2 (d18:1(4E)/18:0)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141316", "l": "TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20962", "l": "1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate => 1D-myo-inositol hexakisphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177937", "l": "Phosphorylation of EGFR by SRC kinase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633441", "l": "TP53 stimulates transcription of TNFRSF10A, TNFRSF10B,TNFRSF10C and TNFRSF10D genes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912369", "l": "NOTCH precursor cleaved to form mature NOTCH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44156", "l": "1D-myo-inositol 5-phosphate + H2O = myo-inositol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43486", "l": "1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432946", "l": "PARVB/Affixin interacts with alpha PIX (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40656", "l": "(R)-malate + succinyl-CoA => (R)-malyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43843", "l": "26-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (3beta)-hydroxy-cholest-5-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805479", "l": "TP53RK phosphorylates TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.18", "l": "\"ATP deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37021", "l": "3-hydroxypyruvate + AH2 + NH4(+) => A + D-serine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48807", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0047486", "l": "chondroitin ABC lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675431", "l": "PP2A dephosphorylates RAF1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36740", "l": "heptadecasphing-4-enine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-heptadecasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20277", "l": "acetyl-CoA + an N-hydroxyarylamine = an N-acetoxyarylamine + CoA"}, {"i": "EC:2.3.1.118", "l": "\"N-hydroxyarylamine O-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39066", "l": "NADP(+) + scyllo-inositol <=> H(+) + NADPH + scyllo-inosose"}]}
{"type": "biolink:MolecularActivity", "ic": "54.533954940254525", "identifiers": [{"i": "GO:0140096", "l": "catalytic activity, acting on a protein"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.24"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14390", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18951", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha,13alpha-diol => O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75891", "l": "Abortive Initiation After Second Transition (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102076", "l": "beta,beta-carotene-9',10'-cleaving oxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534359", "l": "CatSper Channel Mediated Calcium Transport (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16868", "l": "choloyl-CoA + propanoyl-CoA <=> 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22340", "l": "3-hydroxybenzyl alcohol + NADP(+) = 3-hydroxybenzaldehyde + H(+) + NADPH"}, {"i": "EC:1.1.1.97", "l": "\"3-hydroxybenzyl-alcohol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247843", "l": "secretion of WNT ligands (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351913", "l": "Caspase-mediated cleavage of TJP1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210439", "l": "glutamate uptake by astrocytes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050625", "l": "2-hydroxy-1,4-benzoquinone reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1008200", "l": "NFE2 binds the beta globin locus control region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57050", "l": "2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase] => AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-442749", "l": "CaMKK autophosphorylates in the nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193774", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35595", "l": "benzene-1,2,4-triol + O2 = 2 H(+) + maleylacetate"}, {"i": "EC:1.13.11.37", "l": "\"Hydroxyquinol 1,2-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0052743", "l": "inositol tetrakisphosphate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26391", "l": "all-trans-10'-apo-beta-carotenal + beta-ionone => all-trans-beta-carotene + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28685", "l": "iminosuccinate + ubiquinol-8 => L-aspartate + ubiquinone-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202604", "l": "Formation of a heteromeric BMP receptor complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199425", "l": "PHLPP dephosphorylates S473 in AKT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043957", "l": "acryloyl-CoA reductase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40944", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56941", "l": "S-methyl-5-thio-D-ribulose 1-phosphate => 2-(methylsulfanyl)acetaldehyde + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43963", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA <=> a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29131", "l": "menaquinol-8 + nitrate = H2O + menaquinone-8 + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15001", "l": "keto-L-sorbose + NADP(+) = 5-dehydro-D-fructose + H(+) + NADPH"}, {"i": "EC:1.1.1.123", "l": "\"Sorbose 5-dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64625", "l": "(2E)-geraniol + acetyl-CoA => (2E)-geranyl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52531", "l": "2-oxoglutarate + L-asparagine <=> 2-oxosuccinamate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60433", "l": "A + cannabigerolate => AH2 + cannabichromenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912353", "l": "Glucosylation of Pre-NOTCH by POGLUT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120086", "l": "(3S)-(+)-asterisca-2(9),6-diene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "78.423603998002051", "identifiers": [{"i": "GO:0140326", "l": "ATPase-coupled intramembrane lipid transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36501", "l": "2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH => 2-dehydro-3-deoxy-L-rhamnonate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0070037", "l": "rRNA (pseudouridine) methyltransferase activity"}, {"i": "REACT:R-HSA-6790906", "l": "EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12977", "l": "H2O + N-phosphocreatine = creatine + phosphate"}, {"i": "EC:3.9.1.1", "l": "\"Phosphoamidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31769", "l": "L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => 2-oxoglutarate + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29993", "l": "H(+)(out) + L-lyxose(out) => H(+)(in) + L-lyxose(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54304", "l": "n 3'-phosphoadenylyl sulfate + dermatan 4'-sulfate = n adenosine 3',5'-bisphosphate + dermatan 4',6'-disulfate + n H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917693", "l": "ESCRT Disassembly (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.1.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54861", "l": "(2E)-geranial + H(+) + NADPH + O2 => (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70479", "l": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800298", "l": "HGF dimer binds MET (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140670", "l": "ATP-dependent cohesin unloading activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198714", "l": "ERK5 translocates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047465", "l": "N-acylglucosamine-6-phosphate 2-epimerase activity"}, {"i": "MetaCyc:5.1.3.9-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51546", "l": "D-xylulose => D-ribulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49042", "l": "(-)-yatein + H(+) + S-adenosyl-L-homocysteine => (-)-5'-demethylyatein + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31282", "l": "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate <=> (2Z,6E,10E)-geranylgeranyl diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205238", "l": "SHP2 interacts with p-KIT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47616", "l": "ethionamide + H(+) + NADPH + O2 = ethionamide S-oxide + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9670101", "l": "ATRX:DAXX binds to subtelomeric chromosomal regions (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17162", "l": "2,6-dioxo-6-phenylhexa-3-enoate + H2O => 2-oxopent-4-enoate + benzoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1235070", "l": "Expression of Erythropoietin (EPO) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8850945", "l": "Casein kinase II phosphorylates PTEN (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607746", "l": "PKC-delta is activated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57739", "l": "A + all-trans-3,4-didehydro-13,14-dihydroretinol <=> AH2 + all-trans-3,4-didehydroretinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047596", "l": "6-methylsalicylate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141439", "l": "Release of activated MAD2 from kinetochores (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69685", "l": "CHEK2 phosphorylates TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63506", "l": "13-dihydrodaunorubicin + NADP(+) => daunorubicin + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61921", "l": "(2R,4S)-ketoconazole(in) + ATP + H2O => (2R,4S)-ketoconazole(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57445", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O => C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60754", "l": "CoA + jasmolin I => (1R,3R)-chrysanthemoyl-CoA + (Z,S)-jasmololone"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016041", "l": "glutamate synthase (ferredoxin) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.169"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4332236", "l": "CBL neddylates TGFBR2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5620975", "l": "MLKL binds PIPs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5631941", "l": "SESN1,2,3 bind AMPK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9733545", "l": "Bile salts and acids bind ALB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693250", "l": "RHOD binds effectors at the Golgi membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670412", "l": "Phosphorylation of STATs downstream of KIT mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47744", "l": "demethylphylloquinone + H(+) + NADPH = demethylphylloquinol + NADP(+)"}, {"i": "EC:1.6.5.12", "l": "\"Demethylphylloquinone reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177920", "l": "Binding of GRB2 to GAB1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47762", "l": "a 2'-O-methyluridine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine => a uridine in 21S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52656", "l": "a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+) = a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH"}, {"i": "EC:1.1.1.211", "l": "\"Long-chain-3-hydroxyacyl-CoA dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27771", "l": "3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32308", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => H2O + leukotriene A4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29984", "l": "cytidine(in) + H(+)(in) => cytidine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17976", "l": "diphosphate + IMP <=> 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59657", "l": "D-cellotriose + O2 => D-cellotriono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183051", "l": "CBL ubiquitinates Sprouty (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161948", "l": "Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27759", "l": "(6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + CO2 + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183051", "l": "CBL ubiquitinates Sprouty (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65039", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15694", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + AH2 => (R)-2-hydroxy-(9Z,12Z,15Z)-octadecatrienoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592240", "l": "Formation of NRF2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097100", "l": "supercoiled DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610735", "l": "NUMB binds ITCH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140444", "l": "cytoskeleton-nuclear membrane anchor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318571", "l": "Defective MMADHC does not bind MMACHC:B12r (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788999", "l": "HV1-mediated H+ transfer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59331", "l": "D-xylono-1,5-lactone + H2O <=> D-xylonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59283", "l": "L-asparagine <=> D-asparagine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451152", "l": "MAP kinase p38 phosphorylates KSRP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60234", "l": "CO2 + formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692749", "l": "CDC14A,B bind MAPK6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38099", "l": "a ribonucleoside 5'-triphosphate + phytyl phosphate = a ribonucleoside 5'-diphosphate + phytyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16515", "l": "acetate + CO2 + H2O => (S)-lactate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31172", "l": "(3S)-hydroxytetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43711", "l": "ATP + H(+) + hexadecanoate <=> diphosphate + hexadecanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49494", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + 2-oxoglutarate + H(+) + H2O => GDP-4-dehydro-alpha-D-rhamnose + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21646", "l": "ADP + H(+) + sn-glycerol 3-phosphate => ATP + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1912357", "l": "ITCH ubiquitinates DTX (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63916", "l": "5-fluorouridine + ATP = 5-fluorouridine 5'-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56452", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = 12-epi-hapalindole U"}, {"i": "EC:5.5.1.32", "l": "\"12-epi-hapalindole U synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45772", "l": "[(1->4)-beta-D-mannosyl](n) + phosphate = [(1->4)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate"}, {"i": "EC:2.4.1.319", "l": "\"Beta-1,4-mannooligosaccharide phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624800", "l": "CDK1 phosphorylates LBR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015213", "l": "uridine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33194", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018768", "l": "RHOU auto-activates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47858", "l": "ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate => ganglioside GD1a (d18:1(4E)) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8871266", "l": "YAP1 binds TEAD3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9676160", "l": "AAMP binds NOD2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44248", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418858", "l": "RhoGTPase GEF's recruited to DCC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8940959", "l": "Neurolysin degrades neurotensin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018756", "l": "RHOH binds GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043870", "l": "N-acetyl-gamma-aminoadipyl-phosphate reductase activity"}, {"i": "RHEA:41948", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH"}, {"i": "MetaCyc:RXN-5183"}, {"i": "EC:1.2.1.103", "l": "\"[Amino-group carrier protein]-6-phospho-L-2-aminoadipate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12118", "l": "AH2 => A + H2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202443", "l": "Oligomerization of CARMA1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975594", "l": "PLB1 hydrolyses RPALM to atROL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33353", "l": "CoA + H(+) + N-hexacosanoylsphinganine => hexacosanoyl-CoA + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64766", "l": "2-aminoprop-2-enoate + 3-methyl-3-sulfanylhexan-1-ol => S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25421", "l": "3-hydroxybenzoyl-CoA + AH2 + 2 ATP + 2 H2O => 3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA + A + 2 ADP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56645", "l": "a uridine in mRNA => a pseudouridine in mRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804194", "l": "PRDM1 binds the TP53 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956659", "l": "ABL1 phosphorylates YAP1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295613", "l": "SPRY2 binds GRB2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35385", "l": "CO2 + H(+) + precorrin-7 + S-adenosyl-L-homocysteine => precorrin-6B + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625424", "l": "The retrograde IFT train dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8864595", "l": "TFAP2B homodimer binds YEATS4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38901", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in) => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871366", "l": "p-Y281,292-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66288", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-D-mannosyl-alpha-1->6-inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39233", "l": "(3R)-hydroxytriacontanoyl-CoA + NADP(+) => 3-oxo-triacontanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848864", "l": "PTK6 binds ARAP1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211164", "l": "AKT phosphorylates FOXO1A (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13681", "l": "a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.37", "l": "\"DNA (cytosine-5-)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40797", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49983", "l": "H2O + hexanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23088", "l": "ATP + O-alkylglycerone = 1-O-alkylglycerone 3-phosphate + ADP + H(+)"}, {"i": "EC:2.7.1.84", "l": "\"Alkylglycerone kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47233", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39847", "l": "a 2-acylglycerol + ATP = a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448603", "l": "IL33:IL1RL1 binds IL1RAP-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428273", "l": "SPHK1 phosphorylates SPG to S1P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41657", "l": "dihydrosanguinarine + NADP(+) => NADPH + sanguinarine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30430", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-germacrene D + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22015", "l": "precorrin-4 + S-adenosyl-L-methionine <=> precorrin-5 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42739", "l": "guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5695980", "l": "ACAD10 dehydrogenates S-2MPDA-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391152", "l": "p-4Y-SIRPA:CD47 binds PTK2B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419334", "l": "Melatonin receptors can bind melatonin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102764", "l": "6-deoxotyphasterol C-23 hydroxylase activity"}, {"i": "MetaCyc:RXN-777"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60413", "l": "H2O + monoglucosyl-enterobactin => [N-(2,3-dihydroxybenzoyl)-L-seryl]2-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-442749", "l": "CaMKK autophosphorylates in the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35773", "l": "3-amino-5-hydroxybenzoate + H(+) + H2O => 5-deoxy-5-amino-3-dehydroshikimate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798528", "l": "S100A8:S100A9 binds Mn2+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202966", "l": "Caspase mediated cleavage of HIP-55 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48221", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tricosanoyl-CoA => (2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66727", "l": "(S)-lactate + L-phenylalanine <=> H2O + N-[(S)-lactoyl]-L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54485", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphocholine => 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668714", "l": "RAC1:GTP binds NOX1 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56447", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617652", "l": "HOXD3 mRNA is translated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66655", "l": "(2E,6E)-farnesyl diphosphate <=> african-1-ene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62612", "l": "adenosine(1832) in 18S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(1832) in 18S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54239", "l": "1,2-didecanoyl-sn-glycerol + CDP-choline <=> 1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54638", "l": "diphosphate + labda-7,13(16),14-triene => (13E)-labda-7,13-dien-15-yl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730884", "l": "Phosphorylation of NTAL by p-SYK/Lyn (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23067", "l": "an alkanesulfonate + FMNH2 + O2 <=> an aldehyde + FMN + 2 H(+) + H2O + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21197", "l": "5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine => L-methionine + tetrahydropteroyltri-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381668", "l": "cAMP activates EPAC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50497", "l": "acetyl-CoA + N-terminal glycyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetylglycyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1640164", "l": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72722", "l": "eIF2 activation (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110218", "l": "Cleavage of uracil by TDG glycosylase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2314686", "l": "Aspirin acetylates PTGS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686709", "l": "Uncoating of SARS-CoV-1 Genome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62204", "l": "1-propanol + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H(+) + propanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10962", "l": "(R)-lactate => (S)-lactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229194", "l": "Depolymerization of lamin filaments after PKC-mediated phosphorylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848751", "l": "PTK6 binds AKT1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76466", "l": "CYP4A11 12-hydroxylates DDCX (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.27", "l": "\"D-galactarolactone cycloisomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34230", "l": "5-nitrosalicylate + O2 <=> 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2247513", "l": "STAB1:ligand is endocytosed (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-606326", "l": "HJURP:CENPA complex localizes to the centromere (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55788", "l": "acetone + H(+) + NADH + O2 = H2O + hydroxyacetone + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848023", "l": "Activated PTK6 binds STAP2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.4", "l": "\"Chloroplast protein-transporting ATPase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22026", "l": "2 H(+) + NADH + trimethylamine N-oxide => H2O + NAD(+) + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043125", "l": "ErbB-3 class receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65644", "l": "(4R)-hydroxysphing-(8E)-enine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8E)-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53597", "l": "1-octadecanoyl-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.-.-", "l": "\"Carbon-sulfur lyases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38211", "l": "hexadecane-1,2-diol + 2 hexadecanoyl-CoA = 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10638", "l": "D-mannuronate + H(+) + NADPH => D-mannonate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482772", "l": "Release of platelet cytosolic components (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.99.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381668", "l": "cAMP activates EPAC1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444691", "l": "Prokineticin receptors bind prokineticin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029273", "l": "PI3K binds to p-6Y-SYK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48236", "l": "2 2-acetylphloroglucinol = 1,3,5-trihydroxybenzene + 2,4-diacetylphloroglucinol + H(+)"}, {"i": "EC:2.3.1.272", "l": "\"2-acetylphloroglucinol acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381668", "l": "cAMP activates EPAC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53628", "l": "(2E,6E)-farnesyl diphosphate = (2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate"}, {"i": "EC:4.2.3.160", "l": "\"(2S,3R,6S,9S)-(-)-protoillud-7-ene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102063", "l": "beta-curcumene synthase activity"}, {"i": "MetaCyc:RXN-10598"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114670", "l": "GPIb-IX-V binds to vWF:Collagen complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60728", "l": "citral + H2O + NADP(+) = 3,7-dimethylocta-2,6-dienoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14583", "l": "2 L-ascorbate + NAD(+) => H(+) + 2 monodehydro-L-ascorbate radical + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617815", "l": "BBSome binds RAB3IP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39739", "l": "3-hydroxydodecanoate + H(+) + NADPH + O2 = 3,12-dihydroxydodecanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34967", "l": "sn-glycerol 3-phosphate(in) = sn-glycerol 3-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051879", "l": "Hsp90 protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40792", "l": "H2O + hexacosanoyl-CoA => CoA + H(+) + hexacosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218812", "l": "FYN phosphorylates PAK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008330", "l": "protein tyrosine/threonine phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428917", "l": "G13 activation by TP receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60609", "l": "1-tetradecanoyl-sn-glycero-3-phosphoethanolamine => 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672961", "l": "PP2A dephosphorylates inactive RAFs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22492", "l": "H2O + N-formimidoyl-L-glutamate = formamide + L-glutamate"}, {"i": "EC:3.5.3.8", "l": "\"Formimidoylglutamase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18541", "l": "10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine = dihydrochelirubine + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.119", "l": "\"10-hydroxydihydrosanguinarine 10-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871226", "l": "RET binds GFRA1,GFRA2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1671691", "l": "PRLR-bound STAT5 is phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63885", "l": "H2O2 + L-tyrosine => H2O + L-dopa"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011077", "l": "LHX2 binds to ROBO2 gene locus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40857", "l": "FADH2 + trans-2-undecenoyl-CoA => FAD + H(+) + undecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139905", "l": "Translocation of activated BAD protein to mitochondria (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694522", "l": "Inner coat assembly and cargo binding (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033906", "l": "hyaluronoglucuronidase activity"}, {"i": "MetaCyc:3.2.1.36-RXN"}, {"i": "EC:3.2.1.36", "l": "\"Hyaluronoglucuronidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38879", "l": "a fatty acid(in) = a fatty acid(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55279", "l": "9-cis-retinol + tetradecanoyl-CoA <=> 9-cis-retinyl tetradecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53927", "l": "a secondary amine + S-adenosyl-L-methionine <=> a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42355", "l": "(R)-nicotine + A + H2O <=> (R)-6-hydroxynicotine + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52119", "l": "15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA <=> 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53570", "l": "18-hydroxy-12,13-epoxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 12,13-epoxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22414", "l": "diphosphate + N-adenylylanthranilate => anthranilate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44673", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O => a 1-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421453", "l": "Mitochondrial uptake and processing of ALAS1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20713", "l": "6-carboxyhexanoyl-CoA + H(+) + L-alanine => (S)-8-amino-7-oxononanoate + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-350598", "l": "Arginine<=>Agmatine+CO2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-398184", "l": "LARG activation by G alpha 12/13 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211968", "l": "CYP2W1 oxidises INDOL (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42948", "l": "cytidine(48) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987039", "l": "JAK1 binds IL20RA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810937", "l": "Lamellar bodies bind the early cornified envelope (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31960", "l": "9beta-pimara-7,15-dien-19-ol + O2 + reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50298", "l": "2-oxo-N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619467", "l": "PPM1F dephosphorylates CAMK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-176175", "l": "Stalling of DNA replication fork and RPA binding (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14619", "l": "CoA-glutathione + H(+) + NADPH => CoA + glutathione + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36762", "l": "N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine <=> alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373745", "l": "SDK1 homophillic interaction (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8873850", "l": "STARD5 binds DCA, LCA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168136", "l": "NOTCH3 binds DLL4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40560", "l": "dTDP-beta-L-evernosamine + NADPH + O2 => dTDP-N-hydroxy-beta-L-evernosamine + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38929", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40757", "l": "1-(9Z,12Z)-octadecadienoylglycerone 3-phosphate + hexadecanoate => (9Z,12Z)-octadecadienoate + 1-hexadecanoylglycerone 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66019", "l": "bromide + H2O2 <=> H2O + hypobromite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013438", "l": "RHOD binds effectors at the endosome membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917730", "l": "Cargo Recognition And Sorting (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114552", "l": "Thrombin-activated PARs activate G12/13 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63893", "l": "ATP + H2O + L-tryptophan => AMP + D-tryptophan + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60504", "l": "1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9010815", "l": "SLITs bind keratan sulfate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-937050", "l": "Pellino ubiquitinates hp-IRAK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14917", "l": "3 O2 + obtusifoliol + 3 reduced [NADPH--hemoprotein reductase] = 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9015111", "l": "Factor Xa inhibitors binds Xa (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214845", "l": "CACT and DL dimer are phosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50878", "l": "a hydroxy polyunsaturated fatty acid + H2O + NADP(+) => a hydroperoxy polyunsaturated fatty acid + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56229", "l": "(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphocholine => (9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45194", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37315", "l": "glycyl-L-glutamine + H2O = glycine + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56426", "l": "(9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine => H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868344", "l": "CDK5:p25 phosphorylates lamin A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32170", "l": "ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine <=> aerobactin + AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10703", "l": "H2O + limonene 1,2-epoxide <=> limonene-1,2-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70272", "l": "PGM:Mg2+ isomerise G6P to G1P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27517", "l": "H2O + sphinganine 1-phosphate <=> phosphate + sphinganine"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004864", "l": "protein phosphatase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497824", "l": "BH4 is oxidised to the BH3 radical during the eNOS catalytic cycle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798474", "l": "S100A8:S100A9 binds Zn2+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693061", "l": "STAMBP binds STAM (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111264", "l": "Addition of nucleotides between position +11 and +30 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35514", "l": "glycyrrhetaldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> glycyrrhetinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1299318", "l": "Activation of TASK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.85", "l": "\"6-phospho-beta-galactosidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106352", "l": "aspartate dehydrogenase NADP activity"}, {"i": "RHEA:11784", "l": "H2O + L-aspartate + NADP(+) = H(+) + NADPH + NH4(+) + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.39"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047643", "l": "alginate synthase activity"}, {"i": "RHEA:46876", "l": "[(1->4)-beta-D-mannuronosyl](n) + GDP-alpha-D-mannuronate = [(1->4)-beta-D-mannuronosyl](n+1) + GDP + H(+)"}, {"i": "EC:2.4.1.33", "l": "\"Mannuronan synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13764", "l": "L-methionine + S-adenosyl-L-methionine <=> S-adenosyl-L-homocysteine + S-methyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25565", "l": "H2O + N-acetyl-4-O-acetylneuraminate => acetate + H(+) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602466", "l": "Activation of MT-MMPs by FURIN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46205", "l": "androst-5-en-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] => androst-5-en-3beta,7alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11583", "l": "a CDP-1,2-diacyl-sn-glycerol + myo-inositol <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56914", "l": "(E)-2-((N-methylformamido) methylene)succinate + 3 H(+) + NADH => (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9734730", "l": "ORC1 translocates to the nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2327746", "l": "FN1 aggregation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610726", "l": "The IFT-A complex recruits TULP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851038", "l": "BTN3A1 binds prenylated phosphoantigens (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56920", "l": "a medium chain fatty acid + ATP + H(+) = a medium-chain fatty acyl-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42627", "l": "(Z)-3-ureidoacrylate + H(+) + H2O <=> (Z)-3-aminoacrylate + CO2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190141", "l": "ALAD binds to Pb2+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034321", "l": "alcohol O-octanoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015467", "l": "G-protein activated inward rectifier potassium channel activity"}, {"i": "REACT:R-HSA-1013020", "l": "Activation of GIRK/Kir3 Channels (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448661", "l": "IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48125", "l": "ganglioside GD3 (d18:1(4E)) + H2O => ganglioside GM3 (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11578", "l": "AMP + H(+) + thiamine diphosphate => ATP + thiamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30336", "l": "CTP + H(+) + H2O => NH4(+) + UTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-573294", "l": "Activated TRAF6 synthesizes free K63 linked pUb chains. (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0039552", "l": "RIG-I binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29470", "l": "H(+)(out) + K(+)(in) <=> H(+)(in) + K(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34671", "l": "3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + S-adenosyl-L-methionine = 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204500", "l": "CyP60 chaperones Basigin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "55.878866893815221", "identifiers": [{"i": "GO:0015318", "l": "inorganic molecular entity transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246696", "l": "APC truncation mutants are not K63 polyubiquitinated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49420", "l": "ATP + valienone = ADP + H(+) + valienone 7-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0000992", "l": "RNA polymerase III cis-regulatory region sequence-specific DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12623", "l": "CO2 + L-alanine => H(+) + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.214", "l": "\"2-dehydropantolactone reductase (Si-specific)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50882", "l": "4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+) => 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800793", "l": "PIDD1 translocates to the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28889", "l": "H(+)(out) + L-serine(out) => H(+)(in) + L-serine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198756", "l": "ERK1/2 phosphorylates MSK1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111930", "l": "Adenylate cyclase produces cAMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19713", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate"}, {"i": "EC:6.2.1.15", "l": "\"Arachidonate--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58266", "l": "an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061798", "l": "GTP 3',8'-cyclase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803761", "l": "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428535", "l": "Activation of RAC1 by SOS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466391", "l": "NRF1:p-PPARGC1A, NRF2 bind the TFAM promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421439", "l": "4 porphobilinogen + H2O => hydroxymethylbilane + 4 NH3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72663", "l": "De novo formation of eIF2:GTP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61101", "l": "(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-dihydrotricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18655", "l": "3-oxo-3-ureidopropanoate => barbiturate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51004", "l": "2 [Fe(III)cytochrome cL] + a primary alcohol = 2 [Fe(II)cytochrome cL] + an aldehyde + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102652", "l": "gibberellin A9,2-oxoglutarate:oxygen oxidoreductase activity"}, {"i": "MetaCyc:RXN-171"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341048", "l": "SUMOylation of RXRA with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209536", "l": "IkB is ubiquitinated and degraded (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35898", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672961", "l": "PP2A dephosphorylates inactive RAFs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070380", "l": "high mobility group box 1 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61190", "l": "H(+) + quercetin 3-O-beta-D-glucoside-7-O-alpha-L-rhamnoside + UDP => quercetin 3-O-beta-D-glucoside + UDP-beta-L-rhamnose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166220", "l": "FA anion diffuses laterally to UCP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482892", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30355", "l": "a quinol + methane + O2 = a quinone + H2O + methanol"}, {"i": "EC:1.14.18.3", "l": "\"Methane monooxygenase (particulate)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375140", "l": "CDO binds promyogenic cadherins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103039", "l": "protein methylthiotransferase activity"}, {"i": "EC:2.8.4.4", "l": "\"[Ribosomal protein S12] (aspartate(89)-C(3))-methylthiotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443780", "l": "Cis-heterodimerization of L1 and DM-GRASP/ALCAM/BEN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678694", "l": "Heparanase 2 (HPSE2) cleaves heparan sulfate from its proteoglycan (plasma membrane) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29788", "l": "ATP + glutathione(in) + H2O => ADP + glutathione(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868071", "l": "Clathrin recruits PIK3C2A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-555065", "l": "Formation of clathrin coated vesicle (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30082", "l": "ATP + CoA + crotonobetaine <=> AMP + crotonobetainyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.105", "l": "\"Rhomboid protease\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61224", "l": "H2O + L-asparagine + O2 = 2-oxosuccinamate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55875", "l": "anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) <=> 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043862", "l": "arginine:agmatine antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50047", "l": "an acyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909552", "l": "Phosphorylation of STAT1 at Ser727 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48439", "l": "H2O + pentanoate ester <=> an aliphatic alcohol + H(+) + pentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701507", "l": "PTPN6 dephosphorylates JAK3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47000", "l": "H(+) + NADH + 2 NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NAD(+) + 2 NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.6.1.4", "l": "\"NAD(P)(+) transhydrogenase (ferredoxin)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28663", "l": "H2O + melibiose = alpha-D-galactose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43742", "l": "AMP + diphosphate + hexanoyl-CoA => ATP + CoA + hexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848829", "l": "CBL autoubiquitinates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46430", "l": "(25R)-4beta,26-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin] => 4beta-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17487", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53419", "l": "8-amino-8-demethylriboflavin + S-adenosyl-L-methionine <=> 8-demethyl-8-(methylamino)riboflavin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983307", "l": "IL15 binds IL15RA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25198", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O => 5-amino-6-(D-ribitylamino)uracil + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451900", "l": "IL2RB binds JAK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24300", "l": "2 cob(I)yrinate a,c diamide + FMN + 3 H(+) = 2 cob(II)yrinate a,c diamide + FMNH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.46"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18476", "l": "1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950716", "l": "IL27RA binds JAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52649", "l": "H2O + L-arabino-1,4-lactone 5-phosphate => 5-phospho-L-arabinonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047702", "l": "beta-lysine 5,6-aminomutase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6783880", "l": "PIPOX oxidises PPCA to P6C (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72143", "l": "Lariat Formation and 5'-Splice Site Cleavage (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45589", "l": "a long-chain fatty acid + ATP + holo-[ACP] => a long-chain fatty acyl-[ACP] + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351948", "l": "Mitochondrial recruitment of Drp1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26500", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP => delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20096", "l": "an anthocyanidin + H(+) + UDP-alpha-D-glucose <=> an anthocyanidin 3-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63298", "l": "H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3-carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'-thioadenosine => an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34573", "l": "H(+) + NADPH + presqualene diphosphate => C30 botryococcene + diphosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57604", "l": "2 [Fe(II)-cytochrome b5] + a 1-tetracosanoyl-2-acyl-phosphoglycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a 1-[(15Z)-tetracos-15-enoyl]-2-acyl-phosphoglycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22691", "l": "D-alanine + H2O + O2 <=> H2O2 + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052897", "l": "N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity"}, {"i": "RHEA:25972", "l": "H2O + N(8)-acetylspermidine + O2 = 4-acetamidobutanal + H2O2 + propane-1,3-diamine"}, {"i": "EC:1.5.3.15", "l": "\"N(8)-acetylspermidine oxidase (propane-1,3-diamine-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106149", "l": "indole-3-carbonyl nitrile 4-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41980", "l": "3alpha-hydroxy-5alpha-pregnan-20-one + NAD(+) = 5alpha-pregnane-3,20-dione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56032", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38964", "l": "ATP + H2O + leukotriene C4(in) => ADP + H(+) + leukotriene C4(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090489", "l": "L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating, decarboxylating)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5688786", "l": "ATXN3 binds RAD23 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28309", "l": "beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose <=> beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11317", "l": "an aliphatic aldoxime => a nitrile + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852324", "l": "GTSE1 binds PLK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2106615", "l": "Removal of siRNA passenger strand (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19516", "l": "carbamoyl phosphate + L-ornithine <=> H(+) + L-citrulline + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018826", "l": "RHOT2 hydrolyzes GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666169", "l": "Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47197", "l": "a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-398040", "l": "Gbeta:gamma activation of PLC beta (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56273", "l": "4 [Fe(III)cytochrome cL] + H2O + methanol => 4 [Fe(II)cytochrome cL] + formate + 5 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30793", "l": "dGDP + H(+) + phosphoenolpyruvate => dGTP + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52997", "l": "[eIF5A protein]-N-(4-aminobutylidene)-L-lysine + H(+) + NADH => [eIF5A protein]-deoxyhypusine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655193", "l": "KIAA0101 double monoubiquitination (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17279", "l": "2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O => 6-phospho-D-gluconate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65928", "l": "3-bromo-2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine = 3-bromo-2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21077", "l": "2'-deoxyuridine + 2-oxoglutarate + O2 => CO2 + succinate + uridine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38104", "l": "L-galactonate => 2-dehydro-3-deoxy-L-galactonate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52325", "l": "2 L-arginine + 4 O2 + 3 reduced [flavodoxin] => 5 H(+) + 4 H2O + 2 L-citrulline + 2 nitric oxide + 3 oxidized [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41223", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27587", "l": "L-tryptophan + pyruvate => indole-3-pyruvate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43848", "l": "[thioredoxin]-dithiol + arsenate + H(+) = [thioredoxin]-disulfide + arsenite + H2O"}, {"i": "EC:1.20.4.4", "l": "\"Arsenate reductase (thioredoxin)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61290", "l": "5-deoxy-alpha-D-ribose 1-phosphate + ADP + H(+) => 5-deoxy-D-ribose + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9688832", "l": "MLKL binds PDCD6IP and SDCBP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-398184", "l": "LARG activation by G alpha 12/13 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18542", "l": "10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine => dihydrochelirubine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39725", "l": "a 1,2-diacyl-sn-glycerol(out) => a 1,2-diacyl-sn-glycerol(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21177", "l": "L-idonate + NADP(+) => 5-dehydro-D-gluconate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42242", "l": "1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29877", "l": "H(+) + L-serine + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31863", "l": "(S)-2,3-epoxysqualene = friedelin"}, {"i": "EC:5.4.99.50", "l": "\"Friedelin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705738", "l": "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928640", "l": "PAKs phosphorylate MLC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10031", "l": "D-glutamate + H2O + O2 <=> 2-oxoglutarate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51815", "l": "ATP(in) + CoA(in) + H(+)(out) + tetradecanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + tetradecanoyl-CoA(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015611", "l": "ABC-type D-ribose transporter activity"}, {"i": "MetaCyc:ABC-28-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32844", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycerol => a 1-acyl-sn-glycero-3-phosphocholine + a triacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35435", "l": "cyanidin 3-O-beta-D-galactoside + UDP-alpha-D-xylose = cyanidin 3-O-[beta-D-xylosyl-(1->2)-beta-D-galactoside] + H(+) + UDP"}, {"i": "EC:2.4.2.50", "l": "\"Cyanidin 3-O-galactoside 2''-O-xylosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53883", "l": "ADP-alpha-D-glucose + D-glucose 6-phosphate <=> ADP + alpha,alpha-trehalose 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191830", "l": "snRNP nuclear import and release (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62918", "l": "an N-terminal trimethyl-L-alpha-aminoacyl-[protein] + 3 H(+) + 3 S-adenosyl-L-homocysteine => an N-terminal L-alpha-aminoacyl-[protein] + 3 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21117", "l": "D-maltose + phosphate => beta-D-glucose 1-phosphate + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661446", "l": "BMG, BDG translocates from ER lumen to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41564", "l": "aklavinone + dTDP-beta-L-rhodosamine = aclacinomycin T + dTDP + 2 H(+)"}, {"i": "EC:2.4.1.326", "l": "\"Aklavinone 7-L-rhodosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627106", "l": "SMAC (DIABLO) forms dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4090281", "l": "PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419083", "l": "Myosin phosphatase inactivation by ROCK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17010", "l": "2-succinylbenzoate + ATP + CoA => 2-succinylbenzoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013990", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28056", "l": "formate + propanoyl-CoA => 2-oxobutanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58924", "l": "(3R,4R)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-4,7-diol = (-)-maackiain + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29756", "l": "(R)-lipoate(in) => (R)-lipoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856223", "l": "B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63592", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990932", "l": "5.8S rRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451377", "l": "Interaction of IQGAP1 with nephrin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1013020", "l": "Activation of GIRK/Kir3 Channels (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61251", "l": "H2O + L-tyrosine + O2 <=> 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35917", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050570", "l": "4-hydroxythreonine-4-phosphate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65675", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontenoyl)-sphing-4-enine <=> a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6813626", "l": "LEAP2 binds bacteria (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797961", "l": "CHDH oxidises Cho to BETALD (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662613", "l": "MT3 exchanges zinc for copper (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5251942", "l": "Hikeshi binds HSP70s:ATP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202713", "l": "CD84 homodimerises (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050057", "l": "linamarin synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29112", "l": "H(+) + NADPH + ubiquinone-8 => NADP(+) + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034885", "l": "gamma-N-formylaminovinylacetate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44431", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + glycerol <=> a 1-acyl-sn-glycero-3-phosphocholine + a 1-acylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13883", "l": "a carboxylate + a quinol + H(+) => a quinone + an aldehyde + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2984226", "l": "PLK1 phosphorylates NEK9 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13910", "l": "phosphate + urate D-ribonucleoside => alpha-D-ribose 1-phosphate + urate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40715", "l": "dihydroxyacetone phosphate + hexadecanoyl-CoA = 1-hexadecanoylglycerone 3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1067659", "l": "Assembly of hexameric IL-6 receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40977", "l": "2 H(+) + 2 hexadecanoate + sn-glycerol 3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22416", "l": "3,4-dihydroxybenzoate + H(+) = catechol + CO2"}, {"i": "EC:4.1.1.63", "l": "\"Protocatechuate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42141", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-(4R)-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647980", "l": "mature RAS proteins translocate to plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72095", "l": "Internal Methylation of mRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31469", "l": "bis(beta-D-glucosyl) crocetin + UDP => beta-D-glucosyl crocetin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37038", "l": "H2O + L-2-aminopentanoate + NAD(+) <=> 2-oxopentanoate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166038", "l": "GPI-bound CD14 binds LPS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-448963", "l": "Interaction of MyoD:E protein with MEF2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30862", "l": "dITP + H2O <=> dIDP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50141", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25829", "l": "AH2 + an N-acyl-(4R)-4-hydroxysphinganine + O2 => A + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427514", "l": "eNoSC deacetylates histone H3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53114", "l": "5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + NADPH => 3alpha-hydroxy-5alpha-androstane 17-O-(beta-D-glucuronate) + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46498", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(out) => N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52345", "l": "(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate => (24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41012", "l": "(+)-sesamin + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n => (+)-sesamin monocatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140567", "l": "transmembrane protein dislocase activity"}, {"i": "RHEA:66168", "l": "[protein]-with a C-terminal TM segment(out) + ATP + H2O = [protein]-with a C-terminal TM segment(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005139", "l": "interleukin-7 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62074", "l": "6-phospho-D-galactono-1,5-lactone + H(+) + NADPH => D-galactose 6-phosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218891", "l": "RIPK1:RIPK3 oligomer binds MLKL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34878", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA + 2 H2O + NADP(+) <=> 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810937", "l": "Lamellar bodies bind the early cornified envelope (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18656", "l": "barbiturate + H2O <=> 3-oxo-3-ureidopropanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2529020", "l": "CK2 phosphorylates condensin I subunits (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043804", "l": "imidazolone hydrolase activity"}, {"i": "RHEA:24935", "l": "H2O + imidazol-4-one = N-formimidoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635842", "l": "ULK3 phosphorylates GLI (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59702", "l": "D-cellopentaonate + H(+) => D-cellopentaono-1,5-lactone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40247", "l": "H2O + rhodomycin D = 10-carboxy-13-deoxycarminomycin + H(+) + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39286", "l": "a long-chain fatty acid(out) <=> a long-chain fatty acid(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848873", "l": "PTK6 phosphorylates ARAP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1222491", "l": "Lactoferrin scavenges iron ions (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60128", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49750", "l": "CO2 + 2 H2O + NADP(+) + proviolacein => 2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019176", "l": "dihydroneopterin monophosphate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33094", "l": "1,4-dihydroxy-6-naphthoate + all-trans-octaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-8 + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17699", "l": "5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine => pyridine + thiamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47040", "l": "5-taurinomethyluridine(34) in tRNA + AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] = 5-taurinomethyl-2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]"}, {"i": "EC:2.8.1.14", "l": "\"tRNA-5-taurinomethyluridine 2-sulfurtransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035013", "l": "myosuppressin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28294", "l": "(2E,6E)-farnesyl diphosphate = (E)-beta-caryophyllene + diphosphate"}, {"i": "EC:4.2.3.57", "l": "\"(-)-beta-caryophyllene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428883", "l": "Recruitment of CAP to ABL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21357", "l": "L-arabinitol + NAD(+) => H(+) + L-ribulose + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2314678", "l": "Aspirin acetylates PTGS1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130619", "l": "TGN-lysosomal vesicle coat assembly (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49556", "l": "H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] = H(+) + L-cysteinyl-[protein] + lactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954179", "l": "S100B gene expression is inhibited by ERBB4:TAB2:NCOR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912386", "l": "Ubiquitination of NOTCH1 by ITCH in the absence of ligand (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15310", "l": "(2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin] => biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052603", "l": "1-chloro-4-nitrosobenzene nitroreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.87"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265443", "l": "NPC1L1-mediated cholesterol uptake (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9650473", "l": "SERPING1 is secreted (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046961", "l": "proton-transporting ATPase activity, rotational mechanism"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033455", "l": "GCA codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0003899", "l": "DNA-directed 5'-3' RNA polymerase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044017", "l": "histone acetyltransferase activity (H3-K27 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189406", "l": "4 PBGs bind to form HMB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186773", "l": "PDGF dimer binds two receptors simultaneously (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64422", "l": "H(+)(in) + L-alanyl-L-proline(in) => H(+)(out) + L-alanyl-L-proline(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4608855", "l": "PRICKLE1 is degraded by the proteasome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19295", "l": "ADP + H(+) + monoacyl-sn-glycero-3-phosphate => a monoacylglycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.2.-", "l": "\"Acid--alcohol ligases (ester synthases)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179402", "l": "Active MMP3 can cleave pro-HBEGF to form active HBEGF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3095889", "l": "MMACHC reduces Cbl (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0089715", "l": "tRNA m6t6A37 methyltransferase activity"}, {"i": "MetaCyc:RXN0-7114"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047110", "l": "phenylglyoxylate dehydrogenase (acylating) activity"}, {"i": "MetaCyc:1.2.1.58-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58055", "l": "(2-aminoethyl)phosphonate + acetyl-CoA <=> (2-acetamidoethyl)phosphonate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66311", "l": "an inositol-1-phosphoceramide + GDP-alpha-D-mannose <=> an alpha-mannosylinositol-1-phosphoceramide + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.1", "l": "\"Pyruvate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046406", "l": "magnesium protoporphyrin IX methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390641", "l": "ADRA1A,B,D bind ADR,NAd (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20438", "l": "5D-5-O-methyl-chiro-inositol + NADP(+) => 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701534", "l": "p-Y705, S727 STAT3 dimer binds HIF1A gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30874", "l": "2-deoxy-D-ribose + ATP <=> 2-deoxy-D-ribose 5-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163676", "l": "Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50378", "l": "a ceramide(out) + ADP + H(+) + phosphate => a ceramide(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35239", "l": "tetracycline(in) = tetracycline(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210289", "l": "Recruitment of SYK to p-DAP12 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48205", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentadecanoyl-CoA => (2E)-pentadecenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66167", "l": "butanoyl-CoA + serotonin <=> CoA + H(+) + N-butanoylserotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445714", "l": "Aquaporin-3 passively transports water out of cell (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34221", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) + NADH => (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805122", "l": "AURKB binds TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27407", "l": "a ubiquinol + acetate + CO2 => a ubiquinone + H2O + pyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0070547", "l": "L-tyrosine aminotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15645", "l": "16 ATP + 16 H2O + N2 + 4 reduced [flavodoxin] = 16 ADP + 18 H(+) + H2 + 2 NH4(+) + 4 oxidized [flavodoxin] + 16 phosphate"}, {"i": "EC:1.19.6.1", "l": "\"Nitrogenase (flavodoxin)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17298", "l": "2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] => CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56153", "l": "(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine => (9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.206"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57288", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O = a guanosine in RNA + H(+) + lactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35531", "l": "cyclo(L-phenylalanyl-L-leucyl) + 2 O2 = albonoursin + 2 H2O2"}, {"i": "EC:1.3.3.13", "l": "\"Albonoursin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-179417", "l": "Multiubiquitination of Nek2A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21911", "l": "NADP(+) + scytalone <=> H(+) + NADPH + naphthalene-1,3,6,8-tetrol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692228", "l": "DMRT1 binds the SOX9 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682598", "l": "ATM phosphorylates HERC2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27752", "l": "2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine => 2'-deoxyinosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050009", "l": "isopropanol dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730847", "l": "Hydrolysis of PIP2 by PLCG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42654", "l": "diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046576", "l": "rhamnogalacturonan alpha-L-rhamnopyranosyl-(1->4)-alpha-D-galactopyranosyluronide lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54227", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphocholine <=> 2-(prostaglandin E2)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-982792", "l": "Growth hormone receptor binds JAK2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58328", "l": "(Z)-non-6-en-1-ol + NADP(+) = (Z)-non-6-enal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16784", "l": "a fatty acyl-CoA + H2O <=> a fatty acid + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0032037", "l": "myosin I heavy chain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9005995", "l": "MECP2 binds the SIN3A co-repressor complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.50"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2855047", "l": "Hydrolysis of internal thioester in C4b (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25561", "l": "9alpha-copalyl diphosphate => 9beta-pimara-7,15-diene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47857", "l": "ganglioside GD1a (d18:1(4E)) + H2O => ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388503", "l": "Oxytocin receptor bind oxytocin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24754", "l": "3 H(+) + red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin] => 2 oxidized [2Fe-2S]-[ferredoxin] + primary fluorescent chlorophyll catabolite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682863", "l": "RNF168 binds DNA DSBs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4791278", "l": "APC truncation mutants have impaired AXIN binding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48847", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39811", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676599", "l": "sBAFF trimer binds BAFFR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951727", "l": "cAMP binds PKA tetramer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8943279", "l": "GGT dimers hydrolyse GSH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23755", "l": "all-trans-undecaprenol + ATP <=> ADP + all-trans-undecaprenyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452102", "l": "p-STAT5 dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429415", "l": "SYK binds to integrin alphaIIb beta3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27275", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) => 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23566", "l": "2 berberine + 2 H2O => 2 columbamine + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102795", "l": "1-naphthaldehyde:oxygen oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755526", "l": "PIAS4 SUMOylates NR4A2 with SUMO2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005364", "l": "maltose:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65421", "l": "GMP(in) + NAD(+)(out) => GMP(out) + NAD(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17776", "l": "ATP + L-cysteine + tRNA(Cys) <=> AMP + diphosphate + L-cysteinyl-tRNA(Cys)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22511", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) <=> diphosphate + DNA(n+1)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218804", "l": "p38 MAPK activation by VEGFR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56924", "l": "ATP + L-threonyl-[Goodpasture antigen-binding protein] = ADP + H(+) + O-phospho-L-threonyl-[Goodpasture antigen-binding protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005166", "l": "neurotrophin p75 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64912", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32206", "l": "(R)-synephrine <=> (4-hydroxyphenyl)acetaldehyde + methylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473596", "l": "Collagen type I degradation by MMP15 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62412", "l": "(E)-feruloyl-CoA + H2O = acetyl-CoA + vanillin"}, {"i": "EC:4.1.2.61", "l": "\"Feruloyl-CoA hydratase/lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51095", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15302", "l": "D-apiitol + NAD(+) => aldehydo-D-apiose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851011", "l": "TRIM27 polyubiquitinates PTEN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811539", "l": "Reinforcement of the Cornified Envelope (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51613", "l": "(R)-2-hydroxyglutarate + oxaloacetate => (R)-malate + 2-oxoglutarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664867", "l": "NBR1 binds MAP1LC3B (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15426", "l": "coproporphyrinogen III + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202291", "l": "Activation of Lck (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10423", "l": "pyruvate + taurine <=> L-alanine + sulfoacetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373705", "l": "Caspase cleavage of DCC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34980", "l": "H(+)(in) => H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36953", "l": "(9Z)-heptadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => 2 [Fe(II)-cytochrome b5] + 2 H(+) + heptadecanoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050116", "l": "N,N-dimethylformamidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35326", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6813749", "l": "ALDH1A1 oxidises GA to DGA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34068", "l": "5-phospho-alpha-D-ribose 1-diphosphate + H(+) + trans,octa-cis-decaprenyl phosphate => diphosphate + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421485", "l": "Translocation of coproporphyrinogen III from the cytosol to the mitochondrial intermembrane space (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018741", "l": "alkyl sulfatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618328", "l": "ATAT acetylates microtubules (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48623", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione <=> (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032033", "l": "myosin II light chain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25742", "l": "N-hydroxy-L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358545", "l": "EXO1 interacts with MSH2:MSH3 (MutSbeta) and MLH1:PMS2 (MutLalpha) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62570", "l": "glycine + S-benzyl-L-cysteine => H2O + S-benzyl-L-cysteinylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57546", "l": "4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + zealexin A1 => (S)-beta-macrocarpene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37195", "l": "octadecanoyl-CoA + sn-glycerol 3-phosphate = 1-octadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21336", "l": "NAD(+) + pyridoxal = 4-pyridoxolactone + H(+) + NADH"}, {"i": "EC:1.1.1.107", "l": "\"Pyridoxal 4-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21703", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O <=> 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51607", "l": "2 H(+) + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin] <=> 4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2214324", "l": "Collagen type VII dimerization (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36148", "l": "acetyl-CoA + benzyl alcohol => benzyl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45105", "l": "6-demethylmitomycin A + S-adenosyl-L-methionine => mitomycin A + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48401", "l": "2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 => CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9670101", "l": "ATRX:DAXX binds to subtelomeric chromosomal regions (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58813", "l": "ATP + H2O + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate => AMP + diphosphate + H(+) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21977", "l": "[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite => [thioredoxin]-dithiol + adenosine 5'-phosphosulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39470", "l": "(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + NADPH <=> (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55671", "l": "11-cis-retinol--[retinol-binding protein] + NAD(+) <=> 11-cis-retinal--[retinol-binding protein] + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3782655", "l": "HDAC10 deacetylates histone (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29239", "l": "H(+)(in) + uracil(in) = H(+)(out) + uracil(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22119", "l": "luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP-alpha-D-glucuronate <=> H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] 4'-O-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306876", "l": "NLRP3 activation by small molecules (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30441", "l": "2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly) => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + 2 glycyl-tRNA(Gly)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070917", "l": "inositol phosphoceramide synthase regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692495", "l": "BACE1 cleaves APP(18-770) to APP(18-671) and APP(672-770) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21839", "l": "D-arabinonate <=> 2-dehydro-3-deoxy-D-arabinonate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627107", "l": "XIAP binds CASP7 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46468", "l": "an N-(acyl)-sphingosylphosphocholine(in) + ATP + H2O = ADP + an N-(acyl)-sphingosylphosphocholine(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375135", "l": "Basigin binds Matrix metalloproteinase-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396029", "l": "Latent TGF-beta-3 binds integrins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62465", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O => 2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31098", "l": "2-methylpropanoyl-CoA + A <=> (2E)-2-methylpropenoyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14604", "l": "L-lysine + O2 <=> 5-aminopentanamide + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11579", "l": "ATP + thiamine <=> AMP + H(+) + thiamine diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23717", "l": "(3Z)-dodecenoyl-CoA => (2E)-dodecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26035", "l": "2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,8'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10747", "l": "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) <=> 3,4-dihydroxybenzoate + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66545", "l": "L-cysteinyl-[protein] + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694409", "l": "Nucleotide exchange on RAB1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0046625", "l": "sphingolipid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18449", "l": "A + arsenite + H2O = AH2 + arsenate + H(+)"}, {"i": "EC:1.20.99.1", "l": "\"Arsenate reductase (donor)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47057", "l": "4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39666", "l": "a quinol + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) <=> a quinone + reduced coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17596", "l": "3-phenylpyruvate + L-glutamine <=> 2-oxoglutaramate + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373734", "l": "Nephrin interacts with Podocin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22921", "l": "L-glutamine + scyllo-inosose => 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33436", "l": "24-methylene-5alpha-cholest-8-en-3beta-ol => episterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37460", "l": "1D-myo-inositol hexakisphosphate + ATP => 1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63807", "l": "GDP-beta-L-gulose <=> GDP-beta-L-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201685", "l": "Beta-catenin is released from the destruction complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20857", "l": "an N-acylsphing-4-enine + H2O => a fatty acid + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33659", "l": "H(+) + N-tetracosanoylsphinganine + NADPH + O2 = H2O + N-(2-hydroxytetracosanoyl)-sphinganine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34752", "l": "ATP + N-acyl-15-methylhexadecasphing-4-enine => ADP + H(+) + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20544", "l": "H(+) + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2 <=> 2 H2O + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015620", "l": "ferric-enterobactin transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9671145", "l": "DKC1 binds SHQ1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42527", "l": "uridine(1911/1915/1917) in 23S rRNA <=> pseudouridine(1911/1915/1917) in 23S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236938", "l": "Partial proteolysis of antigen in phagolysosomes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174367", "l": "GCL ligates L-Glu to L-Cys (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38320", "l": "chorismate + H2O => (3R,4R)-3,4-dihydroxy-3,4-dihydrobenzoate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876868", "l": "ECE1 cleaves EDN1(53-90) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42486", "l": "D-sorbitol 6-phosphate(in) + L-histidyl-[protein] => D-sorbitol(out) + N(pros)-phospho-L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28190", "l": "2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382096", "l": "Formation of NR-NCOR Corepressor Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088130", "l": "PLK1 binds FOXM1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30017", "l": "alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP => alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052593", "l": "tryptamine:oxygen oxidoreductase (deaminating) activity"}, {"i": "KEGG.REACTION:R02173"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55599", "l": "globoside NOR1 + UDP-N-acetyl-alpha-D-galactosamine <=> globoside NORint + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37595", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15656", "l": "ATP + beta-D-fructose 6-phosphate <=> ADP + beta-D-fructose 2,6-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55938", "l": "all-trans-4-hydroxyretinal + H(+) + NADH => all-trans-4-hydroxyretinol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44556", "l": "4-hydroxybenzoate + all-trans-hexaprenyl diphosphate = 4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38977", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+) => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61598", "l": "[DsbD protein]-disulfide + [thioredoxin]-dithiol => [DsbD protein]-dithiol + [thioredoxin]-disulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18123", "l": "a thiol + NH4(+) + pyruvate => an S-substituted L-cysteine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50504", "l": "acetyl-CoA + N-terminal L-seryl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45226", "l": "(2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA => (3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052641", "l": "benzoic acid glucosyltransferase activity"}, {"i": "MetaCyc:RXN-11660"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48136", "l": "ganglioside GM3 + H2O = beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209760", "l": "Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53510", "l": "(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate => (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58623", "l": "N-decanoyl-(2S)-hydroxyglycine <=> decanamide + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31830", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-gamma-cadinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25545", "l": "ent-copalyl diphosphate => diphosphate + ent-pimara-9(11),15-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11008", "l": "a 5'-end triphospho-(purine-ribonucleoside) in mRNA + H2O = a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17384", "l": "(9Z,12Z)-octadecadienoate <=> (9Z,11E)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8863727", "l": "STON2 is neddylated (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102785", "l": "violaxanthin oxygenase activity"}, {"i": "MetaCyc:RXN-7886"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59653", "l": "D-xylotetraono-1,5-lactone + H2O => D-xylotetraonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070780", "l": "dihydrosphingosine-1-phosphate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295519", "l": "IL7R is phosphorylated on Y499 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-901047", "l": "Binding of ERp57 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43654", "l": "3-oxododecanoyl-[ACP] + CO2 + CoA => decanoyl-CoA + H(+) + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64928", "l": "dADP + H2O = dAMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61838", "l": "ergosteryl 3-beta-D-glucoside + H(+) + UDP => ergosterol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11336", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = deacetoxyvindoline + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.99", "l": "\"3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60667", "l": "H2O + NADPH <=> NADH + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16963", "l": "5-oxo-L-proline + L-lysine => epsilon-(gamma-L-glutamyl)-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17403", "l": "4-carboxy-2-hydroxy-cis,cis-muconate + H2O => 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44205", "l": "2-hydroxyhexadecanoate + ATP + CoA => 2-hydroxyhexadecanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955844", "l": "RBKS phosphorylates ribose to R5P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56853", "l": "reumycin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + toxoflavin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.22"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77608", "l": "Binding of A1CF to stem-looped RNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805740", "l": "SETD8 methylates TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "78.423603998002051", "identifiers": [{"i": "GO:0000987", "l": "cis-regulatory region sequence-specific DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665871", "l": "ADRM1 binds 26S proteasome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5229283", "l": "LCNs bind lipids (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222006", "l": "STK11 (LKB1) phosphorylates NUAK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44477", "l": "1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11219", "l": "a 2'-deoxyribonucleoside 5'-phosphate + ATP <=> a 2'-deoxyribonucleoside 5'-diphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58550", "l": "H2O + 2 monodehydro-L-ascorbate radical + N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-(9Z,12Z,15Z)-octadecatrienoylglycine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5681980", "l": "ATG12 binds ATG7 dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59563", "l": "H2O + N,N',N''-triacetylchitotriono-1,5-lactone <=> H(+) + N,N',N''-triacetylchitotrionate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5444516", "l": "Formation of MSH2:MSH6 Complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37142", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate <=> 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710106", "l": "ELANE cleaves GSDMD (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102812", "l": "4-coumaroyl-CoA:cyanidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity"}, {"i": "MetaCyc:RXN-8204"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62604", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = 7-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202731", "l": "JAM3 dimerises (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17609", "l": "L-seryl-[sulfatase] + S-adenosyl-L-methionine = 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + H(+) + L-methionine"}, {"i": "EC:1.1.98.7", "l": "\"Serine-type anaerobic sulfatase-maturating enzyme\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34986", "l": "sulfate(in) <=> sulfate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.-", "l": "\"Aspartic endopeptidases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51021", "l": "2 [Fe(III)cytochrome c] + a primary alcohol => 2 [Fe(II)cytochrome c] + an aldehyde + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418925", "l": "ADORA2A,B bind Ade-Rib (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66261", "l": "CoA + IC-asc-C7-AMP => AMP + H(+) + IC-asc-C7-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11099", "l": "NADP(+) + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50371", "l": "2-methylbutan-2-ol + H(+) + NADPH + O2 <=> 3-hydroxy-3-methylbut-1-ene + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045431", "l": "flavonol synthase activity"}, {"i": "RHEA:21088", "l": "2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2 = a flavonol + CO2 + H2O + succinate"}, {"i": "EC:1.14.20.6", "l": "\"Flavonol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19547", "l": "glycerol + H(+) + phosphocholine => H2O + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656244", "l": "DRD2 binds DA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112392", "l": "Resumption of elongation after recovery from pausing (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172183", "l": "Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25017", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate"}, {"i": "EC:3.1.3.67", "l": "\"Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14822", "l": "L-arabinose => L-ribulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.1.4", "l": "\"Rubredoxin--NAD(P)(+) reductase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106377", "l": "2-hydroxy-ATP hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47255", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74740", "l": "Binding of SHC1 to insulin receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769394", "l": "AKT phosphorylates CBY1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110506", "l": "Activated DTOR phosphorylates DS6K (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56940", "l": "S-methyl-5-thio-D-ribulose 1-phosphate = 2-(methylsulfanyl)acetaldehyde + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66712", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + stellata-2,6,19-triene = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + stellatate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159773", "l": "Furin cleaves pro-protein S to protein S (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0010485", "l": "H4 histone acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48519", "l": "1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O <=> dodecanoate + dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59704", "l": "D-cellohexaono-1,5-lactone + H2O = D-cellohexaonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50053", "l": "ATP + H2O + taurocholate(in) => ADP + H(+) + phosphate + taurocholate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731924", "l": "EDNRA binds EDNs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46447", "l": "(11Z)-hexadecenoyl-CoA + AH2 + O2 <=> (10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102626", "l": "parthenolide synthase activity"}, {"i": "MetaCyc:RXN-15531"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8931981", "l": "RUNX1 binds ESR1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29117", "l": "menaquinol-8 + NADP(+) => H(+) + menaquinone-8 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357472", "l": "PAK1-3 autophosphorylates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.45"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17383", "l": "(9Z,11E)-octadecadienoate => (9Z,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005007", "l": "fibroblast growth factor-activated receptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033712", "l": "1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44247", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-glycerol + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68615", "l": "Formation of ORC(1-6) complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42884", "l": "(R)-mevalonate + ATP = (R)-3-phosphomevalonate + ADP + H(+)"}, {"i": "EC:2.7.1.185", "l": "\"Mevalonate 3-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65908", "l": "3-hydroxy-L-kynurenine + pyruvate = H2O + L-alanine + xanthurenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047956", "l": "glycerol dehydrogenase [NADP+] activity"}, {"i": "RHEA:23592", "l": "glycerol + NADP(+) = D-glyceraldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46504", "l": "dodecanoyl-AMP + holo-[ACP] = AMP + dodecanoyl-[ACP] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694427", "l": "MIA3 binds procollagen VII (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014294", "l": "RAC2 binds effectors at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25770", "l": "3-carboxy-2-oxobutanoate + H(+) <=> 2-oxobutanoate + CO2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015132", "l": "prostaglandin transmembrane transporter activity"}, {"i": "REACT:R-HSA-5661188", "l": "Defective SLCO2A1 does not transport PGT substrates from extracellular region to cytosol (Homo sapiens)"}, {"i": "REACT:R-HSA-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75081", "l": "Formation of AT-AC B Complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66907", "l": "A + cannabinerolate <=> AH2 + cannabichromenate"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0061731", "l": "ribonucleoside-diphosphate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.21", "l": "\"Dolichyl-phosphooligosaccharide-protein glycotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19680", "l": "9'-cis-neoxanthin + O2 <=> (3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11034", "l": "3-chloro-cis,cis-muconate + H(+) => (2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050461", "l": "L-mimosine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797553", "l": "Protein 4.1 binds CASK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010210", "l": "IAA-Phe conjugate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37101", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GMP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904678", "l": "alpha-aminoacyl-tRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651828", "l": "PARG dePARylates PARP1,PARP2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62438", "l": "2-dehydro-3-deoxy-L-arabinonate + H2O => L-lyxonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61375", "l": "4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O <=> 4-methylumbelliferone beta-D-glucuronate(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20029", "l": "10-deoxysarpagine + NADP(+) = H(+) + NADPH + vellosimine"}, {"i": "EC:1.1.1.273", "l": "\"Vellosimine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30707", "l": "putrescine + pyruvate = 4-aminobutanal + L-alanine"}, {"i": "EC:2.6.1.113", "l": "\"Putrescine--pyruvate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52953", "l": "lithocholate + UDP-alpha-D-glucuronate => lithocholoyl-24-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57959", "l": "dimethyl sulfoxide + H(+) + NADH + O2 <=> dimethyl sulfone + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49418", "l": "alpha-D-ribose 1,5-bisphosphate + AMP + H(+) => ADP + alpha-D-ribose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56659", "l": "12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+) <=> 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374667", "l": "DCC interaction with SIAH2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39192", "l": "(2E)-docosenoyl-CoA + H(+) + NADPH => docosanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40335", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29145", "l": "a ubiquinone + 2 H(+)(out) + H2O + nitrite => a ubiquinol + 2 H(+)(in) + nitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12070", "l": "adenosine 3',5'-bisphosphate + H(+) + holo-[ACP] => apo-[ACP] + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12513", "l": "D-aspartate + H2O + O2 => H2O2 + NH4(+) + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001108", "l": "bacterial-type RNA polymerase holo enzyme binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1028820", "l": "Formation of VAF (virus-activated factor) complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9691174", "l": "RAC1 binds effectors at the ER membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57081", "l": "glutathione + S-methyl-1-thio-D-xylulose 5-phosphate => 1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730863", "l": "Phosphorylation of CARMA1 by PKC-theta (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043896", "l": "glucan 1,6-alpha-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34880", "l": "2 H2O + methyl 3-cyano-2-phenylpropanoate => 4-methoxy-4-oxo-3-phenylbutanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798748", "l": "Exocytosis of secretory granule lumen proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20338", "l": "(R)-2-O-sulfolactate + H2O => (R)-lactate + H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24880", "l": "1-dehydro-L-sorbose + AH2 => A + L-sorbopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3204303", "l": "MRE11 binds cytosolic DNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16019", "l": "5-amino-2-oxopentanoate + L-glutamate => 2-oxoglutarate + L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37887", "l": "S-adenosyl-L-methionine + small RNA 3'-end nucleotide = H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide"}, {"i": "EC:2.1.1.n8", "l": "\"Small RNA 2'-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033773", "l": "isoflavone 2'-hydroxylase activity"}, {"i": "EC:1.14.14.90", "l": "\"Isoflavone 2'-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10999", "l": "2-methylpropanal oxime + S-adenosyl-L-methionine <=> 2-methylpropanal O-methyloxime + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296043", "l": "Activation of HCN channels (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0034318", "l": "alcohol O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0004842", "l": "ubiquitin-protein ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10430", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019165", "l": "thiamine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63687", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + ATP <=> (4R,5S)-dethiobiotin + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61201", "l": "acetyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] => CoA + myricetin 3-O-[(6-O-acetyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624976", "l": "FOXO1,FOXO3 binds CAV1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052790", "l": "chitooligosaccharide deacetylase activity"}, {"i": "EC:3.5.1.-", "l": "\"In linear amides\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12445", "l": "hexadecanal + NADP(+) => (2E)-hexadecenal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198983", "l": "NKG2D homodimer interacting with ligands (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30893", "l": "acetate + H(+) + S-sulfo-L-cysteine => O-acetyl-L-serine + thiosulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12278", "l": "3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] => 3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11392", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50261", "l": "11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione => (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879562", "l": "SLCO2B1 has a narrow substrate specificity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022848", "l": "acetylcholine-gated cation-selective channel activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034856", "l": "2-hydroxyhexa-2,4-dienoate hydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33580", "l": "NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate => H(+) + NADH + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56312", "l": "3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate"}, {"i": "EC:3.6.1.52", "l": "\"Diphosphoinositol-polyphosphate diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018810", "l": "trans-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate hydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28878", "l": "H(+)(in) + L-tyrosine(in) <=> H(+)(out) + L-tyrosine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27746", "l": "H(+) + L-cysteine = CO2 + cysteamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34612", "l": "N-acyl-15-methylhexadecasphing-4-enine + UDP-alpha-D-glucose => H(+) + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0086075", "l": "gap junction channel activity involved in cardiac conduction electrical coupling"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044682", "l": "archaeal-specific GTP cyclohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16843", "l": "H(+) + precorrin-3A + S-adenosyl-L-homocysteine => precorrin-2 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109639", "l": "Formation of the closed pre-initiation complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203611", "l": "N-myristoylation of eNOS (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42650", "l": "(2,5-ethylene furandicarboxylate)(n-1) + 2,5-dicarboxyfuran + ethylene glycol + 2 H(+) => (2,5-ethylene furandicarboxylate)(n) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1369052", "l": "ABCAs mediate lipid influx (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5220959", "l": "TDG excises 5-formylcytosine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43865", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(in) => 1-hexadecanoyl-sn-glycero-3-phosphocholine(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050073", "l": "macrolide 2'-kinase activity"}, {"i": "RHEA:18333", "l": "ATP + oleandomycin = ADP + H(+) + oleandomycin 2'-O-phosphate"}, {"i": "EC:2.7.1.136", "l": "\"Macrolide 2'-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16951", "l": "H(+) + NADH + scyllo-inosose => myo-inositol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203774", "l": "Interaction of Csk with PAG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2468040", "l": "Cohesin binds PDS5 and WAPAL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389350", "l": "Activation of Cdc42 by pVav1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39447", "l": "(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25740", "l": "N-hydroxy-L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13322", "l": "(R)-3,3-dimethylmalate + NAD(+) => 3-methyl-2-oxobutanoate + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53961", "l": "4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + FMNH2 + O2 => 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + FMN + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15261", "l": "5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] = 5beta-cholestane-3alpha,7alpha,12alpha-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.139", "l": "\"5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050220", "l": "prostaglandin-E synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1449687", "l": "Corticosteroids bind to CBG in blood (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62431", "l": "3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA <=> 3,4-dihydroxybenzaldehyde + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033276", "l": "NTRK2 binds TIAM1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102176", "l": "cycloeucalenone reductase activity"}, {"i": "MetaCyc:RXN-11929"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30820", "l": "allantoin + H2O => allantoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009917", "l": "sterol 5-alpha reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18172", "l": "4-hydroxy-2-oxoglutarate <=> glyoxylate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199161", "l": "Fc gamma receptors interact with antigen-bound IgG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164513", "l": "3' PPT-primed initiation of plus-strand DNA synthesis  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48813", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14039", "l": "cortisone + H(+) + NADPH => 4,5beta-dihydrocortisone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32112", "l": "S-adenosyl-L-methionine + trans-resveratrol => 3-methoxy-4',5-dihydroxy-trans-stilbene + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30522", "l": "GTP + H(+) + phosphoenolpyruvate <=> diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16427", "l": "formate + 2 H(+) + NADH => formaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41422", "l": "CO2 + grixazone B + 4 H2O => 2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28971", "l": "H(+)(in) + shikimate(in) = H(+)(out) + shikimate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109702", "l": "PDPK1 phosphorylates AKT2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53509", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione => (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22368", "l": "L-ribulose 5-phosphate = D-xylulose 5-phosphate"}, {"i": "EC:5.1.3.4", "l": "\"L-ribulose-5-phosphate 4-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928615", "l": "EFNBs bind SFKs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426223", "l": "Cation influx mediated by TRPC3/6/7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730886", "l": "Phosphorylation of SHC by SYK kinase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28913", "l": "H(+)(in) + L-lysine(in) => H(+)(out) + L-lysine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388832", "l": "PI3K binds CD28 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.5", "l": "\"Thrombin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876868", "l": "ECE1 cleaves EDN1(53-90) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798257", "l": "PTPRS binds NTRK3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913371", "l": "GM-CSF receptor alpha:GM-CSF binds Bc (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48213", "l": "a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629373", "l": "NEIL3 recognizes and binds to spiroiminodihydantoin in telomeric DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31392", "l": "15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+) => all-trans-4,4'-diapolycopene + 4 FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74707", "l": "Binding of IRS to insulin receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11970", "l": "7,8-dihydro-7,8-dihydroxykynurenate + A => AH2 + kynurenate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018754", "l": "GDIs bind RHOH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41911", "l": "(3R)-hydroxyhexadecanoyl-[ACP] <=> (2E)-hexadecenoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32392", "l": "(1R,2R,4R)-dihydrocarveol + NAD(+) => (1R,4R)-dihydrocarvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11160", "l": "2-oxoglutarate + L-2,4-diaminobutanoate = L-aspartate 4-semialdehyde + L-glutamate"}, {"i": "EC:2.6.1.76", "l": "\"Diaminobutyrate--2-oxoglutarate transaminase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019768", "l": "high-affinity IgE receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196964", "l": "RFK:Mg2+ phosphorylates RIB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42049", "l": "3-hydroxybutanoyl-CoA + NAD(+) => acetoacetyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34690", "l": "AH2 + N-acyl-15-methylhexadecasphinganine + O2 <=> A + 2 H2O + N-acyl-15-methylhexadecasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029460", "l": "PAK1 phosphorylates LIMK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160931", "l": "Disassembly of tight junctions (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60355", "l": "2-heptyl-3-hydroxy-4(1H)-quinolone + O2 <=> CO + H(+) + N-octanoylanthranilate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49328", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spheroidene = 2-hydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12479", "l": "H2O + N-formyl-L-glutamate <=> formate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42875", "l": "N(4)-aminopropylspermidine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + N(4)-bis(aminopropyl)spermidine + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450348", "l": "Activated human JNKs migrate to nucleoplasm (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57098", "l": "1-deoxy-D-xylulose 5-phosphate + A + methanethiol => AH2 + S-methyl-1-thio-D-xylulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862771", "l": "PLA2G2A binds bacterial phospholipids (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.363", "l": "\"Ginsenoside 20-O-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19831", "l": "an aldehyde + H2O2 => a primary alcohol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56977", "l": "4-methylphenol + H2O + 2 oxidized [azurin] => 4-hydroxybenzyl alcohol + 2 H(+) + 2 reduced [azurin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34092", "l": "(5R)-5-phosphooxy-L-lysine + H2O => (S)-2-amino-6-oxohexanoate + NH4(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39182", "l": "(2E)-eicosenoyl-CoA + H(+) + NADPH <=> eicosanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18888", "l": "GDP-beta-L-fucose + NADP(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0099104", "l": "potassium channel activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10739", "l": "a primary alcohol + NAD(+) <=> an aldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12436", "l": "(E)-caffeoyl-CoA + putrescine = CoA + H(+) + N-caffeoylputrescine"}, {"i": "EC:2.3.1.138", "l": "\"Putrescine N-hydroxycinnamoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706304", "l": "Active FLT3 binds to GRAP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28261", "l": "cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate <=> cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52299", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.15"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605313", "l": "Defective MUTYH mutants do not cleave adenine mispaired with 8-oxoguanine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21965", "l": "an acylcholine + H2O => a carboxylate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445064", "l": "Activation of Rac1 by VAV2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130706", "l": "MHC class II antigen processing (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38254", "l": "hexadecan-1-ol + octadecanoyl-CoA <=> CoA + hexadecanyl octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15488", "l": "(1R,2S)-homoisocitrate <=> cis-homoaconitate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031995", "l": "insulin-like growth factor II binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132221", "l": "C5b:C6:C7:C8 and C9 bind to form membrane attack complex (MAC) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35408", "l": "H2O + medicarpin => 4'-methoxyisoflavan-2',4,7-triol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47250", "l": "2 [Fe(II)cytochrome c] + 3 H(+) + L-ascorbate => 2 [Fe(III)cytochrome c] + L-gulono-1,4-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39762", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353504", "l": "Insertion of correct bases opposite to the lesion by Pol eta (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24002", "l": "a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein] => a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2424485", "l": "Release of p-PLCG1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001067", "l": "pullulan binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2404144", "l": "Parenchymal atROL translocates to HSCs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043422", "l": "protein kinase B binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58374", "l": "(2E)-octenal + H(+) + NADPH => (E)-oct-2-en-1-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180597", "l": "Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37581", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014610", "l": "Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37169", "l": "(2E,6E)-farnesal + H(+) + NADH => (2E,6E)-farnesol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637796", "l": "Phosphorylation of SHC1 by p-5Y-EGFRvIII (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15411", "l": "1-O-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57600", "l": "2 [Fe(II)-cytochrome b5] + a 1-hexacosanoyl-2-acyl-phosphoglycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a 1-[(17Z)-hexacos-17-enoyl]-2-acyl-phosphoglycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16983", "l": "H(+) + maleylacetate + NADH => 3-oxoadipate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11434", "l": "7-O-methylvitexin 2''-O-beta-L-rhamnoside + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390846", "l": "D2D3,4 bind to DA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046904", "l": "calcium oxalate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32325", "l": "ent-kaur-16-en-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809254", "l": "MTMR8 binds MTMR9 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50001", "l": "butane + H(+) + NADH + O2 => butan-1-ol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34354", "l": "(2E)-geranial + H2O + NAD(+) <=> geranate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047078", "l": "3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19607", "l": "a chlorophyllide + H(+) + phytol => a chlorophyll + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4341072", "l": "SUMOylation of RARA with SUMO2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6795460", "l": "SGK1 phosphorylates MDM2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58816", "l": "ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate"}, {"i": "EC:6.3.2.53", "l": "\"UDP-N-acetylmuramoyl-L-alanine--L-glutamate ligase\""}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0019115", "l": "benzaldehyde dehydrogenase [NAD(P)+] activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798749", "l": "Exocytosis of specific granule lumen proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59361", "l": "carnosine + H2O => beta-alanine + L-histidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392195", "l": "Gi activation by P2Y purinoceptor 12 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56964", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + pyruvate = a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944522", "l": "miR-19a microRNA binds PTEN mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001648", "l": "proteinase activated receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15730", "l": "D-mannonate + NAD(+) => H(+) + keto-D-fructuronate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2562541", "l": "TLR4-induced ripoptosome assembly (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49525", "l": "2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2 => a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60625", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 H2O => 2 (9Z)-octadecenoate + 2 H(+) + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034875", "l": "caffeine oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56480", "l": "(4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 = (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41988", "l": "3beta-hydroxy-5alpha-pregnane-20-one + NAD(+) = 5alpha-pregnane-3,20-dione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944250", "l": "Association of procollagen type XXV (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12688", "l": "2 mycothiol + NADP(+) <=> H(+) + mycothione + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41710", "l": "1-O-hexadecyl-sn-glycero-3-phosphoethanolamine + acetate + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61858", "l": "betaenone C + 3 H2O + 3 NADP(+) => dehydroprobetaenone I + 3 H(+) + 3 NADPH + 3 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39143", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + NAD(+) = 3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451461", "l": "IRAK4 binds to the activated TLR7 or 21 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40498", "l": "N-[omega-(9Z,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine + O2 <=> N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419351", "l": "PAF receptor binds platelet activating factor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69142", "l": "Recruitment of Dna2 endonuclease (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48725", "l": "aurachin B + H(+) + H2O => 3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675473", "l": "SH2B binds JAK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74723", "l": "Endosome acidification (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40193", "l": "3-oxooctanoyl-CoA + H(+) + NADH => (3R)-hydroxyoctanoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031689", "l": "A3 adenosine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9010815", "l": "SLITs bind keratan sulfate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173705", "l": "C5b binds C6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16417", "l": "(S)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+) = H(+) + L-glutamate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65661", "l": "A + calciol + H2O => AH2 + calcidiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202241", "l": "Recruitment of SLP-76 to Gads (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798044", "l": "BTG2 binds CCR4-NOT complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62488", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44596", "l": "a fatty acyl-[ACP] + H2O = a fatty acid + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373746", "l": "SEMA4D interacts with CD45 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419351", "l": "PAF receptor binds platelet activating factor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0097364", "l": "stretch-activated, cation-selective, calcium channel activity involved in regulation of action potential"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28784", "l": "H2O + L-cysteinylglycine => glycine + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60674", "l": "H(+) + NADH + neral => NAD(+) + nerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44378", "l": "a 1-acyl-sn-glycero-3-phosphocholine(out) => a 1-acyl-sn-glycero-3-phosphocholine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877421", "l": "CTLA4 gene expression is stimulated by FOXP3 and inhibited by RUNX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977238", "l": "Activated TLR5/TLR15 homodimer recruits MyD88 adaptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17799", "l": "[(1->4)-beta-D-glucosyl](n+1) + GDP + H(+) => [(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465924", "l": "OPN1LW binds 11cRAL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193695", "l": "IRAK interacts with TRAF6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102638", "l": "[1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18847", "l": "2-hydroxy-3-oxopropanoate + H(+) + NADH => (R)-glycerate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43321", "l": "1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18115", "l": "a ribonucleoside 5'-triphosphate + ADP => a ribonucleoside 5'-diphosphate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45961", "l": "24,25-dihydrolanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12718", "l": "1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51507", "l": "a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D-glucose <=> a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53875", "l": "CTP + D-ribose 5-phosphate + H(+) <=> CDP-D-ribose + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9609921", "l": "SGTA binds Tail-anchored protein (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618093", "l": "ATP hydrolysis by HSP90 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12836", "l": "an N-acyl-D-glutamate + H2O <=> a carboxylate + D-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1013833", "l": "Cables link CDK5 and ABL1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011983", "l": "Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53839", "l": "a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-acyl-alpha-D-glucosamine <=> a UDP-2-N,3-O-bis((3R)-3-hydroxyacyl)-alpha-D-glucosamine + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35811", "l": "(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol = (-)-medicarpin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237119", "l": "Acireductone is oxidized to MOB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22782", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42438", "l": "L-ascorbate 6-phosphate(in) + L-histidyl-[protein] => L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102888", "l": "delta-cuprenene synthase activity"}, {"i": "MetaCyc:RXN-8431"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614591", "l": "Excess cysteine yields lanthionine and H2S (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24291", "l": "5-formimidoyltetrahydrofolate + glycine <=> (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811412", "l": "Active ARF recruits coatomer to the Golgi (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34500", "l": "1-deoxypentalenate + 2 H(+) + O2 + reduced 2[4Fe-4S]-[ferredoxin] => H2O + oxidized 2[4Fe-4S]-[ferredoxin] + pentalenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60052", "l": "a 3beta-hydroxy-4,4-dimethylsteroid + H(+) + NADH + O2 = a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874186", "l": "MBTPS1 (S1P) cleaves CREB3L4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65105", "l": "aculene D + L-prolyl-[peptidyl-carrier protein] => aculene B + holo-[peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23397", "l": "H2O + phloretin => 1,3,5-trihydroxybenzene + H(+) + phloretate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2995334", "l": "COX15 transforms heme O to heme A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52648", "l": "H2O + L-arabino-1,4-lactone 5-phosphate = 5-phospho-L-arabinonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641206", "l": "RSPOs bind LGRs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19311", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate + phosphate => 2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13130", "l": "cis-4-coumarate + UDP-alpha-D-glucose => 4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390641", "l": "ADRA1A,B,D bind ADR,NAd (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53042", "l": "17beta-estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP => 4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54612", "l": "2-oxoglutarate + 3-methylbutanoyl-CoA + O2 = 2-hydroxy-3-methylbutanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982637", "l": "Opsins binds G alpha-t (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28033", "l": "[thioredoxin]-disulfide + dGDP + H2O <=> [thioredoxin]-dithiol + GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200646", "l": "Cytosolic folate export across the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21014", "l": "4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP => 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58891", "l": "4-aminobenzoate + AH2 + 2 O2 <=> 4-nitrobenzoate + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264622", "l": "Cho is acetylated to AcCho by CHAT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52901", "l": "3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide => 15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168638", "l": "Activated IKK phosphorylates I-kappaB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "81.20444558259193", "identifiers": [{"i": "GO:0015215", "l": "nucleotide transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419645", "l": "Dimerization of LIMK1 by Hsp90 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000342", "l": "RNA cap 4 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805638", "l": "KAT6A acetylates TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19505", "l": "indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose = (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP"}, {"i": "EC:2.4.2.34", "l": "\"Indolylacetylinositol arabinosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41550", "l": "8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine => 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43897", "l": "3beta-hydroxy-5alpha-androstan-17-one + O2 + reduced [NADPH--hemoprotein reductase] => 3beta,7alpha-dihydroxy-5alpha-androstan-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008684", "l": "TBK1 phosphorylation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26373", "l": "[thioredoxin]-disulfide + prostamide F2alpha = [thioredoxin]-dithiol + prostamide H2"}, {"i": "RHEA:28214", "l": "[thioredoxin]-dithiol + prostaglandin H2 = [thioredoxin]-disulfide + prostaglandin F2alpha"}, {"i": "EC:1.11.1.20", "l": "\"Prostamide/prostaglandin F(2-alpha) synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20797", "l": "aldehydo-D-ribose => D-ribulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16389", "l": "4-hydroxybenzoate + 2 H(+) + NADH + O2 = CO2 + H2O + hydroquinone + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433456", "l": "Recruitment of STATs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0070002", "l": "glutamic-type peptidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102559", "l": "protein-(glutamine-N5) methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46705", "l": "ATP + H(+) + salicylate => 2-hydroxybenzoyl-5'-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624951", "l": "TNPO1 binds KIF17 dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.19"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37382", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine <=> 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047150", "l": "betaine-homocysteine S-methyltransferase activity"}, {"i": "REACT:R-HSA-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42683", "l": "2 hercynine + 2 L-selenocysteine + O2 <=> 2 H2O + 2 hercynylselenocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15775", "l": "ADP + dihydroxyacetone phosphate + H(+) => ATP + dihydroxyacetone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35113", "l": "2,5-didehydro-D-gluconate + H(+) + NADPH => 2-dehydro-L-idonate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15903", "l": "(2R)-3-phosphoglycerate => (2R)-2-phosphoglycerate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804379", "l": "PRMT5 binds TTC5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-901047", "l": "Binding of ERp57 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1370505", "l": "PRLR is phosphorylated at Ser-349 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48733", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O => [CysO sulfur-carrier protein]-C-terminal Gly-Gly + H(+) + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937419", "l": "CBR3 reduces DOX to DOXOL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18085", "l": "coenzyme B + coenzyme M + methanophenazine = coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine"}, {"i": "EC:1.8.98.1", "l": "\"Dihydromethanophenazine:CoB--CoM heterodisulfide reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48783", "l": "ATP + L-erythrulose <=> ADP + H(+) + L-erythrulose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956676", "l": "YAP1 binds TP73 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69685", "l": "CHEK2 phosphorylates TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982617", "l": "CYGB:O2 dissociates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32918", "l": "sn-glycero-3-phospho-1D-myo-inositol(out) <=> sn-glycero-3-phospho-1D-myo-inositol(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430183", "l": "NCK binds PAK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2201338", "l": "TRAF3 binds TICAM1:activated TLR4 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102644", "l": "monocyclic sesterterpenediol synthase activity"}, {"i": "MetaCyc:RXN-15756"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33934", "l": "all-trans-zeaxanthin + O2 <=> (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49481", "l": "2 H2O + L-1-piperideine-6-carboxylate + NADP(+) => H(+) + L-2-aminoadipate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55658", "l": "a carotenoid chi-end derivative + 2 AH2 => 2 A + a carotenoid beta-end derivative"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26555", "l": "angiotensin II + H2O => angiotensin-(1-7) + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41671", "l": "dihydrochelirubine + NADP(+) <=> chelirubine + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0008270", "l": "zinc ion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47081", "l": "17beta-hydroxyestr-4-en-3-one + H(+) + NADPH => 17beta-hydroxy-5beta-estran-3-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33610", "l": "(9Z)-octadecenoate + ATP + CoA <=> (9Z)-octadecenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22321", "l": "2 alpha-D-glucose 1-phosphate + H2O => D-maltose + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871370", "l": "p-Y281,292-RUFY1 translocates from cytosol to early endosome membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437084", "l": "ZnT3 transports zinc into synaptic vesicles (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.-", "l": "\"With other acceptors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17566", "l": "myo-inositol + S-adenosyl-L-methionine => 1D-1-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.9", "l": "\"Photosystem II\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229343", "l": "AXIN is phosphorylated in the destruction complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036050", "l": "Defective SGSH does not hydrolyse Heparan sulfate chain(2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198440", "l": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352981", "l": "phosphoenolpyruvate + H2O <=> 2-phosphoglycerate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672980", "l": "Dissociation of RAS:RAF complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50127", "l": "NAD(+) + resolvin D1 <=> 8-oxoresolvin D1 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25055", "l": "(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 => (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50805", "l": "glutathione + prostaglandin J2 => prostaglandin J2-S-(R)-glutathione"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030757", "l": "3-methylquercitin 7-O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40287", "l": "ATP + CoA + decanedioate = AMP + decanedioyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102142", "l": "[dermatan sulfate]-L-iduronyl 2-Osulfotransferase activity"}, {"i": "MetaCyc:RXN-11561"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102143", "l": "carboxynorspermidine dehydrogenase I activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13823", "l": "(S)-2-hydroxyglutarate + CO2 + succinate => 2-oxoglutarate + glutarate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693125", "l": "RHOF binds effectors at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210913", "l": "NEUROG3-dependent synthesis of INSM1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57902", "l": "adenosine in U6 snRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265862", "l": "Association of RAD51 with BRCA2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210300", "l": "Interaction of DAP12 and TREM2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.80", "l": "\"Long-chain fatty acid omega-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33297", "l": "(E)-9-(methylsulfanyl)nonanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-hexahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51146", "l": "(10,17)-dihydroperoxy-(7Z,11Z,13Z,15E,19Z)-docosapentaenoate => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + 2 O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102645", "l": "17(E)-cheilanthenediol synthase activity"}, {"i": "MetaCyc:RXN-15758"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052885", "l": "all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110453", "l": "Phosphorylation of PIP2 to PIP3 by Dp110 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46143", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 22R-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41462", "l": "a 1,2-diacylglycerol + a sphingomyelin => 1,2-diacyl-glycero-3-phosphocholine + an N-acylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19363", "l": "(2E,6E)-farnesyl diphosphate + diphosphate => (2E)-geranyl diphosphate + isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32941", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+) => a 1,2-diacyl-sn-glycerol + CDP-choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209179", "l": "ERF inhibits ETS2 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0009881", "l": "photoreceptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27982", "l": "7-carboxy-7-deazaguanine + ATP + NH4(+) = 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate"}, {"i": "EC:6.3.4.20", "l": "\"7-cyano-7-deazaguanine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944225", "l": "Association of procollagen type XVII (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58218", "l": "AH2 + serpentine => A + dihydroserpentine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693148", "l": "BCKDK phosphorylates BCKDH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61478", "l": "an N-octadecanoyl-sphingoid base + CoA + H(+) => a sphingoid base + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21530", "l": "[phosphate](n-1) + H(+) + phosphate => [phosphate](n) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41109", "l": "2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73806", "l": "AIR + CO2 => CAIR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69152", "l": "Removal of remaining Flap (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161775", "l": "ALOX12 oxidises LTA4 to LXA4/B4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37001", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-430347", "l": "MigFilin associates with Filamin and F-actin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013021", "l": "GDIs block activation of RHOB (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65969", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ATP + H2O => 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3341294", "l": "Superoxide reduces cytochrome c (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24510", "l": "H(+) + NADPH + prostaglandin E2 => NADP(+) + prostaglandin F2alpha"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41720", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52357", "l": "3'-phosphoadenylyl sulfate + pregnenolone => adenosine 3',5'-bisphosphate + H(+) + pregnenolone sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17451", "l": "3-linalylflaviolin + diphosphate => (2E)-geranyl diphosphate + flaviolin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863914", "l": "Transport of SEC22B, TAP and PLC from ER to ERGIC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052795", "l": "exo-alpha-(2->6)-sialidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1011598", "l": "DOCKs bind to RhoGEFs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22689", "l": "D-alanine + H2O + O2 => H2O2 + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43490", "l": "chlorophyll b + H(+) + NADH => 7(1)-hydroxychlorophyll a + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790036", "l": "Expression of STAT3-upregulated nuclear proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725345", "l": "NPM-ALK-dependent JUNB translation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23498", "l": "5-hydroxy-pentanoyl-CoA + acetate => 5-hydroxypentanoate + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33910", "l": "4-(methylamino)butanoate + H2O + O2 <=> 4-aminobutanoate + formaldehyde + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507875", "l": "Aquaporins passively transport urea into cells (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41368", "l": "1-O-tetradecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30345", "l": "FADH2 + fumarate => FAD + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034533", "l": "1,2-dihydroxy-7-hydroxymethylnaphthalene dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55352", "l": "all-trans-retinol = 13-cis-retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28617", "l": "(1Z,2S)-2-methylbutanal oxime <=> (2S)-2-methylbutanenitrile + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0019808", "l": "polyamine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000327", "l": "PLK1 phosphorylates BORA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17418", "l": "ATP + N-acetyl-D-glucosamine => ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66069", "l": "4-methyl-2-oxopentanoate + L-kynurenine => H2O + kynurenate + L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31199", "l": "(3S)-hydroxyoctanoyl-CoA = (2E)-octenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66145", "l": "5-methoxytryptamine + acetyl-CoA => CoA + H(+) + melatonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47192", "l": "[methyl-Co(III) methylated-thiol-specific corrinoid protein] + coenzyme M = [Co(I) methylated-thiol-specific corrinoid protein] + H(+) + methyl-coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31694", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (9R)-hydroperoxy-(10E,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64830", "l": "3-hydroxy-benzyl acetate + CoA => 3-hydroxybenzyl alcohol + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030626", "l": "U12 snRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9692880", "l": "HRH3 binds Hist (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62933", "l": "H2O + N(4)-acetylcytidine => acetate + cytidine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033776", "l": "phenylacetone monooxygenase activity"}, {"i": "RHEA:10124", "l": "H(+) + NADPH + O2 + phenylacetone = benzyl acetate + H2O + NADP(+)"}, {"i": "EC:1.14.13.92", "l": "\"Phenylacetone monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102238", "l": "geraniol kinase activity (ATP-dependent) activity"}, {"i": "MetaCyc:RXN-12307"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018720", "l": "phenol kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380201", "l": "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48711", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol <=> a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55929", "l": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] => fenbendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62361", "l": "FMNH2 + O2 + uracil => (Z)-3-ureidoacrylate + FMN-N(5)-oxide + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034903", "l": "endosulfan ether monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730902", "l": "Oligomerization of p-CARMA1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12800", "l": "(6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + scopolamine + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14080", "l": "3-oxopropanoate + L-alanine <=> beta-alanine + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49155", "l": "dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine <=> dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018803", "l": "4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682983", "l": "ATM phosphorylates WHSC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395320", "l": "Latent TGF-beta-1 binds integrins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41978", "l": "CMP + ganglioside GQ1b alpha (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E))"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008226", "l": "tyramine receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41544", "l": "8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine = 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.306", "l": "\"8-demethyl-8-(2-methoxy-alpha-L-rhamnosyl)-tetracenomycin-C 3'-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113638", "l": "Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102385", "l": "patchoulol synthase activity"}, {"i": "MetaCyc:RXN-13522"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63706", "l": "H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP => mycophenolate + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.1.-", "l": "\"Sulfurtransferases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25015", "l": "(E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56347", "l": "a 7-hydroxyisoflavone + UDP-alpha-D-glucose <=> a 7-hydroxyisoflavone 7-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65320", "l": "2-oxoglutarate + chrodrimanin E + O2 = chrodrimanin A + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034277", "l": "ent-cassa-12,15-diene synthase activity"}, {"i": "RHEA:25532", "l": "ent-copalyl diphosphate = diphosphate + ent-cassa-12,15-diene"}, {"i": "EC:4.2.3.28", "l": "\"Ent-cassa-12,15-diene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15171", "l": "L-glutamate + succinate => H2O + N-succinyl-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28225", "l": "3-dehydro-L-gulonate + ATP <=> 3-dehydro-L-gulonate 6-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225960", "l": "Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38626", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050537", "l": "mandelamide amidase activity"}, {"i": "MetaCyc:3.5.1.86-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2130194", "l": "ABL phosphorylates WAVEs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371467", "l": "SIRT1 deacetylates HSF1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9640167", "l": "RRAGA,B exchanges GDP for GTP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55888", "l": "[aequorin]--dioxetanone = [excited state blue fluorescent protein] + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614271", "l": "Autocleavage of ADGRG6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59349", "l": "D-maltobiono-1,5-lactone + H2O => D-maltobionate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086410", "l": "CDK1 phosphorylates BORA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14875", "l": "H(+) + indole-3-acetaldehyde + NADH => indole-3-ethanol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30232", "l": "H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine => (2E,6E)-farnesal + H2O2 + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34811", "l": "NADP(+) + tetrahydrocurcumin = dihydrocurcumin + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388811", "l": "CD28 homodimer binds B7-1 homodimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168635", "l": "PRKCB (PKC-beta) phosphorylates CARMA1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862771", "l": "PLA2G2A binds bacterial phospholipids (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18553", "l": "(2R,3S)-tartrate + NAD(+) = dihydroxyfumarate + H(+) + NADH"}, {"i": "EC:1.3.1.7", "l": "\"Meso-tartrate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51243", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (13R)-hydroperoxy-(9Z,11E)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473184", "l": "Follistatin (FST) binds Activin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211219", "l": "Translocation of caspase-3 to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237119", "l": "Acireductone is oxidized to MOB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783552", "l": "OSM binds LIFR:JAKs,OSMR:JAKs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55226", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35190", "l": "(Z)-3-aminoperacrylic acid + AH2 <=> (Z)-3-aminoacrylate + A + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804383", "l": "PRMT5 methylates TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0047264", "l": "heteroglycan alpha-mannosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381091", "l": "IRE1 dimer autophosphorylates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856945", "l": "PP2A methylation by LCMT1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55076", "l": "4-methylsulfanyl-2-oxobutanoate + H(+) = 3-methylsulfanylpropanal + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62892", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA = 6 CO2 + 7 CoA + 2 H2O + nor-toralactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13465", "l": "(S)-2,3-diaminopropanoate + oxalyl-CoA = CoA + N(3)-oxalyl-L-2,3-diaminopropanoate"}, {"i": "EC:2.3.1.58", "l": "\"2,3-diaminopropionate N-oxalyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050227", "l": "pteridine oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54631", "l": "2-oxoglutarate + dodecanoyl-CoA + O2 <=> 2-hydroxydodecanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730835", "l": "Autophosphorylation of PKC-theta (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40314", "l": "hexanoyl-CoA + O2 <=> (2E)-hexenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45305", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682826", "l": "LGI1 binds ADAM11 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189439", "l": "ALAD condenses 2 dALAs to form PBG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45561", "l": "L-isoleucine => D-allo-isoleucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3149519", "l": "MMACHC decyanates CNCbl (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45722", "l": "N-hexadecanoylsphing-4-enine(out) => N-hexadecanoylsphing-4-enine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687115", "l": "MYC positively regulates MAPKAPK5 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41559", "l": "2-oxoglutarate + L-arginyl-[ribosomal protein uL16] + O2 <=> (3R)-3-hydroxy-L-arginyl-[ribosomal protein uL16] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41483", "l": "an acyl-CoA + episterol <=> an episterol ester + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913675", "l": "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37020", "l": "A + D-serine + H2O => 3-hydroxypyruvate + AH2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863973", "l": "Fusion of ERC and phagosome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17679", "l": "2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4(+) => 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009383", "l": "rRNA (cytosine-C5-)-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60322", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371422", "l": "ATP hydrolysis by HSP70 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28817", "l": "4-hydroxybenzoate(out) + H(+)(in) => 4-hydroxybenzoate(in) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169406", "l": "ISGylation of host proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62876", "l": "AH2 + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate = A + semiviriditoxin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051109", "l": "crotonobetaine-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34930", "l": "H(+) + NADPH + selenodiglutathione <=> glutathione + glutathioselenol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50449", "l": "AH2 + prostaglandin G3 => A + H2O + prostaglandin H3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964567", "l": "The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds CDK1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2430535", "l": "MASTL phosphorylates ENSA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353023", "l": "3-phosphoglycerate + ATP <=> 1,3-bisphosphoglycerate + ADP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57644", "l": "(3-{(1R,2S,6S,8R)-2,8-dimethyl-3-[(E)-prop-1-enyl]-4,5-didehydrodecalin-2-yl}-3-oxopropanoyl)-[equisetin nonaketide synthase] + L-serine = H(+) + H2O + holo-[equisetin nonaketide synthase] + trichosetin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9690493", "l": "RHOB binds effectors on endosomes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10020", "l": "H2O + L-saccharopine + NADP(+) = (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH"}, {"i": "EC:1.5.1.10", "l": "\"Saccharopine dehydrogenase (NADP(+), L-glutamate-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36467", "l": "H2O + L-alanylglycine = glycine + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64970", "l": "dUDP + H(+) + phosphate => dUTP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163432", "l": "cholesterol ester + H2O -> cholesterol + fatty acid (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047148", "l": "methylamine-glutamate N-methyltransferase activity"}, {"i": "KEGG.REACTION:R01586"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49278", "l": "CDP + phytyl diphosphate => CTP + phytyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60795", "l": "3 2-oxoglutarate + gibberellin A53 + 3 O2 <=> 3 CO2 + gibberellin A17 + H(+) + H2O + 3 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4647594", "l": "SAHF formation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41015", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol = 1-O-hexadecyl-2-acetyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.4", "l": "\"Phospholipase D\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858498", "l": "SL (surrogate light chain) binds IgH to form pre-BCR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20060", "l": "2 H(+) + H2O + N-carbamoylsarcosine <=> CO2 + NH4(+) + sarcosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59424", "l": "benzylamine + H2O + O2 = benzaldehyde + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33218", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 3 isopentenyl diphosphate <=> all-trans-heptaprenyl diphosphate + 3 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350604", "l": "Agmatine + H2O <=> putrescine + urea (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43046", "l": "CoA + H(+) + N-octadecanoylhexadecasphinganine => hexadecasphinganine + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35908", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810376", "l": "ING2 binds PI5P (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952749", "l": "STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14978", "l": "3-carboxy-2,5-dihydro-5-oxofuran-2-acetate => 3-carboxy-cis,cis-muconate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694549", "l": "RTC completes synthesis of the minus strand genomic RNA complement (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21813", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26074", "l": "H2O + UDP-alpha-D-glucuronate => D-glucuronate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74712", "l": "Dissociation of IRS-P from insulin receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878054", "l": "HIPK2 phosphorylates RUNX1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618093", "l": "ATP hydrolysis by HSP90 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805470", "l": "AMPK phosphorylates TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2172678", "l": "PHF8 demethylates histone H4K20me1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9669854", "l": "KIT binds type II TKIs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30965", "l": "7,7',9,9'-tetra-cis-lycopene + a quinol => 7,9,9'-tri-cis-neurosporene + a quinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009309", "l": "RUNX2 binds STUB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45986", "l": "9alpha-hydroxy-3-oxochola-1,4-dien-22-oyl-CoA + H2O + NAD(+) => 3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418553", "l": "cAMP degradation by Phosphodiesterases (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56742", "l": "GalGb3Cer + H(+) + UDP => globoside Gb3Cer + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61183", "l": "quercetin + UDP-alpha-D-glucose <=> H(+) + quercetin 3-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43828", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451309", "l": "Edited Kainate Receptor binds glutamate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938815", "l": "RNF152 polyubiquitinates RRAGA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102450", "l": "kaempferide 7-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-13936"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913374", "l": "Phosphorylated SHC1 recruits SHIP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18166", "l": "biphenyl + H(+) + NADH + O2 => (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141040", "l": "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50879", "l": "a hydroperoxy polyunsaturated fatty acid + H(+) + NADPH <=> a hydroxy polyunsaturated fatty acid + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24036", "l": "a ribonucleoside 5'-phosphate + ATP = a ribonucleoside 5'-diphosphate + ADP"}, {"i": "EC:2.7.4.4", "l": "\"Nucleoside-phosphate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018848", "l": "pinocarveol isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49117", "l": "H(+) + NADPH + O2 + protodeoxyviolaceinate => deoxyviolaceinate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047651", "l": "alkylhalidase activity"}, {"i": "MetaCyc:ALKYLHALIDASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34483", "l": "4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA = 4-hydroxybenzalacetone + 2 CO2 + 2 CoA"}, {"i": "EC:2.3.1.212", "l": "\"Benzalacetone synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016913", "l": "follicle-stimulating hormone activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624353", "l": "NR1H2,3 binds the PLTP gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12107", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP <=> 7,8-dihydrofolate + dTMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.7.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57009", "l": "5,5'-dehydrodivanillate + H(+) + NADH + O2 => 2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + formaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65309", "l": "an ultra-long-chain di-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] => a 3-oxo-ultra-long-chain di-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39793", "l": "20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31150", "l": "3,4-dihydroxyphenylethyleneglycol + NAD(+) <=> 3,4-dihydroxymandelaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41551", "l": "8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine <=> 8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64826", "l": "1-naphthaleneacetate + NH4(+) => 1-naphthaleneacetamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170799", "l": "cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22839", "l": "a fatty acyl-[ACP] + H(+) + malonyl-[ACP] <=> a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507870", "l": "Aquaporins passively transport water out of cells (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3318415", "l": "ATF2 acetylates histone H2B, H4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939054", "l": "RUNX1 binds the PRKCB gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30248", "l": "2 H2O + 4 hnu + 2 plastoquinone-9 => O2 + 2 plastoquinol-9"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015304", "l": "glucose uniporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39443", "l": "(2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + NADPH = (11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28700", "l": "Mn(2+)(in) => Mn(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31385", "l": "lupeol => (S)-2,3-epoxysqualene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.8.4", "l": "\"Isovaleryl-CoA dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050240", "l": "pyrogallol 1,2-oxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3828025", "l": "DCN (decorin) degradation by MMP14 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23645", "l": "lithocholate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + hyodeoxycholate + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429036", "l": "SLC2A9 transports Fru, Glc, urate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40744", "l": "(20S)-ginsenoside Rd + 2 H2O => (20S)-ginsenoside C-K + 2 D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692749", "l": "CDC14A,B bind MAPK6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29813", "l": "ADP + H(+) + phosphate + thiamine(in) => ATP + H2O + thiamine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30931", "l": "L-cysteine + O-acetyl-L-homoserine = acetate + H(+) + L,L-cystathionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56276", "l": "ATP + L-proline = 3'-L-prolyl-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60710", "l": "(1R,3R)-chrysanthemate + 2 H(+) + NADH => (1R,3R)-chrysanthemal + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49214", "l": "20S,25-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399992", "l": "AKT1 E17K mutant phosphorylates forkhead box transcription factors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39649", "l": "5'-deoxyadenosine + A + dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + H(+) + L-methionine + NH4(+) => AH2 + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27476", "l": "ATP + D-glycero-beta-D-manno-heptose 7-phosphate <=> ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008720", "l": "D-lactate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9633742", "l": "EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429694", "l": "CERT:PPM1L:VAPA/B [ER] => CERT [cytosol] + PPM1L:VAPA/B [ER] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349455", "l": "Phosphorylation of MDM4 by ATM (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23971", "l": "(E)-coniferaldehyde + H2O + NAD(+) <=> (E)-ferulate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38701", "l": "(9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865774", "l": "TTLLs polyglutamylate tubulin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700154", "l": "Active ALK binds SHC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62822", "l": "1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol + 2 [Fe(III)-cytochrome b5] + H2O => 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42550", "l": "pseudouridine(746) in 23S rRNA => uridine(746) in 23S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161659", "l": "PGE2 is dehydrated to PGA2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672951", "l": "Inactive RAFs bind YWHAB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682388", "l": "Autophagosome maturation (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25411", "l": "ADP-alpha-D-glucose + D-glucose <=> ADP + alpha,alpha-trehalose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858500", "l": "CLEC10A binds Tn-MUC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388981", "l": "The Kiss receptor GPR54 binds kisspeptin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45681", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphate(in) => N-(hexadecanoyl)-sphing-4-enine-1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33137", "l": "malonate(out) + Na(+)(out) => malonate(in) + Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865320", "l": "CBFB binds RUNX1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043885", "l": "carbon-monoxide dehydrogenase (ferredoxin) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170159", "l": "Translocation of Cdc25 to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21094", "l": "dihydromacarpine + H(+) + S-adenosyl-L-homocysteine => 12-hydroxydihydrochelirubine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58877", "l": "4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709883", "l": "BIL:ALB scavenges O2.- (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22050", "l": "6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate => 7,8-dihydroneopterin 3'-triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66981", "l": "2-methylbutanoyl-CoA + H2O => 2-methylbutanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62205", "l": "1-propanol + 2 [Fe(III)cytochrome c] => 2 [Fe(II)cytochrome c] + 2 H(+) + propanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22014", "l": "precorrin-5 + S-adenosyl-L-homocysteine => precorrin-4 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53803", "l": "lithocholoyl-CoA + ursodeoxycholate <=> lithocholate + ursodeoxycholoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48622", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693561", "l": "RAD51 binds BRCA2 at resected DNA DSBs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130640", "l": "Recruitment of clathrin coated vesicle by Ii (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5333671", "l": "CLCAs self cleave (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5223313", "l": "ABCD4:LMBRD1 transports Cbl from lysosomal lumen to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17803", "l": "CoA + H(+) + N-acetyl-L-phenylalanine => acetyl-CoA + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30791", "l": "dGTP + pyruvate = dGDP + H(+) + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198756", "l": "ERK1/2 phosphorylates MSK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18535", "l": "CO2 + serotonin => 5-hydroxy-L-tryptophan + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55044", "l": "(3E,5Z)-tetradecadienoyl-CoA + H2O = (3E,5Z)-tetradecadienoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40294", "l": "ATP + CoA + tetradecanedioate <=> AMP + diphosphate + tetradecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9028730", "l": "Activated NTRK2 binds FRS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58970", "l": "1-naphthoate + H(+) + H2O2 => 1-naphthaldehyde + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58522", "l": "akuammicine + formate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (19S)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375384", "l": "Bombesin-like receptors bind bombesin homologues (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848250", "l": "ACBD6 binds LCFA-CoA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41678", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75862", "l": "Fall Back to Closed Pre-initiation Complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36571", "l": "sphinganine + tetradecanoyl-CoA = CoA + H(+) + N-(tetradecanoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58314", "l": "25-substituted-cholesterol + D-glucose => 25-substituted-cholesteryl beta-D-glucoside + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32010", "l": "9alpha-copalyl diphosphate <=> diphosphate + isopimara-8(14),15-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11035", "l": "(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate <=> 3-chloro-cis,cis-muconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20363", "l": "3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44869", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + ethanol => 1,2-diacyl-sn-glycero-3-phosphoethanol + choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51701", "l": "S-adenosyl-L-methionine + xanthogalenol => 4'-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944261", "l": "Association of procollagen type XIII (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419003", "l": "Interaction of Nectins with Afadin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432164", "l": "Ca2+ influx into the post-synaptic cell (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52900", "l": "3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide = 15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate"}, {"i": "EC:6.3.3.7", "l": "\"Ni-sirohydrochlorin a,c-diamide reductive cyclase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2509827", "l": "ITPA hydrolyses ITP to IMP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45033", "l": "4 [Fe(III)cytochrome c] + H2O + hydroxylamine => 4 [Fe(II)cytochrome c] + 5 H(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1011598", "l": "DOCKs bind to RhoGEFs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54189", "l": "H2O + N-acetyl-L-phenylalanine => acetate + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25640", "l": "H2O + NAD(+) + sulfoacetaldehyde <=> 2 H(+) + NADH + sulfoacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047261", "l": "steroid N-acetylglucosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678843", "l": "ISGylation of protein translation regulator 4EHP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15604", "l": "(E)-cinnamoyl-CoA + (R)-3-phenyllactate <=> (E)-cinnamate + (R)-3-phenyllactoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008448", "l": "N-acetylglucosamine-6-phosphate deacetylase activity"}, {"i": "REACT:R-HSA-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38973", "l": "(2E)-octadecenoyl-CoA + H2O2 => O2 + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43153", "l": "adenosine(58) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59952", "l": "2,6-dimethylheptanoyl-CoA + H2O = 2,6-dimethylheptanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10248", "l": "dUTP + H2O = diphosphate + dUMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51655", "l": "D-mannonate + NAD(+) <=> H(+) + keto-D-tagaturonate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354087", "l": "Recruitment of GRB2 to p-PTK2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20535", "l": "phosphate + pyridoxal => H2O + pyridoxal 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77609", "l": "Binding of APOBEC-1 to form editosome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66393", "l": "ATP + H2O + prostaglandin E1(in) => ADP + H(+) + phosphate + prostaglandin E1(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448951", "l": "Activation of p38 alpha/beta MAPK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036037", "l": "Defective IDUA does not hydrolyse Heparan sulfate chain(1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48333", "l": "a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose => a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45710", "l": "3-dehydrocarnityl-CoA + acetate => 3-dehydrocarnitine + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48621", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59808", "l": "L-tyrosine = D-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10887", "l": "(24R,24(1)R)-fucosterol epoxide <=> acetaldehyde + cholesta-5,24-dien-3beta-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2752115", "l": "SPP1 (osteopontin) binds CD44 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13266", "l": "1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine => 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35922", "l": "2'-deamino-2'-hydroxyneamine + UDP-alpha-D-glucose <=> H(+) + kanamycin D + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52894", "l": "H(+) + NADPH + nitrobenzene => H2O + NADP(+) + nitrosobenzene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44697", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H2O => a fatty acid + H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27535", "l": "(2E,6E)-farnesyl diphosphate + H2O => (3R,6E)-nerolidol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047799", "l": "cyclopentanone monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1248655", "l": "Trans-autophosphorylation of EGFRvIII mutant dimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36704", "l": "(2S,5S)-5-carboxymethylproline + ATP => (3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13862", "l": "D-xylose + NAD(+) => D-xylono-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191072", "l": "Synthesis of Cx43 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61660", "l": "(2E)-geraniol + ATP = (2E)-geranyl phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684169", "l": "G6B binds PTPN6,PTPN11 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50431", "l": "methanethiol + S-adenosyl-L-methionine <=> dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25476", "l": "(2E,6E)-farnesyl diphosphate = alpha-himachalene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617182", "l": "PRKACA phosphorylates PLN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17375", "l": "all-trans-capsanthin => all-trans-antheraxanthin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60005", "l": "(L-glutamyl)n+1-L-gamma-glutamyl-L-glutamyl-[protein] + H2O => (L-glutamyl)n-L-gamma-glutamyl-L-glutamyl-[protein] + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43818", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70982", "l": "Fumarate + H2O <=> (S)-Malate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15896", "l": "Co-sirohydrochlorin + 2 H(+) <=> Co(2+) + sirohydrochlorin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450348", "l": "Activated human JNKs migrate to nucleoplasm (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209322", "l": "In the absence of ARM, GRO binds to PAN and inhibits transcription (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050310", "l": "sulfite dehydrogenase activity"}, {"i": "RHEA:14281", "l": "2 [Fe(III)cytochrome c] + H2O + sulfite = 2 [Fe(II)cytochrome c] + 2 H(+) + sulfate"}, {"i": "EC:1.8.2.1", "l": "\"Sulfite dehydrogenase (cytochrome)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251942", "l": "Hikeshi binds HSP70s:ATP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010285", "l": "L,L-diaminopimelate aminotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948066", "l": "K63polyUb-IRAK1 dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58355", "l": "2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + O2 <=> CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784189", "l": "JAKs bind LIFR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40938", "l": "a 1-acylglycerone 3-phosphate + hexadecan-1-ol <=> 1-O-hexadecylglycerone 3-phosphate + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612278", "l": "ERBB4s80 binds SPARC gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44515", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56995", "l": "6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) <=> (+)-costunolide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10264", "l": "alpha-D-glucose = beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14732", "l": "beta-D-fructose 1,6-bisphosphate <=> D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3149492", "l": "cob(II)alamin dissociates from MMACHC:MMADHC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24884", "l": "H(+) + L-glutamate + NADPH => (S)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022911", "l": "CSPG is secreted (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61090", "l": "(2R,3R)-dihydroquercetin + CO2 + succinate => (S)-eriodictyol + 2-oxoglutarate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57398", "l": "3-O-acetylpapaveroxine + H(+) + S-adenosyl-L-homocysteine => (S)-S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44874", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47178", "l": "(2E)-butenoyl-CoA + H2O => (2R)-hydroxybutanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052634", "l": "C-19 gibberellin 2-beta-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50102", "l": "CoA + H(+) + N-dodecanoyl-taurine => dodecanoyl-CoA + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8856808", "l": "Recruitment of AP-2 complex and clathrin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55843", "l": "calcidiol + UDP-alpha-D-glucuronate <=> calcidiol 25-O-(beta-D-glucuronide) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.145", "l": "\"Deoxynucleoside kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63821", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) => H(+) + holo-[aryl-carrier protein] + petrobactin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63940", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + N-(hexanoyl)sphing-4-enine + O2 = 2 [Fe(III)-cytochrome b5] + 2 H2O + N-hexanoyl-sphinga-4E,14Z-dienine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636404", "l": "LAM translocates from the cell wall to the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64568", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one = ilicicolin H"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4837364", "l": "Secretion of SOD3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45554", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-tetradecanoylethanolamine => H2O + N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40891", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = H(+) + hexadecanoate + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.n2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418549", "l": "PKG1 phosphorylates BK channels (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33733", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a cardiolipin => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39887", "l": "2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pikromycin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46017", "l": "(20R)-20-hydroxypregn-4-en-3-one + NAD(+) => H(+) + NADH + progesterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296127", "l": "Activation of voltage gated Potassium channels (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139842", "l": "Binding of Syk tyrosine kinase (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24422", "l": "formate + N-terminal L-methionyl-[peptide] => H2O + N-terminal N-formyl-L-methionyl-[peptide]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381644", "l": "ER calcium channels open in response to activated PKA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48552", "l": "1-(9S,13S-12-oxo-10,15Z-phytodienoyl)-2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O = (10Z,15Z)-12-oxophytodienoate + 2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001857", "l": "complement component C1q receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47286", "l": "6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193068", "l": "CYP17A1 17-hydroxylates PREG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30576", "l": "3 menaquinone-8 + protoporphyrinogen IX => 3 menaquinol-8 + protoporphyrin IX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56221", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40026", "l": "9alpha-copalyl diphosphate + H2O <=> diphosphate + syn-copalol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008734", "l": "L-aspartate oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64621", "l": "(E)-sinapoyl alcohol + acetyl-CoA => (E)-sinapoyl actetate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018721", "l": "trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44402", "l": "H(+) + S-adenosyl-L-homocysteine + ubiquinol-6 => 3-demethylubiquinol-6 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44151", "l": "L-lysine <=> D-beta-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25065", "l": "3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) <=> 3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027281", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43218", "l": "(24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine => (24S)-hydroxycholesterol + 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6790454", "l": "SUMOylation of XPC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33241", "l": "aminoacetone + CO2 + NADH => L-threonine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424476", "l": "Activation of RAC1 by VAV2/3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373724", "l": "Nephrin binds NCK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8866277", "l": "AP-2 directly binds some endocytic cargo (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72621", "l": "Ribosomal scanning  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58014", "l": "2 5'-hydroxy-diadenylate 2',3'-cylic phosphate => cyclic tetraadenylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31788", "l": "H2O + tuberculosinyl diphosphate => (13R)-edaxadiene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35160", "l": "(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O => (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56358", "l": "2,4-dibromophenol + CO2 + 2 H2O + NADP(+) => 3-bromo-4-hydroxybenzoate + bromide + 3 H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40417", "l": "2,6,10,14-tetramethylpentadecanoate + CoA + H(+) => H2O + pristanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033891", "l": "CC-preferring endodeoxyribonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14701", "l": "2 CoA + NAD(+) = CoA-disulfide + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59822", "l": "adenosine 3'-diphosphate,5'-triphosphate + AMP => 2 ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38129", "l": "1-octadecanoyl-2-(9Z)-octadecenoylglycerol + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10079", "l": "H2O + lactose <=> D-galactose + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114284", "l": "Release of Cytochrome c from mitochondria (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26380", "l": "GTP <=> cyclic pyranopterin phosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40872", "l": "(9Z)-octadecenoyl-CoA + FAD + H(+) => (2E,9Z)-octadecadienoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20626", "l": "2 [Fe(III)-cytochrome c3] + H2 => 2 [Fe(II)-cytochrome c3] + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38503", "l": "1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654573", "l": "Activated FGFR1 binds SHC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140700", "l": "3',2'-cyclic GMP-AMP synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60865", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018754", "l": "GDIs bind RHOH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606789", "l": "ARSB hydrolyses DS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25711", "l": "L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112430", "l": "Formation of P-TEFb complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030060", "l": "L-malate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31208", "l": "FAD + H(+) + hexanoyl-CoA => (2E)-hexenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15941", "l": "H2O + N(2)-acetyl-L-ornithine = acetate + L-ornithine"}, {"i": "EC:3.5.1.16", "l": "\"Acetylornithine deacetylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43131", "l": "guanosine(10) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50574", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174706", "l": "chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876472", "l": "NPC2 binds CHOL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26274", "l": "Co-precorrin-3 + S-adenosyl-L-methionine => Co-precorrin-4 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399930", "l": "Activation of PAK by Rac1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672980", "l": "Dissociation of RAS:RAF complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53356", "l": "5,6-dihydrouridine(20b) in tRNA + NADP(+) = H(+) + NADPH + uridine(20b) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9029680", "l": "Caspase-7 translocates to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52030", "l": "a jasmonate + an L-alpha-amino acid => a jasmonyl-L-amino acid + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003834", "l": "beta-carotene 15,15'-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693604", "l": "XRCC4:LIG4 ligates DNA DSB ends during NHEJ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38175", "l": "all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32340", "l": "(+)-thujan-3-ol + NADP(+) => (+)-thujan-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003720", "l": "telomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41842", "l": "(3R)-hydroxyoctanoyl-[ACP] + NADP(+) => 3-oxooctanoyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30519", "l": "GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine"}, {"i": "EC:2.7.7.105", "l": "\"Phosphoenolpyruvate guanylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202510", "l": "Activation of TAK1-TAB2 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35057", "l": "(2E,4E)-2,5-dichloromuconate + H(+) => 3,6-dichlorocatechol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952996", "l": "E2F7 forms homodimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0101012", "l": "inositol 1,5-bisdiphosphate 2,3,4,6-tetrakisphosphate 1-diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64864", "l": "ITP + oxaloacetate = CO2 + IDP + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010013", "l": "N-1-naphthylphthalamic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41308", "l": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.25", "l": "\"Saccharopepsin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66868", "l": "3 O2 + quiannulatene + 3 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + quiannulatate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948027", "l": "RNASEs bind bacterial phospholipids (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16466", "l": "(R)-lactate + 2 [Fe(III)cytochrome c553] => 2 [Fe(II)cytochrome c553] + 2 H(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24890", "l": "1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) = 4-hydroxy-L-glutamate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371537", "l": "DBC1 binds SIRT1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950757", "l": "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48872", "l": "a gentamycin + GTP = a gentamycin 2''-phosphate + GDP + H(+)"}, {"i": "EC:2.7.1.190", "l": "\"Aminoglycoside 2''-phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47201", "l": "(24S)-7alpha-dihydroxycholesterol + NAD(+) => (24S)-7alpha,24-dihydroxycholest-4-en-3-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696271", "l": "RND1 binds effectors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49071", "l": "25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (1S)-1,25-dihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160874", "l": "HYAL1 hydrolyses (HA)50 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32471", "l": "demethylsuberosin + O2 + reduced [NADPH--hemoprotein reductase] = (7S)-marmesin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.66", "l": "\"Marmesin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31872", "l": "(S)-2,3-epoxysqualene => alpha-seco-amyrin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047822", "l": "hypotaurine dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814831", "l": "TBC1D20 binds RAB1:GTP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35191", "l": "noranthrone + O2 = H2O + norsolorinic acid"}, {"i": "EC:1.13.12.20", "l": "\"Noranthrone monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40643", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164505", "l": "Synthesis of full-length duplex viral DNA with a discontinuous plus strand (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928620", "l": "PAK1 autophosphorylates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25008", "l": "L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029451", "l": "Activation of RAC1 by VAV (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615933", "l": "SUMOylation of CBX5 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42077", "l": "2-hydroxyglutarate + acetyl-CoA => 2-hydroxyglutaryl-CoA + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46178", "l": "2-methylpropanoyl-CoA + AMP + diphosphate => 2-methylpropanoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199910", "l": "MSK1 activates ATF1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28460", "l": "biotin(out) => biotin(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28566", "l": "3 2,3-dihydroxybenzoyl-5'-AMP + 3 L-seryl-5'-AMP = 6 AMP + enterobactin + 7 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28610", "l": "H2O + XTP = diphosphate + H(+) + XMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13650", "l": "beta-D-glucose + NAD(+) => D-glucono-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53887", "l": "CDP-alpha-D-glucose + D-glucose 6-phosphate <=> alpha,alpha-trehalose 6-phosphate + CDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372529", "l": "Release of acetylcholine at the synapse (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27747", "l": "H(+) + L-cysteine => CO2 + cysteamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48677", "l": "6-trans-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-6-trans-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416929", "l": "PTGFR binds PGF2a (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051061", "l": "ADP reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32813", "l": "benzoate(out) => benzoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50145", "l": "ethyl (9Z)-hexadecenoate + H2O => (9Z)-hexadecenoate + ethanol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36065", "l": "diphosphate + kunzeaol => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912727", "l": "CBL binds VAV (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51196", "l": "chloride(out) + Na(+)(out) + serotonin(out) = chloride(in) + Na(+)(in) + serotonin(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34164", "l": "hydroquinone + O2 => (2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592278", "l": "Autocatalytic activation of proMMP2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8980691", "l": "RHOA GEFs activate RHOA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39885", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADPH => dTDP-6-deoxy-alpha-D-allose + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855375", "l": "PTPN22 dissociates from CSK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49359", "l": "2'-hydroxy-2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2',2'-dihydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070337", "l": "3'-flap-structured DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77094", "l": "Formation of cap binding complex (CBC) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60857", "l": "a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940561", "l": "MMP7 cleaves OPTC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809254", "l": "MTMR8 binds MTMR9 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43510", "l": "2-(dihydroxymethyl)-5-formylfuran => 2,5-diformylfuran + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43862", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174224", "l": "Dissociation of Cdc20 from APC/C complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373074", "l": "Receptor CCR9  binds CCL25 ligand (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2301205", "l": "SETD8 monomethylates histone H4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019727", "l": "mevaldate reductase (NAD+) activity"}, {"i": "RHEA:13221", "l": "(R)-mevalonate + NAD(+) = H(+) + mevaldate + NADH"}, {"i": "EC:1.1.1.32", "l": "\"Mevaldate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45911", "l": "chloroorienticin B + dTDP-beta-L-vancosamine <=> chloroeremomycin + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5225649", "l": "RBBP7 binds histone H3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035614", "l": "snRNA stem-loop binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684238", "l": "E and N are recruited to the M lattice (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047652", "l": "allantoate deiminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42896", "l": "L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.297", "l": "\"Peptide chain release factor N(5)-glutamine methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1253343", "l": "WWOX binds ERBB4s80 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27395", "l": "dichlorochromopyrrolate + H(+) + 2 H2O + NH4(+) => 2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3239014", "l": "MAPKAPK5 phosphorylates TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658195", "l": "Defective SLC5A5 does not cotransport Na+ with I- from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086020", "l": "gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936703", "l": "sulfite is reduced to sulfide (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112392", "l": "Resumption of elongation after recovery from pausing (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41224", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9660557", "l": "RAS:GTP binds RAL GDS proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37760", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22922", "l": "1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate => L-glutamine + scyllo-inosose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12536", "l": "H(+) + L-arogenate = CO2 + H2O + L-phenylalanine"}, {"i": "EC:4.2.1.91", "l": "\"Arogenate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55810", "l": "2 [Fe(III)-cytochrome b5] + a phytoceramide + H2O => 2 [Fe(II)-cytochrome b5] + a dihydroceramide + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50388", "l": "5a,11a-dehydrotetracycline + H(+) + NADPH + O2 = 5a,11a-dehydrooxytetracycline + H2O + NADP(+)"}, {"i": "EC:1.14.13.234", "l": "\"12-dehydrotetracycline 5-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2172666", "l": "RB1 binds condensin II (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6814831", "l": "TBC1D20 binds RAB1:GTP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40008", "l": "(+)-copalyl diphosphate + H2O => (+)-copalol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392530", "l": "p-S400-Cot phosphorylates NIK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33757", "l": "(4R)-hydroxysphinganine + hexadecanoate => H2O + N-hexadecanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34817", "l": "curcumin + 2 H(+) + 2 NADPH => 2 NADP(+) + tetrahydrocurcumin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008116", "l": "prostaglandin-I synthase activity"}, {"i": "KEGG.REACTION:R02267"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28238", "l": "calycosin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + pseudobaptigenin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112437", "l": "Formation of NELF complex  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106290", "l": "trans-cinnamate-CoA ligase activity"}, {"i": "RHEA:64788", "l": "(E)-cinnamate + ATP + CoA = (E)-cinnamoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20364", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097161", "l": "DH domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58602", "l": "H2O + 2 monodehydro-L-ascorbate radical + N-(9Z-octadecenoyl)-(2S)-hydroxyglycine => 2 L-ascorbate + N-(9Z-octadecenoyl)glycine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53203", "l": "17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta,19-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047653", "l": "allantoin racemase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "75.582117822819498", "identifiers": [{"i": "GO:0008234", "l": "cysteine-type peptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19799", "l": "1D-myo-inositol 1,4-bisphosphate + phosphate => 1D-myo-inositol 1,4,5-trisphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32415", "l": "(1S,2S,4R)-isodihydrocarveol + NAD(+) = (1S,4R)-isodihydrocarvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694442", "l": "CNIH2,3 bind GRIA1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693243", "l": "RHOD translocates to the Golgi membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202111", "l": "AKT1 phosphorylates eNOS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45332", "l": "7,8-dihydroneopterin + O2 = 7,8-dihydroxanthopterin + formate + glycolaldehyde + H(+)"}, {"i": "EC:1.13.11.81", "l": "\"7,8-dihydroneopterin oxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53814", "l": "(25R)-26-hydroxycholestanol + H2O + 2 oxidized [adrenodoxin] => cholestanol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38608", "l": "2'-phospho-cyclic ADP-ribose + nicotinate => nicotinate-adenine dinucleotide phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18273", "l": "H2O + O2 + putrescine = 4-aminobutanal + H2O2 + NH4(+)"}, {"i": "EC:1.4.3.10", "l": "\"Putrescine oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22609", "l": "H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate => (2S,6S)-2,6-diaminoheptanedioate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11964", "l": "5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5,6beta-triol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2214351", "l": "PLK1 phosphorylates GORASP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730837", "l": "Recruitment of GRB2:SOS to p-10Y-NTAL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247847", "l": "WLS is endocytosed to the early endosome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54543", "l": "H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] <=> beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32280", "l": "allantoate + 2 H(+) + 2 H2O => (S)-ureidoglycolate + CO2 + 2 NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382096", "l": "Formation of NR-NCOR Corepressor Complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47005", "l": "H2O + O-phospho-L-threonyl-[protein] => L-threonyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25506", "l": "beta-phellandrene + diphosphate => (2E)-geranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44828", "l": "(R)-carnitine + decanoyl-CoA = CoA + O-decanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42587", "l": "1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O <=> 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29708", "l": "1,6-anhydro-N-acetyl-beta-muramate(in) => 1,6-anhydro-N-acetyl-beta-muramate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38195", "l": "androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24567", "l": "a 3-oxo acid + succinyl-CoA <=> a 3-oxoacyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2512800", "l": "SCARB1:ligand is endocytosed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162363", "l": "p-T309,S474-AKT2:PIP3 phosphorylates PDE3B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755524", "l": "SUMOylation of NR1I2 with SUMO3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20369", "l": "betaine aldehyde + H2O + O2 = glycine betaine + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13670", "l": "5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+) => 3-hydroxy-2-methylpyridine-5-carboxylate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17795", "l": "H(+) + L-alanine + tRNA(Thr) => H2O + L-alanyl-tRNA(Thr)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47821", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-triphosphate + NADPH + O2 => 9-ribosyl-trans-zeatin 5'-triphosphate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.5.1", "l": "\"Nitrilase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874198", "l": "CREB3L2 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47047", "l": "3-dehydrocarnitine + acetyl-CoA <=> acetoacetate + N,N,N-trimethylglycyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33382", "l": "4-hydroxyeicosasphinganine 1-phosphate + H2O <=> (4R)-hydroxyeicosasphinganine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964274", "l": "G alpha (12) binds BTK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47982", "l": "dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose => dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28216", "l": "[thioredoxin]-disulfide + prostaglandin F2alpha => [thioredoxin]-dithiol + prostaglandin H2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904483", "l": "synthetic cannabinoid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12794", "l": "1D-myo-inositol hexakisphosphate + ATP => 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454208", "l": "Phosphorylation of beta and gamma subunits by LYN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56568", "l": "globoside Gb4Cer + UDP-N-acetyl-alpha-D-galactosamine = globoside IV3GalNAc-Gb4Cer + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27501", "l": "3',5'-di-O-methyltricetin + S-adenosyl-L-methionine = 3',4',5'-O-trimethyltricetin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23599", "l": "H2O + 2 NAD(+) + UDP-alpha-D-glucose <=> 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15715", "l": "a 6-acetyl-beta-D-galactoside + CoA => a beta-D-galactoside + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66200", "l": "O2 + pentanoyl-CoA = (2E)-pentenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111883", "l": "Hydrolysis of phosphatidylcholine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645481", "l": "TIFA oligomerization (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45478", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0052738", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, with a quinone or similar compound as acceptor"}, {"i": "EC:1.2.5.-", "l": "\"With a quinone or similar compound as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76386", "l": "CYP1A2 S-demethylates 6MMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944265", "l": "Association of procollagen type IV (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31966", "l": "9beta-pimara-7,15-dien-19-al + O2 + reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-dien-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130640", "l": "Recruitment of clathrin coated vesicle by Ii (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5577244", "l": "MSH2 variant:MSH6-defective DNA mismatch repair (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13303", "l": "a 1-acyl-sn-glycerol + a sterol ester => a 1,2-diacyl-sn-glycerol + a sterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645134", "l": "p-STAT5 dissociates from activator:STAT5 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42131", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoylsphinganine <=> a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47202", "l": "(24S)-7alpha,24-dihydroxycholest-4-en-3-one + H(+) + NADH => (24S)-7alpha-dihydroxycholesterol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9690461", "l": "FKBP1A binds tacrolimus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017447", "l": "MECP2 binds PPARG gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60036", "l": "H2O + N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate = 3-hydroxy-3-methylhexanoate + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0038199", "l": "ethylene receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53501", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O => 1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31812", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + viridiflorene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22226", "l": "1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O => 3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683964", "l": "ATM phosphorylates EYA1-4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050595", "l": "7-deoxyloganin 7-hydroxylase activity"}, {"i": "MetaCyc:1.14.13.74-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027281", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.5.-", "l": "\"Triphosphoric monoester hydrolases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418456", "l": "cGMP is degraded by PDEs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50425", "l": "(8Z,11Z,14Z)-eicosatrienoate + 2 O2 => prostaglandin G1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24023", "l": "2-(N(omega)-L-arginino)succinate <=> fumarate + L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29632", "l": "alpha-maltotetraose + H2O => alpha-D-glucose + alpha-maltotriose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65226", "l": "H(+) + NADPH + naphthalene-1,2-diol => (1R,2R)-1,2-dihydronaphthalene-1,2-diol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65710", "l": "beta-L-galactose 1-phosphate + GDP-alpha-D-mannose => alpha-D-mannose 1-phosphate + GDP-beta-L-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420083", "l": "PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32939", "l": "a 1,2-diacyl-sn-glycerol + CDP-choline = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56359", "l": "3-bromo-4-hydroxybenzoate + bromide + 3 H(+) + NADPH + O2 <=> 2,4-dibromophenol + CO2 + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928614", "l": "EFNB:GRB4 binds GIT1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18224", "l": "1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O <=> a 1-O-alkyl-2-acetyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38234", "l": "(9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA <=> 1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5617828", "l": "TRIP11:IFT20 dissociates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047498", "l": "calcium-dependent phospholipase A2 activity"}, {"i": "REACT:R-HSA-111883", "l": "Hydrolysis of phosphatidylcholine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46043", "l": "2'-deoxycytidine + ATP <=> ADP + dCMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70241", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102555", "l": "octanoyl transferase activity (acting on glycine-cleavage complex H protein)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636564", "l": "SapM binds RAB7A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65186", "l": "berkeleyone B + CO2 + H2O + succinate => 2-oxoglutarate + O2 + preaustinoid A1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418200", "l": "SRC-1 bound to ARRB2 is not activated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013147", "l": "RAC1 GDIs block activation of RAC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63389", "l": "2 A + Fe(II)-heme o + H2O => 2 AH2 + Fe(II)-heme a"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944240", "l": "Association of procollagen type III (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42553", "l": "uridine(31) in tRNA => pseudouridine(31) in tRNA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004484", "l": "mRNA guanylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50005", "l": "H(+) + NADPH + O2 + tetracycline => 11a-hydroxytetracycline + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48292", "l": "ganglioside GM1 + GDP-beta-L-fucose = ganglioside Fuc-GM1 + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871265", "l": "YAP1 binds TEAD4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63118", "l": "nitrate => peroxynitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33914", "l": "an N-alkylglycine + H2O + O2 <=> an alkylamine + glyoxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35032", "l": "L-serine(in) => L-serine(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0008940", "l": "nitrate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20454", "l": "scopoletin + UDP-alpha-D-glucose => H(+) + scopolin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983266", "l": "Kinesins bind microtubules (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.109"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534240", "l": "HSPG2 (perlecan) degradation by MMP14, MMP15 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53910", "l": "CoA + H(+) + N(6)-(2E)-butenoyl-L-lysyl-[protein] => (2E)-butenoyl-CoA + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204500", "l": "CyP60 chaperones Basigin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-877281", "l": "PIAS1 binds p-STAT1 dimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55832", "l": "cortisone + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxycortisone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199425", "l": "PHLPP dephosphorylates S473 in AKT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35141", "l": "CO2 + 2 CoA + demethoxycurcumin => (E)-4-coumaroyl-CoA + (E)-feruloylacetyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56149", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphocholine => CoA + hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35745", "l": "2 H2O + NADP(+) + versicolorin A => H(+) + NADPH + O2 + versicolorin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218804", "l": "p38 MAPK activation by VEGFR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.209", "l": "\"3(or 17)-alpha-hydroxysteroid dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57970", "l": "8-epi-inunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912496", "l": "Formation of meiotic holliday junction (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605595", "l": "Hexosaminidase A cleaves GalNAc from GM2 to form GM3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851890", "l": "MET phosphorylates SHC1-2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61453", "l": "H(+) + NADPH + O2 + oxytetracycline => 11a-hydroxy-oxytetracycline + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047355", "l": "CDP-glycerol glycerophosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875558", "l": "RAPGEF1 binds CRK,CRKL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69299", "l": "CDT1 binds geminin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483087", "l": "PI is exchanged with PC by PITPNB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1474266", "l": "Formation of collagen fibrils (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39301", "l": "(3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA + NADP(+) => (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166038", "l": "GPI-bound CD14 binds LPS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54472", "l": "1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29458", "l": "D-serine(in) <=> D-serine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030985", "l": "high molecular weight kininogen binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49907", "l": "(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H(+) + O2 <=> (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO2 + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36071", "l": "6-tuliposide A = D-glucose + tulipalin A"}, {"i": "EC:4.2.99.22", "l": "\"Tuliposide A-converting enzyme\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168038", "l": "Collagen type XV restin release (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466749", "l": "ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951966", "l": "EP300 acetylates RUNX3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710106", "l": "ELANE cleaves GSDMD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874080", "l": "SRC phosphorylates PTK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31807", "l": "(2E,6E)-farnesyl diphosphate = alpha-guaiene + diphosphate"}, {"i": "EC:4.2.3.87", "l": "\"Alpha-guaiene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37615", "l": "(9Z)-octadecenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5658435", "l": "RAS GAPs bind RAS:GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15992", "l": "(R)-mevalonate + CoA + 2 NADP(+) <=> (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390597", "l": "Release Of ADP From Myosin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017398", "l": "NOTCH3 coactivator complex binds HEYL gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55561", "l": "a hydroperoxyeicosatetraenoate => a hydroxy-epoxy-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50128", "l": "NAD(+) + resolvin D1 = 17-oxoresolvin D1 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33640", "l": "ATP + CoA + tetracosanoate => AMP + diphosphate + tetracosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985153", "l": "OASL binds DDX58 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20394", "l": "holo-[citrate lyase ACP] + S-acetylphosphopantotheine => acetyl-[citrate lyase ACP] + D-pantetheine 4'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689000", "l": "AADAC deacetylates PHEN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013145", "l": "RAC1 binds effectors at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21043", "l": "CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34353", "l": "geranate + 2 H(+) + NADH => (2E)-geranial + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32729", "l": "a very-long-chain 3-oxoacyl-CoA + CO2 + CoA => a very-long-chain acyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24780", "l": "C-13(2)-carboxypyropheophorbide a + H(+) = CO2 + pyropheophorbide a"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32017", "l": "(-)-delta-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48613", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] => [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.22"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.12"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653742", "l": "ATF4 and a CEBP protein bind the ATF5 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871260", "l": "YAP1 binds TEAD2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20301", "l": "ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)"}, {"i": "EC:6.1.1.19", "l": "\"Arginine--tRNA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.18", "l": "\"Polysaccharide O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015633", "l": "ABC-type zinc transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696605", "l": "USP12, USP26 deubiquitinate AR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070907", "l": "histidine:histamine antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73718", "l": "UBF-1 Binds rDNA Promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647660", "l": "GSDME (1-270) binds PIPs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052720", "l": "class II DNA-(apurinic or apyrimidinic site) endonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653886", "l": "B4GALT1 binds LALBA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-507868", "l": "Aquaporins passively transport water into cells (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15427", "l": "2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX => coproporphyrinogen III + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5099899", "l": "WNT5A binds FZD4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654514", "l": "KAL1 binds FGFR1c (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103040", "l": "aldose sugar dehydrogenase activity"}, {"i": "MetaCyc:RXN0-6371"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43505", "l": "5-hydroxymethylfurfural + O2 => 2,5-diformylfuran + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578777", "l": "DMPK phosphorylates PLN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13438", "l": "(E)-cinnamate + UDP-alpha-D-glucose => 1-O-(trans-cinnamoyl)-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004609", "l": "phosphatidylserine decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9646468", "l": "mTORC1 binds RHEB:GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28899", "l": "glycine(in) + H(+)(in) = glycine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48183", "l": "H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56418", "l": "alpha-D-glucose 1-phosphate + glycerol => 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15165", "l": "H2O + O2 + sarcosine = glyoxylate + H2O2 + methylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.-", "l": "\"With oxygen as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668605", "l": "RAC2:GTP binds NOX2 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052752", "l": "reduced coenzyme F420:heterodisulfide oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71164", "l": "homogentisate + O2 => maleylacetoacetate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-996755", "l": "ZFPM proteins bind GATA proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162092", "l": "carbovir monophosphate + ATP => carbovir diphosphate + ADP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47584", "l": "ganglioside GT2 (d18:1(4E)) + UDP-alpha-D-galactose = ganglioside GT1c (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0019206", "l": "nucleoside kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428625", "l": "Vesicular inhibitory amino acid transport (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29767", "l": "ATP + D-methionine(out) + H2O = ADP + D-methionine(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.1.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052883", "l": "tyrosine ammonia-lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49844", "l": "(-)-dehydrodiconiferyl acid + a quinone = (-)-dehydrodiconiferyl acid ketone + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53953", "l": "4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate => 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16392", "l": "4-hydroxybenzoate + 2 H(+) + NADH + O2 <=> CO2 + H2O + hydroquinone + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987223", "l": "IL10RB binds TYK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850831", "l": "KLK5 cleaves and activates KLK8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798743", "l": "Exocytosis of secretory granule membrane proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31961", "l": "9beta-pimara-7,15-dien-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-ol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61610", "l": "[DsbB protein]-disulfide + a quinol => [DsbB protein]-dithiol + a quinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42924", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.198", "l": "\"16S rRNA (cytidine(1402)-2'-O)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0008793", "l": "aromatic-amino-acid:2-oxoglutarate aminotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55095", "l": "D-fructose + UDP-alpha-D-glucose <=> H(+) + sucrose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175174", "l": "Association of Ku heterodimer with viral DNA ends (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167288", "l": "TFIIS-mediated recovery of HIV-1 elongation from arrest (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9649108", "l": "HTR3A pentamer binds 5HT (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381461", "l": "Plasmin proteolyzes IGF:IGFBP-3:ALS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62004", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc6S derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc6S derivative + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62652", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA = 6 CO2 + 7 CoA + H2O + YWA1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43925", "l": "NAD(+) + pregnenolone => H(+) + NADH + pregn-5-ene-3,20-dione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63363", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + O2 <=> (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-oxazole-[protein] + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56214", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP => O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111883", "l": "Hydrolysis of phosphatidylcholine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6791109", "l": "GADD45A binds PCNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17080", "l": "H2O + N,N-dimethylglycine + O2 <=> formaldehyde + H2O2 + sarcosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63948", "l": "H2O + sphinga-4E,14Z-dienine-1-phosphate = phosphate + sphinga-4E,14Z-dienine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51482", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51094", "l": "10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168915", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32071", "l": "geranylgeranyl diphosphate = (13E)-labda-7,13-dien-15-yl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64375", "l": "beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O <=> alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + N-acetyl-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33240", "l": "L-threonine + NAD(+) => aminoacetone + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48515", "l": "ATP + H2O + phosphinate(out) <=> ADP + H(+) + phosphate + phosphinate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44385", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + dodecanoyl-CoA => 1-heptadecanoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58811", "l": "2',3'-cGAMP + 2 H2O <=> AMP + GMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669158", "l": "NF2 binds PAK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74734", "l": "Re-integration of insulin receptor into plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56759", "l": "5 H(+) + 3 O2 + obtusifoliol + 6 reduced [2Fe-2S]-[ferredoxin] <=> 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806831", "l": "CYB5Rs reduce MetHb to HbA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67010", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40655", "l": "(R)-malate + succinyl-CoA = (R)-malyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951676", "l": "RUNX3 binds TEADs and YAP1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2464822", "l": "RDH12 reduces atRAL to atROL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37664", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63316", "l": "(9Z,12Z)-octadecadienoate + O2 = 9-hydroperoxy-(10E,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36325", "l": "(9Z)-octadecen-1-ol + CoA + 2 NADP(+) => (9Z)-octadecenoyl-CoA + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035501", "l": "MH1 domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66244", "l": "ATP + H(+) + IC-asc-C9 = diphosphate + IC-asc-C9-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-171122", "l": "LDL + LDLR => LDL:LDLR complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34656", "l": "C30 botryococcene + 2 S-adenosyl-L-methionine => 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 H(+) + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161775", "l": "ALOX12 oxidises LTA4 to LXA4/B4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46123", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30137", "l": "CoA + dodecanoate + H(+) => dodecanoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31068", "l": "6-amino-2-oxohexanoate => Delta(1)-piperideine-2-carboxylate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392834", "l": "Activation of EPACs by cAMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627369", "l": "SEPT4 binds XIAP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17179", "l": "CoA + O-octanoyl-(R)-carnitine => (R)-carnitine + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11689", "l": "ATP + L-leucine + tRNA(Leu) => AMP + diphosphate + L-leucyl-tRNA(Leu)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956025", "l": "AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610733", "l": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374692", "l": "Neogenin binds repulsive guidance molecules (RGDs) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936475", "l": "Negative regulation of DDX58/IFIH1 signaling by RNF216 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450494", "l": "HuR binds mRNAs in the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465924", "l": "OPN1LW binds 11cRAL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15625", "l": "Co-precorrin-6B + NAD(+) = Co-precorrin-6A + H(+) + NADH"}, {"i": "EC:1.3.1.106", "l": "\"Cobalt-precorrin-6A reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901006", "l": "Binding of Malectin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29480", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-epicubenol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54426", "l": "4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide => L-aspartyl-[protein] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661710", "l": "An unknown oxidase oxidises D-UBGN to UBN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39752", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50494", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56642", "l": "(9Z,12Z)-octadecadienoate + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61436", "l": "ADP + H2O = AMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018684", "l": "2,5-diketocamphane 1,2-monooxygenase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63918", "l": "5-fluorouridine 5'-phosphate + ADP + H(+) => 5-fluorouridine + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48041", "l": "globoside Gb4Cer + H2O => globoside Gb3Cer + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54585", "l": "a guanosine in 18S rRNA + S-adenosyl-L-methionine => an N(7)-methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33448", "l": "4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) => 4-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10891", "l": "4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H2O + NADP(+) <=> 4-carboxy-2-hydroxy-cis,cis-muconate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389083", "l": "Autophosphorylation of PDGF alpha receptors (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964759", "l": "Alternative endo-mannosidase I route (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047729", "l": "carnitine decarboxylase activity"}, {"i": "MetaCyc:CARNITINE-DECARBOXYLASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419644", "l": "Transphosphorylation of pLIMK1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44738", "l": "3-hydroxy-2,4-dioxopentyl phosphate + CoA => acetyl-CoA + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20571", "l": "L-ornithine + urea => H2O + L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211247", "l": "Cleavage of DNA by DFF40 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61583", "l": "(3S)-3-hydroxycyclohexane-1-carbonyl-CoA + NADP(+) <=> (5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27283", "l": "2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O => 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53665", "l": "(2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + NH4(+) => H(+) + 2 H2O + pyridinestrone carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55785", "l": "all-trans-4-oxoretinoate + UDP-alpha-D-glucuronate => all-trans-4-oxoretinoate 1-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173636", "l": "Formation of classic pathway C5 convertase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849428", "l": "PTPN1 binds PTK6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47027", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O <=> [DsrC protein]-S-sulfo-L-cysteine/L-cysteine + 3 AH2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006844", "l": "IL21:IL21R:JAK1 binds IL2RG:JAK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48069", "l": "ganglioside GM2 (d18:1(4E)) + H2O => ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59983", "l": "8-oxo-dGTP + H2O <=> 8-oxo-dGDP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36410", "l": "ATP + hydrogencarbonate + L-threonine <=> diphosphate + H2O + L-threonylcarbamoyladenylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38914", "l": "avenacoside B + H2O <=> 26-desgluco-avenacoside B + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59851", "l": "(2R,3S)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH <=> (S)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37211", "l": "2',3'-cyclic GMP + H2O = guanosine 2'-monophosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57755", "l": "2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH <=> C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097620", "l": "(R)-mandelate dehydrogenase activity"}, {"i": "RHEA:43112", "l": "(R)-mandelate + NAD(+) = H(+) + NADH + phenylglyoxylate"}, {"i": "EC:1.1.1.379", "l": "\"(R)-mandelate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247999", "l": "EGFRvIII mutant binds chaperone proteins HSP90 and CDC37. (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1214188", "l": "PRDM9 trimethylates histone H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19791", "l": "4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH => 4-(dimethylamino)azobenzene + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38154", "l": "carbonyl sulfide + H2O <=> CO2 + H(+) + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199112", "l": "CRTAM binds to NECL2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388829", "l": "SHP2 phosphatase binds CTLA-4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31838", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-3-dehydro-6-deoxy-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10033", "l": "[protein]-C-terminal-L-glutamine + H2O => [protein]-C-terminal-L-glutamate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53068", "l": "4-methoxyestrone + UDP-alpha-D-glucuronate = 4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48585", "l": "2 H2O + 2 leukotriene A4 + O2 => 2 lipoxin A4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60035", "l": "8-oxo-GTP + H2O <=> 8-oxo-GDP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50133", "l": "ethyl hexadecanoate + H2O => ethanol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10623", "l": "(E)-cinnamaldehyde + CoA + NADP(+) <=> (E)-cinnamoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797090", "l": "CCNK binds CDK12 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190682", "l": "Connexin synthesis (generic) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54029", "l": "a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57742", "l": "a trans-Delta(2)-meromycolyl-[ACP] + H(+) + NADH => a 2,3-saturated meromycolyl-[ACP] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15533", "l": "(R)-3-sulfolactate + NAD(+) = 3-sulfopyruvate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36995", "l": "(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2327733", "l": "FN1 binds Collagen types I-V, VII (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443439", "l": "c-Src binds Raf1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18575", "l": "chelirubine + H2O2 => dihydrochelirubine + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18307", "l": "CoA + N-acetyl-4-O-acetylneuraminate => acetyl-CoA + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013159", "l": "CDC42 GEFs activate CDC42 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31055", "l": "estrone 3-sulfate + H2O = estrone + H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40094", "l": "26-hydroxyhexacosanoate + NAD(+) <=> 26-oxohexacosanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416562", "l": "p190RhoGAP binds Plexin-B1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50906", "l": "H(+) + N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine => L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1236970", "l": "Proteasomal clevage of exogenous antigen (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41882", "l": "dodecanoyl-[ACP] + NADP(+) => (2E)-dodecenoyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25224", "l": "H(+) + L-cysteate <=> CO2 + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951951", "l": "RUNX3 binds EP300 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62610", "l": "S-sulfanylglutathione + ubiquinol-10 => glutathione + H(+) + hydrogen sulfide + ubiquinone-10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37033", "l": "2-dehydro-3-deoxy-D-arabinonate + H2O => D-ribonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6813740", "l": "GDE1 hydrolyzes GroPIns (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54109", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + guaia-4,6-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60983", "l": "12-hydroxydodecanoate + NAD(+) <=> 12-oxododecanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53147", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734687", "l": "ORC6 is phosphorylated on T195 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23334", "l": "(2R)-3-phospho-glyceroyl phosphate + GDP => (2R)-3-phosphoglycerate + GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222641", "l": "Carboxymycobactin binds LTF:2xFe3+:2xCO3(2-) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62595", "l": "(S)-8-oxocitronellyl enol + NADP(+) <=> (6E)-8-oxogeranial + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390329", "l": "Dephosphorylation of AKT by PP2A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679028", "l": "JAK3 binds JAK3 inhibitors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58490", "l": "H2O + NAD(+) + succinate semialdehyde + trimethylamine => 4-(trimethylamino)butanoate + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21341", "l": "1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 => 2 vanillin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55166", "l": "H2O + L-isoleucine-12-hydroxyjasmonate + NADP(+) => a jasmonyl-L-isoleucinate + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57354", "l": "H(+) + H2O + lutein + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + zeinoxanthin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32287", "l": "(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate"}, {"i": "EC:4.2.1.33", "l": "\"3-isopropylmalate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004655", "l": "porphobilinogen synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55217", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + rhizathalene A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389463", "l": "Proteinase-activated receptors can bind thrombin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042913", "l": "group A colicin transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949580", "l": "F1Fo ATP synthase dimerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028598", "l": "Phosphorylation of YAP by LATS1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28387", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine => di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28802", "l": "H2O + L-prolinylglycine <=> glycine + L-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730837", "l": "Recruitment of GRB2:SOS to p-10Y-NTAL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382056", "l": "Crk binds to the active PDGF receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36426", "l": "2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013438", "l": "RHOD binds effectors at the endosome membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22469", "l": "GTP + 3 H2O => 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852331", "l": "GTSE1 translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65018", "l": "4-hydroxychlorothalonil + chloride + 2 H(+) => chlorothalonil + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23085", "l": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA => 7-methyl-3-oxooct-6-enoyl-CoA + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49994", "l": "H2O + NAD(+) + propan-2-ol => H(+) + NADH + O2 + propane"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204169", "l": "PDP dephosphorylates p-lipo-PDH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46671", "l": "21-hydroxyprogesterone + H(+) + NADPH <=> 5beta-dihydrodeoxycorticosterone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50581", "l": "acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41452", "l": "5-methyl-1-naphthoate + H(+) + NADPH + O2 = 3-hydroxy-5-methyl-1-naphthoate + H2O + NADP(+)"}, {"i": "EC:1.14.13.189", "l": "\"5-methyl-1-naphthoate 3-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004052", "l": "arachidonate 12(S)-lipoxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10539", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O <=> 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.20"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034710", "l": "inhibin complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696358", "l": "TREM,CD300 binds lipids (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156930", "l": "GTP-binding activates eEF2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37824", "l": "(R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 => 2,4-dichlorophenol + CO2 + pyruvate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65812", "l": "2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + AH2 + O2 = A + H2O + N(6)-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-2-(methylsulfanyl)adenosine(37) in tRNA"}, {"i": "EC:1.14.99.69", "l": "\"tRNA 2-(methylsulfanyl)-N(6)-isopentenyladenosine(37) hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710353", "l": "GSDMD (1-275) binds cardiolipin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912680", "l": "Inhibition of JAK kinase activity by SOCS1/3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018673", "l": "anthraniloyl-CoA monooxygenase activity"}, {"i": "MetaCyc:ANTHRANILOYL-COA-MONOOXYGENASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37123", "l": "sphing-4-enine + tetracosenoyl-CoA = CoA + H(+) + N-(tetracosenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20541", "l": "H(+) + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2 = 2 H2O + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961934", "l": "CDK1 gene expression is stimulated by E2F1 and repressed by RBL1 and RBL2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692408", "l": "NPR2 binds NPPC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937814", "l": "RUNX3 translocates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54769", "l": "[LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine => [LarE protein]-dehydroalanine + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174070", "l": "Association of Cdh1 with the APC/C (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379867", "l": "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47018", "l": "[DsrC protein]-dithiol + 2 AH2 + 2 H(+) + sulfite => [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 2 A + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29155", "l": "2 H(+)(out) + nitrite(out) + 3 ubiquinol-8(in) = 2 H2O(out) + NH4(+)(out) + 3 ubiquinone-8(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23859", "l": "H(+) + Hg + NADP(+) <=> Hg(2+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11293", "l": "2 H(+) + O2 + rifamycin B => H2O2 + rifamycin O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176973", "l": "Association of MCM8 with ORC:origin complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13357", "l": "3-hydroxypropanoate + NAD(+) = 3-oxopropanoate + H(+) + NADH"}, {"i": "EC:1.1.1.59", "l": "\"3-hydroxypropionate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34226", "l": "6-hydroxypseudooxynicotine + A + H2O <=> 2,6-dihydroxypseudooxynicotine + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15981", "l": "H(+) + S-adenosyl-L-methionine = CO2 + S-adenosyl 3-(methylsulfanyl)propylamine"}, {"i": "EC:4.1.1.50", "l": "\"Adenosylmethionine decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49351", "l": "2,2-dihydroxyspirilloxanthin <=> 2-oxospirilloxanthin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52665", "l": "a short-chain (3S)-3-hydroxyacyl-CoA => a short-chain (2E)-enoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39149", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + acetyl-CoA => 3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0004970", "l": "ionotropic glutamate receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417908", "l": "P2RY1 binds ADP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448632", "l": "IL34 dimerizes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61536", "l": "ent-kaur-16-ene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = ent-kaur-16-en-19-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31108", "l": "3-phenylpyruvate + O2 => (2-hydroxyphenyl)acetate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56939", "l": "17beta-hydroxy-androst-5-en-3-one <=> testosterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-443439", "l": "c-Src binds Raf1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709842", "l": "MAVS binds TOMM70 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.66"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047693", "l": "ATP diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.2.3", "l": "\"P-type Na(+) transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41877", "l": "(3R)-hydroxydodecanoyl-[ACP] => (2E)-dodecenoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43076", "l": "erythrodiol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oleanolic aldehyde + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20192", "l": "5,6-dihydrouracil + NAD(+) <=> H(+) + NADH + uracil"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25179", "l": "3-methylbutanoyl-CoA + CO2 + NADH => 4-methyl-2-oxopentanoate + CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-139941", "l": "Binding of IP3 to IP3 receptor (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39821", "l": "2-hydroxydocosanoate + 2 [Fe(III)-cytochrome b5] + H2O => 2 [Fe(II)-cytochrome b5] + docosanoate + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849882", "l": "SALMs 1-4 bind reticulon 3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14855", "l": "4-hydroxybenzoyl-CoA + chloride + H(+) => 4-chlorobenzoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5336182", "l": "GPR37 binds prosaptide (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30255", "l": "2 a ubiquinol + O2 = 2 a ubiquinone + 2 H2O"}, {"i": "EC:1.10.3.11", "l": "\"Ubiquinol oxidase (non-electrogenic)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31972", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + NADPH + O2 => 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682967", "l": "WHSC1 binds DNA DSBs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686587", "l": "ABL1 phosphorylates RAD52 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38049", "l": "2 [Fe(III)-cytochrome b5] + a (9Z,12E)-octadecadienoyl-containing glycerolipid + 2 H2O => 2 [Fe(II)-cytochrome b5] + a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54939", "l": "(2E)-decenoyl-[ACP] + H(+) + NADH <=> decanoyl-[ACP] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56081", "l": "[Rab1 protein]-L-serine + CDP-choline => [Rab1 protein]-O-phosphocholine-L-serine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3076905", "l": "Extracellular BTD hydrolyses BCTN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32716", "l": "(2R,3S)-3-methylmalate + NAD(+) => 2-oxobutanoate + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55032", "l": "an N-methylornithine lipid + S-adenosyl-L-methionine = an N,N-dimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8955844", "l": "RBKS phosphorylates ribose to R5P (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65379", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidyl-adenosine in mRNA + 2 S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidyl-adenosine in mRNA + H(+) + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751013", "l": "Inactive G alpha (s) reassociates with G beta:gamma (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9699163", "l": "Defective BARD1 does not bind BRCA1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12068", "l": "apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]"}, {"i": "EC:2.7.8.7", "l": "\"Holo-[acyl-carrier-protein] synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004839", "l": "ubiquitin activating enzyme activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21886", "l": "H(+) + sulfate + thiosulfate => H2O + trithionate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66079", "l": "2-oxopentanoate + L-kynurenine <=> H2O + kynurenate + L-2-aminopentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624956", "l": "PDE6D binds INPP5E (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14718", "l": "D-erythrose 4-phosphate + H2O + phosphoenolpyruvate => 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37734", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977301", "l": "Histidine is decarboxylated to histamine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003974", "l": "UDP-N-acetylglucosamine 4-epimerase activity"}, {"i": "RHEA:20517", "l": "UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-galactosamine"}, {"i": "EC:5.1.3.7", "l": "\"UDP-N-acetylglucosamine 4-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29418", "l": "(S)-lactate(in) + H(+)(in) <=> (S)-lactate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033814", "l": "propanoyl-CoA C-acyltransferase activity"}, {"i": "MetaCyc:2.3.1.176-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0005092", "l": "GDP-dissociation inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641229", "l": "TLE oligomerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43964", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25610", "l": "beta-D-allofuranose => beta-D-allopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5339535", "l": "GLTPD1 transports C1P from plasma membrane to Golgi membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005246", "l": "calcium channel regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22396", "l": "1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 = glycolaldehyde + guaiacol + H2O + vanillin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58000", "l": "(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose = (20S)-ginsenoside Rg3 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68954", "l": "Mcm2-7 is phosphorylated by DDK (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948063", "l": "hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63682", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + 2 H(+) => (7R,8S)-7,8-diammoniononanoate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-448958", "l": "Nuclear translocation of p38 MAPK (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18063", "l": "methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin => 5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55722", "l": "17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate => 17-(4-hydroxyphenyl)heptadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65521", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => all-trans-3-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388468", "l": "AVP(20-28) binds AVPR1A,B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220964", "l": "NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49965", "l": "5,10-dihydrophenazine + O2 => H2O2 + phenazine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18388", "l": "acetone + 2 ATP + 3 H2O + hydrogencarbonate <=> acetoacetate + 2 AMP + 4 H(+) + 4 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34249", "l": "1-deoxymethyl-3-dehydrosphinganine + H(+) + NADPH => 1-deoxymethyl-sphinganine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39992", "l": "(4R)-hydroxyeicosasphinganine + a fatty acyl-CoA => CoA + H(+) + N-acyl-4-hydroxyeicosasphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22823", "l": "3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose <=> 3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59518", "l": "H(+) + N(6)-acetyl-L-lysyl-[protein] + salicylate => acetylsalicylate + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134962", "l": "DHX36 binds DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31191", "l": "(3S)-hydroxydecanoyl-CoA = (2E)-decenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986939", "l": "MECP2 binds the NCoR/SMRT complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25835", "l": "1D-chiro-inositol + NAD(+) <=> H(+) + NADH + scyllo-inosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31070", "l": "6-amino-2-oxohexanoate <=> Delta(1)-piperideine-2-carboxylate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66351", "l": "3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + A <=> (2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001591", "l": "dopamine neurotransmitter receptor activity, coupled via Gi/Go"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0046812", "l": "host cell surface binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44267", "l": "eicosanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-nonadecylpyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49067", "l": "2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol <=> calcitetrol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690740", "l": "CD22 binds B-cell receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66818", "l": "2 Na(+)(out) + tetrahydroxoborate(out) => 2 Na(+)(in) + tetrahydroxoborate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52073", "l": "12-(9Z-hexadecenoyloxy)-octadecanoate + H2O => (9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33895", "l": "NAD(+) + trans,octa-cis-decaprenylphospho-beta-D-arabinofuranose = H(+) + NADH + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose"}, {"i": "EC:1.1.1.333", "l": "\"Decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49739", "l": "2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate <=> CO2 + deoxyviolacein + 2 H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.n2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113402", "l": "Formation of DSIF:NELF:early elongation complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9607224", "l": "Active FLT3:GRB2:p-Y-GAB2 binds PIK3R1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-517846", "l": "TLR2-1 :TLR1-1 binds to triacyl lipopeptide (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-178208", "l": "SMAD7 binds to SMURF2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53412", "l": "(1R,4S)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 = (4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981657", "l": "IL34 dimer binds PTPRZ1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23933", "l": "an N-acyl-D-glucosamine 6-phosphate => an N-acyl-D-mannosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46021", "l": "[pyruvate, water dikinase] + ADP => [pyruvate, water dikinase]-phosphate + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033463", "l": "GGA codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396370", "l": "VTN binds collagens II, III and V (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693598", "l": "ATM phosphorylates NBN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806610", "l": "Keratin filament formation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22678", "l": "7(1)-hydroxychlorophyllide a + H2O + NADP(+) => chlorophyllide a + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022396", "l": "MME:Zn2+ hydrolyses AGT(34-43) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64141", "l": "an N-(fatty acyl)-L-asparagine + H2O => a fatty acid + L-asparagine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061799", "l": "cyclic pyranopterin monophosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43476", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 = 10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033795", "l": "betaine reductase activity"}, {"i": "RHEA:11848", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine = [thioredoxin]-dithiol + glycine betaine + H(+) + phosphate"}, {"i": "EC:1.21.4.4", "l": "\"Betaine reductase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004040", "l": "amidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706350", "l": "FLT3 phosphorylates CBL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "79.682896251205548", "identifiers": [{"i": "GO:0099106", "l": "ion channel regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018758", "l": "RHOH binds effectors at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507875", "l": "Aquaporins passively transport urea into cells (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17261", "l": "a phenyl sulfate + H2O = a phenol + H(+) + sulfate"}, {"i": "EC:3.1.6.1", "l": "\"Arylsulfatase (type I)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005137", "l": "interleukin-5 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798372", "l": "ATM phosphorylates DYRK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029272", "l": "Release of PLCG from FCGR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1471314", "l": "HNP1-3 bind CD4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62167", "l": "beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + H2O <=> D-glucosamine + N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102661", "l": "homogentisate solanyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004572", "l": "mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity"}, {"i": "RHEA:56052", "l": "2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = 2 alpha-D-mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]"}, {"i": "EC:3.2.1.114", "l": "\"Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9667965", "l": "ANKLE2 binds PP2A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43686", "l": "AMP + diphosphate + H(+) + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] => ATP + L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64145", "l": "H2O + N-(9Z-octadecenoyl)-L-methionine => (9Z)-octadecenoate + L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047716", "l": "imidazole N-acetyltransferase activity"}, {"i": "KEGG.REACTION:R03621"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990935", "l": "splicing factor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43487", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070080", "l": "titin Z domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.15"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23875", "l": "(R)-propane-1,2-diol + NAD(+) <=> (R)-lactaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909726", "l": "Phosphorylation of STAT1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54840", "l": "H(+) + NADPH + O2 + octan-3-one = H2O + NADP(+) + pentyl propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55081", "l": "ADP-alpha-D-glucose + D-fructose => ADP + H(+) + sucrose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614605", "l": "Persulfide sulfur is dioxygenated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682769", "l": "LGI2 binds ADAM22,23 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981926", "l": "RAC1 and CDC42 activate PAK3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35242", "l": "tetracycline(in) <=> tetracycline(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3781941", "l": "WNTs are secreted in exosomes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176175", "l": "Stalling of DNA replication fork and RPA binding (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57297", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O => a 2'-deoxyguanosine in DNA + glycolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19767", "l": "3-hydroxypropanal + H2O => glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12114", "l": "(R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + S-adenosyl-L-homocysteine => indole-3-pyruvate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59677", "l": "D-maltotetraose + O2 => D-maltotetraono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607722", "l": "Active NIK phosphorylates IKKA dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39074", "l": "dodecanedioyl-CoA + O2 <=> (2E)-dodecenedioyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018452", "l": "5-exo-hydroxycamphor dehydrogenase activity"}, {"i": "RHEA:32879", "l": "(1R,4R,5R)-5-hydroxycamphor + NAD(+) = (1R,4R)-bornane-2,5-dione + H(+) + NADH"}, {"i": "EC:1.1.1.327", "l": "\"5-exo-hydroxycamphor dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51602", "l": "3-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + m-xylene + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450187", "l": "TAK1 is activated within the TAK1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20476", "l": "(R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] <=> (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33850", "l": "H2O + N-tetracosanoyl-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + tetracosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13614", "l": "beta-D-fructose 6-phosphate + diphosphate => beta-D-fructose 1,6-bisphosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451634", "l": "NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28601", "l": "H2O + N-acetyl-L-lysine <=> acetate + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59840", "l": "(6S)-5,6,7,8-tetrahydrofolate + syringate = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-O-methylgallate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65604", "l": "(4R)-hydroxysphinganine + eicosanoyl-CoA = CoA + H(+) + N-eicosanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009072", "l": "STAT3 phosphorylation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190519", "l": "Internalization of gap junction plaques (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32697", "l": "(-)-car-3-ene + diphosphate => (2E)-geranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44585", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-(1'-sn-glycerol)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047851", "l": "dicarboxylate-CoA ligase activity"}, {"i": "RHEA:14289", "l": "a dicarboxylate + ATP + CoA = AMP + diphosphate + omega-dicarboxyl-CoA"}, {"i": "EC:6.2.1.23", "l": "\"Dicarboxylate--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19667", "l": "6-carboxyhex-2-enoyl-CoA + H(+) + NADH => 6-carboxyhexanoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60873", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O => a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(7)-methyl-GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811508", "l": "ING2-bound EP300 acetylates TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033781", "l": "cholesterol 24-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373738", "l": "Neurofascin interacts with syntenin-1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49009", "l": "aurachin C + H(+) + NADPH + O2 => aurachin C epoxide + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64418", "l": "D-xylono-1,4-lactone + H(+) + NADPH => D-xylofuranose + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15335", "l": "H(+) + N-carbamoyl-2-oxoglycine + NADPH => (S)-ureidoglycolate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15002", "l": "keto-L-sorbose + NADP(+) => 5-dehydro-D-fructose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022065", "l": "DSPGs are secreted (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30247", "l": "2 H2O + 4 hnu + 2 plastoquinone-9 = O2 + 2 plastoquinol-9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12437", "l": "(E)-caffeoyl-CoA + putrescine => CoA + H(+) + N-caffeoylputrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610653", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors bind to postsynaptic density proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3780997", "l": "PPP1R3C binds to glycogen:GYG2:GYS2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44426", "l": "CoA + H(+) + N-acyl-heptadecasphing-4-enine => a fatty acyl-CoA + heptadecasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15737", "l": "cyclopentanone + H(+) + NADPH + O2 = 5-valerolactone + H2O + NADP(+)"}, {"i": "EC:1.14.13.16", "l": "\"Cyclopentanone monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689972", "l": "USP2 deubiquitinates MDM2,MDM4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9646468", "l": "mTORC1 binds RHEB:GTP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27887", "l": "2',3'-cyclic AMP + H2O => 3'-AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53462", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z)-eicosatrienoate => 1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033956", "l": "beta-apiosyl-beta-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26098", "l": "(4R)-limonene + H(+) + NADPH + O2 => H2O + limonene 1,2-epoxide + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805059", "l": "CK2:FACT phosphorylates TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42323", "l": "a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O <=> a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59991", "l": "cyclohexane-1-carbonyl-CoA + NADP(+) <=> cyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190829", "l": "Lysosomal degradation of gap junction plaques (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164519", "l": "RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31094", "l": "acetyl-CoA + dodecanoyl-CoA <=> 3-oxotetradecanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49755", "l": "2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate <=> CO2 + 2 H2O + NAD(+) + proviolacein"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265301", "l": "Corticotropin cleavage from POMC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59454", "l": "a long-chain fatty aldehyde + H(+) + NADPH => a long-chain primary fatty alcohol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41013", "l": "(+)-sesamin monocatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) => (+)-sesamin + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609274", "l": "Active FLT3 binds HCK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031687", "l": "A2A adenosine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66469", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O => (17E)-cheilanthenediol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42165", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2 => (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20319", "l": "1-pyrroline-2-carboxylate + H(+) + NADPH => L-proline + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62378", "l": "(S)-lactate + H(+) + pyruvate => 2,4-didehydro-3-deoxy-L-rhamnonate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39488", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA => (2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59960", "l": "N(alpha)-acetyl-D-methionine = N(alpha)-acetyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018746", "l": "RHOQ binds effectors at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66325", "l": "iodide(out) => iodide(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848873", "l": "PTK6 phosphorylates ARAP1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37702", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730836", "l": "Interaction of BCL10:MALT1 with CARMA1 to form CBM complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17330", "l": "(1R,2S,4R)-borneol + NAD(+) => (1R,4R)-camphor + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166869", "l": "TRAF6 binds MEKK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6790038", "l": "Expression of HSP90B1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38196", "l": "androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004919", "l": "interleukin-9 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419428", "l": "S1PR2-5 bind S1P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61884", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-9-hydroperoxy-20-hydroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12054", "l": "diphosphate + trichodiene => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102151", "l": "3-oxo-myristate decarboxylase activity"}, {"i": "MetaCyc:RXN-11669"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-166387", "l": "The FA anion diffuses away laterally from UCP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18795", "l": "D-ribose 5-phosphate => alpha-D-ribose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9640195", "l": "RRAGA,B hydrolyzes GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41533", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41684", "l": "1-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine + H2O = 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389941", "l": "SHP-1 and SHP-2 bind pBTLA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57874", "l": "CoA + umbelliferone => (E)-2,4-dihydroxycinnamoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416516", "l": "GRK2 sequesters activated Gq (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61982", "l": "NADP(+) + ubiquinol-10 => H(+) + NADPH + ubiquinone-10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5681980", "l": "ATG12 binds ATG7 dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10493", "l": "H2O + phosphocholine => choline + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617454", "l": "HOXB1 gene is transcribed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420688", "l": "GABAB heterodimeric receptor binds GABA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879942", "l": "The receptor is activated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018832", "l": "halohydrin hydrogen-halide-lyase B activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55779", "l": "all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate <=> 4-hydroxy-4-O-(beta-D-glucuronide)-all-trans-retinoate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390673", "l": "CHRM2,4 bind acetylcholine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33298", "l": "L-hexahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-9-(methylsulfanyl)nonanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27331", "l": "5-hydroxyisourate + H2O + NAD(+) => H(+) + NADH + O2 + urate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954182", "l": "ERBB4s80:TAB2:NCOR1 complex binds S100B gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20588", "l": "loganin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + secologanin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33045", "l": "(+)-6-exo-hydroxycamphor + H2O + NADP(+) => (1R,4R)-camphor + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781840", "l": "ERCC6 binds stalled RNA Pol II (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34840", "l": "4 H(+) + 5 malonyl-CoA => 5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO2 + 5 CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17967", "l": "(8Z,11Z,14Z)-heptadecatrienal + CO2 + H2O => (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629918", "l": "NEIL1 translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6804100", "l": "HMGB1 binds LPS (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390912", "l": "HRH1 binds hist (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10621", "l": "(E)-cinnamaldehyde + CoA + NADP(+) => (E)-cinnamoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12232", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+) = [thioredoxin]-dithiol + glycine + H(+) + phosphate"}, {"i": "EC:1.21.4.2", "l": "\"Glycine reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3814820", "l": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31951", "l": "9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-dien-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.111", "l": "\"9-beta-pimara-7,15-diene oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2530445", "l": "CD59 inhibits MAC formation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14634", "l": "ATP + H2O + Na(+)(in) => ADP + H(+) + Na(+)(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034738", "l": "lanosterol O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56323", "l": "a 5-hydroxy anthocyanidin + UDP-alpha-D-glucose <=> an anthocyanin 5-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35149", "l": "(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(out) => (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34040", "l": "2-oxoglutarate + neamine => 6'-oxoparomamine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25312", "l": "glycolate + O2 => glyoxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54243", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23272", "l": "an N(6)-alkylaminopurine + UDP-alpha-D-glucose = an N(6)-alkylamino-7-beta-D-glucosylpurine + H(+) + UDP"}, {"i": "EC:2.4.1.118", "l": "\"Cytokinin 7-beta-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38077", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254291", "l": "ERBB4s80 binds STAT5A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685319", "l": "CX3 complex formation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34694", "l": "(R)-lactoyl-CoA <=> acryloyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58124", "l": "(19S)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + polyneuridine aldehyde"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018668", "l": "3-hydroxybenzoate 4-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0042085", "l": "5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937807", "l": "SRC phosphorylates RUNX3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54191", "l": "H2O + N-acetyl-L-phenylalanine <=> acetate + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44227", "l": "16-hydroxyhexadecanoate + ATP + CoA <=> 16-hydroxyhexadecanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18908", "l": "H2O + phosphonoacetaldehyde <=> acetaldehyde + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6795290", "l": "TORC2 complex phosphorylates SGK1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158357", "l": "factor XIIa binds SERPING1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170978", "l": "p-FRS2:CRKL binds C3G (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25070", "l": "3-hydroxybenzoate + ATP + CoA = 3-hydroxybenzoyl-CoA + AMP + diphosphate"}, {"i": "EC:6.2.1.37", "l": "\"3-hydroxybenzoate--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66672", "l": "4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) = 5,7-dihydroxy-4-methylphthalide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034590", "l": "L-hydroxyproline transmembrane transporter activity"}, {"i": "REACT:R-HSA-6784213", "l": "Unknown hydroxyproline carrier transports cytosolic HPRO into the mitochondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173631", "l": "Activation of C1s (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664214", "l": "ATP2B1 (PMCA1) transports Ca2+ from the cytosol to the extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18132", "l": "2-oxoaldehyde + H2O + NADP(+) <=> a 2-oxocarboxylate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70272", "l": "PGM:Mg2+ isomerise G6P to G1P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61377", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O => 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38676", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39706", "l": "(2E,13Z)-eicosadienoyl-CoA + H(+) + NADPH <=> (13Z)-eicosenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16978", "l": "acetoacetate + coenzyme M + NADP(+) => 2-oxopropyl-coenzyme M + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55564", "l": "4-hydroxytryptamine + ATP = 4-hydoxytryptamine 4-phosphate + ADP + H(+)"}, {"i": "EC:2.7.1.222", "l": "\"4-hydroxytryptamine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17497", "l": "formononetin + UDP-alpha-D-glucose = ononin + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120301", "l": "histone lactyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55781", "l": "all-trans-5,6-epoxyretinoate + UDP-alpha-D-glucuronate => all-trans-5,6-epoxyretinoyl-1-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13339", "l": "D-glucuronate + H(+) => D-glucurono-6,2-lactone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62777", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47943", "l": "ganglioside GM2 (d18:1(4E)) + H2O <=> ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9727349", "l": "XDH dehydrogenates xanthine to form urate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983194", "l": "Kinesin-1 is a heterotetramer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195733", "l": "M2 protein synthesis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198270", "l": "PDPK1 phosphorylates AKT at T308 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088281", "l": "Endorepellin binds KDR (VEGFR2) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001048", "l": "RNA polymerase IV core binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53351", "l": "5,6-dihydrouridine(20a) in tRNA + NAD(+) <=> H(+) + NADH + uridine(20a) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2395517", "l": "NADPH transfers electrons to FDXR (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33742", "l": "2 H(+) + hexadecanoate + NADH <=> H2O + hexadecanal + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604732", "l": "Autocatalytic activation of proMMP13 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9012835", "l": "GDIs block activation of RHOA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013435", "l": "RHOD auto-activates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420980", "l": "Activation of Ca permeable AMPA receptors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706308", "l": "Active FLT3 binds to GRB10 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47657", "l": "acetyl-CoA + L-methionine sulfone => CoA + H(+) + N-acetyl-L-methionine sulfone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102062", "l": "alpha-santalene synthase activity"}, {"i": "RHEA:30463", "l": "(2Z,6Z)-farnesyl diphosphate = (+)-alpha-santalene + diphosphate"}, {"i": "EC:4.2.3.50", "l": "\"(+)-alpha-santalene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54908", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH = (4E)-hexenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874080", "l": "SRC phosphorylates PTK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008449", "l": "N-acetylglucosamine-6-sulfatase activity"}, {"i": "REACT:R-HSA-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "62.58441683152963", "identifiers": [{"i": "GO:0016836", "l": "hydro-lyase activity"}, {"i": "REACT:R-HSA-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Homo sapiens)"}, {"i": "EC:4.2.1.-", "l": "\"Hydro-lyases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444523", "l": "CXCR5 binds CXCL13 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050021", "l": "L-arabinonolactonase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373867", "l": "BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49448", "l": "beta-D-Manp-(1->2)-beta-D-Manp-(1->2)-D-Manp + H2O = alpha-D-mannopyranose + beta-D-mannopyranosyl-(1->2)-D-mannopyranose"}, {"i": "EC:3.2.1.197", "l": "\"Beta-1,2-mannosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-481010", "l": "Surface deployment of platelet dense granule membrane components (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2559439", "l": "CD14:LPS binds CR3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033415", "l": "UGA codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693783", "l": "NAALADases hydrolyse NAAG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050023", "l": "L-fuconate dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51881", "l": "3,4,6-trichlorocatechol + O2 => (2Z,4E)-2,3,5-trichloromuconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857555", "l": "EGFR phosphorylates GPNMB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21890", "l": "(10Z,15Z)-12-oxophytodienoate + H(+) + NADPH => NADP(+) + OPC-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27696", "l": "(S)-3-methyl-2-oxopentanoate + H2O => (2R,3R)-2,3-dihydroxy-3-methylpentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62332", "l": "ADP + ATP = adenosine 3'-diphosphate,5'-diphosphate + AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964284", "l": "BTK in active Gq-BTK complex is activated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909720", "l": "IFN alpha/beta binds to IFNAR2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51085", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374701", "l": "Phosphorylation of DCC by Fyn (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849882", "l": "SALMs 1-4 bind reticulon 3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23922", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate => (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45049", "l": "acetamide + H2O => acetate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.71", "l": "\"Alcohol dehydrogenase (NAD(P)(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29745", "l": "2-phenylethylamine(out) => 2-phenylethylamine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164514", "l": "Integrase binds viral DNA ends (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0033721", "l": "aldehyde dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65118", "l": "aculene A + CO2 + H2O + succinate => 2-oxoglutarate + aculene B + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50863", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 <=> 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59567", "l": "H2O + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone <=> H(+) + N,N',N'',N'''-tetraacetylchitotetraonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20618", "l": "L-galactono-1,4-lactone + O2 => H(+) + H2O2 + L-ascorbate"}]}
{"type": "biolink:MolecularActivity", "ic": "75.582117822819498", "identifiers": [{"i": "GO:0004030", "l": "aldehyde dehydrogenase [NAD(P)+] activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018766", "l": "RHOU binds effectors at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56495", "l": "hederagenin + O2 + reduced [NADPH--hemoprotein reductase] <=> gypsogenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.62", "l": "\"Caspase-9\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685242", "l": "CHEK1 phosphorylates BRCA2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21189", "l": "ATP + deamido-NAD(+) + NH4(+) => AMP + diphosphate + H(+) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193981", "l": "CYP21A2 oxidises 17HPROG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0009931", "l": "calcium-dependent protein serine/threonine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112392", "l": "Resumption of elongation after recovery from pausing (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60263", "l": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851888", "l": "MET binds SHC1-2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-392834", "l": "Activation of EPACs by cAMP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209227", "l": "Activated Phospho IRD5:KEY dimer phosphorylates REL in the PGN:PGRP-LC oligomer receptor 'signalling complex' (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805122", "l": "AURKB binds TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034889", "l": "endosulfan hemisulfate sulfatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2089971", "l": "Secretion of collagens (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004445", "l": "inositol-polyphosphate 5-phosphatase activity"}, {"i": "EC:3.1.3.56", "l": "\"Inositol-polyphosphate 5-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35578", "l": "(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] <=> (1'S,5'R)-5'-hydroxyaverantin + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47764", "l": "S-adenosyl-L-methionine + uridine(1369) in 16S rRNA = 2'-O-methyluridine(1369) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.3", "l": "\"Gastricsin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424484", "l": "Phosphorylation of BTK by p-SYK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51454", "l": "beta-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + ursodeoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57613", "l": "20 H(+) + holo-[compactin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH => 9 CO2 + 9 CoA + dihydro-ML-236C-[compactin nonaketide synthase] + 6 H2O + 11 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018855", "l": "2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity"}, {"i": "RHEA:33419", "l": "[(1R)-2,2,3-trimethyl-2-oxocyclopent-3-en-1-yl]acetate + ATP + CoA = [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate"}, {"i": "EC:6.2.1.38", "l": "\"(2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668417", "l": "cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20446", "l": "L-arogenate + oxaloacetate => L-aspartate + prephenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218836", "l": "PTK2beta binds alphaVbeta3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614605", "l": "Persulfide sulfur is dioxygenated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944233", "l": "Association of procollagen type XIX (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866851", "l": "CFTR transits to the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090624", "l": "endoribonuclease activity, cleaving miRNA-paired mRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.25"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.22"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21288", "l": "D-glucose + sn-glycerol 3-phosphate = D-glucose 6-phosphate + glycerol"}, {"i": "EC:2.7.1.142", "l": "\"Glycerol-3-phosphate--glucose phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42035", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52995", "l": "[deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + [eIF5A protein]-L-lysine <=> [deoxyhypusine synthase]-L-lysine + [eIF5A protein]-N-(4-aminobutylidene)-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450325", "l": "c-FOS activation by phospho ERK1/2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103000", "l": "UDP-glucose:4-hydroxylamino-2,6-dinitrotoluene-O-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-9748"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45592", "l": "H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1254251", "l": "ERBB4s80 binds YAP1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34759", "l": "ATP + glycerol 2-phosphate(out) + H2O = ADP + glycerol 2-phosphate(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41377", "l": "1-O-decyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-decyl-sn-glycero-3-phosphocholine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29476", "l": "(2E,6E)-farnesyl diphosphate => (+)-cubenene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42061", "l": "11-cis-retinol + NAD(+) => 11-cis-retinal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31471", "l": "beta-D-gentiobiosyl crocetin + UDP-alpha-D-glucose = beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP"}, {"i": "EC:2.4.1.271", "l": "\"Crocetin glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35660", "l": "an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + GDP-alpha-D-mannose => GDP + H(+) + mannosylinositol phosphorylphytoceramide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050197", "l": "phytanate-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2395517", "l": "NADPH transfers electrons to FDXR (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28335", "l": "dATP + H2O => dAMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20547", "l": "3-hydroxy-L-kynurenine + H2O + NADP(+) => H(+) + L-kynurenine + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33727", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxyhexacosanoyl)-sphinganine = a 1,2-diacyl-sn-glycerol + Ins-1-P-Cer(d18:0/2-OH-26:0)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4755479", "l": "SUMOylation of NFKB2 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58886", "l": "A + chloramphenicol + 2 H2O => AH2 + alpha-N-dichloroacetyl-p-aminophenylserinol + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41896", "l": "(2E)-tetradecenoyl-[ACP] + H(+) + NADPH = NADP(+) + tetradecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050412", "l": "cinnamate beta-D-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247839", "l": "Retromer associates with WLS (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44425", "l": "a fatty acyl-CoA + heptadecasphing-4-enine => CoA + H(+) + N-acyl-heptadecasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033810", "l": "anthocyanin 5-O-glucoside 6'''-O-malonyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-912727", "l": "CBL binds VAV (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372697", "l": "Crk binding to p130cas (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071815", "l": "intermediate-density lipoprotein particle binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75238", "l": "TRAIL binds TRAIL receptors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30889", "l": "7,8-dihydropteroate + H2O => 4-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005537", "l": "mannose binding"}, {"i": "REACT:R-HSA-947991", "l": "Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56915", "l": "(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + H2O + NAD(+) <=> (E)-2-((N-methylformamido) methylene)succinate + 3 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-372542", "l": "Loading of dopamine into synaptic veiscles (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31175", "l": "(2E)-2-methylpropenoyl-CoA + H2O = (S)-3-hydroxyisobutanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389381", "l": "Gads binds CD28 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5626549", "l": "IQGAPs bind CALM1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31254", "l": "(S)-3-hydroxyisobutanoyl-CoA + H2O <=> (S)-3-hydroxy-2-methylpropanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909738", "l": "SHP1 and SHP2 bind the common beta chain (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63650", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20207", "l": "cycasin + H(+) + UDP => methylazoxymethanol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56724", "l": "AH2 + all-trans-beta-carotene + O2 = 4-hydroxy-all-trans-beta-carotene + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983152", "l": "Transfer of ubiquitin from E1 to E2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62711", "l": "(indol-3-yl)butanoate + UDP-alpha-D-glucose <=> 4-(indol-3-yl)butanoyl-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65658", "l": "25-hydroxycholest-1,4-dien-3-one + AH2 => A + cholest-1,4-dien-3-one + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21320", "l": "A + D-sorbitol = AH2 + keto-L-sorbose"}, {"i": "EC:1.1.99.21", "l": "\"D-sorbitol dehydrogenase (acceptor)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848338", "l": "PNPLA4 hydrolyzes TAG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11262", "l": "H2O2 + NADP(+) => H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75856", "l": "Abortive Initiation Before Second Transition (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70272", "l": "PGM:Mg2+ isomerise G6P to G1P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10874", "l": "a carboxylate + L-aspartate => H2O + N-acyl-L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809309", "l": "MTMR6 binds MTMR9 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983061", "l": "TSLP binds CRLF2:IL7R (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102294", "l": "cholesterol dehydrogenase activity"}, {"i": "MetaCyc:RXN-12693"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49194", "l": "1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419334", "l": "Melatonin receptors can bind melatonin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33395", "l": "H2O + N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester = GMP + N(alpha)-acetyl-L-lysine methyl ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30147", "l": "FADH2 + NAD(+) = FAD + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34459", "l": "8-hydroxycopalyl diphosphate + H2O = diphosphate + sclareol"}, {"i": "EC:4.2.3.141", "l": "\"Sclareol synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140692", "l": "very long-chain fatty acid omega-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58236", "l": "L-tyrosyl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428510", "l": "ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29916", "l": "L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose => alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52867", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24299", "l": "(S)-dihydroorotate + H2O <=> H(+) + N-carbamoyl-L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130706", "l": "MHC class II antigen processing (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42041", "l": "ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose => gangliosideFuc-GM1 (d18:1(4E)) + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45742", "l": "5-hydroxyectoine + CO2 + succinate => 2-oxoglutarate + L-ectoine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39946", "l": "a 1-acylglycerol + an acyl-CoA <=> a 1,2-diacylglycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32295", "l": "2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH = 2 diphosphate + NADP(+) + squalene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12868", "l": "1-methyladenosine + H2O <=> 1-methyladenine + D-ribose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202969", "l": "Caspase mediated cleavage of beta-catenin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42262", "l": "3-oxononanoyl-[ACP] + CO2 + CoA => H(+) + heptanoyl-CoA + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30995", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoradiol = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + soyasapogenol B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050315", "l": "synephrine dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28614", "l": "(1Z,2S)-2-methylbutanal oxime = (2S)-2-methylbutanenitrile + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017118", "l": "lipoyltransferase activity"}, {"i": "RHEA:20473", "l": "(R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983148", "l": "Interaction of Erp57 with MHC class I HC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57391", "l": "(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] <=> (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38006", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H(+) + homogentisate <=> 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444661", "l": "HCAR2 binds HCAR2 ligands (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004488", "l": "methylenetetrahydrofolate dehydrogenase (NADP+) activity"}, {"i": "RHEA:22812", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH"}, {"i": "EC:1.5.1.5", "l": "\"Methylenetetrahydrofolate dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210290", "l": "Interaction of PECAM-1 and SHIP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30209", "l": "formaldehyde + 2 H(+) + NH4(+) + 2 reduced [amicyanin] => H2O + methylamine + 2 oxidized [amicyanin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59176", "l": "ADP + L-serine = AMP + H(+) + O-phospho-L-serine"}, {"i": "EC:2.7.1.226", "l": "\"L-serine kinase (ADP)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59593", "l": "ATP + beta-alanine + L-arginine => ADP + beta-alanyl-L-arginine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51779", "l": "4-prenylphlorisobutanophenone + dimethylallyl diphosphate <=> deoxycohumulone + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45309", "l": "H(+) + NADPH + prostaglandin D2-ethanolamide => 11beta-prostaglandin F2-ethanolamide + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66565", "l": "histamine + L-glutaminyl-[protein] => 5-histaminyl-L-glutamyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32107", "l": "3-methoxy-4',5-dihydroxy-trans-stilbene + S-adenosyl-L-methionine = H(+) + pterostilbene + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38681", "l": "ADP + H(+) + phosphate + sphinganine(out) => ATP + H2O + sphinganine(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0090599", "l": "alpha-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54099", "l": "N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936631", "l": "sulfate uptake in the cytosol (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9681375", "l": "KIT binds ripretinib (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33940", "l": "H(+) + L-arginine + NADH + O2 => H2O + N(omega)-hydroxy-L-arginine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26525", "l": "(2S,3S)-2-methylcitrate <=> 2-methyl-trans-aconitate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46326", "l": "3-oxochola-4,17-dien-22-oyl-CoA + AH2 => 3-oxochol-4-en-22-oyl-CoA + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56469", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 bromide + 3 FADH2 + 3 O2 => (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 FAD + 6 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473594", "l": "Collagen type II degradation by MMP15 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004142", "l": "diacylglycerol cholinephosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53775", "l": "chenodeoxycholate + lithocholoyl-CoA <=> chenodeoxycholoyl-CoA + lithocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11140", "l": "alpha-D-mannose 1-phosphate = D-mannose 6-phosphate"}, {"i": "EC:5.4.2.8", "l": "\"Phosphomannomutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17454", "l": "5-phospho-beta-D-ribosylamine + ATP + glycine => ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3095889", "l": "MMACHC reduces Cbl (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65524", "l": "9-cis-retinal + O2 + reduced [NADPH--hemoprotein reductase] = 9-cis-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27967", "l": "7,8-dihydroneopterin 3'-triphosphate + H2O => 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614614", "l": "Cysteine is degraded to serine and H2S (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47121", "l": "docosanoate + glycine => H2O + N-docosanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43815", "l": "1,2-dioctadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-452100", "l": "SHC1 bound to IL2 receptor is phosphorylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55377", "l": "2 a quinol + O2 => 2 a quinone + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140761", "l": "sequestered tissue factor -> tissue factor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448963", "l": "Interaction of MyoD:E protein with MEF2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928602", "l": "NGEF binds EPHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8847880", "l": "CYTH proteins bind ARF1:GTP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62737", "l": "1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + dimethylallyl diphosphate => 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2399913", "l": "atRAL binds to RBP2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42120", "l": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17091", "l": "D-glyceraldehyde 3-phosphate + pyruvate => 2-dehydro-3-deoxy-6-phospho-D-gluconate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031774", "l": "leukotriene receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013009", "l": "RHOA binds effectors at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444527", "l": "FPR is a receptor for formyl peptides (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36261", "l": "an aldehyde + glycerol => a 1-(1-hydroxyalkyl)-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004423", "l": "iduronate-2-sulfatase activity"}, {"i": "REACT:R-HSA-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865491", "l": "RUNX1:CBFB:KMT2A binds SPI1 (PU.1) gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63228", "l": "ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13146", "l": "4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate => alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11065", "l": "beta-D-fructose 1,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802911", "l": "High kinase activity BRAF complexes phosphorylate MAP2Ks (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694462", "l": "ABHD6,12 hydrolyse 3AG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27724", "l": "4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP => di-trans,octa-cis-undecaprenyl phosphate + UDP-4-deoxy-4-formamido-beta-L-arabinose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042021", "l": "granulocyte macrophage colony-stimulating factor complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44096", "l": "decan-1-ol + hexadecanoyl-CoA = CoA + decanyl hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191072", "l": "Synthesis of Cx43 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433395", "l": "Dimerization of sSCF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59360", "l": "carnosine + H2O = beta-alanine + L-histidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878054", "l": "HIPK2 phosphorylates RUNX1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050610", "l": "methylarsonate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31168", "l": "(3S)-hydroxytetradecanoyl-CoA + NAD(+) => 3-oxotetradecanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12060", "l": "acetyl-CoA + 5 H(+) + 6 malonyl-CoA = 3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + 6 CO2 + 7 CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46960", "l": "butanoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = (2E)-butenoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.3.1.109", "l": "\"Butanoyl-CoA dehydrogenase complex (NAD(+), ferredoxin)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "76.711710297129045", "identifiers": [{"i": "GO:0042379", "l": "chemokine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39181", "l": "eicosanoyl-CoA + NADP(+) => (2E)-eicosenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31211", "l": "ATP + H2O + L-selenomethionine = diphosphate + L-adenosylselenomethionine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201629", "l": "Caspase-mediated cleavage of Tau (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18483", "l": "cyclohexylamine + sulfate => cyclohexylsulfamate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5607746", "l": "PKC-delta is activated (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37370", "l": "CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine <=> 2,3-bis-O-phytanyl-sn-glycero-3-phospho-L-serine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.24"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218832", "l": "CDC42:GTP binds PAK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59906", "l": "2 H(+) + NADPH + octanoate => H2O + NADP(+) + octanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702583", "l": "crenolanib-resistant FLT3 mutants don't bind crenolanib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.15", "l": "\"Nitrite reductase (NADH)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043717", "l": "2-hydroxyglutaryl-CoA dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800793", "l": "PIDD1 translocates to the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46027", "l": "H2O2 + tetradecanoate <=> (3R)-hydroxytetradecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371518", "l": "SIRT1 binds to HSF1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53733", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminosalicylate => 2-hydroxy-7,8-dihydropteroate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12400", "l": "beta-nicotinamide D-ribonucleotide + H2O = NH4(+) + nicotinate beta-D-ribonucleotide"}, {"i": "EC:3.5.1.42", "l": "\"Nicotinamide-nucleotide amidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030585", "l": "phosphoenolpyruvate carboxykinase (diphosphate) activity"}, {"i": "KEGG.REACTION:R00346"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203130", "l": "OLR1 binds to oxidized LDL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62473", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-nonadioyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18350", "l": "ATP + L-aspartate + tRNA(Asx) => AMP + diphosphate + L-aspartyl-tRNA(Asx)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296127", "l": "Activation of voltage gated Potassium channels (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047658", "l": "alpha-amino-acid esterase activity"}, {"i": "RHEA:17241", "l": "an alpha-amino acid ester + H2O = an alcohol + an alpha-amino acid + H(+)"}, {"i": "EC:3.1.1.43", "l": "\"Alpha-amino-acid esterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49313", "l": "2-trans,4-trans-xanthoxin + NAD(+) => 2-trans-(+)-abscisic aldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047007", "l": "pregnan-21-ol dehydrogenase (NAD+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40416", "l": "H2O + pristanoyl-CoA => 2,6,10,14-tetramethylpentadecanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42347", "l": "H(+) + NADH + O2 + p-cumate <=> (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432607", "l": "VRI replaces PDP1 as binder to Clk and cry genes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49482", "l": "H(+) + L-2-aminoadipate + NADPH => 2 H2O + L-1-piperideine-6-carboxylate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10139", "l": "2 glyoxylate + H(+) <=> 2-hydroxy-3-oxopropanoate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656212", "l": "Phosphorylation of RAF1 mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2752115", "l": "SPP1 (osteopontin) binds CD44 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22123", "l": "CoA + GTP + succinate <=> GDP + phosphate + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106301", "l": "arachidonic acid 5,6-epoxygenase activity"}, {"i": "RHEA:49936", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64584", "l": "2-hydroxyethane-1-sulfonate(out) + Na(+)(out) = 2-hydroxyethane-1-sulfonate(in) + Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19930", "l": "[(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004018", "l": "N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26222", "l": "abieta-7,13-dien-18-ol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-oate + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40200", "l": "hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432188", "l": "AVP:AVPR2 Complex binds inactive heterotrimeric G(s) complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58439", "l": "4-methylpentan-1-ol + NADP(+) <=> 4-methylpentanal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72671", "l": "eIF5B:GTP is hydrolyzed and released (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "62.237471741347221", "identifiers": [{"i": "GO:0003723", "l": "RNA binding"}, {"i": "REACT:R-HSA-203922", "l": "Exportin-5 recognizes 3' overhang of pre-miRNA  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61483", "l": "a sphingoid base + a very long-chain fatty acyl-CoA <=> an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27782", "l": "4-hydroxybenzoate + all-trans-octaprenyl diphosphate = 4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22679", "l": "chlorophyllide a + H(+) + NADPH + O2 <=> 7(1)-hydroxychlorophyllide a + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50692", "l": "ADP-alpha-D-glucose + alpha-D-glucose 1-phosphate = ADP + alpha-maltose 1-phosphate + H(+)"}, {"i": "EC:2.4.1.342", "l": "\"Alpha-maltose-1-phosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446372", "l": "Association of  PARVA with TESK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003837", "l": "beta-ureidopropionase activity"}, {"i": "REACT:R-HSA-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40326", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417843", "l": "P2Y13 binds ADP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.99.-", "l": "\"With other acceptors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55092", "l": "D-fructose + UDP-alpha-D-glucose = H(+) + sucrose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54241", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000433", "l": "SUMOylation of PML with SUMO3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13899", "l": "prephenate => chorismate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296326", "l": "HCAR1 binds LACT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3858475", "l": "ppDVL recruits RAC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49183", "l": "a bacteriochlorophyllide d + S-adenosyl-L-methionine <=> a bacteriochlorophyllide c + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112429", "l": "Formation of FACT complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44512", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1793217", "l": "Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0008097", "l": "5S rRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32198", "l": "abieta-7,13-dien-18,18-diol <=> abieta-7,13-dien-18-al + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59048", "l": "D-ornithine + H(+) = CO2 + putrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20702", "l": "ADP + H(+) + lipid IVA (E. coli) => ATP + lipid A disaccharide (E. coli)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36401", "l": "5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH => 5alpha-cholest-8-en-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28979", "l": "H(+)(out) + nitrite(in) = H(+)(in) + nitrite(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57590", "l": "(2S)-2-hydroxynaringenin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17055", "l": "beta-D-fructose 6-phosphate + D-erythrose 4-phosphate => D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627107", "l": "XIAP binds CASP7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40571", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197588", "l": "NICD2 binds RBPJ and MAML in the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417842", "l": "P2Y10 receptor can bind to LPA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44064", "l": "hexadecanoyl-CoA + octan-1-ol = CoA + octyl hexadecanoyl"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42882", "l": "H(+) + N(4)-aminopropylspermine + S-methyl-5'-thioadenosine => S-adenosyl 3-(methylsulfanyl)propylamine + spermine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59047", "l": "dammarenediol-II + UDP-alpha-D-glucose <=> (20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674385", "l": "p-T,Y MAPKs dimerize (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54140", "l": "cytidine(49) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(49) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12964", "l": "acetoacetate + butanoyl-CoA <=> acetoacetyl-CoA + butanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39971", "l": "1-aminocyclopropane-1-carboxylate = 2-aminobut-2-enoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4093331", "l": "Ras:GTP binds p120-RasGAP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.-", "l": "\"Protein-serine/threonine kinases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37906", "l": "6-hydroxytryprostatin B + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + tryprostatin A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42078", "l": "2-hydroxyglutaryl-CoA + acetate => 2-hydroxyglutarate + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-205136", "l": "GTP-bound RAC contributes to JNK activation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0019775", "l": "FAT10 transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23690", "l": "hypoxanthine + NH4(+) => adenine + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36599", "l": "hydrogen sulfide + NAD(+) = NADH + sulfur"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.2.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373074", "l": "Receptor CCR9  binds CCL25 ligand (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098625", "l": "methylselenol reductase activity"}, {"i": "REACT:R-HSA-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56244", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = 2-hexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl hexadecanoate + apo--[retinol-binding protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15363", "l": "dolichyl D-xylosyl phosphate + UDP => dolichyl phosphate + UDP-alpha-D-xylose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30042", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADPH + O2 <=> benzene-1,2,4-triol + CO2 + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33528", "l": "acetyl-CoA + ergosta-5,7,22,24(28)-tetraen-3beta-ol => CoA + ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847534", "l": "RAB43 hydrolyses GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38634", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120153", "l": "calcium-dependent carbohydrate binding"}]}
{"type": "biolink:MolecularActivity", "ic": "80.155824608458104", "identifiers": [{"i": "GO:0032452", "l": "histone demethylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51221", "l": "1-chloro-2,4-dinitrobenzene + glutathione => 2,4-dinitrophenyl-S-glutathione + chloride + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46558", "l": "2 [Fe(III)-cytochrome b5] + cholesta-5,7-dien-3beta-ol + 2 H2O => 5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2245218", "l": "CDK1 phosphorylates PHF8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36452", "l": "ATP + glycyl-L-glutamate(out) + H2O => ADP + glycyl-L-glutamate(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.73"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40231", "l": "(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24449", "l": "enterobactin + UDP-alpha-D-glucose => monoglucosyl-enterobactin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035167", "l": "NR1H2,3 binds the EEPD1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60617", "l": "N-dodecanoyl-heptadecasphing-4-enine-1-phosphoethanolamine => ethanolamine + N-dodecanoyl-heptadecasphing-4-enine-1,3-cyclic phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29089", "l": "menaquinol-8 + oxaloacetate => (S)-malate + menaquinone-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15024", "l": "(E)-feruloyl-CoA + L-quinate <=> 4-O-feruloyl-D-quinate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0030882", "l": "lipid antigen binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58458", "l": "(R)-glycerate + D-mannose => (2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9679044", "l": "FKBP1A binds sirolimus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48530", "l": "ganglioside GQ1c (d18:1(4E)) + N-acetylneuraminate => ganglioside GP1c (d18:1(4E)) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.213", "l": "\"Galactan exo-1,6-beta-galactobiohydrolase (non-reducing end)\""}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0002054", "l": "nucleobase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388596", "l": "Melanocortin receptors bind melanocortins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8940134", "l": "FOLR2 binds FOLA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33185", "l": "citrate(out) => citrate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44083", "l": "ATP + CoA + undecanoate <=> AMP + diphosphate + undecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15496", "l": "A + H2O + N2 <=> AH2 + nitrous oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6790038", "l": "Expression of HSP90B1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32742", "l": "1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9690461", "l": "FKBP1A binds tacrolimus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227867", "l": "TANK binds polyubiquitinated TRAF3/6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21399", "l": "(S)-methylmalonyl-CoA + H(+)(out) + Na(+)(in) <=> CO2 + Na(+)(out) + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.49", "l": "\"[Pyruvate kinase]-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.1.3", "l": "\"Hydrogen dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.63", "l": "\"Caspase-10\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53788", "l": "allodeoxycholoyl-CoA + beta-muricholate = allodeoxycholate + beta-muricholoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090417", "l": "N-methylnicotinate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0031846", "l": "neurotensin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40410", "l": "1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41582", "l": "5,10-dihydro-9-dimethylallylphenazine 1-carboxylate + diphosphate => 5,10-dihydrophenazine 1-carboxylate + dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034886", "l": "gamma-aminovinylacetate deaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63076", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA = 2-acetylphloroglucinol + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49515", "l": "2-(phosphinatomethylidene)butanedioate + H2O <=> phosphinomethylisomalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1614591", "l": "Excess cysteine yields lanthionine and H2S (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17081", "l": "S-adenosyl-L-methionine + trans-isoeugenol = H(+) + S-adenosyl-L-homocysteine + trans-isomethyleugenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.14", "l": "\"Actinidain\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209891", "l": "Dopamine is oxidised to noradrenaline (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805122", "l": "AURKB binds TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29488", "l": "(2E,6E)-farnesyl diphosphate => cis-muurola-3,5-diene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55793", "l": "butan-2-one + H(+) + NADH + O2 => 1-hydroxy-2-butanone + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404134", "l": "RBP4:atROL binds TTR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37246", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372723", "l": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] <=> phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64388", "l": "4 A + sn-3-O-phytanylglycerol 1-phosphate = 4 AH2 + sn-3-O-(geranylgeranyl)glycerol 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40616", "l": "H2O + tridecanoylglycerol => 2,3-didecanoyl-sn-glycerol + decanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610732", "l": "GSK3 phosphorylates p-GLI3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22268", "l": "ATP + streptomycin = ADP + H(+) + streptomycin 6-phosphate"}, {"i": "EC:2.7.1.72", "l": "\"Streptomycin 6-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51343", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> 10-hydroperoxy-(4Z,7Z,11E,13Z,16Z,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25173", "l": "H2O + N(omega)-methyl-L-arginine = L-citrulline + methylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40447", "l": "(2R)-pristanoyl-CoA = (2S)-pristanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21954", "l": "H(+) + NADPH + progesterone => 5alpha-pregnane-3,20-dione + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983259", "l": "Kinesins move along microtubules consuming ATP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71287", "l": "phosphocreatine + H2O => creatinine + orthophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873917", "l": "Translocation of STAT1 dimer to nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047373", "l": "acetoxybutynylbithiophene deacetylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994020", "l": "IRF1 binds the promoters of Interferon alpha and beta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.130"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676589", "l": "RANKL,sRANKL trimer binds RANK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23631", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19939", "l": "H(+) + S-adenosyl-L-homocysteine + sarcosine => glycine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61477", "l": "a sphingoid base + octadecanoyl-CoA => an N-octadecanoyl-sphingoid base + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045517", "l": "interleukin-20 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45009", "l": "H2O + N-(octadecanoyl)-sphinganine => octadecanoate + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51657", "l": "keto-D-tagaturonate => keto-D-fructuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.21"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41758", "l": "1-O-methyl-(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => 1-O-methyl-(9Z,12Z)-octadecadienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448632", "l": "IL34 dimerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40389", "l": "1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+) => 1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41195", "l": "1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0003707", "l": "steroid hormone receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29487", "l": "(2E,6E)-farnesyl diphosphate = cis-muurola-3,5-diene + diphosphate"}, {"i": "RHEA:29491", "l": "(2E,6E)-farnesyl diphosphate = cis-muurola-4(14),5-diene + diphosphate"}, {"i": "EC:4.2.3.67", "l": "\"Cis-muuroladiene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797810", "l": "PTPRD binds IL1RAPL1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004339", "l": "glucan 1,4-alpha-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29116", "l": "H(+) + menaquinone-8 + NADPH => menaquinol-8 + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042924", "l": "neuromedin U binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635918", "l": "Expression of CEBPB in response to stress (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191072", "l": "Synthesis of Cx43 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-481007", "l": "Exocytosis of platelet alpha granule contents (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30165", "l": "germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + NADPH => germacra-1(10),4,11(13)-trien-12-al + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17660", "l": "an acyl-CoA + dihydroxyacetone phosphate <=> a 1-acylglycerone 3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22957", "l": "1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35939", "l": "brevianamide F + dimethylallyl diphosphate = diphosphate + tryprostatin B"}, {"i": "EC:2.5.1.106", "l": "\"Tryprostatin B synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047014", "l": "glycerol-3-phosphate 1-dehydrogenase [NADP+] activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102515", "l": "pelargonidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity"}, {"i": "MetaCyc:RXN-14447"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209910", "l": "Iodide is taken up by thyroid epithelial cells (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59224", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + hydropyrene"}, {"i": "EC:4.2.3.201", "l": "\"Hydropyrene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59650", "l": "D-xylotrionate + H(+) => D-xylotriono-1,5-lactone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30880", "l": "H2O + NAD(+) + prop-2-ynal => 2 H(+) + NADH + propynoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12221", "l": "H2O + L-leucine + NAD(+) => 4-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448957", "l": "Interaction of p38 MAPK with JLP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013435", "l": "RHOD auto-activates (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661820", "l": "Bacterial GUSB hydrolyses BDG to BIL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429860", "l": "DCP1-DCP2 complex decaps mRNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21068", "l": "A + H2O + nitrite = AH2 + nitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634228", "l": "TRAF1 is cleaved by caspases (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982765", "l": "Growth hormone forms dimers and oligomers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16817", "l": "6-phospho-D-gluconate + NADP(+) = 6-phospho-2-dehydro-D-gluconate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4088281", "l": "Endorepellin binds KDR (VEGFR2) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38760", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174959", "l": "The acetyl group from acetyl-CoA is transferred to the NAT1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712187", "l": "GNAL:GTP (G alpha-olf) binds ADCY3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183067", "l": "Localization of CBL:GRB2 to the membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030172", "l": "troponin C binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18360", "l": "NADP(+) + tropine <=> H(+) + NADPH + tropinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205244", "l": "Recruitment of CBL to KIT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35750", "l": "(2E,6E)-farnesyl diphosphate <=> 7-epizingiberene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662669", "l": "Dopaquinone transforms to Leucodopachrome (Cyclodopa) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70982", "l": "Fumarate + H2O <=> (S)-Malate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23720", "l": "ATP + hydrogencarbonate + propanoyl-CoA = (S)-methylmalonyl-CoA + ADP + H(+) + phosphate"}, {"i": "EC:6.4.1.3", "l": "\"Propionyl-CoA carboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36619", "l": "2-hydroxydocosanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxydocosanoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54244", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58473", "l": "2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + O2 => CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37548", "l": "D-glucose 6-phosphate + NAD(+) => 3-dehydro-D-glucose 6-phosphate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10800", "l": "diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine"}, {"i": "EC:2.4.2.22", "l": "\"Xanthine phosphoribosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62155", "l": "dGMP + dTTP <=> dGDP + dTDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56397", "l": "[(3R)-hydroxybutanoate](n) + H2O => (3R)-hydroxybutanoate trimer + [(3R)-hydroxybutanoate](n-3) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53627", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + tsukubadiene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65317", "l": "2-oxoglutarate + chrodrimanin H + O2 => chrodrimanin E + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047883", "l": "ethanolamine oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177934", "l": "EGFR autophosphorylation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77068", "l": "Activation of GT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010091", "l": "APP translocates from plasma membrane to endosome lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38427", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18457", "l": "D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)"}, {"i": "EC:4.1.99.12", "l": "\"3,4-dihydroxy-2-butanone-4-phosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74718", "l": "Internalisation of the insulin receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5221061", "l": "TDG excises 5-carboxylcytosine (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013009", "l": "RHOA binds effectors at the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11878", "l": "15-oxoprostaglandin E2 + H(+) + NADH => NAD(+) + prostaglandin E2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807578", "l": "GNLY binds the bacterial cell surface in the phagosome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794351", "l": "SHARPIN binds SHANK proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64480", "l": "4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate = (1S,3R,6R,8R,9R,11R,14S,15S,19R,20R)-8-ethyl-9,15-dihydroxy-3,4,6,20-tetramethyl-21,23-dioxo-24-azapentacyclo[20.2.1.0(1,6).0(11,20).0(14,19)]pentacosa-4,12,22(25)-trien-25-olate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54779", "l": "1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine <=> [LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44805", "l": "1,4-dihydroxy-2-naphthoate + all-trans-nonaprenyl diphosphate + H(+) => 2-demethylmenaquinol-9 + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610717", "l": "PKA phosphorylates GLI2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43422", "l": "1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35163", "l": "H(+)(out) + minocycline(in) = H(+)(in) + minocycline(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51049", "l": "5alpha-androstan-3,17-dione + A => AH2 + androst-4-ene-3,17-dione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199456", "l": "PTEN dephosphorylates PIP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187211", "l": "Splicing of HIV RNA transcript (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19474", "l": "4-hydroxybenzoate + H(+) + NADH + O2 => 3,4-dihydroxybenzoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5632677", "l": "PTCH is internalized (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202164", "l": "Translocation of PDK1 to Plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59967", "l": "L-seryl-[protein] + octanoyl-CoA <=> CoA + O-octanoyl-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451418", "l": "Pellino ubiquitinates IRAK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14129", "l": "cholate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH"}, {"i": "EC:1.1.1.176", "l": "\"12-alpha-hydroxysteroid dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10251", "l": "dUTP + H2O <=> diphosphate + dUMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9667914", "l": "ALK binds ligand midkine (MDK) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66479", "l": "gypsogenate + UDP-alpha-D-glucose <=> gypsogenate 28-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700184", "l": "Ligand-independent dimerization of point mutants of ALK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6811427", "l": "COPI vesicle uncoating at the ER (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814094", "l": "ARL1:GTP binds ARFIP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58319", "l": "beta-D-glucosyl-N-hexadecanoylsphing-4E-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5620918", "l": "ASAP1 dimer binds membrane proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004130", "l": "cytochrome-c peroxidase activity"}, {"i": "RHEA:16581", "l": "2 [Fe(II)cytochrome c] + 2 H(+) + H2O2 = 2 [Fe(III)cytochrome c] + 2 H2O"}, {"i": "EC:1.11.1.5", "l": "\"Cytochrome-c peroxidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003692", "l": "left-handed Z-DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59384", "l": "2-oxoglutarate + 4-amino-L-phenylalanine = 3-(4-aminophenyl)pyruvate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46356", "l": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50202", "l": "(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60021", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + sesquisabinene A"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004316", "l": "3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"}, {"i": "MetaCyc:RXN-10659"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247840", "l": "WLS binds WNT ligands in the Golgi (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19443", "l": "3-hydroxy-cis,cis-muconate + 2 H(+) => benzene-1,2,4-triol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59385", "l": "2-oxoglutarate + 4-amino-L-phenylalanine => 3-(4-aminophenyl)pyruvate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428749", "l": "Activated TP receptor binds G-proten Gq (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39515", "l": "(2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH = (15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60799", "l": "2 2-oxoglutarate + gibberellin A53 + H(+) + 3 O2 <=> 3 CO2 + gibberellin A20 + 2 H2O + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35705", "l": "(2S,3S)-versiconal hemiacetal acetate + H2O + NADP(+) => 1'-hydroxyversicolorone + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381608", "l": "cAMP activates EPAC2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58801", "l": "3',3'-cGAMP + H2O => 5'-pApG-3' + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013158", "l": "CDC42 GDIs block activation of CDC42 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102535", "l": "ladanein 6-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-14752"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165680", "l": "Formation of active mTORC1 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47847", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) <=> CO2 + diphosphate + thiamine phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604731", "l": "Autocatalytic activation of MMP3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54521", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => cycloaraneosene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40380", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019799", "l": "tubulin N-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005141", "l": "interleukin-10 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11645", "l": "a (2R,3R)-flavan-3-ol + 2 NADP(+) => an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21909", "l": "NADP(+) + scytalone => H(+) + NADPH + naphthalene-1,3,6,8-tetrol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851352", "l": "CCR8 binds CCL1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63723", "l": "losartan + UDP-alpha-D-glucuronate <=> losartan-2-N-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031962", "l": "mineralocorticoid receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24888", "l": "D-glutamate + H(+) + NADH => (R)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27929", "l": "UMP(in) <=> UMP(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976723", "l": "Serum amyloid P-component forms homopentamers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55297", "l": "13-cis-retinol + hexadecanoyl-CoA => 13-cis-retinyl hexadecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66037", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ATP + H2O => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61814", "l": "dehydroepiandrosterone 3-beta-D-glucoside + H(+) + UDP => 3beta-hydroxyandrost-5-en-17-one + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47034", "l": "2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein] => AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57466", "l": "1-O-[(E)-caffeoyl]-beta-D-glucose + UDP => (E)-caffeate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0042389", "l": "omega-3 fatty acid desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110244", "l": "Excision of FapyG by OGG1 glycosylase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47526", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => cholate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11973", "l": "4 Fe(2+) + 6 H2O + O2 => 12 H(+) + 4 iron(III) oxide-hydroxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17432", "l": "NAD(+) + trans-4-hydroxycyclohexanecarboxylate <=> 4-oxocyclohexanecarboxylate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3159259", "l": "MMAA:MUT binds AdoCbl (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20616", "l": "3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine <=> adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43736", "l": "adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.266", "l": "\"23S rRNA (adenine(2030)-N(6))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034547", "l": "N-cyclopropylmelamine deaminase activity"}, {"i": "MetaCyc:RXN-8018"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65584", "l": "(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] = 8-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592371", "l": "Initial activation of proMMP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444433", "l": "Cho transports from the extracellular space to the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63438", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + a di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H(+) => 1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418845", "l": "Activation of caspase-3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-398040", "l": "Gbeta:gamma activation of PLC beta (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62902", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-GlcNAc + GDP + H(+) => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203613", "l": "depalmitoylation of eNOS (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11381", "l": "2-oxoglutarate + [2-(trimethylamino)ethyl]phosphonate + O2 => [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158357", "l": "factor XIIa binds SERPING1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25855", "l": "2 [Fe(II)-cytochrome b5] + an 11,12-saturated fatty acyl-CoA + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + an (11Z)-Delta(11)-fatty acyl-CoA + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2032781", "l": "WWTR1 (TAZ) binds TEAD (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46975", "l": "A + dihydrobisanhydrobacterioruberin <=> AH2 + bisanhydrobacterioruberin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22645", "l": "O2 + protopine + reduced [NADPH--hemoprotein reductase] => 6-hydroxyprotopine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804741", "l": "MDM2 forms homo- or heterodimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36369", "l": "2-hydroxyglutarate + H(+) => (S)-alpha-hydroxyglutarate-gamma-lactone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174121", "l": "Association of Securin with Cdc20:APC/C complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375151", "l": "Interaction of NCAM1 with collagens (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48526", "l": "ganglioside GQ1c + N-acetylneuraminate => ganglioside GP1c + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57022", "l": "ADP + apulose 4-phosphate + H(+) => apulose + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56866", "l": "(2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + 6 CoA + 4 H2O + NAD(+) + 5 NADP(+) => 12 H(+) + 6 malonyl-CoA + NADH + 5 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43623", "l": "L-serine + NADP(+) <=> aminoacetaldehyde + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696670", "l": "CHD1L is recruited to GG-NER site (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856525", "l": "ANGPTL8 binds ANGPTL3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35960", "l": "H(+) + NADPH + O2 + tryprostatin B => demethoxyfumitremorgin C + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693061", "l": "STAMBP binds STAM (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981713", "l": "C4b binds to cell surface (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61157", "l": "3'-dephospho-CoA + GTP => CoA + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052734", "l": "shikimate 3-dehydrogenase (NAD+) activity"}, {"i": "RHEA:17741", "l": "NAD(+) + shikimate = 3-dehydroshikimate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686430", "l": "MUS81 binds EME1, EME2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199298", "l": "AKT phosphorylates CREB1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66246", "l": "diphosphate + IC-asc-C9-AMP => ATP + H(+) + IC-asc-C9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48451", "l": "H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide <=> beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29700", "l": "dimethyl sulfoxide(in) => dimethyl sulfoxide(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54483", "l": "1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038200", "l": "ethylene receptor histidine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20054", "l": "NAD(+) + ribitol => D-ribulose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73932", "l": "Resynthesis of excised residue by POLB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58346", "l": "D-glucose + lithocholate => beta-D-glucosyl-(1->3)-O-lithocholate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29895", "l": "ATP + H2O + L-glutamine(out) = ADP + H(+) + L-glutamine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.18"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11562", "l": "catechol + CO2 + NADH => (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31496", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000411", "l": "RANBP2 SUMOylates PML with SUMO2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106320", "l": "(R)-limonene 1,2-monooxygenase NADPH activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21333", "l": "acetyl-CoA + D-glucosamine => CoA + H(+) + N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20310", "l": "2 H2O2 => 2 H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49880", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.133", "l": "\"N(alpha)-acyl-L-glutamine aminoacylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22124", "l": "17-O-acetylajmaline + H2O = acetate + ajmaline + H(+)"}, {"i": "RHEA:23796", "l": "17-O-acetylnorajmaline + H2O = acetate + H(+) + norajmaline"}, {"i": "EC:3.1.1.80", "l": "\"Acetylajmaline esterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57134", "l": "(2R)-1-(4-hydroxyphenyl)-2-aminoethanol + H2O + L-dehydroascorbate => L-ascorbate + O2 + tyramine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016019", "l": "peptidoglycan immune receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14050", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4,11-diene => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905054", "l": "calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium ion concentration"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371435", "l": "Constitutive phosphorylation by GSK3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.6.-", "l": "\"With an nitrogenous group as acceptor\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102583", "l": "cyanidin 3-O-glucoside-(2''-O-xyloside) 6''-O-acyltransferase activity"}, {"i": "MetaCyc:RXN-15329"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2468040", "l": "Cohesin binds PDS5 and WAPAL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047796", "l": "cyclohexane-1,3-dione hydrolase activity"}, {"i": "RHEA:16473", "l": "cyclohexane-1,3-dione + H2O = 5-oxohexanoate + H(+)"}, {"i": "EC:3.7.1.10", "l": "\"Cyclohexane-1,3-dione hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009910", "l": "IL37(?-218) binds p-S423,S425-SMAD3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44274", "l": "4-hydroxy-6-(2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA => 3 H(+) + 3 malonyl-CoA + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-449117", "l": "TXLNA (IL14) binds syntaxin1A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57761", "l": "2 (S)-methylmalonyl-CoA + 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH => C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45315", "l": "NADP(+) + prostaglandin F2alpha <=> H(+) + NADPH + prostaglandin H2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58282", "l": "cyclic tetraadenylate + 4 diphosphate => 4 ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14696", "l": "dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56040", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3) = beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53452", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + a cholesterol ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.-", "l": "\"Serine-type carboxypeptidases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400143", "l": "Fatty acid ligands activate PPARA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23440", "l": "4-chlorobenzoate + H2O = 4-hydroxybenzoate + chloride + H(+)"}, {"i": "EC:3.8.1.6", "l": "\"4-chlorobenzoate dehalogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23190", "l": "3-hydroxypropanal + H(+) + NADH => NAD(+) + propane-1,3-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60925", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2 => CO2 + formaldehyde + L-lysyl-[protein] + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052923", "l": "all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity"}, {"i": "KEGG.REACTION:R09250"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62689", "l": "4 norrubrofusarin + O2 => 2 H2O + 2 ustilaginoidin A"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000341", "l": "RNA trimethylguanosine cap binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5662613", "l": "MT3 exchanges zinc for copper (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033959", "l": "deoxyribodipyrimidine endonucleosidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015351", "l": "bilirubin secondary active transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102619", "l": "oryzalexin C synthase (oryzalexin A dependent) activity"}, {"i": "MetaCyc:RXN-15467"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46520", "l": "2 [Fe(II)-cytochrome b5] + an N-(1,2 saturated acyl)-(4R)-hydroxysphinganine + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + an N-(2R-hydroxyacyl)-4R-hydroxysphinganine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-983152", "l": "Transfer of ubiquitin from E1 to E2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33615", "l": "ATP + CoA + octadecanoate = AMP + diphosphate + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51033", "l": "7-chloroindole-3-pyruvate imine dimer => dichlorochromopyrrolate + H(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9677579", "l": "CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46720", "l": "(3R)-hydroxyhexanoyl-CoA = (2E)-hexenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18590", "l": "[glutamine synthetase]-L-tyrosine + ATP => [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604499", "l": "Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696131", "l": "AOC1 deaminates Hist (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381644", "l": "ER calcium channels open in response to activated PKA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852337", "l": "GTSE1 binds TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58753", "l": "1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0003905", "l": "alkylbase DNA N-glycosylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57169", "l": "(R)-2-hydroxyglutarate + FAD + H(+) => 2-oxoglutarate + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130349", "l": "Generation of CLIP from lip10 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008265", "l": "Mo-molybdopterin cofactor sulfurase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853792", "l": "RET tyrosine phosphorylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379464", "l": "COMT transfers Met to DOPAC to form HVA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75079", "l": "Formation of AT-AC C complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51970", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate => (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168860", "l": "Membrane fusion (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41147", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64372", "l": "beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O = alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + N-acetyl-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37454", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + eicosanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52504", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 9(R)-hydroxy-(10E,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21329", "l": "cholesterol + O2 => cholest-4-en-3-one + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951951", "l": "RUNX3 binds EP300 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12936", "l": "L-fuculose 1-phosphate <=> (S)-lactaldehyde + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22141", "l": "a nucleoside 5'-phosphate + H2O => a nucleoside + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19051", "l": "(5R)-5-phosphooxy-L-lysine + GDP + H(+) => (5R)-5-hydroxy-L-lysine + GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12166", "l": "a phenyl sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + a phenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610760", "l": "GLI1 is degraded by the proteasome after ubiquitination by ITCH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50506", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein] => acetyl-CoA + N-terminal L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45918", "l": "4-hydroxy-6-(13-hydroxy-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA => 12-hydroxyoctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0016454", "l": "C-palmitoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9681616", "l": "AP2 binds chlorpromazine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55925", "l": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] => albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53638", "l": "1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38367", "l": "8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA = 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA"}, {"i": "EC:2.3.1.260", "l": "\"Tetracycline polyketide synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429694", "l": "CERT:PPM1L:VAPA/B [ER] => CERT [cytosol] + PPM1L:VAPA/B [ER] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29209", "l": "a menaquinone(in) + dimethyl sulfide(out) + H2O(out) => a menaquinol(in) + dimethyl sulfoxide(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682631", "l": "nsp13 binds DDX5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25688", "l": "L-cysteinyl-tRNA(Cys) + phosphate => H(+) + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099618", "l": "UDP-glucuronic acid dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48060", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60193", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59984", "l": "an N(2)-acyl-L-glutamine + H2O = a carboxylate + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15163", "l": "H2O + homogentisate + NAD(+) => 4-hydroxyphenylacetate + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854408", "l": "APOBR dimer binds VLDLs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851933", "l": "MET phosphorylates GAB1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2214324", "l": "Collagen type VII dimerization (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102145", "l": "(3R)-(E)-nerolidol synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48040", "l": "globoside Gb4Cer + H2O = globoside Gb3Cer + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174202", "l": "Degradation of multiubiquitinated Securin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005503", "l": "all-trans retinal binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74448", "l": "Calcium binds calmodulin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51908", "l": "dATP + H2O = dADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36829", "l": "D-glucose + diosgenin + 2 L-rhamnopyranose => dioscin + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-844438", "l": "NLRP1 oligomerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863463", "l": "STON2 binds SYT proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693347", "l": "CRYM reduces P2C to PPCA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430158", "l": "p-SLP-76 binds VAV (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8873929", "l": "Casein kinase II phosphorylates STARD10 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036443", "l": "dermatan 6-sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55085", "l": "(3R)-3-hydroxypentanoyl-CoA + H2O => (3R)-3-hydroxypentanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034936", "l": "4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9625482", "l": "PTK2 binds activated EGFR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44821", "l": "1,4-dihydroxy-2-naphthoate + all-trans-tridecaprenyl diphosphate + H(+) => 2-demethylmenaquinol-13 + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791155", "l": "Expression of EDEM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507871", "l": "Aquaporins passively transport glycerol out of cells (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61984", "l": "H(+) + NADH + ubiquinone-10 = NAD(+) + ubiquinol-10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24695", "l": "acetate + NADP(+) + trans-isoeugenol => (E)-coniferyl acetate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10727", "l": "GDP-6-deoxy-alpha-D-talose + NADP(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15432", "l": "heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421836", "l": "trans-Golgi Network Derived Vesicle Uncoating (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19965", "l": "S,S-dimethyl-beta-propiothetin = acrylate + dimethyl sulfide + H(+)"}, {"i": "EC:4.4.1.3", "l": "\"Dimethylpropiothetin dethiomethylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54009", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25546", "l": "diphosphate + ent-pimara-9(11),15-diene => ent-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45018", "l": "L-selenomethionine + tetrahydropteroyltri-L-glutamate => 5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2533944", "l": "Fibronectin degradation by MMP10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55196", "l": "2-hydroxyoctadecanoyl-CoA = formyl-CoA + heptadecanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45539", "l": "H2O + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-octadecanoyl ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50942", "l": "cyclo(L-phenylalanyl-L-leucyl) + H(+) + tRNA(Leu) + tRNA(Phe) => L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380203", "l": "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102647", "l": "D-ribose 5-phosphate:D-sedoheptulose 7-phosphate transaldolase activity"}, {"i": "MetaCyc:RXN-15789"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24261", "l": "(3E)-2-oxohex-3-enedioate + H(+) => 2-oxopent-4-enoate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786050", "l": "IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1299359", "l": "Activation of TALK (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8856223", "l": "B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.60", "l": "\"Glucan 1,4-alpha-maltotetraohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950766", "l": "IL27RA dimerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2586553", "l": "JAK2 Phosphorylates LEPR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031720", "l": "haptoglobin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44976", "l": "(R)-carnitine + propanoyl-CoA = CoA + O-propanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46873", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA => a 2-acyl-sn-glycero-3-phosphocholine + lipid IIB"}]}
{"type": "biolink:MolecularActivity", "ic": "66.553158422731826", "identifiers": [{"i": "GO:0008289", "l": "lipid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65986", "l": "lumisterol 3 => hnu + previtamin D3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54402", "l": "2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17712", "l": "4-hydroxybenzoate + all-trans-nonaprenyl diphosphate <=> 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39178", "l": "(3R)-hydroxyeicosanoyl-CoA <=> (2E)-eicosenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19990", "l": "S-methyl-5-thio-alpha-D-ribose 1-phosphate => S-methyl-5-thio-D-ribulose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:1990814", "l": "DNA/DNA annealing activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66675", "l": "4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) <=> 5,7-dihydroxy-4-methylphthalide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63947", "l": "a fatty acyl-CoA + sphinga-4E,14Z-dienine <=> an N-acyl-sphinga-4E,14Z-dienine + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36519", "l": "H(+) + hexacosanoyl-CoA + malonyl-CoA = 3-oxooctacosanyol-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54008", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33159", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)"}, {"i": "EC:3.1.4.54", "l": "\"N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43072", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = erythrodiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008918", "l": "lipopolysaccharide 3-alpha-galactosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29720", "l": "cob(I)alamin(in) => cob(I)alamin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.13", "l": "\"Clostridial aminopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685608", "l": "CLEC2B binds KLRF1 dimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140482", "l": "iron sensor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28631", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate = 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004357", "l": "glutamate-cysteine ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626981", "l": "TNF-alpha:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32889", "l": "2 all-trans-retinal => all-trans-beta-carotene + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004483", "l": "mRNA (nucleoside-2'-O-)-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8960973", "l": "RLBP1:11cRAL dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607740", "l": "PKC-delta phosphorylates CARD9 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31438", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-alpha-santalene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17736", "l": "acetylenedicarboxylate + H(+) + H2O <=> CO2 + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5221061", "l": "TDG excises 5-carboxylcytosine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160931", "l": "Disassembly of tight junctions (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30170", "l": "D-erythrose 4-phosphate + dihydroxyacetone phosphate <=> sedoheptulose 1,7-bisphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983156", "l": "Polyubiquitination of substrate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036102", "l": "Defective UGT1A1 does not transfer GlcA from UDP-GlcA to BMG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11213", "l": "indole + O2 => 2-formamidobenzaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44557", "l": "4-hydroxybenzoate + all-trans-hexaprenyl diphosphate => 4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71303", "l": "RPE dimers isomerise RU5P to XY5P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.154", "l": "\"Sterol 14-alpha-demethylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35990", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31486", "l": "soyasapogenol E + UDP-alpha-D-glucuronate <=> H(+) + soyasapogenol E 3-O-beta-D-glucuronate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801109", "l": "CHM binds RGGT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112271", "l": "The receptor:G-protein complex dissociates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46645", "l": "cortisol + H(+) + NADPH => 5beta-dihydrocortisol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55618", "l": "a carotenoid epsilon-end group => a carotenoid psi-end group"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58333", "l": "(E)-non-2-en-1-ol + NADP(+) => (E)-non-2-enal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964284", "l": "BTK in active Gq-BTK complex is activated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51208", "l": "20-hydroxy-leukotriene B4 + NADP(+) = 12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38804", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951486", "l": "CD46 binds C4b (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047159", "l": "1-alkenylglycerophosphocholine O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29443", "l": "H(+)(in) + L-alanine(in) = H(+)(out) + L-alanine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34138", "l": "cannabigerolate + O2 <=> Delta(9)-tetrahydrocannabinolate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37952", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0008534", "l": "oxidized purine nucleobase lesion DNA N-glycosylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33487", "l": "(4R)-hydroxysphinganine + 2-hydroxyhexacosanoyl-CoA = CoA + H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50360", "l": "(R)-mandelonitrile + O2 = benzoyl cyanide + H2O2"}, {"i": "EC:1.1.3.49", "l": "\"(R)-mandelonitrile oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66302", "l": "an alpha-D-mannosylinositol-1-phosphodihydroceramide + GDP + H(+) => an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66330", "l": "taurine(in) => taurine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374664", "l": "Phosphorylation and activation of Ezrin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53092", "l": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 2-hydroxy-3-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045442", "l": "deacetoxycephalosporin-C hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41480", "l": "an acyl-CoA + episterol = an episterol ester + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40496", "l": "N-[omega-(9Z,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine + O2 => N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004343", "l": "glucosamine 6-phosphate N-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64415", "l": "H(+)(out) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) <=> H(+)(in) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65492", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine = 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + CO2 + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54925", "l": "(7Z)-tetradecenoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxo-(9Z)-hexadecenoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51404", "l": "H2O + L-arginine + O2 = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)"}, {"i": "EC:1.4.3.25", "l": "\"L-arginine oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19989", "l": "S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate"}, {"i": "EC:5.3.1.23", "l": "\"S-methyl-5-thioribose-1-phosphate isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53769", "l": "allocholate + allodeoxycholoyl-CoA => allocholoyl-CoA + allodeoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013009", "l": "RHOA binds effectors at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65941", "l": "(R)-glycerate + GDP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41433", "l": "3-methyl-L-tyrosine + H2O2 => 5-hydroxy-3-methyl-L-tyrosine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052714", "l": "mannosyl-inositol phosphorylceramide phospholipase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10525", "l": "2-oxoglutarate + H(+) => CO2 + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0001025", "l": "RNA polymerase III general transcription initiation factor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950586", "l": "Expression of glutathione S-transferase alpha 2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2201322", "l": "TIRAP is phosphorylated by BTK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9658253", "l": "RAS:GTP binds PI3K (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39629", "l": "(2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H2O => (3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37248", "l": "H2O + thymidine 3'-monophosphate => phosphate + thymidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33393", "l": "C20 sphinganine + phosphate => C20 sphinganine 1-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174808", "l": "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1362465", "l": "GHBP binds GHR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62606", "l": "7-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1605768", "l": "Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-378956", "l": "Luteinizing hormone is a heterodimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33590", "l": "acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate <=> CoA + H(+) + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018654", "l": "2-hydroxy-phenylacetate hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61042", "l": "(+)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20717", "l": "H(+) + H2O + S-adenosyl-L-homocysteine => NH4(+) + S-inosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55855", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA <=> [(2->6)-alpha-D-glucosyl-(1->4)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853314", "l": "Activated FGFR3 fusions:p-FRS2 bind GRB2-SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004958", "l": "prostaglandin F receptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061690", "l": "lipoamidase activity"}, {"i": "MetaCyc:RXN-13031"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982637", "l": "Opsins binds G alpha-t (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58360", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 = (5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870465", "l": "RGGT binds the RAB-binding subunit (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093327", "l": "EPHA binds TIAM1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.98.-", "l": "\"With other, known, acceptors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51371", "l": "glycine + octadecanoyl-CoA <=> CoA + H(+) + N-octadecanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41193", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + propanoate => 1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.65", "l": "\"Macrophage elastase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12490", "l": "2-dehydro-3-deoxy-D-gluconate + NH4(+) => 2-amino-2-deoxy-D-gluconate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14485", "l": "(2E,6E)-farnesyl diphosphate + H2O = 10-epi-juneol + diphosphate"}, {"i": "EC:4.2.3.172", "l": "\"10-epi-juneol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806419", "l": "TP53 binds the FANCC gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198314", "l": "DAG stimulates protein kinase C-delta (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685156", "l": "ATR phosphorylates RPA2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676229", "l": "WIPIs bind PI3P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507719", "l": "p62:MEKK3 binds to TRAF6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381707", "l": "PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217152", "l": "Formation of a multi-protein complex, cohesin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706399", "l": "RHOBTB3 hydrolyzes ATP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24421", "l": "H2O + N-terminal N-formyl-L-methionyl-[peptide] => formate + N-terminal L-methionyl-[peptide]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26133", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "59.168112216598622", "identifiers": [{"i": "GO:0051213", "l": "dioxygenase activity"}, {"i": "REACT:R-HSA-112124", "l": "Oxidative demethylation of 3-meC damaged DNA By ALKBH3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4088130", "l": "PLK1 binds FOXM1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374723", "l": "Nociceptin receptor binds to nociceptin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13811", "l": "aspulvinone H + 2 diphosphate => aspulvinone E + 2 dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5689861", "l": "Recruitment of XPA and release of CAK  (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10521", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose => 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371353", "l": "Soluble TNF-alpha binds TNFR1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17137", "l": "prostaglandin H2 = thromboxane A2"}, {"i": "EC:5.3.99.5", "l": "\"Thromboxane-A synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474266", "l": "Formation of collagen fibrils (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465940", "l": "atRAL is reduced to atROL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31866", "l": "(S)-2,3-epoxysqualene <=> friedelin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40056", "l": "1,2,3-trioctanoylglycerol + H2O => 2,3-dioctanoyl-sn-glycerol + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20773", "l": "2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) => 5-amino-6-(D-ribitylamino)uracil + riboflavin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9674093", "l": "PDGFRs bind type I TKI (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50889", "l": "an N-acylsphingoid base 1-phosphate + H2O => an N-acyl-sphingoid base + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35094", "l": "anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine <=> 2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212651", "l": "Transport of L-Glutamine (cytosol) to mitochondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093329", "l": "EFNBs bind SDCBP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28491", "l": "H(+)(in) + K(+)(in) => H(+)(out) + K(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34380", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 UDP-alpha-D-galactofuranose => beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 H(+) + 2 UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036209", "l": "9beta-pimara-7,15-diene oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57653", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 => CMP + ganglioside GM1alpha + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211960", "l": "CYP2U1 19-hydroxylates ARA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055055", "l": "D-glucose:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11812", "l": "H2O + methanethiol + O2 = formaldehyde + H(+) + H2O2 + hydrogen sulfide"}, {"i": "EC:1.8.3.4", "l": "\"Methanethiol oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865276", "l": "PDGF-AB clevage by Furin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804253", "l": "MDM2 ubiquitinates JMY (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876484", "l": "NPC2 transfers CHOL to NPC1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31159", "l": "(3S)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801109", "l": "CHM binds RGGT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "76.412572999466406", "identifiers": [{"i": "GO:0016703", "l": "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53999", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37773", "l": "1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015599", "l": "ATPase-coupled L-glutamine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58797", "l": "a flavonol 7-O-beta-D-glucoside + malonyl-CoA => a flavonol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52336", "l": "a long-chain fatty acid + ATP + H(+) = a long-chain fatty acyl-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864433", "l": "TFAP2A,TFAP2C homodimers stimulate CGA gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205286", "l": "GRB2:SOS interacts with p-KIT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61253", "l": "H2O + L-valine + O2 => 3-methyl-2-oxobutanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31916", "l": "ATP + D-maltose => ADP + alpha-maltose 1-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20921", "l": "2,4-dichlorophenol + H(+) + NADPH + O2 => 3,5-dichlorocatechol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20658", "l": "4-chlorophenylacetonitrile + 2 H2O => 4-chlorophenylacetate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9613497", "l": "Unwinding DNA for the nascent transcript (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31917", "l": "ADP + alpha-maltose 1-phosphate + H(+) => ATP + D-maltose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47951", "l": "H2O + thiamine phosphate <=> phosphate + thiamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428625", "l": "Vesicular inhibitory amino acid transport (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050352", "l": "trimethylamine-oxide aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371518", "l": "SIRT1 binds to HSF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602458", "l": "Activation of proMMP10 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953398", "l": "PIR oxygenates quercetin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879562", "l": "SLCO2B1 has a narrow substrate specificity (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685605", "l": "SLAMF7 binds SLAMF7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071794", "l": "CAP-Gly domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24561", "l": "acetyl-CoA + L-serine => CoA + O-acetyl-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452122", "l": "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805730", "l": "SETD9 methylates TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29446", "l": "H(+)(in) + L-alanine(in) <=> H(+)(out) + L-alanine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-383190", "l": "HCO3- transport through ion channel (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53516", "l": "1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (11Z,14Z,17Z-eicosatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54091", "l": "3,4-dihydroxyphenylacetate + H(+) + NADH + O2 <=> 2,4,5-trihydroxyphenylacetate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36733", "l": "1-nitrocyclohexene + H(+) + NADPH => 1-nitrocyclohexan + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9671145", "l": "DKC1 binds SHQ1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681674", "l": "nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697018", "l": "Addition of sialic acids on some Spike glycosyl sidechains (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34052", "l": "2'''-acetyl-6'''-hydroxyneomycin C + H2O => 6'''-deamino-6'''-hydroxyneomycin C + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10354", "l": "acetate + an arylalkylamine => an N-acetylarylalkylamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61770", "l": "H(+) + rebaudioside D + UDP => rebaudioside A + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28715", "l": "(R)-malate(in) + 2 H(+)(in) = (R)-malate(out) + 2 H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28397", "l": "L-alanyl-L-glutamate <=> L-alanyl-D-glutamate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103072", "l": "straight chain (R)-2-hydroxy fatty acyl-CoA lyase activity"}, {"i": "MetaCyc:RXN66-475"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061899", "l": "11-cis-retinal 3,4-desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38988", "l": "nonanoyl-CoA + O2 => (2E)-nonenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0004567", "l": "beta-mannosidase activity"}, {"i": "MetaCyc:3.2.1.25-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0001064", "l": "single subunit type RNA polymerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36523", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617676", "l": "HOXA3 gene is transcribed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2467811", "l": "Separation of sister chromatids (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53539", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O <=> (13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141367", "l": "Myristoylation of tBID by NMT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35529", "l": "N-ethylsuccinimide + NAD(+) => H(+) + N-ethylmaleimide + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45818", "l": "AH2 + pyruvate => (S)-lactate + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58140", "l": "acetyl-AMP + cytidine(34) in elongator tRNA(Met) = AMP + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734730", "l": "ORC1 translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061598", "l": "molybdopterin adenylyltransferase activity"}, {"i": "RHEA:31331", "l": "ATP + H(+) + molybdopterin = adenylyl-molybdopterin + diphosphate"}, {"i": "EC:2.7.7.75", "l": "\"Molybdopterin adenylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008424", "l": "glycoprotein 6-alpha-L-fucosyltransferase activity"}, {"i": "MetaCyc:2.4.1.68-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32352", "l": "3 S-adenosyl-L-methionine + tricetin => 3',4',5'-O-trimethyltricetin + 3 H(+) + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57112", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55557", "l": "a hydroperoxyeicosatetraenoate => an oxoeicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112152", "l": "RNA Polymerase III Promoter Opening at Type 3 Promoters (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707586", "l": "FeHM oxidises LDL,HDL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5444511", "l": "Formation of MSH2:MSH3 Complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047012", "l": "sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26318", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate => 3-amino-4-hydroxybenzoate + H(+) + 2 H2O + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52967", "l": "hyodeoxycholate + UDP-alpha-D-glucuronate <=> H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29020", "l": "D-galactose(in) + H(+)(in) => D-galactose(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58369", "l": "(2E,6Z)-nona-2,6-dien-1-ol + NADP(+) => (2E,6Z)-nona-2,6-dienal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50989", "l": "prostaglandin F2alpha(out) => prostaglandin F2alpha(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36903", "l": "7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.290", "l": "\"tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372542", "l": "Loading of dopamine into synaptic veiscles (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19044", "l": "(25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> (25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31212", "l": "ATP + H2O + L-selenomethionine => diphosphate + L-adenosylselenomethionine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51445", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-leucine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011289", "l": "ZSWIM8 binds ROBO3.1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47070", "l": "4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 4alpha-formyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450348", "l": "Activated human JNKs migrate to nucleoplasm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090499", "l": "pimelyl-[acyl-carrier protein] methyl ester esterase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0008135", "l": "translation factor activity, RNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9649733", "l": "mature p21 RAS binds GDP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46934", "l": "5-epi-valiolone 7-phosphate => 2-epi-5-epi-valiolone 7-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83650", "l": "FasL:Fas binds FADD (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36799", "l": "a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17313", "l": "ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)"}, {"i": "EC:6.1.1.21", "l": "\"Histidine--tRNA ligase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102830", "l": "verbascose synthase activity"}, {"i": "MetaCyc:RXN-8286"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035804", "l": "structural constituent of egg coat"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5159250", "l": "ATF7IP binds SETDB1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36164", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate => ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19621", "l": "a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 3'-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21737", "l": "(3S)-3,6-diaminohexanoate => (3S,5S)-3,5-diaminohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696822", "l": "AKR1B15 reduces EST17b to E1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10622", "l": "(E)-cinnamoyl-CoA + H(+) + NADPH => (E)-cinnamaldehyde + CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11519", "l": "H2O + succinyl-CoA <=> CoA + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018334", "l": "Estrogen-responsive CXXC5 gene expresion (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51954", "l": "2-hydroxy-2-methylpropanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-2-methylpropanal oxime + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198813", "l": "GSTO dimers reduce DeHA to AscH- (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-372819", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21973", "l": "precorrin-1 + S-adenosyl-L-methionine => precorrin-2 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45623", "l": "H2O + N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-butanoyl ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46073", "l": "(2E)-hexadecenoyl-CoA + H(+) + NADH => hexadecanoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55495", "l": "ent-cassa-12,15-dien-2-one + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13045", "l": "ent-kaur-16-ene + O2 + reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030305", "l": "heparanase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6804100", "l": "HMGB1 binds LPS (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3782535", "l": "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55990", "l": "beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] => H2O + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16296", "l": "2-isopropylmaleate + H2O <=> (2S)-2-isopropylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36686", "l": "hexadecanoyl-CoA + L-cysteinyl-[protein] <=> CoA + S-hexadecanoyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624798", "l": "LBR binds KPNB1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47367", "l": "a dodecanoate ester + H2O <=> an aliphatic alcohol + dodecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-517705", "l": "p-S318,221-HuR binds mRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51737", "l": "L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141423", "l": "Binding of the MCC complex to the APC/C complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40104", "l": "H2O + propanoyl-CoA => CoA + H(+) + propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1449687", "l": "Corticosteroids bind to CBG in blood (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31558", "l": "(5S)-5-amino-3-oxohexanoate + acetyl-CoA <=> (3S)-3-aminobutanoyl-CoA + acetoacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46313", "l": "3-oxochol-4-en-22-oyl-CoA + acetyl-CoA => 3,22-dioxochol-4-en-24-oyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031876", "l": "secretin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25039", "l": "ADP + O-phospho-L-seryl-tRNA(Sec) => ATP + L-seryl-tRNA(Sec)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19911", "l": "2 [Fe(II)cytochrome c] + 2 H(+) + pyruvate => (S)-lactate + 2 [Fe(III)cytochrome c]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39039", "l": "an omega-oxo fatty acid + H2O + NAD(+) = a dicarboxylate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30798", "l": "2-oxoadipate + CoA + NAD(+) <=> CO2 + glutaryl-CoA + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451033", "l": "(S)-Malate <=> Fumarate + H2O (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33774", "l": "a 1,2-diacyl-sn-glycerol + CDP-N-methylethanolamine <=> 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57187", "l": "L-cysteinyl-[protein] + methylglyoxal <=> S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139917", "l": "tBID activates BAX protein (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35101", "l": "fusidate(out) + H(+)(in) => fusidate(in) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61860", "l": "dehydroprobetaenone I + H(+) + NADPH + O2 = epoxybetaenone + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14108", "l": "L-proline + NAD(+) <=> 1-pyrroline-5-carboxylate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31612", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene => H2O + rhodopin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45040", "l": "2 [Fe(III)cytochrome c] + hydroxylamine = 2 [Fe(II)cytochrome c] + 2 H(+) + nitroxyl"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102634", "l": "1,3,6,8-tetrahydroxynaphthalene monooxygenase (quinone-forming) activity"}, {"i": "MetaCyc:RXN-15586"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814088", "l": "SYS1 binds AcM-ARFRP1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634669", "l": "IMPACT binds GCN1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797974", "l": "LRRTMs bind NRXNs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52332", "l": "2 N(omega)-hydroxy-L-arginine + 2 O2 + reduced [flavodoxin] = 3 H(+) + 2 H2O + 2 L-citrulline + 2 nitric oxide + oxidized [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63366", "l": "(S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-1,3-oxazole-[protein] + H2O2 => (S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64630", "l": "CoA + octyl acetate => acetyl-CoA + octan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34465", "l": "cis-abienol + diphosphate => 8-hydroxycopalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30331", "l": "all-trans-beta-carotene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = all-trans-zeaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.15.24", "l": "\"Beta-carotene 3-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9007882", "l": "IL1F10 is cleaved (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607746", "l": "PKC-delta is activated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102048", "l": "indole-3-acetyl-isoleucine synthetase activity"}, {"i": "MetaCyc:RXN-10430"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390641", "l": "ADRA1A,B,D bind ADR,NAd (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56122", "l": "3-(all-trans-heptaprenyl)benzene-1,2-diol + H2O + NADP(+) => 2-all-trans-heptaprenylphenol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44300", "l": "2 H(+) + malonyl-CoA + methylmalonyl-CoA + octadecanoyl-CoA = 4-hydroxy-5-methyl-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551570", "l": "VANGL2 is phosphorylated in response to WNT5A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019148", "l": "D-cysteine desulfhydrase activity"}, {"i": "RHEA:11268", "l": "D-cysteine + H2O = H(+) + hydrogen sulfide + NH4(+) + pyruvate"}, {"i": "EC:4.4.1.15", "l": "\"D-cysteine desulfhydrase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59442", "l": "(S)-isodihydrodehydrodiconiferyl alcohol + NADP(+) => (-)-dehydrodiconiferyl alcohol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849055", "l": "PTK6 binds ARHGAP35 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19328", "l": "H(+) + NADH + O2 + quinolin-4-ol <=> H2O + NAD(+) + quinoline-3,4-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693599", "l": "Association of Ku heterodimer with ends of DNA double-strand break (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40083", "l": "hexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 26-hydroxyhexacosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2247510", "l": "MARCO:ligand is endocytosed (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084501", "l": "Collagen type VII binds collagen type IV (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28898", "l": "cadaverine(in) + L-lysine(out) <=> cadaverine(out) + L-lysine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418845", "l": "Activation of caspase-3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22616", "l": "2 H(+) + O2 + 2 sulochrin = 2 (2R)-bisdechlorogeodin + 2 H2O"}, {"i": "EC:1.21.3.5", "l": "\"Sulochrin oxidase ((-)-bisdechlorogeodin-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55265", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine => di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39599", "l": "3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705726", "l": "SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033520", "l": "TYSND1 cleaves TYSND1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29383", "l": "dIMP + H2O = 2'-deoxyinosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67027", "l": "a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine <=> a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43756", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]"}, {"i": "EC:2.3.1.266", "l": "\"[Ribosomal protein S18]-alanine N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65555", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O <=> an N-acyl-sphingoid base + lactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16381", "l": "L-arabinitol + NAD(+) = H(+) + L-xylulose + NADH"}, {"i": "EC:1.1.1.12", "l": "\"L-arabinitol 4-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28672", "l": "2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.35"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008694", "l": "3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005183", "l": "gonadotropin hormone-releasing hormone activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66601", "l": "2 dopamine + O2 => 2 dopamine quinone + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21435", "l": "(S)-malate + NAD(+) <=> H(+) + NADH + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37297", "l": "ADP + H(+) + L-alanyl-L-threonine(in) + phosphate => ATP + H2O + L-alanyl-L-threonine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22672", "l": "2 (2E,6E)-farnesyl diphosphate = diphosphate + presqualene diphosphate"}, {"i": "EC:2.5.1.103", "l": "\"Presqualene diphosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694421", "l": "PP6 dephosphorylates SEC24 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63973", "l": "A + dihydropyriculol => AH2 + pyriculol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036332", "l": "placental growth factor-activated receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18525", "l": "3-methylbutanol + NADP(+) = 3-methylbutanal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54632", "l": "2-oxoglutarate + O2 + tetradecanoyl-CoA = 2-hydroxytetradecanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57608", "l": "(1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+) = 3-chlorocatechol + H(+) + NADH"}, {"i": "EC:1.3.1.119", "l": "\"Chlorobenzene dihydrodiol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18327", "l": "(+)-amorpha-4,11-diene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55756", "l": "2-oxoglutarate + an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + O2 = a 2-hydroxyornithine lipid + CO2 + succinate"}, {"i": "EC:1.14.11.58", "l": "\"Ornithine lipid ester-linked acyl 2-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112342", "l": "Inactivation of MAP2K1 by CDK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46964", "l": "lactate + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate"}, {"i": "EC:1.3.1.110", "l": "\"Lactate dehydrogenase (NAD(+),ferredoxin)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265858", "l": "Activation of ATR by interaction with RAD9-TopBP1 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62654", "l": "6 CO2 + 7 CoA + H2O + YWA1 => acetyl-CoA + 6 H(+) + 6 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693575", "l": "DNA-PKcs autophosphorylates (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16413", "l": "L-lysyl-[lipoyl-carrier protein] + N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + L-lysyl-[glycine-cleavage complex H protein]"}, {"i": "EC:2.3.1.200", "l": "\"Lipoyl amidotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854738", "l": "CSF3 dimer:CSFR binds CSFR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63906", "l": "H2O + phenguignardate => 2 3-phenylpyruvate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59455", "l": "a long-chain primary fatty alcohol + NADP(+) <=> a long-chain fatty aldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60216", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27667", "l": "(R)-methylmalonyl-CoA + H(+) => CO2 + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14529", "l": "ADP + D-ribose 5-phosphate + H(+) = ADP-D-ribose + phosphate"}, {"i": "EC:2.7.7.35", "l": "\"ADP ribose phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10723", "l": "2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432688", "l": "trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-500366", "l": "LIN28 binds POU5F1 (OCT4) mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805811", "l": "Release of SEPT4 from mitochondria (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30615", "l": "15-cis-phytoene + 2 A = 2 AH2 + all-trans-zeta-carotene"}, {"i": "EC:1.3.99.29", "l": "\"Phytoene desaturase (zeta-carotene-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41009", "l": "6-linalyl-2-O,3-dimethylflaviolin + diphosphate => (2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31228", "l": "di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine => di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52974", "l": "a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin] => a C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044547", "l": "DNA topoisomerase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60622", "l": "choline + N-(hexanoyl)-sphing-4-enine-1,3-cyclic phosphate => N-hexanoyl-sphing-4-enine-1-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388605", "l": "POMC(138-176) binds MC2R (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35378", "l": "(beta-L-Ara4N)2-(Kdo)2-lipid A(in) + ATP + H2O <=> (beta-L-Ara4N)2-(Kdo)2-lipid A(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21408", "l": "H2O + L-phenylalanine + NAD(+) = 3-phenylpyruvate + H(+) + NADH + NH4(+)"}, {"i": "EC:1.4.1.20", "l": "\"Phenylalanine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13620", "l": "H2O + S-methyl-5'-thioadenosine <=> 5-(methylsulfanyl)-D-ribose + adenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26258", "l": "dehydroabietadienol + H(+) + NADPH + O2 => dehydroabietadienal + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29511", "l": "(2E,6E)-farnesyl diphosphate = (+)-valencene + diphosphate"}, {"i": "EC:4.2.3.73", "l": "\"Valencene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66558", "l": "5-dopaminyl-L-glutamyl-[protein] + NH4(+) => dopamine + L-glutaminyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46047", "l": "(3Z)-octenoyl-CoA <=> (2E)-octenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019141", "l": "2-dehydropantolactone reductase (B-specific) activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004381", "l": "fucosylgalactoside 3-alpha-galactosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43043", "l": "hexadecanoyl-CoA + hexadecasphinganine <=> CoA + H(+) + N-hexadecanoylhexadecasphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798743", "l": "Exocytosis of secretory granule membrane proteins (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55251", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672817", "l": "Active MTORC1 binds the ULK1 complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44142", "l": "acetyl-CoA + CO2 + reduced [flavodoxin] => CoA + 2 H(+) + oxidized [flavodoxin] + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40510", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O <=> a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45433", "l": "H2O + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => H(+) + N-(9Z-octadecenoyl) ethanolamine + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785565", "l": "Defective B3GALTL does not transfer glucose to O-fucosyl-proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570493", "l": "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53970", "l": "adenosine 3',5'-bisphosphate + H(+) + holo-[BtrI ACP] => apo-[BtrI ACP] + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0034481", "l": "chondroitin sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26161", "l": "(S)-2,3-epoxysqualene => thalianol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41007", "l": "(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin = 6-linalyl-2-O,3-dimethylflaviolin + diphosphate"}, {"i": "EC:2.5.1.124", "l": "\"6-linalyl-2-O,3-dimethylflaviolin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12213", "l": "9H-fluoren-9-ol + NADP(+) => 9H-fluoren-9-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672973", "l": "MAP2Ks phosphorylate MAPKs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53029", "l": "lithocholate + UDP-alpha-D-glucuronate => H(+) + lithocholoyl-3-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77068", "l": "Activation of GT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38882", "l": "a fatty acid(in) <=> a fatty acid(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65007", "l": "ATP + decanoate + holo-[ACP] <=> AMP + decanoyl-[ACP] + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15355", "l": "all-trans-antheraxanthin + H2O + L-dehydroascorbate => all-trans-violaxanthin + L-ascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37947", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018546", "l": "nitrobenzene nitroreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12634", "l": "benzoate + H(+) + NADH + O2 => (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102467", "l": "scutellarein 7-O-glucuronosyltransferase activity"}, {"i": "RHEA:28318", "l": "scutellarein + UDP-alpha-D-glucuronate = scutellarin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16596", "l": "3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine <=> 3,3',4',5,7-pentahydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56608", "l": "5,10-methylenetetrahydrosulfopterin + glycine + H2O = L-serine + tetrahydrosulfopterin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11413", "l": "6-hydroxymethyl-7,8-dihydropterin + ATP => (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-918229", "l": "Phosphorylation and release of IRF3/IRF7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9010815", "l": "SLITs bind keratan sulfate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10440", "l": "D-glucono-1,5-lactone + H2O = D-gluconate + H(+)"}, {"i": "EC:3.1.1.17", "l": "\"Gluconolactonase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49054", "l": "asperlicin E + H2O + NAD(+) => asperlicin C + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201443", "l": "Type II receptor phosphorylates type I receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32086", "l": "CTP + pseudaminate <=> CMP-pseudaminate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696822", "l": "AKR1B15 reduces EST17b to E1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20778", "l": "myo-inositol + stachyose => alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45970", "l": "9alpha-hydroxy-androst-4-ene-3,17-dione + H2O + NAD(+) => androst-4-ene-3,17-dione + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35097", "l": "acetaldehyde + trimethylamine => choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58881", "l": "4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 => 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29412", "l": "glycolate(in) + H(+)(in) => glycolate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018526", "l": "2-aminobenzoyl-CoA reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21413", "l": "NAD(+) + sn-glycerol 1-phosphate => dihydroxyacetone phosphate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623051", "l": "Defective RHAG does not transport NH4+ from cytosol to extracellular region (rbc) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623999", "l": "BCL gene expression downstream of ESR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23422", "l": "alpha,alpha-trehalose + phosphate => alpha,alpha-trehalose 6-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17425", "l": "CoA + NADP(+) + pyruvate = acetyl-CoA + CO2 + NADPH"}, {"i": "EC:1.2.1.51", "l": "\"Pyruvate dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936941", "l": "Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40960", "l": "2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine => 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295622", "l": "SPRY2 binds CBL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43289", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22744", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.62", "l": "\"mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428287", "l": "IGF2BP3 binds specific RNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53434", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11075", "l": "anthranilate + 3 H(+) + NADPH + O2 <=> catechol + CO2 + NADP(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418874", "l": "Recruitment and activation of N-WASP by Cdc42 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46108", "l": "(2E,6E,10E)-geranylgeraniol + H(+) + 2 NADPH + 2 O2 = (2E,6E,10E)-geranylgeranate + 3 H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33326", "l": "a 1-acyl-sn-glycero-3-phosphate + tetradecanoyl-CoA <=> a 1-acyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694601", "l": "nsp3-4 cleaves itself (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090581", "l": "protein-phosphocysteine-mannosylglycerate-phosphotransferase system transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24334", "l": "H2O + monacolin L carboxylate => 3alpha-hydroxy-3,5-dihydromonacolin L carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16747", "l": "2,3-epoxyphylloquinone + A + H2O => AH2 + O2 + phylloquinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.29", "l": "\"Picornain 2A\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42379", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17183", "l": "a long-chain fatty acid + FMN + 2 H(+) + H2O + hnu => a long-chain fatty aldehyde + FMNH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047307", "l": "diaminobutyrate-pyruvate transaminase activity"}, {"i": "KEGG.REACTION:R02293"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56739", "l": "H2O + O2 + retinal <=> H(+) + H2O2 + retinoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626938", "l": "Beta-catenin binds SOX proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419645", "l": "Dimerization of LIMK1 by Hsp90 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212222", "l": "PRC2 recruits DNA methyltransferases (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49410", "l": "[(1->2)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate => [(1->2)-beta-D-mannosyl](n) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24467", "l": "2-dehydro-3-deoxy-6-phospho-D-galactonate <=> D-glyceraldehyde 3-phosphate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44061", "l": "2-O-sulfo-alpha,alpha-trehalose + hexadecanoyl-CoA => 2-O-sulfo-2'-O-hexadecanoyl-alpha,alpha-trehalose + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202137", "l": "AKT1 binds eNOS complex via HSP90 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59521", "l": "ATP + butanoyl-CoA + hydrogencarbonate => (2S)-ethylmalonyl-CoA + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029268", "l": "Phosphorylation and activation of PLCG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380294", "l": "Loss of C-Nap-1 from centrosomes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18874", "l": "3-chloro-D-alanine + H2O => chloride + H(+) + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16190", "l": "3-(4-hydroxyphenyl)pyruvate + O2 => CO2 + homogentisate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939203", "l": "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55597", "l": "globoside NOR1 + UDP-N-acetyl-alpha-D-galactosamine => globoside NORint + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45912", "l": "a (2E,4E)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)"}, {"i": "RHEA:61892", "l": "a (2E,4Z)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)"}, {"i": "EC:1.3.1.124", "l": "\"2,4-dienoyl-CoA reductase ((3E)-enoyl-CoA-producing)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061579", "l": "N-acyl homoserine lactone synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26349", "l": "beta-L-galactose 1-phosphate + H2O = L-galactose + phosphate"}, {"i": "EC:3.1.3.93", "l": "\"L-galactose 1-phosphate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004363", "l": "glutathione synthase activity"}, {"i": "REACT:R-HSA-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60162", "l": "ADP + H(+) + phosphate + vincristine(out) => ATP + H2O + vincristine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54778", "l": "[LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+) => 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39563", "l": "(2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H(+) + NADPH = (23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41155", "l": "1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-8E-octadecenoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34710", "l": "AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46212", "l": "H2O + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine = 4-amino-5-aminomethyl-2-methylpyrimidine + formate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16897", "l": "a 3beta-hydroxysteroid + a triacylglycerol = a 3beta-hydroxysteroid ester + a diacylglycerol"}, {"i": "EC:2.3.1.77", "l": "\"Triacylglycerol--sterol O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696960", "l": "USP49 deubiquitinates H2B (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800793", "l": "PIDD1 translocates to the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68637", "l": "CDC6 protein is synthesized under the control of E2F transcription factors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53243", "l": "cholesta-5,7-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35754", "l": "ATP + kanosamine <=> ADP + D-kanosamine 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19941", "l": "norcoclaurine + S-adenosyl-L-methionine = coclaurine + H(+) + S-adenosyl-L-homocysteine"}, {"i": "RHEA:31907", "l": "(S)-norcoclaurine + S-adenosyl-L-methionine = (S)-coclaurine + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.128", "l": "\"(RS)-norcoclaurine 6-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35009", "l": "D-fucose(out) => D-fucose(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55711", "l": "[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) <=> [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874718", "l": "TTPA binds alpha-TOH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159194", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984023", "l": "p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418456", "l": "cGMP is degraded by PDEs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16699", "l": "AH2 + kynurenate => A + H2O + quinaldate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015126", "l": "canalicular bile acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047733", "l": "CDP-glucose 4,6-dehydratase activity"}, {"i": "RHEA:17153", "l": "CDP-D-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H2O"}, {"i": "EC:4.2.1.45", "l": "\"CDP-glucose 4,6-dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788668", "l": "TRMT13 2'-O-methylates adenosine-4 in tRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446364", "l": "Migfilin interacts with VASP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867613", "l": "PICALM binds R-SNAREs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050644", "l": "cis-p-coumarate glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60739", "l": "(2E,6E)-farnesal + H2O + NADP(+) <=> (2E,6E)-farnesoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39852", "l": "2 a 1-acyl-sn-glycerol => a 1,2-diacyl-sn-glycerol + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11182", "l": "AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn) => ATP + L-asparagine + tRNA(Asn)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45835", "l": "(3R)-3-hydroxydecanoyl-CoA + NAD(+) <=> 3-oxodecanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66260", "l": "CoA + IC-asc-C7-AMP = AMP + H(+) + IC-asc-C7-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954207", "l": "ERBB4s80:ESR1 binds CXCL12 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61397", "l": "ATP + N(6)-(D-erythrulosyl)-L-lysyl-[protein] => ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10654", "l": "a long-chain fatty acid + 2 H(+) + NADH => a long-chain fatty aldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25959", "l": "2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) <=> 3-dehydroquinate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54698", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + diphosphate => 4-hydroxybenzoate + ATP + holo-[4-hydroxyphenylalkanoate synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51239", "l": "GTP + L-glutamate + oxidized coenzyme F420-(gamma-Glu)(n) <=> GDP + H(+) + oxidized coenzyme F420-(gamma-Glu)(n+1) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4411402", "l": "Activation of NLK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15635", "l": "2-hydroxy-5-carboxymethylmuconate semialdehyde + H(+) => 3,4-dihydroxyphenylacetate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21744", "l": "S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + H(+) + S-methyl-5'-thioadenosine"}, {"i": "EC:4.4.1.14", "l": "\"1-aminocyclopropane-1-carboxylate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.4.7", "l": "\"Enzyme-thiol transhydrogenase (glutathione-disulfide)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35609", "l": "diacetyl + H(+) + NADPH => acetoin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17304", "l": "ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] <=> ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866304", "l": "pre-VLDL binds lipids to form VLDL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37056", "l": "3-(4-hydroxyphenyl)pyruvate + dimethylallyl diphosphate => 3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49999", "l": "cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> (25R)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60634", "l": "all-trans-4-oxoretinal + H(+) + NADH => all-trans-4-oxoretinol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15099", "l": "(6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate => 5-formimidoyltetrahydrofolate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10853", "l": "dimethylallyl diphosphate + leachianone G => diphosphate + sophoraflavanone G"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59753", "l": "L-lysyl-[protein] + tetradecanoyl-CoA => CoA + H(+) + N(6)-tetradecanoyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36852", "l": "(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001602", "l": "pancreatic polypeptide receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35588", "l": "FMN + H2O => phosphate + riboflavin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35613", "l": "2 H(+) + menadione + 2 superoxide => menadiol + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57231", "l": "GDP + glyoxal <=> N(2)-(1-hydroxy-2-oxoethyl)-GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17192", "l": "ATP + L-phenylalanine <=> diphosphate + H(+) + N-adenylyl-L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004632", "l": "phosphopantothenate--cysteine ligase activity"}, {"i": "RHEA:19397", "l": "(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine"}, {"i": "EC:6.3.2.5", "l": "\"Phosphopantothenate--cysteine ligase (CTP)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229283", "l": "LCNs bind lipids (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42415", "l": "(2R)-2,3-bisphosphoglycerate + ATP + H(+) <=> ADP + cyclic (2R)-2,3-bisphosphoglycerate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62404", "l": "(R)-2-hydroxyhexadecanoate + O2 = CO2 + H2O + pentadecanoate"}, {"i": "EC:1.14.18.12", "l": "\"2-hydroxy fatty acid dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15410", "l": "1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine => 1-O-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58564", "l": "15alpha-stemmadenine + NADP(+) = 15alpha-stemmadenine intermediate II + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140631", "l": "aldehyde dehydrogenase (NAD+) inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44285", "l": "2 H(+) + 2 malonyl-CoA + octanoyl-CoA => 4-hydroxy-6-heptylpyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654163", "l": "Activated FGFR4 binds PLCG1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451033", "l": "(S)-Malate <=> Fumarate + H2O (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975188", "l": "TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65042", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + a tri-(9Z,12Z-octadecadienoyl)-monolysocardiolipin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209910", "l": "Iodide is taken up by thyroid epithelial cells (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57875", "l": "(E)-2,4-dihydroxycinnamoyl-CoA <=> CoA + umbelliferone"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070530", "l": "K63-linked polyubiquitin modification-dependent protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390597", "l": "Release Of ADP From Myosin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809521", "l": "BPIF binds bacteria (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606624", "l": "Active FLT3:GRB2 binds GAB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374723", "l": "Nociceptin receptor binds to nociceptin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11845", "l": "acetyl-CoA + formate => CoA + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40688", "l": "1-hexadecanoylglycerone 3-phosphate + tetradecan-1-ol => 1-O-tetradecylglycerone 3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14087", "l": "5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate => (2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626848", "l": "S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45321", "l": "H2O + N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine => H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4647594", "l": "SAHF formation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16353", "l": "2-oxoglutarate + taurine = L-glutamate + sulfoacetaldehyde"}, {"i": "EC:2.6.1.55", "l": "\"Taurine--2-oxoglutarate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170978", "l": "p-FRS2:CRKL binds C3G (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55723", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1638845", "l": "CERK phosphorylates CERA to form C1P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061473", "l": "murein tripeptide carboxypeptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390846", "l": "D2D3,4 bind to DA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607004", "l": "Soluble PROCR binds PRTN3:CD177 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26200", "l": "H2O + melamine <=> ammeline + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660666", "l": "CBP and p300 binds NF-kB complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605768", "l": "Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28768", "l": "ethylnitronate + O2 => acetaldehyde + chemical entity + H(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32470", "l": "2 S-adenosyl-L-methionine + sarcosine <=> glycine betaine + 2 H(+) + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6797090", "l": "CCNK binds CDK12 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623018", "l": "FOXO1 binds AGRP gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983156", "l": "Polyubiquitination of substrate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58414", "l": "H2O + L-homocysteine + oxidized 2[4Fe-4S]-[ferredoxin] => 3 H(+) + hydrogen sulfide + L-aspartate 4-semialdehyde + reduced 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.7", "l": "\"Plasmin\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030373", "l": "high molecular weight B cell growth factor receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54110", "l": "diphosphate + guaia-4,6-diene => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5223313", "l": "ABCD4:LMBRD1 transports Cbl from lysosomal lumen to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015284", "l": "fructose uniporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102086", "l": "N-vanillate-L-glutamate synthetase activity"}, {"i": "MetaCyc:RXN-10885"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64721", "l": "H(+)(out) + pyruvate(out) => H(+)(in) + pyruvate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688397", "l": "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29395", "l": "H2O + UTP = diphosphate + H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-178178", "l": "PP1 dephosphorylates TGFBR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37506", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909724", "l": "Recruitment of IFNAR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140682", "l": "histone H3-di/monomethyl-lysine-4 FAD-dependent demethylase activity"}, {"i": "RHEA:60244", "l": "2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] = 2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3]"}, {"i": "EC:1.14.99.66", "l": "\"[Histone-H3]-N(6),N(6)-dimethyl-L-lysine(4) FAD-dependent demethylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2247510", "l": "MARCO:ligand is endocytosed (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694527", "l": "Loss of SAR1B GTPase (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60126", "l": "diphosphate + sodorifen => pre-sodorifen diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54021", "l": "L-lysyl-[protein] + propanoyl-CoA => CoA + H(+) + N(6)-propanoyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39794", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0005363", "l": "maltose transmembrane transporter activity"}, {"i": "RHEA:33171", "l": "D-maltose(in) = D-maltose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22111", "l": "L-threonine <=> 2-oxobutanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61376", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58735", "l": "5-methyl-CTP + H2O <=> 5-methyl-CMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14543", "l": "cholate + CoA + H(+) => choloyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53741", "l": "[Rab1 protein]-O(4)-(5'-adenylyl)-L-tyrosine + H2O => [Rab1 protein]-L-tyrosine + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43365", "l": "L-erythro-N-acylsphing-4-enine + UDP-alpha-D-glucose => beta-D-glucosyl-L-erythro-N-acylsphing-4-enine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0016423", "l": "tRNA (guanine) methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034528", "l": "2-carboxy-2-hydroxy-8-carboxychromene isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53595", "l": "1-tetradecanoyl-sn-glycerol 3-phosphate + H2O <=> 1-tetradecanoyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74986", "l": "Elongation of pre-rRNA transcript (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357845", "l": "RIPK1 is deubiquitinated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22918", "l": "4-acetoxyphenol + H2O + NADP(+) => 4'-hydroxyacetophenone + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-990489", "l": "Kinesin-13 is a dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62193", "l": "O2 + peregrinol + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901707", "l": "leptomycin B binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15043", "l": "inulobiose => bis-D-fructose 2',1:2,1'-dianhydride + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354173", "l": "Activation of Rap1 by cytosolic GEFs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54664", "l": "(3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene = pre-alpha-onocerin"}, {"i": "EC:5.4.99.65", "l": "\"Pre-alpha-onocerin synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034858", "l": "2-hydroxybenzothiazole monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64087", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) <=> 2,3,6,8,9-pentahydroxy-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracen-1-one + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692880", "l": "HRH3 binds Hist (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63979", "l": "A + dihydropyriculariol <=> AH2 + pyriculariol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29026", "l": "H(+)(in) + L-fucose(in) <=> H(+)(out) + L-fucose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683760", "l": "GalNAc is transferred onto 3a (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626938", "l": "Beta-catenin binds SOX proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814374", "l": "Kazrin binds periplakin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30556", "l": "GTP + L-glutamate + oxidized coenzyme F420-0 => GDP + H(+) + oxidized coenzyme F420-1 + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60354", "l": "CO + H(+) + N-octanoylanthranilate => 2-heptyl-3-hydroxy-4(1H)-quinolone + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30475", "l": "H2O + oroxylin A 7-O-beta-D-glucuronate = D-glucuronate + H(+) + oroxylin A"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080015", "l": "sabinene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60835", "l": "a 5'-end triphospho-guanosine in mRNA + H2O <=> a 5'-end diphospho-guanosine in mRNA + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47548", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oate = 3-oxochola-4,6-dien-24-oate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16718", "l": "deoxycholate + FAD + H(+) + H2O => cholate + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34010", "l": "cholesta-5,7,24-trien-3beta-ol + S-adenosyl-L-methionine <=> ergosta-5,7,24(28)-trien-3beta-ol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2288097", "l": "Condensin II complex binds H4K20me1-containing nucleosomes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6805640", "l": "AKT phosphorylates KAT6A (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44010", "l": "2-methyl fatty acid + 2 H(+) + NADH => 2-methyl-branched fatty aldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13120", "l": "O-acetyl-L-serine + pyrazole <=> 3-(pyrazol-1-yl)-L-alanine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18286", "l": "an N-acyl-D-aspartate + H2O => a carboxylate + D-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45394", "l": "(9Z)-octadecenoate + H(+) + N-eicosanoyl-sn-glycero-3-phosphoethanolamine => H2O + N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50509", "l": "acetyl-CoA + N-terminal L-valyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23802", "l": "2-oxobutanoate + methanethiol + NH4(+) => H2O + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26468", "l": "a menaquinone + H(+) + S-adenosyl-L-homocysteine => a 2-demethylmenaquinone + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66679", "l": "(2E,6E)-farnesyl diphosphate + 5,7-dihydroxy-4-methylphthalide <=> 4-farnesyl-3,5-dihydroxy-6-methylphthalide + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9669893", "l": "KIT binds type I TKIs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15367", "l": "3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + H(+) + UDP => 3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + UDP-alpha-D-xylose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54492", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine = 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051118", "l": "glucan endo-1,3-alpha-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.21"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61447", "l": "a tetracycline + H(+) + NADPH + O2 <=> an 11a-hydroxytetracycline + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12618", "l": "ATP + N-acetyl-alpha-D-galactosamine => ADP + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380949", "l": "AMPK is dephosphorylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17870", "l": "5,6,7,8-tetrahydropteridine + NAD(+) => 6,7-dihydropteridine + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20595", "l": "acetate + D-glucosamine => H2O + N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3828025", "l": "DCN (decorin) degradation by MMP14 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102719", "l": "S-adenosyl-L-methionine:eugenol-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-6741"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30302", "l": "2-oxoglutarate + a methylated nucleobase within DNA + O2 <=> a nucleobase within DNA + CO2 + formaldehyde + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425861", "l": "Activation of Protein Kinase C novel isoforms (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877902", "l": "Activated AR binds RUNX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102828", "l": "stachyose galactinol:verbascose galactosyltransferase activity"}, {"i": "MetaCyc:RXN-8284"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29255", "l": "Ca(2+)(in) + Na(+)(out) = Ca(2+)(out) + Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53893", "l": "an S-prenyl-L-cysteine + H2O + O2 => a prenal + H2O2 + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24342", "l": "(R)-acetoin + H(+) + NADH => (R,R)-butane-2,3-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57789", "l": "1,3-dinitrobenzene + NADH + O2 => 4-nitrocatechol + H(+) + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18130", "l": "2-oxoaldehyde + H2O + NADP(+) => a 2-oxocarboxylate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33699", "l": "2 [Fe(II)-cytochrome b5] + C20 sphinganine + 2 H(+) + O2 = (4R)-hydroxyeicosasphinganine + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617660", "l": "ROS oxidize FOXO4 cysteine residues (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614605", "l": "Persulfide sulfur is dioxygenated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27294", "l": "D-glucose 6-phosphate + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) = 6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-Glu)(n)"}, {"i": "EC:1.1.98.2", "l": "\"Glucose-6-phosphate dehydrogenase (coenzyme-F420)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54398", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783670", "l": "CRLF1 binds CLCF1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52722", "l": "5-methyl-2-thiouridine(54) in tRNA + [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + AMP + diphosphate + 2 H(+) => 5-methyluridine(54) in tRNA + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40403", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866277", "l": "AP-2 directly binds some endocytic cargo (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070915", "l": "lysophosphatidic acid receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8943279", "l": "GGT dimers hydrolyse GSH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199587", "l": "KIR2DS1 interacting with HLA-C group 2 (Cw4) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26446", "l": "3-oxopropanoate + CoA + NADP(+) = H(+) + malonyl-CoA + NADPH"}, {"i": "EC:1.2.1.75", "l": "\"Malonyl CoA reductase (malonate semialdehyde-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9608288", "l": "Defective MUTYH mutants do not bind adenine mispaired with 8-oxoguanine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60017", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + sesquisabinene B"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015314", "l": "aminotriazole:proton antiporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050254", "l": "rhodopsin kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9727349", "l": "XDH dehydrogenates xanthine to form urate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35600", "l": "NADP(+) + propane-1,3-diol => 3-hydroxypropanal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30102", "l": "1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-8 + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46451", "l": "2 L-tyrosyl-tRNA(Tyr) <=> cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849435", "l": "PTPN1 dephosphorylates PTK6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-447130", "l": "Interleukin-23 binds interleukin-23 receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48436", "l": "H2O + pentanoate ester = an aliphatic alcohol + H(+) + pentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964513", "l": "E2F1 gene transcription is inhibited by the DREAM complex, RBL1 and RBL2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32109", "l": "H(+) + pterostilbene + S-adenosyl-L-homocysteine => 3-methoxy-4',5-dihydroxy-trans-stilbene + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54409", "l": "1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811472", "l": "IER3 recruits MAPKs to PP2A-B56-beta,gamma (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981355", "l": "RASA1 binds RAS:GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29227", "l": "H(+)(in) + indole(in) = H(+)(out) + indole(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.9", "l": "\"Xaa-Pro aminopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60655", "l": "an N-(acyl)-sphingosylphosphocholine <=> an N-(acyl)-sphingosyl-1,3-cyclic phosphate + choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141046", "l": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30459", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol = (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + acetone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36828", "l": "dioscin + 3 H2O => D-glucose + diosgenin + 2 L-rhamnopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40707", "l": "(9Z,12Z,15Z)-octadecatrien-1-ol + 1-hexadecanoylglycerone 3-phosphate = 1-O-(9Z,12Z,15Z)-octadecatrienylglycerone 3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47886", "l": "CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57544", "l": "(S)-beta-macrocarpene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + zealexin A1"}, {"i": "EC:1.14.14.160", "l": "\"Zealexin A1 synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371435", "l": "Constitutive phosphorylation by GSK3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1462041", "l": "HNP1-4 are released into phagocytic vacuoles (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10227", "l": "ATP + pyridoxal <=> ADP + H(+) + pyridoxal 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37489", "l": "1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794354", "l": "NMDA receptor complex:DLG2,DLG3,DLG4:SPAR binds PDLIM5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624798", "l": "LBR binds KPNB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204434", "l": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35652", "l": "(4R)-hydroxysphinganine + a fatty acyl-CoA => an N-acyl-(4R)-4-hydroxysphinganine + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35871", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16494", "l": "glycerol 1,2-cyclic phosphate + H2O => glycerol 1-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804188", "l": "PRDM1 represses TP53 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35237", "l": "H(+)(in) + tetracycline(out) => H(+)(out) + tetracycline(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24192", "l": "(2R,4S)-2,4-diaminopentanoate + H2O + NADP(+) = (2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53998", "l": "(14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57182", "l": "N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] => L-lysyl-[protein] + methylglyoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1222376", "l": "NOX2 generates superoxide from oxygen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23688", "l": "adenine + H(+) + H2O = hypoxanthine + NH4(+)"}, {"i": "EC:3.5.4.2", "l": "\"Adenine deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10039", "l": "4-hydroxy-3-methoxy-benzenemethanol + O2 <=> H2O2 + vanillin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45380", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + (5Z,8Z,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854462", "l": "VLDLR binds VLDL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51457", "l": "H2O + N-(9Z-octadecenoyl)-L-isoleucine => (9Z)-octadecenoate + L-isoleucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21783", "l": "A + cyclohexanone <=> AH2 + cyclohex-2-enone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48260", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 = CMP + ganglioside GD1a + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22923", "l": "L-glutamine + scyllo-inosose <=> 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63889", "l": "hexadecanoyl-CoA + sphinga-4E,14Z-dienine => CoA + H(+) + N-hexadecanoyl-sphinga-4E,14Z-dienine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58139", "l": "acetate + ATP + H(+) <=> acetyl-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44127", "l": "hexadecanoyl-CoA + tetradecan-1-ol <=> CoA + tetradecanyl hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5339535", "l": "GLTPD1 transports C1P from plasma membrane to Golgi membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607721", "l": "Activation of NIK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2995334", "l": "COX15 transforms heme O to heme A (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12045", "l": "a triacylglycerol + H2O => a diacylglycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5444511", "l": "Formation of MSH2:MSH3 Complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849428", "l": "PTPN1 binds PTK6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52489", "l": "O2 + prostaglandin E2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy prostaglandin E2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53073", "l": "2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate => 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60557", "l": "uridine(35) in tRNA(Tyr) => pseudouridine(35) in tRNA(Tyr)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45780", "l": "(9Z)-octadecenoyl-CoA + di-(9Z)-octadecenoylglycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689630", "l": "BAP1 binds BAP1-interacting complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805811", "l": "Release of SEPT4 from mitochondria (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166538", "l": "The bound receptor dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198983", "l": "NKG2D homodimer interacting with ligands (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19708", "l": "CoA + hexadecanal + NAD(+) <=> H(+) + hexadecanoyl-CoA + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9615249", "l": "ARBs bind AGRT1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16269", "l": "aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP(+) = 4-(dimethylamino)azobenzene + 2 H(+) + 2 NADPH"}, {"i": "EC:1.7.1.6", "l": "\"Azobenzene reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022065", "l": "DSPGs are secreted (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5444523", "l": "Formation of MSH1:PMS2 Complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9035227", "l": "TXN2 binds CysS248-MPST (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-448673", "l": "Formation of caspase-1 p10/p20 dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159771", "l": "Furin cleaves pro-protein C to protein C (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420131", "l": "The PACAP receptor binds PACAP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982645", "l": "GRKs bind ADRB2:Catecholamine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14230", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin] => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40921", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.10", "l": "\"Streptopain\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-178208", "l": "SMAD7 binds to SMURF2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28327", "l": "H2O + wogonin 7-O-beta-D-glucuronate => D-glucuronate + H(+) + wogonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203611", "l": "N-myristoylation of eNOS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878654", "l": "ACP6 hydrolyses MYS-LPA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29931", "l": "alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP = ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60334", "l": "H(+) + N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19373", "l": "H2O + L-saccharopine + NADP(+) = 2-oxoglutarate + H(+) + L-lysine + NADPH"}, {"i": "EC:1.5.1.8", "l": "\"Saccharopine dehydrogenase (NADP(+), L-lysine-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29267", "l": "L-valine(in) + Na(+)(in) = L-valine(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672162", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689000", "l": "AADAC deacetylates PHEN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "81.20444558259193", "identifiers": [{"i": "GO:0017046", "l": "peptide hormone binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668395", "l": "CHMP7 binds CC2D1B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.33"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24325", "l": "6-oxocineole + H(+) + NADPH + O2 => 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005171", "l": "hepatocyte growth factor receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12597", "l": "acetyl-CoA + phosphinothricin = CoA + H(+) + N-acetylphosphinothricin"}, {"i": "EC:2.3.1.183", "l": "\"Phosphinothricin acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75080", "l": "Formation of AT-AC A complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40970", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5688834", "l": "ATXN3 binds VCP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1605736", "l": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48223", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tricosanoyl-CoA <=> (2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47508", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADH = isolithocholate + NAD(+)"}, {"i": "EC:1.1.1.391", "l": "\"3-beta-hydroxycholanate 3-dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22037", "l": "[phosphate](n) + D-glucose => [phosphate](n-1) + D-glucose 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981814", "l": "GalNAc alpha-2,6-sialyltransferase II can add a sialic acid to the T antigen at the alpha 6 position (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22064", "l": "5alpha-ergosta-7,22-diene-3beta,5-diol = ergosterol + H2O"}, {"i": "EC:4.2.1.62", "l": "\"5-alpha-hydroxysteroid dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49228", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + bacteriochlorophyllide a + H(+) = diphosphate + geranylgeranyl-bacteriochlorophyllide a"}, {"i": "EC:2.5.1.133", "l": "\"Bacteriochlorophyll a synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050091", "l": "melilotate 3-monooxygenase activity"}, {"i": "RHEA:17669", "l": "3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)"}, {"i": "EC:1.14.13.4", "l": "\"Melilotate 3-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66758", "l": "ADP + domoate(out) + H(+) + phosphate => ATP + domoate(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9659820", "l": "RB1 translocates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53852", "l": "glycocholate + NAD(+) = 7-oxo-glycodeoxycholate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48898", "l": "3,8-divinyl protochlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => 2 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide a"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66151", "l": "2-phenylethylamine + acetyl-CoA <=> CoA + H(+) + N-(2-phenylethyl)acetamide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005540", "l": "hyaluronic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70482", "l": "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57096", "l": "AH2 + S-methyl-1-thio-D-xylulose 5-phosphate = 1-deoxy-D-xylulose 5-phosphate + A + methanethiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53792", "l": "benzylthiol + O2 = benzothialdehyde + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373087", "l": "Receptor CCR6 binds CCL20 ligand (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15864", "l": "3-ADP-2-phosphoglycerate + H2O <=> 3-ADP-glycerate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047395", "l": "glycerophosphoinositol glycerophosphodiesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.53"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389348", "l": "Activation of Rac1 by pVav1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20370", "l": "betaine aldehyde + H2O + O2 => glycine betaine + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21612", "l": "D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15037", "l": "putrescine + S-adenosyl-L-methionine = H(+) + N-methylputrescine + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.53", "l": "\"Putrescine N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614605", "l": "Persulfide sulfur is dioxygenated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62638", "l": "(R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O => (R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018765", "l": "2-hydroxy-6-oxohepta-2,4-dienoate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44224", "l": "16-hydroxyhexadecanoate + ATP + CoA = 16-hydroxyhexadecanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186780", "l": "PI3-kinase binds to the active receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034812", "l": "9,10-dihydroxybenzo(a)pyrene dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194808", "l": "botF LC cleaves target cell VAMP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31806", "l": "H2O + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose <=> 2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035757", "l": "chemokine (C-C motif) ligand 19 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50972", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18896", "l": "a flavonol 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672304", "l": "IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15308", "l": "betaine aldehyde + H2O + NAD(+) <=> glycine betaine + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004121", "l": "cystathionine beta-lyase activity"}, {"i": "RHEA:13965", "l": "H2O + L,L-cystathionine = L-homocysteine + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8953339", "l": "DNPH1 hydrolyses dGMP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015254", "l": "glycerol channel activity"}, {"i": "REACT:R-HSA-507871", "l": "Aquaporins passively transport glycerol out of cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22366", "l": "3-dehydroquinate + H(+) + NADH => L-quinate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35707", "l": "(2S)-versicolorone + H(+) + NADPH + O2 = (3S)-versiconol acetate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57945", "l": "H(+) + H2O2 + harderoheme III => CO2 + 2 H2O + heme b"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61244", "l": "H2O + L-tryptophan + O2 = H2O2 + indole-3-pyruvate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33806", "l": "H2O + L-histidinal + NAD(+) <=> 2 H(+) + L-histidine + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420121", "l": "SFKs phosphorylate PLCG1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102534", "l": "apigenin-7,4'-dimethyl ether 6-hydroxylase activity"}, {"i": "MetaCyc:RXN-14751"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28280", "l": "H(+) + L-alanine + sulfite => 3-sulfino-L-alanine + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080099", "l": "L-methionine:2-oxoglutarate aminotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30479", "l": "L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853801", "l": "PSPN binds RET:GFRA4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28567", "l": "3 2,3-dihydroxybenzoyl-5'-AMP + 3 L-seryl-5'-AMP => 6 AMP + enterobactin + 7 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46621", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol => (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654167", "l": "Activated FGFR1 binds PLCG1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28326", "l": "H2O + wogonin 7-O-beta-D-glucuronate = D-glucuronate + H(+) + wogonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69127", "l": "Formation of the Flap Intermediate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.57", "l": "\"Isopullulanase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31062", "l": "H2O + imidazole-4-acetaldehyde + NAD(+) <=> 2 H(+) + imidazole-4-acetate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141367", "l": "Myristoylation of tBID by NMT1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047271", "l": "glycosaminoglycan galactosyltransferase activity"}, {"i": "MetaCyc:2.4.1.74-RXN"}, {"i": "EC:2.4.1.74", "l": "\"Glycosaminoglycan galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198756", "l": "ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193068", "l": "CYP17A1 17-hydroxylates PREG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12028", "l": "H2O + L-5-carboxymethylhydantoin = H(+) + N-carbamoyl-L-aspartate"}, {"i": "EC:3.5.2.4", "l": "\"Carboxymethylhydantoinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38299", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63588", "l": "prunetin + UDP-alpha-D-glucuronate = prunetin-4'-O-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59923", "l": "(2E)-octenal + H2O + NAD(+) <=> (2E)-octenoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507873", "l": "Aquaporins passively transport urea out of cells (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33605", "l": "H2O + N-(2-hydroxyhexacosanoyl)-sphinganine + NADP(+) => H(+) + N-hexacosanoylsphinganine + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-593685", "l": "Netrin-4 binds DCC/UNC5A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167089", "l": "Recognition and binding of the HIV-1 mRNA cap by the cap-binding complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170674", "l": "Dissociation of the Gi alpha:G olf complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3076905", "l": "Extracellular BTD hydrolyses BCTN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017025", "l": "TBP-class protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.105", "l": "\"Monocyclic monoterpene ketone monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73800", "l": "SAICAR => AICAR + Fumarate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8932327", "l": "NFE2L2 binds KEAP1:CUL3:RBX1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33412", "l": "(S)-malyl N-acetyl-alpha-D-glucosaminide + H2O => (S)-malyl alpha-D-glucosaminide + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.35"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050278", "l": "sedoheptulose-bisphosphatase activity"}, {"i": "RHEA:17461", "l": "H2O + sedoheptulose 1,7-bisphosphate = D-sedoheptulose 7-phosphate + phosphate"}, {"i": "EC:3.1.3.37", "l": "\"Sedoheptulose-bisphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210271", "l": "Interaction of DAP12 and MDL-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33581", "l": "H(+) + NADH + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate => NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58527", "l": "15alpha-stemmadenine intermediate I + H2O + NADPH <=> (16S)-deshydroxymethyl-stemmadenine + formate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389961", "l": "ADP is exchanged for ATP in the (ADP:CCT/TriC):tubulin complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209196", "l": "Phosphorylation of CI by PKA-C1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20068", "l": "2'-deoxymugineate + 2-oxoglutarate + O2 <=> 3-epihydroxy-2'-deoxymugineate + CO2 + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047953", "l": "glycerol 2-dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160874", "l": "HYAL1 hydrolyses (HA)50 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433374", "l": "Processing of SCF isoform 1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102340", "l": "3-oxo-behenoyl-CoA reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428533", "l": "Inactivation of CDC42 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0016680", "l": "oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor"}, {"i": "EC:1.10.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31825", "l": "cubebol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57557", "l": "(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + zealexin A1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53528", "l": "1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-(9Z-octadecenoyl)-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24683", "l": "5,10-methylenetetrahydromethanopterin + NADP(+) => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381109", "l": "IRE1 binds IRE1 forming dimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40565", "l": "dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 H2O + NADP(+) => dTDP-N-hydroxy-beta-L-evernosamine + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44568", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + H(+) = 2-all-trans-hexaprenylphenol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.63"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692135", "l": "SOX9, NR5A1 (SF1), and GATA4 bind the AMH gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798372", "l": "ATM phosphorylates DYRK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46227", "l": "(E)-feruloyl-CoA + H2O <=> (E)-ferulate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42137", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphinganine => a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022399", "l": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20740", "l": "H2O + trans-2,3-epoxysuccinate = (2R,3S)-tartrate"}, {"i": "EC:3.3.2.4", "l": "\"Trans-epoxysuccinate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0039556", "l": "MDA-5 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.13", "l": "\"Retroviral ribonuclease H\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50117", "l": "eicosanoyl-CoA + taurine => CoA + H(+) + N-eicosanoyl-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426032", "l": "DAG is metabolized by DAGL to 2-AG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432712", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42787", "l": "adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374669", "l": "L1 binds NRP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13338", "l": "D-glucurono-6,2-lactone + H2O => D-glucuronate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51707", "l": "S-adenosyl-L-methionine + xanthohumol <=> 4-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35676", "l": "H(+) + L-serine + tetradecanoyl-CoA => 3-oxohexadecasphinganine + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48330", "l": "GDP + H(+) + III(4)-a-Fuc-Lc4Cer(d18:1(4E)) => a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-500708", "l": "GRIK3 homomer binds glutamate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482892", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102817", "l": "caffeoyl-CoA:3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) 3'-O-hydroxycinnamoyltransferase activity"}, {"i": "MetaCyc:RXN-8235"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36959", "l": "D-ribono-1,4-lactone + H(+) + NADH = D-ribose + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49989", "l": "acetone + H(+) + NADPH + O2 => H2O + methyl acetate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661517", "l": "LUBAC comlex binds OTULIN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047925", "l": "geranoyl-CoA carboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10657", "l": "guanidinoacetate + S-adenosyl-L-methionine => creatine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28544", "l": "CoA + fluoroacetate + H(+) => fluoroacetyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451895", "l": "IL2RG binds JAK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33943", "l": "H(+) + 2 L-arginine + 3 NADH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NAD(+) + 2 nitric oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58443", "l": "N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25810", "l": "3-aminopropanal + H2O2 + putrescine => H2O + O2 + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43074", "l": "erythrodiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213208", "l": "Type X collagen associates with collagen type II fibrils (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31504", "l": "beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphoenolpyruvate => 4,6-Me(COOH)C-beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:1901567", "l": "fatty acid derivative binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39251", "l": "(2E,11Z)-eicosadienoyl-CoA + H(+) + NADPH = (11Z)-eicosenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50055", "l": "ATP + H2O + taurocholate(in) <=> ADP + H(+) + phosphate + taurocholate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31670", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-glucose <=> dTDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63570", "l": "beta-casomorphin-6 + L-isoleucine => beta-casomorphin-7 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55937", "l": "all-trans-4-hydroxyretinol + NAD(+) => all-trans-4-hydroxyretinal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36463", "l": "glycyl-L-glutamate + H2O = glycine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65944", "l": "AH2 + CTP + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72671", "l": "eIF5B:GTP is hydrolyzed and released (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60049", "l": "a 3beta-hydroxy-4,4-dimethylsteroid + 2 H(+) + 3 NADH + 3 O2 => a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 4 H2O + 3 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38313", "l": "daunorubicin + H(+) + S-adenosyl-L-homocysteine => carminomycin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1358790", "l": "RNF41 ubiquitinates ERBB3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4093342", "l": "SDC2 multimerises (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13762", "l": "L-methionine + S-adenosyl-L-methionine => S-adenosyl-L-homocysteine + S-methyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39564", "l": "(2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H(+) + NADPH => (23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32173", "l": "2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+) => H(+) + NADPH + O2 + phenylacetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13803", "l": "4 H(+) + 3 NADPH + sulfite => 3 H2O + hydrogen sulfide + 3 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47519", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH <=> isochenodeoxycholate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2328037", "l": "Fibrillin-1 binds integrins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061662", "l": "ISG15 ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24678", "l": "5,6,7,8-tetrahydromethanopterin + formaldehyde = 5,10-methylenetetrahydromethanopterin + H2O"}, {"i": "EC:4.2.1.147", "l": "\"5,6,7,8-tetrahydromethanopterin hydro-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17148", "l": "2'-hydroxy-2,3-dihydrodaidzein + NADP(+) <=> 2'-hydroxydaidzein + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33447", "l": "4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13736", "l": "an n-alkanal + NAD(+) <=> an alk-2-enal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47827", "l": "H(+) + malonyl-[ACP] + octadecanoyl-[ACP] <=> 3-oxoeicosanoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31272", "l": "1-hydroxy-2-naphthoate + 2 H(+) + NADH + O2 => CO2 + H2O + NAD(+) + naphthalene-1,2-diol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102750", "l": "tetrahydrogeranylgeranyl-chlorophyll a reductase activity"}, {"i": "MetaCyc:RXN-7666"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83788", "l": "Binding of TFIIIC to Type 2 promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59737", "l": "L-cysteinyl-[protein] + tetradecanoyl-CoA => CoA + S-tetradecanoyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44978", "l": "CoA + O-propanoyl-(R)-carnitine => (R)-carnitine + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30112", "l": "Fe(III)-enterobactin + H(+) + 3 H2O => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50910", "l": "A + a 3-demethylubiquinol + H2O => a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902379", "l": "chemoattractant activity involved in axon guidance"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218804", "l": "p38 MAPK activation by VEGFR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23936", "l": "D-gluconate + NADP(+) = 5-dehydro-D-gluconate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662986", "l": "MT2A binds copper (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63286", "l": "8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25716", "l": "N-hydroxy-L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19184", "l": "a very-long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850534", "l": "PDCL promotes G-protein beta 5 folding (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-947514", "l": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32172", "l": "H(+) + NADPH + O2 + phenylacetyl-CoA => 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68914", "l": "DNA polymerase alpha:primase binds at the origin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45258", "l": "hexadecanoate(in) => hexadecanoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9690493", "l": "RHOB binds effectors on endosomes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48852", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 = 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23622", "l": "AMP + deoxyamidinoproclavaminate + diphosphate + H(+) => ATP + N(2)-(2-carboxyethyl)-L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193981", "l": "CYP21A2 oxidises 17HPROG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19963", "l": "a 2'-deoxyribonucleoside 5'-phosphate + a ribonucleoside => a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218821", "l": "PDK1 phosphorylates PKC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-984689", "l": "Kinesin-7 is a dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047739", "l": "cephalosporin-C deacetylase activity"}, {"i": "RHEA:22596", "l": "cephalosporin C + H2O = acetate + deacetylcephalosporin C + H(+)"}, {"i": "EC:3.1.1.41", "l": "\"Cephalosporin-C deacetylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28079", "l": "2-hydroxyethylphosphonate + NAD(+) => H(+) + NADH + phosphonoacetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45331", "l": "7,8-dihydroneopterin <=> 7,8-dihydromonapterin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42232", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z)-octadecenoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15494", "l": "A + H2O + N2 => AH2 + nitrous oxide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102627", "l": "parthenolide 3beta-hydroxylase activity"}, {"i": "MetaCyc:RXN-15532"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55746", "l": "coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-Glu)(n) => coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017099", "l": "very-long-chain-acyl-CoA dehydrogenase activity"}, {"i": "REACT:R-HSA-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080095", "l": "phosphatidylethanolamine-sterol O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18789", "l": "D-glucosamine 6-phosphate = D-galactosamine 6-phosphate"}, {"i": "EC:5.1.3.42", "l": "\"D-glucosamine-6-phosphate 4-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-870538", "l": "TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11700", "l": "H(+) + NADPH + O2 + progesterone = H2O + NADP(+) + testosterone acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57343", "l": "3-hydroxy-L-kynurenine + S-adenosyl-L-methionine <=> 3-hydroxy-4-methyl-L-kynurenine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11521", "l": "(-)-menthol + UDP-alpha-D-glucose => (-)-menthyl beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797554", "l": "ABP1 binds SHANK proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27324", "l": "3-epi-6-deoxocathasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6-deoxotyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24161", "l": "D-galactose + O2 => D-galacto-hexodialdose + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.6", "l": "\"Chalcone isomerase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047378", "l": "acetylalkylglycerol acetylhydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75187", "l": "TRAIL:TRAIL receptor trimers bind FADD (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66127", "l": "2-oxobutanoate + L-histidine <=> (2S)-2-aminobutanoate + 3-(imidazol-5-yl)pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1605632", "l": "Both hexosaminidase A and B can cleave GalNAc from globoside (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607737", "l": "BCL10 oligomerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163625", "l": "Glucagon binds to Glucagon receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14580", "l": "(R)-carnitine <=> crotonobetaine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032478", "l": "EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1638845", "l": "CERK phosphorylates CERA to form C1P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18240", "l": "2,5-dihydroxybenzoate + O2 <=> 3-maleylpyruvate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13749", "l": "a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP"}, {"i": "EC:2.7.4.10", "l": "\"Nucleoside-triphosphate--adenylate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16968", "l": "(2E)-geranyl diphosphate <=> beta-myrcene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43903", "l": "dalpatein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O <=> beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalpatein + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-517674", "l": "p-S158,221-HuR binds mRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35692", "l": "(2S)-versicolorone + NADP(+) => 1'-hydroxyversicolorone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-888577", "l": "Synthesis of GABA by GAD2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39028", "l": "a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21113", "l": "globoside Gb3Cer (d18:1(4E)) + H2O => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0046923", "l": "ER retention sequence binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-378956", "l": "Luteinizing hormone is a heterodimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50801", "l": "glutathione + prostaglandin A2 => prostaglandin A2-S-(S)-glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36779", "l": "2-oxoglutarate + GDP-alpha-D-perosamine = GDP-4-dehydro-alpha-D-rhamnose + L-glutamate"}, {"i": "EC:2.6.1.102", "l": "\"GDP-perosamine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18863", "l": "a 5-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine => a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25338", "l": "H(+) + urea = isocyanate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22558", "l": "AH2 + oxaloacetate => (S)-malate + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41390", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate => 1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55545", "l": "L-lysyl-[citrate synthase] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "75.076548671259488", "identifiers": [{"i": "GO:0008094", "l": "ATP-dependent activity, acting on DNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40868", "l": "(9E)-octadecenoyl-CoA + FAD + H(+) => (2E,9E)-octadecadienoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445705", "l": "Release Of ADP From Myosin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32238", "l": "(6S)-NADPHX + ADP <=> AMP + H(+) + NADPH + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3296326", "l": "HCAR1 binds LACT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32562", "l": "(2E)-geranyl diphosphate <=> diphosphate + gamma-terpinene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53056", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = H(+) + isowyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8954056", "l": "E2F6 binds TFDP2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033813", "l": "deacetylcephalosporin-C acetyltransferase activity"}, {"i": "RHEA:23860", "l": "acetyl-CoA + deacetylcephalosporin C = cephalosporin C + CoA"}, {"i": "EC:2.3.1.175", "l": "\"Deacetylcephalosporin-C acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16123", "l": "3-(carbamoylamino)propanoate + H(+) => 5,6-dihydrouracil + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9006870", "l": "IL21 receptor STAT phosphorylation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56716", "l": "H2O + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein] = H(+) + S-disulfanyl-L-cysteinyl-[SoxY protein] + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853793", "l": "p-5Y-RET complexes bind GRB2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40865", "l": "FADH2 + trans-2-heptadecenoyl-CoA => FAD + H(+) + heptadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874080", "l": "SRC phosphorylates PTK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64876", "l": "H2O + UDP = H(+) + phosphate + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37554", "l": "3-dehydro-D-glucose 6-phosphate + L-glutamate <=> 2-oxoglutarate + D-kanosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17635", "l": "an alcohol + D-glucuronate => a beta-D-glucuronoside + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913360", "l": "GM-CSF receptor alpha subunit binds GM-CSF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16261", "l": "L-lysyl-[protein] + succinyl-CoA = CoA + H(+) + N(6)-succinyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48366", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+) => beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62583", "l": "ATP + D-cystine(out) + H2O <=> ADP + D-cystine(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948066", "l": "K63polyUb-IRAK1 dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61761", "l": "rebaudioside B + UDP-alpha-D-glucose => rebaudioside A + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47083", "l": "17beta-hydroxyestr-4-en-3-one + H(+) + NADPH <=> 17beta-hydroxy-5beta-estran-3-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65107", "l": "aculene D + L-prolyl-[peptidyl-carrier protein] <=> aculene B + holo-[peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592316", "l": "Initial activation of proMMP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45819", "l": "(S)-lactate + A <=> AH2 + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156910", "l": "Formation of eEF1B complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450031", "l": "Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9659820", "l": "RB1 translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33442", "l": "glyoxal + H2O + O2 <=> glyoxylate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2197691", "l": "WIP binds WASP,N-WASP, activating them (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47133", "l": "11-cis-retinal + H2O + NAD(+) => 11-cis-retinoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38132", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol => 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876472", "l": "NPC2 binds CHOL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683593", "l": "ATG7:ATG3:LC3 dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466392", "l": "NRF1:p-PPARGC1A, NRF2 bind the TFB2M promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432411", "l": "SLMB binds phosphorylated cytosolic PER, facilitating its ubiquitination (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15926", "l": "dihydrobunolol + NADP(+) => bunolol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204500", "l": "CyP60 chaperones Basigin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26048", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] => glyceollin II + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17649", "l": "acetyl-[ACP] + malonate = acetate + malonyl-[ACP]"}, {"i": "EC:2.3.1.187", "l": "\"Acetyl-S-ACP:malonate ACP transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810724", "l": "PI3 binds the bacterial surface (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017159", "l": "pantetheine hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18497", "l": "L-ribulose 5-phosphate = L-xylulose 5-phosphate"}, {"i": "EC:5.1.3.22", "l": "\"L-ribulose-5-phosphate 3-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033592", "l": "RNA strand annealing activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48309", "l": "2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O => (3Z)-6-oxohex-3-enoyl-CoA + formate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37577", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12441", "l": "H2O + L-saccharopine + NAD(+) => 2-oxoglutarate + H(+) + L-lysine + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19227", "l": "5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin] => glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26389", "l": "all-trans-beta-carotene + O2 = all-trans-10'-apo-beta-carotenal + beta-ionone"}, {"i": "EC:1.13.11.71", "l": "\"Carotenoid-9',10'-cleaving dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33205", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16451", "l": "CoA + H(+) + N(6')-acetylkanamycin B => acetyl-CoA + kanamycin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35975", "l": "2-oxoglutarate + AH2 + fumitremorgin B + 2 O2 = A + CO2 + H2O + succinate + verruculogen"}, {"i": "EC:1.14.11.38", "l": "\"Verruculogen synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54600", "l": "2-oxoglutarate + O2 + octanoyl-CoA = 2-hydroxyoctanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43569", "l": "3,6-anhydro-alpha-L-galactopyranose + H2O + NAD(+) => 3,6-anhydro-L-galactonate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49932", "l": "(3E,5Z)-octadienoyl-CoA = (2E,5Z)-octadienoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51769", "l": "2-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one + dimethylallyl diphosphate => 4-prenylphlormethylbutanophenone + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046919", "l": "pyruvyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29739", "l": "ATP + beta-maltose(out) + H2O = ADP + beta-maltose(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198513", "l": "Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928619", "l": "PAK1 binds RAC1:GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16928", "l": "(E)-caffeoyl-CoA + S-adenosyl-L-methionine <=> (E)-feruloyl-CoA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418868", "l": "Recruitment of Src and Fyn to DCC:FADK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38037", "l": "(4Z)-2-oxohept-4-enedioate => (2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate"}]}
{"type": "biolink:MolecularActivity", "ic": "64.857184446143066", "identifiers": [{"i": "GO:0022836", "l": "gated channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8941895", "l": "Formation of CDK4/6:CCND complexes (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3364014", "l": "Recruitment of SET1 methyltransferase complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32513", "l": "(3R,6R)-6-hydroxy-3-isopropenylheptanoate + H(+) => (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13016", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose <=> an alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878117", "l": "RUNX3 binds ZFHX3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47918", "l": "ADP + H(+) + N-hexanoyl-(4R)-hydroxysphinganine-1-phosphate => ATP + N-hexanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48742", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + phosphate => [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + O-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45825", "l": "H(+) + L-serine => CO2 + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13778", "l": "ATP + D-ribose 5-phosphate + NH4(+) => 5-phospho-beta-D-ribosylamine + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "75.848614326174683", "identifiers": [{"i": "GO:0016861", "l": "intramolecular oxidoreductase activity, interconverting aldoses and ketoses"}, {"i": "EC:5.3.1.-", "l": "\"Interconverting aldoses and ketoses\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2203479", "l": "STAB2 (FEEL-2) binds ligands (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43636", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}, {"i": "EC:2.3.1.286", "l": "\"Protein acetyllysine N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58294", "l": "25-substituted-cholesteryl beta-D-glucoside + N-dodecanoylsphing-4-enine => 25-substituted-cholesterol + beta-D-glucosyl-N-dodecanoylsphing-4E-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033452", "l": "GUG codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41138", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18937", "l": "an N-acyl-L-homoserine lactone + H2O = a carboxylate + L-homoserine lactone"}, {"i": "EC:3.5.1.97", "l": "\"Acyl-homoserine-lactone acylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195378", "l": "Homodimerization of VEGF proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008495", "l": "protoheme IX farnesyltransferase activity"}, {"i": "RHEA:28070", "l": "(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o"}, {"i": "EC:2.5.1.141", "l": "\"Heme o synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166753", "l": "Conversion of C4 into C4a and C4b (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106281", "l": "chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity"}, {"i": "RHEA:42036", "l": "chenodeoxycholate + NAD(+) = 7-oxolithocholate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43273", "l": "ganglioside GD3 + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GD2 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390930", "l": "5-HT2 receptor can bind serotonin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042013", "l": "interleukin-19 binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004727", "l": "prenylated protein tyrosine phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3769394", "l": "AKT phosphorylates CBY1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37332", "l": "H2O + L-methionyl-L-alanine => L-alanine + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56152", "l": "(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine = (9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983300", "l": "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63593", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19481", "l": "acetyl-CoA + succinyl-CoA = 3-oxoadipyl-CoA + CoA"}, {"i": "EC:2.3.1.174", "l": "\"3-oxoadipyl-CoA thiolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28050", "l": "H2O + NADP(+) = NAD(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32933", "l": "a cardiolipin + CMP + H(+) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2-diacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55759", "l": "2-oxoglutarate + an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + O2 <=> a 2-hydroxyornithine lipid + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949399", "l": "CAR translocates from the cytosol to the mitochondrial intermembrane space (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24182", "l": "CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] => 2-hydroxyisobutanoyl-CoA + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204861", "l": "Interaction of Tie2 and Shc1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66527", "l": "L-ascorbate(in) + monodehydro-L-ascorbate radical(out) <=> L-ascorbate(out) + monodehydro-L-ascorbate radical(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862380", "l": "HSD17B13 binds lipid droplets (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46743", "l": "cholesta-5,7,24-trien-3beta-ol + H(+) + NADPH <=> cholesta-5,24-dien-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.42", "l": "\"Guanosine-diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41383", "l": "H(+) + NADH + O2 + toluene <=> 4-methylphenol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54167", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine <=> a 5'-(N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693540", "l": "MRN activates ATM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24690", "l": "acetate + eugenol + NADP(+) = (E)-coniferyl acetate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65059", "l": "glycochenodeoxycholate + NADP(+) <=> 7-oxoglycolithocholate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791139", "l": "Expression of SRPR (SRP Receptor subunit alpha) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41797", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoylsphinganine => a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54673", "l": "(+)-kolavenyl diphosphate + H2O => (+)-kolavelool + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31714", "l": "beta-amyrin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 11-oxo-beta-amyrin + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43426", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964619", "l": "PAK1 binds ARHGEF6 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.26", "l": "\"Adenosylcobinamide-GDP ribazoletransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.92"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417890", "l": "P2Y5 receptor can bind to LPA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010347", "l": "L-galactose-1-phosphate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56747", "l": "2-oxoglutarate + L-arginyl-[protein] + O2 <=> (3R)-3-hydroxy-L-arginyl-[protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.99.5", "l": "\"Dissimilatory sulfite reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37037", "l": "2-oxopentanoate + H(+) + NADH + NH4(+) => H2O + L-2-aminopentanoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65206", "l": "(R)-3-hydroxybutanoate + CoA + H(+) => (3R)-3-hydroxybutanoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863472", "l": "DAB2 binds LRP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374665", "l": "DCC interaction with SIAH1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950225", "l": "Expression of Ras-related protein Rap-1b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170810", "l": "nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212642", "l": "L-Glutamine transport into neurons (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38947", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49209", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,24S-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801762", "l": "REG3A oligomerize to form a pore complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41920", "l": "3-oxooctadecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54870", "l": "butanoyl-[ACP] + NAD(+) => (2E)-butenoyl-[ACP] + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8873850", "l": "STARD5 binds DCA, LCA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944227", "l": "Association of procollagen type XXII (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008311", "l": "double-stranded DNA 3'-5' exodeoxyribonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34425", "l": "(+)-lariciresinol + H(+) + NADPH => (-)-secoisolariciresinol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11840", "l": "benzaldehyde + H2O + NAD(+) = benzoate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.28", "l": "\"Benzaldehyde dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21960", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + [protein]-disulfide + H(+) + H2O = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + [protein]-dithiol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004420", "l": "hydroxymethylglutaryl-CoA reductase (NADPH) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199050", "l": "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36070", "l": "Co-precorrin-6B + S-adenosyl-L-methionine <=> Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38123", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol = 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55814", "l": "2 5'-deoxyadenosine + a bacteriochlorophyllide f + 2 H(+) + 2 L-methionine => a bacteriochlorophyllide d + H2O + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43659", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CTP <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30569", "l": "5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate => 5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869683", "l": "oxPL binds LBP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28800", "l": "H2O + L-prolinylglycine => glycine + L-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111879", "l": "PIP2 hydrolysis (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33725", "l": "a 1,2-diacyl-sn-glycerol + N-tetracosanoylsphinganine-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-tetracosanoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21727", "l": "a nitrile + 2 H2O <=> a carboxylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35373", "l": "(beta-L-Ara4N)2-(Kdo)2-lipid A + 2 di-trans,octa-cis-undecaprenyl phosphate => 2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871193", "l": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62349", "l": "H(+) + NADPH + notoamide E + O2 => H2O + NADP(+) + notoamide C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198611", "l": "AKT phosphorylates IKKalpha (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.58"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171291", "l": "Folding and Oligomerization of ENV glycoprotein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052587", "l": "diacetyl reductase ((R)-acetoin forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417843", "l": "P2Y13 binds ADP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58639", "l": "N-(9Z-octadecenoyl)-(2S)-hydroxyglycine <=> (9Z)-octadecenamide + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682769", "l": "LGI2 binds ADAM22,23 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21488", "l": "dalnigrein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O = beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalnigrein + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.51"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033947", "l": "mannosylglycoprotein endo-beta-mannosidase activity"}, {"i": "MetaCyc:3.2.1.152-RXN"}, {"i": "EC:3.2.1.152", "l": "\"Mannosylglycoprotein endo-beta-mannosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111264", "l": "Addition of nucleotides between position +11 and +30 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168960", "l": "Collagen type XVII ectodomain shedding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27614", "l": "(2Z,6E)-farnesyl diphosphate + 10 isopentenyl diphosphate = di-trans,deca-cis-tridecaprenyl diphosphate + 10 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49756", "l": "H(+) + O2 + protoviolaceinate = CO2 + H2O + proviolacein"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47196", "l": "a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382058", "l": "Nck binds to the active PDGF receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031830", "l": "type 5A serotonin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48257", "l": "(2S)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53603", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57605", "l": "2 [Fe(II)-cytochrome b5] + a 1-tetracosanoyl-2-acyl-phosphoglycerolipid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a 1-[(15Z)-tetracos-15-enoyl]-2-acyl-phosphoglycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65028", "l": "(+)-pinoresinol + H2O + 2 oxidized [azurin] = (+)-6-hydroxypinoresinol + 2 H(+) + 2 reduced [azurin]"}, {"i": "EC:1.17.9.2", "l": "\"(+)-pinoresinol hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14804", "l": "(2R)-3-phosphoglycerate + ATP <=> (2R)-3-phospho-glyceroyl phosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64133", "l": "H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-L-phenylalanine => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44774", "l": "2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + H2O + NADP(+) => 2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031434", "l": "mitogen-activated protein kinase kinase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0106017", "l": "phosphatidylinositol-3,4-bisphosphate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618107", "l": "ATP binding to HSP90 triggers conformation change (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641229", "l": "TLE oligomerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102196", "l": "cortisol dehydrogenase activity"}, {"i": "MetaCyc:RXN-12085"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42773", "l": "guanosine(1405) in 16S rRNA + S-adenosyl-L-methionine => N(7)-methylguanosine(1405) in 16S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111930", "l": "Adenylate cyclase produces cAMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56810", "l": "adenosylcob(III)yrinate a,c-diamide + apo-[corrinoid adenosyltransferase] + triphosphate => ATP + cob(I)yrinate a,c diamide--[corrinoid adenosyltransferase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33540", "l": "ergosteryl ester + H2O => a carboxylate + ergosterol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52240", "l": "2 H2O + 2 Mn(2+) + O2 = 4 H(+) + 2 MnO2"}, {"i": "EC:1.16.3.3", "l": "\"Manganese oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450550", "l": "PKCalpha phosphorylates HuR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51419", "l": "a (2S,3R)-flavan-3-ol + 2 NADP(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47468", "l": "(2E,4E)-tetradecadienoyl-CoA = (3E,5Z)-tetradecadienoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140107", "l": "high-affinity potassium ion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57179", "l": "L-arginyl-[protein] + methylglyoxal <=> N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685542", "l": "Viral release (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63340", "l": "ATP + L-amino acyl-L-seryl-[protein] = (S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38443", "l": "a long chain fatty alcohol + an acyl-CoA = a wax ester + CoA"}, {"i": "EC:2.3.1.75", "l": "\"Long-chain-alcohol O-fatty-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29758", "l": "(R)-lipoate(in) <=> (R)-lipoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8979071", "l": "KDM6B binds iron (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23173", "l": "ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] => ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60440", "l": "H2O + methyl acetate = acetate + H(+) + methanol"}, {"i": "EC:3.1.1.114", "l": "\"Methyl acetate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20385", "l": "(2R,3R)-dihydroquercetin + H(+) + NADH + O2 = (2R,3R)-2,3-dihydrogossypetin + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16021", "l": "oxaloacetate = enol-oxaloacetate"}, {"i": "EC:5.3.2.2", "l": "\"Oxaloacetate tautomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43351", "l": "cholesteryl (9Z-octadecenoate)(in) <=> cholesteryl (9Z-octadecenoate)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41086", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16195", "l": "a (2R)-2-hydroxycarboxylate + a halide anion + H(+) => an (R)-2-haloacid + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14130", "l": "cholate + NADP(+) => 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48118", "l": "H(+) + N(5)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine => L-arginyl-[protein] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864569", "l": "WWOX binds TFAP2C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45604", "l": "D-glucaro-1,4-lactone = 5-dehydro-4-deoxy-D-glucarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876258", "l": "CBL monoubiquitinates InlB-bound MET (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20622", "l": "ATP + H2O + Zn(2+)(in) => ADP + H(+) + phosphate + Zn(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358791", "l": "Phosphorylation of USP8 by P-AKT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41643", "l": "3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41374", "l": "1-O-dodecyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-dodecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6790454", "l": "SUMOylation of XPC (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29882", "l": "ATP + H2O + L-arginine(out) <=> ADP + H(+) + L-arginine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102468", "l": "wogonin 7-O-glucuronosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236970", "l": "Proteasomal clevage of exogenous antigen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050403", "l": "trans-zeatin O-beta-D-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25974", "l": "4-acetamidobutanal + H2O2 + propane-1,3-diamine => H2O + N(8)-acetylspermidine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10706", "l": "AMP + diphosphate + L-valyl-tRNA(Val) => ATP + L-valine + tRNA(Val)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851933", "l": "MET phosphorylates GAB1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17917", "l": "[Glu(-Cys)](n)-Gly + glutathione + H(+) = [Glu(-Cys)](n+1)-Gly + glycine"}, {"i": "EC:2.3.2.15", "l": "\"Glutathione gamma-glutamylcysteinyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419645", "l": "Dimerization of LIMK1 by Hsp90 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853762", "l": "RET dimerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018462", "l": "4-(hydroxymethyl)benzenesulfonate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33762", "l": "a 3-oxo-fatty acyl-CoA + H(+) + NADPH <=> a 3-hydroxy-fatty acyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21730", "l": "GDP-alpha-D-mannuronate + 3 H(+) + 2 NADH => GDP-alpha-D-mannose + H2O + 2 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27338", "l": "2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin] => 15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990165", "l": "single-strand break-containing DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32521", "l": "(E)-2-methylgeranyl diphosphate + H(+) + S-adenosyl-L-homocysteine => (2E)-geranyl diphosphate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5362522", "l": "ALDHs oxidise atRAL to atRA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197187", "l": "ACS transforms to QUIN non-enzymatically (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58533", "l": "15alpha-stemmadenine intermediate I + H2O => akuammicine + formate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158982", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41567", "l": "aklavinone + dTDP-beta-L-rhodosamine <=> aclacinomycin T + dTDP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57026", "l": "D-xylulose 5-phosphate + dihydroxyacetone phosphate => apulose 4-phosphate + D-glyceraldehyde 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52010", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156910", "l": "Formation of eEF1B complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55033", "l": "an N-methylornithine lipid + S-adenosyl-L-methionine => an N,N-dimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66881", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 10-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622377", "l": "CEBPB mRNA is translated to yield CEBPB protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25435", "l": "beta-D-ribopyranose <=> beta-D-ribofuranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.24", "l": "\"(E3-independent) E2 ubiquitin-conjugating enzyme\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44346", "l": "ADP + dapdiamide A + H(+) + phosphate => ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29585", "l": "guanosine(out) + H(+)(in) => guanosine(in) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42949", "l": "cytidine(48) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419003", "l": "Interaction of Nectins with Afadin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187895", "l": "Engulfed CpG DNA binds to endosomal C-ter TLR9 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51082", "l": "19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5213466", "l": "RIPK3 is phosphorylated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.12"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938487", "l": "miR-20a binds RUNX1 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031758", "l": "Edg-5 sphingosine 1-phosphate receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.99.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11350", "l": "ADP + arsenite(out) + H(+) + phosphate => arsenite(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201634", "l": "Caspase-mediated cleavage of FADK 1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63067", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 3 CO2 + 4 CoA + tetraacetate lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33347", "l": "2-iminoacetate + H2O = glyoxylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19103", "l": "4-hydroxy-2-butynal + H(+) + NADH => 2-butyne-1,4-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879594", "l": "SLCO4C1 mediates the transport of digoxin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43614", "l": "5-methyluridine(341) in tmRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(341) in tmRNA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050598", "l": "taxane 13-alpha-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047059", "l": "polyvinyl alcohol dehydrogenase (cytochrome) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839067", "l": "Phosphorylation of BCR moiety of BCR-FGFR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16783", "l": "a fatty acid + CoA + H(+) => a fatty acyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700662", "l": "(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45844", "l": "(3R)-hydroxyoctanoyl-CoA + NADP(+) = 3-oxooctanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0051765", "l": "inositol tetrakisphosphate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66022", "l": "[collagen]-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O => H2O2 + L-lysyl-[collagen] + L-methionyl-[collagen]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425861", "l": "Activation of Protein Kinase C novel isoforms (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10769", "l": "(2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2 => (4S)-2,3-dehydroleucopelargonidin + CO2 + H(+) + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12803", "l": "ADP + H(+) + O-phospho-L-seryl-[tau protein] => ATP + L-seryl-[tau protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862300", "l": "LYZ binds bacterial peptidoglycan (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36502", "l": "2-dehydro-3-deoxy-L-rhamnonate + NAD(+) <=> 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "76.125169645393314", "identifiers": [{"i": "GO:0016812", "l": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides"}, {"i": "REACT:R-HSA-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Homo sapiens)"}, {"i": "EC:3.5.2.-", "l": "\"In cyclic amides\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848663", "l": "ADIPOQ trimer binds ADIPOR dimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112282", "l": "CAMK4 enters the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21184", "l": "dolichyl phosphate + GDP-alpha-D-mannose = dolichyl beta-D-mannosyl phosphate + GDP"}, {"i": "EC:2.4.1.83", "l": "\"Dolichyl-phosphate beta-D-mannosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66193", "l": "ATP + bilirubin-bisglucuronoside(in) + H2O => ADP + bilirubin-bisglucuronoside(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52903", "l": "3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide <=> 15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50181", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 => N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10301", "l": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate => (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52145", "l": "3-phosphonopyruvate + acetyl-CoA + H2O => (R)-2-(phosphonomethyl)malate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848338", "l": "PNPLA4 hydrolyzes TAG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55551", "l": "N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046363", "l": "FGFR4 kinase mutants are inhibited by PD170734 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63407", "l": "3,6-dichloropyridine-2,5-diol + FADH2 + O2 <=> 6-chloro-3-hydroxypyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14796", "l": "2-hydroxyadipate + NAD(+) <=> 2-oxoadipate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41443", "l": "(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 <=> (1R)-(2-amino-1-hydroxyethyl)phosphonate + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28365", "l": "dGTP + H2O <=> dGMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17140", "l": "prostaglandin H2 <=> thromboxane A2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60164", "l": "a guanosine in RNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18495", "l": "CoA + H(+) + N-benzoylglycine => benzoyl-CoA + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23041", "l": "2-oxobutanoate + acetyl-CoA + H2O => (R)-2-ethylmalate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43793", "l": "adenosine(645) in 25S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(645) in 25S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008839", "l": "4-hydroxy-tetrahydrodipicolinate reductase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64532", "l": "2 [Fe(II)-cytochrome b5] + an N-(1,2 saturated very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50018", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + octanoyl-4'-phosphopantetheine => H2O + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106375", "l": "deoxynucleoside triphosphate hydrolase activity"}, {"i": "RHEA:46148", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside + H(+) + triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028505", "l": "Activated NTRK2 recruits PI3K (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25963", "l": "benzoin + NADP(+) <=> benzil + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14788", "l": "RNA(n) + UTP <=> diphosphate + RNA(n)-3'-uridine ribonucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63225", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 => 2-[12-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl]-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62890", "l": "beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-D-glucose + GDP + H(+) => GDP-beta-L-fucose + lactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2002460", "l": "P4HB binds Collagen chains (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690404", "l": "Expression of SOX9 in testis differentiation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034647", "l": "histone H3-tri/di/monomethyl-lysine-4 demethylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22309", "l": "O2 + xylitol => D-xylose + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30226", "l": "2 [Fe(III)cytochrome c] + hydrogen sulfide <=> 2 [Fe(II)cytochrome c] + H(+) + sulfur"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25021", "l": "CTP + riboflavin = CDP + FMN + H(+)"}, {"i": "EC:2.7.1.161", "l": "\"CTP-dependent riboflavin kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46149", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O => a 2'-deoxyribonucleoside + H(+) + triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32741", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine => 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.2.1.1", "l": "\"Transketolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192123", "l": "CYP27A1 27-hydroxylates CHOL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3785711", "l": "Telomere shortening during replicative exhaustion (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008179", "l": "adenylate cyclase binding"}, {"i": "REACT:R-HSA-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35362", "l": "3-hydroxyisoheptadecanoyl-CoA <=> (2E)-15-methylhexadecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374662", "l": "Translocation of Ezrin to plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018798", "l": "RHOV binds GTP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814088", "l": "SYS1 binds AcM-ARFRP1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38739", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24224", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP(+) = 4-methylcatechol + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55230", "l": "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 [Fe(III)-cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18919", "l": "cholesta-5,7-dien-3beta-ol + 2 H2O + NADP(+) => 5alpha-cholest-7-en-3beta-ol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782859", "l": "TRMT5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23206", "l": "2-O-caffeoylglucarate + L-quinate => chlorogenate + D-glucarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46203", "l": "5alpha-androstane-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> 5alpha-androstane-3beta,6alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010307", "l": "acetylglutamate kinase regulator activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098770", "l": "FBXO family protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47123", "l": "docosanoate + glycine <=> H2O + N-docosanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5444523", "l": "Formation of MSH1:PMS2 Complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609860", "l": "Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444047", "l": "Receptor FFAR3 binds carboxylates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863973", "l": "Fusion of ERC and phagosome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18780", "l": "an alkylmercury + H(+) <=> an alkane + Hg(2+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10944", "l": "H2O + psi-UMP = phosphate + pseudouridine"}, {"i": "EC:3.1.3.96", "l": "\"Pseudouridine 5'-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25380", "l": "2-hydroxy-3-methylhexadecanoyl-CoA => 2-methylpentadecanal + formyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33369", "l": "D-glucose 6-phosphate(in) + L-histidyl-[protein] => D-glucose(out) + N(pros)-phospho-L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57068", "l": "3-oxoisoapionate + ATP = 3-oxoisoapionate 4-phosphate + ADP + H(+)"}, {"i": "EC:2.7.1.231", "l": "\"3-oxoisoapionate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32552", "l": "(2E)-geranyl diphosphate + H2O => (S)-alpha-terpineol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49731", "l": "2 H(+) + NADPH + 2 O2 + protoviolaceinate <=> CO2 + 2 H2O + NADP(+) + violacein"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875591", "l": "DOCK7 activates RAC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20862", "l": "(6R)-isopiperitenone + H(+) + NADH => (1S,6R)-isopiperitenol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030366", "l": "molybdopterin synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30563", "l": "dimethylallyl diphosphate + L-tryptophan = 7-(3-methylbut-2-enyl)-L-tryptophan + diphosphate"}, {"i": "EC:2.5.1.80", "l": "\"7-dimethylallyltryptophan synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202604", "l": "Formation of a heteromeric BMP receptor complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65713", "l": "alpha-D-glucose 1-phosphate + GDP-beta-L-galactose => beta-L-galactose 1-phosphate + GDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61276", "l": "H2O + L-ornithine + O2 = 5-amino-2-oxopentanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60402", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5226999", "l": "ADD1:ADD3 binds DMTN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018598", "l": "hydroxymethylsilanetriol oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6813740", "l": "GDE1 hydrolyzes GroPIns (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61815", "l": "3beta-hydroxyandrost-5-en-17-one + UDP-alpha-D-glucose <=> dehydroepiandrosterone 3-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5662606", "l": "MT3 binds zinc (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27480", "l": "2-oxoglutarate + O2 + thebaine <=> CO2 + formaldehyde + neopinone + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990482", "l": "sphingolipid alpha-glucuronosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018758", "l": "RHOH binds effectors at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193653", "l": "NGF homodimer binds to p75NTR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66890", "l": "8-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070996", "l": "type 1 melanocortin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19632", "l": "D-threo-isocitrate + NADP(+) <=> 2-oxoglutarate + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37929", "l": "8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O => (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39032", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654399", "l": "Activated FGFR2 binds FRS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000310", "l": "AURKA phosphorylates PLK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2219524", "l": "PDPK1 binds PIP2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49271", "l": "25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 23S,25-dihydroxy-24-oxocholecalciferol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874218", "l": "CREB3L4 translocates from the cytosol to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047181", "l": "tetrahydroxybenzophenone synthase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032791", "l": "lead ion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373342", "l": "CX3CR1 binds CX3CL1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17629", "l": "alpha,alpha-trehalose(in) = alpha,alpha-trehalose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9725206", "l": "IgE binds FCERI (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44184", "l": "D-sedoheptulose 7-phosphate = 2-epi-5-epi-valiolone + phosphate"}, {"i": "EC:4.2.3.152", "l": "\"2-epi-5-epi-valiolone synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70692", "l": "ornithine => putrescine + CO2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42908", "l": "S-adenosyl-L-methionine + uridine(1939) in 23S rRNA = 5-methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.190", "l": "\"23S rRNA (uracil(1939)-C(5))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37478", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047662", "l": "aminobenzoate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58604", "l": "FAD + 2 H(+) + NADH + O2 = FADH2-C4alpha-hydroperoxide + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28202", "l": "2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate = 2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin]"}, {"i": "EC:1.3.7.7", "l": "\"Ferredoxin:protochlorophyllide reductase (ATP-dependent)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52172", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15691", "l": "CO2 + propane-1,3-diamine => H(+) + L-2,4-diaminobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51709", "l": "D-altritol + NAD(+) => H(+) + keto-D-tagatose + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57444", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine"}, {"i": "EC:3.4.17.17", "l": "\"Tubulinyl-Tyr carboxypeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36187", "l": "1-O-alkyl-2-acyl-sn-glycerol + CDP-ethanolamine = 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35098", "l": "choline <=> acetaldehyde + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102272", "l": "homophytochelatin synthase activity (polymer-forming)"}, {"i": "MetaCyc:RXN-12528"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34056", "l": "festuclavine + NAD(+) => 6,8-dimethyl-6,7-didehydroergoline + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990244", "l": "histone kinase activity (H2A-T120 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203611", "l": "N-myristoylation of eNOS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56073", "l": "a 2-acylphloroglucinol + UDP-alpha-D-glucose => a 2-acylphloroglucinol 1-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004455", "l": "ketol-acid reductoisomerase activity"}, {"i": "RHEA:22068", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45361", "l": "H2O + N-(11Z-eicosenoyl)-sphinganine => (11Z)-eicosenoate + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030109", "l": "HLA-B specific inhibitory MHC class I receptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010327", "l": "acetyl CoA:(Z)-3-hexen-1-ol acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38090", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51771", "l": "2-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one + dimethylallyl diphosphate <=> 4-prenylphlormethylbutanophenone + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27548", "l": "3-hydroxyanthranilate + FAD + H(+) + H2O => anthranilate + FADH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55034", "l": "an N,N-dimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine => an N-methylornithine lipid + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14782", "l": "ATP + CoA + heptanedioate => 6-carboxyhexanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12239", "l": "H2O + NADP(+) + nicotinate <=> 6-hydroxynicotinate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.16.1", "l": "\"Spleen exonuclease\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177479", "l": "Axonal transport of NGF:Trk complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033984", "l": "indole-3-glycerol-phosphate lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57095", "l": "AH2 + S-(methylsulfanyl)glutathione <=> A + glutathione + methanethiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641205", "l": "RSPO:LGR binds ZNRF3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42803", "l": "15-cis-4,4'-diapophytoene + 3 FAD + 3 H(+) <=> all-trans-4,4'-diaponeurosporene + 3 FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16121", "l": "5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.34", "l": "\"2,4-dienoyl-CoA reductase ((2E)-enoyl-CoA-producing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18152", "l": "H2O + N-acetyl-D-galactosamine 6-phosphate <=> acetate + D-galactosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20490", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala) => 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33958", "l": "DIBOA + UDP-alpha-D-glucose <=> DIBOA beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64380", "l": "3 A + phytyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + 3 AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807581", "l": "HTN5, (HTN1, HTN3) binds fungal SSA1/SSA2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603784", "l": "PEX19:class I PMP binds PEX3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39045", "l": "docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76416", "l": "Benzene is hydroxylated to phenol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38656", "l": "6-tuliposide B => D-glucose + tulipalin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27272", "l": "H(+) + hexadecanoyl-CoA + NADPH => CoA + hexadecanal + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45498", "l": "(2R,3E)-phycocyanobilin + apo-[allophycocyanin alpha-subunit] => [allophycocyanin alpha-subunit]-Cys(84)-phycocyanobilin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411372", "l": "TCF/LEF:CTNNB1 promote transcription of AXIN2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27572", "l": "ADP + D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H(+) => ATP + D-glycero-alpha-D-manno-heptose 7-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61491", "l": "cytidine(50) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(50) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58501", "l": "glycine betaine + H(+) + NADH + O2 => glyoxylate + H2O + NAD(+) + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734713", "l": "ORC6 translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734730", "l": "ORC1 translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683735", "l": "CHEK2 is recruited to DNA DSBs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53623", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (-)-spiroviolene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205075", "l": "JNK phosphorylates BIM, BAD and other targets (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0120014", "l": "phospholipid transfer activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48591", "l": "2 H2O + 2 leukotriene A4 + O2 <=> 2 lipoxin B4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36812", "l": "acetyl-CoA + GDP-alpha-D-perosamine => CoA + GDP-N-acetyl-alpha-D-perosamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50090", "l": "21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218836", "l": "PTK2beta binds alphaVbeta3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981814", "l": "GalNAc alpha-2,6-sialyltransferase II can add a sialic acid to the T antigen at the alpha 6 position (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27755", "l": "H2O + methylglyoxal => (R)-lactate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951977", "l": "Acetylated RUNX3 binds to BRD2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848077", "l": "PTK6 phosphorylates STAP2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944265", "l": "Association of procollagen type IV (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034582", "l": "3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56614", "l": "H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] => L-cysteinyl-[protein] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10194", "l": "ADP + H(+) + phosphate + sulfate(in) => ATP + H2O + sulfate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37637", "l": "1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66347", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + ATP + H2O <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15611", "l": "5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+) => ATP + D-ribose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9646468", "l": "mTORC1 binds RHEB:GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46931", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol <=> a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419351", "l": "PAF receptor binds platelet activating factor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879930", "l": "STAT5 is recruited by JAK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047509", "l": "(R)-dehydropantoate dehydrogenase activity"}, {"i": "KEGG.REACTION:R03198"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804762", "l": "TP53 forms homotetramers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.382", "l": "\"Ketol-acid reductoisomerase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714483", "l": "RAC2 translocates to the ER membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51145", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + 2 O2 => (10,17)-dihydroperoxy-(7Z,11Z,13Z,15E,19Z)-docosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102807", "l": "cyanidin 3-O-glucoside 2''-O-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-8176"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373748", "l": "SEMA4D interacts with CD72 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48032", "l": "(2S)-2-methylbutanoyl-CoA + FAD + H(+) = (2E)-2-methylbut-2-enoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.22.1", "l": "\"Deoxyribonuclease II\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44309", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine => 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814831", "l": "TBC1D20 binds RAB1:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23410", "l": "2 H(+) + NADPH + precorrin-6A => NADP(+) + precorrin-6B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37299", "l": "H2O + L-alanyl-L-threonine = L-alanine + L-threonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8941312", "l": "ZCCHC6, ZCCHC11 are mRNA uridyltransferases (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189069", "l": "sucrose + H2O => glucose + fructose (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41162", "l": "1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803437", "l": "TP53 stimulates ZNF385A transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015576", "l": "sorbitol transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047093", "l": "4-hydroxyquinoline 3-monooxygenase activity"}, {"i": "RHEA:19325", "l": "H(+) + NADH + O2 + quinolin-4-ol = H2O + NAD(+) + quinoline-3,4-diol"}, {"i": "EC:1.14.13.62", "l": "\"4-hydroxyquinoline 3-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16561", "l": "H2O + squalene = hopan-22-ol"}, {"i": "EC:4.2.1.129", "l": "\"Squalene--hopanol cyclase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41148", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-532603", "l": "Nephrin mediated activation of N-WASP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9647980", "l": "mature RAS proteins translocate to plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45489", "l": "[C-phycocyanin beta-subunit]-Cys(84)-phycocyanobilin => (2R,3E)-phycocyanobilin + apo-[C-phycocyanin beta-subunit]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8857686", "l": "FITM1, FITM2 bind TAGs (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0033695", "l": "oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor"}, {"i": "EC:1.17.5.-", "l": "\"With a quinone or similar compound as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875443", "l": "USP8 deubiquitinates LRIG1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31382", "l": "H2O + pyrrole-2-carboxylate <=> 1H-pyrrole + hydrogencarbonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54590", "l": "H(+) + N(3)-methyluridine in 25S rRNA + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine in 25S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47385", "l": "4-acetoxyphenol + H2O => acetate + H(+) + hydroquinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65065", "l": "dimethylallyl diphosphate + siccayne => diphosphate + pestalodiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42890", "l": "(R)-3,5-bisphosphomevalonate + ADP + H(+) => (R)-3-phosphomevalonate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.30"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10277", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) => 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24931", "l": "H2O + L-cysteine = H(+) + hydrogen sulfide + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388900", "l": "Neurotensin receptors can bind neurotensins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14532", "l": "ADP + D-ribose 5-phosphate + H(+) <=> ADP-D-ribose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47538", "l": "isochenodeoxycholate + NADP(+) => 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43429", "l": "1,2-didecanoyl-sn-glycerol + ATP => 1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047131", "l": "saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362386", "l": "Glycosylation of Hh (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-202127", "l": "eNOS synthesizes NO (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65651", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(28-hydroxyoctacosanoyl)-sphing-4-enine <=> a diacylglycerol + N-(28-(9Z,12Z-octadecadienoyloxy)-octacosanoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43005", "l": "H(+) + O-carbamoyl-L-serine => 2-aminoprop-2-enoate + CO2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11253", "l": "H(+) + hydroxylamine + L-asparagine => beta-L-aspartylhydroxamate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801195", "l": "STEAP3 binds BNIP3L (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64945", "l": "dCTP + 2 H2O => dCMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42573", "l": "3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+) => 2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + CO2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050646", "l": "5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0004407", "l": "histone deacetylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902670", "l": "carbon dioxide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22821", "l": "3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose => 3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62768", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0015165", "l": "pyrimidine nucleotide-sugar transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008476", "l": "protein-tyrosine sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20996", "l": "(2Z,4E)-2-aminomuconate + H2O = (3E)-2-oxohex-3-enedioate + NH4(+)"}, {"i": "EC:3.5.99.5", "l": "\"2-aminomuconate deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61841", "l": "brassicasterol + UDP-alpha-D-glucose => brassicasterol 3-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17969", "l": "ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine"}, {"i": "EC:6.3.2.7", "l": "\"UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16569", "l": "2-oxoglutarate + L-lysyl-[collagen] + O2 = (5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate"}, {"i": "EC:1.14.11.4", "l": "\"Procollagen-lysine 5-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070835", "l": "chromium ion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9733973", "l": "Bile salts bind FABP6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12454", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+) => 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25232", "l": "L-arabinitol + NADP(+) <=> H(+) + L-arabinose + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.8", "l": "\"Glutathionylspermidine synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102171", "l": "DMNT synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199425", "l": "PHLPP dephosphorylates S473 in AKT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247836", "l": "Retromer recycles WLS to the Golgi (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803946", "l": "TP53 stimulates PLAGL1 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56361", "l": "13-deoxycarminomycin + H(+) + NADPH + O2 => 13-dihydrocarminomycin + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703435", "l": "FLT3 fusions activate STAT5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36772", "l": "beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-beta-L-fucose => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874685", "l": "CBL binds MET (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932351", "l": "KEAP1 facilitates ubiquitination of NFE2L2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58994", "l": "(E)-cinnamate + H(+) + H2O2 => (E)-cinnamaldehyde + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16959", "l": "GMP + H(+) => 3',5'-cyclic GMP + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051907", "l": "S-(hydroxymethyl)glutathione synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28846", "l": "choline(in) + H(+)(in) <=> choline(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31946", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25S)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694641", "l": "Viral release (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66900", "l": "acetyl-CoA + L-tryptophan + malonyl-CoA = CO2 + 2 CoA + cyclo-acetoacetyl-L-tryptophan + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5631885", "l": "PRDX1 overoxidizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696267", "l": "RND3 binds GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45920", "l": "16-hydroxyhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27951", "l": "L-phenylalanine(in) => L-phenylalanine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4655374", "l": "SUMOylation of DNMT3B with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52300", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37977", "l": "2-methyl-6-phytyl-1,4-benzene-1,4-diol + CO2 + diphosphate => H(+) + homogentisate + phytyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45287", "l": "eicosanoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-eicosanoyl-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61593", "l": "H2O + L-cysteinyl-[sulfatase] + S-adenosyl-L-methionine => 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + 2 H(+) + hydrogen sulfide + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47585", "l": "ganglioside GT2 (d18:1(4E)) + UDP-alpha-D-galactose => ganglioside GT1c (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373724", "l": "Nephrin binds NCK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63680", "l": "(7R,8S)-7,8-diammoniononanoate + CO2 = (7R,8S)-8-amino-7-(carboxyamino)nonanoate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2562564", "l": "Caspase-8 processing within TLR4 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237129", "l": "Acireductone is created (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21771", "l": "H2O + N-methyl-L-alanine + NADP(+) <=> H(+) + methylamine + NADPH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2430535", "l": "MASTL phosphorylates ENSA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69891", "l": "Phosphorylation and activation of CHEK2 by ATM (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64201", "l": "an N-(fatty acyl)-L-leucine + H2O => a fatty acid + L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158860", "l": "SULT1A1 dimer sulfonates NHABP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24111", "l": "H2O + N-methyl-2-oxoglutaramate <=> 2-oxoglutarate + methylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2214324", "l": "Collagen type VII dimerization (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429415", "l": "SYK binds to integrin alphaIIb beta3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009011", "l": "starch synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38605", "l": "2'-phospho-cyclic ADP-ribose + nicotinamide => NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2167942", "l": "Collagen type XIII ectodomain shedding (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665761", "l": "FMNL3 binds RHOC:GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5687107", "l": "MAPK4,6 translocate to nucleus (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693561", "l": "RAD51 binds BRCA2 at resected DNA DSBs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14400", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) <=> (4Z)-2-oxohept-4-enedioate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167192", "l": "Pol II elongation complex moves on the HIV-1 template as transcript elongates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380508", "l": "Translocation of NuMA to the centrosomes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55313", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25316", "l": "2-oxoglutarate + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate => L-2-acetamido-6-oxoheptanedioate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60467", "l": "2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) <=> 2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52440", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose = a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26361", "l": "L-tyrosine + NADPH + S-adenosyl-L-methionine = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+)"}, {"i": "EC:4.1.99.19", "l": "\"2-iminoacetate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.5", "l": "\"Carboxypeptidase C\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871266", "l": "YAP1 binds TEAD3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35886", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65405", "l": "butan-1-ol + hexanoyl-CoA => butyl hexanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38222", "l": "(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183052", "l": "CBL binds to GRB2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39492", "l": "(2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH => (11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-879459", "l": "F-actin capping protein is a heterodimer (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392749", "l": "Transport of L1 into endosomes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.62", "l": "\"Glycosylceramidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015653", "l": "glycine betaine:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53178", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an N-acylethanolamine + H(+) => H2O + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38025", "l": "6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol => gamma-tocotrienol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029456", "l": "RAC1 and CDC42 activate PAK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2255342", "l": "RALA exchanges GDP for GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49346", "l": "2,2-dihydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-hydroxyspirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607728", "l": "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12391", "l": "formononetin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50455", "l": "prostaglandin H3 <=> prostaglandin E3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57084", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O = a fatty acid + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37707", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54784", "l": "Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide = Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide"}, {"i": "EC:4.99.1.12", "l": "\"Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel chelatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209357", "l": "N-HH is palmitoylated by RASP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878243", "l": "HES1 gene transcription is inhibited by RUNX3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005484", "l": "SNAP receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61222", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-CDP + 1D-myo-inositol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22246", "l": "H(+) + kaempferol 3-O-beta-D-xyloside + UDP => kaempferol + UDP-alpha-D-xylose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210294", "l": "Interaction of PECAM-1 and SHP-2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16279", "l": "(indol-3-yl)acetate + H(+) + H2O2 => H2O + indole-3-acetaldehyde + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679029", "l": "C-ter TLR7 dimer binds HCQ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848338", "l": "PNPLA4 hydrolyzes TAG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19635", "l": "(5S)-5-amino-3-oxohexanoate + H(+) + NADH + NH4(+) => (3S,5S)-3,5-diaminohexanoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3244643", "l": "STING binds cyclic GMP-AMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62562", "l": "(4R)-perillyl alcohol + AH2 => (4R)-limonene + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55106", "l": "(3R)-hydroxyheptanoyl-[ACP] + NADP(+) => 3-oxoheptanoyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173626", "l": "Activation of C1r (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3364014", "l": "Recruitment of SET1 methyltransferase complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51835", "l": "ATP(in) + CoA(in) + H(+)(out) + tetracosanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + tetracosanoyl-CoA(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11385", "l": "(S)-2-hydroxydecanoate + NAD(+) => 2-oxodecanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800797", "l": "The PIDDosome activates CASP2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12042", "l": "3-(imidazol-5-yl)pyruvate + H(+) + NADPH => (S)-3-(imidazol-5-yl)lactate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41231", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56581", "l": "6-thioguanine + S-adenosyl-L-methionine => 6-methylthioguanine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52730", "l": "a 12-sulfojasmonate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + a 12-hydroxyjasmonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30073", "l": "acetate + butanoyl-CoA => acetyl-CoA + butanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.40"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937656", "l": "IL10 negatively regulates plasma membrane-associated inflammatory mediators (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63121", "l": "(11Z)-eicosenamide + H2O => (11Z)-eicosenoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070051", "l": "fibrinogen binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5660663", "l": "Caspase-8 cleaves IL1B precursor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682020", "l": "MRN complex binds shortened telomeres (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167217", "l": "Phospho-Shc dissociates from the TrkA receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2468040", "l": "Cohesin binds PDS5 and WAPAL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10371", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose <=> dTDP-4-dehydro-6-deoxy-D-galactose + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23406", "l": "diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate => (2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.22.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679266", "l": "Beclin-1 complex translocates to the ER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48437", "l": "H2O + pentanoate ester => an aliphatic alcohol + H(+) + pentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53851", "l": "NAD(+) + taurocholate <=> 7-oxo-taurodeoxycholate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22336", "l": "glycine betaine + L-homocysteine = L-methionine + N,N-dimethylglycine"}, {"i": "EC:2.1.1.5", "l": "\"Betaine--homocysteine S-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19388", "l": "UDP-alpha-D-glucose + vomilenine <=> H(+) + raucaffricine + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37725", "l": "1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphocholine + CoA => (9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15719", "l": "doxorubicin + H2O + NADP(+) => daunorubicin + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950591", "l": "JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74723", "l": "Endosome acidification (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034911", "l": "phthalate 3,4-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47674", "l": "2''-O-malonyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43576", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22032", "l": "3-oxalomalate = glyoxylate + oxaloacetate"}, {"i": "EC:4.1.3.13", "l": "\"Oxalomalate lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173705", "l": "C5b binds C6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26459", "l": "ethylnitronate + FMNH2 + O2 => acetaldehyde + FMN + 2 H(+) + H2O + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60297", "l": "L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54183", "l": "a long-chain fatty aldehyde + holo-[ACP] + NAD(+) <=> a long-chain fatty acyl-[ACP] + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008574", "l": "plus-end-directed microtubule motor activity"}, {"i": "MetaCyc:3.6.4.4-RXN"}, {"i": "EC:5.6.1.3", "l": "\"Plus-end-directed kinesin ATPase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218821", "l": "PDK1 phosphorylates PKC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14656", "l": "a nucleoside 3',5'-cyclic phosphate + H2O <=> a nucleoside 5'-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045439", "l": "isopenicillin-N epimerase activity"}, {"i": "KEGG.REACTION:R04147"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56104", "l": "2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2 = 4,4'-diaponeurosporenal + 2 A + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63604", "l": "[Pyr1]apelin-13 + H2O = [Pyr1]apelin-12 + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17325", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = (S)-2-succinylamino-6-oxoheptanedioate + CoA"}, {"i": "EC:2.3.1.117", "l": "\"2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005164", "l": "tumor necrosis factor receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29280", "l": "H(+) + menaquinol-8 + trimethylamine N-oxide => H2O + menaquinone-8 + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19178", "l": "L-lysine => (3S)-3,6-diaminohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37388", "l": "(9Z)-octadecenoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031798", "l": "type 1 metabotropic glutamate receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.102", "l": "\"C-terminal processing peptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49409", "l": "[(1->2)-beta-D-mannosyl](n) + phosphate => [(1->2)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34018", "l": "ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2 <=> ergosterol + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102027", "l": "S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32744", "l": "L-homocysteine + O-acetyl-L-serine => acetate + H(+) + L,L-cystathionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52058", "l": "12-hydroxyoctadecanoate + H(+) + hexadecanoate => 12-hexadecanoyloxy-octadecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1640164", "l": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51975", "l": "an L-polyhomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51811", "l": "(9Z)-octadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (9Z)-octadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10008", "l": "[protein]-dithiol + a hydroperoxide = [protein]-disulfide + an alcohol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578965", "l": "TNRC6A binds AGO2:miRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0023026", "l": "MHC class II protein complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30365", "l": "(2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 H(+) + 2 tricarballylate => fumonisin B1 + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30640", "l": "(R)-glycerate + GDP-alpha-D-mannose => (2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40529", "l": "2 a ubiquinone + 4 H(+)(out) + 2 H2O(in) => 2 a ubiquinol + 4 H(+)(in) + O2(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0030971", "l": "receptor tyrosine kinase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31792", "l": "H2O + tuberculosinyl diphosphate => (13S)-edaxadiene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964619", "l": "PAK1 binds ARHGEF6 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36117", "l": "O-methyl gibberellin A3 + S-adenosyl-L-homocysteine => gibberellin A3 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43489", "l": "7(1)-hydroxychlorophyll a + NAD(+) => chlorophyll b + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419003", "l": "Interaction of Nectins with Afadin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11631", "l": "a 2-oxocarboxylate + H(+) <=> an aldehyde + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32699", "l": "(2E,6E)-farnesyl diphosphate = beta-sesquiphellandrene + diphosphate"}, {"i": "EC:4.2.3.123", "l": "\"Beta-sesquiphellandrene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62201", "l": "2 [Fe(III)cytochrome c] + ethanol => 2 [Fe(II)cytochrome c] + acetaldehyde + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008692", "l": "IL37(?-218) binds SMAD3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10130", "l": "all-trans-neoxanthin => all-trans-violaxanthin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65561", "l": "2-oxoglutarate + L-kynurenine => H2O + kynurenate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296127", "l": "Activation of voltage gated Potassium channels (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50588", "l": "13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19018", "l": "(6S)-NADHX + ATP => ADP + H(+) + NADH + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805620", "l": "KAT6A and PML bind TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9706399", "l": "RHOBTB3 hydrolyzes ATP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985201", "l": "ABCE1 binds RNASEL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39396", "l": "3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.138"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2247513", "l": "STAB1:ligand is endocytosed (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420121", "l": "SFKs phosphorylate PLCG1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913371", "l": "GM-CSF receptor alpha:GM-CSF binds Bc (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28028", "l": "[thioredoxin]-dithiol + UDP => [thioredoxin]-disulfide + dUDP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41905", "l": "3-oxohexadecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33085", "l": "5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine => dehypoxanthine futalosine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5223313", "l": "ABCD4:LMBRD1 transports Cbl from lysosomal lumen to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717392", "l": "CALHM1:CALHM3 transports ATP from the cytosol to the extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44065", "l": "hexadecanoyl-CoA + octan-1-ol => CoA + octyl hexadecanoyl"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450474", "l": "MK2 phosphorylates BRF1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038025", "l": "reelin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60083", "l": "4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2 <=> 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10901", "l": "an aromatic L-alpha-amino acid + glyoxylate => an aromatic oxo-acid + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37091", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(10Z,13Z,16Z)-docosatrienoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62472", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-nonadioyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69074", "l": "Formation of Processive Complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102279", "l": "lecithin:11-cis retinol acyltransferase activity"}, {"i": "RHEA:17469", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester + apo--[retinol-binding protein]"}, {"i": "MetaCyc:RXN-12563"}, {"i": "EC:2.3.1.135", "l": "\"Phosphatidylcholine--retinol O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22042", "l": "formate + L-aspartate => H2O + N-formyl-L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011143", "l": "ROBO3.1 expression is stimulated by LHX2,(LHX9) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5663050", "l": "DHI and DHICA polymerise forming eumelanin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442387", "l": "ZIP8 mediates zinc influx into cells (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27843", "l": "9H-carbazole + H(+) + NADPH + O2 => 2'-aminobiphenyl-2,3-diol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028583", "l": "Phosphorylation of YAP by LATS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247847", "l": "WLS is endocytosed to the early endosome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21894", "l": "D-arabinono-1,4-lactone + H(+) + NADPH => D-arabinose + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35918", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47996", "l": "1,6-dihydro-beta-NAD + H(+) + O2 = H2O2 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071253", "l": "connexin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213192", "l": "Hemidesmosome formation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18193", "l": "H2O + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] = (S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62832", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc]oxy}nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64453", "l": "L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-methionine => 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50940", "l": "L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe) = cyclo(L-phenylalanyl-L-leucyl) + H(+) + tRNA(Leu) + tRNA(Phe)"}, {"i": "EC:2.3.2.20", "l": "\"Cyclo(L-leucyl-L-phenylalanyl) synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45991", "l": "3,17-dihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMNH2 + O2 <=> 3,4,17-trihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMN + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418874", "l": "Recruitment and activation of N-WASP by Cdc42 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11870", "l": "D-ribulose + H(+) + NADPH => D-arabinitol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35460", "l": "cholesterol + NAD(+) => cholest-5-en-3-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36206", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + ethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41115", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50076", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69891", "l": "Phosphorylation and activation of CHEK2 by ATM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.21", "l": "\"Catalase peroxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0047606", "l": "hydroxynitrilase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11073", "l": "anthranilate + 3 H(+) + NADPH + O2 => catechol + CO2 + NADP(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50732", "l": "4-hydroxyphenylacetonitrile + O2 + reduced [NADPH--hemoprotein reductase] = (S)-4-hydroxymandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42366", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 a 2-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40012", "l": "(+)-copalyl diphosphate + H2O => diphosphate + manool"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19887", "l": "(S)-scoulerine + H(+) + H2O2 => (S)-reticuline + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19738", "l": "4-(gamma-L-glutamylamino)butanoate + H2O => 4-aminobutanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806613", "l": "Keratin tetramers bind to form unit length filaments (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14868", "l": "S-adenosyl-L-methionine + tyramine <=> H(+) + N-methyltyramine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63518", "l": "biphenyl-2,2',3,3'-tetraol + H2O + NAD(+) => biphenyl-2,2',3-triol + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202709", "l": "JAM2 dimerises (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49916", "l": "(R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in) = (R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63233", "l": "(2E)-octenoyl-CoA + H(+) + NADH => NAD(+) + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49765", "l": "ethylenediaminetriacetate + FMNH2 + O2 => ethylenediaminediacetate + FMN + glyoxylate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53993", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28637", "l": "(+)-5-epi-aristolochene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28809", "l": "L-cysteinylglycine + L-glutamate => glutathione + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392187", "l": "Activated P2Y purinoceptor 12 binds G-protein Gi (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5333678", "l": "CPNEs bind PL (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416698", "l": "SEMA5A binds to PLXNB3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20328", "l": "N-hydroxy-4-acetylaminobiphenyl <=> N-acetoxy-4-aminobiphenyl"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39139", "l": "(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O = (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35562", "l": "H(+) + menaquinone-7 + NADH <=> menaquinol-7 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58928", "l": "(3R,4R)-7,2',4'-trihydroxyisoflavanol = (6aR,11aR)-3,9-dihydroxypterocarpan + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31388", "l": "(S)-2,3-epoxysqualene => alpha-amyrin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683774", "l": "p-T68-CHEK2 dimerizes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052921", "l": "acetone-cyanohydrin acetone-lyase (cyanide-forming) activity"}, {"i": "RHEA:11932", "l": "2-hydroxy-2-methylpropanenitrile = acetone + hydrogen cyanide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45674", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12893", "l": "prostaglandin H2 = prostaglandin E2"}, {"i": "EC:5.3.99.3", "l": "\"Prostaglandin-E synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14439", "l": "6-amino-2-oxohexanoate + H2O2 + NH4(+) => H2O + L-lysine + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008856", "l": "exodeoxyribonuclease X activity"}, {"i": "MetaCyc:3.1.22.5-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21050", "l": "ADP + gamma-glutamyl-isopropylamide + H(+) + phosphate => ATP + isopropylamine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814555", "l": "Integrator complex processes the 3' end of snRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "69.997272734060871", "identifiers": [{"i": "GO:0097367", "l": "carbohydrate derivative binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74885", "l": "GUCYs converts GTP to cGMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24379", "l": "apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin <=> AMP + diphosphate + H(+) + holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4332235", "l": "CBL binds TGFBR2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928640", "l": "PAKs phosphorylate MLC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20426", "l": "2-oxoglutarate + ATP + hydrogencarbonate => (S)-oxalosuccinate + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209815", "l": "Tyrosine is monoiodinated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2002401", "l": "Association of procollagen type XVIII (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63380", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-2-acetyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396402", "l": "NOTCH1 PEST domain mutants bind promoters of HEY genes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070320", "l": "inward rectifier potassium channel inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159771", "l": "Furin cleaves pro-protein C to protein C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62661", "l": "2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol => (2'R)-atrovenetin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49955", "l": "(10aS)-10,10a-dihydrophenazine-1-carboxylate <=> 5,10-dihydrophenazine 1-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36861", "l": "3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoA => (17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21221", "l": "L-dopa + O2 => 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13028", "l": "3-methyl-(2E)-butenoyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] <=> N(6)-biotinyl-L-lysyl-[protein] + trans-3-methylglutaconyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381727", "l": "RAP1A exchanges GDP for GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-215526", "l": "CYP4F3 20-hydroxylates LTB4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047917", "l": "GDP-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44947", "l": "1-O-alkyl-3-acyl-sn-glycerol + H2O <=> 1-O-alkyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810724", "l": "PI3 binds the bacterial surface (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001621", "l": "G protein-coupled ADP receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047309", "l": "dihydroxyphenylalanine transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696958", "l": "USP44 deubiquitinates CDC20 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.2.1.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72697", "l": "Start codon recognition (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12230", "l": "AMP + diphosphate + H(+) + L-asparagine + L-glutamate => ATP + H2O + L-aspartate + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38521", "l": "(9Z)-octadecenoate + 2-octadecanoylglycerol + H(+) => 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30338", "l": "CTP + H(+) + H2O <=> NH4(+) + UTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41217", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43515", "l": "2-(dihydroxymethyl)-5-formylfuran + O2 <=> 2-carboxy-5-formylfuran + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20709", "l": "ATP + erythritol => ADP + D-erythritol 4-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20687", "l": "H(+) + keto-D-tagatose + NADH => galactitol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24248", "l": "glyoxylate + L-alanine = glycine + pyruvate"}, {"i": "EC:2.6.1.44", "l": "\"Alanine--glyoxylate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029690", "l": "Caspase-6 translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43635", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) <=> an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102988", "l": "9,12-cis-hexadecadienoic acid delta 15 desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56456", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = 12-epi-fischerindole U"}, {"i": "EC:5.5.1.33", "l": "\"12-epi-fischerindole U synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13813", "l": "benzene + H(+) + NADH + O2 = cis-1,2-dihydrobenzene-1,2-diol + NAD(+)"}, {"i": "EC:1.14.12.3", "l": "\"Benzene 1,2-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030351", "l": "inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity"}, {"i": "REACT:R-HSA-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45147", "l": "3-(methylsulfanyl)acryloyl-CoA + 2 H2O <=> acetaldehyde + CO2 + CoA + methanethiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429683", "l": "CERT:ceramide [ER] => ceramide [Golgi] + CERT [ER] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42732", "l": "guanosine(527) in 16S rRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.170", "l": "\"16S rRNA (guanine(527)-N(7))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381704", "l": "G(s):GTP activates Adenylyl cyclase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876789", "l": "CARNMT1 methylates CARN to Anserine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25396", "l": "(9Z,12Z)-octadecadienoate + O2 => (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102710", "l": "D-inositol-3-phosphate glycosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215295", "l": "USP7 deubiquitinates MDM2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47897", "l": "6-sulfo-D-quinovose + NAD(+) => 6-deoxy-6-sulfo-D-glucono-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613498", "l": "Unwinding of DNA for the nascent HIV-1 transcript (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20864", "l": "alpha,alpha-trehalose 6-phosphate + phosphate = beta-D-glucose 1-phosphate + D-glucose 6-phosphate"}, {"i": "EC:2.4.1.216", "l": "\"Trehalose 6-phosphate phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2129353", "l": "Tropoelastin associates with microfibrils (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24437", "l": "H2 + methanophenazine => dihydromethanophenazine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655315", "l": "Activated FGFR3 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54277", "l": "2-oxoglutarate + L-aspartyl-[protein] + O2 => (3S)-3-hydroxy-L-aspartyl-[protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168883", "l": "Haptoglobin:Hemoglobin binds CD163 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64350", "l": "deacetylpyripyropene E => 2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14809", "l": "phenol + S-adenosyl-L-methionine = anisole + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.25", "l": "\"Phenol O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57025", "l": "apulose 4-phosphate + D-glyceraldehyde 3-phosphate => D-xylulose 5-phosphate + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2248891", "l": "Active ARSA translocates to the lysosome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851298", "l": "GPR143 binds L-Dopa (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52235", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 <=> 3 A + Fe(2+) + 3 H2O + mycobilin a"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28423", "l": "(1E,2S)-2-methylbutanal oxime + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2-methylbutanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46829", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35474", "l": "(+)-6a-hydroxymaackiain + S-adenosyl-L-methionine <=> (+)-pisatin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28098", "l": "ATP + GDP = AMP + guanosine 3',5'-bis(diphosphate)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57172", "l": "(S)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15460", "l": "cis-1,2-dihydrobenzene-1,2-diol + NAD(+) <=> catechol + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047445", "l": "3-hydroxy-3-isohexenylglutaryl-CoA lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112042", "l": "Opioid binds MOR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141437", "l": "Formation of the MCC complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47715", "l": "trans-3-hydroxy-L-proline <=> cis-3-hydroxy-D-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707594", "l": "Hemes bind LY96 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-517674", "l": "p-S158,221-HuR binds mRNA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56869", "l": "(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA => (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40769", "l": "(20S)-ginsenoside Rg1 + D-xylose => (20S)-ginsenoside R1 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23311", "l": "(E)-sinapoyl-CoA + D-glucarate <=> 2-O-[(E)-sinapoyl]-D-glucarate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380311", "l": "Recruitment of Plk1 to centrosomes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028724", "l": "AMOT proteins bind YAP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106367", "l": "dGTP dependent (deoxy)nucleoside -phosphate kinase activity"}, {"i": "RHEA:62128", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dGTP = a 2'-deoxyribonucleoside 5'-diphosphate + dGDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2426566", "l": "Interaction of DAP12 and CLM7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43016", "l": "an S-alkyl-L-cysteine = 2-aminoprop-2-enoate + an alkyl thiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201608", "l": "Caspase-mediated cleavage of alpha adducin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29530", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14848", "l": "L-aspartate 4-semialdehyde + pyruvate <=> (S)-2,3-dihydrodipicolinate + H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58638", "l": "(9Z)-octadecenamide + glyoxylate => N-(9Z-octadecenoyl)-(2S)-hydroxyglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13181", "l": "ATP + H2O + nitrate(out) = ADP + H(+) + nitrate(in) + phosphate"}, {"i": "EC:7.3.2.4", "l": "\"ABC-type nitrate transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35254", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O <=> ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36700", "l": "3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP => 8-desmethylnovobiocic acid + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685603", "l": "SAP and EAT2 binds SLAMF6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981728", "l": "Factor H binds to membrane-associated C3b (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205319", "l": "Interaction of APS and p-KIT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071566", "l": "UFM1 activating enzyme activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852337", "l": "GTSE1 binds TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24423", "l": "H2O + N-terminal N-formyl-L-methionyl-[peptide] <=> formate + N-terminal L-methionyl-[peptide]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46936", "l": "(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = ATP + H(+) + L-2-aminoadipate + NADPH"}, {"i": "EC:1.2.1.95", "l": "\"L-2-aminoadipate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66597", "l": "O2 + 2 tyramine => 2 dopamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202604", "l": "Formation of a heteromeric BMP receptor complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694308", "l": "3a is externalized together with membrane structures (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140488", "l": "heme receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28488", "l": "Fe(2+)(out) => Fe(2+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25235", "l": "N-acetyl-beta-neuraminate => N-acetyl-alpha-neuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53342", "l": "H(+) + NADH + uridine(20) in tRNA => 5,6-dihydrouridine(20) in tRNA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033490", "l": "TYSND1 cleaves PHYH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10005", "l": "benzyl isothiocyanate => benzyl thiocyanate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849857", "l": "KLK5 cleaves and activates CELA2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168896", "l": "Binding of NS1 to PKR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605535", "l": "Expression of SIRT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948569", "l": "miR-19b microRNA binds PTEN mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42680", "l": "2 hercynine + 2 L-selenocysteine + O2 = 2 H2O + 2 hercynylselenocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26171", "l": "3-fumarylpyruvate + H2O <=> fumarate + H(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810357", "l": "Fillagrin and keratin intermediate filaments polymerise forming a network (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64316", "l": "2 dihydrogeodin + 2 H(+) + O2 = 2 (+)-geodin + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432295", "l": "GPVI binds Fyn and Lyn (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429815", "l": "Formation Of Bloc-1 Complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33337", "l": "1,2-dioctadecanoyl-sn-glycerol + phosphate => 1,2-dioctadecanoyl-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32156", "l": "7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine => adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71050", "l": "Trimerization of the FASL:FAS receptor complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0070025", "l": "carbon monoxide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174235", "l": "Association of Emi1 with Cdc20 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730858", "l": "Autophosphorylation of BTK/ITK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047392", "l": "CMP-N-acylneuraminate phosphodiesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200143", "l": "AKT phosphorylates AKT1S1 (PRAS40) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65785", "l": "2 H(+) + monuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-(4-chlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53571", "l": "12,13-epoxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-12,13-epoxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "81.790986234327661", "identifiers": [{"i": "GO:0001099", "l": "basal RNA polymerase II transcription machinery binding"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0097603", "l": "temperature-gated ion channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18095", "l": "H(+) + NADPH + uracil => 5,6-dihydrouracil + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876868", "l": "ECE1 cleaves EDN1(53-90) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805785", "l": "AKT phosphorylates PHF20 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665767", "l": "Activated FMNL3 binds G-actin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42540", "l": "uridine(13) in tRNA = pseudouridine(13) in tRNA"}, {"i": "EC:5.4.99.27", "l": "\"tRNA pseudouridine(13) synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63129", "l": "H2O + N-docosanoyl-ethanolamine => docosanoate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53186", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13054", "l": "L-phenylalanine + pyruvate => 3-phenylpyruvate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42203", "l": "corticosterone + NADP(+) <=> 11-dehydrocorticosterone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32903", "l": "calciol + O2 + reduced [NADPH--hemoprotein reductase] = calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.24", "l": "\"Vitamin D 25-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202721", "l": "JAM2 binds JAM3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418845", "l": "Activation of caspase-3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66301", "l": "an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose => an alpha-D-mannosylinositol-1-phosphodihydroceramide + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21799", "l": "dTDP-beta-L-rhamnose + NADP(+) <=> dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1299359", "l": "Activation of TALK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23032", "l": "2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate"}, {"i": "EC:6.3.3.1", "l": "\"Phosphoribosylformylglycinamidine cyclo-ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9619376", "l": "CAMK1 binds calmodulin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033808", "l": "6'-deoxychalcone synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033797", "l": "selenate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250972", "l": "botG HC transports botG LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090554", "l": "phosphatidylcholine floppase activity"}, {"i": "RHEA:38583", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34481", "l": "15-cis-phytoene + diphosphate => (1R,2R,3R)-prephytoene diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420117", "l": "VEGFR2 autophosphorylates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39406", "l": "(2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH <=> (19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14000", "l": "3-methyl-2-oxobutanoate + CoA + NAD(+) <=> 2-methylpropanoyl-CoA + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19497", "l": "H(+) + L-aspartate = beta-alanine + CO2"}, {"i": "EC:4.1.1.11", "l": "\"Aspartate 1-decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20602", "l": "formaldehyde + mycothiol + NAD(+) => H(+) + NADH + S-formylmycothiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59065", "l": "demethylluteothin + S-adenosyl-L-methionine => luteothin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692749", "l": "CDC14A,B bind MAPK6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54947", "l": "3-oxo-(5Z)-dodecenoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-(5Z)-dodecenoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102422", "l": "curcumin-4'-O-beta-D-gentiotrioside 1,6-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-13814"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23442", "l": "4-hydroxybenzoate + chloride + H(+) => 4-chlorobenzoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451311", "l": "Activation of Ca-permeable Kainate receptors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41780", "l": "beta-D-Gal-(1<->1')-Cer + CMP-N-acetyl-beta-neuraminate = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265166", "l": "Exocytosis of Insulin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21762", "l": "(3R)-3-hydroxybutanoyl-CoA => (3S)-3-hydroxybutanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10444", "l": "(S)-reticuline + S-adenosyl-L-methionine = (S)-laudanine + H(+) + S-adenosyl-L-homocysteine"}, {"i": "RHEA:38907", "l": "(R)-reticuline + S-adenosyl-L-methionine = (R)-laudanine + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.291", "l": "\"(R,S)-reticuline 7-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0016175", "l": "superoxide-generating NAD(P)H oxidase activity"}, {"i": "REACT:R-HSA-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68610", "l": "Formation of ORC(2-5) complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31716", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 11alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35996", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59821", "l": "2 ATP => adenosine 3'-diphosphate,5'-triphosphate + AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709317", "l": "CO binds to free ferrohemoglobin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1006169", "l": "Factor H binds host cell surface markers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37411", "l": "aklavinone + NADP(+) = aklaviketone + 2 H(+) + NADPH"}, {"i": "EC:1.1.1.362", "l": "\"Aklaviketone reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43281", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52167", "l": "O2 + phenylacetonitrile + reduced [NADPH--hemoprotein reductase] <=> (R)-mandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1299318", "l": "Activation of TASK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62216", "l": "isoepoxydon + NADP(+) = H(+) + NADPH + phyllostine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62715", "l": "betaenone C + H(+) + NADPH + O2 <=> H2O + NADP(+) + stemphyloxin I"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-549322", "l": "OCT1 transports organic cations out of hepatic cells (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009389", "l": "dimethyl sulfoxide reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015277", "l": "kainate selective glutamate receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21468", "l": "dTDP-alpha-D-mycaminose + tylactone = 5-O-beta-D-mycaminosyltylactone + dTDP + H(+)"}, {"i": "EC:2.4.1.316", "l": "\"Tylactone mycaminosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27544", "l": "4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde => methanol + N,N-dimethyl-4-nitrosoaniline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23687", "l": "(S)-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] <=> allocryptopine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33398", "l": "H2O + N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester <=> GMP + N(alpha)-acetyl-L-lysine methyl ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9032798", "l": "DOCK3 activates RAC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218814", "l": "PAK2 autophorylates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202164", "l": "Translocation of PDK1 to Plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30044", "l": "fumarate + L-aspartate => iminosuccinate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43758", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18] => acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13208", "l": "a monosaccharide 1-phosphate + H(+) + UTP <=> a UDP-monosaccharide + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177942", "l": "EGFR binds EGF ligand (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62194", "l": "H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase] => O2 + peregrinol + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26118", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + epi-cedrol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33211", "l": "1,4-dihydroxy-2-naphthoate + all-trans-heptaprenyl diphosphate + H(+) = 2-demethylmenaquinol-7 + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606324", "l": "Recruitment TBK1 to dsDNA:ZBP1 followed by its activation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177920", "l": "Binding of GRB2 to GAB1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672957", "l": "PP2A dephosphorylates KSR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450088", "l": "GLUT1 tetramer binds 4xATP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176175", "l": "Stalling of DNA replication fork and RPA binding (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871266", "l": "YAP1 binds TEAD3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32621", "l": "H(+) + NADPH + sepiapterin => L-threo-7,8-dihydrobiopterin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47539", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH <=> isochenodeoxycholate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388503", "l": "Oxytocin receptor bind oxytocin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867047", "l": "PTPN3 dephosphorylates EPS15 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43624", "l": "2-aminomalonate semialdehyde + H(+) = aminoacetaldehyde + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38832", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.78"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50776", "l": "hexanal + NADP(+) = (E)-hex--2-enal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24614", "l": "estrone + H(+) + NADH => 17beta-estradiol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391157", "l": "p-4Y-SIRPA:CD47 binds SKAP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46040", "l": "2'-deoxycytidine + ATP = ADP + dCMP + H(+)"}, {"i": "EC:2.7.1.74", "l": "\"Deoxycytidine kinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102706", "l": "butein:oxygen oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351894", "l": "Caspase mediated cleavage of BAP31 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16504", "l": "H2O + sn-glycero-3-phospho-1D-myo-inositol <=> H(+) + myo-inositol + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23267", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NADP(+) <=> 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47332", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55395", "l": "adenosine in mRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine in mRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62658", "l": "2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol + diphosphate => 2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48081", "l": "abieta-8,11,13-triene + O2 + reduced [NADPH--hemoprotein reductase] => ferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37695", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA = 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047353", "l": "N-methylphosphoethanolamine cytidylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64639", "l": "benzoyl-CoA + butan-1-ol <=> butyl benzoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63721", "l": "losartan + UDP-alpha-D-glucuronate => losartan-2-N-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1973968", "l": "Beta-defensins 4A and 103 bind CCR2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018495", "l": "2-hydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46134", "l": "25-hydroxycholesterol + H2O + NADP(+) => cholesterol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111962", "l": "PDE4A,C,D hydrolyse cAMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53928", "l": "a tertiary amine + S-adenosyl-L-methionine = a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.49", "l": "\"Amine N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696268", "l": "RND3 binds effectors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033222", "l": "xylose binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57614", "l": "9 CO2 + 9 CoA + dihydro-ML-236C-[compactin nonaketide synthase] + 6 H2O + 11 NADP(+) => 20 H(+) + holo-[compactin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59321", "l": "D-cellobiono-1,5-lactone + H2O => 4-O-beta-D-glucopyranosyl-D-gluconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166542", "l": "beta-NGF dimer binds to TrkA receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693347", "l": "HTR1A binds 5HT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015552", "l": "propionate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9006870", "l": "IL21 receptor STAT phosphorylation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47685", "l": "[(1->2)-beta-D-glucosyl](n) + phosphate => [(1->2)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37646", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15193", "l": "dGTP + H2O = 2'-deoxyguanosine + H(+) + triphosphate"}, {"i": "EC:3.1.5.1", "l": "\"dGTPase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11935", "l": "2-hydroxy-2-methylpropanenitrile <=> acetone + hydrogen cyanide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.3.1", "l": "\"Citrate (Si)-synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004165", "l": "dodecenoyl-CoA delta-isomerase activity"}, {"i": "REACT:R-HSA-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043958", "l": "acryloyl-CoA reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66314", "l": "a D-mannosyl-alpha-1->6-inositol-1-phosphate + an N-acyl-sphingoid base + H(+) => an alpha-mannosylinositol-1-phosphoceramide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592233", "l": "p38 MAPK phosphorylates PPARGC1A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706399", "l": "RHOBTB3 hydrolyzes ATP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63128", "l": "H2O + N-docosanoyl-ethanolamine = docosanoate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32514", "l": "(4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O <=> (3R,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26331", "l": "(7R,8S)-7,8-diammoniononanoate + (S)-2-amino-6-oxohexanoate => (S)-8-amino-7-oxononanoate + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67144", "l": "2-oxoglutarate + jasmonate + O2 = (1R,2R)-12-hydroxyjasmonate + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204871", "l": "Interaction of Tie2 and Grb2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964280", "l": "Active Gq binds BTK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17857", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taurochenodeoxycholate = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taurohyocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63902", "l": "(2S)-2-(4-hydoxybenzyl)-3-(4-hydroxyphenyl)-2-furonol carboxylate + H2O => 2 3-(4-hydroxyphenyl)pyruvate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25297", "l": "acetaldehyde + H2O + NAD(+) <=> acetate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203774", "l": "Interaction of Csk with PAG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626988", "l": "TNF-alpha:TNFR1 binds NSMAF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50447", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2 <=> prostaglandin G3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65279", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 2alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44844", "l": "(R)-carnitine + eicosanoyl-CoA = CoA + O-eicosanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45704", "l": "(E)-sinapoyl alcohol + NADP(+) = (E)-sinapoaldehyde + H(+) + NADPH"}, {"i": "EC:1.1.1.195", "l": "\"Cinnamyl-alcohol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41042", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + dodecanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-dodecanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799332", "l": "ATR phosphorylates TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66212", "l": "asc-omegaC5-CoA + O2 = asc-omegaDeltaC5-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050575", "l": "2-(S)-hydroxypropyl-CoM dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848110", "l": "SOCS3 binds activated PTK6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25962", "l": "benzil + H(+) + NADPH => benzoin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19383", "l": "2-oxoglutarate + CO2 => (S)-oxalosuccinate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448963", "l": "Interaction of MyoD:E protein with MEF2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25202", "l": "D-ribulose 5-phosphate + formaldehyde => D-arabino-hex-3-ulose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37658", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944225", "l": "Association of procollagen type XVII (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38696", "l": "a cardiolipin(in) => a cardiolipin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59181", "l": "5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O => 2 AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008054", "l": "IL1F10 binds IL1RAPL1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36963", "l": "(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18521", "l": "licodione + S-adenosyl-L-methionine = 2'-O-methyllicodione + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.65", "l": "\"Licodione 2'-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102184", "l": "cycloartenol 4alpha-methyl oxidase activity"}, {"i": "MetaCyc:RXN-11946"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686578", "l": "Activated ATM phosphorylates ABL1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362427", "l": "Hh-Np binds GPC5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63201", "l": "(10bS,4aR)-noroxomaritidine + H(+) + NADPH => (10bS,4aR)-oxomaritidine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16867", "l": "3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA => choloyl-CoA + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19702", "l": "a flavonol 3-O-glycoside + UDP-alpha-D-xylose => a flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696822", "l": "AKR1B15 reduces EST17b to E1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0035613", "l": "RNA stem-loop binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4419986", "l": "Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47267", "l": "2,6,10,14-tetramethylpentadecanoate + ATP + CoA <=> AMP + diphosphate + pristanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2106625", "l": "Duplex siRNA is loaded into Argonaute (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48906", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP => L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28522", "l": "D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate"}, {"i": "EC:3.1.3.83", "l": "\"D-glycero-alpha-D-manno-heptose-1,7-bisphosphate 7-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071791", "l": "chemokine (C-C motif) ligand 5 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83793", "l": "Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668789", "l": "LA,TNFSF14 binds LTBR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35332", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) => (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54226", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphocholine => 2-(prostaglandin H2)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71164", "l": "homogentisate + O2 => maleylacetoacetate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66533", "l": "ATP + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] => diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28951", "l": "H(+)(in) + L-arabinose(in) = H(+)(out) + L-arabinose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.1.10", "l": "\"Magnesium dechelatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27516", "l": "phosphate + sphinganine => H2O + sphinganine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211983", "l": "CYP2J2 oxidises ARA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56458", "l": "12-epi-fischerindole U => 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55053", "l": "H2O + pentanoyl-CoA => CoA + H(+) + pentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29738", "l": "butane-1-sulfonate + FMNH2 + O2 <=> butanal + FMN + 2 H(+) + H2O + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48885", "l": "NADP(+) + protochlorophyllide a => 3,8-divinyl protochlorophyllide a + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24267", "l": "D-xylulose 5-phosphate + formaldehyde <=> D-glyceraldehyde 3-phosphate + dihydroxyacetone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956659", "l": "ABL1 phosphorylates YAP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419389", "l": "LPA-binding receptors bind LPA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57503", "l": "3-hydroxybutane-1,2,3-tricarboxylate <=> 2-methyl-cis-aconitate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33343", "l": "glycine + O2 = 2-iminoacetate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44448", "l": "an acyl-CoA + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22486", "l": "GMP + GTP + 2 H(+) => H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52692", "l": "3-phenyllactate + NADP(+) = 3-phenylpyruvate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66396", "l": "ATP + cholate(in) + glutathione(in) + H2O = ADP + cholate(out) + glutathione(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605717", "l": "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674022", "l": "BRAP autoubiquitinates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23049", "l": "(S)-3-hydroxybutanoate + 2-oxoglutarate => (R)-2-hydroxyglutarate + acetoacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53047", "l": "a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine <=> a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45606", "l": "5-dehydro-4-deoxy-D-glucarate + H(+) => D-glucaro-1,4-lactone"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047312", "l": "L-phenylalanine:pyruvate aminotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66462", "l": "14betaH-scalarane-17alpha-19-diol => (2E,6E,10E,14E)-geranylfarnesol + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080103", "l": "4-methylthiopropyl glucosinolate S-oxygenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0015424", "l": "ABC-type amino acid transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46583", "l": "O2 + reduced [NADPH--hemoprotein reductase] + vitamin D2 <=> 25-hydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61315", "l": "germacra-1(10),4,11(13)-trien-12-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> germacra-1(10),4,11(13)-trien-12-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694527", "l": "Loss of SAR1B GTPase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12092", "l": "(S)-acetoin = (R)-acetoin"}, {"i": "EC:5.1.2.4", "l": "\"Acetoin racemase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428918", "l": "Dissociation of the TP:G13 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804276", "l": "ATM phosphorylates TTC5 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2995334", "l": "COX15 transforms heme O to heme A (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265010", "l": "Cystine-bonded Proinsulin translocates from the endoplasmic reticulum to the Golgi (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16004", "l": "H(+) + H2O + N(6)-methyl-AMP <=> IMP + methylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67139", "l": "3-hydroxypropanoate + ATP + CoA <=> 3-hydroxypropanoyl-CoA + ADP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682709", "l": "LGI4 binds ADAM22,23,11 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983307", "l": "IL15 binds IL15RA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202724", "l": "P-selectin binds P-selectin ligand (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53975", "l": "(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418846", "l": "Caspase cleavage of UNC5A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050038", "l": "L-xylulose reductase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202394", "l": "Translocation of CARMA1 to Plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008427", "l": "calcium-dependent protein kinase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54757", "l": "deamido-NAD(+) + hydrogencarbonate => AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48652", "l": "lipoxin B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-lipoxin B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111264", "l": "Addition of nucleotides between position +11 and +30 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56282", "l": "AMP + L-prolyl-[peptidyl-carrier protein] => 3'-L-prolyl-AMP + holo-[peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56784", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate"}, {"i": "EC:3.4.19.9", "l": "\"Folate gamma-glutamyl hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30501", "l": "(E)-2-methylpropanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-valine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35891", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20608", "l": "cytosine + H(+) + H2O <=> NH4(+) + uracil"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662613", "l": "MT3 exchanges zinc for copper (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38650", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21226", "l": "CMP + H(+) + sphing-4-enine-phosphocholine => CDP-choline + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869560", "l": "The NOP2 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46840", "l": "4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33001", "l": "(+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => (+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61874", "l": "1-O-methyl-(9R)-hydroperoxy-(10E,12Z)-octadecadienoate => 1-O-methyl-(9Z,12Z)-octadecadienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49020", "l": "2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141367", "l": "Myristoylation of tBID by NMT1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51938", "l": "glutathione disulfide + hydroquinone => 2-(glutathione-S-yl)-hydroquinone + glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20631", "l": "L-seryl-[protein] + phosphate => H2O + O-phospho-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55965", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15675", "l": "acetoacetate + CoA + H(+) => acetoacetyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15832", "l": "a 16alpha-hydroxysteroid <=> a 16beta-hydroxysteroid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10261", "l": "ATP + H2O + Mg(2+)(out) => ADP + H(+) + Mg(2+)(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033509", "l": "USP9X binds Ub:PEX5L (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34996", "l": "L-rhamnose(in) => L-rhamnose(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102629", "l": "patuletin 3'-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-15534"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62608", "l": "glutathione + H(+) + hydrogen sulfide + ubiquinone-10 = S-sulfanylglutathione + ubiquinol-10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21866", "l": "a 2-hydroxy carboxylate + glutathione + H(+) => an S-(2-hydroxyacyl)glutathione + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5615668", "l": "AKR1C3 reduces atRAL to atROL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10585", "l": "4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH => 3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55594", "l": "(3R)-3-[(3R)-3-hydroxydecanoyloxy]decanoate + H(+) + 2 holo-[ACP] => 2 (3R)-hydroxydecanoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655323", "l": "Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189488", "l": "UROS transforms HMB to URO3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47645", "l": "adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451283", "l": "kainate receptor binds glutamate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638004", "l": "RP2 binds ARL3:GTP:UNC119B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814088", "l": "SYS1 binds AcM-ARFRP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710254", "l": "GSDME oligomerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25847", "l": "(1S,5R)-carveol + NAD(+) <=> (R)-carvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32106", "l": "2 S-adenosyl-L-methionine + trans-resveratrol <=> 2 H(+) + pterostilbene + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102365", "l": "taxusin 2-alpha-hydroxylase activity"}, {"i": "MetaCyc:RXN-13486"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983700", "l": "SYK binds the activated BCR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1912394", "l": "NICD1 in complex with RBPJ (CSL) recruits MAML (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52794", "l": "Mg(2+) + pheophorbide a => chlorophyllide a + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034880", "l": "citrazinate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632738", "l": "DDIT4 binds 14-3-3 dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12119", "l": "A + H2 <=> AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50316", "l": "ethyl octadecanoate + H2O = ethanol + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166869", "l": "TRAF6 binds MEKK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59096", "l": "monoglucosyl-enterobactin + UDP-alpha-D-glucose = diglucosyl-enterobactin + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26002", "l": "D-arabinitol 1-phosphate + NAD(+) = D-xylulose 5-phosphate + H(+) + NADH"}, {"i": "EC:1.1.1.301", "l": "\"D-arabitol-phosphate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866851", "l": "CFTR transits to the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8853496", "l": "SCF:FBXL7 binds AURKA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34105", "l": "N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061693", "l": "alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity"}, {"i": "RHEA:34679", "l": "ATP + methylphosphonate = adenine + alpha-D-ribose 1-methylphosphonate 5-triphosphate"}, {"i": "EC:2.7.8.37", "l": "\"Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32607", "l": "(6E)-8-hydroxygeraniol + NADP(+) = (6E)-8-hydroxygeranial + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24221", "l": "beta-myrcene + O2 + reduced [NADPH--hemoprotein reductase] => (4R)-ipsdienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427514", "l": "eNoSC deacetylates histone H3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13652", "l": "beta-D-glucose + NAD(+) <=> D-glucono-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686483", "l": "Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202222", "l": "Phosphorylation of PKC theta (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46194", "l": "3beta,7alpha-dihydroxyandrost-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34572", "l": "C30 botryococcene + diphosphate + NADP(+) => H(+) + NADPH + presqualene diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44540", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10019", "l": "H2O + O-sinapoylcholine <=> choline + E-sinapate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351948", "l": "Mitochondrial recruitment of Drp1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27287", "l": "(S)-acetoin + NAD(+) => diacetyl + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31624", "l": "L-olivosyl-oleandolide + S-adenosyl-L-methionine => H(+) + L-oleandrosyl-oleandolide + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41884", "l": "dodecanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417825", "l": "P2Y11 receptor can bind to ATP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40303", "l": "A + dodecanedioyl-CoA = (2E)-dodecenedioyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161666", "l": "PGA2 is isomerised to PGC2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38743", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-octadecenoyl)-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956659", "l": "ABL1 phosphorylates YAP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52458", "l": "H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP => testosterone + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23014", "l": "a fatty acid methyl ester + S-adenosyl-L-homocysteine => a fatty acid + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13113", "l": "2-acetamidofluorene + H2O + NADP(+) = H(+) + N-hydroxy-2-acetamidofluorene + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6791109", "l": "GADD45A binds PCNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198813", "l": "GSTO dimers reduce DeHA to AscH- (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27440", "l": "2 glutathione amide + H2O2 <=> glutathione amide disulfide + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612073", "l": "NGF- and MAPK-dependent EGR1, EGR2 and EGR4 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52634", "l": "[amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP => [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430308", "l": "PARVB interacts with Alpha-actinin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29901", "l": "ADP + D-xylose(in) + H(+) + phosphate => ATP + D-xylose(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37288", "l": "ATP + H2O + L-alanyl-L-leucine(out) => ADP + H(+) + L-alanyl-L-leucine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16707", "l": "estrone + H(+) + NADPH => 17alpha-estradiol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47158", "l": "7alpha,25-dihydroxy-4-cholesten-3-one + H(+) + NADH => 7alpha,25-dihydroxycholesterol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043770", "l": "demethylmenaquinone methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.20", "l": "\"Carboxypeptidase U\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61361", "l": "ATP + H2O + pheophorbide a(in) => ADP + H(+) + pheophorbide a(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75238", "l": "TRAIL binds TRAIL receptors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34184", "l": "alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose => alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635102", "l": "GPR161 is internalized (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.4", "l": "\"ABC-type teichoic-acid transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11590", "l": "AH2 + isoquinolin-1(2H)-one => A + H2O + isoquinoline"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035923", "l": "flurbiprofen binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5678327", "l": "MIOX oxidises Ins to GlcA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29620", "l": "alpha-maltotetraose + beta-maltose => alpha-maltopentaose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24060", "l": "N-hydroxy-L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27279", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) => 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201639", "l": "Caspase-mediated cleavage of GAS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55307", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate <=> 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17040", "l": "indole-3-ethanol + NADP(+) <=> H(+) + indole-3-acetaldehyde + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854466", "l": "VLDLR binds RELN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21895", "l": "D-arabinose + NADP(+) <=> D-arabinono-1,4-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202203", "l": "Recruitment of PI3K to plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37737", "l": "1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41953", "l": "2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate => [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50974", "l": "(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985201", "l": "ABCE1 binds RNASEL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1861788", "l": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404193", "l": "IGF1R phosphorylates SHC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46513", "l": "2 [Fe(II)-cytochrome b5] + an N-(1,2-saturated acyl)sphinganine + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + an N-[(2'R)-hydroxyacyl]sphinganine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388829", "l": "SHP2 phosphatase binds CTLA-4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709098", "l": "DHFR dimer reduces FOLA to DHF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19937", "l": "glycine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + sarcosine"}, {"i": "EC:2.1.1.20", "l": "\"Glycine N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849085", "l": "ARHGAP35 binds RHOA:GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32240", "l": "gamma-carotene => all-trans-beta-carotene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63514", "l": "biphenyl-2,2',3-triol + H2O + NAD(+) => biphenyl-2,2'-diol + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38267", "l": "2-methylfumaryl-CoA = 3-methylfumaryl-CoA"}, {"i": "EC:5.4.1.3", "l": "\"2-methylfumaryl-CoA isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74742", "l": "Phosphorylation of SHC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209156", "l": "MYD88 binds to TUB (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019535", "l": "ferric-vibriobactin transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34203", "l": "2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 = aureusidin 6-O-beta-glucoside + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952128", "l": "RUNX3 binds TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32305", "l": "(1R,2S)-homoisocitrate => (2R)-homocitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41824", "l": "3-oxohexanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyhexanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607744", "l": "MALT1 binds BCL10 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211191", "l": "Association of DFF with alpha:beta importin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27495", "l": "3'-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + tricetin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396393", "l": "NOTCH1 PEST domain mutants bind MYC promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66321", "l": "2',3'-cGAMP(out) => 2',3'-cGAMP(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9645220", "l": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72722", "l": "eIF2 activation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42525", "l": "uridine(1911/1915/1917) in 23S rRNA => pseudouridine(1911/1915/1917) in 23S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40691", "l": "1-hexadecanoylglycerone 3-phosphate + pentadecan-1-ol = 1-O-pentadecylglycerone 3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73729", "l": "Formation of SL1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607058", "l": "Activated protein C:PROCR binds F2R (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951499", "l": "Loading of antigenic peptides on to class I MHC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44139", "l": "dodecanoyl-CoA + hexadecan-1-ol <=> CoA + hexadecanyl dodecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090555", "l": "phosphatidylethanolamine flippase activity"}, {"i": "RHEA:66132", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47636", "l": "H2O + L-arginine + NADP(+) = 5-guanidino-2-oxopentanoate + H(+) + NADPH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602242", "l": "Defective CYP2U1 does not omega-hydroxylate ARA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65981", "l": "hnu + previtamin D3 => tachysterol 3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65538", "l": "H(+) + S-adenosyl-L-homocysteine + theacrine => 1,3,7-trimethylurate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004797", "l": "thymidine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-141437", "l": "Formation of the MCC complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004923", "l": "leukemia inhibitory factor receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675198", "l": "Activated MAPKs phosphorylate BRAF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62659", "l": "2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + dimethylallyl diphosphate <=> 2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38268", "l": "2-methylfumaryl-CoA => 3-methylfumaryl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41163", "l": "1-O-hexadecyl-2-amino-sn-glycerol + ATP = 1-O-hexadecyl-2-desoxy-2-amino-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54593", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + GTP + H(+) => a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26191", "l": "1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61930", "l": "(R)-miconazole(out) + ADP + H(+) + phosphate => (R)-miconazole(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417898", "l": "P2Y4 receptor can bind to UTP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876446", "l": "p-ULK1 phosphorylates DENND3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20955", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose <=> beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62262", "l": "2 hydrogencarbonate(in) + Mn(2+)(in) => 2 hydrogencarbonate(out) + Mn(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005519", "l": "cytoskeletal regulatory protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12120", "l": "alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate"}, {"i": "EC:2.7.7.27", "l": "\"Glucose-1-phosphate adenylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0042056", "l": "chemoattractant activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27926", "l": "UMP(in) = UMP(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42401", "l": "lactose(out) + N(pros)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + lactose 6-phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.13", "l": "\"Sucrose synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043712", "l": "2-hydroxyisocaproate CoA-transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43568", "l": "3,6-anhydro-alpha-L-galactopyranose + H2O + NAD(+) = 3,6-anhydro-L-galactonate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16398", "l": "2 D-glucopyranose 1-phosphate => D-glucose + D-glucose 1,6-bisphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39081", "l": "3-oxododecanedioyl-CoA + H(+) + NADH => (3S)-hydroxydodecanedioyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033410", "l": "UAC codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37754", "l": "2-methyl-trans-aconitate <=> 2-methyl-cis-aconitate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.83", "l": "\"Anthrax lethal factor endopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061652", "l": "FAT10 conjugating enzyme activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374664", "l": "Phosphorylation and activation of Ezrin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44505", "l": "4-hydroxybenzoate + an all-trans-polyprenyl diphosphate => a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332356", "l": "CAMK2 binds MAP3K7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400143", "l": "Fatty acid ligands activate PPARA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205321", "l": "Interaction of KIT and sSCF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13677", "l": "D-ribulose 5-phosphate = D-xylulose 5-phosphate"}, {"i": "EC:5.1.3.1", "l": "\"Ribulose-phosphate 3-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353472", "l": "Displacement of DNA glycosylase and endonucleolytic cleavage by DNA-lyase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-976768", "l": "Factor H binds to C3b (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25252", "l": "H(+) + 2 pyruvate <=> (2S)-2-acetolactate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5663050", "l": "DHI and DHICA polymerise forming eumelanin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010180", "l": "thioglucosidase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952749", "l": "STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50936", "l": "(3S)-3-aminobutanoyl-CoA + 2-oxoglutarate = acetoacetyl-CoA + L-glutamate"}, {"i": "EC:2.6.1.111", "l": "\"3-aminobutanoyl-CoA transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.6", "l": "\"Vesicle-fusing ATPase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624952", "l": "Assembly of the retrograde IFT train (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19988", "l": "NAD(+) + S-(hydroxymethyl)glutathione <=> H(+) + NADH + S-formylglutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12537", "l": "H(+) + L-arogenate => CO2 + H2O + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59632", "l": "D-xylobiose + O2 = D-xylobiono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11688", "l": "ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)"}, {"i": "EC:6.1.1.4", "l": "\"Leucine--tRNA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66623", "l": "5alpha-cholest-7-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> (25S)-Delta7-dafachronate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48542", "l": "dodecanoate + dodecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) => 1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63874", "l": "3(1)-hydroxy-L-isoleucine + CO2 + succinate => 2-oxoglutarate + L-isoleucine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862280", "l": "FCHo proteins bind nascent clathrin-coated pit (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48226", "l": "a neolactoside nLc4Cer(d18:1(4E)) + L-fucose => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57909", "l": "ATP + L-glutamyl-tRNA(Gln) => 5-phosphooxy-L-glutamyl-tRNA(Gln) + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66425", "l": "ATP + H2O + leukotriene B4(in) => ADP + H(+) + leukotriene B4(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909721", "l": "Translocation of ISGF3 complex to nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043185", "l": "vascular endothelial growth factor receptor 3 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474266", "l": "Formation of collagen fibrils (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47746", "l": "demethylphylloquinol + NADP(+) => demethylphylloquinone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031458", "l": "ABC-type betaine transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11050", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + 1-organyl-2-acetyl-sn-glycero-3-phospholipid => 1-organyl-2-lyso-sn-glycero-3-phospholipid + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42475", "l": "dibenzo-p-dioxin + NADH + O2 <=> 2,2',3-trihydroxydiphenyl ether + H(+) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54552", "l": "1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692749", "l": "CDC14A,B bind MAPK6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981728", "l": "Factor H binds to membrane-associated C3b (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37005", "l": "3-oxo-(13Z,16Z,19Z)-docosatrienoyl-CoA + CO2 + CoA => (11Z,14Z,17Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51133", "l": "a purine 2'-deoxyribonucleoside 5'-phosphate + H2O => 2-deoxy-D-ribose 5-phosphate + a purine nucleobase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42744", "l": "guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.174", "l": "\"23S rRNA (guanine(1835)-N(2))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48724", "l": "aurachin B + H(+) + H2O = 3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5671702", "l": "AP1G2 binds HGS and CHMP2A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57440", "l": "2-methylanisole + O2 + reduced [NADH--hemoprotein reductase] = 2-hydroxytoluene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18126", "l": "A + a D-alpha-amino acid + H2O => a 2-oxocarboxylate + AH2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11654", "l": "alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912790", "l": "CBL binds CRK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60212", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28623", "l": "(-)-vetispiradiene + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + solavetivol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210788", "l": "HNF1B- and FGF10-dependent synthesis of PTF1A protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12686", "l": "2 mycothiol + NADP(+) => H(+) + mycothione + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54205", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2 => 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420688", "l": "GABAB heterodimeric receptor binds GABA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13079", "l": "a carboxylate + D-hexose phosphate + H(+) => an acyl phosphate + D-hexose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42598", "l": "prostaglandin G2 => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912363", "l": "MIR200B/C microRNAs bind NOTCH1 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23544", "l": "a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-alpha-D-glucose = a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP"}, {"i": "EC:2.4.1.240", "l": "\"Flavonol-3-O-glycoside glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432054", "l": "Aquaporin-1 passively transports water out of cell (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58647", "l": "N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine <=> (9Z,12Z,15Z)-octadecatrienamide + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56068", "l": "an N-acetyl-alpha-D-glucosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64950", "l": "dCDP + H(+) + phosphate => dCTP + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0009041", "l": "uridylate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51089", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213241", "l": "Formation of nonameric complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9734713", "l": "ORC6 translocates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59802", "l": "CoA + H(+) + N(6)-decanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] => decanoyl-CoA + L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694344", "l": "Synthesis of SARS-CoV-2 minus strand subgenomic mRNAs by template switching (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46368", "l": "2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (9Z,11E,13E)-octadecatrienoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59681", "l": "D-maltopentaose + O2 => D-maltopentaono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12329", "l": "[(1->3)-alpha-D-glucosyl](n) + phosphate => [(1->3)-alpha-D-glucosyl](n-1) + beta-D-glucose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45807", "l": "ATP + hydroxylamine + L-glutamate <=> ADP + L-glutamine hydroxamate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649657", "l": "NEIL1 recognizes and binds FapyG-dsDNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29082", "l": "(R)-lactate + ubiquinone-8 <=> pyruvate + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376851", "l": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483186", "l": "PC is converted to PS by PTDSS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1980125", "l": "ITCH binds DTX (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27902", "l": "caffeine + H2O + ubiquinone-0 = 1,3,7-trimethylurate + ubiquinol-0"}, {"i": "RHEA:47148", "l": "a ubiquinone + caffeine + H2O = 1,3,7-trimethylurate + a ubiquinol"}, {"i": "EC:1.17.5.2", "l": "\"Caffeine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10037", "l": "4-hydroxy-3-methoxy-benzenemethanol + O2 => H2O2 + vanillin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58615", "l": "2 L-ascorbate + N-octanoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-octanoyl-(2S)-hydroxyglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64361", "l": "(3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 => (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62731", "l": "(+)-malbrancheamide B + bromide + FAD + 2 H(+) <=> (+)-malbrancheamide D + FADH2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005314", "l": "high-affinity glutamate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695831", "l": "FLT3 binds type II TKI (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-141341", "l": "SMOX-3 oxidises SPN to SPM (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617887", "l": "HOXC4 chromatin is activated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31759", "l": "dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine = dTDP-alpha-D-desosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.234", "l": "\"dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35348", "l": "3-hydroxyoctadecanoyl-CoA => (2E)-octadecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30948", "l": "(2E,6E)-farnesyl diphosphate + H2O => 10-epi-gamma-eudesmol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.29", "l": "\"Polyporopepsin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690196", "l": "USP8 deubiquitinates RNF128 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804762", "l": "TP53 forms homotetramers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28822", "l": "5-dehydro-D-gluconate(in) + H(+)(in) <=> 5-dehydro-D-gluconate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047819", "l": "D-glutamate(D-aspartate) oxidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106364", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity"}, {"i": "RHEA:20361", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381668", "l": "cAMP activates EPAC1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615910", "l": "SUMOylation of PCNA with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693347", "l": "HTR1A binds 5HT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218811", "l": "DOCK180:ELMO binds CRK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5655483", "l": "USP1 autocleavage (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381086", "l": "Dissociation of PERK:BiP Heterodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64292", "l": "3,8,9,10-tetrahydroxy-6-methyl-1,4-dihydroanthracen-1-one + H(+) + NADPH = (3R)-3,8,9,10-tetrahydroxy-6-methyl-1,2,3,4-tetrahydroanthracen-1-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090682", "l": "GPCR bitter taste receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875661", "l": "GGA3 associates with activated MET receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28694", "l": "(S)-dihydroorotate + a ubiquinone <=> a ubiquinol + orotate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36951", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + heptadecanoyl-CoA + O2 = (9Z)-heptadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607728", "l": "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986943", "l": "MECP2 binds MET gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626982", "l": "TNF-alpha:TNFR1:NSMAF binds GNB2L1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24312", "l": "L-lysyl-[cytochrome c] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.59", "l": "\"[Cytochrome c]-lysine N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63631", "l": "ATP + hexadecanoate + holo-[ACP] <=> AMP + diphosphate + hexadecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16458", "l": "(2R,3S)-tartrate + NAD(+) => 2-hydroxy-3-oxosuccinate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15069", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a = chlorophyllide a + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6813749", "l": "ALDH1A1 oxidises GA to DGA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6804099", "l": "HMGB1 binds LTP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44470", "l": "1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine => 3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953037", "l": "E2F8 forms homodimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685605", "l": "SLAMF7 binds SLAMF7 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709878", "l": "BIL translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140693", "l": "molecular condensate scaffold activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65047", "l": "4-cyanobenzyl alcohol + NAD(+) <=> 4-cyanobenzaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696605", "l": "USP12, USP26 deubiquitinate AR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730847", "l": "Hydrolysis of PIP2 by PLCG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11958", "l": "cholesterol + D-glucose => cholesteryl 3-beta-D-glucoside + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24230", "l": "4-methylcatechol + CO2 + NADH => (1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9632038", "l": "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683964", "l": "ATM phosphorylates EYA1-4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29974", "l": "2'-deoxyinosine(in) + H(+)(in) <=> 2'-deoxyinosine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37900", "l": "2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2 => 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46243", "l": "2 [Fe(II)-cytochrome b5] + a (9Z)-hexadecenoyl-containing glycerolipid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (9Z,12E)-hexadecadienoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50459", "l": "prostaglandin H3 <=> prostaglandin D3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940134", "l": "FOLR2 binds FOLA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418456", "l": "cGMP is degraded by PDEs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14983", "l": "androst-4-ene-3,17-dione + H(+) + NADPH => NADP(+) + testosterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23973", "l": "(2E)-glutaconyl-CoA + H(+) + Na(+)(in) => (2E)-butenoyl-CoA + CO2 + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0005375", "l": "copper ion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008929", "l": "methylglyoxal synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2321904", "l": "PTEN mRNA translation negatively regulated by microRNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34608", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-15-methylhexadecasphing-4-enine => a 1,2-diacyl-sn-glycerol + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725023", "l": "NPM-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55453", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => daturadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66253", "l": "ATP + CoA + IC-asc-C7 => AMP + diphosphate + IC-asc-C7-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990276", "l": "RNA 5'-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24226", "l": "4-methylcatechol + CO2 + NADPH => (1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57529", "l": "5'-end ribonucleotide-RNA + a ribonucleoside 5'-triphosphate + ATP + H2O => 5'-phospho-ribonucleosidyl-ribonucleotide-RNA + AMP + 2 diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2213207", "l": "Formation of collagen networks (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57254", "l": "glycolate + GTP + H(+) => H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57143", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16648", "l": "H2O + hexadecanoyl-CoA <=> CoA + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43428", "l": "1,2-didecanoyl-sn-glycerol + ATP = 1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33063", "l": "H(+) + NAD(+) + 2 reduced [2Fe-2S]-[putidaredoxin] = NADH + 2 oxidized [2Fe-2S]-[putidaredoxin]"}, {"i": "EC:1.18.1.5", "l": "\"Putidaredoxin--NAD(+) reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45075", "l": "(9Z)-octadecenoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] <=> (9Z)-18-hydroxyoctadecenoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41307", "l": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62147", "l": "dGMP + dGTP <=> 2 dGDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48764", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD(+) = 3-acetyl-3-devinylchlorophyllide a + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047305", "l": "(R)-3-amino-2-methylpropionate-pyruvate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20047", "l": "2 H(+) + malonate + NADH => 3-oxopropanoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043722", "l": "4-hydroxyphenylacetate decarboxylase activity"}, {"i": "RHEA:22732", "l": "4-hydroxyphenylacetate + H(+) = 4-methylphenol + CO2"}, {"i": "RHEA:62556", "l": "3,4-dihydroxyphenylacetate + H(+) = 4-methylcatechol + CO2"}, {"i": "EC:4.1.1.83", "l": "\"4-hydroxyphenylacetate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56952", "l": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174157", "l": "Degradation of multiubiquitinated Cyclin B (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26427", "l": "ATP + H2O + L-glutamine + UTP => ADP + CTP + 2 H(+) + L-glutamate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18983", "l": "2-dehydropantolactone + H(+) + NADPH => (R)-pantolactone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39583", "l": "(2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H(+) + NADPH = (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430135", "l": "p-SLP-76 binds ADAP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700175", "l": "Active ALK phosphorylates SHC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805507", "l": "APAF1 binds AVEN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64615", "l": "ATP + L-glutamate + tRNA(Gln) <=> AMP + diphosphate + L-glutamyl-tRNA(Gln)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033437", "l": "ACU codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708457", "l": "HM13 cleaves HMOX1 dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29337", "l": "L-alanine + L-glutamate => H2O + L-alanyl-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25694", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate"}, {"i": "EC:2.5.1.81", "l": "\"Geranylfarnesyl diphosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28063", "l": "alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5684140", "l": "ATM phosphorylates RBBP8 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614461", "l": "Tetramerization of procollagen VI (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25807", "l": "H2O + O2 + spermine <=> 3-aminopropanal + H2O2 + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46500", "l": "2-oxoglutarate + O2 + UMP = CO2 + phosphate + succinate + uridine-5'-aldehyde"}, {"i": "EC:1.14.11.49", "l": "\"Uridine-5'-phosphate dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35256", "l": "ATP + H2O + lipid A-core(in) => ADP + H(+) + lipid A-core(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28679", "l": "3-demethylubiquinol-8 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34706", "l": "(2E,6E)-farnesyl diphosphate <=> (E)-2-epi-beta-caryophyllene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56133", "l": "(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in DNA => a thymidine dimer in DNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450494", "l": "HuR binds mRNAs in the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63639", "l": "a medium-chain fatty acyl-AMP + holo-[ACP] <=> a medium-chain fatty acyl-[ACP] + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008158", "l": "hedgehog receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446694", "l": "IRAK4 phosphorylates IRAK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-688136", "l": "TNFAIP3 (A20) deubiquitinates RIP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59073", "l": "AH2 + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + A + cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33786", "l": "1(F)-beta-D-fructosylsucrose + sucrose <=> 1,6-kestotetraose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034002", "l": "(R)-limonene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61562", "l": "gibberellin A24 + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => gibberellin A15 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17923", "l": "D-xylulose + H(+) + NADH => D-arabinitol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445072", "l": "Interaction of PAK1 with Rac1-GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-888577", "l": "Synthesis of GABA by GAD2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399711", "l": "Activation of Ca impermeable AMPA receptors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140586", "l": "promoter-terminator loop anchoring activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050132", "l": "N-methylalanine dehydrogenase activity"}, {"i": "RHEA:21768", "l": "H2O + N-methyl-L-alanine + NADP(+) = H(+) + methylamine + NADPH + pyruvate"}, {"i": "EC:1.4.1.17", "l": "\"N-methylalanine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5638007", "l": "RP2 activates the GTPase activity of ARL3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3204318", "l": "cob(II)alamin binds to MTRR:MTR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202727", "l": "Integrin alphaMbeta2 (MAC1) binds JAM3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050483", "l": "IMP 5'-nucleotidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41977", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) => CMP + ganglioside GQ1b alpha (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9690494", "l": "RHOB translocates to the endosome membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400500", "l": "Synthesis of prepro-Glucose-dependent Insulinotropic Polypeptide (preproGIP) in intestinal K cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61227", "l": "H2O + L-asparagine + O2 <=> 2-oxosuccinamate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102137", "l": "7-oxateasterone synthase activity"}, {"i": "MetaCyc:RXN-11537"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196857", "l": "PANK2 phosphorylates PanK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229283", "l": "LCNs bind lipids (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60469", "l": "3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) => 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177942", "l": "EGFR binds EGF ligand (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52921", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate => 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15212", "l": "(2R,3R)-tartrate + NAD(+) <=> 2-hydroxy-3-oxosuccinate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419166", "l": "GEFs activate RhoA,B,C (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65606", "l": "CoA + H(+) + N-eicosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + eicosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.31", "l": "\"RBR-type E3 ubiquitin transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56701", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 => 3-[(Z)-2-isocyanoethenyl]-1H-indole + 2 CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247840", "l": "WLS binds WNT ligands in the Golgi (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51172", "l": "cytidine(62) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(62) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008774", "l": "acetaldehyde dehydrogenase (acetylating) activity"}, {"i": "RHEA:23288", "l": "acetaldehyde + CoA + NAD(+) = acetyl-CoA + H(+) + NADH"}, {"i": "EC:1.2.1.10", "l": "\"Acetaldehyde dehydrogenase (acetylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22004", "l": "ATP + L-seryl-[myosin light chain] = ADP + H(+) + O-phospho-L-seryl-[myosin light chain]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48419", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)) <=> CMP + ganglioside GM2 (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-532549", "l": "MPI isomerises Fru6P to Man6P (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-606349", "l": "Mis18 complex binds the centromere (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2399913", "l": "atRAL binds to RBP2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11230", "l": "(2S)-flavanone + H(+) + NADPH => (2S)-flavan-4-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5679205", "l": "ULK1 phosphorylates Beclin-1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619542", "l": "AMPK negatively regulates binding of MAPT to microtubules (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33276", "l": "a 1,2-diacyl-sn-glycerol + H2O => a 2-acylglycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0018835", "l": "carbon phosphorus lyase activity"}, {"i": "EC:4.7.1.-", "l": "\"Carbon-phosphorus lyases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63107", "l": "H(+) + ilicicolin A epoxide + NADPH + O2 <=> 16-hydroxy-ilicicolin A epoxide + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49626", "l": "ADP + D-erythritol 1-phosphate + H(+) => ATP + erythritol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55056", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.49", "l": "\"12-hydroxyjasmonoyl-L-amino acid 12-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848316", "l": "IL36 binds IL1RL2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59745", "l": "(9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] => CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33772", "l": "a 1,2-diacyl-sn-glycerol + CDP-N-methylethanolamine => 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60087", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+) <=> a 4alpha-methyl-3-oxosteroid + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65439", "l": "a 5'-end triphospho-adenylyl-adenylyl-cytidyl-adenosine in mRNA + GDP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidyl-adenosine in mRNA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017041", "l": "galactosylgalactosylglucosylceramidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76456", "l": "O-atom dealkylation of dextromethorphan (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44384", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + dodecanoyl-CoA = 1-heptadecanoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59542", "l": "butanoyl-CoA + CO2 => (2R)-ethylmalonyl-CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686930", "l": "RIPK3 is cleaved by CASP8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11815", "l": "H2O + methanethiol + O2 <=> formaldehyde + H(+) + H2O2 + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647994", "l": "RAS proteins are depalmitoylated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.14"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57726", "l": "CO2 + 2 Na(+)(out) + pyruvate => H(+) + 2 Na(+)(in) + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63484", "l": "2-oxoglutarate + L-prolyl-[protein] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23643", "l": "1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 <=> CO2 + ethene + 2 H2O + hydrogen cyanide + L-dehydroascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296043", "l": "Activation of HCN channels (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033441", "l": "AAU codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40353", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+) => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209381", "l": "AP-1 transcription factor, JRA:KAY, is phosphorylated by phosphorylated BSK kinase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211164", "l": "AKT phosphorylates FOXO1A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.7.8", "l": "\"Benzoyl-CoA reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983158", "l": "Trimming of peptides in ER (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941312", "l": "ZCCHC6, ZCCHC11 are mRNA uridyltransferases (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870703", "l": "SOD2 (MnSOD) gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27965", "l": "myo-inositol + pyrroloquinoline quinone <=> H(+) + pyrroloquinoline quinol + scyllo-inosose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.-", "l": "\"Other oxidoreductases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28950", "l": "H(+)(out) + L-arabinose(in) <=> H(+)(in) + L-arabinose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39627", "l": "(3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA = (2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17399", "l": "a 3-oxoacyl-[ACP] + H(+) + NADPH => a (3R)-hydroxyacyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55660", "l": "2 AH2 + all-trans-beta-carotene + 2 O2 = 2 A + echinenone + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003756", "l": "protein disulfide isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39598", "l": "(2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H(+) + NADPH <=> (10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51689", "l": "galactitol + NAD(+) => H(+) + keto-L-tagatose + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033965", "l": "aculeacin-A deacylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018639", "l": "xylene monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0099589", "l": "serotonin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791221", "l": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38206", "l": "19-hydroxyandrost-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-oxo-androst-4-ene-3,17-dione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46741", "l": "cholesta-5,7,24-trien-3beta-ol + H(+) + NADPH => cholesta-5,24-dien-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21456", "l": "(S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.19.68", "l": "\"(S)-canadine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18006", "l": "D-threitol + NADP(+) => D-erythrulose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "74.378130331796413", "identifiers": [{"i": "GO:0004721", "l": "phosphoprotein phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004358", "l": "glutamate N-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42678", "l": "H2O + L-alanin-3-yl L-histidin-5-yl sulfoxide => L-cysteine + L-histidine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60695", "l": "(E)-non-2-enal + H2O + NADP(+) <=> (E)-non-2-enoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27727", "l": "5-dehydro-4-deoxy-D-glucarate => 2-hydroxy-3-oxopropanoate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102379", "l": "steviolbioside glucosyltransferase activity (stevioside forming)"}, {"i": "MetaCyc:RXN-13514"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864595", "l": "TFAP2B homodimer binds YEATS4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49255", "l": "D-fructose(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-fructose 1-phosphate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670149", "l": "TERRA transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46282", "l": "2 [Fe(III)-cytochrome b5] + a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 H2O => 2 [Fe(II)-cytochrome b5] + an N-acylsphing-4-enine + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299318", "l": "Activation of TASK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018706", "l": "pyrogallol hydroxytransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70482", "l": "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2752115", "l": "SPP1 (osteopontin) binds CD44 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2396337", "l": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25460", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + sibirene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031896", "l": "V2 vasopressin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30789", "l": "(6R)-L-erythro-6,7-dihydrobiopterin + H2O + L-tyrosine => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694522", "l": "Inner coat assembly and cargo binding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64472", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + S-adenosyl-L-methionine = (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.373", "l": "\"2-hydroxy-4-(methylsulfanyl)butanoate S-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13851", "l": "D-ribulose => D-arabinose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50054", "l": "ADP + H(+) + phosphate + taurocholate(out) => ATP + H2O + taurocholate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49855", "l": "(3E)-octenoyl-CoA <=> (2E)-octenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427337", "l": "MBD2 binds methylcytosine in chromatin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090483", "l": "phosphatidylglycerol-phosphatidylethanolamine phosphatidyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13732", "l": "FAD <=> AMP + H(+) + riboflavin cyclic-4',5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0016759", "l": "cellulose synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27636", "l": "2,5-didehydro-D-gluconate + H(+) + NADPH => 5-dehydro-D-gluconate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619214", "l": "CaMKK binds activated calmodulin in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29950", "l": "H(+)(in) + L-rhamnopyranose(in) <=> H(+)(out) + L-rhamnopyranose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1299318", "l": "Activation of TASK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5651828", "l": "PARG dePARylates PARP1,PARP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097257", "l": "leukotriene B4 12-hydroxy dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73757", "l": "Binding of RRN3 to RNA Polymerase I (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174916", "l": "Formation of N-glucuronides (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.47", "l": "\"Alpha-santonin 1,2-reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212642", "l": "L-Glutamine transport into neurons (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944218", "l": "Association of procollagen type VIII (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102841", "l": "1-18:1-2-16:2-monogalactosyldiacylglycerol synthase activity"}, {"i": "MetaCyc:RXN-8302"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033806", "l": "fluorothreonine transaldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15935", "l": "(S)-lactaldehyde + H(+) + NADH => (S)-propane-1,2-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-182990", "l": "Sprouty sequesters CBL away from active EGFR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24643", "l": "ergosteryl 3-beta-D-glucoside + H2O <=> D-glucose + ergosterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9015111", "l": "Factor Xa inhibitors binds Xa (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59143", "l": "ATP + citrate + N(5)-[(S)-citryl]-D-ornithine <=> AMP + diphosphate + H(+) + staphyloferrin A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211874", "l": "CYP2S1 4-hydroxylates atRA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3781941", "l": "WNTs are secreted in exosomes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52675", "l": "2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate <=> [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42185", "l": "5alpha-androstane-3beta,17beta-diol + NAD(+) => 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110319", "l": "Elongation by POLH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46349", "l": "(2E)-octenoyl-CoA + H2O => 3-hydroxyoctanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865994", "l": "GAB1 binds PTPN11 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418200", "l": "SRC-1 bound to ARRB2 is not activated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8934446", "l": "Activated PKC phosphorylates SHC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39097", "l": "3-oxodecanedioyl-CoA + H(+) + NADH => (3S)-hydroxydecanedioyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191402", "l": "Reduction of presqualene diphosphate to form squalene (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55577", "l": "4-hydroxy-N-methyltryptamine 4-phosphate + S-adenosyl-L-methionine => H(+) + psilocybin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36087", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5444516", "l": "Formation of MSH2:MSH6 Complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790041", "l": "Expression of STAT3-upregulated cytosolic proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20944", "l": "S-adenosyl-L-methionine + theobromine = caffeine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814671", "l": "Fusion of late-endosome derived vesicles at the TGN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170964", "l": "FRS2 binds to active TrkA receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799441", "l": "TP53 stimulates expression of the TP53I3 (PIG3) gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.48"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26417", "l": "a secondary aliphatic amine + H2O + O2 <=> a primary amine + an aldehyde + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55125", "l": "(2E)-5-methylhexenoyl-[ACP] + H(+) + NADH => 5-methylhexanoyl-[ACP] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40635", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004980", "l": "melanocyte-stimulating hormone receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696183", "l": "AOC3 deaminates BZAM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21352", "l": "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+)"}, {"i": "EC:1.13.11.25", "l": "\"3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41440", "l": "(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 = (1R)-(2-amino-1-hydroxyethyl)phosphonate + CO2 + succinate"}, {"i": "EC:1.14.11.46", "l": "\"2-aminoethylphosphonate dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27917", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O <=> 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31166", "l": "(3S)-hydroxyhexadecanoyl-CoA <=> (2E)-hexadecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663736", "l": "CHRNA9:CHRNA10 binds acetylcholine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26235", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + plaunotol => (2E,6E,10E)-geranylgeraniol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374662", "l": "Translocation of Ezrin to plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38315", "l": "chorismate = 3-hydroxybenzoate + pyruvate"}, {"i": "EC:4.1.3.45", "l": "\"3-hydroxybenzoate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52552", "l": "3-dehydro-L-erythronate + ATP = 3-dehydro-4-O-phospho-L-erythronate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034211", "l": "GTP-dependent protein kinase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018683", "l": "camphor 5-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803403", "l": "PCBP4 binds the CDKN1A mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018624", "l": "toluene dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159826", "l": "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21383", "l": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA <=> AMP + diphosphate + phytanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161282", "l": "Elastic fibres bind associated proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28363", "l": "dGTP + H2O => dGMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005170", "l": "neurotrophin TRKC receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43435", "l": "2 [Fe(III)cytochrome c] + butan-1-ol <=> 2 [Fe(II)cytochrome c] + butanal + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29565", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate => ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686430", "l": "MUS81 binds EME1, EME2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65869", "l": "Delta(1)-dihydrotestosterone + H2O => 1,17beta-dihydroxyandrostan-3-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24850", "l": "3,4-dihydroxybenzoate + H2O => 3-dehydroshikimate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48051", "l": "ganglioside GM1 (d18:1(4E)) + H2O <=> D-galactose + ganglioside GM2 (d18:1(4E))"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007640", "l": "RBBP4 gene expression is inhibited by E2F6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5195402", "l": "CDK1 phosphorylates LPIN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354087", "l": "Recruitment of GRB2 to p-PTK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57877", "l": "uridine(54) in tRNA => pseudouridine(54) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.29", "l": "\"Sphingolipid 8-(E/Z)-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879459", "l": "F-actin capping protein is a heterodimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12222", "l": "4-methyl-2-oxopentanoate + H(+) + NADH + NH4(+) => H2O + L-leucine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62038", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+) => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60565", "l": "2-deoxy-D-glucose + ATP => 2-deoxy-D-glucose 6-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005391", "l": "P-type sodium:potassium-exchanging transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27323", "l": "6-deoxotyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-epi-6-deoxocathasterone + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247847", "l": "WLS is endocytosed to the early endosome (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.10", "l": "\"Tripeptidyl-peptidase II\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1067659", "l": "Assembly of hexameric IL-6 receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9032751", "l": "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33716", "l": "4-hydroxyeicosasphinganine 1-phosphate => 2-hydroxyoctadecanal + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19368", "l": "ATP + D-ribulose 5-phosphate <=> ADP + D-ribulose 1,5-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15059", "l": "(9Z)-octadecenoate + H(+) + holo-[ACP] => (9Z)-octadecenoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004507", "l": "steroid 11-beta-monooxygenase activity"}, {"i": "REACT:R-HSA-193997", "l": "CYP11B1 oxidises 11DCORT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694436", "l": "MIA2 and MIA3 dissociate from procollagen VII vesicle (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15684", "l": "2-hydroxy-5-carboxymethylmuconate semialdehyde + H2O + NAD(+) <=> (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050571", "l": "1,5-anhydro-D-fructose reductase activity"}, {"i": "RHEA:20665", "l": "1,5-anhydro-D-glucitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH"}, {"i": "EC:1.1.1.263", "l": "\"1,5-anhydro-D-fructose reductase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047330", "l": "polyphosphate-glucose phosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36984", "l": "(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18946", "l": "2-oxoglutarate + L-prolyl-[collagen] + O2 => CO2 + succinate + trans-4-hydroxy-L-prolyl-[collagen]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805399", "l": "TAF1 phosphorylates TP53 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40149", "l": "CoA + eicosanoate + H(+) => eicosanoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445087", "l": "CHL1 interacts with HSP7C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204549", "l": "Caveolin-1 binds Basigin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65574", "l": "(-)-4'-desmethyl-deoxypodophyllotoxin + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55418", "l": "biochanin A 7-O-beta-D-glucoside + H(+) + UDP => biochanin A + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56936", "l": "17beta-hydroxy-androst-5-en-3-one = testosterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653957", "l": "Rag dimer formation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58670", "l": "3-deoxyglucosone + H(+) + NADPH => 3-deoxyfructose + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37391", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z)-octadecaenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2545196", "l": "FN1 dimerizes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51982", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + H2O => an L-N,N-dihydroxypolyhomomethionine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39323", "l": "(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186798", "l": "GAP binds to PDGF-beta receptors only (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51713", "l": "keto-D-tagatose 6-phosphate => keto-D-fructose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047744", "l": "chloridazon-catechol dioxygenase activity"}, {"i": "RHEA:20449", "l": "5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2 = 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+)"}, {"i": "EC:1.13.11.36", "l": "\"Chloridazon-catechol dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693761", "l": "FA2H hydroxylates CERA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28071", "l": "(2E,6E)-farnesyl diphosphate + H2O + heme b => diphosphate + Fe(II)-heme o"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38968", "l": "an N-acylsphing-4-enine(in) + ATP + H2O => ADP + an N-acylsphing-4-enine(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381668", "l": "cAMP activates EPAC1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51785", "l": "4-prenylphlorisovalerophenone + dimethylallyl diphosphate => deoxyhumulone + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800794", "l": "PIDD1 associates with CRADD (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9626816", "l": "PIN1 binds p-S345-NCF1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37057", "l": "3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate => 3-(4-hydroxyphenyl)pyruvate + dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004971", "l": "AMPA glutamate receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44977", "l": "(R)-carnitine + propanoyl-CoA => CoA + O-propanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180606", "l": "Association of Vpu with CD4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19320", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate <=> 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53804", "l": "allodeoxycholoyl-CoA + ursodeoxycholate = allodeoxycholate + ursodeoxycholoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170799", "l": "cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59165", "l": "ATP + hexadecanoate + holo-[(hydroxy)phthioceranic acid synthase] => AMP + diphosphate + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050071", "l": "lysyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2317314", "l": "AKT binds PDPK1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804383", "l": "PRMT5 methylates TP53 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465924", "l": "OPN1LW binds 11cRAL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37322", "l": "ATP + glycyl-L-methionine(out) + H2O <=> ADP + glycyl-L-methionine(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016767", "l": "geranylgeranyl-diphosphate geranylgeranyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623059", "l": "FOXO1 binds POMC gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60391", "l": "Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O <=> Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "72.610931868743009", "identifiers": [{"i": "GO:0016790", "l": "thiolester hydrolase activity"}, {"i": "EC:3.1.2.-", "l": "\"Thiolester hydrolases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14300", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O <=> an N-acylsphing-4-enine + D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111930", "l": "Adenylate cyclase produces cAMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031691", "l": "alpha-1A adrenergic receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672948", "l": "MARK3 phosphorylates KSR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797100", "l": "CCNK binds CDK13 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63054", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + methanol => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54025", "l": "2-oxoglutarate + L-histidyl-[ribosomal protein uL15] + O2 => (3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66803", "l": "miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + miltiradien-20-al + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33892", "l": "chanoclavine-I + NAD(+) => chanoclavine-I aldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55554", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63204", "l": "H2O + octadecanoyl-[ACP] = H(+) + holo-[ACP] + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804879", "l": "MDM2 ubiquitinates TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23726", "l": "4-pyridoxate + H(+) + H2O2 => H2O + O2 + pyridoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49340", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin = 2-hydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38895", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41766", "l": "CMP + ganglioside GT3 (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD3 (d18:1(4E))"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62591", "l": "2-hydroxy-2-(4-hydroxyphenyl)acetate + H(+) <=> 4-hydroxybenzyl alcohol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350450", "l": "RHO1:GTP complex dissociates from RHOGEF2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607002", "l": "Activated protein C cleaves factor VIIIa (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14286", "l": "sn-glycerol 3-phosphate + UDP-alpha-D-galactose => 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10392", "l": "(E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033434", "l": "AUC codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664285", "l": "IgG binds the surface of the amastigote form of Leishmania (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60267", "l": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59064", "l": "demethylluteothin + S-adenosyl-L-methionine = luteothin + S-adenosyl-L-homocysteine"}, {"i": "RHEA:59068", "l": "demethyldeoxyspectinabilin + S-adenosyl-L-methionine = deoxyspectinabilin + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.353", "l": "\"Demethylluteothin O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9612219", "l": "ERBB4s80 binds to SRC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933533", "l": "Dimerization of p-IRF7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374909", "l": "Metabolism of Noradrenaline (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807144", "l": "HTN1,HTN3 or HTN5 binds the bacterial anionic surface  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61882", "l": "1-O-methyl-12-hydroperoxy-20-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => 1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417927", "l": "P2Y2 receptor binds ATP and UTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31965", "l": "9beta-pimara-7,15-dien-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-al + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61667", "l": "(2E,6E,10E)-geranylgeraniol + ATP <=> (2E,6E,10E)-geranylgeranyl phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43320", "l": "1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin = a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697838", "l": "ATP7A transfers Cu from ATOX1 to SOD3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9007901", "l": "IL1F10 binds IL1RL2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102195", "l": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase activity"}, {"i": "MetaCyc:RXN-12042"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047722", "l": "indolelactate dehydrogenase (NADH) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199839", "l": "AKT can phosphorylate RSK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983700", "l": "SYK binds the activated BCR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57264", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP = GDP + glycolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.24", "l": "\"Rhamnogalacturonan exolyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852331", "l": "GTSE1 translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40889", "l": "H(+) + octadecanoate + sn-glycerol 3-phosphocholine => 1-octadecanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13211", "l": "AH2 + 4 H(+) + 3 sulfite => A + 3 H2O + trithionate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55337", "l": "a 5'-hydroxy-3'-methoxyflavone + S-adenosyl-L-methionine => a 3',5'-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38300", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA => 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031762", "l": "follicle-stimulating hormone receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205136", "l": "GTP-bound RAC contributes to JNK activation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32540", "l": "(2E)-geranyl diphosphate => (+)-car-3-ene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74723", "l": "Endosome acidification (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482770", "l": "Release of platelet secretory granule components (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44108", "l": "H2O + heptanal + NAD(+) = 2 H(+) + heptanoate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31291", "l": "(S)-malate + FAD + H(+) = FADH2 + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139909", "l": "Translocation of BMF to mitochondria (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614790", "l": "EGR2, SOX10 and SMARCA4 bind the MPZ gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10210", "l": "H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg) => an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357445", "l": "PAK1-3 dimer disassociates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9650165", "l": "ASIC trimers bind H+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61557", "l": "gibberellin A12 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => gibberellin A15 + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712183", "l": "ADCY3:GNAL:GTP converts ATP to cAMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358790", "l": "RNF41 ubiquitinates ERBB3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13667", "l": "3',5'-cyclic GMP + diphosphate => GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16860", "l": "a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine <=> an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034565", "l": "1-nitro-1,2-dihydro-1,3,5-triazine hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33057", "l": "diphosphate + GTP + H(+) => guanosine 3'-diphosphate 5'-triphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676595", "l": "TRAFs bind RANK:RANKL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57428", "l": "anisole + O2 + reduced [NADH--hemoprotein reductase] = formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] + phenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36854", "l": "(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39477", "l": "(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H2O => (3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005412", "l": "glucose:sodium symporter activity"}, {"i": "REACT:R-HSA-5658163", "l": "Defective SLC5A2 does not cotransport Glc and Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53454", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + a cholesterol ester => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + cholesterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862771", "l": "PLA2G2A binds bacterial phospholipids (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49718", "l": "3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + H2O + NAD(+) => 3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18215", "l": "CDP-D-glucose + diphosphate => alpha-D-glucose 1-phosphate + CTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62059", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose <=> alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982765", "l": "Growth hormone forms dimers and oligomers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174741", "l": "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15536", "l": "(R)-3-sulfolactate + NAD(+) <=> 3-sulfopyruvate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879594", "l": "SLCO4C1 mediates the transport of digoxin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.4.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4332363", "l": "Autophosphorylation and activation of CAMK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41338", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798748", "l": "Exocytosis of secretory granule lumen proteins (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21425", "l": "3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+) => 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20926", "l": "a [peptide]-C-terminal amide + glyoxylate => a [peptide]-C-terminal (2S)-2-hydroxyglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40185", "l": "(2E)-tetradecenoyl-CoA + H2O2 => O2 + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368140", "l": "Expression of PPARGC1A (PGC-1alpha) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44935", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18686", "l": "H(+) + NADPH + O2 + pentachlorophenol => 2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9677579", "l": "CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40955", "l": "(R)-5-phosphomevalonate + ATP = ADP + CO2 + isopentenyl phosphate + phosphate"}, {"i": "EC:4.1.1.99", "l": "\"Phosphomevalonate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.24", "l": "\"Malyl-CoA lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23026", "l": "[(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate => [(1->4)-beta-D-glucosyl](n) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52457", "l": "testosterone + UDP-alpha-D-glucuronate => H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870469", "l": "RGGT geranylgeranylates RAB proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49353", "l": "2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2'-hydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54052", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + tau-cadinol"}, {"i": "EC:4.2.3.173", "l": "\"Tau-cadinol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58482", "l": "ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate => a cytidine in mRNA + acetyl-CoA + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.19", "l": "\"C-19 steroid 1-alpha-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11374", "l": "AMP + diphosphate + H(+) + L-asparagine => ATP + L-aspartate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66422", "l": "ADP + glutathione(out) + H(+) + phosphate + tauroursodeoxycholate(out) => ATP + glutathione(in) + H2O + tauroursodeoxycholate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-381109", "l": "IRE1 binds IRE1 forming dimer (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605591", "l": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15089", "l": "(R)-lactate + A = AH2 + pyruvate"}, {"i": "EC:1.1.99.6", "l": "\"D-lactate dehydrogenase (acceptor)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47290", "l": "7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.150"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24929", "l": "NH4(+) + pyruvate + S-sulfanyl-L-cysteine => H2O + L-cystine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18753", "l": "[protein]-dithiol + NADP(+) = [protein]-disulfide + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707586", "l": "FeHM oxidises LDL,HDL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3321883", "l": "MSL acetylates histone H4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48890", "l": "(13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203613", "l": "depalmitoylation of eNOS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102398", "l": "dTDP-3-amino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N-methyltransferase activity"}, {"i": "MetaCyc:RXN-13657"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28228", "l": "capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001872", "l": "(1->3)-beta-D-glucan binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62645", "l": "(5Z,8Z)-eicosadienoate + O2 => (5S)-hydroperoxy-(6E,8Z)-eicosadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20435", "l": "D-xylulose + H(+) + NADH => NAD(+) + xylitol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59515", "l": "acetylsalicylate + L-seryl-[protein] <=> O-acetyl-L-seryl-[protein] + salicylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54218", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O => 2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15324", "l": "(6aR,11aR)-3,9-dihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] <=> (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15796", "l": "bilirubin IXalpha + NADP(+) <=> biliverdin IXalpha + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25557", "l": "9alpha-copalyl diphosphate => diphosphate + stemod-13(17)-ene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114352", "l": "Sequestration of tBID by BCL-2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610726", "l": "The IFT-A complex recruits TULP3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25635", "l": "H(+) + S-adenosyl-L-homocysteine + syringetin => laricitrin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36224", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + H(+) + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75850", "l": "Addition of the third nucleotide on the nascent transcript (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66083", "l": "2-oxopentanoate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminopentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12319", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60851", "l": "a 5'-end diphospho-guanosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] <=> a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676589", "l": "RANKL,sRANKL trimer binds RANK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59971", "l": "L-threonyl-[protein] + octanoyl-CoA <=> CoA + O-octanoyl-L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712085", "l": "ALK mutants phosphorylate STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5444511", "l": "Formation of MSH2:MSH3 Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39973", "l": "2-aminobut-2-enoate => 1-aminocyclopropane-1-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.17", "l": "\"Adenosine-phosphate deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46784", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(9Z,12Z,15Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10438", "l": "12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O => 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928644", "l": "EPHB binds ITSN1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51124", "l": "uridine in snRNA = pseudouridine in snRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684017", "l": "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183126", "l": "Factor B binds to surface-associated C3b (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047035", "l": "testosterone dehydrogenase (NAD+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20765", "l": "(S)-methylmalonyl-CoA + pyruvate => oxaloacetate + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58697", "l": "NADPH + O2 + rifampicin => H(+) + H2O + NADP(+) + rifampicin para-naphthoquinone carboxamide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904091", "l": "peptidyl carrier protein activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868236", "l": "BAR domain proteins recruit dynamin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11197", "l": "5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide => alpha-ribazole 5'-phosphate + H(+) + nicotinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199456", "l": "PTEN dephosphorylates PIP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59660", "l": "D-cellotetraose + O2 = D-cellotetraono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451506", "l": "TLR21homodimer binds to DNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22270", "l": "ADP + H(+) + streptomycin 6-phosphate => ATP + streptomycin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211247", "l": "Cleavage of DNA by DFF40 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008564", "l": "protein-exporting ATPase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38033", "l": "(2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate + CO2 => (3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0019902", "l": "phosphatase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195275", "l": "Phosphorylation of APC component of the destruction complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043881", "l": "mesaconyl-CoA hydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636247", "l": "PPE2:KPNA1:KPNB1 translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19874", "l": "3beta-sulfooxy-androst-5-en-17-one + H2O => 3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004162", "l": "dimethylnitrosamine demethylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24327", "l": "6-oxocineole + H(+) + NADPH + O2 <=> 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "80.661393760018115", "identifiers": [{"i": "GO:0016273", "l": "arginine N-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9658253", "l": "RAS:GTP binds PI3K (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73806", "l": "AIR + CO2 => CAIR (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13820", "l": "[protein]-disulfide + H2O + phylloquinone <=> 2,3-epoxyphylloquinone + [protein]-dithiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46020", "l": "[pyruvate, water dikinase] + ADP = [pyruvate, water dikinase]-phosphate + AMP + H(+)"}, {"i": "EC:2.7.11.33", "l": "\"[Pyruvate, water dikinase] kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58446", "l": "H(+) + N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine => N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64295", "l": "3,8,9,10-tetrahydroxy-6-methyl-1,4-dihydroanthracen-1-one + H(+) + NADPH <=> (3R)-3,8,9,10-tetrahydroxy-6-methyl-1,2,3,4-tetrahydroanthracen-1-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48648", "l": "lipoxin A4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-lipoxin A4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17523", "l": "ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate => ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30389", "l": "alpha-D-glucose 1-phosphate + GDP + H(+) => GDP-alpha-D-glucose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9734713", "l": "ORC6 translocates to the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46603", "l": "[HPr protein]-L-serine + ATP <=> [HPr protein]-O-phospho-L-serine + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607751", "l": "TRAF6 oligomerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9640167", "l": "RRAGA,B exchanges GDP for GTP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209135", "l": "GISH further phosphorylates ARR in the receptor complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41103", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22161", "l": "4-coumaroyl-CoA + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside => a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41481", "l": "an acyl-CoA + episterol => an episterol ester + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25391", "l": "(3Z)-6-oxohex-3-enoyl-CoA + H2O + NADP(+) = cis-3,4-dehydroadipyl-CoA + 2 H(+) + NADPH"}, {"i": "EC:1.2.1.77", "l": "\"3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429157", "l": "ABCC4 accumulation of dense granule contents (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8873923", "l": "STARD10 binds LPCAT1 and PC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53987", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266350", "l": "CETP-mediated lipid exchange: LDL gains cholesterol ester (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865454", "l": "CBFB binds RUNX3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000074", "l": "TCII binds Cbl in the circulation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001058", "l": "RNA polymerase V activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429101", "l": "HMIT co-transports myo-inositol with a proton (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664332", "l": "CREB1 binds IL-10 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8856808", "l": "Recruitment of AP-2 complex and clathrin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11803", "l": "H2O + NAD(+) <=> AMP + beta-nicotinamide D-ribonucleotide + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444523", "l": "CXCR5 binds CXCL13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32981", "l": "a fatty acid + H(+) + sn-glycero-3-phospho-L-serine => a 1-acyl-sn-glycero-3-phospho-L-serine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59678", "l": "D-maltotetraono-1,5-lactone + H2O2 => D-maltotetraose + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084990", "l": "Nuclear CMP-Neu5Ac translocates to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.15"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088299", "l": "FOXM1 stimulates CCNB2 transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53179", "l": "H2O + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63174", "l": "(25R)-3-oxocholest-4-en-26-oyl-CoA => (25S)-3-oxocholest-4-en-26-oyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209566", "l": "TRAF6 is auto-ubiquitinated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49607", "l": "2-glutathionyl-2-methylbut-3-en-1-ol + NAD(+) <=> 2-glutathionyl-2-methylbut-3-enal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17611", "l": "3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + H(+) + L-methionine => L-seryl-[sulfatase] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5615668", "l": "AKR1C3 reduces atRAL to atROL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028598", "l": "Phosphorylation of YAP by LATS1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8963851", "l": "VD3 dissociates from GC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50413", "l": "L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein] => H(+) + N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042957", "l": "dextrin transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30148", "l": "FADH2 + NAD(+) => FAD + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46156", "l": "15,9'-di-cis-phytofluene + a plastoquinone = 9,9',15-tri-cis-zeta-carotene + a plastoquinol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090722", "l": "receptor-receptor interaction"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210780", "l": "PDX1-dependent synthesis of NKX6-1 protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047090", "l": "benzoyl-CoA 3-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30243", "l": "4 L-ascorbate + O2 = 2 H2O + 4 monodehydro-L-ascorbate radical"}, {"i": "EC:1.10.3.3", "l": "\"L-ascorbate oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865275", "l": "PDGF-BB clevage by Furin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38953", "l": "ADP + H(+) + phosphate + sphing-4-enine 1-phosphate(out) => ATP + H2O + sphing-4-enine 1-phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14624", "l": "(S)-2,3-epoxysqualene <=> lanosterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24879", "l": "A + L-sorbopyranose => 1-dehydro-L-sorbose + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865774", "l": "TTLLs polyglutamylate tubulin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58889", "l": "4-aminobenzoate + AH2 + 2 O2 => 4-nitrobenzoate + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41608", "l": "3'-phosphoadenylyl sulfate + alpha,alpha-trehalose = 2-O-sulfo-alpha,alpha-trehalose + adenosine 3',5'-bisphosphate + H(+)"}, {"i": "EC:2.8.2.37", "l": "\"Trehalose 2-sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43879", "l": "3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oate + ATP + CoA <=> 3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16580", "l": "ADP + ATP + H(+) <=> P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684140", "l": "ATM phosphorylates RBBP8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12533", "l": "coenzyme B + methyl-coenzyme M => coenzyme M-coenzyme B heterodisulfide + methane"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212222", "l": "PRC2 recruits DNA methyltransferases (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58465", "l": "a neolactoside nLc4Cer + UDP-N-acetyl-alpha-D-glucosamine => a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034016", "l": "polyenoic fatty acid isomerase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047691", "l": "aspulvinone dimethylallyltransferase activity"}, {"i": "MetaCyc:ASPULVINONE-DIMETHYLALLYLTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11345", "l": "an N-acylneuraminate + CTP => a CMP-N-acyl-beta-neuraminate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9011748", "l": "IL9R binds JAK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3785711", "l": "Telomere shortening during replicative exhaustion (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046702", "l": "galactoside 6-L-fucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174255", "l": "Degradation multiubiquitinated Cyclin A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12516", "l": "(2E,6E)-farnesyl diphosphate = (+)-(R)-germacrene A + diphosphate"}, {"i": "EC:4.2.3.23", "l": "\"Germacrene-A synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654511", "l": "FGFRL1 dimer binds FGFs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21454", "l": "a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical => a [peptide]-C-terminal glycine + 2 L-ascorbate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442387", "l": "ZIP8 mediates zinc influx into cells (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16234", "l": "(R)-pantoate + NADP(+) => 2-dehydropantoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-438005", "l": "MKK4 phosphorylates JNK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798082", "l": "TP53 family members bind the CASP1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018471", "l": "4-chlorobenzaldehyde oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11355", "l": "acetate + ATP <=> acetyl phosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32272", "l": "(2R,3S)-3-isopropylmalate + NAD(+) => 4-methyl-2-oxopentanoate + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5339535", "l": "GLTPD1 transports C1P from plasma membrane to Golgi membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50178", "l": "N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma-aminobutanoate => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169394", "l": "ISGylation of IRF3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38761", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450488", "l": "BRF1 Complex recruits RNA degradation activities (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183052", "l": "CBL binds to GRB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190256", "l": "FGFR1c binds to FGF (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70475", "l": "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19157", "l": "D-xylonate = 2-dehydro-3-deoxy-D-arabinonate + H2O"}, {"i": "EC:4.2.1.82", "l": "\"Xylonate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111879", "l": "PIP2 hydrolysis (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664278", "l": "Phosphorylation and activation of PLCG due to FCGR3A effect (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47790", "l": "a 5-methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in 28S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483186", "l": "PC is converted to PS by PTDSS1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42718", "l": "(2E)-thiogeraniol + 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate => (2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65759", "l": "2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] <=> (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.9", "l": "\"Phosphomannan mannosephosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9658253", "l": "RAS:GTP binds PI3K (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193669", "l": "TRAF6 binds to p75NTR:NRIF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37513", "l": "1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62218", "l": "H(+) + NADPH + phyllostine => isoepoxydon + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928657", "l": "MMP2,9 cleave EPHB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42433", "l": "3-hydroxy-cis,cis-muconate => maleylacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49167", "l": "a bacteriochlorophyllide c + H2O + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide c + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848726", "l": "PTK6 phosphorylates BCAR1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43443", "l": "hexadecanoate + sphinganine <=> H2O + N-hexadecanoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9608048", "l": "Expression of PLIN1 regulated by NR1H2 or NR1H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9677579", "l": "CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205132", "l": "NRAGE activates JNK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19247", "l": "2-aminophenol => N-phenylhydroxylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725009", "l": "NPM-ALK translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "69.997272734060871", "identifiers": [{"i": "GO:0016799", "l": "hydrolase activity, hydrolyzing N-glycosyl compounds"}, {"i": "EC:3.2.2.-", "l": "\"Hydrolyzing N-glycosyl compounds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64552", "l": "(3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + O2 + reduced [NADPH--hemoprotein reductase] = 3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32183", "l": "cholesterol + O2 = cholest-5-en-3-one + H2O2"}, {"i": "EC:1.1.3.6", "l": "\"Cholesterol oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9637641", "l": "Rv2779c binds TLR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30021", "l": "ADP + H(+) + lipid A-core => ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66494", "l": "alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-galctosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => GDP-alpha-D-mannose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28831", "l": "D-gluconate(in) + H(+)(in) = D-gluconate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9612501", "l": "SGK phosphorylates CREB1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36904", "l": "7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine => 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15022", "l": "(E)-feruloyl-CoA + L-quinate => 4-O-feruloyl-D-quinate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046811", "l": "histone deacetylase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65915", "l": "3-hydroxy-L-kynurenine + pyruvate <=> 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16020", "l": "2-oxoglutarate + L-ornithine <=> 5-amino-2-oxopentanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43169", "l": "adenosine(34) in tRNA + H(+) + H2O => inosine(34) in tRNA + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12097", "l": "H2O + N-benzylformamide => benzylamine + formate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45652", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.111"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391933", "l": "EP3 receptor can bind PGE2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55026", "l": "(3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25627", "l": "H2O2 + imidazole-4-acetaldehyde + NH4(+) => H2O + histamine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50733", "l": "4-hydroxyphenylacetonitrile + O2 + reduced [NADPH--hemoprotein reductase] => (S)-4-hydroxymandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56415", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-ditetradecanoyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944215", "l": "Association of procollagen type XX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46052", "l": "U6 RNA 3'-terminal UU = U6 RNA 3'-terminal uridine 2',3'-cyclic phosphate + uridine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2396337", "l": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45523", "l": "[phycoerythrocyanin alpha-subunit]-Cys(84)-phycoviolobilin <=> (2R,3E)-phycocyanobilin + apo-[phycoerythrocyanin alpha-subunit]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140382", "l": "tryptamine 4-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36506", "l": "(9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA <=> (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174786", "l": "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22313", "l": "5-(methylsulfanyl)-D-ribose + ATP => ADP + H(+) + S-methyl-5-thio-alpha-D-ribose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940032", "l": "TWIST1 binds the RUNX2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45559", "l": "H2O + N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-dodecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42460", "l": "dibenzofuran + H(+) + NADH + O2 = biphenyl-2,2',3-triol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30150", "l": "FADH2 + NAD(+) <=> FAD + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050276", "l": "scyllo-inosamine 4-kinase activity"}, {"i": "MetaCyc:SCYLLO-INOSAMINE-KINASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016277", "l": "[myelin basic protein]-arginine N-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011543", "l": "DCA binds PDK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050998", "l": "nitric-oxide synthase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905594", "l": "resveratrol binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3223236", "l": "RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23707", "l": "GTP + 3 H2O <=> 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016497", "l": "substance K receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56635", "l": "H2O + neryl diphosphate <=> 1,8-cineole + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218821", "l": "PDK1 phosphorylates PKC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071074", "l": "eukaryotic initiation factor eIF2 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5632738", "l": "DDIT4 binds 14-3-3 dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46885", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018834", "l": "dichloromethane dehalogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51184", "l": "1-octadecanoyl-sn-glycero-3-phosphoserine + H2O = H(+) + octadecanoate + sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1362485", "l": "GHBP binds GH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15303", "l": "aldehydo-D-apiose + H(+) + NADH => D-apiitol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1912357", "l": "ITCH ubiquitinates DTX (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198508", "l": "malate + NAD+ <=> oxaloacetate + NADH + H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102449", "l": "kaempferol 3-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-13935"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420980", "l": "Activation of Ca permeable AMPA receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39160", "l": "(3R)-hydroxyhexadecanoyl-CoA => (2E)-hexadecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018800", "l": "5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34185", "l": "alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+) => alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8870469", "l": "RGGT geranylgeranylates RAB proteins (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63167", "l": "H2O + N-tricosanoyl-taurine <=> taurine + tricosanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018666", "l": "2,4-dichlorophenol 6-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1253343", "l": "WWOX binds ERBB4s80 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66034", "l": "alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose => alpha-D-mannose 1-phosphate + GDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66284", "l": "tomatidine + UDP-alpha-D-glucose = H(+) + tomatidine 3-O-beta-D-glucopyranoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25886", "l": "H(+) + N(2)-succinyl-L-citrulline + phosphate => carbamoyl phosphate + N(2)-succinyl-L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28724", "l": "(S)-allantoin(in) + H(+)(in) => (S)-allantoin(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033509", "l": "USP9X binds Ub:PEX5L (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64348", "l": "2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H(+) = deacetylpyripyropene E"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4720478", "l": "Defective ALG9 does not add the seventh mannose to the N-glycan precursor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161733", "l": "PGD2 is dehydrated to PGJ2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11423", "l": "NADPH + O2 + senecionine <=> H2O + NADP(+) + senecionine N-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20682", "l": "cis-zeatin + UDP-alpha-D-glucose => H(+) + O-beta-D-glucosyl-cis-zeatin + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031516", "l": "far-red light photoreceptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63930", "l": "2 [Fe(III)-cytochrome b5] + an N-acyl-sphinga-4E,14Z-dienine + 2 H2O => 2 [Fe(II)-cytochrome b5] + an N-acylsphing-4-enine + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21097", "l": "3-dehydroquinate => 3-dehydroshikimate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47997", "l": "1,6-dihydro-beta-NAD + H(+) + O2 => H2O2 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56201", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-alpha-D-galactose => H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005458", "l": "GDP-mannose transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851933", "l": "MET phosphorylates GAB1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5138459", "l": "WNT5A:FZD4 is endocytosed (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57806", "l": "4-chlorocatechol + NAD(+) + nitrite => 1-chloro-3-nitrobenzene + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58780", "l": "a 5'-triphospho-guanosine-ribonucleotide-snRNA + S-adenosyl-L-methionine = a 5'-methyltriphosphate-guanosine-ribonucleotide-snRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-481010", "l": "Surface deployment of platelet dense granule membrane components (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018701", "l": "2,5-dichlorohydroquinone reductive dehalogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429497", "l": "SLP-76 stimulates PLC gamma 2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19535", "l": "CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+) => 2 H(+) + 2 H2O + N(2)-succinyl-L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34602", "l": "15-methylhexadecasphinganine + NADP(+) <=> 3-dehydro-15-methylhexadecasphinganine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6810076", "l": "DDO oxidizes D-Asp to OA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59101", "l": "diglucosyl-enterobactin + UDP-alpha-D-glucose => H(+) + triglucosyl-enterobactin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33150", "l": "ATP + daunorubicin(in) + H2O <=> ADP + daunorubicin(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39789", "l": "19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8870461", "l": "RABGGTA and RABGGTB bind (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49257", "l": "2-amino-2-deoxy-D-gluconate(out) + N(pros)-phospho-L-histidyl-[protein] => 2-amino-2-deoxy-D-gluconate 6-phosphate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36980", "l": "(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47720", "l": "H(+) + H2O + isoguanine = NH4(+) + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39417", "l": "(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+) => (2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46061", "l": "(11E)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (5Z,11E)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.88", "l": "\"L-glutamate gamma-semialdehyde dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36167", "l": "a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate"}, {"i": "EC:3.1.3.89", "l": "\"5'-deoxynucleotidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1606273", "l": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611030", "l": "GluN1 (GRIN1) binds to ACTN2 at postsynaptic density (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018794", "l": "RHOV binds effectors at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004555", "l": "alpha,alpha-trehalase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682863", "l": "RNF168 binds DNA DSBs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32977", "l": "2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-L-serine => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63590", "l": "prunetin-4'-O-beta-D-glucuronide + UDP => prunetin + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.-", "l": "\"Serine endopeptidases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106321", "l": "S-(hydroxymethyl)glutathione dehydrogenase NADP activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19152", "l": "L-arginyl-[protein] + NAD(+) <=> H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22953", "l": "O2 + octanedioyl-CoA => (2E)-octenedioyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12723", "l": "H(+) + S-methyl-5'-thioadenosine + spermidine => putrescine + S-adenosyl 3-(methylsulfanyl)propylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19578", "l": "luteolin + UDP-alpha-D-glucose => H(+) + luteolin 7-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25717", "l": "H(+) + H2O + N,N-dihydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48155", "l": "ganglioside GD1b(d18:1(4E)/18:0) + H2O <=> ganglioside GM1 (d18:1(4E)/18:0) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49551", "l": "H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] <=> H(+) + L-arginyl-[protein] + lactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11425", "l": "ATP + L-threonyl-[myosin heavy-chain] => ADP + H(+) + O-phospho-L-threonyl-[myosin heavy-chain]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050567", "l": "glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070506", "l": "high-density lipoprotein particle receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008894", "l": "PTPNs gene transcription and translation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019108", "l": "aryl-aldehyde dehydrogenase (NAD) activity"}, {"i": "MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070140", "l": "SUMO-specific isopeptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46008", "l": "CoA + NAD(+) + pentanal = H(+) + NADH + pentanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59553", "l": "N,N',N'',N'''-tetraacetylchitotetraose + O2 => H2O2 + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57104", "l": "[(1->4)-alpha-D-galacturonosyl](n) = 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-2)"}, {"i": "EC:4.2.2.9", "l": "\"Pectate disaccharide-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52444", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose = 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17090", "l": "2-dehydro-3-deoxy-6-phospho-D-gluconate => D-glyceraldehyde 3-phosphate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20228", "l": "(E)-caffeate + S-adenosyl-L-methionine <=> (E)-ferulate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22677", "l": "chlorophyllide a + H(+) + NADPH + O2 => 7(1)-hydroxychlorophyllide a + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204850", "l": "Interaction of Tie2 and Dok-2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59237", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + isoelisabethatriene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37410", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine <=> 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684008", "l": "NBN binds KPNA2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.140", "l": "\"Alternansucrase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9645598", "l": "RRAGC,D hydrolyzes GTP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37482", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31305", "l": "an oxidized flavin + 2 H(+) + NADH => a reduced flavin + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34106", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45614", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine => H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14832", "l": "hydrogen sulfide + O-acetyl-L-serine <=> acetate + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624611", "l": "FOXO1,FOXO3,(FOXO4) bind FBXO32 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61608", "l": "[DsbB protein]-dithiol + a quinone = [DsbB protein]-disulfide + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8863727", "l": "STON2 is neddylated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45588", "l": "a long-chain fatty acid + ATP + holo-[ACP] = a long-chain fatty acyl-[ACP] + AMP + diphosphate"}, {"i": "EC:6.2.1.20", "l": "\"Long-chain-fatty-acid--[acyl-carrier-protein] ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50726", "l": "(Z)-(4-hydroxyphenyl)acetaldehyde oxime => (E)-4-hydroxyphenylacetaldehyde oxime"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30033", "l": "cis,cis-muconate + H(+) => (S)-muconolactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41070", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59972", "l": "decanoyl-CoA + L-seryl-[protein] = CoA + O-decanoyl-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15654", "l": "ATP + beta-D-fructose 6-phosphate => ADP + beta-D-fructose 2,6-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5679239", "l": "ULK complex translocates to the ER (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18059", "l": "CO2 + hnu + oxidized Watasenia luciferin => O2 + Watasenia luciferin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17500", "l": "formononetin + UDP-alpha-D-glucose <=> ononin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61766", "l": "H(+) + rebaudioside E + UDP => stevioside + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196773", "l": "COASY phosphorylates DP-CoA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44808", "l": "1,4-dihydroxy-2-naphthoate + all-trans-decaprenyl diphosphate + H(+) = 2-demethylmenaquinol-10 + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032977", "l": "membrane insertase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60044", "l": "beta-D-Gal-(1<->1')-Cer + UDP-alpha-D-galactose = alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37820", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37705", "l": "1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17247", "l": "6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2 => 3-hydroxyanthranilate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445067", "l": "NrCAM binds axonin-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22359", "l": "diphosphate + oxaloacetate <=> CO2 + phosphate + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696547", "l": "STAMBPL1 is a deubiquitinase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.41"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12449", "l": "(R)-pantothenate + H2O => (R)-pantoate + beta-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936563", "l": "ISGylation of DDX58 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6790454", "l": "SUMOylation of XPC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189069", "l": "sucrose + H2O => glucose + fructose (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16031", "l": "beta-alanine + urea => 3-guanidinopropanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016212", "l": "kynurenine-oxoglutarate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683831", "l": "CCDC59 binds TTF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54677", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (+)-kolavenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951951", "l": "RUNX3 binds EP300 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944261", "l": "Association of procollagen type XIII (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37354", "l": "cytidine 2'-phosphate + H2O <=> cytidine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27463", "l": "diphosphate + GDP-D-glycero-alpha-D-manno-heptose => D-glycero-alpha-D-manno-heptose 1-phosphate + GTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694409", "l": "Nucleotide exchange on RAB1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34771", "l": "a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) = a 3-oxosteroid + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66233", "l": "IC-asc-C7-CoA + O2 => H2O2 + IC-asc-DeltaC7-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689317", "l": "Formation of the pre-incision complex in GG-NER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12414", "l": "(R)-glycerate + phosphate => (2R)-3-phosphoglycerate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38368", "l": "8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA => 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63969", "l": "2 3-(4-hydroxyphenyl)pyruvate + H(+) => atromentin + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61170", "l": "H(+) + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP => quercetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49865", "l": "(+)-dehydrodiconiferyl acid + 2 a quinone + H2O => (+)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14104", "l": "[eIF5A protein]-deoxyhypusine + AH2 + O2 <=> [eIF5A protein]-hypusine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437118", "l": "GPVI stimulates PI3K beta, gamma (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25898", "l": "acetate + CO2 => H(+) + malonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46577", "l": "(24R)-ethylcholest-5-en-3beta-ol + H(+) + NADPH + O2 => 2 H2O + NADP(+) + stigmasterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851908", "l": "Activated MET binds GAB1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050397", "l": "Watasenia-luciferin 2-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191299", "l": "Squalene is oxidized to its epoxide (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35863", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004070", "l": "aspartate carbamoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39934", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140381", "l": "4-hydroxytryptamine 4-phosphate methyltransferase activity"}, {"i": "RHEA:55568", "l": "4-hydoxytryptamine 4-phosphate + 2 S-adenosyl-L-methionine = 2 H(+) + psilocybin + 2 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.345", "l": "\"Psilocybin synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071857", "l": "beta-endorphin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57340", "l": "3-hydroxy-L-kynurenine + S-adenosyl-L-methionine = 3-hydroxy-4-methyl-L-kynurenine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62084", "l": "ADP + D-glucosamine = AMP + D-glucosamine 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042658", "l": "MHC class II protein binding, via antigen binding groove"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63195", "l": "[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + O2 <=> glycine betaine + 2 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56380", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 chloride + 2 FADH2 + 2 O2 = (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 FAD + 4 H2O"}, {"i": "EC:1.14.19.56", "l": "\"1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] chlorinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52310", "l": "2-oxoglutarate + H(+) + NADPH => 2-hydroxyglutarate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61095", "l": "H2O + N(2)-acetyl-L-citrulline <=> acetate + L-citrulline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61485", "l": "a cytidine in rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20600", "l": "2 L-cysteine + NAD(+) <=> H(+) + L-cystine + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14476", "l": "a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) <=> a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181351", "l": "LEFTY binds the EGF-CFC coreceptor in the NODAL receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49671", "l": "H(+) + NADH + O2 + protodeoxyviolaceinate <=> deoxyviolaceinate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29431", "l": "ATP + phosphate = ADP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27976", "l": "7-carboxy-7-deazaguanine + NH4(+) => 6-carboxy-5,6,7,8-tetrahydropterin + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875817", "l": "MET phosphorylates STAT3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.2.-", "l": "\"Linked to the hydrolysis of a nucleoside triphosphate\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30265", "l": "2 H2O + 2 monodehydro-L-ascorbate radical => H2O2 + 2 L-ascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43781", "l": "2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58181", "l": "(1R,2R,3R)-prephytoene diphosphate + H(+) + NADPH => all-trans-lycopaoctaene + diphosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44250", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36072", "l": "6-tuliposide A => D-glucose + tulipalin A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58178", "l": "all-trans-lycopaoctaene + 2 diphosphate + NADP(+) => 2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46006", "l": "2-methylpropanoyl-CoA + H(+) + NADH => 2-methylpropanal + CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29456", "l": "D-serine(in) => D-serine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53728", "l": "H2O + N-acetyl-D-muramate 6-phosphate = N-acetyl-D-muramate + phosphate"}, {"i": "EC:3.1.3.105", "l": "\"N-acetyl-D-muramate 6-phosphate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195275", "l": "Phosphorylation of APC component of the destruction complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036121", "l": "double-stranded DNA helicase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592252", "l": "Expression of TFB2M (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35369", "l": "isoheptadecanoyl-coA + NADP(+) => (2E)-15-methylhexadecenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205649", "l": "p62 links damaged mitochondria to LC3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16188", "l": "an aldehyde + H2O + NAD(+) <=> a carboxylate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59656", "l": "D-cellotriose + O2 = D-cellotriono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102124", "l": "gibberellin A12 16alpha,17 epoxidase activity"}, {"i": "MetaCyc:RXN-11387"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983845", "l": "p-STAT1 dissociates from IL6ST:IL6ST (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351894", "l": "Caspase mediated cleavage of BAP31 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63080", "l": "AH2 + ATP + ilicicolinate B = A + AMP + diphosphate + ilicicolin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35277", "l": "3-oxooctadecanoyl-CoA + H(+) + NADH => 3-hydroxyoctadecanoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9676160", "l": "AAMP binds NOD2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58373", "l": "(E)-oct-2-en-1-ol + NADP(+) => (2E)-octenal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72697", "l": "Start codon recognition (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2169046", "l": "Degradation of TGF-beta receptor complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75244", "l": "FASL binds FAS Receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "79.682896251205548", "identifiers": [{"i": "GO:0042054", "l": "histone methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55501", "l": "ent-cassa-12,15-dien-2beta,3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-178208", "l": "SMAD7 binds to SMURF2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53772", "l": "chenodeoxycholate + lithocholoyl-CoA = chenodeoxycholoyl-CoA + lithocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209165", "l": "ID1 sequesters ETS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1237119", "l": "Acireductone is oxidized to MOB (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33771", "l": "a 1,2-diacyl-sn-glycerol + CDP-N-methylethanolamine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655828", "l": "Expression of Lanosterol Synthase (LSS) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65789", "l": "diuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-(3,4-dichlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180855", "l": "Translocation of Vpr to the mitochondria (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14774", "l": "2 NADPH + palmatine + S-adenosyl-L-methionine => corydaline + 2 NADP(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53752", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-beta-D-galactopyranosyl]-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9687638", "l": "MLKL binds IP4, IP5 and IP6  (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64893", "l": "holo-[ACP] + tetradecanoyl-AMP => AMP + H(+) + tetradecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168038", "l": "Collagen type XV restin release (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59053", "l": "D-lysine + H(+) => cadaverine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432688", "l": "trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34874", "l": "methanol(out) <=> methanol(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605632", "l": "Both hexosaminidase A and B can cleave GalNAc from globoside (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855131", "l": "VLDLR:PCSK9 binds Clathrin-coated vesicles (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73596", "l": "dCMP + H2O => dUMP + NH4+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534388", "l": "Progesterone Activation Of CatSper (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62771", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001155", "l": "TFIIIA-class transcription factor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56113", "l": "2-all-trans-nonaprenylphenol + H(+) + NADPH + O2 => 3-(all-trans-nonaprenyl)benzene-1,2-diol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210439", "l": "glutamate uptake by astrocytes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35240", "l": "tetracycline(in) => tetracycline(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204981", "l": "14-3-3epsilon attentuates NADE-related apoptosis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45377", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4720432", "l": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9692809", "l": "CDC42 binds effectors at the ER membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43996", "l": "2-oxoglutarate + a 3-methyl fatty acyl-CoA + O2 = a 2-hydroxy-3-methyl fatty acyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43860", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211948", "l": "CYP3A4 can N-demethylate loperamide (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56234", "l": "[(1->4)-alpha-D-galacturonosyl](n-2) + alpha-D-galacturonosyl-(1->4)-D-galacturonate => [(1->4)-alpha-D-galacturonosyl](n) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396029", "l": "Latent TGF-beta-3 binds integrins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25095", "l": "ATP + dCMP => ADP + dCDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57161", "l": "2-oxoglutarate + L-arginyl-[ribosomal protein eS6] + O2 => (3R)-3-hydroxy-L-arginyl-[ribosomal protein eS6] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691174", "l": "RAC1 binds effectors at the ER membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852362", "l": "GTSE1 binds CDKN1A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20625", "l": "2 [Fe(III)-cytochrome c3] + H2 = 2 [Fe(II)-cytochrome c3] + 2 H(+)"}, {"i": "EC:1.12.2.1", "l": "\"Cytochrome-c3 hydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60687", "l": "(11R)-dihydroartemisinic aldehyde + H2O + NADP(+) <=> (11R)-dihydroartemisinate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61187", "l": "quercitrin + UDP-beta-L-rhamnose <=> H(+) + quercetin 3,7-bis-O-alpha-L-rhamnoside + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008502", "l": "melatonin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2467775", "l": "Autocleavage of ESPL1 (Separase) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23211", "l": "acetyl-CoA + trans-glutaconate <=> (2E)-glutaconyl-CoA + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12385", "l": "5,6-dihydrouracil + O2 => H2O2 + uracil"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395340", "l": "Formation of hydroxyallysine by LOX (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42177", "l": "(9Z)-tetradecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-tetradecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74885", "l": "GUCYs converts GTP to cGMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052677", "l": "D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070404", "l": "NADH binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.2.12", "l": "\"Phosphoglycerate mutase (2,3-diphosphoglycerate-independent)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53170", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018766", "l": "RHOU binds effectors at the plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29167", "l": "H2O + pyruvate + ubiquinone-8 = acetate + CO2 + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16599", "l": "ADP + CTP + 2 H(+) + phosphate => ATP + NH4(+) + UTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24028", "l": "2-oxoglutarate + 4-(trimethylamino)butanoate + O2 = carnitine + CO2 + succinate"}, {"i": "EC:1.14.11.1", "l": "\"Gamma-butyrobetaine dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22557", "l": "(S)-malate + A => AH2 + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9011543", "l": "DCA binds PDK2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372449", "l": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57006", "l": "CoA + H(+) + N(beta)-acetylstreptothricin D => acetyl-CoA + streptothricin D"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34298", "l": "2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose <=> 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30788", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 => (6R)-L-erythro-6,7-dihydrobiopterin + H2O + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33454", "l": "A + H2O + N(6),N(6)-dimethyl-L-lysyl-[protein] <=> AH2 + formaldehyde + N(6)-methyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655266", "l": "Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54194", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine => L-lysyl-[protein] + 3 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008433", "l": "RUNX2 binds CDKN1A gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174367", "l": "GCL ligates L-Glu to L-Cys (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204169", "l": "PDP dephosphorylates p-lipo-PDH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3204311", "l": "AOX1 oxidises PXL to PDXate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373707", "l": "Netrin-1 induced DCC clustering (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55160", "l": "coenzyme B + coenzyme M + 2 oxidized [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B heterodisulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.8.7.3", "l": "\"Ferredoxin:CoB-CoM heterodisulfide reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372542", "l": "Loading of dopamine into synaptic veiscles (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9670101", "l": "ATRX:DAXX binds to subtelomeric chromosomal regions (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16715", "l": "glutathione + H(+) + succinate => H2O + S-succinylglutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42601", "l": "AH2 + prostaglandin G2 => A + H2O + prostaglandin H2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189069", "l": "sucrose + H2O => glucose + fructose (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50580", "l": "acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668404", "l": "TNFA binds TNFR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16171", "l": "ADP + H(+) + L-glutamine + phosphate => ATP + L-glutamate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169406", "l": "ISGylation of host proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52026", "l": "18S-resolvin E2 + A + H2O => (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353426", "l": "TDG glycosylase mediated recognition and binding of thymine opposite guanine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047137", "l": "N-hydroxy-2-acetamidofluorene reductase activity"}, {"i": "MetaCyc:1.7.1.12-RXN"}, {"i": "EC:1.7.1.12", "l": "\"N-hydroxy-2-acetamidofluorene reductase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047295", "l": "geranylgeranylglycerol-phosphate geranylgeranyltransferase activity"}, {"i": "RHEA:18109", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate"}, {"i": "EC:2.5.1.42", "l": "\"Geranylgeranylglycerol-phosphate geranylgeranyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18120", "l": "L-tyrosine + O2 <=> H2O + L-dopaquinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427528", "l": "Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789218", "l": "Hypochlorous acid (HOCl) reacts with unsaturated lipid to form lipid chlorohydrins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022852", "l": "glycine-gated chloride ion channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46018", "l": "H(+) + NADH + progesterone => (20R)-20-hydroxypregn-4-en-3-one + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39316", "l": "(3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA => (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11778", "l": "(9Z)-octadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55541", "l": "40 ATP + 40 H2O + N2 + 12 reduced [2Fe-2S]-[ferredoxin] => 40 ADP + 26 H(+) + 3 H2 + 2 NH4(+) + 12 oxidized [2Fe-2S]-[ferredoxin] + 40 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57323", "l": "acetyl-CoA + N-terminal L-(Asp/Glu)3-[protein] <=> CoA + H(+) + N-terminal N-acetyl-L-(Asp/Glu)3-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41803", "l": "acetyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193668", "l": "p75NTR and RHOA-GDI interact (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250280", "l": "ROS oxidize thioredoxin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16546", "l": "formyl-CoA + oxalate => formate + oxalyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427570", "l": "Group 3 - Selective Cl- transport (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.1.-", "l": "\"Linked to oxidoreductase reactions\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35184", "l": "5-hydroxythiophene-2-carbonyl-CoA + H2O => 4-carboxy-2-thioxobutanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2318585", "l": "Defective HYAL1 does not hydrolyse Chondroitin chains (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16090", "l": "H2O + phosphoethanolamine => ethanolamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58758", "l": "1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3266557", "l": "Factor I cleaves iC3b (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050490", "l": "1,4-lactonase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60919", "l": "a cytidine in mRNA + S-adenosyl-L-methionine <=> an N(3)-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983011", "l": "Expression of STAT5 upregulated genes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63655", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47556", "l": "H2O + taurodeoxycholate = deoxycholate + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28298", "l": "(2E,6E)-farnesyl diphosphate = (E)-gamma-bisabolene + diphosphate"}, {"i": "EC:4.2.3.59", "l": "\"(E)-gamma-bisabolene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17820", "l": "(3R)-hydroxytetradecanoyl-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine <=> H(+) + holo-[ACP] + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40086", "l": "hexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 26-hydroxyhexacosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42870", "l": "caldopentamine + 2 H(+) + S-methyl-5'-thioadenosine => norspermine + S-adenosyl 3-(methylsulfanyl)propylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015575", "l": "mannitol transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626220", "l": "C2CD3 binds the mother centriole (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0003924", "l": "GTPase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211960", "l": "CYP2U1 19-hydroxylates ARA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12265", "l": "2',4,4',6'-tetrahydroxychalcone + H(+) + O2 => aureusidin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-179421", "l": "Degradation of multiubiquitinated Nek2A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30891", "l": "O-acetyl-L-serine + thiosulfate = acetate + H(+) + S-sulfo-L-cysteine"}, {"i": "EC:2.5.1.144", "l": "\"S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5610726", "l": "The IFT-A complex recruits TULP3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16318", "l": "(S)-indan-1-ol + NAD(+) => H(+) + indan-1-one + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25689", "l": "H(+) + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys) <=> L-cysteinyl-tRNA(Cys) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19048", "l": "acetyl-CoA + H2O + pyruvate <=> (3R)-citramalate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75862", "l": "Fall Back to Closed Pre-initiation Complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32262", "l": "beta-D-fructose 1-phosphate + methylglyoxal <=> 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981814", "l": "GalNAc alpha-2,6-sialyltransferase II can add a sialic acid to the T antigen at the alpha 6 position (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38621", "l": "H(+) + nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside => nicotinate beta-D-ribonucleotide + phenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46568", "l": "5-hexenoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 5-hexynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "RHEA:46572", "l": "2 H(+) + hexanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 5-hexenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.19.40", "l": "\"Hex-5-enoyl-[acyl-carrier protein] acetylenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41403", "l": "1-hexanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexanoyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449117", "l": "TXLNA (IL14) binds syntaxin1A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21867", "l": "an S-(2-hydroxyacyl)glutathione + H2O <=> a 2-hydroxy carboxylate + glutathione + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51236", "l": "GTP + L-glutamate + oxidized coenzyme F420-(gamma-Glu)(n) = GDP + H(+) + oxidized coenzyme F420-(gamma-Glu)(n+1) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199299", "l": "AKT phosphorylates FOXO transcription factors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34204", "l": "2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 => aureusidin 6-O-beta-glucoside + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36193", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + ethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54547", "l": "1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine <=> 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419389", "l": "LPA-binding receptors bind LPA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46365", "l": "2 [Fe(II)-cytochrome b5] + an N-acylsphinganine + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + an N-acyl-(4R)-4-hydroxysphinganine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000247", "l": "Endosomal CBLIF:Cbl translocates to lysosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33600", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + N-hexacosanoylsphinganine + O2 => 2 [Fe(III)-cytochrome b5] + H2O + N-hexacosanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111883", "l": "Hydrolysis of phosphatidylcholine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951966", "l": "EP300 acetylates RUNX3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050345", "l": "trans-epoxysuccinate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59995", "l": "H(+) + oxidized [electron-transfer flavoprotein] + phloretate <=> (E)-4-coumarate + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57100", "l": "S-methyl-5-thio-D-ribulose 1-phosphate = S-methyl-1-thio-D-xylulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42526", "l": "pseudouridine(1911/1915/1917) in 23S rRNA => uridine(1911/1915/1917) in 23S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454928", "l": "ABCG4 may mediate cholesterol efflux (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43893", "l": "[sulfur carrier]-H + L-cysteine => [sulfur carrier]-SH + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58936", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADH = all-trans-lycopaoctaene + 2 diphosphate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052682", "l": "epi-cedrol synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19726", "l": "H(+) + UDP-alpha-D-galacturonate => CO2 + UDP-beta-L-arabinopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218806", "l": "FYN autophosphorylates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52564", "l": "2-dehydro-L-erythronate = 3-dehydro-L-erythronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692779", "l": "p-S182 MAPKAPK5 phosphorylates FOXO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49024", "l": "L-tryptophan + O2 = 2-iminio-3-(indol-3-yl)propanoate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15194", "l": "dGTP + H2O => 2'-deoxyguanosine + H(+) + triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982645", "l": "GRKs bind ADRB2:Catecholamine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57020", "l": "apulose + ATP = ADP + apulose 4-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204434", "l": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20650", "l": "23,24-dihydrocucurbitacin B + NADP(+) => cucurbitacin B + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52483", "l": "16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32956", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23934", "l": "an N-acyl-D-mannosamine 6-phosphate => an N-acyl-D-glucosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139909", "l": "Translocation of BMF to mitochondria (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53099", "l": "4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine <=> 4-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.44", "l": "\"Nodavirus endopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24383", "l": "(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33428", "l": "(S)-malyl alpha-D-glucosaminide + L-cysteine => bacillithiol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50194", "l": "3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP => L-seryl-[protein] + UDP-alpha-D-xylose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193832", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45962", "l": "4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 24,25-dihydrolanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696267", "l": "RND3 binds GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24199", "l": "(2R,4S)-2,4-diaminopentanoate + H2O + NAD(+) <=> (2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036008", "l": "Defective MAN1B1 does not hydrolyse a second 1,2-linked mannose (a branch) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202110", "l": "eNOS:Caveolin-1 complex binds to CaM (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46565", "l": "acetyl-CoA + apo-[ACP] => acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40197", "l": "1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40811", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8979071", "l": "KDM6B binds iron (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63280", "l": "a 1-acyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 = a 1-acyl-2-(15-hydroperoxy-8Z,11Z,13E-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19980", "l": "3'-phosphoadenylyl sulfate + L-tyrosine methyl ester <=> adenosine 3',5'-bisphosphate + H(+) + L-tyrosine methyl ester 4-sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64137", "l": "H2O + N-(9Z-octadecenoyl)-L-asparagine => (9Z)-octadecenoate + L-asparagine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5628899", "l": "TP53 binds the TIGAR gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444661", "l": "HCAR2 binds HCAR2 ligands (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169402", "l": "ISGylation of E2 conjugating enzymes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14410", "l": "cysteamine + O2 => H(+) + hypotaurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58546", "l": "H2O + 2 monodehydro-L-ascorbate radical + N-tetradecanoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-tetradecanoylglycine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730902", "l": "Oligomerization of p-CARMA1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5576895", "l": "SCNAs:SNCBs transport Na+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40049", "l": "1,2-dioctanoyl-sn-glycerol + H(+) + octanoate => 1,2,3-trioctanoylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28284", "l": "(S)-beta-macrocarpene => (S)-beta-bisabolene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989757", "l": "Expression of FADS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43421", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + ATP => 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59965", "l": "L-seryl-[protein] + octanoyl-CoA => CoA + O-octanoyl-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5632738", "l": "DDIT4 binds 14-3-3 dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000823", "l": "inositol-1,4,5-trisphosphate 6-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52505", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => 9(R)-hydroxy-(10E,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61235", "l": "H2O + L-isoleucine + O2 <=> (S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106370", "l": "protein-L-histidine N-pros-methyltransferase activity"}, {"i": "RHEA:67076", "l": "L-histidyl-[protein] + S-adenosyl-L-methionine = H(+) + N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11882", "l": "6-hydroxypseudooxynicotine + H2O2 => (S)-6-hydroxynicotine + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389354", "l": "Activation of Vav1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797957", "l": "BET translocates from mitochondrial matrix to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854052", "l": "Formation of the SCF-FBXL7 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55201", "l": "5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine => 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696960", "l": "USP49 deubiquitinates H2B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43130", "l": "H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine => guanosine(10) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901973", "l": "proline binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53760", "l": "allocholate + deoxycholoyl-CoA = allocholoyl-CoA + deoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16136", "l": "H2O + N(1)-acetylspermine + O2 <=> 3-aminopropanal + H2O2 + N(1)-acetylspermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876497", "l": "InlA binds CDH1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264622", "l": "Cho is acetylated to AcCho by CHAT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47350", "l": "an aliphatic alcohol + butanoate + H(+) => a butanoate ester + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654569", "l": "Activated FGFR1 binds FRS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678998", "l": "Endosomal TLRs pass through the Golgi (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21036", "l": "2 acetyl-CoA = acetoacetyl-CoA + CoA"}, {"i": "EC:2.3.1.9", "l": "\"Acetyl-CoA C-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102475", "l": "2-hydroxyeriodictyol 6C-glucoside dehydratase activity"}, {"i": "MetaCyc:RXN-14081"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008510", "l": "sodium:bicarbonate symporter activity"}, {"i": "REACT:R-HSA-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61643", "l": "H(+) + isophthalyl-CoA <=> benzoyl-CoA + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031473", "l": "myosin III binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16930", "l": "2 benzoyl-CoA + L-ornithine => 2 CoA + 2 H(+) + N(2),N(5)-dibenzoyl-L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60527", "l": "5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine <=> 5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034954", "l": "diphenyl ether 2,3-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28782", "l": "4-hydroxy-L-threonine <=> glycine + glycolaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433501", "l": "Interaction of other adapter proteins with p-KIT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.18"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051787", "l": "misfolded protein binding"}, {"i": "REACT:R-HSA-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65868", "l": "Delta(1)-dihydrotestosterone + H2O = 1,17beta-dihydroxyandrostan-3-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23161", "l": "L-rhamnopyranose => L-rhamnulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42370", "l": "H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase] => dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210295", "l": "Interaction of DAP12 and NKG2D (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349426", "l": "Phosphorylation of MDM4 by CHEK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418849", "l": "DAPK binds UNC5B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050221", "l": "prostaglandin-E2 9-reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187382", "l": "Degradation of ubiquitinated SMAD3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27736", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate => 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58541", "l": "2 L-ascorbate + N-dodecanoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-dodecanoyl-(2S)-hydroxyglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64648", "l": "(E)-coniferaldehyde + CoA + NADP(+) = (E)-feruloyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428231", "l": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50973", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 => (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1297444", "l": "Binding of cAMP to HCN channels (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39418", "l": "(2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH <=> (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42148", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acyl-(4R)-4-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781897", "l": "USP11 deubiquitinates NFKBIA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730847", "l": "Hydrolysis of PIP2 by PLCG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59314", "l": "D-galactono-1,5-lactone + H2O2 => D-galactose + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56074", "l": "a 2-acylphloroglucinol 1-O-beta-D-glucoside + UDP => a 2-acylphloroglucinol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30268", "l": "2 monodehydro-L-ascorbate radical => L-ascorbate + L-dehydroascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375138", "l": "CDO binds BOC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9032798", "l": "DOCK3 activates RAC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727819", "l": "TAK1 phosphorylates MKK6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015493", "l": "lysine:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61577", "l": "(4R,5R)-4,5-dihydroxycyclohex-2-ene-1-carbonyl-CoA + NADP(+) => (3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-982810", "l": "JAK2 phosphorylation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691154", "l": "HFE binds TFRC dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41698", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + succinate => 1-O-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404193", "l": "IGF1R phosphorylates SHC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34478", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate <=> 15-cis-phytoene + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158832", "l": "The acetyl group from acetyl-CoA is transferred to the NAT2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3364026", "l": "SET1 complex trimethylates H3K4 at the MYC gene (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53135", "l": "A + a 3-oxo-Delta(4)-steroid <=> a 3-oxo-Delta(1,4)-steroid + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983259", "l": "Kinesins move along microtubules consuming ATP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6791221", "l": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21710", "l": "adenosine + L-homocysteine => H2O + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38086", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15453", "l": "S-adenosyl-L-methionine + sarcosine = H(+) + N,N-dimethylglycine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30595", "l": "4-hydroxyphenylacetate + FADH2 + O2 = 3,4-dihydroxyphenylacetate + FAD + H(+) + H2O"}, {"i": "EC:1.14.14.9", "l": "\"4-hydroxyphenylacetate 3-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.136", "l": "\"2-acylphloroglucinol 4-prenyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809764", "l": "SBF1 binds MTMR2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177934", "l": "EGFR autophosphorylation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202692", "l": "PIP3 binds to RhoA and activates it (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24809", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44752", "l": "2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24524", "l": "20-oxo-5-O-beta-D-mycaminosyltylonolide + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 5-O-beta-D-mycaminosyltylonolide + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.15.34", "l": "\"20-oxo-5-O-mycaminosyltylactone 23-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205286", "l": "GRB2:SOS interacts with p-KIT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20770", "l": "CO2 + phosphonoacetaldehyde => 3-phosphonopyruvate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64716", "l": "NADP(+) + propanal = acrolein + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49232", "l": "D-mannose(out) + N(pros)-phospho-L-histidyl-[protein] = D-mannose 6-phosphate(in) + L-histidyl-[protein]"}, {"i": "EC:2.7.1.191", "l": "\"Protein-N(pi)-phosphohistidine--D-mannose phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350651", "l": "Caspase-mediated cleavage of MASK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57000", "l": "acetyl-CoA + streptothricin F = CoA + H(+) + N(beta)-acetylstreptothricin F"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43436", "l": "coproporphyrinogen III + 3 O2 = coproporphyrin III + 3 H2O2"}, {"i": "EC:1.3.3.15", "l": "\"Coproporphyrinogen III oxidase (coproporphyrin-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17782", "l": "H2O + N-formyl-L-methionine => formate + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1370500", "l": "PRLR binds SCF beta-TrCP complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66588", "l": "a cytidine in 26S rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in 26S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13030", "l": "H2O + N-acetyl-D-glucosamine + O2 => H(+) + H2O2 + N-acetyl-D-glucosaminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45400", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016296", "l": "palmitoyl-[acyl-carrier-protein] hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23425", "l": "alpha-D-glucosamine 1-phosphate => D-glucosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17545", "l": "[peroxiredoxin]-S-hydroxy-S-oxy-L-cysteine + [protein]-dithiol + ATP = [peroxiredoxin]-S-hydroxy-L-cysteine + [protein]-disulfide + ADP + H(+) + phosphate"}, {"i": "EC:1.8.98.2", "l": "\"Sulfiredoxin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14058", "l": "a 1,2-diacyl-sn-glycerol + a glycerophospholipid => a monoacylglycerophospholipid + a triacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.13.3", "l": "\"Histidine kinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990846", "l": "ribonucleoside-diphosphate reductase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41278", "l": "H2O + N-eicosanoyl-sphing-4-enine <=> eicosanoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47598", "l": "an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy- beta-D-glucuronosyl)-N-acetyl- alpha-D-glucosaminyl phosphate + H(+) + UDP => an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939829", "l": "ITGBL1 gene expression is stimulated by RUNX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53188", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68611", "l": "Formation of ORC(1-5) complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53201", "l": "17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] => 17beta,19-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682769", "l": "LGI2 binds ADAM22,23 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63610", "l": "apelin-16 + L-phenylalanine => apelin-17 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31250", "l": "H(+) + prop-2-ynal + pyrroloquinoline quinol <=> prop-2-yn-1-ol + pyrroloquinoline quinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51484", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005176", "l": "ErbB-2 class receptor binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005521", "l": "lamin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41541", "l": "8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + S-adenosyl-L-methionine => 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14645", "l": "H2O + S-adenosyl-L-methionine = H(+) + L-homoserine + S-methyl-5'-thioadenosine"}, {"i": "EC:3.3.1.2", "l": "\"S-adenosyl-L-methionine hydrolase (L-homoserine-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16507", "l": "4-hydroxybenzoate + pyruvate => chorismate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47574", "l": "CMP + ganglioside GT1b (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1b (d18:1(4E))"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15999", "l": "2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NAD(+) => anthraniloyl-CoA + 2 H(+) + 2 NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936380", "l": "Interaction of PIN1 with p-IRF3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483219", "l": "PC is exchanged with PI by PITPNB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102149", "l": "farnesylcysteine lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28185", "l": "(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate <=> (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047769", "l": "arogenate dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11030", "l": "ADP + D-mannose 6-phosphate + H(+) => ATP + D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686930", "l": "RIPK3 is cleaved by CASP8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674529", "l": "AAMP binds to TBXA2R (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46228", "l": "apo-[peptidyl-carrier protein] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681596", "l": "3CLp dimer binds α-Ketoamides (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102749", "l": "dihydrogeranylgeranyl-chlorophyll a reductase activity"}, {"i": "MetaCyc:RXN-7665"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48766", "l": "3-acetyl-3-devinylchlorophyllide a + H(+) + NADH => 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694527", "l": "Loss of SAR1B GTPase (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5695980", "l": "ACAD10 dehydrogenates S-2MPDA-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8856945", "l": "PP2A methylation by LCMT1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28584", "l": "ADP + dUTP => ATP + dUDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36842", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20903", "l": "H(+) + H2O + N-benzyloxycarbonylglycine <=> benzyl alcohol + CO2 + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2396007", "l": "IRF3 is phosphorylated by TBK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47718", "l": "21-hydroxyprogesterone + H(+) + NADH => 4-pregnen-20,21-diol-3-one + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33578", "l": "an inositol-1-phosphophytoceramide + beta-D-mannose <=> a mannosylinositol-1-phosphophytoceramide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10725", "l": "GDP-6-deoxy-alpha-D-talose + NADP(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38515", "l": "1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002935", "l": "tRNA (adenine-C2-)-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11178", "l": "beta-D-glucose 1-phosphate + D-glucose => 2-alpha-D-glucosyl-D-glucose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2059926", "l": "NPHP4 protein binds LATS proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55417", "l": "biochanin A + UDP-alpha-D-glucose => biochanin A 7-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189439", "l": "ALAD condenses 2 dALAs to form PBG (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16789", "l": "a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004735", "l": "pyrroline-5-carboxylate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46511", "l": "NADH + nitrobenzene + O2 <=> catechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627350", "l": "SMAC (DIABLO) binds XIAP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75856", "l": "Abortive Initiation Before Second Transition (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14896", "l": "D-ornithine <=> (2R,4S)-2,4-diaminopentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428609", "l": "Type I Na+-coupled phosphate co-transport (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0005214", "l": "structural constituent of chitin-based cuticle"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28641", "l": "(-)-gamma-cadinene + diphosphate => (2Z,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683113", "l": "Defective ABCC8 does not form functional KATP channels, causing hyperinsulinemic hypoglycemia (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213208", "l": "Type X collagen associates with collagen type II fibrils (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36549", "l": "CoA + H(+) + N-(octadecanoyl)-sphinganine => octadecanoyl-CoA + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53306", "l": "A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate => AH2 + 2 ATP + 2 cob(II)alamin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.10", "l": "\"Carboxypeptidase E\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54071", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O <=> diphosphate + sesterfisherol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5218891", "l": "RIPK1:RIPK3 oligomer binds MLKL (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19858", "l": "a 16alpha-hydroxysteroid + NADP(+) => a 16-oxosteroid + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27938", "l": "(3R)-3-hydroxy-D-aspartate = glycine + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050320", "l": "tartrate epimerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877941", "l": "RUNX2 binds SMAD1 in the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140348", "l": "lysophosphatidylcholine flippase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38628", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA => 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43253", "l": "1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O => 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866277", "l": "AP-2 directly binds some endocytic cargo (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432148", "l": "Fgr may phosphorylate p38 MAPK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10822", "l": "D-erythro-isocitrate => D-threo-isocitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56684", "l": "dihydrorhizobitoxine + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + rhizobitoxine"}, {"i": "EC:1.14.19.61", "l": "\"Dihydrorhizobitoxine desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-398184", "l": "LARG activation by G alpha 12/13 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38269", "l": "3-methylfumaryl-CoA => 2-methylfumaryl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33215", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 3 isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + 3 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29317", "l": "D-galactose + phosphate => alpha-D-galactose 1-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40678", "l": "L-threonine <=> 2-aminobut-2-enoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2514790", "l": "Elastin degradation by MMP14 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66214", "l": "asc-omegaDeltaC5-CoA + H2O2 => asc-omegaC5-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004650", "l": "polygalacturonase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031756", "l": "Edg-3 sphingosine 1-phosphate receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35900", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA => 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60645", "l": "3'-phosphoadenylyl sulfate + 3alpha-hydroxy-5alpha-androstan-17-one => 3alpha-sulfooxy-5alpha-androstan-17-one + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59869", "l": "4-(2,4-dichlorophenoxy)butanoate + ATP + L-glutamine => 4-(2,4-dichlorophenoxy)butanoyl-L-glutamine + AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110011", "l": "Binding of Grb10 to the insulin receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021954", "l": "MECP2 binds OPRK1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51147", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + 2 O2 <=> (10,17)-dihydroperoxy-(7Z,11Z,13Z,15E,19Z)-docosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42204", "l": "corticosterone + NAD(+) = 11-dehydrocorticosterone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004464", "l": "leukotriene-C4 synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210932", "l": "ANTXR2-bound pagA(197-794) forms oligomers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351341", "l": "Exocytosis of Proactivator polypeptide (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106356", "l": "4-hydroxybenzoate 3-monooxygenase [NADPH] activity"}, {"i": "RHEA:19477", "l": "4-hydroxybenzoate + H(+) + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507869", "l": "Aquaporins passively transport glycerol into cells (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.318", "l": "\"Eugenol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203700", "l": "eNOS translocation from Golgi to Caveolae (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41807", "l": "3-oxobutanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxybutanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10395", "l": "(E)-cinnamyl alcohol + NADP(+) <=> (E)-cinnamaldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671772", "l": "p-T38-PPP1R14A binds MLCP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9671145", "l": "DKC1 binds SHQ1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31964", "l": "9beta-pimara-7,15-dien-19-al + O2 + reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662466", "l": "XYLB phosphorylates D-xylulose (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48578", "l": "3-chloro-cis,cis-muconate + 2 H(+) => 4-chlorocatechol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689111", "l": "PARK2 autoubiquitinates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013009", "l": "RHOA binds effectors at the plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047745", "l": "chlorogenate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013159", "l": "CDC42 GEFs activate CDC42 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65880", "l": "1-hydroxy-5alpha-androstan-3,17-dione + A = 5alpha-androstan-1,3,17-trione + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59109", "l": "chenodeoxycholate + octyl beta-D-glucose => beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19107", "l": "4-aminobutanoate + 2 H(+) + NADH => 4-aminobutanal + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679029", "l": "C-ter TLR7 dimer binds HCQ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47621", "l": "2-ethylhexyl sulfate + 2-oxoglutarate + O2 => 2-ethylhexanal + CO2 + H(+) + succinate + sulfate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102334", "l": "N,N'-diacetylbacilliosaminyl-1-phosphate transferase activity"}, {"i": "RHEA:34515", "l": "tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine = N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UMP"}, {"i": "EC:2.7.8.36", "l": "\"Undecaprenyl phosphate N,N'-diacetylbacillosamine 1-phosphate transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034930", "l": "1-hydroxypyrene sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-984689", "l": "Kinesin-7 is a dimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10987", "l": "(S)-lactate + oxaloacetate <=> (S)-malate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43181", "l": "cytidine(2278) in 25S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(2278) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.12", "l": "\"Carboxypeptidase M\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50873", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + O2 => (5,6,15R)-trihydroxy-(7E,9E,11Z,13E,17Z)-eicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429955", "l": "CCR4-NOT complex deadenylates mRNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1973968", "l": "Beta-defensins 4A and 103 bind CCR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6813740", "l": "GDE1 hydrolyzes GroPIns (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52650", "l": "5-phospho-L-arabinonate + H(+) => H2O + L-arabino-1,4-lactone 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3785711", "l": "Telomere shortening during replicative exhaustion (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31774", "l": "an all-trans-retinyl ester + H2O <=> 11-cis-retinol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.164", "l": "\"Galactan endo-1,6-beta-galactosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65465", "l": "2-methylbutan-1-ol + butanoyl-CoA => 2-methylbutyl butanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62937", "l": "H2O + N(4)-acetyl-2'-deoxycytidine => 2'-deoxycytidine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987043", "l": "IL22RA1 binds JAK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2317531", "l": "SREBP1A,1C,2 binds SCAP:INSIG:oxysterol and is retained in the endoplasmic reticulum (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5651828", "l": "PARG dePARylates PARP1,PARP2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.38"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-500717", "l": "Activation of GRIK3 homomer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159761", "l": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10996", "l": "2-methylpropanal oxime + S-adenosyl-L-methionine = 2-methylpropanal O-methyloxime + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.91", "l": "\"Isobutyraldoxime O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45958", "l": "(9Z)-octadecenoyl-CoA(out) => (9Z)-octadecenoyl-CoA(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390929", "l": "HTR1 and 5A receptors can bind serotonin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61945", "l": "24-methylenecholesterol + UDP-alpha-D-glucose => 24-methylene cholesteryl beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9646468", "l": "mTORC1 binds RHEB:GTP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37365", "l": "5 A + beta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O => 5 AH2 + 2 H(+) + heme b + 4 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58076", "l": "1-(11Z-eicosenoyl)-glycerol + H2O = (11Z)-eicosenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46390", "l": "(24S,25R)-24,26-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62885", "l": "O2 + 4 semiviriditoxin => 2 (M)-viriditoxin + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008783", "l": "agmatinase activity"}, {"i": "MetaCyc:AGMATIN-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730841", "l": "Phosphorylation and activation of VAV (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110322", "l": "Formation of Pol zeta complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45520", "l": "[phycoerythrocyanin alpha-subunit]-Cys(84)-phycoviolobilin = (2R,3E)-phycocyanobilin + apo-[phycoerythrocyanin alpha-subunit]"}, {"i": "EC:4.4.1.31", "l": "\"Phycoerythrocyanin alpha-cysteine-84 phycoviolobilin lyase/isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31526", "l": "2-oxoglutarate + 2 H(+) + O2 <=> 3 CO2 + ethene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23932", "l": "an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214857", "l": "DL/DIF dimer binds to TUB and phosphorylated PLL in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421161", "l": "hypoxanthine + H2O + NAD+ => xanthine + NADH + H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21607", "l": "styrene oxide <=> 2-phenylacetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28211", "l": "H2O + L-saccharopine + O2 => (S)-2-amino-6-oxohexanoate + H2O2 + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102267", "l": "tRNA-dihydrouridine20b synthase activity"}, {"i": "MetaCyc:RXN-12476"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35315", "l": "H(+) + hexadecanoyl-CoA + malonyl-CoA = 3-oxooctadecanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62626", "l": "[glutaredoxin]-disulfide + an alcohol + H2O => [glutaredoxin]-dithiol + a hydroperoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41514", "l": "H2O + N(5)-hydroxy-L-ornithine + NAD(+) => L-ornithine + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602466", "l": "Activation of MT-MMPs by FURIN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28339", "l": "(R)-carnitinyl-CoA => crotonobetainyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011074", "l": "LHX2 binds to ROBO1 gene locus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34879", "l": "2 H2O + methyl 3-cyano-2-phenylpropanoate = 4-methoxy-4-oxo-3-phenylbutanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353484", "l": "Uracil glycosylase mediated recognition and binding of uracil opposite guanine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168895", "l": "RNP association (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48829", "l": "H(+) + NADPH + O2 + resorcinol => benzene-1,2,4-triol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44861", "l": "(R)-carnitine + 4,8-dimethylnonanoyl-CoA => CoA + O-4,8-dimethylnonanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46802", "l": "Na(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + Na(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23790", "l": "acetyl-[citrate lyase ACP] + AMP + diphosphate => acetate + ATP + holo-[citrate lyase ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176175", "l": "Stalling of DNA replication fork and RPA binding (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664879", "l": "ATM:PEX5 binds ATM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110322", "l": "Formation of Pol zeta complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58386", "l": "H(+) + NADPH + octanal => NADP(+) + octan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864595", "l": "TFAP2B homodimer binds YEATS4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59494", "l": "(2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate => (2E)-geranyl diphosphate + L-tryptophyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102955", "l": "S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24173", "l": "A + a 3-oxo-5beta-steroid => a 3-oxo-Delta(4)-steroid + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.63", "l": "\"4-acetamidobutyrate deacetylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706323", "l": "Active FLT3 binds to SLA2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018464", "l": "3-hydroxypimeloyl-CoA dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52874", "l": "17alpha-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP => 17alpha-estradiol + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647680", "l": "CASP1 cleaves GSDMD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49196", "l": "2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol = 25-hydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19568", "l": "(2E)-geranyl diphosphate + H2O <=> diphosphate + sabinene hydrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483174", "l": "PE is methylated to PC by PEMT (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785594", "l": "FANCD2 binds FANCI (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57636", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + ML-236A carboxylate = holo-[2-methylbutanoate polyketide synthase] + mevinic carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46547", "l": "2 [Fe(II)-cytochrome b5] + an N-acylsphinganine + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + an N-acylsphing-4-enine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686088", "l": "CASP3 cleaves GSDMD (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29925", "l": "ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855232", "l": "RELN:VLDLR binds DAB1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56898", "l": "an acyl-AMP + diphosphate => a carboxylate + ATP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24392", "l": "dTDP-L-dihydrostreptose + streptidine 6-phosphate = dTDP + H(+) + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate"}, {"i": "EC:2.4.2.27", "l": "\"dTDP-dihydrostreptose--streptidine-6-phosphate dihydrostreptosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5334827", "l": "SUMO-CRABP2 binds atRA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199299", "l": "AKT phosphorylates FOXO transcription factors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168376", "l": "STIM1 oligomerizes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193684", "l": "p62 recruits an atypical PKC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48699", "l": "1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O <=> H(+) + octanoate + octanoyl-3-(beta-D-galactosyl)-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27521", "l": "H2O + sphing-4-enine 1-phosphate <=> phosphate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110322", "l": "Formation of Pol zeta complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047074", "l": "4-hydroxycatechol 1,2-dioxygenase activity"}, {"i": "MetaCyc:R308-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113402", "l": "Formation of DSIF:NELF:early elongation complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21826", "l": "L-glutamate + oxaloacetate => 2-oxoglutarate + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15524", "l": "N-terminal glycyl-[protein] + tetradecanoyl-CoA <=> CoA + H(+) + N-tetradecanoylglycyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29060", "l": "2 H(+)(in) + H2 + ubiquinone-8 => 2 H(+)(out) + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102418", "l": "luteolin-7-O-glucoside 1,6-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-13801"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51514", "l": "NH4(+) + oxalate => H2O + oxamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017096", "l": "acetylserotonin O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10890", "l": "4-carboxy-2-hydroxy-cis,cis-muconate + 2 H(+) + NADPH => 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209840", "l": "Two DITs combine to form thyroxine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694551", "l": "3CLp cleaves nsp6-11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53165", "l": "H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59136", "l": "ATP + citrate + D-ornithine = AMP + diphosphate + H(+) + N(5)-[(S)-citryl]-D-ornithine"}, {"i": "EC:6.3.2.58", "l": "\"D-ornithine--citrate ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654404", "l": "Activated FGFR2 binds SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983427", "l": "Expression of peptide bound class I MHC on cell surface (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112395", "l": "Abortive termination of elongation after arrest (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39108", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate => (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008475", "l": "procollagen-lysine 5-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64244", "l": "a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855111", "l": "VLDLR binds PCSK9 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004441", "l": "inositol-1,4-bisphosphate 1-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18858", "l": "lithocholate + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxylithocholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20751", "l": "2-oxoglutarate + O2 + penicillin N <=> CO2 + deacetoxycephalosporin C + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5618331", "l": "HDAC6 deacetylates microtubules (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20847", "l": "ATP + hydrogencarbonate + pyruvate <=> ADP + H(+) + oxaloacetate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47134", "l": "11-cis-retinoate + 2 H(+) + NADH => 11-cis-retinal + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12053", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + trichodiene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21183", "l": "1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol <=> D-glucose + indole-3-acetyl-1D-myo-inositol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55245", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10580", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + ATP + L-glutamate = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n+1 + ADP + H(+) + phosphate"}, {"i": "EC:6.3.2.17", "l": "\"Tetrahydrofolate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.88"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610723", "l": "GLI proteins bind SUFU (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0016597", "l": "amino acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38332", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4086200", "l": "Dentin matrix protein 1 binds integrin alphaVbeta3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548890", "l": "Removal of the third glucose by glucosidase II and release from the chaperone (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008983", "l": "protein-glutamate O-methyltransferase activity"}, {"i": "MetaCyc:CHER-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24942", "l": "(R)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+) <=> D-glutamate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5336184", "l": "GPR37L binds prosaposin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35061", "l": "chloramphenicol(out) + H(+)(in) => chloramphenicol(in) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14821", "l": "L-arabinose = L-ribulose"}, {"i": "EC:5.3.1.4", "l": "\"L-arabinose isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810159", "l": "HOXB2 chromatin is activated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61863", "l": "dehydroprobetaenone I + H(+) + NADPH + O2 <=> epoxybetaenone + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877941", "l": "RUNX2 binds SMAD1 in the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396234", "l": "Collagen type VII binds laminin-322 and collagen IV (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3149519", "l": "MMACHC decyanates CNCbl (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205238", "l": "SHP2 interacts with p-KIT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113451", "l": "Resumption of RNA Polymerase III Productive Transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21186", "l": "dolichyl beta-D-mannosyl phosphate + GDP => dolichyl phosphate + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32586", "l": "dihydrocarvone + H(+) + NADPH + O2 <=> 6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63899", "l": "aspulvinone E + hnu <=> isoaspulvinone E"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17952", "l": "3-hydroxy-1H-quinolin-4-one + O2 <=> CO + H(+) + N-formylanthranilate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15156", "l": "4-hydroxybenzoate + UDP-alpha-D-glucose <=> 4-(beta-D-glucosyloxy)benzoate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48785", "l": "D-erythrulose 4-phosphate => D-erythrose 4-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805205", "l": "GPR35 binds kynurenic acid (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59253", "l": "(E)-3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate => (E)-3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32648", "l": "erythromycin C + S-adenosyl-L-methionine => erythromycin A + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38091", "l": "delta-tocotrienol + S-adenosyl-L-methionine = beta-tocotrienol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25099", "l": "ATP + UDP => ADP + UTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57441", "l": "2-methylanisole + O2 + reduced [NADH--hemoprotein reductase] => 2-hydroxytoluene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672973", "l": "MAP2Ks phosphorylate MAPKs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32502", "l": "(1R,5R)-sabinene + H(+) + NADPH + O2 <=> (1S,3R,5S)-sabinol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654603", "l": "Activated FGFR2 binds FRS3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45240", "l": "a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA"}, {"i": "EC:5.3.3.21", "l": "\"Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31328", "l": "1D-myo-inositol 3-phosphate + CDP-1L-myo-inositol => bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803761", "l": "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16005", "l": "galactarate = 5-dehydro-4-deoxy-D-glucarate + H2O"}, {"i": "EC:4.2.1.42", "l": "\"Galactarate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193812", "l": "Efflux of 27-hydroxycholesterol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853315", "l": "Activated FGFR3 fusions phosphorylate FRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59214", "l": "AMP + H(+) + octadecanoyl-[(hydroxy)phthioceranic acid synthase] => holo-[(hydroxy)phthioceranic acid synthase] + octadecanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.65", "l": "\"Thermomycolin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189406", "l": "4 PBGs bind to form HMB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0030548", "l": "acetylcholine receptor regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34122", "l": "3 H(+) + hexanoyl-CoA + 3 malonyl-CoA <=> 3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047033", "l": "15-hydroxyprostaglandin-I dehydrogenase (NADP+) activity"}, {"i": "KEGG.REACTION:R03520"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12645", "l": "CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + S-2-(indol-3-yl)acetyl-CoA"}, {"i": "EC:1.2.7.8", "l": "\"Indolepyruvate ferredoxin oxidoreductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19901", "l": "L-tryptophan + O2 = alpha,beta-didehydrotryptophan + H2O2"}, {"i": "EC:1.3.3.10", "l": "\"Tryptophan alpha,beta-oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29118", "l": "H(+) + menaquinone-8 + NADPH <=> menaquinol-8 + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050110", "l": "mucinaminylserine mucinaminidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57851", "l": "2-oxoglutarate + O2 + scopoletin <=> CO2 + fraxetin + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612243", "l": "APOE gene transcription is stimulated by ERBB4s80 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28487", "l": "Fe(2+)(in) => Fe(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44681", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58905", "l": "8 (S)-methylmalonyl-CoA + 24 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH => C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28172", "l": "butan-2-one + hydrogen cyanide => (2R)-2-hydroxy-2-methylbutanenitrile"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44553", "l": "1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O => H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28717", "l": "(R)-malate(out) + 2 H(+)(out) => (R)-malate(in) + 2 H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20489", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala)"}, {"i": "EC:2.3.2.11", "l": "\"Alanylphosphatidylglycerol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49176", "l": "12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine = 12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.153", "l": "\"Adenosine tuberculosinyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047582", "l": "4-methyleneglutaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39932", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38757", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008696", "l": "IL37(?-218) translocates from the cytosol to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37756", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391941", "l": "BLT receptors can bind LTB4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55191", "l": "5-methyluridine(54) in tRNA + ATP + hydrogen sulfide <=> 5-methyl-2-thiouridine(54) in tRNA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9651280", "l": "RAS GAP mutants aren't stimulated by GAPs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102906", "l": "7-epi-alpha-selinene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50456", "l": "prostaglandin H3 = prostaglandin D3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63568", "l": "beta-casomorphin-7 + H2O = beta-casomorphin-6 + L-isoleucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59422", "l": "formaldehyde + H2O2 + NH4(+) => H2O + methylamine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56618", "l": "1,2,4-trichlorobenzene + chloride + H(+) => (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41228", "l": "(S)-4-hydroxymandelate + O2 => 4-hydroxyphenylglyoxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990028", "l": "intermediate voltage-gated calcium channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.141"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10086", "l": "3-carboxy-cis,cis-muconate + 2 H(+) => 3,4-dihydroxybenzoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11504", "l": "6-demethylsterigmatocystin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + sterigmatocystin"}, {"i": "EC:2.1.1.109", "l": "\"Demethylsterigmatocystin 6-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52161", "l": "(E)-phenylacetaldehyde oxime => (Z)-phenylacetaldehyde oxime"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47750", "l": "a ubiquinol + n Na(+)(out) + NAD(+) => a ubiquinone + H(+) + n Na(+)(in) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64820", "l": "2-phenylacetamide + H2O = 2-phenylacetate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22272", "l": "(20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase] = (20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.121", "l": "\"Protopanaxadiol 6-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483186", "l": "PC is converted to PS by PTDSS1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42970", "l": "2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(56) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939335", "l": "RNF181 polyubiquinates BCL10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682826", "l": "LGI1 binds ADAM11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023980", "l": "18(S)-RvE1, E2 and E3 translocate from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717182", "l": "L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding TAS1R1:TAS1R3:L-Glu,L-Asp:GMP,IMP and GNAT3:GTP, and GNB1,3:GNG13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913451", "l": "IL3RB is phosphorylated on Ser-585 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614460", "l": "Dimerization of procollagen type VI (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031842", "l": "type 1 neuropeptide Y receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609310", "l": "β-blockers bind ADRB1,2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110311", "l": "POLZ extends translesion synthesis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018573", "l": "NOTCH3 binds activated EGFR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49174", "l": "12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine => 8,12-diethyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64736", "l": "4-hydroxynonanal + NADP(+) = (E)-4-hydroxynon-2-enal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59195", "l": "ATP + eicosanoate + H(+) <=> diphosphate + icosanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45852", "l": "Co(II)-factor III + H(+) + S-adenosyl-L-methionine = Co(II)-factor IV + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811431", "l": "RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.8", "l": "\"Muramoylpentapeptide carboxypeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6789092", "l": "NOX2 generates superoxide anion from oxygen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213195", "l": "Formation of anchoring fibrils (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5615668", "l": "AKR1C3 reduces atRAL to atROL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480509", "l": "Expression of EPHA1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44498", "l": "2-(acylamino)ethyl fatty acid + a monoacyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21875", "l": "L-arginyl-[cytochrome c] + S-adenosyl-L-methionine <=> H(+) + N(omega)-methyl-L-arginyl-[cytochrome c] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37772", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043559", "l": "insulin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947531", "l": "Molybdenum ion transfer onto molybdopterin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40704", "l": "(9Z,12Z)-octadecadien-1-ol + 1-hexadecanoylglycerone 3-phosphate => 1-O-(9Z,12Z)-octadecadienylglycerone 3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25961", "l": "benzoin + NADP(+) => benzil + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0140328", "l": "floppase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132061", "l": "Complement factor B binds to surface-bound C3b fragment (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57980", "l": "(20S)-protopanaxatriol + UDP-alpha-D-glucose = (20S)-ginsenoside F1 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56062", "l": "CO2 + pentadecane => H(+) + hexadecanoate + hnu"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047158", "l": "sinapoylglucose-sinapoylglucose O-sinapoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44172", "l": "H2O + NAD(+) + tetradecanal = 2 H(+) + NADH + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388833", "l": "Phosphorylation of CTLA-4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30711", "l": "(S)-linalool = beta-myrcene + H2O"}, {"i": "EC:4.2.1.127", "l": "\"Linalool dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31566", "l": "H2O + leukotriene C4 <=> L-glutamate + leukotriene D4"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061775", "l": "cohesin loading activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57667", "l": "(+)-valencene + O2 + reduced [NADPH--hemoprotein reductase] <=> alpha-nootkatol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626981", "l": "TNF-alpha:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449087", "l": "CD4 binds Interleukin-16 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015195", "l": "L-threonine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427514", "l": "eNoSC deacetylates histone H3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25119", "l": "(S)-2-amino-6-oxohexanoate + H(+) + NADH + NH4(+) => H2O + L-lysine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30838", "l": "H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose <=> NADP(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418904", "l": "A1 and A3 receptors bind adenosine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15208", "l": "a dolichyl diphosphooligosaccharide + H2O <=> an oligosaccharide-(1->4)-N-acetyl-beta-D-glucosamine-(1->4)-N-acetyl-alpha-D-glucosamine 1-phosphate + dolichyl phosphate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879594", "l": "SLCO4C1 mediates the transport of digoxin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4332359", "l": "Active calmodulin binds CAMK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52410", "l": "CO2 + dihydroxyacetone phosphate + NADH => 4-phospho-D-erythronate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43669", "l": "ATP + hexacosanoyl-CoA + hydrogencarbonate => 2-carboxyhexacosanoyl-CoA + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13870", "l": "NAD(+) + prephenate => 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62040", "l": "H2O + N-(octanoyl)-sphing-4-enine-1-phosphate = N-octanoylsphing-4-enine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62108", "l": "an acyl-CoA + sn-glycero-3-phosphoethanolamine = a monoacyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53059", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> H(+) + isowyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000411", "l": "RANBP2 SUMOylates PML with SUMO2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50267", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 26-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39053", "l": "ADP + cholesterol(out) + H(+) + phosphate => ATP + cholesterol(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693125", "l": "RHOF binds effectors at the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047560", "l": "3-dehydrosphinganine reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20248", "l": "ATP + streptomycin <=> 3''-O-adenylylstreptomycin + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33311", "l": "2 A + hydroxylamine + NH4(+) = 2 AH2 + H(+) + H2O + N2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.4.7", "l": "\"Hydroperoxy icosatetraenoate isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33411", "l": "(S)-malyl N-acetyl-alpha-D-glucosaminide + H2O = (S)-malyl alpha-D-glucosaminide + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928591", "l": "EPH:EFN tetramers oligomerise (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043796", "l": "glyceraldehyde dehydrogenase (NADP) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37665", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP => 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18108", "l": "ATP + Ca(2+)(in) + H2O <=> ADP + Ca(2+)(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700171", "l": "Active ALK phosphorylates PLCG1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65945", "l": "AH2 + CTP + S-adenosyl-L-methionine => 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990600", "l": "single-stranded DNA endodeoxyribonuclease activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391372", "l": "GNRHR binds GNRH1,2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54964", "l": "hexadecanoyl-[ACP] + phosphate = hexadecanoyl phosphate + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58131", "l": "A + O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine <=> AH2 + alstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64909", "l": "CTP + 2 H2O => CMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53982", "l": "(11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417896", "l": "P2Y6 receptor can bind to UDP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420265", "l": "AMY1-3 bind IAPP(34-70) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54267", "l": "2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2 <=> (3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21714", "l": "benzaldehyde + glycine => L-threo-3-phenylserine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14291", "l": "AMP + diphosphate + omega-dicarboxyl-CoA => a dicarboxylate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0008443", "l": "phosphofructokinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39472", "l": "(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0008253", "l": "5'-nucleotidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "80.661393760018115", "identifiers": [{"i": "GO:0001098", "l": "basal transcription machinery binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9658253", "l": "RAS:GTP binds PI3K (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23451", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP <=> CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41318", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050107", "l": "monoterpenol O-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33219", "l": "ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = gibberellin A12 + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.107", "l": "\"Ent-kaurenoic acid monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-203567", "l": "palmitoylation of eNOS (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53447", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 11beta,17beta-dihydroxyandrost-4-ene-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34629", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + H2O + 2 oxidized [adrenodoxin] => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62803", "l": "2 7-demethylsiderin + NADPH + O2 <=> 2 H2O + NADP(+) + orlandin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60669", "l": "(R,R)-chrysanthemol + NAD(+) => (1R,3R)-chrysanthemal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23444", "l": "(S)-lactate + NAD(+) = H(+) + NADH + pyruvate"}, {"i": "EC:1.1.1.27", "l": "\"L-lactate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43349", "l": "cholesteryl (9Z-octadecenoate)(in) => cholesteryl (9Z-octadecenoate)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13156", "l": "(R)-glycerate + CO2 + NAD(+) <=> 2-hydroxy-3-oxosuccinate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372980", "l": "succinylCoA + GDP + Pi <=> succinate + CoASH + GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191654", "l": "c-src associates with Cx43 in gap junctions (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60157", "l": "ATP + D-galactose(out) + H2O => ADP + D-galactose(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805638", "l": "KAT6A acetylates TP53 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204861", "l": "Interaction of Tie2 and Shc1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56764", "l": "12-epi-fischerindole U + 2-oxoglutarate + chloride + H(+) + O2 = 12-epi-fischerindole G + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35363", "l": "(2E)-13-methyltetradecenoyl-CoA + H(+) + NADPH = isopentadecanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034779", "l": "4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53190", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine => 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63809", "l": "ATP + citrate + spermidine => AMP + diphosphate + H(+) + N(8)-citryl-spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654511", "l": "FGFRL1 dimer binds FGFs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25982", "l": "albaflavenone + 2 H2O + NADP(+) => (5S)-albaflavenol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38733", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28823", "l": "H(+)(in) + L-galactonate(in) = H(+)(out) + L-galactonate(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102194", "l": "protein-fructosamine 3-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1445144", "l": "p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371591", "l": "Trimerization of cytosolic HSF1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163320", "l": "Association of mTERF with the termination sequence (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050347", "l": "trans-octaprenyltranstransferase activity"}, {"i": "RHEA:11324", "l": "all-trans-octaprenyl diphosphate + isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + diphosphate"}, {"i": "KEGG.REACTION:R07267"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29490", "l": "(2E,6E)-farnesyl diphosphate <=> cis-muurola-3,5-diene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21825", "l": "2-oxoglutarate + L-aspartate => L-glutamate + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9641111", "l": "Parkin transfers Ub to misfolded proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112690", "l": "PTPN11 binds CBL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46117", "l": "2-dehydro-3-deoxy-D-galactonate => D-glyceraldehyde + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54293", "l": "ATP + L-threonyl-[protein] => 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64419", "l": "D-xylofuranose + NADP(+) <=> D-xylono-1,4-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50440", "l": "prostaglandin H1 = prostaglandin D1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35916", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.70"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66484", "l": "16alpha-hydroxygypsogenate + UDP-alpha-D-glucose = 16alpha-hydroxygypsogenate 28-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.59", "l": "\"Tryptophan 6-halogenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050210", "l": "prenyl-diphosphatase activity"}, {"i": "RHEA:21496", "l": "dimethylallyl diphosphate + H2O = diphosphate + prenol"}, {"i": "EC:3.1.7.1", "l": "\"Prenyl-diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10352", "l": "an N-acetylarylalkylamine + H2O = acetate + an arylalkylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27474", "l": "ATP + D-glycero-beta-D-manno-heptose 7-phosphate => ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52224", "l": "3 AH2 + 3 H(+) + heme b + 3 O2 = 3 A + biliverdin delta + CO + Fe(2+) + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25751", "l": "N-hydroxy-L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56079", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640195", "l": "RRAGA,B hydrolyzes GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0008318", "l": "protein prenyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001972", "l": "retinoic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44347", "l": "ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide A + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948066", "l": "K63polyUb-IRAK1 dissociates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53077", "l": "cytidine(34) in mitochondrial tRNA + S-adenosyl-L-methionine => 5-methylcytidine(34) in mitochondrial tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358791", "l": "Phosphorylation of USP8 by P-AKT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66991", "l": "4-methylpentanoate + ATP + CoA <=> 4-methylpentanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9649735", "l": "Intrinsic nucleotide exchange on RAS (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454208", "l": "Phosphorylation of beta and gamma subunits by LYN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607722", "l": "Active NIK phosphorylates IKKA dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.96"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805620", "l": "KAT6A and PML bind TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50933", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 => (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66096", "l": "3-phenylpyruvate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351901", "l": "Caspase-mediated cleavage of MST3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008446", "l": "GDP-mannose 4,6-dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56215", "l": "O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607747", "l": "TRAF6 binds MALT1 oligomers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9007901", "l": "IL1F10 binds IL1RL2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189062", "l": "lactose + H2O => D-glucose + D-galactose (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008109", "l": "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51608", "l": "(R)-2-hydroxyglutarate + pyruvate = (R)-lactate + 2-oxoglutarate"}, {"i": "RHEA:51612", "l": "(R)-2-hydroxyglutarate + oxaloacetate = (R)-malate + 2-oxoglutarate"}, {"i": "EC:1.1.99.40", "l": "\"(R)-2-hydroxyglutarate--pyruvate transhydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59382", "l": "3-(4-aminophenyl)pyruvate + CO2 + H(+) + NADH => 4-amino-4-deoxyprephenate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32538", "l": "(2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O <=> 4-hydroxy-2-oxohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16557", "l": "2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2-aminomuconate 6-semialdehyde + CO2"}, {"i": "EC:4.1.1.45", "l": "\"Aminocarboxymuconate-semialdehyde decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63713", "l": "2 [Fe(II)-cytochrome b5] + a (7Z,10Z,13Z,16Z)-docosatetraenoyl derivative + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl derivative + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21571", "l": "beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O <=> beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240782", "l": "E2F1/2/3 stimulates EED transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161735", "l": "PGC2 is isomerised to PGB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850818", "l": "SPINK9 binds KLK5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390846", "l": "D2D3,4 bind to DA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48850", "l": "13-hydroperoxy-(9Z,11E)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-434989", "l": "SEMA7A binds to PLXNC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428752", "l": "Dissociation of the TP:Gq complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392751", "l": "L1 linked to actin cytoskeleton by ankyrin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17634", "l": "a beta-D-glucuronoside + H2O => an alcohol + D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39308", "l": "(2E,11Z,14Z)-eicosatrienoyl-CoA + H(+) + NADPH => (11Z,14Z)-eicosadienoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683735", "l": "CHEK2 is recruited to DNA DSBs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070226", "l": "sulfur:ferric ion oxidoreductase activity"}, {"i": "MetaCyc:SULFFEOXIDO-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57669", "l": "alpha-nootkatol + O2 + reduced [NADPH--hemoprotein reductase] => (+)-nootkatone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047967", "l": "glycyrrhizinate beta-glucuronidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37472", "l": "3-methylbutanoyl-CoA + S-adenosyl-L-methionine => CoA + H(+) + N-isovaleryl-L-homoserine lactone + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62491", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183055", "l": "Binding of CBL to EGFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29778", "l": "alpha-D-ribose 1-phosphate + ATP <=> ADP + alpha-D-ribose 1,5-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52682", "l": "CoA + H(+) + N-acetyl-L-alpha-phenylglycine => acetyl-CoA + L-alpha-phenylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420265", "l": "AMY1-3 bind IAPP(34-70) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102857", "l": "1-18:1-2-18:3-phosphatidylcholinedesaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44747", "l": "4 H(+) + 4 malonyl-CoA <=> (3,5-dihydroxyphenyl)acetyl-CoA + 4 CO2 + 3 CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434650", "l": "MATEs mediate extrusion of xenobiotics (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23496", "l": "5-hydroxypentanoate + acetyl-CoA = 5-hydroxy-pentanoyl-CoA + acetate"}, {"i": "EC:2.8.3.14", "l": "\"5-hydroxypentanoate CoA-transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59818", "l": "a sterol ester + CoA => a long-chain fatty acyl-CoA + a sterol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102928", "l": "beta-solanine rhamnosyltransferase activity"}, {"i": "MetaCyc:RXN-8884"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.200"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65689", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(38-hydroxyoctatriacontenoyl)-sphing-4-enine => a diacylglycerol + an N-(38-(9Z,12Z-octadecadienoyloxy)-octatriacontenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34940", "l": "H2O + menaquinone-8 + selenite => menaquinol-8 + selenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55109", "l": "3-oxononanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxynonanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11760", "l": "4 ATP + citrate + 2 H2O + 2 N(6)-acetyl-N(6)-hydroxy-L-lysine = 4 ADP + aerobactin + 4 H(+) + 4 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41436", "l": "(9Z)-octadecenoyl-CoA + cholesterol = cholesteryl (9Z-octadecenoate) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12192", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate"}, {"i": "EC:4.2.3.166", "l": "\"(+)-(1(10)E,4E,6S,7R)-germacradien-6-ol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70971", "l": "citrate <=> isocitrate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876868", "l": "ECE1 cleaves EDN1(53-90) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59719", "l": "D-maltopentaono-1,5-lactone + H2O <=> D-maltopentaonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15472", "l": "1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide <=> 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46958", "l": "(E)-caffeoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => hydrocaffeoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31680", "l": "O2 + prosolanapyrone II => H2O2 + prosolanapyrone III"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14751", "l": "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(+) => 1-hydroxy-2-naphthoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668714", "l": "RAC1:GTP binds NOX1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11794", "l": "1,2-epoxypropane + H2O + NAD(+) => H(+) + NADH + O2 + propene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222583", "l": "MscR reduces nitrosomycothiol to ammonia (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46393", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 4beta,24S-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010951", "l": "ROBO1 binds NRP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209271", "l": "N-HH moves from the cytosol to the extracellular region (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30037", "l": "benzene-1,2,4-triol + CO2 + H2O + NAD(+) => 3,4-dihydroxybenzoate + 2 H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45269", "l": "4'-hydroxyechinenone + AH2 + O2 => 4',4'-dihydroxyechinenone + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389083", "l": "Autophosphorylation of PDGF alpha receptors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19033", "l": "an N-acyl-D-glucosamine = an N-acyl-D-mannosamine"}, {"i": "EC:5.1.3.8", "l": "\"N-acylglucosamine 2-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421201", "l": "inosine 5'-monophosphate (IMP) + L-aspartate + GTP => adenylosuccinate + GDP + orthophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23094", "l": "ethylamine + N-isopropylammelide => H(+) + H2O + hydroxyatrazine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62370", "l": "Fe(2+)(in) + 2 hydrogencarbonate(in) => Fe(2+)(out) + 2 hydrogencarbonate(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034879", "l": "2,3,6-trihydroxyisonicotinate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26426", "l": "ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate"}, {"i": "EC:6.3.4.2", "l": "\"CTP synthase (glutamine hydrolyzing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19476", "l": "4-hydroxybenzoate + H(+) + NADH + O2 <=> 3,4-dihydroxybenzoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64758", "l": "benzylthiol + NH4(+) + pyruvate => H2O + S-benzyl-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33152", "l": "(R)-dihydrolipoamide + acetyl-CoA => (R)-S(6)-acetyldihydrolipoamide + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877902", "l": "Activated AR binds RUNX2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696266", "l": "RND2 binds effectors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57810", "l": "3-chlorocatechol + NAD(+) + nitrite => 1-chloro-3-nitrobenzene + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3149539", "l": "MTR transfers CH3 group from MTHF to cob(I)alamin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62466", "l": "2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950456", "l": "IL12B dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854466", "l": "VLDLR binds RELN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34359", "l": "a 1,2-diacylglycerol + H2O = a 2-acylglycerol + a carboxylate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60505", "l": "1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65370", "l": "a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64906", "l": "GMP + 2 H(+) + 2 phosphate => GTP + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63475", "l": "all-trans-hexaprenol + ATP <=> ADP + all-trans-hexaprenyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0030159", "l": "signaling receptor complex adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20606", "l": "cytosine + H(+) + H2O => NH4(+) + uracil"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805507", "l": "APAF1 binds AVEN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879930", "l": "STAT5 is recruited by JAK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688294", "l": "SIRT5 deacetylates Cytochrome C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621035", "l": "EGR1 binds the TF gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9687638", "l": "MLKL binds IP4, IP5 and IP6  (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27271", "l": "CoA + hexadecanal + NADP(+) => H(+) + hexadecanoyl-CoA + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "81.20444558259193", "identifiers": [{"i": "GO:0016274", "l": "protein-arginine N-methyltransferase activity"}, {"i": "REACT:R-HSA-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-195304", "l": "Association of beta-catenin with the destruction complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11259", "l": "H2O + limonin + UDP-alpha-D-glucose <=> glucosyl-limonin + 2 H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46846", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15554", "l": "1D-myo-inositol 1,4-bisphosphate + H2O => 1D-myo-inositol 4-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54384", "l": "a 3-oxo-5alpha-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + H(+) + NADPH"}, {"i": "EC:1.3.1.22", "l": "\"3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009032", "l": "thymidine phosphorylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53835", "l": "2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 <=> a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39595", "l": "(2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H(+) + NADPH = (10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177694", "l": "Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168400", "l": "iE-DAP elicits a NOD1 response (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814094", "l": "ARL1:GTP binds ARFIP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676595", "l": "TRAFs bind RANK:RANKL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10536", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate"}, {"i": "EC:3.1.6.10", "l": "\"Chondro-6-sulfatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392513", "l": "Rap1 signal termination by Rap1GAPs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.37"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36758", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose <=> beta-D-Glc-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13247", "l": "glyoxylate + succinate => D-threo-isocitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5223313", "l": "ABCD4:LMBRD1 transports Cbl from lysosomal lumen to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948034", "l": "FGR binds LDL:LRP8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11036", "l": "ATP + H2O + quaternary ammonium(out) = ADP + H(+) + phosphate + quaternary ammonium(in)"}, {"i": "EC:7.6.2.9", "l": "\"ABC-type quaternary amine transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674095", "l": "PDGFRs bind type II TKI (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36276", "l": "H(+) + NADPH + O2 + theophylline => 3-methylxanthine + formaldehyde + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38173", "l": "2-hydroxyhexadecyl hexadecanoate + CoA => hexadecane-1,2-diol + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050239", "l": "pyrithiamine deaminase activity"}, {"i": "MetaCyc:PYRITHIAMIN-DEAMINASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19289", "l": "H2O + sucrose 6(F)-phosphate = phosphate + sucrose"}, {"i": "EC:3.1.3.24", "l": "\"Sucrose-phosphate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-213406", "l": "Disassociation of PLC-gamma1 from LAT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51288", "l": "(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate = (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30493", "l": "2 H(+) + H2O + N-hydroxy-L-valine + oxidized [NADPH--hemoprotein reductase] => L-valine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31439", "l": "(2E,6E)-farnesyl diphosphate = alpha-longipinene + diphosphate"}, {"i": "EC:4.2.3.80", "l": "\"Alpha-longipinene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31698", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29345", "l": "L-aspartate(out) + succinate(in) => L-aspartate(in) + succinate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59738", "l": "CoA + S-tetradecanoyl-L-cysteinyl-[protein] => L-cysteinyl-[protein] + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37987", "l": "delta-tocopherol = 2-methyl-6-phytyl-1,4-benzene-1,4-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48071", "l": "ganglioside GM2 (d18:1(4E)) + H2O <=> ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8934742", "l": "RUNX1 binds PRMT1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18501", "l": "ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) + NADPH"}, {"i": "EC:1.3.1.71", "l": "\"Delta(24(24(1)))-sterol reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3301345", "l": "Elongator complex acetylates replicative histone H3, H4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052679", "l": "terpentetriene synthase activity"}, {"i": "MetaCyc:RXN-9455"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944242", "l": "Association of procollagen type XXVII (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40887", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + octadecanoate + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45657", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+) => 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013158", "l": "CDC42 GDIs block activation of CDC42 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64730", "l": "(7S,17S)-dihydroperoxy-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoate => (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2002440", "l": "Removal of fibrillar collagen C-propeptides (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61392", "l": "ATP + N(6)-(D-psicosyl)-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein]"}, {"i": "EC:2.7.1.172", "l": "\"Protein-ribulosamine 3-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433506", "l": "Phosphorylation of APS (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047697", "l": "beta-alanopine dehydrogenase activity"}, {"i": "RHEA:21684", "l": "(R)-beta-alanopine + H2O + NAD(+) = beta-alanine + H(+) + NADH + pyruvate"}, {"i": "EC:1.5.1.26", "l": "\"Beta-alanopine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43553", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381608", "l": "cAMP activates EPAC2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444191", "l": "GPR120 is a receptor for unsaturated long-chain free fatty acids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653974", "l": "Ragulator binds Rag dimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196417", "l": "Reduction of desmosterol to cholesterol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937792", "l": "RUNX3 binds SRC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51868", "l": "dimethylallyl diphosphate + umbelliferone = demethylsuberosin + diphosphate"}, {"i": "RHEA:51872", "l": "dimethylallyl diphosphate + umbelliferone = diphosphate + osthenol"}, {"i": "EC:2.5.1.139", "l": "\"Umbelliferone 6-dimethylallyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20507", "l": "5-oxo-L-proline + an L-alpha-amino acid => an alpha-(gamma-L-glutamyl)-L-amino acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59297", "l": "an N-acylglycine + 2 L-ascorbate + O2 => an N-acyl-(2S)-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109701", "l": "PDPK1 binds PIP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35559", "l": "H(+) + menaquinone-7 + NADH = menaquinol-7 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46978", "l": "6-hydroxy-N-methylmyosmine + H2O2 => (S)-6-hydroxynicotine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982617", "l": "CYGB:O2 dissociates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712195", "l": "ANO2 dimer binds Ca2+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1299338", "l": "Activation of TRESK (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66447", "l": "hexan-3-one + NADP(+) <=> (E)-4-hexen-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73596", "l": "dCMP + H2O => dUMP + NH4+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2889070", "l": "SLC9B2 exchanges Na+, Li+ for H+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59671", "l": "D-cellohexaose + O2 <=> D-cellohexaono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21627", "l": "FMNH2 + NADP(+) <=> FMN + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51711", "l": "D-altritol + NAD(+) <=> H(+) + keto-D-tagatose + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23449", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP => CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38410", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O <=> (9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362522", "l": "ALDHs oxidise atRAL to atRA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4332359", "l": "Active calmodulin binds CAMK2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46230", "l": "adenosine 3',5'-bisphosphate + H(+) + holo-[peptidyl-carrier protein] => apo-[peptidyl-carrier protein] + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867047", "l": "PTPN3 dephosphorylates EPS15 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635102", "l": "GPR161 is internalized (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11169", "l": "3-hydroxy-6-carboxyhexanoyl-CoA + NAD(+) => 3-oxo-6-carboxyhexanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16572", "l": "2-oxoglutarate + L-lysyl-[collagen] + O2 <=> (5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25977", "l": "(+)-epi-isozizaene + H(+) + NADPH + O2 => (5S)-albaflavenol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11520", "l": "(-)-menthol + UDP-alpha-D-glucose = (-)-menthyl beta-D-glucoside + H(+) + UDP"}, {"i": "EC:2.4.1.127", "l": "\"Monoterpenol beta-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61765", "l": "stevioside + UDP-alpha-D-glucose => H(+) + rebaudioside E + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004594", "l": "pantothenate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168638", "l": "Activated IKK phosphorylates I-kappaB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68826", "l": "Free CDT1 associates with CDC6:ORC:origin complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5628871", "l": "BRD7 promotes EP300-mediated acetylation of TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29644", "l": "alpha-maltoheptaose + H2O => alpha-D-glucose + alpha-maltohexaose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373741", "l": "SDK2 homophillic interaction (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.28", "l": "\"S-methyl-5'-thioadenosine phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64794", "l": "2 H(+) + L-1-piperideine-6-carboxylate + NADPH + NH4(+) => L-lysine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20174", "l": "H(+) + NADH + O2 + tetradecanoyl-CoA => (11E)-tetradecenoyl-CoA + 2 H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25578", "l": "3 H2O2 + protoporphyrin IX => 3 O2 + protoporphyrinogen IX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204863", "l": "Interaction of Tie2 with Ang2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29701", "l": "dimethyl sulfoxide(out) => dimethyl sulfoxide(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35116", "l": "4-coumaroyl-CoA + H(+) + malonyl-CoA => (4-coumaroyl)acetyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49082", "l": "dibenzothiophene 5,5-dioxide + FMN + H(+) + H2O => dibenzothiophene 5-oxide + FMNH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22100", "l": "3,5-dibromo-4-hydroxybenzonitrile + 2 H2O = 3,5-dibromo-4-hydroxybenzoate + NH4(+)"}, {"i": "EC:3.5.5.6", "l": "\"Bromoxynil nitrilase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043890", "l": "N-acetylgalactosamine-6-sulfatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791167", "l": "Expression of SERP1 (RAMP4) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33555", "l": "an N-acyl-(4R)-4-hydroxysphinganine + H2O = (4R)-hydroxysphinganine + a fatty acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42829", "l": "2-hydroxy-5-methyl-1-naphthoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2,7-dihydroxy-5-methyl-1-naphthoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917730", "l": "Cargo Recognition And Sorting (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29142", "l": "2 H(+)(in) + menaquinol-8 + nitrate <=> 2 H(+)(out) + H2O + menaquinone-8 + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602170", "l": "CYP27A1 does not 27-hydroxylate 5bCHOL3a,7a,12a-triol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191299", "l": "Squalene is oxidized to its epoxide (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41581", "l": "5,10-dihydrophenazine 1-carboxylate + dimethylallyl diphosphate => 5,10-dihydro-9-dimethylallylphenazine 1-carboxylate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928597", "l": "EPH:EFN dimers tetramerise (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008288", "l": "boss receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14507", "l": "glutathione disulfide + 2 H(+) + hydrogen sulfide + sulfite => 2 glutathione + thiosulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18392", "l": "alpha-D-xylose 1-phosphate + H(+) + UTP <=> diphosphate + UDP-alpha-D-xylose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396594", "l": "Phosphorylation of SLP-76 by p-SYK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211387", "l": "Anthrax lef cleaves target cell MAP2K7 (MEK7) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014456", "l": "GDIs block activation of RHOG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428127", "l": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29793", "l": "ADP + glutathione(in) + H(+) + phosphate => ATP + glutathione(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16168", "l": "L-tryptophan + O2 <=> CO2 + H2O + indole-3-acetamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9704408", "l": "Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429683", "l": "CERT:ceramide [ER] => ceramide [Golgi] + CERT [ER] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41959", "l": "2',3'-cyclic CMP + H2O <=> cytidine 2'-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.395", "l": "\"3-alpha-hydroxybile acid CoA 3-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29353", "l": "Zn(2+)(out) => Zn(2+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390116", "l": "Phospho FT reduces D accumulation at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1299359", "l": "Activation of TALK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45929", "l": "15-hydroxypentadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(16-hydroxy-2-oxohexadecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46732", "l": "(2R,6)-dimethylheptanoyl-CoA = (2S,6)-dimethylheptanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51249", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39989", "l": "all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432148", "l": "Fgr may phosphorylate p38 MAPK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65168", "l": "AH2 + O2 + preaustinoid A = A + H2O + preaustinoid A1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21784", "l": "H2O + L-ascorbate + O2 = 2 H(+) + L-threonate + oxalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20240", "l": "(1S,4S)-5-oxo-1,2-campholide <=> [(1R)-2,2,3-trimethyl-2-oxocyclopent-3-en-1-yl]acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939088", "l": "CR1 gene expression is stimulated by RUNX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672978", "l": "RAF phosphorylates MAP2K dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48625", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + O2 => (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34255", "l": "sporulenol = (R)-tetraprenyl-beta-curcumene + H2O"}, {"i": "EC:4.2.1.137", "l": "\"Sporulenol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222431", "l": "Peroxynitrite is reduced to nitrite by AhpC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21147", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) <=> 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0035514", "l": "DNA demethylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66376", "l": "D-erythrose 4-phosphate + H2O = D-erythrose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213201", "l": "Formation of collagen fibres (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1011598", "l": "DOCKs bind to RhoGEFs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31493", "l": "H(+) + soyasaponin I + UDP => soyasaponin III + UDP-beta-L-rhamnose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21135", "l": "H2O + O2 + xanthine <=> H2O2 + urate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38595", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20800", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53239", "l": "cholesta-5,24-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> cholesta-5,24Z-dien-3beta,27-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33160", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46839", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174097", "l": "Association of Emi1 with Cdh1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12785", "l": "an alditol + NAD(+) = an aldose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174444", "l": "Formation of C-strand Okazaki fragments (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56831", "l": "2,3,6-trichlorohydroquinone + chloride + glutathione disulfide <=> 2,3,5,6-tetrachlorohydroquinone + 2 glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17176", "l": "glutathionylspermidine + H2O <=> glutathione + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961874", "l": "DHFR gene expression is stimulated by E2F1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28078", "l": "2-hydroxyethylphosphonate + NAD(+) = H(+) + NADH + phosphonoacetaldehyde"}, {"i": "EC:1.1.1.309", "l": "\"Phosphonoacetaldehyde reductase (NADH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031981", "l": "NTRK2-phosphorylated FRS2 binds PTPN11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61879", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-8-hydroperoxy-20-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430311", "l": "Rsu-1 interacts with Pinch1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42334", "l": "ADP + H(+) + oxidized coenzyme alpha-F420-3 + phosphate => ATP + L-glutamate + oxidized coenzyme F420-2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45115", "l": "gamma-tocopherol + H(+) + NADPH + O2 <=> 13-hydroxy-gamma-tocopherol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16609", "l": "AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine"}, {"i": "EC:2.4.2.7", "l": "\"Adenine phosphoribosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12108", "l": "L-arginyl-[histone] + S-adenosyl-L-methionine = H(+) + N(omega)-methyl-L-arginyl-[histone] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22300", "l": "a flavonol + UDP-alpha-D-glucose = a flavonol 3-O-beta-D-glucoside + H(+) + UDP"}, {"i": "EC:2.4.1.91", "l": "\"Flavonol 3-O-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948066", "l": "K63polyUb-IRAK1 dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018577", "l": "catechol 2,3-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784436", "l": "An unknown carrier transports mitochondrial glyoxylate to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46225", "l": "(E)-feruloyl-CoA + H2O => (E)-ferulate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465940", "l": "atRAL is reduced to atROL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004306", "l": "ethanolamine-phosphate cytidylyltransferase activity"}, {"i": "RHEA:24592", "l": "CTP + H(+) + phosphoethanolamine = CDP-ethanolamine + diphosphate"}, {"i": "EC:2.7.7.14", "l": "\"Ethanolamine-phosphate cytidylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42681", "l": "2 hercynine + 2 L-selenocysteine + O2 => 2 H2O + 2 hercynylselenocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382553", "l": "ABCA7:Apo1A-mediated phospholipid efflux (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030779", "l": "10-hydroxydihydrosanguinarine 10-O-methyltransferase activity"}, {"i": "KEGG.REACTION:R04707"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362522", "l": "ALDHs oxidise atRAL to atRA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61103", "l": "(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-dihydrotricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19722", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA => (9Z)-octadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32293", "l": "3 H(+) + phosphocholine + 3 S-adenosyl-L-homocysteine => phosphoethanolamine + 3 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55282", "l": "13-cis-retinyl tetradecanoate + CoA => 13-cis-retinol + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.18", "l": "\"1,4-alpha-glucan branching enzyme\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54395", "l": "1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22995", "l": "3-oxopropanoate + CoA + NAD(+) <=> acetyl-CoA + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194800", "l": "botE LC cleaves target cell SNAP25 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080176", "l": "xyloglucan 1,6-alpha-xylosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-947531", "l": "Molybdenum ion transfer onto molybdopterin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62671", "l": "deoxyherqueinone + H(+) + NADPH + O2 <=> H2O + herqueinone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22703", "l": "gibberellin A12 aldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> gibberellin A12 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66155", "l": "acetyl-CoA + noradrenaline <=> CoA + H(+) + N-acetylnoradrenaline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54174", "l": "L-lysyl-[protein] + nicotinamide + O-acyl-ADP-D-ribose => H2O + N(6)-acyl-L-lysyl-[protein] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32018", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-delta-cadinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166041", "l": "Transfer of LPS onto TLR4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19131", "l": "ADP + dTMP + H(+) => ATP + thymidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39293", "l": "3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + CO2 + CoA => (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19601", "l": "H(+) + NADH + O2 + orcinol = 2,3,5-trihydroxytoluene + H2O + NAD(+)"}, {"i": "EC:1.14.13.6", "l": "\"Orcinol 2-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018844", "l": "2-hydroxytetrahydrofuran isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374337", "l": "Apelin receptor binds to apelin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62528", "l": "2 [Fe(II)cytochrome c] + digoxin + 3 H(+) = 2 [Fe(III)cytochrome c] + dihydrodigoxin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44675", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O <=> a 1-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673760", "l": "Ligand-independent dimerization of membrane-tethered fusions of PDGFRA or PDGFRB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932351", "l": "KEAP1 facilitates ubiquitination of NFE2L2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52781", "l": "H2O + S-(hercyn-2-yl)-L-cysteine S-oxide => 2-sulfenohercynine + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20656", "l": "23,24-dihydrocucurbitacin B + NAD(+) <=> cucurbitacin B + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38413", "l": "(9Z,12Z,15Z)-octadecatrienoate + 1,3-di-(9Z,12Z,15Z)-octadecatrienoylglycerol + H(+) => 1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40153", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+) => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202212", "l": "Recruitment of PLC-gamma1 to LAT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018662", "l": "phenol 2-monooxygenase activity"}, {"i": "RHEA:17061", "l": "H(+) + NADPH + O2 + phenol = catechol + H2O + NADP(+)"}, {"i": "EC:1.14.13.7", "l": "\"Phenol 2-monooxygenase (NADPH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672951", "l": "Inactive RAFs bind YWHAB (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134962", "l": "DHX36 binds DNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950113", "l": "IL12A binds IL12B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944263", "l": "Association of procollagen type II (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65476", "l": "1-propanol + butanoyl-CoA = CoA + propyl butanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54685", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (-)-kolavenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2545203", "l": "Deacetylation of cleaved cohesin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592398", "l": "Activation of proMMP8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24989", "l": "(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin] => calcitroate + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22450", "l": "ADP + H(+) + psi-UMP => ATP + pseudouridine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190260", "l": "FGFR2b binds to FGF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.12"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51538", "l": "H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-L-tyrosyl-[protein] + UDP => L-tyrosyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25473", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + gamma-himachalene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928627", "l": "EPHB phosphorylates TIAM1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5622129", "l": "FABP5 binds atRA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35637", "l": "an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucoside + H(+) + UDP => an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204465", "l": "Basigin interacts with CD43 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14781", "l": "ATP + CoA + heptanedioate = 6-carboxyhexanoyl-CoA + AMP + diphosphate"}, {"i": "EC:6.2.1.14", "l": "\"6-carboxyhexanoate--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380586", "l": "loading of Serotonin in synaptic vesicles (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198611", "l": "AKT phosphorylates IKKalpha (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165195", "l": "GTP loading by Rheb (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14207", "l": "anserine + H(+) + S-adenosyl-L-homocysteine => carnosine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41761", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM3 (d18:1(4E)) => CMP + ganglioside GD3 (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57609", "l": "(1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+) => 3-chlorocatechol + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047942", "l": "glutamate-ethylamine ligase activity"}, {"i": "MetaCyc:GLUTAMATE--ETHYLAMINE-LIGASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5628871", "l": "BRD7 promotes EP300-mediated acetylation of TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42838", "l": "5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 4 H2O + 3 NADP(+) => acetyl-CoA + 7 H(+) + 5 malonyl-CoA + 3 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371467", "l": "SIRT1 deacetylates HSF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50448", "l": "AH2 + prostaglandin G3 = A + H2O + prostaglandin H3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791235", "l": "GADD45A binds AURKA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57498", "l": "2-methyl-cis-aconitate + H2O => 2-methylcitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873917", "l": "Translocation of STAT1 dimer to nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.98"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990459", "l": "transferrin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43713", "l": "ATP + dodecanoate + H(+) => diphosphate + dodecanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43212", "l": "adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.230", "l": "\"23S rRNA (adenosine(1067)-2'-O)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34511", "l": "N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine = H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP"}, {"i": "EC:2.4.1.290", "l": "\"N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174967", "l": "NAT2 acetylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707516", "l": "FeHM dissociates from MetHb (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37606", "l": "(11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865454", "l": "CBFB binds RUNX3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097690", "l": "iron ion transmembrane transporter inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16682", "l": "4-hydroxyphenylacetate + H(+) + NADH + O2 => 3,4-dihydroxyphenylacetate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033418", "l": "CUC codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936745", "l": "deacetylation of O-acetylserine and sulfhydrylation using CysK2 (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003990", "l": "acetylcholinesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9690449", "l": "S1PR1 bind S1P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37502", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33843", "l": "H2O + N-tetracosanoylsphinganine = sphinganine + tetracosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41632", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + L-serine = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phospho-L-serine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61073", "l": "(-)-(R)-19-hydroxytabersonine + acetyl-CoA => (-)-(R)-19-O-acetyltabersonine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675194", "l": "Activated MAPK phosphorylates RAF1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75146", "l": "TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676229", "l": "WIPIs bind PI3P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000122", "l": "CD320 transports extracellular TCII:Cbl to endosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634445", "l": "MYC gene expression is enhanced by E2F1, STAT3, and CEBPB and repressed by CEBPA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70613", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445088", "l": "CHL1 interacts with beta1 integrins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36338", "l": "D-glucuronate + H2O + NAD(+) <=> D-glucarate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141341", "l": "SMOX-3 oxidises SPN to SPM (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68611", "l": "Formation of ORC(1-5) complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1564169", "l": "Collagen type VIII degradation by MMP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140585", "l": "promoter-enhancer loop anchoring activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64806", "l": "CoA + H(+) + S-(2-acetamidoethyl)-L-cysteine => acetyl-CoA + S-(2-aminoethyl)-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120295", "l": "histone serotonyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5669250", "l": "PAK1 phosphorylates FLNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.81", "l": "\"Flavone 7-O-beta-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55300", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445079", "l": "Phosphorylation of L1 by ERK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902485", "l": "L-cysteine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50890", "l": "an N-acyl-sphingoid base + phosphate => an N-acylsphingoid base 1-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47631", "l": "glyoxylate + H2O + propanoyl-CoA <=> 3-methylmalate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029453", "l": "Phosphorylation of VAV (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22653", "l": "2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + H2O => 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646295", "l": "p14ARF mutant does not translocate to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514790", "l": "Elastin degradation by MMP14 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-435244", "l": "PECAM1 is phosphorylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50061", "l": "ATP + glycochenodeoxycholate(in) + H2O => ADP + glycochenodeoxycholate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0009008", "l": "DNA-methyltransferase activity"}, {"i": "REACT:R-HSA-5227490", "l": "NoRC:HDAC:DNMT methylates cytosine of the rRNA genes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34688", "l": "AH2 + N-acyl-15-methylhexadecasphinganine + O2 => A + 2 H2O + N-acyl-15-methylhexadecasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45486", "l": "acetaldehyde + CO2 => H(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54567", "l": "5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O <=> a 5'-phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17603", "l": "ADP + D-ribulose 5-phosphate + H(+) => ATP + D-ribulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41065", "l": "2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46715", "l": "pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043719", "l": "2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322431", "l": "XIAP binds TLE (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103090", "l": "methylthiohexylmalate dehydrogenase activity"}, {"i": "MetaCyc:RXNQT-4174"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15461", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52751", "l": "alpha-isomaltosyl-(1->3)-isomaltose + H2O <=> 2 isomaltose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46207", "l": "androst-5-en-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> androst-5-en-3beta,7alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9679028", "l": "JAK3 binds JAK3 inhibitors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730840", "l": "Activation of RAC1 by VAV (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.119", "l": "\"Glucose 1-dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042961", "l": "ATPase-coupled antimonite transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684108", "l": "BRCA1 binds phosphorylated RBBP8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.1", "l": "\"Non-specific serine/threonine protein kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64817", "l": "5-aminolevulinate(in) => 5-aminolevulinate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12912", "l": "2 [Fe(II)cytochrome] + 2 H(+) + nitrate <=> 2 [Fe(III)cytochrome] + H2O + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36423", "l": "2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29190", "l": "succinate + ubiquinone-8 <=> fumarate + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0010209", "l": "vacuolar sorting signal binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19031", "l": "2 CO2 + 2 NH4(+) => 3 H(+) + H2O + urea-1-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183051", "l": "CBL ubiquitinates Sprouty (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9611839", "l": "β3-agonists bind ADRB3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43986", "l": "(2E,6E)-omega-hydroxy-farnesol + H2O + NADP(+) => (2E,6E)-farnesol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.138"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49376", "l": "12-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 12,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "57.776573636475689", "identifiers": [{"i": "GO:0016773", "l": "phosphotransferase activity, alcohol group as acceptor"}, {"i": "REACT:R-HSA-2161193", "l": "abacavir + AMP => abacavir monophosphate + adenosine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937807", "l": "SRC phosphorylates RUNX3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38217", "l": "6-phospho-D-glucono-1,5-lactone + H(+) + NADH => D-glucose 6-phosphate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49839", "l": "(5E)-tetradecenoyl-CoA + (R)-carnitine <=> (5E)-tetradecenoyl-(R)-carnitine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9705738", "l": "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210944", "l": "Endocytosis of cya:lef:(pagA(197-794):ANTXR1 oligomer) (plasma membrane to endosome membrane) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39082", "l": "(3S)-hydroxydodecanedioyl-CoA + NAD(+) <=> 3-oxododecanedioyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56381", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 chloride + 2 FADH2 + 2 O2 => (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 FAD + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5632649", "l": "Hh-Npp binds GAS1 and PTCH (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31575", "l": "8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H(+)"}, {"i": "EC:3.6.1.55", "l": "\"8-oxo-dGTP diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683656", "l": "mRNA4 is translated to protein E (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043423", "l": "3-phosphoinositide-dependent protein kinase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24179", "l": "[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645126", "l": "Activators bind STAT5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61901", "l": "AH2 + betaenone C => A + betaenone B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76466", "l": "CYP4A11 12-hydroxylates DDCX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57177", "l": "L-arginyl-[protein] + methylglyoxal => N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75862", "l": "Fall Back to Closed Pre-initiation Complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68826", "l": "Free CDT1 associates with CDC6:ORC:origin complexes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55738", "l": "[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP => alpha-D-galacturonosyl-[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n) + UDP-beta-L-rhamnose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59615", "l": "beta-alanyl-L-ornithine + H2O <=> beta-alanine + L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694563", "l": "ABHD10 hydrolyses MPAG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371435", "l": "Constitutive phosphorylation by GSK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54089", "l": "3,4-dihydroxyphenylacetate + H(+) + NADH + O2 => 2,4,5-trihydroxyphenylacetate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62186", "l": "diphosphate + labd-13(16),14-diene-9-ol => peregrinol diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12867", "l": "1-methyladenine + D-ribose => 1-methyladenosine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11343", "l": "5-guanidino-2-oxopentanoate + H(+) <=> 4-guanidinobutanal + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004362", "l": "glutathione-disulfide reductase (NADPH) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56364", "l": "13-dihydrocarminomycin + H(+) + NADPH + O2 = carminomycin + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507873", "l": "Aquaporins passively transport urea out of cells (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37898", "l": "H2O + protodioscin <=> 26-deglucoprotodioscin + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700131", "l": "ALK mutants bind type I TKIs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22741", "l": "ATP + D-hexose => ADP + D-hexose 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166792", "l": "Conversion of C2 into C2a and C2b (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36675", "l": "octacosanoyl-CoA + sphinganine = CoA + H(+) + N-(octacosanoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.43"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443831", "l": "14-3-3-zeta binds Raf1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21359", "l": "L-arabinitol + NAD(+) <=> H(+) + L-ribulose + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5627775", "l": "Autophosphorylation of PAK1,2,3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48672", "l": "20-oxo-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662473", "l": "KGPDC decarboxylates 3-dehydro-L-gulonate to L-xylulose (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75850", "l": "Addition of the third nucleotide on the nascent transcript (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "68.460472936803939", "identifiers": [{"i": "GO:0001653", "l": "peptide receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-452122", "l": "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111966", "l": "GRK2 binds CALM1:4Ca2+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53574", "l": "20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805943", "l": "S100A1 binds TLR4:LY96 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44991", "l": "(R)-carnitine + 2-methylpropanoyl-CoA <=> CoA + O-isobutanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21217", "l": "ATP + D-ribose 5-phosphate => ADP + alpha-D-ribose 1,5-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9641111", "l": "Parkin transfers Ub to misfolded proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26522", "l": "(2S,3S)-2-methylcitrate = 2-methyl-trans-aconitate + H2O"}, {"i": "EC:4.2.1.117", "l": "\"2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27514", "l": "H2O + sphinganine 1-phosphate = phosphate + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570493", "l": "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61513", "l": "malvidin + UDP-alpha-D-glucose => malvidin 3-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10435", "l": "2-(acetamidomethylene)succinate + H(+) + 2 H2O <=> acetate + CO2 + NH4(+) + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20109", "l": "alpha-D-ribose 1,5-bisphosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + ADP"}, {"i": "EC:2.7.4.23", "l": "\"Ribose 1,5-bisphosphate phosphokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110213", "l": "NTHL1 glycosylase mediated recognition and binding of formamidopyrimidine (FapyA) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804379", "l": "PRMT5 binds TTC5 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38562", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + tetracosanoate <=> (R)-2-hydroxytetracosanoate + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30679", "l": "D-cellobiose + H2O = 2 beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66316", "l": "an inositol phosphomannosyl-alpha-1->6-inositol-1-phospho-N-acyl-4R-hydroxysphinganine + H2O = alpha-D-mannosyl-di-(inositol-1-phosphate) + an N-acyl-(4R)-4-hydroxysphinganine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52657", "l": "a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+) => a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-202111", "l": "AKT1 phosphorylates eNOS (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798743", "l": "Exocytosis of secretory granule membrane proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60564", "l": "2-deoxy-D-glucose + ATP = 2-deoxy-D-glucose 6-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51645", "l": "cholesterol + H(+) + NADH + O2 => cholesta-5,7-dien-3beta-ol + 2 H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803890", "l": "SFN dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.16"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624948", "l": "KIF17 enters the cilium (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002059", "l": "thymine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51576", "l": "phloretin + UDP-alpha-D-glucose = H(+) + phlorizin + UDP"}, {"i": "EC:2.4.1.357", "l": "\"Phlorizin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67126", "l": "an alcohol + S-hydroxy-L-cysteinyl-[protein] => a hydroperoxide + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63718", "l": "losartan-1-N-beta-D-glucuronide + UDP => losartan + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12640", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose <=> (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070448", "l": "laricitrin 5'-O-methyltransferase activity"}, {"i": "RHEA:25633", "l": "laricitrin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + syringetin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11798", "l": "3-dehydroecdysone + H2O2 => ecdysone + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20149", "l": "O2 + quinine + reduced [NADPH--hemoprotein reductase] = 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.55", "l": "\"Quinine 3-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48851", "l": "(9Z,12Z)-octadecadienoate + O2 <=> 13-hydroperoxy-(9Z,11E)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295632", "l": "PPA2A dephosphorylates SPRY2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57087", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O <=> a fatty acid + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62081", "l": "D-glucose 6-sulfate + NADP(+) => 6-sulfo-D-glucono-1,5-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189062", "l": "lactose + H2O => D-glucose + D-galactose (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379387", "l": "COMT transfers Met to DA to form 3MT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382057", "l": "Release of novel PDGFs as latent factors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22113", "l": "isoxazolin-5-one + O-acetyl-L-serine => 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009910", "l": "IL37(?-218) binds p-S423,S425-SMAD3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12252", "l": "4-O-(beta-D-glucosyl)-trans-coniferol + H2O = (E)-coniferol + D-glucose"}, {"i": "EC:3.2.1.126", "l": "\"Coniferin beta-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.64", "l": "\"Testosterone 17-beta-dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52721", "l": "5-methyluridine(54) in tRNA + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + ATP + H2O => 5-methyl-2-thiouridine(54) in tRNA + [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + AMP + diphosphate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983700", "l": "SYK binds the activated BCR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912394", "l": "NICD1 in complex with RBPJ (CSL) recruits MAML (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853745", "l": "RET binds GFRA1,GFRA3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008913", "l": "lauroyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12200", "l": "2'-deoxymugineate + 2-oxoglutarate + O2 = CO2 + mugineate + succinate"}, {"i": "EC:1.14.11.24", "l": "\"2'-deoxymugineic-acid 2'-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27632", "l": "glycolaldehyde + H(+) + NADH => ethylene glycol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10924", "l": "cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide = trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide"}, {"i": "EC:5.2.1.10", "l": "\"2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.301", "l": "\"2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044548", "l": "S100 protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53336", "l": "5,6-dihydrouridine(20) in tRNA + NADP(+) = H(+) + NADPH + uridine(20) in tRNA"}, {"i": "RHEA:53340", "l": "5,6-dihydrouridine(20) in tRNA + NAD(+) = H(+) + NADH + uridine(20) in tRNA"}, {"i": "EC:1.3.1.91", "l": "\"tRNA-dihydrouridine(20) synthase (NAD(P)(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65638", "l": "CoA + H(+) + N-tetracosanoylsphinga-(4E,8E)-dienine => sphinga-(4E,8E)-dienine + tetracosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029471", "l": "Hydrolysis of PC to PA by PLD (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49332", "l": "2-hydroxyspheroidene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2,2-dihydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30928", "l": "2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnose + H2O => 5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36298", "l": "alpha-maltose 6'-phosphate + H2O <=> D-maltose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865182", "l": "OTUD7A hydrolyses K11diUb (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876484", "l": "NPC2 transfers CHOL to NPC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19879", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32353", "l": "3',4',5'-O-trimethyltricetin + 3 H(+) + 3 S-adenosyl-L-homocysteine => 3 S-adenosyl-L-methionine + tricetin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050175", "l": "phenylalanine dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37859", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA = 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1474266", "l": "Formation of collagen fibrils (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27557", "l": "all-trans-hexaprenyl diphosphate + 2 diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + 2 isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375135", "l": "Basigin binds Matrix metalloproteinase-1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31133", "l": "(6S)-5,6,7,8-tetrahydrofolate + 2 H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide => 5,10-methenyltetrahydrofolate + H2O + N(1)-(5-phospho-beta-D-ribosyl)glycinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675198", "l": "Activated MAPKs phosphorylate BRAF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65301", "l": "2-oxoglutarate + chrodrimanin C + O2 => CO2 + H2O + succinate + verruculide A"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080041", "l": "ADP-ribose pyrophosphohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29204", "l": "dimethyl sulfoxide + menaquinol-8 => dimethyl sulfide + H2O + menaquinone-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46665", "l": "corticosterone + H(+) + NADPH => 5beta-dihydrocorticosterone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46629", "l": "3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH => androst-5-en-3beta,17beta-diol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004122", "l": "cystathionine beta-synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3095889", "l": "MMACHC reduces Cbl (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807872", "l": "Active ARF recruits coatomer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60724", "l": "dodecanal + H2O + NADP(+) = dodecanoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944227", "l": "Association of procollagen type XXII (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51702", "l": "4'-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + xanthogalenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32484", "l": "H(+) + H2O + pheophorbide a => CO2 + methanol + pyropheophorbide a"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112435", "l": "Formation of Elongin BC complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56526", "l": "AH2 + heme d1 => A + dihydro-heme d1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10583", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + ATP + L-glutamate <=> (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n+1 + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47390", "l": "an aliphatic alcohol + H(+) + tetradecanoate => a tetradecanoate ester + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111970", "l": "PKC phosphorylates GRK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41227", "l": "(S)-4-hydroxymandelate + O2 = 4-hydroxyphenylglyoxylate + H2O2"}, {"i": "EC:1.1.3.46", "l": "\"4-hydroxymandelate oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15174", "l": "H(+) + H2O2 + NADPH => 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29166", "l": "2 H(+)(out) + 3 menaquinol-8(in) + nitrite(out) <=> 2 H2O(out) + 3 menaquinone-8(in) + NH4(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48881", "l": "a quinone + CO + H2O => a quinol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035276", "l": "ethanol binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031489", "l": "myosin V binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017120", "l": "IK1 binds the PTCRA gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139899", "l": "Sequestration of BAD protein by 14-3-3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141409", "l": "Mad1 binds kinetochore (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174786", "l": "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159194", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602484", "l": "Activation of proMMP11 by FURIN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61211", "l": "8-nitro-cGMP + L-cysteinyl-[protein] <=> H(+) + nitrite + S-(guanosine 3',5'-cyclic phosphate)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428231", "l": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2129357", "l": "Fibrillin C-terminal processing (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60862", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28874", "l": "D-fructuronate(in) + H(+)(in) <=> D-fructuronate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53535", "l": "(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate <=> (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49549", "l": "H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] => H(+) + L-arginyl-[protein] + lactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5368586", "l": "DKK promotes clathrin-dependent internalization of LRP6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102209", "l": "trans-permethrin hydrolase activity"}, {"i": "RHEA:30283", "l": "(-)-trans-permethrin + H2O = (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+)"}, {"i": "EC:3.1.1.88", "l": "\"Pyrethroid hydrolase\""}]}
{"type": "biolink:MolecularActivity", "ic": "80.155824608458104", "identifiers": [{"i": "GO:0045182", "l": "translation regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21160", "l": "acetyl-CoA + ADP + oxaloacetate + phosphate = ATP + citrate + CoA"}, {"i": "EC:2.3.3.8", "l": "\"ATP citrate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44007", "l": "3-methyl fatty acid + ATP + CoA <=> a 3-methyl fatty acyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66589", "l": "a cytidine in 26S rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in 26S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189439", "l": "ALAD condenses 2 dALAs to form PBG (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18691", "l": "a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64321", "l": "(9Z)-hexadecenoyl-CoA + cholesterol => cholesteryl (9Z)-hexadecenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31707", "l": "2 H(+) + O2 + pentalen-13-ol + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9734687", "l": "ORC6 is phosphorylated on T195 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39532", "l": "3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17759", "l": "3-(methylsulfanyl)propanamine + CO2 => H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66179", "l": "ATP + H2O + taurochenodeoxycholate 3-sulfate(in) <=> ADP + H(+) + phosphate + taurochenodeoxycholate 3-sulfate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983158", "l": "Trimming of peptides in ER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32375", "l": "limonene-1,2-diol + NAD(+) = 1-hydroxylimonen-2-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16907", "l": "a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052728", "l": "capsorubin synthase activity"}, {"i": "RHEA:21752", "l": "all-trans-violaxanthin = all-trans-capsorubin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20456", "l": "scopoletin + UDP-alpha-D-glucose <=> H(+) + scopolin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1299297", "l": "Activation of THIK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32880", "l": "(1R,4R,5R)-5-hydroxycamphor + NAD(+) => (1R,4R)-bornane-2,5-dione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389381", "l": "Gads binds CD28 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236947", "l": "Egress of internalized antigen to the cytosol via sec61 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37320", "l": "ATP + glycyl-L-methionine(out) + H2O => ADP + glycyl-L-methionine(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36442", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32896", "l": "1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] => 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627072", "l": "RHOQ binds GOPC:CFTR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42441", "l": "L-aspartate + NAD(+) => H(+) + iminosuccinate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0140658", "l": "ATP-dependent chromatin remodeler activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62492", "l": "ATP + holo-[peptidyl-carrier protein] + L-arginine = AMP + diphosphate + L-arginyl-[peptidyl-carrier protein]"}, {"i": "EC:6.2.1.63", "l": "\"L-arginine--[L-arginyl-carrier protein] ligase\""}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0045543", "l": "gibberellin 2-beta-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33355", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322431", "l": "XIAP binds TLE (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33242", "l": "L-threonine + NAD(+) <=> aminoacetone + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11738", "l": "6-oxocineole + H(+) + NADH => 2-exo-hydroxy-1,8-cineole + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177922", "l": "EGFR dimerization (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682010", "l": "ATG10:ATG12 binds ATG5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975873", "l": "IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015127", "l": "bilirubin transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047215", "l": "indole-3-acetate beta-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57007", "l": "acetyl-CoA + streptothricin D <=> CoA + H(+) + N(beta)-acetylstreptothricin D"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013145", "l": "RAC1 binds effectors at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30077", "l": "cytosine + D-ribose 5-phosphate => CMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40596", "l": "dodecanedioyl-CoA + H2O => CoA + dodecanedioate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917839", "l": "apo-Transferrin dissociates from the receptor complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847544", "l": "The COG complex and CUX1 and GOLGA5 dimers contribute to intra-Golgi vesicle tethering (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5672011", "l": "p-AMPK:AMP binds the ULK complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34477", "l": "15-cis-phytoene + 2 diphosphate => 2 (2E,6E,10E)-geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.61", "l": "\"Mycodextranase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052773", "l": "diacetylchitobiose deacetylase activity"}, {"i": "MetaCyc:RXN-12543"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8853496", "l": "SCF:FBXL7 binds AURKA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63785", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939833", "l": "RUNX2:CBFB binds the ITGBL1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017084", "l": "delta1-pyrroline-5-carboxylate synthetase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65972", "l": "a peptide antigen(in) + ATP + H2O = a peptide antigen(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19042", "l": "(25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase] => (25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193641", "l": "IKK-beta is recruited (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634228", "l": "TRAF1 is cleaved by caspases (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45655", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10343", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-vetispiradiene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4331324", "l": "E2F1 binds BBC3 (PUMA) promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636240", "l": "PPE2 binds NOS2 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44968", "l": "(2E)-tetradecenoyl-CoA + H(+) + NADPH = NADP(+) + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38114", "l": "glycerol + NADP(+) <=> H(+) + L-glyceraldehyde + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018699", "l": "1,1,1-trichloroethane reductive dehalogenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050131", "l": "N-methyl-L-amino-acid oxidase activity"}, {"i": "MetaCyc:N-METHYL-L-AMINO-ACID-OXIDASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13730", "l": "FAD => AMP + H(+) + riboflavin cyclic-4',5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57543", "l": "5'-NTP-ribonucleotide-RNA + H2O <=> 5'-phospho-ribonucleosidyl-ribonucleotide-RNA + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54051", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> 4-epi-cubebol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442715", "l": "Calmodulin-activated adenylate cyclases ADCY1 and ADCY8 generate cAMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45795", "l": "2-oxoglutarate + [ribosomal protein S23]-L-proline + O2 <=> [ribosomal protein S23]-trans-3-hydroxy-L-proline + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66986", "l": "CoA + H(+) + isovalerate => 3-methylbutanoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198669", "l": "p38MAPK phosphorylates MSK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111956", "l": "Calmodulin activates Cam-PDE 1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690152", "l": "USP5 cleaves polyubiquitin (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47738", "l": "5-methylcytidine(1404) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1404) in 16S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696271", "l": "RND1 binds effectors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40400", "l": "1,2-dihydro-beta-NADP + H(+) + O2 => H2O2 + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194678", "l": "CYP51A1 demethylates LNSOL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31990", "l": "(S)-2,3-epoxysqualene <=> baruol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28084", "l": "(2E)-butenoyl-CoA + CO2 + NADPH => (2S)-ethylmalonyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13815", "l": "cis-1,2-dihydrobenzene-1,2-diol + NAD(+) => benzene + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867041", "l": "EGFR phosphorylates EPS15 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22102", "l": "3,5-dibromo-4-hydroxybenzoate + NH4(+) => 3,5-dibromo-4-hydroxybenzonitrile + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202233", "l": "Inactivation of Lck by Csk (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419003", "l": "Interaction of Nectins with Afadin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12463", "l": "(S)-malate <=> fumarate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37528", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682012", "l": "ATG5:ATG12 binds ATG16L1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080124", "l": "pheophytinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6803890", "l": "SFN dimerizes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22335", "l": "(3R)-citramalate <=> 2-methylmaleate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350651", "l": "Caspase-mediated cleavage of MASK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58479", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine <=> a 1-acyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67157", "l": "1-O-(1Z-hexadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41722", "l": "(9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphocholine + H(+) => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682010", "l": "ATG10:ATG12 binds ATG5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374896", "l": "Uptake of Noradrenaline (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56902", "l": "globoside GlcNAc-(beta1->6)-GalGb4Cer + H(+) + UDP => globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938314", "l": "ENPPs hydrolyse CoA-SH to PPANT, PAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400023", "l": "Gq alpha activates Phospholipase C beta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015136", "l": "sialic acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.8"}]}
{"type": "biolink:MolecularActivity", "ic": "68.3621111081913", "identifiers": [{"i": "GO:0015081", "l": "sodium ion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23804", "l": "N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate"}, {"i": "EC:5.4.2.3", "l": "\"Phosphoacetylglucosamine mutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210881", "l": "Dimerization of Tie2/Ang1 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016719", "l": "carotene 7,8-desaturase activity"}, {"i": "RHEA:15701", "l": "AH2 + all-trans-neurosporene + O2 = A + all-trans-lycopene + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605736", "l": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664306", "l": "LTC4 binds CyslTR1,2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59261", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) + H2O => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37940", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63844", "l": "[thioredoxin]-dithiol + cumene hydroperoxide = 2-phenylpropan-2-ol + [thioredoxin]-disulfide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39111", "l": "4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NADP(+) = 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20843", "l": "H(+) + L-histidine <=> CO2 + histamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27783", "l": "4-hydroxybenzoate + all-trans-octaprenyl diphosphate => 4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50615", "l": "decanal + NADP(+) <=> (2E)-decenal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12842", "l": "pyridoxamine + pyruvate => L-alanine + pyridoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70494", "l": "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685318", "l": "BCDX2 complex formation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40003", "l": "ent-copalyl diphosphate = (Z)-biformene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674140", "l": "PAQR3 binds inactive RAFs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4568740", "l": "AP-1 stimulates IL1A transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015446", "l": "ATPase-coupled arsenite transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10711", "l": "alpha-D-glucose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39612", "l": "3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-114284", "l": "Release of Cytochrome c from mitochondria (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250488", "l": "GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19524", "l": "acetyl-CoA + phosphate <=> acetyl phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140339", "l": "phosphatidylglycerol transfer activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66365", "l": "(3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H2O => 6-methyl-3,7-dioxodecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45146", "l": "acetaldehyde + CO2 + CoA + methanethiol => 3-(methylsulfanyl)acryloyl-CoA + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66085", "l": "L-kynurenine + oxaloacetate => H2O + kynurenate + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48555", "l": "1-(9S,13S-12-oxo-10,15Z-phytodienoyl)-2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O <=> (10Z,15Z)-12-oxophytodienoate + 2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15854", "l": "17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(+) => 17alpha-hydroxyprogesterone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63011", "l": "(6Z)-octadecenamide + H2O <=> (6Z)-octadecenoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004917", "l": "interleukin-7 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53536", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O = (13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047730", "l": "carnosine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20331", "l": "ADP + H(+) + O-phospho-L-seryl-[low-density-lipoprotein receptor] => ATP + L-seryl-[low-density-lipoprotein receptor]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61572", "l": "(11Z,14Z)-eicosadienoate + O2 = (15S)-hydroperoxy-(11Z,13E)-eicosadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60822", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide => H2O + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55824", "l": "a 7(1),7(1)-dihydroxybacteriochlorophyllide d = a bacteriochlorophyllide f + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65224", "l": "(1R,2R)-1,2-dihydronaphthalene-1,2-diol + NADP(+) = H(+) + NADPH + naphthalene-1,2-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34964", "l": "Na(+)(in) => Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44411", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O <=> a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58601", "l": "2 L-ascorbate + N-(9Z-octadecenoyl)glycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-(9Z-octadecenoyl)-(2S)-hydroxyglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58520", "l": "(19S)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] = akuammicine + formate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200143", "l": "AKT phosphorylates AKT1S1 (PRAS40) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33400", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate(out) => L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25812", "l": "H2O + N(1)-acetylspermidine + O2 = 3-acetamidopropanal + H2O2 + putrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30848", "l": "FAD + glutaryl-CoA + 2 H(+) => (2E)-butenoyl-CoA + CO2 + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30426", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-delta-selinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40045", "l": "ADP + beta-citrylglutamate + H(+) + phosphate => ATP + citrate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36992", "l": "phosphate + UMP => alpha-D-ribose 1,5-bisphosphate + uracil"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70613", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482629", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033777", "l": "lithocholate 6beta-hydroxylase activity"}, {"i": "KEGG.REACTION:R07203"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672961", "l": "PP2A dephosphorylates inactive RAFs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50738", "l": "a quinol + thiosulfate => a quinone + 2 H(+) + hydrogen sulfide + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36669", "l": "CoA + H(+) + N-(15Z-tetracosenoyl)-sphinganine => (15Z)-tetracosenoyl-CoA + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15209", "l": "(2R,3R)-tartrate + NAD(+) = 2-hydroxy-3-oxosuccinate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534388", "l": "Progesterone Activation Of CatSper (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429955", "l": "CCR4-NOT complex deadenylates mRNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173705", "l": "C5b binds C6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453200", "l": "SYK autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25353", "l": "H(+) + L-cysteine + tRNA(Pro) => H2O + L-cysteinyl-tRNA(Pro)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647978", "l": "pro-RAS proteins are farnesylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420975", "l": "Ca impermeable AMPA receptor ligand binding (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20833", "l": "ATP + guanine(out) + H2O => ADP + guanine(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987039", "l": "JAK1 binds IL20RA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37253", "l": "cysteamine + phosphate => cysteamine S-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23294", "l": "ADP + H(+) + N-phospho-L-lombricine => ATP + L-lombricine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102635", "l": "11-deoxycorticosterone reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29485", "l": "(+)-beta-selinene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28520", "l": "D-glycero-beta-D-manno-heptose 1-phosphate + phosphate => D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56197", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-alpha-D-galactose => H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57788", "l": "1,3-dinitrobenzene + NADH + O2 = 4-nitrocatechol + H(+) + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034524", "l": "2-hydroxyisophthalate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043829", "l": "tRNA-specific adenosine-37 deaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26040", "l": "beta-D-fructose 6-phosphate + GDP-alpha-D-mannose => beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44440", "l": "a 1,3-diacylglycerol + a 1-acylglycerol = a triacylglycerol + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52644", "l": "D-xylono-1,4-lactone 5-phosphate + H2O = 5-phospho-D-xylonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49508", "l": "phosphinomethylmalate = 2-(phosphinatomethylidene)butanedioate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868118", "l": "MAPK12 phosphorylates PTPN3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607043", "l": "factor VIIIa associates with cell membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50747", "l": "2 glyphosate + O2 <=> 2 aminomethylphosphonate + 2 glyoxylate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58429", "l": "(E,E)-2,4-hexadien-1-ol + NADP(+) => (E,E)-2,4-hexadienal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20992", "l": "16-hydroxytabersonine + S-adenosyl-L-methionine = 16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.94", "l": "\"Tabersonine 16-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54801", "l": "[nsP1 protein]-N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidine + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) => [nsP1 protein]-L-histidine + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12450", "l": "(R)-pantoate + beta-alanine => (R)-pantothenate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192832", "l": "Initiation of cRNA Synthesis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3781941", "l": "WNTs are secreted in exosomes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19072", "l": "(R)-S-lactoylglutathione <=> glutathione + methylglyoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23774", "l": "2,3-dihydroxy-p-cumate + H(+) + NADH => (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66747", "l": "ATP + H2O + N-acetyl-L-aspartate(in) <=> ADP + H(+) + N-acetyl-L-aspartate(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163090", "l": "Elongation Of The Telomeric Chromosome End (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58191", "l": "all-trans-lycopene + dimethylallyl diphosphate + H2O <=> dihydroisopentenyldehydrorhodopin + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850818", "l": "SPINK9 binds KLK5 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30029", "l": "glycerol + NAD(+) => D-glyceraldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34146", "l": "cannabinerolate + O2 <=> Delta(9)-tetrahydrocannabinolate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36343", "l": "2-methylsulfanyl-N(6)-(Delta(2)-isopentenyl)adenosine in tRNA + H(+) + NADPH + O2 = 2-methylsulfanyl-N(6)-(cis-4-hydroxy-Delta(2)-isopentenyl)adenosine in tRNA + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811472", "l": "IER3 recruits MAPKs to PP2A-B56-beta,gamma (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559464", "l": "TLR6/2 ligand associates with CD14 and CD36 within lipid rafts (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14242", "l": "3-amino-4-hydroxybenzaldehyde + acetyl-CoA => 3-acetylamino-4-hydroxybenzaldehyde + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196753", "l": "2xPPCS ligates PPanK with Cys (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22566", "l": "a (2E)-enoyl-[ACP] + H(+) + NADPH => a 2,3-saturated acyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013023", "l": "RHOB GEFs activate RHOB (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-378975", "l": "Follitropin is a heterodimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15032", "l": "D-mannitol + NAD(+) <=> D-mannose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433451", "l": "JAK2 binds to p-KIT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013023", "l": "RHOB GEFs activate RHOB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372422", "l": "oxaloacetate + NADH + H+ <=> malate + NAD+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937177", "l": "AHR:TCDD binds ARNT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508451", "l": "PTK2B is phosphorylated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22927", "l": "dCMP + H(+) + H2O <=> dUMP + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5681980", "l": "ATG12 binds ATG7 dimer (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24220", "l": "beta-myrcene + O2 + reduced [NADPH--hemoprotein reductase] = (4R)-ipsdienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.31", "l": "\"Ipsdienol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22537", "l": "(S)-tetrahydrocolumbamine + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + tetrahydropalmatine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975115", "l": "IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.30"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46716", "l": "pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015048", "l": "phthalate dioxygenase reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168459", "l": "Lyn activates ERK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676593", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050620", "l": "phycocyanobilin:ferredoxin oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388855", "l": "Prolactin-releasing hormone receptor binds PRH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42025", "l": "3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) => 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54146", "l": "5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 CO2 + H2O + 2 succinate => 2 2-oxoglutarate + 5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848077", "l": "PTK6 phosphorylates STAP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391936", "l": "EP1 receptor can bind PGE2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684275", "l": "IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12663", "l": "CoA + O-hexadecanoyl-(R)-carnitine => (R)-carnitine + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047163", "l": "3,4-dichloroaniline N-malonyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052599", "l": "methylputrescine oxidase activity"}, {"i": "MetaCyc:RXN-8244"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021596", "l": "Membrane estrogen receptors bind SRC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14344", "l": "2-oxoglutarate + glyoxylate + H(+) <=> 2-hydroxy-3-oxoadipate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110244", "l": "Excision of FapyG by OGG1 glycosylase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31580", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate => (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15844", "l": "D-glucose 6-phosphate + NADP(+) <=> 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508513", "l": "PTK2B binds JAK3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205205", "l": "Interaction of Src family kinases with p-KIT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042880", "l": "D-glucuronate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.1", "l": "\"Alpha-amylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45864", "l": "16-hydroxyhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2173781", "l": "MARCO (SCARA2) binds ligands (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.55"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199169", "l": "MHC Class I interacts with CD160 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749197", "l": "ORC1 binds to H4K20me2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37779", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38952", "l": "ATP + H2O + sphing-4-enine 1-phosphate(in) => ADP + H(+) + phosphate + sphing-4-enine 1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202291", "l": "Activation of Lck (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110311", "l": "POLZ extends translesion synthesis (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66460", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O = 14betaH-scalarane-17alpha-19-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28873", "l": "D-fructuronate(out) + H(+)(out) => D-fructuronate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27317", "l": "dichlorochromopyrrolate + 6 H(+) + 4 NADH + 4 O2 <=> 2 CO2 + dichloroarcyriaflavin A + 6 H2O + 4 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102442", "l": "syringetin 3-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-13920"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989777", "l": "Expression of RGL1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-354173", "l": "Activation of Rap1 by cytosolic GEFs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67158", "l": "(9Z)-octadecenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+) => 1-O-(1Z-hexadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50256", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13350", "l": "jasmonate + S-adenosyl-L-methionine => methyl (-)-jasmonate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944214", "l": "Association of procollagen type I (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.6.2.1", "l": "\"P-type phospholipid transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218814", "l": "PAK2 autophorylates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55402", "l": "archaeosine(15) in tRNA => 7-cyano-7-carbaguanosine(15) in tRNA + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54419", "l": "5alpha-campestan-3-one + NADP(+) <=> campest-4-en-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54124", "l": "coelenterazine h dioxetanone = CO2 + excited coelenteramide h monoanion + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029680", "l": "Caspase-7 translocates to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674018", "l": "BRAP binds RAS:GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40345", "l": "acetyl-CoA + tetradecanedioyl-CoA => 3-oxohexadecanedioyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635859", "l": "GLI:SUFU dissociates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66745", "l": "ATP + H2O + N-acetyl-L-aspartate(in) => ADP + H(+) + N-acetyl-L-aspartate(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56685", "l": "dihydrorhizobitoxine + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + rhizobitoxine"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0000146", "l": "microfilament motor activity"}, {"i": "EC:5.6.1.8", "l": "\"Myosin ATPase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45777", "l": "(indol-3-yl)acetonitrile + 2 H2O => (indol-3-yl)acetate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38565", "l": "1-O-hexadecyl-sn-glycerol + acetate + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61782", "l": "keto-L-sorbose => keto-L-tagatose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874979", "l": "ACBD3 binds GOLGB1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55553", "l": "N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449811", "l": "IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28317", "l": "baicalein + UDP-alpha-D-glucuronate <=> baicalin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189488", "l": "UROS transforms HMB to URO3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32300", "l": "2 (2E,6E)-farnesyl diphosphate + H(+) + NADH => 2 diphosphate + NAD(+) + squalene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57793", "l": "3,4-dinitrotoluene + NADH + O2 => 4-methyl-6-nitrocatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12926", "l": "D-erythrose 4-phosphate + L-lysyl-[protein] => H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58760", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165129", "l": "GDP is exchanged for GTP on DRheb (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14183", "l": "(3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008478", "l": "pyridoxal kinase activity"}, {"i": "MetaCyc:PYRIDOXKIN-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23798", "l": "acetate + H(+) + norajmaline => 17-O-acetylnorajmaline + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72621", "l": "Ribosomal scanning  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032093", "l": "SAM domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56704", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 = 3-[(E)-2-isocyanovinyl]indole + 2 CO2 + H2O + succinate"}, {"i": "EC:1.14.20.12", "l": "\"3-((E)-2-isocyanoethenyl)-1H-indole synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0051920", "l": "peroxiredoxin activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014296", "l": "RAC2 GEFs activate RAC2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373707", "l": "Netrin-1 induced DCC clustering (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22358", "l": "CO2 + phosphate + phosphoenolpyruvate => diphosphate + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4720432", "l": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047380", "l": "ADP-dependent medium-chain-acyl-CoA hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39676", "l": "(9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44413", "l": "3-demethylubiquinol-10 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.38", "l": "\"Gametolysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41206", "l": "1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28779", "l": "4-hydroxy-L-threonine = glycine + glycolaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024785", "l": "RvD1-6 translocate from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625841", "l": "Defective SLC24A1 does not exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199579", "l": "KIR2DL4 interacting with HLA-G (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181156", "l": "Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851908", "l": "Activated MET binds GAB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59020", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = (9Z,12Z)-octadecadienoate + di-(9Z,12Z)-octadecadienoylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865275", "l": "PDGF-BB clevage by Furin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085347", "l": "PIAS1 SUMOylates SAFB with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61065", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-glucosamine => beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024967", "l": "BDNF-bound NTRK2 dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51346", "l": "8,9-epoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O => (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004843", "l": "thiol-dependent deubiquitinase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5333051", "l": "RPA1 binds HSF1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004533", "l": "exoribonuclease H activity"}, {"i": "MetaCyc:3.1.13.2-RXN"}, {"i": "EC:3.1.13.2", "l": "\"Exoribonuclease H\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693198", "l": "RHOD binds effectors at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16082", "l": "(2R)-S-methyl-3-phospho-1-thioglycerate + H2O => (2R)-S-methyl-1-thioglycerate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54705", "l": "N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25562", "l": "9beta-pimara-7,15-diene + diphosphate => 9alpha-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34314", "l": "4-nitrocatechol + NADH + O2 <=> 2-hydroxy-1,4-benzoquinone + H2O + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371422", "l": "ATP hydrolysis by HSP70 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30020", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP + H(+) + lipid A-core"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788628", "l": "p-Y-STATs dissociate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53750", "l": "a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34000", "l": "5alpha-cholesta-8,24-dien-3beta-ol => 5alpha-cholesta-7,24-dien-3beta-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29310", "l": "FMNH2 + methanesulfonate + O2 <=> FMN + formaldehyde + 2 H(+) + H2O + sulfite"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018485", "l": "salicylaldehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627056", "l": "Procaspase 9 forms dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191636", "l": "Phosphorylation of Cx43 by c-src (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39027", "l": "a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP"}, {"i": "RHEA:39031", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP"}, {"i": "EC:2.4.1.315", "l": "\"Diglucosyl diacylglycerol synthase (1,6-linking)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42307", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37967", "l": "galactitol + NADP(+) = D-galactose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58865", "l": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 => 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34695", "l": "(2E,6E)-farnesyl diphosphate = Delta(6)-protoilludene + diphosphate"}, {"i": "EC:4.2.3.135", "l": "\"Delta(6)-protoilludene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57621", "l": "dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928646", "l": "EPHAs bind EFNAs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62496", "l": "ATP + H(+) + L-arginine = diphosphate + L-arginyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018112", "l": "proline racemase activity"}, {"i": "RHEA:10680", "l": "L-proline = D-proline"}, {"i": "EC:5.1.1.4", "l": "\"Proline racemase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204434", "l": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062082", "l": "HLA-E specific inhibitory MHC class Ib receptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036307", "l": "23S rRNA (adenine(2030)-N(6))-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54333", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173754", "l": "Properdin stabilizes C3b:Bb bound to cell surfaces (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17235", "l": "L-fuculose => L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451418", "l": "Pellino ubiquitinates IRAK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41607", "l": "1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2974731", "l": "Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2327733", "l": "FN1 binds Collagen types I-V, VII (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9619376", "l": "CAMK1 binds calmodulin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35095", "l": "choline = acetaldehyde + trimethylamine"}, {"i": "EC:4.3.99.4", "l": "\"Choline trimethylamine-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013108", "l": "GDIs block activation of RHOC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174757", "l": "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33422", "l": "[(1R)-2,2,3-trimethyl-2-oxocyclopent-3-en-1-yl]acetate + ATP + CoA <=> [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49991", "l": "acetone + H(+) + NADPH + O2 <=> H2O + methyl acetate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871193", "l": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202325", "l": "Recruitment of Gads to LAT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055043", "l": "5-oxovalerate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42044", "l": "GDP-beta-L-fucose + globoside GalGb4Cer (d18:1(4E)) = GDP + globoside Globo-H (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442749", "l": "CaMKK autophosphorylates in the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605717", "l": "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3828025", "l": "DCN (decorin) degradation by MMP14 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140347", "l": "N-retinylidene-phosphatidylethanolamine flippase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18758", "l": "2-oxoglutarate + 7-deoxycylindrospermopsin + O2 => CO2 + cylindrospermopsin + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53232", "l": "cholesta-5,24-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-25-epoxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21525", "l": "3-methyl-2-oxobutanoate + acetyl-CoA + H2O => (2S)-2-isopropylmalate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24702", "l": "NAD(+) + UDP-alpha-D-glucuronate = CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose"}, {"i": "EC:1.1.1.305", "l": "\"UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic acid decarboxylating)\""}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0055056", "l": "D-glucose transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62134", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + dTDP => a 2'-deoxyribonucleoside 5'-phosphate + dTTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20411", "l": "D-glucose + FMN => alpha-D-glucose 1-phosphate + riboflavin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389481", "l": "Orexin 1 receptor can bind orexin-A neuropeptide (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38054", "l": "2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA <=> 1-butyryl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34263", "l": "dimethylallyl diphosphate + fumigaclavine A = diphosphate + fumigaclavine C"}, {"i": "EC:2.5.1.100", "l": "\"Fumigaclavine A dimethylallyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45763", "l": "dTDP-beta-L-daunosamine + epsilon-rhodomycinone <=> dTDP + H(+) + rhodomycin D"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45235", "l": "a (2E,4Z)-dienoyl-CoA + H(+) + NADPH <=> a 4,5-saturated-(2E)-enoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50023", "l": "decanoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + decanoyl-4'-phosphopantetheine + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18244", "l": "D-lysine <=> (2R,5S)-2,5-diaminohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19063", "l": "H(+) + NADPH + nitrate => H2O + NADP(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "71.632434359930443", "identifiers": [{"i": "GO:0030545", "l": "signaling receptor regulator activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005021", "l": "vascular endothelial growth factor-activated receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433961", "l": "Activated TLR homo- or heterodimer recruits adaptors TIRAP(or MAL) and MyD88 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50922", "l": "chromopyrrolate + H(+) + 2 H2O + NH4(+) => 2 2-iminio-3-(indol-3-yl)propanoate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44732", "l": "2-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35930", "l": "paromamine + UDP-alpha-D-glucose <=> 3''-deamino-3''-hydroxykanamycin C + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63096", "l": "ilicicolin A epoxide = ilicicolin C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42417", "l": "a ubiquinone + L-proline => (S)-1-pyrroline-5-carboxylate + a ubiquinol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37359", "l": "D-glucosamine(out) + N(pros)-phospho-L-histidyl-[protein] = D-glucosamine 6-phosphate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.17", "l": "\"Tryptophanyl aminopeptidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050128", "l": "N-feruloylglycine deacylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649393", "l": "ERBB2 KD mutants bind trastuzumab (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18340", "l": "D-ribose 5-phosphate + uracil <=> H2O + psi-UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.265", "l": "\"Phosphatidylinositol dimannoside acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.256", "l": "\"N-terminal methionine N(alpha)-acetyltransferase NatC\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10077", "l": "H2O + lactose => D-galactose + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-888589", "l": "Release of GABA at the synapse (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33067", "l": "(4R)-hydroxysphinganine 1-phosphate + H2O = (4R)-hydroxysphinganine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13660", "l": "acetyl-[citrate lyase ACP] + H2O <=> acetate + H(+) + holo-[citrate lyase ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28388", "l": "di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170156", "l": "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47775", "l": "a guanosine in 21S rRNA + S-adenosyl-L-methionine <=> a 2'-O-methylguanosine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12438", "l": "CoA + H(+) + N-caffeoylputrescine => (E)-caffeoyl-CoA + putrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64118", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24356", "l": "a 1-acyl-sn-glycero-3-phosphocholine = a 2-acyl-sn-glycero-3-phosphocholine"}, {"i": "EC:5.4.1.1", "l": "\"Lysolecithin acylmutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424484", "l": "Phosphorylation of BTK by p-SYK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.345", "l": "\"D-2-hydroxyacid dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48448", "l": "H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047241", "l": "lipopolysaccharide N-acetylmannosaminouronosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16411", "l": "H(+) + NADPH + vomilenine => 1,2-dihydrovomilenine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45066", "l": "ethanolamine + hexadecanoate => H2O + N-hexadecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44418", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30939", "l": "ATP + dIDP = ADP + dITP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52516", "l": "trans-4-hydroxy-L-proline + ubiquinone-10 = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + H(+) + ubiquinol-10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62367", "l": "FMNH2 + O2 + thymine <=> (Z)-2-methylureidoacrylate + FMN-N(5)-oxide + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047492", "l": "xanthan lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237140", "l": "Dehydration of methylthio-ribulose-P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12390", "l": "2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => formononetin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004369", "l": "glycerol-3-phosphate oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426032", "l": "DAG is metabolized by DAGL to 2-AG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928631", "l": "GIT1 binds bPIX (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28029", "l": "[thioredoxin]-disulfide + dUDP + H2O <=> [thioredoxin]-dithiol + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690152", "l": "USP5 cleaves polyubiquitin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102993", "l": "linolenate delta15 desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706399", "l": "RHOBTB3 hydrolyzes ATP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27643", "l": "adenosine + phosphate => adenine + alpha-D-ribose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5651828", "l": "PARG dePARylates PARP1,PARP2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10961", "l": "(S)-lactate => (R)-lactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28412", "l": "4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADPH => 4-(gamma-L-glutamylamino)butanal + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12098", "l": "benzylamine + formate => H2O + N-benzylformamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51066", "l": "adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate => 3'-phosphoadenylyl sulfate + lithocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168862", "l": "Association of HA into rafts (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28504", "l": "H(+) + NADH + S-formylmycothiol => NAD(+) + S-(hydroxymethyl)mycothiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2002401", "l": "Association of procollagen type XVIII (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158925", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65428", "l": "deamido-NAD(+)(in) + NAD(+)(out) = deamido-NAD(+)(out) + NAD(+)(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099615", "l": "(D)-2-hydroxyglutarate-pyruvate transhydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209925", "l": "DIT and MIT combine to form triiodothyronine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:1990817", "l": "RNA adenylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45260", "l": "tetracosanoate(out) = tetracosanoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374663", "l": "DCC interaction with Ezrin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32644", "l": "2 [Fe(III)cytochrome c] + H2O + lupanine => 17-hydroxylupanine + 2 [Fe(II)cytochrome c] + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56241", "l": "1,2-dioctanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => 2-octanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl octanoate + apo--[retinol-binding protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29597", "l": "H(+) + NADPH + sulfoacetyl-CoA => CoA + NADP(+) + sulfoacetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192315", "l": "Bile salts are translocated from the peroxisomal matrix to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49040", "l": "(-)-5'-demethylyatein + S-adenosyl-L-methionine = (-)-yatein + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.330", "l": "\"5'-demethylyatein 5'-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47815", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-phosphate + NADPH + O2 <=> 9-ribosyl-trans-zeatin 5'-phosphate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14217", "l": "[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669240", "l": "FLNA binds PAK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0034328", "l": "decanoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9674093", "l": "PDGFRs bind type I TKI (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38134", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol <=> 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35574", "l": "(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] <=> (1'S,5'S)-5'-hydroxyaverantin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610726", "l": "The IFT-A complex recruits TULP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17260", "l": "O2 + reduced [NADPH--hemoprotein reductase] + vinorine <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + vomilenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62198", "l": "2 [Fe(II)cytochrome c] + acetone + 2 H(+) => 2 [Fe(III)cytochrome c] + propan-2-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418082", "l": "Dissociation of telomerase RNP from the extended chromosomal end (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15349", "l": "L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate"}, {"i": "EC:2.3.1.35", "l": "\"Glutamate N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34747", "l": "15-methylhexadecasphinganine + ATP = 15-methylhexadecasphinganine 1-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400204", "l": "PPARA binds RXRA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24949", "l": "3-hydroxy-3-methylglutarate + malonyl-CoA => (3S)-hydroxy-3-methylglutaryl-CoA + malonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14240", "l": "10-deoxysarpagine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sarpagine"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0005030", "l": "neurotrophin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41372", "l": "1-O-dodecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-dodecyl-sn-glycero-3-phosphocholine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18451", "l": "AH2 + arsenate + H(+) => A + arsenite + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0071553", "l": "G protein-coupled pyrimidinergic nucleotide receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58538", "l": "CoA + H(+) + N-hexadecanoylglycine => glycine + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24525", "l": "20-oxo-5-O-beta-D-mycaminosyltylonolide + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 5-O-beta-D-mycaminosyltylonolide + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50364", "l": "(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-nandinine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.19.73", "l": "\"(S)-nandinine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61213", "l": "myricetin + UDP-alpha-D-glucose => H(+) + myricetin 3-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36199", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-sn-glycerol + H(+) + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950271", "l": "sIL27RA translocates from the cytoplasm to the extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0055106", "l": "ubiquitin-protein transferase regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.307", "l": "\"D-xylose reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382058", "l": "Nck binds to the active PDGF receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12541", "l": "ATP + L-alanine + tRNA(Ala) => AMP + diphosphate + L-alanyl-tRNA(Ala)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38146", "l": "carbon disulfide + 2 H2O <=> CO2 + 2 H(+) + 2 hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66015", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + hypobromite + L-methionyl-[collagen] <=> [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16915", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+) => a CDP-1,2-diacyl-sn-glycerol + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024361", "l": "Expression of ABCG1 regulated by NR1H2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70486", "l": "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41194", "l": "1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20820", "l": "choline sulfate + H2O = choline + H(+) + sulfate"}, {"i": "EC:3.1.6.6", "l": "\"Choline-sulfatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48513", "l": "ATP + H2O + phosphinate(out) => ADP + H(+) + phosphate + phosphinate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2129375", "l": "Elastin cross-linking by lysyl oxidase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4655374", "l": "SUMOylation of DNMT3B with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56508", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043730", "l": "5-ureido-4-imidazole carboxylate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034871", "l": "1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9008043", "l": "MAPK8 phosphorylation (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862771", "l": "PLA2G2A binds bacterial phospholipids (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19759", "l": "NH4(+) + oxaloacetate => (3R)-3-hydroxy-L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1362416", "l": "Frataxin binds iron (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473184", "l": "Follistatin (FST) binds Activin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50525", "l": "acetyl-CoA + N-terminal L-methionyl-L-isoleucyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437984", "l": "Phosphorylation of MKK3/MKK6 by activated TAK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052687", "l": "(3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity"}, {"i": "KEGG.REACTION:R06396"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-879459", "l": "F-actin capping protein is a heterodimer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "80.661393760018115", "identifiers": [{"i": "GO:0033558", "l": "protein deacetylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59644", "l": "D-xylobiono-1,5-lactone + H2O = D-xylobionate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20427", "l": "(S)-oxalosuccinate + ADP + H(+) + phosphate => 2-oxoglutarate + ATP + hydrogencarbonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607733", "l": "BCL10 binds CARD9 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55717", "l": "(S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(2'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O => (9Z)-octadecenoate + (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45975", "l": "3-oxochol-4-en-22-oate + H(+) + NADH + O2 <=> 9alpha-hydroxy-3-oxochol-4-en-22-oate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5681987", "l": "LC3 is cleaved by ATG4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65886", "l": "H2O + L-glutamate + xanthurenate => 2-oxoglutarate + 3-hydroxy-L-kynurenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63277", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 => a 1-acyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64846", "l": "(2E)-geranyl benzoate + CoA => (2E)-geraniol + benzoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938887", "l": "PML binds RUNX1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51018", "l": "6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde phosphate => 7,8-dihydroneopterin 3'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64196", "l": "an N-(fatty acyl)-L-lysine + H2O = a fatty acid + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30553", "l": "6-O-acetyl-beta-D-glucose + CoA => acetyl-CoA + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20220", "l": "H(+) + trimethylamine N-oxide <=> dimethylamine + formaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71783", "l": "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166015", "l": "Association of LBP with LPS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603467", "l": "Activated protein C is released from PROCR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42156", "l": "3alpha-hydroxy-5alpha-androstan-17-one + H(+) + NADPH = 5alpha-androstane-3alpha,17beta-diol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71825", "l": "G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30080", "l": "ATP + CoA + crotonobetaine => AMP + crotonobetainyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102569", "l": "FR-33289 synthase activity"}, {"i": "MetaCyc:RXN-15082"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731147", "l": "Syndecan-4 binds PI(4,5)P2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36019", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624949", "l": "Assembly of the anterograde IFT train (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009044", "l": "xylan 1,4-beta-xylosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66308", "l": "an inositol-1-phosphoceramide + GDP-alpha-D-mannose = an alpha-mannosylinositol-1-phosphoceramide + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11269", "l": "D-cysteine + H2O => H(+) + hydrogen sulfide + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59118", "l": "[protein]-disulfide + H2O2 => [protein]-dithiol + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042163", "l": "interleukin-12 beta subunit binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37148", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2172126", "l": "DAP12 interacts with NKG2C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10972", "l": "D-hexose + H(+) + phosphoramidate = alpha-D-hexose 1-phosphate + NH4(+)"}, {"i": "EC:2.7.1.62", "l": "\"Phosphoramidate--hexose phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015108", "l": "chloride transmembrane transporter activity"}, {"i": "MetaCyc:3.6.3.11-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37770", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36386", "l": "carbamoyl adenylate + tobramycin <=> AMP + H(+) + nebramycin 5'"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11135", "l": "chlorophyllide a + NADP(+) <=> H(+) + NADPH + protochlorophyllide a"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56821", "l": "AH2 + cyclooctat-9-en-7-ol + O2 => A + cyclooctat-9-ene-5,7-diol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693250", "l": "RHOD binds effectors at the Golgi membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-176956", "l": "Formation of GINS complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004742", "l": "dihydrolipoyllysine-residue acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38011", "l": "chlorophyll a + H2O = chlorophyllide a + H(+) + phytol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9649735", "l": "Intrinsic nucleotide exchange on RAS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44867", "l": "a triacyl-sn-glycerol + H2O <=> a 1,2-diacylglycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205075", "l": "JNK phosphorylates BIM, BAD and other targets (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-203977", "l": "SAR1 Activation And Membrane Binding (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736984", "l": "p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 binds MYC gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.3", "l": "\"Metridin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362549", "l": "Hh-Np traffics to the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140851", "l": "fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21027", "l": "CoA + glyoxylate + NADP(+) <=> H(+) + NADPH + oxalyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.5", "l": "\"Hydroxymethylglutaryl-CoA hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944225", "l": "Association of procollagen type XVII (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801637", "l": "TP53 stimulates PLK2 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797803", "l": "PTPRD binds SLITRK1-6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54033", "l": "(6S)-10-formyltetrahydrofolate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose => (6S)-5,6,7,8-tetrahydrofolate + dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46312", "l": "3-oxochol-4-en-22-oyl-CoA + acetyl-CoA = 3,22-dioxochol-4-en-24-oyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49534", "l": "ethylene glycol + H(+) + terephthalate => 4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18899", "l": "AH2 + L-thyroxine => 3,3',5'-triiodo-L-thyronine + A + H(+) + iodide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607721", "l": "Activation of NIK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44810", "l": "2-demethylmenaquinol-10 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-decaprenyl diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218814", "l": "PAK2 autophorylates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10319", "l": "2-oxoglutarate + O2 + thymine <=> 5-hydroxymethyluracil + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102088", "l": "N-(4-hydroxybenzoyl)-L-glutamate synthetase activity"}, {"i": "MetaCyc:RXN-10887"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28524", "l": "D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate => D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424482", "l": "p85 regulatory unit of PI3K binds p-6Y-SYK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-420980", "l": "Activation of Ca permeable AMPA receptors (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008832", "l": "RUNX2 binds BAX gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140343", "l": "phosphatidylserine transfer activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168140", "l": "Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40402", "l": "1,2-dihydro-beta-NADP + H(+) + O2 <=> H2O2 + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14260", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26151", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) <=> 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426489", "l": "RISC binds inexactly matching target RNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-179410", "l": "Association of Nek2A with MCC:APC/C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176318", "l": "Loading of claspin onto DNA during replication origin firing (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047098", "l": "Latia-luciferin monooxygenase (demethylating) activity"}, {"i": "MetaCyc:1.14.99.21-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102028", "l": "cystathionine gamma-synthase activity (acts on O-phosphohomoserine)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59323", "l": "D-cellobiono-1,5-lactone + H2O <=> 4-O-beta-D-glucopyranosyl-D-gluconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14406", "l": "D-glucose + NADP(+) => D-glucono-1,5-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51637", "l": "a quinone + H2O + selenite => a quinol + selenate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103058", "l": "kaempferol 3-glucoside 7-O-rhamnosyltransferase activity"}, {"i": "MetaCyc:RXN1F-443"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22132", "l": "ATP + D-maltose(out) + H2O = ADP + D-maltose(in) + H(+) + phosphate"}, {"i": "EC:7.5.2.1", "l": "\"ABC-type maltose transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43626", "l": "aminoacetaldehyde + CO2 => 2-aminomalonate semialdehyde + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016207", "l": "4-coumarate-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211959", "l": "CYP3A43 6b-hydroxylates TEST (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140517", "l": "protein-RNA adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018773", "l": "acetylpyruvate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15531", "l": "2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+) => bis(2-ethylhexyl)phthalate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710353", "l": "GSDMD (1-275) binds cardiolipin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434650", "l": "MATEs mediate extrusion of xenobiotics (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665748", "l": "FMNL2 binds RHOC:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664850", "l": "ATM binds PEX5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791131", "l": "Expression of PDIA6 (Protein disulfide-isomerase A6) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9670673", "l": "FIX is secreted (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56198", "l": "H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802933", "l": "p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56351", "l": "4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 <=> 2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004813", "l": "alanine-tRNA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623365", "l": "Expression of MYLIP regulated by NR1H2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17915", "l": "H(+) + NADH + nitrate => H2O + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797100", "l": "CCNK binds CDK13 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.49", "l": "\"Separase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781814", "l": "USP19 deubiquitinates RNF123 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66047", "l": "2-oxobutanoate + L-kynurenine <=> (2S)-2-aminobutanoate + H2O + kynurenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850794", "l": "SPINK6 binds KLK5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8957241", "l": "TP73 tetramer translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56751", "l": "an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66488", "l": "quillate + UDP-alpha-D-glucose = quillaic acid 28-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61422", "l": "cis-cis-nepetalactol => (S)-8-oxocitronellyl enol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800870", "l": "NDUF subunits bind to form the FP subcomplex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40594", "l": "decanedioyl-CoA + H2O <=> CoA + decanedioate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783530", "l": "gp130:JAKs bind CNTFR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964759", "l": "Alternative endo-mannosidase I route (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.160"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38059", "l": "2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA = 1-octanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-888577", "l": "Synthesis of GABA by GAD2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51348", "l": "acetyl-CoA + 10 AH2 + 2 H(+) + 7 malonyl-CoA + 5 S-adenosyl-L-methionine = 10 A + 7 CO2 + 8 CoA + dehydroprobetaenone I + 6 H2O + 5 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51374", "l": "CoA + H(+) + N-(9Z-hexadecenoyl)-glycine => (9Z)-hexadecenoyl-CoA + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199046", "l": "Ligands bind L-selectin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5679266", "l": "Beclin-1 complex translocates to the ER (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "66.108910517769971", "identifiers": [{"i": "GO:0008374", "l": "O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32291", "l": "phosphoethanolamine + 3 S-adenosyl-L-methionine = 3 H(+) + phosphocholine + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46153", "l": "15-cis-phytoene + a plastoquinone => 15,9'-di-cis-phytofluene + a plastoquinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61184", "l": "quercitrin + UDP-beta-L-rhamnose = H(+) + quercetin 3,7-bis-O-alpha-L-rhamnoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61997", "l": "L-lysyl-[protein] + lactoyl-CoA => CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53275", "l": "5-dehydro-L-gluconate <=> keto-D-tagaturonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36439", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21104", "l": "AH2 + cholesterol + O2 = 25-hydroxycholesterol + A + H2O"}, {"i": "EC:1.14.99.38", "l": "\"Cholesterol 25-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31309", "l": "alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60308", "l": "L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine = 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.357", "l": "\"[Histone H3]-lysine(36) N-dimethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34737", "l": "an N-acylsphinganine + CoA + H(+) => a fatty acyl-CoA + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20742", "l": "(2R,3S)-tartrate => H2O + trans-2,3-epoxysuccinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9626848", "l": "S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6801195", "l": "STEAP3 binds BNIP3L (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602458", "l": "Activation of proMMP10 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854209", "l": "TBC1D10A binds JFC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047389", "l": "glycerophosphocholine phosphodiesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18018", "l": "H(+) + indole-3-pyruvate => CO2 + indole-3-acetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050388", "l": "uronate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692934", "l": "BACE1 binds GGA1,2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23130", "l": "4-hydroxybutanoyl-CoA + AMP + diphosphate => 4-hydroxybutanoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17344", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) <=> 1-hexadecanoylglycerone 3-phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62904", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc derivative + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654399", "l": "Activated FGFR2 binds FRS2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29137", "l": "a menaquinone + 2 H(+)(out) + H2O + nitrite => a menaquinol + 2 H(+)(in) + nitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45666", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9017491", "l": "RHOJ GEFs activate RHOJ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14700", "l": "(2E,6E)-farnesol + NADP(+) <=> (2E,6E)-farnesal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75856", "l": "Abortive Initiation Before Second Transition (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3239014", "l": "MAPKAPK5 phosphorylates TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55415", "l": "[phosphate](n) + GTP <=> [phosphate](n+1) + GDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030758", "l": "3,7-dimethylquercitin 4'-O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19613", "l": "dimethyl sulfide + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + trimethylsulfonium"}, {"i": "EC:2.1.1.96", "l": "\"Thioether S-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420274", "l": "GIP receptor binds gastric inhibitory peptide (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975594", "l": "PLB1 hydrolyses RPALM to atROL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33154", "l": "(R)-dihydrolipoamide + acetyl-CoA <=> (R)-S(6)-acetyldihydrolipoamide + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451858", "l": "YKI binds to HPO homodimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191402", "l": "Reduction of presqualene diphosphate to form squalene (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39325", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+) => (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54468", "l": "1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429157", "l": "ABCC4 accumulation of dense granule contents (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39059", "l": "26-hydroxyhexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 26-oxohexacosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9674531", "l": "AAMP binds EGFR (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.27", "l": "\"Choloyl-CoA hydrolase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990226", "l": "histone methyltransferase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43875", "l": "3-oxochol-4-en-22-oate + ATP + CoA <=> 3-oxochol-4-en-22-oyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655193", "l": "KIAA0101 double monoubiquitination (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32039", "l": "H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = AMP + ATP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944236", "l": "Association of procollagen type XIV (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44816", "l": "1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+) = 2-demethylmenaquinol-12 + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47860", "l": "ganglioside GT1b (d18:1(4E)) + H2O = ganglioside GD1b (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606312", "l": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73757", "l": "Binding of RRN3 to RNA Polymerase I (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875523", "l": "MET binds TNS3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62524", "l": "cytidine(839) in 12S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70486", "l": "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445079", "l": "Phosphorylation of L1 by ERK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168982", "l": "Collagen type XVI degradation by MMP9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38690", "l": "(4R)-hydroxysphinganine(in) + ATP + H2O <=> (4R)-hydroxysphinganine(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38386", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27590", "l": "(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + ADP + H(+) + phosphate"}, {"i": "EC:6.3.2.44", "l": "\"Pantoate--beta-alanine ligase (ADP-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034861", "l": "benzothiazole-2-sulfonate hydrolase activity"}, {"i": "EC:3.13.1.-", "l": "\"Acting on carbon-sulfur bonds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661217", "l": "MT1A binds zinc (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392295", "l": "Gbeta:gamma recruits PI3K gamma (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5658430", "l": "NF1 is degraded by the proteasome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3095901", "l": "ABCC1 transports cytosolic Cbl to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10136", "l": "2 glyoxylate + H(+) = 2-hydroxy-3-oxopropanoate + CO2"}, {"i": "EC:4.1.1.47", "l": "\"Tartronate-semialdehyde synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3899291", "l": "SUMOylation of EP300 with SUMO1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38871", "l": "uridine(2457) in 23S rRNA = pseudouridine(2457) in 23S rRNA"}, {"i": "EC:5.4.99.20", "l": "\"23S rRNA pseudouridine(2457) synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658104", "l": "SNCAIP binds alpha-synuclein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114544", "l": "p115-RhoGEF activation of RHOA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853762", "l": "RET dimerizes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004989", "l": "octopamine receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52658", "l": "a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH => a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46747", "l": "ATP + hydrogencarbonate <=> ADP + carboxyphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198314", "l": "DAG stimulates protein kinase C-delta (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-706479", "l": "TAK1 is activated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50772", "l": "H2O + nitroethane + O2 = acetaldehyde + H(+) + H2O2 + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33204", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51916", "l": "(2S)-2-amino-3-butenoate + H2O = 2-oxobutanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444647", "l": "C3a receptor binds anaphylatoxin C3a (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56243", "l": "1,2-dioctanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> 2-octanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl octanoate + apo--[retinol-binding protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019962", "l": "type I interferon binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033924", "l": "dextran 1,6-alpha-isomaltotriosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9632182", "l": "PRMT1 methylates ESRs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35313", "l": "3-oxoisoheptadecanoyl-CoA + H(+) + NADPH => 3-hydroxyisoheptadecanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249392", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004120", "l": "photoreceptor cyclic-nucleotide phosphodiesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62596", "l": "(S)-8-oxocitronellyl enol + NAD(+) = (6E)-8-oxogeranial + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45151", "l": "3-(methylsulfanyl)acryloyl-CoA + H2O <=> 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15341", "l": "ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide = ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate"}, {"i": "EC:6.6.1.2", "l": "\"Cobaltochelatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21586", "l": "H(+) + hydroxyacetone phosphate + NADH => NAD(+) + propane-1,2-diol 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51474", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010472", "l": "GDP-galactose:glucose-1-phosphate guanylyltransferase activity"}, {"i": "MetaCyc:RXN4FS-13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6790038", "l": "Expression of HSP90B1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4332363", "l": "Autophosphorylation and activation of CAMK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.17", "l": "\"4-hydroxy-4-methyl-2-oxoglutarate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190256", "l": "FGFR1c binds to FGF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41503", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004585", "l": "ornithine carbamoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641147", "l": "DACT1 binds DVL2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0099099", "l": "G-protein gated ion channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25930", "l": "3-methylquinolin-2(1H)-one + AH2 => 3-methylquinoline + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5336443", "l": "LIN7, CASK and APBA1 bind (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16570", "l": "2-oxoglutarate + L-lysyl-[collagen] + O2 => (5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49978", "l": "adenosine 3',5'-bisphosphate + butanoyl-4'-phosphopantetheine + 2 H(+) => butanoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443439", "l": "c-Src binds Raf1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659879", "l": "Defective SI does not hydrolyze iMal (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13495", "l": "(S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH => (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11404", "l": "UDP-alpha-D-glucuronate = UDP-alpha-D-galacturonate"}, {"i": "EC:5.1.3.6", "l": "\"UDP-glucuronate 4-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.371", "l": "\"Polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 2,3-alpha-mannosylpolymerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18676", "l": "ATP + L-seryl-[receptor-protein] <=> ADP + H(+) + O-phospho-L-seryl-[receptor-protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66300", "l": "an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose = an alpha-D-mannosylinositol-1-phosphodihydroceramide + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16481", "l": "3 S-adenosyl-L-methionine = 3 H(+) + nicotianamine + 3 S-methyl-5'-thioadenosine"}, {"i": "EC:2.5.1.43", "l": "\"Nicotianamine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46480", "l": "4alpha-formyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 = 4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55726", "l": "17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+) => 17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21019", "l": "H2O + L-asparagine <=> L-aspartate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61041", "l": "(+)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] => (+)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34260", "l": "(+)-larreatricin + AH2 + O2 => (+)-3'-hydroxylarreatricin + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70577", "l": "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41020", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol => 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60307", "l": "N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047719", "l": "indole 2,3-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198508", "l": "malate + NAD+ <=> oxaloacetate + NADH + H+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237129", "l": "Acireductone is created (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37463", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047174", "l": "putrescine N-hydroxycinnamoyltransferase activity"}, {"i": "MetaCyc:2.3.1.138-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1606583", "l": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45641", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39314", "l": "(8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32892", "l": "(1S,5S)-alpha-pinene + H(+) + NADH + O2 => alpha-pinene oxide + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19606", "l": "a chlorophyll + H2O => a chlorophyllide + H(+) + phytol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43972", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = H(+) + hexadecanoate + hexadecanoyl-glycero-3-phospho-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57588", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-2-hydroxynaringenin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17075", "l": "CoA + cortisol 21-acetate => acetyl-CoA + cortisol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167191", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.19", "l": "\"Steroid 17-alpha-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48545", "l": "[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine => [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57582", "l": "S-methyl-1-thiol-D-ribulose 5-phosphate => S-methyl-5-thio-D-ribulose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050030", "l": "L-pipecolate dehydrogenase activity"}, {"i": "RHEA:19777", "l": "A + L-pipecolate = AH2 + H(+) + L-1-piperideine-6-carboxylate"}, {"i": "EC:1.5.99.3", "l": "\"L-pipecolate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20520", "l": "UDP-N-acetyl-alpha-D-glucosamine <=> UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004147", "l": "dihydrolipoamide branched chain acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35496", "l": "H2O + N-(4-aminobenzoyl)-L-glutamate => 4-aminobenzoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39669", "l": "a ketone + reduced coenzyme F420-(gamma-Glu)(n) => a secondary alcohol + H(+) + oxidized coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59849", "l": "(2R,3S)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH => (S)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030196", "l": "cyanide hydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30641", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+) => (R)-glycerate + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55306", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656254", "l": "Defective OGG1 mutants show decreased binding to 8-oxoguanine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422088", "l": "Expression of Preproghrelin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32462", "l": "2 S-adenosyl-L-methionine + uroporphyrinogen III <=> H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49254", "l": "D-fructose 1-phosphate(in) + L-histidyl-[protein] => D-fructose(out) + N(pros)-phospho-L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446372", "l": "Association of  PARVA with TESK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31499", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP"}, {"i": "EC:2.4.1.275", "l": "\"Neolactotriaosylceramide beta-1,4-galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58854", "l": "(6E)-8-oxogeranial + H(+) + NADH => (6E)-8-oxogeraniol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358790", "l": "RNF41 ubiquitinates ERBB3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.9", "l": "\"Agaritine gamma-glutamyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45889", "l": "12-methyltridecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(11-methyldodecyl)-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.-", "l": "\"Hydroxylases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010643", "l": "AKAP5 recruits PKC to ROBO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2509827", "l": "ITPA hydrolyses ITP to IMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23115", "l": "6-methylsalicylate + H(+) <=> 3-methylphenol + CO2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015389", "l": "pyrimidine- and adenine-specific:sodium symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23975", "l": "(2E)-glutaconyl-CoA + H(+) + Na(+)(in) <=> (2E)-butenoyl-CoA + CO2 + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41791", "l": "acetyl-CoA + holo-[ACP] <=> acetyl-[ACP] + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4411383", "l": "NLK phosphorylates TCF/LEF (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014296", "l": "RAC2 GEFs activate RAC2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36366", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 H(+) + 2 NADPH <=> (9Z,12Z)-octadecadien-1-ol + CoA + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11485", "l": "2 [Fe(III)cytochrome c](out) + a quinol => 2 [Fe(II)cytochrome c](out) + a quinone + 2 H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67033", "l": "4,8-dihydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] => 4,5,8-trihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008123", "l": "cholesterol 7-alpha-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656207", "l": "CR2 RAF1 mutants don't bind YWHAB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013159", "l": "CDC42 GEFs activate CDC42 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32385", "l": "(1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH => (1S,2S,4R)-limonene-1,2-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52043", "l": "L-cystine <=> 2-aminoprop-2-enoate + S-sulfanyl-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391377", "l": "Luteinizing hormone receptor can bind LH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38257", "l": "(S)-malyl-CoA + succinate => (S)-malate + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12916", "l": "(R)-lipoate + ATP + H(+) <=> (R)-lipoyl-5'-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32224", "l": "(6S)-NADHX + ADP => AMP + H(+) + NADH + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000810", "l": "diacylglycerol diphosphate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16331", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35377", "l": "(beta-L-Ara4N)2-(Kdo)2-lipid A(out) + ADP + H(+) + phosphate => (beta-L-Ara4N)2-(Kdo)2-lipid A(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948775", "l": "MKRN1 polyubiquitinates PTEN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56848", "l": "1,6-didemethyltoxoflavin + S-adenosyl-L-methionine = H(+) + reumycin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57126", "l": "2-hydroxy-5-oxoproline => 2-oxoglutaramate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47805", "l": "epothilone C + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => epothilone A + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59293", "l": "beta-D-galactosyl-(1<->1')-N-octadecanoylsphing-4-enine + H2O => D-galactose + N-octadecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19355", "l": "cholate + glycine => glycocholate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9676071", "l": "CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6781840", "l": "ERCC6 binds stalled RNA Pol II (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10908", "l": "3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52136", "l": "guanosine-5'-diphospho-5'-(DNA) + H2O = GMP + 2 H(+) + phospho-5'-(DNA)"}, {"i": "EC:3.6.1.70", "l": "\"Guaosine-5'-diphospho-5'-(DNA) diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373717", "l": "DCC interacts with DIP13alpha (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60923", "l": "2-oxoglutarate + an N(3)-methylcytidine in mRNA + O2 <=> a cytidine in mRNA + CO2 + formaldehyde + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350058", "l": "Formation of CSL NCOR corepressor complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24137", "l": "3'-phosphoadenylyl sulfate + a primary amine => a sulfamate + adenosine 3',5'-bisphosphate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982778", "l": "Growth hormone binds the growth hormone receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55787", "l": "all-trans-4-oxoretinoate + UDP-alpha-D-glucuronate <=> all-trans-4-oxoretinoate 1-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029273", "l": "PI3K binds to p-6Y-SYK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.67", "l": "\"Cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31292", "l": "(S)-malate + FAD + H(+) => FADH2 + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807496", "l": "POU2F1 (OCT1) or POU2F2 (OCT2), SP1, and ZNF143 (STAF) bind the DSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16638", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine => [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507871", "l": "Aquaporins passively transport glycerol out of cells (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28486", "l": "Fe(2+)(in) = Fe(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43466", "l": "(2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.8", "l": "\"Clostripain\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58713", "l": "NADH + O2 + rifampicin => H(+) + H2O + NAD(+) + rifampicin para-naphthoquinone carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14705", "l": "2 CoA + NADP(+) = CoA-disulfide + H(+) + NADPH"}, {"i": "EC:1.8.1.14", "l": "\"CoA-disulfide reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419334", "l": "Melatonin receptors can bind melatonin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112437", "l": "Formation of NELF complex  (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050582", "l": "xylitol oxidase activity"}, {"i": "MetaCyc:1.1.3.41-RXN"}, {"i": "EC:1.1.3.41", "l": "\"Alditol oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62346", "l": "diphosphate + notoamide S => 6-hydroxydeoxybrevianamide E + dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46247", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 <=> (14E)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710263", "l": "GZMB cleaves GSDME (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61106", "l": "(2S)-dihydrotricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (2S)-naringenin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451309", "l": "Edited Kainate Receptor binds glutamate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41843", "l": "3-oxooctanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyoctanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35710", "l": "(2S)-versicolorone + H(+) + NADPH + O2 <=> (3S)-versiconol acetate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0023023", "l": "MHC protein complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112396", "l": "Separation of elongating transcript from template (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047978", "l": "hexadecanol dehydrogenase activity"}, {"i": "MetaCyc:HEXADECANOL-DEHYDROGENASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134883", "l": "Beta-catenin enhances association of IRF3 with CBP/p300  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204169", "l": "PDP dephosphorylates p-lipo-PDH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39037", "l": "an omega-oxo fatty acid + H(+) + NADH => an omega-hydroxy fatty acid + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161293", "l": "Tropoelastin forms aggregate globules (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61111", "l": "(2R,3R)-dihydrokaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (2R,3R)-dihydromyricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203567", "l": "palmitoylation of eNOS (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64948", "l": "dCTP + H2O = dCDP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004686", "l": "elongation factor-2 kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14564", "l": "(E,E)-piperoyl-CoA + piperidine <=> CoA + H(+) + N-[(E,E)-piperoyl]piperidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19415", "l": "AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe) => ATP + L-phenylalanine + tRNA(Phe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033200", "l": "inositol heptakisphosphate 5-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66865", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + quiannulatene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10724", "l": "GDP-6-deoxy-alpha-D-talose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028598", "l": "Phosphorylation of YAP by LATS1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003833", "l": "beta-alanyl-dopamine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65027", "l": "7alpha-hydroxy-3,12-dioxo-5beta-cholanate + NADP(+) <=> dehydrocholate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51233", "l": "2-glyceryl-prostaglandin H2 => 2-glyceryl-prostaglandin D2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604732", "l": "Autocatalytic activation of proMMP13 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70899", "l": "histidine => urocanate + NH4+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5228508", "l": "RANBP2 SUMOylates PML with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40183", "l": "O2 + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45585", "l": "3-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975633", "l": "atROL binds to RBP2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43175", "l": "guanosine(1575) in yeast 18S rRNA + S-adenosyl-L-methionine <=> N(7)-methylguanosine(1575) in yeast 18S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983872", "l": "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13155", "l": "2-hydroxy-3-oxosuccinate + 2 H(+) + NADH => (R)-glycerate + CO2 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56868", "l": "(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA = (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA"}, {"i": "EC:2.3.1.273", "l": "\"Diglucosylglycerate octanoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604738", "l": "Active FLT3 dimer binds GRB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65609", "l": "(4R)-hydroxysphinganine + docosanoyl-CoA => CoA + H(+) + N-docosanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682598", "l": "ATM phosphorylates HERC2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008822", "l": "PPM1D dephosphorylates RUNX2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.62", "l": "\"5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375131", "l": "Basigin binds CD98 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001084", "l": "L-arabinofuranose binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66432", "l": "H(+)(out) + L-galactose(out) = H(+)(in) + L-galactose(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-888577", "l": "Synthesis of GABA by GAD2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621054", "l": "REST binds the VGF promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169402", "l": "ISGylation of E2 conjugating enzymes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32401", "l": "(1S,4S)-dihydrocarvone + H(+) + NADH => (1S,2R,4S)-neodihydrocarveol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015275", "l": "stretch-activated, cation-selective, calcium channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-481007", "l": "Exocytosis of platelet alpha granule contents (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8938773", "l": "RNF144A polyubiquitinates PRKDC (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22047", "l": "ATP + H(+)(in) + H2O + K(+)(out) <=> ADP + 2 H(+)(out) + K(+)(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57371", "l": "H2O + NADPH <=> (6R)-NADPHX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55903", "l": "chloride + FADH2 + L-tryptophan + O2 <=> 6-chloro-L-tryptophan + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088264", "l": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2152276", "l": "Secretion of transmembrane collagens (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57380", "l": "(S)-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] = (13S,14R)-1,13-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.163", "l": "\"(S)-1-hydroxy-N-methylcanadine 13-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17716", "l": "(R)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + salutaridine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975633", "l": "atROL binds to RBP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59846", "l": "(R)-isodihydrodehydrodiconiferyl alcohol + NADP(+) => (+)-dehydrodiconiferyl alcohol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668597", "l": "DNA polymerase:primase binds G-strand of the telomere (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28511", "l": "arbutin 6-phosphate + H2O => beta-D-glucose 6-phosphate + hydroquinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800298", "l": "HGF dimer binds MET (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60679", "l": "(S)-(-)-citronellol + NAD(+) <=> (S)-(-)-citronellal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58370", "l": "(2E,6Z)-nona-2,6-dienal + H(+) + NADPH => (2E,6Z)-nona-2,6-dien-1-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49127", "l": "H(+) + NADPH + O2 + protodeoxyviolaceinate <=> H2O + NADP(+) + protoviolaceinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65101", "l": "a 1-acylglycerol + hexadecanoyl-CoA => an hexadecanoyl-acylglycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45793", "l": "2-oxoglutarate + [ribosomal protein S23]-L-proline + O2 => [ribosomal protein S23]-trans-3-hydroxy-L-proline + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047061", "l": "glucose-fructose oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009924", "l": "octadecanal decarbonylase activity"}, {"i": "RHEA:21440", "l": "a long-chain fatty aldehyde + H(+) + 2 NADPH + O2 = a long-chain alkane + formate + H2O + 2 NADP(+)"}, {"i": "RHEA:30415", "l": "H(+) + 2 NADPH + O2 + octadecanal = formate + H2O + heptadecane + 2 NADP(+)"}, {"i": "EC:4.1.99.5", "l": "\"Aldehyde oxygenase (deformylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9710106", "l": "ELANE cleaves GSDMD (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40181", "l": "(2E)-decenoyl-CoA + H2O2 => decanoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41356", "l": "bacteriochlorophyll a + 3 NADP(+) = geranylgeranyl-bacteriochlorophyllide a + 3 H(+) + 3 NADPH"}, {"i": "EC:1.3.1.111", "l": "\"Geranylgeranyl-bacteriochlorophyllide a reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29971", "l": "2'-deoxyinosine(in) + H(+)(in) = 2'-deoxyinosine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941312", "l": "ZCCHC6, ZCCHC11 are mRNA uridyltransferases (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375135", "l": "Basigin binds Matrix metalloproteinase-1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10473", "l": "(2R,3S)-2,3-dimethylmalate => propanoate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38607", "l": "2'-phospho-cyclic ADP-ribose + nicotinate = nicotinate-adenine dinucleotide phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65400", "l": "butan-1-ol + butanoyl-CoA = butyl butanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30074", "l": "acetyl-CoA + butanoate <=> acetate + butanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67021", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26141", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + H2O => 5-amino-6-(5-phospho-D-ribitylamino)uracil + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102312", "l": "4-coumaroyl 2'-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613644", "l": "SOX10-dependent POU3F1 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010539", "l": "SLIT2 gene expression is stimulated by ISL1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41727", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (11R)-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-936963", "l": "IRAK2 induces TRAF6 oligomerization (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32135", "l": "2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29110", "l": "H(+) + NADH + ubiquinone-8 <=> NAD(+) + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381706", "l": "GLP1R:GLP1 activates G(s) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68954", "l": "Mcm2-7 is phosphorylated by DDK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70573", "l": "argininosuccinate <=> fumarate + arginine (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102878", "l": "(+)-alpha-barbatene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47376", "l": "(25R)-3beta,26-dihydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxycholest-5-en-7-one-26-al + 2 H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12839", "l": "ADP + H(+) + phosphocholine => ATP + choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034387", "l": "4-aminobutyrate:pyruvate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23803", "l": "H2O + L-methionine <=> 2-oxobutanoate + methanethiol + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351936", "l": "Caspase-mediated cleavage of claspin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31138", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + diphosphate <=> 5-amino-4-imidazolecarboxyamide + 5-phospho-alpha-D-ribose 1-diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48107", "l": "N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48222", "l": "(2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + tricosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17680", "l": "2-(acetamidomethylene)-3-(hydroxymethyl)succinate + H(+) + 2 H2O <=> 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41335", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211219", "l": "Translocation of caspase-3 to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399981", "l": "AKT1 E17K mutant phosphorylates MDM2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5632652", "l": "Hh-Npp binds CDON and PTCH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31706", "l": "2 H(+) + O2 + pentalenene + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2691226", "l": "NOTCH1 HD domain mutants bind JAG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14194", "l": "3-hydroxybenzoate + AH2 + O2 => 2,3-dihydroxybenzoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710295", "l": "IRF2 or IRF1 binds the GSDMD gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168136", "l": "Activated JNKs phosphorylate c-JUN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36112", "l": "gibberellin A1 + S-adenosyl-L-methionine => O-methyl gibberellin A1 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088130", "l": "PLK1 binds FOXM1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57165", "l": "2-oxoglutarate + L-arginyl-[RCC1 domain-containing protein] + O2 => (3R)-3-hydroxy-L-arginyl-[RCC1 domain-containing protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36166", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate <=> ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674093", "l": "PDGFRs bind type I TKI (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45354", "l": "9,10-dihydroxyoctadecanoate => 9,10-epoxyoctadecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25975", "l": "H2O + N(8)-acetylspermidine + O2 <=> 4-acetamidobutanal + H2O2 + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60473", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) + 5-formyltetrahydrofolate(out) => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) + 5-formyltetrahydrofolate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-500708", "l": "GRIK3 homomer binds glutamate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690023", "l": "NUBPL binds 4Fe-4S (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810161", "l": "HOXA3 chromatin is activated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612246", "l": "ERBB4s80 binds the APOE gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004026", "l": "alcohol O-acetyltransferase activity"}, {"i": "MetaCyc:ALCOHOL-O-ACETYLTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102483", "l": "scopolin beta-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50312", "l": "2-oxopentanoate + H(+) = butanal + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21585", "l": "NAD(+) + propane-1,2-diol 1-phosphate => H(+) + hydroxyacetone phosphate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45752", "l": "(3E)-decenoyl-CoA = (2E)-decenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376122", "l": "DSCAM/DSCAML1 homodimerization (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110244", "l": "Excision of FapyG by OGG1 glycosylase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11149", "l": "4 Fe(2+) + 4 H(+) + O2 => 4 Fe(3+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218828", "l": "PTK2/SRC-1 phosphorylates BCAR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016005", "l": "phospholipase A2 activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110307", "l": "REV1 binds AP-dsDNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15051", "l": "D-glucose + GDP + H(+) => GDP-alpha-D-glucose + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070653", "l": "high-density lipoprotein particle receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58121", "l": "ATP + L-seryl-[protein] => 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43249", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654159", "l": "Activated FGFR2 binds PLCG1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419428", "l": "S1PR2-5 bind S1P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700120", "l": "PTN and MDK bind to PTPRZ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014296", "l": "RAC2 GEFs activate RAC2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51641", "l": "(9Z,12Z)-octadecadienoate + O2 => (11R)-hydroperoxy-(9Z,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76416", "l": "Benzene is hydroxylated to phenol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047027", "l": "benzyl-2-methyl-hydroxybutyrate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73945", "l": "FAS-mediated dimerization of procaspase-8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17021", "l": "(2-aminoethyl)phosphonate + pyruvate = L-alanine + phosphonoacetaldehyde"}, {"i": "EC:2.6.1.37", "l": "\"2-aminoethylphosphonate--pyruvate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42002", "l": "H(+) + isogloboside iGb3Cer (d18:1(4E)) + UDP => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3318415", "l": "ATF2 acetylates histone H2B, H4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42676", "l": "L-cysteine + L-histidine + O2 = H2O + L-alanin-3-yl L-histidin-5-yl sulfoxide"}, {"i": "EC:1.14.99.52", "l": "\"L-cysteinyl-L-histidinylsulfoxide synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57190", "l": "glycolate + H(+) + L-arginyl-[protein] => H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663258", "l": "NR1D1 (REV-ERBA) binds heme, the PPARGC1A gene, and recruits corepressors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-112429", "l": "Formation of FACT complex (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102146", "l": "tricetin O-methytransferase activity"}, {"i": "RHEA:27493", "l": "S-adenosyl-L-methionine + tricetin = 3'-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine"}, {"i": "MetaCyc:RXN-11582"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46904", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A hexaacyl 1-(2-aminoethyl diphosphate) = a 1,2-diacyl-sn-glycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617832", "l": "FOXO4:ATXN3 binds SOD2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51437", "l": "acetyl-CoA + D-alanine => (2R)-2-amino-4-oxopentanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61312", "l": "germacra-1(10),4,11(13)-trien-12-ol + O2 + reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14522", "l": "(2E)-geraniol + NADP(+) => (2E)-geranial + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12215", "l": "9H-fluoren-9-ol + NADP(+) <=> 9H-fluoren-9-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170964", "l": "FRS2 binds to active TrkA receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55451", "l": "a 3',5'-unsubstituted flavanone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> a 3',5'-dihydroxyflavanone + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17608", "l": "ATP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine <=> ADP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379464", "l": "COMT transfers Met to DOPAC to form HVA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2032770", "l": "Translocation of YAP1 to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27711", "l": "ATP + guanosine => ADP + GMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008908", "l": "isochorismatase activity"}, {"i": "KEGG.REACTION:R03037"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-453342", "l": "PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "56.24351158283762", "identifiers": [{"i": "GO:0038023", "l": "signaling receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2752125", "l": "SPP1 (osteopontin) binds integrins alphaVbeta1, alphaVbeta3, alphaVbeta5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21802", "l": "all-trans-zeaxanthin + H2O + L-dehydroascorbate => all-trans-antheraxanthin + L-ascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57606", "l": "2 [Fe(III)-cytochrome b5] + a 1-[(15Z)-tetracos-15-enoyl]-2-acyl-phosphoglycerolipid + 2 H2O => 2 [Fe(II)-cytochrome b5] + a 1-tetracosanoyl-2-acyl-phosphoglycerolipid + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430190", "l": "p-SLP-76 binds NCK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202144", "l": "Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49882", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.29"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53213", "l": "17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] => 17beta,18-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047198", "l": "cysteine-S-conjugate N-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625901", "l": "CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51120", "l": "(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 AH2 = (8S,15S)-dihydroxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665748", "l": "FMNL2 binds RHOC:GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047471", "l": "maltose alpha-D-glucosyltransferase activity"}, {"i": "MetaCyc:5.4.99.16-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052675", "l": "3-methylbutanol:NADP oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863727", "l": "STON2 is neddylated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41497", "l": "1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551648", "l": "SUMOylation of TDG with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43643", "l": "dodecanoyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxotetradecanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791123", "l": "Expression of KDELR3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11819", "l": "aldehydo-D-glucose 6-phosphate <=> keto-D-fructose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.16"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23199", "l": "3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine <=> 3 AMP + 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211951", "l": "CYP1B1 4-hydroxylates EST17b (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.286", "l": "\"Chalcone 4'-O-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54301", "l": "n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate => n adenosine 3',5'-bisphosphate + chondroitin 4',6'-disulfate + n H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52044", "l": "mogrol + UDP-alpha-D-glucose = H(+) + mogroside IE + UDP"}, {"i": "EC:2.4.1.350", "l": "\"Mogroside IE synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25554", "l": "diphosphate + stemar-13-ene => 9alpha-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29707", "l": "1,6-anhydro-N-acetyl-beta-muramate(in) = 1,6-anhydro-N-acetyl-beta-muramate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45340", "l": "[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O = (9Z)-hexadecenoate + [Wnt protein]-L-serine + H(+)"}, {"i": "EC:3.1.1.98", "l": "\"[Wnt protein] O-palmitoleoyl-L-serine hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693751", "l": "FAAH2 hydrolyses AEA to AA and ETA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58710", "l": "rifampicin para-naphthoquinone carboxamide => rifampicin ortho-naphthoquinone carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17992", "l": "ATP + L-seryl-[protein] <=> ADP + H(+) + O-phospho-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56004", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)"}, {"i": "EC:3.2.1.209", "l": "\"Endoplasmic reticulum Man(9)GlcNAc(2) 1,2-alpha-mannosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17178", "l": "(R)-carnitine + octanoyl-CoA => CoA + O-octanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379996", "l": "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58021", "l": "6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) => eupatolide + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106271", "l": "D-arabinose 1-dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050371", "l": "tyrosine phenol-lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52866", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+) => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033801", "l": "vitexin 2''-O-rhamnoside 7-O-methyltransferase activity"}, {"i": "RHEA:11432", "l": "S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside = 7-O-methylvitexin 2''-O-beta-L-rhamnoside + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.153", "l": "\"Vitexin 2''-O-rhamnoside 7-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797962", "l": "DMGLY translocates from cytosol to mitochondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19905", "l": "NAD(+) + spermidine = dehydrospermidine + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1013020", "l": "Activation of GIRK/Kir3 Channels (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63023", "l": "(9Z,12Z)-octadecadienamide + H2O <=> (9Z,12Z)-octadecadienoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73757", "l": "Binding of RRN3 to RNA Polymerase I (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29845", "l": "ADP + phosphate + propanoyl-CoA => ATP + CoA + propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66471", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O <=> (17E)-cheilanthenediol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200406", "l": "CPT1A,B transfers PALM to CAR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54528", "l": "aldehydo-D-ribose 5-phosphate = D-ribose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23453", "l": "2'-deoxyadenosine + ATP => ADP + dAMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14931", "l": "androst-4-ene-3,17-dione + H(+) + NADH => NAD(+) + testosterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174255", "l": "Degradation multiubiquitinated Cyclin A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53652", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30546", "l": "(S)-carnitine + ATP + CoA <=> (S)-carnitinyl-CoA + ADP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.52", "l": "\"Calpain-1\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211968", "l": "CYP2W1 oxidises INDOL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032601", "l": "FYN-mediated phosphorylation of GRIN2B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33996", "l": "gamma-L-glutamyl-butirosin B => 5-oxo-L-proline + butirosin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112703", "l": "PTPN11 is phosphorylated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3299657", "l": "Defective TCII does not bind Cbl in the circulation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691131", "l": "CANDI binds CUL1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450533", "l": "PKCdelta phosphorylates HuR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202703", "l": "CD47 binds SIRP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52919", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52530", "l": "2-oxosuccinamate + L-glutamate => 2-oxoglutarate + L-asparagine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847977", "l": "FRK phosphorylates PTEN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11737", "l": "2-exo-hydroxy-1,8-cineole + NAD(+) => 6-oxocineole + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033440", "l": "ACG codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388981", "l": "The Kiss receptor GPR54 binds kisspeptin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171011", "l": "Binding and activation of MAP Kinase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-517705", "l": "p-S318,221-HuR binds mRNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49039", "l": "(-)-pluviatolide + S-adenosyl-L-methionine <=> (-)-bursehernin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56998", "l": "apulose => aldehydo-D-apiose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371527", "l": "HSF1 trimer translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19694", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+) => 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45817", "l": "(S)-lactate + A => AH2 + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17299", "l": "CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA => 2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46657", "l": "androst-4-ene-3,17-dione + H(+) + NADPH => 5beta-androstane-3,17-dione + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928619", "l": "PAK1 binds RAC1:GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23038", "l": "2 5'-dehydroinosine + 2 H2O => 2 inosine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20850", "l": "acetyl phosphate + CO2 + H2O2 => H(+) + O2 + phosphate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38186", "l": "19-hydroxytestosterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-oxotestosterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61839", "l": "ergosterol + UDP-alpha-D-glucose <=> ergosteryl 3-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41298", "l": "H2O + N-(hexanoyl)sphing-4-enine <=> hexanoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162836", "l": "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60722", "l": "(E)-hept-2-enoate + 2 H(+) + NADPH => (E)-hept-2-enal + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9641111", "l": "Parkin transfers Ub to misfolded proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10558", "l": "H(+) + N(2)-(2-carboxyethyl)-L-arginine + phosphate => D-glyceraldehyde 3-phosphate + L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013145", "l": "RAC1 binds effectors at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51029", "l": "2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 => 7-chloroindole-3-pyruvate imine dimer + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57642", "l": "(3-{(1R,2S,6S,8R)-2,8-dimethyl-3-[(E)-prop-1-enyl]-4,5-didehydrodecalin-2-yl}-3-oxopropanoyl)-[equisetin nonaketide synthase] + 8 CO2 + 8 CoA + 6 H2O + 8 NADP(+) + 2 S-adenosyl-L-homocysteine => 14 H(+) + holo-[equisetin nonaketide synthase] + 8 malonyl-CoA + 8 NADPH + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3781941", "l": "WNTs are secreted in exosomes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48800", "l": "a neolactoside nLc4Cer + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853911", "l": "VENTX stimulates TP53 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419166", "l": "GEFs activate RhoA,B,C (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018798", "l": "RHOV binds GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944218", "l": "Association of procollagen type VIII (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13969", "l": "(RNA)-3'-(3'-phosphooxy-ribonucleotide) + GTP = (RNA)-3'-(2',3'-cyclophosphooxy)-ribonucleotide + diphosphate + GMP"}, {"i": "EC:6.5.1.5", "l": "\"RNA 3'-terminal-phosphate cyclase (GTP)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045352", "l": "interleukin-1 type I receptor antagonist activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691204", "l": "TLR8 dimer binds TLR7, TLR8 ligands (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111915", "l": "CAMK4 autophosphorylates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805785", "l": "AKT phosphorylates PHF20 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32812", "l": "benzoate(in) => benzoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9035484", "l": "CysS248-MPST:TXN2 dissociates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54969", "l": "hexadecanoyl phosphate + sn-glycerol 3-phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2467775", "l": "Autocleavage of ESPL1 (Separase) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683964", "l": "ATM phosphorylates EYA1-4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11304", "l": "(S)-ureidoglycolate = glyoxylate + urea"}, {"i": "EC:4.3.2.3", "l": "\"Ureidoglycolate lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15414", "l": "(2R,3R)-tartrate => H2O + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952749", "l": "STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362386", "l": "Glycosylation of Hh (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64910", "l": "CMP + 2 H(+) + 2 phosphate => CTP + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682388", "l": "Autophagosome maturation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043839", "l": "lipid A phosphate methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30335", "l": "CTP + H(+) + H2O = NH4(+) + UTP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045353", "l": "interleukin-1 type II receptor antagonist activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632039", "l": "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374677", "l": "L1 binds ERM family members (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47491", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH <=> isodeoxycholate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32469", "l": "glycine betaine + 2 H(+) + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + sarcosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730903", "l": "Oligomerization of TRAF6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32085", "l": "CMP-pseudaminate + diphosphate => CTP + pseudaminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32461", "l": "H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + uroporphyrinogen III"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51715", "l": "keto-D-tagatose 6-phosphate <=> keto-D-fructose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165680", "l": "Formation of active mTORC1 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400204", "l": "PPARA binds RXRA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61153", "l": "(E)-caffeoyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] => CoA + myricetin 3-O-[(6-O-(E)-caffeoyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15244", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-yl acetate <=> 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421482", "l": "hydroxymethylbilane => uroporphyrinogen III + H2O (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61220", "l": "1,2-dihexadecanoyl-sn-glycero-3-CDP + 1D-myo-inositol 3-phosphate = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3965441", "l": "FZD recruits trimeric G-proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451516", "l": "activated MEK2 phosphorylates ERK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15831", "l": "a 16beta-hydroxysteroid => a 16alpha-hydroxysteroid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448629", "l": "IL33 binds IL1RL1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22243", "l": "H2O + methylenediurea <=> N-(carboxyaminomethyl)urea + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621270", "l": "FOXO1,FOXO3 bind PINK1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65523", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> all-trans-3-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38710", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33872", "l": "(S)-2-ureidoglycine + H2O => glyoxylate + NH4(+) + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25890", "l": "H(+) + 2 H2O + phosphate + quinolinate => dihydroxyacetone phosphate + iminosuccinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429101", "l": "HMIT co-transports myo-inositol with a proton (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690701", "l": "SHP1 binds p-CD22 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29278", "l": "L-isoleucine(in) + Na(+)(in) <=> L-isoleucine(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781899", "l": "USP13 binds SIAH2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375133", "l": "Basigin binds Mannose-carrying cell recognition molecules (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428534", "l": "Recruitment of Profilin by Ena/VASP proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34139", "l": "Delta(9)-tetrahydrocannabinolate + H(+) = CO2 + Delta(9)-tetrahydrocannabinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36145", "l": "hexadecanoyl-CoA + NADP(+) => (2E)-hexadecenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36004", "l": "(S)-4-hydroxy-2-oxohexanoate => propanal + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606839", "l": "Steryl sulfatase hydrolyses sulfate from steroid sulfates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374667", "l": "DCC interaction with SIAH2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35519", "l": "(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl) ethanolamine + H2O = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58785", "l": "2-oxoglutarate + a 5'-methyltriphosphate-guanosine-ribonucleotide-snRNA + O2 => a 5'-triphospho-guanosine-ribonucleotide-snRNA + CO2 + formaldehyde + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36534", "l": "(13Z)-docosenoyl-CoA + H(+) + malonyl-CoA <=> (15Z)-3-oxotetracosenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853308", "l": "Activated FGFR3 fusions:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36235", "l": "1-O-alkyl-sn-glycero-3-phosphate + an acyl-CoA = 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417122", "l": "Elongation and translocation of the telomeric chromosome end (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691150", "l": "TFR2 dimer binds 2xholoTF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35520", "l": "(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl) ethanolamine + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18366", "l": "(R)-malate + NAD(+) => CO2 + NADH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48235", "l": "acetyl-CoA + L-glutamate 5-semialdehyde <=> CoA + H(+) + N-acetyl-L-glutamate 5-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-376419", "l": "Formation of NR-MED1 Coactivator Complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001537", "l": "N-acetylgalactosamine 4-O-sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983707", "l": "SYK autophosphorylates at the activated BCR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31479", "l": "soyasapogenol A + UDP-alpha-D-glucuronate = H(+) + soyasapogenol A 3-O-beta-D-glucuronate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31710", "l": "2 H(+) + O2 + pentalen-13-ol + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29111", "l": "H(+) + NADPH + ubiquinone-8 = NADP(+) + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866277", "l": "AP-2 directly binds some endocytic cargo (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2179413", "l": "Activated PKC-alpha  activate MMP3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59854", "l": "(R)-tetrahydrodehydrodiconiferyl alcohol + NADP(+) => (2S,3R)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38126", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450494", "l": "HuR binds mRNAs in the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177922", "l": "EGFR dimerization (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38564", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + H2O => 1-O-hexadecyl-sn-glycerol + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39797", "l": "7beta-hydroxycholesterol(out) + ADP + H(+) + phosphate => 7beta-hydroxycholesterol(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622604", "l": "BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654511", "l": "FGFRL1 dimer binds FGFs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-435375", "l": "ZnT2 facilitates zinc vesicular sequestration (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43692", "l": "ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] = AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase]"}, {"i": "EC:2.7.11.32", "l": "\"[Pyruvate, phosphate dikinase] kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.8", "l": "\"Protein-secreting ATPase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871376", "l": "p-Y281,292-RUFY1 binds PI3P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18319", "l": "a D-alpha-amino acid => an L-alpha-amino acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5663050", "l": "DHI and DHICA polymerise forming eumelanin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50633", "l": "a 2-(omega-methylsulfanyl)alkylmalate => a 2-(omega-methylsulfanyl)alkylmaleate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44676", "l": "a triacyl-sn-glycerol + all-trans-retinol = a diacylglycerol + an all-trans-retinyl ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874685", "l": "CBL binds MET (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4090281", "l": "PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29643", "l": "alpha-maltoheptaose + H2O = alpha-D-glucose + alpha-maltohexaose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43661", "l": "ATP + hydrogencarbonate + propanoyl-CoA => ADP + H(+) + methylmalonyl-CoA + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429694", "l": "CERT:PPM1L:VAPA/B [ER] => CERT [cytosol] + PPM1L:VAPA/B [ER] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237129", "l": "Acireductone is created (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981931", "l": "RAC1 and CDC42 activate PAK2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53397", "l": "dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] => 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25056", "l": "(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+) => (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33970", "l": "2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O <=> 3-maleylpyruvate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295622", "l": "SPRY2 binds CBL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30723", "l": "A + 2 ADP + H(+) + NH4(+) + 2 phosphate = AH2 + 2 ATP + H2O + hydroxylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209828", "l": "Tryptophan is hydroxylated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28110", "l": "chloride + S-adenosyl-L-methionine = 5'-chloro-5'-deoxyadenosine + L-methionine"}, {"i": "EC:2.5.1.94", "l": "\"Adenosyl-chloride synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36724", "l": "2-phenylethylamine + A + H2O => 2-phenylacetaldehyde + AH2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20509", "l": "ATP + viomycin = ADP + H(+) + O-phosphoviomycin"}, {"i": "EC:2.7.1.103", "l": "\"Viomycin kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51592", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + toluene = benzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0003714", "l": "transcription corepressor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449117", "l": "TXLNA (IL14) binds syntaxin1A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23644", "l": "lithocholate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hyodeoxycholate + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605736", "l": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44112", "l": "hexadecanoyl-CoA + nonan-1-ol = CoA + nonyl hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46482", "l": "4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 4alpha-formyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57721", "l": "ATP + 4 H(+)(in) + H2O => ADP + 5 H(+)(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48404", "l": "apo-[EntB isochorismatase/aryl-carrier protein] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[EntB isochorismatase/aryl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444100", "l": "PROT mediates L-proline uptake (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52707", "l": "H2O + UMP <=> D-ribose 5-phosphate + uracil"}]}
{"type": "biolink:MolecularActivity", "ic": "68.973118714897424", "identifiers": [{"i": "GO:0005319", "l": "lipid transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004847", "l": "urea carboxylase activity"}, {"i": "RHEA:20896", "l": "ATP + hydrogencarbonate + urea = ADP + H(+) + phosphate + urea-1-carboxylate"}, {"i": "EC:6.3.4.6", "l": "\"Urea carboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64614", "l": "AMP + diphosphate + L-glutamyl-tRNA(Gln) => ATP + L-glutamate + tRNA(Gln)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102123", "l": "gibberellin A4 16alpha,17 epoxidase activity"}, {"i": "MetaCyc:RXN-11385"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202111", "l": "AKT1 phosphorylates eNOS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9032798", "l": "DOCK3 activates RAC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31197", "l": "3-oxooctanoyl-CoA + H(+) + NADH => (3S)-hydroxyoctanoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15056", "l": "(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862733", "l": "CCR2, CCR3 bind CCL13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11123", "l": "cyanate + 3 H(+) + hydrogencarbonate <=> 2 CO2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34734", "l": "15-methylhexadecasphing-4-enine + a fatty acyl-CoA <=> CoA + H(+) + N-acyl-15-methylhexadecasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692779", "l": "p-S182 MAPKAPK5 phosphorylates FOXO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62390", "l": "[(1->2)-beta-D-glucosyl](n-2) + sophorose => [(1->2)-beta-D-glucosyl](n) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44074", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+) => 1-O-alkyl-2-acyl-sn-glycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49101", "l": "H2O + Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine => 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46610", "l": "ADP + H(+) + O-phospho-L-threonyl-[protein] => ATP + L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20124", "l": "ATP + L-glutamine + tRNA(Gln) <=> AMP + diphosphate + L-glutaminyl-tRNA(Gln)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35069", "l": "(S)-carnitine(in) => (S)-carnitine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392834", "l": "Activation of EPACs by cAMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062050", "l": "GPI-mannose ethanolamine phosphate phosphodiesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627078", "l": "XIAP binds CASP9 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570528", "l": "SUMOylation of XPC with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29998", "l": "ATP + H2O + putrescine(out) <=> ADP + H(+) + phosphate + putrescine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449077", "l": "Interleukin-16 is secreted (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062147", "l": "L-lysine 4-chlorinase activity"}, {"i": "RHEA:59884", "l": "2-oxoglutarate + chloride + H(+) + L-lysine + O2 = 4-chloro-L-lysine + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42152", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acyl-(4R)-4-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166538", "l": "The bound receptor dimerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60455", "l": "2-hydroxyethane-1-sulfonate <=> acetaldehyde + H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0004652", "l": "polynucleotide adenylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380227", "l": "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045027", "l": "DNA end binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48319", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b <=> a ganglioside GD1alpha + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2288097", "l": "Condensin II complex binds H4K20me1-containing nucleosomes (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61208", "l": "8-nitro-cGMP + L-cysteinyl-[protein] = H(+) + nitrite + S-(guanosine 3',5'-cyclic phosphate)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664261", "l": "Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28477", "l": "D-glucarate(in) <=> D-glucarate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19262", "l": "ATP + H2O + heme b(in) => ADP + H(+) + heme b(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56778", "l": "(+)-piperitol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (+)-pinoresinol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156699", "l": "Inactivation of Wee1 kinase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55714", "l": "(9Z)-octadecenoate + (S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+) => (S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23316", "l": "2'-deoxyuridine + 2-oxoglutarate + O2 = 2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil"}, {"i": "EC:1.14.11.10", "l": "\"Pyrimidine-deoxynucleoside 1'-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41471", "l": "ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oryzalexin E + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169683", "l": "IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28904", "l": "D-alanine(in) + H(+)(in) => D-alanine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865275", "l": "PDGF-BB clevage by Furin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45290", "l": "2-glyceryl-prostaglandin G2 => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016996", "l": "endo-alpha-(2,8)-sialidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196929", "l": "FLAD1 phosphorylates FMN (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691154", "l": "HFE binds TFRC dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10299", "l": "D-glyceraldehyde 3-phosphate + NADP(+) + phosphate <=> (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60370", "l": "urate(in) => urate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40442", "l": "6-sulfo-D-quinovose <=> 6-deoxy-6-sulfo-D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165680", "l": "Formation of active mTORC1 complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21534", "l": "ADP + H(+) + phosphate + trypanothione => ATP + glutathione + glutathionylspermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944218", "l": "Association of procollagen type VIII (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004550", "l": "nucleoside diphosphate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.4"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043774", "l": "coenzyme F420-2 alpha-glutamyl ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60453", "l": "2-hydroxyethane-1-sulfonate => acetaldehyde + H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32601", "l": "3-isopropenyl-6-oxoheptanoate + H(+) => 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44517", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O => (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985343", "l": "RUNX2 binds SOX9 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13471", "l": "5-methylbarbiturate + AH2 + H(+) => A + H2O + thymine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623427", "l": "IGFBP1 gene expression is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173739", "l": "Spontaneous hydrolysis of C3 thioester (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801762", "l": "REG3A oligomerize to form a pore complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40693", "l": "1-O-pentadecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + pentadecan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-549304", "l": "OCT3 mediates renal clearance of organic cations (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42999", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (R)-cembrene A + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.48", "l": "\"Uridine/cytidine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445084", "l": "Phosphorylation of L1 by SRC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047346", "l": "aldose-1-phosphate adenylyltransferase activity"}, {"i": "MetaCyc:2.7.7.36-RXN"}, {"i": "EC:2.7.7.36", "l": "\"Aldose-1-phosphate adenylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72672", "l": "The 60S subunit joins the translation initiation complex  (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983156", "l": "Polyubiquitination of substrate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62549", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D-galactose => beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693598", "l": "ATM phosphorylates NBN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27488", "l": "allantoate + 2 H(+) + H2O <=> (S)-2-ureidoglycine + CO2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48731", "l": "3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+) <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45297", "l": "a sphingosylphosphocholine + H2O => a sphingoid base + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20963", "l": "1D-myo-inositol hexakisphosphate + H2O <=> 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033406", "l": "UCC codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44340", "l": "(S)-2,3-diaminopropanoate + ATP + fumarate = AMP + diphosphate + N(3)-fumaroyl-(S)-2,3-diaminopropanoate"}, {"i": "EC:6.3.2.46", "l": "\"Fumarate--(S)-2,3-diaminopropanoate ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950128", "l": "Interleukin-12 dissociates from Interleukin-12 receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034568", "l": "isoproturon dimethylaminedehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48251", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0) <=> CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804099", "l": "HMGB1 binds LTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9688456", "l": "MLKL binds FLOT1, FLOT2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507869", "l": "Aquaporins passively transport glycerol into cells (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41145", "l": "1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+) => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30312", "l": "7-methylxanthine + H(+) + NADH + O2 => formaldehyde + H2O + NAD(+) + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38339", "l": "(20S)-ginsenoside Rb1 + H2O = (20S)-ginsenoside Rd + D-glucose"}, {"i": "EC:3.2.1.195", "l": "\"20-O-multi-glycoside ginsenosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649686", "l": "NEIL2 recognizes and binds 5-OHU-dsDNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008687", "l": "3,4-dihydroxyphenylacetate 2,3-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30743", "l": "beta-nicotinamide D-riboside + H2O = D-ribose + H(+) + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12498", "l": "6 H(+) + H2O2 + 2 iron(III) oxide-hydroxide => 2 Fe(2+) + 4 H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32087", "l": "[4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphoenolpyruvate = [4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-(S)-4,6-CH3(COO(-))C-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphate"}, {"i": "EC:2.5.1.98", "l": "\"Rhizobium leguminosarum exopolysaccharide glucosyl ketal-pyruvate-transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13178", "l": "6-phospho-5-dehydro-2-deoxy-D-gluconate => 3-oxopropanoate + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47912", "l": "6-deoxy-6-sulfo-D-gluconate = 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O"}, {"i": "EC:4.2.1.162", "l": "\"6-deoxy-6-sulfo-D-gluconate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4341048", "l": "SUMOylation of RXRA with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56084", "l": "[Rab1 protein]-O-phosphocholine-L-serine + H2O = [Rab1 protein]-L-serine + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58015", "l": "cyclic tetraadenylate <=> 2 5'-hydroxy-diadenylate 2',3'-cylic phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13116", "l": "2-acetamidofluorene + H2O + NADP(+) <=> H(+) + N-hydroxy-2-acetamidofluorene + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482770", "l": "Release of platelet secretory granule components (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57180", "l": "L-lysyl-[protein] + methylglyoxal = N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655313", "l": "Activated FGFR4 mutants bind PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63752", "l": "kermesate + UDP-alpha-D-glucose = carminate + 2 H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202328", "l": "Translocation of PKC theta to plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043912", "l": "D-lysine oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73577", "l": "CAD hexamer transforms L-Gln to CAP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140481", "l": "ABC-type iron-sulfur cluster transporter activity"}, {"i": "TCDB:3.A.1.210.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12352", "l": "L-gulono-1,4-lactone + O2 = H2O2 + L-xylo-hex-3-ulonolactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371582", "l": "HSBP1 binds HSF1 trimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052621", "l": "diguanylate cyclase activity"}, {"i": "RHEA:24898", "l": "2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate"}, {"i": "EC:2.7.7.65", "l": "\"Diguanylate cyclase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43277", "l": "ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GalNAc-GD1a + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40807", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65362", "l": "a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16212", "l": "Co-precorrin-8X <=> cob(II)yrinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66204", "l": "heptanoyl-CoA + O2 = (2E)-heptenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39787", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050606", "l": "4-carboxy-2-hydroxymuconate semialdehyde hemiacetal dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004496", "l": "mevalonate kinase activity"}, {"i": "RHEA:17065", "l": "(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)"}, {"i": "EC:2.7.1.36", "l": "\"Mevalonate kinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106245", "l": "L-serine-phosphatidylethanolamine phosphatidyltransferase activity"}, {"i": "RHEA:27606", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine"}, {"i": "EC:2.7.8.29", "l": "\"L-serine-phosphatidylethanolamine phosphatidyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3249378", "l": "STING recruits TBK1 and STAT6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15039", "l": "H(+) + N-methylputrescine + S-adenosyl-L-homocysteine => putrescine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14346", "l": "H(+) + L-tyrosine => CO2 + tyramine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44526", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-glycerol + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0002094", "l": "polyprenyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41937", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose => a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674019", "l": "BRAP binds KSR1:MARK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46216", "l": "H(+) + NADPH + progesterone = 3beta-hydroxypregn-4-ene-20-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17147", "l": "2'-hydroxydaidzein + 2 H(+) + NADPH => 2'-hydroxy-2,3-dihydrodaidzein + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051430", "l": "corticotropin-releasing hormone receptor 1 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41288", "l": "H2O + N-tetradecanoylsphing-4-enine => sphing-4-enine + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.54"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63710", "l": "2 [Fe(III)-cytochrome b5] + a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl derivative + 2 H2O => 2 [Fe(II)-cytochrome b5] + a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl derivative + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429860", "l": "DCP1-DCP2 complex decaps mRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030560", "l": "tRNA pseudouridylation guide activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805507", "l": "APAF1 binds AVEN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30602", "l": "15-cis-phytoene + 3 A <=> 3 AH2 + all-trans-neurosporene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56316", "l": "3-amino-4-hydroxybenzoate + acetyl-CoA = 3-acetylamino-4-hydroxybenzoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63739", "l": "2-phenylacetaldehyde + H(+) + NADPH <=> 2-phenylethanol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106307", "l": "protein threonine phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804100", "l": "HMGB1 binds LPS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9690461", "l": "FKBP1A binds tacrolimus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623643", "l": "RDH13 reduces atRAL to atROL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61427", "l": "cis-cis-nepetalactol + NAD(+) <=> cis-cis-nepetalactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39224", "l": "(3R)-hydroxyoctacosanoyl-CoA => (2E)-octacosenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26378", "l": "GTP => cyclic pyranopterin phosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16775", "l": "ganglioside GM1 (d18:1(4E)) + H(+) + UDP => ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5665767", "l": "Activated FMNL3 binds G-actin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51329", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => 10-hydroperoxy-(8Z,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420128", "l": "SRC-1 phosphorylates SHB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29249", "l": "3 H(+)(in) + 2 Na(+)(out) => 3 H(+)(out) + 2 Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25666", "l": "(2E)-geranyl diphosphate = beta-pinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40526", "l": "a quinone + succinate <=> a quinol + fumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004025", "l": "alcohol dehydrogenase activity, iron-dependent"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54328", "l": "2 H(+) + hexadecanoyl-[ACP] + 2 NADPH = hexadecan-1-ol + holo-[ACP] + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028821", "l": "Dimerization of Phospho IRF3 or phospho IRF7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18976", "l": "2-oxoglutarate + deacetoxyvindoline + O2 <=> 4-O-deacetylvindoline + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.52"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793958", "l": "Expression of STAT6-upregulated plasma membrane proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928617", "l": "EPHB2 binds KALRN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33804", "l": "H2O + L-histidinal + NAD(+) => 2 H(+) + L-histidine + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33439", "l": "glyoxal + H2O + O2 = glyoxylate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52533", "l": "adenosine + GTP => AMP + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37544", "l": "2-amino-5-chlorophenol + O2 => 2-amino-5-chloromuconate 6-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170991", "l": "SRC-1 autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156678", "l": "Activation of Cdc25C (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64776", "l": "3-sulfanylpentan-1-ol-L-cysteine = 2-aminoprop-2-enoate + 3-sulfanyl-1-pentanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13695", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+) => (6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49229", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + bacteriochlorophyllide a + H(+) => diphosphate + geranylgeranyl-bacteriochlorophyllide a"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58548", "l": "2 L-ascorbate + N-(9Z,12Z,15Z)-octadecatrienoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19899", "l": "4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide => H(+) + 2 L-arginine + 3 NADPH + 4 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41537", "l": "2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine => 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58419", "l": "(E)-4-hydroxynon-2-en-1-ol + NADP(+) <=> (E)-4-hydroxynon-2-enal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374919", "l": "Noradrenaline clearance from the synaptic cleft (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419428", "l": "S1PR2-5 bind S1P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36871", "l": "(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36358", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63504", "l": "daunorubicin + H(+) + NADPH = 13-dihydrodaunorubicin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052658", "l": "inositol-1,4,5-trisphosphate 5-phosphatase activity"}, {"i": "KEGG.REACTION:R03394"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0042314", "l": "bacteriochlorophyll binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210430", "l": "Release of L-Glutamate at the synapse (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-196773", "l": "COASY phosphorylates DP-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9727349", "l": "XDH dehydrogenates xanthine to form urate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57954", "l": "catechol + H2O + NAD(+) => H(+) + NADH + O2 + phenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37387", "l": "(9Z)-octadecenoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264615", "l": "Loading of acetylcholine in synaptic vesicles (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983285", "l": "RAD51B binds RAD51C (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5684140", "l": "ATM phosphorylates RBBP8 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26488", "l": "L-cysteate + phosphate => H(+) + O-phospho-L-serine + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696465", "l": "USP45 deubiquitinates ERCC1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008020", "l": "G protein-coupled photoreceptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043876", "l": "D-threonine aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211164", "l": "AKT phosphorylates FOXO1A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13203", "l": "guanidinoacetate + L-ornithine => glycine + L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392513", "l": "Rap1 signal termination by Rap1GAPs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12351", "l": "(S)-muconolactone <=> (4,5-dihydro-5-oxofuran-2-yl)-acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798748", "l": "Exocytosis of secretory granule lumen proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11192", "l": "an (S)-2-haloacid + H2O = a (2R)-2-hydroxycarboxylate + a halide anion + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444047", "l": "Receptor FFAR3 binds carboxylates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172172", "l": "Ubiquitination of DLL/JAG ligands upon binding to NOTCH2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13718", "l": "2-C-methyl-D-erythritol 4-phosphate + NADP(+) => 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708457", "l": "HM13 cleaves HMOX1 dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56027", "l": "H2O + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4551648", "l": "SUMOylation of TDG with SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10350", "l": "ADP + H(+) + L-glutamate + phosphate => 5-oxo-L-proline + ATP + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "75.076548671259488", "identifiers": [{"i": "GO:0008175", "l": "tRNA methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932334", "l": "KEAP1:CUL3:RBX1:NFE2L2 dissociates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47486", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => deoxycholate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9612219", "l": "ERBB4s80 binds to SRC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085347", "l": "PIAS1 SUMOylates SAFB with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37464", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877620", "l": "ECE2 cleaves EDN1(53-90) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993790", "l": "Transfer of SUMO2 from E1 to UBE2I (UBC9) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51250", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174446", "l": "Removal of remaining Flap from the C-strand (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653893", "l": "ATF4, CEBPB, and ATF3 bind the CHAC1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5357483", "l": "RAC1 binds PAK1-3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062083", "l": "HLA-G specific inhibitory MHC class Ib receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11206", "l": "AMP + diphosphate + H(+) + holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] => apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66196", "l": "acetyl-CoA + tryptamine = CoA + H(+) + N-acetyltryptamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32351", "l": "3 S-adenosyl-L-methionine + tricetin = 3',4',5'-O-trimethyltricetin + 3 H(+) + 3 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.169", "l": "\"Tricetin 3',4',5'-O-trimethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52619", "l": "3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + ATP <=> 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-threonyl-[protein] + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60403", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O <=> Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857565", "l": "Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47851", "l": "2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) <=> CO2 + diphosphate + thiamine phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56300", "l": "[thioredoxin]-dithiol + S-sulfanyl-L-cysteinyl-[protein] = [thioredoxin]-disulfide + H(+) + hydrogen sulfide + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5651773", "l": "LIG1 binds POLB at long-patch BER site (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35223", "l": "2-oxo-dADP + H2O = 2-hydroxy-dAMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24197", "l": "(2R,4S)-2,4-diaminopentanoate + H2O + NAD(+) => (2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43627", "l": "2-aminomalonate semialdehyde + H(+) <=> aminoacetaldehyde + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20282", "l": "3'-phosphoadenylyl sulfate + desulfoglucotropeolin => adenosine 3',5'-bisphosphate + glucotropeolin + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13792", "l": "[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.5", "l": "\"Beta-aspartyl-peptidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047363", "l": "triglucosylalkylacylglycerol sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797974", "l": "LRRTMs bind NRXNs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13434", "l": "2'-deoxycytidine + H(+) + H2O => 2'-deoxyuridine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37716", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43883", "l": "3beta-hydroxy-5-cholestenoate + ATP + CoA <=> 3beta-hydroxy-5-cholestenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012542", "l": "IL37 binds 2x(CASP1(120-197):CASP1(317-404)) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28153", "l": "acetyl-CoA + spermidine <=> CoA + H(+) + N(1)-acetylspermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158795", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392513", "l": "Rap1 signal termination by Rap1GAPs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40886", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + FAD + H(+) <=> (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65401", "l": "butan-1-ol + butanoyl-CoA => butyl butanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028583", "l": "Phosphorylation of YAP by LATS2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9038052", "l": "GREB1 binds ESR1:ESTG and co-activators (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210294", "l": "Interaction of PECAM-1 and SHP-2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202110", "l": "eNOS:Caveolin-1 complex binds to CaM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21322", "l": "AH2 + keto-L-sorbose => A + D-sorbitol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74742", "l": "Phosphorylation of SHC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11242", "l": "ADP + thiamine triphosphate => ATP + thiamine diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195304", "l": "Association of beta-catenin with the destruction complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944047", "l": "JUN binds the PTEN gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0106075", "l": "peptide N-succinyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19360", "l": "H(+) + L-proline betaine + NADPH + O2 <=> formaldehyde + H2O + N-methyl-L-proline + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55035", "l": "an N-methylornithine lipid + S-adenosyl-L-methionine <=> an N,N-dimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086040", "l": "sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034958", "l": "aminohydroquinone monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55065", "l": "4-methylpentanoyl-CoA + H2O => 4-methylpentanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42259", "l": "H(+) + hexanoyl-CoA + malonyl-[ACP] <=> 3-oxooctanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8857686", "l": "FITM1, FITM2 bind TAGs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25902", "l": "beta-D-fructose 6-phosphate => D-arabino-hex-3-ulose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41631", "l": "geranylgeranyl diphosphate + H2O <=> cyclooctat-9-en-7-ol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24535", "l": "2-methylbutanoyl-CoA + NAD(+) <=> 2-methylbut-2-enoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047749", "l": "cholestanetriol 26-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047101", "l": "2-oxoisovalerate dehydrogenase (acylating) activity"}, {"i": "RHEA:13997", "l": "3-methyl-2-oxobutanoate + CoA + NAD(+) = 2-methylpropanoyl-CoA + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52581", "l": "ATP + H2O + Pb(2+)(in) => ADP + H(+) + Pb(2+)(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50484", "l": "acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.45", "l": "\"Helper-component proteinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38774", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55811", "l": "2 [Fe(II)-cytochrome b5] + a dihydroceramide + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a phytoceramide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15955", "l": "ADP + 2 H(+) + N(4)-phosphoagmatine => agmatine + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8847537", "l": "RAB43:GTP binds USP8NL (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3204303", "l": "MRE11 binds cytosolic DNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437118", "l": "GPVI stimulates PI3K beta, gamma (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2176452", "l": "Degradation of ubiquitinated SMAD2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19864", "l": "a 16alpha-hydroxysteroid + NAD(+) <=> a 16-oxosteroid + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23095", "l": "H(+) + H2O + hydroxyatrazine <=> ethylamine + N-isopropylammelide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41479", "l": "5alpha-cholesta-8,24-dien-3beta-ol + an acyl-CoA <=> CoA + zymosterol ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868236", "l": "BAR domain proteins recruit dynamin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1028821", "l": "Dimerization of Phospho IRF3 or phospho IRF7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2213201", "l": "Formation of collagen fibres (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036218", "l": "dTTP diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53393", "l": "2-phenylacetate + O2 + reduced [NADPH--hemoprotein reductase] => (2-hydroxyphenyl)acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.-", "l": "\"Sulfuric ester hydrolases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32372", "l": "all-trans-violaxanthin + 2 L-ascorbate => all-trans-zeaxanthin + 2 H2O + 2 L-dehydroascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31631", "l": "2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H2O + phosphoenolpyruvate = phosphate + pseudaminate"}, {"i": "EC:2.5.1.97", "l": "\"Pseudaminic acid synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36460", "l": "glycyl-L-proline + H2O => glycine + L-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190245", "l": "FGFR1b binds to FGF (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32964", "l": "2-oxoglutaramate + H2O => 2-oxoglutarate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-349426", "l": "Phosphorylation of MDM4 by CHEK2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372449", "l": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614544", "l": "Sulfite is oxidized to sulfate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3076881", "l": "BCTN translocates to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21152", "l": "trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline"}, {"i": "EC:5.1.1.8", "l": "\"4-hydroxyproline epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000253", "l": "3-keto sterol reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63265", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + O2 => 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6781840", "l": "ERCC6 binds stalled RNA Pol II (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111962", "l": "PDE4A,C,D hydrolyse cAMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53529", "l": "1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-(9Z-octadecenoyl)-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55826", "l": "a bacteriochlorophyllide f + H2O => a 7(1),7(1)-dihydroxybacteriochlorophyllide d"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39195", "l": "3-oxotetracosanoyl-CoA + H(+) + NADPH = (3R)-hydroxytetracosanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190520", "l": "Association of Golgi  transport vesicles with microtubules (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63937", "l": "3 a ubiquinone + protoporphyrinogen IX => 3 a ubiquinol + protoporphyrin IX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877490", "l": "FOXP3 in complex with RUNX1 binds to the TNFRSF18 (GITR) gene intron 1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59913", "l": "(E)-4-hydroxynon-2-enal + H2O + NADP(+) => (E)-4-hydroxynon-2-enoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112604", "l": "Phosphorylated STATs are released (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66693", "l": "dTDP-beta-L-rhamnose + L-arginyl-[protein] => dTDP + H(+) + N(omega)-(alpha-L-rhamnosyl)-L-arginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042329", "l": "structural constituent of collagen and cuticulin-based cuticle"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.10", "l": "\"Homocysteine S-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24883", "l": "(S)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+) => H(+) + L-glutamate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40964", "l": "4 2-aminophenol + 3 O2 => 2 2-aminophenoxazin-3-one + 6 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37093", "l": "3-oxo-(10Z,13Z,16Z)-docosatrienoyl-CoA + CO2 + CoA => (8Z,11Z,14Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.12", "l": "\"Ribonuclease E\""}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0004551", "l": "nucleotide diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6794346", "l": "NRXNs bind NLGNs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0050780", "l": "dopamine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27389", "l": "(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O = pyruvate + salicylaldehyde"}, {"i": "EC:4.1.2.45", "l": "\"Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032003", "l": "interleukin-28 receptor binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015636", "l": "short-chain fatty acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446322", "l": "PARVA associates with Paxillin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53445", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 11beta,17beta-dihydroxyandrost-4-ene-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20351", "l": "2-hydroxytoluene + H2O + NAD(+) => H(+) + NADH + O2 + toluene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39072", "l": "dodecanedioyl-CoA + O2 => (2E)-dodecenedioyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855131", "l": "VLDLR:PCSK9 binds Clathrin-coated vesicles (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112385", "l": "Addition of nucleotides leads to transcript elongation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905201", "l": "gibberellin transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43031", "l": "L-cysteate <=> 2-aminoprop-2-enoate + H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11777", "l": "2 H(+) + O2 + octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin] => (9Z)-octadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211968", "l": "CYP2W1 oxidises INDOL (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12878", "l": "acetylacetone + O2 => acetate + H(+) + methylglyoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46193", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] => 3beta,7alpha-dihydroxyandrost-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13408", "l": "4-coumaroyl-CoA + agmatine <=> CoA + H(+) + N-(4-guanidinobutyl)-4-hydroxycinnamamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60692", "l": "(E)-non-2-enal + H2O + NADP(+) = (E)-non-2-enoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805205", "l": "GPR35 binds kynurenic acid (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58331", "l": "(Z)-non-6-en-1-ol + NADP(+) <=> (Z)-non-6-enal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64155", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP-N-acetyl-beta-neuraminate <=> alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102673", "l": "fatty aldehyde dehydrogenase activity"}, {"i": "MetaCyc:RXN-4142"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13062", "l": "O2 + S-sulfanylglutathione => glutathione S,S-dioxide + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-380930", "l": "Phosphorylated AMPK binds AMP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45339", "l": "(9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine <=> [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433711", "l": "Cis-homodimerization of nectins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6802973", "l": "PLK3 phosphorylates CDC25C (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16670", "l": "H2O + NAD(+) + xanthine => H(+) + NADH + urate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420233", "l": "VIP receptors bind VIP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48602", "l": "[protein-PII]-L-tyrosine + H(+) + UMP => [protein-PII]-uridylyl-L-tyrosine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58277", "l": "6 ATP => cyclic hexaadenylate + 6 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38772", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868230", "l": "SNX9 recruits components of the actin polymerizing machinery (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18982", "l": "(R)-pantolactone + NADP(+) => 2-dehydropantolactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199112", "l": "CRTAM binds to NECL2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33022", "l": "(3S)-3,6-diaminohexanoate + acetyl-CoA <=> (3S)-6-acetamido-3-aminohexanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-622415", "l": "RIP2 binds NEMO (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450975", "l": "isocitrate <=> citrate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49509", "l": "phosphinomethylmalate => 2-(phosphinatomethylidene)butanedioate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10138", "l": "2-hydroxy-3-oxopropanoate + CO2 => 2 glyoxylate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62212", "l": "3-hydroxybenzyl alcohol + O2 + reduced [NADPH--hemoprotein reductase] = gentisyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43545", "l": "ATP + L-glutamate + tyramine => ADP + gamma-L-glutamyltyramine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62224", "l": "H(+) + NADPH + neopatulin = (E)-ascladiol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944538", "l": "miR-22 microRNA binds PTEN mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917987", "l": "TFRC dimer binds 2xholoTF (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29339", "l": "(S)-malate(in) + 2 H(+)(in) = (S)-malate(out) + 2 H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9626928", "l": "CREBBP binds FOXO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202222", "l": "Phosphorylation of PKC theta (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200954", "l": "Nef Binds and activates the Src-family tyrosine kinase Lck (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10594", "l": "a 3'-hydroxy,5'-unsubstituted flavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 3',5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042896", "l": "chloramphenicol transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9626816", "l": "PIN1 binds p-S345-NCF1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54581", "l": "5'-dephospho-(RNA) + ATP => 5'-end-(RNA) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448660", "l": "IL31:IL31RA:JAK1 binds OSMR:JAK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052597", "l": "diamine oxidase activity"}, {"i": "MetaCyc:RXN-9599"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39691", "l": "(2E,11Z)-octadecadienoyl-CoA + H(+) + NADPH = (11Z)-octadecenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25713", "l": "2 H(+) + H2O + N-hydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase] => L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64885", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + UMP => (6S)-5,6,7,8-tetrahydrofolate + 5-methyl-UMP + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18819", "l": "acetate + malonyl-CoA => acetyl-CoA + malonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52532", "l": "adenosine + GTP = AMP + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19664", "l": "D-mannitol 1-phosphate + NAD(+) <=> beta-D-fructose 6-phosphate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.27"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913451", "l": "IL3RB is phosphorylated on Ser-585 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34472", "l": "NAD(+) + propanoyl-CoA => acryloyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76456", "l": "O-atom dealkylation of dextromethorphan (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213200", "l": "Release of endostatin-like peptides (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25317", "l": "L-2-acetamido-6-oxoheptanedioate + L-glutamate => 2-oxoglutarate + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4827388", "l": "CTNNB1 S45 mutants aren't phosphorylated by CK1alpha (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36126", "l": "gibberellin A20 + S-adenosyl-L-methionine <=> gibberellin A20 methyl ester + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58280", "l": "4 ATP = cyclic tetraadenylate + 4 diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030701", "l": "NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450723", "l": "RAC1:GTP and MSN activate HEP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004901", "l": "granulocyte macrophage colony-stimulating factor receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730767", "l": "Monofunctional chemotherapeutic alkylating drugs produce 7-methylguanine in dsDNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40351", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP = 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29894", "l": "ATP + H2O + L-histidine(out) <=> ADP + H(+) + L-histidine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65330", "l": "AH2 + chrodrimanin H => A + chrodrimanin F"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62828", "l": "GDP-beta-L-fucose + methyl-8-{[beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9710254", "l": "GSDME oligomerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64349", "l": "2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H(+) => deacetylpyripyropene E"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9010815", "l": "SLITs bind keratan sulfate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990663", "l": "dihydroorotate dehydrogenase (fumarate) activity"}, {"i": "RHEA:30059", "l": "(S)-dihydroorotate + fumarate = orotate + succinate"}, {"i": "EC:1.3.98.1", "l": "\"Dihydroorotate oxidase (fumarate)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57456", "l": "E-sinapate + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-trans-sinapate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606312", "l": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.-", "l": "\"Linked to the hydrolysis of a nucleoside triphosphate\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015504", "l": "cytosine:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001634", "l": "pituitary adenylate cyclase-activating polypeptide receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9628758", "l": "NEIL1 G83D does not cleave FapyG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73577", "l": "CAD hexamer transforms L-Gln to CAP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047755", "l": "isocitrate epimerase activity"}, {"i": "RHEA:10820", "l": "D-threo-isocitrate = D-erythro-isocitrate"}, {"i": "EC:5.1.2.6", "l": "\"Isocitrate epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710263", "l": "GZMB cleaves GSDME (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419841", "l": "Light stimulates opsin receptors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57101", "l": "S-methyl-5-thio-D-ribulose 1-phosphate => S-methyl-1-thio-D-xylulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42603", "l": "AH2 + prostaglandin G2 <=> A + H2O + prostaglandin H2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48371", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose <=> beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46550", "l": "2 [Fe(III)-cytochrome b5] + 2 H2O + N-acyl-(4E,8E,10E)-sphingatrienine => 2 [Fe(II)-cytochrome b5] + a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27834", "l": "a menaquinone + succinate = a menaquinol + fumarate"}, {"i": "RHEA:40523", "l": "a quinone + succinate = a quinol + fumarate"}, {"i": "EC:1.3.5.4", "l": "\"Fumarate reductase (quinol)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102836", "l": "1-18:1-2-16:1-monogalactosyldiacylglyceroldesaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54588", "l": "S-adenosyl-L-methionine + uridine in 25S rRNA = H(+) + N(3)-methyluridine in 25S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564143", "l": "Collagen type X degradation by MMP1,2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46355", "l": "(2E)-decenoyl-CoA + H2O <=> 3-hydroxydecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626817", "l": "PKC phosphorylates NCF1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917841", "l": "Acidification of Tf:TfR1 containing endosome (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-917696", "l": "Cargo Sequestration (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9604767", "l": "FLT3LG dimer:FLT3 dimer autophosphorylates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396399", "l": "Fibrillins bind BMPs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14431", "l": "a [oligopeptide](out) + ADP + H(+) + phosphate => a [oligopeptide](in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034878", "l": "2-hydroxyisonicotinate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42502", "l": "6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42119", "l": "5alpha-androstane-3alpha,17beta-diol + NADP(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139920", "l": "Translocation of tBID to mitochondria (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17861", "l": "21-hydroxyprogesterone = 20-hydroxy-3-oxopregn-4-en-21-al"}, {"i": "EC:5.3.1.21", "l": "\"Corticosteroid side-chain-isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35905", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA => 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388832", "l": "PI3K binds CD28 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9611852", "l": "ADRB3 bind ADR,NAd (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62377", "l": "2,4-didehydro-3-deoxy-L-rhamnonate + H2O => (S)-lactate + H(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018676", "l": "(S)-limonene 7-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65567", "l": "(9Z)-octadecenoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47368", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose = a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP + H(+)"}, {"i": "EC:2.4.1.345", "l": "\"Phosphatidyl-myo-inositol alpha-mannosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48592", "l": "a quinone + formate + H(+) = a quinol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31984", "l": "abieta-7,13-dien-18-ol + O2 + reduced [NADPH--hemoprotein reductase] => abieta-7,13-dien-18,18-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30863", "l": "4-O-phospho-L-tyrosine + H2O = L-tyrosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004938", "l": "alpha2-adrenergic receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-453342", "l": "PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46929", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22531", "l": "a flavonol 3-O-beta-D-glucoside + UDP-beta-L-rhamnose <=> a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40535", "l": "4 H(+) + narbomycin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + novapikromycin + 4 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045518", "l": "interleukin-22 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912362", "l": "MIR150 microRNA binds 3'UTR of NOTCH3 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035226", "l": "glutamate-cysteine ligase catalytic subunit binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32627", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50987", "l": "prostaglandin E2(out) <=> prostaglandin E2(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789077", "l": "Hydrogen peroxide enters the bacterium (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65453", "l": "ethanol + hexanoyl-CoA => CoA + ethyl hexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50672", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O = [(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806610", "l": "Keratin filament formation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30582", "l": "H2O + O-phospho-L-threonine <=> L-threonine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37176", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351208", "l": "Spermidine  => N-acetylated spermidine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54045", "l": "(2E,6E)-farnesyl diphosphate + H2O => 7-epi-alpha-eudesmol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50063", "l": "ATP + glycochenodeoxycholate(in) + H2O <=> ADP + glycochenodeoxycholate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55950", "l": "AH2 + NH4(+) + pyruvate => A + D-alanine + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071734", "l": "biotin-[pyruvate-carboxylase] ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56945", "l": "AH2 + D-ribulose 5-phosphate => 1-deoxy-D-xylulose 5-phosphate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54517", "l": "8-hydroxycopalyl diphosphate => (13R)-manoyl oxide + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59086", "l": "2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+) => 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32899", "l": "1,8-cineole + O2 + reduced [flavodoxin] = 2-endo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [flavodoxin]"}, {"i": "EC:1.14.14.133", "l": "\"1,8-cineole 2-endo-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.20.99.-", "l": "\"With other acceptors\""}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0015407", "l": "ABC-type monosaccharide transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909738", "l": "SHP1 and SHP2 bind the common beta chain (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63433", "l": "1,2,3-tri-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + a di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549129", "l": "OCT1 transports organic cations into hepatic cells (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975111", "l": "TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9   (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63818", "l": "AMP + diphosphate + H(+) + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) => ATP + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810376", "l": "ING2 binds PI5P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209828", "l": "Tryptophan is hydroxylated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42300", "l": "a fatty acyl-[ACP] + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + holo-[ACP]"}, {"i": "EC:2.3.1.n5", "l": "\"Glycerol-3-phosphate acyltransferase (acyl-[acyl-carrier-protein]-transferring)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607744", "l": "MALT1 binds BCL10 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201443", "l": "Type II receptor phosphorylates type I receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55980", "l": "a 1,2-saturated acyl-CoA + an acyl-CoA + H2O = an (R)-2-alkyl-3-oxoalkanoate + 2 CoA + H(+)"}, {"i": "EC:2.3.3.20", "l": "\"Acyl-CoA:acyl-CoA alkyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483218", "l": "PG transports from the ER membrane to the late endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63536", "l": "[des-Arg(9)]-bradykinin + H2O = [des-Phe(8), des-Arg(9)]-bradykinin + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956676", "l": "YAP1 binds TP73 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9656244", "l": "DRD2 binds DA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11438", "l": "4 [Fe(III)cytochrome c] + 2 H2O => 4 [Fe(II)cytochrome c] + 4 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31373", "l": "(2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H(+) + S-adenosyl-L-homocysteine => (2R,3S)-2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021919", "l": "MECP2:CREB1 binds SST gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693061", "l": "STAMBP binds STAM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13340", "l": "D-glucurono-6,2-lactone + H2O <=> D-glucuronate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25331", "l": "(R)-carnitine + NAD(+) => 3-dehydrocarnitine + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41830", "l": "(2E)-hexenoyl-[ACP] + H2O => (3R)-hydroxyhexanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53206", "l": "17beta-hydroxy-3,19-dioxo-5alpha-androstanone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 17beta,19-dihydroxy-3-oxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51874", "l": "diphosphate + osthenol => dimethylallyl diphosphate + umbelliferone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017835", "l": "NOTCH1 coactivator complex binds NOTCH3 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180709", "l": "Association of multimerized Rev with beta-importin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15164", "l": "4-hydroxyphenylacetate + H(+) + NADH + O2 <=> H2O + homogentisate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863472", "l": "DAB2 binds LRP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59286", "l": "D-glucose + N-octadecanoylsphing-4-enine => beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51194", "l": "2-oxoglutarate + H(+) + NADPH => (R)-2-hydroxyglutarate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53302", "l": "H(+) + N-carbamoyl-D-methionine => D-5-[2-(methylsulfanyl)ethyl]hydantoin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51757", "l": "a 2-acyl-4-prenylphloroglucinol + dimethylallyl diphosphate => a 2-acyl-4,6-diprenylphloroglucinol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362551", "l": "Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26228", "l": "abieta-7,13-dien-18-al + H2O + NAD(+) <=> abieta-7,13-dien-18-oate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2130504", "l": "Cleavage of lip22 to lip10 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21049", "l": "ATP + isopropylamine + L-glutamate => ADP + gamma-glutamyl-isopropylamide + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28987", "l": "H(+)(in) + N-acetylneuraminate(in) = H(+)(out) + N-acetylneuraminate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12304", "l": "(S)-2-amino-6-oxohexanoate + H2O + NADP(+) = 2 H(+) + L-2-aminoadipate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102425", "l": "myricetin 3-O-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33316", "l": "a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2214351", "l": "PLK1 phosphorylates GORASP1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19216", "l": "acetyl-CoA + an S-substituted L-cysteine <=> an N-acetyl-L-cysteine-S-conjugate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24607", "l": "7-methylxanthine + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + theobromine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32041", "l": "AMP + ATP + 2 H(+) => H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218811", "l": "DOCK180:ELMO binds CRK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58985", "l": "acrolein + H2O + O2 => acrylate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76373", "l": "N-hydroxylation of 4-aminobiphenyl (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34376", "l": "4-guanidinobutanamide + H2O => 4-guanidinobutanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32410", "l": "(1R,2S,4S)-neoisodihydrocarveol + NAD(+) <=> (1R,4S)-isodihydrocarvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875817", "l": "MET phosphorylates STAT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008650", "l": "rRNA (uridine-2'-O-)-methyltransferase activity"}, {"i": "REACT:R-HSA-6793127", "l": "MRM2 (FTSJ2) methylates uridine-1369 of 16S rRNA yielding 2'-O-methyluridine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046564", "l": "oxalate decarboxylase activity"}, {"i": "RHEA:16509", "l": "H(+) + oxalate = CO2 + formate"}, {"i": "EC:4.1.1.2", "l": "\"Oxalate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28538", "l": "ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A = ADP + H(+) + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24095", "l": "2 H(+) + O2 + 2 sulochrin <=> 2 (2S)-bisdechlorogeodin + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1250280", "l": "ROS oxidize thioredoxin (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59939", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O <=> 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070675", "l": "hypoxanthine oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59401", "l": "L-2-aminohexanoate => D-2-aminohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63557", "l": "dynorphin A-(1-13) + H2O => dynorphin A-(1-12) + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802932", "l": "Dissociation of BRAF/RAF fusion complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42634", "l": "5'-deoxyadenosine + 8-methyladenosine(2503) in 23S rRNA + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine => adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49344", "l": "2-hydroxyspirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2,2-dihydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17945", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.51", "l": "\"(S)-limonene 6-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29179", "l": "a menaquinol + 2 O2 = a menaquinone + 2 H(+) + 2 superoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17282", "l": "(2S)-4-acetamido-2-aminobutanoate => H2O + L-ectoine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14861", "l": "(S)-dihydroorotate + NADP(+) = H(+) + NADPH + orotate"}, {"i": "EC:1.3.1.15", "l": "\"Dihydroorotate dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-868709", "l": "Maltose is converted to trehalose (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32391", "l": "(1R,2R,4R)-dihydrocarveol + NAD(+) = (1R,4R)-dihydrocarvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706304", "l": "Active FLT3 binds to GRAP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0030295", "l": "protein kinase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950721", "l": "Expression of Programmed cell death protein 4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607746", "l": "PKC-delta is activated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60303", "l": "N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20529", "l": "2-cis-(+)-abscisic aldehyde + H2O + O2 = 2-cis-(+)-abscisate + H(+) + H2O2"}, {"i": "EC:1.2.3.14", "l": "\"Abscisic-aldehyde oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018783", "l": "deisopropyldeethylatrazine hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43058", "l": "10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+) => 5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022141", "l": "Prolysyl oxidase activation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54703", "l": "4-hydroxybenzoyl-5'-AMP + holo-[4-hydroxyphenylalkanoate synthase] <=> 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42640", "l": "a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38405", "l": "(9Z,12Z)-octadecadienoate + 1,3-di-(9Z,12Z)-octadecadienoylglycerol + H(+) => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658092", "l": "SIAH1, SIAH2 bind SNCAIP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10340", "l": "(2E,6E)-farnesyl diphosphate = (-)-vetispiradiene + diphosphate"}, {"i": "EC:4.2.3.21", "l": "\"Vetispiradiene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44878", "l": "3-acyl-sn-glycerol + a fatty acid + H(+) => a 1,3-diacylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951644", "l": "Release of mature NEDD8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38592", "l": "devancoaminyl-vancomycin + dTDP-beta-L-4-epi-vancosamine => chloroorienticin B + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61953", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl-[protein] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54491", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine <=> 1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64459", "l": "L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9640167", "l": "RRAGA,B exchanges GDP for GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33766", "l": "a (2E)-enoyl-CoA + H(+) + NADPH <=> a 2,3-saturated acyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983144", "l": "Transport of Antigen peptide in to ER (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391905", "l": "Oxoeicosanoid receptor can bind oxoeicosanoid (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41602", "l": "1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676133", "l": "CD74 binds MIF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20311", "l": "2 H2O + O2 => 2 H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374173", "l": "AGT(34-41) binds to AGTR1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57389", "l": "(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] => (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858498", "l": "SL (surrogate light chain) binds IgH to form pre-BCR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0031856", "l": "parathyroid hormone receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30256", "l": "2 a ubiquinol + O2 => 2 a ubiquinone + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53654", "l": "(5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168849", "l": "tBID binds to inactive BAX protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56762", "l": "4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => 24,25-dihydrolanosterol + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42867", "l": "norspermidine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + norspermine + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203156", "l": "Platelet-derived TREM-1 ligand binds to TREM-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16277", "l": "H2O + indole-3-acetaldehyde + O2 = (indol-3-yl)acetate + H(+) + H2O2"}, {"i": "EC:1.2.3.7", "l": "\"Indole-3-acetaldehyde oxidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050184", "l": "phosphatidylcholine desaturase activity"}, {"i": "KEGG.REACTION:R03475"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47895", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43113", "l": "(R)-mandelate + NAD(+) => H(+) + NADH + phenylglyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15585", "l": "15-cis-phytoene + 4 A = 4 AH2 + all-trans-lycopene"}, {"i": "EC:1.3.99.31", "l": "\"Phytoene desaturase (lycopene-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-744231", "l": "SLC35D2 exchanges UDP-sugars for UMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26054", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] <=> glyceollin III + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018862", "l": "phenylphosphate carboxylase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102670", "l": "2,7,4'-trihydroxyisoflavanone-4'-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-3624"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694625", "l": "nsp3 cleaves nsp1-4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64153", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP-N-acetyl-beta-neuraminate => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001616", "l": "growth hormone secretagogue receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141310", "l": "FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26111", "l": "UDP-N-acetyl-alpha-D-glucosamine = H2O + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose"}, {"i": "EC:4.2.1.115", "l": "\"UDP-N-acetylglucosamine 4,6-dehydratase (inverting)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605768", "l": "Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000122", "l": "CD320 transports extracellular TCII:Cbl to endosome (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390673", "l": "CHRM2,4 bind acetylcholine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61736", "l": "steviolmonoside + UDP-alpha-D-glucose = rubusoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20134", "l": "3-(indol-3-yl)lactate + NAD(+) => H(+) + indole-3-pyruvate + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015621", "l": "ferric triacetylfusarinine C transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.-.-.-", "l": "\"Lyases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975040", "l": "KRAB-ZNF / KAP Interaction (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200143", "l": "AKT phosphorylates AKT1S1 (PRAS40) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426162", "l": "SREBP1A,2 binds the HMGCR promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47812", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-phosphate + NADPH + O2 = 9-ribosyl-trans-zeatin 5'-phosphate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004573", "l": "mannosyl-oligosaccharide glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74718", "l": "Internalisation of the insulin receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53673", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 => 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphoethanolamine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139899", "l": "Sequestration of BAD protein by 14-3-3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879909", "l": "Activation of STAT5a/b by JAK2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28239", "l": "calycosin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + pseudobaptigenin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665284", "l": "Resistant ERBB2 KD mutants do not bind lapatinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5627072", "l": "RHOQ binds GOPC:CFTR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42957", "l": "cytidine(38) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799431", "l": "TP53 binds HIPK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217097", "l": "Formation of the Rad17-RFC alternate clamp-loader complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.5.3", "l": "\"Protoporphyrinogen IX dehydrogenase (quinone)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373724", "l": "Nephrin binds NCK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32259", "l": "beta-D-fructose 1-phosphate + methylglyoxal = 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48242", "l": "CMP + ganglioside GT1b + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1b"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811479", "l": "ING2 recruits EP300 to TP53 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855212", "l": "1/3-PP-IP5 transports from the cytosol to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14076", "l": "3-hydroxy-L-glutamate + H(+) <=> 4-amino-3-hydroxybutanoate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40841", "l": "(2E)-nonenoyl-CoA + FADH2 => FAD + H(+) + nonanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0140036", "l": "ubiquitin-dependent protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940959", "l": "Neurolysin degrades neurotensin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0099530", "l": "G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420243", "l": "GHRH receptor binds GHRH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004613", "l": "phosphoenolpyruvate carboxykinase (GTP) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64554", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418553", "l": "cAMP degradation by Phosphodiesterases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24464", "l": "2-dehydro-3-deoxy-6-phospho-D-galactonate = D-glyceraldehyde 3-phosphate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20462", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + 3 S-adenosyl-L-methionine => an N,N,N-trimethylornithine lipid + 3 H(+) + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047765", "l": "caldesmon-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187506", "l": "Translocation of p27 to the nucleoplasm (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62530", "l": "2 [Fe(III)cytochrome c] + dihydrodigoxin => 2 [Fe(II)cytochrome c] + digoxin + 3 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14730", "l": "beta-D-fructose 1,6-bisphosphate => D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53564", "l": "9,10-epoxy-(12Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-9,10-epoxy-(12Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2328037", "l": "Fibrillin-1 binds integrins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42738", "l": "H(+) + N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25503", "l": "(2E)-geranyl diphosphate <=> diphosphate + terpinolene"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015271", "l": "outward rectifier potassium channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028724", "l": "AMOT proteins bind YAP1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14923", "l": "1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP => (indol-3-yl)acetate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106350", "l": "octaprenyl pyrophosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1852623", "l": "Ubiquitination of NICD1 by FBWX7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13790", "l": "[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27654", "l": "2-oxobutanoate + H(+) + pyruvate = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932020", "l": "GPAM gene expression is stimulated by RUNX1 and ESR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70482", "l": "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357904", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33373", "l": "alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein] => alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13453", "l": "3'-phosphoadenylyl sulfate + quercetin = adenosine 3',5'-bisphosphate + H(+) + quercetin 3-sulfate"}, {"i": "EC:2.8.2.25", "l": "\"Flavonol 3-sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11577", "l": "ATP + thiamine => AMP + H(+) + thiamine diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985943", "l": "p-Y701-STAT1 dimerizes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844617", "l": "IPAF binds procaspase-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10603", "l": "prostaglandin H2 <=> prostaglandin D2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981355", "l": "RASA1 binds RAS:GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250280", "l": "ROS oxidize thioredoxin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655193", "l": "KIAA0101 double monoubiquitination (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59110", "l": "beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol => chenodeoxycholate + octyl beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36681", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH => dTDP-6-deoxy-alpha-D-allose + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43376", "l": "5'-deoxyinosine + phosphate = 5-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0050811", "l": "GABA receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5082391", "l": "Trimerization of HSF1 in the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61965", "l": "2 [Fe(II)-cytochrome b5] + a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a 1-O-(1Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66508", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675790", "l": "MTORC1 dissociates from ULK complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21458", "l": "(S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58916", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + squalene = (S)-2,3-epoxysqualene + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.41"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430180", "l": "NCK recruits WASP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690196", "l": "USP8 deubiquitinates RNF128 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102655", "l": "1-18:1-2-trans-16:1-phosphatidylglycerol desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1222376", "l": "NOX2 generates superoxide from oxygen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015274", "l": "organellar voltage-gated chloride channel activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047233", "l": "N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity"}, {"i": "RHEA:13569", "l": "ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = beta-D-GalNAc-(1->4)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer + H(+) + UDP"}, {"i": "EC:2.4.1.165", "l": "\"N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730840", "l": "Activation of RAC1 by VAV (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850961", "l": "PREX2 binds PTEN and inhibits it (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59496", "l": "(20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + O2 + reduced [NADPH--hemoprotein reductase] = (20S)-ginsenoside C-K + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.3.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64074", "l": "3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 8 CO2 + 9 CoA + 2 H2O => acetyl-CoA + 8 H(+) + holo-[ACP] + 8 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853444", "l": "AURKA phosphorylates PHLDA1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033457", "l": "GAU codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32052", "l": "H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate => adenosine 5'-tetraphosphate + AMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42801", "l": "15-cis-4,4'-diapophytoene + 3 FAD + 3 H(+) => all-trans-4,4'-diaponeurosporene + 3 FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353434", "l": "Formation of Pol zeta complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10856", "l": "a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose = a 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphing-4-enine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299478", "l": "MPP cleaves targeting peptide (presequence) of matrix precursors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66946", "l": "4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + soppiline C => 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + soppiline B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52759", "l": "an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O <=> an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-cysteinylglycine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008043", "l": "MAPK8 phosphorylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11832", "l": "(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) = H(+) + NADH + naphthalene-1,2-diol"}, {"i": "EC:1.3.1.29", "l": "\"Cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38437", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62148", "l": "dGTP + dTMP = dGDP + dTDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.12.1", "l": "\"Dual-specificity kinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071558", "l": "histone H3-tri/di-methyl-lysine-27 demethylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70592", "l": "PXLP-K259-GOT1 dimer deaminates L-Asp (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44713", "l": "a 1,2-diacylglycerol + H2O => a 1-acylglycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45575", "l": "[(1->4)-beta-D-mannuronosyl](n) <=> [alginate](n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353154", "l": "pyruvate + CO2 + ATP => oxaloacetate + ADP + orthophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54842", "l": "H2O + NADP(+) + pentyl propanoate => H(+) + NADPH + O2 + octan-3-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36548", "l": "octadecanoyl-CoA + sphinganine => CoA + H(+) + N-(octadecanoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21154", "l": "cis-4-hydroxy-D-proline => trans-4-hydroxy-L-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000137", "l": "CUBN:AMN transports extracellular CBLIF:Cbl to endosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913371", "l": "GM-CSF receptor alpha:GM-CSF binds Bc (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9653514", "l": "USP17L2 deubiquitinates RCE1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48778", "l": "19-hydroxyprostaglandin H2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin H2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592316", "l": "Initial activation of proMMP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59426", "l": "benzaldehyde + H2O2 + NH4(+) => benzylamine + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31948", "l": "ent-isokaurene + O2 + reduced [NADPH--hemoprotein reductase] => ent-isokauren-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005229", "l": "intracellular calcium activated chloride channel activity"}, {"i": "REACT:R-HSA-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209130", "l": "Full-length SPZ dimer is cleaved by EA/SPE serine protease (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43437", "l": "coproporphyrinogen III + 3 O2 => coproporphyrin III + 3 H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57069", "l": "3-oxoisoapionate + ATP => 3-oxoisoapionate 4-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247844", "l": "Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46100", "l": "11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = cortisol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67110", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034949", "l": "1,1-dichloroethane reductive dehalogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375131", "l": "Basigin binds CD98 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444208", "l": "MLNR (GPR38) is a receptor for motilin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57683", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] <=> a flavone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649701", "l": "NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950752", "l": "IL12A:IL12B translocates from Golgi lumen to late endosome lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31267", "l": "6-hydroxyhexanoate + NADP(+) = 6-oxohexanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045135", "l": "poly(beta-D-mannuronate) lyase activity"}, {"i": "MetaCyc:4.2.2.3-RXN"}, {"i": "EC:4.2.2.3", "l": "\"Mannuronate-specific alginate lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64677", "l": "3-(methylsulfanyl)propanoyl-CoA + butan-1-ol => butyl 3-(methylsulfanyl)propanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010276", "l": "phytol kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18625", "l": "D-galactose + NADP(+) = D-galactono-1,5-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20634", "l": "a (3R)-hydroxyacyl-[ACP] + L-ornithine => a lyso-ornithine lipid + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50227", "l": "3-(all-trans-hexaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050527", "l": "poly(3-hydroxyoctanoate) depolymerase activity"}, {"i": "MetaCyc:3.1.1.76-RXN"}, {"i": "EC:3.1.1.76", "l": "\"Poly(3-hydroxyoctanoate) depolymerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13665", "l": "GTP = 3',5'-cyclic GMP + diphosphate"}, {"i": "EC:4.6.1.2", "l": "\"Guanylate cyclase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42062", "l": "11-cis-retinal + H(+) + NADH => 11-cis-retinol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443831", "l": "14-3-3-zeta binds Raf1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39851", "l": "2 a 1-acyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + glycerol"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005178", "l": "integrin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032566", "l": "dGDP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29005", "l": "H(+)(in) + L-homoserine(out) => H(+)(out) + L-homoserine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36743", "l": "heptadecasphing-4-enine + tetracosenoyl-CoA = CoA + H(+) + N-tetracosenoyl-heptadecasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062153", "l": "C5-methylcytidine-containing RNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55294", "l": "H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine => pseudouridine(54) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41218", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29359", "l": "H2O + UMP = phosphate + uridine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937419", "l": "CBR3 reduces DOX to DOXOL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45320", "l": "H2O + N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine = H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74258", "l": "XDH oxidizes xanthine to form urate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209321", "l": "Phosphorylated STAT92E dissociates from HOP and DOME and dimerises (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0032394", "l": "MHC class Ib receptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052623", "l": "ADP dimethylallyltransferase activity"}, {"i": "MetaCyc:RXN-4305"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45940", "l": "12-methyloctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(13-methyl-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37801", "l": "2 H2O + 2 NAD(+) => 2 H(+) + 2 NADH + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086061", "l": "voltage-gated sodium channel activity involved in bundle of His cell action potential"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42930", "l": "H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine => cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30621", "l": "2 AH2 + all-trans-lycopene => 2 A + all-trans-zeta-carotene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160851", "l": "HAS1,2,3 mediate the polymerisation of HA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174224", "l": "Dissociation of Cdc20 from APC/C complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22872", "l": "2-oxoglutarate + L-prolyl-[collagen] + O2 = CO2 + succinate + trans-3-hydroxy-L-prolyl-[collagen]"}, {"i": "EC:1.14.11.7", "l": "\"Procollagen-proline 3-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34745", "l": "13-methyltetradecanal + phosphoethanolamine => 15-methylhexadecasphinganine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30198", "l": "15,9'-di-cis-phytofluene + plastoquinone-9 <=> 9,9',15-tri-cis-zeta-carotene + plastoquinol-9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19362", "l": "(2E)-geranyl diphosphate + isopentenyl diphosphate => (2E,6E)-farnesyl diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371467", "l": "SIRT1 deacetylates HSF1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621048", "l": "TPH1 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954117", "l": "E2F6:TFDP1 binds EPC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358790", "l": "RNF41 ubiquitinates ERBB3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218642", "l": "PTK2 autophosphorylates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63420", "l": "2-hydroxyethylphosphonate + CTP = cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate"}, {"i": "EC:2.7.7.104", "l": "\"2-hydroxyethylphosphonate cytidylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14190", "l": "D-tryptophan + O2 => N-formyl-D-kynurenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31067", "l": "6-amino-2-oxohexanoate = Delta(1)-piperideine-2-carboxylate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54530", "l": "D-ribose 5-phosphate => aldehydo-D-ribose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065233", "l": "CS is cleaved from its proteoglycan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202724", "l": "P-selectin binds P-selectin ligand (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694539", "l": "nsp15 binds nsp8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374896", "l": "Uptake of Noradrenaline (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35192", "l": "noranthrone + O2 => H2O + norsolorinic acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2530445", "l": "CD59 inhibits MAC formation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862380", "l": "HSD17B13 binds lipid droplets (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38843", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37416", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40279", "l": "(R)-carnitine + dodecanoyl-CoA = CoA + O-dodecanoyl-R-carnitine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004398", "l": "histidine decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63968", "l": "2 3-(4-hydroxyphenyl)pyruvate + H(+) = atromentin + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202291", "l": "Activation of Lck (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51357", "l": "H2O + N-(9Z-octadecenoyl)-L-glutamine => (9Z)-octadecenoate + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018630", "l": "3,5-xylenol methylhydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41210", "l": "1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17931", "l": "ADP + an N-acylsphing-4-enine 1-phosphate + H(+) => an N-acylsphing-4-enine + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15940", "l": "a primary alcohol + NADP(+) <=> an aldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1297354", "l": "Acrosin Cleavage (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604752", "l": "Initial activation of proMMP13 by MMP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34661", "l": "3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine => C30 botryococcene + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19223", "l": "formate + H(+) + methanol => 2 formaldehyde + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25475", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-himachalene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33574", "l": "A + methanol <=> AH2 + formaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-435244", "l": "PECAM1 is phosphorylated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40702", "l": "1-hexadecanoylglycerone 3-phosphate + octadecan-1-ol <=> 1-O-octadecylglycerone 3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51784", "l": "4-prenylphlorisovalerophenone + dimethylallyl diphosphate = deoxyhumulone + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28977", "l": "H(+)(in) + L-asparagine(out) => H(+)(out) + L-asparagine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427514", "l": "eNoSC deacetylates histone H3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047385", "l": "[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47045", "l": "3-dehydrocarnitine + acetyl-CoA => acetoacetate + N,N,N-trimethylglycyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64193", "l": "H2O + N-(9Z-octadecenoyl)-L-lysine => (9Z)-octadecenoate + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59525", "l": "9S,10-epoxy-(10,12Z)-octadecadienoate + H(+) + L-aspartyl-[protein] => 9-O-10-oxo-(12Z)-octadecenoate L-aspartatyl ester-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14636", "l": "ATP + H2O + Na(+)(in) <=> ADP + H(+) + Na(+)(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25483", "l": "acetoacetate + succinyl-CoA <=> acetoacetyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166792", "l": "Conversion of C2 into C2a and C2b (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682377", "l": "LC3 de-lipidation by ATG4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3149519", "l": "MMACHC decyanates CNCbl (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22362", "l": "5-oxo-D-proline + H2O => D-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21510", "l": "H(+) + hexadecanoate + retinol => all-trans-retinyl hexadecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18631", "l": "ADP + H(+) + NADP(+) => ATP + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.9"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0019196", "l": "galactosamine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29327", "l": "(S)-malate(in) + succinate(out) = (S)-malate(out) + succinate(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0052813", "l": "phosphatidylinositol bisphosphate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700154", "l": "Active ALK binds SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694522", "l": "Inner coat assembly and cargo binding (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854222", "l": "TBC1D3 associates with RAB5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58105", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003989", "l": "acetyl-CoA carboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61828", "l": "stigmasterol + UDP-alpha-D-glucose = H(+) + stigmasteryl 3-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798748", "l": "Exocytosis of secretory granule lumen proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25852", "l": "2 [Fe(II)-cytochrome b5] + an 11,12-saturated fatty acyl-CoA + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + an (11Z)-Delta(11)-fatty acyl-CoA + 2 H2O"}, {"i": "EC:1.14.19.5", "l": "\"Acyl-CoA 11-(Z)-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183067", "l": "Localization of CBL:GRB2 to the membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007582", "l": "RAD51 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56781", "l": "(+)-piperitol + O2 + reduced [NADPH--hemoprotein reductase] => (+)-sesamin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67018", "l": "a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + L-lysyl-[protein] => a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983680", "l": "OAS1 produces oligoadenylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37837", "l": "epsilon-rhodomycinone + H2O + NADP(+) => aklavinone + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619838", "l": "ARC binds DNM2 and SH3GL3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0016997", "l": "alpha-sialidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061463", "l": "O-acetyl-ADP-ribose deacetylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9670101", "l": "ATRX:DAXX binds to subtelomeric chromosomal regions (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22269", "l": "ATP + streptomycin => ADP + H(+) + streptomycin 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64815", "l": "acetyl-CoA + S-(2-aminoethyl)-homocysteine <=> CoA + H(+) + S-(2-acetamidoethyl)-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59238", "l": "diphosphate + isoelisabethatriene => (2E,6E,10E)-geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1605723", "l": "Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3132759", "l": "TCN1 binds Cbl (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29384", "l": "dIMP + H2O => 2'-deoxyinosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40021", "l": "(-)-ent-copalol + diphosphate => ent-copalyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77609", "l": "Binding of APOBEC-1 to form editosome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156910", "l": "Formation of eEF1B complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183055", "l": "Binding of CBL to EGFR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633414", "l": "TP53 binds TNFRSF10A,TNFRSF10B,TNFRSF10C,TNFRSF10D genes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61740", "l": "steviolmonoside + UDP-alpha-D-glucose = H(+) + steviolbioside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38095", "l": "gamma-tocotrienol + S-adenosyl-L-methionine = alpha-tocotrienol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781899", "l": "USP13 binds SIAH2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944454", "l": "mTORC1 phosphorylates MAF1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22176", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.94", "l": "\"Leukotriene-B(4) 20-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382096", "l": "Formation of NR-NCOR Corepressor Complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47529", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => isocholate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371518", "l": "SIRT1 binds to HSF1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3878762", "l": "Defective GBE1 does not catalyze branch formation in growing glycogen chains (liver) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42145", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoyl-(4R)-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40274", "l": "O2 + tetradecanedioyl-CoA <=> (2E)-tetradecenedioyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050290", "l": "sphingomyelin phosphodiesterase D activity"}, {"i": "RHEA:20984", "l": "a sphingomyelin + H2O = an N-acylsphing-4-enine 1-phosphate + choline + H(+)"}, {"i": "EC:3.1.4.41", "l": "\"Sphingomyelin phosphodiesterase D\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49928", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874685", "l": "CBL binds MET (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5368279", "l": "MTIF3 binds 28S ribosomal subunit (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12231", "l": "ATP + H2O + L-aspartate + L-glutamine <=> AMP + diphosphate + H(+) + L-asparagine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964773", "l": "OXGR1 binds 2OG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653249", "l": "Cleavage of factor XII variant by activated thrombin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195304", "l": "Association of beta-catenin with the destruction complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781953", "l": "YOD1 binds VCP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15330", "l": "(S)-ureidoglycolate + NAD(+) => H(+) + N-carbamoyl-2-oxoglycine + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430311", "l": "Rsu-1 interacts with Pinch1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52371", "l": "3'-phosphoadenylyl sulfate + cholesterol <=> adenosine 3',5'-bisphosphate + cholesterol sulfate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63833", "l": "(6E)-8-methylnon-6-enoyl-CoA + vanillylamine => capsaicin + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0048038", "l": "quinone binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39068", "l": "3-oxooctanedioyl-CoA + CoA => acetyl-CoA + hexanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050417", "l": "glutamin-(asparagin-)ase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193650", "l": "p75NTR binds to NADE (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190065", "l": "Activated TrkA receptor internalizes to endosomes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205136", "l": "GTP-bound RAC contributes to JNK activation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627350", "l": "SMAC (DIABLO) binds XIAP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390649", "l": "CHRM1,3,5 bind acetylcholine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44849", "l": "(9Z)-tetradecenoyl-CoA + (R)-carnitine => CoA + O-(9Z)-tetradecenoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814678", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9010646", "l": "AKAP5 recruits PKC to ROBO3.1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018478", "l": "malonate-semialdehyde dehydrogenase (acetylating) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13467", "l": "CoA + N(3)-oxalyl-L-2,3-diaminopropanoate => (S)-2,3-diaminopropanoate + oxalyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35429", "l": "cyanidin 3,5-di-O-beta-D-glucoside + E-sinapate => 1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36430", "l": "2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> diphthine-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373867", "l": "BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16111", "l": "ADP + beta-D-fructose 1,6-bisphosphate + H(+) => ATP + beta-D-fructose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13651", "l": "D-glucono-1,5-lactone + H(+) + NADH => beta-D-glucose + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008692", "l": "IL37(?-218) binds SMAD3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.99.1"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047449", "l": "2-dehydro-3-deoxy-L-arabinonate dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10844", "l": "oxaloacetate + pyridoxamine = L-aspartate + pyridoxal"}, {"i": "EC:2.6.1.31", "l": "\"Pyridoxamine--oxaloacetate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9690461", "l": "FKBP1A binds tacrolimus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70272", "l": "PGM:Mg2+ isomerise G6P to G1P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39856", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycerol => a triacyl-sn-glycerol + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674019", "l": "BRAP binds KSR1:MARK3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322429", "l": "XIAP monoubiquinates TLE (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551648", "l": "SUMOylation of TDG with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666001", "l": "Profilin:G-actin binds MKL1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53442", "l": "18-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5665761", "l": "FMNL3 binds RHOC:GTP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381109", "l": "IRE1 binds IRE1 forming dimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57242", "l": "N(2)-(1-hydroxy-2-oxoethyl)-GMP => glyoxal + GMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420274", "l": "GIP receptor binds gastric inhibitory peptide (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9007539", "l": "CHEK1 phosphorylates E2F6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22605", "l": "D-mannose => D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34984", "l": "sulfate(in) => sulfate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.293"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901241", "l": "4-hydroxyphenylacetate transmembrane transporter activity"}, {"i": "RHEA:33175", "l": "4-hydroxyphenylacetate(in) = 4-hydroxyphenylacetate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983142", "l": "Formation of peptide loading complex (PLC) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48703", "l": "H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol <=> a fatty acid + H(+) + long chain acyl-3-O-beta-D-galactosyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31646", "l": "mycinamicin VI + S-adenosyl-L-methionine <=> H(+) + mycinamicin III + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56333", "l": "5'-triphosphoadenylyl-(2'->5')-adenosine + H2O => AMP + ATP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29546", "l": "alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate <=> alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25213", "l": "H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = 2-N,3-O-bis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP"}, {"i": "EC:3.6.1.54", "l": "\"UDP-2,3-diacylglucosamine diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65444", "l": "butanoyl-CoA + hexan-1-ol = CoA + hexyl butanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44095", "l": "ATP + CoA + nonadecanoate <=> AMP + diphosphate + nonadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31032", "l": "2-cis-(+)-abscisate + UDP-alpha-D-glucose => beta-D-glucopyranosyl cis-(+)-abscisate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917693", "l": "ESCRT Disassembly (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665998", "l": "MKL1 binds SRF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43064", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + monacolin J carboxylate = holo-[2-methylbutanoate polyketide synthase] + lovastatin carboxylate"}, {"i": "EC:2.3.1.238", "l": "\"Monacolin J acid methylbutanoate transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.45"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17113", "l": "H2O + L-serine-phosphoethanolamine = H(+) + L-serine + phosphoethanolamine"}, {"i": "EC:3.1.4.13", "l": "\"Serine-ethanolaminephosphate phosphodiesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676041", "l": "Presence of PI(3,5)P2 stimulates the maturation of the early endosome into the late endosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18479", "l": "2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+) => 2,3-dihydroxybenzoate + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031994", "l": "insulin-like growth factor I binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46614", "l": "(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52409", "l": "4-phospho-D-erythronate + NAD(+) => CO2 + dihydroxyacetone phosphate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48231", "l": "a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] <=> a 1-lyso-glycerophospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47507", "l": "chenodeoxycholate + NADP(+) <=> 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679044", "l": "FKBP1A binds sirolimus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.3", "l": "\"Cystinyl aminopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45925", "l": "9-decenoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(2-oxoundec-10-en-1-yl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25215", "l": "2-N,3-O-bis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP => H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660660", "l": "p300 acetylates RELA subunit (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047142", "l": "enzyme-thiol transhydrogenase (glutathione-disulfide) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380241", "l": "glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909721", "l": "Translocation of ISGF3 complex to nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40905", "l": "H(+) + hexadecanoate + sn-glycerol 3-phosphocholine => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59610", "l": "beta-alanine + L-lysine => beta-alanyl-L-lysine + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048407", "l": "platelet-derived growth factor binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052626", "l": "benzoate amino acid synthetase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60621", "l": "N-hexanoyl-sphing-4-enine-1-phosphocholine => choline + N-(hexanoyl)-sphing-4-enine-1,3-cyclic phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13685", "l": "5alpha-cholest-7-en-3beta-ol + NADP(+) = 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14007", "l": "2-oxobutanoate + L-cysteine + NH4(+) => H2O + L,L-cystathionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21857", "l": "cyclohexa-1,5-diene-1-carbonyl-CoA + H2O => 6-hydroxycyclohex-1-ene-1-carbonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43514", "l": "2-carboxy-5-formylfuran + H(+) + H2O2 => 2-(dihydroxymethyl)-5-formylfuran + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27878", "l": "2',3'-cyclic UMP + H2O = 3'-UMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47320", "l": "(S)-3-amino-3-phenylpropanoate + 2-oxoglutarate = 3-oxo-3-phenylpropanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40703", "l": "(9Z,12Z)-octadecadien-1-ol + 1-hexadecanoylglycerone 3-phosphate = 1-O-(9Z,12Z)-octadecadienylglycerone 3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43597", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 => 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693761", "l": "FA2H hydroxylates CERA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53145", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10764", "l": "(2R,3S,4S)-leucocyanidin + 2-oxoglutarate + O2 = (4S)-2,3-dehydroleucocyanidin + CO2 + H(+) + H2O + succinate"}, {"i": "EC:1.14.20.4", "l": "\"Anthocyanidin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213207", "l": "Formation of collagen networks (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114284", "l": "Release of Cytochrome c from mitochondria (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58160", "l": "ent-copalyl diphosphate = diphosphate + dolabradiene"}, {"i": "EC:4.2.3.196", "l": "\"Dolabradiene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372529", "l": "Release of acetylcholine at the synapse (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35200", "l": "(S,S)-tartrate(out) => (S,S)-tartrate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16812", "l": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate <=> pyruvate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12122", "l": "ADP-alpha-D-glucose + diphosphate => alpha-D-glucose 1-phosphate + ATP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36930", "l": "(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42699", "l": "H2O + hercynylselenocysteine <=> NH4(+) + pyruvate + selnoneine thione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799466", "l": "TP53I3 dimerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981728", "l": "Factor H binds to membrane-associated C3b (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65616", "l": "A + cholest-4-en-3-one + H2O = 25-hydroxycholest-4-en-3-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59162", "l": "AMP + diphosphate + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] => ATP + docosanoate + holo-[(phenol)carboxyphthiodiolenone synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785607", "l": "FANCM binds FAAP24 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168888", "l": "Alpha1-Microglobulin binds heme (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28929", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + 2 H(+) => 3,4,5-trihydroxybenzoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848335", "l": "IL37 binds  IL18R1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52889", "l": "N-phenylhydroxylamine + NADP(+) => H(+) + NADPH + nitrosobenzene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.213"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29766", "l": "ATP + H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) <=> ADP + H(+) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247849", "l": "WLS dissociates from retromer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64618", "l": "(E)-coniferyl acetate + CoA => (E)-coniferol + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27281", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) <=> 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52442", "l": "a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174446", "l": "Removal of remaining Flap from the C-strand (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16414", "l": "L-lysyl-[lipoyl-carrier protein] + N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] => (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + L-lysyl-[glycine-cleavage complex H protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49834", "l": "a fatty acid + 2 H(+) + NADH => a fatty aldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035185", "l": "NR1H2,3 binds the NR1H3 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52129", "l": "adenosine-5'-diphospho-5'-(DNA) + H2O => AMP + 2 H(+) + phospho-5'-(DNA)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26307", "l": "2-aminomuconate 6-semialdehyde => 2-aminophenol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.19", "l": "\"Phosphorylase kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28811", "l": "2,3-dioxo-L-gulonate(in) + Na(+)(in) = 2,3-dioxo-L-gulonate(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186778", "l": "SHP2 binds to the active receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54786", "l": "Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide => Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015516", "l": "tartrate:succinate antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65560", "l": "2-oxoglutarate + L-kynurenine = H2O + kynurenate + L-glutamate"}, {"i": "RHEA:65884", "l": "2-oxoglutarate + 3-hydroxy-L-kynurenine = H2O + L-glutamate + xanthurenate"}, {"i": "EC:2.6.1.7", "l": "\"Kynurenine--oxoglutarate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38117", "l": "1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0017040", "l": "N-acylsphingosine amidohydrolase activity"}, {"i": "REACT:R-HSA-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64958", "l": "dTMP + 2 H(+) + 2 phosphate => dTTP + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38343", "l": "(20S)-ginsenoside Rd + H2O = (20S)-ginsenoside Rg3 + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40577", "l": "CoA + glutarate + H(+) => glutaryl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14078", "l": "3-oxopropanoate + L-alanine => beta-alanine + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944242", "l": "Association of procollagen type XXVII (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12331", "l": "[(1->3)-alpha-D-glucosyl](n) + phosphate <=> [(1->3)-alpha-D-glucosyl](n-1) + beta-D-glucose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29670", "l": "H2O(in) <=> H2O(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61722", "l": "a 3-dehydro-D-guloside + H(+) + NADH => a D-guloside + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38723", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70613", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653622", "l": "Defective SLC35A3 does not exchange UDP-GlcNAc for UMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050630", "l": "(iso)eugenol O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.9", "l": "\"Nitroquinoline-N-oxide reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32718", "l": "(2R,3S)-3-methylmalate + NAD(+) <=> 2-oxobutanoate + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33148", "l": "ATP + daunorubicin(in) + H2O => ADP + daunorubicin(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097099", "l": "structural constituent of albumen"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.3.12"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.118", "l": "\"Glucose 1-dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65108", "l": "aculene C + L-prolyl-[peptidyl-carrier protein] = aculene A + holo-[peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55318", "l": "4 H(+) + 3 NADH + sulfite => 3 H2O + hydrogen sulfide + 3 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23479", "l": "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) <=> (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34290", "l": "2 L-dopa + O2 <=> 2 H2O + 2 L-dopaquinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55473", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-diene-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004603", "l": "phenylethanolamine N-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180732", "l": "Translocation of Rev:importin-beta:B23 to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65790", "l": "3-(3,4-dichlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => diuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10143", "l": "NADP(+) + prostaglandin F2alpha <=> H(+) + NADPH + prostaglandin D2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944220", "l": "Association of procollagen type XXIII (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18677", "l": "[Fe(III)-cytochrome b5] + L-ascorbate = [Fe(II)-cytochrome b5] + H(+) + monodehydro-L-ascorbate radical"}, {"i": "EC:1.10.2.1", "l": "\"L-ascorbate--cytochrome-b5 reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17051", "l": "H(+) + S-adenosyl-L-homocysteine + ubiquinol-9 => 3-demethylubiquinol-9 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0070717", "l": "poly-purine tract binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16833", "l": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O"}, {"i": "EC:1.11.1.9", "l": "\"Glutathione peroxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63635", "l": "a long-chain fatty acyl-AMP + holo-[ACP] <=> a long-chain fatty acyl-[ACP] + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047401", "l": "trithionate hydrolase activity"}, {"i": "MetaCyc:3.12.1.1-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45418", "l": "15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+) => 11-oxo-5Z,9,12E,14E-prostatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948136", "l": "ULK1 Translocates to the mitochondria (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785860", "l": "Expression of SOCS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57754", "l": "C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+) => 2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53937", "l": "O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 => 19-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53253", "l": "5alpha-cholest-7-en-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => 5alpha-cholestan-7-oxo-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53718", "l": "phosphate + UDP-N-acetyl-alpha-D-muramate => H(+) + N-acetyl-alpha-D-muramate 1-phosphate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65525", "l": "9-cis-retinal + O2 + reduced [NADPH--hemoprotein reductase] => 9-cis-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32723", "l": "L-trihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-6-(methylsulfanyl)hexanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63043", "l": "H2O + lovastatin <=> H(+) + lovastatin carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1433415", "l": "Activation of RAC1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50937", "l": "(3S)-3-aminobutanoyl-CoA + 2-oxoglutarate => acetoacetyl-CoA + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40946", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5334794", "l": "FABPs bind LCFAs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141341", "l": "SMOX-3 oxidises SPN to SPM (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54487", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphocholine <=> 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44414", "l": "H(+) + S-adenosyl-L-homocysteine + ubiquinol-10 => 3-demethylubiquinol-10 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016084", "l": "myostimulatory hormone activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55036", "l": "an N,N-dimethylornithine lipid + S-adenosyl-L-methionine = an N,N,N-trimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097261", "l": "eoxin C4 synthase activity"}, {"i": "REACT:R-HSA-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603297", "l": "Defective SLC35D1 does not transport UDP-GlcA, UDPGlcNAc (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62683", "l": "YWA1 <=> H(+) + H2O + norrubrofusarin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60958", "l": "(9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + H(+) + UDP => 17-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20722", "l": "CoA + H(+) + L-2-aminoadipate + penicillin G => H2O + isopenicillin N + phenylacetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814695", "l": "PERP binds desmosomes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392513", "l": "Rap1 signal termination by Rap1GAPs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22205", "l": "3-hydroxyphenylacetate + H(+) + NADPH + O2 => H2O + homogentisate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12181", "l": "anthranilate + S-adenosyl-L-methionine => H(+) + N-methylanthranilate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41074", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700175", "l": "Active ALK phosphorylates SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013438", "l": "RHOD binds effectors at the endosome membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65054", "l": "4-(trifluoromethyl)benzaldehyde + H(+) + NADH => 4-(trifluoromethyl)benzyl alcohol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42200", "l": "corticosterone + NADP(+) = 11-dehydrocorticosterone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16317", "l": "(S)-indan-1-ol + NAD(+) = H(+) + indan-1-one + NADH"}, {"i": "RHEA:16321", "l": "(S)-indan-1-ol + NADP(+) = H(+) + indan-1-one + NADPH"}, {"i": "EC:1.1.1.112", "l": "\"Indanol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.7", "l": "\"Interstitial collagenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.149"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084505", "l": "Laminins bind HSPG2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450325", "l": "c-FOS activation by phospho ERK1/2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15147", "l": "alpha,alpha-trehalose => D-maltose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44341", "l": "(S)-2,3-diaminopropanoate + ATP + fumarate => AMP + diphosphate + N(3)-fumaroyl-(S)-2,3-diaminopropanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5225649", "l": "RBBP7 binds histone H3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6804099", "l": "HMGB1 binds LTP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928607", "l": "p-EPHs bind VAV2,3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050148", "l": "nucleotide diphosphokinase activity"}, {"i": "RHEA:12713", "l": "a nucleoside 5'-phosphate + ATP = a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+)"}, {"i": "EC:2.7.6.4", "l": "\"Nucleotide diphosphokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41910", "l": "(2E)-hexadecenoyl-[ACP] + H2O => (3R)-hydroxyhexadecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43699", "l": "H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate <=> diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12460", "l": "(S)-malate = fumarate + H2O"}, {"i": "EC:4.2.1.2", "l": "\"Fumarate hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70494", "l": "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380782", "l": "STAT binds to the active receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061654", "l": "NEDD8 conjugating enzyme activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40820", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61635", "l": "5-aminopentanal + H2O + NAD(+) <=> 5-aminopentanoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033520", "l": "TYSND1 cleaves TYSND1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9693243", "l": "RHOD translocates to the Golgi membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65075", "l": "(2E,6E)-farnesyl diphosphate <=> dauca-4,7-diene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19110", "l": "1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose => 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0098632", "l": "cell-cell adhesion mediator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661086", "l": "Defective SLC9A9 does not exchange Na+ for H+ across the late endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12896", "l": "prostaglandin H2 <=> prostaglandin E2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322431", "l": "XIAP binds TLE (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59056", "l": "2 methanethiol + NAD(+) = dimethyl disulfide + H(+) + NADH"}, {"i": "EC:1.8.1.21", "l": "\"Dissimilatory dimethyldisulfide reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54416", "l": "5alpha-campestan-3-one + NADP(+) = campest-4-en-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981926", "l": "RAC1 and CDC42 activate PAK3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46110", "l": "(2E,6E,10E)-geranylgeranate + 3 H2O + 2 NADP(+) => (2E,6E,10E)-geranylgeraniol + H(+) + 2 NADPH + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70692", "l": "ornithine => putrescine + CO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52757", "l": "an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O => an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-cysteinylglycine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43285", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70596", "l": "GOT2 dimer deaminates L-Asp (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18512", "l": "H(+) + H2O2 + NADH <=> 2 H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791112", "l": "Expression of HDGF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.5.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17154", "l": "CDP-D-glucose => CDP-4-dehydro-6-deoxy-D-glucose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051117", "l": "ATPase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48334", "l": "a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+) => a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42480", "l": "2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + catechol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176298", "l": "Activation of claspin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25923", "l": "A + H2O + quinolin-7-ol <=> 7-hydroxyquinolin-2(1H)-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18122", "l": "an S-substituted L-cysteine + H2O => a thiol + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.32"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211950", "l": "CYP24A1 24-hydroxylates CTL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40441", "l": "6-deoxy-6-sulfo-D-fructose => 6-sulfo-D-quinovose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9698844", "l": "MLKL binds HSP90:CDC37 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450474", "l": "MK2 phosphorylates BRF1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421320", "l": "BMAL1:CLOCK,NPAS2 heterodimer is phosphorylated and translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418553", "l": "cAMP degradation by Phosphodiesterases (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647980", "l": "mature RAS proteins translocate to plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61045", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] => (-)-(R)-19-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004654", "l": "polyribonucleotide nucleotidyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010349", "l": "L-galactose dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47753", "l": "5-hydroxy-3-methyl-L-tyrosine + S-adenosyl-L-methionine => 5-hydroxy-3-methyl-O-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102237", "l": "ATP:farnesol kinase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098973", "l": "structural constituent of postsynaptic actin cytoskeleton"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693575", "l": "DNA-PKcs autophosphorylates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16750", "l": "H2O + phosphonoacetate => acetate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851988", "l": "BTN2A2 binds T cell surface (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102707", "l": "S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615015", "l": "FOXO6 binds PLXNA4 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-350598", "l": "Arginine<=>Agmatine+CO2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013110", "l": "RHOC binds effectors at the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10930", "l": "ent-kaur-16-en-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-al + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62477", "l": "3,4-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] => 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18145", "l": "ATP + beta-D-fructose = ADP + beta-D-fructose 1-phosphate + H(+)"}, {"i": "EC:2.7.1.3", "l": "\"Ketohexokinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102946", "l": "soyasapogenol E UDP-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-9038"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183067", "l": "Localization of CBL:GRB2 to the membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9010872", "l": "SLIT2 binds Dystroglycan (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14912", "l": "L-gulonate + NADP(+) <=> aldehydo-D-glucuronate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17023", "l": "L-alanine + phosphonoacetaldehyde => (2-aminoethyl)phosphonate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27293", "l": "A + formate + H(+) <=> AH2 + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20080", "l": "guanosine(18) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66067", "l": "2-oxohexanoate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682709", "l": "LGI4 binds ADAM22,23,11 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14324", "l": "morphine + NADP(+) <=> H(+) + morphinone + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32197", "l": "abieta-7,13-dien-18-al + H2O => abieta-7,13-dien-18,18-diol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008795", "l": "NAD+ synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23255", "l": "[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O <=> [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781897", "l": "USP11 deubiquitinates NFKBIA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.327", "l": "\"Aclacinomycin-T 2-deoxy-L-fucose transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42070", "l": "clavulanate + NADP(+) => (3R,5R)-clavulanate-9-aldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.18.1", "l": "\"Cathepsin X\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34235", "l": "4-nitro-6-oxohepta-2,4-dienedioate = 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396009", "l": "STING binds c-di-GMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350436", "l": "DGO binds to DSH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602966", "l": "Defective FMO3 does not N-oxidise TMA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400228", "l": "BMAL1 binds CLOCK,NPAS2 forming BMAL1:CLOCK,NPAS2 heterodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61573", "l": "(11Z,14Z)-eicosadienoate + O2 => (15S)-hydroperoxy-(11Z,13E)-eicosadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.-", "l": "\"With other acceptors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26390", "l": "all-trans-beta-carotene + O2 => all-trans-10'-apo-beta-carotenal + beta-ionone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39083", "l": "3-oxododecanedioyl-CoA + CoA = acetyl-CoA + decanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106292", "l": "superoxide-generating NADPH oxidase activity"}, {"i": "RHEA:63180", "l": "NADPH + 2 O2 = H(+) + NADP(+) + 2 superoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25956", "l": "2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) = 3-dehydroquinate + H(+) + NADH + NH4(+)"}, {"i": "EC:1.4.1.24", "l": "\"3-dehydroquinate synthase II\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783530", "l": "gp130:JAKs bind CNTFR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46663", "l": "H(+) + NADPH + progesterone <=> 5beta-pregnan-3,20-dione + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39690", "l": "(R)-3-hydroxy-(11Z)-octadecenoyl-CoA <=> (2E,11Z)-octadecadienoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36149", "l": "benzyl acetate + CoA => acetyl-CoA + benzyl alcohol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12567", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + NAD(+) <=> 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451463", "l": "pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11320", "l": "UDP-beta-L-arabinopyranose = UDP-alpha-D-xylose"}, {"i": "EC:5.1.3.5", "l": "\"UDP-arabinose 4-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59534", "l": "(S)-codamine + H(+) + S-adenosyl-L-homocysteine => (S)-reticuline + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22974", "l": "butanoyl-CoA + H(+) + NADPH => butanal + CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39742", "l": "3-hydroxydodecanoate + H(+) + NADPH + O2 <=> 3,12-dihydroxydodecanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42235", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z)-octadecenoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004044", "l": "amidophosphoribosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5684008", "l": "NBN binds KPNA2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10372", "l": "CoA + NAD(+) + phenylglyoxylate = benzoyl-CoA + CO2 + NADH"}, {"i": "EC:1.2.1.58", "l": "\"Phenylglyoxylate dehydrogenase (acylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026510", "l": "NTF4-bound NTRK2 dimers trans-autophosphorylate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-377640", "l": "Autophosphorylation of SRC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444523", "l": "CXCR5 binds CXCL13 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52335", "l": "2 N(omega)-hydroxy-L-arginine + 2 O2 + reduced [flavodoxin] <=> 3 H(+) + 2 H2O + 2 L-citrulline + 2 nitric oxide + oxidized [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40562", "l": "dTDP-beta-L-evernosamine + NADPH + O2 <=> dTDP-N-hydroxy-beta-L-evernosamine + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939203", "l": "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16683", "l": "3,4-dihydroxyphenylacetate + H2O + NAD(+) => 4-hydroxyphenylacetate + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18279", "l": "a methyl thioether + H(+) + S-adenosyl-L-homocysteine => a thiol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24813", "l": "2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102399", "l": "dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N-methyltransferase activity"}, {"i": "MetaCyc:RXN-13658"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61759", "l": "stevioside + UDP-alpha-D-glucose <=> H(+) + rebaudioside A + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47722", "l": "NH4(+) + xanthine => H(+) + H2O + isoguanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31914", "l": "beta-D-fructose 1,6-bisphosphate + methylglyoxal <=> 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27285", "l": "2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O <=> 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58247", "l": "H2O + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] <=> ADP-D-ribose + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48876", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35147", "l": "(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(in) = (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030110", "l": "HLA-C specific inhibitory MHC class I receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45256", "l": "hexadecanoate(out) = hexadecanoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839091", "l": "Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46851", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+) <=> 5alpha-cholest-8-en-3-one + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102125", "l": "gibberellin A9 16alpha,17 epoxidase activity"}, {"i": "MetaCyc:RXN-11388"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38287", "l": "(3S)-citramalate + succinyl-CoA = (3S)-citramalyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44836", "l": "globoside NORint (d18:1(4E)) + UDP-alpha-D-galactose = globoside NOR2 (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.86", "l": "\"Rhamnogalacturonan acetylesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655142", "l": "RCHY1 binds POLH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23623", "l": "ATP + N(2)-(2-carboxyethyl)-L-arginine <=> AMP + deoxyamidinoproclavaminate + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203611", "l": "N-myristoylation of eNOS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5662620", "l": "MT3 binds cadmium (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103105", "l": "2-oxo-6-methylthiohexanoate aminotransferase activity"}, {"i": "MetaCyc:RXNQT-4345"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033749", "l": "histone H3-methyl-arginine-3 demethylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28308", "l": "beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0005365", "l": "myo-inositol transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22417", "l": "3,4-dihydroxybenzoate + H(+) => catechol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35912", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16303", "l": "ADP-D-ribose + H(+) + nicotinamide => H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21728", "l": "GDP-alpha-D-mannose + H2O + 2 NAD(+) = GDP-alpha-D-mannuronate + 3 H(+) + 2 NADH"}, {"i": "EC:1.1.1.132", "l": "\"GDP-mannose 6-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43559", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41029", "l": "1-O-hexadecyl-2-acetyl-3-tetradecanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008682", "l": "2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity"}, {"i": "RHEA:50908", "l": "a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O"}, {"i": "EC:1.14.99.60", "l": "\"3-demethoxyubiquinol 3-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37611", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28016", "l": "methyl thiocyanate + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + thiocyanate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17995", "l": "ADP + gamma-L-glutamyl-L-cysteinyl-beta-alanine + H(+) + phosphate => ATP + beta-alanine + L-gamma-glutamyl-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46011", "l": "CoA + NAD(+) + pentanal <=> H(+) + NADH + pentanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2130706", "l": "MHC class II antigen processing (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983300", "l": "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49622", "l": "D-erythrulose 1-phosphate + H(+) + NADPH => D-erythritol 1-phosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983138", "l": "Transport of MHC heterotrimer to ER exit site (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850945", "l": "Casein kinase II phosphorylates PTEN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444523", "l": "CXCR5 binds CXCL13 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31811", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + viridiflorene"}, {"i": "EC:4.2.3.88", "l": "\"Viridiflorene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198756", "l": "ERK1/2 phosphorylates MSK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786050", "l": "IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60762", "l": "CoA + jasmolin II => (1R,3R)-pyrethroyl-CoA + (Z,S)-jasmololone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "79.682896251205548", "identifiers": [{"i": "GO:0016722", "l": "oxidoreductase activity, acting on metal ions"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56063", "l": "H(+) + hexadecanoate + hnu <=> CO2 + pentadecane"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8932351", "l": "KEAP1 facilitates ubiquitination of NFE2L2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52485", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + A => (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29197", "l": "a menaquinol + orotate => (S)-dihydroorotate + a menaquinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654167", "l": "Activated FGFR1 binds PLCG1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159796", "l": "Furin cleaves pro-factor IX to factor IX (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34497", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433542", "l": "Phosphorylation and activation of VAV1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10484", "l": "H2O + N-feruloylglycine = (E)-ferulate + glycine"}, {"i": "EC:3.5.1.71", "l": "\"N-feruloylglycine deacylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55259", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65284", "l": "alpha-NeuNAc-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1<->1')-L-Thr-[protein] + CMP-N-acetyl-beta-neuraminate = alpha-NeuNAc-(2->3)-beta-D-Gal-(1->3)-[alpha-NeuNAc-(2->6)]-alpha-D-GalNAc-(1<->1')-L-Thr-[protein] + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102717", "l": "DIBOA-glucoside oxygenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102127", "l": "8-oxoguanine deaminase activity"}, {"i": "MetaCyc:RXN-11455"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31406", "l": "all-trans-4,4'-diapo-zeta-carotene + FAD + H(+) <=> all-trans-4,4'-diaponeurosporene + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59132", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP = AMP + diphosphate + H(+) + staphyloferrin B"}, {"i": "EC:6.3.2.56", "l": "\"Staphyloferrin B synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17044", "l": "adenosine 5'-phosphosulfate + H2O <=> AMP + 2 H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0045289", "l": "luciferin monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39075", "l": "(2E)-dodecenedioyl-CoA + H2O = (3S)-hydroxydodecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10614", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-xylose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803858", "l": "TP53 binds the SFN gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982017", "l": "Active G alpha (q) binds RGS proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.98.2", "l": "\"Dichlorochromopyrrolate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682709", "l": "LGI4 binds ADAM22,23,11 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26131", "l": "(+)-copalyl diphosphate <=> diphosphate + isopimara-7,15-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32872", "l": "a 2-acylglycerol + H2O => a carboxylate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65416", "l": "dGMP(in) + NAD(+)(out) = dGMP(out) + NAD(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111962", "l": "PDE4A,C,D hydrolyse cAMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034790", "l": "3,4-dihydroxy-3,4-dihydrofluorene dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-481044", "l": "Surface deployment of platelet alpha granule membrane components (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050168", "l": "pentanamidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17431", "l": "4-oxocyclohexanecarboxylate + H(+) + NADH => NAD(+) + trans-4-hydroxycyclohexanecarboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55655", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53639", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050323", "l": "taurine dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66065", "l": "2-oxohexanoate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667914", "l": "ALK binds ligand midkine (MDK) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928624", "l": "EPHBs bind EFNBs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65418", "l": "dGMP(out) + NAD(+)(in) => dGMP(in) + NAD(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13184", "l": "ATP + H2O + nitrate(out) <=> ADP + H(+) + nitrate(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53660", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671993", "l": "CIT-3 binds DLG4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62310", "l": "(+)-malbrancheamide B + FADH2 => (+)-premalbrancheamide + chloride + FAD + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102071", "l": "9,10-epoxy-18-hydroxystearate hydrolase activity"}, {"i": "MetaCyc:RXN-1065"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28344", "l": "dIMP + diphosphate + H(+) => dITP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627350", "l": "SMAC (DIABLO) binds XIAP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32363", "l": "L-gulono-1,4-lactone + O2 = H(+) + H2O2 + L-ascorbate"}, {"i": "EC:1.1.3.8", "l": "\"L-gulonolactone oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19966", "l": "S,S-dimethyl-beta-propiothetin => acrylate + dimethyl sulfide + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864595", "l": "TFAP2B homodimer binds YEATS4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14430", "l": "a [oligopeptide](in) + ATP + H2O => a [oligopeptide](out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48129", "l": "(2E,6E)-farnesyl diphosphate + H2O => (2E,6E)-farnesyl phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549129", "l": "OCT1 transports organic cations into hepatic cells (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26535", "l": "3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55376", "l": "2 a quinol + O2 = 2 a quinone + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682026", "l": "MRN bound to shortened telomeres activates ATM (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50517", "l": "acetyl-CoA + N-terminal L-threonyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202541", "l": "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17826", "l": "ATP + D-glucose => ADP + D-glucose 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53221", "l": "16alpha,17alpha-dihydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] => 6beta,16alpha,17alpha-trihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336421", "l": "DT fragment A ADP-ribosylates target cell EEF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981892", "l": "Active G alpha (z) binds RGS proteins (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5679205", "l": "ULK1 phosphorylates Beclin-1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58680", "l": "A + FADH2 = AH2 + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786070", "l": "IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432067", "l": "Aquaporin-4 passively transports water out of cell (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429157", "l": "ABCC4 accumulation of dense granule contents (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000120", "l": "CBLIF binds Cbl (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12429", "l": "2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH => benzene-1,2,4-triol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606564", "l": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901097", "l": "kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL2] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015188", "l": "L-isoleucine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028819", "l": "VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40437", "l": "H(+) + hexadecanoate + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975594", "l": "PLB1 hydrolyses RPALM to atROL (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14103", "l": "[eIF5A protein]-hypusine + A + H2O => [eIF5A protein]-deoxyhypusine + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798372", "l": "ATM phosphorylates DYRK2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018824", "l": "(hydroxyamino)benzene mutase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-996755", "l": "ZFPM proteins bind GATA proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53096", "l": "4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 4-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351894", "l": "Caspase mediated cleavage of BAP31 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18634", "l": "2 ATP + H2O + hydrogencarbonate + L-glutamine => 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63189", "l": "3,4-dihydroxybenzaldehyde + AH2 + tyramine => A + H2O + norbelladine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13306", "l": "E-sinapate + UDP-alpha-D-glucose => 1-O-(trans-sinapoyl)-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033717", "l": "gluconate 2-dehydrogenase (acceptor) activity"}, {"i": "RHEA:12769", "l": "A + D-gluconate = 2-dehydro-D-gluconate + AH2"}, {"i": "EC:1.1.99.3", "l": "\"Gluconate 2-dehydrogenase (acceptor)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49507", "l": "phosphinomethylmalate <=> phosphinomethylisomalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607747", "l": "TRAF6 binds MALT1 oligomers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32758", "l": "(2S)-naringenin + 2-oxoglutarate + O2 <=> apigenin + CO2 + H(+) + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102220", "l": "hydrogenase activity (NAD+, ferredoxin)"}, {"i": "RHEA:30279", "l": "2 H2 + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] = 3 H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.12.1.4", "l": "\"Hydrogenase (NAD(+), ferredoxin)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59842", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-O-methylgallate => (6S)-5,6,7,8-tetrahydrofolate + syringate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418925", "l": "ADORA2A,B bind Ade-Rib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23776", "l": "ATP + L-aspartate = 4-phospho-L-aspartate + ADP"}, {"i": "EC:2.7.2.4", "l": "\"Aspartate kinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004322", "l": "ferroxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17209", "l": "1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O = 2-formylglutarate + NH4(+)"}, {"i": "EC:3.5.2.18", "l": "\"Enamidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170978", "l": "p-FRS2:CRKL binds C3G (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8957241", "l": "TP73 tetramer translocates to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17730", "l": "an acyl-CoA + cholesterol => a cholesterol ester + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19772", "l": "phaseollidin hydrate <=> H2O + phaseollidin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003828", "l": "alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40256", "l": "(2E)-hexadecenedioyl-CoA + H2O => (3R)-hydroxyhexadecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086088", "l": "voltage-gated potassium channel activity involved in Purkinje myocyte action potential repolarization"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388811", "l": "CD28 homodimer binds B7-1 homodimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61587", "l": "cytidine(72) in tRNA(Cys) + S-adenosyl-L-methionine <=> 5-methylcytidine(72) in tRNA(Cys) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64309", "l": "3-aminobutanoate + pyruvate => acetoacetate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624112", "l": "CEBPA binds CDK4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23400", "l": "7,8-dihydroxykynurenate + O2 = 5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+)"}, {"i": "EC:1.13.11.10", "l": "\"7,8-dihydroxykynurenate 8,8a-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-555065", "l": "Formation of clathrin coated vesicle (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66236", "l": "IC-asc-C9-CoA + O2 = H2O2 + IC-asc-DeltaC9-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30292", "l": "(9Z,12Z)-octadecadienoate + O2 => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23160", "l": "L-rhamnopyranose = L-rhamnulose"}, {"i": "EC:5.3.1.14", "l": "\"L-rhamnose isomerase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008880", "l": "glucuronate isomerase activity"}, {"i": "MetaCyc:GLUCUROISOM-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139917", "l": "tBID activates BAX protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11811", "l": "bergaptol + S-adenosyl-L-methionine <=> bergapten + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52271", "l": "3-(aminomethyl)indole + S-adenosyl-L-methionine <=> (1H-indol-3-yl)-N-methylmethanamine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39227", "l": "(2E)-octacosenoyl-CoA + H(+) + NADPH = NADP(+) + octacosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806417", "l": "TP53 binds the DDB2 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809707", "l": "MTMR12 binds MTMR2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24882", "l": "(S)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+) = H(+) + L-glutamate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55203", "l": "5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine <=> 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106105", "l": "Ala-tRNA(Thr) hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35549", "l": "2 H2O + mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin] => cyclo(L-tyrosyl-L-tyrosyl) + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869580", "l": "DEK binds TFAP2A homodimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015333", "l": "peptide:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31993", "l": "diphosphate + sesquithujene => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39155", "l": "(3R)-hydroxyoctadecanoyl-CoA = (2E)-octadecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29956", "l": "H(+)(in) + thymidine(in) => H(+)(out) + thymidine(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0047979", "l": "hexose oxidase activity"}, {"i": "MetaCyc:HEXOSE-OXIDASE-RXN"}, {"i": "EC:1.1.3.5", "l": "\"Hexose oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209278", "l": "Ubiquitinated and phosphorylated CI is partially degraded by the proteasome complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38316", "l": "chorismate => 3-hydroxybenzoate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25543", "l": "ent-copalyl diphosphate <=> diphosphate + ent-pimara-8(14),15-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11020", "l": "1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)"}, {"i": "EC:2.7.1.127", "l": "\"Inositol-trisphosphate 3-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47882", "l": "H(+) + octanoate + octanoylglycerol => dioctanoylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849055", "l": "PTK6 binds ARHGAP35 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65603", "l": "4,5,8-trihydroxycasbene + 2 NAD(+) <=> 2 H(+) + jolkinol C + 2 NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13326", "l": "H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine => 3 H(+) + 2 NADH + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55535", "l": "H(+) + H2O + L-phenylalanine + O2 <=> 2-phenylacetaldehyde + CO2 + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009673", "l": "low-affinity phosphate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12552", "l": "(E)-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA = (E)-pinosylvin + 4 CO2 + 4 CoA"}, {"i": "EC:2.3.1.146", "l": "\"Pinosylvin synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051746", "l": "thalianol synthase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102193", "l": "protein-ribulosamine 3-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40077", "l": "futalosine + NH4(+) => 6-amino-6-deoxyfutalosine + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46497", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(in) => N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103098", "l": "CYP79F1 tetrahomomethionine monooxygenase activity"}, {"i": "MetaCyc:RXNQT-4311"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57203", "l": "glyoxal + L-arginyl-[protein] <=> N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.204"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45990", "l": "3,4,17-trihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMN + H(+) + H2O => 3,17-dihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMNH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111956", "l": "Calmodulin activates Cam-PDE 1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28277", "l": "(S)-S-adenosyl-L-methionine <=> (R)-S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035379", "l": "carbon dioxide transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712082", "l": "ALK fusions phosphorylate IRS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666129", "l": "CDC42:GTP recruits DIAPH2-2 to kinetochores (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186798", "l": "GAP binds to PDGF-beta receptors only (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139895", "l": "tBID activates BAK protein (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33992", "l": "(2E,6E)-farnesyl diphosphate => alpha-copaene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874080", "l": "SRC phosphorylates PTK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70982", "l": "Fumarate + H2O <=> (S)-Malate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65038", "l": "1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912734", "l": "CBL:CRKL binds RAPGEF1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63132", "l": "apo--[alkylcobalamin reductase] + glutathione + methylcob(III)alamin = cob(I)alamin--[alkylcobalamin reductase] + H(+) + S-methyl glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40060", "l": "decanoyl-CoA + H2O => CoA + decanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163310", "l": "TFAM binds to mitochondrial promoters (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35262", "l": "7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O <=> 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34906", "l": "4 glutathione + 2 H(+) + selenite <=> glutathione disulfide + 3 H2O + selenodiglutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19948", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49608", "l": "2-glutathionyl-2-methylbut-3-enal + H2O + NAD(+) = 2-glutathionyl-2-methylbut-3-enoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55156", "l": "a quinone + glutathione + H(+) + hydrogen sulfide = a quinol + S-sulfanylglutathione"}, {"i": "EC:1.8.5.8", "l": "\"Eukaryotic sulfide quinone oxidoreductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19036", "l": "an N-acyl-D-glucosamine <=> an N-acyl-D-mannosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22976", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate"}, {"i": "RHEA:23532", "l": "ATP + cholate + CoA = AMP + choloyl-CoA + diphosphate"}, {"i": "EC:6.2.1.7", "l": "\"Cholate--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388605", "l": "POMC(138-176) binds MC2R (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428531", "l": "Recruitment of PAK to NCK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51339", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> 8-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55943", "l": "all-trans-3,4-didehydroretinol + NAD(+) <=> all-trans-3,4-didehydroretinal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944262", "l": "Association of procollagen type X (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.159", "l": "\"Inositol-1,3,4-trisphosphate 5/6-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189381", "l": "BIL translocates from the cytosol to the ER lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64962", "l": "dTMP + H(+) + phosphate => dTDP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213239", "l": "Formation of MHC II alpha beta heterodimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38687", "l": "(4R)-hydroxysphinganine(in) + ATP + H2O = (4R)-hydroxysphinganine(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392749", "l": "Transport of L1 into endosomes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32610", "l": "(6E)-8-hydroxygeraniol + NADP(+) <=> (6E)-8-hydroxygeranial + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10239", "l": "trans-2-coumarate + UDP-alpha-D-glucose <=> H(+) + trans-beta-D-glucosyl-2-hydroxycinnamate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52132", "l": "adenosine-5'-diphospho-5'-(ribonucleotide)-(DNA) + H2O = 5'-phospho-(ribonucleotide)-(DNA) + AMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005228", "l": "intracellular sodium activated potassium channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411357", "l": "TCF7L1/TCF7L2/LEF1:CTNNB1 promote transcription of the MYC gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28044", "l": "acetyl-CoA + CO2 + NADH => CoA + NAD(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168166", "l": "NFkB complex is transported from cytosol to nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5213464", "l": "RIPK1 is phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865276", "l": "PDGF-AB clevage by Furin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41975", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E)) <=> CMP + ganglioside GT1aalpha (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45024", "l": "cholesterol + H(+) + NADPH + O2 = cholesta-5,7-dien-3beta-ol + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30918", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O <=> a fatty acid + beta-D-glucosyl-(1<->1)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27518", "l": "H2O + sphing-4-enine 1-phosphate = phosphate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65077", "l": "dauca-4,7-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => asperaculane D + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382058", "l": "Nck binds to the active PDGF receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675656", "l": "EDA:EDAR binds EDARADD (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48321", "l": "ganglioside GA1 + GDP-beta-L-fucose => ganglioside Fuc-GA1 + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33144", "l": "galactitol(in) => galactitol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21358", "l": "H(+) + L-ribulose + NADH => L-arabinitol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11067", "l": "beta-D-fructose 1,6-bisphosphate + H2O <=> beta-D-fructose 6-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44449", "l": "an acyl-CoA + H(+) + malonyl-[ACP] => a 3-oxoacyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13668", "l": "GTP <=> 3',5'-cyclic GMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58265", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol => an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106080", "l": "GATOR1 complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47139", "l": "ATP + CoA + lithocholate <=> AMP + diphosphate + lithocholoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49309", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O => a neolactoside nLc4Cer(d18:0) + L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202328", "l": "Translocation of PKC theta to plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814695", "l": "PERP binds desmosomes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809309", "l": "MTMR6 binds MTMR9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13238", "l": "D-fructose 6-phosphate + L-glutamine => D-glucosamine 6-phosphate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54996", "l": "3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53519", "l": "1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> (11Z,14Z,17Z-eicosatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29079", "l": "(R)-lactate + ubiquinone-8 = pyruvate + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810357", "l": "Fillagrin and keratin intermediate filaments polymerise forming a network (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32629", "l": "6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373140", "l": "isocitrate <=> citrate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694442", "l": "CNIH2,3 bind GRIA1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44690", "l": "a fatty acid + glycerol + H(+) => a 2-acylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031892", "l": "type 2 vasoactive intestinal polypeptide receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39021", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427337", "l": "MBD2 binds methylcytosine in chromatin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47118", "l": "H2O + N-eicosanoylglycinate => eicosanoate + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700175", "l": "Active ALK phosphorylates SHC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672011", "l": "p-AMPK:AMP binds the ULK complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70479", "l": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56786", "l": "(6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + (n-1) H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019806", "l": "bromide peroxidase activity"}, {"i": "EC:1.11.1.18", "l": "\"Bromide peroxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13754", "l": "2 L-glutamate + NAD(+) => 2-oxoglutarate + H(+) + L-glutamine + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43067", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + monacolin J carboxylate <=> holo-[2-methylbutanoate polyketide synthase] + lovastatin carboxylate"}]}
{"type": "biolink:MolecularActivity", "ic": "73.539748874002555", "identifiers": [{"i": "GO:0140678", "l": "molecular function inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54396", "l": "1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0043621", "l": "protein self-association"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-921145", "l": "Activated chicken TAK1 dissociates from the activated TLR3 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44636", "l": "2,4-dinitroanisole + H2O = 2,4-dinitrophenol + H(+) + methanol"}, {"i": "EC:3.3.2.14", "l": "\"2,4-dinitroanisole O-demethylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005041", "l": "low-density lipoprotein particle receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49217", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O => 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696564", "l": "USP25 deubiquitinates DDX58 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050255", "l": "ribitol 2-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625883", "l": "PKN1 in complex with AR positively regulates expression of KLK2 and KLK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-744231", "l": "SLC35D2 exchanges UDP-sugars for UMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48239", "l": "2 2-acetylphloroglucinol <=> 1,3,5-trihydroxybenzene + 2,4-diacetylphloroglucinol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54568", "l": "a uridine in rRNA = a pseudouridine in rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14290", "l": "a dicarboxylate + ATP + CoA => AMP + diphosphate + omega-dicarboxyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57947", "l": "H(+) + H2O2 + harderoheme III <=> CO2 + 2 H2O + heme b"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692755", "l": "CDK1 phosphorylates MAPK6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39803", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+) = (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48441", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => a fatty acid + H(+) + long chain 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051675", "l": "isopullulanase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22415", "l": "anthranilate + ATP <=> diphosphate + N-adenylylanthranilate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25408", "l": "ADP-alpha-D-glucose + D-glucose = ADP + alpha,alpha-trehalose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2029471", "l": "Hydrolysis of PC to PA by PLD (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17066", "l": "(R)-mevalonate + ATP => (R)-5-phosphomevalonate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977136", "l": "Amyloid precursor proteins form ordered fibrils (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31910", "l": "(S)-norcoclaurine + S-adenosyl-L-methionine <=> (S)-coclaurine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17089", "l": "2-dehydro-3-deoxy-6-phospho-D-gluconate = D-glyceraldehyde 3-phosphate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201521", "l": "ALK autophosphorylation downstream of PTN and MDK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11298", "l": "2-oxoglutarate + 2 H(+) + NADPH => 2,5-dioxopentanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65617", "l": "A + cholest-4-en-3-one + H2O => 25-hydroxycholest-4-en-3-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666430", "l": "p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2328037", "l": "Fibrillin-1 binds integrins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32986", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + 2 H2O <=> 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-1D-myo-inositol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52962", "l": "hyocholoyl-24-O-(beta-D-glucuronate) + UDP => hyocholate + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15449", "l": "homogentisate + O2 = 4-maleylacetoacetate + H(+)"}, {"i": "EC:1.13.11.5", "l": "\"Homogentisate 1,2-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30203", "l": "H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate = 2 GDP + 2 H(+)"}, {"i": "EC:3.6.1.41", "l": "\"Bis(5'-nucleosyl)-tetraphosphatase (symmetrical)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32182", "l": "(S)-2,3-dihydrodipicolinate + NAD(+) <=> dipicolinate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19907", "l": "dehydrospermidine + H(+) + NADH => NAD(+) + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371567", "l": "DBC1 is phosphorylated by ATM/ART (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28347", "l": "7,8-dihydroneopterin 3'-triphosphate => 7,8-dihydromonapterin 3'-triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045486", "l": "naringenin 3-dioxygenase activity"}, {"i": "RHEA:18621", "l": "2-oxoglutarate + a (2S)-flavan-4-one + O2 = a (2R,3R)-dihydroflavonol + CO2 + succinate"}, {"i": "EC:1.14.11.9", "l": "\"Flavanone 3-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.91", "l": "\"Flavivirin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61964", "l": "2 [Fe(II)-cytochrome b5] + a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a 1-O-(1Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38160", "l": "(2S,3S)-hydroxyarginine => (2S,3R)-capreomycidine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199299", "l": "AKT phosphorylates FOXO transcription factors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62015", "l": "cytidine(2499) in 23S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(2499) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5669013", "l": "EDA-3 binds EDA2R (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451283", "l": "kainate receptor binds glutamate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247839", "l": "Retromer associates with WLS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047256", "l": "lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40020", "l": "ent-copalyl diphosphate + H2O => (-)-ent-copalol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46710", "l": "AMP + H(+) + salicyl-[non-ribosomal peptide synthase] => 2-hydroxybenzoyl-5'-AMP + holo-[non-ribosomal peptide synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982807", "l": "JAK2 phosphorylation of GHR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9017491", "l": "RHOJ GEFs activate RHOJ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48971", "l": "[thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2 <=> [thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3134946", "l": "DDX41 ubiquitination by TRIM21 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047037", "l": "salutaridine reductase (NADPH) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803255", "l": "HCOOH translocated from mitochondrial matrix to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59033", "l": "(Z)-24-ethylidenelophenol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30596", "l": "4-hydroxyphenylacetate + FADH2 + O2 => 3,4-dihydroxyphenylacetate + FAD + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63722", "l": "losartan-2-N-beta-D-glucuronide + UDP => losartan + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "76.711710297129045", "identifiers": [{"i": "GO:0016684", "l": "oxidoreductase activity, acting on peroxide as acceptor"}, {"i": "EC:1.11.-.-", "l": "\"Acting on a peroxide as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29188", "l": "succinate + ubiquinone-8 => fumarate + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65313", "l": "an ultra-long-chain mono-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] => a 3-oxo-ultra-long-chain mono-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58087", "l": "1-(13Z-docosenoyl)-glycerol + H2O <=> (13Z)-docosenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030341", "l": "chondroitin AC lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318563", "l": "Defective MTRR does not convert cob(II)alamin to MeCbl (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47328", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.72", "l": "\"Fibrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8871260", "l": "YAP1 binds TEAD2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53482", "l": "5alpha-androstane-3beta,17beta-diol + NADP(+) => 3beta-hydroxy-5alpha-androstan-17-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702570", "l": "KW2449-resistant FLT3 mutants don't bind KW2449 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636128", "l": "Translocation of SCP, Triplex (TRI) complex, CVC complex, and Accessory Proteins from the cytoplasm into the nucleous (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694563", "l": "ABHD10 hydrolyses MPAG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56999", "l": "aldehydo-D-apiose <=> apulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191402", "l": "Reduction of presqualene diphosphate to form squalene (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626938", "l": "Beta-catenin binds SOX proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24736", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde => 2-oxoglutarate + 4-hydroxybutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27526", "l": "(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesol + diphosphate"}, {"i": "EC:3.1.7.6", "l": "\"Farnesyl diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202726", "l": "F11R dimerises (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50451", "l": "AH2 + prostaglandin G3 <=> A + H2O + prostaglandin H3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018794", "l": "RHOV binds effectors at the plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28546", "l": "D-glucose = D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190141", "l": "ALAD binds to Pb2+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20243", "l": "N-methylnicotinate + S-adenosyl-L-homocysteine => nicotinate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28221", "l": "chloride + H(+) + H2O2 <=> H2O + hypochlorous acid"}]}
{"type": "biolink:MolecularActivity", "ic": "77.690207805941611", "identifiers": [{"i": "GO:0140303", "l": "intramembrane lipid transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5606996", "l": "Soluble PROCR binds activated protein C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209960", "l": "Diiodinated tyrosine can be deiodinated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40041", "l": "2 ADP + 2 H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 phosphate => 2 ATP + 2 L-glutamate + N-acetyl-L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49295", "l": "D-cellobiose(out) + N(pros)-phospho-L-histidyl-[protein] <=> 6-phospho-beta-D-glucosyl-(1->4)-D-glucose(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.375", "l": "\"Rhamnogalacturonan I galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59287", "l": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O <=> D-glucose + N-octadecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54427", "l": "L-aspartyl-[protein] + NAD(+) <=> 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043871", "l": "delta1-piperideine-6-carboxylate dehydrogenase activity"}, {"i": "RHEA:49476", "l": "2 H2O + L-1-piperideine-6-carboxylate + NAD(+) = H(+) + L-2-aminoadipate + NADH"}, {"i": "MetaCyc:RXN-8162"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203716", "l": "eNOS:Caveolin-1 complex binds to Nostrin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.222", "l": "\"O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50529", "l": "acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008384", "l": "IkappaB kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60327", "l": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102885", "l": "alpha-cuprenene synthase activity"}, {"i": "MetaCyc:RXN-8426"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.319", "l": "\"Isoeugenol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672948", "l": "MARK3 phosphorylates KSR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63935", "l": "abscisate(in) + ATP + H2O <=> abscisate(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624951", "l": "TNPO1 binds KIF17 dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.47", "l": "\"(S)-hydroxynitrile lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53678", "l": "2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61146", "l": "H(+) + myricetin 3-O-alpha-L-rhamnoside + UDP => myricetin + UDP-beta-L-rhamnose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046577", "l": "long-chain-alcohol oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607722", "l": "Active NIK phosphorylates IKKA dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40323", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48830", "l": "benzene-1,2,4-triol + H2O + NADP(+) => H(+) + NADPH + O2 + resorcinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55271", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate <=> (R)-glycerate + alpha-D-glucose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1235037", "l": "Expression of VEGFA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37607", "l": "(6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28748", "l": "NH4(+)(in) => NH4(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098505", "l": "G-rich strand telomeric DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35250", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA(in) + ATP + H2O <=> ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26413", "l": "H2O + N-acetyl-D-muramate 6-phosphate <=> (R)-lactate + N-acetyl-D-glucosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964274", "l": "G alpha (12) binds BTK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22763", "l": "Cypridina luciferin + O2 <=> CO2 + hnu + oxidized Cypridina luciferin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004589", "l": "orotate reductase (NADH) activity"}, {"i": "MetaCyc:OROTATE-REDUCTASE-NADH-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62177", "l": "GDP-alpha-D-glucose + H2O => alpha-D-glucose 1-phosphate + GMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204434", "l": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45244", "l": "(3E,5Z)-octadienoyl-CoA = (2E,4E)-octadienoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848436", "l": "PTK6 phosphorylates CDKN1B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40227", "l": "3'-phosphoadenylyl sulfate + desulfo-A47934 = A47934 + adenosine 3',5'-bisphosphate + H(+)"}, {"i": "EC:2.8.2.36", "l": "\"Desulfo-A47934 sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16971", "l": "dTDP-4-dehydro-beta-L-rhamnose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30332", "l": "all-trans-beta-carotene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => all-trans-zeaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26351", "l": "L-galactose + phosphate => beta-L-galactose 1-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015612", "l": "ABC-type L-arabinose transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848713", "l": "PTK6 binds BCAR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.2.6", "l": "\"Hydroxylamine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47814", "l": "9-ribosyl-trans-zeatin 5'-phosphate + H2O + NADP(+) => H(+) + N(6)-(dimethylallyl)adenosine 5'-phosphate + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.2.3", "l": "\"Thiazoline synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1028817", "l": "CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50208", "l": "cortisol + NAD(+) = cortisone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44238", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46476", "l": "4alpha-hydroxymethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1912357", "l": "ITCH ubiquitinates DTX (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.12.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29802", "l": "ATP + D-allose(out) + H2O <=> ADP + D-allose(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109700", "l": "AKT2 binds PIP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57718", "l": "carbamate + H(+) + H2O => hydrogencarbonate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44375", "l": "Cr(6+) + 2 NADH + O2 <=> Cr(3+) + 2 H(+) + 2 NAD(+) + superoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52902", "l": "15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate => 3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36891", "l": "(9Z,12Z)-octadecadienoyl-CoA + AH2 + O2 = (9Z,12Z,15Z)-octadecatrienoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693608", "l": "Initial resection of double-strand break ends (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71849", "l": "LDH tetramer reduces PYR to LACT (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47098", "l": "(2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate => (2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48349", "l": "a uridine in RNA => a pseudouridine in RNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47302", "l": "(2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (9Z)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614787", "l": "MPZ gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59438", "l": "4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AMP + diphosphate => 4-amino-L-phenylalanine + ATP + holo-[peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209944", "l": "25(OH)D binds GC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54341", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine => 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390087", "l": "WTS binds to SAV (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878054", "l": "HIPK2 phosphorylates RUNX1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199144", "l": "Nectin 2 binds CD226 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35043", "l": "N-(4-aminobenzoyl)-L-glutamate(in) = N-(4-aminobenzoyl)-L-glutamate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16582", "l": "2 [Fe(II)cytochrome c] + 2 H(+) + H2O2 => 2 [Fe(III)cytochrome c] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034536", "l": "2-hydroxy-8-methylchromene-2-carboxylate isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46853", "l": "5alpha-cholest-8-en-3-one + H(+) + NADPH => 5alpha-cholest-8-en-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51661", "l": "an N-(1,2-saturated acyl)sphinganine + H(+) + NADPH + O2 => an N-(2-hydroxyacyl)-sphinganine + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14066", "l": "scyllo-inosose => 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49942", "l": "(10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2 => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000319", "l": "BORA binds PLK1 and AURKA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018794", "l": "RHOV binds effectors at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21061", "l": "3,4-dichloroaniline + malonyl-CoA => CoA + N-(3,4-dichlorophenyl)malonamate"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0016888", "l": "endodeoxyribonuclease activity, producing 5'-phosphomonoesters"}, {"i": "REACT:R-HSA-912368", "l": "SPO11 hydrolyzes DNA forming double-strand breaks (Homo sapiens)"}, {"i": "EC:3.1.21.-", "l": "\"Endodeoxyribonucleases producing 5'-phosphomonoesters\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090433", "l": "palmitoyl-CoA ligase activity"}, {"i": "REACT:R-HSA-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40547", "l": "10-deoxymethymycin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + novamethymycin + 4 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:1901236", "l": "4-(trimethylammonio)butanoate transmembrane transporter activity"}, {"i": "RHEA:32835", "l": "4-(trimethylamino)butanoate(in) = 4-(trimethylamino)butanoate(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001409", "l": "guanine nucleotide transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65128", "l": "1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59695", "l": "D-cellotriono-1,5-lactone + H2O <=> D-cellotrionate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16492", "l": "(R)-prunasin + H2O <=> D-glucose + mandelonitrile"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41825", "l": "3-oxohexanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyhexanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15661", "l": "(E)-4-coumaroyl-CoA + an anthocyanidin 3,5-di-O-beta-D-glucoside = an anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] + CoA"}, {"i": "EC:2.3.1.153", "l": "\"Anthocyanin 5-(6'''-hydroxycinnamoyltransferase)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11482", "l": "3,4-dihydroxybenzoate + H2O + NADP(+) => 3-hydroxybenzoate + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49904", "l": "(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H(+) + O2 = (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO2 + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64261", "l": "(9Z,12Z)-octadecadienoyl-CoA + glycine => CoA + H(+) + N-(9Z,12Z-octadecadienoyl)-glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851988", "l": "BTN2A2 binds T cell surface (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37589", "l": "6-amino-2-oxohexanoate + L-glutamate => 2-oxoglutarate + D-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13796", "l": "2-methyleneglutarate <=> 2-methylene-3-methylsuccinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5250947", "l": "B-WICH complex binds rDNA promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46333", "l": "2 [Fe(II)-cytochrome b5] + a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8862300", "l": "LYZ binds bacterial peptidoglycan (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.165"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.30"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351948", "l": "Mitochondrial recruitment of Drp1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009936", "l": "RNASEL cleaves cellular ssRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63088", "l": "a ribonucleotide in U6 snRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in U6 snRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682377", "l": "LC3 de-lipidation by ATG4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58285", "l": "5,6-dihydrothymine + NADP(+) => H(+) + NADPH + thymine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62335", "l": "ADP + ATP <=> adenosine 3'-diphosphate,5'-diphosphate + AMP"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0052742", "l": "phosphatidylinositol kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37945", "l": "12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O => (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27470", "l": "H2O + N,N'-diacetylchitobiose => acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20492", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala) <=> 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10326", "l": "a 2-hydroxycarbonyl + H(+) + NADPH => an L-glycol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26029", "l": "3-aminopropanal + H2O2 + N-acetylputrescine => H2O + N(1)-acetylspermidine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016290", "l": "palmitoyl-CoA hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52012", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61909", "l": "2 ATP + benzoate + L-phenylalanine + N-benzoyl-L-phenylalaninol => 2 AMP + asperphenamate + 2 diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62256", "l": "Cd(2+)(out) + 2 hydrogencarbonate(out) = Cd(2+)(in) + 2 hydrogencarbonate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32284", "l": "3-hydroxyanthranilate + O2 => H(+) + H2O + quinolinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17020", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA <=> (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41179", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372726", "l": "aspartate [mitochondrial matrix] + glutamate [cytosol] <=> aspartate [cytosol] + glutamate [mitochondrial matrix] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676593", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33560", "l": "an acyl-CoA + sn-glycerol 3-phosphate => a 2-acyl-sn-glycerol 3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004066", "l": "asparagine synthase (glutamine-hydrolyzing) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14951", "l": "2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2 => A + H2O + quinoline-4-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45890", "l": "4-hydroxy-6-(11-methyldodecyl)-pyran-2-one + 2 CO2 + 3 CoA => 12-methyltridecanoyl-CoA + 2 H(+) + 2 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53647", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-corvol ether B + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20327", "l": "N-acetoxy-4-aminobiphenyl => N-hydroxy-4-acetylaminobiphenyl"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57573", "l": "7-deoxyloganetic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] => 7-deoxyloganetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55489", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626549", "l": "IQGAPs bind CALM1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-606289", "l": "New CENPA-containing nucleosomes are deposited at the centromere (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008098", "l": "5S rRNA primary transcript binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047754", "l": "choline sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8957389", "l": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49676", "l": "H(+) + L-methionyl(47)-[F-actin] + NADPH + O2 = H2O + L-methionyl(47)-(R)-S-oxide-[F-actin] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174124", "l": "Dephosphorylation of phospho-Cdh1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097358", "l": "D-leucyl-tRNA(Leu) deacylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74712", "l": "Dissociation of IRS-P from insulin receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10195", "l": "ATP + H2O + sulfate(out) <=> ADP + H(+) + phosphate + sulfate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66856", "l": "(2E)-geranyl diphosphate + 3 isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34030", "l": "3,3'-bipyridine-2,2',5,5',6,6'-hexol + NADP(+) <=> (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24956", "l": "H2O + N-acetyl-beta-D-muramate 6-phosphate = (R)-lactate + N-acetyl-beta-D-glucosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210769", "l": "HNF6- and FGF10-dependent synthesis of PDX1 protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.254", "l": "\"N-terminal methionine N(alpha)-acetyltransferase NatB\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.332", "l": "\"Bacteriochlorophyllide d C-8(2)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30632", "l": "alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucuronate => beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72697", "l": "Start codon recognition (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050101", "l": "mimosinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66908", "l": "acetyl-CoA + 20 H(+) + 9 malonyl-CoA + 13 NADPH + S-adenosyl-L-methionine = 9 CO2 + 10 CoA + 7 H2O + 13 NADP(+) + S-adenosyl-L-homocysteine + soppiline A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53433", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58324", "l": "beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429860", "l": "DCP1-DCP2 complex decaps mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48280", "l": "ganglioside GM2 + UDP-alpha-D-galactose = ganglioside GM1 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.5", "l": "\"Prolyl aminopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655277", "l": "Activated FGFR3 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0048531", "l": "beta-1,3-galactosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693347", "l": "CRYM reduces P2C to PPCA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "55.548492847335282", "identifiers": [{"i": "GO:0097159", "l": "organic cyclic compound binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6805811", "l": "Release of SEPT4 from mitochondria (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052688", "l": "(3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity"}, {"i": "KEGG.REACTION:R06515"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50031", "l": "H2O + tetradecanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + tetradecanoyl-4'-phosphopantetheine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39825", "l": "2-hydroxyeicosanoate + 2 [Fe(III)-cytochrome b5] + H2O => 2 [Fe(II)-cytochrome b5] + eicosanoate + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53460", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53226", "l": "3beta,16alpha-dihydroxy-androst-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 16alpha,17alpha-dihydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007901", "l": "IL1F10 binds IL1RL2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18760", "l": "2-oxoglutarate + 7-deoxycylindrospermopsin + O2 <=> CO2 + cylindrospermopsin + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18310", "l": "an N-acyl-D-amino acid + H2O => a carboxylate + a D-alpha-amino acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853792", "l": "RET tyrosine phosphorylation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64213", "l": "an N-(fatty acyl)-L-isoleucine + H2O => a fatty acid + L-isoleucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102431", "l": "acyl-lipid omega-(9-4) desaturase"}, {"i": "RHEA:46236", "l": "2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373711", "l": "DCC interaction with Netrin-1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19583", "l": "discadenine + H(+) + S-methyl-5'-thioadenosine => N(6)-dimethylallyladenine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10325", "l": "an L-glycol + NADP(+) => a 2-hydroxycarbonyl + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11414", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+) => 6-hydroxymethyl-7,8-dihydropterin + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56550", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47424", "l": "(2E,9Z)-octadecadienoyl-CoA + H2O = (3S)-hydroxy-(9Z-octadecenoyl)-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061784", "l": "peptidoglycan N-acetylglucosaminidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53328", "l": "H2O + UDP-2,3-diacyl-alpha-D-glucosamine = 2,3-diacyl-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296244", "l": "SUCNR1 binds SUCCA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49810", "l": "a quinol + butanal => a quinone + butan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31625", "l": "H(+) + L-oleandrosyl-oleandolide + S-adenosyl-L-homocysteine => L-olivosyl-oleandolide + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404144", "l": "Parenchymal atROL translocates to HSCs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30968", "l": "9,9',15-tri-cis-zeta-carotene => 9,9'-di-cis-zeta-carotene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621370", "l": "SYK autophosphorylates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11357", "l": "A + H(+) + NADH => AH2 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25744", "l": "H(+) + N,N-dihydroxy-L-pentahomomethionine => (E)-8-(methylsulfanyl)octanal oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36411", "l": "cholesta-5,7-dien-3beta-ol + hnu = calciol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030763", "l": "isobutyraldoxime O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45638", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13659", "l": "acetate + H(+) + holo-[citrate lyase ACP] => acetyl-[citrate lyase ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.18", "l": "\"Malonate-semialdehyde dehydrogenase (acetylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691154", "l": "HFE binds TFRC dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58245", "l": "H2O + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] => ADP-D-ribose + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392143", "l": "NO binds to Guanylate Cyclase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46925", "l": "(R)-2-hydroxy-4-methylpentanoyl-CoA => 4-methylpent-2-enoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017064", "l": "fatty acid amide hydrolase activity"}, {"i": "REACT:R-HSA-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Homo sapiens)"}, {"i": "REACT:R-HSA-5693751", "l": "FAAH2 hydrolyses AEA to AA and ETA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17331", "l": "(1R,4R)-camphor + H(+) + NADH => (1R,2S,4R)-borneol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16387", "l": "CO2 + H2O + hydroquinone + NADP(+) => 4-hydroxybenzoate + 2 H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23331", "l": "a 9-cis-epoxycarotenoid + O2 <=> 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029453", "l": "Phosphorylation of VAV (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47277", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202534", "l": "Ubiquitination of NEMO by TRAF6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30905", "l": "H(+) + S-adenosyl-L-homocysteine + spheroidene => demethylspheroidene + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32474", "l": "demethylsuberosin + O2 + reduced [NADPH--hemoprotein reductase] <=> (7S)-marmesin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372449", "l": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-350598", "l": "Arginine<=>Agmatine+CO2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54307", "l": "n 3'-phosphoadenylyl sulfate + dermatan 4'-sulfate <=> n adenosine 3',5'-bisphosphate + dermatan 4',6'-disulfate + n H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20037", "l": "D-sorbitol 6-phosphate + NADP(+) = aldehydo-D-glucose 6-phosphate + H(+) + NADPH"}, {"i": "EC:1.1.1.200", "l": "\"Aldose-6-phosphate reductase (NADPH)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043833", "l": "methylamine-specific methylcobalamin:coenzyme M methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432010", "l": "Aquaporin-1 passively transports water into cell (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58042", "l": "(9Z,12Z,15Z)-octadecatrienoate + glycerol + H(+) => 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17466", "l": "H2O + quercitrin => L-rhamnopyranose + quercetin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851011", "l": "TRIM27 polyubiquitinates PTEN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24401", "l": "ATP + UMP => ADP + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0018271", "l": "biotin-protein ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32994", "l": "2 a 1-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788571", "l": "STAT1,STAT3,STAT6 bind IL13:IL13R type II (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64385", "l": "H2O + N-acetyl-beta-D-6-sulfogalactosaminyl-(1->4)-alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine => alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine + N-acetyl-D-6-sulfogalactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12996", "l": "cyclohex-1-ene-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> cyclohexa-1,5-diene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58632", "l": "N-tetradecanoyl-(2S)-hydroxyglycine = glyoxylate + tetradecamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33963", "l": "ATP + isopentenyl phosphate = ADP + isopentenyl diphosphate"}, {"i": "EC:2.7.4.26", "l": "\"Isopentenyl phosphate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180555", "l": "Association of APOBEC3G:Vif with the Cul5-SCF complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578965", "l": "TNRC6A binds AGO2:miRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15082", "l": "acetate + ATP + CoA => acetyl-CoA + ADP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878914", "l": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682009", "l": "ZCRB1 binds 5'UTR of SARS-CoV-1 genomic RNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018826", "l": "RHOT2 hydrolyzes GTP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102045", "l": "3-chlorobenzoate-3,4-oxygenase activity"}, {"i": "MetaCyc:RXN-10422"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0030597", "l": "RNA glycosylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3828025", "l": "DCN (decorin) degradation by MMP14 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008683", "l": "2-oxoglutarate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19379", "l": "2 H(+) + NADPH + riboflavin => NADP(+) + reduced riboflavin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-203611", "l": "N-myristoylation of eNOS (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018755", "l": "2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5631885", "l": "PRDX1 overoxidizes (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388814", "l": "Grb2 binds CD28 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685602", "l": "NCR3LG1 binds NCR3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53195", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O <=> 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37853", "l": "13-dihydrodaunorubicin + H2O + NADP(+) => 13-deoxydaunorubicin + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450088", "l": "GLUT1 tetramer binds 4xATP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66755", "l": "(2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(in) + ATP + H2O <=> (2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75244", "l": "FASL binds FAS Receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53764", "l": "allocholate + lithocholoyl-CoA = allocholoyl-CoA + lithocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28091", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032018", "l": "2-methylbutanol:NADP oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49141", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018503", "l": "trans-1,2-dihydrodiolphenanthrene dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55176", "l": "2-oxoglutarate + butanoyl-CoA + O2 = 2-hydroxybutanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186773", "l": "PDGF dimer binds two receptors simultaneously (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10793", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0001716", "l": "L-amino-acid oxidase activity"}, {"i": "MetaCyc:L-AMINO-ACID-OXIDASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64097", "l": "3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] => 2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047001", "l": "2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047109", "l": "(S)-3-hydroxyacid-ester dehydrogenase activity"}, {"i": "RHEA:18269", "l": "ethyl (S)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + H(+) + NADPH"}, {"i": "EC:1.1.1.280", "l": "\"(S)-3-hydroxyacid-ester dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50571", "l": "acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018753", "l": "cyanuric acid amidohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44049", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => 8,9-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36859", "l": "(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62907", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc derivative + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58074", "l": "a jasmonate + NADP(+) => a 4,5-didehydrojasmonate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31855", "l": "(S)-2,3-epoxysqualene = achilleol B"}, {"i": "EC:5.4.99.48", "l": "\"Achilleol B synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40595", "l": "dodecanedioyl-CoA + H2O = CoA + dodecanedioate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50095", "l": "a fatty acyl-CoA + taurine <=> an N-fatty acyl-taurine + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59037", "l": "4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9017491", "l": "RHOJ GEFs activate RHOJ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25303", "l": "7,8-dihydroneopterin 3'-triphosphate + H2O => 7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19219", "l": "1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+) => 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17323", "l": "2-methyl-L-tryptophan + H(+) + S-adenosyl-L-homocysteine => L-tryptophan + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22612", "l": "(3S)-citramalyl-CoA = acetyl-CoA + pyruvate"}, {"i": "EC:4.1.3.25", "l": "\"(S)-citramalyl-CoA lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786101", "l": "IL4 binds IL4R:JAK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016308", "l": "1-phosphatidylinositol-4-phosphate 5-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61393", "l": "ATP + N(6)-(D-psicosyl)-L-lysyl-[protein] => ADP + H(+) + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16922", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018736", "l": "6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23618", "l": "alpha-santonin + H(+) + NADPH => 1,2-dihydro-alpha-santonin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33929", "l": "2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde => 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693250", "l": "RHOD binds effectors at the Golgi membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28970", "l": "L-proline(in) + Na(+)(in) <=> L-proline(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196773", "l": "COASY phosphorylates DP-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58478", "l": "a 1-acyl-sn-glycero-3-phosphocholine + CoA => an acyl-CoA + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2263444", "l": "Defective SGSH does not hydrolyse Heparan sulfate chain(7) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30406", "l": "Fe(3+)(out) + L-ascorbate(in) <=> Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66805", "l": "ferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + pisiferate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046180", "l": "KSPG is secreted from the cell (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20659", "l": "4-chlorophenylacetate + NH4(+) => 4-chlorophenylacetonitrile + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66541", "l": "A + cholesta-5,7-dien-3beta-ol + H2O => AH2 + cholesta-5,7-dien-3beta,25-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51988", "l": "(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O = 18S-resolvin E1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60644", "l": "3'-phosphoadenylyl sulfate + 3alpha-hydroxy-5alpha-androstan-17-one = 3alpha-sulfooxy-5alpha-androstan-17-one + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186786", "l": "Autophosphorylation of PDGF beta receptors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102585", "l": "cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside malonyltransferase activity"}, {"i": "MetaCyc:RXN-15331"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54061", "l": "(2E,6E)-farnesyl diphosphate + H2O => (2Z,6E)-hedycaryol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2428922", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23654", "l": "N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+) => N-terminal L-glutaminyl-[peptide]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51723", "l": "ATP(in) + CoA(in) + H(+)(out) + octadecanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + octadecanoyl-CoA(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36780", "l": "2-oxoglutarate + GDP-alpha-D-perosamine => GDP-4-dehydro-alpha-D-rhamnose + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200396", "l": "Creatine transport across the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50080", "l": "ATP + H2O + taurodeoxycholate(in) = ADP + H(+) + phosphate + taurodeoxycholate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12444", "l": "hexadecanal + NADP(+) = (2E)-hexadecenal + H(+) + NADPH"}, {"i": "EC:1.3.1.27", "l": "\"2-hexadecenal reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44534", "l": "1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614591", "l": "Excess cysteine yields lanthionine and H2S (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132133", "l": "C5b:C6:C7 inserts into the target cell membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009936", "l": "RNASEL cleaves cellular ssRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2855047", "l": "Hydrolysis of internal thioester in C4b (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24919", "l": "L-homoserine = 2-aminobut-2-enoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65371", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O <=> a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102424", "l": "sesaminol-2-O-gentiobioside 1,6-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-13821"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784462", "l": "TRIT1 transfers dimethylallyl group to adenosine-37 of tRNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9715357", "l": "crizotinib-resistant ALK mutants don't bind crizotinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102102", "l": "homocarnosine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247569", "l": "PADI4 deiminates Histones (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-744231", "l": "SLC35D2 exchanges UDP-sugars for UMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59928", "l": "erythritol + NADP(+) = D-erythrose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55635", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.98.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63022", "l": "(9Z,12Z)-octadecadienoate + NH4(+) => (9Z,12Z)-octadecadienamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396382", "l": "NOTCH1 Coactivator Complex binds promoters of HEY genes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700154", "l": "Active ALK binds SHC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29410", "l": "2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + NADPH + O2 <=> 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799466", "l": "TP53I3 dimerizes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52501", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => (13R)-hydroxy-(9Z,11E)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964280", "l": "Active Gq binds BTK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14002", "l": "choloyl-CoA + glycine => CoA + glycocholate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64138", "l": "(9Z)-octadecenoate + L-asparagine => H2O + N-(9Z-octadecenoyl)-L-asparagine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56989", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30983", "l": "H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] = beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209792", "l": "N-acetylation of serotonin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66329", "l": "taurine(out) => taurine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678843", "l": "ISGylation of protein translation regulator 4EHP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156930", "l": "GTP-binding activates eEF2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201457", "l": "BMP2 binds to the receptor complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59557", "l": "H2O + N,N'-diacetylchitobiono-1,5-lactone => H(+) + N,N'-diacetylchitobionate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602484", "l": "Activation of proMMP11 by FURIN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36185", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+) => a 1-O-alkyl-2-acetyl-sn-glycerol + CDP-choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17309", "l": "a phenyl acetate + H2O = a phenol + acetate + H(+)"}, {"i": "EC:3.1.1.2", "l": "\"Arylesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21670", "l": "ADP + H(+) + phosphate + sn-glycerol 3-phosphate(in) => ATP + H2O + sn-glycerol 3-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3601585", "l": "PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31758", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA + H2O <=> 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31375", "l": "H(+) + pyrrole-2-carboxylate = 1H-pyrrole + CO2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097163", "l": "sulfur carrier activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16600", "l": "ATP + NH4(+) + UTP <=> ADP + CTP + 2 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209151", "l": "miR-24 binds p16INK4A and p14ARF mRNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433374", "l": "Processing of SCF isoform 1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14615", "l": "ADP + H(+) + phosphate + taurine(in) => ATP + H2O + taurine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22862", "l": "deamido-NAD(+) + diphosphate => ATP + H(+) + nicotinate beta-D-ribonucleotide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031738", "l": "XCR1 chemokine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635868", "l": "ub-GLI is degraded by the proteasome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51403", "l": "octadecanoyl-CoA + serotonin <=> CoA + H(+) + N-octadecanoyl-serotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61613", "l": "2-oxoglutarate + 7-deoxycylindrospermopsin + O2 => 7-epi-cylindrospermopsin + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53762", "l": "allocholoyl-CoA + deoxycholate => allocholate + deoxycholoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25266", "l": "2-phenylethylamine + H2O + O2 => 2-phenylacetaldehyde + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-179410", "l": "Association of Nek2A with MCC:APC/C (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016691", "l": "chloride peroxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3858482", "l": "DVL is recruited to the receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17681", "l": "3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66502", "l": "alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => GDP-alpha-D-rhamnose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008054", "l": "IL1F10 binds IL1RAPL1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31894", "l": "2-hydroxy-1-phenyl-1-propanone + NADP(+) <=> 1-phenyl-1,2-propanedione + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25195", "l": "3-methylcatechol + H(+) + NADH => (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65085", "l": "asperaculane E + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => aculene D + CO2 + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55661", "l": "2 AH2 + all-trans-beta-carotene + 2 O2 => 2 A + echinenone + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15970", "l": "2 glutathione + H(+) + methylarsonate => glutathione disulfide + H2O + methylarsonous acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60963", "l": "18-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose <=> (9Z)-18-hydroxyoctadec-9-enoate 18-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19011", "l": "a carboxylate + H(+) + pyruvate => a 3-acylpyruvate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0016415", "l": "octanoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222462", "l": "SodB reduces superoxide to H2O2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71783", "l": "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15810", "l": "(2E)-geranyl diphosphate + H2O => (R)-linalool + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5082356", "l": "HSF1-mediated gene expression (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18975", "l": "4-O-deacetylvindoline + CO2 + succinate => 2-oxoglutarate + deacetoxyvindoline + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875816", "l": "STAT3 binds activated MET receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453358", "l": "poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18091", "l": "L-citrullyl-[protein] + NH4(+) => H2O + L-arginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64033", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP-beta-L-fucose => a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717396", "l": "SCN2A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030796", "l": "cycloartenol 24-C-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37713", "l": "1-O-(1Z)-alkenyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033506", "l": "TYSND1 cleaves AGPS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23910", "l": "2 [methionine synthase]-cob(II)alamin + NADPH + 2 S-adenosyl-L-methionine => 2 [methionine synthase]-methylcob(III)alamin + H(+) + NADP(+) + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14426", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49301", "l": "D-maltose(out) + N(pros)-phospho-L-histidyl-[protein] => alpha-maltose 6'-phosphate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49265", "l": "5-O-[(E)-caffeoyl]-shikimate + H2O => (E)-caffeate + H(+) + shikimate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56190", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53281", "l": "D-threose => D-erythrulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11559", "l": "(S)-carnitine + NAD(+) <=> 3-dehydrocarnitine + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29941", "l": "H(+)(out) + phosphate(out) => H(+)(in) + phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418925", "l": "ADORA2A,B bind Ade-Rib (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44623", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26422", "l": "3'-phosphoadenylyl sulfate + thyroxine = adenosine 3',5'-bisphosphate + H(+) + thyroxine sulfate"}, {"i": "EC:2.8.2.n2", "l": "\"Thyroxine sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913360", "l": "GM-CSF receptor alpha subunit binds GM-CSF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904493", "l": "tetrahydrofolyl-poly(glutamate) polymer binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53361", "l": "5,6-dihydrouridine(47) in tRNA + NADP(+) => H(+) + NADPH + uridine(47) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2995334", "l": "COX15 transforms heme O to heme A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9646468", "l": "mTORC1 binds RHEB:GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63152", "l": "an N-fatty acyl-taurine + H2O = a fatty acid + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672980", "l": "Dissociation of RAS:RAF complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62251", "l": "chloroacetaldehyde + H2O + NADP(+) <=> chloroacetate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41510", "l": "H2O + N(5)-hydroxy-L-ornithine + NADP(+) => L-ornithine + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13331", "l": "a 3-oxo-Delta(1)-steroid + AH2 => A + a 3-oxosteroid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-264865", "l": "Caspase-mediated cleavage of Lamin A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33549", "l": "H(+) + hexadecanoate + lanosterol => H2O + lanosteryl hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42715", "l": "S-adenosyl-L-methionine + uridine(54) in tRNA <=> 5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48033", "l": "(2S)-2-methylbutanoyl-CoA + FAD + H(+) => (2E)-2-methylbut-2-enoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72691", "l": "Formation of the 43S pre-initiation complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428917", "l": "G13 activation by TP receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50728", "l": "(Z)-(4-hydroxyphenyl)acetaldehyde oxime = 4-hydroxyphenylacetonitrile + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202129", "l": "HSP90 binds eNOS:Caveolin-1:CaM complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25308", "l": "7,8-dihydroneopterin 3'-phosphate + H2O => 7,8-dihydroneopterin + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799246", "l": "CHEK1 phosphorylates TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58227", "l": "L-glutamyl-[protein] + NAD(+) <=> 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45407", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate <=> 1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159005", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2186771", "l": "RNF111 binds SMAD7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050361", "l": "tryptophan 2-monooxygenase activity"}, {"i": "KEGG.REACTION:R00679"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5340124", "l": "CSN polymer binds CaPO4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40846", "l": "FAD + H(+) + octadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38264", "l": "(2R,3S)-beta-methylmalyl-CoA => 2-methylfumaryl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051064", "l": "TTP reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977371", "l": "Factor I inactivates Factor H-boundC3b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65547", "l": "ganglioside GM1 + H2O <=> an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-D-Glc"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9641111", "l": "Parkin transfers Ub to misfolded proteins (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51216", "l": "3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one = 3beta-sulfooxy-androst-5-en-17-one + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420883", "l": "Opsins act as GEFs for G alpha-t (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204364", "l": "ROBO1 binds SLIT2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29538", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445072", "l": "Interaction of PAK1 with Rac1-GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17446", "l": "H2 + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32219", "l": "all-trans-lycopene = gamma-carotene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18662", "l": "H2O + N(5)-[1(S)-1-carboxyethyl]-L-ornithine + NADP(+) => H(+) + L-ornithine + NADPH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18312", "l": "an N-acyl-D-amino acid + H2O <=> a carboxylate + a D-alpha-amino acid"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019162", "l": "pyridoxamine-oxaloacetate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54072", "l": "(2E)-geranyl diphosphate = beta-thujene + diphosphate"}, {"i": "EC:4.2.3.177", "l": "\"Beta-thujene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13422", "l": "an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate => an N-acylneuraminate 9-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59209", "l": "ATP + H(+) + octadecanoate => diphosphate + octadecanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160935", "l": "SMURF1 ubiquitinates RHOA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4088134", "l": "PLK1 phosphorylates FOXM1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102373", "l": "uvaol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26463", "l": "6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine => 3-methyl-6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55754", "l": "coenzyme M-coenzyme B heterodisulfide + 2 formate + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 CO2 + coenzyme B + coenzyme M + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-377644", "l": "Release of CSK from SRC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "67.889182750938758", "identifiers": [{"i": "GO:0019904", "l": "protein domain specific binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004168", "l": "dolichol kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22281", "l": "O-demethylpuromycin + S-adenosyl-L-methionine => H(+) + puromycin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805640", "l": "AKT phosphorylates KAT6A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2485111", "l": "Collagen type III degradation by MMP10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3785768", "l": "MRN complex binds DNA double strand breaks (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.21", "l": "\"Membrane-oligosaccharide glycerophosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31850", "l": "(S)-2,3-epoxysqualene <=> shionone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197963", "l": "DHFR2 reduces FOLA to DHF (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18610", "l": "carbamoyl phosphate + N(2)-acetyl-L-ornithine => H(+) + N(2)-acetyl-L-citrulline + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33685", "l": "3-oxoeicosasphinganine + CO2 + CoA => H(+) + L-serine + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17360", "l": "O2 + 2 R'C(R)SH <=> H2O2 + R'C(R)S-S(R)CR'"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17191", "l": "diphosphate + H(+) + N-adenylyl-L-phenylalanine => ATP + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029451", "l": "Activation of RAC1 by VAV (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6794346", "l": "NRXNs bind NLGNs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.1.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14299", "l": "an N-acylsphing-4-enine + D-galactose => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373707", "l": "Netrin-1 induced DCC clustering (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425861", "l": "Activation of Protein Kinase C novel isoforms (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62682", "l": "H(+) + H2O + norrubrofusarin => YWA1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43015", "l": "L-homocysteine <=> 2-aminobut-2-enoate + H(+) + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605723", "l": "Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29763", "l": "ATP + H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) = ADP + H(+) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005150", "l": "interleukin-1, type I receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58875", "l": "24-methylidenelophenol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46744", "l": "ATP + hydrogencarbonate = ADP + carboxyphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080078", "l": "tricaffeoyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58765", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphate + H(+) + NADPH => 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042972", "l": "licheninase activity"}, {"i": "MetaCyc:3.2.1.73-RXN"}, {"i": "EC:3.2.1.73", "l": "\"Licheninase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444523", "l": "CXCR5 binds CXCL13 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53960", "l": "4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + FMNH2 + O2 = 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + FMN + H(+) + H2O"}, {"i": "EC:1.14.14.13", "l": "\"4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48126", "l": "ganglioside GM3 (d18:1(4E)) + N-acetylneuraminate => ganglioside GD3 (d18:1(4E)) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57894", "l": "a quinol + 4 H(+)(out) + NADP(+) => a quinone + 5 H(+)(in) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66698", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + H(+) + S-adenosyl-L-homocysteine => (4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814764", "l": "Plasma membrane resorption (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47218", "l": "6beta-hydroxyestradiol-17beta + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53464", "l": "1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18570", "l": "an aromatic aldehyde + H2O + O2 => an aromatic carboxylate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047348", "l": "glycerol-3-phosphate cytidylyltransferase activity"}, {"i": "RHEA:13361", "l": "CTP + H(+) + sn-glycerol 3-phosphate = CDP-glycerol + diphosphate"}, {"i": "EC:2.7.7.39", "l": "\"Glycerol-3-phosphate cytidylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60300", "l": "N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27905", "l": "caffeine + H2O + ubiquinone-0 <=> 1,3,7-trimethylurate + ubiquinol-0"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070097", "l": "delta-catenin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199299", "l": "AKT phosphorylates FOXO transcription factors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483170", "l": "PS transports from the ER membrane to the IM membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60269", "l": "N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34252", "l": "1-deoxysphinganine + NADP(+) => 1-deoxy-3-dehydrosphinganine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9651467", "l": "SERPING1 variant does not bind kallikrein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21916", "l": "2 [Fe(III)cytochrome c550] + an aliphatic amine + H2O = 2 [Fe(II)cytochrome c550] + an aldehyde + 2 H(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "78.423603998002051", "identifiers": [{"i": "GO:0016783", "l": "sulfurtransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63182", "l": "H(+) + NADP(+) + 2 superoxide => NADPH + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25936", "l": "8-methylquinoline + A + H2O = 8-methylquinolin-2(1H)-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0023025", "l": "MHC class Ib protein complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48181", "l": "H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58344", "l": "beta-D-glucosyl-(1->3)-O-lithocholate + H2O = D-glucose + lithocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380272", "l": "Plk1-mediated phosphorylation of Nlp (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40161", "l": "NAD(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose => H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17655", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + diphosphate => (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "64.164273695218796", "identifiers": [{"i": "GO:0003677", "l": "DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52214", "l": "ethyl formate + H2O + N-(2-ethyl-6-methylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin] => acetochlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62742", "l": "1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2 => (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53069", "l": "4-methoxyestrone + UDP-alpha-D-glucuronate => 4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33677", "l": "H(+) + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADPH + O2 => H2O + N-(2,3-dihydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662619", "l": "MT1H binds zinc (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43583", "l": "A + D-arginine <=> AH2 + iminoarginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804762", "l": "TP53 forms homotetramers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5660665", "l": "Caspase-8 binds MALT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65541", "l": "ganglioside GM3 + H2O => an N-acyl-sphingoid base + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63417", "l": "2,6-dichlorohydroquinone + FADH2 + O2 => 2-chloro-6-hydroxy-1,4-benzoquinone + chloride + FAD + 2 H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047604", "l": "acetoin racemase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11927", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> globoside Gb3Cer (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29081", "l": "pyruvate + ubiquinol-8 => (R)-lactate + ubiquinone-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31295", "l": "(2E)-2-hydroxypenta-2,4-dienoate = 2-oxopent-4-enoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28720", "l": "adenine(in) + H(+)(in) => adenine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1296045", "l": "Activation of Potassium transport channels (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27487", "l": "(S)-2-ureidoglycine + CO2 + NH4(+) => allantoate + 2 H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19393", "l": "L-lysine + pyruvate = (S)-2-amino-6-oxohexanoate + L-alanine"}, {"i": "EC:2.6.1.71", "l": "\"Lysine--pyruvate 6-transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55895", "l": "a 2-all-trans-polyprenylphenol + H(+) + NADPH + O2 <=> a 3-(all-trans-polyprenyl)benzene-1,2-diol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38252", "l": "hexadecan-1-ol + octadecanoyl-CoA => CoA + hexadecanyl octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228940", "l": "Transcytosis and dissociation of botB:NTNHA:HA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.7.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52475", "l": "16alpha,17beta-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047629", "l": "ADP deaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20204", "l": "ATP + H2O + L-phenylalanine <=> AMP + D-phenylalanine + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48794", "l": "alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+) => GDP-beta-L-fucose + Lc4Cer"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51630", "l": "CO2 + dUTP + H2O => formate + H(+) + UTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5679205", "l": "ULK1 phosphorylates Beclin-1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36872", "l": "(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617927", "l": "FOXO4 binds ATXN3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848726", "l": "PTK6 phosphorylates BCAR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936667", "l": "sulfate binds to SubI outside the membrane (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25428", "l": "ATP + N-acetyl-D-hexosamine = ADP + H(+) + N-acetyl-alpha-D-hexosamine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683888", "l": "LMCD1 binds GATA6, sequestering it (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9679028", "l": "JAK3 binds JAK3 inhibitors (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696491", "l": "CNTF binds CNTFR complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47141", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354124", "l": "Phosphorylation of pPTK2 by SRC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40532", "l": "2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + neopikromycin + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41369", "l": "1-O-tetradecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14760", "l": "2 [Fe(III)cytochrome c] + L-galactono-1,4-lactone <=> 2 [Fe(II)cytochrome c] + 3 H(+) + L-ascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607757", "l": "K63polyUb-TRAF6 ubiquitinates TAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936007", "l": "CLDN5 (Claudin-5) gene expression is stimulated by RUNX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39420", "l": "3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25076", "l": "(9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626953", "l": "TNF-alpha:TNFR1 binds DENN/MADD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.8.-", "l": "\"With a flavin as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706364", "l": "Internalization of ubiquitinated FLT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13148", "l": "4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate <=> alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28506", "l": "alpha-Kdo-(2->6)-lipid IVA + ATP = 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP + H(+)"}, {"i": "EC:2.7.1.166", "l": "\"3-deoxy-D-manno-octulosonic acid kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11507", "l": "6-demethylsterigmatocystin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + sterigmatocystin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193646", "l": "NGF binding to p75NTR inactivates RHOA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45359", "l": "H2O + N-(11Z-eicosenoyl)-sphing-4-enine <=> (11Z)-eicosenoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49498", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane => 2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3785711", "l": "Telomere shortening during replicative exhaustion (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42563", "l": "uridine(27/28) in mitochondrial tRNA <=> pseudouridine(27/28) in mitochondrial tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210282", "l": "Interaction of GPVI and FceRI gamma (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034023", "l": "5-(carboxyamino)imidazole ribonucleotide mutase activity"}, {"i": "RHEA:13193", "l": "5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate"}, {"i": "EC:5.4.99.18", "l": "\"5-(carboxyamino)imidazole ribonucleotide mutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53289", "l": "3-dehydro-scyllo-inosose + H2O => 5-dehydro-L-gluconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38075", "l": "2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56718", "l": "H(+) + S-disulfanyl-L-cysteinyl-[SoxY protein] + sulfate => H2O + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033971", "l": "hydroxyisourate hydrolase activity"}, {"i": "KEGG.REACTION:R06601"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211951", "l": "CYP1B1 4-hydroxylates EST17b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008239", "l": "dipeptidyl-peptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031518", "l": "NR1H2,3 binds the APOC1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74258", "l": "XDH oxidizes xanthine to form urate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58399", "l": "4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + 5 H(+) + O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NH4(+) + 4 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19458", "l": "2-nitrophenol + 2 H(+) + 2 NADPH + O2 => catechol + H2O + 2 NADP(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36296", "l": "alpha-maltose 6'-phosphate + H2O => D-maltose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16149", "l": "beta-nicotinamide D-ribonucleotide + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide"}, {"i": "EC:2.4.2.12", "l": "\"Nicotinamide phosphoribosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44994", "l": "CoA + O-2-methylbutanoyl-(R)-carnitine => (R)-carnitine + 2-methylbutanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36097", "l": "methyl salicylate + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + salicylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.69", "l": "\"Biflaviolin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18597", "l": "H(+) + NAD(+) + 2 reduced [rubredoxin] = NADH + 2 oxidized [rubredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016688", "l": "L-ascorbate peroxidase activity"}, {"i": "MetaCyc:L-ASCORBATE-PEROXIDASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-870538", "l": "TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58750", "l": "H(+) + nectriapyrone + S-adenosyl-L-homocysteine => desmethylnectriapyrone + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000263", "l": "TCII:Cbl is degraded to release Cbl (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23214", "l": "acetate + beta-alanine => H2O + N-acetyl-beta-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114254", "l": "CYCS binds to APAF1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158340", "l": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799199", "l": "COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41176", "l": "[Co(I) dimethylamine-specific corrinoid protein] + dimethylamine + H(+) => [methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663105", "l": "p-BMAL1:p-CLOCK,NPAS2 binds BHLHE41 (DEC2) gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11586", "l": "D-ornithine => L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928640", "l": "PAKs phosphorylate MLC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497855", "l": "Ascorbate can reduce the BH3 radical back to BH4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868118", "l": "MAPK12 phosphorylates PTPN3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1449687", "l": "Corticosteroids bind to CBG in blood (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047488", "l": "heparin lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36495", "l": "alpha-D-glucose + ATP = ADP + alpha-D-glucose 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52066", "l": "(9Z)-octadecenoate + 13-hydroxy-octadecanoate + H(+) => 13-(9Z-octadecenoyloxy)-octadecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031712", "l": "B1 bradykinin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193665", "l": "MYD88 dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64332", "l": "ATP + CoA + nicotinate = AMP + diphosphate + nicotinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52740", "l": "glyphosate + H2O + O2 = aminomethylphosphonate + glyoxylate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40844", "l": "FAD + H(+) + octadecanoyl-CoA => (2E)-octadecenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879358", "l": "AGER-1,2,3 bind AGEs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-947535", "l": "Cyclisation of GTP to precursor Z (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60203", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13717", "l": "2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH"}, {"i": "EC:1.1.1.267", "l": "\"1-deoxy-D-xylulose-5-phosphate reductoisomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62866", "l": "9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + S-adenosyl-L-homocysteine => 7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29127", "l": "a menaquinol + nitrate = a menaquinone + H2O + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174119", "l": "Free APC/C phosphorylated by Plk1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050546", "l": "4-hydroxyphenylpyruvate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21354", "l": "(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+) => 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40747", "l": "2-oxoglutarate + L-lysine + O2 = (3S)-3-hydroxy-L-lysine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65111", "l": "aculene C + L-prolyl-[peptidyl-carrier protein] <=> aculene A + holo-[peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-378952", "l": "Thyrotropin is a heterodimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45383", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + (5Z,8Z,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28401", "l": "H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate <=> L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3772430", "l": "CTNNBIP1 binds beta-catenin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264834", "l": "Endocytosis and degradation of apoA-I (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018670", "l": "4-aminobenzoate 1-monooxygenase activity"}, {"i": "EC:1.14.13.27", "l": "\"4-aminobenzoate 1-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174446", "l": "Removal of remaining Flap from the C-strand (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24338", "l": "AMP + an acyl-CoA + diphosphate => a carboxylate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65061", "l": "NADP(+) + taurochenodeoxycholate => 7-oxotaurolithocholate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32786", "l": "ATP + glycine betaine(out) + H2O <=> ADP + glycine betaine(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624798", "l": "LBR binds KPNB1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10495", "l": "H2O + phosphocholine <=> choline + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686524", "l": "PP6-PPP6R3 dephosphorylates TERF2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18776", "l": "[methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M <=> [Co(I) methylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29426", "l": "ATP + diphosphate <=> ADP + H(+) + triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139918", "l": "Phosphorylation of BIM by JNK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625426", "l": "Retrograde IFT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193776", "l": "Efflux of 24-hydroxycholesterol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59467", "l": "NADP(+) + octadecan-1-ol <=> H(+) + NADPH + octadecanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.36", "l": "\"sn-1 acyl-lipid omega-3 desaturase (ferredoxin)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62357", "l": "8-oxo-GDP + H2O => 8-oxo-GMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-606287", "l": "RSF complex binds the centromere (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55589", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-sphingoid base => a 1,2-diacyl-sn-glycerol + an inositol-1-phosphoceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32980", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O => a fatty acid + H(+) + sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54954", "l": "AMP + diphosphate + nonanoyl-CoA => ATP + CoA + nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60191", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034826", "l": "1,2-dihydroxy-1,2,5,6,7,8-hexyhadronaphthalene dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419197", "l": "Myosin regulatory light chain phosphorylation by ROCK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050176", "l": "phenylalanine N-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49628", "l": "acetyl-CoA + 3 malonyl-CoA + 2 S-adenosyl-L-methionine = 3,5-dimethylorsellinate + 3 CO2 + 4 CoA + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57997", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose => (20S)-ginsenoside Rh2 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3222128", "l": "NOC2L binds TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050295", "l": "steryl-beta-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55314", "l": "1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45014", "l": "(4R)-hydroxysphinganine + octadecanoate => H2O + N-octadecanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202168", "l": "Phosphorylation of ZAP-70 by Lck (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2288097", "l": "Condensin II complex binds H4K20me1-containing nucleosomes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18066", "l": "ATP + H2O + phosphonate(out) => ADP + H(+) + phosphate + phosphonate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55735", "l": "19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47544", "l": "trans-4-hydroxy-L-proline betaine = cis-4-hydroxy-D-proline betaine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166817", "l": "Cleavage of C3 by C3 convertases (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050631", "l": "corydaline synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30204", "l": "H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate => 2 GDP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60718", "l": "(1R,3R)-chrysanthemate + 2 H(+) + NADPH => (1R,3R)-chrysanthemal + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19744", "l": "formyl-CoA + H2O <=> CoA + formate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247497", "l": "ERBB3 binds neuregulins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798743", "l": "Exocytosis of secretory granule membrane proteins (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65138", "l": "1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47143", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-354173", "l": "Activation of Rap1 by cytosolic GEFs (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45874", "l": "4-hydroxy-6-(14-hydroxytetradecyl)-pyran-2-one + 2 CO2 + 3 CoA => 15-hydroxypentadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3903017", "l": "SUMOylation of PPARGC1A with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58629", "l": "FADH2-C4alpha-hydroperoxide + H(+) + NADPH + rifamycin SV => FADH2 + H2O + NADP(+) + rifamycin SV hemiaminal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49737", "l": "2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate => CO2 + deoxyviolacein + 2 H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29659", "l": "O-acetyl-L-serine(in) = O-acetyl-L-serine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429157", "l": "ABCC4 accumulation of dense granule contents (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663271", "l": "NR1D1 (REV-ERBA) binds heme, the CLOCK gene, and recruits corepressors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0005017", "l": "platelet-derived growth factor-activated receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656438", "l": "Defective ALDOB does not cleave Fru 1-P to GA and DHAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20078", "l": "guanosine(18) in tRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985950", "l": "p-Y649-STAT5A, p-STAT5B dimerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0005003", "l": "ephrin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247569", "l": "PADI4 deiminates Histones (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785181", "l": "LMF1,2 bind LIPC dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "68.3621111081913", "identifiers": [{"i": "GO:0015171", "l": "amino acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25161", "l": "2-oxoglutarate + L-ornithine => L-glutamate + L-glutamate 5-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015430", "l": "ABC-type glycerol-3-phosphate transporter activity"}, {"i": "MetaCyc:3.6.3.20-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73718", "l": "UBF-1 Binds rDNA Promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54234", "l": "1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-dioctanoyl-sn-glycerol + CDP-choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56050", "l": "daidzein 7-O-beta-D-glucoside + UDP => daidzein + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23926", "l": "2',3'-cGAMP + diphosphate => pppGp(2'-5')A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665989", "l": "DIAPH1 binds RHOA:GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24482", "l": "a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol => a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050152", "l": "omega-amidase activity"}, {"i": "RHEA:11716", "l": "a monoamide of a dicarboxylate + H2O = a dicarboxylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114671", "l": "vWF binds to collagen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043798", "l": "glycerate 2-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32611", "l": "(6E)-8-hydroxygeranial + NADP(+) = (6E)-8-oxogeranial + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809680", "l": "MTMR12 binds MTM1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26107", "l": "cis-homoaconitate + H2O => homocitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50614", "l": "(2E)-decenal + H(+) + NADPH => decanal + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871376", "l": "p-Y281,292-RUFY1 binds PI3P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51476", "l": "a ribonucleoside 5'-triphosphate + formate + H(+) = a 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O"}, {"i": "EC:1.1.98.6", "l": "\"Ribonucleoside-triphosphate reductase (formate)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54298", "l": "diphosphate + O-(5'-guanylyl)-L-tyrosyl-[protein] => GTP + L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604712", "l": "Initial activation of proMMP7 by trypsin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47384", "l": "4-acetoxyphenol + H2O = acetate + H(+) + hydroquinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11771", "l": "diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate <=> 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49150", "l": "dTDP-alpha-D-forosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine => dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606345", "l": "Recruitment of IRF3 to activated ZBP1:TBK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50219", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> (8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0031369", "l": "translation initiation factor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985950", "l": "p-Y649-STAT5A, p-STAT5B dimerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033509", "l": "USP9X binds Ub:PEX5L (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31967", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] = ent-11beta-hydroxycassa-12,15-diene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.112", "l": "\"Ent-cassa-12,15-diene 11-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674022", "l": "BRAP autoubiquitinates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174931", "l": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24544", "l": "H2O + L-lysyl-[protein] + O2 = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+)"}, {"i": "EC:1.4.3.13", "l": "\"Protein-lysine 6-oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30189", "l": "a quinol + orotate => (S)-dihydroorotate + a quinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61527", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> (15S)-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694428", "l": "LMAN family proteins bind glycosylated cargo (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22036", "l": "[phosphate](n) + D-glucose = [phosphate](n-1) + D-glucose 6-phosphate + H(+)"}, {"i": "EC:2.7.1.63", "l": "\"Polyphosphate--glucose phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13091", "l": "6 [Fe(II)cytochrome c] + 8 H(+) + nitrite => 6 [Fe(III)cytochrome c] + 2 H2O + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10108", "l": "(7S)-salutaridinol + NADP(+) = H(+) + NADPH + salutaridine"}, {"i": "EC:1.1.1.248", "l": "\"Salutaridine reductase (NADPH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705320", "l": "TBK1, IKBKE are autophosphorylated at Ser172 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38489", "l": "(9Z)-octadecenoate + glycerol + H(+) => 1-(9Z-octadecenoyl)-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551683", "l": "SUMOylation of TOPORS with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5679239", "l": "ULK complex translocates to the ER (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27605", "l": "(2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate <=> di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18219", "l": "an omega-aminoaldehyde + L-glutamate => 2-oxoglutarate + an alkane-alpha,omega-diamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41521", "l": "menaquinone-4 + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + omega-hydroxymenaquinone-4 + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449117", "l": "TXLNA (IL14) binds syntaxin1A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16112", "l": "ATP + beta-D-fructose 6-phosphate <=> ADP + beta-D-fructose 1,6-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018814", "l": "RHOT1 hydrolyzes GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56950", "l": "H(+) + phosphoenolpyruvate + UDP => pyruvate + UTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17677", "l": "2-(acetamidomethylene)-3-(hydroxymethyl)succinate + H(+) + 2 H2O = 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4(+)"}, {"i": "EC:3.5.1.66", "l": "\"2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35274", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38425", "l": "(9Z)-octadecenoate + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H(+) => 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604752", "l": "Initial activation of proMMP13 by MMP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3149519", "l": "MMACHC decyanates CNCbl (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070975", "l": "FHA domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51030", "l": "7-chloroindole-3-pyruvate imine dimer + 2 H2O => 2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50929", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 => (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080098", "l": "L-tyrosine:pyruvate aminotransferase activity"}, {"i": "MetaCyc:RXN3O-4157"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003943", "l": "N-acetylgalactosamine-4-sulfatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53011", "l": "(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate <=> di-trans,poly-cis-polyprenyl diphosphate + n diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.19"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990829", "l": "C-rich single-stranded DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373716", "l": "DCC interacting NCK-1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034831", "l": "(R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653850", "l": "Defective SLC36A2 does not cotransport Gly, L-Pro with H+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3149492", "l": "cob(II)alamin dissociates from MMACHC:MMADHC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28523", "l": "D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O => D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19035", "l": "an N-acyl-D-mannosamine => an N-acyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21634", "l": "2 1,2-benzoquinone + 2 H2O => 2 catechol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50590", "l": "15-oxoprostaglandin F2alpha + H(+) + NADPH => 13,14-dihydro-15-oxo-PGF2alpha + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28003", "l": "beta-D-fructose 6-phosphate => D-glyceraldehyde 3-phosphate + dihydroxyacetone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47651", "l": "D-ribitol 5-phosphate + H2O <=> phosphate + ribitol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607023", "l": "factor IXa associates with cell membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36482", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA <=> (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941895", "l": "Formation of CDK4/6:CCND complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237160", "l": "MTA is cleaved and phosphorylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30311", "l": "7-methylxanthine + H(+) + NADH + O2 = formaldehyde + H2O + NAD(+) + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672951", "l": "Inactive RAFs bind YWHAB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678843", "l": "ISGylation of protein translation regulator 4EHP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015346", "l": "ferric triacetylfusarinine C:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983153", "l": "E1 mediated ubiquitin activation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11369", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H(+) + NADH + O2 => 1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51635", "l": "all-trans-(4S)-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-(4S,16)-dihydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043810", "l": "ornithine-acyl [acyl carrier protein] N-acyltransferase activity"}, {"i": "RHEA:20633", "l": "a (3R)-hydroxyacyl-[ACP] + L-ornithine = a lyso-ornithine lipid + H(+) + holo-[ACP]"}, {"i": "EC:2.3.2.30", "l": "\"L-ornithine N(alpha)-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203977", "l": "SAR1 Activation And Membrane Binding (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685318", "l": "BCDX2 complex formation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-482772", "l": "Release of platelet cytosolic components (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44679", "l": "a triacyl-sn-glycerol + all-trans-retinol <=> a diacylglycerol + an all-trans-retinyl ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55260", "l": "2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15368", "l": "3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + UDP-alpha-D-xylose <=> 3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29025", "l": "H(+)(out) + L-fucose(out) => H(+)(in) + L-fucose(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112604", "l": "Phosphorylated STATs are released (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56549", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74726", "l": "Dissociation of insulin from insulin receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035198", "l": "miRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11850", "l": "[thioredoxin]-dithiol + glycine betaine + H(+) + phosphate => [thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62542", "l": "2 [Fe(III)cytochrome c] + dihydroouabain => 2 [Fe(II)cytochrome c] + 3 H(+) + ouabain"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247960", "l": "Activation of p38 MAPK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683774", "l": "p-T68-CHEK2 dimerizes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10132", "l": "ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate"}, {"i": "EC:6.2.1.25", "l": "\"Benzoate--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209566", "l": "TRAF6 is auto-ubiquitinated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10519", "l": "(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) <=> (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57816", "l": "dGMP + H2O = 2-deoxy-D-ribose 5-phosphate + guanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34810", "l": "(R)-dihydrocamalexate + O2 + reduced [NADPH--hemoprotein reductase] <=> camalexin + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59094", "l": "[(1->3)-alpha-D-glucosyl](n+1) + D-fructose => [(1->3)-alpha-D-glucosyl](n) + sucrose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2243938", "l": "AKT1 E17K mutant is phosphorylated by TORC2 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42298", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + holo-[ACP] => a 1-acyl-sn-glycero-3-phosphate + a fatty acyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-947499", "l": "Exchange of oxygen with sulfur in MoCo (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952081", "l": "RUNX proteins bind the p14-ARF promoter at the CDKN2A locus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45700", "l": "glycine betaine + H2O + O2 = formaldehyde + H2O2 + N,N-dimethylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192123", "l": "CYP27A1 27-hydroxylates CHOL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005367", "l": "myo-inositol:sodium symporter activity"}, {"i": "REACT:R-HSA-429663", "l": "SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9659782", "l": "Defective RB1 does not bind E2F1,(E2F2,E2F3) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50980", "l": "prostaglandin E1(out) = prostaglandin E1(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705466", "l": "p-Y-STAT1,3,5 dimer enhances expression of SOCS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218847", "l": "PAK2 binds NCK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29627", "l": "alpha-maltohexaose + beta-maltose = alpha-maltoheptaose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399969", "l": "AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197697", "l": "Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65702", "l": "cholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45640", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17124", "l": "carbamoyl phosphate + L-lysine <=> H(+) + L-homocitrulline + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682011", "l": "LC3 binds ATG7 dimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5660665", "l": "Caspase-8 binds MALT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54011", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21047", "l": "24-methylidenelophenol + S-adenosyl-L-methionine <=> (Z)-24-ethylidenelophenol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5159250", "l": "ATF7IP binds SETDB1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32423", "l": "(1R,4R)-dihydrocarvone + A = (R)-carvone + AH2"}, {"i": "RHEA:32427", "l": "(1R,4S)-isodihydrocarvone + A = (S)-carvone + AH2"}, {"i": "EC:1.3.99.25", "l": "\"Carvone reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2250301", "l": "Formation of lysyl-pyrrole cross-links (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23432", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.52", "l": "\"(S)-limonene 7-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975040", "l": "KRAB-ZNF / KAP Interaction (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62076", "l": "D-galactose 6-phosphate + NAD(+) = 6-phospho-D-galactono-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59608", "l": "beta-alanyl-L-lysine + H2O = beta-alanine + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56090", "l": "CMP + globoside DSGG + H(+) => CMP-N-acetyl-beta-neuraminate + globoside MSGG"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58296", "l": "25-substituted-cholesterol + beta-D-glucosyl-N-hexadecanoylsphing-4E-enine = 25-substituted-cholesteryl beta-D-glucoside + N-hexadecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395992", "l": "p-T,4S-IRF3 is dimerized (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22006", "l": "ADP + H(+) + O-phospho-L-seryl-[myosin light chain] => ATP + L-seryl-[myosin light chain]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.3.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28760", "l": "beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose => alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22577", "l": "an N-acyl-L-homoserine lactone + H2O => an N-acyl-L-homoserine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20752", "l": "A + 2 cob(II)alamin + 2 H(+) + 2 H2O = AH2 + 2 aquacob(III)alamin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64209", "l": "an N-(fatty acyl)-L-glutamine + H2O => a fatty acid + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217209", "l": "Generation of a DNA double strand break (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51626", "l": "CO2 + dGTP + H2O => formate + GTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683888", "l": "LMCD1 binds GATA6, sequestering it (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31522", "l": "O2 + torulene <=> 3-methyl-2-butenal + 4'-apo-beta-carotenal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944227", "l": "Association of procollagen type XXII (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982017", "l": "Active G alpha (q) binds RGS proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3240957", "l": "Formation of PRC2-EZH2 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63456", "l": "(2E,6E,10E)-geranylgeraniol + CTP = (2E,6E,10E)-geranylgeranyl phosphate + CDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51245", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36258", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2 <=> (6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54852", "l": "H(+) + heptan-4-one + NADPH + O2 = H2O + NADP(+) + propyl butanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.22"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683593", "l": "ATG7:ATG3:LC3 dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11626", "l": "acetone oxime + pyruvate => 2-(hydroxyimino)propanoate + acetone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54332", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786190", "l": "CMBL hydrolyses OM to OLMS (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382053", "l": "Translocation of PDGF from ER to Golgi (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28143", "l": "H2O + streptothricin D => streptothricin D acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602454", "l": "proMMP9 binds TIMP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22806", "l": "(6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH => (6S,9R)-vomifoliol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0005167", "l": "neurotrophin TRK receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67151", "l": "L-arginine + L-cysteinyl-[NO transferase protein] + NADPH + 2 O2 <=> 2 H2O + L-citrulline + NADP(+) + S-nitroso-L-cysteinyl-[NO transferase protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432712", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418858", "l": "RhoGTPase GEF's recruited to DCC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-354077", "l": "Integrin alphaIIb beta3 activation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74723", "l": "Endosome acidification (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66595", "l": "(DNA)-(deoxyribonucleoside 5'-phosphate)-(deoxyribose 5'-phosphate)-(deoxyribonucleoside 5'-phosphate) <=> (DNA)-3'-(deoxyribonucleoside 5'-phosphate)-(2,3-dehydro-2,3-deoxyribose 5'-phosphate) + H(+) + phospho-5'-(DNA)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607023", "l": "factor IXa associates with cell membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603797", "l": "PEX19:PEX3 binds PEX16 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33249", "l": "1-pyrroline + H2O2 + NH4(+) => O2 + putrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168046", "l": "Collagen type XII degradation by MMP12 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57578", "l": "H(+) + H2O + loganate + oxidized [NADPH--hemoprotein reductase] => 7-deoxyloganate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2106615", "l": "Removal of siRNA passenger strand (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47306", "l": "(2E,9Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (9Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.27"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17926", "l": "L-arabinofuranose + NAD(+) => H(+) + L-arabinono-1,4-lactone + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989753", "l": "Expression of PEX11A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0097157", "l": "pre-mRNA intronic binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42915", "l": "cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018010", "l": "glycoprotein N-palmitoyltransferase activity"}, {"i": "MetaCyc:GLYCOPROTEIN-N-PALMITOYLTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51508", "l": "2-oxoglutarate + L-proline + O2 = CO2 + succinate + trans-4-hydroxy-L-proline"}, {"i": "EC:1.14.11.57", "l": "\"L-proline trans-4-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399711", "l": "Activation of Ca impermeable AMPA receptors (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23725", "l": "H2O + O2 + pyridoxal => 4-pyridoxate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46879", "l": "[(1->4)-beta-D-mannuronosyl](n) + GDP-alpha-D-mannuronate <=> [(1->4)-beta-D-mannuronosyl](n+1) + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24377", "l": "apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin => AMP + diphosphate + H(+) + holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60241", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57825", "l": "dAMP + H2O => 2-deoxy-D-ribose 5-phosphate + adenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44696", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77612", "l": "Formation of dsRNA structure by looping  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36962", "l": "D-ribono-1,4-lactone + H(+) + NADH <=> D-ribose + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36664", "l": "(S)-1-pyrroline-5-carboxylate + H(+) + H2O + malonyl-CoA => (2S,5S)-5-carboxymethylproline + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426209", "l": "DAG activation of TRPC channels (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43176", "l": "cytidine(2870) in 25S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(2870) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.310", "l": "\"25S rRNA (cytosine(2870)-C(5))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40862", "l": "(9Z)-hexadecenoyl-CoA + FAD + H(+) <=> (2E,9Z)-hexadecadienoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.375", "l": "\"L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40000", "l": "a sphingoid 1-phosphate => a fatty aldehyde + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665410", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004493", "l": "methylmalonyl-CoA epimerase activity"}, {"i": "RHEA:20553", "l": "(R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA"}, {"i": "EC:5.1.99.1", "l": "\"Methylmalonyl-CoA epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43413", "l": "a D-galactosylceramide + H2O => an N-acyl-sphingoid base + D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62423", "l": "a (R)-2-hydroxy fatty acid + O2 <=> a fatty acid + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56955", "l": "CTP + pyruvate <=> CDP + H(+) + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46342", "l": "ADP + H(+) + N-(hexadecanoyl)-sphing-4-enine-1-phosphate => ATP + N-hexadecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35484", "l": "5alpha-cholest-7-en-3-one + S-adenosyl-L-methionine => 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11029", "l": "ATP + D-mannose => ADP + D-mannose 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35543", "l": "3-phosphooxypyruvate + H2O = 3-hydroxypyruvate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21274", "l": "ADP + glutathionylspermidine + H(+) + phosphate => ATP + glutathione + spermidine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035473", "l": "lipase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110360", "l": "Recruitment of POLB to the AP site (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390929", "l": "HTR1 and 5A receptors can bind serotonin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27504", "l": "3',5'-di-O-methyltricetin + S-adenosyl-L-methionine <=> 3',4',5'-O-trimethyltricetin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004563", "l": "beta-N-acetylhexosaminidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45762", "l": "dTDP + H(+) + rhodomycin D => dTDP-beta-L-daunosamine + epsilon-rhodomycinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52879", "l": "16beta,17beta-estriol + UDP-alpha-D-glucuronate <=> 16beta,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016463", "l": "P-type zinc transporter activity"}, {"i": "RHEA:20621", "l": "ATP + H2O + Zn(2+)(in) = ADP + H(+) + phosphate + Zn(2+)(out)"}, {"i": "EC:7.2.2.12", "l": "\"P-type Zn(2+) transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111915", "l": "CAMK4 autophosphorylates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38870", "l": "uridine(516) in 16S rRNA <=> pseudouridine(516) in 16S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56006", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34904", "l": "4 glutathione + 2 H(+) + selenite => glutathione disulfide + 3 H2O + selenodiglutathione"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904399", "l": "heparan sulfate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55504", "l": "(5S,9S,10S)-drim-7-en-11-ol + O2 + reduced [NADPH--hemoprotein reductase] = (5S,10S)-(9R)-7-drimene-11,12-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.72", "l": "\"Drimenol monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018768", "l": "RHOU auto-activates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51511", "l": "2-oxoglutarate + L-proline + O2 <=> CO2 + succinate + trans-4-hydroxy-L-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905057", "l": "voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41571", "l": "aclacinomycin T + dTDP-2-deoxy-beta-L-fucose <=> aclacinomycin S + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9619756", "l": "NR1H2 binds ABCA1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13707", "l": "alpha-D-Man-(1->3)-[alpha-D-GlcNAc-(1->2)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + H(+) + UDP => alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373722", "l": "Nephrin binds CASK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928591", "l": "EPH:EFN tetramers oligomerise (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14455", "l": "(2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) + NADH => 4-(phosphooxy)-L-threonine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809707", "l": "MTMR12 binds MTMR2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54158", "l": "[ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21767", "l": "heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47575", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1b (d18:1(4E)) <=> CMP + ganglioside GT1b (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199298", "l": "AKT phosphorylates CREB1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59197", "l": "holo-[(phenol)carboxyphthiodiolenone synthase] + icosanoyl-AMP => AMP + H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40991", "l": "(E)-4-coumaroyl-CoA + H2O = 3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50421", "l": "L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein] => H(+) + N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689085", "l": "ATXN3 binds polyUb-PARK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851919", "l": "Activated MET binds GAB1 and GRB2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11974", "l": "12 H(+) + 4 iron(III) oxide-hydroxide => 4 Fe(2+) + 6 H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448744", "l": "IL20RA binds IL20RB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23937", "l": "D-gluconate + NADP(+) => 5-dehydro-D-gluconate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63087", "l": "chloride + FADH2 + ilicicolin B + O2 <=> FAD + H(+) + 2 H2O + ilicicolin A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202328", "l": "Translocation of PKC theta to plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46321", "l": "3beta-hydroxy-chol-5-ene-24-oyl-CoA + A => 3beta-hydroxy-chol-5,22-dien-24-oyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855186", "l": "I(1,3,4,5)P4 transports from the cytosol to the ER lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55129", "l": "(3R)-hydroxy-5-methylhexanoyl-[ACP] => (2E)-5-methylhexenoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-868657", "l": "Glucanotrehalose is hydrolyzed to 1,4-alpha-glucan and trehalose (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353475", "l": "Association of the XRCC4:DNA ligase IV complex with the DNA-PK:DNA synaptic complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56913", "l": "(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + H2O + NAD(+) => (E)-2-((N-methylformamido) methylene)succinate + 3 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45506", "l": "(2R,3E)-phycoerythrobilin + apo-[C-phycoerythrin alpha-subunit] => [C-phycoerythrin alpha-subunit]-Cys(84)-phycoerythrobilin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40998", "l": "3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA <=> 4-hydroxybenzaldehyde + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11475", "l": "an N-methyl-L-amino acid + H2O + O2 <=> an L-alpha-amino acid + formaldehyde + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57125", "l": "2-oxoglutaramate => 2-hydroxy-5-oxoproline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61924", "l": "(2S,4R)-ketoconazole(in) + ATP + H2O = (2S,4R)-ketoconazole(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660824", "l": "ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389756", "l": "AKT interacts and phosphorylates Cot (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606789", "l": "ARSB hydrolyses DS (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432909", "l": "Interaction of Plectin with Integrin beta 4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33299", "l": "[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine"}, {"i": "EC:2.5.1.46", "l": "\"Deoxyhypusine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51065", "l": "3'-phosphoadenylyl sulfate + lithocholate => adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31980", "l": "NADPH + O2 + trimethylamine => H2O + NADP(+) + trimethylamine N-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.20"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34592", "l": "Co-precorrin-7 + S-adenosyl-L-methionine => Co-precorrin-8X + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41437", "l": "(9Z)-octadecenoyl-CoA + cholesterol => cholesteryl (9Z-octadecenoate) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23037", "l": "2 inosine + O2 => 2 5'-dehydroinosine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34069", "l": "diphosphate + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose 5-phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + trans,octa-cis-decaprenyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11861", "l": "ATP + L-histidyl-[protein] => ADP + H(+) + N(tele)-phospho-L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43155", "l": "adenosine(58) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31675", "l": "NADP(+) + raucaffrinoline = H(+) + NADPH + perakine"}, {"i": "EC:1.1.1.317", "l": "\"Perakine reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804998", "l": "p14ARF forms a ternary complex with MDM2 and TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036401", "l": "pyrokinin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236970", "l": "Proteasomal clevage of exogenous antigen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31320", "l": "(2R)-3-phosphoglycerate + UDP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445076", "l": "Phosphorylation of Y1229 in L1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782443", "l": "QTRT1:QTRTD1 exchange guanine for queuosine at guanosine-34 of tRNA(Tyr) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201634", "l": "Caspase-mediated cleavage of FADK 1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5339711", "l": "misspliced mutants of LRP5 support enhanced beta-catenin-dependent signaling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432148", "l": "Fgr may phosphorylate p38 MAPK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390663", "l": "ADRA2A,B,C bind ADR,NAd (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44167", "l": "ATP + H2O <=> adenine + D-ribose 5-triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45979", "l": "3-oxochola-1,4-dien-22-oate + H(+) + NADH + O2 <=> 9alpha-hydroxy-3-oxochola-1,4-dien-22-oate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.51", "l": "\"4-hydroxyphenylalkanoate adenylyltransferase FadD29\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2530429", "l": "Formation of soluble VTN:C5b-C9  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218906", "l": "RIPK3 phosphorylates MLKL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24049", "l": "phosphate + sucrose => alpha-D-glucose 1-phosphate + D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22717", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421515", "l": "uroporphyrinogen III => coproporphyrinogen III + 4 CO2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26490", "l": "a secondary nitroalkane + H2O + O2 = a ketone + H(+) + H2O2 + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48615", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] <=> [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932021", "l": "RUNX1 and ESR1 bind the GPAM gene enhancer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24609", "l": "5-dehydro-4-deoxy-D-glucarate + H(+) => 2,5-dioxopentanoate + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684273", "l": "3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44782", "l": "H(+) + menaquinol-9 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-9 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5227009", "l": "ABCF1 binds EIF2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60623", "l": "N-hexanoyl-sphing-4-enine-1-phosphocholine <=> choline + N-(hexanoyl)-sphing-4-enine-1,3-cyclic phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40809", "l": "(9Z)-octadecenoate + H(+) + sn-glycerol 3-phosphocholine => a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0035673", "l": "oligopeptide transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948136", "l": "ULK1 Translocates to the mitochondria (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2025890", "l": "Calcineurin binds NFATC1,2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33481", "l": "CoA + lanosteryl ester => an acyl-CoA + lanosterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11237", "l": "putrescine + spermidine => propane-1,3-diamine + sym-homospermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11251", "l": "[(3R)-hydroxybutanoate](n) + H2O <=> (R)-3-hydroxybutanoate + [(3R)-hydroxybutanoate](n-1) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25468", "l": "(2E,6E)-farnesyl diphosphate = beta-himachalene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49620", "l": "D-erythritol 1-phosphate + NADP(+) = D-erythrulose 1-phosphate + H(+) + NADPH"}, {"i": "EC:1.1.1.402", "l": "\"D-erythritol 1-phosphate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112392", "l": "Resumption of elongation after recovery from pausing (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41378", "l": "1-O-decyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-decyl-2-acetyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408500", "l": "GSSeH condenses with GSH to form H2Se and GSSG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-179417", "l": "Multiubiquitination of Nek2A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0000400", "l": "four-way junction DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9706393", "l": "RHOBTB3 binds ATP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70573", "l": "argininosuccinate <=> fumarate + arginine (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17742", "l": "NAD(+) + shikimate => 3-dehydroshikimate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419334", "l": "Melatonin receptors can bind melatonin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44033", "l": "9,10-epoxy-(12Z)-octadecenoate + H2O => 9,10-dihydroxy-(12Z)-octadecenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52680", "l": "acetyl-CoA + L-alpha-phenylglycine = CoA + H(+) + N-acetyl-L-alpha-phenylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10303", "l": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate <=> (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676229", "l": "WIPIs bind PI3P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58563", "l": "15alpha-stemmadenine intermediate II + NADP(+) <=> 15alpha-stemmadenine intermediate I + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192051", "l": "CYP7A1 7-hydroxylates CHOL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14952", "l": "A + H2O + quinoline-4-carboxylate <=> 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15010", "l": "(6S)-5,6,7,8-tetrahydrofolate + NADP(+) => 7,8-dihydrofolate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047258", "l": "sphingosine beta-galactosyltransferase activity"}, {"i": "KEGG.REACTION:R01928"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23712", "l": "NADP(+) + pregnan-21-ol = H(+) + NADPH + pregnan-21-al"}, {"i": "EC:1.1.1.151", "l": "\"21-hydroxysteroid dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65961", "l": "ATP + H2O + leukotriene C4(out) => ADP + H(+) + leukotriene C4(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43275", "l": "ganglioside GD3 + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GD2 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59940", "l": "2-methyloctadecanoyl-CoA + H2O = 2-methyloctadecanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-179421", "l": "Degradation of multiubiquitinated Nek2A (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33096", "l": "chorismate + inosine + phosphoenolpyruvate => futalosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39104", "l": "(24R)-ethylcholest-5-en-3beta-ol(in) + ATP + H2O => (24R)-ethylcholest-5-en-3beta-ol(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696183", "l": "AOC3 deaminates BZAM (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24082", "l": "AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp) => ATP + L-tryptophan + tRNA(Trp)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391377", "l": "Luteinizing hormone receptor can bind LH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23997", "l": "a ribonucleoside 5'-triphosphate + H2O => a ribonucleoside 5'-phosphate + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56450", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374667", "l": "DCC interaction with SIAH2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11913", "l": "13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) => 15-oxoprostaglandin E2 + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44342", "l": "AMP + diphosphate + N(3)-fumaroyl-(S)-2,3-diaminopropanoate => (S)-2,3-diaminopropanoate + ATP + fumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51618", "l": "CO2 + dATP + H2O => ATP + formate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.105", "l": "\"2-hydroxyisoflavanone dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114284", "l": "Release of Cytochrome c from mitochondria (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30024", "l": "L-alanine + pyridoxal 5'-phosphate => pyridoxamine 5'-phosphate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40213", "l": "3-oxotetradecanedioyl-CoA + H(+) + NADH => (3S)-hydroxytetradecanedioyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5252001", "l": "ATP1B4 binds SNW1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54102", "l": "H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-984689", "l": "Kinesin-7 is a dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21494", "l": "catechol + CO2 => 2,3-dihydroxybenzoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614778", "l": "MAG gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14600", "l": "a CDP-1,2-diacyl-sn-glycerol + choline <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3364014", "l": "Recruitment of SET1 methyltransferase complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198813", "l": "GSTO dimers reduce DeHA to AscH- (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009381", "l": "excinuclease ABC activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24802", "l": "2-oxoglutarate + L-isoleucine => (S)-3-methyl-2-oxopentanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36611", "l": "(3S,5S)-carbapenam-3-caboxylate + 2-oxoglutarate + O2 = (5R)-carbapenem-3-carboxylate + CO2 + H2O + succinate"}, {"i": "EC:1.14.20.3", "l": "\"(5R)-carbapenem-3-carboxylate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40951", "l": "(2S)-2-acetamido-4-aminobutanoate + H2O = acetate + L-2,4-diaminobutanoate"}, {"i": "EC:3.5.1.125", "l": "\"N(2)-acetyl-L-2,4-diaminobutanoate deacetylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033442", "l": "AAC codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592387", "l": "Fibulin binds elastic fibres (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37183", "l": "(9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate = 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295622", "l": "SPRY2 binds CBL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57245", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP => dGTP + H(+) + lactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676589", "l": "RANKL,sRANKL trimer binds RANK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641206", "l": "RSPOs bind LGRs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39487", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA = (2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75856", "l": "Abortive Initiation Before Second Transition (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011543", "l": "DCA binds PDK2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3965450", "l": "DAAM1 recruits PFN1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102147", "l": "3'-O-methyltricetin O methyl transferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102337", "l": "3-oxo-cerotoyl-CoA synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404142", "l": "atROL binds RBP1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30454", "l": "(S)-2,3-epoxysqualene <=> isomultiflorenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37475", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2569057", "l": "RIP3 binds TRIF to mediate necroptosis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630043", "l": "Defective NTHL1 truncation mutants do not bind thymine glycol (Tg) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64144", "l": "H2O + N-(9Z-octadecenoyl)-L-methionine = (9Z)-octadecenoate + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222237", "l": "SMYD2 methylates TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37175", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73757", "l": "Binding of RRN3 to RNA Polymerase I (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132248", "l": "C4b binds to target cell surface (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41522", "l": "H(+) + H2O + omega-hydroxymenaquinone-4 + oxidized [NADPH--hemoprotein reductase] => menaquinone-4 + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047311", "l": "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase activity"}, {"i": "RHEA:15497", "l": "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate = 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine"}, {"i": "EC:2.6.1.56", "l": "\"1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672178", "l": "PI3-kinase binds to PDGFRA extracellular domain dimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396009", "l": "STING binds c-di-GMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40204", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0004611", "l": "phosphoenolpyruvate carboxykinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61454", "l": "11a-hydroxy-oxytetracycline + H2O + NADP(+) => H(+) + NADPH + O2 + oxytetracycline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204600", "l": "Basigin homodimerises (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14229", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.5.7.1", "l": "\"Methylenetetrahydrofolate reductase (ferredoxin)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015434", "l": "ABC-type cadmium transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381799", "l": "Synthesis of Preproglucagon in intestinal L cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417908", "l": "P2RY1 binds ADP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39376", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA => (2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57357", "l": "2-oxoglutarate + chloride + H(+) + hapalindole U + O2 => CO2 + H2O + hapalindole G + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189406", "l": "4 PBGs bind to form HMB (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51781", "l": "4-prenylphlormethylbutanophenone + dimethylallyl diphosphate => deoxyadlupulone + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391934", "l": "DP2 receptor can bind PGD2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734730", "l": "ORC1 translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41274", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38727", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626228", "l": "The distal appendage proteins recruit TTBK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23951", "l": "4-hydroxybutanoate + NAD(+) <=> H(+) + NADH + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60027", "l": "(R,R)-chrysanthemyl diphosphate + H2O <=> (R,R)-chrysanthemol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035514", "l": "Defective ALG9 does not add the last mannose to the N-glycan precursor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26156", "l": "D-mannose + NADP(+) = D-glucosone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34455", "l": "all-trans-beta-carotene = 9-cis-beta-carotene"}, {"i": "EC:5.2.1.14", "l": "\"Beta-carotene isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25305", "l": "7,8-dihydroneopterin 3'-triphosphate + H2O <=> 7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46145", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38737", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-hexadecanoylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672817", "l": "Active MTORC1 binds the ULK1 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102556", "l": "dammarenediol 12-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018031", "l": "peptidyl-lysine N6-palmitoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106302", "l": "arachidonic acid 8,9-epoxygenase activity"}, {"i": "RHEA:64984", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102434", "l": "pterin-4alpha-carbinolamine dehydratase activity"}, {"i": "MetaCyc:RXN-13908"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33585", "l": "2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate => L-glutamate + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24723", "l": "H(+) + L-methionyl(44)-[F-actin] + NADPH + O2 => H2O + L-methionyl(44)-(R)-S-oxide-[F-actin] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56962", "l": "a ribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate => a ribonucleoside 5'-triphosphate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11087", "l": "3-dehydro-L-gulonate + H(+) <=> CO2 + L-xylulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102927", "l": "beta-chaconine rhamnosyltransferase activity"}, {"i": "MetaCyc:RXN-8883"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174058", "l": "Degradation of multiubiquitinated Cdh1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29713", "l": "cadaverine(out) + H(+)(out) => cadaverine(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19542", "l": "L-glutamate 5-semialdehyde + NADP(+) + phosphate => H(+) + L-glutamyl 5-phosphate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62838", "l": "GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosamine => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0042324", "l": "hypocretin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13935", "l": "all-trans-retinol + H(+) + hexadecanoate => all-trans-retinyl hexadecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052767", "l": "mannosyl-oligosaccharide 1,6-alpha-mannosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2430535", "l": "MASTL phosphorylates ENSA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36382", "l": "4alpha-methyl-5alpha-cholesta-8,24-dien-3-one + H(+) + NADPH <=> 4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45452", "l": "H2O + N-tetradecanoylethanolamine = ethanolamine + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8934742", "l": "RUNX1 binds PRMT1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44964", "l": "(2E)-dodecenoyl-CoA + H(+) + NADPH = dodecanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40716", "l": "dihydroxyacetone phosphate + hexadecanoyl-CoA => 1-hexadecanoylglycerone 3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56441", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20084", "l": "H2O + N-methylhexanamide <=> hexanoate + methylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373716", "l": "DCC interacting NCK-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31628", "l": "10-deoxymethynolide + dTDP-alpha-D-desosamine => 10-deoxymethymycin + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19731", "l": "acetone + CO2 => acetoacetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59692", "l": "D-cellotriono-1,5-lactone + H2O = D-cellotrionate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871227", "l": "RET binds GFRA4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47153", "l": "2,5-dioxopentanoate + H2O + NAD(+) => 2-oxoglutarate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655290", "l": "Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917693", "l": "ESCRT Disassembly (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23282", "l": "CoA + S-acetylcysteamine => acetyl-CoA + cysteamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61912", "l": "ATP + H2O + voriconazole(in) = ADP + H(+) + phosphate + voriconazole(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187045", "l": "The signal peptide is excised from beta-NGF pre-pro-precursor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60639", "l": "N-(dodecanoyl)-sphing-4-enine-1-phosphocholine <=> choline + N-dodecanoyl-sphing-4-enine-1,3-cyclic phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56194", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56057", "l": "genistein + UDP-alpha-D-glucose => genistein 7-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429694", "l": "CERT:PPM1L:VAPA/B [ER] => CERT [cytosol] + PPM1L:VAPA/B [ER] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017103", "l": "UTP:galactose-1-phosphate uridylyltransferase activity"}, {"i": "RHEA:14209", "l": "alpha-D-galactose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-galactose"}, {"i": "EC:2.7.7.10", "l": "\"UTP--hexose-1-phosphate uridylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52705", "l": "H2O + UMP => D-ribose 5-phosphate + uracil"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047043", "l": "3-alpha-hydroxycholanate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047663", "l": "aminoglycoside 6'-N-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61321", "l": "(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + parthenolide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60929", "l": "(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => 17-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202137", "l": "AKT1 binds eNOS complex via HSP90 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17084", "l": "S-adenosyl-L-methionine + trans-isoeugenol <=> H(+) + S-adenosyl-L-homocysteine + trans-isomethyleugenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645535", "l": "ALPK1 phosphorylates TIFA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37622", "l": "(9Z)-octadecenoyl-CoA + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20574", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => calcitriol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16513", "l": "(S)-lactate + O2 = acetate + CO2 + H2O"}, {"i": "EC:1.13.12.4", "l": "\"Lactate 2-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199062", "l": "KLRC1:KLRD1 heterodimer interacts with HLA-E (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65485", "l": "hexan-1-ol + hexanoyl-CoA => CoA + hexyl hexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11057", "l": "4-aminobenzoate + 2 H(+) + NADPH + O2 => 4-aminophenol + CO2 + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40597", "l": "CoA + dodecanedioate + H(+) => dodecanedioyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18140", "l": "3beta-hydroxy-5alpha-pregnane-20-one + NADP(+) <=> 5alpha-pregnane-3,20-dione + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026001", "l": "Hydroperoxy reductase reduces 7,17-diHp-DPAn-3 to RvD5n-3DPA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37392", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-(9Z)-octadecaenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990698", "l": "palmitoleoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32230", "l": "(6R)-NADPHX <=> (6S)-NADPHX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47850", "l": "CO2 + diphosphate + thiamine phosphate => 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21497", "l": "dimethylallyl diphosphate + H2O => diphosphate + prenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163090", "l": "Elongation Of The Telomeric Chromosome End (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57019", "l": "3,6-dichloro-2-methoxybenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3,6-dichlorosalicylate + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51125", "l": "uridine in snRNA => pseudouridine in snRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990763", "l": "arrestin family protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34886", "l": "ATP + H2O + selenate(out) <=> ADP + H(+) + phosphate + selenate(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038149", "l": "C-C motif chemokine 2 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694421", "l": "PP6 dephosphorylates SEC24 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45378", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + sphinganine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17245", "l": "3-hydroxyanthranilate + O2 = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2"}, {"i": "EC:1.10.3.5", "l": "\"3-hydroxyanthranilate oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.77", "l": "\"Oleate 10S-lipoxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35726", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphate <=> 1-hexadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14518", "l": "(E)-feruloyl-CoA + H2O => 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-349455", "l": "Phosphorylation of MDM4 by ATM (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665767", "l": "Activated FMNL3 binds G-actin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59670", "l": "D-cellohexaono-1,5-lactone + H2O2 => D-cellohexaose + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25682", "l": "L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55046", "l": "(3E,5Z)-tetradecadienoate + CoA + H(+) => (3E,5Z)-tetradecadienoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17988", "l": "4-(trimethylamino)butanal + H2O + NAD(+) <=> 4-(trimethylamino)butanoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9639286", "l": "RRAGC,D exchanges GTP for GDP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37397", "l": "1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809254", "l": "MTMR8 binds MTMR9 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25003", "l": "H(+) + N,N-dihydroxy-L-phenylalanine <=> (E)-phenylacetaldehyde oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-166220", "l": "FA anion diffuses laterally to UCP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610195", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN2D (GRIN2D) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102246", "l": "6-amino-6-deoxyfutalosine hydrolase activity"}, {"i": "MetaCyc:RXN-12346"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-517674", "l": "p-S158,221-HuR binds mRNA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5082356", "l": "HSF1-mediated gene expression (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390886", "l": "HRH4 binds Hist (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028724", "l": "AMOT proteins bind YAP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36425", "l": "2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine => 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25704", "l": "H(+) + H2O + N,N-dihydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56812", "l": "2-oxoglutarate + chloride + H(+) + L-threonyl-[peptidyl-carrier protein] + O2 = 4-chloro-L-threonyl-[peptidyl-carrier protein] + CO2 + H2O + succinate"}, {"i": "EC:1.14.20.15", "l": "\"L-threonyl-[L-threonyl-carrier protein] 4-chlorinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-9635428", "l": "FadD26, FadD28 transfer LCFA adenylate ester to Pks5 (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67019", "l": "a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] <=> a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63075", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4 CO2 + 4 CoA + orcinol"}]}
{"type": "biolink:MolecularActivity", "ic": "72.96845868813736", "identifiers": [{"i": "GO:0019213", "l": "deacetylase activity"}, {"i": "REACT:R-HSA-5689000", "l": "AADAC deacetylates PHEN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112434", "l": "Formation of DSIF complex  (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0019957", "l": "C-C chemokine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63811", "l": "ATP + citrate + spermidine <=> AMP + diphosphate + H(+) + N(8)-citryl-spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4649028", "l": "TLE forms non-functional complexes with AES (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204779", "l": "Interaction of Tie2 with Ang1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18169", "l": "4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate"}, {"i": "EC:4.1.3.16", "l": "\"4-hydroxy-2-oxoglutarate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2316352", "l": "SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0089710", "l": "endocytic targeting sequence binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53692", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O = H(+) + prostaglandin E2 + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851436", "l": "CFHR dimers bind C3b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448958", "l": "Nuclear translocation of p38 MAPK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0004311", "l": "farnesyltranstransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17768", "l": "(2R)-3-phospho-glyceroyl phosphate <=> (2R)-2,3-bisphosphoglycerate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40593", "l": "CoA + decanedioate + H(+) => decanedioyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28237", "l": "L-glutamate 5-semialdehyde <=> (S)-1-pyrroline-5-carboxylate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.149", "l": "\"Lycopene elongase/hydratase (flavuxanthin-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19669", "l": "GTP + H2O = GDP + H(+) + phosphate"}, {"i": "EC:3.6.5.1", "l": "\"Heterotrimeric G-protein GTPase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047839", "l": "dATP(dGTP)-DNA purinetransferase activity"}, {"i": "MetaCyc:DATPDGTP--DNA-PURINE-TRANSFERASE-RXN"}, {"i": "EC:2.6.99.1", "l": "\"dATP(dGTP)--DNA purinetransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54113", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + selina-4(15),7(11)-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180603", "l": "Proteosome-mediated degradation of APOBEC3G (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110322", "l": "Formation of Pol zeta complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30944", "l": "FAD + H(+) + octanoyl-CoA => (2E)-octenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62971", "l": "(R)-lactate + NADP(+) <=> H(+) + NADPH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47343", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047601", "l": "acetate kinase (diphosphate) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32356", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + 2 UDP-alpha-D-glucose => 2 H(+) + ternatin C5 + 2 UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44944", "l": "1-O-alkyl-3-acyl-sn-glycerol + H2O = 1-O-alkyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53279", "l": "17beta-hydroxy-3,19-dioxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta-hydroxy-3-oxo-19-nor-5alpha-androst-1-ene + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-481044", "l": "Surface deployment of platelet alpha granule membrane components (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65715", "l": "alpha-D-glucose 1-phosphate + GDP-beta-L-galactose <=> beta-L-galactose 1-phosphate + GDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-169895", "l": "Crk's SH3 domain engages C3G (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16072", "l": "cytidine + H(+) + H2O <=> NH4(+) + uridine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32359", "l": "1D-myo-inositol 1,4,5-trisphosphate + 2 ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)"}, {"i": "EC:2.7.1.151", "l": "\"Inositol-polyphosphate multikinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018768", "l": "RHOU auto-activates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668735", "l": "RAC1:GTP binds NOX3 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873921", "l": "Binding of STAT1 to p-IFNGR1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55725", "l": "17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] => 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12514", "l": "H2O2 + NH4(+) + oxaloacetate => D-aspartate + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008968", "l": "D-sedoheptulose 7-phosphate isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295632", "l": "PPA2A dephosphorylates SPRY2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606288", "l": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029270", "l": "Recruitment of PLCgamma to membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850534", "l": "PDCL promotes G-protein beta 5 folding (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866851", "l": "CFTR transits to the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052731", "l": "phosphocholine phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20516", "l": "2-aryl-2-methylmalonate + H(+) <=> 2-arylpropionate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190829", "l": "Lysosomal degradation of gap junction plaques (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12141", "l": "a 2'-deoxyribonucleoside + ATP => a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21915", "l": "CoA + H(+) + O2 + pyruvate <=> acetyl-CoA + CO2 + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37194", "l": "2',3'-cyclic AMP + H2O <=> adenosine 2'-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51962", "l": "2-methylpropanenitrile + H2O => (Z)-2-methylpropanal oxime"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35889", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693598", "l": "ATM phosphorylates NBN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5323526", "l": "FRAT proteins bind GSK3beta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25262", "l": "2-hydroxyglutarate + FAD + H(+) => 2-oxoglutarate + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36428", "l": "2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => diphthine-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47400", "l": "3-oxo-(9Z-octadecenoyl)-CoA + CoA = (7Z)-hexadecenoyl-CoA + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31369", "l": "H2O + nitrate + 2 nitric oxide => 2 H(+) + 3 nitrite"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0042979", "l": "ornithine decarboxylase regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662466", "l": "XYLB phosphorylates D-xylulose (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-264622", "l": "Cho is acetylated to AcCho by CHAT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606273", "l": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1474266", "l": "Formation of collagen fibrils (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018584", "l": "2,4,5-trichlorophenoxyacetic acid oxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33552", "l": "an N-acylsphinganine + H2O => a fatty acid + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59000", "l": "H2O + O2 + propanal = H(+) + H2O2 + propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36659", "l": "carbamoyl phosphate + descarbamoylnovobiocin = novobiocin + phosphate"}, {"i": "EC:2.1.3.12", "l": "\"Decarbamoylnovobiocin carbamoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72672", "l": "The 60S subunit joins the translation initiation complex  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875451", "l": "MET phosphorylates CBL (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201634", "l": "Caspase-mediated cleavage of FADK 1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15510", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10483", "l": "2-oxoglutarate + 4-hydroxy-L-glutamate <=> 4-hydroxy-2-oxoglutarate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5357472", "l": "PAK1-3 autophosphorylates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45678", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47182", "l": "(25R)-7alpha,26-dihydroxycholest-4-en-3-one + H(+) + NADH => (25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098919", "l": "structural constituent of postsynaptic density"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45927", "l": "9-decenoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(2-oxoundec-10-en-1-yl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49213", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,25-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-164423", "l": "PhosphoChREBP (Thr 666)  is exported to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46509", "l": "NADH + nitrobenzene + O2 => catechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72143", "l": "Lariat Formation and 5'-Splice Site Cleavage (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44711", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14852", "l": "H2O + N-amidino-L-aspartate <=> L-aspartate + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2002428", "l": "Removal of fibrillar collagen N-propeptides (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54902", "l": "hexadecanoyl-[ACP] + NAD(+) => (2E)-hexadecenoyl-[ACP] + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42318", "l": "an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1297333", "l": "Association of Acrosin Heavy and Light Chain (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445700", "l": "Myosin Binds ATP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1564120", "l": "Collagen type VII degradation by MMP1,2,3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5250217", "l": "ARL2:GTP binds ARL2BP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008022", "l": "protein C-terminus binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169406", "l": "ISGylation of host proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432067", "l": "Aquaporin-4 passively transports water out of cell (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50384", "l": "H(+) + oxidized coenzyme F420-(gamma-Glu)(n) + tetracycline = 5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-Glu)(n)"}, {"i": "RHEA:50392", "l": "H(+) + oxidized coenzyme F420-(gamma-Glu)(n) + oxytetracycline = 5a,11a-dehydrooxytetracycline + reduced coenzyme F420-(gamma-Glu)(n)"}, {"i": "EC:1.3.98.4", "l": "\"5a,11a-dehydrotetracycline reductase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102354", "l": "11-cis-retinol dehydrogenase activity"}, {"i": "RHEA:54912", "l": "11-cis-retinol + NADP(+) = 11-cis-retinal + H(+) + NADPH"}, {"i": "MetaCyc:RXN-13363"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016232", "l": "HNK-1 sulfotransferase activity"}, {"i": "REACT:R-HSA-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134954", "l": "DHX9 binds DNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120204", "l": "methylcytosine to 5-glyceryl-methylcytosine dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794345", "l": "NLGNs binds PSD-95 subfamily members (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59859", "l": "[Co(I) tetramethylammonium-specific corrinoid protein] + H(+) + tetramethylammonium <=> [methyl-Co(III) tetramethylammonium-specific corrinoid protein] + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70971", "l": "citrate <=> isocitrate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25693", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) <=> CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15990", "l": "(R)-mevalonate + CoA + 2 NADP(+) => (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10566", "l": "H(+) + methanol + oxaloacetate => H2O + oxaloacetate 4-methyl ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170120", "l": "Translocation of Cdc25B to the cytoplasm (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174967", "l": "NAT2 acetylation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61121", "l": "kaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 2 H2O + myricetin + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031765", "l": "type 2 galanin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62886", "l": "2 (M)-viriditoxin + 2 H2O => O2 + 4 semiviriditoxin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390886", "l": "HRH4 binds Hist (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10137", "l": "2 glyoxylate + H(+) => 2-hydroxy-3-oxopropanoate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875591", "l": "DOCK7 activates RAC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0098879", "l": "structural constituent of postsynaptic specialization"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213246", "l": "Disassociation of CLIP from MHC II (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730858", "l": "Autophosphorylation of BTK/ITK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549322", "l": "OCT1 transports organic cations out of hepatic cells (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40735", "l": "(20S)-ginsenoside Rb1 + 2 H2O = 2 D-glucose + gypenoside LXXV"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013147", "l": "RAC1 GDIs block activation of RAC1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805103", "l": "AURKA phosphorylates TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785181", "l": "LMF1,2 bind LIPC dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25805", "l": "H2O + O2 + spermine => 3-aminopropanal + H2O2 + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44683", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30993", "l": "24-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58567", "l": "15alpha-stemmadenine + NADP(+) <=> 15alpha-stemmadenine intermediate II + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211164", "l": "AKT phosphorylates FOXO1A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198440", "l": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5684052", "l": "PIAS4 SUMOylates MDC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57450", "l": "AMP + D-tyrosyl-tRNA(Tyr) + diphosphate + H(+) => ATP + D-tyrosine + tRNA(Tyr)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-264615", "l": "Loading of acetylcholine in synaptic vesicles (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16423", "l": "a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16083", "l": "(2R)-S-methyl-1-thioglycerate + phosphate => (2R)-S-methyl-3-phospho-1-thioglycerate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.86", "l": "\"Ketol-acid reductoisomerase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20723", "l": "H2O + isopenicillin N + phenylacetyl-CoA <=> CoA + H(+) + L-2-aminoadipate + penicillin G"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51086", "l": "16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49793", "l": "eicosanoyl-CoA + glycine => CoA + H(+) + N-eicosanoylglycinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3814820", "l": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034898", "l": "hexadecyltrimethylammonium chloride monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668023", "l": "TPST1,2 transfer SO4(2-) from PAPS to FVIII (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16749", "l": "H2O + phosphonoacetate = acetate + H(+) + phosphate"}, {"i": "EC:3.11.1.2", "l": "\"Phosphonoacetate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32037", "l": "(2Z,4Z)-2-hydroxyhexa-2,4-dienoate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + H(+) => (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032500", "l": "muramyl dipeptide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349426", "l": "Phosphorylation of MDM4 by CHEK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102821", "l": "bixin methyltransferase activity"}, {"i": "MetaCyc:RXN-8239"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218814", "l": "PAK2 autophorylates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72672", "l": "The 60S subunit joins the translation initiation complex  (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156912", "l": "Peptide transfer from P-site tRNA to the A-site tRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42030", "l": "7-oxolithocholate + H(+) + NADH => NAD(+) + ursodeoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794348", "l": "NRXNs bind  SYTs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003910", "l": "DNA ligase (ATP) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27533", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (3S,6E)-nerolidol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57492", "l": "H2O + oxaloacetate + propanoyl-CoA = 2-methylcitrate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12269", "l": "2-oxoglutarate + putrescine => 1-pyrroline + H2O + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112604", "l": "Phosphorylated STATs are released (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374173", "l": "AGT(34-41) binds to AGTR1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55537", "l": "an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose => a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029468", "l": "Conversion of PA into DAG by PAP-1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948226", "l": "Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36781", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate => 2-oxoglutarate + GDP-alpha-D-perosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390597", "l": "Release Of ADP From Myosin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799761", "l": "TP53 binds PPP1R13L (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20121", "l": "ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)"}, {"i": "EC:6.1.1.18", "l": "\"Glutamine--tRNA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30052", "l": "fluoroacetate + H2O => fluoride + glycolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "79.238648346243679", "identifiers": [{"i": "GO:0016859", "l": "cis-trans isomerase activity"}, {"i": "EC:5.2.-.-", "l": "\"Cis-trans-isomerases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809309", "l": "MTMR6 binds MTMR9 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33458", "l": "4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) <=> CO2 + NADPH + zymosterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33173", "l": "D-maltose(out) => D-maltose(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5226979", "l": "ADD1:ADD2 binds DMTN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62939", "l": "H2O + N(4)-acetyl-2'-deoxycytidine <=> 2'-deoxycytidine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30092", "l": "a ubiquinone + D-alanine + H2O => a ubiquinol + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013438", "l": "RHOD binds effectors at the endosome membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870461", "l": "RABGGTA and RABGGTB bind (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.5", "l": "\"Aldehyde dehydrogenase (NAD(P)(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44733", "l": "2-(9Z,12Z-octadecadienoyl)-glycerol + H2O => (9Z,12Z)-octadecadienoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49207", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,24R-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23485", "l": "A + D-cellobiose => AH2 + D-cellobiono-1,5-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35338", "l": "H(+) + isopentadecanoyl-CoA + malonyl-CoA <=> 3-oxoisoheptadecanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64378", "l": "a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 8 AH2 => 8 A + a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49227", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + reduced [flavodoxin] <=> dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H(+) + H2O + oxidized [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018456", "l": "aryl-alcohol dehydrogenase (NAD+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18014", "l": "H2O + N(5)-ethyl-L-glutamine => ethylamine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53149", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41663", "l": "dihydrosanguinarine + NAD(+) <=> NADH + sanguinarine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15984", "l": "H(+) + S-adenosyl-L-methionine <=> CO2 + S-adenosyl 3-(methylsulfanyl)propylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52797", "l": "2 H(+) + Ni-sirohydrochlorin => Ni(2+) + sirohydrochlorin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5250930", "l": "B-WICH recruits histone acetyltransferases (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10215", "l": "2-oxoglutarate + 5-aminopentanoate <=> 5-oxopentanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54056", "l": "(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-hedycaryol + diphosphate"}, {"i": "EC:4.2.3.174", "l": "\"(2E,6E)-hedycaryol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2467811", "l": "Separation of sister chromatids (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36365", "l": "(9Z,12Z)-octadecadien-1-ol + CoA + 2 NADP(+) => (9Z,12Z)-octadecadienoyl-CoA + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102453", "l": "anthocyanidin 3-O-glucoside 6''-O-acyltransferase activity"}, {"i": "RHEA:35411", "l": "(E)-4-coumaroyl-CoA + an anthocyanidin 3-O-beta-D-glucoside = an anthocyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D--glucoside] + CoA + H(+)"}, {"i": "EC:2.3.1.215", "l": "\"Anthocyanidin 3-O-glucoside 6''-O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114354", "l": "SMAC binds XIAP:Caspase-7 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24279", "l": "acetate + diphosphate <=> acetyl phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49276", "l": "CTP + phytyl phosphate = CDP + phytyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35662", "l": "an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + GDP-alpha-D-mannose <=> GDP + H(+) + mannosylinositol phosphorylphytoceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34449", "l": "dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH => dTDP-6-deoxy-beta-L-talose + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190256", "l": "FGFR1c binds to FGF (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50821", "l": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) => H(+) + NADPH + testosterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630923", "l": "NFkB inhibitor binds NFkB complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031961", "l": "cortisol receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5617815", "l": "BBSome binds RAB3IP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38122", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol <=> 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43227", "l": "(24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> (24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663155", "l": "p-BMAL1:p-CLOCK,NPAS2 binds NR1D1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45841", "l": "(3R)-3-hydroxydecanoyl-CoA + NADP(+) => 3-oxodecanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40306", "l": "A + dodecanedioyl-CoA <=> (2E)-dodecenedioyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29604", "l": "benzoyl-CoA + H2O + oxidized 2[4Fe-4S]-[ferredoxin] => 4-hydroxybenzoyl-CoA + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57003", "l": "acetyl-CoA + streptothricin F <=> CoA + H(+) + N(beta)-acetylstreptothricin F"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139919", "l": "Translocation of BIM to mitochondria (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11560", "l": "(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+) = catechol + CO2 + NADH"}, {"i": "EC:1.3.1.25", "l": "\"1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29584", "l": "guanosine(in) + H(+)(out) => guanosine(out) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43863", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) <=> 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201457", "l": "BMP2 binds to the receptor complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62856", "l": "GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005295", "l": "neutral amino acid:sodium symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018768", "l": "RHOU auto-activates (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018558", "l": "5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38617", "l": "ADP-D-ribose => cyclic ADP-ribose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60430", "l": "(indol-3-yl)acetate + L-aspartate => (indol-3-yl)acetyl-L-aspartate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42748", "l": "cytidine(967) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.176", "l": "\"16S rRNA (cytosine(967)-C(5))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036320", "l": "mating-type P-factor pheromone receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57058", "l": "D-apionolactone + H(+) + NADH => D-apiofuranose + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035978", "l": "Defective HEXA does not cleave the terminal GalNAc from keratan sulfate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37872", "l": "2-heptyl-4(1H)-quinolone + H(+) + NADH + O2 => 2-heptyl-3-hydroxy-4(1H)-quinolone + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448673", "l": "Formation of caspase-1 p10/p20 dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41870", "l": "3-oxododecanoyl-[ACP] + CO2 + holo-[ACP] => decanoyl-[ACP] + H(+) + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55446", "l": "cochalate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + oleanolate + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44263", "l": "2 H(+) + hexadecanoyl-CoA + 2 malonyl-CoA <=> 4-hydroxy-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388560", "l": "EDNRA,EDNRB bind EDNs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374689", "l": "Neogenin binds Netrin-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61425", "l": "cis-cis-nepetalactol + NAD(+) => cis-cis-nepetalactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44459", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> a 1-acyl-sn-glycero-3-phosphocholine + a 1-O-acyl-N-acylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23122", "l": "a dipeptide(in) + ADP + H(+) + phosphate => a dipeptide(out) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656523", "l": "An anchoring protein ZFYVE9 (SARA) does not recruit SMAD2/3 to TGFB1:TGFBR2:p-TGFBR1 KD Mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41186", "l": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-octadecyl-sn-glycero-3-phosphocholine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663246", "l": "RORA, EP300 bind NPAS2 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102620", "l": "3-geranylgeranylindole NADPH:oxygen oxidoreductase (10,11-epoxidizing) activity"}, {"i": "MetaCyc:RXN-15495"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58943", "l": "(1R,2R,3R)-prephytoene diphosphate + H(+) + NADH <=> all-trans-lycopaoctaene + diphosphate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46473", "l": "4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56687", "l": "dihydrorhizobitoxine + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + rhizobitoxine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10335", "l": "a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10169", "l": "15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin] => biliverdin IXalpha + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37604", "l": "(11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58728", "l": "adenosine in rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951443", "l": "Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59616", "l": "beta-alanyl-L-arginine + H2O = beta-alanine + L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44458", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a 1-O-acyl-N-acylsphing-4-enine => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018580", "l": "nitronate monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637770", "l": "Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31708", "l": "2 H(+) + O2 + pentalen-13-ol + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37398", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046715", "l": "active borate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679029", "l": "C-ter TLR7 dimer binds HCQ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9681616", "l": "AP2 binds chlorpromazine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694421", "l": "PP6 dephosphorylates SEC24 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-418553", "l": "cAMP degradation by Phosphodiesterases (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008048", "l": "calcium sensitive guanylate cyclase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25442", "l": "delta-selinene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32161", "l": "A + H2O + queuosine(34) in tRNA => AH2 + epoxyqueuosine(34) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49121", "l": "H(+) + NADPH + O2 + protoviolaceinate => H2O + NADP(+) + violaceinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29962", "l": "alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044587", "l": "cellopentaose binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35718", "l": "(2S,3S)-versiconal hemiacetal acetate + H2O <=> (2S-3S)-versiconal hemiacetal + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.2", "l": "\"Pectate lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11187", "l": "3-(carbamoylamino)propanoate + 2 H(+) + H2O <=> beta-alanine + CO2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043856", "l": "anti-sigma factor antagonist activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47212", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061840", "l": "high-affinity ferrous iron transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64291", "l": "2 nataloe emodin + O2 + reduced [NADPH--hemoprotein reductase] <=> cladofulvin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696131", "l": "AOC1 deaminates Hist (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70420", "l": "HK1,2,3,GCK phosphorylate Glc to form G6P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994034", "l": "Expression of Interferon-alpha and beta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788999", "l": "HV1-mediated H+ transfer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63753", "l": "kermesate + UDP-alpha-D-glucose => carminate + 2 H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004035", "l": "alkaline phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11530", "l": "2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate => 2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163625", "l": "Glucagon binds to Glucagon receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000156", "l": "phosphorelay response regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381644", "l": "ER calcium channels open in response to activated PKA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34541", "l": "methanetellurite + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + tellurite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987120", "l": "JAK1 binds IFNLR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033950", "l": "xyloglucan-specific exo-beta-1,4-glucanase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190256", "l": "FGFR1c binds to FGF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050053", "l": "levansucrase activity"}, {"i": "RHEA:13653", "l": "[6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose = [6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose"}, {"i": "EC:2.4.1.10", "l": "\"Levansucrase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57703", "l": "a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682598", "l": "ATM phosphorylates HERC2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371422", "l": "ATP hydrolysis by HSP70 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2318752", "l": "miR-26A microRNAs bind PTEN mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004014", "l": "adenosylmethionine decarboxylase activity"}, {"i": "MetaCyc:SAMDECARB-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9656947", "l": "OGG1beta translocates to mitochondria (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10288", "l": "H2O + L-rhamnono-1,4-lactone = H(+) + L-rhamnonate"}, {"i": "EC:3.1.1.65", "l": "\"L-rhamnono-1,4-lactonase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25777", "l": "scyllo-inosose => scyllo-inosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36326", "l": "(9Z)-octadecenoyl-CoA + 2 H(+) + 2 NADPH <=> (9Z)-octadecen-1-ol + CoA + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29091", "l": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28744", "l": "nitrate(in) + nitrite(out) => nitrate(out) + nitrite(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869580", "l": "DEK binds TFAP2A homodimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43167", "l": "7-cyano-7-deazaguanine + guanosine(15) in tRNA <=> 7-cyano-7-carbaguanosine(15) in tRNA + guanine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140344", "l": "triglyceride transfer activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50760", "l": "a quinone + H2O + sulfite = a quinol + sulfate"}, {"i": "EC:1.8.5.6", "l": "\"Sulfite dehydrogenase (quinone)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52550", "l": "2-dehydro-L-erythronate + H(+) + NADH => L-threonate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48596", "l": "1,2-didecanoylglycerol + H2O = decanoate + decanoylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625426", "l": "Retrograde IFT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352059", "l": "SLC6A15-mediated amino acid uptake (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21658", "l": "CDP-3,6-dideoxy-alpha-D-mannose => CDP-alpha-D-paratose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16104", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate <=> n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34979", "l": "H(+)(in) = H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57344", "l": "3-hydroxy-D-kynurenine + S-adenosyl-L-methionine = 3-hydroxy-4-methyl-D-kynurenine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63817", "l": "ATP + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine + spermidine => AMP + diphosphate + H(+) + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66090", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate => L-kynurenine + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63410", "l": "3,6-dihydroxypyridine-2,5-dione + chloride + FAD + 3 H(+) + H2O => 6-chloropyridine-2,3,5-triol + FADH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30809", "l": "Delta(1)-piperideine-2-carboxylate + H(+) + NADH => L-pipecolate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54294", "l": "3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate => ATP + L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42006", "l": "17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH => 5alpha-androstane-3alpha,17beta-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28129", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose <=> alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357472", "l": "PAK1-3 autophosphorylates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696564", "l": "USP25 deubiquitinates DDX58 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.2.1"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018458", "l": "isopiperitenol dehydrogenase activity"}, {"i": "RHEA:20860", "l": "(1S,6R)-isopiperitenol + NAD(+) = (6R)-isopiperitenone + H(+) + NADH"}, {"i": "EC:1.1.1.223", "l": "\"Isopiperitenol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730856", "l": "Autophosphorylation of PAK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944250", "l": "Association of procollagen type XXV (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14527", "l": "AH2 + alpha-cyclopiazonate => A + beta-cyclopiazonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57215", "l": "dGTP + methylglyoxal <=> N(2)-(1-hydroxy-2-oxopropyl)-dGTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22034", "l": "glyoxylate + oxaloacetate => 3-oxalomalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61198", "l": "CoA + H(+) + myricetin 3-O-[(6-O-[(E)-feruloyl]-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside] => (E)-feruloyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1362416", "l": "Frataxin binds iron (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444606", "l": "T1R2/T1R3 dimer is a sweet taste receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159733", "l": "Furin cleaves pro-factor X to factor X (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35901", "l": "1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA => 1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266328", "l": "CETP-mediated lipid exchange: spherical HDL gains triacylglycerol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43610", "l": "2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate => agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55539", "l": "an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose <=> a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5617815", "l": "BBSome binds RAB3IP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015655", "l": "alanine:sodium symporter activity"}, {"i": "RHEA:29283", "l": "L-alanine(in) + Na(+)(in) = L-alanine(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32724", "l": "L-trihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-6-(methylsulfanyl)hexanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12021", "l": "a monocarboxylic acid amide + H2O => a monocarboxylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.24", "l": "\"Aminopeptidase S\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004775", "l": "succinate-CoA ligase (ADP-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801101", "l": "RABGGTA binds RABGGTB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.88"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74711", "l": "Phosphorylation of IRS (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18208", "l": "AH2 + O2 + progesterone <=> 11alpha-hydroxyprogesterone + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62679", "l": "10-formyldihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide <=> 6-thio-IMP + 7,8-dihydrofolate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35762", "l": "8-O-methylsterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> aflatoxin B1 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362486", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5615682", "l": "Complexed PIWIL1 binds pre-piRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25728", "l": "N-hydroxy-L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32357", "l": "2 H(+) + ternatin C5 + 2 UDP => delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + 2 UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14685", "l": "A + a primary alcohol = AH2 + an aldehyde"}, {"i": "EC:1.1.99.20", "l": "\"Alkan-1-ol dehydrogenase (acceptor)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30748", "l": "FAD + H(+) + hexadecanoyl-CoA => (2E)-hexadecenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024624", "l": "Hydroperoxy reductase reduces 4(S)-Hp-17(R)-HDHA to AT-RvD6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011997", "l": "ESR1:ESTG, JUND:FOSB and Cohesin Complex bind distal enhancer elements in MYC gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029476", "l": "Role of myosins in phagosome formation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62154", "l": "dGDP + dTDP => dGMP + dTTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692134", "l": "Expression of FGF9 in testis differentiation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10624", "l": "2 ATP + CO2 + H2O + NH4(+) = 2 ADP + carbamoyl phosphate + 3 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53882", "l": "ADP + alpha,alpha-trehalose 6-phosphate + H(+) => ADP-alpha-D-glucose + D-glucose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37897", "l": "26-deglucoprotodioscin + D-glucose => H2O + protodioscin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391211", "l": "Trace amine-associated receptors can bind trace amines (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180687", "l": "Conversion of Ran-GDP to Ran-GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373711", "l": "DCC interaction with Netrin-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35082", "l": "doxorubicin(in) <=> doxorubicin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.23"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418200", "l": "SRC-1 bound to ARRB2 is not activated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69754", "l": "Phosphorylation of proteins involved in G2/M transition by active Cyclin A1:Cdc2 complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.103", "l": "\"Teichoic acid D-alanine hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640321", "l": "2,3-DKG hydrolyses to ERU and oxalate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989771", "l": "Expression of TNFRSF21 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58235", "l": "L-seryl-[protein] + NAD(+) <=> H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33703", "l": "(4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA = CoA + H(+) + N-hexacosanoyl-eicosan-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14772", "l": "(S)-nicotine + A + H2O <=> (S)-6-hydroxynicotine + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38370", "l": "8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA <=> 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57635", "l": "ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + ML-236A carboxylate + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694409", "l": "Nucleotide exchange on RAB1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55653", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854303", "l": "TBC1D11 binds RAB6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381109", "l": "IRE1 binds IRE1 forming dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43878", "l": "3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oyl-CoA + AMP + diphosphate => 3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48982", "l": "(2Z,4Z)-2,3-dichloromuconate + 2 H(+) => 3,4-dichlorocatechol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30746", "l": "beta-nicotinamide D-riboside + H2O <=> D-ribose + H(+) + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655839", "l": "Expression of Phosphomevalonate Kinase (PMVK) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24709", "l": "(6S)-10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + UDP-4-deoxy-4-formamido-beta-L-arabinose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23564", "l": "2 columbamine + O2 = 2 berberine + 2 H2O"}, {"i": "EC:1.21.3.2", "l": "\"Columbamine oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60985", "l": "16-hydroxyhexadecanoate + NAD(+) => 16-oxohexadecanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41102", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.44", "l": "\"Atrolysin E\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56156", "l": "(12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine = (12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983422", "l": "Disassembly of COPII coated vesicle (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114553", "l": "Activation of conventional Protein Kinase C (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34755", "l": "H2O + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine = D-glucose + N-acyl-15-methylhexadecasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43091", "l": "5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine <=> 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035966", "l": "Defective GGT1 does not hydrolyse GSH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706393", "l": "RHOBTB3 binds ATP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22556", "l": "(S)-malate + A = AH2 + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52791", "l": "chlorophyll a + 2 H(+) <=> Mg(2+) + pheophytin a"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30972", "l": "7,7',9,9'-tetra-cis-lycopene => all-trans-lycopene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428609", "l": "Type I Na+-coupled phosphate co-transport (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015478", "l": "oligosaccharide transporting porin activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004422", "l": "hypoxanthine phosphoribosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36085", "l": "1-O-alkyl-sn-glycerol + H(+) + phosphocholine => 1-O-alkyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11295", "l": "2 H(+) + O2 + rifamycin B <=> H2O2 + rifamycin O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371385", "l": "TNF-alpha is cleaved by ADAM17 (TACE) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433488", "l": "Phosphorylation of SHP2 by SFKs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684836", "l": "CLEC1B dimer binds PDPN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55001", "l": "3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202212", "l": "Recruitment of PLC-gamma1 to LAT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29727", "l": "ethane-1-sulfonate + FMNH2 + O2 = acetaldehyde + FMN + 2 H(+) + H2O + sulfite"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050584", "l": "linoleate 11-lipoxygenase activity"}, {"i": "MetaCyc:1.13.11.45-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55859", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981539", "l": "C3b binds to cell surface (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43024", "l": "an S-substituted L-cysteine = 2-aminoprop-2-enoate + a thiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202721", "l": "JAM2 binds JAM3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16130", "l": "NADP(+) + pyridoxine => H(+) + NADPH + pyridoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111962", "l": "PDE4A,C,D hydrolyse cAMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14168", "l": "acetyl-CoA + L-aspartate <=> CoA + H(+) + N-acetyl-L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390929", "l": "HTR1 and 5A receptors can bind serotonin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23523", "l": "acetyl-CoA + propanoate <=> acetate + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51178", "l": "5-methylcytidine(48) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(48) in tRNA(Asp) + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429699", "l": "CERT [ER] + ceramide [ER] => CERT:ceramide [ER] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21720", "l": "formamide = H2O + hydrogen cyanide"}, {"i": "EC:4.2.1.66", "l": "\"Cyanide hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114440", "l": "Dissociation of DIABLO:XIAP from the apoptosome complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65009", "l": "ATP + decanoate + H(+) => decanoyl-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55601", "l": "an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose => a mannosylinositol-1-phosphoceramide + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16635", "l": "guanine + queuosine(34) in tRNA => guanosine(34) in tRNA + queuine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21173", "l": "L-idonate + NAD(+) => 5-dehydro-D-gluconate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27757", "l": "H2O + methylglyoxal <=> (R)-lactate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005460", "l": "UDP-glucose transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015592", "l": "methylgalactoside transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700156", "l": "Active ALK dimer binds IRS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32712", "l": "a (3R)-3-hydroxyacyl-CoA + NAD(+) => a 3-oxoacyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203156", "l": "Platelet-derived TREM-1 ligand binds to TREM-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404193", "l": "IGF1R phosphorylates SHC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.12"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046911", "l": "metal chelating activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.26", "l": "\"DNA alpha-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42436", "l": "L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein] = L-ascorbate 6-phosphate(in) + L-histidyl-[protein]"}, {"i": "EC:2.7.1.194", "l": "\"Protein-N(pi)-phosphohistidine--L-ascorbate phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54926", "l": "3-oxo-(9Z)-hexadecenoyl-[ACP] + CO2 + holo-[ACP] => (7Z)-tetradecenoyl-[ACP] + H(+) + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264679", "l": "Serum albumin binds 2-lysophosphatidylcholine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52876", "l": "16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11543", "l": "an N-acyl-D-mannosamine + NAD(+) <=> an N-acyl-D-mannosaminolactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37802", "l": "2 H(+) + 2 NADH + O2 <=> 2 H2O + 2 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59647", "l": "D-xylobiono-1,5-lactone + H2O <=> D-xylobionate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57656", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1b = CMP + ganglioside GT1balpha + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848930", "l": "PTK6 translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46133", "l": "cholesterol + H(+) + NADPH + O2 => 25-hydroxycholesterol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619515", "l": "AMPK phosphorylates MAPT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53296", "l": "(2E)-decenoyl-CoA + NADP(+) = (2E,4E)-decadienoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003963", "l": "RNA-3'-phosphate cyclase activity"}, {"i": "MetaCyc:RNA-3-PHOSPHATE-CYCLASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23194", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371518", "l": "SIRT1 binds to HSF1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613760", "l": "EGR2 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5336184", "l": "GPR37L binds prosaposin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45694", "l": "N-(octanoyl)-sphing-4-enine-1-phosphate(out) => N-(octanoyl)-sphing-4-enine-1-phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28483", "l": "beta-nicotinamide D-ribonucleotide(in) => beta-nicotinamide D-ribonucleotide(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13511", "l": "diphosphate + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23465", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.23"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848873", "l": "PTK6 phosphorylates ARAP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59133", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP => AMP + diphosphate + H(+) + staphyloferrin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57240", "l": "glyoxal + GMP = N(2)-(1-hydroxy-2-oxoethyl)-GMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22110", "l": "2-oxobutanoate + NH4(+) => L-threonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49177", "l": "12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine => 12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0008237", "l": "metallopeptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39452", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA => (2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31405", "l": "all-trans-4,4'-diaponeurosporene + FADH2 => all-trans-4,4'-diapo-zeta-carotene + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061649", "l": "ubiquitin modification-dependent histone binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59648", "l": "D-xylotriono-1,5-lactone + H2O = D-xylotrionate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399939", "l": "Autophosphorylation of PAK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656070", "l": "FGFBPs bind FGFs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990631", "l": "ErbB-4 class receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981622", "l": "Myoglobin:oxygen dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38582", "l": "dammarenediol-II + O2 + reduced [NADPH--hemoprotein reductase] <=> (20S)-protopanaxadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111915", "l": "CAMK4 autophosphorylates (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449117", "l": "TXLNA (IL14) binds syntaxin1A (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "54.805387682399193", "identifiers": [{"i": "GO:0016758", "l": "hexosyltransferase activity"}, {"i": "EC:2.4.1.-", "l": "\"Hexosyltransferases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706298", "l": "Active FLT3 binds to CSK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5220959", "l": "TDG excises 5-formylcytosine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420206", "l": "Phosphorylation of SRC-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5333678", "l": "CPNEs bind PL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39656", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2 => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15809", "l": "(2E)-geranyl diphosphate + H2O = (R)-linalool + diphosphate"}, {"i": "EC:4.2.3.26", "l": "\"R-linalool synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004319", "l": "enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity"}, {"i": "MetaCyc:ENOYL-ACP-REDUCT-NADPH-RXN"}, {"i": "EC:1.3.1.10", "l": "\"Enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72130", "l": "Formation of an intermediate Spliceosomal C (Bact) complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41344", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = (5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32396", "l": "(1S,2S,4S)-dihydrocarveol + NAD(+) => (1S,4S)-dihydrocarvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45392", "l": "H2O + N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-eicosanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036173", "l": "thiosulfate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031527", "l": "Expression of APOC2 regulated by NR1H2 or NR1H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37064", "l": "2-thio-N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine => 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42413", "l": "(2R)-2,3-bisphosphoglycerate + ATP + H(+) => ADP + cyclic (2R)-2,3-bisphosphoglycerate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110218", "l": "Cleavage of uracil by TDG glycosylase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606327", "l": "Phosphorylation and release of IRF3  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2203516", "l": "Alpha-1-Microglobulin is cleaved (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362522", "l": "ALDHs oxidise atRAL to atRA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004352", "l": "glutamate dehydrogenase (NAD+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047772", "l": "carboxymethyloxysuccinate lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4086410", "l": "CDK1 phosphorylates BORA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374662", "l": "Translocation of Ezrin to plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64028", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8)-citryl-spermidine = H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10828", "l": "anthranilate + ATP + CoA = AMP + anthraniloyl-CoA + diphosphate"}, {"i": "EC:6.2.1.32", "l": "\"Anthranilate--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12967", "l": "1-phospho-alpha-D-galacturonate + ADP + H(+) => ATP + D-galacturonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948583", "l": "miR-17 microRNA binds CNOT6L mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52076", "l": "13-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114256", "l": "CYCS:APAF1 binds procaspase-9 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65451", "l": "butanoyl-CoA + ethanol <=> CoA + ethyl butanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38980", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51513", "l": "H2O + oxamate => NH4(+) + oxalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1454928", "l": "ABCG4 may mediate cholesterol efflux (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875591", "l": "DOCK7 activates RAC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63938", "l": "3 a ubiquinol + protoporphyrin IX => 3 a ubiquinone + protoporphyrinogen IX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20017", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2 = 5,10-methylenetetrahydromethanopterin + H(+)"}, {"i": "EC:1.12.98.2", "l": "\"5,10-methenyltetrahydromethanopterin hydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51330", "l": "10-hydroperoxy-(8Z,11Z,14Z)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000310", "l": "AURKA phosphorylates PLK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72671", "l": "eIF5B:GTP is hydrolyzed and released (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38950", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17919", "l": "[Glu(-Cys)](n+1)-Gly + glycine => [Glu(-Cys)](n)-Gly + glutathione + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28548", "l": "D-fructose => D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23312", "l": "2 sucrose = 1(F)-beta-D-fructosylsucrose + D-glucose"}, {"i": "EC:2.4.1.99", "l": "\"Sucrose:sucrose fructosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37703", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690669", "l": "CD22 binds itself to form homo-oligomers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070677", "l": "rRNA (cytosine-2'-O-)-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186765", "l": "PLC-gamma binds to the active receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30924", "l": "(R)-glycerate + ADP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58657", "l": "a 5'-(5'-phospho)-ribonucleoside-RNA + S-adenosyl-L-methionine => a 5'-(5'-phosphomethyl)-ribonucleoside-RNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36400", "l": "5alpha-cholest-8-en-3beta-ol + NADP(+) => 5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46692", "l": "4-hydroxybenzoate + ATP + H(+) = 4-hydroxybenzoyl-5'-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043905", "l": "Ser-tRNA(Thr) hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12815", "l": "D-glutamate => L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64288", "l": "2 nataloe emodin + O2 + reduced [NADPH--hemoprotein reductase] = cladofulvin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418925", "l": "ADORA2A,B bind Ade-Rib (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49891", "l": "(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2 <=> (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54142", "l": "5-methylcytidine(49) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine => cytidine(49) in tRNA precursor + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28905", "l": "D-alanine(out) + H(+)(out) => D-alanine(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20020", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2 <=> 5,10-methylenetetrahydromethanopterin + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373889", "l": "lactate + H+ [cytosol] <=> lactate + H+ [extracellular] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047912", "l": "galacturonokinase activity"}, {"i": "MetaCyc:GALACTURONOKINASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62854", "l": "GDP + H(+) + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467716", "l": "AGRN binds Alpha-dystroglycan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222690", "l": "DlaT reactivates AhpD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29907", "l": "H2O + sn-glycero-3-phospho-(1'-rac-glycerol) = glycerol + H(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111879", "l": "PIP2 hydrolysis (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102846", "l": "1-18:3-2-16:1-monogalactosyldiacylglycerol desaturase activity"}, {"i": "MetaCyc:RXN-8308"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204779", "l": "Interaction of Tie2 with Ang1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68611", "l": "Formation of ORC(1-5) complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52822", "l": "CoA + O-succinyl-L-serine => L-serine + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140769", "l": "factor VII -> factor VIIa (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418925", "l": "ADORA2A,B bind Ade-Rib (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60732", "l": "H2O + NADP(+) + perillyl aldehyde = 2 H(+) + NADPH + perillate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37287", "l": "ATP + H2O + L-alanyl-L-leucine(out) = ADP + H(+) + L-alanyl-L-leucine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33819", "l": "3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate = 3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]pyruvate"}, {"i": "EC:5.3.3.19", "l": "\"3-((4R)-4-hydroxycyclohexa-1,5-dien-1-yl)-2-oxopropanoate isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64709", "l": "butan-1-ol + NADP(+) => butanal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.216", "l": "\"Asperlicin C monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41538", "l": "2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine => 2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001874", "l": "(1->3)-beta-D-glucan immune receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54166", "l": "a 5'-(N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17930", "l": "an N-acylsphing-4-enine + ATP => ADP + an N-acylsphing-4-enine 1-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58436", "l": "4-methylpentan-1-ol + NADP(+) = 4-methylpentanal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14550", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O => 2-oxopent-4-enoate + formate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19804", "l": "ATP + D-pantetheine 4'-phosphate + H(+) <=> 3'-dephospho-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17265", "l": "trans-aconitate = cis-aconitate"}, {"i": "EC:5.3.3.7", "l": "\"Aconitate Delta-isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.82", "l": "\"Putrescine--2-oxoglutarate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66262", "l": "AMP + H(+) + IC-asc-C7-CoA => CoA + IC-asc-C7-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41646", "l": "2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate => 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38424", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50755", "l": "2 naphthalene-1,2,4,8-tetrol + O2 <=> 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392752", "l": "Phosphorylation of L1 by CK-II (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44945", "l": "1-O-alkyl-3-acyl-sn-glycerol + H2O => 1-O-alkyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25290", "l": "ethanol + NAD(+) = acetaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34510", "l": "2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate <=> N,N-diacetyllegionaminate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49146", "l": "dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate => 2-oxoglutarate + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047106", "l": "4-hydroxyphenylacetaldehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250217", "l": "ARL2:GTP binds ARL2BP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51331", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> 10-hydroperoxy-(8Z,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44621", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphinganine => a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062241", "l": "double strand break-nuclear membrane anchor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8979071", "l": "KDM6B binds iron (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63488", "l": "9,10-phenanthroquinone + H(+) + NADPH = NADP(+) + phenanthrene-9,10-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618486", "l": "miR-26 binds to the 3'UTR of the ABCA1 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35347", "l": "3-hydroxyoctadecanoyl-CoA = (2E)-octadecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5618331", "l": "HDAC6 deacetylates microtubules (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16119", "l": "acetoacetyl-CoA + AMP + diphosphate => acetoacetate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725315", "l": "ALK-stimulated MYCN gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "79.682896251205548", "identifiers": [{"i": "GO:1901474", "l": "azole transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72095", "l": "Internal Methylation of mRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.68", "l": "\"Coniferyl-aldehyde dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60750", "l": "CoA + pyrethrin II => (1R,3R)-pyrethroyl-CoA + (Z,S)-pyrethrolone"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050289", "l": "spermidine dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428273", "l": "SPHK1 phosphorylates SPG to S1P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32785", "l": "ADP + glycine betaine(in) + H(+) + phosphate => ATP + glycine betaine(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64772", "l": "S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine = 2-aminoprop-2-enoate + 2-methyl-3-sulfanylbutan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23310", "l": "2-O-[(E)-sinapoyl]-D-glucarate + CoA => (E)-sinapoyl-CoA + D-glucarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9613497", "l": "Unwinding DNA for the nascent transcript (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52848", "l": "5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine = 5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351936", "l": "Caspase-mediated cleavage of claspin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34212", "l": "ecgonine methyl ester + NADP(+) => ecgonone methyl ester + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17548", "l": "[peroxiredoxin]-S-hydroxy-S-oxy-L-cysteine + [protein]-dithiol + ATP <=> [peroxiredoxin]-S-hydroxy-L-cysteine + [protein]-disulfide + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53716", "l": "H(+) + N-acetyl-alpha-D-muramate 1-phosphate + UDP = phosphate + UDP-N-acetyl-alpha-D-muramate"}, {"i": "EC:2.7.7.99", "l": "\"N-acetyl-alpha-D-muramate 1-phosphate uridylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420274", "l": "GIP receptor binds gastric inhibitory peptide (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913371", "l": "GM-CSF receptor alpha:GM-CSF binds Bc (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044875", "l": "gamma-glutamyl hercynylcysteine sulfoxide synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983876", "l": "STAT4 binds IL12RB2:IL12RB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21009", "l": "diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+) => diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183122", "l": "Factor D cleaves C3b-bound Factor B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264615", "l": "Loading of acetylcholine in synaptic vesicles (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59687", "l": "D-maltohexaose + O2 <=> D-maltohexaono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167637", "l": "Internalization of Nef:CD28:Clathrin-Coated Pit Adapter Protein Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48096", "l": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.319", "l": "\"Type I protein arginine methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65858", "l": "a steroid 1,3-dione + AH2 => A + a 1-hydroxy-3-oxo steroid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56649", "l": "3-oxochol-4-en-24-oyl-CoA + NAD(+) => 3-oxochol-4,6-dien-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9652264", "l": "ERBB2 binds TKIs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34178", "l": "2-hydroxybenzoyl-CoA + malonyl-CoA <=> 4-hydroxycoumarin + CO2 + 2 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60207", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031697", "l": "beta-1 adrenergic receptor binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044750", "l": "high-affinity nickel cation transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102281", "l": "formylaminopyrimidine deformylase activity"}, {"i": "MetaCyc:RXN-12612"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853801", "l": "PSPN binds RET:GFRA4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34652", "l": "3-methyl-1,2-didehydro-2,3-dihydrosqualene + S-adenosyl-L-methionine => 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869683", "l": "oxPL binds LBP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019780", "l": "FAT10 activating enzyme activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0019972", "l": "interleukin-12 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419166", "l": "GEFs activate RhoA,B,C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1254291", "l": "ERBB4s80 binds STAT5A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102668", "l": "liquiritigenin,NADPH:oxygen oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004153", "l": "dihydropterin deaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196857", "l": "PANK2 phosphorylates PanK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687097", "l": "p-S857 NCOA3 binds ETV4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983158", "l": "Trimming of peptides in ER (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015093", "l": "ferrous iron transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31125", "l": "(4,5-dihydro-5-oxofuran-2-yl)-acetate => muconolactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44409", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O => a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42702", "l": "6-carboxyhexanoyl-[ACP] + H(+) + methanol => 6-carboxyhexanoyl-[ACP] methyl ester + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669012", "l": "EDA binds EDAR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44529", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113454", "l": "RNA Polymerase III Termination and release of transcribed RNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50802", "l": "prostaglandin A2-S-(S)-glutathione => glutathione + prostaglandin A2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61835", "l": "(24R)-ethylcholest-5-en-3beta-ol + UDP-alpha-D-glucose <=> H(+) + sitosteryl 3-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199014", "l": "CD96 binds PVR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74716", "l": "Insulin binds the insulin receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21385", "l": "L-phenylalanine => (E)-cinnamate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27879", "l": "2',3'-cyclic UMP + H2O => 3'-UMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48683", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) <=> a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050468", "l": "reticuline oxidase activity"}, {"i": "RHEA:19885", "l": "(S)-reticuline + O2 = (S)-scoulerine + H(+) + H2O2"}, {"i": "EC:1.21.3.3", "l": "\"Reticuline oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50907", "l": "L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9669893", "l": "KIT binds type I TKIs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69074", "l": "Formation of Processive Complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36017", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102625", "l": "cirsimaritin 4'-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-15530"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5140741", "l": "WNT5A binds FZD and ROR receptors (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855201", "l": "I(1,3,4,6)P4 transports from the cytosol to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66439", "l": "NADP(+) + pentan-3-one <=> H(+) + NADPH + pent-1-en-3-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15682", "l": "2-hydroxy-5-carboxymethylmuconate semialdehyde + H2O + NAD(+) => (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160851", "l": "HAS1,2,3 mediate the polymerisation of HA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63825", "l": "2 3-(4-hydroxyphenyl)pyruvate => aspulvinone E + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17763", "l": "an aromatic aldehyde + H(+) + NADPH => an aromatic primary alcohol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29995", "l": "ATP + H2O + putrescine(out) = ADP + H(+) + phosphate + putrescine(in)"}, {"i": "EC:7.6.2.16", "l": "\"ABC-type putrescine transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37220", "l": "A + D-valine + H2O => 3-methyl-2-oxobutanoate + AH2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061547", "l": "glycogen synthase activity, transferring glucose-1-phosphate"}, {"i": "REACT:R-HSA-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Homo sapiens)"}, {"i": "REACT:R-HSA-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17208", "l": "3'-phosphoadenylyl sulfate + quercetin 3-sulfate <=> adenosine 3',5'-bisphosphate + H(+) + quercetin 3,4'-bissulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3782637", "l": "HDAC8 deacetylates histones (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848023", "l": "Activated PTK6 binds STAP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694287", "l": "Cleavage of S protein into S1:S2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41311", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl (5Z,8Z,10E,12R,14Z)-hydroperoxyiecosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114553", "l": "Activation of conventional Protein Kinase C (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031818", "l": "P2Y9 nucleotide receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467436", "l": "AGRN binds Integrins alphaVbeta1 (Other beta1-containing integrins) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621116", "l": "FOXO1,FOXO3 bind CITED2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60921", "l": "2-oxoglutarate + an N(3)-methylcytidine in mRNA + O2 => a cytidine in mRNA + CO2 + formaldehyde + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013147", "l": "RAC1 GDIs block activation of RAC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46939", "l": "(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) <=> ATP + H(+) + L-2-aminoadipate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47363", "l": "decanoate ester + H2O <=> an aliphatic alcohol + decanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32440", "l": "(+)-epi-isozizaene + 2 H(+) + 2 NADPH + 2 O2 => albaflavenone + 3 H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64707", "l": "diphenylmethanol + NAD(+) <=> benzophenone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65443", "l": "a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidyl-adenosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidyl-adenosine in mRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15186", "l": "L-arginine + succinyl-CoA => CoA + H(+) + N(2)-succinyl-L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24664", "l": "2 N(omega)-hydroxy-L-arginine + NADPH + 2 O2 = H(+) + 2 H2O + 2 L-citrulline + NADP(+) + 2 nitric oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28150", "l": "acetyl-CoA + spermidine = CoA + H(+) + N(1)-acetylspermidine"}, {"i": "EC:2.3.1.57", "l": "\"Diamine N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036310", "l": "ATP-dependent DNA/DNA annealing activity"}, {"i": "REACT:R-HSA-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12494", "l": "D-methionine => L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8963915", "l": "1,25(OH)2D binds VDR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672978", "l": "RAF phosphorylates MAP2K dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32040", "l": "H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate => AMP + ATP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.119"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47398", "l": "an aliphatic alcohol + H(+) + octadecanoate => H2O + octadecanoate ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22489", "l": "S-(hydroxymethyl)glutathione => formaldehyde + glutathione"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018565", "l": "dihydroxydibenzothiophene dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16378", "l": "(3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin] => biliverdin IXalpha + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46416", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (6Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.19.26", "l": "\"Acyl-[acyl-carrier-protein] 6-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71164", "l": "homogentisate + O2 => maleylacetoacetate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33556", "l": "an N-acyl-(4R)-4-hydroxysphinganine + H2O => (4R)-hydroxysphinganine + a fatty acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047212", "l": "2-coumarate O-beta-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12014", "l": "ADP + H(+) + thiamine phosphate => ATP + thiamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49555", "l": "H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] <=> H(+) + L-lysyl-[protein] + lactate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051912", "l": "CoB--CoM heterodisulfide reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57418", "l": "L-aspartyl-[protein] + NH4(+) => H2O + L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58091", "l": "1-(7Z,10Z,13Z,16Z-docosatetraenoyl)-glycerol + H2O <=> (7Z,10Z,13Z,16Z)-docosatetraenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166082", "l": "IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32917", "l": "sn-glycero-3-phospho-1D-myo-inositol(in) => sn-glycero-3-phospho-1D-myo-inositol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1861788", "l": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177284", "l": "PKA phosphorylates PDE4B (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21298", "l": "D-galactono-1,4-lactone + H(+) + NADH => D-galactose + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36247", "l": "S-adenosyl-L-methionine + trans-anol = H(+) + S-adenosyl-L-homocysteine + trans-anethole"}, {"i": "EC:2.1.1.279", "l": "\"Trans-anol O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49742", "l": "CO2 + deoxyviolacein + 2 H2O + NADP(+) => 2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62809", "l": "H(+) + 2 julichrome Q6 + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + julichrome Q6-6 + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45608", "l": "H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59080", "l": "bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose = 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53016", "l": "chlorohydroquinone + 2 glutathione = chloride + glutathione disulfide + H(+) + hydroquinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48483", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + UDP-alpha-D-galactose <=> 1,2-di-(9Z-octadecenoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20470", "l": "H2O + IMP => D-ribose 5-phosphate + hypoxanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061667", "l": "URM1 ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139895", "l": "tBID activates BAK protein (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50798", "l": "prostaglandin A2-S-(R)-glutathione => glutathione + prostaglandin A2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35855", "l": "1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11710", "l": "H(+) + NADH + XMP => H2O + IMP + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730872", "l": "Activation of Calcineurin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1454928", "l": "ABCG4 may mediate cholesterol efflux (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159795", "l": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0008174", "l": "mRNA methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57248", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-dGTP = dGTP + glycolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62760", "l": "4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607750", "l": "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018774", "l": "RHOBTB1 binds GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004382", "l": "guanosine-diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29582", "l": "Fe(2+)(in) + H(+)(in) <=> Fe(2+)(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12502", "l": "3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH => NADP(+) + thiomorpholine-3-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.12", "l": "\"Xaa-Xaa-Pro tripeptidyl-peptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871226", "l": "RET binds GFRA1,GFRA2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54363", "l": "4-methyl-2-oxopentanoate + H(+) <=> 3-methylbutanal + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74059", "l": "PDE6 hydrolyses cGMP to GMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602473", "l": "Autocatalytic activation of MMP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106029", "l": "tRNA pseudouridine synthase activity"}, {"i": "RHEA:42564", "l": "uridine(38/39) in tRNA = pseudouridine(38/39) in tRNA"}, {"i": "EC:5.4.99.45", "l": "\"tRNA pseudouridine(38/39) synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30516", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => H(+) + S-methyl-5'-thioadenosine + thermospermine"}]}
{"type": "biolink:MolecularActivity", "ic": "73.539748874002555", "identifiers": [{"i": "GO:0015149", "l": "hexose transmembrane transporter activity"}, {"i": "REACT:R-HSA-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Homo sapiens)"}, {"i": "REACT:R-HSA-5638222", "l": "Defective SLC2A2 does not transport Fru, Gal, Glc from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5220959", "l": "TDG excises 5-formylcytosine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32570", "l": "(2E)-geranyl diphosphate <=> (1R,4S)-camphene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53345", "l": "5,6-dihydrouridine(20a) in tRNA + NADP(+) => H(+) + NADPH + uridine(20a) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57070", "l": "3-oxoisoapionate 4-phosphate + ADP + H(+) => 3-oxoisoapionate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25705", "l": "N-hydroxy-L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39659", "l": "3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15463", "l": "3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391933", "l": "EP3 receptor can bind PGE2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45862", "l": "4-hydroxy-6-(11-hydroxyheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA => 12-hydroxyoctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200406", "l": "CPT1A,B transfers PALM to CAR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36120", "l": "gibberellin A9 + S-adenosyl-L-methionine => O-methyl gibberellin A9 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2299620", "l": "Collagen XI cross-links with collagen II (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14164", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 <=> 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4093332", "l": "p-EPHB phosphorylates SDC2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35376", "l": "(beta-L-Ara4N)2-(Kdo)2-lipid A(in) + ATP + H2O => (beta-L-Ara4N)2-(Kdo)2-lipid A(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033968", "l": "glutaryl-7-aminocephalosporanic-acid acylase activity"}, {"i": "RHEA:23508", "l": "(7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate"}, {"i": "EC:3.5.1.93", "l": "\"Glutaryl-7-aminocephalosporanic-acid acylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24904", "l": "5'-phosphoguanylyl(3'->5')guanosine + H(+) => cyclic di-3',5'-guanylate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031857", "l": "type 1 parathyroid hormone receptor binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032551", "l": "pyrimidine ribonucleoside binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-873918", "l": "Transphosphorylation of JAK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40759", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoylglycerone 3-phosphate = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerone 3-phosphate + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-990526", "l": "Recruitment of AIP4 and K48 ubiquitination of MAVS/IPS-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58223", "l": "L-lysyl-[protein] + NAD(+) <=> H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047313", "l": "aromatic-amino-acid-glyoxylate transaminase activity"}, {"i": "MetaCyc:2.6.1.60-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183055", "l": "Binding of CBL to EGFR (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660828", "l": "ADORA2B:Ade-Rib binds heterometric G-protein Gs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51481", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20846", "l": "ADP + H(+) + oxaloacetate + phosphate => ATP + hydrogencarbonate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48022", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + D-galactose => globoside Gb3Cer + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2219524", "l": "PDPK1 binds PIP2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17056", "l": "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate <=> beta-D-fructose 6-phosphate + D-erythrose 4-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58749", "l": "desmethylnectriapyrone + S-adenosyl-L-methionine => H(+) + nectriapyrone + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64446", "l": "2 H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-homocysteine => L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25778", "l": "scyllo-inosine => scyllo-inosose"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0016819", "l": "hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides"}, {"i": "EC:3.6.2.-", "l": "\"In sulfonyl-containing anhydrides\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66591", "l": "a cytidine in 26S rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in 26S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31541", "l": "(2S)-sakuranetin + H(+) + S-adenosyl-L-homocysteine => (2S)-naringenin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36252", "l": "(E)-ferulate + ATP + CoA => (E)-feruloyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45597", "l": "H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869580", "l": "DEK binds TFAP2A homodimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22470", "l": "2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate => GTP + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65502", "l": "5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + A + H(+) + L-methionine => [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + AH2 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863472", "l": "DAB2 binds LRP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12622", "l": "H(+) + L-aspartate => CO2 + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692880", "l": "HRH3 binds Hist (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15329", "l": "(S)-ureidoglycolate + NAD(+) = H(+) + N-carbamoyl-2-oxoglycine + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0016827", "l": "hydrolase activity, acting on acid carbon-phosphorus bonds"}, {"i": "EC:3.11.-.-", "l": "\"Acting on carbon-phosphorus bonds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34885", "l": "ADP + H(+) + phosphate + selenate(in) => ATP + H2O + selenate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5626938", "l": "Beta-catenin binds SOX proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2562526", "l": "PLK1 phosphorylates OPTN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36162", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 oxidized 2[4Fe-4S]-[ferredoxin] <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322427", "l": "Beta-catenin recruits CBP/p300 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043715", "l": "2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54070", "l": "diphosphate + sesterfisherol => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656775", "l": "Cysmethynil binds ICMT:Zn2+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047521", "l": "3alpha,7alpha,12beta-trihydroxy-5beta-cholanate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389381", "l": "Gads binds CD28 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382057", "l": "Release of novel PDGFs as latent factors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65797", "l": "fenuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163669", "l": "Transcriptional activation of pyruvate kinase gene by ChREBP:MLX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26418", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 = (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186786", "l": "Autophosphorylation of PDGF beta receptors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20280", "l": "acetyl-CoA + an N-hydroxyarylamine <=> an N-acetoxyarylamine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043714", "l": "(R)-citramalate synthase activity"}, {"i": "RHEA:19045", "l": "acetyl-CoA + H2O + pyruvate = (3R)-citramalate + CoA + H(+)"}, {"i": "EC:2.3.1.182", "l": "\"(R)-citramalate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18912", "l": "2,4,6-trichlorophenol + S-adenosyl-L-methionine <=> 2,4,6-trichloroanisole + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54849", "l": "H(+) + hexan-3-one + NADPH + O2 => H2O + NADP(+) + propyl propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25177", "l": "4-methyl-2-oxopentanoate + CoA + NAD(+) = 3-methylbutanoyl-CoA + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9659380", "l": "Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879930", "l": "STAT5 is recruited by JAK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5246478", "l": "APOM binds retinoids (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14021", "l": "AH2 + ecdysone + O2 = 20-hydroxyecdysone + A + H2O"}, {"i": "EC:1.14.99.22", "l": "\"Ecdysone 20-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0032546", "l": "deoxyribonucleoside binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47380", "l": "(25R)-3beta-hydroxycholest-5-en-7-one-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxycholest-5-en-7-one-26-oate + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156930", "l": "GTP-binding activates eEF2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661432", "l": "BIL binds ALB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50174", "l": "N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24178", "l": "[ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] => [ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20866", "l": "beta-D-glucose 1-phosphate + D-glucose 6-phosphate => alpha,alpha-trehalose 6-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.79"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798528", "l": "S100A8:S100A9 binds Mn2+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031267", "l": "small GTPase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65412", "l": "dAMP(in) + NAD(+)(out) = dAMP(out) + NAD(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225952", "l": "Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031835", "l": "substance P receptor binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000831", "l": "inositol hexakisphosphate 6-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27683", "l": "ATP + dTDP => ADP + dTTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12001", "l": "formate + NADP(+) => CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14375", "l": "(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin] => 5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018774", "l": "RHOBTB1 binds GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008822", "l": "PPM1D dephosphorylates RUNX2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56128", "l": "A + dimethylallyl diphosphate + H2O + nonaflavuxanthin = AH2 + diphosphate + flavuxanthin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42943", "l": "cytidine(34) in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005502", "l": "11-cis retinal binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41373", "l": "1-O-dodecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-dodecyl-sn-glycero-3-phosphocholine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5622134", "l": "CRABP1 binds atRA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48072", "l": "ganglioside GM1 (d18:1(4E)) + H2O = ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-874087", "l": "SGT1 binds HSP90 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018572", "l": "3,5-dichlorocatechol 1,2-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-741386", "l": "RIP2 induces K63-linked ubiquitination of NEMO (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9692809", "l": "CDC42 binds effectors at the ER membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25328", "l": "N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine <=> H(+) + phosphocholine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34588", "l": "2-oxoglutarate + O2 + pentalenolactone E => CO2 + pentalenolactone F + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25550", "l": "abieta-8(14),12-diene + diphosphate => (+)-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37063", "l": "2-thio-N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48467", "l": "ganglioside GM1b + H2O <=> ganglioside GA1 + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55817", "l": "a bacteriochlorophyllide d + H2O + S-adenosyl-L-methionine => 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide d + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25605", "l": "2-(5-methylsulfanyl)oxopentanoate + acetyl-CoA + H2O = 2-(3-methylsulfanyl)propylmalate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27588", "l": "indole-3-pyruvate + L-alanine => L-tryptophan + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4608855", "l": "PRICKLE1 is degraded by the proteasome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55578", "l": "H(+) + psilocybin + S-adenosyl-L-homocysteine => 4-hydroxy-N-methyltryptamine 4-phosphate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53487", "l": "androst-4-ene-3,11,17-trione + H(+) + NADPH <=> 17beta-hydroxyandrost-4-ene-3,11-dione + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25067", "l": "(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) => (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44097", "l": "decan-1-ol + hexadecanoyl-CoA => CoA + decanyl hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24229", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+) => 4-methylcatechol + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102781", "l": "isofucosterol hydroxylase activity"}, {"i": "MetaCyc:RXN-7877"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266303", "l": "Spherical HDL binds C and E apolipoproteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086204", "l": "IBSP binds collagen type I (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036434", "l": "nitronate monooxygenase (FMN-linked) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25035", "l": "all-trans-retinal + H(+) + NADPH => all-trans-retinol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24041", "l": "NADPH + 2 oxidized [cytochrome P450] => H(+) + NADP(+) + 2 reduced [cytochrome P450]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015272", "l": "ATP-activated inward rectifier potassium channel activity"}, {"i": "REACT:R-HSA-5683209", "l": "Activating ABCC8 mutants cause hyperglycemia in permanent neonatal diabetes mellitus (PNDM) and transient neonatal DM (TNDM). (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51459", "l": "H2O + N-(9Z-octadecenoyl)-L-isoleucine <=> (9Z)-octadecenoate + L-isoleucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605797", "l": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15723", "l": "glyoxylate + H(+) + NADH + NH4(+) => glycine + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687107", "l": "MAPK4,6 translocate to nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917730", "l": "Cargo Recognition And Sorting (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20431", "l": "acacetin + H(+) + S-adenosyl-L-homocysteine => apigenin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134953", "l": "DHX36 or DHX9 binds MyD88 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45220", "l": "[methyl-Co(III) trimethylamine-specific corrinoid protein] + coenzyme M = [Co(I) trimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50395", "l": "H(+) + oxidized coenzyme F420-(gamma-Glu)(n) + oxytetracycline <=> 5a,11a-dehydrooxytetracycline + reduced coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37128", "l": "2-oxoglutarate + dioxidophosphate + H2O2 => CO2 + H(+) + phosphonate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37874", "l": "2-heptyl-4(1H)-quinolone + H(+) + NADH + O2 <=> 2-heptyl-3-hydroxy-4(1H)-quinolone + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875816", "l": "STAT3 binds activated MET receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46427", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015594", "l": "ABC-type putrescine transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44550", "l": "an (omega-1)-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43850", "l": "[thioredoxin]-disulfide + arsenite + H2O => [thioredoxin]-dithiol + arsenate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49518", "l": "adenosine in mRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + N(1)-methyladenosine in mRNA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45916", "l": "12-hydroxyoctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(13-hydroxy-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55178", "l": "2-hydroxybutanoyl-CoA + CO2 + succinate => 2-oxoglutarate + butanoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013157", "l": "CDC42 binds effectors at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43633", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) => an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1638845", "l": "CERK phosphorylates CERA to form C1P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46628", "l": "3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH = androst-5-en-3beta,17beta-diol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15249", "l": "3,4,5-trihydroxybenzoate + UDP-alpha-D-glucose = 1-O-galloyl-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36545", "l": "1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate => H2O + mycothiol S-conjugate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59346", "l": "D-maltobiono-1,5-lactone + H2O2 => D-maltose + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45118", "l": "H(+) + ipsdienone + NADPH => (4R)-ipsdienol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43430", "l": "1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1,2-didecanoyl-sn-glycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-997237", "l": "SH2B proteins bind JAK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48694", "l": "H(+) + octanoate + octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => 1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31550", "l": "2 (2E,6E)-farnesyl diphosphate <=> 15-cis-4,4'-diapophytoene + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981093", "l": "IL12 bound to IL12R internalises (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "78.047734625335977", "identifiers": [{"i": "GO:0140299", "l": "small molecule sensor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047432", "l": "2,2-dialkylglycine decarboxylase (pyruvate) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73945", "l": "FAS-mediated dimerization of procaspase-8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35299", "l": "3-hydroxyoctadecanoyl-CoA + NADP(+) = 3-oxooctadecanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45543", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23573", "l": "3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 3 CO2 + 4 CoA + phlorisovalerophenone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49129", "l": "AH2 + N-acetyl-demethyl-L-phosphinothricin + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + A + 2 H(+) + L-methionine + N-acetyl-L-phosphinothricin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174446", "l": "Removal of remaining Flap from the C-strand (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58782", "l": "a 5'-methyltriphosphate-guanosine-ribonucleotide-snRNA + S-adenosyl-L-homocysteine => a 5'-triphospho-guanosine-ribonucleotide-snRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605724", "l": "Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43615", "l": "S-adenosyl-L-methionine + uridine(341) in tmRNA <=> 5-methyluridine(341) in tmRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "74.603620314006946", "identifiers": [{"i": "GO:0019199", "l": "transmembrane receptor protein kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39218", "l": "(2E)-hexacosenoyl-CoA + H(+) + NADPH <=> hexacosanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41306", "l": "H2O + N-dodecanoyl-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + dodecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63704", "l": "mycophenolate + UDP-alpha-D-glucuronate = H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0016682", "l": "oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor"}, {"i": "EC:1.10.3.-", "l": "\"With oxygen as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698408", "l": "PTPRJ dephosphorylates active FLT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15323", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (6aR,11aR)-3,9-dihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59752", "l": "L-lysyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N(6)-tetradecanoyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43718", "l": "[glutamine synthetase]-L-tyrosine + ADP => [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453342", "l": "PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54399", "l": "1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19207", "l": "diphosphate + dUMP + NH4(+) => dCTP + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015120", "l": "phosphoglycerate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38051", "l": "2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA = 1-butyryl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39260", "l": "(3R)-hydroxy-(13Z)-docosenoyl-CoA => (2E,13Z)-docosadienoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050272", "l": "S-carboxymethylcysteine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102894", "l": "UDPG:cyclo-DOPA 5-O-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-8481"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174551", "l": "Formation of alternative pathway C5 convertase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39769", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0016867", "l": "intramolecular transferase activity, transferring acyl groups"}, {"i": "EC:5.4.1.-", "l": "\"Transferring acyl groups\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140629", "l": "small conductance calcium-activated potassium channel inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.7", "l": "\"Ferric-chelate reductase (NADH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45021", "l": "L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20305", "l": "4-hydroxybenzaldehyde + H2O + NAD(+) = 4-hydroxybenzoate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.64", "l": "\"4-hydroxybenzaldehyde dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798528", "l": "S100A8:S100A9 binds Mn2+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005304", "l": "L-valine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45438", "l": "H(+) + N-hexadecanoylethanolamine + sn-glycerol 3-phosphate => H2O + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11076", "l": "anthranilate + 3 H(+) + NADH + O2 = catechol + CO2 + NAD(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33140", "l": "L-alanine(out) + L-aspartate(in) => L-alanine(in) + L-aspartate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357429", "l": "AXL autophosphorylates on Y772 and Y814 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592362", "l": "Activation of proMMP7 by MMP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034855", "l": "4-AD 9alpha-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004310", "l": "farnesyl-diphosphate farnesyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59147", "l": "10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide <=> 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211193", "l": "Homodimerization  of DFF40 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862700", "l": "CMKLR1 binds Resolvin E1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030620", "l": "U2 snRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.72"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017172", "l": "cysteine dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0015140", "l": "malate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55324", "l": "11-cis-retinol + hexadecanoyl-CoA = 11-cis-retinyl hexadecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4093327", "l": "EPHA binds TIAM1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53081", "l": "4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate => 4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64280", "l": "(S)-1-phenylethylamine + pyruvate = acetophenone + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57283", "l": "a guanosine in RNA + glyoxal <=> an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52059", "l": "12-hexadecanoyloxy-octadecanoate + H2O <=> 12-hydroxyoctadecanoate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008753", "l": "NADPH dehydrogenase (quinone) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855217", "l": "I(1,4,5)P3 transports from the ER lumen to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18903", "l": "benzyl alcohol + CO2 + L-leucine => H(+) + H2O + N-benzyloxycarbonyl-L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784204", "l": "JAKs bind OSMR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.30", "l": "\"NAD(+) ADP-ribosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30674", "l": "H2O + N,N'-diacetylchitobiose <=> 2 N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45166", "l": "2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45468", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa-cis-undecaprenyl diphosphate = (Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate"}, {"i": "EC:2.7.4.29", "l": "\"Kdo(2)-lipid A phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5671993", "l": "CIT-3 binds DLG4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627056", "l": "Procaspase 9 forms dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59551", "l": "N,N',N''-triacetylchitotriose + O2 <=> H2O2 + N,N',N''-triacetylchitotriono-1,5-lactone"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004830", "l": "tryptophan-tRNA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43616", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate"}, {"i": "EC:2.7.7.80", "l": "\"Molybdopterin-synthase adenylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39848", "l": "a 2-acylglycerol + ATP => a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29744", "l": "2-phenylethylamine(in) => 2-phenylethylamine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27403", "l": "(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate => 2-hydroxychromene-2-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64831", "l": "3-hydroxybenzyl alcohol + acetyl-CoA <=> 3-hydroxy-benzyl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10497", "l": "L-arginyl-[myelin basic protein] + S-adenosyl-L-methionine => H(+) + N(omega)-methyl-L-arginyl-[myelin basic protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65683", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontenoyl)-sphing-4-enine <=> a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20641", "l": "H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH"}, {"i": "EC:1.1.1.23", "l": "\"Histidinol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63779", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine <=> 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103031", "l": "L-Ala-D/L-Glu epimerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67136", "l": "3-hydroxypropanoate + ATP + CoA = 3-hydroxypropanoyl-CoA + ADP + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035244", "l": "peptidyl-arginine C-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64344", "l": "4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + H(+) + NADPH + O2 = 2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047006", "l": "17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009936", "l": "RNASEL cleaves cellular ssRNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032067", "l": "NTRK2 activates RAS signaling through FRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41600", "l": "1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9007926", "l": "ATRX binds DAXX (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70486", "l": "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10348", "l": "5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate"}, {"i": "EC:3.5.2.9", "l": "\"5-oxoprolinase (ATP-hydrolyzing)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050618", "l": "phycoerythrobilin:ferredoxin oxidoreductase activity"}, {"i": "RHEA:22092", "l": "(3Z)-phycoerythrobilin + oxidized 2[4Fe-4S]-[ferredoxin] = 15,16-dihydrobiliverdin + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]"}, {"i": "EC:1.3.7.3", "l": "\"Phycoerythrobilin:ferredoxin oxidoreductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43924", "l": "NAD(+) + pregnenolone = H(+) + NADH + pregn-5-ene-3,20-dione"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035240", "l": "dopamine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34640", "l": "1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 => H2O + NADP(+) + neopentalenolactone D"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102134", "l": "(22S)-22-hydroxy-campesterol C-23 hydroxylase activity"}, {"i": "MetaCyc:RXN-11529"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209910", "l": "Iodide is taken up by thyroid epithelial cells (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25978", "l": "(5S)-albaflavenol + H2O + NADP(+) => (+)-epi-isozizaene + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29366", "l": "dCMP + H2O <=> 2'-deoxycytidine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134896", "l": "LRR FLII-interacting protein 1 binds dsDNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15952", "l": "(R)-2-hydroxyoctadecanoate + NAD(+) <=> 2-oxodecanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45023", "l": "L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5660660", "l": "p300 acetylates RELA subunit (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54753", "l": "methanophenazine + reduced coenzyme F420-(gamma-Glu)(n) => dihydromethanophenazine + H(+) + oxidized coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.19", "l": "\"Procollagen C-endopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30524", "l": "GTP + L-glutamate + oxidized coenzyme F420-1 => GDP + H(+) + oxidized coenzyme F420-2 + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683712", "l": "3a translocates to the ERGIC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5627775", "l": "Autophosphorylation of PAK1,2,3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46506", "l": "AMP + dodecanoyl-[ACP] + H(+) => dodecanoyl-AMP + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675947", "l": "TNFSF18 binds TNFRSF18 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9659820", "l": "RB1 translocates to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58466", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + H(+) + UDP => a neolactoside nLc4Cer + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2172666", "l": "RB1 binds condensin II (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109822", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033550", "l": "MAP kinase tyrosine phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018659", "l": "4-hydroxybenzoate 3-monooxygenase activity"}, {"i": "EC:1.14.13.2", "l": "\"4-hydroxybenzoate 3-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250220", "l": "Homodimerization of ERBB4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047818", "l": "D-fuconate dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40645", "l": "(9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+) => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18568", "l": "19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine <=> 9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030604", "l": "1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"}, {"i": "KEGG.REACTION:R05688"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213201", "l": "Formation of collagen fibres (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63382", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + H(+) + phosphocholine => a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103028", "l": "murein hydrolase activity"}, {"i": "MetaCyc:RXN0-5190"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12802", "l": "ATP + L-seryl-[tau protein] => ADP + H(+) + O-phospho-L-seryl-[tau protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004635", "l": "phosphoribosyl-AMP cyclohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016295", "l": "myristoyl-[acyl-carrier-protein] hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421452", "l": "2 protoporphyrinogen IX + 3 O2 => 2 protoporphyrin IX + 6 H2O (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114552", "l": "Thrombin-activated PARs activate G12/13 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51718", "l": "AMP(in) + diphosphate(in) + H(+)(in) + hexadecanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + hexadecanoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57314", "l": "cytidine 5'-diphosphoramidate + H(+) + L-glutamate => H2O + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13610", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20730", "l": "2-oxoglutarate + H2O2 + NH4(+) => H2O + L-glutamate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62259", "l": "Cd(2+)(out) + 2 hydrogencarbonate(out) <=> Cd(2+)(in) + 2 hydrogencarbonate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052694", "l": "jasmonoyl-isoleucine-12-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685604", "l": "SLAMF6 binds SLAMF6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34851", "l": "(3S)-3-hydroxyadipyl-CoA + NAD(+) = 3-oxoadipyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928591", "l": "EPH:EFN tetramers oligomerise (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388811", "l": "CD28 homodimer binds B7-1 homodimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71783", "l": "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985799", "l": "SLIT1 binds ROBO1,(ROBO2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50481", "l": "acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28920", "l": "4-aminobutanoate(in) + L-glutamate(out) => 4-aminobutanoate(out) + L-glutamate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.1.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19104", "l": "2-butyne-1,4-diol + NAD(+) <=> 4-hydroxy-2-butynal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019168", "l": "2-octaprenylphenol hydroxylase activity"}, {"i": "RHEA:27790", "l": "2-all-trans-octaprenylphenol + H(+) + NADPH + O2 = 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP(+)"}, {"i": "MetaCyc:2-OCTAPRENYLPHENOL-HYDROX-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34892", "l": "selenite(in) => selenite(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45447", "l": "H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphoethanolamine <=> H(+) + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11642", "l": "an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADH => a (2R,3R)-flavan-3-ol + 2 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191825", "l": "Nuclear export of snRNA transcripts (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61266", "l": "H2O2 + NH4(+) + pyruvate => H2O + L-alanine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353455", "l": "Autophosphorylation of DNA-PKcs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865482", "l": "KMT2A (MLL) binds RUNX1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33664", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine + O2 => 2 [Fe(III)-cytochrome b5] + H2O + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42657", "l": "diphthine methyl ester-[translation elongation factor 2] + H2O => diphthine-[translation elongation factor 2] + H(+) + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49330", "l": "2-hydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spheroidene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.199"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45861", "l": "12-hydroxyoctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(11-hydroxyheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197564", "l": "NOTCH2 stimulates transcription of HES5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610720", "l": "PKA phosphorylates GLI3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16127", "l": "ADP + D-fructose 6-phosphate + H(+) => ATP + D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43406", "l": "H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP => N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350467", "l": "GUG binds to FT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24583", "l": "D-sorbitol 6-phosphate + H2O <=> D-sorbitol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63671", "l": "CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+) <=> (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20340", "l": "(R)-2-O-sulfolactate + H2O <=> (R)-lactate + H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373875", "l": "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43923", "l": "(25R)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25R)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70486", "l": "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47235", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA <=> (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42894", "l": "5'-deoxyinosine + NH4(+) => 5'-deoxyadenosine + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102490", "l": "8-oxo-dGTP phosphohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48985", "l": "(2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2 => 2,4-dichlorophenol + CO2 + glyoxylate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609738", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN2C (GRIN2C) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34225", "l": "2,6-dihydroxypseudooxynicotine + AH2 => 6-hydroxypseudooxynicotine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694436", "l": "MIA2 and MIA3 dissociate from procollagen VII vesicle (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035472", "l": "choriogonadotropin hormone receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917696", "l": "Cargo Sequestration (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42146", "l": "a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20733", "l": "[protein]-dithiol + [thioredoxin]-disulfide => [protein]-disulfide + [thioredoxin]-dithiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54050", "l": "4-epi-cubebol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14057", "l": "a 1,2-diacyl-sn-glycerol + a glycerophospholipid = a monoacylglycerophospholipid + a triacyl-sn-glycerol"}, {"i": "EC:2.3.1.158", "l": "\"Phospholipid:diacylglycerol acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58085", "l": "1-(13Z-docosenoyl)-glycerol + H2O => (13Z)-docosenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18500", "l": "L-ribulose 5-phosphate <=> L-xylulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20453", "l": "scopoletin + UDP-alpha-D-glucose = H(+) + scopolin + UDP"}, {"i": "EC:2.4.1.128", "l": "\"Scopoletin glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11366", "l": "AMP + 2 H(+) + phosphate + phosphoenolpyruvate => ATP + H2O + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12575", "l": "(R)-1-aminopropan-2-ol + adenosylcob(III)yrate + ATP <=> adenosylcob(III)inamide + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56787", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + (n-1) H2O <=> (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811431", "l": "RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433488", "l": "Phosphorylation of SHP2 by SFKs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44736", "l": "acetyl-CoA + dihydroxyacetone phosphate = 3-hydroxy-2,4-dioxopentyl phosphate + CoA"}, {"i": "EC:2.3.1.245", "l": "\"3-hydroxy-5-phosphooxypentane-2,4-dione thiolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40922", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047242", "l": "hydroxyanthraquinone glucosyltransferase activity"}, {"i": "MetaCyc:2.4.1.181-RXN"}, {"i": "EC:2.4.1.181", "l": "\"Hydroxyanthraquinone glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14116", "l": "(DNA)-3'-(deoxyribonucleoside 3',5'-bisphosphate) + H2O <=> (DNA)-3'-(deoxyribonucleoside 5'-phosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25502", "l": "diphosphate + terpinolene => (2E)-geranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17195", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12886", "l": "GDP-alpha-D-mannose + queuosine 5'-phosphate in tRNA(Asp) => beta-D-mannosyl-5''-O-queuosine 5'-phosphate in tRNA(Asp) + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.14", "l": "\"5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76426", "l": "N-atom dealkylation of caffeine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034820", "l": "4,9-DSHA hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10175", "l": "(3R)-hydroxybutanoate dimer + H2O <=> 2 (R)-3-hydroxybutanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24119", "l": "(2E)-geranyl diphosphate + H2O <=> (S)-linalool + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17575", "l": "H(+) + macrocin + S-adenosyl-L-homocysteine => demethylmacrocin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37270", "l": "H2O + L-alanyl-L-aspartate <=> L-alanine + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21082", "l": "diphosphate + phosphate + S-adenosyl-L-methionine => ATP + H2O + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879937", "l": "The common beta chain IL3RB binds JAK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0034185", "l": "apolipoprotein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56207", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] <=> 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050629", "l": "tetrachloroethene reductive dehalogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928641", "l": "PAK binds RAC and bPIX (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043337", "l": "CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678327", "l": "MIOX oxidises Ins to GlcA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086082", "l": "cell adhesive protein binding involved in AV node cell-bundle of His cell communication"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708497", "l": "BACH1 gene produces BACH1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50072", "l": "ATP + H2O + tauroursodeoxycholate(in) = ADP + H(+) + phosphate + tauroursodeoxycholate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3134954", "l": "DHX9 binds DNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37831", "l": "(S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 = 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11340", "l": "5-guanidino-2-oxopentanoate + H(+) = 4-guanidinobutanal + CO2"}, {"i": "EC:4.1.1.75", "l": "\"5-guanidino-2-oxopentanoate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.3.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373745", "l": "SDK1 homophillic interaction (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071906", "l": "CRD domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173725", "l": "C9 binds C5b:C6:C7:C8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47052", "l": "(2E,6E)-farnesyl diphosphate = alpha-selinene + diphosphate"}, {"i": "EC:4.2.3.198", "l": "\"Alpha-selinene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26232", "l": "3 NADP(+) + phytyl diphosphate <=> geranylgeranyl diphosphate + 3 H(+) + 3 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614605", "l": "Persulfide sulfur is dioxygenated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953336", "l": "Expression of EXTL1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012835", "l": "GDIs block activation of RHOA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42958", "l": "5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(38) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53097", "l": "4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine => 4-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12229", "l": "ATP + H2O + L-aspartate + L-glutamine => AMP + diphosphate + H(+) + L-asparagine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63081", "l": "AH2 + ATP + ilicicolinate B => A + AMP + diphosphate + ilicicolin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40468", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O => (9Z)-octadecenoate + 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56085", "l": "[Rab1 protein]-O-phosphocholine-L-serine + H2O => [Rab1 protein]-L-serine + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51240", "l": "(9Z,12Z)-octadecadienoate + O2 = (13R)-hydroperoxy-(9Z,11E)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40033", "l": "diphosphate + ent-manool => ent-copalyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106177", "l": "cyclic-GMP-AMP hydrolase activity"}, {"i": "RHEA:58808", "l": "2',3'-cGAMP + 2 H2O = AMP + GMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28818", "l": "4-hydroxybenzoate(in) + H(+)(out) <=> 4-hydroxybenzoate(out) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51180", "l": "cytidine(49) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(49) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57265", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP => GDP + glycolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1467269", "l": "Beta-defensins bind microbial membranes causing disruption (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70420", "l": "HK1,2,3,GCK phosphorylate Glc to form G6P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21265", "l": "A + glycolate => AH2 + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003947", "l": "(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662606", "l": "MT3 binds zinc (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55457", "l": "ferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + sugiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938815", "l": "RNF152 polyubiquitinates RRAGA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2981040", "l": "COLEC12:ligand is endocytosed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45264", "l": "(9Z,12Z)-octadecadienoate(out) = (9Z,12Z)-octadecadienoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23082", "l": "2-dehydro-3-deoxy-L-rhamnonate + H2O => L-rhamnonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9606887", "l": "p-CD19:VAV binds PI3K and GRB2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6805061", "l": "CK2 binds FACT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42913", "l": "cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14693", "l": "dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP"}, {"i": "EC:2.4.1.153", "l": "\"UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018609", "l": "chlorobenzene dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29038", "l": "ATP + H2O + L-glutamate(out) <=> ADP + H(+) + L-glutamate(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621573", "l": "CD209 activate GTPase RAS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22771", "l": "4-nitrophenyl-3-ketovalidamine <=> 4-nitroaniline + 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102919", "l": "5,6-dimethylbenzimidazole synthase activity"}, {"i": "RHEA:27345", "l": "FMNH2 + O2 = 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate + H(+)"}, {"i": "EC:1.13.11.79", "l": "\"Aerobic 5,6-dimethylbenzimidazole synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45485", "l": "H(+) + pyruvate => acetaldehyde + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31286", "l": "FAD + H(+) + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + FADH2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004592", "l": "pantoate-beta-alanine ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014812", "l": "ROBOs bind keratan sulfate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52975", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] <=> a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "81.790986234327661", "identifiers": [{"i": "GO:0015562", "l": "efflux transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39750", "l": "cholesterol(in) <=> cholesterol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685603", "l": "SAP and EAT2 binds SLAMF6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60638", "l": "choline + N-dodecanoyl-sphing-4-enine-1,3-cyclic phosphate => N-(dodecanoyl)-sphing-4-enine-1-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39839", "l": "a 2,3-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26184", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H2O = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33696", "l": "C20 sphinganine + NADP(+) => 3-oxoeicosasphinganine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805546", "l": "Keratin type I binds keratin type II (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13275", "l": "6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202692", "l": "PIP3 binds to RhoA and activates it (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63179", "l": "(2S)-ibuprofenoyl-CoA <=> (2R)-ibuprofenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805792", "l": "p-S291-PHF20 translocates to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.150", "l": "\"Lycopene elongase/hydratase (dihydrobisanhydrobacterioruberin-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40030", "l": "9alpha-copalyl diphosphate + H2O <=> (13S)-vitexifolin A + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196026", "l": "Dab2 is recruited to the junctional plaques (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1470011", "l": "Downregulation of c-Kit signaling by SOCS6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549424", "l": "Expression of CCRN4L (NOCTURNIN) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.4.-", "l": "\"Other carbon--nitrogen ligases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209221", "l": "Assembly of the PGN:PGRP-LC oligomer receptor 'signalling complex' (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33089", "l": "1,4-dihydroxy-6-naphthoate + chemical entity => cyclic dehypoxanthinylfutalosinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48256", "l": "(2S)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70613", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24602", "l": "H2O2 + sulfate => H2O + O2 + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088264", "l": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57730", "l": "CO2 + itaconate => H(+) + trans-aconitate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000277", "l": "[cytochrome c]-lysine N-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868230", "l": "SNX9 recruits components of the actin polymerizing machinery (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75096", "l": "Docking of the TAP:EJC Complex with the NPC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47587", "l": "ganglioside GT2 (d18:1(4E)) + UDP-alpha-D-galactose <=> ganglioside GT1c (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11171", "l": "3-hydroxy-6-carboxyhexanoyl-CoA + NAD(+) <=> 3-oxo-6-carboxyhexanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42316", "l": "a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.2.7.11", "l": "\"2-oxoacid oxidoreductase (ferredoxin)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018756", "l": "ammeline aminohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928625", "l": "PAKs autophosphorylate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48729", "l": "3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+) => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6795473", "l": "PDPK1 phosphorylates SGK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17571", "l": "1,2-dehydroreticuline + H(+) + NADPH => (R)-reticuline + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54229", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine => 2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102575", "l": "3-oxo-dodecanoyl-ACP hydrolase activity"}, {"i": "MetaCyc:RXN-15281"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66285", "l": "tomatidine + UDP-alpha-D-glucose => H(+) + tomatidine 3-O-beta-D-glucopyranoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22989", "l": "3-oxopropanoate + CoA + NADP(+) => acetyl-CoA + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.2.11", "l": "\"Cholesterol-5,6-oxide hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19087", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate => 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35783", "l": "neamine + UDP-alpha-D-kanosamine = H(+) + kanamycin B + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61360", "l": "ATP + H2O + pheophorbide a(in) = ADP + H(+) + pheophorbide a(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205238", "l": "SHP2 interacts with p-KIT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58332", "l": "(E)-non-2-en-1-ol + NADP(+) = (E)-non-2-enal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58163", "l": "ent-copalyl diphosphate <=> diphosphate + dolabradiene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63323", "l": "a glycerophospholipid(in) + ATP + H2O <=> a glycerophospholipid(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13722", "l": "H2O + testololactone => H(+) + testolate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28305", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + germacrene C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43188", "l": "S-adenosyl-L-methionine + uridine(2634) in 25S rRNA = H(+) + N(3)-methyluridine(2634) in 25S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800315", "l": "MST1 binds MST1R (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617828", "l": "TRIP11:IFT20 dissociates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424476", "l": "Activation of RAC1 by VAV2/3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66683", "l": "ATP + coproporphyrinogen III(in) + H2O <=> ADP + coproporphyrinogen III(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211476", "l": "HNF1A-dependent synthesis of GLUT2 protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046965", "l": "retinoid X receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5638004", "l": "RP2 binds ARL3:GTP:UNC119B (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43530", "l": "2-aminomalonate semialdehyde + H(+) + NADH => L-serine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693536", "l": "ATM phosphorylates MDC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60914", "l": "H(+) + N(3)-methylcytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-homocysteine => cytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45249", "l": "butanoate(out) => butanoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15054", "l": "(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide => (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863471", "l": "LDLR is bound by DAB2 and ARH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9706399", "l": "RHOBTB3 hydrolyzes ATP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033417", "l": "CUU codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374899", "l": "Release of noradrenaline  at the synapse (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34266", "l": "dimethylallyl diphosphate + fumigaclavine A <=> diphosphate + fumigaclavine C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33510", "l": "sphing-4-enine 1-phosphate <=> (2E)-hexadecenal + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32955", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685230", "l": "CHEK1 phosphorylates RAD51 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49860", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33252", "l": "2 sucrose => 6-kestotriose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42814", "l": "cholesteryl octadecanoate + CoA => cholesterol + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69299", "l": "CDT1 binds geminin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849085", "l": "ARHGAP35 binds RHOA:GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40352", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15543", "l": "DIMBOA beta-D-glucoside + H(+) + UDP => DIMBOA + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77068", "l": "Activation of GT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.30"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47428", "l": "(3S)-hydroxy-(9Z-octadecenoyl)-CoA + NAD(+) = 3-oxo-(9Z-octadecenoyl)-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54684", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (-)-kolavenyl diphosphate"}, {"i": "EC:5.5.1.28", "l": "\"(-)-kolavenyl diphosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676598", "l": "TRAF2:cIAP1/2 complex binds FN14:TWEAK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21437", "l": "[translation elongation factor 2] + ATP => [translation elongation factor 2]-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63453", "l": "3-[(R)-glyceryl]-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin => GMP + H(+) + oxidized 3PG-factor420-0"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42071", "l": "(3R,5R)-clavulanate-9-aldehyde + H(+) + NADPH <=> clavulanate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8987007", "l": "p-STAT1 dimerizes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48381", "l": "alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose => a neolactoside IV(3)-alpha-Gal,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421831", "l": "trans-Golgi Network Coat Assembly (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45766", "l": "2 H(+) + L-aspartate + NADH => H2O + L-aspartate 4-semialdehyde + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696958", "l": "USP44 deubiquitinates CDC20 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40628", "l": "H2O + trihexadecanoylglycerol => 2,3-dihexadecanoyl-sn-glycerol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052907", "l": "23S rRNA (adenine(1618)-N(6))-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44495", "l": "3,4-dihydroxy-5-all-trans-decaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209973", "l": "Tyrosine is diiodinated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33734", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> a 1-acyl-sn-glycero-3-phosphocholine + a cardiolipin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38640", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102887", "l": "beta-sesquiphellandrene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13482", "l": "ATP + L-methionine + tRNA(Met) => AMP + diphosphate + L-methionyl-tRNA(Met)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11610", "l": "[(2->8)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA => [(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097573", "l": "glutathione oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66831", "l": "2 ATP + 2 cob(II)alamin + 2 H2O + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)alamin + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54082", "l": "5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine => 5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55073", "l": "2-oxobutanoate + H(+) => CO2 + propanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862184", "l": "USP48 cleaves polyubiquitin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700186", "l": "Autophosphorylation of point mutants of ALK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32772", "l": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate => 2,6-dioxo-6-phenylhexa-3-enoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102791", "l": "sulfuretin synthase activity"}, {"i": "MetaCyc:RXN-8008"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63232", "l": "(2E)-octenoyl-CoA + H(+) + NADH = NAD(+) + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871266", "l": "YAP1 binds TEAD3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63950", "l": "phosphate + sphinga-4E,14Z-dienine => H2O + sphinga-4E,14Z-dienine-1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54455", "l": "a 5,6-dihydrouridine in tRNA + NAD(+) <=> a uridine in tRNA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2509827", "l": "ITPA hydrolyses ITP to IMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8850945", "l": "Casein kinase II phosphorylates PTEN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55118", "l": "(3R)-hydroxy-5-methylhexanoyl-[ACP] + NADP(+) => 5-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19086", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66777", "l": "ATP + H2O + uroporphyrin III(in) => ADP + H(+) + phosphate + uroporphyrin III(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31275", "l": "(S)-3-hydroxy-2-methylpropanoate + NAD(+) = (S)-methylmalonate semialdehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-982765", "l": "Growth hormone forms dimers and oligomers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005142", "l": "interleukin-11 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56847", "l": "nocamycin E + S-adenosyl-L-methionine <=> nocamycin I + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51426", "l": "ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate => a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60197", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(9)-[histone H3] + O2 => CO2 + formaldehyde + L-lysyl(9)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "80.155824608458104", "identifiers": [{"i": "GO:0000977", "l": "RNA polymerase II transcription regulatory region sequence-specific DNA binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099534", "l": "calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13219", "l": "2 H(+) + NADH + succinate => H2O + NAD(+) + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953111", "l": "E2F6 binds TFDP1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66399", "l": "ATP + cholate(in) + glutathione(in) + H2O <=> ADP + cholate(out) + glutathione(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-265456", "l": "NPC1L1 binds ezetimibe (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1470010", "l": "Dimerization of STATs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612671", "l": "ERBB4 gene expression is stimulated by ERBB4s80:ESR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033909", "l": "fucoidanase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247837", "l": "WNT ligands traffic to the Golgi (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8873929", "l": "Casein kinase II phosphorylates STARD10 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31603", "l": "(Z)-3-ureidoacrylate + H2O = (Z)-3-aminoacrylate + carbamate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14831", "l": "acetate + L-cysteine => hydrogen sulfide + O-acetyl-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19750", "l": "[(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->3)-alpha-D-glucosyl](n+1) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2247510", "l": "MARCO:ligand is endocytosed (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.99"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4093332", "l": "p-EPHB phosphorylates SDC2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56676", "l": "dihydroferuloyl-CoA + NADP(+) = (E)-feruloyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27450", "l": "a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O => a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046969", "l": "NAD-dependent histone deacetylase activity (H3-K9 specific)"}, {"i": "REACT:R-HSA-9604829", "l": "SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59211", "l": "ATP + H(+) + octadecanoate <=> diphosphate + octadecanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16266", "l": "O2 + reduced [NADPH--hemoprotein reductase] + trans-5-O-(4-coumaroyl)-D-quinate => 5-O-[(E)-caffeoyl]-D-quinate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11387", "l": "(S)-2-hydroxydecanoate + NAD(+) <=> 2-oxodecanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67143", "l": "L-cysteinyl-[NO transferase protein] + N(omega)-hydroxy-L-arginine + O2 <=> H(+) + H2O + L-citrulline + S-nitroso-L-cysteinyl-[NO transferase protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905030", "l": "voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29346", "l": "L-aspartate(in) + succinate(out) <=> L-aspartate(out) + succinate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2169046", "l": "Degradation of TGF-beta receptor complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58018", "l": "6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59001", "l": "H2O + O2 + propanal => H(+) + H2O2 + propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58154", "l": "2 H(+) + NADH + phosphonoacetate => H2O + NAD(+) + phosphonoacetaldehyde"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005369", "l": "taurine:sodium symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433711", "l": "Cis-homodimerization of nectins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853745", "l": "RET binds GFRA1,GFRA3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948757", "l": "AKT phosphorylates MKRN1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404131", "l": "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41111", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42107", "l": "2-hydroxyethylphosphonate + methylcob(III)alamin + S-adenosyl-L-methionine <=> (S)-2-hydroxypropylphosphonate + 5'-deoxyadenosine + cob(III)alamin + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24793", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate"}, {"i": "EC:4.3.2.10", "l": "\"Imidazole glycerol-phosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38331", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050180", "l": "phloretin hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41832", "l": "(2E)-hexenoyl-[ACP] + H(+) + NADPH = hexanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57413", "l": "AMP + diphosphate + L-tyrosinal + NADP(+) => ATP + H(+) + L-tyrosine + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.58", "l": "\"Lipopolysaccharide glucosyltransferase I\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103011", "l": "mannosylfructose-phosphate synthase activity"}, {"i": "RHEA:26039", "l": "beta-D-fructose 6-phosphate + GDP-alpha-D-mannose = beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + GDP + H(+)"}, {"i": "EC:2.4.1.246", "l": "\"Mannosylfructose-phosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798749", "l": "Exocytosis of specific granule lumen proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23768", "l": "a fatty acyl-CoA + sphing-4-enine = an N-acylsphing-4-enine + CoA + H(+)"}, {"i": "EC:2.3.1.24", "l": "\"Sphingosine N-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29415", "l": "(S)-lactate(in) + H(+)(in) = (S)-lactate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52477", "l": "estrone + UDP-alpha-D-glucuronate => estrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013145", "l": "RAC1 binds effectors at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218847", "l": "PAK2 binds NCK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72672", "l": "The 60S subunit joins the translation initiation complex  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005315", "l": "inorganic phosphate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32150", "l": "H2O + sepiapterin <=> 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48758", "l": "D-erythrulose + H(+) + NADH => erythritol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1483174", "l": "PE is methylated to PC by PEMT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050406", "l": "[acetyl-CoA carboxylase]-phosphatase activity"}, {"i": "RHEA:17125", "l": "H2O + N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine = 2-oxoglutarate + N-(2-aminobutanoyl)glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508451", "l": "PTK2B is phosphorylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6793666", "l": "MDM2 translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49126", "l": "H2O + NADP(+) + protoviolaceinate => H(+) + NADPH + O2 + protodeoxyviolaceinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58195", "l": "dimethylallyl diphosphate + H2O + isopentenyldehydrorhodopin <=> dihydrobisanhydrobacterioruberin + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788628", "l": "p-Y-STATs dissociate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950782", "l": "p-STAT1 binds p-STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166753", "l": "Conversion of C4 into C4a and C4b (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662620", "l": "MT3 binds cadmium (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392263", "l": "AVP(20-28) binds AVPR2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38409", "l": "(9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+) => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58224", "l": "L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265456", "l": "NPC1L1 binds ezetimibe (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40967", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806732", "l": "GNLY binds the bacterial cell surface (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0019181", "l": "halohydrin hydrogen-halide-lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65036", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68849", "l": "Mcm2-7 associates with the Cdt1:CDC6:ORC:origin complex, forming the pre-replicative complex (preRC) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11489", "l": "all-trans-retinol + an acyl-CoA => an all-trans-retinyl ester + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047062", "l": "trans-acenaphthene-1,2-diol dehydrogenase activity"}, {"i": "RHEA:22184", "l": "(+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) = acenaphthene-1,2-dione + 2 H(+) + 2 NADPH"}, {"i": "EC:1.10.1.1", "l": "\"Trans-acenaphthene-1,2-diol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24591", "l": "ATP + D-arabinose <=> ADP + D-arabinose 5-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350477", "l": "RHOGEF2 stimulates nucleotide exchange of RHO1:GDP complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62369", "l": "Fe(2+)(out) + 2 hydrogencarbonate(out) => Fe(2+)(in) + 2 hydrogencarbonate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010945", "l": "CoA pyrophosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482770", "l": "Release of platelet secretory granule components (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418456", "l": "cGMP is degraded by PDEs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47019", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 2 A + 3 H2O <=> [DsrC protein]-dithiol + 2 AH2 + 2 H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443774", "l": "Trans-homodimerization of Neurofascin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32953", "l": "trehalulose => sucrose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42529", "l": "uridine(955/2504/2580) in 23S rRNA => pseudouridine(955/2504/2580) in 23S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507873", "l": "Aquaporins passively transport urea out of cells (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010096", "l": "Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209172", "l": "Phosphorylation of CI by SGG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390886", "l": "HRH4 binds Hist (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47675", "l": "H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-malonyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55422", "l": "CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-[protein] => hexadecanoyl-CoA + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11331", "l": "dimethylallyl diphosphate + isopentenyl diphosphate <=> diphosphate + neryl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41078", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57640", "l": "14 H(+) + holo-[equisetin nonaketide synthase] + 8 malonyl-CoA + 8 NADPH + 2 S-adenosyl-L-methionine = (3-{(1R,2S,6S,8R)-2,8-dimethyl-3-[(E)-prop-1-enyl]-4,5-didehydrodecalin-2-yl}-3-oxopropanoyl)-[equisetin nonaketide synthase] + 8 CO2 + 8 CoA + 6 H2O + 8 NADP(+) + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351876", "l": "Caspase-mediated cleavage of occludin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614185", "l": "Mg2+ binds GRIN1:GRIN2 NMDA receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174224", "l": "Dissociation of Cdc20 from APC/C complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51009", "l": "2 [Fe(III)cytochrome cL] + methanol => 2 [Fe(II)cytochrome cL] + formaldehyde + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43432", "l": "2 [Fe(III)cytochrome c] + butan-1-ol = 2 [Fe(II)cytochrome c] + butanal + 2 H(+)"}, {"i": "EC:1.1.2.9", "l": "\"1-butanol dehydrogenase (cytochrome c)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388503", "l": "Oxytocin receptor bind oxytocin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41597", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H(+) + NADH => (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22370", "l": "D-xylulose 5-phosphate => L-ribulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247847", "l": "WLS is endocytosed to the early endosome (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373732", "l": "Nephrin trans-homophilic interaction (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46701", "l": "(R)-lipoate + GTP + H(+) => (R)-lipoyl-GMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5140741", "l": "WNT5A binds FZD and ROR receptors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618405", "l": "ARL4C mRNA is translated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418091", "l": "F2R binds ARRB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20920", "l": "2,4-dichlorophenol + H(+) + NADPH + O2 = 3,5-dichlorocatechol + H2O + NADP(+)"}, {"i": "EC:1.14.13.20", "l": "\"2,4-dichlorophenol 6-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046559", "l": "alpha-glucuronidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374298", "l": "Opioid receptors bind opioid peptides (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57505", "l": "3-hydroxybutane-1,2,3-tricarboxylate => pyruvate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40709", "l": "1-O-(9Z,12Z,15Z)-octadecatrienylglycerone 3-phosphate + H(+) + hexadecanoate => (9Z,12Z,15Z)-octadecatrien-1-ol + 1-hexadecanoylglycerone 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052868", "l": "protein-lysine lysyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10816", "l": "H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside = L-fucose + methyl beta-D-galactoside"}, {"i": "EC:3.2.1.63", "l": "\"1,2-alpha-L-fucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46083", "l": "(2E)-tetracosenoyl-CoA + H(+) + NADH <=> NAD(+) + tetracosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12389", "l": "formononetin + O2 + reduced [NADPH--hemoprotein reductase] => 2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46527", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25861", "l": "GTP + H2O => 7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22426", "l": "an alkyl thiol + NH4(+) + pyruvate => an S-alkyl-L-cysteine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871227", "l": "RET binds GFRA4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14112", "l": "L-proline + NADP(+) <=> 1-pyrroline-5-carboxylate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3858489", "l": "ppDVL binds DAAM1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29364", "l": "dCMP + H2O => 2'-deoxycytidine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13033", "l": "aldehydo-D-galactose 6-phosphate = keto-D-tagatose 6-phosphate"}, {"i": "EC:5.3.1.26", "l": "\"Galactose-6-phosphate isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202394", "l": "Translocation of CARMA1 to Plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035643", "l": "L-DOPA receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15658", "l": "1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) => 3-methylcatechol + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052717", "l": "tRNA-specific adenosine-34 deaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614461", "l": "Tetramerization of procollagen VI (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63840", "l": "[thioredoxin]-dithiol + tert-butyl hydroperoxide = [thioredoxin]-disulfide + H2O + tert-butanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19280", "l": "ATP + L-pyrrolysine + tRNA(Pyl) <=> AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56411", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z-octadecaenoyl)-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814555", "l": "Integrator complex processes the 3' end of snRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442387", "l": "ZIP8 mediates zinc influx into cells (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34872", "l": "methanol(out) => methanol(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51367", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine <=> CoA + H(+) + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine"}]}
{"type": "biolink:MolecularActivity", "ic": "79.682896251205548", "identifiers": [{"i": "GO:0140457", "l": "protein demethylase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034025", "l": "D-aspartate ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23651", "l": "dTDP-6-deoxy-beta-L-talose + NADP(+) <=> dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51584", "l": "gamma-butyrobetainyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = crotonobetainyl-CoA + reduced [electron-transfer flavoprotein]"}, {"i": "EC:1.3.8.13", "l": "\"Crotonobetainyl-CoA reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47572", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1b (d18:1(4E)) = CMP + ganglioside GT1b (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848250", "l": "ACBD6 binds LCFA-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.4", "l": "\"Nitrite reductase (NAD(P)H)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32226", "l": "(6S)-NADHX + ADP <=> AMP + H(+) + NADH + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38557", "l": "a fatty acid + all-trans-retinol + H(+) => an all-trans-retinyl ester + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-877281", "l": "PIAS1 binds p-STAT1 dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63191", "l": "3,4-dihydroxybenzaldehyde + AH2 + tyramine <=> A + H2O + norbelladine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65130", "l": "1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051082", "l": "unfolded protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021596", "l": "Membrane estrogen receptors bind SRC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373734", "l": "Nephrin interacts with Podocin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17400", "l": "a (3R)-hydroxyacyl-[ACP] + NADP(+) <=> a 3-oxoacyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27819", "l": "L-idonate + NAD(+) => 2-dehydro-L-idonate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54100", "l": "N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.299", "l": "\"Protein N-terminal monomethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176879", "l": "apolipoprotein(a) + LDL => Lp(a) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879910", "l": "JAK2 is phosphorylated, activated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689630", "l": "BAP1 binds BAP1-interacting complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22261", "l": "H2O + triacetate lactone => H(+) + triacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41494", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16428", "l": "formaldehyde + H2O + NAD(+) <=> formate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13378", "l": "alpha-D-glucose 1-phosphate + ATP => ADP + alpha-D-glucose 1,6-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40761", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerone 3-phosphate + hexadecanoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoylglycerone 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26491", "l": "a secondary nitroalkane + H2O + O2 => a ketone + H(+) + H2O2 + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928641", "l": "PAK binds RAC and bPIX (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047462", "l": "phenylalanine racemase (ATP-hydrolyzing) activity"}, {"i": "RHEA:20201", "l": "ATP + H2O + L-phenylalanine = AMP + D-phenylalanine + diphosphate + H(+)"}, {"i": "EC:5.1.1.11", "l": "\"Phenylalanine racemase (ATP-hydrolyzing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18067", "l": "ADP + H(+) + phosphate + phosphonate(in) => ATP + H2O + phosphonate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54678", "l": "(+)-kolavenyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42431", "l": "clavaminate <=> (3R,5R)-clavulanate-9-aldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192061", "l": "CYP46A1 24-hydroxylates CHOL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376122", "l": "DSCAM/DSCAML1 homodimerization (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2167942", "l": "Collagen type XIII ectodomain shedding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-419166", "l": "GEFs activate RhoA,B,C (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20045", "l": "3-oxopropanoate + H2O + NAD(+) = 2 H(+) + malonate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11915", "l": "13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) <=> 15-oxoprostaglandin E2 + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54901", "l": "(2E)-hexadecenoyl-[ACP] + H(+) + NADH => hexadecanoyl-[ACP] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4570528", "l": "SUMOylation of XPC with SUMO1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392749", "l": "Transport of L1 into endosomes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432513", "l": "CLK is phosphorylated by DCO (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30897", "l": "3-aminopropanal + H2O2 + NH4(+) => H2O + O2 + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51291", "l": "(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate <=> (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804402", "l": "TP53 binds POU4F1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042615", "l": "CD154 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53430", "l": "a thymidine in DNA + S-methyl-L-cysteinyl-[protein] => a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665411", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013157", "l": "CDC42 binds effectors at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35403", "l": "(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+) = (3R)-vestitone + H(+) + NADPH"}, {"i": "RHEA:56284", "l": "a (3R,4R)-4,2'-dihydroxyisoflavan + NADP(+) = a (3R)-2'-hydroxyisoflavanone + H(+) + NADPH"}, {"i": "EC:1.1.1.348", "l": "\"(3R)-2'-hydroxyisoflavanone reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168376", "l": "STIM1 oligomerizes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16771", "l": "(2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+) => (2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31038", "l": "arabidiol <=> (S)-2,3-epoxysqualene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33777", "l": "1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+) => a 1,2-diacyl-sn-glycerol + CDP-N,N-dimethylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19268", "l": "carnitine + NAD(+) <=> 3-dehydrocarnitine + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050229", "l": "pterocarpin synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2203516", "l": "Alpha-1-Microglobulin is cleaved (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005127", "l": "ciliary neurotrophic factor receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139941", "l": "Binding of IP3 to IP3 receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52549", "l": "L-threonate + NAD(+) => 2-dehydro-L-erythronate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30275", "l": "AH2 + H2O2 = A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047992", "l": "hydroxylysine kinase activity"}, {"i": "KEGG.REACTION:R03378"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26100", "l": "(4R)-limonene + H(+) + NADPH + O2 <=> H2O + limonene 1,2-epoxide + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61314", "l": "germacra-1(10),4,11(13)-trien-12-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-ol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111915", "l": "CAMK4 autophosphorylates (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419645", "l": "Dimerization of LIMK1 by Hsp90 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27697", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate <=> (S)-3-methyl-2-oxopentanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31106", "l": "7,8-dihydrofolate + NADP(+) <=> folate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11168", "l": "3-hydroxy-6-carboxyhexanoyl-CoA + NAD(+) = 3-oxo-6-carboxyhexanoyl-CoA + H(+) + NADH"}, {"i": "EC:1.1.1.259", "l": "\"3-hydroxypimeloyl-CoA dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668831", "l": "CST complex formation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10870", "l": "a triacyl-sn-glycerol + CoA => a 1,2-diacyl-sn-glycerol + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "62.02868707118116", "identifiers": [{"i": "GO:0016791", "l": "phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008815", "l": "citrate (pro-3S)-lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193684", "l": "p62 recruits an atypical PKC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29075", "l": "formate(out) + 2 H(+)(in) + ubiquinone-8 = CO2(out) + H(+)(out) + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62793", "l": "3 H(+) + NADPH + O2 + 2 rubrofusarin B => 2 H2O + NADP(+) + nigerone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55218", "l": "diphosphate + rhizathalene A => (2E,6E,10E)-geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41016", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol => 1-O-hexadecyl-2-acetyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10981", "l": "L-serine => D-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2012086", "l": "Constitutive dimerization of FGFR4 Y367C mutant (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606839", "l": "Steryl sulfatase hydrolyses sulfate from steroid sulfates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42461", "l": "dibenzofuran + H(+) + NADH + O2 => biphenyl-2,2',3-triol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35207", "l": "H2O + IDP = H(+) + IMP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10038", "l": "H2O2 + vanillin => 4-hydroxy-3-methoxy-benzenemethanol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0000829", "l": "inositol heptakisphosphate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790987", "l": "NAT10 acetylates cytidine-1337 and cytidine-1842 of 18S rRNA yielding 4-acetylcytidine-1377 and 4-acetylcytidine-1842 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193981", "l": "CYP21A2 oxidises 17HPROG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46443", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + AH2 + O2 <=> A + a (8E,10E,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22099", "l": "phosphate + RNA(n+1) <=> a ribonucleoside 5'-diphosphate + RNA(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49740", "l": "2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate = CO2 + deoxyviolacein + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24274", "l": "H2O + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+) => H(+) + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163418", "l": "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64903", "l": "H2O + UTP <=> H(+) + phosphate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31440", "l": "(2E,6E)-farnesyl diphosphate => alpha-longipinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984021", "l": "STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41205", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14530", "l": "ADP + D-ribose 5-phosphate + H(+) => ADP-D-ribose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24630", "l": "5 H(+) + 3 NADH + nitrite => 2 H2O + 3 NAD(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32547", "l": "(2E)-geranyl diphosphate = (1R,5R)-sabinene + diphosphate"}, {"i": "EC:4.2.3.110", "l": "\"(+)-sabinene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63799", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + H2O <=> C-terminal L-alpha-aminoacyl-[tubulin] + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15447", "l": "CO2 + 2 NH4(+) + pyruvate => H(+) + H2O + O-carbamoyl-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549533", "l": "Expression of PERIOD-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38632", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2426566", "l": "Interaction of DAP12 and CLM7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201634", "l": "Caspase-mediated cleavage of FADK 1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416530", "l": "FFAR1:FFAR1 ligands activates Gq (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44295", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CDP-ethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395517", "l": "NADPH transfers electrons to FDXR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371567", "l": "DBC1 is phosphorylated by ATM/ART (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13941", "l": "ATP + D-glyceraldehyde = ADP + D-glyceraldehyde 3-phosphate + H(+)"}, {"i": "EC:2.7.1.28", "l": "\"Triokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16620", "l": "beta-D-glucosyl-(1->3)-D-glucose + phosphate <=> alpha-D-glucose 1-phosphate + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14415", "l": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) => biphenyl-2,3-diol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38105", "l": "2-dehydro-3-deoxy-L-galactonate + H2O => L-galactonate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904599", "l": "advanced glycation end-product binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38109", "l": "L-glyceraldehyde + pyruvate => 2-dehydro-3-deoxy-L-galactonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807106", "l": "PTEN undergoes monoubiquitination (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848758", "l": "PTK6 phosphorylates AKT1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10222", "l": "AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr) => ATP + L-tyrosine + tRNA(Tyr)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19711", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66893", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862084", "l": "PILRA,PILRB bind CD99 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451347", "l": "Activation of JNK by DSCAM (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23734", "l": "ADP + CO2 + isopentenyl diphosphate + phosphate => (R)-5-diphosphomevalonate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46440", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + AH2 + O2 = A + a (8E,10E,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O"}, {"i": "EC:1.14.19.14", "l": "\"Linoleoyl-lipid Delta(9) conjugase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605797", "l": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014293", "l": "RAC2 GDIs block activation of RAC2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028817", "l": "CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948136", "l": "ULK1 Translocates to the mitochondria (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052613", "l": "canthaxanthin 3-hydroxylase activity"}, {"i": "MetaCyc:RXN-8186"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25723", "l": "L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46130", "l": "4beta-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046180", "l": "KSPG is secreted from the cell (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977629", "l": "Displacement of C2a/Bb by CR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24687", "l": "H2O + N-formylmethanofuran => formate + methanofuran"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10694", "l": "H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone => 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43706", "l": "diphosphate + tetradecanoyl-AMP => ATP + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63231", "l": "ATP + spectinomycin <=> 9-O-adenylylspectinomycin + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30982", "l": "A + all-trans-lycopene <=> AH2 + all-trans-3,4-didehydrolycopene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27691", "l": "ATP + dGDP => ADP + dGTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5615556", "l": "Defective POMT2 does not transfer Man from Dol-P-Man to DAG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27888", "l": "3'-AMP + H(+) => 2',3'-cyclic AMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390425", "l": "FAR1 reduces PalmCoA to HXOL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390673", "l": "CHRM2,4 bind acetylcholine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49393", "l": "20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,23,24-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54863", "l": "(2E)-geranial + H(+) + NADPH + O2 <=> (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9690461", "l": "FKBP1A binds tacrolimus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64751", "l": "H2O + S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine <=> 2-methyl-3-sulfanylbutan-1-ol + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0005313", "l": "L-glutamate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34888", "l": "selenate(in) => selenate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28938", "l": "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate <=> oxaloacetate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168897", "l": "LRP1 (CD91) binds Hemopexin:heme (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47624", "l": "cis-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O"}, {"i": "EC:4.2.1.171", "l": "\"Cis-l-3-hydroxyproline dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656209", "l": "Dissociation of RAS:RAF1 mutant complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42285", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696146", "l": "AOC2 deaminates TYR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12695", "l": "3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate + H(+) => 3,4-dihydroxypyridine + O-acetyl-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48772", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a = 3-deacetyl-3-vinylbacteriochlorophyllide a + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34619", "l": "1-deoxypentalenate + 2-oxoglutarate + O2 = 1-deoxy-11beta-hydroxypentalenate + CO2 + succinate"}, {"i": "EC:1.14.11.35", "l": "\"1-deoxypentalenic acid 11-beta-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2002460", "l": "P4HB binds Collagen chains (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103046", "l": "alanylglutamate dipeptidase activity"}, {"i": "MetaCyc:RXN0-6981"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.51"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050015", "l": "kievitone hydratase activity"}, {"i": "RHEA:23604", "l": "kievitone hydrate = H2O + kievitone"}, {"i": "EC:4.2.1.95", "l": "\"Kievitone hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24576", "l": "diphosphate + H2O = H(+) + 2 phosphate"}, {"i": "EC:3.6.1.1", "l": "\"Inorganic diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696275", "l": "RND2 binds GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197645", "l": "SCARF1 (SREC-I) binds ligands (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29915", "l": "L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose = alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31214", "l": "ATP + H2O + L-selenomethionine <=> diphosphate + L-adenosylselenomethionine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41908", "l": "(3R)-hydroxyhexadecanoyl-[ACP] = (2E)-hexadecenoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32222", "l": "all-trans-lycopene <=> gamma-carotene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19423", "l": "(R)-1,2-epoxypropane + coenzyme M => (R)-2-hydroxypropyl-coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17642", "l": "H(+) + L-arginine => agmatine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665998", "l": "MKL1 binds SRF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58997", "l": "H2O + indole-3-carbaldehyde + O2 => H(+) + H2O2 + indole-3-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2272668", "l": "Interaction of DAP12 and KIR2DS5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45344", "l": "globoside NOR1 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = globoside NORint (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17216", "l": "UDP-N-acetyl-alpha-D-glucosamine <=> UDP-N-acetyl-alpha-D-mannosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605797", "l": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66146", "l": "CoA + H(+) + melatonin => 5-methoxytryptamine + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56783", "l": "(+)-piperitol + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-sesamin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49487", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(in) + ATP + H2O <=> 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60393", "l": "Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O => Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008928", "l": "IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664976", "l": "Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34017", "l": "ergosterol + 2 H2O + NADP(+) => ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445448", "l": "HHIP binds Hedgehog (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41019", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol = 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43494", "l": "chlorophyll b + H(+) + NADPH => 7(1)-hydroxychlorophyll a + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63684", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + ATP = (4R,5S)-dethiobiotin + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44963", "l": "(2E)-decenoyl-CoA + H(+) + NADPH <=> decanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0047635", "l": "alanine-oxo-acid transaminase activity"}, {"i": "MetaCyc:ALANINE--OXO-ACID-AMINOTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388468", "l": "AVP(20-28) binds AVPR1A,B (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35589", "l": "phosphate + riboflavin => FMN + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869568", "l": "NPM1 binds TFAP2A homodimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042561", "l": "alpha-amyrin synthase activity"}, {"i": "MetaCyc:RXN-8434"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799761", "l": "TP53 binds PPP1R13L (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28956", "l": "D-glucuronate(in) + H(+)(in) => D-glucuronate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390930", "l": "5-HT2 receptor can bind serotonin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64877", "l": "H2O + UDP => H(+) + phosphate + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41995", "l": "17beta-hydroxy-5alpha-androstan-3-one + NAD(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032542", "l": "sulfiredoxin activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102765", "l": "UDP-D-apiose synthase activity"}, {"i": "MetaCyc:RXN-7770"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22850", "l": "3-oxooctanedioyl-CoA + H(+) + NADH => (3S)-hydroxyoctanedioyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36221", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31871", "l": "(S)-2,3-epoxysqualene = alpha-seco-amyrin"}, {"i": "EC:5.4.99.52", "l": "\"Alpha-seco-amyrin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57928", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate"}, {"i": "EC:6.3.5.13", "l": "\"Lipid II isoglutaminyl synthase (glutamine-hydrolyzing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5684096", "l": "CDK2 phosphorylates RBBP8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13615", "l": "beta-D-fructose 1,6-bisphosphate + H(+) + phosphate => beta-D-fructose 6-phosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15286", "l": "AMP + dimethylallyl diphosphate => diphosphate + N(6)-(dimethylallyl)adenosine 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55592", "l": "2 (3R)-hydroxydecanoyl-[ACP] + H2O = (3R)-3-[(3R)-3-hydroxydecanoyloxy]decanoate + H(+) + 2 holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39207", "l": "3-oxohexacosanoyl-CoA + H(+) + NADPH = (3R)-hydroxyhexacosanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112434", "l": "Formation of DSIF complex  (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11274", "l": "a 2-oxocarboxylate + a quinol => a (2R)-2-hydroxycarboxylate + a quinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25145", "l": "3-hydroxyanthranilate + H(+) + L-alanine => 3-hydroxy-L-kynurenine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29240", "l": "H(+)(in) + uracil(in) => H(+)(out) + uracil(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036393", "l": "thiocyanate peroxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11481", "l": "3-hydroxybenzoate + H(+) + NADPH + O2 => 3,4-dihydroxybenzoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54960", "l": "ATP + CoA + dinor-OPDA = AMP + dinor-OPDA-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55602", "l": "a mannosylinositol-1-phosphoceramide + GDP + H(+) => an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61813", "l": "3beta-hydroxyandrost-5-en-17-one + UDP-alpha-D-glucose => dehydroepiandrosterone 3-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664850", "l": "ATM binds PEX5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48888", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "74.836269892493803", "identifiers": [{"i": "GO:0046872", "l": "metal ion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43761", "l": "acetyl-CoA + N-terminal L-seryl-[ribosomal protein bL12] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[ribosomal protein bL12]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37964", "l": "galactitol + NAD(+) => D-galactose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39804", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+) => (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12373", "l": "2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O => 4-oxohex-2-enedioate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14727", "l": "2 adenosylcob(III)inamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate => 2 ATP + 2 cob(II)inamide + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209061", "l": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0008417", "l": "fucosyltransferase activity"}, {"i": "REACT:R-HSA-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429415", "l": "SYK binds to integrin alphaIIb beta3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9010681", "l": "PKC phosphorylates ROBO3.1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022873", "l": "protein-N(PI)-phosphohistidine-maltose phosphotransferase system transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654514", "l": "KAL1 binds FGFR1c (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49851", "l": "(-)-dehydrodiconiferyl acid ketone + a quinone + H2O <=> (-)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54031", "l": "a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610741", "l": "PKA phosphorylates GLI1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50463", "l": "a medium chain fatty acid + ATP + holo-[ACP] <=> a medium-chain fatty acyl-[ACP] + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60111", "l": "(R)-3-(4-hydroxyphenyl)lactoyl-CoA <=> (E)-4-coumaroyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53735", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminosalicylate <=> 2-hydroxy-7,8-dihydropteroate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41935", "l": "H2O + hexadecanoyl-[ACP] <=> H(+) + hexadecanoate + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58433", "l": "(E)-4-oxonon-2-en-1-ol + NADP(+) => (E)-4-oxonon-2-enal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0030557", "l": "tRNA modification guide activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23571", "l": "(2E)-decenoyl-[ACP] <=> (3Z)-decenoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551648", "l": "SUMOylation of TDG with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982810", "l": "JAK2 phosphorylation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18752", "l": "[protein]-dithiol + NAD(+) <=> [protein]-disulfide + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017954", "l": "MECP2:SIN3A complex binds OPRM1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37254", "l": "cysteamine S-phosphate + H2O <=> cysteamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21310", "l": "cycloartenol => (S)-2,3-epoxysqualene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167121", "l": "Addition of the third nucleotide on the nascent HIV-1 transcript (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45283", "l": "12-(phosphooxy)octadecanoate + H2O <=> 12-hydroxyoctadecanoate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16534", "l": "L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57587", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 2-hydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57191", "l": "H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] <=> glycolate + H(+) + L-arginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49468", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-6-sulfoquinovose = a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046572", "l": "versicolorin B synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204850", "l": "Interaction of Tie2 and Dok-2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247840", "l": "WLS binds WNT ligands in the Golgi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57815", "l": "1-chloro-2-nitrobenzene + NADH + O2 <=> 3-chlorocatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050530", "l": "glucosylglycerol 3-phosphatase activity"}, {"i": "RHEA:22652", "l": "2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + H2O = 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate"}, {"i": "EC:3.1.3.69", "l": "\"Glucosylglycerol 3-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210439", "l": "glutamate uptake by astrocytes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48359", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39186", "l": "3-oxodocosanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxydocosanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30913", "l": "a carboxylate + sphing-4-enine-phosphocholine => a sphingomyelin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225957", "l": "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63063", "l": "5-methylorsellinate + ATP + H(+) + NADPH <=> 2,4-dihydroxy 5,6-dimethylbenzaldehyde + AMP + diphosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12059", "l": "D-erythrose 4-phosphate + H2O + NAD(+) <=> 4-phospho-D-erythronate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003962", "l": "cystathionine gamma-synthase activity"}, {"i": "RHEA:20397", "l": "L-cysteine + O-succinyl-L-homoserine = H(+) + L,L-cystathionine + succinate"}, {"i": "EC:2.5.1.48", "l": "\"Cystathionine gamma-synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43018", "l": "2-aminoprop-2-enoate + an alkyl thiol => an S-alkyl-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950518", "l": "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1470009", "l": "Phosphorylation of STATs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19351", "l": "(R)-3,3-dimethylmalate + 2 H(+) + NADH => (R)-4-dehydropantoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31149", "l": "3,4-dihydroxymandelaldehyde + H(+) + NADH => 3,4-dihydroxyphenylethyleneglycol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000263", "l": "TCII:Cbl is degraded to release Cbl (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43205", "l": "cytidine(1409) in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(1409) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018746", "l": "RHOQ binds effectors at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.26"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32524", "l": "nigerose + phosphate => beta-D-glucose 1-phosphate + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668831", "l": "CST complex formation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38453", "l": "NADPH + (n+1) sulfur => hydrogen sulfide + NADP(+) + n sulfur"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867613", "l": "PICALM binds R-SNAREs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18618", "l": "ATP + oxaloacetate => ADP + CO2 + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375151", "l": "Interaction of NCAM1 with collagens (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47242", "l": "(2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18284", "l": "NAD(+) + succinate <=> fumarate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16803", "l": "adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein] => 3'-phosphoadenylyl sulfate + L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:1901702", "l": "salt transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617866", "l": "HOXC4 gene is transcribed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62665", "l": "(2'R)-atrovenetin + S-adenosyl-L-methionine => deoxyherqueinone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26456", "l": "acryloyl-CoA + H(+) + NADPH => NADP(+) + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52912", "l": "3-dimethylallyl-4-hydroxymandelate + O2 = 3-dimethylallyl-4-hydroxybenzoate + CO2 + H2O"}, {"i": "EC:1.13.12.23", "l": "\"4-hydroxy-3-prenylbenzoate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.15.1", "l": "\"Venom exonuclease\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042806", "l": "fucose binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64673", "l": "2-(methylsulfanyl)acetyl-CoA + butan-1-ol => butyl 2-(methylsulfanyl)acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32663", "l": "5-guanidino-2-oxopentanoate + S-adenosyl-L-methionine = 5-guanidino-3-methyl-2-oxopentanoate + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.243", "l": "\"2-ketoarginine methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008271", "l": "CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877922", "l": "BGLAP gene expression is stimulated by RUNX2, WWTR1 and RB1 and inhibited by AR, YAP1 and ZNF521 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32818", "l": "Hg(2+)(in) <=> Hg(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080076", "l": "caffeoyl CoA:S-adenosyl-L-methionine O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21910", "l": "H(+) + NADPH + naphthalene-1,3,6,8-tetrol => NADP(+) + scytalone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37680", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19218", "l": "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane => 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38499", "l": "a triacyl-sn-glycerol + H2O = a 2,3-diacyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25691", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) => CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60435", "l": "A + cannabigerolate <=> AH2 + cannabichromenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64842", "l": "CoA + phenethyl benzoate => 2-phenylethanol + benzoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12007", "l": "indoxyl + UDP-alpha-D-glucose <=> H(+) + indican + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23325", "l": "2'-phospho-[ligated tRNA] + NAD(+) => ADP-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23202", "l": "formaldehyde + H2O2 + L-lysine => H2O + N(6)-methyl-L-lysine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109813", "l": "GRB2-1 binds SOS1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005309", "l": "creatine:sodium symporter activity"}, {"i": "REACT:R-HSA-200396", "l": "Creatine transport across the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786650", "l": "DDHD1,2 hydrolyse PA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10746", "l": "3,4-dihydroxybenzoate + CO2 + NADH => (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36839", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50432", "l": "AH2 + prostaglandin G1 = A + H2O + prostaglandin H1"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106351", "l": "aspartate dehydrogenase NAD activity"}, {"i": "RHEA:11788", "l": "H2O + L-aspartate + NAD(+) = H(+) + NADH + NH4(+) + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008725", "l": "DNA-3-methyladenine glycosylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58809", "l": "2',3'-cGAMP + 2 H2O => AMP + GMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28890", "l": "H(+)(in) + L-serine(in) <=> H(+)(out) + L-serine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693598", "l": "ATM phosphorylates NBN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29455", "l": "D-serine(in) = D-serine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189488", "l": "UROS transforms HMB to URO3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18287", "l": "a carboxylate + D-aspartate => an N-acyl-D-aspartate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65216", "l": "3-oxododecanoyl-CoA + H2O = 3-oxododecanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12684", "l": "creatinine + H(+) + H2O <=> N-methylhydantoin + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21228", "l": "alpha-maltose = beta-maltose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45031", "l": "(2S)-methylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> 2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40034", "l": "ent-copalyl diphosphate + H2O <=> diphosphate + ent-manool"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0004180", "l": "carboxypeptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46234", "l": "(9Z,12Z,15Z)-hexadecatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (9Z,12Z)-hexadecadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57776", "l": "2-chloro-6-nitrotoluene + NADH + O2 = 4-chloro-3-methylcatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35511", "l": "glycyrrhetaldehyde + O2 + reduced [NADPH--hemoprotein reductase] = glycyrrhetinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2534365", "l": "Slo3 Potassium Transport (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13197", "l": "H(+) + sulfite + UDP-alpha-D-glucose = H2O + UDP-alpha-D-6-sulfoquinovose"}, {"i": "EC:3.13.1.1", "l": "\"UDP-sulfoquinovose synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30085", "l": "4 Cu(2+) + 2 H2O => 4 Cu(+) + 4 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41347", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> (5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45092", "l": "H2O + N-octanoylsphing-4-enine = octanoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34245", "l": "diphosphate + Mo-molybdopterin guanine dinucleotide => GTP + H(+) + Mo-molybdopterin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34303", "l": "L-lysine = L-pipecolate + NH4(+)"}, {"i": "EC:4.3.1.28", "l": "\"L-lysine cyclodeaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013435", "l": "RHOD auto-activates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42082", "l": "all-trans-retinoate + 2 H(+) + NADH => all-trans-retinal + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29286", "l": "L-alanine(in) + Na(+)(in) <=> L-alanine(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8858252", "l": "HDLBP binds HDL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004360", "l": "glutamine-fructose-6-phosphate transaminase (isomerizing) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66754", "l": "(2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(out) + ADP + H(+) + phosphate => (2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40821", "l": "(9Z)-octadecenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29930", "l": "(R)-pantothenate(in) + Na(+)(in) <=> (R)-pantothenate(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12158", "l": "2-glutathionyl-2-methylbut-3-enoate + 3 H(+) + 2 NADH => 2-glutathionyl-2-methylbut-3-en-1-ol + H2O + 2 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39734", "l": "3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20006", "l": "an alpha-D-glucuronoside + H2O => an alcohol + D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15304", "l": "D-apiitol + NAD(+) <=> aldehydo-D-apiose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30841", "l": "UDP-N-acetyl-beta-L-fucosamine => UDP-2-acetamido-2,6-dideoxy-beta-L-talose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.113", "l": "\"Deoxyguanosine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696131", "l": "AOC1 deaminates Hist (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014449", "l": "RHOG binds effectors at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15126", "l": "acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n) => CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17641", "l": "H(+) + L-arginine = agmatine + CO2"}, {"i": "EC:4.1.1.19", "l": "\"Arginine decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53023", "l": "a plastoquinone + an L-alpha-amino acid + H2O <=> a 2-oxocarboxylate + a plastoquinol + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102333", "l": "stearoyl-[acp] elongase/decarboxylase activity"}, {"i": "MetaCyc:RXN-13261"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45582", "l": "D-galactaro-1,4-lactone => D-galactaro-1,5-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41379", "l": "1-O-decyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-decyl-sn-glycero-3-phosphocholine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797974", "l": "LRRTMs bind NRXNs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13048", "l": "ent-kaur-16-ene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-kaur-16-en-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.28", "l": "\"2-phospho-L-lactate transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604368", "l": "Autocatalytic activation of bound proMMP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40110", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA <=> 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9670114", "l": "Histone H3.3 deposition at telomere (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42703", "l": "6-carboxyhexanoyl-[ACP] methyl ester + H2O <=> 6-carboxyhexanoyl-[ACP] + H(+) + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57090", "l": "3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+) => an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247843", "l": "secretion of WNT ligands (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-481009", "l": "Exocytosis of platelet dense granule content (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805059", "l": "CK2:FACT phosphorylates TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050072", "l": "m7G(5')pppN diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61911", "l": "2 ATP + benzoate + L-phenylalanine + N-benzoyl-L-phenylalaninol <=> 2 AMP + asperphenamate + 2 diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46505", "l": "dodecanoyl-AMP + holo-[ACP] => AMP + dodecanoyl-[ACP] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53257", "l": "5alpha-cholest-7-en-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha,8alpha-epoxy-5alpha-cholestan-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20114", "l": "beta-D-glucose 1-phosphate => beta-D-glucose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19472", "l": "NADH + 2 nitric oxide + 2 O2 <=> H(+) + NAD(+) + 2 nitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28824", "l": "H(+)(in) + L-galactonate(in) => H(+)(out) + L-galactonate(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047903", "l": "fructose 5-dehydrogenase (NADP+) activity"}, {"i": "MetaCyc:FRUCTOSE-5-DEHYDROGENASE-NADP+-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004924", "l": "oncostatin-M receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448948", "l": "Phosphorylation of E proteins by p38 MAPK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873927", "l": "Release of STAT1 dimer from active receptor unit (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76031", "l": "2 H2O2 => O2 + 2 H2O (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10394", "l": "(E)-cinnamaldehyde + H(+) + NADPH => (E)-cinnamyl alcohol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033292", "l": "NTRK2 and CDK5 promote activation of RAC1 by TIAM1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031881", "l": "type 4 somatostatin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3341294", "l": "Superoxide reduces cytochrome c (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53410", "l": "(4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11435", "l": "S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside <=> 7-O-methylvitexin 2''-O-beta-L-rhamnoside + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45314", "l": "H(+) + NADPH + prostaglandin H2 => NADP(+) + prostaglandin F2alpha"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27664", "l": "2-oxoglutarate + H2O2 => (S)-2-hydroxyglutarate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977301", "l": "Histidine is decarboxylated to histamine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31454", "l": "2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> a cardiolipin + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60015", "l": "a tRNA with a 3' CC end + ATP <=> a tRNA with a 3' CCA end + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45612", "l": "H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168635", "l": "PRKCB (PKC-beta) phosphorylates CARMA1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9005340", "l": "Expression of SOCS3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854466", "l": "VLDLR binds RELN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57842", "l": "1D-myo-inositol 1-phosphate + phosphate => 1D-myo-inositol 1,3-bisphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68914", "l": "DNA polymerase alpha:primase binds at the origin (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022856", "l": "protein-N(PI)-phosphohistidine-sorbitol phosphotransferase system transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190829", "l": "Lysosomal degradation of gap junction plaques (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19343", "l": "H2O + octan-1-ol + 2 oxidized [rubredoxin] => 2 H(+) + O2 + octane + 2 reduced [rubredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33647", "l": "(9Z)-hexadecenoate + ATP + CoA = (9Z)-hexadecenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3132759", "l": "TCN1 binds Cbl (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64169", "l": "2-ethyl-L-serine => (2S)-2-aminobutanoate + formaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192051", "l": "CYP7A1 7-hydroxylates CHOL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857686", "l": "FITM1, FITM2 bind TAGs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17082", "l": "S-adenosyl-L-methionine + trans-isoeugenol => H(+) + S-adenosyl-L-homocysteine + trans-isomethyleugenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36661", "l": "novobiocin + phosphate => carbamoyl phosphate + descarbamoylnovobiocin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16646", "l": "H2O + hexadecanoyl-CoA => CoA + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130194", "l": "ABL phosphorylates WAVEs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043873", "l": "pyruvate-flavodoxin oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029468", "l": "Conversion of PA into DAG by PAP-1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-167408", "l": "The high affinity receptor complex binds to G-protein (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102654", "l": "1-18:1-2-16:0-phosphatidylglycerol trans-3 desaturase activity"}, {"i": "RHEA:46764", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.19.43", "l": "\"Palmitoyl-[glycerolipid] 3-(E)-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64461", "l": "acetyl phosphate + L-lysyl-[protein] => H(+) + N(6)-acetyl-L-lysyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264622", "l": "Cho is acetylated to AcCho by CHAT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700154", "l": "Active ALK binds SHC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031803", "l": "type 6 metabotropic glutamate receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49605", "l": "2-glutathionyl-2-methylbut-3-en-1-ol + NAD(+) => 2-glutathionyl-2-methylbut-3-enal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112514", "l": "JAK activation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41247", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 9R-hydroperoxy(5Z,7E,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0101016", "l": "FMN-binding domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16984", "l": "3-oxoadipate + NAD(+) <=> H(+) + maleylacetate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10291", "l": "H2O + L-rhamnono-1,4-lactone <=> H(+) + L-rhamnonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43734", "l": "1,3-diacyl-sn-glycerol + a fatty acid + H(+) => a triacyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990601", "l": "5' overhang single-stranded DNA endodeoxyribonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035950", "l": "Defective B4GALT1 does not transfer Gal to a branch of keratan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983150", "l": "Proteasomal cleavage of substrate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114354", "l": "SMAC binds XIAP:Caspase-7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77609", "l": "Binding of APOBEC-1 to form editosome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48814", "l": "(5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72663", "l": "De novo formation of eIF2:GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-354073", "l": "Autophosphorylation of PTK2 at Y397 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48299", "l": "H2O + prostaglandin E2 1-glyceryl ester <=> glycerol + H(+) + prostaglandin E2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676595", "l": "TRAFs bind RANK:RANKL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57526", "l": "a 5'-phospho-guanosine-ribonucleotide-tRNA(His) + diphosphate + H(+) => a 5'-triphospho-guanosine-ribonucleotide-tRNA(His) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42961", "l": "H(+) + NAD(+) + 2 reduced [nitric oxide reductase rubredoxin domain] => NADH + 2 oxidized [nitric oxide reductase rubredoxin domain]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-451418", "l": "Pellino ubiquitinates IRAK1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42383", "l": "2 A + all-trans-4,4'-diapolycopene-4,4'-dial + 2 H2O <=> 2 AH2 + all-trans-4,4'-diapolycopene-4,4'-dioate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0017024", "l": "myosin I binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23775", "l": "(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) <=> 2,3-dihydroxy-p-cumate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42268", "l": "2-methylpropanoyl-CoA + H(+) + malonyl-[ACP] = 4-methyl-3-oxopentanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33896", "l": "NAD(+) + trans,octa-cis-decaprenylphospho-beta-D-arabinofuranose => H(+) + NADH + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046962", "l": "sodium-transporting ATPase activity, rotational mechanism"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-997237", "l": "SH2B proteins bind JAK2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873850", "l": "STARD5 binds DCA, LCA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59180", "l": "5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O = 2 AMP + H(+)"}, {"i": "EC:3.1.4.60", "l": "\"PApA phosphodiesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48176", "l": "decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43279", "l": "ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GalNAc-GD1a + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11664", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + CMP-N-acetyl-beta-neuraminate = 1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+)"}, {"i": "EC:2.4.99.5", "l": "\"Galactosyldiacylglycerol alpha-2,3-sialyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30894", "l": "O-acetyl-L-serine + thiosulfate <=> acetate + H(+) + S-sulfo-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51096", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798749", "l": "Exocytosis of specific granule lumen proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53158", "l": "H(+) + H2O + N-(5,6-epoxy-8Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004837", "l": "tyrosine decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247960", "l": "Activation of p38 MAPK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19880", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14684", "l": "2 2-aminophenol + A + O2 <=> 2-aminophenoxazin-3-one + AH2 + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018532", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55090", "l": "(24Z)-ethylidenelanosterol + H(+) + S-adenosyl-L-homocysteine => 24-methylene-24-dihydrolanosterol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55258", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63888", "l": "hexadecanoyl-CoA + sphinga-4E,14Z-dienine = CoA + H(+) + N-hexadecanoyl-sphinga-4E,14Z-dienine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008160", "l": "protein tyrosine phosphatase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798743", "l": "Exocytosis of secretory granule membrane proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64439", "l": "glycylglycyl-L-isoleucine(out) + H(+)(out) <=> glycylglycyl-L-isoleucine(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809521", "l": "BPIF binds bacteria (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391372", "l": "GNRHR binds GNRH1,2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57591", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-2-hydroxynaringenin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851298", "l": "GPR143 binds L-Dopa (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928597", "l": "EPH:EFN dimers tetramerise (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21962", "l": "2-C-methyl-D-erythritol 2,4-cyclic diphosphate + [protein]-dithiol => (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + [protein]-disulfide + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47654", "l": "phosphate + ribitol => D-ribitol 1-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42727", "l": "guanosine(2922) in 27S pre-rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(2922) in 27S pre-rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71303", "l": "RPE dimers isomerise RU5P to XY5P (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41764", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD3 (d18:1(4E)) = CMP + ganglioside GT3 (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-870538", "l": "TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38576", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60271", "l": "N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51000", "l": "[fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine = [fructose-bisphosphate aldolase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.259", "l": "\"[Fructose-bisphosphate aldolase]-lysine N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-179421", "l": "Degradation of multiubiquitinated Nek2A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.13"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036478", "l": "L-dopa decarboxylase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44098", "l": "CoA + decanyl hexadecanoate => decan-1-ol + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40916", "l": "1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25719", "l": "H(+) + N,N-dihydroxy-L-trihomomethionine = (E)-6-(methylsulfanyl)hexanal oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.41", "l": "\"Riboflavin reductase (NAD(P)H)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56405", "l": "[(3R)-hydroxybutanoate](n) + H2O => (3R)-hydroxybutanoate pentamer + [(3R)-hydroxybutanoate](n-5) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4655374", "l": "SUMOylation of DNMT3B with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693593", "l": "D-loop extension by DNA polymerases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57949", "l": "2-hydroxytoluene + H(+) + NADH + O2 => 3-methylcatechol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63997", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29633", "l": "alpha-D-glucose + alpha-maltotriose => alpha-maltotetraose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3149539", "l": "MTR transfers CH3 group from MTHF to cob(I)alamin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332390", "l": "Translocation and activation of PKC alpha in response to WNT signaling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16169", "l": "ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate"}, {"i": "EC:6.3.1.2", "l": "\"Glutamine synthetase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102378", "l": "steviolmonoside glucosyltransferase activity"}, {"i": "MetaCyc:RXN-13512"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.18", "l": "\"Aspergillopepsin I\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1250280", "l": "ROS oxidize thioredoxin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32006", "l": "(+)-copalyl diphosphate <=> diphosphate + isopimara-8(14),15-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430135", "l": "p-SLP-76 binds ADAP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13588", "l": "ATP + butanoate <=> ADP + butanoyl phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043759", "l": "methylbutanoate-CoA ligase activity"}, {"i": "RHEA:46180", "l": "2-methylbutanoate + ATP + CoA = 2-methylbutanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632668", "l": "SMO translocates to the cilium (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29794", "l": "ATP + glutathione(out) + H2O <=> ADP + glutathione(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404134", "l": "RBP4:atROL binds TTR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035197", "l": "siRNA binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003911", "l": "DNA ligase (NAD+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186786", "l": "Autophosphorylation of PDGF beta receptors (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018825", "l": "RHOT2 GEFs activate RHOT2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50101", "l": "dodecanoyl-CoA + taurine => CoA + H(+) + N-dodecanoyl-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22941", "l": "ATP + L-arginine => ADP + H(+) + N(omega)-phospho-L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814088", "l": "SYS1 binds AcM-ARFRP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669024", "l": "CD70 binds CD27 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.105", "l": "\"All-trans-retinol dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22720", "l": "ATP + L-histidyl-[protein] = ADP + H(+) + N(pros)-phospho-L-histidyl-[protein]"}, {"i": "EC:2.7.13.1", "l": "\"Protein-histidine pros-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35826", "l": "5,6,7,8-tetrahydromethanopterin + NAD(+) <=> 7,8-dihydromethanopterin + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008177", "l": "succinate dehydrogenase (ubiquinone) activity"}, {"i": "EC:1.3.5.1", "l": "\"Succinate dehydrogenase (quinone)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32838", "l": "4-(trimethylamino)butanoate(in) <=> 4-(trimethylamino)butanoate(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005118", "l": "sevenless binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018620", "l": "phthalate 4,5-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047525", "l": "2'-hydroxydaidzein reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1912372", "l": "Fringe-modified Pre-NOTCH is cleaved by FURIN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2473584", "l": "Collagen type III degradation by MMP15 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41763", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM3 (d18:1(4E)) <=> CMP + ganglioside GD3 (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2889070", "l": "SLC9B2 exchanges Na+, Li+ for H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39886", "l": "dTDP-6-deoxy-alpha-D-allose + NADP(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730599", "l": "Phosphorylated STAT3 Dimer Translocates to the Nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570493", "l": "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015311", "l": "monoamine:proton antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29953", "l": "H(+)(out) + uridine(out) => H(+)(in) + uridine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28441", "l": "dodecanoyl-(Kdo)2-lipid IVA + tetradecanoyl-[ACP] <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43470", "l": "(8Z,10E,14Z)-12-hydroperoxyeicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-434836", "l": "Syk/Lck phosphorylate LAT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052756", "l": "chitobiose phosphorylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033413", "l": "UGU codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23830", "l": "2,5-didehydro-D-gluconate + H(+) + NADPH => 2-dehydro-D-gluconate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "81.790986234327661", "identifiers": [{"i": "GO:0046993", "l": "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor"}, {"i": "EC:1.21.3.-", "l": "\"With oxygen as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388814", "l": "Grb2 binds CD28 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64083", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O <=> 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30617", "l": "2 AH2 + all-trans-zeta-carotene => 15-cis-phytoene + 2 A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964619", "l": "PAK1 binds ARHGEF6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30637", "l": "alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21811", "l": "2,5-dioxopiperazine + H2O <=> glycylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160915", "l": "Receptor-mediated uptake of HA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022315", "l": "MECP2 binds DGCR8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-996755", "l": "ZFPM proteins bind GATA proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036469", "l": "L-tryptophan decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42052", "l": "9-cis-retinol + NAD(+) = 9-cis-retinal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34703", "l": "(2E,6E)-farnesyl diphosphate = (E)-2-epi-beta-caryophyllene + diphosphate"}, {"i": "EC:4.2.3.137", "l": "\"(E)-2-epi-beta-caryophyllene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24358", "l": "a 2-acyl-sn-glycero-3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61263", "l": "H2O + L-glutamine + O2 <=> 2-oxoglutaramate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52994", "l": "[deoxyhypusine synthase]-L-lysine + [eIF5A protein]-N-(4-aminobutylidene)-L-lysine => [deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + [eIF5A protein]-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30988", "l": "(S)-2,3-epoxysqualene => (17Z)-protosta-17(20),24-dien-3beta-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10715", "l": "L-phenylalanine + O2 <=> 2-phenylacetamide + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102963", "l": "(S)-corytuberine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951486", "l": "CD46 binds C4b (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22379", "l": "uridine(38/39/40) in tRNA <=> pseudouridine(38/39/40) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65595", "l": "8-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-171122", "l": "LDL + LDLR => LDL:LDLR complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371537", "l": "DBC1 binds SIRT1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28691", "l": "(S)-dihydroorotate + a ubiquinone = a ubiquinol + orotate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928604", "l": "SFKs phosphorylate VAV2,3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29391", "l": "GTP + H2O = diphosphate + GMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791235", "l": "GADD45A binds AURKA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34815", "l": "2 NADP(+) + tetrahydrocurcumin = curcumin + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.93", "l": "\"Pyrrole-2-carboxylate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56391", "l": "(5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 <=> (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804383", "l": "PRMT5 methylates TP53 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174916", "l": "Formation of N-glucuronides (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23879", "l": "protoaphin aglucone <=> H2O + xanthoaphin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65666", "l": "citrate(in) + 4 Na(+)(in) => citrate(out) + 4 Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77077", "l": "Capping complex formation (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46549", "l": "2 [Fe(II)-cytochrome b5] + a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + 2 H2O + N-acyl-(4E,8E,10E)-sphingatrienine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016517", "l": "interleukin-12 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621402", "l": "Defective CP does not oxidise Fe2+ to Fe3+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31346", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H2O <=> (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20869", "l": "alpha,alpha-trehalose + H2O => 2 D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29715", "l": "2-hydroxyethane-1-sulfonate + FMNH2 + O2 = FMN + glycolaldehyde + 2 H(+) + H2O + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59850", "l": "(S)-tetrahydrodehydrodiconiferyl alcohol + NADP(+) => (2R,3S)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55836", "l": "calcitriol + UDP-alpha-D-glucuronate = calcitriol 25-O-(beta-D-glucuronide) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n14"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5578777", "l": "DMPK phosphorylates PLN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20475", "l": "(R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+) => (R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692550", "l": "Viral inhibitor of caspase-8 activation (UL36) binds caspase-8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0000981", "l": "DNA-binding transcription factor activity, RNA polymerase II-specific"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.7", "l": "\"Ribonuclease P4\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086041", "l": "voltage-gated potassium channel activity involved in SA node cell action potential depolarization"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31153", "l": "2-oxobutanoate + L-selenocysteine + NH4(+) => H2O + L-selenocystathionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65985", "l": "hnu + previtamin D3 => lumisterol 3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69074", "l": "Formation of Processive Complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52454", "l": "16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha-hydroxyestrone + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247840", "l": "WLS binds WNT ligands in the Golgi (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21551", "l": "H2O + N(6)-acetyl-L-lysyl-[alpha-tubulin] <=> acetate + L-lysyl-[alpha-tubulin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28645", "l": "alpha-zingiberene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050081", "l": "maltose-6'-phosphate glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985138", "l": "OAS2 binds viral dsRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202947", "l": "Caspase mediated cleavage of APC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211919", "l": "CYP4F8 19-hydroxylates PGH2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48288", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM3 = CMP + ganglioside GD3 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39970", "l": "2-aminobut-2-enoate <=> 2-iminobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.8", "l": "\"ATP diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54165", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine => a 5'-(N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052608", "l": "echinenone 3-hydroxylase activity"}, {"i": "MetaCyc:RXN-8214"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15062", "l": "2 a Fe(II)-siderophore + H(+) + NAD(+) => 2 a Fe(III)-siderophore + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26021", "l": "beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate => beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018804", "l": "RAC3 GEFs activate RAC3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59452", "l": "a long-chain primary fatty alcohol + NADP(+) = a long-chain fatty aldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161567", "l": "LTB4 is oxidised to 12-oxoLTB4 by PTGR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098620", "l": "seryl-selenocysteinyl-tRNA kinase activity"}, {"i": "REACT:R-HSA-2408507", "l": "Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by PSTK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0005353", "l": "fructose transmembrane transporter activity"}, {"i": "REACT:R-HSA-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176517", "l": "SULTs transfer (SO4)2- group to PREG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71050", "l": "Trimerization of the FASL:FAS receptor complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013006", "l": "RHOA:GTP translocates to the ER membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13684", "l": "a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine <=> a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215295", "l": "USP7 deubiquitinates MDM2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11161", "l": "2-oxoglutarate + L-2,4-diaminobutanoate => L-aspartate 4-semialdehyde + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13759", "l": "(Z)-desulfoglucotropeolin + UDP => (Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66404", "l": "ATP + glutathione(in) + H2O + taurocholate(in) = ADP + glutathione(out) + H(+) + phosphate + taurocholate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877192", "l": "RUNX1 binds FOXP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28526", "l": "(R)-carnitine + crotonobetainyl-CoA = (R)-carnitinyl-CoA + crotonobetaine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40206", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47422", "l": "(2E)-glutaconyl-CoA + AH2 => A + glutaryl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-888577", "l": "Synthesis of GABA by GAD2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953339", "l": "DNPH1 hydrolyses dGMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76031", "l": "2 H2O2 => O2 + 2 H2O (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418091", "l": "F2R binds ARRB1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985153", "l": "OASL binds DDX58 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12559", "l": "6-phospho-D-glucono-1,5-lactone + H2O <=> 6-phospho-D-gluconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050218", "l": "propionate-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45650", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59288", "l": "beta-D-glucosyl-(1<->1)-sphing-4-enine + H2O = D-glucose + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25137", "l": "H2O + pyridoxamine 5'-phosphate => phosphate + pyridoxamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2980720", "l": "NEK9 binds NEK6/NEK7 in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624948", "l": "KIF17 enters the cilium (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15442", "l": "(S)-dihydroorotate + O2 => H2O2 + orotate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013108", "l": "GDIs block activation of RHOC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36969", "l": "3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoA => (10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.12"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9604328", "l": "AKT1 phosphorylates NOTCH4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53048", "l": "2-hydroxyestrone + UDP-alpha-D-glucuronate = 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21234", "l": "NH4(+) + trans-urocanate => L-histidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687875", "l": "Defective SFTPA2 does not translocate from ER membrane to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618093", "l": "ATP hydrolysis by HSP90 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.117", "l": "\"Stratum corneum chymotryptic enzyme\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30440", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + 2 glycyl-tRNA(Gly) => 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205231", "l": "Dimerization of KIT upon SCF binding (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17651", "l": "acetate + malonyl-[ACP] => acetyl-[ACP] + malonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21770", "l": "H(+) + methylamine + NADPH + pyruvate => H2O + N-methyl-L-alanine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191402", "l": "Reduction of presqualene diphosphate to form squalene (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707690", "l": "BACH1 binds MAFK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49421", "l": "ATP + valienone => ADP + H(+) + valienone 7-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395517", "l": "NADPH transfers electrons to FDXR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44555", "l": "1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O <=> H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1467269", "l": "Beta-defensins bind microbial membranes causing disruption (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19776", "l": "NADP(+) + sn-glycerol 3-phosphate <=> D-glyceraldehyde 3-phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102259", "l": "1,2-diacylglycerol acylhydrolase activity"}, {"i": "MetaCyc:RXN-12434"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58673", "l": "D-glucuronate => aldehydo-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158399", "l": "kallikrein binds SERPING1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58059", "l": "hypotaurine + pyruvate <=> 2-sulfinoacetaldehyde + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42075", "l": "(4Z)-2-oxohept-4-enedioate + H2O <=> (4S)-4-hydroxy-2-oxoheptanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14856", "l": "4-chlorobenzoyl-CoA + H2O <=> 4-hydroxybenzoyl-CoA + chloride + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19309", "l": "2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O = (2R)-2-O-(alpha-D-mannosyl)-glycerate + phosphate"}, {"i": "EC:3.1.3.70", "l": "\"Mannosyl-3-phosphoglycerate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19692", "l": "L-rhamnulose 1-phosphate <=> (S)-lactaldehyde + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23946", "l": "4-O-(beta-D-glucosyl)-trans-coniferol + H(+) + UDP => (E)-coniferol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18370", "l": "O2 + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-376141", "l": "Interaction of ABL with ROBO1:SLIT2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33798", "l": "H2O + sucrose <=> alpha-D-glucose + beta-D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28778", "l": "dinoflagellate luciferin + O2 <=> H(+) + H2O + hnu + oxidized dinoflagellate luciferin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65170", "l": "A + H2O + preaustinoid A1 => AH2 + O2 + preaustinoid A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-983147", "l": "Release of E3 from polyubiquitinated substrate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12281", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362437", "l": "C-terminal Hh fragments are bound by lectins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36157", "l": "A + Co-precorrin-4 + S-adenosyl-L-homocysteine => AH2 + Co(II)-factor III + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62922", "l": "1alpha,2beta,25-trihydroxycholecalciferol + 3-hydroxypropanal => 1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20055", "l": "D-ribulose + H(+) + NADH => NAD(+) + ribitol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30570", "l": "5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate <=> 5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60522", "l": "2 glycine + L-cystine => 2 H2O + L-cystine-bis-glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24064", "l": "2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen"}, {"i": "EC:4.2.1.24", "l": "\"Porphobilinogen synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46588", "l": "calciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcidiol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37434", "l": "12,18-didecarboxysiroheme + 2 AH2 + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + 2 A + 2 acetate + Fe-coproporphyrin III + 2 H(+) + 2 L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49564", "l": "D-sedoheptulose 7-phosphate = 2-epi-valiolone + phosphate"}, {"i": "EC:4.2.3.155", "l": "\"2-epi-valiolone synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27788", "l": "CO2 + NADH + succinyl-CoA => 2-oxoglutarate + CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20233", "l": "a 7beta-hydroxysteroid + NADP(+) = a 7-oxosteroid + H(+) + NADPH"}, {"i": "EC:1.1.1.201", "l": "\"7-beta-hydroxysteroid dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033294", "l": "ectoine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38937", "l": "cyclohex-1-ene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein] => cyclohexane-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61604", "l": "[DsbA protein]-dithiol + [DsbB protein]-disulfide = [DsbA protein]-disulfide + [DsbB protein]-dithiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63634", "l": "a long-chain fatty acyl-[ACP] + AMP + H(+) => a long-chain fatty acyl-AMP + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25726", "l": "L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18274", "l": "H2O + O2 + putrescine => 4-aminobutanal + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53085", "l": "[(1->2)-beta-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->2)-beta-D-glucosyl](n+1) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937814", "l": "RUNX3 translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030507", "l": "spectrin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41532", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine"}, {"i": "EC:1.14.16.7", "l": "\"Phenylalanine 3-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174202", "l": "Degradation of multiubiquitinated Securin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37304", "l": "ATP + glycyl-L-asparagine(out) + H2O => ADP + glycyl-L-asparagine(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64289", "l": "2 nataloe emodin + O2 + reduced [NADPH--hemoprotein reductase] => cladofulvin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035597", "l": "N6-isopentenyladenosine methylthiotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943083", "l": "US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28439", "l": "dodecanoyl-(Kdo)2-lipid IVA + tetradecanoyl-[ACP] => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183052", "l": "CBL binds to GRB2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37561", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27556", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 2 isopentenyl diphosphate => all-trans-hexaprenyl diphosphate + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164840", "l": "ADP and Pi bind to ATPase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50051", "l": "ATP + cholate(in) + H2O <=> ADP + cholate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55634", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+) => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53589", "l": "NAD(+) + resolvin D2 => 16-oxoresolvin D2 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44499", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylethanolamine <=> 2-(acylamino)ethyl fatty acid + a monoacyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63213", "l": "5-amino-6-(D-ribitylamino)uracil + methylglyoxal => 5-(2-oxopropylideneamino)-6-(D-ribitylamino)uracil + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27459", "l": "3,5-diiodo-L-tyrosine + H(+) + NADPH => 3-iodo-L-tyrosine + iodide + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5627072", "l": "RHOQ binds GOPC:CFTR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603419", "l": "Activated NTRK3 binds SRC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102950", "l": "indole-3-acetyl-valine synthetase activity"}, {"i": "MetaCyc:RXN-9083"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42352", "l": "(R)-nicotine + A + H2O = (R)-6-hydroxynicotine + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23175", "l": "ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] <=> ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809764", "l": "SBF1 binds MTMR2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69053", "l": "RFC binding displaces Pol Alpha (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.14"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140625", "l": "opioid growth factor receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-112037", "l": "Inactivation of PLC beta (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52126", "l": "(19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008496", "l": "mannan endo-1,6-alpha-mannosidase activity"}, {"i": "REACT:R-HSA-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39242", "l": "(2E)-triacontenoyl-CoA + H(+) + NADPH <=> NADP(+) + triacontanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602147", "l": "Defective CYP2R1 does not 25-hydroxylate vitamin D (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31378", "l": "H(+) + pyrrole-2-carboxylate <=> 1H-pyrrole + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62837", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694435", "l": "MIA2 and MIA3 load procollagen VII into COPII vesicles (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44616", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + H2O = 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450466", "l": "AUF1:mRNA complex is destroyed (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52123", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420121", "l": "SFKs phosphorylate PLCG1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22833", "l": "H2O + N-formimidoyl-L-glutamate => N-formyl-L-glutamate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-947535", "l": "Cyclisation of GTP to precursor Z (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017095", "l": "heparan sulfate 6-O-sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54059", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (2E,6E)-hedycaryol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54537", "l": "a very long-chain fatty acid + ATP + CoA => a very long-chain fatty acyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421218", "l": "xanthosine 5'-monophosphate (XMP) + L-glutamine + ATP + H2O => guanosine 5'-monophosphate (GMP) + L-glutamate + adenosine 5'-monophosphate (AMP) + pyrophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64273", "l": "benzylamine + pyruvate => benzaldehyde + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30373", "l": "(-)-geosmin + acetone => (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30197", "l": "9,9',15-tri-cis-zeta-carotene + plastoquinol-9 => 15,9'-di-cis-phytofluene + plastoquinone-9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59661", "l": "D-cellotetraose + O2 => D-cellotetraono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19314", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684096", "l": "CDK2 phosphorylates RBBP8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46177", "l": "2-methylpropanoate + ATP + CoA => 2-methylpropanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50845", "l": "(5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate => (5S,6S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19896", "l": "4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP <=> 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13172", "l": "maleate <=> fumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16450", "l": "acetyl-CoA + kanamycin B => CoA + H(+) + N(6')-acetylkanamycin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012689", "l": "IL37(1-?) and IL37 (?-) dissocates from IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37196", "l": "octadecanoyl-CoA + sn-glycerol 3-phosphate => 1-octadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168046", "l": "Collagen type XII degradation by MMP12 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944247", "l": "Association of procollagen type VI (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46766", "l": "a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43690", "l": "L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphoenolpyruvate => N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59514", "l": "O-acetyl-L-seryl-[protein] + salicylate => acetylsalicylate + L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26095", "l": "H2O + limonene 1,2-epoxide + NAD(+) => (4R)-limonene + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34800", "l": "2,3-didehydroadipoyl-CoA + acetyl-CoA => 3-oxo-5,6-didehydrosuberyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49248", "l": "galactitol(out) + N(pros)-phospho-L-histidyl-[protein] = galactitol 1-phosphate(in) + L-histidyl-[protein]"}, {"i": "EC:2.7.1.200", "l": "\"Protein-N(pi)-phosphohistidine--galactitol phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.-.-", "l": "\"Isomerases altering macromolecular conformation\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085347", "l": "PIAS1 SUMOylates SAFB with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25853", "l": "2 [Fe(II)-cytochrome b5] + an 11,12-saturated fatty acyl-CoA + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + an (11Z)-Delta(11)-fatty acyl-CoA + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15480", "l": "3'-phosphoadenylyl sulfate + 5beta-scymnol <=> 5beta-scymnol sulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036524", "l": "protein deglycase activity"}, {"i": "MetaCyc:RXN-17634"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62725", "l": "(+)-premalbrancheamide + bromide + FAD + 2 H(+) => (+)-isomalbrancheamide C + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-874087", "l": "SGT1 binds HSP90 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26150", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + NADH => 2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181354", "l": "CERBERUS binds NODAL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29051", "l": "2 H(+)(in) + H2 + menaquinone-8 = 2 H(+)(out) + menaquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24228", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+) = 4-methylcatechol + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59864", "l": "(indol-3-yl)butanoate + ATP + L-glutamine = (indol-3-yl)butanoyl-L-glutamine + AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166726", "l": "Activation of MASPs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70510", "l": "LDH tetramer oxidises LACT to PYR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015922", "l": "aspartate oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112385", "l": "Addition of nucleotides leads to transcript elongation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169421", "l": "Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26493", "l": "a secondary nitroalkane + H2O + O2 <=> a ketone + H(+) + H2O2 + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44882", "l": "ADP + H(+) + O-phospho-L-threonyl-[receptor-protein] => ATP + L-threonyl-[receptor-protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850831", "l": "KLK5 cleaves and activates KLK8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61287", "l": "H2O + L-cystine + O2 <=> (2R)-2-amino-2-carboxylatoethyl-disulfanyl-oxopropanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58005", "l": "(20S)-ginsenoside F2 + UDP-alpha-D-glucose => (20S)-ginsenoside Rd + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51449", "l": "chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] => alpha-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46750", "l": "carbamate + 2 H(+) + phosphate => carboxyphosphate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32250", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) <=> (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046556", "l": "alpha-L-arabinofuranosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033414", "l": "UGC codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25698", "l": "H(+) + N,N-dihydroxy-L-hexahomomethionine = (E)-9-(methylsulfanyl)nonanal oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198599", "l": "AKT phosphorylates MDM2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433456", "l": "Recruitment of STATs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2201293", "l": "Endocytosis of TLR4:LY96:LPS:CD14 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5368586", "l": "DKK promotes clathrin-dependent internalization of LRP6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32830", "l": "ATP + H2O + methionine(out) <=> ADP + H(+) + methionine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080046", "l": "quercetin 4'-O-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-10788"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59930", "l": "D-erythrose + H(+) + NADPH => erythritol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784598", "l": "NPPA(124-151) binds NPR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46499", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(in) <=> N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804527", "l": "INTL1 binds bacterial glycans (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15263", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205652", "l": "Pink1 recruits Parkin to the outer mitochondrial membrane. (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68603", "l": "ORC5 binds ORC2:ORC3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033961", "l": "cis-stilbene-oxide hydrolase activity"}, {"i": "MetaCyc:3.3.2.9-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62871", "l": "9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + NADPH + O2 <=> H2O + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53956", "l": "gamma-L-glutamyl-[BtrI ACP] + H(+) = 4-aminobutanoyl-[BtrI ACP] + CO2"}, {"i": "EC:4.1.1.95", "l": "\"L-glutamyl-[BtrI acyl-carrier protein] decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65378", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidyl-adenosine in mRNA + H(+) + 2 S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidyl-adenosine in mRNA + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809944", "l": "PI(3,5)P2 is dephosphorylated to PI5P by the MTMR2:SBF2 tetramer at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198756", "l": "ERK1/2 phosphorylates MSK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14770", "l": "(S)-nicotine + A + H2O => (S)-6-hydroxynicotine + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807826", "l": "LDHAL6B reduces PYR to LACT (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62565", "l": "(4S)-limonene + A + H2O => (4S)-perillyl alcohol + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55062", "l": "a 12-oxojasmonyl-L-alpha-amino acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => a 12-hydroxyjasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53626", "l": "diphosphate + tsukubadiene => (2E,6E,10E)-geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632670", "l": "CSNK1A1 phosphorylates SMO dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202717", "l": "Heterodimerization of CEACAMs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0019116", "l": "hydroxy-nicotine oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53082", "l": "4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54986", "l": "a ubiquinone + 2 e(-) + 2 H(+) => a ubiquinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34232", "l": "5-nitrosalicylate + O2 => 4-nitro-6-oxohepta-2,4-dienedioate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028524", "l": "NR1H3, NRIP1 bind the PCK1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16856", "l": "N(6)-(1,2-dicarboxyethyl)-AMP <=> AMP + fumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205289", "l": "Autophosphorylation of KIT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24599", "l": "acetyl-CoA + L-histidine <=> CoA + H(+) + N(alpha)-acetyl-L-histidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40318", "l": "glutaryl-CoA + O2 <=> (2E)-glutaconyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14667", "l": "NH4(+) + xanthine => guanine + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42836", "l": "acetyl-CoA + 7 H(+) + 5 malonyl-CoA + 3 NADPH = 5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 4 H2O + 3 NADP(+)"}, {"i": "EC:2.3.1.236", "l": "\"5-methylnaphthoic acid synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2077424", "l": "Point mutants of FGFR2 bind and are inactivated by tyrosine kinase inhibitors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61331", "l": "O2 + parthenolide + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxyparthenolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42467", "l": "biphenyl-2,2',3-triol + O2 <=> 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015161", "l": "lipid III floppase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0015440", "l": "ABC-type peptide transporter activity"}, {"i": "RHEA:14429", "l": "a [oligopeptide](in) + ATP + H2O = a [oligopeptide](out) + ADP + H(+) + phosphate"}, {"i": "EC:7.4.2.6", "l": "\"ABC-type oligopeptide transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603784", "l": "PEX19:class I PMP binds PEX3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15359", "l": "demethyllactenocin + dTDP + H(+) => 5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49970", "l": "17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20213", "l": "L-lysyl-[lipoyl-carrier protein] + N(6)-octanoyl-L-lysyl-[glycine-cleavage complex H protein] = L-lysyl-[glycine-cleavage complex H protein] + N(6)-octanoyl-L-lysyl-[lipoyl-carrier protein]"}, {"i": "EC:2.3.1.204", "l": "\"Octanoyl-[GcvH]:protein N-octanoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005219", "l": "ryanodine-sensitive calcium-release channel activity"}, {"i": "REACT:R-HSA-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39640", "l": "(3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA => (2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29932", "l": "alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP => ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694435", "l": "MIA2 and MIA3 load procollagen VII into COPII vesicles (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15704", "l": "AH2 + all-trans-neurosporene + O2 <=> A + all-trans-lycopene + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52904", "l": "15,17(3)-seco-F430-17(3)-acid + ATP = ADP + coenzyme F430 + phosphate"}, {"i": "EC:6.4.1.9", "l": "\"Coenzyme F(430) synthetase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22427", "l": "an S-alkyl-L-cysteine + H2O <=> an alkyl thiol + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65619", "l": "A + cholest-4-en-3-one + H2O <=> 25-hydroxycholest-4-en-3-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56894", "l": "NADP(+) + UDP-beta-L-rhamnose => H(+) + NADPH + UDP-4-dehydro-beta-L-rhamnose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103037", "l": "L-glyceraldehyde 3-phosphate reductase activity"}, {"i": "MetaCyc:RXN0-5410"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46962", "l": "(2E)-butenoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => butanoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027598", "l": "Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380586", "l": "loading of Serotonin in synaptic vesicles (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13233", "l": "guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16157", "l": "2 [Fe(III)-leghemoglobin] + NADPH = 2 [Fe(II)-leghemoglobin] + H(+) + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34523", "l": "[alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose = [alpha-D-GalNAc-(1->4)]2-[beta-D-Glc-(1->3)]-[alpha-D-GalNAc-(1->4)]2-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + H(+) + UDP"}, {"i": "EC:2.4.1.293", "l": "\"GalNAc(5)-diNAcBac-PP-undecaprenol beta-1,3-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34112", "l": "carboxyspermidine + H2O + NADP(+) => H(+) + L-aspartate 4-semialdehyde + NADPH + putrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32957", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23521", "l": "acetyl-CoA + propanoate => acetate + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36631", "l": "D-ribulose 1,5-bisphosphate + O2 = (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009488", "l": "IL34 binds CSF1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5368586", "l": "DKK promotes clathrin-dependent internalization of LRP6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16203", "l": "4-aminobenzoate + H(+) + pyruvate => 4-amino-4-deoxychorismate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660615", "l": "Defective RB1 does not translocate to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.5.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44541", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090683", "l": "GPCR sweet taste receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5632677", "l": "PTCH is internalized (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785607", "l": "FANCM binds FAAP24 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55650", "l": "CO2 + H(+) + succinate + validoxylamine B => 2-oxoglutarate + O2 + validoxylamine A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51055", "l": "5alpha-androstan-3,17-dione + A <=> 5alpha-androst-1-ene-3,17-dione + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11307", "l": "(S)-ureidoglycolate <=> glyoxylate + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59565", "l": "H2O + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone => H(+) + N,N',N'',N'''-tetraacetylchitotetraonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53915", "l": "butanoyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-butanoyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698007", "l": "FLT3 ITD mutants bind STAT5 through GAB2:PTPN11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873917", "l": "Translocation of STAT1 dimer to nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012689", "l": "IL37(1-?) and IL37 (?-) dissocates from IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24743", "l": "2-aminobut-2-enoate + H2O => 2-oxobutanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39590", "l": "3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10176", "l": "(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+) = (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH"}, {"i": "EC:1.1.1.397", "l": "\"Beta-methylindole-3-pyruvate reductase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102773", "l": "dihydroceramide kinase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0016724", "l": "oxidoreductase activity, acting on metal ions, oxygen as acceptor"}, {"i": "EC:1.16.3.-", "l": "\"With oxygen as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216069", "l": "Interaction of integrin alphaDbeta2 with fibrin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653936", "l": "Formation of Ragulator complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177934", "l": "EGFR autophosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14231", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36362", "l": "2 a plastoquinone + 2 H2O + 4 hnu <=> 2 a plastoquinol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875661", "l": "GGA3 associates with activated MET receptor (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809010", "l": "COPI vesicle uncoating (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63000", "l": "(11Z,14Z,17Z)-eicosatrienamide + H2O = (11Z,14Z,17Z)-eicosatrienoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004475", "l": "mannose-1-phosphate guanylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22991", "l": "3-oxopropanoate + CoA + NADP(+) <=> acetyl-CoA + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61664", "l": "(2E,6E,10E)-geranylgeraniol + ATP = (2E,6E,10E)-geranylgeranyl phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56334", "l": "AMP + ATP + H(+) => 5'-triphosphoadenylyl-(2'->5')-adenosine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46926", "l": "4-methylpent-2-enoyl-CoA + H2O => (R)-2-hydroxy-4-methylpentanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11704", "l": "2 H(+) + N-(carboxyaminomethyl)urea = CO2 + N-(aminomethyl)urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391939", "l": "TP receptor can bind thromboxane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033714", "l": "secondary-alcohol oxidase activity"}, {"i": "RHEA:23180", "l": "a secondary alcohol + O2 = a ketone + H2O2"}, {"i": "EC:1.1.3.18", "l": "\"Secondary-alcohol oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849878", "l": "PSD-95 binds NMDA receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951595", "l": "CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13032", "l": "H2O + N-acetyl-D-glucosamine + O2 <=> H(+) + H2O2 + N-acetyl-D-glucosaminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9649108", "l": "HTR3A pentamer binds 5HT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373717", "l": "DCC interacts with DIP13alpha (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21577", "l": "carnitine + H(+) => 2-methylcholine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60252", "l": "(S)-methylmalonyl-CoA + NADP(+) = acryloyl-CoA + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.64", "l": "\"Inosine diphosphate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28192", "l": "2'-deoxyinosine + NH4(+) => 2'-deoxyadenosine + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987043", "l": "IL22RA1 binds JAK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052639", "l": "salicylic acid glucosyltransferase (ester-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389481", "l": "Orexin 1 receptor can bind orexin-A neuropeptide (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34111", "l": "carboxyspermidine + H2O + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH + putrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36090", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68595", "l": "ORC2 binds ORC3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977228", "l": "Sialyltransferase I can add sialic acid to the T antigen at the alpha 6 position (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30224", "l": "2 [Fe(III)cytochrome c] + hydrogen sulfide => 2 [Fe(II)cytochrome c] + H(+) + sulfur"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725030", "l": "MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13691", "l": "glycerol 1-phosphate + H(+) + phosphate => diphosphate + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39943", "l": "a 1-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34347", "l": "(2E)-geraniol + NAD(+) = (2E)-geranial + H(+) + NADH"}, {"i": "EC:1.1.1.347", "l": "\"Geraniol dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192051", "l": "CYP7A1 7-hydroxylates CHOL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64738", "l": "(E)-4-hydroxynon-2-enal + H(+) + NADPH => 4-hydroxynonanal + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799462", "l": "TP53 family members bind the TP53I3 (PIG3) gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57820", "l": "[phosphate](n) + ADP = [phosphate](n+1) + AMP"}, {"i": "EC:2.7.4.33", "l": "\"AMP-polyphosphate phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29562", "l": "H2O + UDP-alpha-D-glucuronate <=> 1-phospho-alpha-D-glucuronate + 2 H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445448", "l": "HHIP binds Hedgehog (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19100", "l": "AH2 + 2 ATP + benzoyl-CoA + 2 H2O <=> A + 2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.14"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52244", "l": "4 H(+) + 4 Mn(2+) + O2 = 2 H2O + 4 Mn(3+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20496", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine <=> an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851011", "l": "TRIM27 polyubiquitinates PTEN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.2.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001888", "l": "glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity"}, {"i": "RHEA:16221", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}, {"i": "EC:2.4.1.223", "l": "\"Glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27631", "l": "ethylene glycol + NAD(+) => glycolaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177479", "l": "Axonal transport of NGF:Trk complexes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48135", "l": "(2E,6E)-farnesyl phosphate + H2O <=> (2E,6E)-farnesol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61411", "l": "ATP + N(6)-(D-erythrulosyl)-L-lysine <=> ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626817", "l": "PKC phosphorylates NCF1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848150", "l": "STAT3 binds SOCS3 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20591", "l": "(2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein] => glutaryl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-606326", "l": "HJURP:CENPA complex localizes to the centromere (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380048", "l": "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62304", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine = (+)-premalbrancheamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29654", "l": "agmatine(in) + L-arginine(out) <=> agmatine(out) + L-arginine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58300", "l": "25-substituted-cholesterol + beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine = 25-substituted-cholesteryl beta-D-glucoside + N-octadecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69173", "l": "Joining of adjacent Okazaki fragments (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35304", "l": "3-hydroxyisopentadecanoyl-CoA + NADP(+) => 3-oxoisopentadecanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66495", "l": "GDP-alpha-D-mannose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-galctosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675417", "l": "PEBP1 binds activated RAF1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102758", "l": "very-long-chain enoyl-CoA reductase activity"}, {"i": "RHEA:14473", "l": "a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH"}, {"i": "EC:1.3.1.93", "l": "\"Very-long-chain enoyl-CoA reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195275", "l": "Phosphorylation of APC component of the destruction complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549322", "l": "OCT1 transports organic cations out of hepatic cells (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31882", "l": "(S)-2,3-epoxysqualene <=> beta-seco-amyrin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15283", "l": "5alpha-cholest-8-en-3beta-ol => 5alpha-cholest-7-en-3beta-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50204", "l": "(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56486", "l": "gypsogenate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 3 O2 + oleanolate + 3 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350405", "l": "RHOGEF2 binds to RHO1:GDP complex at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47785", "l": "cytidine(3782) in 28S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(3782) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62328", "l": "(+)-isomalbrancheamide B + chloride + FAD + 2 H(+) = (+)-malbrancheamide + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76031", "l": "2 H2O2 => O2 + 2 H2O (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36580", "l": "dTDP-alpha-D-fucose + NAD(+) => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694421", "l": "PP6 dephosphorylates SEC24 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55355", "l": "all-trans-retinol <=> 13-cis-retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24670", "l": "H2O + hypoxanthine + NAD(+) = H(+) + NADH + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-877361", "l": "Pyrin binds ASC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47983", "l": "dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose <=> dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034581", "l": "4-methyloct-2-enoyl-CoA hydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59093", "l": "[(1->3)-alpha-D-glucosyl](n) + sucrose => [(1->3)-alpha-D-glucosyl](n+1) + D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21031", "l": "acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391211", "l": "Trace amine-associated receptors can bind trace amines (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964759", "l": "Alternative endo-mannosidase I route (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052581", "l": "(-)-isopiperitenone reductase activity"}, {"i": "MetaCyc:RXN-5161"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043919", "l": "agmatine aminopropyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55747", "l": "coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75891", "l": "Abortive Initiation After Second Transition (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14631", "l": "ADP + N-acetyl-L-glutamyl 5-phosphate => ATP + N-acetyl-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60019", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + sesquisabinene B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.240", "l": "\"2-polyprenylphenol 6-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31145", "l": "3-oxohexanoyl-CoA + H(+) + NADH => (3S)-hydroxyhexanoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53212", "l": "17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 17beta,18-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46000", "l": "adenosine + H(+) + tuberculosinyl diphosphate = 1-tuberculosinyladenosine + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668904", "l": "Formation of the CTF18 complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004173", "l": "ecdysone O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043210", "l": "alkanesulfonate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38358", "l": "(R)-3-phenyllactoyl-CoA <=> (E)-cinnamoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.-.-", "l": "\"Acting on a sulfur group of donors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59578", "l": "beta-alanine + N(pros)-methyl-L-histidine => anserine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938930", "l": "RUNX1 binds ELF2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23719", "l": "(3Z)-dodecenoyl-CoA <=> (2E)-dodecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21347", "l": "5-hydroxybenzimidazolylcob(I)amide + H(+) + methanol <=> Co-methyl-Co-5-hydroxybenzimidazolylcob(III)amide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59975", "l": "decanoyl-CoA + L-seryl-[protein] <=> CoA + O-decanoyl-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.114", "l": "\"N-acyl-aromatic-L-amino acid amidohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58383", "l": "NADP(+) + nonan-1-ol <=> H(+) + NADPH + nonanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25330", "l": "(R)-carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52388", "l": "ATP + D-threonate = 4-O-phospho-D-threonate + ADP + H(+)"}, {"i": "EC:2.7.1.219", "l": "\"D-threonate 4-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5649856", "l": "Oxidative damage to the AP site (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202203", "l": "Recruitment of PI3K to plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005275", "l": "amine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38747", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-octadecenoyl) ethanolamine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606564", "l": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23221", "l": "4-chlorobenzoate + ATP + CoA => 4-chlorobenzoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5227009", "l": "ABCF1 binds EIF2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102502", "l": "ADP-glucose-starch glucosyltransferase activity"}, {"i": "MetaCyc:RXN-14378"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2990882", "l": "CDK1 phosphorylates NUP98 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990147", "l": "talin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.31", "l": "\"Mycolysin\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106229", "l": "histone glutaryltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218820", "l": "Src kinases phosphorylate VAV (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015317", "l": "phosphate:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61866", "l": "A + probetaenone I => AH2 + dehydroprobetaenone I"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-561072", "l": "OCT3 mediates renal uptake of organic cations (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16337", "l": "a 3'-unsubstituted flavone + O2 + reduced [NADPH--hemoprotein reductase] = a 3'-hydroxyflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.82", "l": "\"Flavonoid 3'-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004013", "l": "adenosylhomocysteinase activity"}, {"i": "RHEA:21708", "l": "H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine"}, {"i": "EC:3.3.1.1", "l": "\"Adenosylhomocysteinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56881", "l": "a 3beta-hydroxy-Delta(5)-steroid + NADP(+) => a 3-oxo-Delta(5)-steroid + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44626", "l": "dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H(+) + NADPH => dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17008", "l": "ATP + D-glucuronate <=> 1-phospho-alpha-D-glucuronate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161282", "l": "Elastic fibres bind associated proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877192", "l": "RUNX1 binds FOXP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18400", "l": "ATP + L-glutamate + tRNA(Glx) <=> AMP + diphosphate + L-glutamyl-tRNA(Glx)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16913", "l": "a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)"}, {"i": "EC:2.7.8.8", "l": "\"CDP-diacylglycerol--serine O-phosphatidyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36991", "l": "phosphate + UMP = alpha-D-ribose 1,5-bisphosphate + uracil"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22289", "l": "an oligoglycosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O => an N-acyl-sphingoid base + an oligoglycosyl-(1->4)-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35626", "l": "D-glutamate + D-glutamine <=> D-gamma-glutamyl-D-glutamate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47739", "l": "cytidine(1404) in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(1404) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35122", "l": "(4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O <=> bisdemethoxycurcumin + CO2 + 2 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940959", "l": "Neurolysin degrades neurotensin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682388", "l": "Autophagosome maturation (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193653", "l": "NGF homodimer binds to p75NTR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10475", "l": "(2R,3S)-2,3-dimethylmalate <=> propanoate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047854", "l": "diguanidinobutanase activity"}, {"i": "KEGG.REACTION:R01418"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10835", "l": "a 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O <=> 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42462", "l": "biphenyl-2,2',3-triol + NAD(+) => dibenzofuran + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43727", "l": "(2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350395", "l": "RHOGDI binds to and sequesters RHO1:GDP complex to the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62162", "l": "N-(9Z-octadecenoyl) ethanolamine + phosphate => H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351876", "l": "Caspase-mediated cleavage of occludin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624132", "l": "UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31152", "l": "H2O + L-selenocystathionine => 2-oxobutanoate + L-selenocysteine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950213", "l": "Expression of Phosphatidylinositol transfer protein alpha isoform (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209074", "l": "WG, FZ and ARR bind to each other (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191654", "l": "c-src associates with Cx43 in gap junctions (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19032", "l": "3 H(+) + H2O + urea-1-carboxylate <=> 2 CO2 + 2 NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5688797", "l": "ATXN3 family cleave Ub chains (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38563", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + H2O = 1-O-hexadecyl-sn-glycerol + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008388", "l": "testosterone 15-alpha-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610270", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN3A (GRIN3A) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17479", "l": "CO2 + 3 H(+) + precorrin-8X + 2 S-adenosyl-L-homocysteine => precorrin-6B + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624494", "l": "RAF1 binds p21 RAS:GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617595", "l": "SGTA binds mislocalized membrane protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3780979", "l": "CCS transfers Cu to SOD1 (mitochondrial) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018746", "l": "RHOQ binds effectors at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73596", "l": "dCMP + H2O => dUMP + NH4+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40895", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606602", "l": "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37286", "l": "H2O + L-alanyl-L-histidine <=> L-alanine + L-histidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17361", "l": "3-oxo-3-ureidopropanoate + H2O = H(+) + malonate + urea"}, {"i": "EC:3.5.1.95", "l": "\"N-malonylurea hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783681", "l": "LIF binds LIFR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40263", "l": "(3R)-hydroxyhexadecanedioyl-CoA + NAD(+) = 3-oxohexadecanedioyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11136", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)"}, {"i": "EC:2.4.99.3", "l": "\"Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46767", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62934", "l": "acetate + cytidine + H(+) => H2O + N(4)-acetylcytidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49606", "l": "2-glutathionyl-2-methylbut-3-enal + H(+) + NADH => 2-glutathionyl-2-methylbut-3-en-1-ol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38911", "l": "avenacoside B + H2O = 26-desgluco-avenacoside B + D-glucose"}, {"i": "EC:3.2.1.188", "l": "\"Avenacosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30678", "l": "tetrahymanol <=> H2O + squalene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983078", "l": "p-STAT3 dissociates from TSLP:IL7R:CRLF2:p-STAT3 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52748", "l": "alpha-isomaltosyl-(1->3)-isomaltose + H2O = 2 isomaltose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350058", "l": "Formation of CSL NCOR corepressor complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375131", "l": "Basigin binds CD98 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10836", "l": "NADPH + O2 + questin = demethylsulochrin + NADP(+)"}, {"i": "EC:1.14.13.43", "l": "\"Questin monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31031", "l": "2-cis-(+)-abscisate + UDP-alpha-D-glucose = beta-D-glucopyranosyl cis-(+)-abscisate + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005324", "l": "long-chain fatty acid transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40699", "l": "1-hexadecanoylglycerone 3-phosphate + octadecan-1-ol = 1-O-octadecylglycerone 3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66689", "l": "4-farnesyl-3,5-dihydroxy-6-methylphthalide + AH2 + 2 O2 => (4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + A + acetone + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17462", "l": "H2O + sedoheptulose 1,7-bisphosphate => D-sedoheptulose 7-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0015234", "l": "thiamine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977363", "l": "Factor H binds to C3bBb (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45481", "l": "gamma-hexachlorocyclohexane => (3R,4S,5S,6R)-pentachlorocyclohexene + chloride + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0062080", "l": "inhibitory MHC class Ib receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17477", "l": "precorrin-6B + 2 S-adenosyl-L-methionine = CO2 + 3 H(+) + precorrin-8X + 2 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.132", "l": "\"Precorrin-6B C(5,15)-methyltransferase (decarboxylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416530", "l": "FFAR1:FFAR1 ligands activates Gq (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869438", "l": "Dissociation of clathrin-associated proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14876", "l": "indole-3-ethanol + NAD(+) <=> H(+) + indole-3-acetaldehyde + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67148", "l": "L-arginine + L-cysteinyl-[NO transferase protein] + NADPH + 2 O2 = 2 H2O + L-citrulline + NADP(+) + S-nitroso-L-cysteinyl-[NO transferase protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102478", "l": "beta-L-arabinofuranosidase activity"}, {"i": "MetaCyc:RXN-14089"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.132"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1250280", "l": "ROS oxidize thioredoxin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004998", "l": "transferrin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2509827", "l": "ITPA hydrolyses ITP to IMP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797554", "l": "ABP1 binds SHANK proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018856", "l": "benzoyl acetate-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205652", "l": "Pink1 recruits Parkin to the outer mitochondrial membrane. (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186785", "l": "PDGF-AA clevage by Furin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50714", "l": "7-chlorotetracycline + FAD + H(+) + 2 H2O => chloride + FADH2 + O2 + tetracycline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50319", "l": "ethyl octadecanoate + H2O <=> ethanol + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202472", "l": "Translocation of TRAF6 to CBM complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938965", "l": "RUNX1 and ELF1, ELF2 or PAX5 bind the BLK gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806957", "l": "MET receptor dimerizes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58612", "l": "2 L-ascorbate + N-octanoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-octanoyl-(2S)-hydroxyglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396594", "l": "Phosphorylation of SLP-76 by p-SYK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483087", "l": "PI is exchanged with PC by PITPNB (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668023", "l": "TPST1,2 transfer SO4(2-) from PAPS to FVIII (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708457", "l": "HM13 cleaves HMOX1 dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614591", "l": "Excess cysteine yields lanthionine and H2S (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47161", "l": "4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) => 4-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33300", "l": "[eIF5A protein]-L-lysine + spermidine => [eIF5A protein]-deoxyhypusine + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39906", "l": "isoxazolin-5-one + O-acetyl-L-serine <=> 3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21985", "l": "3'-phosphoadenylyl sulfate + choline => adenosine 3',5'-bisphosphate + choline sulfate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3772430", "l": "CTNNBIP1 binds beta-catenin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24910", "l": "L,L-cystathionine = 2-aminobut-2-enoate + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43915", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25R)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700168", "l": "Active ALK phosphorylates IRS1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017105", "l": "acyl-CoA delta11-desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25184", "l": "acetyl-CoA + putrescine <=> CoA + H(+) + N-acetylputrescine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047085", "l": "hydroxyphenylacetonitrile 2-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.26"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592314", "l": "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015150", "l": "fucose transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209215", "l": "CI activates transcription (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20844", "l": "ATP + hydrogencarbonate + pyruvate = ADP + H(+) + oxaloacetate + phosphate"}, {"i": "EC:6.4.1.1", "l": "\"Pyruvate carboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17268", "l": "trans-aconitate <=> cis-aconitate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008052", "l": "IL1F10(?-152) binds IL1RAPL1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936985", "l": "Activated TLR4:TICAM1 recruits TRAF6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44143", "l": "CoA + 2 H(+) + oxidized [flavodoxin] + pyruvate <=> acetyl-CoA + CO2 + reduced [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "80.661393760018115", "identifiers": [{"i": "GO:0019763", "l": "immunoglobulin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43916", "l": "(25R)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25R)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43216", "l": "(24S)-hydroxycholesterol + 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine = (24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36084", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + H2O => 1-O-alkyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680811", "l": "nsp12 binds nsp7 and nsp8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32131", "l": "(2S)-ethylmalonyl-CoA + H(+) = butanoyl-CoA + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40415", "l": "H2O + pristanoyl-CoA = 2,6,10,14-tetramethylpentadecanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51787", "l": "4-prenylphlorisovalerophenone + dimethylallyl diphosphate <=> deoxyhumulone + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65929", "l": "3-bromo-2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine => 3-bromo-2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39808", "l": "octadecanoate(in) => octadecanoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56169", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41076", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61219", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23506", "l": "(R)-1-aminopropan-2-ol + adenosylcob(III)yrate => adenosylcob(III)inamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093331", "l": "Ras:GTP binds p120-RasGAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38866", "l": "phosphate + sucrose 6(F)-phosphate <=> alpha-D-glucose 1-phosphate + beta-D-fructose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9625482", "l": "PTK2 binds activated EGFR (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693347", "l": "CRYM reduces P2C to PPCA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25467", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + longifolene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807826", "l": "LDHAL6B reduces PYR to LACT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:1901338", "l": "catecholamine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173680", "l": "Activation of C5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62166", "l": "D-glucosamine + N-acetyl-D-glucosamine => beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65925", "l": "2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine => 2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17565", "l": "myo-inositol + S-adenosyl-L-methionine = 1D-1-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.40", "l": "\"Inositol 1-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62428", "l": "3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA = 3,4-dihydroxybenzaldehyde + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198513", "l": "Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58196", "l": "H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-[histone]"}, {"i": "EC:3.5.1.98", "l": "\"Histone deacetylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426263", "l": "Dystroglycan binds NRXN1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657617", "l": "ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 3-meC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13110", "l": "2-acetamidofluorene + H2O + NAD(+) => H(+) + N-hydroxy-2-acetamidofluorene + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.360", "l": "\"Glucose/galactose 1-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002951", "l": "leukotriene-C(4) hydrolase"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034830", "l": "(2Z)-2,4-dihydroxydec-2-enedioate aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805792", "l": "p-S291-PHF20 translocates to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51722", "l": "AMP(in) + diphosphate(in) + H(+)(in) + octadecanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + octadecanoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66229", "l": "asc-C13-CoA + O2 => asc-DeltaC13-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29805", "l": "ADP + H(+) + L-valine(out) + phosphate => ATP + H2O + L-valine(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047482", "l": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activity"}, {"i": "MetaCyc:6.3.2.7-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72671", "l": "eIF5B:GTP is hydrolyzed and released (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30795", "l": "2-oxoadipate + CoA + NAD(+) = CO2 + glutaryl-CoA + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40069", "l": "3-hydroxy-6-carboxyhexanoyl-CoA + H(+) => 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956639", "l": "RUNX1 binds YAP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538900", "l": "Phosphorylated PER rebinds to phosphorylated TIM (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-982765", "l": "Growth hormone forms dimers and oligomers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60855", "l": "a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139899", "l": "Sequestration of BAD protein by 14-3-3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200646", "l": "Cytosolic folate export across the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426489", "l": "RISC binds inexactly matching target RNAs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54222", "l": "all-trans-neurosporene + H2O => 1-hydroxy-all-trans-1,2-dihydro-neurosporene"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140032", "l": "glycosylation-dependent protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451942", "l": "Within the IL-2R complex JAK3 phosphorylates JAK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45199", "l": "5,6,7,8-tetrahydrosarcinapterin + [methyl-Co(III) corrinoid Fe-S protein] <=> 5-methyltetrahydrosarcinapterin + [Co(I) corrinoid Fe-S protein] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26283", "l": "acetaldehyde + Co-precorrin-5B + H(+) => Co-precorrin-5A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60259", "l": "A + H2O + N(6)-methyl-L-lysyl(4)-[histone H3] <=> AH2 + formaldehyde + L-lysyl(4)-[histone H3]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047850", "l": "diaminopimelate dehydrogenase activity"}, {"i": "RHEA:13561", "l": "H2O + meso-2,6-diaminoheptanedioate + NADP(+) = (S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+)"}, {"i": "EC:1.4.1.16", "l": "\"Diaminopimelate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050163", "l": "oxaloacetate tautomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22481", "l": "4-(hydroxyamino)quinoline N-oxide + H2O + 2 NAD(+) => 4-nitroquinoline N-oxide + 2 H(+) + 2 NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950354", "l": "STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62650", "l": "(5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate => (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55884", "l": "[aequorin] + 3 Ca(2+) = [aequorin]--dioxetanone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41106", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11347", "l": "an N-acylneuraminate + CTP <=> a CMP-N-acyl-beta-neuraminate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55646", "l": "ADP + C-terminal S-cyanate-L-cysteinyl-[HypE protein] + H(+) + phosphate => ATP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-996727", "l": "REST recruits the BHC complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29517", "l": "alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+) => beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432067", "l": "Aquaporin-4 passively transports water out of cell (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51212", "l": "(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19049", "l": "(5R)-5-hydroxy-L-lysine + GTP = (5R)-5-phosphooxy-L-lysine + GDP + H(+)"}, {"i": "EC:2.7.1.81", "l": "\"Hydroxylysine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28283", "l": "(S)-beta-bisabolene => (S)-beta-macrocarpene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173725", "l": "C9 binds C5b:C6:C7:C8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16927", "l": "(E)-feruloyl-CoA + H(+) + S-adenosyl-L-homocysteine => (E)-caffeoyl-CoA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-877361", "l": "Pyrin binds ASC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362549", "l": "Hh-Np traffics to the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399939", "l": "Autophosphorylation of PAK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103009", "l": "3-chlorotoluene monooxygenase activity"}, {"i": "MetaCyc:RXN-9908"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851908", "l": "Activated MET binds GAB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54013", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210805", "l": "Removal of miRNA passenger strand (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15440", "l": "a long-chain fatty aldehyde + CoA + NADP(+) <=> a long-chain fatty acyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68688", "l": "CDC6 association with ORC:origin complexes mediated by MCM8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678327", "l": "MIOX oxidises Ins to GlcA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45424", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42551", "l": "uridine(746) in 23S rRNA <=> pseudouridine(746) in 23S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12534", "l": "coenzyme M-coenzyme B heterodisulfide + methane => coenzyme B + methyl-coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-350598", "l": "Arginine<=>Agmatine+CO2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42139", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52055", "l": "9-hexadecanoyloxy-octadecanoate + H2O <=> 9-hydroxy-octadecanoate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507875", "l": "Aquaporins passively transport urea into cells (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0030368", "l": "interleukin-17 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000120", "l": "CBLIF binds Cbl (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61812", "l": "3beta-hydroxyandrost-5-en-17-one + UDP-alpha-D-glucose = dehydroepiandrosterone 3-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61277", "l": "H2O + L-ornithine + O2 => 5-amino-2-oxopentanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44758", "l": "6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-heptaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41726", "l": "(11R)-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24189", "l": "cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) => 1,2-dihydroxydibenzothiophene + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030612", "l": "arsenate reductase (thioredoxin) activity"}, {"i": "MetaCyc:RXN-10737"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008412", "l": "CDK4 phosphorylates RUNX2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814387", "l": "CASP14 cleaves filaggrin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798743", "l": "Exocytosis of secretory granule membrane proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694583", "l": "ABHD4 hydrolyses NAPE (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669893", "l": "KIT binds type I TKIs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693783", "l": "NAALADases hydrolyse NAAG (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21844", "l": "L-glutamine + phenylacetyl-CoA = CoA + H(+) + N(2)-phenylacetyl-L-glutamine"}, {"i": "EC:2.3.1.14", "l": "\"Glutamine N-phenylacetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55028", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + S-adenosyl-L-methionine = an N-methylornithine lipid + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47308", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74730", "l": "Insulin degradation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102733", "l": "typhasterol C-23 hydroxylase activity"}, {"i": "MetaCyc:RXN-719"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465883", "l": "VTN binds collagens I, IV and VI (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928617", "l": "EPHB2 binds KALRN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052753", "l": "propan-2-ol:coenzyme F420 oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58920", "l": "(3S,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol = (+)-medicarpin + H2O"}, {"i": "EC:4.2.1.139", "l": "\"Pterocarpan synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18695", "l": "6-aminopenicillanate + a carboxylate => H2O + penicillin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35844", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-3-phosphoethanolamine + a cardiolipin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684882", "l": "CHEK1 is recruited to resected DNA DSBs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097626", "l": "low-affinity L-arginine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17177", "l": "(R)-carnitine + octanoyl-CoA = CoA + O-octanoyl-(R)-carnitine"}, {"i": "EC:2.3.1.137", "l": "\"Carnitine O-octanoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866857", "l": "CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53216", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha,17alpha-dihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55690", "l": "1D-myo-inositol 1-phosphate + an N-acyl-(4R)-4-hydroxysphinganine + H(+) => an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17305", "l": "H2O + N(omega),N(omega)-dimethyl-L-arginine = dimethylamine + L-citrulline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12827", "l": "[thioredoxin]-dithiol + H(+) + phosphate + sarcosine => [thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28910", "l": "3-(3-hydroxyphenyl)propanoate(in) + H(+)(in) <=> 3-(3-hydroxyphenyl)propanoate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61885", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-9-hydroperoxy-20-hydroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103020", "l": "1-deoxy-D-xylulose kinase activity"}, {"i": "RHEA:27990", "l": "1-deoxy-D-xylulose + ATP = 1-deoxy-D-xylulose 5-phosphate + ADP + H(+)"}, {"i": "MetaCyc:RXN0-382"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27950", "l": "L-phenylalanine(in) = L-phenylalanine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28918", "l": "4-aminobutanoate(in) + H(+)(in) <=> 4-aminobutanoate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029273", "l": "PI3K binds to p-6Y-SYK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56668", "l": "7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) = 7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}, {"i": "EC:1.3.1.116", "l": "\"7-beta-hydroxy-3-oxochol-24-oyl-CoA 4-desaturase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043854", "l": "cyclic nucleotide-gated mechanosensitive ion channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788623", "l": "p-Y-STATs translocate to nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662613", "l": "MT3 exchanges zinc for copper (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53324", "l": "2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin E2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164834", "l": "Enzyme-bound ATP is released (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001604", "l": "urotensin II receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853317", "l": "FGFR3 fusions dimerize (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013145", "l": "RAC1 binds effectors at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56437", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O => 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392195", "l": "Gi activation by P2Y purinoceptor 12 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109702", "l": "PDPK1 phosphorylates AKT2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55005", "l": "1-hydroxylimonen-2-one + NADPH + O2 => 3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.98"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009488", "l": "IL34 binds CSF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050099", "l": "methylglutamate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608825", "l": "DVL2 is phosphorylated after WNT5A binding to FZD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191636", "l": "Phosphorylation of Cx43 by c-src (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19947", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156915", "l": "Translocation of ribosome by 3 bases in the 3' direction (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1878002", "l": "XYLTs transfer Xyl to core protein (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085083", "l": "Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784765", "l": "p-Y705-STAT3 dimerizes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12402", "l": "NH4(+) + nicotinate beta-D-ribonucleotide => beta-nicotinamide D-ribonucleotide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64156", "l": "an N-(fatty acyl)-L-methionine + H2O = a fatty acid + L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030550", "l": "acetylcholine receptor inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27581", "l": "(R)-N-tert-butylpiperazine-2-carboxamide + H2O <=> (R)-piperazine-2-carboxylate + tert-butylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2426566", "l": "Interaction of DAP12 and CLM7 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.69", "l": "\"Bontoxilysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806732", "l": "GNLY binds the bacterial cell surface (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25594", "l": "2-oxoglutarate + H(+) + isochorismate => 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106256", "l": "hydroperoxy icosatetraenoate dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57493", "l": "H2O + oxaloacetate + propanoyl-CoA => 2-methylcitrate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-427570", "l": "Group 3 - Selective Cl- transport (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018509", "l": "cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49884", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17426", "l": "CoA + NADP(+) + pyruvate => acetyl-CoA + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20079", "l": "2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(18) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013284", "l": "NOTCH3-ligand complex is cleaved to produce NEXT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41744", "l": "3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol = a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357483", "l": "RAC1 binds PAK1-3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034782", "l": "dimethylmalonate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202724", "l": "P-selectin binds P-selectin ligand (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350147", "l": "VD3 translocates from extracellular region to ER membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34494", "l": "H2O + UDP-N,N'-diacetylbacillosamine <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53469", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine + cholesterol => (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034895", "l": "pyridine-3,4-diol dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31347", "l": "(+)-abscisic acid D-glucopyranosyl ester + H2O = 2-cis-(+)-abscisate + beta-D-glucose + H(+)"}, {"i": "EC:3.2.1.175", "l": "\"Beta-D-glucopyranosyl abscisate beta-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36076", "l": "AH2 + an N-acylsphinganine + O2 => A + an N-acylsphing-4-enine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60978", "l": "(E)-4-hydroxynon-2-enal + H(+) + NADH => (E)-4-hydroxynon-2-en-1-ol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3878123", "l": "Initiation of SAHF formation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48160", "l": "3 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] = epoxypheophorbide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65576", "l": "a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + UDP-alpha-D-glucuronate = an alpha-D-glucuronosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49431", "l": "CTP + phosphonoformate <=> CMP-5'-phosphonoformate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.26", "l": "\"Prolyl oligopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61849", "l": "cholesterol + UDP-alpha-D-glucose => cholesteryl 3-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009282", "l": "CDK1 phosphorylates RUNX2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41182", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31418", "l": "(2Z,6E)-farnesyl diphosphate <=> (+)-2-epi-prezizaene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41011", "l": "(+)-sesamin + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n = (+)-sesamin monocatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17682", "l": "3-hydroxy-2-methylpropanoate + NAD(+) => 2-methyl-3-oxopropanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14384", "l": "4-guanidinobutanal + H2O + NAD(+) <=> 4-guanidinobutanoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033934", "l": "glucan 1,4-alpha-maltotriohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29952", "l": "H(+)(in) + uridine(in) => H(+)(out) + uridine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40925", "l": "(9Z)-octadecenoate + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39159", "l": "(3R)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56905", "l": "an acyl-AMP + CoA => AMP + an acyl-CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112514", "l": "JAK activation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-947531", "l": "Molybdenum ion transfer onto molybdopterin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15924", "l": "2 a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol <=> a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a 1,2-diacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30249", "l": "O2 + 2 plastoquinol-9 => 2 H2O + 4 hnu + 2 plastoquinone-9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44303", "l": "2 H(+) + malonyl-CoA + methylmalonyl-CoA + octadecanoyl-CoA <=> 4-hydroxy-5-methyl-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40897", "l": "(9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63388", "l": "2 A + Fe(II)-heme o + H2O = 2 AH2 + Fe(II)-heme a"}, {"i": "EC:1.17.99.9", "l": "\"Heme a synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66523", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60091", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NADP(+) <=> a 4alpha-methyl-3-oxosteroid + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204871", "l": "Interaction of Tie2 and Grb2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51166", "l": "5-methylcytidine(61) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(61) in tRNA(Asp) + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803890", "l": "SFN dimerizes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042609", "l": "CD4 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928625", "l": "PAKs autophosphorylate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36556", "l": "eicosanoyl-CoA + sphinganine => CoA + H(+) + N-eicosanoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102278", "l": "N,N'-diacetylchitobiose synthase activity"}, {"i": "MetaCyc:RXN-12554"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16542", "l": "9-cis-violaxanthin + O2 => (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23982", "l": "linear maltodextrin => cyclomaltodextrin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19259", "l": "a ketone + H(+) + NADPH => a secondary alcohol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036383", "l": "3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase activity"}, {"i": "MetaCyc:1.14.14.12-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40621", "l": "2,3-didodecanoyl-sn-glycerol + dodecanoate + H(+) => H2O + tridodecanoylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29976", "l": "2'-deoxycytidine(in) + H(+)(in) => 2'-deoxycytidine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14622", "l": "(S)-2,3-epoxysqualene => lanosterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21625", "l": "FMNH2 + NADP(+) => FMN + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48826", "l": "a lactoside III(4)-a-Fuc-Lc4Cer + GDP + H(+) => GDP-beta-L-fucose + Lc4Cer"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18877", "l": "myo-inositol + S-adenosyl-L-methionine = 1D-3-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.39", "l": "\"Inositol 3-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0001016", "l": "RNA polymerase III transcription regulatory region sequence-specific DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13189", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+)"}, {"i": "EC:3.1.1.26", "l": "\"Galactolipase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35830", "l": "H2O + N(1)-aminopropylagmatine <=> spermidine + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36201", "l": "1-O-(1Z-alkenyl)-sn-glycerol + H(+) + phosphoethanolamine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63271", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + O2 <=> 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25842", "l": "5-dehydro-2-deoxy-D-gluconate => 5-deoxy-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193668", "l": "p75NTR and RHOA-GDI interact (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-141423", "l": "Binding of the MCC complex to the APC/C complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55038", "l": "an N,N,N-trimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine => an N,N-dimethylornithine lipid + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55986", "l": "(R)-prunasin + H(+) + UDP => (R)-mandelonitrile + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54429", "l": "4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O => ADP-D-ribose + H(+) + L-aspartyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38919", "l": "H2O + sphing-4-enine-phosphocholine = choline + H(+) + sphing-4-enine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15560", "l": "ATP + H2O + Ni(2+)(out) <=> ADP + H(+) + Ni(2+)(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382054", "l": "PDGF binds to extracellular matrix proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983158", "l": "Trimming of peptides in ER (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033816", "l": "diaminobutyrate acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18277", "l": "a thiol + S-adenosyl-L-methionine = a methyl thioether + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.9", "l": "\"Thiol S-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448702", "l": "Caspase-1 active tetramer formation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15692", "l": "H(+) + L-2,4-diaminobutanoate <=> CO2 + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2984226", "l": "PLK1 phosphorylates NEK9 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-453338", "l": "PGYM b dimer:AMP complex <=> PGYM dimer, b form + 2 AMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354097", "l": "Activation of Talin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9656947", "l": "OGG1beta translocates to mitochondria (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23359", "l": "ATP + L-seryl-[rhodopsin] <=> ADP + H(+) + O-phospho-L-seryl-[rhodopsin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45306", "l": "1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102940", "l": "phloroglucinol O-methyltransferase activity"}, {"i": "MetaCyc:RXN-9020"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44472", "l": "1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-alkyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36045", "l": "13-apo-beta-carotenone + 2,6-dimethyldeca-2,4,6,8-tetraenedial => all-trans-8'-apo-beta-carotenal + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62073", "l": "D-galactose 6-phosphate + NADP(+) => 6-phospho-D-galactono-1,5-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607733", "l": "BCL10 binds CARD9 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982017", "l": "Active G alpha (q) binds RGS proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022141", "l": "Prolysyl oxidase activation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419843", "l": "CALCA(83-119) binds CALCR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15452", "l": "homogentisate + O2 <=> 4-maleylacetoacetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52352", "l": "(24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630047", "l": "Defective NTHL1 truncation mutants do not bind cytosine glycol (Cg) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876993", "l": "CBLL1 binds SRC-phosphorylated CDH1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34004", "l": "5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH + O2 => cholesta-5,7,24-trien-3beta-ol + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004653", "l": "polypeptide N-acetylgalactosaminyltransferase activity"}, {"i": "MetaCyc:2.4.1.41-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58869", "l": "24-methylidenelophenol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693722", "l": "Unknown sepiapterin synthase transforms PTHP to sepiapterin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29080", "l": "(R)-lactate + ubiquinone-8 => pyruvate + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5159250", "l": "ATF7IP binds SETDB1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168136", "l": "Activated JNKs phosphorylate c-JUN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5683925", "l": "ULK1 is dephosphorylated (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190519", "l": "Internalization of gap junction plaques (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45081", "l": "3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine => ADP + dapdiamide E + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51895", "l": "H2O + N-acetylcadaverine <=> acetate + cadaverine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41216", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44744", "l": "4 H(+) + 4 malonyl-CoA = (3,5-dihydroxyphenyl)acetyl-CoA + 4 CO2 + 3 CoA + H2O"}, {"i": "EC:2.3.1.246", "l": "\"3,5-dihydroxyphenylacetyl-CoA synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47408", "l": "(24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O = (24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0098988", "l": "G protein-coupled glutamate receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655170", "l": "RCHY1 monoubiquitinates POLH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0098518", "l": "polynucleotide phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34378", "l": "4-guanidinobutanamide + H2O <=> 4-guanidinobutanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44552", "l": "1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O = H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114683", "l": "Phosphorylation of Platelet Sec-1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803719", "l": "TP53 binds ZNF385A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65755", "l": "2-oxoglutarate + L-glutamate + O2 <=> (3R)-3-hydroxy-L-glutamate + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018632", "l": "4-nitrophenol 4-monooxygenase activity"}, {"i": "RHEA:34327", "l": "4-nitrophenol + H(+) + NADPH + O2 = 1,4-benzoquinone + H2O + NADP(+) + nitrite"}, {"i": "EC:1.14.13.167", "l": "\"4-nitrophenol 4-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56861", "l": "a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate => a 2-oxo-3-(phosphooxy)propyl medium-chain 3-oxoalkanoate + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3858482", "l": "DVL is recruited to the receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12276", "l": "3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43496", "l": "L-gulonate + NAD(+) = H(+) + keto-D-fructuronate + NADH"}, {"i": "EC:1.1.1.380", "l": "\"L-gulonate 5-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59269", "l": "A + H2O + N(6)-methyl-L-lysyl-[protein] => AH2 + formaldehyde + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8858428", "l": "FCAMR binds IgA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030848", "l": "threo-3-hydroxyaspartate ammonia-lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38915", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420233", "l": "VIP receptors bind VIP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34956", "l": "5-(methylsulfanyl)-D-ribose(in) => 5-(methylsulfanyl)-D-ribose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47217", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxyestradiol-17beta + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10927", "l": "cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide <=> trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047727", "l": "isobutyryl-CoA mutase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.5", "l": "\"Exodeoxyribonuclease V\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43050", "l": "keto-D-sorbose => keto-D-tagatose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55432", "l": "11-hydroxyferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = carnosate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.61", "l": "\"Carnosic acid synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21849", "l": "(E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide => (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002145", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38020", "l": "(9Z)-octadecenoyl-CoA + 1-decanoylglycerol => 1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046180", "l": "KSPG is secreted from the cell (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42274", "l": "5-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA => 3-methylbutanoyl-CoA + H(+) + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41296", "l": "H2O + N-(hexanoyl)sphing-4-enine => hexanoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428888", "l": "Phosphorylation of ROBO1 by ABL kinase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176318", "l": "Loading of claspin onto DNA during replication origin firing (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696266", "l": "RND2 binds effectors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114352", "l": "Sequestration of tBID by BCL-2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47829", "l": "ganglioside GT1b + H2O => ganglioside GD1b + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654511", "l": "FGFRL1 dimer binds FGFs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31840", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-3-dehydro-6-deoxy-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19288", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + di-trans,poly-cis-dolichol <=> a 1-acyl-sn-glycero-3-phosphocholine + acyldolichol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28608", "l": "(E)-2-methylpropanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-valine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0015631", "l": "tubulin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47869", "l": "di-(9Z)-octadecenoylglycerol + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694630", "l": "Nsp3:nsp4 binds to nsp6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-917696", "l": "Cargo Sequestration (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-593685", "l": "Netrin-4 binds DCC/UNC5A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428749", "l": "Activated TP receptor binds G-proten Gq (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46769", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-acyl-2-[(9Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964284", "l": "BTK in active Gq-BTK complex is activated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381435", "l": "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655326", "l": "Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36541", "l": "CoA + H(+) + N-hexadecanoylsphinganine => hexadecanoyl-CoA + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44588", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-1D-myo-inositol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44178", "l": "3-acyl-sn-glycerol + a fatty acid + H(+) => a 2,3-diacyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49837", "l": "(5E)-tetradecenoyl-CoA + (R)-carnitine => (5E)-tetradecenoyl-(R)-carnitine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26256", "l": "H(+) + isopimara-7,15-dienol + NADPH + O2 <=> 2 H2O + isopimara-7,15-dienal + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003875", "l": "ADP-ribosylarginine hydrolase activity"}, {"i": "EC:3.2.2.19", "l": "\"[Protein ADP-ribosylarginine] hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706304", "l": "Active FLT3 binds to GRAP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23751", "l": "ATP + GTP <=> diphosphate + pppGp(2'-5')A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35752", "l": "ATP + kanosamine => ADP + D-kanosamine 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37953", "l": "(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38220", "l": "(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52407", "l": "3-dehydro-4-O-phospho-L-erythronate + H(+) <=> CO2 + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57705", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+) => 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54783", "l": "[LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine <=> [LarE protein]-dehydroalanine + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451283", "l": "kainate receptor binds glutamate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55064", "l": "4-methylpentanoyl-CoA + H2O = 4-methylpentanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58423", "l": "NADP(+) + prenol <=> 3-methyl-2-butenal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653754", "l": "UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51682", "l": "(2E,6E)-farnesyl phosphate + CDP + H(+) => (2E,6E)-farnesol + CTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983422", "l": "Disassembly of COPII coated vesicle (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52615", "l": "3-(methylsulfanyl)propanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> 3-(methylsulfanyl)acryloyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871265", "l": "YAP1 binds TEAD4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675656", "l": "EDA:EDAR binds EDARADD (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6813626", "l": "LEAP2 binds bacteria (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20814", "l": "acetyl-CoA + oxaloacetate => (3S)-citryl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004941", "l": "beta2-adrenergic receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55233", "l": "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 [Fe(II)-cytochrome b5] + H(+) + O2 => 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 2 [Fe(III)-cytochrome b561] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34913", "l": "D-methionine(out) => D-methionine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56849", "l": "1,6-didemethyltoxoflavin + S-adenosyl-L-methionine => H(+) + reumycin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685606", "l": "CLEC2D binds KLRB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10517", "l": "(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) => (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429101", "l": "HMIT co-transports myo-inositol with a proton (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873926", "l": "IFNG dimer binds IFNGR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62097", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 2-(9Z-octadecenoyl)-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37808", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015530", "l": "shikimate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187382", "l": "Degradation of ubiquitinated SMAD3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51509", "l": "2-oxoglutarate + L-proline + O2 => CO2 + succinate + trans-4-hydroxy-L-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45154", "l": "3-oxopropanoyl-CoA + methanethiol => 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938913", "l": "RUNX1 binds ELF1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55414", "l": "[phosphate](n+1) + GDP => [phosphate](n) + GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23535", "l": "ATP + cholate + CoA <=> AMP + choloyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16616", "l": "acetyl-CoA + an arylamine <=> an N-acetylarylamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111966", "l": "GRK2 binds CALM1:4Ca2+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20937", "l": "2,3-dihydroxy-3-methylbutanoate => 3-methyl-2-oxobutanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5692764", "l": "MAPK6 binds CCND3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198714", "l": "ERK5 translocates to the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1980051", "l": "DLL4 binds NOTCH2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1605797", "l": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0034701", "l": "tripeptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52845", "l": "3,4-dihydroxybenzoate + UDP-alpha-D-glucose => 1-O-(3,4-dihydroxy-benzoyl)-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395320", "l": "Latent TGF-beta-1 binds integrins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340124", "l": "CSN polymer binds CaPO4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30876", "l": "2-oxoglutarate + D-lysine => 6-amino-2-oxohexanoate + D-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53629", "l": "(2E,6E)-farnesyl diphosphate => (2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354173", "l": "Activation of Rap1 by cytosolic GEFs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13384", "l": "acetate + an acyl-CoA <=> a carboxylate + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32773", "l": "2,6-dioxo-6-phenylhexa-3-enoate => 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51164", "l": "cytidine(61) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(61) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353300", "l": "MGMT mediated DNA Damage Reversal (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10919", "l": "(1R,2R,3R)-prephytoene diphosphate <=> all-trans-phytoene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445064", "l": "Activation of Rac1 by VAV2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8980691", "l": "RHOA GEFs activate RHOA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164423", "l": "PhosphoChREBP (Thr 666)  is exported to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182171", "l": "Degradation of CD8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2134519", "l": "TGFBR2 is recruited to tight junctions after TGF-beta stimulation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390595", "l": "Calcium Binds Troponin-C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62065", "l": "2-deoxy-D-glucose 6-phosphate + NAD(+) => 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8856525", "l": "ANGPTL8 binds ANGPTL3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015927", "l": "trehalase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54919", "l": "9-cis-retinol + NADP(+) <=> 9-cis-retinal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322422", "l": "Beta-catenin recruits SMARCA4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22501", "l": "(E)-feruloyl-CoA + H(+) + malonyl-CoA => (E)-feruloylacetyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373141", "l": "malate <=> fumarate + H2O (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61294", "l": "2-dehydropantoate + H(+) + NADH => (R)-pantoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45410", "l": "dodecanoyl-CoA + NAD(+) => (2E)-dodecenoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25405", "l": "(S)-2-ethyl-2-hydroxy-3-oxobutanoate => (R)-3-hydroxy-3-methyl-2-oxopentanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004045", "l": "aminoacyl-tRNA hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216082", "l": "Interaction of integrin alphaXbeta2 with fibrin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444661", "l": "HCAR2 binds HCAR2 ligands (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374662", "l": "Translocation of Ezrin to plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53323", "l": "alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose <=> alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53151", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102066", "l": "alpha-patchoulene synthase activityy"}, {"i": "MetaCyc:RXN-10603"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.47", "l": "\"Acyl-lipid (9-3)-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28206", "l": "2'-deoxyuridine + ATP = ADP + dUMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33936", "l": "2 N(omega)-hydroxy-L-arginine + NADH + 2 O2 => H(+) + 2 H2O + 2 L-citrulline + NAD(+) + 2 nitric oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29243", "l": "H(+) + menaquinone-8 + NADH = menaquinol-8 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0016421", "l": "CoA carboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33234", "l": "H2O2 + heme b <=> heme d cis-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54037", "l": "[mycoredoxin]-L-cysteine + arseno-mycothiol + H(+) => [mycoredoxin]-S-mycothiol-L-cysteine + arsenite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19928", "l": "D-ribitol 5-phosphate + NAD(+) <=> D-ribulose 5-phosphate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53840", "l": "3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADP(+) = 7,12-dioxo-lithocholate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149434", "l": "Transport of GAG to the Plasma Membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209102", "l": "SLMB binds to phosphorylated ARM to form the 'destruction complex' (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617583", "l": "CaMKII autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35980", "l": "dimethylallyl diphosphate + verruculogen => diphosphate + fumitremorgin A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54365", "l": "2 acetaldehyde => acetoin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047513", "l": "1,2-alpha-L-fucosidase activity"}, {"i": "MetaCyc:12-ALPHA-L-FUCOSIDASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22375", "l": "H2O + O2 + propionate 3-nitronate <=> 3-oxopropanoate + H(+) + H2O2 + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45813", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA => a very-long-chain (2E)-enoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981622", "l": "Myoglobin:oxygen dissociates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093331", "l": "Ras:GTP binds p120-RasGAP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709360", "l": "H2O2 reduces MetHb (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4837364", "l": "Secretion of SOD3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088207", "l": "Golgi lumen glycoconjugates translocate to the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15027", "l": "7-methylxanthosine + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + xanthosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49237", "l": "N(pros)-phospho-L-histidyl-[protein](out) + sucrose => L-histidyl-[protein] + sucrose 6(G)-phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46669", "l": "21-hydroxyprogesterone + H(+) + NADPH => 5beta-dihydrodeoxycorticosterone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034904", "l": "5-chloro-2-oxopent-4-enoate hydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44946", "l": "1-O-alkyl-sn-glycerol + a fatty acid + H(+) => 1-O-alkyl-3-acyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381461", "l": "Plasmin proteolyzes IGF:IGFBP-3:ALS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48767", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD(+) <=> 3-acetyl-3-devinylchlorophyllide a + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61787", "l": "L-allulose <=> keto-L-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44962", "l": "decanoyl-CoA + NADP(+) => (2E)-decenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0005326", "l": "neurotransmitter transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27530", "l": "(2E,6E)-farnesyl diphosphate + H2O = (3S,6E)-nerolidol + diphosphate"}, {"i": "EC:4.2.3.48", "l": "\"(3S,6E)-nerolidol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2032781", "l": "WWTR1 (TAZ) binds TEAD (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16081", "l": "(2R)-S-methyl-3-phospho-1-thioglycerate + H2O = (2R)-S-methyl-1-thioglycerate + phosphate"}, {"i": "EC:3.1.3.14", "l": "\"Methylphosphothioglycerate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45823", "l": "mesaconate + succinyl-CoA <=> 2-methylfumaryl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354073", "l": "Autophosphorylation of PTK2 at Y397 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45444", "l": "H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphoethanolamine = H(+) + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14065", "l": "scyllo-inosose = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O"}, {"i": "EC:4.2.1.44", "l": "\"Myo-inosose-2 dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41265", "l": "15-keto-prostaglandin A1 + H(+) + NADH => NAD(+) + prostaglandin A1"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030738", "l": "tyramine N-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34693", "l": "acryloyl-CoA + H2O => (R)-lactoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682992", "l": "KDM4A,B bind H4K20Me2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21836", "l": "D-arabinonate = 2-dehydro-3-deoxy-D-arabinonate + H2O"}, {"i": "EC:4.2.1.5", "l": "\"Arabinonate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099119", "l": "3-demethylubiquinol-8 3-O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73596", "l": "dCMP + H2O => dUMP + NH4+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61063", "l": "beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + UDP-alpha-D-galactose <=> a neolactoside nLc4Cer + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617413", "l": "Expression of GLI2 is repressed by GLI3R in the absence of Hh signaling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32113", "l": "3-methoxy-4',5-dihydroxy-trans-stilbene + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + trans-resveratrol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5684006", "l": "KPNA2 translocates NBN to the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24836", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate"}, {"i": "EC:6.3.4.23", "l": "\"Formate--phosphoribosylaminoimidazolecarboxamide ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20284", "l": "3'-phosphoadenylyl sulfate + desulfoglucotropeolin <=> adenosine 3',5'-bisphosphate + glucotropeolin + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12344", "l": "(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH"}, {"i": "EC:1.2.1.70", "l": "\"Glutamyl-tRNA reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9007926", "l": "ATRX binds DAXX (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852552", "l": "MST1R autophosphorylates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39112", "l": "4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NADP(+) => 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34903", "l": "4 glutathione + 2 H(+) + selenite = glutathione disulfide + 3 H2O + selenodiglutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769383", "l": "CBY1 binds beta-catenin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57195", "l": "H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] <=> glycolate + H(+) + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17869", "l": "5,6,7,8-tetrahydropteridine + NAD(+) = 6,7-dihydropteridine + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606583", "l": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64049", "l": "(13Z)-docosenoyl-CoA + sphinganine => CoA + H(+) + N-(13Z-docosenoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64264", "l": "atrochrysone carboxylate + H(+) = atrochrysone + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-389756", "l": "AKT interacts and phosphorylates Cot (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73932", "l": "Resynthesis of excised residue by POLB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74723", "l": "Endosome acidification (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14652", "l": "demethyllactenocin + dTDP-beta-L-mycarose <=> demethylmacrocin + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50410", "l": "2-heptyl-4(1H)-quinolone + H2O => 1-(2-aminophenyl)decane-1,3-dione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682769", "l": "LGI2 binds ADAM22,23 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13877", "l": "a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43918", "l": "(25R)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114683", "l": "Phosphorylation of Platelet Sec-1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031386", "l": "protein tag"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44695", "l": "a fatty acyl-CoA + hexadecasphinganine <=> CoA + H(+) + N-acylhexadecasphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46774", "l": "a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 1-octadecanoyl 2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047934", "l": "glucose 1-dehydrogenase (NAD+) activity"}, {"i": "MetaCyc:GLUCOSE-1-DEHYDROGENASE-NAD+-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668335", "l": "CHMP7 binds LEMD2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59915", "l": "(E)-4-hydroxynon-2-enal + H2O + NADP(+) <=> (E)-4-hydroxynon-2-enoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646354", "l": "PolyUb-Misfolded Proteins:HDAC6 dissociate from complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18929", "l": "AH2 + O2 + thiophene-2-carbonyl-CoA = 5-hydroxythiophene-2-carbonyl-CoA + A + H(+) + H2O"}, {"i": "EC:1.14.99.35", "l": "\"Thiophene-2-carbonyl-CoA monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20853", "l": "ATP + H(+)(in) + H2O => ADP + 2 H(+)(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50530", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450422", "l": "KSRP recruits RNA degradation activities (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13616", "l": "beta-D-fructose 6-phosphate + diphosphate <=> beta-D-fructose 1,6-bisphosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19811", "l": "CO2 + glyoxylate + 2 NH4(+) => (S)-ureidoglycolate + 2 H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9017507", "l": "RHOJ binds effectors at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16198", "l": "(3S)-3-hydroxybutanoyl-CoA + NADP(+) => acetoacetyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40971", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16024", "l": "oxaloacetate <=> enol-oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57045", "l": "D-apionate + NAD(+) => 3-oxoisoapionate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40122", "l": "H2O + tetradecanoyl-CoA <=> CoA + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31084", "l": "H2O + N-acetyl-D-muramoyl-L-alanine => L-alanine + N-acetyl-D-muramate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863727", "l": "STON2 is neddylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848314", "l": "IL36:IL1RL2 binds IL1RAP-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684096", "l": "CDK2 phosphorylates RBBP8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210881", "l": "Dimerization of Tie2/Ang1 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31401", "l": "all-trans-4,4'-diapo-zeta-carotene + FADH2 => all-trans-4,4'-diapophytofluene + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53642", "l": "(-)-alpha-amorphene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944215", "l": "Association of procollagen type XX (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668395", "l": "CHMP7 binds CC2D1B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54204", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2 = 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37600", "l": "(9Z,12Z)-hexadecadienoyl-CoA + AH2 + O2 => (9Z,12Z,15Z)-hexadecatrienoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50992", "l": "thromboxane B2(out) = thromboxane B2(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682011", "l": "LC3 binds ATG7 dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0099528", "l": "G protein-coupled neurotransmitter receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36624", "l": "3-phenylpyruvate + S-adenosyl-L-methionine => (3S)-2-oxo-3-phenylbutanoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60008", "l": "a tRNA precursor + 2 CTP = a tRNA with a 3' CC end + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19439", "l": "N-(beta-D-glucosyl)nicotinate + UDP => nicotinate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46168", "l": "ATP + CoA + pentanoate = AMP + diphosphate + pentanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2002401", "l": "Association of procollagen type XVIII (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180905", "l": "Association of Vpr with ANT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050237", "l": "pyridoxine 4-oxidase activity"}, {"i": "MetaCyc:PYRIDOXINE-4-OXIDASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36454", "l": "ATP + glycyl-L-glutamate(out) + H2O <=> ADP + glycyl-L-glutamate(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452392", "l": "Transcription of POU5F1 (OCT4) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109639", "l": "Formation of the closed pre-initiation complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047516", "l": "1,3-propanediol dehydrogenase activity"}, {"i": "RHEA:23188", "l": "NAD(+) + propane-1,3-diol = 3-hydroxypropanal + H(+) + NADH"}, {"i": "EC:1.1.1.202", "l": "\"1,3-propanediol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400492", "l": "PCSK1 hydrolyzes proGIP to GIP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40123", "l": "an omega-hydroxy fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-oxo fatty acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23766", "l": "H(+) + O-phospho-L-serine + phosphate => diphosphate + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18330", "l": "(1S,3R,5S)-sabinol + NAD(+) => (1S,5S)-sabinone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52729", "l": "3'-phosphoadenylyl sulfate + a 12-hydroxyjasmonate => a 12-sulfojasmonate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187332", "l": "Cytosolic CMs translocate to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45224", "l": "(3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA = (2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048248", "l": "CXCR3 chemokine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49075", "l": "dibenzothiophene + 2 FMNH2 + 2 O2 <=> dibenzothiophene 5,5-dioxide + 2 FMN + 2 H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25843", "l": "5-deoxy-D-glucuronate <=> 5-dehydro-2-deoxy-D-gluconate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050109", "l": "morphine 6-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667965", "l": "ANKLE2 binds PP2A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26528", "l": "a (2E)-enoyl-CoA + H2O => a (3R)-3-hydroxyacyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-919404", "l": "Phosphorylated STAT5 is released (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336443", "l": "LIN7, CASK and APBA1 bind (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2301205", "l": "SETD8 monomethylates histone H4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39321", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+) => (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0052673", "l": "prenol kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396337", "l": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42040", "l": "ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose = gangliosideFuc-GM1 (d18:1(4E)) + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23513", "l": "alpha,alpha-trehalose + phosphate => beta-D-glucose 1-phosphate + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46615", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol <=> (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57335", "l": "H2O + 3 O2 + 3 propionate 3-nitronate <=> 3 3-oxopropanoate + 3 H(+) + H2O2 + 2 nitrate + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9010872", "l": "SLIT2 binds Dystroglycan (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6813740", "l": "GDE1 hydrolyzes GroPIns (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9628444", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807106", "l": "PTEN undergoes monoubiquitination (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37838", "l": "aklavinone + H(+) + NADPH + O2 <=> epsilon-rhodomycinone + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48939", "l": "2-oxoglutarate + L-prolyl-[Skp1 protein] + O2 <=> CO2 + succinate + trans-4-hydroxy-L-prolyl-[Skp1 protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203774", "l": "Interaction of Csk with PAG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61737", "l": "steviolmonoside + UDP-alpha-D-glucose => rubusoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6802973", "l": "PLK3 phosphorylates CDC25C (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13974", "l": "diphosphate + H(+)(in) + H2O => 2 H(+)(out) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5252001", "l": "ATP1B4 binds SNW1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029468", "l": "Conversion of PA into DAG by PAP-1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9032751", "l": "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730858", "l": "Autophosphorylation of BTK/ITK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45203", "l": "(6S)-5,6,7,8-tetrahydrofolate + [methyl-Co(III) corrinoid Fe-S protein] <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + [Co(I) corrinoid Fe-S protein] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22357", "l": "diphosphate + oxaloacetate => CO2 + phosphate + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16085", "l": "ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51345", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 8,9-epoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050561", "l": "glutamate-tRNA(Gln) ligase activity"}, {"i": "MetaCyc:6.1.1.24-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57882", "l": "3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-threonyl-[protein] + H(+) + UDP => 3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-alpha-D-xylose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047272", "l": "phosphopolyprenol glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199558", "l": "KIR2DL1 interacting with HLA-C group 2 (Cw3) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026757", "l": "GGT hydrolyses MCTR1 to MCTR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15917", "l": "an aldopyranose + NAD(+) = aldono-1,5-lactone + H(+) + NADH"}, {"i": "EC:1.1.1.121", "l": "\"Aldose 1-dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55047", "l": "(3E,5Z)-tetradecadienoyl-CoA + H2O <=> (3E,5Z)-tetradecadienoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12905", "l": "alpha-D-mannose 1-phosphate + GDP + H(+) = GDP-alpha-D-mannose + phosphate"}, {"i": "EC:2.7.7.22", "l": "\"Mannose-1-phosphate guanylyltransferase (GDP)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54616", "l": "2-oxoglutarate + heptadecanoyl-CoA + O2 = 2-hydroxyheptadecanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57294", "l": "a guanosine in RNA + glycolate + H(+) => an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68595", "l": "ORC2 binds ORC3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805507", "l": "APAF1 binds AVEN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35879", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16669", "l": "H2O + NAD(+) + xanthine = H(+) + NADH + urate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65066", "l": "diphosphate + pestalodiol => dimethylallyl diphosphate + siccayne"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44799", "l": "2-demethylmenaquinol-13 + S-adenosyl-L-methionine <=> H(+) + menaquinol-13 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.186", "l": "\"Glycogenin glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106327", "l": "acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40830", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17797", "l": "[(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose = [(1->4)-beta-D-glucosyl](n+1) + GDP + H(+)"}, {"i": "EC:2.4.1.29", "l": "\"Cellulose synthase (GDP-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27872", "l": "(2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H(+) => (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27673", "l": "1D-myo-inositol 1-phosphate + H2O <=> myo-inositol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429730", "l": "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1028820", "l": "Formation of VAF (virus-activated factor) complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62514", "l": "2-hydroxymelatonin + CO2 + succinate => 2-oxoglutarate + melatonin + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-171059", "l": "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16655", "l": "2-dehydro-D-gluconate + H(+) + NADPH => D-gluconate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43191", "l": "S-adenosyl-L-methionine + uridine(2634) in 25S rRNA <=> H(+) + N(3)-methyluridine(2634) in 25S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43823", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0008017", "l": "microtubule binding"}, {"i": "REACT:R-HSA-9614343", "l": "Viral UL47:UL48 Proteins Bind HCMV Tegumented Virion to Host Microtuble and Dynein complexs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0019534", "l": "toxin transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-888589", "l": "Release of GABA at the synapse (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54573", "l": "a uridine in tRNA => a pseudouridine in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28497", "l": "a menaquinone + dimethyl sulfide + H2O <=> a menaquinol + dimethyl sulfoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169719", "l": "Secreted CD14 binds LPS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707690", "l": "BACH1 binds MAFK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534359", "l": "CatSper Channel Mediated Calcium Transport (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63843", "l": "[thioredoxin]-dithiol + tert-butyl hydroperoxide <=> [thioredoxin]-disulfide + H2O + tert-butanol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004787", "l": "thiamine-diphosphatase activity"}, {"i": "RHEA:27998", "l": "H2O + thiamine diphosphate = H(+) + phosphate + thiamine phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693644", "l": "HOXB1 maintains activation of HOXB1 chromatin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21756", "l": "deacetylisoipecoside + H2O = dopamine + secologanin"}, {"i": "EC:4.3.3.3", "l": "\"Deacetylisoipecoside synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61744", "l": "steviolbioside + UDP-alpha-D-glucose = stevioside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43254", "l": "1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate => 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625029", "l": "SLC1A1 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603445", "l": "Activated NTRK3 stimulates PI3K activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51035", "l": "7-chloroindole-3-pyruvate imine dimer <=> dichlorochromopyrrolate + H(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23447", "l": "(S)-lactate + NAD(+) <=> H(+) + NADH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044668", "l": "sodium:malonate symporter activity"}, {"i": "RHEA:33135", "l": "malonate(in) + Na(+)(in) = malonate(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18196", "l": "H2O + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] <=> (S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218906", "l": "RIPK3 phosphorylates MLKL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14976", "l": "L-aspartate <=> D-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168046", "l": "Collagen type XII degradation by MMP12 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60646", "l": "3alpha-sulfooxy-5alpha-androstan-17-one + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3alpha-hydroxy-5alpha-androstan-17-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675198", "l": "Activated MAPKs phosphorylate BRAF (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30901", "l": "beta-D-gentiobiosyl beta-D-glucosyl crocetin + H(+) + UDP => bis(beta-D-glucosyl) crocetin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102896", "l": "colnelenate synthase activity"}, {"i": "RHEA:28174", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate = colneleate + H2O"}, {"i": "RHEA:28178", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate = colnelenate + H2O"}, {"i": "MetaCyc:RXN-8498"}, {"i": "EC:4.2.1.121", "l": "\"Colneleate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18791", "l": "D-galactosamine 6-phosphate => D-glucosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948027", "l": "RNASEs bind bacterial phospholipids (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425923", "l": "IRE1alpha hydrolyzes Xbp1 mRNA and Xbp1 mRNA is spliced (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57607", "l": "2 [Fe(II)-cytochrome b5] + a 1-tetracosanoyl-2-acyl-phosphoglycerolipid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a 1-[(15Z)-tetracos-15-enoyl]-2-acyl-phosphoglycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672957", "l": "PP2A dephosphorylates KSR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59592", "l": "ATP + beta-alanine + L-arginine = ADP + beta-alanyl-L-arginine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29855", "l": "H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine = D-alanine + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40858", "l": "FAD + H(+) + undecanoyl-CoA <=> FADH2 + trans-2-undecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39715", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + AH2 + O2 = (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36866", "l": "(9Z)-octadecenoyl-CoA + AH2 + O2 <=> (9Z,12Z)-octadecadienoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202437", "l": "Phosphorylation of CARMA1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034928", "l": "1-hydroxypyrene 6,7-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3858475", "l": "ppDVL recruits RAC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9692809", "l": "CDC42 binds effectors at the ER membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876484", "l": "NPC2 transfers CHOL to NPC1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36037", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH => 2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23066", "l": "an aldehyde + FMN + 2 H(+) + H2O + sulfite => an alkanesulfonate + FMNH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24746", "l": "L-methionine = 2-aminobut-2-enoate + methanethiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388814", "l": "Grb2 binds CD28 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046175", "l": "Further sulfation on galactose residues produces KSPG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43346", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate => [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706328", "l": "Active FLT3 binds to SOCS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167468", "l": "Abortive HIV-1 Initiation After Second Transition (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062070", "l": "SAGA complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215406", "l": "PRMT5 binds WDR77 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953356", "l": "Expression of EXTL2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8863463", "l": "STON2 binds SYT proteins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70573", "l": "argininosuccinate <=> fumarate + arginine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210426", "l": "Glutamate synaptic vesicle docking and priming (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44662", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine + H(+) => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4837364", "l": "Secretion of SOD3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10206", "l": "formaldehyde + methylamine + reduced [electron-transfer flavoprotein] => dimethylamine + H(+) + H2O + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60756", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-cinerolone = cinerin I + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.n3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201611", "l": "Caspase-mediated cleavage of Rock-1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23762", "l": "reduced coenzyme F420-(gamma-Glu)(n) => H(+) + H2 + oxidized coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29581", "l": "Fe(2+)(out) + H(+)(out) => Fe(2+)(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0010858", "l": "calcium-dependent protein kinase regulator activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033419", "l": "CUA codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432381", "l": "PDP1 replaces VRI as binder to Clk and cry genes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392195", "l": "Gi activation by P2Y purinoceptor 12 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52922", "l": "16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28452", "l": "N(6)-(D-psicosyl)-L-lysine(out) => N(6)-(D-psicosyl)-L-lysine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109702", "l": "PDPK1 phosphorylates AKT2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018756", "l": "RHOH binds GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20388", "l": "(2R,3R)-dihydroquercetin + H(+) + NADH + O2 <=> (2R,3R)-2,3-dihydrogossypetin + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0016538", "l": "cyclin-dependent protein serine/threonine kinase regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15887", "l": "(S)-lactaldehyde + H(+) + NADPH => NADP(+) + propane-1,2-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66349", "l": "3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + A => (2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18873", "l": "3-chloro-D-alanine + H2O = chloride + H(+) + NH4(+) + pyruvate"}, {"i": "EC:4.5.1.2", "l": "\"3-chloro-D-alanine dehydrochlorinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41768", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E)) = CMP + ganglioside GT1a (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035488", "l": "cytosine/thymine mispair binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023592", "l": "MECP2 binds HTT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54727", "l": "N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33225", "l": "CO2 + NADH + propanoyl-CoA => 2-oxobutanoate + CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395340", "l": "Formation of hydroxyallysine by LOX (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61057", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + lochnericine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797961", "l": "CHDH oxidises Cho to BETALD (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32138", "l": "2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + H(+) + propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.50", "l": "\"3-alpha-hydroxysteroid 3-dehydrogenase (Si-specific)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168870", "l": "Neuraminidase enzymatic release from sialic acid (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158849", "l": "Phenol can form a sulfate conjugate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28810", "l": "glutathione + H2O <=> L-cysteinylglycine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6790038", "l": "Expression of HSP90B1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17958", "l": "3-oxopropanoate => H2O + propynoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086063", "l": "voltage-gated sodium channel activity involved in SA node cell action potential"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376851", "l": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37284", "l": "H2O + L-alanyl-L-histidine => L-alanine + L-histidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162188", "l": "MDMQ10H2 is methylated to DMQ10H2 by COQ5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2768999", "l": "NOTCH1 PEST domain mutants bind JAG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61418", "l": "cis-trans-nepetalactol => (S)-8-oxocitronellyl enol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63826", "l": "aspulvinone E + H2O => 2 3-(4-hydroxyphenyl)pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18324", "l": "2-oxoglutarate + L-leucine <=> 4-methyl-2-oxopentanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64167", "l": "2-methyl-L-serine <=> formaldehyde + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38568", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O => a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22747", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56947", "l": "AH2 + D-ribulose 5-phosphate <=> 1-deoxy-D-xylulose 5-phosphate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694421", "l": "PP6 dephosphorylates SEC24 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48689", "l": "H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine => D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48712", "l": "2 Fe(2+) + 2 H(+) + H2O2 = 2 Fe(3+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14372", "l": "2-phosphoglycolate + H2O <=> glycolate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14036", "l": "H2O + sn-glycero-3-phospho-1D-myo-inositol <=> 1D-myo-inositol 1-phosphate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-76031", "l": "2 H2O2 => O2 + 2 H2O (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44941", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + H2O => 1-O-alkyl-3-acyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102757", "l": "NADPH phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097262", "l": "eoxin D4 synthase activity"}, {"i": "REACT:R-HSA-2161945", "l": "EXC4 is converted to EXD4 by GGT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45509", "l": "[C-phycoerythrin beta-subunit]-Cys(84)-phycoerythrobilin => (2R,3E)-phycoerythrobilin + apo-[C-phycoerythrin beta-subunit]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791102", "l": "Expression of C19orf10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173631", "l": "Activation of C1s (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158849", "l": "Phenol can form a sulfate conjugate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799350", "l": "Exocytosis of specific granule membrane proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694428", "l": "LMAN family proteins bind glycosylated cargo (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811479", "l": "ING2 recruits EP300 to TP53 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53006", "l": "2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371582", "l": "HSBP1 binds HSF1 trimer (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187382", "l": "Degradation of ubiquitinated SMAD3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804253", "l": "MDM2 ubiquitinates JMY (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17248", "l": "3-hydroxyanthranilate + O2 <=> 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22017", "l": "[glutaredoxin]-dithiol + arsenate + glutathione + 2 H(+) => arsenite + glutathionyl-S-S-[glutaredoxin] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36453", "l": "ADP + glycyl-L-glutamate(in) + H(+) + phosphate => ATP + glycyl-L-glutamate(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102614", "l": "germacrene A acid 8beta-hydroxylase activity"}, {"i": "MetaCyc:RXN-15460"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612639", "l": "NRG2-activated ERBB4 binds GABA receptors through GABRA1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16974", "l": "2-hydroxypyridine + AH2 + O2 => 2,5-dihydroxypyridine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64564", "l": "8-epi-ilicicolin H = ilicicolin H"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51417", "l": "a (2S,3R)-flavan-3-ol + 2 NADP(+) => an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62226", "l": "(E)-ascladiol + NADP(+) => H(+) + NADPH + neopatulin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102154", "l": "8C-naringenin dibenzoylmethane tautomer glucosyltransferase activity"}, {"i": "MetaCyc:RXN-11685"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8955844", "l": "RBKS phosphorylates ribose to R5P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56231", "l": "(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphocholine <=> (9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863463", "l": "STON2 binds SYT proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19364", "l": "(2E)-geranyl diphosphate + isopentenyl diphosphate <=> (2E,6E)-farnesyl diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16782", "l": "a fatty acyl-CoA + H2O => a fatty acid + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416516", "l": "GRK2 sequesters activated Gq (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36014", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16568", "l": "2-oxoglutarate + L-histidine <=> 3-(imidazol-5-yl)pyruvate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33622", "l": "ATP + CoA + tetradecanoate <=> AMP + diphosphate + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35605", "l": "D-fructose + phosphate => beta-D-fructose 1-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045437", "l": "uridine nucleosidase activity"}, {"i": "RHEA:15577", "l": "H2O + uridine = D-ribose + uracil"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33129", "l": "beta-D-glucose 6-phosphate + salicyl alcohol => H2O + salicin-6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15213", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA"}, {"i": "EC:2.3.1.61", "l": "\"Dihydrolipoyllysine-residue succinyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41090", "l": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36421", "l": "2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49258", "l": "2-amino-2-deoxy-D-gluconate 6-phosphate(in) + L-histidyl-[protein] => 2-amino-2-deoxy-D-gluconate(out) + N(pros)-phospho-L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102843", "l": "1-18:2-2-16:0-monogalactosyldiacylglycerol desaturase activity (SN2-16:1 forming)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37636", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391934", "l": "DP2 receptor can bind PGD2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159001", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22975", "l": "butanal + CoA + NADP(+) <=> butanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373748", "l": "SEMA4D interacts with CD72 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50531", "l": "acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45288", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2 = 2-glyceryl-prostaglandin G2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32766", "l": "(3R)-3-methyl-D-ornithine + L-lysine <=> (3R)-3-methyl-D-ornithyl-N(6)-L-lysine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17802", "l": "acetyl-CoA + L-phenylalanine => CoA + H(+) + N-acetyl-L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59503", "l": "5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24058", "l": "myo-inositol + phosphate => a myo-inositol phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32687", "l": "(2E)-geranyl diphosphate = diphosphate + tricyclene"}, {"i": "EC:4.2.3.105", "l": "\"Tricyclene synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0016896", "l": "exoribonuclease activity, producing 5'-phosphomonoesters"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12094", "l": "(R)-acetoin => (S)-acetoin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16316", "l": "5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O <=> 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174444", "l": "Formation of C-strand Okazaki fragments (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55477", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + N-acyleicosasphinganine + O2 => 2 [Fe(III)-cytochrome b5] + H2O + N-acyl-4-hydroxyeicosasphinganine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008996", "l": "ribonuclease G activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391939", "l": "TP receptor can bind thromboxane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57010", "l": "2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + formaldehyde + H2O + NAD(+) => 5,5'-dehydrodivanillate + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58365", "l": "a medium-chain primary fatty alcohol + NADP(+) => a medium-chain fatty aldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25901", "l": "D-arabino-hex-3-ulose 6-phosphate => beta-D-fructose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24792", "l": "(2E,4Z)-2-hydroxy-6-oxononadienedioate + H2O <=> (2E)-2-hydroxypenta-2,4-dienoate + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66943", "l": "acetyl-CoA + 22 H(+) + 11 malonyl-CoA + 12 NADPH + S-adenosyl-L-methionine <=> 12 CO2 + 12 CoA + 8 H2O + 12 NADP(+) + S-adenosyl-L-homocysteine + soppiline B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37487", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphocholine = 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55979", "l": "glutathione + thiosulfate <=> H(+) + S-sulfanylglutathione + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36113", "l": "O-methyl gibberellin A1 + S-adenosyl-L-homocysteine => gibberellin A1 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31750", "l": "3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + H2O + NADP(+) <=> 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39247", "l": "(3R)-hydroxy-(11Z)-eicosenoyl-CoA = (2E,11Z)-eicosadienoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66910", "l": "9 CO2 + 10 CoA + 7 H2O + 13 NADP(+) + S-adenosyl-L-homocysteine + soppiline A => acetyl-CoA + 20 H(+) + 9 malonyl-CoA + 13 NADPH + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18048", "l": "6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H2O <=> alpha-D-glucose 1-phosphate + alpha-D-mannose derivative + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797553", "l": "Protein 4.1 binds CASK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64425", "l": "H(+)(out) + L-leucyl-L-proline(out) => H(+)(in) + L-leucyl-L-proline(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730843", "l": "Phosphorylation of LAT by p-SYK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36440", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18515", "l": "D-mannose + H2O2 => D-mannitol + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030108", "l": "HLA-A specific activating MHC class I receptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034658", "l": "isopropylmalate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051997", "l": "2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity"}, {"i": "RHEA:26301", "l": "5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) = (S)-allantoin + CO2"}, {"i": "EC:4.1.1.97", "l": "\"2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66091", "l": "L-kynurenine + oxaloacetate <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141437", "l": "Formation of the MCC complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420128", "l": "SRC-1 phosphorylates SHB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48959", "l": "[thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide <=> [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22202", "l": "(E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + trans-aconitate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-984671", "l": "Chromokinesins form dimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201457", "l": "BMP2 binds to the receptor complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249392", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-179421", "l": "Degradation of multiubiquitinated Nek2A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-264622", "l": "Cho is acetylated to AcCho by CHAT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41203", "l": "1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004368", "l": "glycerol-3-phosphate dehydrogenase (quinone) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161612", "l": "PGH2 is reduced to PGF2a by FAM213B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65045", "l": "4-cyanobenzyl alcohol + NAD(+) => 4-cyanobenzaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60607", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine <=> 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + choline"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051435", "l": "BH4 domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14185", "l": "3-phenylpyruvate + H(+) = 2-phenylacetaldehyde + CO2"}, {"i": "EC:4.1.1.43", "l": "\"Phenylpyruvate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20729", "l": "H2O + L-glutamate + O2 => 2-oxoglutarate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42490", "l": "3'-N-debenzoyl-2'-deoxytaxol + CoA => (3R)-3-amino-3-phenylpropanoyl-CoA + baccatin III"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20320", "l": "L-proline + NADP(+) <=> 1-pyrroline-2-carboxylate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53249", "l": "cholesta-5,7-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxycholest-5-en-7-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43970", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-517674", "l": "p-S158,221-HuR binds mRNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43052", "l": "3-(methylsulfanyl)propanoate + ATP + CoA = 3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate"}, {"i": "EC:6.2.1.44", "l": "\"3-(methylthio)propionyl--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65600", "l": "4,5,8-trihydroxycasbene + 2 NAD(+) = 2 H(+) + jolkinol C + 2 NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698924", "l": "B Nucleocapsid Assembly (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932334", "l": "KEAP1:CUL3:RBX1:NFE2L2 dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35580", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-[6-O-(4-O-beta-D-glucosyl-p-coumaroyl)-2-O-(beta-D-xylosyl)-beta-D-glucosyl]-5-O-(6-O-malonyl-beta-D-glucoside) => cyanidin 3-O-[6-O-(4-O-beta-D-glucosyl-p-coumaroyl)-2-O-(2-O-sinapoyl-beta-D-xylosyl)-beta-D-glucosyl]-5-O-(6-O-malonyl-beta-D-glucoside) + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46515", "l": "2 [Fe(II)-cytochrome b5] + an N-(1,2-saturated acyl)sphinganine + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + an N-[(2'R)-hydroxyacyl]sphinganine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.19", "l": "\"Undecaprenyl-diphosphooligosaccharide--protein glycotransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106261", "l": "tRNA uridine(34) acetyltransferase activity"}, {"i": "RHEA:61020", "l": "acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051996", "l": "squalene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654510", "l": "FGFRL1 binds SPRED1/2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43870", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(out) => a 1-acyl-sn-glycero-3-phosphoethanolamine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950575", "l": "IL12A:IL12B translocates from ER lumen to Golgi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18627", "l": "D-galactono-1,5-lactone + H(+) + NADPH => D-galactose + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36568", "l": "GDP-beta-L-colitose + NAD(+) => GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015366", "l": "malate:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848606", "l": "PTK6 phosphorylates PXN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451418", "l": "Pellino ubiquitinates IRAK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64973", "l": "dUDP + H2O => dUMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350604", "l": "Agmatine + H2O <=> putrescine + urea (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202233", "l": "Inactivation of Lck by Csk (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9624798", "l": "LBR binds KPNB1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088305", "l": "FOXM1 stimulates PLK1 transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24341", "l": "(R,R)-butane-2,3-diol + NAD(+) => (R)-acetoin + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30888", "l": "4-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin => 7,8-dihydropteroate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811412", "l": "Active ARF recruits coatomer to the Golgi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9649108", "l": "HTR3A pentamer binds 5HT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45188", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55991", "l": "H2O + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] <=> beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195378", "l": "Homodimerization of VEGF proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27942", "l": "(3R)-3-hydroxy-D-aspartate = NH4(+) + oxaloacetate"}, {"i": "EC:4.3.1.27", "l": "\"Threo-3-hydroxy-D-aspartate ammonia-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64759", "l": "H2O + S-benzyl-L-cysteine <=> benzylthiol + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6794347", "l": "Homer1,2,3 dimerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110011", "l": "Binding of Grb10 to the insulin receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19805", "l": "a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28696", "l": "hydrogencarbonate(in) => hydrogencarbonate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166072", "l": "MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62988", "l": "dodecanamide + H2O = dodecanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641205", "l": "RSPO:LGR binds ZNRF3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372819", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621404", "l": "CYP51A1 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849094", "l": "ARHGAP35 binds RASA1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950766", "l": "IL27RA dimerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5618093", "l": "ATP hydrolysis by HSP90 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419861", "l": "Melanospin is stimulated by light (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49835", "l": "a fatty aldehyde + H2O + NAD(+) <=> a fatty acid + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-139941", "l": "Binding of IP3 to IP3 receptor (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54833", "l": "a jasmonyl-L-amino acid + O2 + reduced [NADPH--hemoprotein reductase] => a 12-hydroxyjasmonyl-L-alpha-amino acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905394", "l": "retromer complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429683", "l": "CERT:ceramide [ER] => ceramide [Golgi] + CERT [ER] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374251", "l": "DARC  is a non-specific receptor for many chemokines (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-182990", "l": "Sprouty sequesters CBL away from active EGFR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57194", "l": "glycolate + H(+) + L-lysyl-[protein] => H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30829", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61973", "l": "1-O-(13-methyltetradecyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 1-O-(1Z-13-methyltetradecenyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45617", "l": "H2O + N-hexanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexanoyl ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34383", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + UDP-alpha-D-galactofuranose = beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36544", "l": "H2O + mycothiol S-conjugate => 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605063", "l": "Expression of FASN regulated by NR1H2 or NR1H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-167415", "l": "G-protein alpha subunit is inactivated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29834", "l": "Ni(2+)(in) <=> Ni(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57794", "l": "4-methyl-6-nitrocatechol + NAD(+) + nitrite => 3,4-dinitrotoluene + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31140", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) => 3-hydroxy-3-methyl-2-oxobutanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167130", "l": "Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72143", "l": "Lariat Formation and 5'-Splice Site Cleavage (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080043", "l": "quercetin 3-O-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990965", "l": "cytosylglucuronate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2465940", "l": "atRAL is reduced to atROL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28921", "l": "4-aminobutanoate(out) + L-glutamate(in) => 4-aminobutanoate(in) + L-glutamate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13460", "l": "3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N(6)-lipoyl-L-lysine + H(+) <=> [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13475", "l": "H(+) + indole-3-pyruvate + NADH + NH4(+) => H2O + L-tryptophan + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29054", "l": "2 H(+)(in) + H2 + menaquinone-8 <=> 2 H(+)(out) + menaquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937613", "l": "CRHBP binds CRH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19633", "l": "(3S,5S)-3,5-diaminohexanoate + H2O + NAD(+) = (5S)-5-amino-3-oxohexanoate + H(+) + NADH + NH4(+)"}, {"i": "EC:1.4.1.11", "l": "\"L-erythro-3,5-diaminohexanoate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37698", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA <=> 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44654", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a 1-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10681", "l": "L-proline => D-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24352", "l": "ethyl (R)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + H(+) + NADPH"}, {"i": "EC:1.1.1.279", "l": "\"(R)-3-hydroxyacid-ester dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13741", "l": "3-phenylpyruvate + L-tryptophan = indole-3-pyruvate + L-phenylalanine"}, {"i": "EC:2.6.1.28", "l": "\"Tryptophan--phenylpyruvate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46795", "l": "2 [Fe(II)-cytochrome b5] + an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43297", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53671", "l": "(2E,6E)-farnesyl diphosphate <=> (1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-481044", "l": "Surface deployment of platelet alpha granule membrane components (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24697", "l": "acetate + NADP(+) + trans-isoeugenol <=> (E)-coniferyl acetate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42982", "l": "2-aminoprop-2-enoate + phenol => L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052665", "l": "tRNA (uracil-2'-O-)-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40098", "l": "26-oxohexacosanoate + H2O + NAD(+) <=> 2 H(+) + hexacosanedioate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851298", "l": "GPR143 binds L-Dopa (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29016", "l": "phosphate(out) + sn-glycerol 3-phosphate(in) => phosphate(in) + sn-glycerol 3-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801101", "l": "RABGGTA binds RABGGTB (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68849", "l": "Mcm2-7 associates with the Cdt1:CDC6:ORC:origin complex, forming the pre-replicative complex (preRC) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58706", "l": "rifampicin ortho-naphthoquinone carboxamide => rifampicin hemiaminal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199131", "l": "PVR binds CD226 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58513", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390598", "l": "Myosin Binds ATP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004577", "l": "N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"}, {"i": "RHEA:23380", "l": "N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N,N'-diacetylchitobiosyl diphosphodolichol + UDP"}, {"i": "EC:2.4.1.141", "l": "\"N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32350", "l": "2 S-adenosyl-L-methionine + tricetin <=> 3',5'-di-O-methyltricetin + 2 H(+) + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1470009", "l": "Phosphorylation of STATs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48453", "l": "ganglioside GA2 (d18:1(4E)) + H2O => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788346", "l": "Expression of IL13-upregulated plasma membrane proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47140", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851933", "l": "MET phosphorylates GAB1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0016636", "l": "oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor"}, {"i": "EC:1.3.7.-", "l": "\"With an iron-sulfur protein as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389762", "l": "Phosphorylation of PD-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390425", "l": "FAR1 reduces PalmCoA to HXOL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006588", "l": "MECP2 binds the PTPN4 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48373", "l": "1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O => a fatty acid + acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32249", "l": "(6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADPH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35228", "l": "H(+)(out) + rifampicin(in) => H(+)(in) + rifampicin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430096", "l": "GP1b-IX-V binds filamin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862771", "l": "PLA2G2A binds bacterial phospholipids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36512", "l": "(9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA => (11Z)-3-oxoicosenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109822", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37379", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13827", "l": "GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH => GDP-alpha-D-rhamnose + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51275", "l": "(9Z)-octadecenoyl-CoA + glycine <=> CoA + H(+) + N-(9Z-octadecenoyl)glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614460", "l": "Dimerization of procollagen type VI (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35402", "l": "1-O-(trans-4-coumaroyl)-beta-D-glucose + cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) betaine <=> beta-D-glucose + cyanidin 3-O-[6-O-(6-O-4-hydroxycinnamoyl-beta-D-glucosyl)-2-O-beta-D-xylosyl-beta-D-galactoside] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626227", "l": "CP110 and CEP97 dissociate from the centriole (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20832", "l": "ATP + guanine(out) + H2O = ADP + guanine(in) + H(+) + phosphate"}, {"i": "EC:7.6.2.6", "l": "\"ABC-type guanine transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37710", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448678", "l": "CTSG cleaves CASP1(1-404) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38842", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035758", "l": "chemokine (C-C motif) ligand 21 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66846", "l": "asperterpenoid C + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => asperterpenoid A + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35126", "l": "H(+)(out) + L-alanyl-D-glutamate(out) <=> H(+)(in) + L-alanyl-D-glutamate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350769", "l": "trans-Golgi Network Coat Activation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43896", "l": "3beta-hydroxy-5alpha-androstan-17-one + O2 + reduced [NADPH--hemoprotein reductase] = 3beta,7alpha-dihydroxy-5alpha-androstan-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26244", "l": "geranylgeranyl diphosphate <=> diphosphate + elisabethatriene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83650", "l": "FasL:Fas binds FADD (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55157", "l": "a quinone + glutathione + H(+) + hydrogen sulfide => a quinol + S-sulfanylglutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15641", "l": "H(+) + oxaloacetate = CO2 + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800793", "l": "PIDD1 translocates to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623643", "l": "RDH13 reduces atRAL to atROL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5607721", "l": "Activation of NIK (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21881", "l": "2 H(+) + O2 + oxalate => 2 CO2 + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901584", "l": "tetrapeptide transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33397", "l": "GMP + N(alpha)-acetyl-L-lysine methyl ester => H2O + N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111956", "l": "Calmodulin activates Cam-PDE 1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24543", "l": "A + D-glucose <=> AH2 + D-glucono-1,5-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1299359", "l": "Activation of TALK (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37857", "l": "1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14893", "l": "D-ornithine = (2R,4S)-2,4-diaminopentanoate"}, {"i": "EC:5.4.3.5", "l": "\"D-ornithine 4,5-aminomutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50773", "l": "H2O + nitroethane + O2 => acetaldehyde + H(+) + H2O2 + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53273", "l": "5-dehydro-L-gluconate => keto-D-tagaturonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029453", "l": "Phosphorylation of VAV (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36458", "l": "ATP + H2O + L-alanylglycine(out) <=> ADP + H(+) + L-alanylglycine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35167", "l": "minocycline(in) = minocycline(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22819", "l": "D-xylose <=> D-xylulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102541", "l": "D-galactose 6-phosphate 1-epimerase activity"}, {"i": "MetaCyc:RXN-14816"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39395", "l": "3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1454916", "l": "The ABCC family mediates organic anion transport (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-426032", "l": "DAG is metabolized by DAGL to 2-AG (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801762", "l": "REG3A oligomerize to form a pore complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799332", "l": "ATR phosphorylates TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665701", "l": "Phosphorylated ERBB2 TMD/JMD heterodimers bind SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34253", "l": "1-deoxy-3-dehydrosphinganine + H(+) + NADPH => 1-deoxysphinganine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31357", "l": "formaldehyde + H2O + methanethiol + NAD(+) => dimethyl sulfide + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047255", "l": "galactogen 6-beta-galactosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.-", "l": "\"Intramolecular lyases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59276", "l": "L-glutamine = D-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0031877", "l": "somatostatin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211910", "l": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5228992", "l": "ROCK1,ROCK2 are activated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-76052", "l": "Binding of TFIIIA To type 1 Promoter (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65423", "l": "GMP(in) + NAD(+)(out) <=> GMP(out) + NAD(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49435", "l": "cholate + lithocholoyl-CoA <=> choloyl-CoA + lithocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798374", "l": "DYRK2 phosphorylates TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30194", "l": "15-cis-phytoene + plastoquinone-9 <=> 15,9'-di-cis-phytofluene + plastoquinol-9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693356", "l": "CEMIP hydrolyses HA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19584", "l": "N(6)-dimethylallyladenine + S-adenosyl-L-methionine <=> discadenine + H(+) + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977605", "l": "Factor H displaces Bb (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56343", "l": "ent-isokauren-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-isokaurene-2beta,3beta-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64440", "l": "glycylglycyl-L-proline(out) + H(+)(out) = glycylglycyl-L-proline(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036012", "l": "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (c branch) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803917", "l": "TP53 stimulates RGCC expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16207", "l": "N(6)-(D-fructosyl)-L-lysyl-[protein] + phosphate => H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31193", "l": "(2E)-decenoyl-CoA + H2O => (3S)-hydroxydecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.91", "l": "\"Cellulose 1,4-beta-cellobiosidase (non-reducing end)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429992", "l": "PARN deadenylates mRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004795", "l": "threonine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17449", "l": "(2E)-geranyl diphosphate + flaviolin = 3-linalylflaviolin + diphosphate"}, {"i": "EC:2.5.1.123", "l": "\"Flaviolin linalyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54959", "l": "ATP + CoA + OPC-6 <=> AMP + diphosphate + OPC-6-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65970", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ADP + H(+) + phosphate => 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37276", "l": "H2O + L-alanyl-L-glutamine => L-alanine + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112385", "l": "Addition of nucleotides leads to transcript elongation (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23314", "l": "1(F)-beta-D-fructosylsucrose + D-glucose => 2 sucrose"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015324", "l": "peptide-acetyl-CoA secondary active transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58081", "l": "1-docosanoylglycerol + H2O => docosanoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-997237", "l": "SH2B proteins bind JAK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106142", "l": "rRNA (adenine-N1-)-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005332", "l": "gamma-aminobutyric acid:sodium symporter activity"}, {"i": "REACT:R-HSA-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203712", "l": "eNOS associates with Caveolin-1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57670", "l": "(+)-nootkatone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => alpha-nootkatol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693347", "l": "CRYM reduces P2C to PPCA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189062", "l": "lactose + H2O => D-glucose + D-galactose (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5082391", "l": "Trimerization of HSF1 in the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36628", "l": "2-hydroxytetracosanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxytetracosanoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874078", "l": "PTK2 autophosphorylates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "53.372708653416339", "identifiers": [{"i": "GO:0015075", "l": "ion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604308", "l": "NICD4 traffics to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62633", "l": "a hydroperoxide + 2 glutathione => an alcohol + glutathione disulfide + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005290", "l": "L-histidine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009309", "l": "RUNX2 binds STUB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65628", "l": "sphinga-(4E,8Z)-dienine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoylsphinga-(4E,8Z)-dienine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047696", "l": "beta-adrenergic receptor kinase activity"}, {"i": "REACT:R-HSA-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202144", "l": "Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42399", "l": "cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine <=> 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168376", "l": "STIM1 oligomerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20471", "l": "D-ribose 5-phosphate + hypoxanthine => H2O + IMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163672", "l": "Phosphorylation of ChREBP at Thr(666) by PKA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48747", "l": "(-)-yatein + 2-oxoglutarate + O2 <=> (-)-deoxypodophyllotoxin + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24388", "l": "phosphate + uridine = alpha-D-ribose 1-phosphate + uracil"}, {"i": "EC:2.4.2.3", "l": "\"Uridine phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9656244", "l": "DRD2 binds DA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706298", "l": "Active FLT3 binds to CSK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201630", "l": "Caspase-mediated cleavage of Acinus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005175", "l": "CD27 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13446", "l": "(R)-pantetheine + H2O => (R)-pantothenate + cysteamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61112", "l": "(2R,3R)-dihydrokaempferol + O2 + reduced [NADPH--hemoprotein reductase] = (2R,3R)-dihydroquercetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086200", "l": "Dentin matrix protein 1 binds integrin alphaVbeta3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "73.344328060803463", "identifiers": [{"i": "GO:0019205", "l": "nucleobase-containing compound kinase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:1990888", "l": "2-polyprenyl-6-hydroxyphenol O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63577", "l": "ecdysone 22-phosphate + H2O => ecdysone + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20871", "l": "alpha,alpha-trehalose + H2O <=> 2 D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23939", "l": "D-gluconate + NADP(+) <=> 5-dehydro-D-gluconate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25530", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59583", "l": "hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester <=> CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6790038", "l": "Expression of HSP90B1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40189", "l": "(3R)-hydroxyoctanoyl-CoA => (2E)-octenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44488", "l": "3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45028", "l": "(2S)-methylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein]"}, {"i": "EC:1.3.8.12", "l": "\"(2S)-methylsuccinyl-CoA dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61880", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-12-hydroperoxy-20-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865454", "l": "CBFB binds RUNX3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850534", "l": "PDCL promotes G-protein beta 5 folding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15192", "l": "2 [Fe(III)cytochrome c553] + formate <=> 2 [Fe(II)cytochrome c553] + CO2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9713837", "l": "Psoralens in combination with UV generate DNA interstrand crosslinks (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13200", "l": "H(+) + sulfite + UDP-alpha-D-glucose <=> H2O + UDP-alpha-D-6-sulfoquinovose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19782", "l": "2-oxoglutarate + 3,5-diiodo-L-tyrosine => 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209828", "l": "Tryptophan is hydroxylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45109", "l": "(+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase] => 13-hydroxy-alpha-tocopherol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6783670", "l": "CRLF1 binds CLCF1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18020", "l": "H(+) + indole-3-pyruvate <=> CO2 + indole-3-acetaldehyde"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033407", "l": "UCA codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0071814", "l": "protein-lipid complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13793", "l": "2-methyleneglutarate = 2-methylene-3-methylsuccinate"}, {"i": "EC:5.4.99.4", "l": "\"2-methyleneglutarate mutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45682", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphate(out) => N-(hexadecanoyl)-sphing-4-enine-1-phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21795", "l": "NADP(+) + propan-2-ol <=> acetone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.21", "l": "\"Glycerol-1-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60934", "l": "17-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36489", "l": "H(+) + N(1)-aminopropylagmatine + S-methyl-5'-thioadenosine => agmatine + S-adenosyl 3-(methylsulfanyl)propylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57364", "l": "H2O + NADH = (6S)-NADHX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36499", "l": "2-dehydro-3-deoxy-L-rhamnonate + NAD(+) = 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH"}, {"i": "EC:1.1.1.401", "l": "\"2-dehydro-3-deoxy-L-rhamnonate dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-452097", "l": "Recruited STAT5 is phosphorylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.-", "l": "\"Acting on ATP; involved in cellular and subcellular movement\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12459", "l": "CTP + D-ribitol 5-phosphate + H(+) <=> CDP-L-ribitol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9690461", "l": "FKBP1A binds tacrolimus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034075", "l": "arabidiol synthase activity"}, {"i": "MetaCyc:RXN-9684"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951966", "l": "EP300 acetylates RUNX3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63772", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372843", "l": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50502", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[protein] => acetyl-CoA + N-terminal L-alanyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864577", "l": "TFAP2C translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33795", "l": "H2O + sucrose = alpha-D-glucose + beta-D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.4", "l": "\"Glutamate dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39184", "l": "3-oxodocosanoyl-CoA + H(+) + NADPH => (3R)-hydroxydocosanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41116", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020274", "l": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37268", "l": "H2O + L-alanyl-L-aspartate => L-alanine + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12765", "l": "CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate = acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693250", "l": "RHOD binds effectors at the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66082", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminopentanoate => 2-oxopentanoate + L-kynurenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26277", "l": "Co-precorrin-4 + S-adenosyl-L-methionine = Co-precorrin-5A + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.271", "l": "\"Cobalt-precorrin-4 methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40631", "l": "H2O + trioctadecanoylglycerol = 2,3-dioctadecanoyl-sn-glycerol + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28794", "l": "5,6-dihydrothymine + NAD(+) <=> H(+) + NADH + thymine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66874", "l": "9-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71445", "l": "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9646468", "l": "mTORC1 binds RHEB:GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186780", "l": "PI3-kinase binds to the active receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62965", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP-beta-L-fucose => alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30152", "l": "FADH2 + NADP(+) => FAD + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047219", "l": "monoterpenol beta-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37679", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40587", "l": "H2O + octanedioyl-CoA = CoA + H(+) + octanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47067", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51295", "l": "a quinone + H2O + L-methionyl-[protein] <=> a quinol + L-methionyl-(S)-S-oxide-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106032", "l": "snRNA pseudouridine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64785", "l": "S-ethyl-L-cysteine => 2-aminoprop-2-enoate + ethanethiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39555", "l": "3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12830", "l": "(2S,3S)-3-methyl-L-aspartate => mesaconate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29754", "l": "acetoacetate(in) <=> acetoacetate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425861", "l": "Activation of Protein Kinase C novel isoforms (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43983", "l": "H(+) + hexadecanoate + NADPH + O2 <=> 15-hydroxyhexadecanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26538", "l": "hydrogencarbonate + NH4(+) + phosphate = carbamoyl phosphate + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56044", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3)"}, {"i": "EC:3.2.1.210", "l": "\"Endoplasmic reticulum Man(8)GlcNAc(2) 1,2-alpha-mannosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2230983", "l": "LRP1:Hemopexin:heme is endocytosed (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.34", "l": "\"Lipoprotein lipase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3095901", "l": "ABCC1 transports cytosolic Cbl to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430158", "l": "p-SLP-76 binds VAV (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61957", "l": "1-O-octadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56621", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + H2O => 2,4,5-trichlorocyclohexa-2,5-dien-1-ol + chloride + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690152", "l": "USP5 cleaves polyubiquitin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32464", "l": "glycine + 2 S-adenosyl-L-methionine => 2 H(+) + N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28122", "l": "ATP + di-trans,octa-cis-undecaprenol = ADP + di-trans,octa-cis-undecaprenyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707659", "l": "Hemes:LY96 activates TLR4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20604", "l": "formaldehyde + mycothiol + NAD(+) <=> H(+) + NADH + S-formylmycothiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5688294", "l": "SIRT5 deacetylates Cytochrome C (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690023", "l": "NUBPL binds 4Fe-4S (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64726", "l": "(7S,14S)-dihydroperoxy-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoate => (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55454", "l": "daturadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50841", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602885", "l": "Defective CYP7B1 does not 7-hydroxylate 25OH-CHOL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.152"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.30"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27805", "l": "(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate <=> all-trans-decaprenyl diphosphate + 7 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53857", "l": "NADP(+) + ursocholate => 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.73", "l": "\"U-plasminogen activator\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19794", "l": "H(+) + H2O + oxidized [electron-transfer flavoprotein] + sarcosine => formaldehyde + glycine + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9659820", "l": "RB1 translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44132", "l": "2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = 2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine"}, {"i": "EC:2.5.1.128", "l": "\"N(4)-bis(aminopropyl)spermidine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54897", "l": "(10Z,15Z)-12-oxophytodienoate + ATP + CoA => (10Z,15Z)-12-oxophytodienoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62520", "l": "a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31414", "l": "a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624954", "l": "INPP5E translocates to the primary cilium (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9017817", "l": "Gamma-secretase cleaves YBX1:NOTCH3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32788", "l": "ATP + H2O + L-ectoine(out) => ADP + H(+) + L-ectoine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204779", "l": "Interaction of Tie2 with Ang1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48405", "l": "apo-[EntB isochorismatase/aryl-carrier protein] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[EntB isochorismatase/aryl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51486", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004071", "l": "aspartate-ammonia ligase activity"}, {"i": "RHEA:11372", "l": "ATP + L-aspartate + NH4(+) = AMP + diphosphate + H(+) + L-asparagine"}, {"i": "EC:6.3.1.1", "l": "\"Aspartate--ammonia ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028815", "l": "p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3229181", "l": "CALM1:Ca2+ binds CNG channel (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45428", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine = H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029690", "l": "Caspase-6 translocates to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34137", "l": "Delta(9)-tetrahydrocannabinolate + H2O2 => cannabigerolate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1168376", "l": "STIM1 oligomerizes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26069", "l": "3-(hydrohydroxyphosphoryl)pyruvate + acetyl-CoA + H2O => CoA + H(+) + phosphinomethylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52091", "l": "5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA <=> 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685242", "l": "CHEK1 phosphorylates BRCA2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57968", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 8-epi-inunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.170", "l": "\"8-epi-inunolide synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191299", "l": "Squalene is oxidized to its epoxide (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708327", "l": "ANG cleaves tRNA to yield tRNA halves (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52556", "l": "3-dehydro-D-erythronate + ATP = 3-dehydro-4-O-phospho-D-erythronate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61969", "l": "2 [Fe(II)-cytochrome b5] + a 1-O-(9Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a 1-O-(1Z,9Z-octadecadienyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55075", "l": "2-oxobutanoate + H(+) <=> CO2 + propanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39012", "l": "a triacyl-sn-glycerol(in) => a triacyl-sn-glycerol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.30"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24448", "l": "enterobactin + UDP-alpha-D-glucose = monoglucosyl-enterobactin + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102241", "l": "soyasaponin III rhamnosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426223", "l": "Cation influx mediated by TRPC3/6/7 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52051", "l": "9-(9Z-octadecenoyloxy)-octadecanoate + H2O <=> (9Z)-octadecenoate + 9-hydroxy-octadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23201", "l": "H2O + N(6)-methyl-L-lysine + O2 => formaldehyde + H2O2 + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15875", "l": "[(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+) => [(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.102"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3769397", "l": "SOST binds LRP5/6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5334794", "l": "FABPs bind LCFAs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55883", "l": "apo-[aequorin]--coelenterazine + O2 <=> [aequorin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36352", "l": "AH2 + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-methionine => 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + A + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055053", "l": "mannose:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16777", "l": "ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate"}, {"i": "EC:7.2.2.6", "l": "\"P-type K(+) transporter\""}]}
{"type": "biolink:MolecularActivity", "ic": "56.05892131353351", "identifiers": [{"i": "GO:0140640", "l": "catalytic activity, acting on a nucleic acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29380", "l": "dGMP + H2O => 2'-deoxyguanosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050235", "l": "pyridoxal 4-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21969", "l": "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate => 3-dehydroquinate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24387", "l": "ATP + deamido-NAD(+) + H2O + L-glutamine <=> AMP + diphosphate + H(+) + L-glutamate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866858", "l": "CFTR F508del is degraded by the 26S proteasome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33053", "l": "betaine aldehyde + H(+) + NADH => choline + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685838", "l": "CX3 complex binds D-loop structures (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39055", "l": "22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27687", "l": "ATP + GDP => ADP + GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350058", "l": "Formation of CSL NCOR corepressor complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.44"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58251", "l": "5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O <=> ADP-D-ribose + H(+) + L-glutamyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036381", "l": "pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140340", "l": "cerebroside transfer activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49818", "l": "3 [Fe(II)cytochrome c] + 2 H(+) + NH4(+) + nitric oxide => 3 [Fe(III)cytochrome c] + H2O + hydrazine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4341073", "l": "PIAS3 SUMOylates PGR with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38787", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38766", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49219", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O <=> 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57756", "l": "2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH = C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797090", "l": "CCNK binds CDK12 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445072", "l": "Interaction of PAK1 with Rac1-GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26340", "l": "L-homocysteine + S-methyl-L-methionine <=> H(+) + 2 L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046978", "l": "TAP1 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64371", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 A <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47643", "l": "adenosine(1785)/adenosine(1786) in 18S rRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(6)-dimethyladenosine(1785)/N(6)-dimethyladenosine(1786) in 18S rRNA + 4 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008659", "l": "(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity"}, {"i": "RHEA:41892", "l": "(3R)-hydroxytetradecanoyl-[ACP] = (2E)-tetradecenoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336420", "l": "DT fragment B transports DT fragment A from target cell endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047132", "l": "dihydrobenzophenanthridine oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61663", "l": "(2E)-geraniol + ATP <=> (2E)-geranyl phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15882", "l": "ATP + L-seryl-[Fas-activated protein] => ADP + H(+) + O-phospho-L-seryl-[Fas-activated protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56232", "l": "[(1->4)-alpha-D-galacturonosyl](n) + H2O = [(1->4)-alpha-D-galacturonosyl](n-2) + alpha-D-galacturonosyl-(1->4)-D-galacturonate"}, {"i": "EC:3.2.1.82", "l": "\"Exo-poly-alpha-digalacturonosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2467775", "l": "Autocleavage of ESPL1 (Separase) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57118", "l": "1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196929", "l": "FLAD1 phosphorylates FMN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102893", "l": "betanidin 6-O-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-8480"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42067", "l": "ATP + GTP <=> 2',3'-cGAMP + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11802", "l": "AMP + beta-nicotinamide D-ribonucleotide + 2 H(+) => H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372742", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10105", "l": "2-oxoglutarate + gibberellin A20 + O2 => CO2 + gibberellin A1 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15584", "l": "biochanin A 7-O-beta-D-glucoside + malonyl-CoA <=> biochanin A 7-O-beta-D-glucoside 6''-O-malonate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63633", "l": "a long-chain fatty acyl-AMP + holo-[ACP] => a long-chain fatty acyl-[ACP] + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14571", "l": "H2O + propanal => propane-1,2-diol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031731", "l": "CCR6 chemokine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38925", "l": "a ubiquinol + Na(+)(out) + NAD(+) => a ubiquinone + H(+) + Na(+)(in) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29272", "l": "a menaquinol + H(+) + trimethylamine N-oxide => a menaquinone + H2O + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74986", "l": "Elongation of pre-rRNA transcript (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781840", "l": "ERCC6 binds stalled RNA Pol II (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37278", "l": "H2O + L-alanyl-L-glutamine <=> L-alanine + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15890", "l": "H2O + L-glutamine => L-glutamate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5658435", "l": "RAS GAPs bind RAS:GTP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58757", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + H(+) + NADPH => 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9687638", "l": "MLKL binds IP4, IP5 and IP6  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25642", "l": "(1R,4S)-menthone + NADP(+) => (R)-pulegone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41790", "l": "acetyl-[ACP] + CoA => acetyl-CoA + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047002", "l": "L-arabinitol 2-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57472", "l": "(E)-4-coumarate + UDP-alpha-D-glucose = 1-O-(trans-4-coumaroyl)-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043849", "l": "Ras palmitoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15094", "l": "2-oxoglutarate + L-tyrosine => 3-(4-hydroxyphenyl)pyruvate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202947", "l": "Caspase mediated cleavage of APC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374723", "l": "Nociceptin receptor binds to nociceptin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380782", "l": "STAT binds to the active receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31263", "l": "but-3-ynal + H(+) + pyrroloquinoline quinol = but-3-yn-1-ol + pyrroloquinoline quinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55128", "l": "(3R)-hydroxy-5-methylhexanoyl-[ACP] = (2E)-5-methylhexenoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227753", "l": "Caspase 8 or 10 recruitment to IPS1 complex followed by their dimerization (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19188", "l": "glyoxylate + H2O + propanoyl-CoA <=> 2-hydroxyglutarate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31348", "l": "(+)-abscisic acid D-glucopyranosyl ester + H2O => 2-cis-(+)-abscisate + beta-D-glucose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45831", "l": "(3R)-hydroxyhexanoyl-CoA + NAD(+) <=> 3-oxohexanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357479", "l": "p-AXL binds PI3K (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047970", "l": "guanidinoacetase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447219", "l": "IL17RA and IL17RB bind IL25 dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38030", "l": "(E)-caffeate + hydrocaffeoyl-CoA <=> (E)-caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.99"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22049", "l": "7,8-dihydroneopterin 3'-triphosphate => 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56875", "l": "(S)-N-acetyl-1-phenylethylamine + H2O <=> (S)-1-phenylethylamine + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64611", "l": "L-threonyl-[protein] + UTP <=> diphosphate + uridylyl-L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688834", "l": "ATXN3 binds VCP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65592", "l": "8-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] = 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6805981", "l": "HMGB1 release from cells (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35831", "l": "2-oxoglutarate + kanamycin B + O2 = 2'-dehydrokanamycin A + CO2 + NH4(+) + succinate"}, {"i": "EC:1.14.11.37", "l": "\"Kanamycin B dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-990489", "l": "Kinesin-13 is a dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-741386", "l": "RIP2 induces K63-linked ubiquitination of NEMO (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102113", "l": "hypoxia-inducible factor-asparagine oxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55763", "l": "a fatty acyl-[ACP] + a lyso-ornithine lipid <=> an N(2)-[(3R)-3-(acyloxy)acyl]-L-ornithine lipid + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32893", "l": "alpha-pinene oxide + H2O + NAD(+) => (1S,5S)-alpha-pinene + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669250", "l": "PAK1 phosphorylates FLNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43992", "l": "(2E,6E,10E)-geranylgeraniol + H(+) + NADPH + O2 = 16-hydroxy-(2E,6E,10E)-geranylgeraniol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209944", "l": "25(OH)D binds GC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419049", "l": "ROCK activation by RHO (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173626", "l": "Activation of C1r (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686071", "l": "GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58902", "l": "NH4(+) + urea-1,3-dicarboxylate => 1-carboxybiuret + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11470", "l": "3-methyl-2-oxobutanoate + L-isoleucine => (S)-3-methyl-2-oxopentanoate + L-valine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202168", "l": "Phosphorylation of ZAP-70 by Lck (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047350", "l": "glucuronate-1-phosphate uridylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58745", "l": "H2O + N(7)-methyl-GTP => diphosphate + H(+) + N(7)-methyl-GMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50258", "l": "25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17822", "l": "hydrogen cyanide + L-cysteine => 3-cyano-L-alanine + H(+) + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.67", "l": "\"Zingipain\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64102", "l": "H(+) + S-adenosyl-L-homocysteine + TAN-1612 => 2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34171", "l": "L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O"}, {"i": "EC:4.3.3.7", "l": "\"4-hydroxy-tetrahydrodipicolinate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39243", "l": "(11Z)-3-oxoicosenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z)-eicosenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034918", "l": "3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080104", "l": "5-methylthiopropyl glucosinolate S-oxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6804741", "l": "MDM2 forms homo- or heterodimers (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45555", "l": "H2O + N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-tetradecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60251", "l": "A + H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] <=> AH2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32486", "l": "H(+) + H2O + pheophorbide a <=> CO2 + methanol + pyropheophorbide a"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-912734", "l": "CBL:CRKL binds RAPGEF1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36858", "l": "an N-acetyl-L-cysteine-S-conjugate + H2O <=> acetate + an S-substituted L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20185", "l": "a CMP-N-acyl-beta-neuraminate + H2O = an N-acylneuraminate + CMP + H(+)"}, {"i": "EC:3.1.4.40", "l": "\"CMP-N-acylneuraminate phosphodiesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27385", "l": "H2O + maleamate = maleate + NH4(+)"}, {"i": "EC:3.5.1.107", "l": "\"Maleamate amidohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24451", "l": "enterobactin + UDP-alpha-D-glucose <=> monoglucosyl-enterobactin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63034", "l": "a fatty acid + NH4(+) => a fatty acylamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417908", "l": "P2RY1 binds ADP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45243", "l": "a (3E,5Z)-dienoyl-CoA <=> a (2E,4E)-(5,6-saturated)-dienoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42336", "l": "[thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.8.7.2", "l": "\"Ferredoxin:thioredoxin reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12888", "l": "GDP-alpha-D-mannose + queuosine 5'-phosphate in tRNA(Asp) <=> beta-D-mannosyl-5''-O-queuosine 5'-phosphate in tRNA(Asp) + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16419", "l": "H(+) + L-glutamate + NADH => (S)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12819", "l": "biochanin A + 2 H(+) + NADPH => 2,3-dihydrobiochanin A + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11499", "l": "O-acetyl-L-serine + uracil <=> 3-(uracil-1-yl)-L-alanine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2247513", "l": "STAB1:ligand is endocytosed (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50069", "l": "ATP + glycoursodeoxycholate(in) + H2O => ADP + glycoursodeoxycholate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35938", "l": "2 ATP + L-proline + L-tryptophan <=> 2 AMP + brevianamide F + 2 diphosphate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956365", "l": "ZBED1 (DREF) SUMOylates CHD3 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429699", "l": "CERT [ER] + ceramide [ER] => CERT:ceramide [ER] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606564", "l": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-984606", "l": "Kinesin-5 is a homotetramer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35995", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112514", "l": "JAK activation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41899", "l": "(2E)-tetradecenoyl-[ACP] + H(+) + NADPH <=> NADP(+) + tetradecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48697", "l": "1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O => H(+) + octanoate + octanoyl-3-(beta-D-galactosyl)-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.9.-", "l": "\"With a copper protein as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35999", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27579", "l": "(R)-N-tert-butylpiperazine-2-carboxamide + H2O => (R)-piperazine-2-carboxylate + tert-butylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11967", "l": "5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O <=> 5alpha-cholestane-3beta,5,6beta-triol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83677", "l": "C4 deamination of cytidine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018794", "l": "RHOV binds effectors at the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12729", "l": "lutein = (3R,3'S)-zeaxanthin"}, {"i": "EC:5.3.3.22", "l": "\"Lutein isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.2.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9637651", "l": "esxA translocates from Mtb cytosol to the host's ER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19346", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate => (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43170", "l": "inosine(34) in tRNA + NH4(+) => adenosine(34) in tRNA + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32837", "l": "4-(trimethylamino)butanoate(out) => 4-(trimethylamino)butanoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0140135", "l": "mechanosensitive cation channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5658430", "l": "NF1 is degraded by the proteasome (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17648", "l": "H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] <=> N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10388", "l": "GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51629", "l": "formate + H(+) + UTP => CO2 + dUTP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295632", "l": "PPA2A dephosphorylates SPRY2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61349", "l": "ATP + estrone 3-sulfate(in) + H2O => ADP + estrone 3-sulfate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169847", "l": "Assembly of NA tetramers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007561", "l": "E2F1 binds RAD51 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46649", "l": "17-hydroxy-3-oxochol-4-en-22-oyl-CoA => androst-4-ene-3,17-dione + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16769", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 1-phosphate = (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)"}, {"i": "EC:2.7.1.106", "l": "\"Glucose-1,6-bisphosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9734713", "l": "ORC6 translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18516", "l": "D-mannitol + O2 <=> D-mannose + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21402", "l": "CO2 + NADPH + succinyl-CoA => 2-oxoglutarate + CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38730", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030367", "l": "interleukin-17 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35869", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61985", "l": "H(+) + NADH + ubiquinone-10 => NAD(+) + ubiquinol-10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390663", "l": "ADRA2A,B,C bind ADR,NAd (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730862", "l": "Autophosphorylation of LYN kinase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42287", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-874087", "l": "SGT1 binds HSP90 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36819", "l": "(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11207", "l": "apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin <=> AMP + diphosphate + H(+) + holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25446", "l": "(1E,4E)-germacrene B + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448632", "l": "IL34 dimerizes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30233", "l": "(2E,6E)-farnesal + H2O2 + L-cysteine => H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001085", "l": "arabinogalactan binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62579", "l": "ATP + H2O + L-cystine(out) <=> ADP + H(+) + L-cystine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047194", "l": "indoleacetylglucose-inositol O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31942", "l": "2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + O2 + reduced [NADPH--hemoprotein reductase] <=> DIBOA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54458", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3245898", "l": "TCN1 binds Cbl in the circulation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061815", "l": "deubiquitinase, acting on linear ubiquitin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38633", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625416", "l": "Anterograde IFT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030169", "l": "low-density lipoprotein particle binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16734", "l": "H(+) + orsellinate => CO2 + orcinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46429", "l": "4beta-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-4beta,26-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58568", "l": "15alpha-stemmadenine + acetyl-CoA = CoA + O-acetyl-15alpha-stemmadenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803892", "l": "SFN dimer binds BAX (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035275", "l": "dibutyl phthalate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40044", "l": "ATP + citrate + L-glutamate => ADP + beta-citrylglutamate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190829", "l": "Lysosomal degradation of gap junction plaques (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112434", "l": "Formation of DSIF complex  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13584", "l": "N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033439", "l": "ACA codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952101", "l": "p14-ARF transcription is stimulated by RUNX proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990448", "l": "exon-exon junction complex binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102875", "l": "1-18:2-2-18:2-monogalactosyldiacylglycerol desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449058", "l": "Interleukin-1 family are secreted (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46344", "l": "propanoyl-CoA + tetradecanoyl-CoA = 3-oxo-2-methylhexadecanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25164", "l": "A + butanoyl-CoA = (2E)-butenoyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25048", "l": "(2E)-2-hydroxypenta-2,4-dienoate + fumarate + H(+) => (2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22925", "l": "dCMP + H(+) + H2O => dUMP + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63872", "l": "2-oxoglutarate + L-isoleucine + O2 = 3(1)-hydroxy-L-isoleucine + CO2 + succinate"}, {"i": "EC:1.14.11.74", "l": "\"L-isoleucine 3(1)-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444661", "l": "HCAR2 binds HCAR2 ligands (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865482", "l": "KMT2A (MLL) binds RUNX1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381116", "l": "Phosphorylated IRE1 dimer binds ADP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33109", "l": "diphosphate + gamma-muurolene => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32854", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol <=> a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395412", "l": "Phosphorylation of SYK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41601", "l": "1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5632677", "l": "PTCH is internalized (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010486", "l": "manganese:proton antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250272", "l": "TXNIP binds NLRP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786110", "l": "JAK1 binds IL4R in IL13-bound IL13R type II (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009072", "l": "STAT3 phosphorylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29512", "l": "(2E,6E)-farnesyl diphosphate => (+)-valencene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43540", "l": "ATP + L-seryl-[isocitrate dehydrogenase] = ADP + H(+) + O-phospho-L-seryl-[isocitrate dehydrogenase]"}, {"i": "EC:2.7.11.5", "l": "\"[Isocitrate dehydrogenase (NADP(+))] kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374672", "l": "Cis-heterodimerization of L1 and Axonin-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45144", "l": "3-(methylsulfanyl)acryloyl-CoA + 2 H2O = acetaldehyde + CO2 + CoA + methanethiol"}, {"i": "EC:4.2.1.155", "l": "\"Methylthioacryloyl-CoA hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4411402", "l": "Activation of NLK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47391", "l": "a tetradecanoate ester + H2O <=> an aliphatic alcohol + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40156", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42649", "l": "(2,5-ethylene furandicarboxylate)(n) + 2 H2O => (2,5-ethylene furandicarboxylate)(n-1) + 2,5-dicarboxyfuran + ethylene glycol + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950426", "l": "Expression of lymphocyte cytosolic protein 1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38177", "l": "all-trans-retinyl hexadecanoate + CoA => all-trans-retinol + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047605", "l": "acetolactate decarboxylase activity"}, {"i": "RHEA:21580", "l": "(2S)-2-acetolactate + H(+) = (R)-acetoin + CO2"}, {"i": "EC:4.1.1.5", "l": "\"Acetolactate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44634", "l": "2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA + H(+) => (3,5-dihydroxyphenyl)acetyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605736", "l": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48929", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25060", "l": "(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) => (E)-cinnamate + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17292", "l": "beta-D-fructose 2,6-bisphosphate + H2O <=> beta-D-fructose 6-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14894", "l": "D-ornithine => (2R,4S)-2,4-diaminopentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16087", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine => ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018758", "l": "RHOH binds effectors at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018521", "l": "1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36361", "l": "2 a plastoquinol + O2 => 2 a plastoquinone + 2 H2O + 4 hnu"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12898", "l": "2-cis-(+)-abscisate + O2 + reduced [NADPH--hemoprotein reductase] => (+)-8'-hydroxyabscisate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53332", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 = 2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25038", "l": "ATP + L-seryl-tRNA(Sec) => ADP + O-phospho-L-seryl-tRNA(Sec)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848338", "l": "PNPLA4 hydrolyzes TAG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45372", "l": "H2O + N-(9Z-octadecenoyl)-sphinganine = (9Z)-octadecenoate + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63897", "l": "aspulvinone E + hnu => isoaspulvinone E"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062193", "l": "D-ribose pyranase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32011", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-T-muurolol + diphosphate"}, {"i": "EC:4.2.3.98", "l": "\"(+)-T-muurolol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37926", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627106", "l": "SMAC (DIABLO) forms dimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60917", "l": "a cytidine in mRNA + S-adenosyl-L-methionine => an N(3)-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730842", "l": "PI3K associates with phosphorylated GAB2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166175", "l": "TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58159", "l": "ATP + H2O + 4 Na(+)(in) <=> ADP + H(+) + 4 Na(+)(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53260", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 1beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381446", "l": "Thrombin proteolyzes IGF:IGFBP3:ALS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102392", "l": "decanoate-[HmqF protein] ligase activity"}, {"i": "MetaCyc:RXN-13623"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49502", "l": "GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+) => 2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58741", "l": "H2O + psi-UTP => diphosphate + H(+) + psi-UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981621", "l": "Neuroglobin:oxygen dissociates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59992", "l": "H(+) + oxidized [electron-transfer flavoprotein] + phloretate = (E)-4-coumarate + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31325", "l": "(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + GDP + H(+) => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34707", "l": "AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine = 5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane"}, {"i": "EC:4.7.1.1", "l": "\"Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66726", "l": "H2O + N-[(S)-lactoyl]-L-phenylalanine => (S)-lactate + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31340", "l": "acetate + ATP + holo-[ACP] => acetyl-[ACP] + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58872", "l": "24-methylidenelophenol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-937034", "l": "IRAK1 phosphorylates Pellino (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27432", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O <=> a 1,2-diacyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34748", "l": "15-methylhexadecasphinganine + ATP => 15-methylhexadecasphinganine 1-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5629218", "l": "HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 6xMeR-PIWIL2:piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987007", "l": "p-STAT1 dimerizes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62728", "l": "(+)-malbrancheamide B + bromide + FAD + 2 H(+) = (+)-malbrancheamide D + FADH2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097109", "l": "neuroligin family protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25289", "l": "lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46979", "l": "(S)-6-hydroxynicotine + O2 <=> 6-hydroxy-N-methylmyosmine + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19599", "l": "L-citrulline + NH4(+) => H2O + L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692129", "l": "Expression of PTGDS in testis differentiation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2464822", "l": "RDH12 reduces atRAL to atROL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12159", "l": "2-glutathionyl-2-methylbut-3-en-1-ol + H2O + 2 NAD(+) <=> 2-glutathionyl-2-methylbut-3-enoate + 3 H(+) + 2 NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036429", "l": "adenosylcobinamide kinase (ATP-specific) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424476", "l": "Activation of RAC1 by VAV2/3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43243", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12578", "l": "(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP => (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66894", "l": "10-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10030", "l": "2-oxoglutarate + H2O2 + NH4(+) => D-glutamate + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30772", "l": "guanosine + H2O => D-ribose + guanine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019776", "l": "Atg8 ligase activity"}, {"i": "REACT:R-HSA-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29294", "l": "(25S)-3-oxocholest-4-en-26-oate + ATP + CoA <=> (25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015200", "l": "methylammonium transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31018", "l": "H(+) + indole-3-carboxylate <=> CO2 + indole"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2243942", "l": "PDPK1 phosphorylates AKT1 E17K mutant (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866941", "l": "MID1IP1 binds THRSP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004113", "l": "2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"}, {"i": "RHEA:14489", "l": "a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 2'-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21858", "l": "6-hydroxycyclohex-1-ene-1-carbonyl-CoA => cyclohexa-1,5-diene-1-carbonyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050202", "l": "octopamine dehydratase activity"}, {"i": "MetaCyc:OCTOPAMINE-DEHYDRATASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953339", "l": "DNPH1 hydrolyses dGMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44971", "l": "(2E)-tetradecenoyl-CoA + H(+) + NADPH <=> NADP(+) + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.63"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626988", "l": "TNF-alpha:TNFR1 binds NSMAF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954082", "l": "E2F6 binds the PRC1 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046703", "l": "natural killer cell lectin-like receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426032", "l": "DAG is metabolized by DAGL to 2-AG (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44652", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a 1-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204824", "l": "Interaction of Tie2 and Ang4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58613", "l": "2 L-ascorbate + N-octanoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-octanoyl-(2S)-hydroxyglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49375", "l": "H(+) + NADH + O2 + protodeoxyviolaceinate <=> H2O + NAD(+) + protoviolaceinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.14.1", "l": "\"Yeast ribonuclease\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9626816", "l": "PIN1 binds p-S345-NCF1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21397", "l": "(S)-methylmalonyl-CoA + H(+)(out) + Na(+)(in) => CO2 + Na(+)(out) + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54349", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19967", "l": "acrylate + dimethyl sulfide + H(+) => S,S-dimethyl-beta-propiothetin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29002", "l": "H(+)(out) + homoserine lactone(in) <=> H(+)(in) + homoserine lactone(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047756", "l": "chondroitin 4-sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49501", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O => GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950782", "l": "p-STAT1 binds p-STAT3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34601", "l": "3-dehydro-15-methylhexadecasphinganine + H(+) + NADPH => 15-methylhexadecasphinganine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.226", "l": "\"N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58410", "l": "H(+) + NADPH + undecanal => NADP(+) + undecan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.29"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48657", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5229343", "l": "AXIN is phosphorylated in the destruction complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60870", "l": "a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(7)-methyl-GDP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30158", "l": "FADH2 + 2 Fe(3+) <=> FAD + 2 Fe(2+) + 3 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39204", "l": "(2E)-tetracosenoyl-CoA + H(+) + NADPH => NADP(+) + tetracosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68603", "l": "ORC5 binds ORC2:ORC3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0098634", "l": "cell-matrix adhesion mediator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023461", "l": "MECP2 T158A:SIN3A complex does not bind BDNF gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30647", "l": "1D-myo-inositol 3-phosphate + CTP + H(+) = CDP-1L-myo-inositol + diphosphate"}, {"i": "EC:2.7.7.74", "l": "\"1L-myo-inositol 1-phosphate cytidylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0004197", "l": "cysteine-type endopeptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71825", "l": "G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12340", "l": "L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] = H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672957", "l": "PP2A dephosphorylates KSR1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64659", "l": "(E)-sinapoaldehyde + CoA + NADP(+) <=> (E)-sinapoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50163", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 <=> N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690873", "l": "ACO1 binds 4Fe-4S (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29270", "l": "L-valine(in) + Na(+)(in) <=> L-valine(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26483", "l": "adenosine(37) in tRNA + dimethylallyl diphosphate => diphosphate + N(6)-dimethylallyladenosine(37) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-350769", "l": "trans-Golgi Network Coat Activation (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61829", "l": "stigmasterol + UDP-alpha-D-glucose => H(+) + stigmasteryl 3-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41415", "l": "1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40024", "l": "9alpha-copalyl diphosphate + H2O => diphosphate + syn-copalol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26182", "l": "1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate => 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814094", "l": "ARL1:GTP binds ARFIP2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866269", "l": "ARRB bind GPCRs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64746", "l": "3-sulfanyl-1-hexanol + NH4(+) + pyruvate => H2O + S-3-(hexan-1-ol)-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56225", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388831", "l": "Phosphorylation of CD28 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21414", "l": "dihydroxyacetone phosphate + H(+) + NADH => NAD(+) + sn-glycerol 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41868", "l": "decanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029473", "l": "Branching and elongation of mother and daughter filaments (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31854", "l": "(S)-2,3-epoxysqualene <=> parkeol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65034", "l": "3 a quinol + protoporphyrin IX => 3 a quinone + protoporphyrinogen IX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65292", "l": "2 ATP + butan-2-one + 3 H2O + hydrogencarbonate = 3-oxopentanoate + 2 AMP + 4 H(+) + 4 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57275", "l": "a 2'-deoxyguanosine in DNA + methylglyoxal <=> an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15637", "l": "[alginate](n) + GDP-alpha-D-mannuronate = [alginate](n+1) + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3341294", "l": "Superoxide reduces cytochrome c (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51022", "l": "2 [Fe(II)cytochrome c] + an aldehyde + 2 H(+) => 2 [Fe(III)cytochrome c] + a primary alcohol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41380", "l": "H(+) + NADH + O2 + toluene = 4-methylphenol + H2O + NAD(+)"}, {"i": "EC:1.14.13.236", "l": "\"Toluene 4-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938217", "l": "RUNX1 binds the SWI/SNF complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49954", "l": "5,10-dihydrophenazine 1-carboxylate => (10aS)-10,10a-dihydrophenazine-1-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42605", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61851", "l": "cholesterol + UDP-alpha-D-glucose <=> cholesteryl 3-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983834", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381377", "l": "Expression of KLF5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982778", "l": "Growth hormone binds the growth hormone receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35612", "l": "menadiol + 2 O2 => 2 H(+) + menadione + 2 superoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62744", "l": "H2O + mevastatin = (S)-2-methylbutanoate + compactin diol lactone + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44249", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35051", "l": "N,N'-diacetylchitobiose(out) = N,N'-diacetylchitobiose(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37889", "l": "H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide => S-adenosyl-L-methionine + small RNA 3'-end nucleotide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031725", "l": "CXCR6 chemokine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668831", "l": "CST complex formation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626953", "l": "TNF-alpha:TNFR1 binds DENN/MADD (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602484", "l": "Activation of proMMP11 by FURIN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48926", "l": "CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine => CMP-N-acetyl-beta-neuraminate + ganglioside GM4 (d18:1(4E))"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48893", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O => L-threonyl-[protein] + N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371554", "l": "HSF1 acetylation at Lys80 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18017", "l": "H(+) + indole-3-pyruvate = CO2 + indole-3-acetaldehyde"}, {"i": "EC:4.1.1.74", "l": "\"Indolepyruvate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102897", "l": "abietadienal hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193703", "l": "IKKbeta is activated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64676", "l": "3-(methylsulfanyl)propanoyl-CoA + butan-1-ol = butyl 3-(methylsulfanyl)propanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11907", "l": "2-amino-4-hydroxypteridine + H(+) + H2O <=> 2,4-dihydroxypteridine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5688294", "l": "SIRT5 deacetylates Cytochrome C (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786092", "l": "IL4:IL4R:JAK2 binds IL2RG:JAK3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13291", "l": "N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP => dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34866", "l": "2,3-didehydroadipyl-CoA + H2O <=> 3-hydroxyadipyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43049", "l": "keto-D-tagatose => keto-D-sorbose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38819", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17467", "l": "L-rhamnopyranose + quercetin => H2O + quercitrin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64464", "l": "L-tyrosyl-[protein] + 2 O2 = H(+) + H2O2 + L-topaquinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21314", "l": "CO2 + hydroquinone => 2,5-dihydroxybenzoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44986", "l": "CoA + O-3-methylbutanoyl-(R)-carnitine => (R)-carnitine + 3-methylbutanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102731", "l": "D-myo-inositol (1,3,4,6)-tetrakisphosphate 2-kinase activity"}, {"i": "MetaCyc:RXN-7185"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785245", "l": "Defective CYP11B2 does not oxidise CORST (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37865", "l": "1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396395", "l": "HSPG2 (perlecan) binds alpha-dystroglycan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34991", "l": "L-arginine(out) + L-ornithine(in) = L-arginine(in) + L-ornithine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786050", "l": "IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56166", "l": "(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19082", "l": "1-haloalkane + H2O => a halide anion + a primary alcohol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61164", "l": "kaempferol + UDP-beta-L-rhamnose = H(+) + kaempferol 3-O-alpha-L-rhamnoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937034", "l": "IRAK1 phosphorylates Pellino (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050507", "l": "indoxyl-UDPG glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052849", "l": "NADPH-dependent curcumin reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375135", "l": "Basigin binds Matrix metalloproteinase-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204600", "l": "Basigin homodimerises (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.n2", "l": "\"Peptidoglycan lytic endotransglycosylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25370", "l": "3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NADP(+) <=> H(+) + momilactone A + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389523", "l": "BTLA interacts with HVEM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54909", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH => (4E)-hexenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57277", "l": "a 2'-deoxyguanosine in DNA + glyoxal => an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8940561", "l": "MMP7 cleaves OPTC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061627", "l": "S-methylmethionine-homocysteine S-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102724", "l": "UDP-glucose:curcumin monoglucoside glucosyltransferase activity"}, {"i": "MetaCyc:RXN-7063"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33788", "l": "3'-ketolactose + H2O => 3-keto-beta-D-galactose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46792", "l": "2 [Fe(II)-cytochrome b5] + an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35404", "l": "(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+) => (3R)-vestitone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50521", "l": "acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661230", "l": "MT1A binds arsenic (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41303", "l": "H2O + N-dodecanoyl-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + dodecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59862", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->6)-N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP => 3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31660", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GlcpNAc + H2O => 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57639", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + ML-236A carboxylate <=> holo-[2-methylbutanoate polyketide synthase] + mevinic carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60274", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39942", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36303", "l": "a fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25477", "l": "(2E,6E)-farnesyl diphosphate => alpha-himachalene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390886", "l": "HRH4 binds Hist (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24353", "l": "ethyl (R)-3-hydroxyhexanoate + NADP(+) => ethyl 3-oxohexanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2467794", "l": "Resolution of sister chromatids (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23921", "l": "(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052624", "l": "2-phytyl-1,4-naphthoquinone methyltransferase activity"}, {"i": "MetaCyc:RXN-6723"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-376419", "l": "Formation of NR-MED1 Coactivator Complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035979", "l": "histone kinase activity (H2A-S139 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651782", "l": "FEN1 bound to POLB cleaves displaced DNA strand (flap) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015334", "l": "high-affinity oligopeptide transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045142", "l": "triplex DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50335", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202721", "l": "JAM2 binds JAM3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140550", "l": "phosphatidylinositol-4,5-bisphosphate sensor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62319", "l": "salicylate + UDP-alpha-D-glucose <=> 1-O-salicyl-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805507", "l": "APAF1 binds AVEN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47283", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071567", "l": "UFM1 hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47219", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxyestradiol-17beta + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604368", "l": "Autocatalytic activation of bound proMMP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444100", "l": "PROT mediates L-proline uptake (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983307", "l": "IL15 binds IL15RA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196017", "l": "Dynamin is recruited to the gap junction plaque (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010011", "l": "auxin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19127", "l": "3-hydroxypyruvate + glycine => glyoxylate + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28453", "l": "N(6)-(D-psicosyl)-L-lysine(in) <=> N(6)-(D-psicosyl)-L-lysine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698043", "l": "FLT3 ITD- and STAT5-dependent CDKN1A gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-481044", "l": "Surface deployment of platelet alpha granule membrane components (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51379", "l": "dopamine + hexadecanoyl-CoA <=> CoA + H(+) + N-hexadecanoyl-dopamine"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0043394", "l": "proteoglycan binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15561", "l": "S-adenosyl-L-methionine + sterigmatocystin = 8-O-methylsterigmatocystin + H(+) + S-adenosyl-L-homocysteine"}, {"i": "RHEA:35767", "l": "dihydrosterigmatocystin + S-adenosyl-L-methionine = 8-O-methyldihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.110", "l": "\"Sterigmatocystin 8-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55511", "l": "cucurbitadienol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 11-oxocucurbitadienol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60568", "l": "N-acetyl-L-tryptophan = N-acetyl-D-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20858", "l": "a fatty acid + sphing-4-enine => an N-acylsphing-4-enine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60287", "l": "N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24760", "l": "H(+) + L-dopa + NADH = 3-(3,4-dihydroxyphenyl)propanoate + NAD(+) + NH4(+)"}, {"i": "EC:4.3.1.22", "l": "\"3,4-dihydroxyphenylalanine reductive deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3244643", "l": "STING binds cyclic GMP-AMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928627", "l": "EPHB phosphorylates TIAM1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25970", "l": "benzil + H(+) + NADPH => (S)-benzoin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44970", "l": "NADP(+) + tetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48117", "l": "L-arginyl-[protein] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114254", "l": "CYCS binds to APAF1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12377", "l": "ATP + L-fuculose => ADP + H(+) + L-fuculose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033996", "l": "levan fructotransferase (DFA-IV-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.2.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66058", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-tryptophan => indole-3-pyruvate + L-kynurenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23727", "l": "H2O + O2 + pyridoxal <=> 4-pyridoxate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805811", "l": "Release of SEPT4 from mitochondria (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31641", "l": "H(+) + mycinamicin IV + S-adenosyl-L-homocysteine => mycinamicin III + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0016825", "l": "hydrolase activity, acting on acid phosphorus-nitrogen bonds"}, {"i": "EC:3.9.1.-", "l": "\"Acting on phosphorus-nitrogen bonds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54805", "l": "2 4-sulfanylbutanoate + NAD(+) => 4,4'-disulfanyldibutanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2404142", "l": "atROL binds RBP1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24762", "l": "3-(3,4-dihydroxyphenyl)propanoate + NAD(+) + NH4(+) => H(+) + L-dopa + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388809", "l": "CTLA-4 binds B7-1/B7-2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29578", "l": "L-serine(in) + Na(+)(in) <=> L-serine(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44055", "l": "alpha,alpha-trehalose + hexadecanoyl-CoA <=> 2-O-hexadecanoyl-alpha,alpha-trehalose + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31400", "l": "all-trans-4,4'-diapophytofluene + FAD + H(+) => all-trans-4,4'-diapo-zeta-carotene + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.282", "l": "\"Quinate/shikimate dehydrogenase (NAD(P)(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34729", "l": "15-methylhexadecasphinganine + a carboxylate => H2O + N-acyl-15-methylhexadecasphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54653", "l": "peregrinol diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20560", "l": "2 H(+) + H2O + urea <=> CO2 + 2 NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33520", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + sphinganine => (4R)-hydroxysphinganine + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46353", "l": "(2E)-decenoyl-CoA + H2O => 3-hydroxydecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41127", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791109", "l": "GADD45A binds PCNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30048", "l": "chloroacetaldehyde + H2O + NAD(+) => chloroacetate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51977", "l": "an L-N-hydroxypolyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => an L-N,N-dihydroxypolyhomomethionine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691150", "l": "TFR2 dimer binds 2xholoTF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698754", "l": "p-STAT5 binds the NOX4 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63963", "l": "abscisate(out) + ATP + H2O <=> abscisate(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23557", "l": "D-alanine + L-glutamine => gamma-L-glutamyl-D-alanine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13220", "l": "H2O + NAD(+) + succinate semialdehyde <=> 2 H(+) + NADH + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62709", "l": "(indol-3-yl)butanoate + UDP-alpha-D-glucose => 4-(indol-3-yl)butanoyl-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177942", "l": "EGFR binds EGF ligand (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036479", "l": "peroxidase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22480", "l": "4-(hydroxyamino)quinoline N-oxide + H2O + 2 NAD(+) = 4-nitroquinoline N-oxide + 2 H(+) + 2 NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003831", "l": "beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69116", "l": "Formation of Okazaki fragments (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9010872", "l": "SLIT2 binds Dystroglycan (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004790", "l": "thioether S-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177926", "l": "Dephosphorylation of PAG by SHP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56091", "l": "CMP-N-acetyl-beta-neuraminate + globoside MSGG <=> CMP + globoside DSGG + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606151", "l": "Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14629", "l": "ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate"}, {"i": "EC:2.7.2.8", "l": "\"Acetylglutamate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110215", "l": "Cleavage of uracil by UNG glycosylase (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33126", "l": "all-trans-heptaprenyl diphosphate <=> (R)-tetraprenyl-beta-curcumene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0016743", "l": "carboxyl- or carbamoyltransferase activity"}, {"i": "EC:2.1.3.-", "l": "\"Carboxy- and carbamoyltransferases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60397", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O => Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18604", "l": "3,4-dihydroxyphthalate + H(+) <=> 3,4-dihydroxybenzoate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955822", "l": "RUNX1 binds the SOCS4 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41072", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55815", "l": "a bacteriochlorophyllide d + H2O + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + a bacteriochlorophyllide f + 2 H(+) + 2 L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607757", "l": "K63polyUb-TRAF6 ubiquitinates TAK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5679205", "l": "ULK1 phosphorylates Beclin-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.16"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662466", "l": "XYLB phosphorylates D-xylulose (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0030561", "l": "RNA 2'-O-ribose methylation guide activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70479", "l": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694583", "l": "ABHD4 hydrolyses NAPE (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34088", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + cholesterol => a 1-acyl-sn-glycero-3-phosphocholine + a cholesterol ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807872", "l": "Active ARF recruits coatomer (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158982", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43989", "l": "(2E,6E)-farnesyl diphosphate + H(+) + NADPH + O2 => (2E,6E)-omega-hydroxy-farnesyl diphosphate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010698", "l": "acetyltransferase activator activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062202", "l": "Labd-13(16),14-diene-9-ol synthase activity"}, {"i": "RHEA:62184", "l": "peregrinol diphosphate = diphosphate + labd-13(16),14-diene-9-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21035", "l": "glucuronate acceptor + UDP-alpha-D-glucuronate <=> acceptor beta-D-glucuronoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203774", "l": "Interaction of Csk with PAG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18648", "l": "2 putrescine <=> NH4(+) + sym-homospermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38983", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51649", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] + O2 => (S)-2-amino-6-oxohexanoyl-[protein] + acetamide + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102869", "l": "6-hydroxyflavone-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-8354"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666169", "l": "Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030946", "l": "protein tyrosine phosphatase activity, metal-dependent"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45882", "l": "4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA => 3-methylundecanoyl-CoA + 2 H(+) + 2 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220982", "l": "NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69140", "l": "RPA binds to the Flap (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051751", "l": "alpha-1,4-mannosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0004875", "l": "complement receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696275", "l": "RND2 binds GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35827", "l": "H2O + N(1)-aminopropylagmatine = spermidine + urea"}, {"i": "EC:3.5.3.24", "l": "\"N(1)-aminopropylagmatine ureohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54094", "l": "2,4,5-trihydroxyphenylacetate + H2O + NADP(+) => 3,4-dihydroxyphenylacetate + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814695", "l": "PERP binds desmosomes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450466", "l": "AUF1:mRNA complex is destroyed (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050056", "l": "linalool 8-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39538", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA <=> (2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102529", "l": "apigenin 7-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-14661"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139905", "l": "Translocation of activated BAD protein to mitochondria (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209828", "l": "Tryptophan is hydroxylated (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034189", "l": "very-low-density lipoprotein particle binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18158", "l": "ATP + pyruvate => ADP + H(+) + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938121", "l": "SERPINB13 binds CTSK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202718", "l": "Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51159", "l": "ATP + L-glutamate + tRNA(Glu) <=> AMP + diphosphate + L-glutamyl-tRNA(Gln)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45564", "l": "2-epi-5-epi-valiolone = 5-epi-valiolone"}, {"i": "EC:5.1.3.33", "l": "\"2-epi-5-epi-valiolone epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46989", "l": "(R)-6-hydroxynicotine + O2 => 6-hydroxy-N-methylmyosmine + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58186", "l": "(14E,18E)-lycopadiene + 2 diphosphate + NADP(+) => H(+) + NADPH + 2 phytyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65382", "l": "a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidyl-adenosine in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidyl-adenosine in mRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48816", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420117", "l": "VEGFR2 autophosphorylates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15153", "l": "4-hydroxybenzoate + UDP-alpha-D-glucose = 4-(beta-D-glucosyloxy)benzoate + H(+) + UDP"}, {"i": "EC:2.4.1.194", "l": "\"4-hydroxybenzoate 4-O-beta-D-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28907", "l": "3-(3-hydroxyphenyl)propanoate(in) + H(+)(in) = 3-(3-hydroxyphenyl)propanoate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57880", "l": "3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-alpha-D-xylose = 3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848864", "l": "PTK6 binds ARAP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987120", "l": "JAK1 binds IFNLR1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948226", "l": "Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29770", "l": "ATP + D-methionine(out) + H2O <=> ADP + D-methionine(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49563", "l": "D-sedoheptulose 7-phosphate <=> (R)-demethyl-4-deoxygadusol + H(+) + H2O + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102338", "l": "3-oxo-lignoceronyl-CoA synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42194", "l": "(9Z,12Z)-pentadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (9Z)-pentadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17551", "l": "1-acyl-2-(10-methylene)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine => 1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31344", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H2O => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6805640", "l": "AKT phosphorylates KAT6A (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33408", "l": "ATP + glycine + H(+) => diphosphate + glycyl-5'-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13135", "l": "CDP + dolichyl phosphate + H(+) => CTP + di-trans,poly-cis-dolichol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10262", "l": "ADP + H(+) + Mg(2+)(in) + phosphate => ATP + H2O + Mg(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57031", "l": "FADH2 + N-methylnicotinate + O2 <=> (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55749", "l": "coenzyme B + coenzyme M + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45503", "l": "[allophycocyanin beta-subunit]-Cys(84)-phycocyanobilin <=> (2R,3E)-phycocyanobilin + apo-[allophycocyanin beta-subunit]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22967", "l": "H(+) + L-ornithine <=> CO2 + putrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55887", "l": "[aequorin] + 3 Ca(2+) <=> [aequorin]--dioxetanone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47207", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30967", "l": "9,9',15-tri-cis-zeta-carotene = 9,9'-di-cis-zeta-carotene"}, {"i": "EC:5.2.1.12", "l": "\"Zeta-carotene isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2002460", "l": "P4HB binds Collagen chains (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070039", "l": "rRNA (guanosine-2'-O-)-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23081", "l": "L-rhamnonate => 2-dehydro-3-deoxy-L-rhamnonate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17071", "l": "all-trans-undecaprenyl phosphate + H(+) + phosphate => all-trans-undecaprenyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-376851", "l": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.43", "l": "\"Phosphogluconate 2-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41800", "l": "acetyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54715", "l": "N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55213", "l": "(2R)-hydroxyhexadecanoyl-CoA => formyl-CoA + pentadecanal"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990275", "l": "preribosome binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40959", "l": "2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54048", "l": "(2E,6E)-farnesyl diphosphate + H2O = 4-epi-cubebol + diphosphate"}, {"i": "EC:4.2.3.170", "l": "\"4-epi-cubebol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58194", "l": "dihydrobisanhydrobacterioruberin + diphosphate => dimethylallyl diphosphate + H2O + isopentenyldehydrorhodopin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112342", "l": "Inactivation of MAP2K1 by CDK1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72180", "l": "Cleavage of mRNA at the 3'-end (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031071", "l": "cysteine desulfurase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74734", "l": "Re-integration of insulin receptor into plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623072", "l": "POMC gene expression is inhibited by FOXO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13738", "l": "an n-alkanal + NADP(+) => an alk-2-enal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382061", "l": "Extracellular processing of novel PDGFs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45538", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-octadecanoyl ethanolamine => H2O + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57660", "l": "(+)-valencene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (+)-nootkatone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26293", "l": "(1'S,5'S)-averufin + NADPH + O2 = 1'-hydroxyversicolorone + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.14"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349426", "l": "Phosphorylation of MDM4 by CHEK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65462", "l": "CoA + hexyl acetate => acetyl-CoA + hexan-1-ol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042799", "l": "histone methyltransferase activity (H4-K20 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57854", "l": "2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase => a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202534", "l": "Ubiquitination of NEMO by TRAF6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16973", "l": "2-hydroxypyridine + AH2 + O2 = 2,5-dihydroxypyridine + A + H2O"}, {"i": "EC:1.14.99.26", "l": "\"2-hydroxypyridine 5-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13699", "l": "ADP + D-ribose 5-phosphate + H(+) => ATP + D-ribose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61030", "l": "S-(2,3-dicarboxypropyl)-L-cysteinyl-[protein] => itaconate + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11215", "l": "indole + O2 <=> 2-formamidobenzaldehyde"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062104", "l": "pumilio-response element binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57183", "l": "L-lysyl-[protein] + methylglyoxal <=> N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0030558", "l": "RNA pseudouridylation guide activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74615", "l": "PRKCA/Q phosphorylate RGS9-1:GN5B:RGS9BP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191784", "l": "snRNA Cap hypermethylation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27653", "l": "GTP + uridine <=> GDP + H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49504", "l": "phosphinomethylmalate = phosphinomethylisomalate"}, {"i": "EC:4.2.1.166", "l": "\"Phosphinomethylmalate isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2730872", "l": "Activation of Calcineurin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047867", "l": "dimethylmalate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29230", "l": "H(+)(in) + indole(in) <=> H(+)(out) + indole(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66823", "l": "ATP + H2O + Mn(2+)(in) <=> ADP + H(+) + Mn(2+)(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2214351", "l": "PLK1 phosphorylates GORASP1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189062", "l": "lactose + H2O => D-glucose + D-galactose (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41976", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) = CMP + ganglioside GQ1b alpha (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663752", "l": "KCNN2 transports K+ from the cytosol to the extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14914", "l": "AMP + thymidine => adenosine + dTMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51154", "l": "3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide => 2 a thiol + L-cysteinyl-[sulfatase] + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0140612", "l": "DNA damage sensor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65419", "l": "dGMP(in) + NAD(+)(out) <=> dGMP(out) + NAD(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668904", "l": "Formation of the CTF18 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38053", "l": "1-butyryl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-481009", "l": "Exocytosis of platelet dense granule content (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23909", "l": "2 [methionine synthase]-methylcob(III)alamin + H(+) + NADP(+) + 2 S-adenosyl-L-homocysteine => 2 [methionine synthase]-cob(II)alamin + NADPH + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37943", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66904", "l": "A + cannabinerolate = AH2 + cannabichromenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10842", "l": "L-threonine + phosphate => H2O + O-phospho-L-homoserine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32554", "l": "(2E)-geranyl diphosphate + H2O <=> (S)-alpha-terpineol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50545", "l": "prostaglandin C2 => prostaglandin B2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77081", "l": "Formation of the CE:GMP intermediate complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218847", "l": "PAK2 binds NCK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604719", "l": "NOTCH4 gene transcription is inhibited by RUNX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483089", "l": "PE is converted to PS by PTDSS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27777", "l": "2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31372", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine => (2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3791319", "l": "NID1 degradation by MMP19 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19392", "l": "(E)-ferulate + ATP + CoA <=> (E)-feruloyl-CoA + ADP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48579", "l": "4-chlorocatechol + O2 <=> 3-chloro-cis,cis-muconate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110215", "l": "Cleavage of uracil by UNG glycosylase (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632892", "l": "TP53 stimulates transcription of RRM2B gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34277", "l": "3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + H(+) + L-methionine => 2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987039", "l": "JAK1 binds IL20RA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031703", "l": "type 2 angiotensin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444606", "l": "T1R2/T1R3 dimer is a sweet taste receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25922", "l": "7-hydroxyquinolin-2(1H)-one + AH2 => A + H2O + quinolin-7-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903875", "l": "corticosterone binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004821", "l": "histidine-tRNA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62144", "l": "dGMP + dGTP = 2 dGDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981892", "l": "Active G alpha (z) binds RGS proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036068", "l": "Defective GUSB does not hydrolyse GlcA-β1,3-GlcNAc (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2172678", "l": "PHF8 demethylates histone H4K20me1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16987", "l": "H(+) + maleylacetate + NADPH => 3-oxoadipate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59130", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + AMP + diphosphate => (S)-2,3-diaminopropanoate + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65356", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54285", "l": "H2O + N-(octadecanoyl)-sphing-4-enine-1-phosphocholine => H(+) + N-octadecanoylsphing-4-enine + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102916", "l": "sesamin synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028598", "l": "Phosphorylation of YAP by LATS1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32204", "l": "(R)-synephrine => (4-hydroxyphenyl)acetaldehyde + methylamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008465", "l": "glycerate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9650473", "l": "SERPING1 is secreted (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43152", "l": "adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.220", "l": "\"tRNA (adenine(58)-N(1))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32501", "l": "(1S,3R,5S)-sabinol + H2O + NADP(+) => (1R,5R)-sabinene + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30665", "l": "hapalindole H => 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018535", "l": "nicotine dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730882", "l": "Phosphorylation of PKC-theta (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44408", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6795667", "l": "MDM2 translocates to the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36981", "l": "3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + CO2 + CoA => (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13814", "l": "benzene + H(+) + NADH + O2 => cis-1,2-dihydrobenzene-1,2-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8963851", "l": "VD3 dissociates from GC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58001", "l": "(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose => (20S)-ginsenoside Rg3 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176879", "l": "apolipoprotein(a) + LDL => Lp(a) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36088", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40309", "l": "(2E)-decenedioyl-CoA + AH2 => A + decanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28552", "l": "CoA + N-acetylanthranilate => acetyl-CoA + anthranilate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114671", "l": "vWF binds to collagen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.22.2", "l": "\"Aspergillus deoxyribonuclease K(1)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "75.582117822819498", "identifiers": [{"i": "GO:0005402", "l": "carbohydrate:cation symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59104", "l": "chenodeoxycholate + dolichyl beta-D-glucosyl phosphate = beta-D-glucosyl-(1->3)-O-chenodeoxycholate + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37736", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine => 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30352", "l": "H(+) + NADH + O2 + pyrrole-2-carboxylate => 5-hydroxypyrrole-2-carboxylate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004940", "l": "beta1-adrenergic receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023617", "l": "Butyrylcholinesterase hydrolyzes acyl Ghrelin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29264", "l": "L-leucine(in) + Na(+)(in) => L-leucine(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782890", "l": "LCMT2 methoxycarbonylates yW-58 yielding yW (wybutosine) at nucleotide 37 of tRNA(Phe) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807578", "l": "GNLY binds the bacterial cell surface in the phagosome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63767", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19232", "l": "AMP + an aromatic aldehyde + diphosphate + NADP(+) <=> an aromatic carboxylate + ATP + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55407", "l": "[phosphate](n) + UTP <=> [phosphate](n+1) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661419", "l": "ALB binds extracellular heme (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696275", "l": "RND2 binds GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.2", "l": "\"Carboxypeptidase B\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1471322", "l": "Beta-defensins are secreted (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67138", "l": "3-hydroxypropanoyl-CoA + ADP + phosphate => 3-hydroxypropanoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444572", "l": "Zinc is an agonist of GPR39 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63939", "l": "3 a ubiquinone + protoporphyrinogen IX <=> 3 a ubiquinol + protoporphyrin IX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944225", "l": "Association of procollagen type XVII (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418850", "l": "Activation of Cdc42 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41370", "l": "1-O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-tetradecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55013", "l": "(1S,4R)-1-hydroxylimonen-2-one + NADPH + O2 => (3R)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114563", "l": "Collagen type I binds integrin alpha1beta1, alpha2beta1, alpha10beta1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052595", "l": "aliphatic-amine oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61172", "l": "myricetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = H(+) + myricetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295516", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38795", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944216", "l": "Association of procollagen type XV (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28072", "l": "diphosphate + Fe(II)-heme o => (2E,6E)-farnesyl diphosphate + H2O + heme b"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004476", "l": "mannose-6-phosphate isomerase activity"}, {"i": "MetaCyc:MANNPISOM-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009374", "l": "biotin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14672", "l": "D-glyceraldehyde 3-phosphate + H2O + NADP(+) <=> (2R)-3-phosphoglycerate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44433", "l": "2 a 1-acylglycerol => a 1,2-diacylglycerol + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29122", "l": "a ubiquinol + nitrate <=> a ubiquinone + H2O + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334160", "l": "UHRF1:Chromatin binds DNMT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613202", "l": "EGR1 and NAB co-repressors bind EGR1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202721", "l": "JAM2 binds JAM3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16065", "l": "2-oxoglutarate + O2 + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO2 + succinate"}, {"i": "EC:1.14.11.18", "l": "\"Phytanoyl-CoA dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:1902271", "l": "D3 vitamins binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11147", "l": "GDP-alpha-D-mannose <=> GDP-beta-L-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.64"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14808", "l": "ATP + D-allose <=> ADP + D-allose 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374665", "l": "DCC interaction with SIAH1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9724090", "l": "MYH9- and RNF213-ALK fusions are phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13953", "l": "a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + H(+) + tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18253", "l": "(S)-malate + NADP(+) = CO2 + NADPH + pyruvate"}, {"i": "EC:1.1.1.40", "l": "\"Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033204", "l": "ribonuclease P RNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54950", "l": "(2E,5Z)-dodecadienoyl-[ACP] + H2O => (3R)-hydroxy-(5Z)-dodecenoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52909", "l": "3-dimethylallyl-4-hydroxyphenylpyruvate + O2 => 3-dimethylallyl-4-hydroxymandelate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25925", "l": "A + H2O + quinolin-8-ol => 8-hydroxyquinolin-2(1H)-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805470", "l": "AMPK phosphorylates TP53 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218812", "l": "FYN phosphorylates PAK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26332", "l": "(S)-8-amino-7-oxononanoate + L-lysine <=> (7R,8S)-7,8-diammoniononanoate + (S)-2-amino-6-oxohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199839", "l": "AKT can phosphorylate RSK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54771", "l": "[LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine <=> [LarE protein]-dehydroalanine + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29580", "l": "Fe(2+)(in) + H(+)(in) => Fe(2+)(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16597", "l": "ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209075", "l": "Destabilisation and degradation of AXN in the 'destruction complex' (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0022810", "l": "membrane potential driven uniporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17595", "l": "2-oxoglutaramate + L-phenylalanine => 3-phenylpyruvate + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66266", "l": "diphosphate + nonanoyl-AMP => ATP + H(+) + nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46361", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016937", "l": "short-branched-chain-acyl-CoA dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1297333", "l": "Association of Acrosin Heavy and Light Chain (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730840", "l": "Activation of RAC1 by VAV (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22170", "l": "UDP-alpha-D-galactose => UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17643", "l": "agmatine + CO2 => H(+) + L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863014", "l": "p25-bound CDK5 phosphorylates CDC25A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161962", "l": "LTA4 is hydrolysed to 6t-/6t,12epi-LTB4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39312", "l": "(8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8986083", "l": "USP33 deubiquitinates ROBO1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53468", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine + cholesterol = (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0008408", "l": "3'-5' exonuclease activity"}, {"i": "REACT:R-HSA-3245943", "l": "Viral DNA cleavage by TREX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24138", "l": "a sulfamate + adenosine 3',5'-bisphosphate + 2 H(+) => 3'-phosphoadenylyl sulfate + a primary amine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12721", "l": "putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine"}, {"i": "EC:2.5.1.16", "l": "\"Spermidine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30132", "l": "H2O + octanoyl-[ACP] => H(+) + holo-[ACP] + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53115", "l": "3alpha-hydroxy-5alpha-androstane 17-O-(beta-D-glucuronate) + NADP(+) <=> 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48522", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + H(+) + methanol => [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798748", "l": "Exocytosis of secretory granule lumen proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18190", "l": "[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose => [(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620197", "l": "HSPA8:Substrate binds LAMP2a (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71495", "l": "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626982", "l": "TNF-alpha:TNFR1:NSMAF binds GNB2L1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046547", "l": "trans-aconitate 3-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030756", "l": "isoorientin 3'-O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050209", "l": "polyvinyl-alcohol oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617815", "l": "BBSome binds RAB3IP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396594", "l": "Phosphorylation of SLP-76 by p-SYK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32643", "l": "2 [Fe(III)cytochrome c] + H2O + lupanine = 17-hydroxylupanine + 2 [Fe(II)cytochrome c] + 2 H(+)"}, {"i": "EC:1.17.2.2", "l": "\"Lupanine 17-hydroxylase (cytochrome c)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047213", "l": "anthocyanidin 3-O-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39388", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA => (2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043879", "l": "glycolate transmembrane transporter activity"}, {"i": "RHEA:29447", "l": "glycolate(in) = glycolate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202394", "l": "Translocation of CARMA1 to Plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30776", "l": "H2O + O2 + pyridoxamine => H2O2 + NH4(+) + pyridoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58955", "l": "(20S)-protopanaxatriol + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rh1 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11726", "l": "3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol => [thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30698", "l": "3-aminopropanal + H2O + NAD(+) <=> beta-alanine + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2173778", "l": "MSR1 (SCARA1, SR-A) binds ligands (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37344", "l": "adenosine 2'-phosphate + H2O => adenosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56001", "l": "H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] => beta-D-glucose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32326", "l": "ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> ent-kaur-16-en-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810234", "l": "General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16634", "l": "guanosine(34) in tRNA + queuine => guanine + queuosine(34) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983996", "l": "STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37419", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18264", "l": "H2O + precorrin-5 + S-adenosyl-L-methionine <=> acetate + 2 H(+) + precorrin-6A + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189069", "l": "sucrose + H2O => glucose + fructose (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798257", "l": "PTPRS binds NTRK3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50712", "l": "chloride + FADH2 + O2 + tetracycline = 7-chlorotetracycline + FAD + H(+) + 2 H2O"}, {"i": "EC:1.14.19.49", "l": "\"Tetracycline 7-halogenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0035312", "l": "5'-3' exodeoxyribonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23561", "l": "adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate => adenosylcob(III)alamin 5'-phosphate + GMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004719", "l": "protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19023", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP => an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64825", "l": "1-naphthaleneacetamide + H2O => 1-naphthaleneacetate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21508", "l": "all-trans-retinyl hexadecanoate + H2O = H(+) + hexadecanoate + retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59055", "l": "D-lysine + H(+) <=> cadaverine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39652", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O => 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047981", "l": "histidine N-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23138", "l": "a methylated primary amine + H(+) + S-adenosyl-L-homocysteine => a primary amine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1564169", "l": "Collagen type VIII degradation by MMP1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9609921", "l": "SGTA binds Tail-anchored protein (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32025", "l": "avermitilol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690988", "l": "3'-incision of DNA by ERCC5 (XPG) in GG-NER (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.108", "l": "\"Nocturnin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36053", "l": "2 beta-L-arabinofuranose => beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875817", "l": "MET phosphorylates STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1067659", "l": "Assembly of hexameric IL-6 receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68595", "l": "ORC2 binds ORC3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948066", "l": "K63polyUb-IRAK1 dissociates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9681375", "l": "KIT binds ripretinib (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388900", "l": "Neurotensin receptors can bind neurotensins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381087", "l": "Dimerization of PERK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670114", "l": "Histone H3.3 deposition at telomere (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49360", "l": "2',2'-dihydroxy-2-oxospirilloxanthin = 2,2'-dioxospirilloxanthin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49550", "l": "H(+) + L-arginyl-[protein] + lactate => H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75862", "l": "Fall Back to Closed Pre-initiation Complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18241", "l": "D-lysine = (2R,5S)-2,5-diaminohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.52", "l": "\"[3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63476", "l": "NADP(+) + prostaglandin E2 = 15-oxoprostaglandin E2 + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5683925", "l": "ULK1 is dephosphorylated (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086089", "l": "voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987120", "l": "JAK1 binds IFNLR1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30996", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoradiol => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + soyasapogenol B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46843", "l": "4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.70", "l": "\"Pancreatic endopeptidase E\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043199", "l": "sulfate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51762", "l": "a 2-acyl-4,6,6-triprenylphloroglucinol + diphosphate => a 2-acyl-4,6-diprenylphloroglucinol + dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395764", "l": "atREs binds to nascent CM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20493", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}, {"i": "EC:2.4.1.244", "l": "\"N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60090", "l": "a 4alpha-methyl-3-oxosteroid + CO2 + NADPH => a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26401", "l": "all-trans-10'-apo-beta-carotenal + O2 = (2E,4E,6E)-4-methylocta-2,4,6-trienedial + 13-apo-beta-carotenone"}, {"i": "EC:1.13.11.70", "l": "\"All-trans-10'-apo-beta-carotenal 13,14-cleaving dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983161", "l": "Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32958", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015591", "l": "D-ribose transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001082", "l": "inulin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.2"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015417", "l": "ABC-type polyamine transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61940", "l": "3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + UDP-alpha-D-glucose = 3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17138", "l": "prostaglandin H2 => thromboxane A2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70899", "l": "histidine => urocanate + NH4+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "75.848614326174683", "identifiers": [{"i": "GO:0004521", "l": "endoribonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201639", "l": "Caspase-mediated cleavage of GAS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004586", "l": "ornithine decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54469", "l": "1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051065", "l": "CTP reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9609310", "l": "β-blockers bind ADRB1,2,3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24048", "l": "phosphate + sucrose = alpha-D-glucose 1-phosphate + D-fructose"}, {"i": "EC:2.4.1.7", "l": "\"Sucrose phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64678", "l": "butyl 3-(methylsulfanyl)propanoate + CoA => 3-(methylsulfanyl)propanoyl-CoA + butan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56043", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34852", "l": "(3S)-3-hydroxyadipyl-CoA + NAD(+) => 3-oxoadipyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653974", "l": "Ragulator binds Rag dimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11743", "l": "2 glutathione + NADP(+) <=> glutathione disulfide + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210646", "l": "Phosphorylated STAT92E dimer is dephosphorylated by PTP61F isoform 1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51876", "l": "2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate = desmethylxanthohumol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55509", "l": "cucurbitadienol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 11-oxocucurbitadienol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729279", "l": "Nucleoprotein is ADP-ribosylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396399", "l": "Fibrillins bind BMPs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944265", "l": "Association of procollagen type IV (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70427", "l": "PGM:Mg2+ isomerise G1P to G6P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58901", "l": "1-carboxybiuret + H2O => NH4(+) + urea-1,3-dicarboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9028730", "l": "Activated NTRK2 binds FRS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030782", "l": "(S)-tetrahydroprotoberberine N-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10470", "l": "acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O => D-xylulose 5-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16855", "l": "AMP + fumarate => N(6)-(1,2-dicarboxyethyl)-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1454916", "l": "The ABCC family mediates organic anion transport (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193715", "l": "5beta-cholestan-3alpha,7alpha,24(S)-triol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617458", "l": "HOXA1 mRNA is translated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790087", "l": "HVEM induses BTLA phosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018590", "l": "methylsilanetriol hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47172", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NAD(+) = 5alpha-cholest-8-en-3-one + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140393", "l": "norsolorinic acid ketoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013435", "l": "RHOD auto-activates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37442", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate <=> a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937079", "l": "MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16225", "l": "1,8-diazacyclotetradecane-2,9-dione + H2O = N-(6-aminohexanoyl)-6-aminohexanoate"}, {"i": "EC:3.5.2.12", "l": "\"6-aminohexanoate-cyclic-dimer hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49398", "l": "20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28573", "l": "ATP + L-serine <=> diphosphate + L-seryl-5'-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13556", "l": "alpha-D-galactose + ATP <=> ADP + alpha-D-galactose 1-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42430", "l": "(3R,5R)-clavulanate-9-aldehyde => clavaminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66429", "l": "D-arabinose(out) + H(+)(out) => D-arabinose(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37768", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15521", "l": "N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein]"}, {"i": "EC:2.3.1.97", "l": "\"Glycylpeptide N-tetradecanoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5225649", "l": "RBBP7 binds histone H3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41419", "l": "1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24330", "l": "10-formyldihydrofolate + ADP + phosphate => 7,8-dihydrofolate + ATP + formate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373342", "l": "CX3CR1 binds CX3CL1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38700", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70592", "l": "PXLP-K259-GOT1 dimer deaminates L-Asp (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42376", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878654", "l": "ACP6 hydrolyses MYS-LPA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74707", "l": "Binding of IRS to insulin receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202164", "l": "Translocation of PDK1 to Plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37140", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate => 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52114", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate => 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24995", "l": "L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664270", "l": "Recruitment of PLCgamma to membrane due to FCGR3A effect (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022818", "l": "sodium ion uniporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14089", "l": "2-oxoglutarate + glycine = glyoxylate + L-glutamate"}, {"i": "EC:2.6.1.4", "l": "\"Glycine transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39835", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58971", "l": "1-naphthaldehyde + H2O + O2 <=> 1-naphthoate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65251", "l": "AH2 + 5 H(+) + 5 malonyl-CoA <=> 6-hydroxymellein + A + 5 CO2 + 5 CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14241", "l": "3-amino-4-hydroxybenzaldehyde + acetyl-CoA = 3-acetylamino-4-hydroxybenzaldehyde + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875451", "l": "MET phosphorylates CBL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805022", "l": "USP2 binds the heterodimer of MDM2 and MDM4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717202", "l": "GNAT3 exchanges GDP for GTP in L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12493", "l": "L-methionine => D-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57699", "l": "ATP + cob(I)inamide--[corrinoid adenosyltransferase] <=> adenosylcob(III)inamide + apo-[corrinoid adenosyltransferase] + triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41610", "l": "2-O-sulfo-alpha,alpha-trehalose + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + alpha,alpha-trehalose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43504", "l": "5-hydroxymethylfurfural + O2 = 2,5-diformylfuran + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30785", "l": "(R)-glycerate + 2 H(+) + NADH => D-glyceraldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874718", "l": "TTPA binds alpha-TOH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052596", "l": "phenethylamine:oxygen oxidoreductase (deaminating) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47706", "l": "cytochalasin Z16 + H2O + NADP(+) => H(+) + iso-precytochalasin + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617683", "l": "EP300,CREBBP bind SOH-C481-FOXO4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35661", "l": "GDP + H(+) + mannosylinositol phosphorylphytoceramide => an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849878", "l": "PSD-95 binds NMDA receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-164617", "l": "Elongation of Extended Telomeric Chromosome End (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66607", "l": "a 2'-deoxycytidine in double-stranded DNA + H(+) + H2O <=> a 2'-deoxyuridine in double-stranded DNA + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084912", "l": "Arresten binds integrin alpha1beta1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610752", "l": "GLI3R translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56184", "l": "globoside Gb4Cer + UDP-alpha-D-galactose = globoside NOR1 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349404", "l": "CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18685", "l": "H(+) + NADPH + O2 + pentachlorophenol = 2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62513", "l": "2-oxoglutarate + melatonin + O2 => 2-hydroxymelatonin + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950448", "l": "STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61288", "l": "5-deoxy-D-ribose + ATP = 5-deoxy-alpha-D-ribose 1-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810076", "l": "DDO oxidizes D-Asp to OA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005291", "l": "high-affinity L-histidine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956659", "l": "ABL1 phosphorylates YAP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37445", "l": "1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45636", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047603", "l": "acetoacetyl-CoA hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44383", "l": "a 3-demethylubiquinol + S-adenosyl-L-methionine <=> a ubiquinol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42925", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51230", "l": "17alpha-ethynylestradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+) => 17alpha-ethynylestradiol + 3'-phosphoadenylyl sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34749", "l": "15-methylhexadecasphinganine 1-phosphate + ADP + H(+) => 15-methylhexadecasphinganine + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426209", "l": "DAG activation of TRPC channels (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39408", "l": "3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41189", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170674", "l": "Dissociation of the Gi alpha:G olf complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9659820", "l": "RB1 translocates to the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607734", "l": "PKC-delta translocates to plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58588", "l": "dihydroprecondylocarpine acetate + NADPH = (+)-vincadifformine + acetate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1606564", "l": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606312", "l": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29980", "l": "2'-deoxyadenosine(in) + H(+)(in) => 2'-deoxyadenosine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694280", "l": "mRNA4 is translated to protein E (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27289", "l": "(S)-acetoin + NAD(+) <=> diacetyl + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43768", "l": "an alkylamine + L-glutaminyl-[protein] = N(5)-alkyl-L-glutaminyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57114", "l": "1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20546", "l": "H(+) + L-kynurenine + NADPH + O2 => 3-hydroxy-L-kynurenine + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62243", "l": "a thymidine(6-4)cytidine in DNA <=> a thymine-cytidine dinucleotide in DNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211983", "l": "CYP2J2 oxidises ARA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004905", "l": "type I interferon receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12672", "l": "H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] <=> L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446077", "l": "BP230 interacts with keretin K5/K14 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67028", "l": "(glutathione)4[2Fe(III)-2S] cluster(in) + ATP + H2O = (glutathione)4[2Fe(III)-2S] cluster(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687088", "l": "PKA phosphorylates MAPKAPK5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40530", "l": "2 a ubiquinol + 4 H(+)(in) + O2(in) <=> 2 a ubiquinone + 4 H(+)(out) + 2 H2O(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034039", "l": "8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042071", "l": "leucokinin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210290", "l": "Interaction of PECAM-1 and SHIP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688786", "l": "ATXN3 binds RAD23 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63423", "l": "2-hydroxyethylphosphonate + CTP <=> cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32408", "l": "(1R,2S,4S)-neoisodihydrocarveol + NAD(+) => (1R,4S)-isodihydrocarvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41285", "l": "sphing-4-enine + tetracosanoate => H2O + N-tetracosanoyl-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781899", "l": "USP13 binds SIAH2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-167415", "l": "G-protein alpha subunit is inactivated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395412", "l": "Phosphorylation of SYK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989764", "l": "Expression of CYP1A1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29035", "l": "ATP + H2O + L-glutamate(out) = ADP + H(+) + L-glutamate(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001071", "l": "maltoheptaose binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8858475", "l": "TNFSF9 binds TNFRSF9 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696482", "l": "CTF1 binds LIFR:JAKs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57821", "l": "[phosphate](n) + ADP => [phosphate](n+1) + AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55142", "l": "AMP + D-alanyl-[D-alanyl-carrier protein] + H(+) => D-alanyl-5'-AMP + holo-[D-alanyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029473", "l": "Branching and elongation of mother and daughter filaments (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43391", "l": "1D-myo-inositol 3,4-bisphosphate + H2O <=> 1D-myo-inositol 3-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30627", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) = (2S)-2-acetolactate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51370", "l": "CoA + H(+) + N-octadecanoylglycine => glycine + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41330", "l": "(12S)-hydroperoxy-(8Z,10E,14Z)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15075", "l": "D-glucuronate + N(2),6-disulfo-D-glucosamine => 3-D-glucuronosyl-N(2),6-disulfo-beta-D-glucosamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31514", "l": "chenodeoxycholoyl-CoA + H2O <=> chenodeoxycholate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31663", "l": "2-oxoglutarate + UDP-N-acetylbacillosamine = L-glutamate + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose"}, {"i": "EC:2.6.1.34", "l": "\"UDP-N-acetylbacillosamine transaminase\""}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015087", "l": "cobalt ion transmembrane transporter activity"}, {"i": "RHEA:28578", "l": "Co(2+)(in) = Co(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853745", "l": "RET binds GFRA1,GFRA3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38256", "l": "(S)-malate + succinyl-CoA => (S)-malyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38084", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol => 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47852", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871265", "l": "YAP1 binds TEAD4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22429", "l": "N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 => 2 H2O + isopenicillin N"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37174", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34586", "l": "2-oxoglutarate + O2 + pentalenolactone D <=> CO2 + H2O + pentalenolactone E + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70573", "l": "argininosuccinate <=> fumarate + arginine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62206", "l": "2 [Fe(II)cytochrome c] + 2 H(+) + propanal => 1-propanol + 2 [Fe(III)cytochrome c]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14486", "l": "(2E,6E)-farnesyl diphosphate + H2O => 10-epi-juneol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54035", "l": "(6S)-10-formyltetrahydrofolate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose <=> (6S)-5,6,7,8-tetrahydrofolate + dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052895", "l": "N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871193", "l": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019826", "l": "oxygen sensor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10192", "l": "ATP + H2O + sulfate(out) = ADP + H(+) + phosphate + sulfate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27506", "l": "cocaine + H2O = benzoate + ecgonine methyl ester + H(+)"}, {"i": "EC:3.1.1.84", "l": "\"Cocaine esterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10267", "l": "alpha-D-glucose <=> beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193964", "l": "CYP21A2 21-hydroxylates PROG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5688797", "l": "ATXN3 family cleave Ub chains (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1605591", "l": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25648", "l": "(2R,5R)-isomenthone + NADP(+) <=> (R)-pulegone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59920", "l": "(2E)-octenal + H2O + NAD(+) = (2E)-octenoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48759", "l": "erythritol + NAD(+) <=> D-erythrulose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51544", "l": "D-ribulose = D-xylulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390930", "l": "5-HT2 receptor can bind serotonin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14585", "l": "gibberellin A12 + 5 H(+) + 3 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = CO2 + gibberellin A9 + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685604", "l": "SLAMF6 binds SLAMF6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48395", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + GDP-beta-L-fucose <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49583", "l": "(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate <=> cyclic pyranopterin phosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003827", "l": "alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55348", "l": "all-trans-retinol = 9-cis-retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70481", "l": "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5229343", "l": "AXIN is phosphorylated in the destruction complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868118", "l": "MAPK12 phosphorylates PTPN3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51893", "l": "H2O + N-acetylcadaverine => acetate + cadaverine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0010279", "l": "indole-3-acetic acid amido synthetase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3215406", "l": "PRMT5 binds WDR77 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60860", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43735", "l": "a triacyl-sn-glycerol + H2O <=> 1,3-diacyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28856", "l": "H(+)(in) + melibiose(in) => H(+)(out) + melibiose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0005243", "l": "gap junction channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69152", "l": "Removal of remaining Flap (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43379", "l": "5'-deoxyinosine + phosphate <=> 5-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2314686", "l": "Aspirin acetylates PTGS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419255", "l": "5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + fumarate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56217", "l": "O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27799", "l": "(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate => all-trans-octaprenyl diphosphate + 5 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54516", "l": "8-hydroxycopalyl diphosphate = (13R)-manoyl oxide + diphosphate"}, {"i": "EC:4.2.3.190", "l": "\"Manoyl oxide synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65318", "l": "chrodrimanin E + CO2 + H2O + succinate => 2-oxoglutarate + chrodrimanin H + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50809", "l": "glutathione + prostaglandin J2 => prostaglandin J2-S-(S)-glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59472", "l": "2',3'-cGAMP + H2O = Gp(2'-5')Ap(3') + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19815", "l": "2-oxosuccinamate + an L-alpha-amino acid => a 2-oxocarboxylate + L-asparagine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50991", "l": "prostaglandin F2alpha(out) <=> prostaglandin F2alpha(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53711", "l": "(2E)-decenoyl-CoA + NADP(+) <=> (2E,4Z)-decadienoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13640", "l": "H(+) + methane + NADH + O2 <=> H2O + methanol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381644", "l": "ER calcium channels open in response to activated PKA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32431", "l": "(1R,4S)-menthone + H(+) + NADPH + O2 = (4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34119", "l": "3 H(+) + hexanoyl-CoA + 3 malonyl-CoA = 3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 CoA"}, {"i": "EC:2.3.1.206", "l": "\"3,5,7-trioxododecanoyl-CoA synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.100", "l": "\"(R)-amidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-688137", "l": "RIP2 is K63 polyubiquitinated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-179410", "l": "Association of Nek2A with MCC:APC/C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14483", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate => 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938887", "l": "PML binds RUNX1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663002", "l": "MT3 binds copper (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444705", "l": "T1R1/T1R3 dimer is the umami taste receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-167429", "l": "The receptor:G-protein complex  binds GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.116", "l": "\"D-arabinose 1-dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38855", "l": "2 [Fe(II)-cytochrome b5] + a 1,2-saturated fatty acid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (R)-2-hydroxy fatty acid + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50285", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 => (12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033226", "l": "2-aminoethylphosphonate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43702", "l": "methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine => (2E,6E)-farnesoate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28256", "l": "(3Z)-hex-3-en-1-yl acetate + CoA => (3Z)-hex-3-en-1-ol + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55084", "l": "(3R)-3-hydroxypentanoyl-CoA + H2O = (3R)-3-hydroxypentanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42444", "l": "L-aspartate + NADP(+) = H(+) + iminosuccinate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11108", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate = n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+)"}, {"i": "EC:2.8.2.17", "l": "\"Chondroitin 6-sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18290", "l": "(S,S)-tartrate => H2O + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25364", "l": "3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NAD(+) => H(+) + momilactone A + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65586", "l": "8-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-casbene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66437", "l": "NADP(+) + pentan-3-one => H(+) + NADPH + pent-1-en-3-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034257", "l": "nicotinamide riboside transmembrane transporter activity"}, {"i": "RHEA:33163", "l": "beta-nicotinamide D-riboside(in) = beta-nicotinamide D-riboside(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098769", "l": "TIMP family protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-422454", "l": "Polysialylation of NCAM1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53726", "l": "ADP + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate => ATP + N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31600", "l": "FMNH2 + NADH + O2 + thymine => (Z)-2-methylureidoacrylate + FMN + H(+) + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047611", "l": "acetylspermidine deacetylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55069", "l": "a 12-oxojasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] => a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11601", "l": "ATP + CMP => ADP + CDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37450", "l": "O2 + tetracenomycin F1 <=> H(+) + H2O + tetracenomycin D3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.1.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68688", "l": "CDC6 association with ORC:origin complexes mediated by MCM8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867047", "l": "PTPN3 dephosphorylates EPS15 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2990880", "l": "NEK6/NEK7 phosphorylates NUP98 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66493", "l": "GDP-alpha-D-mannose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-galctosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9663511", "l": "BIL binds GSTA1, FABP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684052", "l": "PIAS4 SUMOylates MDC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57796", "l": "4-nitrotoluene + NADH + O2 = 4-methylcatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209255", "l": "UPD ligand binds to the HOP:DOME:DOME:HOP complex and activates HOP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030752", "l": "5-hydroxyfuranocoumarin 5-O-methyltransferase activity"}, {"i": "RHEA:11808", "l": "bergaptol + S-adenosyl-L-methionine = bergapten + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043139", "l": "5'-3' DNA helicase activity"}, {"i": "REACT:R-HSA-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-374909", "l": "Metabolism of Noradrenaline (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.22", "l": "\"Coagulation factor IXa\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20266", "l": "2-oxoglutarate + L-proline + O2 => cis-3-hydroxy-L-proline + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1462039", "l": "Pro-HNP1-4 are cleaved to biologically active defensin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876472", "l": "NPC2 binds CHOL (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18804", "l": "(cis-prenyl)n-diphosphate + isopentenyl diphosphate <=> (cis-prenyl)(n+1)-diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202960", "l": "Caspase mediated cleavage of C-IAP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624130", "l": "Myristoylated NPHP3 translocates into the ciliary membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36308", "l": "(E)-caffeoyl-CoA + H2O => 3,4-dihydroxybenzaldehyde + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64070", "l": "1-phenyl-1,2-propanedione + H(+) + NADH => (R)-phenylacetylcarbinol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097016", "l": "L27 domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158860", "l": "SULT1A1 dimer sulfonates NHABP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60106", "l": "(E)-3-(indol-3-yl)acrylate + reduced [electron-transfer flavoprotein] => 3-(1H-indol-3-yl)propanoate + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004969", "l": "histamine receptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0022824", "l": "transmitter-gated ion channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11591", "l": "A + H2O + isoquinoline <=> AH2 + isoquinolin-1(2H)-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21606", "l": "2-phenylacetaldehyde => styrene oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34492", "l": "H2O + UDP-N,N'-diacetylbacillosamine => 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37435", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphate = a 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953013", "l": "E2F7 binds E2F8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56262", "l": "4 H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP => N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190263", "l": "FGFR3b binds to FGF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683478", "l": "CQ, HCQ diffuses from cytosol to endocytic vesicle lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6813749", "l": "ALDH1A1 oxidises GA to DGA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35813", "l": "(-)-medicarpin + H2O => (3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13379", "l": "ADP + alpha-D-glucose 1,6-bisphosphate + H(+) => alpha-D-glucose 1-phosphate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42777", "l": "adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59166", "l": "AMP + diphosphate + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] => ATP + hexadecanoate + holo-[(hydroxy)phthioceranic acid synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51202", "l": "H2O + N-retinylidene-N-retinylphosphatidylethanolamine => a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-retinylidene-N-retinylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482629", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9671145", "l": "DKC1 binds SHQ1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5218805", "l": "PKC autophosphorylates (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211206", "l": "Translocation of DFF to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52503", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (13R)-hydroxy-(9Z,11E)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37552", "l": "3-dehydro-D-glucose 6-phosphate + L-glutamate => 2-oxoglutarate + D-kanosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42771", "l": "a (2S)-2-hydroxycarboxylate + NADP(+) <=> a 2-oxocarboxylate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32525", "l": "beta-D-glucose 1-phosphate + D-glucose => nigerose + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047448", "l": "5-dehydro-4-deoxyglucarate dehydratase activity"}, {"i": "MetaCyc:4.2.1.41-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507875", "l": "Aquaporins passively transport urea into cells (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12504", "l": "NAD(+) + thiomorpholine-3-carboxylate = 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5631941", "l": "SESN1,2,3 bind AMPK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44251", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110307", "l": "REV1 binds AP-dsDNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0120015", "l": "sterol transfer activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25714", "l": "L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64363", "l": "(3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 <=> (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50546", "l": "prostaglandin B2 => prostaglandin C2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613666", "l": "p-PLINs translocate from lipid droplet surface to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694390", "l": "nsp15 binds RB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35185", "l": "4-carboxy-2-thioxobutanoyl-CoA => 5-hydroxythiophene-2-carbonyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11131", "l": "4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58312", "l": "25-substituted-cholesteryl beta-D-glucoside + H2O = 25-substituted-cholesterol + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874195", "l": "MBTPS2 (S2P) cleaves CREB3L4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41358", "l": "geranylgeranyl-bacteriochlorophyllide a + 3 H(+) + 3 NADPH => bacteriochlorophyll a + 3 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64420", "l": "H(+)(out) + L-alanyl-L-proline(out) = H(+)(in) + L-alanyl-L-proline(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218822", "l": "CRK binds BCAR1 and or PXN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53795", "l": "benzylthiol + O2 <=> benzothialdehyde + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62998", "l": "(8Z,11Z,14Z)-eicosatrienoate + NH4(+) => (8Z,11Z,14Z)-eicosatrienamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055104", "l": "ligase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49762", "l": "ethylenediaminetriacetate + FMN + glyoxylate + 2 H(+) + H2O => EDTA + FMNH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244415", "l": "botA HC:LC binds SV2A, B, or C and GT1b on the target cell surface (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44826", "l": "a 1,2-diacylglycerol + a monoacyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654625", "l": "Activated FGFR3 binds SHC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937807", "l": "SRC phosphorylates RUNX3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687724", "l": "GSK3B binds GSKi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62329", "l": "(+)-isomalbrancheamide B + chloride + FAD + 2 H(+) => (+)-malbrancheamide + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429036", "l": "SLC2A9 transports Fru, Glc, urate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015344", "l": "siderophore uptake transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57117", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22702", "l": "gibberellin A12 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => gibberellin A12 aldehyde + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17839", "l": "2-carboxy-D-arabinitol + phosphate => 2-carboxy-D-arabinitol 1-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798624", "l": "ZNF420 binds TP53AIP1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20050", "l": "1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O => 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-915148", "l": "Correctly folded glycoproteins translocate to the Golgi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214891", "l": "Full-length GD is cleaved by an unknown protease (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13064", "l": "O2 + S-sulfanylglutathione <=> glutathione S,S-dioxide + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982775", "l": "Growth hormone receptor dimerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.1", "l": "\"Chymotrypsin\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047208", "l": "o-dihydroxycoumarin 7-O-glucosyltransferase activity"}, {"i": "RHEA:14325", "l": "7,8-dihydroxycoumarin + UDP-alpha-D-glucose = daphnin + H(+) + UDP"}, {"i": "EC:2.4.1.104", "l": "\"o-dihydroxycoumarin 7-O-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11574", "l": "chenodeoxycholate + FADH2 => FAD + H(+) + H2O + lithocholate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102948", "l": "luteolin C-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-9081"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483212", "l": "PS is decarboxylated to PE by PISD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40705", "l": "1-O-(9Z,12Z)-octadecadienylglycerone 3-phosphate + H(+) + hexadecanoate => (9Z,12Z)-octadecadien-1-ol + 1-hexadecanoylglycerone 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199935", "l": "MSK1 activates CREB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58267", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol <=> an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25115", "l": "H2O + pyridoxine 5'-phosphate <=> phosphate + pyridoxine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048257", "l": "3'-flap endonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033485", "l": "Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209891", "l": "Dopamine is oxidised to noradrenaline (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690785", "l": "BAP1 binds Ub-HCFC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044016", "l": "histone acetyltransferase activity (H3-K4 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607738", "l": "SYK binds p-Y15-CLEC7A:1,3-beta-D-glucan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12339", "l": "carboxymethoxysuccinate <=> fumarate + glycolate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429157", "l": "ABCC4 accumulation of dense granule contents (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141159", "l": "TNF-mediated dimerization of procaspase-8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372843", "l": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63425", "l": "(2S)-2-phospholactate + GTP + H(+) => (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75079", "l": "Formation of AT-AC C complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19377", "l": "NADP(+) + reduced riboflavin = 2 H(+) + NADPH + riboflavin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264615", "l": "Loading of acetylcholine in synaptic vesicles (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31614", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene <=> H2O + rhodopin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59609", "l": "beta-alanyl-L-lysine + H2O => beta-alanine + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69127", "l": "Formation of the Flap Intermediate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.162", "l": "\"Lambda-carrageenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66515", "l": "1-acyl-2-(9Z,12Z-octadecadienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786034", "l": "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954117", "l": "E2F6:TFDP1 binds EPC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59716", "l": "D-maltopentaono-1,5-lactone + H2O = D-maltopentaonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.2.1.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26461", "l": "ethylnitronate + FMNH2 + O2 <=> acetaldehyde + FMN + 2 H(+) + H2O + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22905", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] => gibberellin A12 aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8873946", "l": "OTUD3 deubiquitinates PTEN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0016696", "l": "oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor"}, {"i": "EC:1.12.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55168", "l": "[TtuB sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) = [TtuB sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033758", "l": "clavaminate synthase activity"}, {"i": "MetaCyc:1.14.11.21-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50150", "l": "a fatty acid + ethanol + H(+) => a fatty acid ethyl ester + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41289", "l": "sphing-4-enine + tetradecanoate => H2O + N-tetradecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.59", "l": "\"Caspase-6\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32485", "l": "CO2 + methanol + pyropheophorbide a => H(+) + H2O + pheophorbide a"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047786", "l": "cortisone alpha-reductase activity"}, {"i": "MetaCyc:CORTISONE-ALPHA-REDUCTASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873919", "l": "Phosphorylation of JAK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204600", "l": "Basigin homodimerises (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156682", "l": "PLK1 phosphorylates NUDC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14561", "l": "(E,E)-piperoyl-CoA + piperidine = CoA + H(+) + N-[(E,E)-piperoyl]piperidine"}, {"i": "EC:2.3.1.145", "l": "\"Piperidine N-piperoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72185", "l": "mRNA polyadenylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56269", "l": "CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => CMP + H(+) + N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63726", "l": "candesartan O-beta-D-glucuronoside + UDP => candesartan + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39665", "l": "a quinone + reduced coenzyme F420-(gamma-Glu)(n) => a quinol + H(+) + oxidized coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51788", "l": "2-hydroxybenzoyl-5'-AMP + CoA = 2-hydroxybenzoyl-CoA + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0015116", "l": "sulfate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388811", "l": "CD28 homodimer binds B7-1 homodimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53527", "l": "1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9668335", "l": "CHMP7 binds LEMD2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51434", "l": "[(1S)-1-acetamidoethyl]phosphonate + CoA => (S)-1-aminoethylphosphonate + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.6", "l": "\"Carboxylate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18147", "l": "ADP + beta-D-fructose 1-phosphate + H(+) => ATP + beta-D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48843", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139905", "l": "Translocation of activated BAD protein to mitochondria (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12587", "l": "16alpha-hydroxyprogesterone <=> 16,17-didehydroprogesterone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37009", "l": "3-oxo-(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + CO2 + CoA => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.n5"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072552", "l": "monoferuloyl di-(hydroxyferuloyl) spermidine meta-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57856", "l": "(E)-feruloyl-CoA + 2-oxoglutarate + O2 = (E)-6-hydroxyferuloyl-CoA + CO2 + succinate"}, {"i": "EC:1.14.11.61", "l": "\"Feruloyl-CoA 6-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56021", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2) => beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948034", "l": "FGR binds LDL:LRP8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130349", "l": "Generation of CLIP from lip10 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-164840", "l": "ADP and Pi bind to ATPase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018746", "l": "RHOQ binds effectors at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54565", "l": "5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O => a 5'-phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62268", "l": "(R)-2-hydroxy-3-methylbutyrate + NADP(+) = 3-methyl-2-oxobutanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34834", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate <=> N-acyl-15-methylhexadecasphing-4-enine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45695", "l": "N-(octanoyl)-sphing-4-enine-1-phosphate(in) <=> N-(octanoyl)-sphing-4-enine-1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43331", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977228", "l": "Sialyltransferase I can add sialic acid to the T antigen at the alpha 6 position (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9645220", "l": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450187", "l": "TAK1 is activated within the TAK1 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21597", "l": "L-serine + NADP(+) => 2-aminomalonate semialdehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49722", "l": "CO2 + 2 H2O + NAD(+) + violacein => 2 H(+) + NADH + 2 O2 + protoviolaceinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-881988", "l": "CRY is phosphorylated by SGG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36030", "l": "CoA + NAD(+) + propanal <=> H(+) + NADH + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45757", "l": "(6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2 => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32020", "l": "(2E,6E)-farnesyl diphosphate => beta-cubebene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694428", "l": "LMAN family proteins bind glycosylated cargo (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61230", "l": "3-(imidazol-5-yl)pyruvate + H2O2 + NH4(+) => H2O + L-histidine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47707", "l": "H(+) + iso-precytochalasin + NADPH + O2 <=> cytochalasin Z16 + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140463", "l": "chromatin-protein adaptor"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14044", "l": "(R)-vicianin + H2O <=> mandelonitrile + vicianose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45938", "l": "4-hydroxy-6-(4-methyl-2-oxododecyl)pyran-2-one + 3 CO2 + 4 CoA => 3-methylundecanoyl-CoA + 3 H(+) + 3 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43123", "l": "2-oxoglutarate + O2 + xanthine <=> CO2 + succinate + urate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1912369", "l": "NOTCH precursor cleaved to form mature NOTCH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-844438", "l": "NLRP1 oligomerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52678", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine => [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56320", "l": "a 5-hydroxy anthocyanidin + UDP-alpha-D-glucose = an anthocyanin 5-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427570", "l": "Group 3 - Selective Cl- transport (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43215", "l": "adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417114", "l": "Assembly of telomerase RNP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-481007", "l": "Exocytosis of platelet alpha granule contents (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16313", "l": "5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+)"}, {"i": "EC:3.1.1.66", "l": "\"5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39347", "l": "(2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADPH = (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58190", "l": "dihydroisopentenyldehydrorhodopin + diphosphate => all-trans-lycopene + dimethylallyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44169", "l": "dodecanoate + 2 H(+) + NADH => dodecanal + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939852", "l": "RUNX2 and SP7 bind the UCMA gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981892", "l": "Active G alpha (z) binds RGS proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853792", "l": "RET tyrosine phosphorylation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60636", "l": "N-(dodecanoyl)-sphing-4-enine-1-phosphocholine = choline + N-dodecanoyl-sphing-4-enine-1,3-cyclic phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39913", "l": "(3S)-2-oxo-3-phenylbutanoate + L-glutamate => (2S,3S)-3-methylphenylalanine + 2-oxoglutarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047937", "l": "glucose-1-phosphate phosphodismutase activity"}, {"i": "RHEA:16397", "l": "2 D-glucopyranose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate"}, {"i": "EC:2.7.1.41", "l": "\"Glucose-1-phosphate phosphodismutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39336", "l": "3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9679775", "l": "COMT binds COMT Inhibitors (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52062", "l": "(9Z)-octadecenoate + 12-hydroxyoctadecanoate + H(+) => 12-(9Z-octadecenoyloxy)-octadecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24753", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + primary fluorescent chlorophyll catabolite => 3 H(+) + red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10881", "l": "7-methylxanthosine + H2O => 7-methylxanthine + D-ribose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015208", "l": "guanine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30638", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate <=> alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9674095", "l": "PDGFRs bind type II TKI (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19735", "l": "bacteriochlorophyllide a + H(+) + NADH => 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374916", "l": "Re-acidification of clathrin sculpted monoamine transport vesicle lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43993", "l": "(2E,6E,10E)-geranylgeraniol + H(+) + NADPH + O2 => 16-hydroxy-(2E,6E,10E)-geranylgeraniol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30854", "l": "beta-D-fructose 1-phosphate <=> D-glyceraldehyde + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10700", "l": "H2O + limonene 1,2-epoxide = limonene-1,2-diol"}, {"i": "EC:3.3.2.8", "l": "\"Limonene-1,2-epoxide hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984821", "l": "Kinesin-12 is a dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65175", "l": "(3Z,5E)-dodecadienoyl-CoA + H2O <=> (3Z,5E)-dodecadienoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295613", "l": "SPRY2 binds GRB2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12907", "l": "GDP-alpha-D-mannose + phosphate => alpha-D-mannose 1-phosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13849", "l": "D-arabinose = D-ribulose"}, {"i": "EC:5.3.1.3", "l": "\"D-arabinose isomerase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098808", "l": "mRNA cap binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451377", "l": "Interaction of IQGAP1 with nephrin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709852", "l": "MAVS:TOMM70 recruits HSP90:TBK1:IRF3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43164", "l": "7-cyano-7-deazaguanine + guanosine(15) in tRNA = 7-cyano-7-carbaguanosine(15) in tRNA + guanine"}, {"i": "EC:2.4.2.48", "l": "\"tRNA-guanine(15) transglycosylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58339", "l": "a 4-hydroxynonen-1-ol + NADP(+) <=> a 4-hydroxynonenal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0003909", "l": "DNA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38544", "l": "H(+) + malonyl-CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein] => (2-aminobenzoyl)acetyl-CoA + CO2 + L-cysteinyl-[PqsD protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39041", "l": "a dicarboxylate + 2 H(+) + NADH => an omega-oxo fatty acid + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20250", "l": "L-alanine => D-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70481", "l": "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036427", "l": "all-trans-undecaprenyl-phosphate mannosyltransferase activity"}, {"i": "RHEA:28118", "l": "di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693593", "l": "D-loop extension by DNA polymerases (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41866", "l": "decanoyl-[ACP] + NADP(+) => (2E)-decenoyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196753", "l": "2xPPCS ligates PPanK with Cys (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43537", "l": "2 D-glyceraldehyde 3-phosphate => 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209536", "l": "IkB is ubiquitinated and degraded (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15979", "l": "4-hydroxybenzaldehyde + hydrogen cyanide => (S)-4-hydroxymandelonitrile"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669012", "l": "EDA binds EDAR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811479", "l": "ING2 recruits EP300 to TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814695", "l": "PERP binds desmosomes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-351207", "l": "Spermine  => N-acetylated spermine (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45112", "l": "gamma-tocopherol + H(+) + NADPH + O2 = 13-hydroxy-gamma-tocopherol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879562", "l": "SLCO2B1 has a narrow substrate specificity (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47605", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) => CMP + ganglioside GP1calpha (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102081", "l": "homotaurine:2-oxoglutarate aminotransferase activity"}, {"i": "MetaCyc:RXN-10822"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12012", "l": "ATP + thiamine = ADP + H(+) + thiamine phosphate"}, {"i": "EC:2.7.1.89", "l": "\"Thiamine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708557", "l": "FBXL17 binds BACH1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2172123", "l": "Interaction of SIGLEC14/15/16 and DAP12 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008941", "l": "nitric oxide dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429441", "l": "SYK activation by SRC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-481010", "l": "Surface deployment of platelet dense granule membrane components (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33062", "l": "(R)-dihydrolipoamide + NAD(+) <=> (R)-lipoamide + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001147", "l": "transcription termination site sequence-specific DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65534", "l": "2-methylbutyl hexanoate + CoA => 2-methylbutan-1-ol + hexanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374701", "l": "Phosphorylation of DCC by Fyn (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051264", "l": "mono-olein transacylation activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9669854", "l": "KIT binds type II TKIs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29128", "l": "a menaquinol + nitrate => a menaquinone + H2O + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31239", "l": "4 H(+) + uroporphyrinogen I = 4 CO2 + coproporphyrinogen I"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687284", "l": "DMBT1 binds SFTPD 12mer, SFTPAs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376122", "l": "DSCAM/DSCAML1 homodimerization (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1564169", "l": "Collagen type VIII degradation by MMP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000825", "l": "inositol tetrakisphosphate 6-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41475", "l": "ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oryzalexin D + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035034", "l": "histone acetyltransferase regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989756", "l": "Expression of ME1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202453", "l": "Auto-ubiquitination of TRAF6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48654", "l": "20-hydroxy-lipoxin B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lipoxin B4 + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63769", "l": "2 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450494", "l": "HuR binds mRNAs in the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862280", "l": "FCHo proteins bind nascent clathrin-coated pit (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9615249", "l": "ARBs bind AGRT1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210274", "l": "SIRP beta binds TYROBP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218824", "l": "p-6Y-VEGFR2 binds FYN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57227", "l": "glyoxal + GTP <=> N(2)-(1-hydroxy-2-oxoethyl)-GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34827", "l": "H(+) + N-acyl-15-methylhexadecasphinganine + NADPH + O2 = H2O + N-acyl-4-hydroxy-15-methylhexadecasphinganine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11633", "l": "AH2 + L-selenocysteine => A + H(+) + hydrogenselenide + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429767", "l": "Passive I- efflux mediated by SMCT1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37494", "l": "4-coumaroyl-CoA + S-adenosyl-L-methionine <=> CoA + H(+) + N-(4-coumaroyl)-L-homoserine lactone + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003825", "l": "alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44727", "l": "2,3-saturated fatty aldehyde + NADP(+) <=> (2E)-fatty aldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64071", "l": "(R)-phenylacetylcarbinol + NAD(+) <=> 1-phenyl-1,2-propanedione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607023", "l": "factor IXa associates with cell membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665761", "l": "FMNL3 binds RHOC:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30566", "l": "dimethylallyl diphosphate + L-tryptophan <=> 7-(3-methylbut-2-enyl)-L-tryptophan + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5669158", "l": "NF2 binds PAK1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203979", "l": "Coat Assembly (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-874087", "l": "SGT1 binds HSP90 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15301", "l": "D-apiitol + NAD(+) = aldehydo-D-apiose + H(+) + NADH"}, {"i": "EC:1.1.1.114", "l": "\"Apiose 1-reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938217", "l": "RUNX1 binds the SWI/SNF complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32971", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + 2 H2O = 2 a carboxylate + 2 H(+) + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805981", "l": "HMGB1 release from cells (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605717", "l": "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004303", "l": "estradiol 17-beta-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1299359", "l": "Activation of TALK (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19604", "l": "H(+) + NADH + O2 + orcinol <=> 2,3,5-trihydroxytoluene + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58593", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16903", "l": "(2S)-4-acetamido-2-aminobutanoate + CoA + H(+) => acetyl-CoA + L-2,4-diaminobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23357", "l": "ATP + L-seryl-[rhodopsin] => ADP + H(+) + O-phospho-L-seryl-[rhodopsin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50305", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] => 21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693125", "l": "RHOF binds effectors at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2317314", "l": "AKT binds PDPK1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40837", "l": "2 (9Z)-octadecenoate + 2 H(+) + sn-glycerol 3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5683792", "l": "p-T68-CHEK2 autophosphorylates (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264622", "l": "Cho is acetylated to AcCho by CHAT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956608", "l": "MYB gene transcription is stimulated by the RUNX1-containing TAL1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102659", "l": "UDP-glucose: 4-methylthiobutylhydroximate S-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602892", "l": "Defective GCLC does not ligate L-Glu to L-Cys (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392513", "l": "Rap1 signal termination by Rap1GAPs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15550", "l": "S-methyl-5-thio-D-ribulose 1-phosphate => 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805640", "l": "AKT phosphorylates KAT6A (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30267", "l": "2 monodehydro-L-ascorbate radical = L-ascorbate + L-dehydroascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019771", "l": "high-affinity IgG receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12355", "l": "L-gulono-1,4-lactone + O2 <=> H2O2 + L-xylo-hex-3-ulonolactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41484", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62331", "l": "(+)-isomalbrancheamide B + chloride + FAD + 2 H(+) <=> (+)-malbrancheamide + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31574", "l": "1-hydroxy-2-naphthoate + 2 H(+) + NADPH + O2 <=> CO2 + H2O + NADP(+) + naphthalene-1,2-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.54"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2167942", "l": "Collagen type XIII ectodomain shedding (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110215", "l": "Cleavage of uracil by UNG glycosylase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52312", "l": "NAD(+) + thromboxane B2 = 11-dehydro-thromboxane B2 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50823", "l": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) <=> H(+) + NADPH + testosterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16117", "l": "acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate"}, {"i": "EC:6.2.1.16", "l": "\"Acetoacetate--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13555", "l": "ADP + alpha-D-galactose 1-phosphate + H(+) => alpha-D-galactose + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-179421", "l": "Degradation of multiubiquitinated Nek2A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61326", "l": "3beta-hydroxycostunolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51704", "l": "S-adenosyl-L-methionine + xanthohumol = 4-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.339", "l": "\"Xanthohumol 4-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43724", "l": "(2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.128", "l": "\"Farnesoate epoxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32670", "l": "coenzyme M + methanethiol <=> H(+) + hydrogen sulfide + methyl-coenzyme M"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009034", "l": "tryptophanase activity"}, {"i": "KEGG.REACTION:R00673"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141139", "l": "Trimerization of TRAIL:TRAIL receptor complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42254", "l": "3-oxoheptanoyl-[ACP] + CO2 + CoA => H(+) + malonyl-[ACP] + pentanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47700", "l": "H(+) + ketocytochalasin + NADPH + O2 = H2O + iso-precytochalasin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605717", "l": "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58137", "l": "acetate + ATP + H(+) => acetyl-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29192", "l": "L-aspartate + menaquinone-8 => iminosuccinate + menaquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12219", "l": "9H-fluoren-9-ol + NAD(+) <=> 9H-fluoren-9-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5684140", "l": "ATM phosphorylates RBBP8 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607753", "l": "CARD9 oligomerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635839", "l": "ULK3:SUFU dissociates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005138", "l": "interleukin-6 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8934742", "l": "RUNX1 binds PRMT1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33846", "l": "H2O + N-tetracosanoylsphinganine <=> sphinganine + tetracosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35709", "l": "(3S)-versiconol acetate + H2O + NADP(+) => (2S)-versicolorone + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295599", "l": "SPRY2 translocates to the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014449", "l": "RHOG binds effectors at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47446", "l": "(5Z)-tetradecenoyl-CoA + acetyl-CoA => 3-oxo-(7Z-hexadecenoyl)-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018465", "l": "vanillyl-alcohol oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429036", "l": "SLC2A9 transports Fru, Glc, urate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5685230", "l": "CHEK1 phosphorylates RAD51 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38972", "l": "O2 + octadecanoyl-CoA => (2E)-octadecenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047206", "l": "UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase activity"}, {"i": "MetaCyc:2.3.2.10-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199456", "l": "PTEN dephosphorylates PIP3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071987", "l": "WD40-repeat domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938981", "l": "IL3 gene transcription is stimulated by RUNX1 and ELF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23729", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 => A + H2O + prostaglandin H2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64163", "l": "ATP + glycyl-[methyl-coenzyme M reductase] + hydrogen sulfide <=> ADP + phosphate + thioglycyl-[methyl-coenzyme M reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25337", "l": "H2O + L-cysteinyl-tRNA(Cys) <=> H(+) + L-cysteine + tRNA(Cys)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8986083", "l": "USP33 deubiquitinates ROBO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47048", "l": "a quinone + shikimate = 3-dehydroshikimate + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54659", "l": "linalool <=> (2E)-geraniol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176318", "l": "Loading of claspin onto DNA during replication origin firing (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202222", "l": "Phosphorylation of PKC theta (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693198", "l": "RHOD binds effectors at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59522", "l": "(2S)-ethylmalonyl-CoA + ADP + H(+) + phosphate => ATP + butanoyl-CoA + hydrogencarbonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43928", "l": "pregn-5-ene-3,20-dione = progesterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61781", "l": "keto-L-tagatose => keto-L-sorbose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48122", "l": "ganglioside GM3 + N-acetylneuraminate => ganglioside GD3 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617881", "l": "HOXB4 mRNA is translated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2681694", "l": "TNC binds Syndecan-3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64757", "l": "H2O + S-benzyl-L-cysteine => benzylthiol + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36364", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 H(+) + 2 NADPH => (9Z,12Z)-octadecadien-1-ol + CoA + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59951", "l": "H2O + prostaglandin F2alpha-CoA <=> CoA + H(+) + prostaglandin F2alpha"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4837364", "l": "Secretion of SOD3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52096", "l": "9-octadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62447", "l": "L-canavanine + L-ornithine <=> H(+) + L-arginine + L-canaline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57185", "l": "L-cysteinyl-[protein] + methylglyoxal => S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10035", "l": "[protein]-C-terminal-L-glutamine + H2O <=> [protein]-C-terminal-L-glutamate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57378", "l": "(S)-1-hydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66442", "l": "but-3-en-2-one + H(+) + NADPH => butan-2-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29194", "l": "L-aspartate + menaquinone-8 <=> iminosuccinate + menaquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51268", "l": "norbelladine + S-adenosyl-L-methionine = 4'-O-methylnorbelladine + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.336", "l": "\"Norbelladine O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186785", "l": "PDGF-AA clevage by Furin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21602", "l": "CoA + N-benzoylanthranilate => anthranilate + benzoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975040", "l": "KRAB-ZNF / KAP Interaction (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5444516", "l": "Formation of MSH2:MSH6 Complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18316", "l": "(R)-mandelonitrile <=> benzaldehyde + hydrogen cyanide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130706", "l": "MHC class II antigen processing (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25654", "l": "(2S)-2-amino-3-oxobutanoate + H(+) => aminoacetone + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352914", "l": "glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44521", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17961", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = H2O + leukotriene A4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65501", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + AH2 + S-adenosyl-L-methionine => 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + A + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014433", "l": "RHOG GEFs activate RHOG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10347", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64271", "l": "emodin anthrone + O2 <=> emodin + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.n3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57860", "l": "(E)-6-hydroxyferuloyl-CoA = CoA + scopoletin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28209", "l": "2'-deoxyuridine + ATP <=> ADP + dUMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38740", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42405", "l": "H2O + lactose 6-phosphate => beta-D-glucose + D-galactose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36100", "l": "benzoate + S-adenosyl-L-methionine => methyl benzoate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29933", "l": "ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41495", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53000", "l": "17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D-glucuronate = 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32931", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2-diacyl-sn-glycerol = a cardiolipin + CMP + H(+)"}, {"i": "EC:2.7.8.41", "l": "\"Cardiolipin synthase (CMP-forming)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102883", "l": "(+)-beta-chamigrene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848338", "l": "PNPLA4 hydrolyzes TAG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964471", "l": "DREAM complex binds the CDC25A gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39011", "l": "a triacyl-sn-glycerol(in) = a triacyl-sn-glycerol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9656244", "l": "DRD2 binds DA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14710", "l": "a 3-oxo-Delta(5)-steroid => a 3-oxo-Delta(4)-steroid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53264", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 2beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21706", "l": "NH4(+) + phenol + pyruvate => H2O + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34531", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose = CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose + H(+)"}, {"i": "EC:2.3.1.209", "l": "\"dTDP-4-amino-4,6-dideoxy-D-glucose acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549385", "l": "CRY:PER:Kinase complex translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58393", "l": "4-amino-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454239", "l": "Phosphorylation of SYK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202459", "l": "Phosphorylation of Bcl10 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453339", "l": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38497", "l": "a 1,3-diacylglycerol + a fatty acid + H(+) => a triacylglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42179", "l": "(9Z)-tetradecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-tetradecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33747", "l": "a 1-acyl-sn-glycerol + ATP = a 1-acyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176116", "l": "Recruitment and activation of Chk1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033829", "l": "O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity"}, {"i": "REACT:R-HSA-5096538", "l": "Defective LFNG does not transfer GlcNAc to Pre-NOTCH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14572", "l": "propane-1,2-diol <=> H2O + propanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662614", "l": "MT1E binds zinc (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050150", "l": "o-pyrocatechuate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54424", "l": "L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710294", "l": "GSDMD expression mediated by IRF2, IRF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16768", "l": "D-mannitol + NADP(+) <=> D-fructose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0005222", "l": "intracellular cAMP-activated cation channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59236", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + isoelisabethatriene"}, {"i": "EC:4.2.3.203", "l": "\"Isoelisabethatriene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69127", "l": "Formation of the Flap Intermediate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950778", "l": "p-Y693-STAT4 dimerizes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972964", "l": "POU5F1 (OCT4), SOX2, NANOG bind the FOXD3 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63100", "l": "H(+) + ilicicolin C + NADPH + O2 = ascochlorin + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14073", "l": "3-hydroxy-L-glutamate + H(+) = 4-amino-3-hydroxybutanoate + CO2"}, {"i": "EC:4.1.1.16", "l": "\"Hydroxyglutamate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20007", "l": "an alcohol + D-glucuronate => an alpha-D-glucuronoside + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52507", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 9(R)-hydroxy-(10E,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62648", "l": "(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33141", "l": "L-alanine(in) + L-aspartate(out) => L-alanine(out) + L-aspartate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22946", "l": "5beta-pregnan-3,20-dione + H(+) + NADPH => 3beta-hydroxy-5beta-pregnane-20-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061809", "l": "NAD+ nucleotidase, cyclic ADP-ribose generating"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38322", "l": "chorismate + H2O <=> (3R,4R)-3,4-dihydroxy-3,4-dihydrobenzoate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676133", "l": "CD74 binds MIF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.37"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102772", "l": "sphingolipid long-chain base 4-hydroxylase activity"}, {"i": "MetaCyc:RXN-7797"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-901047", "l": "Binding of ERp57 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174202", "l": "Degradation of multiubiquitinated Securin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201717", "l": "CSNK2-mediated phosphorylation of DVL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40246", "l": "(3R)-hydroxyhexadecanoyl-CoA + NAD(+) <=> 3-oxohexadecanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928631", "l": "GIT1 binds bPIX (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56516", "l": "Fe-coproporphyrin III + 2 H(+) + 2 H2O2 = 2 CO2 + 4 H2O + heme b"}, {"i": "EC:1.3.98.5", "l": "\"Hydrogen peroxide-dependent heme synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38586", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22195", "l": "(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide <=> (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50049", "l": "ATP + cholate(in) + H2O => ADP + cholate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53730", "l": "N-acetyl-D-muramate + phosphate => H2O + N-acetyl-D-muramate 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944218", "l": "Association of procollagen type VIII (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874082", "l": "MET phosphorylates PTK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28145", "l": "H2O + streptothricin D <=> streptothricin D acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40319", "l": "O2 + tetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389862", "l": "Conversion of glyoxylate to oxalate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42756", "l": "cytidine(1407) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1407) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.178", "l": "\"16S rRNA (cytosine(1407)-C(5))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32468", "l": "2 S-adenosyl-L-methionine + sarcosine => glycine betaine + 2 H(+) + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24803", "l": "(S)-3-methyl-2-oxopentanoate + L-glutamate => 2-oxoglutarate + L-isoleucine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004781", "l": "sulfate adenylyltransferase (ATP) activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052611", "l": "beta-carotene 3-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11944", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + 2 H2O = 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + 2 chloride + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33809", "l": "2-methoxy-4-vinylphenol + CO2 => (E)-ferulate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61193", "l": "(E)-4-coumaroyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] => CoA + H(+) + myricetin 3-O-[(6-O-(E)-4-coumaroyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53458", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z-octadecenoate) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34546", "l": "N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine <=> H(+) + N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1237119", "l": "Acireductone is oxidized to MOB (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54640", "l": "(+)-copalyl diphosphate = (12E)-labda-8(17),12,14-triene + diphosphate"}, {"i": "EC:4.2.3.193", "l": "\"(12E)-labda-8(17),12,14-triene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21949", "l": "formamide + H2O => formate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1222491", "l": "Lactoferrin scavenges iron ions (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14925", "l": "D-mannitol 1-phosphate + NADP(+) = D-mannose 6-phosphate + H(+) + NADPH"}, {"i": "EC:1.1.1.224", "l": "\"Mannose-6-phosphate 6-reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390425", "l": "FAR1 reduces PalmCoA to HXOL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390846", "l": "D2D3,4 bind to DA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928578", "l": "EPH receptors autophosphorylate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55804", "l": "(R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'-(9Z-octadecenoyl)-3'-sn-glycerol) + H2O = (9Z)-octadecenoate + (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-sn-glycerol) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10640", "l": "muconolactone = cis,cis-muconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39221", "l": "(3R)-hydroxyoctacosanoyl-CoA + NADP(+) => 3-oxooctacosanyol-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28240", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + pseudobaptigenin => calycosin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53294", "l": "H(+) + N-carbamoyl-L-methionine => H2O + L-5-[2-(methysulfanyl)ethyl]hydantoin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19898", "l": "H(+) + 2 L-arginine + 3 NADPH + 4 O2 => 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61128", "l": "O2 + quercetin + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + myricetin + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187506", "l": "Translocation of p27 to the nucleoplasm (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202478", "l": "Interaction and oligomerization of MALT1 to Bcl10 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015347", "l": "sodium-independent organic anion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29175", "l": "2 O2 + ubiquinol-8 = 2 H(+) + 2 superoxide + ubiquinone-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39503", "l": "(2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH = (13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19214", "l": "acetyl-CoA + an S-substituted L-cysteine => an N-acetyl-L-cysteine-S-conjugate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11931", "l": "hydroxylamine + NH4(+) <=> H(+) + H2O + hydrazine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031724", "l": "CXCR5 chemokine receptor binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035539", "l": "8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13264", "l": "2-methylbutanoyl-CoA + A <=> 2-methylbut-2-enoyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983152", "l": "Transfer of ubiquitin from E1 to E2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0097642", "l": "calcitonin family receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5688834", "l": "ATXN3 binds VCP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714481", "l": "RAC2 binds effectors at the ER membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63612", "l": "prunetin + UDP-alpha-D-glucuronate = prunetin-5-O-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050266", "l": "rosmarinate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199112", "l": "CRTAM binds to NECL2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65897", "l": "glyoxylate + L-kynurenine => glycine + H2O + kynurenate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047405", "l": "pyrimidine-5'-nucleotide nucleosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802914", "l": "RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32809", "l": "thiosulfate(out) => thiosulfate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618107", "l": "ATP binding to HSP90 triggers conformation change (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42134", "l": "nocardicin C => isonocardicin C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54560", "l": "an adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + GTP = a 5'-triphospho-guanosine-ribonucleotide-tRNA(His) + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604732", "l": "Autocatalytic activation of proMMP13 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29494", "l": "(2E,6E)-farnesyl diphosphate <=> cis-muurola-4(14),5-diene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40004", "l": "ent-copalyl diphosphate => (Z)-biformene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604387", "l": "p-4S-NICD4 binds YWHAZ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34932", "l": "glutathioselenol + NADPH => glutathione + hydrogenselenide + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237119", "l": "Acireductone is oxidized to MOB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65798", "l": "1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => fenuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58156", "l": "ATP + H2O + 4 Na(+)(in) = ADP + H(+) + 4 Na(+)(out) + phosphate"}, {"i": "EC:7.2.2.1", "l": "\"Na(+)-transporting two-sector ATPase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936851", "l": "AHRR binds ARNT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031702", "l": "type 1 angiotensin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008684", "l": "TBK1 phosphorylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34551", "l": "ATP + cob(II)yrinate c monoamide + H2O + L-glutamine = ADP + cob(II)yrinate a,c diamide + H(+) + L-glutamate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678998", "l": "Endosomal TLRs pass through the Golgi (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391936", "l": "EP1 receptor can bind PGE2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27423", "l": "(3E,6E)-alpha-farnesene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83788", "l": "Binding of TFIIIC to Type 2 promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.98.1.-", "l": "\"Other oxidoreductases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3095889", "l": "MMACHC reduces Cbl (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1483089", "l": "PE is converted to PS by PTDSS2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672980", "l": "Dissociation of RAS:RAF complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28082", "l": "(2S)-ethylmalonyl-CoA + NADP(+) = (2E)-butenoyl-CoA + CO2 + NADPH"}, {"i": "EC:1.3.1.85", "l": "\"Crotonyl-CoA carboxylase/reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53674", "l": "2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphoethanolamine + A + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50623", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237160", "l": "MTA is cleaved and phosphorylated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11668", "l": "[(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O = [(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate"}, {"i": "EC:2.7.9.4", "l": "\"Alpha-glucan, water dikinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983421", "l": "Journey of cargo through Golgi complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004072", "l": "aspartate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686587", "l": "ABL1 phosphorylates RAD52 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0023029", "l": "MHC class Ib protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43223", "l": "guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14570", "l": "propane-1,2-diol => H2O + propanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25932", "l": "4-methylquinoline + A + H2O = 4-methylquinolin-2(1H)-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426209", "l": "DAG activation of TRPC channels (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59427", "l": "benzylamine + H2O + O2 <=> benzaldehyde + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36292", "l": "3-methylxanthine + H(+) + NADPH + O2 => formaldehyde + H2O + NADP(+) + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25479", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-himachalene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23297", "l": "N-acetylneuraminate => N-acetyl-D-mannosamine + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140351", "l": "glycosylceramide flippase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140696", "l": "factor V -> factor Va + factor V activation peptide (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380780", "l": "Activation of Src (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34197", "l": "2 aureusidin 6-O-beta-glucoside + 2 H2O => 2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24975", "l": "calcitetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (1S)-1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2509831", "l": "ITPA hydrolyses XTP to XMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8873794", "l": "PCTP binds PC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53408", "l": "(1S,4R)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 = (4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42600", "l": "AH2 + prostaglandin G2 = A + H2O + prostaglandin H2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686685", "l": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186786", "l": "Autophosphorylation of PDGF beta receptors (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9007926", "l": "ATRX binds DAXX (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21559", "l": "[calmodulin]-L-lysine + S-adenosyl-L-methionine <=> [calmodulin]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35585", "l": "D-glyceraldehyde + pyruvate => 2-dehydro-3-deoxy-D-gluconate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44997", "l": "(R)-carnitine + acetoacetyl-CoA => CoA + O-3-oxobutanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784494", "l": "EKC complex threonylcarbamoylates A37 of tRNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624272", "l": "MMPs cleave HB-EGF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791116", "l": "Expression of DDX11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454928", "l": "ABCG4 may mediate cholesterol efflux (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013147", "l": "RAC1 GDIs block activation of RAC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2995330", "l": "COX10 transforms heme to heme O (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-917693", "l": "ESCRT Disassembly (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1470009", "l": "Phosphorylation of STATs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35162", "l": "(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O <=> (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45583", "l": "D-galactaro-1,5-lactone <=> D-galactaro-1,4-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53298", "l": "(2E,4E)-decadienoyl-CoA + H(+) + NADPH => (2E)-decenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685201", "l": "CCDC59:TTF1 binds SFTPC gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6795473", "l": "PDPK1 phosphorylates SGK1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58276", "l": "6 ATP = cyclic hexaadenylate + 6 diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001639", "l": "PLC activating G protein-coupled glutamate receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41508", "l": "L-ornithine + NADPH + O2 = H2O + N(5)-hydroxy-L-ornithine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22020", "l": "ATP + H2O + molybdate(out) = ADP + H(+) + molybdate(in) + phosphate"}, {"i": "EC:7.3.2.5", "l": "\"ABC-type molybdate transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564179", "l": "Collagen type XI degradation by MMP1,2,3,9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17819", "l": "H(+) + holo-[ACP] + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => (3R)-hydroxytetradecanoyl-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40500", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O => (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626228", "l": "The distal appendage proteins recruit TTBK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20378", "l": "3alpha-hydroxy-5alpha-androstan-17-one + NADP(+) => 5alpha-androstan-3,17-dione + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46163", "l": "a quinone + H(+) + NADH <=> a quinol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "59.657777192179466", "identifiers": [{"i": "GO:0042578", "l": "phosphoric ester hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106309", "l": "progesterone 21-hydroxylase activity"}, {"i": "RHEA:50304", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47879", "l": "ganglioside GD1b + H2O <=> ganglioside GM1 + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928625", "l": "PAKs autophosphorylate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1462005", "l": "pro-defensin alpha 5 is secreted (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31103", "l": "7,8-dihydrofolate + NADP(+) = folate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44527", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-glycerol + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173631", "l": "Activation of C1s (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15042", "l": "bis-D-fructose 2',1:2,1'-dianhydride + H2O => inulobiose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20785", "l": "H2O + N(omega)-(ADP-D-ribosyl)-L-arginine => ADP-D-ribose + L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31182", "l": "(3S)-3-hydroxydodecanoyl-CoA + NAD(+) <=> 3-oxododecanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714481", "l": "RAC2 binds effectors at the ER membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662620", "l": "MT3 binds cadmium (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76386", "l": "CYP1A2 S-demethylates 6MMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008111", "l": "alpha-methylacyl-CoA racemase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421471", "l": "hydroxymethylbilane => uroporphyrinogen I + H2O (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44508", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432712", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25426", "l": "5-phospho-alpha-D-ribose 1-diphosphate + guanine => diphosphate + GMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854466", "l": "VLDLR binds RELN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49763", "l": "EDTA + FMNH2 + O2 <=> ethylenediaminetriacetate + FMN + glyoxylate + 2 H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20743", "l": "H2O + trans-2,3-epoxysuccinate <=> (2R,3S)-tartrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15760", "l": "L-homoserine + NAD(+) <=> H(+) + L-aspartate 4-semialdehyde + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10465", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O => n acetate + chitosan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.58"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10814", "l": "2 H(+) + N-succinyl-L-glutamate + NADH => H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.40", "l": "\"Bleomycin hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43622", "l": "aminoacetaldehyde + CO2 + NADPH => L-serine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47108", "l": "cholate + taurine = H2O + taurocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40042", "l": "2 ATP + 2 L-glutamate + N-acetyl-L-aspartate <=> 2 ADP + 2 H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10236", "l": "trans-2-coumarate + UDP-alpha-D-glucose = H(+) + trans-beta-D-glucosyl-2-hydroxycinnamate + UDP"}, {"i": "EC:2.4.1.114", "l": "\"2-coumarate O-beta-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62170", "l": "acetate + beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine => H2O + N,N'-diacetylchitobiose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696670", "l": "CHD1L is recruited to GG-NER site (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602484", "l": "Activation of proMMP11 by FURIN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685604", "l": "SLAMF6 binds SLAMF6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15934", "l": "(S)-propane-1,2-diol + NAD(+) => (S)-lactaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13760", "l": "(Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose <=> (Z)-desulfoglucotropeolin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13430", "l": "2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) => 4-CDP-2-C-methyl-D-erythritol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-453338", "l": "PGYM b dimer:AMP complex <=> PGYM dimer, b form + 2 AMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2032781", "l": "WWTR1 (TAZ) binds TEAD (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55237", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H2O => (9Z)-octadecenoate + 1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043841", "l": "(S)-lactate 2-kinase activity"}, {"i": "MetaCyc:RXN-8076"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53742", "l": "[Rab1 protein]-L-tyrosine + AMP + H(+) => [Rab1 protein]-O(4)-(5'-adenylyl)-L-tyrosine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391211", "l": "Trace amine-associated receptors can bind trace amines (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41408", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54576", "l": "2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2 = an adenosine in tRNA + CO2 + formaldehyde + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013024", "l": "RHOB binds effectors at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24381", "l": "(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) => (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005471", "l": "ATP:ADP antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687097", "l": "p-S857 NCOA3 binds ETV4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390425", "l": "FAR1 reduces PalmCoA to HXOL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25882", "l": "2 3-(3,4-dihydroxyphenyl)pyruvate + 2 NH4(+) => 2 L-dopa + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30229", "l": "2 [Fe(II)-cytochrome c2] + dimethyl sulfoxide + 2 H(+) => 2 [Fe(III)-cytochrome c2] + dimethyl sulfide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9639286", "l": "RRAGC,D exchanges GTP for GDP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047594", "l": "6-beta-hydroxyhyoscyamine epoxidase activity"}, {"i": "RHEA:12797", "l": "(6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 = CO2 + H(+) + H2O + scopolamine + succinate"}, {"i": "EC:1.14.20.13", "l": "\"6-beta-hydroxyhyoscyamine epoxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56394", "l": "(3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+) => [(3R)-hydroxybutanoate](n) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55497", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta,3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18857", "l": "lithocholate + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxylithocholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.138", "l": "\"Lithocholate 6-beta-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.12"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-392530", "l": "p-S400-Cot phosphorylates NIK (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45618", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexanoyl ethanolamine => H2O + N-hexanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12503", "l": "NADP(+) + thiomorpholine-3-carboxylate <=> 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.98.-", "l": "\"With other, known, acceptors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54098", "l": "H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17909", "l": "(S)-lactate = acetaldehyde + formate"}, {"i": "EC:4.1.2.36", "l": "\"Lactate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8863472", "l": "DAB2 binds LRP2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42864", "l": "norspermidine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + norspermine + S-methyl-5'-thioadenosine"}, {"i": "EC:2.5.1.126", "l": "\"Norspermine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14333", "l": "a 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol"}, {"i": "EC:4.6.1.14", "l": "\"Glycosylphosphatidylinositol diacylglycerol-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56555", "l": "ATP + L-threonyl-[rhodopsin] <=> ADP + H(+) + O-phospho-L-threonyl-[rhodopsin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54018", "l": "(8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48534", "l": "ganglioside GT1c (d18:1(4E)) + N-acetylneuraminate => ganglioside GQ1c (d18:1(4E)) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986972", "l": "IL24 binds IL20RA:JAK1:IL20RB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25514", "l": "chorismate + L-glutamine => (2S)-2-amino-4-deoxychorismate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36116", "l": "gibberellin A3 + S-adenosyl-L-methionine => O-methyl gibberellin A3 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22285", "l": "2 H(+) + H2O + N-carbamoylputrescine => CO2 + NH4(+) + putrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4837364", "l": "Secretion of SOD3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.-", "l": "\"Peroxidases\""}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0140313", "l": "molecular sequestering activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26154", "l": "6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate => (2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21501", "l": "UDP-alpha-D-glucose => H2O + UDP-4-dehydro-6-deoxy-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664991", "l": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17666", "l": "L-lysyl-[protein] + octanoyl-[ACP] => H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30693", "l": "formaldehyde + 2 H2O => H2O2 + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2562564", "l": "Caspase-8 processing within TLR4 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15665", "l": "aldehydo-D-glucose + L-lysyl-[protein] = H2O + N(6)-(D-fructosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47435", "l": "(7Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167597", "l": "Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170674", "l": "Dissociation of the Gi alpha:G olf complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55921", "l": "[cis-1,4-isoprene](n) + O2 => (4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal + cis-1,4-isoprene(n-3)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40385", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24305", "l": "glycine + H(+) + N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] => (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199566", "l": "KIR3DL1 interacting with HLA Bw4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937807", "l": "SRC phosphorylates RUNX3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28849", "l": "Li(+)(out) + melibiose(out) => Li(+)(in) + melibiose(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62257", "l": "Cd(2+)(out) + 2 hydrogencarbonate(out) => Cd(2+)(in) + 2 hydrogencarbonate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54263", "l": "2-oxoglutarate + L-asparaginyl-[protein] + O2 <=> (3S)-3-hydroxy-L-asparaginyl-[protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16939", "l": "1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+) => 1-O-alkyl-sn-glycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59694", "l": "D-cellotrionate + H(+) => D-cellotriono-1,5-lactone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705738", "l": "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.24", "l": "\"Cathepsin T\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26243", "l": "diphosphate + elisabethatriene => geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018854", "l": "3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209921", "l": "Monoiodinated tyrosine can be deiodinated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42658", "l": "diphthine-[translation elongation factor 2] + H(+) + methanol => diphthine methyl ester-[translation elongation factor 2] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362522", "l": "ALDHs oxidise atRAL to atRA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901242", "l": "ABC-type doxorubicin transporter activity"}, {"i": "TCDB:3.A.1.105.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382056", "l": "Crk binds to the active PDGF receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28260", "l": "cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP => cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353356", "l": "Reversal of Alkylation Damage By DNA Dioxygenases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183122", "l": "Factor D cleaves C3b-bound Factor B (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676133", "l": "CD74 binds MIF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.9.-.-", "l": "\"Transferring selenium-containing groups\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32954", "l": "sucrose <=> trehalulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170986", "l": "Ral-GDS binds to Ras-GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24513", "l": "L-serine + pyrazole => 3-(pyrazol-1-yl)-L-alanine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25980", "l": "(5S)-albaflavenol + H(+) + NADPH + O2 = albaflavenone + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10041", "l": "adenosine 3',5'-bisphosphate + H2O => AMP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446694", "l": "IRAK4 phosphorylates IRAK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015608", "l": "carbohydrate-importing ABC transporter activity"}, {"i": "TCDB:3.A.1.1.1"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047171", "l": "glucarolactone O-hydroxycinnamoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3296301", "l": "CCRL2 binds CCL19 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1028817", "l": "CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003843", "l": "1,3-beta-D-glucan synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9632412", "l": "PTK2 is recruited to methylated ESR1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33563", "l": "(4R)-hydroxysphinganine + ATP = (4R)-hydroxysphinganine 1-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222353", "l": "Protonation of superoxide (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351201", "l": "N-acetylated spermidine (cytosol)=>N-acetylated spermidine (peroxisomal) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47825", "l": "H(+) + malonyl-[ACP] + octadecanoyl-[ACP] => 3-oxoeicosanoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59333", "l": "1'-hydroxy-gamma-carotene + A => 1'-hydroxytorulene + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9688456", "l": "MLKL binds FLOT1, FLOT2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48119", "l": "L-arginyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-372843", "l": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33889", "l": "(-)-matairesinol + 2 H(+) + 2 NADH => (-)-secoisolariciresinol + 2 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033843", "l": "xyloglucan 6-xylosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707051", "l": "UBXN1 binds BRCA1:BARD1 heterodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63135", "l": "apo--[alkylcobalamin reductase] + glutathione + methylcob(III)alamin <=> cob(I)alamin--[alkylcobalamin reductase] + H(+) + S-methyl glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45426", "l": "(9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47635", "l": "H2O + L-arginine + NAD(+) <=> 5-guanidino-2-oxopentanoate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15133", "l": "H2O + L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + NADH + NH4(+)"}, {"i": "EC:1.4.1.2", "l": "\"Glutamate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18921", "l": "5alpha-cholest-7-en-3beta-ol + H(+) + NADH + O2 = cholesta-5,7-dien-3beta-ol + 2 H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13770", "l": "glycerol + NAD(+) => dihydroxyacetone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022935", "l": "MECP2 binds GAD1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729870", "l": "KCNJ2 (KIR2.1) transports K+ from the extracellular region to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855375", "l": "PTPN22 dissociates from CSK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45605", "l": "D-glucaro-1,4-lactone => 5-dehydro-4-deoxy-D-glucarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.22", "l": "\"Stromelysin 2\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.2", "l": "\"ABC-type nonpolar-amino-acid transporter\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030378", "l": "serine racemase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77589", "l": "Recognition of AAUAAA sequence by CPSF (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55063", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 12-oxojasmonyl-L-alpha-amino acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654159", "l": "Activated FGFR2 binds PLCG1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015306", "l": "sialate:cation symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29641", "l": "alpha-D-glucose + alpha-maltopentaose => alpha-maltohexaose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12881", "l": "ADP-alpha-D-glucose + sn-glycerol 3-phosphate = 2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + ADP + H(+)"}, {"i": "EC:2.4.1.213", "l": "\"Glucosylglycerol-phosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450533", "l": "PKCdelta phosphorylates HuR (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44293", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CDP-ethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103100", "l": "UDP-glucose: 6-methylthiohexylhydroximate S-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52429", "l": "12-oxo-leukotriene B4 + H(+) + NADH => 12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49908", "l": "(R)-carnitine(out) + O-acetyl-(R)-carnitine(in) = (R)-carnitine(in) + O-acetyl-(R)-carnitine(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0015377", "l": "cation:chloride symporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0001221", "l": "transcription coregulator binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706323", "l": "Active FLT3 binds to SLA2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49031", "l": "(-)-bursehernin + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-5'-demethylyatein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031459", "l": "ABC-type glycine betaine transporter activity"}, {"i": "RHEA:32783", "l": "ATP + glycine betaine(out) + H2O = ADP + glycine betaine(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21816", "l": "a D-alpha-amino acid + H2O + O2 = a 2-oxocarboxylate + H2O2 + NH4(+)"}, {"i": "RHEA:37583", "l": "D-lysine + H2O + O2 = 6-amino-2-oxohexanoate + H2O2 + NH4(+)"}, {"i": "EC:1.4.3.3", "l": "\"D-amino-acid oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41549", "l": "8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine => 8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201629", "l": "Caspase-mediated cleavage of Tau (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39700", "l": "(R)-3-hydroxy-(13Z)-eicosenoyl-CoA => (2E,13Z)-eicosadienoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19723", "l": "(9Z)-octadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58769", "l": "1-O-(1Z-hexadecenyl)-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-O-(1Z-hexadecenyl)-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36905", "l": "7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine => 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33689", "l": "CoA + H(+) + taxol => 3'-N-debenzoyltaxol + benzoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32991", "l": "2 a 1-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654510", "l": "FGFRL1 binds SPRED1/2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45211", "l": "[methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M <=> [Co(I) methanol-specific corrinoid protein] + H(+) + methyl-coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54802", "l": "[nsP1 protein]-L-histidine + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA => [nsP1 protein]-N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidine + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869568", "l": "NPM1 binds TFAP2A homodimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2002428", "l": "Removal of fibrillar collagen N-propeptides (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862300", "l": "LYZ binds bacterial peptidoglycan (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36820", "l": "(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30671", "l": "H2O + N,N'-diacetylchitobiose = 2 N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50650", "l": "2-(2-methylsulfanyl)ethylmaleate + H2O => 2-(2-methylsulfanyl)ethylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43034", "l": "2-aminoprop-2-enoate + chloride + H(+) => 3-chloro-D-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43146", "l": "H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine => adenosine(22) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5638006", "l": "ARL3 hydrolyzes GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454208", "l": "Phosphorylation of beta and gamma subunits by LYN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61647", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L-arginine <=> 2 [Fe(III)-cytochrome b5] + H2O + L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59153", "l": "ATP + CoA + pseudomonate C => AMP + diphosphate + pseudomonoyl-CoA C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2169046", "l": "Degradation of TGF-beta receptor complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42900", "l": "guanosine(745) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.187", "l": "\"23S rRNA (guanine(745)-N(1))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714691", "l": "RAC3 binds ER effectors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52920", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247844", "l": "WNT ligands traffic to the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419843", "l": "CALCA(83-119) binds CALCR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632038", "l": "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48810", "l": "(5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60142", "l": "3-oxotetradecanoyl-CoA + CO2 + CoA => dodecanoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371567", "l": "DBC1 is phosphorylated by ATM/ART (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050333", "l": "thiamin-triphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34778", "l": "a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) <=> a 3-oxosteroid + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173626", "l": "Activation of C1r (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-981539", "l": "C3b binds to cell surface (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39584", "l": "(2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H(+) + NADPH => (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29992", "l": "H(+)(in) + L-lyxose(in) => H(+)(out) + L-lyxose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48504", "l": "D-glycero-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-D-manno-heptose 1-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917700", "l": "MVB Vesicle Formation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32928", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => a 1,2-diacyl-sn-glycerol + H(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27907", "l": "butanoyl-CoA + NADP(+) => (2E)-butenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850961", "l": "PREX2 binds PTEN and inhibits it (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56539", "l": "(12R)-hydroxy-(9Z)-octadecenoyl-CoA + 1,2-di-(12R-hydroxy-9Z-octadecenoyl)-sn-glycerol <=> 1,2,3-tri-(12R-hydroxy-9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13942", "l": "ATP + D-glyceraldehyde => ADP + D-glyceraldehyde 3-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033867", "l": "Fas-activated serine/threonine kinase activity"}, {"i": "MetaCyc:2.7.11.8-RXN"}, {"i": "EC:2.7.11.8", "l": "\"Fas-activated serine/threonine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29804", "l": "ATP + H2O + L-valine(in) => ADP + H(+) + L-valine(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43601", "l": "3-oxoeicosanoyl-[ACP] + H(+) + NADPH => 3R-hydroxyeicosanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11390", "l": "an 11-oxosteroid + H(+) + NADPH => an 11beta-hydroxysteroid + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27382", "l": "(2R)-2,3-bisphosphoglycerate + H2O => (2R)-2-phosphoglycerate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088281", "l": "Endorepellin binds KDR (VEGFR2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27829", "l": "hydrogen sulfide + O-succinyl-L-homoserine <=> L-homocysteine + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65259", "l": "AH2 + O2 + verruculide C <=> A + H2O + verruculide C epoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45139", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate <=> 7,8-dihydroneopterin 3'-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102851", "l": "1-18:2-2-16:0-phosphatidylglycerol desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28207", "l": "2'-deoxyuridine + ATP => ADP + dUMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692437", "l": "ANG binds F-actin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0004860", "l": "protein kinase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132104", "l": "Complement factor B binds to the hydrolyzed form of C3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54501", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => beta-geranylfarnesene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77608", "l": "Binding of A1CF to stem-looped RNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008437", "l": "thyrotropin-releasing hormone activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56369", "l": "3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 => 3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167983", "l": "C-ter TLR7 dimer bind TLR7, TLR8 ligands (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41184", "l": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-octadecyl-sn-glycero-3-phosphocholine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190686", "l": "Transport of connexins to the Trans-Golgi Network (TGN) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012835", "l": "GDIs block activation of RHOA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32246", "l": "alpha-D-ribose 1,5-bisphosphate <=> D-ribulose 1,5-bisphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9688456", "l": "MLKL binds FLOT1, FLOT2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51738", "l": "H(+) + N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => L-lysyl-[protein] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15518", "l": "H2O + N(2),6-disulfo-D-glucosamine => H(+) + N-sulfo-D-glucosamine + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33673", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + O2 => 2 [Fe(III)-cytochrome b5] + an N-(2,3-dihydroxyhexacosanoyl)-(4R)-hydroxysphinganine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15978", "l": "(S)-4-hydroxymandelonitrile => 4-hydroxybenzaldehyde + hydrogen cyanide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21862", "l": "adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3',7-trissulfate => 3'-phosphoadenylyl sulfate + quercetin 3,3'-bissulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63626", "l": "AMP + H(+) + hexadecanoyl-[ACP] => hexadecanoyl-AMP + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45110", "l": "13-hydroxy-alpha-tocopherol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578965", "l": "TNRC6A binds AGO2:miRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.7"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990650", "l": "inositol-2,4,5,6-tetrakisphosphate 5-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31464", "l": "crocetin + UDP-alpha-D-glucose => beta-D-glucosyl crocetin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13887", "l": "CO2 + stipitatate => H2O + stipitatonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213207", "l": "Formation of collagen networks (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30411", "l": "benzoyl-CoA + benzyl alcohol = benzyl benzoate + CoA"}, {"i": "EC:2.3.1.196", "l": "\"Benzyl alcohol O-benzoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23186", "l": "(6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate => (6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39589", "l": "(3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+) => 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.127", "l": "\"1,6-alpha-L-fucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141409", "l": "Mad1 binds kinetochore (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38062", "l": "2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA <=> 1-octanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855232", "l": "RELN:VLDLR binds DAB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102769", "l": "dihydroceramide glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62636", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O"}, {"i": "EC:1.11.1.28", "l": "\"Lipoyl-dependent peroxiredoxin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5674140", "l": "PAQR3 binds inactive RAFs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451311", "l": "Activation of Ca-permeable Kainate receptors (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23629", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2176445", "l": "SMURF2 binds SMAD2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432647", "l": "Phosphorylated PER binds to TIM (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102941", "l": "3,5-dihydroxyanisole O-methyltransferase activity"}, {"i": "MetaCyc:RXN-9021"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031772", "l": "type 2 hypocretin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647632", "l": "CASP3 cleaves GSDME (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20119", "l": "ADP + H(+) + L-rhamnulose 1-phosphate => ATP + L-rhamnulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003855", "l": "3-dehydroquinate dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444691", "l": "Prokineticin receptors bind prokineticin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703432", "l": "p-STAT5 dissociates from FLT3 fusion proteinsp- (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62629", "l": "a hydroperoxide + H(+) + NADH => an alcohol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64476", "l": "4-[(2E,7S,8E,10E,13R,14R,16E,18E)-14-ethyl-7,13-dihydroxy-2,16,18-trimethylicosa-2,8,10,16,18-pentaenoyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate = 4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31408", "l": "all-trans-4,4'-diaponeurosporene + FAD + H(+) => all-trans-4,4'-diapolycopene + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16917", "l": "2,6-dihydroxypyridine + H(+) + NADH + O2 = 2,3,6-trihydroxypyridine + H2O + NAD(+)"}, {"i": "EC:1.14.13.10", "l": "\"2,6-dihydroxypyridine 3-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16293", "l": "2-isopropylmaleate + H2O = (2S)-2-isopropylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211951", "l": "CYP1B1 4-hydroxylates EST17b (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13209", "l": "A + 3 H2O + trithionate = AH2 + 4 H(+) + 3 sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111962", "l": "PDE4A,C,D hydrolyse cAMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031707", "l": "endothelin A receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22053", "l": "A + H2O + NH4(+) => AH2 + H(+) + hydroxylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655483", "l": "USP1 autocleavage (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433454", "l": "Phosphorylation of GAB2 by SFKs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20790", "l": "ADP-D-ribose 1''-phosphate + H(+) + nicotinamide => NAD(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139920", "l": "Translocation of tBID to mitochondria (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36796", "l": "a ribonucleoside 5'-triphosphate + 2 H2O => a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61501", "l": "delphinidin + UDP-alpha-D-glucose => delphinidin 3-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27875", "l": "isochorismate => pyruvate + salicylate"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004074", "l": "biliverdin reductase (NAD(P)+) activity"}, {"i": "REACT:R-HSA-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13112", "l": "2-acetamidofluorene + H2O + NAD(+) <=> H(+) + N-hydroxy-2-acetamidofluorene + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050127", "l": "N-carbamoylsarcosine amidase activity"}, {"i": "RHEA:20057", "l": "2 H(+) + H2O + N-carbamoylsarcosine = CO2 + NH4(+) + sarcosine"}, {"i": "EC:3.5.1.59", "l": "\"N-carbamoylsarcosine amidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19203", "l": "ADP + dGMP + H(+) => 2'-deoxyguanosine + ATP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052580", "l": "(+)-pulegone reductase, (-)-menthone as substrate, activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24478", "l": "H(+) + maleamate => H2O + maleimide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56148", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphocholine = CoA + hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24597", "l": "acetyl-CoA + L-histidine => CoA + H(+) + N(alpha)-acetyl-L-histidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626681", "l": "Recruitment of transition zone proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426223", "l": "Cation influx mediated by TRPC3/6/7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54377", "l": "(+)-copalyl diphosphate + H2O => diphosphate + nezukol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38916", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55135", "l": "ATP + D-alanine + holo-[D-alanyl-carrier protein] <=> AMP + D-alanyl-[D-alanyl-carrier protein] + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9669854", "l": "KIT binds type II TKIs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52056", "l": "12-hexadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062183", "l": "all-trans retinoic acid 18-hydroxylase activity"}, {"i": "RHEA:55856", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19793", "l": "H(+) + H2O + oxidized [electron-transfer flavoprotein] + sarcosine = formaldehyde + glycine + reduced [electron-transfer flavoprotein]"}, {"i": "EC:1.5.8.3", "l": "\"Sarcosine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62427", "l": "(E)-caffeoyl-CoA + H2O <=> 3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51780", "l": "4-prenylphlormethylbutanophenone + dimethylallyl diphosphate = deoxyadlupulone + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54777", "l": "1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine => [LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001588", "l": "dopamine neurotransmitter receptor activity, coupled via Gs"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30733", "l": "(2E)-butenoyl-CoA + FADH2 => butanoyl-CoA + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17271", "l": "H(+) + S-adenosyl-L-homocysteine + tylosin => macrocin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856189", "l": "TNFSF8 binds TNFRSF8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008713", "l": "ADP-heptose-lipopolysaccharide heptosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050200", "l": "plasmalogen synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25735", "l": "L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62388", "l": "[(1->2)-beta-D-glucosyl](n) + H2O = [(1->2)-beta-D-glucosyl](n-2) + sophorose"}, {"i": "EC:3.2.1.214", "l": "\"Exo beta-1,2-glucooligosaccharide sophorohydrolase (non-reducing end)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209332", "l": "LGS dissociates from the PYGO complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10362", "l": "3-(2-hydroxyphenyl)propanoate + H(+) => 3,4-dihydrocoumarin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45282", "l": "12-hydroxyoctadecanoate + phosphate => 12-(phosphooxy)octadecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54206", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56551", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43109", "l": "2 [Fe(III)cytochrome c] + H2O + N2 => 2 [Fe(II)cytochrome c] + 2 H(+) + nitrous oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49252", "l": "D-fructose(out) + N(pros)-phospho-L-histidyl-[protein] = D-fructose 1-phosphate(in) + L-histidyl-[protein]"}, {"i": "EC:2.7.1.202", "l": "\"Protein-N(pi)-phosphohistidine--D-fructose phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63501", "l": "H(+) + NADPH + S-nitrosoglutathione => NADP(+) + sulfinamide glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873919", "l": "Phosphorylation of JAK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2731141", "l": "Syndecan-1 binds fibronectin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49249", "l": "galactitol(out) + N(pros)-phospho-L-histidyl-[protein] => galactitol 1-phosphate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50217", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63762", "l": "1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0016493", "l": "C-C chemokine receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62055", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphate + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102763", "l": "phytyl-P kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388817", "l": "ICOS binds ICOSL/B7-H2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17222", "l": "dTDP-alpha-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102208", "l": "2-polyprenyl-6-hydroxyphenol methylase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090556", "l": "phosphatidylserine floppase activity"}, {"i": "RHEA:38567", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-448958", "l": "Nuclear translocation of p38 MAPK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50586", "l": "15-oxoprostaglandin E1 + H(+) + NADPH => 13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47051", "l": "a quinone + shikimate <=> 3-dehydroshikimate + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707505", "l": "Hemes bind to CLEC1B dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28406", "l": "H2O + XTP = H(+) + phosphate + XDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50870", "l": "(5,12,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoate => (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205286", "l": "GRB2:SOS interacts with p-KIT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9670014", "l": "Factor VIIIa dissociates  (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16271", "l": "4-(dimethylamino)azobenzene + 2 H(+) + 2 NADPH => aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11864", "l": "H(+) + H2O + oxidized [electron-transfer flavoprotein] + trimethylamine = dimethylamine + formaldehyde + reduced [electron-transfer flavoprotein]"}, {"i": "EC:1.5.8.2", "l": "\"Trimethylamine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59071", "l": "demethyldeoxyspectinabilin + S-adenosyl-L-methionine <=> deoxyspectinabilin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13819", "l": "2,3-epoxyphylloquinone + [protein]-dithiol => [protein]-disulfide + H2O + phylloquinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166015", "l": "Association of LBP with LPS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-434836", "l": "Syk/Lck phosphorylate LAT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48412", "l": "globoside IV3GalNAc-Gb4Cer + H2O = globoside Gb4Cer + N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48531", "l": "ganglioside GP1c (d18:1(4E)) + H2O <=> ganglioside GQ1c (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681294", "l": "IL6R binds IL6R inhibitors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49684", "l": "H(+) + NADH + O2 + resorcinol = benzene-1,2,4-triol + H2O + NAD(+)"}, {"i": "EC:1.14.13.220", "l": "\"Resorcinol 4-hydroxylase (NADH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53563", "l": "9,10-epoxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-9,10-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49540", "l": "(2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate = (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042242", "l": "cobyrinic acid a,c-diamide synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14046", "l": "1-carboxyvinyl carboxyphosphonate + H(+) => 3-(hydrohydroxyphosphoryl)pyruvate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46385", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 24S,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5667037", "l": "RHPN2 binds RHOB:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56667", "l": "7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD(+) <=> 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197690", "l": "Detachment of WASP/WAVE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67079", "l": "L-histidyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38908", "l": "(R)-reticuline + S-adenosyl-L-methionine => (R)-laudanine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878266", "l": "IHH gene transcription is stimulated by RUNX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696271", "l": "RND1 binds effectors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49799", "l": "an N-(fatty acyl)-glycine + H2O <=> a fatty acid + glycine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018829", "l": "1,1-dichloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9737780", "l": "MTTP binds lomitapide (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52770", "l": "2-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + L-glutamate => 2-(glutathion-S-yl)-2-(1H-indol-3-yl)acetonitrile + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602458", "l": "Activation of proMMP10 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "68.265052123604846", "identifiers": [{"i": "GO:0015103", "l": "inorganic anion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58583", "l": "dihydroprecondylocarpine acetate <=> acetate + catharanthine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40164", "l": "D-glyceraldehyde + H2O + NADP(+) => (R)-glycerate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388814", "l": "Grb2 binds CD28 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358790", "l": "RNF41 ubiquitinates ERBB3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23941", "l": "D-gluconate + NAD(+) => 5-dehydro-D-gluconate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54276", "l": "2-oxoglutarate + L-aspartyl-[protein] + O2 = (3S)-3-hydroxy-L-aspartyl-[protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5604929", "l": "Activated protein C binds Protein S (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849085", "l": "ARHGAP35 binds RHOA:GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57369", "l": "H2O + NADPH => (6R)-NADPHX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209320", "l": "Activated TAK1 kinase is autophosphorylated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1299318", "l": "Activation of TASK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3781941", "l": "WNTs are secreted in exosomes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69891", "l": "Phosphorylation and activation of CHEK2 by ATM (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416725", "l": "SEMA6D binds to PLXNA1:TREM2:DAP12 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48786", "l": "D-erythrose 4-phosphate => D-erythrulose 4-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34489", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + dTDP + H(+) => dTDP-beta-L-rhamnose + N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0016697", "l": "oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor"}, {"i": "EC:1.12.2.-", "l": "\"With a cytochrome as acceptor\""}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0072374", "l": "carotene epsilon hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53871", "l": "2 H(+) + NADH + O2 + phenazine-1-carboxylate <=> 1-hydroxyphenazine + CO2 + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47062", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043908", "l": "Ser(Gly)-tRNA(Ala) hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20892", "l": "butanoyl-CoA + phosphate = butanoyl phosphate + CoA"}, {"i": "EC:2.3.1.19", "l": "\"Phosphate butyryltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102900", "l": "dehydroabietadienal hydroxylase activity"}, {"i": "MetaCyc:RXN-8534"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39740", "l": "3-hydroxydodecanoate + H(+) + NADPH + O2 => 3,12-dihydroxydodecanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624112", "l": "CEBPA binds CDK4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72722", "l": "eIF2 activation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40127", "l": "an omega-oxo fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = a dicarboxylate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45950", "l": "CoA + H(+) + N(6)-acetyl-L-lysyl-[protein] => acetyl-CoA + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.148"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878914", "l": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52776", "l": "2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = camalexin + CO2 + 2 H(+) + 4 H2O + hydrogen cyanide + 2 oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.19.52", "l": "\"Camalexin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804596", "l": "APAF1:CYCS binds APIP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218832", "l": "CDC42:GTP binds PAK2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53237", "l": "cholesta-5,24-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => cholesta-5,24Z-dien-3beta,27-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61320", "l": "(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + parthenolide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14838", "l": "glyoxylate + H2O + O2 => H(+) + H2O2 + oxalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37805", "l": "1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43094", "l": "2'-O-methyluridine(2479) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2479) in 23S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37349", "l": "ADP + D-alanyl-(R)-lactate + phosphate => (R)-lactate + ATP + D-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12903", "l": "D-ornithine + urea => D-arginine + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018562", "l": "3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "78.819800280251172", "identifiers": [{"i": "GO:0046914", "l": "transition metal ion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163310", "l": "TFAM binds to mitochondrial promoters (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-996727", "l": "REST recruits the BHC complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19274", "l": "H2O + N-acetyl-D-mannosamine + phosphoenolpyruvate => N-acetylneuraminate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5444523", "l": "Formation of MSH1:PMS2 Complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018867", "l": "5-HEDH dehydrogenates 5(S)-Hp-18(S)-HpEPE to 18(S)-RvE2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12006", "l": "H(+) + indican + UDP => indoxyl + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507869", "l": "Aquaporins passively transport glycerol into cells (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209828", "l": "Tryptophan is hydroxylated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33261", "l": "N-formimidoylglycine + NH4(+) => 4-aminoimidazole + H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45250", "l": "butanoate(in) => butanoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16606", "l": "dodecanoyl-CoA + H2O + oxaloacetate => (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-443831", "l": "14-3-3-zeta binds Raf1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40142", "l": "(9Z)-octadecenoyl-CoA + H2O <=> (9Z)-octadecenoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19582", "l": "N(6)-dimethylallyladenine + S-adenosyl-L-methionine => discadenine + H(+) + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624120", "l": "CEBPA binds CDK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53166", "l": "a 1-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+) => H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848726", "l": "PTK6 phosphorylates BCAR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250220", "l": "Homodimerization of ERBB4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080013", "l": "(E,E)-geranyllinalool synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693598", "l": "ATM phosphorylates NBN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22522", "l": "all-trans-retinoate + H(+) + H2O2 => all-trans-retinal + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609746", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN2B (GRIN2B) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63257", "l": "1-octadecanoyl-2-(15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O => 1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654422", "l": "Activated FGFR4 binds FRS2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60416", "l": "diglucosyl-enterobactin + H2O = H(+) + N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56462", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine => H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46914", "l": "H(+) + juvenile hormone III carboxylate + methanol => H2O + juvenile hormone III"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36921", "l": "3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 + CoA => (17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12682", "l": "creatinine + H(+) + H2O => N-methylhydantoin + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34388", "l": "beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + UDP-alpha-D-galactofuranose => beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38936", "l": "cyclohexane-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => cyclohex-1-ene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56016", "l": "H2O + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14900", "l": "apigenin + 3 H(+) + 2 NADPH + O2 <=> 2-hydroxy-2,3-dihydrogenistein + H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21387", "l": "L-phenylalanine <=> (E)-cinnamate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134800", "l": "STING dimerization (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31351", "l": "lupan-3beta,20-diol = (S)-2,3-epoxysqualene + H2O"}, {"i": "EC:4.2.1.128", "l": "\"Lupan-3-beta,20-diol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670049", "l": "Defects in F8 A1 domain accelerate dissociation of the A2 domain (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667638", "l": "NBEA translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48528", "l": "ganglioside GP1c (d18:1(4E)) + H2O = ganglioside GQ1c (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30675", "l": "tetrahymanol = H2O + squalene"}, {"i": "EC:4.2.1.123", "l": "\"Tetrahymanol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709831", "l": "HSP90 binds TBK1 and IRF3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36643", "l": "emodin + S-adenosyl-L-methionine = H(+) + questin + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.283", "l": "\"Emodin O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16794", "l": "H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine => CO2 + D-pantetheine 4'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66608", "l": "(tRNA)-3'-end (ribonucleoside 5'-phosphate)-(guanosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(adenosine 5'-phosphate) + H2O = GpCpCpA + H(+) + tRNA 3'-end (3'-phosphooxy-ribonucleotide)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60018", "l": "diphosphate + sesquisabinene B => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38152", "l": "carbonyl sulfide + H2O => CO2 + H(+) + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29591", "l": "2-hydroxyethane-1-sulfonate + NADP(+) = H(+) + NADPH + sulfoacetaldehyde"}, {"i": "EC:1.1.1.313", "l": "\"Sulfoacetaldehyde reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63548", "l": "angiotensin-(1-9) + H2O = angiotensin-(1-7) + L-phenylalanyl-L-histidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25327", "l": "H(+) + phosphocholine + S-adenosyl-L-homocysteine => N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682377", "l": "LC3 de-lipidation by ATG4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19987", "l": "H(+) + NADH + S-formylglutathione => NAD(+) + S-(hydroxymethyl)glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26416", "l": "a primary amine + an aldehyde + H2O2 => a secondary aliphatic amine + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28466", "l": "pyridoxamine(in) = pyridoxamine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19570", "l": "5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine => 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41577", "l": "dTDP-beta-L-mycarose + erythronolide B => 3-O-alpha-L-mycarosylerythronolide B + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3204318", "l": "cob(II)alamin binds to MTRR:MTR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14888", "l": "H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] <=> ADP-D-ribose + L-arginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27368", "l": "bromide + S-adenosyl-L-methionine <=> bromomethane + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395764", "l": "atREs binds to nascent CM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034929", "l": "1-hydroxypyrene 7,8-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211193", "l": "Homodimerization  of DFF40 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700164", "l": "Active ALK phosphorylates FRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40796", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + L-serine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783880", "l": "PIPOX oxidises PPCA to P6C (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9664850", "l": "ATM binds PEX5 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13884", "l": "a quinone + an aldehyde + H2O <=> a carboxylate + a quinol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52517", "l": "trans-4-hydroxy-L-proline + ubiquinone-10 => (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + H(+) + ubiquinol-10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59200", "l": "ATP + docosanoate + H(+) = diphosphate + docosanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65633", "l": "a sphingoid base + tetracosanoyl-CoA => an N-tetracosanoyl-sphingoid base + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-171059", "l": "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202472", "l": "Translocation of TRAF6 to CBM complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55171", "l": "[TtuB sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) <=> [TtuB sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693347", "l": "HTR1A binds 5HT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159868", "l": "Furin cleaves pro-factor VII to factor VII (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429992", "l": "PARN deadenylates mRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110218", "l": "Cleavage of uracil by TDG glycosylase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-167408", "l": "The high affinity receptor complex binds to G-protein (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29824", "l": "chloride(in) => chloride(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042586", "l": "peptide deformylase activity"}, {"i": "RHEA:24420", "l": "H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]"}, {"i": "EC:3.5.1.88", "l": "\"Peptide deformylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11761", "l": "4 ATP + citrate + 2 H2O + 2 N(6)-acetyl-N(6)-hydroxy-L-lysine => 4 ADP + aerobactin + 4 H(+) + 4 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026917", "l": "Lipoxygenase dehydrogenates 7(S),17(S)-diHp-DHA to 7S(8)-epoxy-17(S)-HDHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102677", "l": "campesterol,NADPH:oxygen oxidoreductase activity"}, {"i": "MetaCyc:RXN-4225"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72691", "l": "Formation of the 43S pre-initiation complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13297", "l": "3 H(+) + malonyl-CoA + 2 NADH + octadecanoyl-CoA = CO2 + CoA + eicosanoyl-CoA + H2O + 2 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984994", "l": "RUNX2 binds MAF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13457", "l": "3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N(6)-lipoyl-L-lysine + H(+) = [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysine + CO2"}, {"i": "EC:1.2.4.4", "l": "\"3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611839", "l": "β3-agonists bind ADRB3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621242", "l": "CITED2 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809764", "l": "SBF1 binds MTMR2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380508", "l": "Translocation of NuMA to the centrosomes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707690", "l": "BACH1 binds MAFK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686930", "l": "RIPK3 is cleaved by CASP8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019133", "l": "choline monooxygenase activity"}, {"i": "RHEA:17769", "l": "choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.15.7", "l": "\"Choline monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49892", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2 = (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23779", "l": "ATP + L-aspartate <=> 4-phospho-L-aspartate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209903", "l": "Noradrenaline is converted to adrenaline (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49105", "l": "Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine => 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48549", "l": "[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O => [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905502", "l": "acetyl-CoA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66695", "l": "dTDP-beta-L-rhamnose + L-arginyl-[protein] <=> dTDP + H(+) + N(omega)-(alpha-L-rhamnosyl)-L-arginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46410", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63628", "l": "ATP + hexadecanoate + holo-[ACP] = AMP + diphosphate + hexadecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047864", "l": "dimethylaniline-N-oxide aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61435", "l": "(R)-8-oxocitronellyl enol + NADP(+) <=> (6E)-8-oxogeranial + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16519", "l": "aminoacetone + H(+) + NADH => (R)-1-aminopropan-2-ol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11589", "l": "A + H2O + isoquinoline => AH2 + isoquinolin-1(2H)-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445069", "l": "L1-EGFR trans-heterodimerization (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018025", "l": "calmodulin-lysine N-methyltransferase activity"}, {"i": "RHEA:21556", "l": "[calmodulin]-L-lysine + S-adenosyl-L-methionine = [calmodulin]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.60", "l": "\"Calmodulin-lysine N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807826", "l": "LDHAL6B reduces PYR to LACT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018538", "l": "epoxide carboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12843", "l": "L-alanine + pyridoxal => pyridoxamine + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008861", "l": "formate C-acetyltransferase activity"}, {"i": "RHEA:11844", "l": "acetyl-CoA + formate = CoA + pyruvate"}, {"i": "EC:2.3.1.54", "l": "\"Formate C-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29664", "l": "H(+)(in) + xanthine(in) => H(+)(out) + xanthine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60480", "l": "2 UTP = c-di-UMP + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23961", "l": "H(+) + 2 H2O2 + hexadecanoate => CO2 + 3 H2O + pentadecanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848178", "l": "STAT3 stimulates SOCS3 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46867", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli) <=> a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295599", "l": "SPRY2 translocates to the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54199", "l": "N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40317", "l": "(2E)-glutaconyl-CoA + H2O2 => glutaryl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16074", "l": "2,2-dialkylglycine + H(+) + pyruvate => CO2 + dialkyl ketone + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22951", "l": "D-tagatofuranose 1,6-bisphosphate <=> D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63820", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) = H(+) + holo-[aryl-carrier protein] + petrobactin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50092", "l": "a fatty acyl-CoA + taurine = an N-fatty acyl-taurine + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39019", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate"}, {"i": "EC:3.1.3.95", "l": "\"Phosphatidylinositol-3,5-bisphosphate 3-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018733", "l": "3,4-dihydrocoumarin hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030116", "l": "glial cell-derived neurotrophic factor receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31602", "l": "FMNH2 + NADH + O2 + thymine <=> (Z)-2-methylureidoacrylate + FMN + H(+) + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43519", "l": "2-carboxy-5-formylfuran + H2O <=> 2-carboxy-5-(dihydroxymethyl)furan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24906", "l": "L-tyrosine = (E)-4-coumarate + NH4(+)"}, {"i": "EC:4.3.1.23", "l": "\"Tyrosine ammonia-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10455", "l": "2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> (R)-dihydrocamalexate + 2 H(+) + 2 H2O + hydrogen cyanide + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807106", "l": "PTEN undergoes monoubiquitination (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042929", "l": "ferrichrome transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29180", "l": "a menaquinol + 2 O2 => a menaquinone + 2 H(+) + 2 superoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159796", "l": "Furin cleaves pro-factor IX to factor IX (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035402", "l": "histone kinase activity (H3-T11 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34719", "l": "15-methylhexadecasphing-4-enine 1-phosphate = (2E)-13-methyltetradecenal + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202164", "l": "Translocation of PDK1 to Plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5357472", "l": "PAK1-3 autophosphorylates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19192", "l": "[dihydrolipoyllysine-residue acetyltransferase]-(R)-N(6)-lipoyl-L-lysine + H(+) + pyruvate <=> [dihydrolipoyllysine-residue acetyltransferase]-(R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636296", "l": "Mce3E binds MAPK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5213466", "l": "RIPK3 is phosphorylated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62919", "l": "an N-terminal L-alpha-aminoacyl-[protein] + 3 S-adenosyl-L-methionine <=> an N-terminal trimethyl-L-alpha-aminoacyl-[protein] + 3 H(+) + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39365", "l": "(2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H2O => (3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64884", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + UMP = (6S)-5,6,7,8-tetrahydrofolate + 5-methyl-UMP + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5339535", "l": "GLTPD1 transports C1P from plasma membrane to Golgi membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61925", "l": "(2S,4R)-ketoconazole(in) + ATP + H2O => (2S,4R)-ketoconazole(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34126", "l": "3,5,7-trioxododecanoyl-CoA <=> CoA + H(+) + olivetolate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420206", "l": "Phosphorylation of SRC-1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60202", "l": "2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61476", "l": "a sphingoid base + octadecanoyl-CoA = an N-octadecanoyl-sphingoid base + CoA + H(+)"}, {"i": "EC:2.3.1.299", "l": "\"Sphingoid base N-stearoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64705", "l": "diphenylmethanol + NAD(+) => benzophenone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53761", "l": "allocholate + deoxycholoyl-CoA => allocholoyl-CoA + deoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56878", "l": "(R)-1-phenylethylamine + acetate => (R)-N-acetyl-1-phenylethylamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668415", "l": "VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24501", "l": "adenosine 5'-tetraphosphate + H2O => ATP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022764", "l": "SGK1 gene expression is inhibited by MECP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22926", "l": "dUMP + NH4(+) => dCMP + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373134", "l": "succinate + CoASH + ATP <=> succinylCoA + ADP + Pi (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41828", "l": "(3R)-hydroxyhexanoyl-[ACP] = (2E)-hexenoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35555", "l": "cyclo(L-leucyl-L-leucyl) + 4 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] + pulcherriminic acid"}, {"i": "EC:1.14.15.13", "l": "\"Pulcherriminic acid synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202969", "l": "Caspase mediated cleavage of beta-catenin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53847", "l": "glycochenodeoxycholate + NAD(+) <=> 7-oxoglycolithocholate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877385", "l": "RUNX1 binds intron 1 of IL2RA (CD25) gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2467775", "l": "Autocleavage of ESPL1 (Separase) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913675", "l": "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61429", "l": "cis-trans-nepetalactol + NAD(+) => cis-trans-nepetalactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40680", "l": "(9Z)-octadecen-1-ol + 1-hexadecanoylglycerone 3-phosphate => 1-O-(9Z)-octadecenylglycerone 3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39680", "l": "(11Z)-octadecenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449058", "l": "Interleukin-1 family are secreted (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49480", "l": "2 H2O + L-1-piperideine-6-carboxylate + NADP(+) = H(+) + L-2-aminoadipate + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0051428", "l": "peptide hormone receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45265", "l": "(9Z,12Z)-octadecadienoate(out) => (9Z,12Z)-octadecadienoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56470", "l": "(3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 FAD + 6 H2O => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 bromide + 3 FADH2 + 3 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59866", "l": "(indol-3-yl)butanoyl-L-glutamine + AMP + diphosphate + H(+) => (indol-3-yl)butanoate + ATP + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44163", "l": "1D-myo-inositol 6-phosphate + H2O <=> myo-inositol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57139", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphoserine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362386", "l": "Glycosylation of Hh (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109702", "l": "PDPK1 phosphorylates AKT2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5623643", "l": "RDH13 reduces atRAL to atROL (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603251", "l": "Defective ACTH does not bind MCR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45532", "l": "H2O + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192851", "l": "vRNA Extension (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20003", "l": "glycolate + 2 H(+) + NADH => glycolaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004378", "l": "GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61076", "l": "(-)-minovincinine + acetyl-CoA = (-)-echitovenine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0055105", "l": "ubiquitin-protein transferase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51342", "l": "10-hydroperoxy-(4Z,7Z,11E,13Z,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444433", "l": "Cho transports from the extracellular space to the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50790", "l": "(E)-pent-3-en-2-one + H(+) + NADPH => NADP(+) + pentan-2-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10882", "l": "7-methylxanthine + D-ribose + H(+) => 7-methylxanthosine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802919", "l": "RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420975", "l": "Ca impermeable AMPA receptor ligand binding (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49090", "l": "FADH2 + hydroxysqualene => FAD + H(+) + H2O + squalene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013006", "l": "RHOA:GTP translocates to the ER membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050146", "l": "nucleoside phosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62617", "l": "a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose => a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52608", "l": "2-hydroxybutanoate + NADP(+) = 2-oxobutanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65828", "l": "H2O + neryl diphosphate = diphosphate + nerol"}, {"i": "EC:3.7.1.27", "l": "\"Neryl diphosphate diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46147", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64824", "l": "1-naphthaleneacetamide + H2O = 1-naphthaleneacetate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74986", "l": "Elongation of pre-rRNA transcript (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205652", "l": "Pink1 recruits Parkin to the outer mitochondrial membrane. (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017005", "l": "3'-tyrosyl-DNA phosphodiesterase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033920", "l": "6-phospho-beta-galactosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159194", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864105", "l": "PTPN18 binds ERBB2:EGFR heterodimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48402", "l": "CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] => 2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102849", "l": "1-18:2-2-18:3-digalactosyldiacylglycerol desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40723", "l": "(9E)-octadecenoyl-CoA + H2O = (9E)-octadecenoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42766", "l": "CO2 + reduced coenzyme F420-(gamma-Glu)(n) => formate + 2 H(+) + oxidized coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052902", "l": "spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669013", "l": "EDA-3 binds EDA2R (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40586", "l": "H2O + hexanedioyl-CoA <=> CoA + H(+) + hexanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20285", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate = alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine"}, {"i": "EC:2.4.1.211", "l": "\"1,3-beta-galactosyl-N-acetylhexosamine phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45045", "l": "2 [Fe(II)cytochrome c] + H(+) + nitroxyl + O2 => 2 [Fe(III)cytochrome c] + H2O + nitrite"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047928", "l": "gibberellin beta-D-glucosyltransferase activity"}, {"i": "RHEA:20025", "l": "gibberellin A3 + UDP-alpha-D-glucose = gibberellin A3 O-beta-D-glucoside + H(+) + UDP"}, {"i": "EC:2.4.1.176", "l": "\"Gibberellin beta-D-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27309", "l": "A + D-proline <=> 1-pyrroline-2-carboxylate + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37980", "l": "2-methyl-6-phytyl-1,4-benzene-1,4-diol + S-adenosyl-L-methionine => 2,3-dimethyl-6-phytylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39756", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23931", "l": "H2O + N(8)-acetylspermidine <=> acetate + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939870", "l": "UCMA gene expression is stimulated by RUNX2 and SP7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38411", "l": "1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O = (9Z,12Z,15Z)-octadecatrienoate + 1,3-di-(9Z,12Z,15Z)-octadecatrienoylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29724", "l": "glyoxylate(in) => glyoxylate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21313", "l": "2,5-dihydroxybenzoate + H(+) => CO2 + hydroquinone"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019912", "l": "cyclin-dependent protein kinase activating kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416698", "l": "SEMA5A binds to PLXNB3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23531", "l": "citramalate + succinyl-CoA <=> citramalyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15220", "l": "ecdysone + hexadecanoyl-CoA <=> CoA + ecdysone hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848250", "l": "ACBD6 binds LCFA-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109813", "l": "GRB2-1 binds SOS1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102762", "l": "eriodictyol 4'-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-7754"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59122", "l": "2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2 => 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15696", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + AH2 <=> (R)-2-hydroxy-(9Z,12Z,15Z)-octadecatrienoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139905", "l": "Translocation of activated BAD protein to mitochondria (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46723", "l": "(3R)-hydroxyhexanoyl-CoA <=> (2E)-hexenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53779", "l": "3-sulfanylpropanoate + O2 <=> 3-sulfinopropanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38345", "l": "(20S)-ginsenoside Rg3 + D-glucose => (20S)-ginsenoside Rd + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43750", "l": "AMP + diphosphate + hexacosanoyl-CoA => ATP + CoA + hexacosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41346", "l": "(5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810392", "l": "TMEM55B translocates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24159", "l": "2-methylpropanoate + ATP <=> 2-methylpropanoyl phosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380930", "l": "Phosphorylated AMPK binds AMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37345", "l": "adenosine + phosphate => adenosine 2'-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22884", "l": "glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine"}, {"i": "EC:2.6.1.73", "l": "\"Methionine--glyoxylate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13669", "l": "5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+) = 3-hydroxy-2-methylpyridine-5-carboxylate + CO2"}, {"i": "EC:4.1.1.51", "l": "\"3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30827", "l": "UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034851", "l": "2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59259", "l": "Fe(III)-enterobactin + H2O <=> Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632958", "l": "PMS2 variants-defective DNA mismatch repair (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24477", "l": "H2O + maleimide => H(+) + maleamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814678", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112265", "l": "thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26392", "l": "all-trans-beta-carotene + O2 <=> all-trans-10'-apo-beta-carotenal + beta-ionone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58064", "l": "O2 + reduced [NADPH--hemoprotein reductase] + xanthotoxin = 5-hydroxyxanthotoxin + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482772", "l": "Release of platelet cytosolic components (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36836", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34181", "l": "D-glucuronate + H(+) + mycophenolate => H2O + mycophenolic acid O-acyl-beta-D-glucuronide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.-", "l": "\"Phosphotransferases with an alcohol group as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72107", "l": "Formation of the Spliceosomal E complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41417", "l": "1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O => 1,2-dioctanoyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48326", "l": "ganglioside Fuc-GD1b + GDP + H(+) => ganglioside GD1b + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60067", "l": "a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2 <=> a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55640", "l": "C-terminal L-cysteinyl-[HypE protein] + carbamoyl adenylate = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57671", "l": "alpha-nootkatol + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-nootkatone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13084", "l": "biotin amide + H2O <=> biotin + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641134", "l": "SMURF2 binds AXIN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033894", "l": "ribonuclease P4 activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47708", "l": "ADP + alpha-D-glucose 1-phosphate + H(+) = ADP-alpha-D-glucose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43110", "l": "2 [Fe(II)cytochrome c] + 2 H(+) + nitrous oxide => 2 [Fe(III)cytochrome c] + H2O + N2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12788", "l": "an alditol + NAD(+) <=> an aldose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606273", "l": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427514", "l": "eNoSC deacetylates histone H3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28740", "l": "Cd(2+)(in) + H(+)(out) => Cd(2+)(out) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11535", "l": "glycine + H2O + O2 <=> glyoxylate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57601", "l": "2 [Fe(II)-cytochrome b5] + a 1-hexacosanoyl-2-acyl-phosphoglycerolipid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a 1-[(17Z)-hexacos-17-enoyl]-2-acyl-phosphoglycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5251942", "l": "Hikeshi binds HSP70s:ATP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44735", "l": "2-(9Z,12Z-octadecadienoyl)-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21155", "l": "trans-4-hydroxy-L-proline <=> cis-4-hydroxy-D-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61295", "l": "(R)-pantoate + NAD(+) <=> 2-dehydropantoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604471", "l": "FLT4 gene expression is stimulated by NOTCH4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38732", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18522", "l": "licodione + S-adenosyl-L-methionine => 2'-O-methyllicodione + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58054", "l": "(2-acetamidoethyl)phosphonate + CoA + H(+) => (2-aminoethyl)phosphonate + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3858489", "l": "ppDVL binds DAAM1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13514", "l": "(S)-dihydroorotate + NAD(+) => H(+) + NADH + orotate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391905", "l": "Oxoeicosanoid receptor can bind oxoeicosanoid (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032041", "l": "NAD-dependent histone deacetylase activity (H3-K14 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139941", "l": "Binding of IP3 to IP3 receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64579", "l": "2 [Fe(III)-cytochrome b5] + NADPH <=> 2 [Fe(II)-cytochrome b5] + H(+) + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53473", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43214", "l": "2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47532", "l": "chenodeoxycholate + NAD(+) = 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47496", "l": "lithocholate + NADP(+) = 3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}, {"i": "EC:1.1.1.392", "l": "\"3-alpha-hydroxycholanate dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51425", "l": "a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O => ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016210", "l": "naringenin-chalcone synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25135", "l": "phosphate + pyridoxamine = H2O + pyridoxamine 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624112", "l": "CEBPA binds CDK4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16270", "l": "aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP(+) => 4-(dimethylamino)azobenzene + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17591", "l": "H(+) + L-alanine + NADH + pyruvate => 2,2'-iminodipropanoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004413", "l": "homoserine kinase activity"}, {"i": "MetaCyc:HOMOSERKIN-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50369", "l": "2-methylbutan-2-ol + H(+) + NADPH + O2 => 3-hydroxy-3-methylbut-1-ene + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22292", "l": "benzoyl-CoA + 3 H(+) + 3 malonyl-CoA = biphenyl-3,5-diol + 4 CO2 + 4 CoA"}, {"i": "EC:2.3.1.177", "l": "\"3,5-dihydroxybiphenyl synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34947", "l": "(Z)-3-aminoacrylate + H(+) + H2O = 3-oxopropanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23354", "l": "L-glutamate + succinate semialdehyde => 2-oxoglutarate + 4-aminobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684250", "l": "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000120", "l": "CBLIF binds Cbl (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684006", "l": "KPNA2 translocates NBN to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38942", "l": "dioscin + 2 H2O <=> diosgenin 3-O-beta-D-glucoside + 2 L-rhamnopyranose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102488", "l": "dTTP phosphohydrolase activity"}, {"i": "MetaCyc:RXN-14200"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11555", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + H2O <=> 1-O-alkyl-sn-glycerol + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58412", "l": "3 H(+) + hydrogen sulfide + L-aspartate 4-semialdehyde + reduced 2[4Fe-4S]-[ferredoxin] = H2O + L-homocysteine + oxidized 2[4Fe-4S]-[ferredoxin]"}, {"i": "EC:2.8.1.16", "l": "\"L-aspartate semialdehyde sulfurtransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707690", "l": "BACH1 binds MAFK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35031", "l": "L-serine(in) = L-serine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59309", "l": "D-galactono-1,5-lactone + H2O => D-galactonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33237", "l": "3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+) => 2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050439", "l": "2-hydroxy-3-oxoadipate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032441", "l": "pheophorbide a oxygenase activity"}, {"i": "MetaCyc:RXN-7740"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691004", "l": "XPC binds RAD23 and CETN2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706330", "l": "Active FLT3 binds to SOCS6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71050", "l": "Trimerization of the FASL:FAS receptor complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63408", "l": "6-chloropyridine-2,3,5-triol + FADH2 + O2 = 3,6-dihydroxypyridine-2,5-dione + chloride + FAD + 3 H(+) + H2O"}, {"i": "EC:1.14.14.172", "l": "\"3,5,6-trichloropyridin-2-ol monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047584", "l": "4-oxalmesaconate hydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655142", "l": "RCHY1 binds POLH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.19", "l": "\"Prokaryotic ubiquitin-like protein ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10765", "l": "(2R,3S,4S)-leucocyanidin + 2-oxoglutarate + O2 => (4S)-2,3-dehydroleucocyanidin + CO2 + H(+) + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50630", "l": "a 3-(omega-methylsulfanyl)alkylmalate => a 2-(omega-methylsulfanyl)alkylmalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45181", "l": "2 (E)-4-coumaroyl-CoA + spermidine => 2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244503", "l": "botE HC:LC binds SV2A or B and GT1b on the target cell surface (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-349426", "l": "Phosphorylation of MDM4 by CHEK2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381128", "l": "Translation of ATF4  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018811", "l": "cyclohex-1-ene-1-carboxyl-CoA hydratase activity"}, {"i": "MetaCyc:R266-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17074", "l": "acetyl-CoA + cortisol => CoA + cortisol 21-acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35618", "l": "hydroxyacetone + NAD(+) <=> H(+) + methylglyoxal + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030776", "l": "(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity"}, {"i": "RHEA:13005", "l": "(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine = H(+) + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.115", "l": "\"(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220944", "l": "ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32686", "l": "5-hydroxymethylfurfural + 2 H2O + 3 O2 <=> 2,5-dicarboxyfuran + 2 H(+) + 3 H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42635", "l": "adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + 8-methyladenosine(2503) in 23S rRNA + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912627", "l": "CBL ubiquitinates PI3K (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44593", "l": "3-(all-trans-heptaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-heptaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34853", "l": "3-oxoadipyl-CoA + H(+) + NADH => (3S)-3-hydroxyadipyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2197697", "l": "Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166175", "l": "TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15516", "l": "ATP + keto-D-tagatose <=> ADP + H(+) + keto-D-tagatose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14306", "l": "ATP + L-proline + tRNA(Pro) => AMP + diphosphate + L-prolyl-tRNA(Pro)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49170", "l": "8,12-diethyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine => 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018758", "l": "2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine aminohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954056", "l": "E2F6 binds TFDP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23540", "l": "ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)"}, {"i": "EC:6.1.1.17", "l": "\"Glutamate--tRNA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043365", "l": "[formate-C-acetyltransferase]-activating enzyme activity"}, {"i": "MetaCyc:TDCEACT-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000405", "l": "bubble DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47567", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GA2 (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956365", "l": "ZBED1 (DREF) SUMOylates CHD3 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56443", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701557", "l": "AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047123", "l": "quinoline-4-carboxylate 2-oxidoreductase activity"}, {"i": "KEGG.REACTION:R05183"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609739", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2C (GRIN2C) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14092", "l": "2-oxoglutarate + glycine <=> glyoxylate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11623", "l": "H2O + L-2-amino-4-chloropent-4-enoate <=> 2-oxopent-4-enoate + chloride + H(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34607", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-15-methylhexadecasphing-4-enine = a 1,2-diacyl-sn-glycerol + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132284", "l": "Formation of C5b:C6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21899", "l": "(R)-1-aminopropan-2-yl phosphate + adenosylcob(III)yrate + ATP <=> adenosylcob(III)inamide phosphate + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60408", "l": "Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O = Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine] + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061575", "l": "cyclin-dependent protein serine/threonine kinase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21974", "l": "precorrin-2 + S-adenosyl-L-homocysteine => precorrin-1 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72143", "l": "Lariat Formation and 5'-Splice Site Cleavage (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52438", "l": "2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + CoA => a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062072", "l": "H3K9me3 modified histone binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983425", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033990", "l": "ectoine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388596", "l": "Melanocortin receptors bind melanocortins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022870", "l": "protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936951", "l": "Activation of TAK1 complex bound to activated TLR4 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665748", "l": "FMNL2 binds RHOC:GTP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2730835", "l": "Autophosphorylation of PKC-theta (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63218", "l": "7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA => 7-cyano-7-carbaguanosine(15) in tRNA + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093331", "l": "Ras:GTP binds p120-RasGAP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43384", "l": "ATP + L-arginyl-[protein] = ADP + H(+) + N(omega)-phospho-L-arginyl-[protein]"}, {"i": "EC:2.7.14.1", "l": "\"Protein arginine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30534", "l": "biotinate sulfoxide + H(+) + NADH <=> biotin + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38785", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12233", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+) => [thioredoxin]-dithiol + glycine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23919", "l": "H(+) + UDP-alpha-D-glucuronate <=> CO2 + UDP-alpha-D-xylose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48387", "l": "2,3-saturated fatty acid + H2O2 <=> 3-hydroxy fatty acid + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353516", "l": "Ligation of DNA at sites of patch replacement (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38050", "l": "2 [Fe(II)-cytochrome b5] + a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (9Z,12E)-octadecadienoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64198", "l": "a fatty acid + L-lysine => an N-(fatty acyl)-L-lysine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18629", "l": "ATP + NAD(+) = ADP + H(+) + NADP(+)"}, {"i": "EC:2.7.1.23", "l": "\"NAD(+) kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653886", "l": "B4GALT1 binds LALBA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72127", "l": "Formation of the Spliceosomal B Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36844", "l": "(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3238691", "l": "N-linked glycosylation of WNTs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64674", "l": "butyl 2-(methylsulfanyl)acetate + CoA => 2-(methylsulfanyl)acetyl-CoA + butan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950504", "l": "IL27 binds CRLF1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36834", "l": "2 caldariellaquinol + n H(+)(in) + O2 <=> 2 caldariellaquinone + n H(+)(out) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16714", "l": "H2O + S-succinylglutathione => glutathione + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714691", "l": "RAC3 binds ER effectors (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10532", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan"}, {"i": "EC:4.2.1.20", "l": "\"Tryptophan synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41689", "l": "1-O-hexadecyl-2-propanoyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18186", "l": "adenosine + O2 => 5'-dehydroadenosine + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21557", "l": "[calmodulin]-L-lysine + S-adenosyl-L-methionine => [calmodulin]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37060", "l": "adenosine(37) in tRNA + L-threonylcarbamoyladenylate => AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40285", "l": "CoA + O-hexadecanedioyl-L-carnitine => (R)-carnitine + hexadecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18681", "l": "phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine"}, {"i": "EC:2.5.1.7", "l": "\"UDP-N-acetylglucosamine 1-carboxyvinyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26158", "l": "D-glucosone + H(+) + NADPH => D-mannose + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218822", "l": "CRK binds BCAR1 and or PXN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72672", "l": "The 60S subunit joins the translation initiation complex  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49915", "l": "(R)-carnitine(out) + O-propanoyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-propanoyl-(R)-carnitine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22539", "l": "(S)-tetrahydrocolumbamine + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + tetrahydropalmatine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28804", "l": "H2O + L-ascorbate 6-phosphate => 3-dehydro-L-gulonate 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49225", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + reduced [flavodoxin] => dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H(+) + H2O + oxidized [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944255", "l": "Association of procollagen type VII (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446870", "l": "Polyubiquitinated TRAF6 binds the TAK1 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202328", "l": "Translocation of PKC theta to plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14549", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O = 2-oxopent-4-enoate + formate + H(+)"}, {"i": "EC:3.7.1.9", "l": "\"2-hydroxymuconate-6-semialdehyde hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64697", "l": "benzyl alcohol + NAD(+) => benzaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46237", "l": "2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684273", "l": "3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22983", "l": "a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] <=> dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66374", "l": "glycerol + phosphate => H2O + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696358", "l": "TREM,CD300 binds lipids (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16484", "l": "3 S-adenosyl-L-methionine <=> 3 H(+) + nicotianamine + 3 S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50098", "l": "13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031692", "l": "alpha-1B adrenergic receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951500", "l": "Dissociation of CANX from nonameric complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22174", "l": "H(+) + sucrose 6(F)-phosphate + UDP => beta-D-fructose 6-phosphate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56461", "l": "H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37984", "l": "gamma-tocopherol => 2,3-dimethyl-6-phytylbenzene-1,4-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202164", "l": "Translocation of PDK1 to Plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222546", "l": "AP-1 complex stimulates KDM6B transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-264865", "l": "Caspase-mediated cleavage of Lamin A (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29432", "l": "ATP + phosphate => ADP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58925", "l": "(3R,4R)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-4,7-diol => (-)-maackiain + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32721", "l": "(E)-5-(methylsulfanyl)pentanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-dihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15333", "l": "(S)-ureidoglycolate + NADP(+) = H(+) + N-carbamoyl-2-oxoglycine + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6795667", "l": "MDM2 translocates to the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50829", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 => (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E)-docosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665761", "l": "FMNL3 binds RHOC:GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22185", "l": "(+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) => acenaphthene-1,2-dione + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700175", "l": "Active ALK phosphorylates SHC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647680", "l": "CASP1 cleaves GSDMD (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33138", "l": "malonate(in) + Na(+)(in) <=> malonate(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420117", "l": "VEGFR2 autophosphorylates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428749", "l": "Activated TP receptor binds G-proten Gq (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56049", "l": "daidzein + UDP-alpha-D-glucose => daidzein 7-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382054", "l": "PDGF binds to extracellular matrix proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35857", "l": "1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3095901", "l": "ABCC1 transports cytosolic Cbl to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102380", "l": "steviolbioside glucosyltransferase activity (rebaudioside B forming)"}, {"i": "MetaCyc:RXN-13516"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371518", "l": "SIRT1 binds to HSF1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450325", "l": "c-FOS activation by phospho ERK1/2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786070", "l": "IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16488", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazole-4-acetate <=> 1-(5-phosphoribosyl)imidazole-4-acetate + ADP + diphosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.16.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44881", "l": "ATP + L-threonyl-[receptor-protein] => ADP + H(+) + O-phospho-L-threonyl-[receptor-protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.5"}]}
{"type": "biolink:MolecularActivity", "ic": "73.153983691316824", "identifiers": [{"i": "GO:0016822", "l": "hydrolase activity, acting on acid carbon-carbon bonds"}, {"i": "EC:3.7.-.-", "l": "\"Acting on carbon-carbon bonds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12883", "l": "2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + ADP + H(+) => ADP-alpha-D-glucose + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31956", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47168", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+) = 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "73.946956196949927", "identifiers": [{"i": "GO:0016846", "l": "carbon-sulfur lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54985", "l": "a ubiquinol => a ubiquinone + 2 e(-) + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35075", "l": "doxorubicin(in) + H(+)(out) = doxorubicin(out) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-933533", "l": "Dimerization of p-IRF7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50071", "l": "ATP + glycoursodeoxycholate(in) + H2O <=> ADP + glycoursodeoxycholate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60677", "l": "(S)-(-)-citronellol + NAD(+) => (S)-(-)-citronellal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28155", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate => alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75187", "l": "TRAIL:TRAIL receptor trimers bind FADD (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23584", "l": "7,8-dihydropteroate + ATP + L-glutamate = 7,8-dihydrofolate + ADP + H(+) + phosphate"}, {"i": "EC:6.3.2.12", "l": "\"Dihydrofolate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373716", "l": "DCC interacting NCK-1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140062", "l": "5-formylcytosine dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004936", "l": "alpha-adrenergic receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799350", "l": "Exocytosis of specific granule membrane proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58798", "l": "a flavonol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA => a flavonol 7-O-beta-D-glucoside + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9630923", "l": "NFkB inhibitor binds NFkB complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374723", "l": "Nociceptin receptor binds to nociceptin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38754", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39445", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+) => (2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847977", "l": "FRK phosphorylates PTEN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218832", "l": "CDC42:GTP binds PAK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102977", "l": "nitrilotriacetate monooxygenase activity (FMN-dependent)"}]}
{"type": "biolink:MolecularActivity", "ic": "73.153983691316824", "identifiers": [{"i": "GO:0016840", "l": "carbon-nitrogen lyase activity"}, {"i": "EC:4.3.-.-", "l": "\"Carbon-nitrogen lyases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32926", "l": "H2O + sn-glycero-3-phospho-(1'-sn-glycerol) <=> glycerol + H(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52162", "l": "(Z)-phenylacetaldehyde oxime => (E)-phenylacetaldehyde oxime"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37177", "l": "1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.2.2", "l": "\"ABC-type Cd(2+) transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50469", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 27 H(+) + 9 malonyl-CoA + 18 NADPH => 19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 9 H2O + 18 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63164", "l": "H2O + N-tricosanoyl-taurine = taurine + tricosanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0005104", "l": "fibroblast growth factor receptor binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004083", "l": "bisphosphoglycerate 2-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21617", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54135", "l": "a ribonucleoside 5'-diphosphate-alpha-D-glucose + D-glucose 6-phosphate <=> a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166387", "l": "The FA anion diffuses away laterally from UCP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483186", "l": "PC is converted to PS by PTDSS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33687", "l": "3'-N-debenzoyltaxol + benzoyl-CoA = CoA + H(+) + taxol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42159", "l": "3alpha-hydroxy-5alpha-androstan-17-one + H(+) + NADPH <=> 5alpha-androstane-3alpha,17beta-diol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15012", "l": "(6S)-5,6,7,8-tetrahydrofolate + NADP(+) <=> 7,8-dihydrofolate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810724", "l": "PI3 binds the bacterial surface (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9658253", "l": "RAS:GTP binds PI3K (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18950", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha,13alpha-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26267", "l": "dehydroabietate + 2 H(+) + NADPH => dehydroabietadienal + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11564", "l": "4-O-beta-D-glucopyranosyl-D-gluconate + phosphate = alpha-D-glucose 1-phosphate + D-gluconate"}, {"i": "EC:2.4.1.321", "l": "\"Cellobionic acid phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047220", "l": "galactosylxylosylprotein 3-beta-galactosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24638", "l": "H(+) + NADH => H2 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25525", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => 9alpha-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785762", "l": "IL13RA1 binds TYK2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134800", "l": "STING dimerization (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-481007", "l": "Exocytosis of platelet alpha granule contents (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9647994", "l": "RAS proteins are depalmitoylated (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31828", "l": "(2E,6E)-farnesyl diphosphate => (+)-gamma-cadinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29510", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-alpha-gurjunene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60159", "l": "ATP + D-galactose(out) + H2O <=> ADP + D-galactose(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60926", "l": "CO2 + formaldehyde + L-lysyl-[protein] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12714", "l": "a nucleoside 5'-phosphate + ATP => a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73800", "l": "SAICAR => AICAR + Fumarate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944229", "l": "Association of procollagen type IX (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42685", "l": "H2O + L-gamma-glutamyl-hercynylcysteine S-oxide => L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25186", "l": "1,2-dichloroethane + H2O => 2-chloroethanol + chloride + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53317", "l": "GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006332", "l": "JAK2 transphosphorylates and is activated in response to Erythropoietin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10806", "l": "(R)-allantoin => (S)-allantoin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-213407", "l": "Disassociation of PLC-gamma1 from SLP-76 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43937", "l": "androst-5-ene-3,17-dione => androst-4-ene-3,17-dione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381500", "l": "Cathepsin G proteolyzes IGF:IGFBP3:ALS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40429", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49985", "l": "H(+) + jasmonate + NADPH + O2 => (1R,2R)-12-hydroxyjasmonate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52231", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 <=> 3 A + biliverdin beta + CO + Fe(2+) + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114683", "l": "Phosphorylation of Platelet Sec-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37193", "l": "adenosine 2'-phosphate + H(+) => 2',3'-cyclic AMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427337", "l": "MBD2 binds methylcytosine in chromatin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28485", "l": "beta-nicotinamide D-ribonucleotide(in) <=> beta-nicotinamide D-ribonucleotide(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086083", "l": "SUMOylation of ING2 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39621", "l": "(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+) => (2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.35", "l": "\"Dimethylsulfone monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672961", "l": "PP2A dephosphorylates inactive RAFs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14729", "l": "beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate"}, {"i": "EC:4.1.2.13", "l": "\"Fructose-bisphosphate aldolase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015360", "l": "acetate:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805022", "l": "USP2 binds the heterodimer of MDM2 and MDM4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70971", "l": "citrate <=> isocitrate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45607", "l": "D-glucaro-1,4-lactone <=> 5-dehydro-4-deoxy-D-glucarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13822", "l": "2-oxoglutarate + glutarate + O2 => (S)-2-hydroxyglutarate + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031775", "l": "lutropin-choriogonadotropic hormone receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17151", "l": "an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an organic molecule + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10630", "l": "a ribonucleoside 5'-diphosphate + tRNA(n) => phosphate + tRNA(n+1)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936963", "l": "IRAK2 induces TRAF6 oligomerization (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14778", "l": "AMP + H(+) + H2O => IMP + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45806", "l": "ADP + L-glutamine hydroxamate + phosphate => ATP + hydroxylamine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58034", "l": "8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694527", "l": "Loss of SAR1B GTPase (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201639", "l": "Caspase-mediated cleavage of GAS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48925", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM4 (d18:1(4E)) => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17079", "l": "formaldehyde + H2O2 + sarcosine => H2O + N,N-dimethylglycine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209944", "l": "25(OH)D binds GC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686920", "l": "PELI1 ubiquitinates RIPK3 at K363 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56749", "l": "an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31954", "l": "9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-dien-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944218", "l": "Association of procollagen type VIII (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38231", "l": "(9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA = 1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51997", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + O2 + reduced [NADPH--hemoprotein reductase] => a 1-(methylsulfanyl)-4-aci-nitroalkane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45396", "l": "H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55405", "l": "[phosphate](n) + UTP => [phosphate](n+1) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40642", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H2O <=> (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63834", "l": "capsaicin + CoA + H(+) => (6E)-8-methylnon-6-enoyl-CoA + vanillylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25802", "l": "3-acetamidopropanal + H2O2 + spermidine => H2O + N(1)-acetylspermine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64791", "l": "(E)-cinnamate + ATP + CoA <=> (E)-cinnamoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38889", "l": "hexanoate + sphinganine => H2O + N-hexanoyl-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177920", "l": "Binding of GRB2 to GAB1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39993", "l": "CoA + H(+) + N-acyl-4-hydroxyeicosasphinganine => (4R)-hydroxyeicosasphinganine + a fatty acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164832", "l": "ATPase synthesizes ATP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046403", "l": "polynucleotide 3'-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.17"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371537", "l": "DBC1 binds SIRT1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47889", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-873921", "l": "Binding of STAT1 to p-IFNGR1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51235", "l": "2-glyceryl-prostaglandin H2 <=> 2-glyceryl-prostaglandin D2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15009", "l": "(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH"}, {"i": "EC:1.5.1.3", "l": "\"Dihydrofolate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52742", "l": "aminomethylphosphonate + glyoxylate + H(+) + H2O2 => glyphosate + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687097", "l": "p-S857 NCOA3 binds ETV4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63686", "l": "(4R,5S)-dethiobiotin + ADP + H(+) + phosphate => (7R,8S)-8-amino-7-(carboxyamino)nonanoate + ATP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047273", "l": "galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47351", "l": "a butanoate ester + H2O <=> an aliphatic alcohol + butanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31255", "l": "(2S)-2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046987", "l": "N-acetyllactosamine beta-1,3-glucuronosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.58", "l": "\"Caspase-5\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23309", "l": "(E)-sinapoyl-CoA + D-glucarate => 2-O-[(E)-sinapoyl]-D-glucarate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.23.5.-", "l": "\"With a quinone or similar compound as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27538", "l": "ethanol + N,N-dimethyl-4-nitrosoaniline = 4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde"}, {"i": "RHEA:33567", "l": "A + ethanol = acetaldehyde + AH2"}, {"i": "EC:1.1.99.36", "l": "\"Alcohol dehydrogenase (nicotinoprotein)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029453", "l": "Phosphorylation of VAV (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26424", "l": "adenosine 3',5'-bisphosphate + H(+) + thyroxine sulfate => 3'-phosphoadenylyl sulfate + thyroxine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62291", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate <=> (S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043884", "l": "CO-methylating acetyl-CoA synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5658430", "l": "NF1 is degraded by the proteasome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64328", "l": "(7Z)-octadecenoyl-CoA + cholesterol = cholesteryl (7Z)-octadecenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112153", "l": "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429449", "l": "Syk activation leads to SLP-76 activation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20467", "l": "H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP => [hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785165", "l": "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55353", "l": "all-trans-retinol => 13-cis-retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24891", "l": "1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) => 4-hydroxy-L-glutamate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60907", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> 13-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164056", "l": "Dephosphorylation of pChREBP (Ser 568) by PP2A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870466", "l": "RGGT:CHM binds RABs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182988", "l": "Sprouty lures CBL away from EGFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-182986", "l": "CBL-mediated ubiquitination of CIN85 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19479", "l": "3,4-dihydroxybenzoate + H2O + NADP(+) => 4-hydroxybenzoate + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56630", "l": "chloride + 2 H(+) + maleylacetate => 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55409", "l": "[phosphate](n) + CTP => [phosphate](n+1) + CDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19102", "l": "2-butyne-1,4-diol + NAD(+) => 4-hydroxy-2-butynal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19414", "l": "ATP + L-phenylalanine + tRNA(Phe) => AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140061", "l": "5-hydroxymethylcytosine dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110238", "l": "MPG glycosylase mediated recognition and binding of 3-methyladenine  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25966", "l": "benzil + H(+) + NADPH => (R)-benzoin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44709", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38826", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30960", "l": "9,9'-di-cis-zeta-carotene + a quinone => 7,9,9'-tri-cis-neurosporene + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47928", "l": "(S)-3-sulfolactaldehyde + H2O + NADP(+) = (S)-3-sulfolactate + 2 H(+) + NADPH"}, {"i": "RHEA:47932", "l": "(S)-3-sulfolactaldehyde + H2O + NAD(+) = (R)-3-sulfolactate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.97", "l": "\"3-sulfolactaldehyde dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13466", "l": "(S)-2,3-diaminopropanoate + oxalyl-CoA => CoA + N(3)-oxalyl-L-2,3-diaminopropanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51255", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61289", "l": "5-deoxy-D-ribose + ATP => 5-deoxy-alpha-D-ribose 1-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174367", "l": "GCL ligates L-Glu to L-Cys (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56485", "l": "3 O2 + oleanolate + 3 reduced [NADPH--hemoprotein reductase] => gypsogenate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990300", "l": "cellulosome binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198813", "l": "GSTO dimers reduce DeHA to AscH- (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004832", "l": "valine-tRNA ligase activity"}, {"i": "REACT:R-HSA-380199", "l": "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15773", "l": "ATP + dihydroxyacetone = ADP + dihydroxyacetone phosphate + H(+)"}, {"i": "EC:2.7.1.29", "l": "\"Glycerone kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15047", "l": "(R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH => (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001049", "l": "RNA polymerase V core binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65596", "l": "4-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] = 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23825", "l": "(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) => 2,3-dihydroxybenzoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64293", "l": "3,8,9,10-tetrahydroxy-6-methyl-1,4-dihydroanthracen-1-one + H(+) + NADPH => (3R)-3,8,9,10-tetrahydroxy-6-methyl-1,2,3,4-tetrahydroanthracen-1-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12365", "l": "1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) => a quinol + beta-nicotinamide D-riboside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24174", "l": "a 3-oxo-Delta(4)-steroid + AH2 => A + a 3-oxo-5beta-steroid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199518", "l": "C3d-complexed antigen binds to complement receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61855", "l": "campesterol + UDP-alpha-D-glucose <=> campesteryl 3-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10063", "l": "acetyl-CoA + D-tryptophan <=> CoA + H(+) + N-acetyl-D-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195304", "l": "Association of beta-catenin with the destruction complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41900", "l": "H(+) + malonyl-[ACP] + tetradecanoyl-[ACP] = 3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102945", "l": "soyasapogenol B UDP-glucosyl transferase activity"}, {"i": "MetaCyc:RXN-9037"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59504", "l": "cholesterol + glycyl-L-cysteinyl-[protein] + H(+) = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21583", "l": "(2S)-2-acetolactate + H(+) <=> (R)-acetoin + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935960", "l": "RUNX1 binds the TJP1 (ZO-1) gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693347", "l": "HTR1A binds 5HT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15026", "l": "S-adenosyl-L-methionine + xanthosine => 7-methylxanthosine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49952", "l": "(10aS)-10,10a-dihydrophenazine-1-carboxylate = 5,10-dihydrophenazine 1-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244506", "l": "botE HC transports botE LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004149", "l": "dihydrolipoyllysine-residue succinyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48508", "l": "cholate + NADP(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102798", "l": "heptaldehyde:oxygen oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432148", "l": "Fgr may phosphorylate p38 MAPK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36886", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24219", "l": "(2E,6E)-farnesal + H2O + NAD(+) <=> (2E,6E)-farnesoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50135", "l": "ethyl hexadecanoate + H2O <=> ethanol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381727", "l": "RAP1A exchanges GDP for GTP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-482772", "l": "Release of platelet cytosolic components (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55620", "l": "a carotenoid psi-end group = a carotenoid beta-end derivative"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70971", "l": "citrate <=> isocitrate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36309", "l": "3,4-dihydroxybenzaldehyde + acetyl-CoA => (E)-caffeoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-391941", "l": "BLT receptors can bind LTB4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52319", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047939", "l": "L-glucuronate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29818", "l": "ATP + H2O + L-proline(out) <=> ADP + H(+) + L-proline(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65660", "l": "A + calciol + H2O = AH2 + calcidiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25781", "l": "H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine => 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54283", "l": "2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2 <=> (3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48581", "l": "[pyruvate, water dikinase]-phosphate + H(+) + phosphate => [pyruvate, water dikinase] + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371582", "l": "HSBP1 binds HSF1 trimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25788", "l": "4-hydroxy-2-oxoheptanedioate = pyruvate + succinate semialdehyde"}, {"i": "EC:4.1.2.52", "l": "\"4-hydroxy-2-oxoheptanedioate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11753", "l": "acetylsalicylate + H2O => acetate + H(+) + salicylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9016916", "l": "NOTCH3 coactivator complex binds the PTCRA gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3899291", "l": "SUMOylation of EP300 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53844", "l": "glycochenodeoxycholate + NAD(+) = 7-oxoglycolithocholate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874979", "l": "ACBD3 binds GOLGB1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61913", "l": "ATP + H2O + voriconazole(in) => ADP + H(+) + phosphate + voriconazole(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52072", "l": "12-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666435", "l": "VAV1,2,3:PI(3,4,5)P3 binds p-6Y-SYK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660538", "l": "Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33780", "l": "6-kestotriose + sucrose => 6,6-kestotetraose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222093", "l": "BRD7 binds TP53 and EP300 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856189", "l": "TNFSF8 binds TNFRSF8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004449", "l": "isocitrate dehydrogenase (NAD+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14149", "l": "luteolin 7-O-beta-D-glucuronide + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP"}, {"i": "EC:2.4.1.190", "l": "\"Luteolin-7-O-glucuronide 2''-O-glucuronosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.165", "l": "\"Chlorophyllide a 3(1)-hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877391", "l": "FOXP3 in complex with RUNX1 binds intron 1 of the IL2RA (CD25) gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5220959", "l": "TDG excises 5-formylcytosine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420591", "l": "Nectin-2:Nectin 3 trans heterodimer interaction (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679028", "l": "JAK3 binds JAK3 inhibitors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27586", "l": "L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine"}, {"i": "EC:2.6.1.99", "l": "\"L-tryptophan--pyruvate aminotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690023", "l": "NUBPL binds 4Fe-4S (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.33", "l": "\"RCR-type E3 ubiquitin transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10916", "l": "(1R,2R,3R)-prephytoene diphosphate = all-trans-phytoene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23600", "l": "2-oxoglutarate + L-2-aminohexanoate = 2-oxohexanoate + L-glutamate"}, {"i": "EC:2.6.1.67", "l": "\"2-aminohexanoate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653724", "l": "Transcription of ATF5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163602", "l": "2 phosphorylated HSL monomers -> phosphorylated HSL dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27292", "l": "AH2 + CO2 => A + formate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004726", "l": "non-membrane spanning protein tyrosine phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53242", "l": "cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesta-5,7-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64002", "l": "CoA + H(+) + N-octadecanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050299", "l": "streptomycin 3''-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44575", "l": "4-hydroxy-3-all-trans-heptaprenylbenzoate + H(+) <=> 2-all-trans-heptaprenylphenol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43738", "l": "H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine => adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39451", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA = (2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-435244", "l": "PECAM1 is phosphorylated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62816", "l": "4 monapinone E + O2 = 2 dinapinone E + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16292", "l": "(1R,2S)-ephedrine + NAD(+) <=> (R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52948", "l": "deoxycholate + UDP-alpha-D-glucuronate = deoxycholoyl-24-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797554", "l": "ABP1 binds SHANK proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5333678", "l": "CPNEs bind PL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44746", "l": "(3,5-dihydroxyphenyl)acetyl-CoA + 4 CO2 + 3 CoA + H2O => 4 H(+) + 4 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66491", "l": "quillate + UDP-alpha-D-glucose <=> quillaic acid 28-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730858", "l": "Autophosphorylation of BTK/ITK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655826", "l": "Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30717", "l": "(S)-linalool => (2E)-geraniol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5678327", "l": "MIOX oxidises Ins to GlcA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047149", "l": "thetin-homocysteine S-methyltransferase activity"}, {"i": "RHEA:22788", "l": "dimethylsulfonioacetate + L-homocysteine = (methylsulfanyl)acetate + H(+) + L-methionine"}, {"i": "EC:2.1.1.3", "l": "\"Thetin--homocysteine S-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23463", "l": "benzyl cetraxate + H2O <=> benzyl alcohol + cetraxate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66940", "l": "acetyl-CoA + 22 H(+) + 11 malonyl-CoA + 12 NADPH + S-adenosyl-L-methionine = 12 CO2 + 12 CoA + 8 H2O + 12 NADP(+) + S-adenosyl-L-homocysteine + soppiline B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53944", "l": "2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+) = (2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + H(+) + NADPH"}, {"i": "EC:1.3.1.105", "l": "\"2-methylene-furan-3-one reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198611", "l": "AKT phosphorylates IKKalpha (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59451", "l": "dodecan-1-ol + NADP(+) <=> dodecanal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004912", "l": "interleukin-3 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41946", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP => [amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34102", "l": "carboxynorspermidine + H(+) <=> CO2 + norspermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693012", "l": "TNFSF15 binds TNFRSF25 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.35"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22916", "l": "4'-hydroxyacetophenone + H(+) + NADPH + O2 = 4-acetoxyphenol + H2O + NADP(+)"}, {"i": "EC:1.14.13.84", "l": "\"4-hydroxyacetophenone monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1454928", "l": "ABCG4 may mediate cholesterol efflux (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851011", "l": "TRIM27 polyubiquitinates PTEN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23165", "l": "a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose => a flavonol 7-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42230", "l": "AH2 + estrone => 17beta-estradiol + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40790", "l": "H2O + tetracosanoyl-CoA <=> CoA + H(+) + tetracosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72671", "l": "eIF5B:GTP is hydrolyzed and released (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9656893", "l": "OPN1MW binds 11cRAL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140490", "l": "microtubule nucleator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40244", "l": "(3R)-hydroxyhexadecanoyl-CoA + NAD(+) => 3-oxohexadecanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63185", "l": "NADH + 2 O2 => H(+) + NAD(+) + 2 superoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58579", "l": "dihydroprecondylocarpine acetate + NADP(+) <=> H(+) + NADPH + precondylocarpine acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1888198", "l": "FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801776", "l": "REG3A binds bacterial phospholipids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28540", "l": "ADP + H(+) + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430183", "l": "NCK binds PAK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36711", "l": "ATP + H(+) + H2O + O-ureido-D-serine = ADP + CO2 + D-cycloserine + NH4(+) + phosphate"}, {"i": "EC:6.3.3.5", "l": "\"O-ureido-D-serine cyclo-ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-398185", "l": "LARG binds plexin B1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53491", "l": "11beta-hydroxyandrost-4-ene-3,17-dione + H(+) + NADPH <=> 11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40893", "l": "H(+) + hexadecanoate + sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "53.603728191588189", "identifiers": [{"i": "GO:0016788", "l": "hydrolase activity, acting on ester bonds"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605624", "l": "Beta-galactosidase hydrolyses GM1 to GM2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200646", "l": "Cytosolic folate export across the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1028821", "l": "Dimerization of Phospho IRF3 or phospho IRF7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40453", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphate + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44898", "l": "H(+) + N-(2-hydroxyacyl)-beta-D-galactosyl-sphing-4-enine + UDP => a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.74", "l": "\"Long-chain-enoyl-CoA hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18128", "l": "A + a D-alpha-amino acid + H2O <=> a 2-oxocarboxylate + AH2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62487", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45511", "l": "[C-phycoerythrin beta-subunit]-Cys(84)-phycoerythrobilin <=> (2R,3E)-phycoerythrobilin + apo-[C-phycoerythrin beta-subunit]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201634", "l": "Caspase-mediated cleavage of FADK 1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2473594", "l": "Collagen type II degradation by MMP15 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15740", "l": "cyclopentanone + H(+) + NADPH + O2 <=> 5-valerolactone + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709852", "l": "MAVS:TOMM70 recruits HSP90:TBK1:IRF3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43604", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]"}, {"i": "EC:1.17.7.3", "l": "\"(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333671", "l": "CLCAs self cleave (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58815", "l": "ATP + H2O + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate <=> AMP + diphosphate + H(+) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25516", "l": "an acyl-CoA + tropine = CoA + H(+) + O-acyltropine"}, {"i": "EC:2.3.1.185", "l": "\"Tropine acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381608", "l": "cAMP activates EPAC2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869542", "l": "TFPA2A homodimer and NPM1 bind the HSPD1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8873946", "l": "OTUD3 deubiquitinates PTEN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20966", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate => 2-oxoglutarate + L-kynurenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46001", "l": "adenosine + H(+) + tuberculosinyl diphosphate => 1-tuberculosinyladenosine + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848663", "l": "ADIPOQ trimer binds ADIPOR dimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66652", "l": "(2E,6E)-farnesyl diphosphate = african-1-ene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53932", "l": "O2 + prostaglandin I2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-prostaglandin I2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805061", "l": "CK2 binds FACT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16064", "l": "H2O + sn-glycerol 3-phosphocholine <=> choline + H(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25357", "l": "2,6,10,14-tetramethylpentadecanal + formyl-CoA => 2-hydroxyphytanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42073", "l": "(4Z)-2-oxohept-4-enedioate + H2O => (4S)-4-hydroxy-2-oxoheptanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18494", "l": "benzoyl-CoA + glycine => CoA + H(+) + N-benzoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11346", "l": "a CMP-N-acyl-beta-neuraminate + diphosphate => an N-acylneuraminate + CTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21086", "l": "dermatan 4'-sulfate => chondroitin 4'-sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55367", "l": "(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate <=> all-trans-nonaprenyl diphosphate + 6 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61657", "l": "(2E,6E)-farnesol + ATP => (2E,6E)-farnesyl phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265428", "l": "Interaction of integrin alpha9beta1 with VCAM1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983285", "l": "RAD51B binds RAD51C (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111238", "l": "Formation of ADAR2  homodimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990088", "l": "[methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000319", "l": "BORA binds PLK1 and AURKA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56666", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30458", "l": "(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O <=> (-)-geosmin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-197963", "l": "DHFR2 reduces FOLA to DHF (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.3.17", "l": "\"Methylthioalkylmalate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2534096", "l": "METAP1/2 demethylates GNAT1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66696", "l": "(4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + S-adenosyl-L-methionine = (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37072", "l": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine => 2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54794", "l": "[nsP1 protein]-N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidine + diphosphate => [nsP1 protein]-L-histidine + N(7)-methyl-GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62663", "l": "2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol <=> (2'R)-atrovenetin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14863", "l": "H(+) + NADPH + orotate => (S)-dihydroorotate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73932", "l": "Resynthesis of excised residue by POLB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19690", "l": "L-rhamnulose 1-phosphate => (S)-lactaldehyde + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49764", "l": "ethylenediaminetriacetate + FMNH2 + O2 = ethylenediaminediacetate + FMN + glyoxylate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709879", "l": "BIL scavenges O2.- (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50184", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36042", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NAD(+) <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31832", "l": "(2E,6E)-farnesyl diphosphate => delta-guaiene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9716258", "l": "Dimethyl fumarate modifies Cys191 in GSDMD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2672196", "l": "Viral serpin blocks caspase-8 activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20330", "l": "ATP + L-seryl-[low-density-lipoprotein receptor] => ADP + H(+) + O-phospho-L-seryl-[low-density-lipoprotein receptor]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15297", "l": "3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose = 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP"}, {"i": "EC:2.4.1.133", "l": "\"Xylosylprotein 4-beta-galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635461", "l": "PtpA dephosphorylates GSK3A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57832", "l": "5-oxopentanoate + H2O + NADP(+) = glutarate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36330", "l": "ADP + dimethylallyl diphosphate <=> diphosphate + N(6)-(dimethylallyl)adenosine 5'-diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249378", "l": "STING recruits TBK1 and STAT6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58472", "l": "2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + O2 = CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36778", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668481", "l": "Protesomal degradation of K48polyUb-TRAF3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17834", "l": "3-hydroxyanthranilate + S-adenosyl-L-methionine => 3-hydroxy-4-methylanthranilate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0071667", "l": "DNA/RNA hybrid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688294", "l": "SIRT5 deacetylates Cytochrome C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174124", "l": "Dephosphorylation of phospho-Cdh1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694611", "l": "nsp4 is glycosylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14620", "l": "CoA + glutathione + NADP(+) <=> CoA-glutathione + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948709", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625421", "l": "The anterograde IFT train dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948063", "l": "hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647632", "l": "CASP3 cleaves GSDME (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0106359", "l": "2-hydroxyacyl-CoA lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1454916", "l": "The ABCC family mediates organic anion transport (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867047", "l": "PTPN3 dephosphorylates EPS15 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033775", "l": "deoxysarpagine hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41856", "l": "3-oxodecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxydecanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47503", "l": "cholate + NADP(+) <=> 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37336", "l": "5,6-dihydrothymine + H2O => 3-(carbamoylamino)-2-methylpropanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45531", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683831", "l": "CCDC59 binds TTF1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.25", "l": "\"Cucumisin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53877", "l": "a cytidine in tRNA + acetyl-CoA + ATP + H2O => ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389350", "l": "Activation of Cdc42 by pVav1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.37", "l": "\"Gingipain R\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004591", "l": "oxoglutarate dehydrogenase (succinyl-transferring) activity"}, {"i": "MetaCyc:2OXOGLUTDECARB-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879674", "l": "CD97 binds CD55 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41054", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + tetradecanoyl-CoA <=> 1,2-di-(9Z)-octadecenoyl-3-tetradecanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-913675", "l": "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "76.711710297129045", "identifiers": [{"i": "GO:0061733", "l": "peptide-lysine-N-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20605", "l": "cytosine + H(+) + H2O = NH4(+) + uracil"}, {"i": "EC:3.5.4.1", "l": "\"Cytosine deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9617595", "l": "SGTA binds mislocalized membrane protein (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2976742", "l": "NOTCH2 coactivator complex binds FCER2 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031709", "l": "gastrin-releasing peptide receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033783", "l": "25-hydroxycholesterol 7alpha-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158357", "l": "factor XIIa binds SERPING1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27358", "l": "iodide + S-adenosyl-L-methionine => iodomethane + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35771", "l": "5-deoxy-5-amino-3-dehydroshikimate = 3-amino-5-hydroxybenzoate + H(+) + H2O"}, {"i": "EC:4.2.1.144", "l": "\"3-amino-5-hydroxybenzoate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60856", "l": "a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867344", "l": "OMA1 hydrolyses OPA1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186785", "l": "PDGF-AA clevage by Furin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5591086", "l": "SERPINA5 binds activated protein C (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54871", "l": "(2E)-butenoyl-[ACP] + H(+) + NADH <=> butanoyl-[ACP] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692250", "l": "WT1, NR5A1 (SF1), GATA4, ZFPM2 bind the SRY gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944265", "l": "Association of procollagen type IV (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47558", "l": "deoxycholate + taurine => H2O + taurodeoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23450", "l": "CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate => 3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112055", "l": "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052685", "l": "perillic acid-CoA ligase (ADP-forming) activity"}, {"i": "KEGG.REACTION:R06367"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61579", "l": "(4R,5R)-4,5-dihydroxycyclohex-2-ene-1-carbonyl-CoA + NADP(+) <=> (3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53635", "l": "(2E,6E)-farnesyl diphosphate <=> (3S)-(+)-asterisca-2(9),6-diene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63079", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 2-acetylphloroglucinol + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45196", "l": "5,6,7,8-tetrahydrosarcinapterin + [methyl-Co(III) corrinoid Fe-S protein] = 5-methyltetrahydrosarcinapterin + [Co(I) corrinoid Fe-S protein] + H(+)"}, {"i": "EC:2.1.1.245", "l": "\"5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22317", "l": "13-hydroxydocosanoate + UDP-alpha-D-glucose => 13-(beta-D-glucosyloxy)docosanoate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692749", "l": "CDC14A,B bind MAPK6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814298", "l": "Late envelope proteins bind cornified envelope:CDSN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694563", "l": "ABHD10 hydrolyses MPAG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15865", "l": "AH2 + O2 + tryptamine = 4-hydroxytryptamine + A + H2O"}, {"i": "EC:1.14.99.59", "l": "\"Tryptamine 4-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44290", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + CDP-choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42437", "l": "L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein] => L-ascorbate 6-phosphate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.-.-", "l": "\"Carbon-carbon lyases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619669", "l": "L-PRX dimer binds DRP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10205", "l": "dimethylamine + H(+) + H2O + oxidized [electron-transfer flavoprotein] => formaldehyde + methylamine + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66740", "l": "ATP + H2O + N-acetyl-L-glutamate(in) = ADP + H(+) + N-acetyl-L-glutamate(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9612219", "l": "ERBB4s80 binds to SRC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801776", "l": "REG3A binds bacterial phospholipids (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034485", "l": "phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity"}, {"i": "REACT:R-HSA-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805981", "l": "HMGB1 release from cells (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12961", "l": "acetoacetate + butanoyl-CoA = acetoacetyl-CoA + butanoate"}, {"i": "EC:2.8.3.9", "l": "\"Butyrate--acetoacetate CoA-transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376141", "l": "Interaction of ABL with ROBO1:SLIT2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018804", "l": "RAC3 GEFs activate RAC3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61416", "l": "(S)-8-oxocitronellyl enol = cis-trans-nepetalactol"}, {"i": "EC:5.5.1.34", "l": "\"(+)-cis,trans-nepetalactol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65843", "l": "ATP(out) + Mg(2+)(out) + phosphate(in) <=> ATP(in) + Mg(2+)(in) + phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13487", "l": "3-((4-bromophenyl)sulfanyl)-2-oxopropanoate + L-glutamate => 2-oxoglutarate + S-(4-bromophenyl)-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50627", "l": "acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O <=> a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5685953", "l": "SIRT6 deacetylates RBBP8 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031737", "l": "CX3C chemokine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983309", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23789", "l": "acetate + ATP + holo-[citrate lyase ACP] => acetyl-[citrate lyase ACP] + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9656893", "l": "OPN1MW binds 11cRAL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211400", "l": "Anthrax lef cleaves target cell MAP2K3 (MEK3) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382061", "l": "Extracellular processing of novel PDGFs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977224", "l": "Serum amyloid P binds DNA and chromatin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.262", "l": "\"Soyasapogenol glucuronosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19410", "l": "cholate + NAD(+) => 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928619", "l": "PAK1 binds RAC1:GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66223", "l": "asc-omegaC7-CoA + O2 <=> asc-omegaDeltaC7-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047354", "l": "sphingosine cholinephosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-482770", "l": "Release of platelet secretory granule components (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18808", "l": "[DsbA protein]-disulfide + [protein]-dithiol <=> [DsbA protein]-dithiol + [protein]-disulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39842", "l": "a 2,3-diacyl-sn-glycerol + an acyl-CoA <=> a triacyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51411", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050785", "l": "advanced glycation end-product receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38001", "l": "H(+) + plastoquinol-9 + S-adenosyl-L-homocysteine => 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46105", "l": "21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] => corticosterone + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38000", "l": "2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + S-adenosyl-L-methionine => H(+) + plastoquinol-9 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5605147", "l": "Defective CYP1B1 does not 4-hydroxylate EST17b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938371", "l": "RUNX2:CBFB binds the LGALS3 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10119", "l": "6-phospho-D-gluconate + NADP(+) <=> CO2 + D-ribulose 5-phosphate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16816", "l": "H2O + L-kynurenine <=> anthranilate + H(+) + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49752", "l": "2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate = CO2 + 2 H2O + NAD(+) + proviolacein"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109702", "l": "PDPK1 phosphorylates AKT2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70420", "l": "HK1,2,3,GCK phosphorylate Glc to form G6P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57899", "l": "2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2 <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30213", "l": "2 [Fe(II)cytochrome c] + 2 H(+) + 2 nitric oxide => 2 [Fe(III)cytochrome c] + H2O + nitrous oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018528", "l": "iminodiacetate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13825", "l": "GDP-alpha-D-rhamnose + NAD(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0004133", "l": "glycogen debranching enzyme activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-947531", "l": "Molybdenum ion transfer onto molybdopterin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244428", "l": "botA HC transports botA LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799761", "l": "TP53 binds PPP1R13L (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44759", "l": "2-methoxy-6-all-trans-heptaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50238", "l": "17alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + pregnenolone + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30594", "l": "H2O + O2 + tyramine <=> (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25669", "l": "(2E)-geranyl diphosphate <=> beta-pinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19260", "l": "a secondary alcohol + NADP(+) <=> a ketone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54408", "l": "1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56448", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031726", "l": "CCR1 chemokine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683664", "l": "GSK3 phosphorylates Nucleoprotein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19175", "l": "(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) => H(+) + NADH + naphthalene + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25583", "l": "alpha-L-fucose <=> beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50555", "l": "prostaglandin C1 <=> prostaglandin B1"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045330", "l": "aspartyl esterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46441", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + AH2 + O2 => A + a (8E,10E,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55037", "l": "an N,N-dimethylornithine lipid + S-adenosyl-L-methionine => an N,N,N-trimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46585", "l": "1alpha-hydroxyvitamin D2 + O2 + reduced [NADPH--hemoprotein reductase] => 1alpha,25-dihydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28994", "l": "N-acetylneuraminate(in) <=> N-acetylneuraminate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183051", "l": "CBL ubiquitinates Sprouty (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64577", "l": "2 [Fe(III)-cytochrome b5] + NADPH => 2 [Fe(II)-cytochrome b5] + H(+) + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52197", "l": "(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] => 1-aci-nitro-2-(phenyl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33644", "l": "(9Z)-tetradecenoate + ATP + CoA => (9Z)-tetradecenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24030", "l": "carnitine + CO2 + succinate => 2-oxoglutarate + 4-(trimethylamino)butanoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9648089", "l": "NEK6 and NEK7 phosphorylate EML4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213192", "l": "Hemidesmosome formation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603784", "l": "PEX19:class I PMP binds PEX3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806610", "l": "Keratin filament formation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389756", "l": "AKT interacts and phosphorylates Cot (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "69.41073208232514", "identifiers": [{"i": "GO:0030533", "l": "triplet codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37742", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine <=> 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoserine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43145", "l": "adenosine(22) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618407", "l": "NR1H2,3 binds the ARL4C gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418553", "l": "cAMP degradation by Phosphodiesterases (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30537", "l": "biotin + H2O + NADP(+) => biotinate sulfoxide + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63284", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "ic": "75.324974028080362", "identifiers": [{"i": "GO:0016647", "l": "oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor"}, {"i": "EC:1.5.3.-", "l": "\"With oxygen as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39713", "l": "2 H(+) + 2 H2O + 2 oxidized coenzyme F420-(gamma-Glu)(n) => O2 + 2 reduced coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351207", "l": "Spermine  => N-acetylated spermine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1861789", "l": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34165", "l": "(2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+) => hydroquinone + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23968", "l": "(E)-coniferaldehyde + H2O + NAD(+) = (E)-ferulate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21053", "l": "(2S)-2-hydroxypropyl-coenzyme M + NAD(+) => 2-oxopropyl-coenzyme M + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25366", "l": "3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NAD(+) <=> H(+) + momilactone A + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174741", "l": "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10655", "l": "a long-chain fatty aldehyde + H2O + NAD(+) <=> a long-chain fatty acid + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57760", "l": "2 (S)-methylmalonyl-CoA + 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH = C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018768", "l": "RHOU auto-activates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015221", "l": "lipopolysaccharide transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209293", "l": "Phosphorylation of CI by CKIalphaepsilon (CKIalpha/DCO) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30762", "l": "5-methylcytosine + H(+) + H2O <=> NH4(+) + thymine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41250", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 9R-hydroperoxy(5Z,7E,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.122", "l": "\"(S)-8-oxocitronellyl enol synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106343", "l": "glutarate dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48795", "l": "GDP-beta-L-fucose + Lc4Cer <=> alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24195", "l": "(2R,4S)-2,4-diaminopentanoate + H2O + NADP(+) <=> (2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047277", "l": "globoside alpha-N-acetylgalactosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380780", "l": "Activation of Src (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38935", "l": "cyclohexane-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = cyclohex-1-ene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]"}, {"i": "EC:1.3.8.11", "l": "\"Cyclohexane-1-carbonyl-CoA dehydrogenase (electron-transfer flavoprotein)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044378", "l": "non-sequence-specific DNA binding, bending"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-913675", "l": "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61059", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + lochnericine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013488", "l": "HEYL gene expression is stimulated by NOTCH3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52673", "l": "2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate => [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35697", "l": "(2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH => (3S)-versiconol acetate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17411", "l": "(S)-N-methylcoclaurine + H(+) + S-adenosyl-L-homocysteine => (S)-coclaurine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0061980", "l": "regulatory RNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936380", "l": "Interaction of PIN1 with p-IRF3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015080", "l": "silver ion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36706", "l": "(2S,5S)-5-carboxymethylproline + ATP <=> (3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33239", "l": "L-threonine + NAD(+) = aminoacetone + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27644", "l": "adenine + alpha-D-ribose 1-phosphate => adenosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36476", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA => (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37850", "l": "13-dihydrodaunorubicin + H(+) + NADPH + O2 <=> daunorubicin + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23108", "l": "D-arabinono-1,4-lactone + H2O = D-arabinonate + H(+)"}, {"i": "EC:3.1.1.30", "l": "\"D-arabinonolactonase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23177", "l": "acetate + ATP + CoA => acetyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5591052", "l": "PROCR binds Protein C (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55158", "l": "a quinol + S-sulfanylglutathione => a quinone + glutathione + H(+) + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876868", "l": "ECE1 cleaves EDN1(53-90) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30273", "l": "2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O => 2 (3,4-dimethoxyphenyl)methanol + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70420", "l": "HK1,2,3,GCK phosphorylate Glc to form G6P (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5591052", "l": "PROCR binds Protein C (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66862", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate => dimethylallyl diphosphate + 4 isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32814", "l": "benzoate(in) <=> benzoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10331", "l": "an L-glycol + NAD(+) <=> a 2-hydroxycarbonyl + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033927", "l": "glucan 1,4-alpha-maltohexaosidase activity"}, {"i": "MetaCyc:3.2.1.98-RXN"}, {"i": "EC:3.2.1.98", "l": "\"Glucan 1,4-alpha-maltohexaosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373867", "l": "BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55220", "l": "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}, {"i": "EC:1.14.18.9", "l": "\"4-alpha-methylsterol monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49870", "l": "(+)-dehydrodiconiferyl acid ketone + a quinol => (+)-dehydrodiconiferyl acid + a quinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61291", "l": "5-deoxy-D-ribose + ATP <=> 5-deoxy-alpha-D-ribose 1-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20336", "l": "ATP + L-seryl-[acetyl-CoA carboxylase] <=> ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112396", "l": "Separation of elongating transcript from template (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2534240", "l": "HSPG2 (perlecan) degradation by MMP14, MMP15 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63711", "l": "2 [Fe(II)-cytochrome b5] + a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl derivative + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl derivative + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.10", "l": "\"Adenosylcobinamide-phosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381091", "l": "IRE1 dimer autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5612508", "l": "GLI3R binds the PTCH1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202604", "l": "Formation of a heteromeric BMP receptor complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38765", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198621", "l": "AKT phosphorylates caspase-9 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016208", "l": "AMP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22118", "l": "H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] 4'-O-beta-D-glucuronide + UDP => luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65296", "l": "(2R)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52068", "l": "9-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8944457", "l": "MAF1 translocates to the nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13160", "l": "(R)-glycerate + CO2 + NADP(+) <=> 2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5225649", "l": "RBBP7 binds histone H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74987", "l": "TTF-I binds to the Sal Box (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380229", "l": "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1474266", "l": "Formation of collagen fibrils (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41119", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35858", "l": "1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183052", "l": "CBL binds to GRB2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10486", "l": "(E)-ferulate + glycine => H2O + N-feruloylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709547", "l": "ESTG binds ESR2:chaperone complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42012", "l": "cortisol + NAD(+) = 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19327", "l": "H2O + NAD(+) + quinoline-3,4-diol => H(+) + NADH + O2 + quinolin-4-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607746", "l": "PKC-delta is activated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43695", "l": "ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] <=> AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60975", "l": "hexan-1-ol + NAD(+) <=> H(+) + hexanal + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56479", "l": "(5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 <=> (4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19936", "l": "alpha-D-glucose 1-phosphate + H2O <=> D-glucose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18386", "l": "acetone + 2 ATP + 3 H2O + hydrogencarbonate => acetoacetate + 2 AMP + 4 H(+) + 4 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56129", "l": "A + dimethylallyl diphosphate + H2O + nonaflavuxanthin => AH2 + diphosphate + flavuxanthin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20530", "l": "2-cis-(+)-abscisic aldehyde + H2O + O2 => 2-cis-(+)-abscisate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222704", "l": "KatG reduces H2O2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70613", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49074", "l": "dibenzothiophene 5,5-dioxide + 2 FMN + 2 H(+) + 2 H2O => dibenzothiophene + 2 FMNH2 + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641229", "l": "TLE oligomerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48827", "l": "GDP-beta-L-fucose + Lc4Cer <=> a lactoside III(4)-a-Fuc-Lc4Cer + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35725", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + CoA => hexadecanoyl-CoA + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77608", "l": "Binding of A1CF to stem-looped RNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64330", "l": "cholesteryl (7Z)-octadecenoate + CoA => (7Z)-octadecenoyl-CoA + cholesterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14694", "l": "dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32251", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+) = (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16281", "l": "ATP + dihydrostreptomycin 6-phosphate = ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + H(+)"}, {"i": "EC:2.7.1.88", "l": "\"Dihydrostreptomycin-6-phosphate 3'-alpha-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11843", "l": "benzaldehyde + H2O + NAD(+) <=> benzoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56644", "l": "a uridine in mRNA = a pseudouridine in mRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50753", "l": "2 naphthalene-1,2,4,8-tetrol + O2 => 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46810", "l": "[trehalose-6-phosphate synthase]-S-methyl-L-cysteine + H(+) + S-adenosyl-L-homocysteine => [trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375160", "l": "NCAM1 binds to ATP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209738", "l": "VD3 binds GC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48802", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+) => a neolactoside nLc4Cer + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5225649", "l": "RBBP7 binds histone H3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205238", "l": "SHP2 interacts with p-KIT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39069", "l": "acetyl-CoA + hexanedioyl-CoA => 3-oxooctanedioyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33052", "l": "choline + NAD(+) => betaine aldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77094", "l": "Formation of cap binding complex (CBC) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71164", "l": "homogentisate + O2 => maleylacetoacetate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39368", "l": "(2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H(+) + NADPH => (13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351596", "l": "Dopamine translocates to a secretory vesicle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030744", "l": "luteolin O-methyltransferase activity"}, {"i": "RHEA:14589", "l": "luteolin + S-adenosyl-L-methionine = chrysoeriol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938231", "l": "RUNX1:CBFB binds CREBBP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090587", "l": "protein-phosphocysteine-glucosamine phosphotransferase system transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848414", "l": "Activated PTK6 binds CDKN1B (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6789092", "l": "NOX2 generates superoxide anion from oxygen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855161", "l": "I(1,3,4,5,6)P5 transports from the nucleus to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12532", "l": "coenzyme B + methyl-coenzyme M = coenzyme M-coenzyme B heterodisulfide + methane"}, {"i": "EC:2.8.4.1", "l": "\"Coenzyme-B sulfoethylthiotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40985", "l": "(9Z)-octadecenoate + 1,3-dihexadecanoylglycerol + H(+) => 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52272", "l": "(1H-indol-3-yl)-N-methylmethanamine + S-adenosyl-L-methionine = gramine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16832", "l": "an aldehyde + H2O + O2 <=> a carboxylate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48320", "l": "ganglioside GA1 + GDP-beta-L-fucose = ganglioside Fuc-GA1 + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23249", "l": "myo-inositol + S-adenosyl-L-methionine => 1D-4-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48377", "l": "a neolactoside nLc4Cer + GDP-beta-L-fucose => a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-171141", "l": "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55130", "l": "(2E)-5-methylhexenoyl-[ACP] + H2O => (3R)-hydroxy-5-methylhexanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66561", "l": "(R)-noradrenaline + L-glutaminyl-[protein] => 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38010", "l": "6-geranylgeranyl-2-methylbenzene-1,4-diol + S-adenosyl-L-methionine <=> 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388855", "l": "Prolactin-releasing hormone receptor binds PRH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50307", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] <=> 21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62812", "l": "4 monapinone A + O2 = 2 dinapinone A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46740", "l": "cholesta-5,7,24-trien-3beta-ol + H(+) + NADPH = cholesta-5,24-dien-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204824", "l": "Interaction of Tie2 and Ang4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0016781", "l": "phosphotransferase activity, paired acceptors"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199935", "l": "MSK1 activates CREB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030272", "l": "5-formyltetrahydrofolate cyclo-ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170120", "l": "Translocation of Cdc25B to the cytoplasm (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62424", "l": "(E)-caffeoyl-CoA + H2O = 3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196125", "l": "Translocation of isocaproaldehyde from the mitochondrial matrix to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63542", "l": "L-leucine + neurotensin-(1-12) => H2O + neurotensin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24930", "l": "H2O + L-cystine <=> NH4(+) + pyruvate + S-sulfanyl-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29114", "l": "H(+) + NADPH + ubiquinone-8 <=> NADP(+) + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39817", "l": "2-hydroxyoctadecanoate + 2 [Fe(III)-cytochrome b5] + H2O => 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22466", "l": "2 H(+) + H2O + N-hydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase] => L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655483", "l": "USP1 autocleavage (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33775", "l": "a 1,2-diacyl-sn-glycerol + CDP-N,N-dimethylethanolamine = 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20430", "l": "apigenin + S-adenosyl-L-methionine => acacetin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9011543", "l": "DCA binds PDK2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047453", "l": "ATP-dependent NAD(P)H-hydrate dehydratase activity"}, {"i": "MetaCyc:4.2.1.93-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66176", "l": "ATP + H2O + taurochenodeoxycholate 3-sulfate(in) = ADP + H(+) + phosphate + taurochenodeoxycholate 3-sulfate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-481044", "l": "Surface deployment of platelet alpha granule membrane components (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44772", "l": "2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + NADPH + O2 = 2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24116", "l": "(2E)-geranyl diphosphate + H2O = (S)-linalool + diphosphate"}, {"i": "EC:4.2.3.25", "l": "\"S-linalool synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42390", "l": "beta-D-gentiobiosyl crocetin + H(+) + UDP => beta-D-glucosyl crocetin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29606", "l": "benzoyl-CoA + H2O + oxidized 2[4Fe-4S]-[ferredoxin] <=> 4-hydroxybenzoyl-CoA + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783880", "l": "PIPOX oxidises PPCA to P6C (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33245", "l": "(E)-7-(methylsulfanyl)heptanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-tetrahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45886", "l": "4-hydroxy-6-(11-methylheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA => 12-methyloctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.2.13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49958", "l": "H2O2 + phenazine-1-carboxylate => 5,10-dihydrophenazine 1-carboxylate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9016526", "l": "RUNX2-P2 binds RUNX2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004514", "l": "nicotinate-nucleotide diphosphorylase (carboxylating) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879942", "l": "The receptor is activated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55898", "l": "5-chloro-L-tryptophan + FAD + 2 H2O => chloride + FADH2 + L-tryptophan + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60764", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-cinerolone = cinerin II + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696131", "l": "AOC1 deaminates Hist (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187828", "l": "Translocation of p21 to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5433066", "l": "Unknown NAT transfers COCH3 to AFXBO-C, AFNBO-C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085992", "l": "SUMOylation of DAXX with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050373", "l": "UDP-arabinose 4-epimerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37882", "l": "methyl aklanonate <=> aklaviketone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.42"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210943", "l": "pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72143", "l": "Lariat Formation and 5'-Splice Site Cleavage (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004032", "l": "alditol:NADP+ 1-oxidoreductase activity"}, {"i": "EC:1.1.1.21", "l": "\"Aldose reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56671", "l": "7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) <=> 7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13152", "l": "A + H(+) + NADPH <=> AH2 + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44581", "l": "4-hydroxy-3-all-trans-decaprenylbenzoate + H(+) => 2-all-trans-decaprenylphenol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810239", "l": "SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5250930", "l": "B-WICH recruits histone acetyltransferases (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12380", "l": "L-2,4-diaminobutanoate + pyruvate = L-alanine + L-aspartate 4-semialdehyde"}, {"i": "EC:2.6.1.46", "l": "\"Diaminobutyrate--pyruvate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41446", "l": "glycine + 2 H(+) + phosphate => (1R)-(2-amino-1-hydroxyethyl)phosphonate + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003870", "l": "5-aminolevulinate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15170", "l": "H2O + N-succinyl-L-glutamate => L-glutamate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59007", "l": "dodecanal + H2O + O2 <=> dodecanoate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071164", "l": "RNA trimethylguanosine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868071", "l": "Clathrin recruits PIK3C2A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18086", "l": "coenzyme B + coenzyme M + methanophenazine => coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5679205", "l": "ULK1 phosphorylates Beclin-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008721", "l": "D-serine ammonia-lyase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004595", "l": "pantetheine-phosphate adenylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-167427", "l": "Opioid dissociates from MOR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70475", "l": "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41516", "l": "O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase]"}, {"i": "RHEA:41520", "l": "menaquinone-4 + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxymenaquinone-4 + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.78", "l": "\"Phylloquinone omega-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11922", "l": "(6R)-L-erythro-6,7-dihydrobiopterin + H2O => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44468", "l": "3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218832", "l": "CDC42:GTP binds PAK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395992", "l": "p-T,4S-IRF3 is dimerized (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60938", "l": "an (omega-1)-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24675", "l": "ATP + cytidine => ADP + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42937", "l": "S-adenosyl-L-methionine + uridine(32) in tRNA => 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140696", "l": "factor V -> factor Va + factor V activation peptide (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34444", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose => CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168640", "l": "Ubiquitinated IkB is degraded (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50195", "l": "L-seryl-[protein] + UDP-alpha-D-xylose <=> 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781922", "l": "USP13 binds UFD1L:SKP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120285", "l": "tyrosine sensor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015123", "l": "acetate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53562", "l": "18-hydroxy-9,10-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9,10-epoxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21818", "l": "a 2-oxocarboxylate + H2O2 + NH4(+) => a D-alpha-amino acid + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781953", "l": "YOD1 binds VCP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29021", "l": "D-galactose(out) + H(+)(out) => D-galactose(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683925", "l": "ULK1 is dephosphorylated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008820", "l": "cobinamide phosphate guanylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25000", "l": "H(+) + N,N-dihydroxy-L-phenylalanine = (E)-phenylacetaldehyde oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173739", "l": "Spontaneous hydrolysis of C3 thioester (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804762", "l": "TP53 forms homotetramers (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56499", "l": "gypsogenin + O2 + reduced [NADPH--hemoprotein reductase] <=> gypsogenate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952996", "l": "E2F7 forms homodimers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443783", "l": "Interaction of NUMB with L1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57598", "l": "(2S)-2-hydroxyeriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42689", "l": "AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide => A + ergothioneine + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57942", "l": "CO2 + 2 H2O + harderoheme III => Fe-coproporphyrin III + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013009", "l": "RHOA binds effectors at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607747", "l": "TRAF6 binds MALT1 oligomers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247922", "l": "GGCT transforms gGluCys to OPRO (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18103", "l": "3-ethylcatechol + H(+) + NADH => cis-1,2-dihydro-3-ethylcatechol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42886", "l": "(R)-3-phosphomevalonate + ADP + H(+) => (R)-mevalonate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196964", "l": "RFK:Mg2+ phosphorylates RIB (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-425861", "l": "Activation of Protein Kinase C novel isoforms (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56943", "l": "S-methyl-5-thio-D-ribulose 1-phosphate <=> 2-(methylsulfanyl)acetaldehyde + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0030614", "l": "oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor"}, {"i": "EC:1.20.4.-", "l": "\"With disulfide as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35870", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004446", "l": "inositol-hexakisphosphate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120297", "l": "histone dopaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265951", "l": "Phosphorylation of FANCG at S7 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17726", "l": "(2S,3S)-2-methylcitrate => 2-methyl-cis-aconitate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694527", "l": "Loss of SAR1B GTPase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20931", "l": "[DsbA protein]-dithiol + a quinone <=> [DsbA protein]-disulfide + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28271", "l": "acetyl-CoA + spermidine => CoA + H(+) + N(8)-acetylspermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77608", "l": "Binding of A1CF to stem-looped RNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198270", "l": "PDPK1 phosphorylates AKT at T308 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40278", "l": "hexadecanedioyl-CoA + O2 <=> (2E)-hexadecenedioyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45562", "l": "D-allo-isoleucine => L-isoleucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204779", "l": "Interaction of Tie2 with Ang1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2471621", "l": "Endostatin degradation by cathepsins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54652", "l": "peregrinol diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + H2O"}, {"i": "EC:4.2.1.174", "l": "\"Peregrinol diphosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50950", "l": "a 2'-deoxyuridine in single-stranded DNA + NH4(+) => a 2'-deoxycytidine in single-stranded DNA + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58824", "l": "4 H(+) + luteothin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = aureothin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.15.37", "l": "\"Luteothin monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222020", "l": "NUAK1 phosphorylates TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40097", "l": "2 H(+) + hexacosanedioate + NADH => 26-oxohexacosanoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23176", "l": "acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate"}, {"i": "EC:6.2.1.1", "l": "\"Acetate--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49433", "l": "cholate + lithocholoyl-CoA => choloyl-CoA + lithocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928604", "l": "SFKs phosphorylate VAV2,3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203070", "l": "Association of profilin with monomeric actin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810724", "l": "PI3 binds the bacterial surface (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38384", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051871", "l": "dihydrofolic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15357", "l": "5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose = demethyllactenocin + dTDP + H(+)"}, {"i": "EC:2.4.1.317", "l": "\"O-mycaminosyltylonolide 6-deoxyallosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389350", "l": "Activation of Cdc42 by pVav1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44466", "l": "1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14224", "l": "H2O + monomethyl sulfate <=> H(+) + methanol + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70592", "l": "PXLP-K259-GOT1 dimer deaminates L-Asp (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013110", "l": "RHOC binds effectors at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953037", "l": "E2F8 forms homodimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36310", "l": "(E)-caffeoyl-CoA + H2O <=> 3,4-dihydroxybenzaldehyde + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18830", "l": "4-phospho-D-erythronate + NAD(+) => (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6789092", "l": "NOX2 generates superoxide anion from oxygen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54280", "l": "2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2 = (3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30961", "l": "7,9,9'-tri-cis-neurosporene + a quinol => 9,9'-di-cis-zeta-carotene + a quinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5227009", "l": "ABCF1 binds EIF2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35210", "l": "H2O + IDP <=> H(+) + IMP + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0035325", "l": "Toll-like receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16288", "l": "D-octopine + H2O + NAD(+) <=> H(+) + L-arginine + NADH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174731", "l": "Degradation of newly synthesized ApoB-48 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15826", "l": "AZD1979 + H2O => AZD1979 oxetane hydrolysis product + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638006", "l": "ARL3 hydrolyzes GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25676", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015367", "l": "oxoglutarate:malate antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32882", "l": "(1R,4R,5R)-5-hydroxycamphor + NAD(+) <=> (1R,4R)-bornane-2,5-dione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62852", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389532", "l": "PP2A binds CTLA4 dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868340", "l": "CDK5:p25 phosphorylates lamin B1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953398", "l": "PIR oxygenates quercetin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42058", "l": "13-cis-retinal + H(+) + NADH => 13-cis-retinol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784861", "l": "HSPG binds LPL dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5545484", "l": "MLH1 variants-defective DNA mismatch repair (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003711", "l": "transcription elongation regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159795", "l": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052896", "l": "spermidine oxidase (propane-1,3-diamine-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43671", "l": "ATP + hexacosanoyl-CoA + hydrogencarbonate <=> 2-carboxyhexacosanoyl-CoA + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507719", "l": "p62:MEKK3 binds to TRAF6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174119", "l": "Free APC/C phosphorylated by Plk1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43501", "l": "beta-D-glucuronate + NAD(+) => D-glucaro-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62551", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57575", "l": "7-deoxyloganetic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-deoxyloganetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11985", "l": "AH2 + O2 + progesterone => A + H2O + testosterone acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17013", "l": "H(+) + phosphoenolpyruvate = 3-phosphonopyruvate"}, {"i": "EC:5.4.2.9", "l": "\"Phosphoenolpyruvate mutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18329", "l": "(1S,3R,5S)-sabinol + NAD(+) = (1S,5S)-sabinone + H(+) + NADH"}, {"i": "EC:1.1.1.228", "l": "\"(+)-sabinol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58045", "l": "a long-chain fatty acyl-CoA + alpha,alpha-trehalose => 2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10098", "l": "an N-acyl-L-homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine => a fatty acyl-[ACP] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014296", "l": "RAC2 GEFs activate RAC2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11893", "l": "6-O-methylnorlaudanosoline + S-adenosyl-L-methionine => H(+) + nororientaline + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021357", "l": "PRKCI phosphorylates ELF3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50035", "l": "H2O + hexadecanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + hexadecanoyl-4'-phosphopantetheine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-434989", "l": "SEMA7A binds to PLXNC1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51143", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + 2 O2 <=> (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E)-docosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653886", "l": "B4GALT1 binds LALBA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624952", "l": "Assembly of the retrograde IFT train (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32578", "l": "(2E)-geranyl diphosphate <=> (1R,5R)-alpha-pinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607750", "l": "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865994", "l": "GAB1 binds PTPN11 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0016751", "l": "S-succinyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247849", "l": "WLS dissociates from retromer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814409", "l": "CK2 phosphorylates PDCL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2990880", "l": "NEK6/NEK7 phosphorylates NUP98 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26323", "l": "3-methoxyphenol + H(+) + S-adenosyl-L-homocysteine => resorcinol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40424", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16727", "l": "a phosphatidylglycerol + phosphate => a phosphatidylglycerol phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855168", "l": "I(1,3,4,5)P4 transports from the cytosol to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41812", "l": "(2E)-butenoyl-[ACP] + H(+) + NADPH = butanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35312", "l": "3-hydroxyisoheptadecanoyl-CoA + NADP(+) => 3-oxoisoheptadecanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22659", "l": "CDP-ethanolamine + L-serine <=> CMP + H(+) + L-serine-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669158", "l": "NF2 binds PAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3076905", "l": "Extracellular BTD hydrolyses BCTN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2213207", "l": "Formation of collagen networks (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193653", "l": "NGF homodimer binds to p75NTR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2990880", "l": "NEK6/NEK7 phosphorylates NUP98 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28704", "l": "Cu(2+)(in) => Cu(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382553", "l": "ABCA7:Apo1A-mediated phospholipid efflux (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15783", "l": "3-amino-3-(4-hydroxyphenyl)propanoate => L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44980", "l": "(R)-carnitine + butanoyl-CoA = CoA + O-butanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70899", "l": "histidine => urocanate + NH4+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40714", "l": "1-octadecanoylglycerone 3-phosphate + hexadecan-1-ol <=> 1-O-hexadecylglycerone 3-phosphate + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14034", "l": "H2O + sn-glycero-3-phospho-1D-myo-inositol => 1D-myo-inositol 1-phosphate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14236", "l": "a 2-acyl-sn-glycerol 3-phosphate + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421835", "l": "trans-Golgi Network Vesicle Scission (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8963864", "l": "CUBN dissociates from 25(OH)D (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56818", "l": "a pyrimidine nucleobase + D-ribose => a pyrimidine ribonucleoside + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035500", "l": "MH2 domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389026", "l": "Galanin receptors can bind galanin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730903", "l": "Oligomerization of TRAF6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-196753", "l": "2xPPCS ligates PPanK with Cys (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420365", "l": "Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9690494", "l": "RHOB translocates to the endosome membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110244", "l": "Excision of FapyG by OGG1 glycosylase (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60356", "l": "H2O + N-octanoylanthranilate = anthranilate + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66801", "l": "miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + miltiradien-20-al + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60788", "l": "gibberellin A24 + H(+) + O2 = CO2 + gibberellin A9 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56595", "l": "a disubstituted aliphatic (S)-hydroxynitrile <=> a ketone + hydrogen cyanide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44528", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450550", "l": "PKCalpha phosphorylates HuR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080011", "l": "baruol synthase activity"}, {"i": "RHEA:31987", "l": "(S)-2,3-epoxysqualene = baruol"}, {"i": "EC:5.4.99.57", "l": "\"Baruol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036354", "l": "2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a dehydrogenase activity"}, {"i": "RHEA:19733", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+) = bacteriochlorophyllide a + H(+) + NADH"}, {"i": "MetaCyc:RXN-8787"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5615668", "l": "AKR1C3 reduces atRAL to atROL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16217", "l": "H2O + L-arabinono-1,4-lactone = H(+) + L-arabinonate"}, {"i": "EC:3.1.1.15", "l": "\"L-arabinonolactonase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429449", "l": "Syk activation leads to SLP-76 activation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1299318", "l": "Activation of TASK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682967", "l": "WHSC1 binds DNA DSBs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25655", "l": "aminoacetone + CO2 => (2S)-2-amino-3-oxobutanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14910", "l": "L-gulonate + NADP(+) => aldehydo-D-glucuronate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989750", "l": "Expression of FATP1 (SLC27A1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55621", "l": "a carotenoid psi-end group => a carotenoid beta-end derivative"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41775", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) <=> CMP + ganglioside GQ1b (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14214", "l": "ATP + beta-D-fructose 1-phosphate => ADP + beta-D-fructose 1,6-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46832", "l": "4alpha-methyl-5alpha-cholest-8-en-3-one + H(+) + NADPH = 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638046", "l": "ACY3:Zn2+ dimer hydrolyses mercapturic acids (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851988", "l": "BTN2A2 binds T cell surface (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60186", "l": "ADP + D-glucose(in) + H(+) + phosphate => ATP + D-glucose(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196857", "l": "PANK2 phosphorylates PanK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047884", "l": "FAD diphosphatase activity"}, {"i": "MetaCyc:FAD-PYROPHOSPHATASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18007", "l": "D-erythrulose + H(+) + NADPH => D-threitol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66276", "l": "tigogenin + UDP-alpha-D-glucose = H(+) + tigogenin 3-O-beta-D-glucopyranoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18016", "l": "H2O + N(5)-ethyl-L-glutamine <=> ethylamine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28763", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-D-galactose = CoA + dTDP-4-acetamido-4,6-dideoxy-D-galactose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22089", "l": "ATP + GTP => AMP + guanosine 3'-diphosphate 5'-triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50976", "l": "prostaglandin D2(out) = prostaglandin D2(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423694", "l": "AFBDHD hydrolyses non-enzymatically to AFBDHO (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-549129", "l": "OCT1 transports organic cations into hepatic cells (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015264", "l": "methylammonium channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11041", "l": "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate => 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51946", "l": "2 H(+) + roseoflavin + 2 S-adenosyl-L-homocysteine => 8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693558", "l": "Gap-filling DNA synthesis in SDSA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37049", "l": "H(+)(in) + L-histidine(in) => H(+)(out) + L-histidine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59437", "l": "4-amino-L-phenylalanine + ATP + holo-[peptidyl-carrier protein] => 4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48840", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23052", "l": "ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = ADP + H(+) + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]"}, {"i": "EC:2.7.11.2", "l": "\"[Pyruvate dehydrogenase (acetyl-transferring)] kinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047437", "l": "4-oxalocrotonate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2176452", "l": "Degradation of ubiquitinated SMAD2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.39", "l": "\"FMN reductase (NAD(P)H)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807826", "l": "LDHAL6B reduces PYR to LACT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013158", "l": "CDC42 GDIs block activation of CDC42 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799761", "l": "TP53 binds PPP1R13L (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191830", "l": "snRNP nuclear import and release (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1605624", "l": "Beta-galactosidase hydrolyses GM1 to GM2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9652264", "l": "ERBB2 binds TKIs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.3.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12510", "l": "loganin + S-adenosyl-L-homocysteine => loganate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14004", "l": "choloyl-CoA + glycine <=> CoA + glycocholate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19332", "l": "nuatigenin + UDP-alpha-D-glucose <=> H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391211", "l": "Trace amine-associated receptors can bind trace amines (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23984", "l": "cholesterol + NADP(+) = cholesta-5,7-dien-3beta-ol + H(+) + NADPH"}, {"i": "EC:1.3.1.21", "l": "\"7-dehydrocholesterol reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799350", "l": "Exocytosis of specific granule membrane proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617179", "l": "PRKACA phosphorylates TNNI3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17004", "l": "amidinoproclavaminate + H2O <=> proclavaminate + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39857", "l": "a triacyl-sn-glycerol + glycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57696", "l": "ATP + cob(I)inamide--[corrinoid adenosyltransferase] = adenosylcob(III)inamide + apo-[corrinoid adenosyltransferase] + triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59907", "l": "H2O + NADP(+) + octanal <=> 2 H(+) + NADPH + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45620", "l": "H2O + N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-butanoyl ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39727", "l": "a sphingomyelin(in) = a sphingomyelin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19169", "l": "L-serine = NH4(+) + pyruvate"}, {"i": "EC:4.3.1.17", "l": "\"L-serine ammonia-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34114", "l": "carboxyspermidine + H2O + NADP(+) <=> H(+) + L-aspartate 4-semialdehyde + NADPH + putrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58772", "l": "1-O-hexadecyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-O-hexadecyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32605", "l": "(6E)-8-oxogeraniol + H(+) + NADPH => (6E)-8-hydroxygeraniol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44160", "l": "1D-myo-inositol 6-phosphate + H2O = myo-inositol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49173", "l": "8,12-diethyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine => 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10346", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31014", "l": "(S)-2,3-epoxysqualene <=> camelliol C"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050501", "l": "hyaluronan synthase activity"}, {"i": "REACT:R-HSA-2160851", "l": "HAS1,2,3 mediate the polymerisation of HA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66315", "l": "an alpha-mannosylinositol-1-phosphoceramide + H2O <=> a D-mannosyl-alpha-1->6-inositol-1-phosphate + an N-acyl-sphingoid base + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1449687", "l": "Corticosteroids bind to CBG in blood (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30616", "l": "15-cis-phytoene + 2 A => 2 AH2 + all-trans-zeta-carotene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008703", "l": "5-amino-6-(5-phosphoribosylamino)uracil reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70481", "l": "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047003", "l": "dTDP-6-deoxy-L-talose 4-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40395", "l": "1,2-dihydro-beta-NAD + H(+) + O2 = H2O2 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5195402", "l": "CDK1 phosphorylates LPIN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10207", "l": "dimethylamine + H(+) + H2O + oxidized [electron-transfer flavoprotein] <=> formaldehyde + methylamine + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9005995", "l": "MECP2 binds the SIN3A co-repressor complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791221", "l": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102263", "l": "tRNA-dihydrouridine17 synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64430", "l": "glycyl-L-proline(in) + H(+)(in) => glycyl-L-proline(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609737", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN2D (GRIN2D) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13895", "l": "ADP + AMP + 2 H(+) => H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "53.112080385855521", "identifiers": [{"i": "GO:0016772", "l": "transferase activity, transferring phosphorus-containing groups"}, {"i": "EC:2.7.-.-", "l": "\"Transferring phosphorus-containing groups\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51105", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49728", "l": "2 H(+) + NADPH + 2 O2 + protoviolaceinate = CO2 + 2 H2O + NADP(+) + violacein"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786155", "l": "POLN binds ICL-DNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34055", "l": "festuclavine + NAD(+) = 6,8-dimethyl-6,7-didehydroergoline + H(+) + NADH"}, {"i": "EC:1.5.1.44", "l": "\"Festuclavine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33626", "l": "ATP + CoA + dodecanoate <=> AMP + diphosphate + dodecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52393", "l": "ATP + D-erythronate => 4-phospho-D-erythronate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193808", "l": "5beta-cholestan-3alpha,7alpha,27-triol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66682", "l": "ADP + coproporphyrinogen III(out) + H(+) + phosphate => ATP + coproporphyrinogen III(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807585", "l": "BPI binds LPS on the bacterial surface (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12111", "l": "L-arginyl-[histone] + S-adenosyl-L-methionine <=> H(+) + N(omega)-methyl-L-arginyl-[histone] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40545", "l": "H2O + neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin] => 10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220976", "l": "NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694317", "l": "Nsp3, nsp4, and nsp6 produce replicative organelles (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24287", "l": "L-aspartate 4-semialdehyde + NADP(+) + phosphate <=> 4-phospho-L-aspartate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390649", "l": "CHRM1,3,5 bind acetylcholine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62836", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-176956", "l": "Formation of GINS complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15465", "l": "ATP + sphinganine = ADP + H(+) + sphinganine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651828", "l": "PARG dePARylates PARP1,PARP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665761", "l": "FMNL3 binds RHOC:GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33584", "l": "L-glutamate + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate => 2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41741", "l": "adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine => 2 H(+) + N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26199", "l": "ammeline + NH4(+) => H2O + melamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56790", "l": "cob(II)alamin--[corrinoid adenosyltransferase] => apo-[corrinoid adenosyltransferase] + cob(II)alamin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62921", "l": "1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol => 1alpha,2beta,25-trihydroxycholecalciferol + 3-hydroxypropanal"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018574", "l": "2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199154", "l": "CD200 binds to CD200R (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.-", "l": "\"Oxygenases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190265", "l": "FGFR4 binds to FGF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209200", "l": "HEP is phosphorylated and activated by Phospho TAK1:TAB2 kinase complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050143", "l": "nocardicin-A epimerase activity"}, {"i": "RHEA:22792", "l": "isonocardicin A = nocardicin A"}, {"i": "RHEA:42132", "l": "isonocardicin C = nocardicin C"}, {"i": "EC:5.1.1.14", "l": "\"Nocardicin-A epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109702", "l": "PDPK1 phosphorylates AKT2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60940", "l": "(9Z)-hexadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = (9Z)-16-hydroxyhexadec-9-enoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5333051", "l": "RPA1 binds HSF1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25261", "l": "2-hydroxyglutarate + FAD + H(+) = 2-oxoglutarate + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683714", "l": "Unphosphorylated nucleoprotein translocates to the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54839", "l": "H(+) + heptan-2-one + NADPH + O2 <=> H2O + NADP(+) + pentyl acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23257", "l": "adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine => adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928607", "l": "p-EPHs bind VAV2,3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635859", "l": "GLI:SUFU dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211904", "l": "CYP4F12 18-hydroxylates ARA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3928619", "l": "PAK1 binds RAC1:GTP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050541", "l": "beta,beta-carotene-9',10'-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44684", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2399913", "l": "atRAL binds to RBP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139898", "l": "Caspase-8 activates BID by cleavage (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19406", "l": "acetyl-CoA + citrate => (3S)-citryl-CoA + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33791", "l": "H2O + sucrose 6(F)-phosphate = beta-D-fructose + beta-D-glucose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674408", "l": "Regorafenib-resistant PDGFR mutants don't bind regorafenib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700154", "l": "Active ALK binds SHC1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044684", "l": "dihydromethanopterin reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9664879", "l": "ATM:PEX5 binds ATM (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63346", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + ADP + H(+) + phosphate => ATP + L-amino acyl-L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69053", "l": "RFC binding displaces Pol Alpha (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20705", "l": "a D-alpha-amino acid + acetyl-CoA => an N-acetyl-D-amino acid + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59420", "l": "H2O + methylamine + O2 = formaldehyde + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70272", "l": "PGM:Mg2+ isomerise G6P to G1P (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047081", "l": "3-hydroxy-2-methylpyridinecarboxylate dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32379", "l": "(1R,2R,4S)-limonene-1,2-diol + NAD(+) = (1R,4S)-1-hydroxylimonen-2-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19167", "l": "1,2-diacyl-3-O-[alpha-D-glucosyl-(1-> 2)-alpha-D-glucosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-500708", "l": "GRIK3 homomer binds glutamate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41051", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + tetradecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-tetradecanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43317", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46414", "l": "a (7Z,10Z,13Z)-hexadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a (7Z,10Z)-hexadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168921", "l": "TRIF:activated TLR3/TLR4 complex recruits RIP1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19868", "l": "4 H(+) + uroporphyrinogen III <=> 4 CO2 + coproporphyrinogen III"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43357", "l": "cholesteryl (9Z,12Z)-octadecadienoate(in) => cholesteryl (9Z,12Z)-octadecadienoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45996", "l": "a D-alpha-amino acid + a quinone + H2O = a 2-oxocarboxylate + a quinol + NH4(+)"}, {"i": "EC:1.4.5.1", "l": "\"D-amino acid dehydrogenase (quinone)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000247", "l": "Endosomal CBLIF:Cbl translocates to lysosome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047707", "l": "biotin-CoA ligase activity"}, {"i": "MetaCyc:BIOTIN--COA-LIGASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635859", "l": "GLI:SUFU dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199161", "l": "Fc gamma receptors interact with antigen-bound IgG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710354", "l": "GSDME (1-270) binds cardiolipin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662606", "l": "MT3 binds zinc (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50213", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => 11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62405", "l": "(R)-2-hydroxyhexadecanoate + O2 => CO2 + H2O + pentadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4332363", "l": "Autophosphorylation and activation of CAMK2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21178", "l": "5-dehydro-D-gluconate + H(+) + NADPH => L-idonate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55360", "l": "11-cis-retinol = 9-cis-retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40674", "l": "2-iminopropanoate + H2O <=> NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26553", "l": "(S)-piperazine-2-carboxamide + H2O <=> (S)-piperazine-2-carboxylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0032404", "l": "mismatch repair complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177284", "l": "PKA phosphorylates PDE4B (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939201", "l": "ESR dimerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047863", "l": "dimethylallylcistransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9010872", "l": "SLIT2 binds Dystroglycan (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32331", "l": "(1S,2S,4R)-endo-fenchol + NAD(+) = (1S,4R)-fenchone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18464", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193641", "l": "IKK-beta is recruited (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53456", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z-octadecenoate)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39759", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65271", "l": "3-hydroxypentacecilide A + H(+) + NADPH + O2 <=> chrodrimanin F + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797553", "l": "Protein 4.1 binds CASK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4332356", "l": "CAMK2 binds MAP3K7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30853", "l": "D-glyceraldehyde + dihydroxyacetone phosphate => beta-D-fructose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56145", "l": "a quinol + nitrate => a quinone + H2O + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55379", "l": "2 a quinol + O2 <=> 2 a quinone + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37447", "l": "O2 + tetracenomycin F1 = H(+) + H2O + tetracenomycin D3"}, {"i": "EC:1.13.12.21", "l": "\"Tetracenomycin-F1 monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61333", "l": "ATP + H2O + indoxyl sulfate(in) => ADP + H(+) + indoxyl sulfate(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928657", "l": "MMP2,9 cleave EPHB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694338", "l": "nsp1-4 cleaves itself (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004679", "l": "AMP-activated protein kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134962", "l": "DHX36 binds DNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51430", "l": "2-N-acetamidomethylphosphonate + CoA => acetyl-CoA + aminomethylphosphonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229132", "l": "AP4 binds APP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31992", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + sesquithujene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55797", "l": "H(+) + NADH + O2 + phenol => H2O + hydroquinone + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050178", "l": "phenylpyruvate tautomerase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032422", "l": "purine-rich negative regulatory element binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42885", "l": "(R)-mevalonate + ATP => (R)-3-phosphomevalonate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47090", "l": "3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH => (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19126", "l": "glyoxylate + L-serine => 3-hydroxypyruvate + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50458", "l": "prostaglandin D3 => prostaglandin H3"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102292", "l": "30-hydroxy-beta-amyrin 11-hydroxylase activity"}, {"i": "MetaCyc:RXN-12683"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.107"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727819", "l": "TAK1 phosphorylates MKK6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65124", "l": "benzoyl-CoA + ethanol = benzyl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27985", "l": "7-carboxy-7-deazaguanine + ATP + NH4(+) <=> 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22871", "l": "3-chloro-L-alanine + thioglycolate <=> chloride + H(+) + S-carboxymethyl-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35505", "l": "30-hydroxy-11-oxo-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.103", "l": "\"Physarolisin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696547", "l": "STAMBPL1 is a deubiquitinase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19513", "l": "carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate"}, {"i": "EC:2.1.3.3", "l": "\"Ornithine carbamoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14282", "l": "2 [Fe(III)cytochrome c] + H2O + sulfite => 2 [Fe(II)cytochrome c] + 2 H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678920", "l": "TLR processing at low pH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9639698", "l": "ROS positively regulates misfolding of cilia proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9661625", "l": "FVIII is secreted (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670414", "l": "KIT mutants bind SFKs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080031", "l": "methyl salicylate esterase activity"}, {"i": "MetaCyc:RXNQT-4366"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42239", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2468040", "l": "Cohesin binds PDS5 and WAPAL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74747", "l": "Dephosphorylation of p-Y-IRS1,p-Y-IRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-349426", "l": "Phosphorylation of MDM4 by CHEK2 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32185", "l": "cholest-5-en-3-one + H2O2 => cholesterol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28705", "l": "Cu(2+)(out) => Cu(2+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45037", "l": "3 [Fe(III)cytochrome c] + hydroxylamine => 3 [Fe(II)cytochrome c] + 3 H(+) + nitric oxide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051378", "l": "serotonin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018325", "l": "ESR1:ESTG binds CXXC5 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3095889", "l": "MMACHC reduces Cbl (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28808", "l": "glutathione + H2O => L-cysteinylglycine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-933533", "l": "Dimerization of p-IRF7 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36941", "l": "(9Z)-tetradecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59788", "l": "H2O + NAD(+) + pseudopaline = (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098626", "l": "methylseleninic acid reductase activity"}, {"i": "REACT:R-HSA-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43935", "l": "3beta-hydroxyandrost-5-en-17-one + NAD(+) <=> androst-5-ene-3,17-dione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848338", "l": "PNPLA4 hydrolyzes TAG (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013109", "l": "RHOC GEFs activate RHOC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70501", "l": "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60910", "l": "an N(3)-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944266", "l": "Association of procollagen type XI (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15478", "l": "3'-phosphoadenylyl sulfate + 5beta-scymnol => 5beta-scymnol sulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73596", "l": "dCMP + H2O => dUMP + NH4+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.83", "l": "\"Kappa-carrageenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54657", "l": "linalool => (2E)-geraniol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985950", "l": "p-Y649-STAT5A, p-STAT5B dimerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28981", "l": "H(+)(in) + nitrite(out) => H(+)(out) + nitrite(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35257", "l": "ADP + H(+) + lipid A-core(out) + phosphate => ATP + H2O + lipid A-core(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12702", "l": "[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-triphosphate + H2O => [thioredoxin]-dithiol + a ribonucleoside 5'-triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170986", "l": "Ral-GDS binds to Ras-GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37500", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2400009", "l": "PI3K inhibitors block PI3K catalytic activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31231", "l": "4-acetamidobutanal + H2O + NAD(+) = 4-acetamidobutanoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018529", "l": "nitrilotriacetate monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011748", "l": "IL9R binds JAK1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559439", "l": "CD14:LPS binds CR3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202478", "l": "Interaction and oligomerization of MALT1 to Bcl10 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.2.3", "l": "\"Plant seed peroxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008255", "l": "ecdysis-triggering hormone activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24534", "l": "2-methylbut-2-enoyl-CoA + H(+) + NADH => 2-methylbutanoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29149", "l": "2 H(+)(out) + H2O + nitrite + ubiquinone-8 => 2 H(+)(in) + nitrate + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070225", "l": "sulfide dehydrogenase activity"}, {"i": "RHEA:30223", "l": "2 [Fe(III)cytochrome c] + hydrogen sulfide = 2 [Fe(II)cytochrome c] + H(+) + sulfur"}, {"i": "EC:1.8.2.3", "l": "\"Sulfide-cytochrome-c reductase (flavocytochrome c)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350598", "l": "Arginine<=>Agmatine+CO2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60858", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009025", "l": "tagatose-bisphosphate aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26449", "l": "3-oxopropanoate + CoA + NADP(+) <=> H(+) + malonyl-CoA + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005093", "l": "Rab GDP-dissociation inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54734", "l": "H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944219", "l": "Association of procollagen type XVI (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14610", "l": "D-sorbitol + NADP(+) => H(+) + keto-L-sorbose + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56900", "l": "globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine = globoside GlcNAc-(beta1->6)-GalGb4Cer + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55015", "l": "(1S,4R)-1-hydroxylimonen-2-one + NADPH + O2 <=> (3R)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63211", "l": "5-amino-6-(D-ribitylamino)uracil + glyoxal <=> 5-(2-oxoethylideneamino)-6-(D-ribitylamino)uracil + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41715", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H2O <=> a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167235", "l": "Formation of the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26153", "l": "(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil => 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786421", "l": "CHIA hydrolyses chitin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5323526", "l": "FRAT proteins bind GSK3beta (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004105", "l": "choline-phosphate cytidylyltransferase activity"}, {"i": "RHEA:18997", "l": "CTP + H(+) + phosphocholine = CDP-choline + diphosphate"}, {"i": "EC:2.7.7.15", "l": "\"Choline-phosphate cytidylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27999", "l": "H2O + thiamine diphosphate => H(+) + phosphate + thiamine phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66216", "l": "asc-C7-CoA + O2 = asc-DeltaC7-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51856", "l": "(E)-hexadec-2-enoate(out) + ATP(in) + CoA(in) + H(+)(out) = (2E)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58437", "l": "4-methylpentan-1-ol + NADP(+) => 4-methylpentanal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57460", "l": "(E)-sinapoyl alcohol + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-trans-4-sinapoyl alcohol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651773", "l": "LIG1 binds POLB at long-patch BER site (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41885", "l": "dodecanoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54213", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2 => 2-(prostaglandin G2)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203979", "l": "Coat Assembly (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56814", "l": "4-chloro-L-threonyl-[peptidyl-carrier protein] + CO2 + H2O + succinate => 2-oxoglutarate + chloride + H(+) + L-threonyl-[peptidyl-carrier protein] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28855", "l": "H(+)(in) + melibiose(in) = H(+)(out) + melibiose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13198", "l": "H(+) + sulfite + UDP-alpha-D-glucose => H2O + UDP-alpha-D-6-sulfoquinovose"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0004995", "l": "tachykinin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855203", "l": "5-PP-IP5 transports from the nucleus to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218891", "l": "RIPK1:RIPK3 oligomer binds MLKL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694581", "l": "RTC synthesizes SARS-CoV-2 plus strand genomic RNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33231", "l": "H2O2 + heme b = heme d cis-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354077", "l": "Integrin alphaIIb beta3 activation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018861", "l": "4-chlorobenzoate-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225950", "l": "Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854209", "l": "TBC1D10A binds JFC1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814409", "l": "CK2 phosphorylates PDCL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11223", "l": "a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103103", "l": "UDP-glucose: 9-methylthiononylhydroximate S-glucosyltransferase activity"}, {"i": "MetaCyc:RXNQT-4328"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203700", "l": "eNOS translocation from Golgi to Caveolae (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679029", "l": "C-ter TLR7 dimer binds HCQ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58806", "l": "5'-ApG-3' + phosphate => 5'-pApG-3' + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139842", "l": "Binding of Syk tyrosine kinase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13317", "l": "(2R,3R)-tartrate + H(+) = (R)-glycerate + CO2"}, {"i": "EC:4.1.1.73", "l": "\"Tartrate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43788", "l": "acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O = ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate"}, {"i": "EC:2.3.1.193", "l": "\"tRNA(Met) cytidine acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592387", "l": "Fibulin binds elastic fibres (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24241", "l": "A + AMP + 2 H(+) + sulfite => adenosine 5'-phosphosulfate + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5432849", "l": "S100A8:S100A9 binds TLR4:LY96 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20569", "l": "H2O + L-arginine = L-ornithine + urea"}, {"i": "EC:3.5.3.1", "l": "\"Arginase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53175", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphate + ethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35287", "l": "chloramphenicol(in) = chloramphenicol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69116", "l": "Formation of Okazaki fragments (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062148", "l": "L-gamma-glutamyl-L-propargylglycine hydroxylase activity"}, {"i": "RHEA:59900", "l": "2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 = CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46455", "l": "2 L-leucyl-tRNA(Leu) <=> cyclo(L-leucyl-L-leucyl) + 2 H(+) + 2 tRNA(Leu)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44987", "l": "(R)-carnitine + 3-methylbutanoyl-CoA <=> CoA + O-3-methylbutanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848596", "l": "PTK6 binds PXN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11170", "l": "3-oxo-6-carboxyhexanoyl-CoA + H(+) + NADH => 3-hydroxy-6-carboxyhexanoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692408", "l": "NPR2 binds NPPC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24686", "l": "H2O + N-formylmethanofuran = formate + methanofuran"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989762", "l": "Expression of ABCB4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45338", "l": "[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA => (9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16496", "l": "glycerol 1,2-cyclic phosphate + H2O <=> glycerol 1-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44669", "l": "4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol => 4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16383", "l": "H(+) + L-xylulose + NADH => L-arabinitol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54817", "l": "L-glutaminyl-[protein] + L-lysyl-[protein] => [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5195402", "l": "CDK1 phosphorylates LPIN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33278", "l": "a 1,2-diacyl-sn-glycerol + H2O <=> a 2-acylglycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66217", "l": "asc-C7-CoA + O2 => asc-DeltaC7-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247839", "l": "Retromer associates with WLS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848663", "l": "ADIPOQ trimer binds ADIPOR dimers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10383", "l": "diphosphate + orotidine 5'-phosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + orotate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46887", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203567", "l": "palmitoylation of eNOS (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34020", "l": "a 1-acylglycerol + H2O => a fatty acid + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938231", "l": "RUNX1:CBFB binds CREBBP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928640", "l": "PAKs phosphorylate MLC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11326", "l": "all-trans-nonaprenyl diphosphate + diphosphate => all-trans-octaprenyl diphosphate + isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696268", "l": "RND3 binds effectors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63668", "l": "CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+) = (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034786", "l": "9-fluorenone-3,4-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956652", "l": "ITCH gene expression is stimulated by RUNX1 and YAP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112333", "l": "SRC autophosphorylation is positively regulated by InlA-bound CDH1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954117", "l": "E2F6:TFDP1 binds EPC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028583", "l": "Phosphorylation of YAP by LATS2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21662", "l": "benzoate + 2 H(+) + NADPH => benzaldehyde + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34161", "l": "CoA + H(+) + UDP-N,N'-diacetylbacillosamine => acetyl-CoA + UDP-N-acetylbacillosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31690", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60928", "l": "(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 17-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854290", "l": "TBC1D20 binds NS5A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34366", "l": "H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UTP <=> diphosphate + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3785684", "l": "Fibronectin degradation by CTSG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047922", "l": "gentisate 1,2-dioxygenase activity"}, {"i": "RHEA:18237", "l": "2,5-dihydroxybenzoate + O2 = 3-maleylpyruvate + H(+)"}, {"i": "EC:1.13.11.4", "l": "\"Gentisate 1,2-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64682", "l": "CoA + ethyl benzoate => benzoyl-CoA + ethanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417890", "l": "P2Y5 receptor can bind to LPA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34941", "l": "menaquinol-8 + selenate => H2O + menaquinone-8 + selenite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24203", "l": "4-aminobenzoate + H(+) <=> aniline + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047048", "l": "3-hydroxybenzyl-alcohol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806974", "l": "MET dimers autophosphorylate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227769", "l": "TRAF6/or TRAF2 ubiquitination within dsRNA:Mda5:Ips1:Traf6/ or Traf2 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48568", "l": "3-chlorocatechol + O2 = (2E,4Z)-2-chloromuconate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32973", "l": "2 a carboxylate + 2 H(+) + sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63803", "l": "GDP-alpha-D-mannose <=> GDP-beta-L-gulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64178", "l": "(9Z)-octadecenoate + L-tryptophan => H2O + N-(9Z-octadecenoyl)-L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592297", "l": "Full activation of MMP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191636", "l": "Phosphorylation of Cx43 by c-src (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047571", "l": "3-oxosteroid 1-dehydrogenase activity"}, {"i": "MetaCyc:3-OXOSTEROID-1-DEHYDROGENASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30618", "l": "15-cis-phytoene + 2 A <=> 2 AH2 + all-trans-zeta-carotene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948063", "l": "hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64933", "l": "dGTP + 2 H2O => dGMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "77.690207805941611", "identifiers": [{"i": "GO:0016289", "l": "CoA hydrolase activity"}, {"i": "REACT:R-HSA-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56088", "l": "CMP-N-acetyl-beta-neuraminate + globoside MSGG = CMP + globoside DSGG + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31287", "l": "H(+) + oxidized [electron-transfer flavoprotein] + propanoyl-CoA = acryloyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43450", "l": "(2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66877", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 12-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19489", "l": "dibenzothiophene 5,5-dioxide + FMNH2 + O2 = 2'-hydroxybiphenyl-2-sulfinate + FMN-N(5)-oxide + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11335", "l": "ATP + RNA(n) <=> diphosphate + RNA(n)-3'-adenine ribonucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53451", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13073", "l": "guanosine 3'-diphosphate 5'-triphosphate + H2O = guanosine 3',5'-bis(diphosphate) + H(+) + phosphate"}, {"i": "EC:3.6.1.40", "l": "\"Guanosine-5'-triphosphate,3'-diphosphate diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102053", "l": "(-)-jasmonoyl-isoleucine synthetase activity"}, {"i": "MetaCyc:RXN-10435"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917700", "l": "MVB Vesicle Formation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5679239", "l": "ULK complex translocates to the ER (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15103", "l": "CO2 + L-lysine => H(+) + meso-2,6-diaminoheptanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-984689", "l": "Kinesin-7 is a dimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31780", "l": "an all-trans-retinyl ester + H2O => 13-cis-retinol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047205", "l": "quinate O-hydroxycinnamoyltransferase activity"}, {"i": "MetaCyc:2.3.1.99-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030754", "l": "apigenin 4'-O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37844", "l": "1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12569", "l": "4-nitrophenol + H(+) + NADH + O2 => 4-nitrocatechol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672973", "l": "MAP2Ks phosphorylate MAPKs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48025", "l": "1,2,3-tripropanoylglycerol + H2O => dipropanoylglycerol + H(+) + propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31509", "l": "H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate => aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48743", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + O-phospho-L-serine <=> [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55338", "l": "a 3',5'-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine => a 5'-hydroxy-3'-methoxyflavone + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878914", "l": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25249", "l": "H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296045", "l": "Activation of Potassium transport channels (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029456", "l": "RAC1 and CDC42 activate PAK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8939335", "l": "RNF181 polyubiquinates BCL10 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56837", "l": "[PQQ precursor protein] + S-adenosyl-L-methionine => 5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33318", "l": "a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64959", "l": "dTTP + 2 H2O <=> dTMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390438", "l": "FAR2 reduces PalmCoA to HXOL (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14452", "l": "chlorophyllide a + NADP(+) <=> 3,8-divinyl chlorophyllide a + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938108", "l": "SERPINB13 binds cathepsin L (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847912", "l": "PNPLA7 hydrolyzes LysoPtdCho (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46920", "l": "(E)-cinnamate + H(+) = CO2 + styrene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29521", "l": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+) => alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990889", "l": "H4K20me3 modified histone binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10590", "l": "4 CO2 + 4 CoA + 4 H2O + 8 NADP(+) + tetramethylated-mycocerosoyl-[mycocerosate synthase] => 4 (R)-methylmalonyl-CoA + 12 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 8 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852019", "l": "MET bound PI3K generates PIP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16594", "l": "3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine => 3,3',4',5,7-pentahydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034922", "l": "4,5-dihydroxypyrene dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59576", "l": "anserine + H2O = beta-alanine + N(pros)-methyl-L-histidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62010", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+) => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41332", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210444", "l": "L-Glutamate loading of synaptic vesicle (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204364", "l": "ROBO1 binds SLIT2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55932", "l": "3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O = AMP + H(+) + L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44389", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA => 1-heptadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65597", "l": "4-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] => 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693319", "l": "CTRC hydrolyses PRSS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49923", "l": "(R)-carnitine(out) + O-octanoyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-octanoyl-(R)-carnitine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390595", "l": "Calcium Binds Troponin-C (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83677", "l": "C4 deamination of cytidine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37852", "l": "13-deoxydaunorubicin + H(+) + NADPH + O2 => 13-dihydrodaunorubicin + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32647", "l": "erythromycin C + S-adenosyl-L-methionine = erythromycin A + H(+) + S-adenosyl-L-homocysteine"}, {"i": "RHEA:32651", "l": "erythromycin D + S-adenosyl-L-methionine = erythromycin B + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.254", "l": "\"Erythromycin 3''-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50534", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102723", "l": "UDP-glucose:curcumin glucosyltransferase activity"}, {"i": "MetaCyc:RXN-7062"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32104", "l": "2 S-adenosyl-L-methionine + trans-resveratrol => 2 H(+) + pterostilbene + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61888", "l": "diosgenin + UDP-alpha-D-glucose = diosgenin 3-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173626", "l": "Activation of C1r (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2012084", "l": "Constitutive dimerization of FGFR3 cysteine mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32376", "l": "limonene-1,2-diol + NAD(+) => 1-hydroxylimonen-2-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052629", "l": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56968", "l": "dCTP + pyruvate = dCDP + H(+) + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022879", "l": "protein-N(PI)-phosphohistidine-trehalose phosphotransferase system transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187261", "l": "COLEC12 (SCARA4) binds ligands (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0044374", "l": "sequence-specific DNA binding, bending"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686625", "l": "LAIR1 binds collagen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16202", "l": "4-amino-4-deoxychorismate => 4-aminobenzoate + H(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20919", "l": "L-cysteine + sulfite <=> hydrogen sulfide + L-cysteate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55286", "l": "all-trans-retinyl tetradecanoate + CoA => all-trans-retinol + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22959", "l": "1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35238", "l": "H(+)(out) + tetracycline(in) <=> H(+)(in) + tetracycline(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65911", "l": "3-hydroxy-L-kynurenine + pyruvate <=> H2O + L-alanine + xanthurenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.26", "l": "\"2,4-diaminopentanoate dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3204311", "l": "AOX1 oxidises PXL to PDXate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9678854", "l": "S1PR1 binds S1PR1 agonists (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44901", "l": "D-galactono-1,4-lactone + H2O => D-galactonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40647", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2404134", "l": "RBP4:atROL binds TTR (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38680", "l": "ATP + H2O + sphinganine(in) => ADP + H(+) + phosphate + sphinganine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805785", "l": "AKT phosphorylates PHF20 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66945", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + soppiline B => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + soppiline C"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033819", "l": "lipoyl(octanoyl) transferase activity"}, {"i": "REACT:R-HSA-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51604", "l": "2 H(+) + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin] = 4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.15.25", "l": "\"p-cymene methyl-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9615348", "l": "AGT(34-41) binds to AGTR2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38029", "l": "(E)-caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)propanoate => (E)-caffeate + hydrocaffeoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4411373", "l": "NLK translocates to nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050049", "l": "leucine dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.41", "l": "\"Sterol 24-C-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418925", "l": "ADORA2A,B bind Ade-Rib (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11236", "l": "putrescine + spermidine = propane-1,3-diamine + sym-homospermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33776", "l": "a 1,2-diacyl-sn-glycerol + CDP-N,N-dimethylethanolamine => 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55066", "l": "4-methylpentanoate + CoA + H(+) => 4-methylpentanoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53211", "l": "daidzein + O2 + reduced [NADPH--hemoprotein reductase] <=> 2'-hydroxydaidzein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9654533", "l": "KRAS4B recycles to the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47649", "l": "D-ribitol 5-phosphate + H2O => phosphate + ribitol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9617595", "l": "SGTA binds mislocalized membrane protein (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41753", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53448", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3221982", "l": "BANP binds TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5624494", "l": "RAF1 binds p21 RAS:GTP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62515", "l": "2-oxoglutarate + melatonin + O2 <=> 2-hydroxymelatonin + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201521", "l": "ALK autophosphorylation downstream of PTN and MDK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139920", "l": "Translocation of tBID to mitochondria (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56010", "l": "4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) => 4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30452", "l": "(S)-2,3-epoxysqualene => isomultiflorenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70899", "l": "histidine => urocanate + NH4+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2172433", "l": "Collagen type XIX degradation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56633", "l": "H2O + neryl diphosphate => 1,8-cineole + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30263", "l": "H2O2 + 2 L-ascorbate = 2 H2O + 2 monodehydro-L-ascorbate radical"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388831", "l": "Phosphorylation of CD28 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2520883", "l": "Phosphorylated condensin I promotes condensation of prometaphase chromosomes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183055", "l": "Binding of CBL to EGFR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686088", "l": "CASP3 cleaves GSDMD (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58862", "l": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42757", "l": "cytidine(1407) in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(1407) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13388", "l": "3-oxododecanoate + H(+) <=> 2-undecanone + CO2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015350", "l": "methotrexate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61169", "l": "quercetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose => H(+) + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730843", "l": "Phosphorylation of LAT by p-SYK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46620", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol = (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43222", "l": "H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102554", "l": "lipoyl synthase activity (acting on 2-oxoglutarate-dehydrogenase E2 protein"}, {"i": "MetaCyc:RXN-14959"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45834", "l": "3-oxodecanoyl-CoA + H(+) + NADH => (3R)-3-hydroxydecanoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106339", "l": "tRNA (cytidine 32-2'-O)-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50954", "l": "A + CO2 + 2 H2O + monodechloroaminopyrrolnitrin => 7-chloro-L-tryptophan + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61424", "l": "cis-cis-nepetalactol + NAD(+) = cis-cis-nepetalactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34565", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH => CDP-alpha-D-abequose + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102903", "l": "gamma-terpinene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853496", "l": "SCF:FBXL7 binds AURKA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390663", "l": "ADRA2A,B,C bind ADR,NAd (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809707", "l": "MTMR12 binds MTMR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20531", "l": "2-cis-(+)-abscisate + H(+) + H2O2 => 2-cis-(+)-abscisic aldehyde + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51302", "l": "H2O + N-(9Z-octadecenoyl)-L-phenylalanine => (9Z)-octadecenoate + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388814", "l": "Grb2 binds CD28 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003841", "l": "1-acylglycerol-3-phosphate O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65932", "l": "3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + S-adenosyl-L-methionine = 3,5-dimethyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102060", "l": "endo-alpha-bergamotene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20680", "l": "alizarin + UDP-alpha-D-glucose <=> 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197963", "l": "DHFR2 reduces FOLA to DHF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211951", "l": "CYP1B1 4-hydroxylates EST17b (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483186", "l": "PC is converted to PS by PTDSS1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4093331", "l": "Ras:GTP binds p120-RasGAP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10524", "l": "2-oxoglutarate + H(+) = CO2 + succinate semialdehyde"}, {"i": "EC:4.1.1.71", "l": "\"2-oxoglutarate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641134", "l": "SMURF2 binds AXIN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36350", "l": "N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine <=> 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63181", "l": "NADPH + 2 O2 => H(+) + NADP(+) + 2 superoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39774", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201630", "l": "Caspase-mediated cleavage of Acinus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-434650", "l": "MATEs mediate extrusion of xenobiotics (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015532", "l": "alpha-ketoglutarate:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29646", "l": "alpha-maltoheptaose + H2O <=> alpha-D-glucose + alpha-maltohexaose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849102", "l": "SRMS phosphorylates PTK6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001003", "l": "RNA polymerase III type 2 promoter sequence-specific DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60295", "l": "L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684887", "l": "Activation of CHEK1 at resected DNA DSBs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336417", "l": "DT A:B binds HBEGF and CD9 on the target cell surface (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44237", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018814", "l": "RHOT1 hydrolyzes GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17748", "l": "N-acetyl-D-glucosamine + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9612219", "l": "ERBB4s80 binds to SRC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51416", "l": "a (2S,3R)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.2.-", "l": "\"With H(2)O(2) as acceptor, one oxygen atom of which is incorporated into the product\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-981713", "l": "C4b binds to cell surface (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40849", "l": "(2E)-eicosenoyl-CoA + FADH2 => eicosanoyl-CoA + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102313", "l": "1,8-cineole synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48757", "l": "erythritol + NAD(+) => D-erythrulose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68595", "l": "ORC2 binds ORC3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43051", "l": "keto-D-tagatose <=> keto-D-sorbose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211951", "l": "CYP1B1 4-hydroxylates EST17b (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54372", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-(2S,3R,9R)-pristinol + diphosphate"}, {"i": "EC:4.2.3.182", "l": "\"Pristinol synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052814", "l": "medium-chain-aldehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295599", "l": "SPRY2 translocates to the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848818", "l": "PTK6 phosphorylates CBL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23018", "l": "(2R,3R)-dihydrokaempferol + H(+) + NADPH => (2R,3S,4S)-3,4-leucopelargonidin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033295", "l": "hydroxyectoine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8950778", "l": "p-Y693-STAT4 dimerizes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37096", "l": "(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(12Z,15Z,18Z,21Z)-tetracosatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2993802", "l": "HLCS biotinylates PC:Mn2+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37353", "l": "cytidine + phosphate => cytidine 2'-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31491", "l": "soyasaponin III + UDP-beta-L-rhamnose = H(+) + soyasaponin I + UDP"}, {"i": "EC:2.4.1.273", "l": "\"Soyasaponin III rhamnosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007514", "l": "E2F1 binds APAF1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58640", "l": "a 5'-(5'-phospho)-ribonucleoside-RNA + 2 S-adenosyl-L-methionine = a 5'-(5'-bisphosphomethyl)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53787", "l": "beta-muricholate + deoxycholoyl-CoA <=> beta-muricholoyl-CoA + deoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426154", "l": "SREBP1A,2 binds the LSS promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110036", "l": "C2 domain binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008199", "l": "ferric iron binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.75"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58882", "l": "4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212432", "l": "Formation of DRIP coactivator complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15011", "l": "7,8-dihydrofolate + H(+) + NADPH => (6S)-5,6,7,8-tetrahydrofolate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176956", "l": "Formation of GINS complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-199456", "l": "PTEN dephosphorylates PIP3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32528", "l": "N,N'-diacetylchitobiose + phosphate => N-acetyl-alpha-D-glucosamine 1-phosphate + N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10533", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine => D-glyceraldehyde 3-phosphate + H2O + L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55931", "l": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] <=> fenbendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018534", "l": "nitrilotriacetate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40816", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O => (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20559", "l": "CO2 + 2 NH4(+) => 2 H(+) + H2O + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2002460", "l": "P4HB binds Collagen chains (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21851", "l": "(E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide <=> (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373867", "l": "BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11653", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose => alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16535", "l": "H(+) + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + UDP => L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015220", "l": "choline transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61074", "l": "(-)-(R)-19-O-acetyltabersonine + CoA => (-)-(R)-19-hydroxytabersonine + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46530", "l": "(5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65975", "l": "a peptide antigen(in) + ATP + H2O <=> a peptide antigen(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43451", "l": "H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35458", "l": "5alpha-cholest-7-en-3-one + 2 H(+) + 3 NADPH + 3 O2 <=> (25S)-Delta7-dafachronate + 4 H2O + 3 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2169046", "l": "Degradation of TGF-beta receptor complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357429", "l": "AXL autophosphorylates on Y772 and Y814 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863718", "l": "AGFG1 binds VAMP7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30294", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (9S)-hydroperoxy-(10E,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77608", "l": "Binding of A1CF to stem-looped RNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60457", "l": "ATP + UTP => 3',3'-cUAMP + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13098", "l": "a (3R)-hydroxyacyl-[ACP] => a (2E)-enoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21398", "l": "CO2 + Na(+)(out) + propanoyl-CoA => (S)-methylmalonyl-CoA + H(+)(out) + Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944569", "l": "miR-25 microRNA binds PTEN mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810643", "l": "EPPIN protein complex binds bacteria (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9646468", "l": "mTORC1 binds RHEB:GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27871", "l": "(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O => (2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35436", "l": "cyanidin 3-O-beta-D-galactoside + UDP-alpha-D-xylose => cyanidin 3-O-[beta-D-xylosyl-(1->2)-beta-D-galactoside] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30991", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 24-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24007", "l": "butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "ic": "61.029634580571354", "identifiers": [{"i": "GO:0008194", "l": "UDP-glycosyltransferase activity"}, {"i": "REACT:R-HSA-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40432", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661157", "l": "USP9X binds Ub-SNCA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.34"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11632", "l": "AH2 + L-selenocysteine = A + H(+) + hydrogenselenide + L-alanine"}, {"i": "EC:4.4.1.16", "l": "\"Selenocysteine lyase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102824", "l": "UDP-L-rhamnose:quercetin 3-O-rhamnosyltransferase activity"}, {"i": "RHEA:61160", "l": "quercetin + UDP-beta-L-rhamnose = H(+) + quercitrin + UDP"}, {"i": "MetaCyc:RXN-8267"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032405", "l": "MutLalpha complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57349", "l": "3-hydroxy-4-methyl-L-kynurenine + H2O => 3-hydroxy-4-methylanthranilate + H(+) + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684033", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 mRNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12920", "l": "3alpha(S)-strictosidine + H2O <=> D-glucose + strictosidine aglycone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66612", "l": "N(6)-carboxybiotinyl-L-lysyl-[protein] + propanoyl-CoA = methylmalonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67109", "l": "L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23799", "l": "17-O-acetylnorajmaline + H2O <=> acetate + H(+) + norajmaline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686731", "l": "TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34764", "l": "(S,S)-tartrate(out) + succinate(in) => (S,S)-tartrate(in) + succinate(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0008392", "l": "arachidonic acid epoxygenase activity"}, {"i": "REACT:R-HSA-211983", "l": "CYP2J2 oxidises ARA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38496", "l": "a triacylglycerol + H2O => a 1,3-diacylglycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65433", "l": "a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate => a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50679", "l": "H(+) + H2O + N-terminal L-asparaginyl-[protein] <=> N-terminal L-aspartyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70427", "l": "PGM:Mg2+ isomerise G1P to G6P (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10273", "l": "a 1,2-diacyl-sn-glycerol + ATP => a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975853", "l": "Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29093", "l": "a ubiquinol + 4 H(+)(out) + NAD(+) => a ubiquinone + 5 H(+)(in) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944242", "l": "Association of procollagen type XXVII (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22667", "l": "2 1-O-(trans-sinapoyl)-beta-D-glucose <=> 1,2-di-O-sinapoyl beta-D-glucose + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59348", "l": "D-maltobiono-1,5-lactone + H2O = D-maltobionate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35786", "l": "neamine + UDP-alpha-D-kanosamine <=> H(+) + kanamycin B + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295599", "l": "SPRY2 translocates to the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170824", "l": "glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004023", "l": "alcohol dehydrogenase activity, metal ion-independent"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30159", "l": "germacra-1(10),4,11(13)-trien-12-ol + NADP(+) = germacra-1(10),4,11(13)-trien-12-al + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951486", "l": "CD46 binds C4b (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5684882", "l": "CHEK1 is recruited to resected DNA DSBs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46573", "l": "2 H(+) + hexanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 5-hexenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58205", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine => dihydroalstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30758", "l": "ATP + carbamate <=> ADP + carbamoyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878023", "l": "SMAD6 gene expression is stimulated by RUNX2 and SMAD1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9614933", "l": "ACEIs bind ACE (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165055", "l": "Hydrolysis of Ran:GTP to Ran:GDP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102363", "l": "isoscopoletin-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-13475"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681514", "l": "TMPRSS2 binds TMPRSS2 inhibitors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936963", "l": "IRAK2 induces TRAF6 oligomerization (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39511", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA = (2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34409", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate => 3 ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47265", "l": "2,6,10,14-tetramethylpentadecanoate + ATP + CoA => AMP + diphosphate + pristanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784189", "l": "JAKs bind LIFR (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17564", "l": "acetylcholine + H2O <=> acetate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26094", "l": "(4R)-limonene + H(+) + NADH + O2 => H2O + limonene 1,2-epoxide + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33011", "l": "(+)-artemisinic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] = (+)-artemisinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18822", "l": "acetyl-CoA + choline => acetylcholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624130", "l": "Myristoylated NPHP3 translocates into the ciliary membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53038", "l": "4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5225649", "l": "RBBP7 binds histone H3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52154", "l": "indolylmethyl-desulfoglucosinolate + UDP => (E)-2-(1H-indol-3-yl)-1-thioacetohydroximate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45873", "l": "15-hydroxypentadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(14-hydroxytetradecyl)-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64989", "l": "CoA + H2O => adenosine 3',5'-bisphosphate + D-pantetheine 4'-phosphate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76373", "l": "N-hydroxylation of 4-aminobiphenyl (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202722", "l": "CD48 binds CD244 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209061", "l": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63183", "l": "NADPH + 2 O2 <=> H(+) + NADP(+) + 2 superoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51218", "l": "3beta-sulfooxy-androst-5-en-17-one + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444100", "l": "PROT mediates L-proline uptake (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201630", "l": "Caspase-mediated cleavage of Acinus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30973", "l": "all-trans-lycopene => 7,7',9,9'-tetra-cis-lycopene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12742", "l": "ADP + H(+) + H2O => IDP + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0008349", "l": "MAP kinase kinase kinase kinase activity"}, {"i": "REACT:R-HSA-177692", "l": "Activation of recruited TAK1 within the activated TLR3 complex  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109639", "l": "Formation of the closed pre-initiation complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62878", "l": "A + semiviriditoxin => AH2 + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65637", "l": "sphinga-(4E,8E)-dienine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoylsphinga-(4E,8E)-dienine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862300", "l": "LYZ binds bacterial peptidoglycan (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65016", "l": "chlorothalonil + H2O = 4-hydroxychlorothalonil + chloride + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14569", "l": "propane-1,2-diol = H2O + propanal"}, {"i": "EC:4.2.1.28", "l": "\"Propanediol dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444047", "l": "Receptor FFAR3 binds carboxylates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55956", "l": "(9Z)-octadecenoate + AH2 + O2 = (12R)-hydroxy-(9Z)-octadecenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38423", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16808", "l": "2-oxoglutarate + deacetoxycephalosporin C + O2 <=> CO2 + deacetylcephalosporin C + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.29", "l": "\"Pyranose dehydrogenase (acceptor)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32642", "l": "(6E)-8-hydroxylinalool + O2 + reduced [NADPH--hemoprotein reductase] <=> (6E)-8-oxolinalool + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209925", "l": "DIT and MIT combine to form triiodothyronine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-178208", "l": "SMAD7 binds to SMURF2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53854", "l": "7-oxo-glycodeoxycholate + H(+) + NADH => glycocholate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44633", "l": "(3,5-dihydroxyphenyl)acetyl-CoA + O2 => 2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030144", "l": "alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730899", "l": "Oligomerization of BCL10 and MALT1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.36"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610735", "l": "NUMB binds ITCH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5675417", "l": "PEBP1 binds activated RAF1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322429", "l": "XIAP monoubiquinates TLE (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032143", "l": "single thymine insertion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38848", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938913", "l": "RUNX1 binds ELF1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37403", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429730", "l": "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11222", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19201", "l": "2'-deoxyguanosine + ATP = ADP + dGMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0046906", "l": "tetrapyrrole binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354173", "l": "Activation of Rap1 by cytosolic GEFs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5604929", "l": "Activated protein C binds Protein S (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029454", "l": "Autophosphorylation of PAK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23811", "l": "(S)-scoulerine + S-adenosyl-L-methionine <=> (S)-tetrahydrocolumbamine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20474", "l": "(R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] => (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53948", "l": "ATP + holo-[BtrI ACP] + L-glutamate = ADP + gamma-L-glutamyl-[BtrI ACP] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938913", "l": "RUNX1 binds ELF1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390673", "l": "CHRM2,4 bind acetylcholine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218847", "l": "PAK2 binds NCK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23183", "l": "a secondary alcohol + O2 <=> a ketone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029471", "l": "Hydrolysis of PC to PA by PLD (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32571", "l": "(E)-2-methylgeranyl diphosphate + H2O = 2-methylisoborneol + diphosphate"}, {"i": "EC:4.2.3.118", "l": "\"2-methylisoborneol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.202"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327803", "l": "Laminins bind Nidogens 1, 2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157353", "l": "NEXT1 is cleaved to produce NICD1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050125", "l": "N-benzyloxycarbonylglycine hydrolase activity"}, {"i": "KEGG.REACTION:R02551"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799246", "l": "CHEK1 phosphorylates TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873926", "l": "IFNG dimer binds IFNGR (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47297", "l": "dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102560", "l": "5-phospho-alpha-D-ribose 1,2-cyclic phosphate 1-phosphohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048502", "l": "ABC-type thiamine transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12401", "l": "beta-nicotinamide D-ribonucleotide + H2O => NH4(+) + nicotinate beta-D-ribonucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64612", "l": "ATP + L-glutamate + tRNA(Gln) = AMP + diphosphate + L-glutamyl-tRNA(Gln)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35426", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> an anthocyanidin 3,5-di-O-beta-D-glucoside + 2 H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59372", "l": "1-hexadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + 10-hydroxyoctadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30752", "l": "ATP + CoA + hexadecanoate => AMP + diphosphate + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15307", "l": "glycine betaine + 2 H(+) + NADH => betaine aldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41660", "l": "dihydrosanguinarine + NAD(+) = NADH + sanguinarine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47653", "l": "D-ribitol 1-phosphate + H2O => phosphate + ribitol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32689", "l": "diphosphate + tricyclene => (2E)-geranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362450", "l": "Hh processing variants bind lectins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46433", "l": "(25R)-4beta,26-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta,4beta-dihydroxycholest-5-en-26-al + 2 H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47205", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0000257", "l": "nitrilase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018814", "l": "RHOT1 hydrolyzes GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46849", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+) => 5alpha-cholest-8-en-3-one + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62766", "l": "4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38170", "l": "hexadecan-1-ol + hexadecanoyl-CoA <=> CoA + hexadecanyl hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012542", "l": "IL37 binds 2x(CASP1(120-197):CASP1(317-404)) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56681", "l": "beta-dihydromenaquinone-9 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047107", "l": "gamma-guanidinobutyraldehyde dehydrogenase activity"}, {"i": "RHEA:14381", "l": "4-guanidinobutanal + H2O + NAD(+) = 4-guanidinobutanoate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.54", "l": "\"Gamma-guanidinobutyraldehyde dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186785", "l": "PDGF-AA clevage by Furin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40431", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37785", "l": "1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35263", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211466", "l": "HNF1A-dependent synthesis of HNF4A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63569", "l": "beta-casomorphin-7 + H2O => beta-casomorphin-6 + L-isoleucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008177", "l": "RUNX2 binds HEY1,HEY2,HES1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296045", "l": "Activation of Potassium transport channels (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53604", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169406", "l": "ISGylation of host proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65048", "l": "4-acetoxybenzyl alcohol + NAD(+) = 4-acetoxybenzaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59909", "l": "H2O + hexanal + NADP(+) => 2 H(+) + hexanoate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13558", "l": "ATP + glycine + L-gamma-glutamyl-L-cysteine => ADP + glutathione + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693589", "l": "D-loop dissociation and strand annealing (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17170", "l": "acetyl-CoA + alpha-D-galactosamine 1-phosphate => CoA + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60830", "l": "a 5'-end diphospho-adenosine in mRNA + H(+) + phosphate => a 5'-end triphospho-adenosine in mRNA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202510", "l": "Activation of TAK1-TAB2 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "79.682896251205548", "identifiers": [{"i": "GO:0070567", "l": "cytidylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786650", "l": "DDHD1,2 hydrolyse PA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50785", "l": "dodecanal + NADP(+) => (2E)-dodecenal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23887", "l": "nicotinamide + S-adenosyl-L-methionine <=> 1-methylnicotinamide + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675790", "l": "MTORC1 dissociates from ULK complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62578", "l": "ADP + H(+) + L-cystine(in) + phosphate => ATP + H2O + L-cystine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33187", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35937", "l": "2 AMP + brevianamide F + 2 diphosphate + 2 H(+) => 2 ATP + L-proline + L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9035227", "l": "TXN2 binds CysS248-MPST (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2203480", "l": "COLEC11 binds ligands (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21393", "l": "2-phenylacetaldehyde + H2O + NAD(+) => 2-phenylacetate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0005520", "l": "insulin-like growth factor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174171", "l": "Association of Cyclin A with the APC/C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1297333", "l": "Association of Acrosin Heavy and Light Chain (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035401", "l": "histone kinase activity (H3-Y41 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40407", "l": "1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2038944", "l": "Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42231", "l": "17beta-estradiol + A <=> AH2 + estrone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19626", "l": "L-threonine => acetaldehyde + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0080084", "l": "5S rDNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878654", "l": "ACP6 hydrolyses MYS-LPA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39968", "l": "2-aminobut-2-enoate => 2-iminobutanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033443", "l": "AAA codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102938", "l": "orcinol O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24415", "l": "4-(hydroxymethyl)benzenesulfonate + NAD(+) <=> 4-formylbenzenesulfonate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111264", "l": "Addition of nucleotides between position +11 and +30 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19180", "l": "L-lysine <=> (3S)-3,6-diaminohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247847", "l": "WLS is endocytosed to the early endosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14603", "l": "5-aminopentanamide + CO2 + H2O => L-lysine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28340", "l": "crotonobetainyl-CoA + H2O => (R)-carnitinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047099", "l": "CDP-4-dehydro-6-deoxyglucose reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42202", "l": "11-dehydrocorticosterone + H(+) + NADPH => corticosterone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36885", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20224", "l": "(6S)-5,6,7,8-tetrahydrofolate + ATP + formate <=> (6S)-10-formyltetrahydrofolate + ADP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1564120", "l": "Collagen type VII degradation by MMP1,2,3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19382", "l": "(S)-oxalosuccinate + H(+) => 2-oxoglutarate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614605", "l": "Persulfide sulfur is dioxygenated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64542", "l": "a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036487", "l": "nitric-oxide synthase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-481044", "l": "Surface deployment of platelet alpha granule membrane components (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.22", "l": "\"Cyclin-dependent kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1253343", "l": "WWOX binds ERBB4s80 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211874", "l": "CYP2S1 4-hydroxylates atRA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31338", "l": "CTP + H(+) + Mo-molybdopterin <=> diphosphate + Mo-molybdopterin cytosine dinucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18177", "l": "a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl-CoA + H(+) + NADH"}, {"i": "EC:1.3.1.44", "l": "\"Trans-2-enoyl-CoA reductase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209252", "l": "CI75 inhibits transcription (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788611", "l": "HYKK phosphorylates 5HLYS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814096", "l": "ARL1:GTP binds SCOC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864577", "l": "TFAP2C translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990833", "l": "clathrin-uncoating ATPase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25268", "l": "2-phenylethylamine + H2O + O2 <=> 2-phenylacetaldehyde + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35124", "l": "H(+)(out) + L-alanyl-D-glutamate(out) => H(+)(in) + L-alanyl-D-glutamate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12029", "l": "H2O + L-5-carboxymethylhydantoin => H(+) + N-carbamoyl-L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701485", "l": "Active ALK binds JAK3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41091", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.70", "l": "\"Oligopeptidase A\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31630", "l": "10-deoxymethynolide + dTDP-alpha-D-desosamine <=> 10-deoxymethymycin + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61047", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-(R)-19-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034236", "l": "protein kinase A catalytic subunit binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161948", "l": "Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24961", "l": "apo-[aequorin] + 3 Ca(2+) + coelenterazine + O2 => [excited state blue fluorescent protein] + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48281", "l": "ganglioside GM2 + UDP-alpha-D-galactose => ganglioside GM1 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5609939", "l": "Defective PGM1 does not isomerise G6P to G1P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38759", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33383", "l": "(S)-malate + UDP-N-acetyl-alpha-D-glucosamine = (S)-malyl N-acetyl-alpha-D-glucosaminide + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34981", "l": "H(+)(out) => H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730902", "l": "Oligomerization of p-CARMA1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21630", "l": "acetate + androst-4-ene-3,17-dione + H2O + NADP(+) => 17alpha-hydroxyprogesterone + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42608", "l": "a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30111", "l": "Fe(III)-enterobactin + H(+) + 3 H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine"}, {"i": "EC:3.1.1.108", "l": "\"Iron(III) enterobactin esterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028328", "l": "SHC1 bound to activated NTRK2 recruits GRB2:SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700658", "l": "ceritinib-resistant ALK mutants don't bind ceritinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199161", "l": "Fc gamma receptors interact with antigen-bound IgG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373747", "l": "Phosphorylation of nephrin by FYN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37934", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate <=> (10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14072", "l": "D-fructose + NADP(+) <=> 5-dehydro-D-fructose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981809", "l": "ST6GALNAC3/4 can add a sialic acid to the sialyl T antigen to form the disialyl T antigen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58590", "l": "(+)-vincadifformine + acetate + NADP(+) => dihydroprecondylocarpine acetate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65613", "l": "a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] => a 21-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008865", "l": "fructokinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2399913", "l": "atRAL binds to RBP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204779", "l": "Interaction of Tie2 with Ang1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029476", "l": "Role of myosins in phagosome formation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9038052", "l": "GREB1 binds ESR1:ESTG and co-activators (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48930", "l": "CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide => CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684006", "l": "KPNA2 translocates NBN to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622981", "l": "NPY gene expression is stimulated by FOXO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374662", "l": "Translocation of Ezrin to plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33609", "l": "(9Z)-octadecenoyl-CoA + AMP + diphosphate => (9Z)-octadecenoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57693", "l": "2 cob(II)inamide--[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] => 2 cob(I)inamide--[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008481", "l": "sphinganine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21297", "l": "D-galactose + NAD(+) => D-galactono-1,4-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381466", "l": "Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26505", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP-alpha-D-glucose <=> 2 H(+) + ternatin C5 + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.55"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140441", "l": "protein-cysteine S-arachidonoyltransferase activity"}, {"i": "RHEA:59748", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52404", "l": "3-dehydro-4-O-phospho-L-erythronate + H(+) = CO2 + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56756", "l": "5 H(+) + 3 O2 + obtusifoliol + 6 reduced [2Fe-2S]-[ferredoxin] = 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59207", "l": "docosanoyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> AMP + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41649", "l": "aniline + ATP + L-glutamate => ADP + N(5)-phenyl-L-glutamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452701", "l": "Expression of DPPA4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203567", "l": "palmitoylation of eNOS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21912", "l": "CoA + H(+) + O2 + pyruvate = acetyl-CoA + CO2 + H2O2"}, {"i": "EC:1.2.3.6", "l": "\"Pyruvate oxidase (CoA-acetylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52313", "l": "NAD(+) + thromboxane B2 => 11-dehydro-thromboxane B2 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027042", "l": "CPY4 ω-oxidises 14(S)-HDHA to MaR-L1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33213", "l": "2-demethylmenaquinol-7 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-heptaprenyl diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51354", "l": "(9Z)-octadecenoate + L-serine => H2O + N-(9Z-octadecenoyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.6", "l": "\"ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036431", "l": "dCMP kinase activity"}, {"i": "MetaCyc:RXN-11831"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863009", "l": "Influx of extracellular calcium (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11205", "l": "apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin => AMP + diphosphate + H(+) + holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47992", "l": "H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+)"}, {"i": "EC:7.1.1.1", "l": "\"Proton-translocating NAD(P)(+) transhydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-555065", "l": "Formation of clathrin coated vesicle (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212222", "l": "PRC2 recruits DNA methyltransferases (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.-", "l": "\"Sulfotransferases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375395", "l": "C5a receptor binds C5a anaphylatoxin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23423", "l": "alpha,alpha-trehalose 6-phosphate + H2O <=> alpha,alpha-trehalose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390663", "l": "ADRA2A,B,C bind ADR,NAd (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047659", "l": "alpha-santonin 1,2-reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38100", "l": "a ribonucleoside 5'-triphosphate + phytyl phosphate => a ribonucleoside 5'-diphosphate + phytyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27312", "l": "2-hydroxychromene-2-carboxylate + H(+) => naphthalene-1,2-diol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21054", "l": "2-oxopropyl-coenzyme M + H(+) + NADH => (2S)-2-hydroxypropyl-coenzyme M + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46423", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784861", "l": "HSPG binds LPL dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9613497", "l": "Unwinding DNA for the nascent transcript (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11727", "l": "[thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite <=> 3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944397", "l": "p-T69,T71-ATF2 binds PTEN gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213241", "l": "Formation of nonameric complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57626", "l": "3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "78.047734625335977", "identifiers": [{"i": "GO:0005217", "l": "intracellular ligand-gated ion channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209973", "l": "Tyrosine is diiodinated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43217", "l": "(24S)-hydroxycholesterol + 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine => (24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40136", "l": "(9Z)-tetradecenoyl-CoA + H2O => (9Z)-tetradecenoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34666", "l": "20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + S-adenosyl-L-methionine <=> 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35283", "l": "(9Z)-octadecenoyl-CoA = (2E)-octadecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112042", "l": "Opioid binds MOR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052839", "l": "inositol diphosphate tetrakisphosphate kinase activity"}, {"i": "REACT:R-HSA-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Homo sapiens)"}, {"i": "REACT:R-HSA-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22906", "l": "gibberellin A12 aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ent-7alpha-hydroxykaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31585", "l": "2-hydroxy-dAMP + diphosphate + H(+) => 2-hydroxy-dATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62790", "l": "aurasperone B + 2 H2O + NADP(+) => 2 fonsecin B + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65926", "l": "2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine => 2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43211", "l": "carboxymethyluridine(34) in tRNA + S-adenosyl-L-methionine <=> 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46128", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 4beta-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13289", "l": "dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP"}, {"i": "EC:2.7.8.15", "l": "\"UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18765", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = a 1,2-diacyl-sn-glycerol + a sphingomyelin"}, {"i": "EC:2.7.8.27", "l": "\"Sphingomyelin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982617", "l": "CYGB:O2 dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45758", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine => (6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37814", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18659", "l": "3-hydroxypyruvate + H(+) + NADPH => (R)-glycerate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32734", "l": "a diacylglycerol + H2O <=> a fatty acid + a monoacylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62172", "l": "an N-acylethanolamine phosphate + H2O = an N-acylethanolamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665404", "l": "RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106265", "l": "THPH synthase activity"}, {"i": "RHEA:64352", "l": "3 H(+) + hexanoyl-CoA + 3 malonyl-CoA = 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000334", "l": "3-hydroxyanthranilate 3,4-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102341", "l": "3-oxo-lignoceroyl-CoA reductase activity"}, {"i": "MetaCyc:RXN-13300"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40780", "l": "2-aminopentanenitrile + H(+) + 2 H2O => L-2-aminopentanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782419", "l": "TRDMT1 (DNMT2) methylates cytidine-38 of tRNA(Asp) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14423", "l": "4-nitroaniline + H(+) + N(2)-benzoyl-D-arginine => H2O + N(2)-benzoyl-D-arginine-4-nitroanilide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2002440", "l": "Removal of fibrillar collagen C-propeptides (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.3.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70613", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56209", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] => 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857348", "l": "Activated CEBPB stimulates transcription of CDKN2B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30450", "l": "3-methylxanthine + H(+) + NADH + O2 <=> formaldehyde + H2O + NAD(+) + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20365", "l": "phosphoethanolamine + S-adenosyl-L-methionine = H(+) + N-methylethanolamine phosphate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66889", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 8-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74715", "l": "Autophosphorylation of insulin receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14030", "l": "A + H2O + selenite => AH2 + selenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849055", "l": "PTK6 binds ARHGAP35 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005025", "l": "transforming growth factor beta receptor activity, type I"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19323", "l": "formaldehyde + N-methylaniline => N,N-dimethylaniline N-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48250", "l": "CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161673", "l": "PGD2 is dehydrated to 15d-PGD2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28438", "l": "dodecanoyl-(Kdo)2-lipid IVA + tetradecanoyl-[ACP] = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP]"}, {"i": "EC:2.3.1.243", "l": "\"Lauroyl-Kdo(2)-lipid IV(A) myristoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022819", "l": "potassium ion uniporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22869", "l": "3-chloro-L-alanine + thioglycolate => chloride + H(+) + S-carboxymethyl-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225919", "l": "Phospho R-SMAD(SMAD2,3):CO-SMAD(SMAD4):FOXH1 binds Activin Response Element (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102734", "l": "brassinolide synthase activity"}, {"i": "MetaCyc:RXN-720"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26176", "l": "1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine = 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)"}, {"i": "EC:6.3.1.13", "l": "\"L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12601", "l": "2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate"}, {"i": "EC:2.6.1.39", "l": "\"2-aminoadipate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32914", "l": "sn-glycerol 3-phosphocholine(out) <=> sn-glycerol 3-phosphocholine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29288", "l": "2 H(+)(in) + L-aspartate(in) => 2 H(+)(out) + L-aspartate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54246", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0015026", "l": "coreceptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433845", "l": "chicken RIP1 facilitates IKKs complex activation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32366", "l": "L-gulono-1,4-lactone + O2 <=> H(+) + H2O2 + L-ascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2214330", "l": "Cleavage of collagen VII NC2 region by BMP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11703", "l": "H(+) + NADPH + O2 + progesterone <=> H2O + NADP(+) + testosterone acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39614", "l": "3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098641", "l": "cadherin binding involved in cell-cell adhesion"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482772", "l": "Release of platelet cytosolic components (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318576", "l": "Defective MMACHC does not reduce Cbl (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2509831", "l": "ITPA hydrolyses XTP to XMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.388", "l": "\"Glucose-6-phosphate dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109700", "l": "AKT2 binds PIP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.-", "l": "\"With a disulfide as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55542", "l": "40 ADP + 26 H(+) + 3 H2 + 2 NH4(+) + 12 oxidized [2Fe-2S]-[ferredoxin] + 40 phosphate => 40 ATP + 40 H2O + N2 + 12 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2176452", "l": "Degradation of ubiquitinated SMAD2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8963915", "l": "1,25(OH)2D binds VDR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534365", "l": "Slo3 Potassium Transport (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018860", "l": "anthranilate-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199456", "l": "PTEN dephosphorylates PIP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013109", "l": "RHOC GEFs activate RHOC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928578", "l": "EPH receptors autophosphorylate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10758", "l": "AMP + diphosphate + H(+) + phosphoenolpyruvate => ATP + phosphate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448741", "l": "IL22RA2 binds IL22 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696947", "l": "USP47 deubiquitinates POLB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22180", "l": "(S)-norreticuline + S-adenosyl-L-methionine = (S)-norcodamine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56267", "l": "CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> CMP + H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015505", "l": "uracil:cation symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49343", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin <=> 2-hydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507937", "l": "STAT5 dimers translocate to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798353", "l": "E2F7 and E2F8 homo- and heterodimers inhibit E2F1 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176298", "l": "Activation of claspin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64572", "l": "isopentenyl diphosphate + neryl diphosphate = (2Z,6Z)-farnesyl diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63720", "l": "losartan + UDP-alpha-D-glucuronate = losartan-2-N-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603784", "l": "PEX19:class I PMP binds PEX3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.6", "l": "\"Dipeptidyl-dipeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432956", "l": "BP230 is recruited to the hemidesmosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2214330", "l": "Cleavage of collagen VII NC2 region by BMP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12798", "l": "(6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 => CO2 + H(+) + H2O + scopolamine + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63735", "l": "UDP-alpha-D-glucuronate + zolasartan <=> UDP + zolarsartan O-beta-D-glucuronoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.163", "l": "\"1,6-alpha-D-mannosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48219", "l": "H(+) + hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51406", "l": "5-guanidino-2-oxopentanoate + H2O2 + NH4(+) => H2O + L-arginine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944263", "l": "Association of procollagen type II (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65037", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177923", "l": "Sustained activation of SRC kinase by SHP2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3282876", "l": "Defective G6PC3 does not hydrolyze glucose 6-phosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54541", "l": "H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] => beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56511", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61155", "l": "(E)-caffeoyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] <=> CoA + myricetin 3-O-[(6-O-(E)-caffeoyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674019", "l": "BRAP binds KSR1:MARK3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009371", "l": "Binding of AP1 transcriptional activator complexes to CCND1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626928", "l": "CREBBP binds FOXO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38447", "l": "4-O-(beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + H2O = 4-O-(beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose"}, {"i": "EC:3.2.1.187", "l": "\"(Ara-f)(3)-Hyp beta-L-arabinobiosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983138", "l": "Transport of MHC heterotrimer to ER exit site (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27379", "l": "(2R)-2-phosphoglycerate + ADP + H(+) => (R)-glycerate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25247", "l": "(R)-lactate + glutathione + H(+) => (R)-S-lactoylglutathione + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350604", "l": "Agmatine + H2O <=> putrescine + urea (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60615", "l": "1-octanoyl-sn-glycero-3-phosphocholine <=> 1-octanoyl-sn-glycero-2,3-cyclic phosphate + choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55248", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042132", "l": "fructose 1,6-bisphosphate 1-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14542", "l": "choloyl-CoA + H2O => cholate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9639286", "l": "RRAGC,D exchanges GTP for GDP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66235", "l": "IC-asc-C7-CoA + O2 <=> H2O2 + IC-asc-DeltaC7-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474210", "l": "Collagen type III degradation by MMP14 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0016635", "l": "oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor"}, {"i": "EC:1.3.5.-", "l": "\"With a quinone or related compound as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641229", "l": "TLE oligomerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26294", "l": "(1'S,5'S)-averufin + NADPH + O2 => 1'-hydroxyversicolorone + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805285", "l": "PLK3 phosphorylates TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49546", "l": "2-dehydro-3-deoxy-D-gluconate + NH4(+) => (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39386", "l": "3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2032770", "l": "Translocation of YAP1 to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20239", "l": "[(1R)-2,2,3-trimethyl-2-oxocyclopent-3-en-1-yl]acetate + H(+) => (1S,4S)-5-oxo-1,2-campholide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858475", "l": "TNFSF9 binds TNFRSF9 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "60.610786514578848", "identifiers": [{"i": "GO:0008509", "l": "anion transmembrane transporter activity"}, {"i": "REACT:R-HSA-166214", "l": "FA anion flip-flops to the opposite surface (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49437", "l": "cholate + deoxycholoyl-CoA => choloyl-CoA + deoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046180", "l": "KSPG is secreted from the cell (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11212", "l": "indole + O2 = 2-formamidobenzaldehyde"}, {"i": "EC:1.13.11.17", "l": "\"Indole 2,3-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48701", "l": "H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol => a fatty acid + H(+) + long chain acyl-3-O-beta-D-galactosyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249378", "l": "STING recruits TBK1 and STAT6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50034", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + hexadecanoyl-4'-phosphopantetheine => H2O + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25952", "l": "1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde = 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate"}, {"i": "EC:2.2.1.10", "l": "\"2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63026", "l": "(13Z)-docosenoate + NH4(+) => (13Z)-docosenamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19234", "l": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] => H(+) + hexadecanoate + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605768", "l": "Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682388", "l": "Autophagosome maturation (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163090", "l": "Elongation Of The Telomeric Chromosome End (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22692", "l": "3-hydroxybenzoate + H(+) + NADH + O2 = 2,5-dihydroxybenzoate + H2O + NAD(+)"}, {"i": "EC:1.14.13.24", "l": "\"3-hydroxybenzoate 6-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63472", "l": "all-trans-hexaprenol + ATP = ADP + all-trans-hexaprenyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869580", "l": "DEK binds TFAP2A homodimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-744231", "l": "SLC35D2 exchanges UDP-sugars for UMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51433", "l": "(S)-1-aminoethylphosphonate + acetyl-CoA => [(1S)-1-acetamidoethyl]phosphonate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52276", "l": "(6S)-5,6,7,8-tetrahydrofolate + 4-hydroxy-3-methoxybenzoate = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4-dihydroxybenzoate"}, {"i": "RHEA:52280", "l": "(6S)-5,6,7,8-tetrahydrofolate + 3-O-methylgallate = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4,5-trihydroxybenzoate"}, {"i": "EC:2.1.1.341", "l": "\"Vanillate/3-O-methylgallate O-demethylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54503", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> beta-geranylfarnesene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29352", "l": "Zn(2+)(in) => Zn(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.22"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63851", "l": "2 2',3,4-trihydroxy-trans-chalcone + 2 H(+) + O2 <=> 2 3',4'-dihydroxyaurone + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23854", "l": "cis,cis-muconate + 2 H(+) => catechol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928646", "l": "EPHAs bind EFNAs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43114", "l": "H(+) + NADH + phenylglyoxylate => (R)-mandelate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16030", "l": "3-guanidinopropanoate + H2O => beta-alanine + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23784", "l": "a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17076", "l": "acetyl-CoA + cortisol <=> CoA + cortisol 21-acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15097", "l": "5-formimidoyltetrahydrofolate + L-glutamate = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate"}, {"i": "RHEA:23240", "l": "5-formyltetrahydrofolate + L-glutamate = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate"}, {"i": "EC:2.1.2.5", "l": "\"Glutamate formimidoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66387", "l": "(2E,6E,10E,14E)-geranylfarnesol <=> scalar-17(25)-en-19-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114354", "l": "SMAC binds XIAP:Caspase-7 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62426", "l": "3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA => (E)-caffeoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27708", "l": "ADP + D-alanyl-D-serine + H(+) + phosphate => ATP + D-alanine + D-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865090", "l": "UBA6 adenylates ubiquitin in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023846", "l": "Estrogen-responsive CTSD expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36748", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose => beta-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694583", "l": "ABHD4 hydrolyses NAPE (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18790", "l": "D-glucosamine 6-phosphate => D-galactosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51528", "l": "4-hydroxy-3-methoxybenzoate + H(+) = CO2 + guaiacol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419011", "l": "Transhomodimerization of Nectins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35758", "l": "NAD(+) + UDP-alpha-D-glucose <=> H(+) + NADH + UDP-3-oxo-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57506", "l": "pyruvate + succinate => 3-hydroxybutane-1,2,3-tricarboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54390", "l": "2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607737", "l": "BCL10 oligomerizes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434047", "l": "phosphorylation of IRAK2 by activated IRAK4  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54819", "l": "L-glutaminyl-[protein] + L-lysyl-[protein] <=> [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55174", "l": "2-hydroxyhexanoyl-CoA + CO2 + succinate => 2-oxoglutarate + hexanoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31081", "l": "3-methyl-(2E)-butenoyl-CoA + H2O => 3-hydroxyisovaleryl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3200023", "l": "Phosphorylated ETS1 binds p16INK4A promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.66", "l": "\"Thermitase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944457", "l": "MAF1 translocates to the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605724", "l": "Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952069", "l": "HDAC4 deacetylates RUNX3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987214", "l": "p-STAT3 dimerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24763", "l": "H(+) + L-dopa + NADH <=> 3-(3,4-dihydroxyphenyl)propanoate + NAD(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174963", "l": "NAT1 acetylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17171", "l": "CoA + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate => acetyl-CoA + alpha-D-galactosamine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53116", "l": "an 11beta-hydroxysteroid + NAD(+) = an 11-oxosteroid + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858482", "l": "DVL is recruited to the receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4341073", "l": "PIAS3 SUMOylates PGR with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-507873", "l": "Aquaporins passively transport urea out of cells (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28773", "l": "(9Z)-hexadecenoyl-CoA => (2E)-hexadecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990634", "l": "protein phosphatase 5 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40892", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O => H(+) + hexadecanoate + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202216", "l": "Phosphorylation of SLP-76 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63060", "l": "5-methylorsellinate + ATP + H(+) + NADPH = 2,4-dihydroxy 5,6-dimethylbenzaldehyde + AMP + diphosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65236", "l": "3-methylbutanol + acetyl-CoA = 3-methylbutyl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19350", "l": "(R)-4-dehydropantoate + H2O + NAD(+) => (R)-3,3-dimethylmalate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018785", "l": "RHOBTB2 binds GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31216", "l": "(5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+) => (5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32203", "l": "(R)-synephrine = (4-hydroxyphenyl)acetaldehyde + methylamine"}, {"i": "EC:4.2.1.88", "l": "\"Synephrine dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.7.3", "l": "\"Monoterpenyl-diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102616", "l": "oryzalexin A synthase activity"}, {"i": "MetaCyc:RXN-15464"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0008425", "l": "2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867041", "l": "EGFR phosphorylates EPS15 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38655", "l": "6-tuliposide B = D-glucose + tulipalin B"}, {"i": "EC:4.2.99.23", "l": "\"Tuliposide B-converting enzyme\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029453", "l": "Phosphorylation of VAV (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909721", "l": "Translocation of ISGF3 complex to nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16859", "l": "an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine => a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23646", "l": "H(+) + H2O + hyodeoxycholate + oxidized [NADPH--hemoprotein reductase] => lithocholate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15108", "l": "kaempferol + S-adenosyl-L-methionine <=> H(+) + kaempferide + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15821", "l": "2 A + glycine = 2 AH2 + CO2 + hydrogen cyanide"}, {"i": "EC:1.4.99.5", "l": "\"Glycine dehydrogenase (cyanide-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25854", "l": "2 [Fe(III)-cytochrome b5] + an (11Z)-Delta(11)-fatty acyl-CoA + 2 H2O => 2 [Fe(II)-cytochrome b5] + an 11,12-saturated fatty acyl-CoA + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015016", "l": "[heparan sulfate]-glucosamine N-sulfotransferase activity"}, {"i": "RHEA:21980", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n)"}, {"i": "EC:2.8.2.8", "l": "\"[Heparan sulfate]-glucosamine N-sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13375", "l": "3-hydroxy-4H-pyrid-4-one + L-serine => H2O + L-mimosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674019", "l": "BRAP binds KSR1:MARK3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451309", "l": "Edited Kainate Receptor binds glutamate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48047", "l": "ganglioside GM1 (d18:1(4E)/18:0) + H2O <=> D-galactose + ganglioside GM2 (d18:1(4E)/18:0)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388468", "l": "AVP(20-28) binds AVPR1A,B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40386", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP <=> 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16435", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein] => acetyl-CoA + N-terminal L-alanyl-[ribosomal protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33186", "l": "citrate(in) <=> citrate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18728", "l": "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA <=> acetyl-CoA + vanillin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004945", "l": "angiotensin type II receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63596", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0016418", "l": "S-acetyltransferase activity"}, {"i": "RHEA:41788", "l": "acetyl-CoA + holo-[ACP] = acetyl-[ACP] + CoA"}, {"i": "EC:2.3.1.38", "l": "\"[Acyl-carrier-protein] S-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29156", "l": "2 H(+)(out) + nitrite(out) + 3 ubiquinol-8(in) => 2 H2O(out) + NH4(+)(out) + 3 ubiquinone-8(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17338", "l": "catechol + O2 => (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56840", "l": "5-amino-2-hydroxybenzoate + O2 = (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate + H(+)"}, {"i": "EC:1.13.11.86", "l": "\"5-aminosalicylate 1,2-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19467", "l": "H(+) + NADP(+) + 2 nitrate => NADPH + 2 nitric oxide + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50786", "l": "(2E)-dodecenal + H(+) + NADPH => dodecanal + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43387", "l": "ATP + L-arginyl-[protein] <=> ADP + H(+) + N(omega)-phospho-L-arginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3095889", "l": "MMACHC reduces Cbl (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625188", "l": "HSPA8 transports unfolded substrate to lysosomal lumen for degradation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31549", "l": "15-cis-4,4'-diapophytoene + 2 diphosphate => 2 (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46841", "l": "4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34808", "l": "(R)-dihydrocamalexate + O2 + reduced [NADPH--hemoprotein reductase] => camalexin + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36699", "l": "3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP = 8-desmethylnovobiocic acid + AMP + diphosphate"}, {"i": "EC:6.3.1.15", "l": "\"8-demethylnovobiocic acid synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16958", "l": "3',5'-cyclic GMP + H2O => GMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37185", "l": "1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41801", "l": "acetyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9625482", "l": "PTK2 binds activated EGFR (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11302", "l": "2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH => 1D-5-O-methyl-myo-inositol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10129", "l": "all-trans-violaxanthin => all-trans-neoxanthin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60965", "l": "(9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + UDP-alpha-D-glucose => (9Z)-17-hydroxyoctadec-9-enoate 17-O-sophoroside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40178", "l": "O2 + octanoyl-CoA <=> (2E)-octenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24322", "l": "an L-N-hydroxypolyhomomethionine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an L-polyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617179", "l": "PRKACA phosphorylates TNNI3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "77.349316285872916", "identifiers": [{"i": "GO:0008422", "l": "beta-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047421", "l": "N-acyl-D-glutamate deacylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42278", "l": "4-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA => 2-methylbutanoyl-CoA + H(+) + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801675", "l": "PLK2 phosphorylates NPM1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156699", "l": "Inactivation of Wee1 kinase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11146", "l": "GDP-beta-L-galactose => GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54453", "l": "a 5,6-dihydrouridine in tRNA + NAD(+) => a uridine in tRNA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420661", "l": "Crumbs forms a ternary complex with Pals1 and PATJ at tight junctions (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36138", "l": "(2E)-hexadecenal + H2O + NAD(+) <=> (E)-hexadec-2-enoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483174", "l": "PE is methylated to PC by PEMT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917730", "l": "Cargo Recognition And Sorting (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30192", "l": "15-cis-phytoene + plastoquinone-9 => 15,9'-di-cis-phytofluene + plastoquinol-9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55116", "l": "5-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-5-methylhexanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848873", "l": "PTK6 phosphorylates ARAP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29903", "l": "ATP + D-ribose(out) + H2O = ADP + D-ribose(in) + H(+) + phosphate"}, {"i": "EC:7.5.2.7", "l": "\"ABC-type D-ribose transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141439", "l": "Release of activated MAD2 from kinetochores (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11948", "l": "4-hydroxybenzoyl-CoA + H2O = 4-hydroxybenzoate + CoA + H(+)"}, {"i": "EC:3.1.2.23", "l": "\"4-hydroxybenzoyl-CoA thioesterase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050522", "l": "oxidoreductase activity, acting on phosphorus or arsenic in donors, with other known acceptors"}, {"i": "EC:1.20.98.-", "l": "\"With other, known acceptors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42342", "l": "4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADH => 4-(gamma-L-glutamylamino)butanal + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.364", "l": "\"dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197958", "l": "FPGS-2 transforms THF to THFPG (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683792", "l": "p-T68-CHEK2 autophosphorylates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977375", "l": "CR1 binds C3bBb/C4bC2a (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24438", "l": "dihydromethanophenazine => H2 + methanophenazine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64026", "l": "H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) => 3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8),N'(8)-citryl-bis(spermidine)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159796", "l": "Furin cleaves pro-factor IX to factor IX (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322429", "l": "XIAP monoubiquinates TLE (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53382", "l": "H(+) + NADH + uridine(16) in tRNA => 5,6-dihydrouridine(16) in tRNA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983144", "l": "Transport of Antigen peptide in to ER (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685011", "l": "ATR activation at DNA DSBs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977301", "l": "Histidine is decarboxylated to histamine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75172", "l": "Formation of RAD50:MRE11 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74712", "l": "Dissociation of IRS-P from insulin receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39784", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0015373", "l": "anion:sodium symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5159250", "l": "ATF7IP binds SETDB1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678981", "l": "TLR9 processing at neutral pH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45787", "l": "2 H2O + phenylpropanonitrile <=> 3-phenylpropanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848713", "l": "PTK6 binds BCAR1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050144", "l": "nucleoside deoxyribosyltransferase activity"}, {"i": "MetaCyc:NUCLEOSIDE-DEOXYRIBOSYLTRANSFERASE-RXN"}, {"i": "EC:2.4.2.6", "l": "\"Nucleoside deoxyribosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38373", "l": "(9Z)-octadecenoate + glycerol + H(+) => 1-(9Z-octadecenoyl)-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106286", "l": "(E)-caffeate-CoA ligase activity"}, {"i": "RHEA:36299", "l": "(E)-caffeate + ATP + CoA = (E)-caffeoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399939", "l": "Autophosphorylation of PAK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28127", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose => alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34616", "l": "2-hydroxyethylphosphonate + O2 => H(+) + hydrogencarbonate + methylphosphonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19976", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> H(+) + S-methyl-5'-thioadenosine + spermine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730882", "l": "Phosphorylation of PKC-theta (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015099", "l": "nickel cation transmembrane transporter activity"}, {"i": "RHEA:29831", "l": "Ni(2+)(in) = Ni(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14411", "l": "H(+) + hypotaurine => cysteamine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37833", "l": "2-methyl-4-chlorophenol + CO2 + pyruvate + succinate => (S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25817", "l": "H2O + norspermine + O2 => 3-aminopropanal + H2O2 + norspermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45172", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018808", "l": "RAC3 binds effectors at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.n2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61292", "l": "(R)-pantoate + NAD(+) = 2-dehydropantoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004765", "l": "shikimate kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863718", "l": "AGFG1 binds VAMP7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69068", "l": "RFC dissociates after sliding clamp formation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429730", "l": "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046539", "l": "histamine N-methyltransferase activity"}, {"i": "REACT:R-HSA-175993", "l": "HNMT transfers CH3 group from AdoMet to Hist (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592240", "l": "Formation of NRF2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61987", "l": "H(+) + NADH + ubiquinone-10 <=> NAD(+) + ubiquinol-10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430308", "l": "PARVB interacts with Alpha-actinin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42831", "l": "2-hydroxy-5-methyl-1-naphthoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2,7-dihydroxy-5-methyl-1-naphthoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202604", "l": "Formation of a heteromeric BMP receptor complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043760", "l": "acetyldiaminopimelate aminotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44771", "l": "3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) <=> 2-methoxy-6-(all-trans-hexaprenyl)phenol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18395", "l": "2-methyl-3-oxopropanoate + L-alanine => (R)-3-amino-2-methylpropanoate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003986", "l": "acetyl-CoA hydrolase activity"}, {"i": "REACT:R-HSA-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617179", "l": "PRKACA phosphorylates TNNI3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-870538", "l": "TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8862280", "l": "FCHo proteins bind nascent clathrin-coated pit (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16921", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}, {"i": "EC:2.4.1.155", "l": "\"Alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58225", "l": "L-glutamyl-[protein] + NAD(+) => 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647977", "l": "ICMT methylates S-Farn RAS proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867041", "l": "EGFR phosphorylates EPS15 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686587", "l": "ABL1 phosphorylates RAD52 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27344", "l": "AH2 + NH4(+) + O2 <=> A + H(+) + H2O + hydroxylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1253343", "l": "WWOX binds ERBB4s80 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33206", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0051429", "l": "corticotropin-releasing hormone receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391942", "l": "IP receptor can bind prostacyclin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004154", "l": "dihydropterin oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9645220", "l": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40339", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63344", "l": "ATP + L-amino acyl-L-threonyl-[protein] = (S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700149", "l": "Active ALK binds PLCG1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050273", "l": "S-succinylglutathione hydrolase activity"}, {"i": "RHEA:16713", "l": "H2O + S-succinylglutathione = glutathione + H(+) + succinate"}, {"i": "EC:3.1.2.13", "l": "\"S-succinylglutathione hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14227", "l": "6-oxohexanoate + H(+) + NADH => 6-hydroxyhexanoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004633", "l": "phosphopantothenoylcysteine decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63788", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159773", "l": "Furin cleaves pro-protein S to protein S (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38875", "l": "uridine(2604) in 23S rRNA = pseudouridine(2604) in 23S rRNA"}, {"i": "EC:5.4.99.21", "l": "\"23S rRNA pseudouridine(2604) synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30727", "l": "dATP + pyruvate = dADP + H(+) + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851436", "l": "CFHR dimers bind C3b (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58496", "l": "choline + H(+) + NADH + O2 = glycolaldehyde + H2O + NAD(+) + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40018", "l": "(+)-copalyl diphosphate + H2O <=> 13-epi-manool + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-168166", "l": "NFkB complex is transported from cytosol to nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42140", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-(4R)-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649701", "l": "NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13802", "l": "3 H2O + hydrogen sulfide + 3 NADP(+) => 4 H(+) + 3 NADPH + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866269", "l": "ARRB bind GPCRs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21032", "l": "glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP"}, {"i": "EC:2.4.1.17", "l": "\"Glucuronosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12110", "l": "H(+) + N(omega)-methyl-L-arginyl-[histone] + S-adenosyl-L-homocysteine => L-arginyl-[histone] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9617595", "l": "SGTA binds mislocalized membrane protein (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418904", "l": "A1 and A3 receptors bind adenosine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062240", "l": "euchromatin-nuclear membrane anchor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37199", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684006", "l": "KPNA2 translocates NBN to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709831", "l": "HSP90 binds TBK1 and IRF3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61729", "l": "a 3-dehydro-D-guloside => a 3-dehydro-D-glucoside"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106008", "l": "2-oxoglutaramate amidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964912", "l": "DHAP from Ery4P and PEP (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675947", "l": "TNFSF18 binds TNFRSF18 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358789", "l": "Self-ubiquitination of RNF41 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45148", "l": "3-(methylsulfanyl)acryloyl-CoA + H2O = 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070324", "l": "thyroid hormone binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31430", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-exo-alpha-bergamotene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44447", "l": "a 1,2-diacylglycerol + H2O <=> a fatty acid + a monoacylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004131", "l": "cytosine deaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74718", "l": "Internalisation of the insulin receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8939201", "l": "ESR dimerizes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215426", "l": "COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050568", "l": "protein-glutamine glutaminase activity"}, {"i": "RHEA:16441", "l": "H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)"}, {"i": "EC:3.5.1.44", "l": "\"Protein-glutamine glutaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191830", "l": "snRNP nuclear import and release (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62964", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP-beta-L-fucose = alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848087", "l": "STAP2 recruits STAT3 to PTK6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35928", "l": "paromamine + UDP-alpha-D-glucose => 3''-deamino-3''-hydroxykanamycin C + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59340", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene + A = 1'-hydroxy-demethylspheroidene + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46111", "l": "(2E,6E,10E)-geranylgeraniol + H(+) + 2 NADPH + 2 O2 <=> (2E,6E,10E)-geranylgeranate + 3 H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30220", "l": "dimethyl sulfoxide + H2O + NAD(+) => dimethyl sulfone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8954056", "l": "E2F6 binds TFDP2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50367", "l": "(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-nandinine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45157", "l": "3-oxopropanoyl-CoA + H2O => 3-oxopropanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050188", "l": "phosphoenolpyruvate mutase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130706", "l": "MHC class II antigen processing (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61481", "l": "a sphingoid base + a very long-chain fatty acyl-CoA => an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31330", "l": "1D-myo-inositol 3-phosphate + CDP-1L-myo-inositol <=> bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990970", "l": "trans-activation response element binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19741", "l": "formyl-CoA + H2O = CoA + formate + H(+)"}, {"i": "EC:3.1.2.10", "l": "\"Formyl-CoA hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57581", "l": "S-methyl-5-thio-D-ribulose 1-phosphate => S-methyl-1-thiol-D-ribulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805122", "l": "AURKB binds TP53 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51349", "l": "acetyl-CoA + 10 AH2 + 2 H(+) + 7 malonyl-CoA + 5 S-adenosyl-L-methionine => 10 A + 7 CO2 + 8 CoA + dehydroprobetaenone I + 6 H2O + 5 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51126", "l": "pseudouridine in snRNA => uridine in snRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.7", "l": "\"ADP deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40552", "l": "demethylphylloquinol + S-adenosyl-L-methionine => H(+) + phylloquinol + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371591", "l": "Trimerization of cytosolic HSF1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63890", "l": "CoA + H(+) + N-hexadecanoyl-sphinga-4E,14Z-dienine => hexadecanoyl-CoA + sphinga-4E,14Z-dienine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.58", "l": "\"Russellysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879907", "l": "Tyrosine kinases phosphorylate the receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417842", "l": "P2Y10 receptor can bind to LPA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2089971", "l": "Secretion of collagens (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678843", "l": "ISGylation of protein translation regulator 4EHP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801762", "l": "REG3A oligomerize to form a pore complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28559", "l": "D-fructose 6-phosphate + H2O => D-fructose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788867", "l": "FN3K phosphorylates ketosamines (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018518", "l": "5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48157", "l": "ganglioside GQ1b (d18:1(4E)) + H2O => ganglioside GT1b (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24739", "l": "(6R)-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) => 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.58"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690873", "l": "ACO1 binds 4Fe-4S (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18144", "l": "NAD(+) + trans-cyclohexane-1,2-diol <=> 2-hydroxycyclohexan-1-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47243", "l": "H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40978", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O <=> 2 H(+) + 2 hexadecanoate + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43036", "l": "L-cysteine = 2-aminoprop-2-enoate + H(+) + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008923", "l": "lysine decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015648", "l": "lipid-linked peptidoglycan transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873918", "l": "Transphosphorylation of JAK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75244", "l": "FASL binds FAS Receptor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050558", "l": "maltose epimerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40614", "l": "H2O + trihexanoylglycerol <=> 2,3-dihexanoyl-sn-glycerol + H(+) + hexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59803", "l": "decanoyl-CoA + L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] <=> CoA + H(+) + N(6)-decanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61324", "l": "(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxycostunolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2889036", "l": "Translation of OCT4 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68960", "l": "DNA polymerase epsilon binds at the origin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225978", "l": "Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.9", "l": "\"Adenosylhomocysteine nucleosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35343", "l": "3-hydroxydocosanoyl-CoA + NADP(+) = 3-oxodocosanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296043", "l": "Activation of HCN channels (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112437", "l": "Formation of NELF complex  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15528", "l": "2-succinylbenzoyl-CoA <=> 1,4-dihydroxy-2-naphthoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451474", "l": "Bacterial Flagellin binds TLR5 homodimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76386", "l": "CYP1A2 S-demethylates 6MMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57499", "l": "2-methylcitrate <=> 2-methyl-cis-aconitate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050321", "l": "tau-protein kinase activity"}, {"i": "MetaCyc:TAU-PROTEIN-KINASE-RXN"}, {"i": "EC:2.7.11.26", "l": "\"[Tau protein] kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25049", "l": "(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O <=> (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25068", "l": "(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH => (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874082", "l": "MET phosphorylates PTK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809707", "l": "MTMR12 binds MTMR2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39150", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + CoA <=> (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212380", "l": "Formation of TRAP coactivator complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39179", "l": "(2E)-eicosenoyl-CoA + H(+) + NADPH = eicosanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445704", "l": "Calcium Binds Caldesmon (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18151", "l": "acetate + D-galactosamine 6-phosphate => H2O + N-acetyl-D-galactosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782895", "l": "TYW1:FMN:4Fe-4S  transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863463", "l": "STON2 binds SYT proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218815", "l": "p-6Y-VEGFR2 binds NCK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948757", "l": "AKT phosphorylates MKRN1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43121", "l": "2-oxoglutarate + O2 + xanthine => CO2 + succinate + urate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43342", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase] => [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140416", "l": "transcription regulator inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19078", "l": "H2O + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] => 3-deoxyglucosone + L-lysyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35033", "l": "L-serine(out) => L-serine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396599", "l": "Recruitment of GRB2:SOS to p-5Y-LAT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48865", "l": "2-methylpropan-1-amine + FADH2 + O2 => FAD + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.n2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043014", "l": "alpha-tubulin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944457", "l": "MAF1 translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645598", "l": "RRAGC,D hydrolyzes GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33939", "l": "H(+) + L-arginine + NADH + O2 = H2O + N(omega)-hydroxy-L-arginine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28892", "l": "H(+)(in) + putrescine(in) => H(+)(out) + putrescine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34063", "l": "2-deoxystreptamine + UDP-alpha-D-glucose = 2'-deamino-2'-hydroxyparomamine + H(+) + UDP"}, {"i": "EC:2.4.1.284", "l": "\"2-deoxystreptamine glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047032", "l": "3-alpha-hydroxyglycyrrhetinate dehydrogenase activity"}, {"i": "RHEA:20816", "l": "3alpha-hydroxyglycyrrhetinate + NADP(+) = 3-oxoglycyrrhetinate + H(+) + NADPH"}, {"i": "EC:1.1.1.230", "l": "\"3-alpha-hydroxyglycyrrhetinate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29063", "l": "a menaquinone + formate + H(+) = a menaquinol + CO2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001875", "l": "lipopolysaccharide immune receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24982", "l": "3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate => 3-hydroxy-4-methylanthranilate + ATP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019875", "l": "6-aminohexanoate-dimer hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1474210", "l": "Collagen type III degradation by MMP14 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944230", "l": "Association of procollagen type XVIII (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13485", "l": "2-oxoglutarate + S-(4-bromophenyl)-L-cysteine = 3-((4-bromophenyl)sulfanyl)-2-oxopropanoate + L-glutamate"}, {"i": "EC:2.6.1.75", "l": "\"Cysteine-conjugate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877153", "l": "STARD7 binds PC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956659", "l": "ABL1 phosphorylates YAP1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694435", "l": "MIA2 and MIA3 load procollagen VII into COPII vesicles (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58817", "l": "ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45679", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62323", "l": "(+)-premalbrancheamide + chloride + FAD + 2 H(+) <=> (+)-isomalbrancheamide B + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000263", "l": "TCII:Cbl is degraded to release Cbl (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41181", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+) => 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35271", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004435", "l": "phosphatidylinositol phospholipase C activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939204", "l": "ESTG binds ESR1:chaperone complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43348", "l": "cholesteryl (9Z-octadecenoate)(in) = cholesteryl (9Z-octadecenoate)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873926", "l": "IFNG dimer binds IFNGR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23377", "l": "L-threonate + NAD(+) => 3-dehydro-D-erythronate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849638", "l": "Dissociation of the SPINK5:KLK5 complex at low pH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62161", "l": "H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate => N-(9Z-octadecenoyl) ethanolamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18663", "l": "H(+) + L-ornithine + NADPH + pyruvate => H2O + N(5)-[1(S)-1-carboxyethyl]-L-ornithine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35114", "l": "2-dehydro-L-idonate + NADP(+) <=> 2,5-didehydro-D-gluconate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202947", "l": "Caspase mediated cleavage of APC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679239", "l": "ULK complex translocates to the ER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4086410", "l": "CDK1 phosphorylates BORA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33964", "l": "ATP + isopentenyl phosphate => ADP + isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2976716", "l": "NOTCH2 coactivator complex binds HES1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432148", "l": "Fgr may phosphorylate p38 MAPK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52107", "l": "a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052913", "l": "16S rRNA (guanine(966)-N(2))-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686699", "l": "Fusion and Release of SARS-CoV-1 Nucleocapsid (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211219", "l": "Translocation of caspase-3 to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34954", "l": "3-hydroxypropanoate(out) <=> 3-hydroxypropanoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17364", "l": "3-oxo-3-ureidopropanoate + H2O <=> H(+) + malonate + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449117", "l": "TXLNA (IL14) binds syntaxin1A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16512", "l": "H(+) + oxalate <=> CO2 + formate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198813", "l": "GSTO dimers reduce DeHA to AscH- (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52832", "l": "1-hydroxylimonen-2-one + H(+) + NADPH + O2 = 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804229", "l": "JMY, TTC5 and EP300 bind (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37684", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA => 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37065", "l": "2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine => 2-thio-N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429698", "l": "PRKD1,2,3 phosphorylates COL4A3BP-2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46642", "l": "7alpha-hydroxy-5beta-cholestan-3-one + NADP(+) => 7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34792", "l": "2-hydroxyethylphosphonate + O2 => formate + H(+) + hydroxymethylphosphonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804955", "l": "ATM phosphorylates MDM2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159733", "l": "Furin cleaves pro-factor X to factor X (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13109", "l": "2-acetamidofluorene + H2O + NAD(+) = H(+) + N-hydroxy-2-acetamidofluorene + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53939", "l": "O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 <=> 19-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34183", "l": "alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose = alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)"}, {"i": "EC:2.4.1.60", "l": "\"CDP-abequose:alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und alpha-1,3-abequosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791133", "l": "Expression of Sec31A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59041", "l": "4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 => 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2032781", "l": "WWTR1 (TAZ) binds TEAD (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60366", "l": "H(+)(in) + myo-inositol(in) => H(+)(out) + myo-inositol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51691", "l": "galactitol + NAD(+) <=> H(+) + keto-L-tagatose + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2076371", "l": "GLCE epimerises more GlcA to IdoA as sulfate content rises (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022141", "l": "Prolysyl oxidase activation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21201", "l": "2-oxoglutarate + L-lysine => (S)-2-amino-6-oxohexanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061605", "l": "molybdopterin-synthase adenylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707586", "l": "FeHM oxidises LDL,HDL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626982", "l": "TNF-alpha:TNFR1:NSMAF binds GNB2L1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28521", "l": "D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O <=> D-glycero-beta-D-manno-heptose 1-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62000", "l": "3 A + protoporphyrinogen IX = 3 AH2 + protoporphyrin IX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.19"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849908", "l": "SALM4 binds flotillin-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54559", "l": "5'-end ribonucleotide-tRNA(His) + ATP + H(+) <=> an adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32060", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + H2O => (R)-glycerate + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44973", "l": "(R)-carnitine + hexanoyl-CoA => CoA + O-hexanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043544", "l": "lipoamide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41921", "l": "3-oxooctadecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65931", "l": "3-bromo-2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine <=> 3-bromo-2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64016", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose = alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-Glc + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65916", "l": "L-kynurenine + pyruvate = H2O + kynurenate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64558", "l": "8-epi-ilicicolin H => 3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31667", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-glucose = dTDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate"}, {"i": "EC:2.6.1.89", "l": "\"dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55955", "l": "an inositol-1-phosphoceramide + GDP-alpha-D-mannose <=> a mannosylinositol-1-phospho-N-acyl-sphingoid base + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106076", "l": "peptide-lysine-N-succinyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20825", "l": "adenosine + ATP => ADP + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23962", "l": "CO2 + 3 H2O + pentadecanal => H(+) + 2 H2O2 + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445064", "l": "Activation of Rac1 by VAV2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70272", "l": "PGM:Mg2+ isomerise G6P to G1P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29762", "l": "octanoate(in) <=> octanoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8847534", "l": "RAB43 hydrolyses GTP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202443", "l": "Oligomerization of CARMA1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990137", "l": "plant seed peroxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66657", "l": "Cu(2+)(out) + L-ascorbate(in) => Cu(+)(out) + H(+) + monodehydro-L-ascorbate radical(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57862", "l": "CoA + scopoletin => (E)-6-hydroxyferuloyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36679", "l": "dTDP-6-deoxy-alpha-D-allose + NAD(+) = dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034787", "l": "1-hydro-1,1a-dihydroxy-9-fluorenone dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15711", "l": "H(+) + kaempferol 3-O-beta-D-galactoside + UDP => kaempferol + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56983", "l": "4-hydroxybenzyl alcohol + 2 oxidized [azurin] <=> 4-hydroxybenzaldehyde + 2 H(+) + 2 reduced [azurin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63361", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + O2 => (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-oxazole-[protein] + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549304", "l": "OCT3 mediates renal clearance of organic cations (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40520", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62989", "l": "dodecanamide + H2O => dodecanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203979", "l": "Coat Assembly (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51355", "l": "H2O + N-(9Z-octadecenoyl)-L-serine <=> (9Z)-octadecenoate + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39152", "l": "3-oxooctadecanoyl-CoA + H(+) + NADPH => (3R)-hydroxyoctadecanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56833", "l": "2,6-dichlorohydroquinone + chloride + glutathione disulfide + H(+) => 2,3,6-trichlorohydroquinone + 2 glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1220613", "l": "EGF-induced dimerization of ligand-responsive EGFR mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41036", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + hexadecanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-hexadecanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30058", "l": "L-allo-threonine + NADP(+) <=> (2S)-2-amino-3-oxobutanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19256", "l": "a sphingomyelin + H2O <=> an N-acylsphing-4-enine + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53680", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102404", "l": "linalyl 6-O-alpha-L-arabinopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070204", "l": "2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201717", "l": "CSNK2-mediated phosphorylation of DVL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018833", "l": "DDT-dehydrochlorinase activity"}, {"i": "MetaCyc:DDT-DEHYDROCHLORINASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21778", "l": "(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate => (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51165", "l": "cytidine(61) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(61) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.16"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22935", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16185", "l": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55574", "l": "4-hydroxy-N-methyltryptamine 4-phosphate + H(+) + S-adenosyl-L-homocysteine => 4-hydoxytryptamine 4-phosphate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57060", "l": "2''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+)"}, {"i": "RHEA:59244", "l": "3''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+)"}, {"i": "EC:3.1.1.106", "l": "\"O-acetyl-ADP-ribose deacetylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084912", "l": "Arresten binds integrin alpha1beta1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23461", "l": "benzyl cetraxate + H2O => benzyl alcohol + cetraxate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085992", "l": "SUMOylation of DAXX with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990887", "l": "2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10459", "l": "acetyl-CoA + D-maltose <=> 1-O-acetylmaltose + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371591", "l": "Trimerization of cytosolic HSF1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31367", "l": "2 H(+) + 3 nitrite = H2O + nitrate + 2 nitric oxide"}, {"i": "EC:1.7.6.1", "l": "\"Nitrite dismutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10625", "l": "2 ATP + CO2 + H2O + NH4(+) => 2 ADP + carbamoyl phosphate + 3 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102660", "l": "caffeoyl-CoA:shikimate O-(hydroxycinnamoyl)transferase activity"}, {"i": "MetaCyc:RXN-2621"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3209165", "l": "ID1 sequesters ETS2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212222", "l": "PRC2 recruits DNA methyltransferases (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3787997", "l": "Laminin-332 binds collagen type VII (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392295", "l": "Gbeta:gamma recruits PI3K gamma (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66312", "l": "an alpha-mannosylinositol-1-phosphoceramide + H2O = a D-mannosyl-alpha-1->6-inositol-1-phosphate + an N-acyl-sphingoid base + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64315", "l": "2 chloride + 2 FADH2 + 2 O2 + sulochrin <=> dihydrogeodin + 2 FAD + H(+) + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404131", "l": "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17225", "l": "1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin] = 6-hydroxynicotinate + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]"}, {"i": "EC:1.3.7.1", "l": "\"6-hydroxynicotinate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23474", "l": "alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose => 2 alpha,alpha'-trehalose 6-mycolate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003987", "l": "acetate-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158164", "l": "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944255", "l": "Association of procollagen type VII (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66773", "l": "ATP + H2O + uroporphyrin I(in) => ADP + H(+) + phosphate + uroporphyrin I(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43889", "l": "[sulfur carrier]-H + [sulfur-carrier protein]-S-sulfanyl-L-cysteine => [sulfur carrier]-SH + [sulfur-carrier protein]-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174731", "l": "Degradation of newly synthesized ApoB-48 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6813740", "l": "GDE1 hydrolyzes GroPIns (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852716", "l": "Thrombin, ELANE cleave C5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244424", "l": "botA:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61939", "l": "ATP + cycloheximide(in) + H2O <=> ADP + cycloheximide(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57893", "l": "a quinone + 5 H(+)(in) + NADPH => a quinol + 4 H(+)(out) + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55948", "l": "A + D-alanine + H2O = AH2 + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030731", "l": "guanidinoacetate N-methyltransferase activity"}, {"i": "MetaCyc:GUANIDINOACETATE-N-METHYLTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218804", "l": "p38 MAPK activation by VEGFR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11822", "l": "H(+) + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide => diphthamide-[translation elongation factor 2] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.12.1.-", "l": "\"Acting on sulfur-sulfur bonds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49065", "l": "2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol => calcitetrol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4088130", "l": "PLK1 binds FOXM1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22423", "l": "cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD(+) <=> 2 H(+) + maleylacetate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42931", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013143", "l": "RAC1 GEFs activate RAC1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63942", "l": "2 [Fe(III)-cytochrome b5] + 2 H2O + N-hexanoyl-sphinga-4E,14Z-dienine => 2 [Fe(II)-cytochrome b5] + 2 H(+) + N-(hexanoyl)sphing-4-enine + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043791", "l": "dimethylamine methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72671", "l": "eIF5B:GTP is hydrolyzed and released (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051424", "l": "corticotropin-releasing hormone binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36441", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41039", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + dodecanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-dodecanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690873", "l": "ACO1 binds 4Fe-4S (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55617", "l": "a carotenoid psi-end group => a carotenoid epsilon-end group"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120225", "l": "coenzyme A binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381727", "l": "RAP1A exchanges GDP for GTP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43939", "l": "androst-5-ene-3,17-dione <=> androst-4-ene-3,17-dione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13126", "l": "CoA + glutathione disulfide => CoA-glutathione + glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32383", "l": "(1S,2S,4R)-limonene-1,2-diol + NAD(+) = (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654409", "l": "Activated FGFR3 binds FRS2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66884", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 11-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19576", "l": "[phosphate](n) + ATP <=> [phosphate](n+1) + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64783", "l": "S-benzyl-L-cysteine <=> 2-aminoprop-2-enoate + benzylthiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41783", "l": "beta-D-Gal-(1<->1')-Cer + CMP-N-acetyl-beta-neuraminate <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13506", "l": "choline + O2 => betaine aldehyde + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28688", "l": "(S)-dihydroorotate + ubiquinone-8 => orotate + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098624", "l": "3'-phosphoadenylylselenate reductase activity"}, {"i": "REACT:R-HSA-2408548", "l": "PAPSe is reduced to SeO3(2-) by PAPSe reductase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43269", "l": "ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GM2 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851979", "l": "BTNL9 binds immune cell surfaces (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080018", "l": "anthocyanin 5-O-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419049", "l": "ROCK activation by RHO (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450494", "l": "HuR binds mRNAs in the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50210", "l": "cortisone + H(+) + NADH => cortisol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160935", "l": "SMURF1 ubiquitinates RHOA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30843", "l": "H2O + N-formylmaleamate = formate + H(+) + maleamate"}, {"i": "EC:3.5.1.106", "l": "\"N-formylmaleamate deformylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25240", "l": "ATP + CDP <=> ADP + CTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66808", "l": "5-aminopentanoate + acetyl-CoA + 17 H(+) + 7 malonyl-CoA + 11 NADPH = 7 CO2 + 8 CoA + 6 H2O + 11 NADP(+) + wortmanamide A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20015", "l": "H(+) + N-carbamoyl-L-aspartate + phosphate => carbamoyl phosphate + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54666", "l": "pre-alpha-onocerin => (3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59034", "l": "4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => (Z)-24-ethylidenelophenol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63196", "l": "(10bR,4aS)-noroxomaritidine + H(+) + NADPH = (10bR,4aS)-oxomaritidine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961632", "l": "POLA1 gene transcription is stimulated by E2F1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102552", "l": "lipoyl synthase activity (acting on glycine-cleavage complex H protein"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57295", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O <=> a guanosine in RNA + glycolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388829", "l": "SHP2 phosphatase binds CTLA-4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047857", "l": "dihydrouracil oxidase activity"}, {"i": "KEGG.REACTION:R00975"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004557", "l": "alpha-galactosidase activity"}, {"i": "MetaCyc:ALPHAGALACTOSID-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77077", "l": "Capping complex formation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000834", "l": "inositol heptakisphosphate 6-kinase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0004058", "l": "aromatic-L-amino-acid decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51135", "l": "a purine 2'-deoxyribonucleoside 5'-phosphate + H2O <=> 2-deoxy-D-ribose 5-phosphate + a purine nucleobase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202328", "l": "Translocation of PKC theta to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25971", "l": "(S)-benzoin + NADP(+) <=> benzil + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948775", "l": "MKRN1 polyubiquitinates PTEN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31794", "l": "H2O + tuberculosinyl diphosphate <=> (13S)-edaxadiene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35021", "l": "L-threonine(out) => L-threonine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46999", "l": "6-hydroxy-N-methylmyosmine + H2O <=> 6-hydroxypseudooxynicotine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1299318", "l": "Activation of TASK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052759", "l": "coenzyme F420-dependent 2,4,6-trinitrophenol hydride reductase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018743", "l": "phenanthrene-9,10-epoxide hydrolase (9R,10R-forming) activity"}]}
{"type": "biolink:MolecularActivity", "ic": "65.48928698272745", "identifiers": [{"i": "GO:0016410", "l": "N-acyltransferase activity"}, {"i": "REACT:R-HSA-177160", "l": "phenylacetyl-CoA + glutamine => phenylacetyl glutamine + Coenzyme A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2029468", "l": "Conversion of PA into DAG by PAP-1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59296", "l": "an N-acylglycine + 2 L-ascorbate + O2 = an N-acyl-(2S)-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168644", "l": "CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54948", "l": "(3R)-hydroxy-(5Z)-dodecenoyl-[ACP] = (2E,5Z)-dodecadienoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601924", "l": "Primary piRNA transcript translocates from nucleoplasm to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862700", "l": "CMKLR1 binds Resolvin E1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046848", "l": "hydroxyapatite binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9649733", "l": "mature p21 RAS binds GDP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47462", "l": "(3Z)-dodecenoyl-CoA + acetyl-CoA => 3-oxo-(5Z-tetradecenoyl)-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72127", "l": "Formation of the Spliceosomal B Complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40273", "l": "(2E)-tetradecenedioyl-CoA + H2O2 => O2 + tetradecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473596", "l": "Collagen type I degradation by MMP15 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48917", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b => CMP + ganglioside GD1c + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64519", "l": "2-hydroxyethane-1-sulfonate + NAD(+) <=> H(+) + NADH + sulfoacetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18459", "l": "(2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+) => D-ribulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.45", "l": "\"Memapsin 1\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196857", "l": "PANK2 phosphorylates PanK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34430", "l": "(-)-lariciresinol + NADP(+) <=> (-)-pinoresinol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31779", "l": "an all-trans-retinyl ester + H2O = 13-cis-retinol + a fatty acid + H(+)"}, {"i": "EC:3.1.1.90", "l": "\"All-trans-retinyl ester 13-cis isomerohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9733973", "l": "Bile salts bind FABP6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63098", "l": "ilicicolin C => ilicicolin A epoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51137", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 2 O2 => (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928624", "l": "EPHBs bind EFNBs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10003", "l": "H2O + pentanamide <=> NH4(+) + pentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102695", "l": "UDP-glucose:cis-zeatin 7-N-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-4733"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10937", "l": "6-decylubiquinone + 2 thiosulfate => 6-decylubiquinol + tetrathionate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.11"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0003730", "l": "mRNA 3'-UTR binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800794", "l": "PIDD1 associates with CRADD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8963864", "l": "CUBN dissociates from 25(OH)D (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814555", "l": "Integrator complex processes the 3' end of snRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156661", "l": "Formation of Exon Junction Complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21589", "l": "N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate => H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63356", "l": "(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + O2 = (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-thiazole-[protein] + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034281", "l": "ent-isokaurene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.-", "l": "\"Aminopeptidases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20796", "l": "aldehydo-D-ribose = D-ribulose"}, {"i": "EC:5.3.1.20", "l": "\"Ribose isomerase\""}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0016420", "l": "malonyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950731", "l": "CRLF1:IL27 translocates to the extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008052", "l": "IL1F10(?-152) binds IL1RAPL1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37135", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate = 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186780", "l": "PI3-kinase binds to the active receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2077421", "l": "FP-1039 acts as a ligand-trap for FGFR2b-binding ligands in endometrial cancer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40558", "l": "dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2 <=> dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4411402", "l": "Activation of NLK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682020", "l": "MRN complex binds shortened telomeres (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18167", "l": "(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) => biphenyl + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36787", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-galactosamine = N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP"}, {"i": "EC:2.7.8.40", "l": "\"UDP-N-acetylgalactosamine-undecaprenyl-phosphate N-acetylgalactosaminephosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex. (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710263", "l": "GZMB cleaves GSDME (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004069", "l": "L-aspartate:2-oxoglutarate aminotransferase activity"}, {"i": "RHEA:21824", "l": "2-oxoglutarate + L-aspartate = L-glutamate + oxaloacetate"}, {"i": "EC:2.6.1.1", "l": "\"Aspartate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63314", "l": "15-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043831", "l": "thiosulfate dehydrogenase (quinone) activity"}, {"i": "MetaCyc:1.8.5.2-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40867", "l": "(9E)-octadecenoyl-CoA + FAD + H(+) = (2E,9E)-octadecadienoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70596", "l": "GOT2 dimer deaminates L-Asp (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24902", "l": "cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H(+)"}, {"i": "EC:3.1.4.52", "l": "\"Cyclic-guanylate-specific phosphodiesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56182", "l": "2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 2 AH2 + CO2 => 8-carboxy-8-demethylriboflavin 5'-phosphate + 2 A + H2O + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952419", "l": "SMURFs ubiquitinate RUNX3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047795", "l": "cyclohexane-1,2-diol dehydrogenase activity"}, {"i": "MetaCyc:CYCLOHEXANE-12-DIOL-DEHYDROGENASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63491", "l": "9,10-phenanthroquinone + H(+) + NADPH <=> NADP(+) + phenanthrene-9,10-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5632677", "l": "PTCH is internalized (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450551", "l": "AUF1 binds translation and heat shock proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031780", "l": "corticotropin hormone receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56809", "l": "ATP + cob(I)yrinate a,c diamide--[corrinoid adenosyltransferase] => adenosylcob(III)yrinate a,c-diamide + apo-[corrinoid adenosyltransferase] + triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696822", "l": "AKR1B15 reduces EST17b to E1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53215", "l": "17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta,18-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25490", "l": "(1S,5S)-alpha-pinene + diphosphate => (2E)-geranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2186771", "l": "RNF111 binds SMAD7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209108", "l": "Membrane-bound GISH binds to ARR receptor complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29048", "l": "a menaquinone + 2 H(+)(in) + H2 => a menaquinol + 2 H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57834", "l": "glutarate + 2 H(+) + NADPH => 5-oxopentanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34908", "l": "molybdate(in) => molybdate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388596", "l": "Melanocortin receptors bind melanocortins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692408", "l": "NPR2 binds NPPC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66787", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(out) <=> 6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467738", "l": "A2E translocates to RPE cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9617927", "l": "FOXO4 binds ATXN3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018798", "l": "RHOV binds GTP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60254", "l": "acryloyl-CoA + CO2 + NADPH => (S)-methylmalonyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66888", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 8-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102932", "l": "pterocarpan reductase activity"}, {"i": "MetaCyc:RXN-8936"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035527", "l": "3-hydroxypropionate dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419843", "l": "CALCA(83-119) binds CALCR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25007", "l": "2 H(+) + H2O + N-hydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase] => L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31048", "l": "(S)-methylmalonate semialdehyde + CoA + NAD(+) => CO2 + NADH + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158118", "l": "factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59219", "l": "(indol-3-yl)acetate + H(+) <=> CO2 + skatole"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110219", "l": "Cleavage of thymine by TDG glycosylase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204863", "l": "Interaction of Tie2 with Ang2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201611", "l": "Caspase-mediated cleavage of Rock-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12305", "l": "(S)-2-amino-6-oxohexanoate + H2O + NADP(+) => 2 H(+) + L-2-aminoadipate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49354", "l": "2'-hydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63138", "l": "cob(I)alamin--[alkylcobalamin reductase] + H(+) + S-adenosylglutathione => adenosylcob(III)alamin + apo--[alkylcobalamin reductase] + glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706323", "l": "Active FLT3 binds to SLA2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451508", "l": "Nuclear translocation of phospho ERK2 dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19844", "l": "H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10269", "l": "2-dehydro-3-deoxy-D-glucarate => 2-hydroxy-3-oxopropanoate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684261", "l": "MAP3K8 is phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60577", "l": "[methyl-Co(III) tetramethylammonium-specific corrinoid protein] + coenzyme M => [Co(I) tetramethylammonium-specific corrinoid protein] + H(+) + methyl-coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39836", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 1-(9Z-octadecenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002948", "l": "archaeosine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43558", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465926", "l": "An atROL isomerase isomerises atROL to 11cROL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65300", "l": "2-oxoglutarate + chrodrimanin C + O2 = CO2 + H2O + succinate + verruculide A"}]}
{"type": "biolink:MolecularActivity", "ic": "76.711710297129045", "identifiers": [{"i": "GO:0004713", "l": "protein tyrosine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033828", "l": "glucosylglycerol-phosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15388", "l": "L-asparagine <=> 3-cyano-L-alanine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350453", "l": "RHOGAPP190 binds to RHO1:GTP complex at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24260", "l": "(3E)-2-oxohex-3-enedioate + H(+) = 2-oxopent-4-enoate + CO2"}, {"i": "EC:4.1.1.77", "l": "\"2-oxo-3-hexenedioate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65991", "l": "previtamin D3 <=> calciol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694522", "l": "Inner coat assembly and cargo binding (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47337", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 16beta,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373087", "l": "Receptor CCR6 binds CCL20 ligand (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0001091", "l": "RNA polymerase II general transcription initiation factor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604360", "l": "Initial activation of proMMP2 by MMP14 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043895", "l": "cyclomaltodextrin glucanotransferase activity"}, {"i": "MetaCyc:2.4.1.19-RXN"}, {"i": "EC:2.4.1.19", "l": "\"Cyclomaltodextrin glucanotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696465", "l": "USP45 deubiquitinates ERCC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29098", "l": "5 H(+)(in) + NADH + ubiquinone-8 <=> 4 H(+)(out) + NAD(+) + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52246", "l": "2 H2O + 4 Mn(3+) => 4 H(+) + 4 Mn(2+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189456", "l": "Mitochondrial dALA translocates to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31276", "l": "(S)-3-hydroxy-2-methylpropanoate + NAD(+) => (S)-methylmalonate semialdehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25071", "l": "3-hydroxybenzoate + ATP + CoA => 3-hydroxybenzoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17646", "l": "H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] => N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72103", "l": "Formation of pre-mRNPs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59279", "l": "L-glutamine <=> D-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018754", "l": "GDIs bind RHOH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32506", "l": "linalool + O2 + reduced [NADPH--hemoprotein reductase] <=> (6E)-8-hydroxylinalool + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48603", "l": "[protein-PII]-uridylyl-L-tyrosine + H2O <=> [protein-PII]-L-tyrosine + H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177926", "l": "Dephosphorylation of PAG by SHP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654603", "l": "Activated FGFR2 binds FRS3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15223", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+) => a CDP-1,2-diacyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35994", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698931", "l": "C Nucleocapsid Assembly (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53561", "l": "9,10-epoxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-9,10-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042284", "l": "sphingolipid delta-4 desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.158", "l": "\"Alpha-agarase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.69", "l": "\"5-hydroxyfuranocoumarin 5-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35895", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54525", "l": "acetoacetate + H(+) + methylglyoxal => 3-hydroxyhexane-2,5-dione + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16528", "l": "2-dehydro-3-deoxy-D-galactonate + ATP <=> 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9607301", "l": "Active FLT3:GRB2 binds SOS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084505", "l": "Laminins bind HSPG2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20286", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate => alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14335", "l": "6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol => a 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46343", "l": "ATP + N-hexadecanoylsphing-4-enine <=> ADP + H(+) + N-(hexadecanoyl)-sphing-4-enine-1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9693243", "l": "RHOD translocates to the Golgi membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25144", "l": "3-hydroxy-L-kynurenine + H2O => 3-hydroxyanthranilate + H(+) + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18323", "l": "4-methyl-2-oxopentanoate + L-glutamate => 2-oxoglutarate + L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112395", "l": "Abortive termination of elongation after arrest (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33384", "l": "(S)-malate + UDP-N-acetyl-alpha-D-glucosamine => (S)-malyl N-acetyl-alpha-D-glucosaminide + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341016", "l": "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16120", "l": "acetoacetate + ATP + CoA <=> acetoacetyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44204", "l": "2-hydroxyhexadecanoate + ATP + CoA = 2-hydroxyhexadecanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449077", "l": "Interleukin-16 is secreted (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28585", "l": "ATP + dUDP <=> ADP + dUTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47412", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48342", "l": "a medium-chain fatty acyl-CoA + AMP + diphosphate => a medium chain fatty acid + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65983", "l": "hnu + previtamin D3 <=> tachysterol 3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43140", "l": "guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.216", "l": "\"tRNA (guanine(26)-N(2))-dimethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000332", "l": "template for synthesis of G-rich strand of telomere DNA activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9650165", "l": "ASIC trimers bind H+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140259", "l": "PRC1 complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48999", "l": "3-methylcatechol + O2 <=> 2-hydroxy-6-oxo-2,4-heptadienoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30444", "l": "2 glycyl-tRNA(Gly) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc => 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5226999", "l": "ADD1:ADD3 binds DMTN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047456", "l": "2-methylisocitrate dehydratase activity"}, {"i": "KEGG.REACTION:R04425"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60892", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O = a 5'-end phospho-ribonucleoside in snoRNA + H(+) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.4", "l": "\"Cellulase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12100", "l": "1,5-anhydro-D-fructose = H2O + microthecin"}, {"i": "EC:4.2.1.110", "l": "\"Aldos-2-ulose dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381496", "l": "Formation of the IGF:IGFBP3:ALS complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25016", "l": "H(+) + N,N-dihydroxy-L-tryptophan <=> (E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047554", "l": "2-pyrone-4,6-dicarboxylate lactonase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18471", "l": "an N(2)-acyl-L-glutamine + CoA + H(+) => an acyl-CoA + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0000406", "l": "double-strand/single-strand DNA junction binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692408", "l": "NPR2 binds NPPC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941312", "l": "ZCCHC6, ZCCHC11 are mRNA uridyltransferases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41128", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O => 1-dodecanoyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20909", "l": "3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2247514", "l": "SCARF1:ligand is endocytosed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63085", "l": "chloride + FADH2 + ilicicolin B + O2 => FAD + H(+) + 2 H2O + ilicicolin A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14882", "l": "3-sulfanyl-2-(sulfanylmethyl)propanoate + NAD(+) => asparagusate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610627", "l": "KIF17 transports GluN1:GluN2B (GRIN1:GRIN2B) NMDA receptors to the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20551", "l": "2 [Fe(II)cytochrome c] + 2 H(+) + tetrathionate => 2 [Fe(III)cytochrome c] + 2 thiosulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23078", "l": "2,4-dichlorobenzoyl-CoA + NADPH => 4-chlorobenzoyl-CoA + chloride + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29043", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)"}, {"i": "EC:2.1.1.148", "l": "\"Thymidylate synthase (FAD)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40406", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP <=> 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028728", "l": "NTRK2 phosphorylates FRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683888", "l": "LMCD1 binds GATA6, sequestering it (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018563", "l": "2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670054", "l": "Defects in F8 A2 domain accelerate dissociation of the A2 domain (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956568", "l": "RUNX1 binds the core TAL1 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016905", "l": "myosin heavy chain kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10617", "l": "(2R,3S)-catechin + H2O + NADP(+) => (2R,3S,4S)-leucocyanidin + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432535", "l": "TIM is phosphorylated by CK2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29411", "l": "glycolate(in) + H(+)(in) = glycolate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692749", "l": "CDC14A,B bind MAPK6 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19551", "l": "H(+) + 2 orsellinate => H2O + orsellinate depside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617829", "l": "Assembly of IFT A complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202489", "l": "Oligomerization of Bcl10 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58991", "l": "(E)-4-hydroxynon-2-enal + H2O + O2 <=> (E)-4-hydroxynon-2-enoate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50300", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-4-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211968", "l": "CYP2W1 oxidises INDOL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865626", "l": "p-STAT5 dimers bind the BRWD1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019855", "l": "calcium channel inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008474", "l": "palmitoyl-(protein) hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55827", "l": "a 7(1),7(1)-dihydroxybacteriochlorophyllide d <=> a bacteriochlorophyllide f + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613497", "l": "Unwinding DNA for the nascent transcript (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624925", "l": "miR-33 binds to the 3'UTR of the ABCA1 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48831", "l": "H(+) + NADPH + O2 + resorcinol <=> benzene-1,2,4-triol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.6", "l": "\"Endo-1,3(4)-beta-glucanase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26188", "l": "1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP"}, {"i": "EC:2.4.1.250", "l": "\"D-inositol-3-phosphate glycosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35603", "l": "beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437230", "l": "L1-FGFR cis-heterodimerization (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809975", "l": "PI3P is dephosphorylated to PI by the MTMR2:SBF2 tetramer at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66572", "l": "2-naphthol + 3'-phosphoadenylyl sulfate = 2-naphthyl sulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210273", "l": "Interaction of DAP12 and NKp44 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31884", "l": "(S)-2,3-epoxysqualene => delta-amyrin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77094", "l": "Formation of cap binding complex (CBC) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30361", "l": "chlorophyllide b + 3 H2O + 2 NADP(+) => chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467811", "l": "Separation of sister chromatids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29612", "l": "H2O + NADP(+) + nitrous oxide => H(+) + NADPH + 2 nitric oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51305", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate => (13R)-hydroperoxy-(9Z,11E)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59807", "l": "L-phenylalanine <=> D-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44657", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a monoacyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5576895", "l": "SCNAs:SNCBs transport Na+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22476", "l": "4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+) = 4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14132", "l": "cholate + NADP(+) <=> 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672083", "l": "KTN1 binds Kinesin-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42455", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate <=> H2O + kynurenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51069", "l": "(2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + pyruvate => (3S,5R,10R,12S,14S,15R,16R)-3,5,10,14,15-pentahydroxy-12,16-dimethylicosan-2-one + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013147", "l": "RAC1 GDIs block activation of RAC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36168", "l": "a 2'-deoxyribonucleoside 5'-phosphate + H2O => a 2'-deoxyribonucleoside + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49185", "l": "chlorophyllide a + H(+) + H2O => 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + CO2 + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794352", "l": "NRXNs binds CASK tripartite complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33842", "l": "(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin + H(+) <=> 7-O-geranyl-2-O,3-dimethylflaviolin + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13387", "l": "2-undecanone + CO2 => 3-oxododecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187506", "l": "Translocation of p27 to the nucleoplasm (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050074", "l": "malate-CoA ligase activity"}, {"i": "RHEA:26193", "l": "(S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate"}, {"i": "EC:6.2.1.9", "l": "\"Malate--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559468", "l": "TLR1/2 ligand binds to CD14 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18461", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}, {"i": "EC:2.3.1.67", "l": "\"1-alkylglycerophosphocholine O-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-434989", "l": "SEMA7A binds to PLXNC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22879", "l": "(R)-mandelamide + H2O <=> (R)-mandelate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42818", "l": "cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018826", "l": "RHOT2 hydrolyzes GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55471", "l": "11-hydroxyferruginol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11,20-dihydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11829", "l": "H2O + RNA(n)-2',3'-cyclic phosphate => H(+) + RNA(n)-2'- phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0061920", "l": "protein propionyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001790", "l": "polymeric immunoglobulin binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047897", "l": "formate-dihydrofolate ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655170", "l": "RCHY1 monoubiquitinates POLH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28923", "l": "H(+)(in) + L-phenylalanine(in) = H(+)(out) + L-phenylalanine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14722", "l": "UDP-alpha-D-xylose + zeatin => H(+) + O-beta-D-xylosylzeatin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870461", "l": "RABGGTA and RABGGTB bind (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036311", "l": "chitin disaccharide deacetylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64094", "l": "3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+) => 3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602458", "l": "Activation of proMMP10 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39025", "l": "an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36536", "l": "docosanoyl-CoA + sphinganine => CoA + H(+) + N-docosanoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64441", "l": "glycylglycyl-L-proline(out) + H(+)(out) => glycylglycyl-L-proline(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49927", "l": "(R)-carnitine(out) + O-acyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-acyl-(R)-carnitine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1370500", "l": "PRLR binds SCF beta-TrCP complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22969", "l": "butanal + CoA + NAD(+) => butanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62297", "l": "(+)-premalbrancheamide + 2 chloride + 2 FAD + 4 H(+) => (+)-malbrancheamide + 2 FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70481", "l": "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874083", "l": "p-Y397-PTK2 binds SRC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005522", "l": "profilin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46400", "l": "cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-cholest-5-ene-3beta,26-diol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37374", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O <=> a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58126", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + polyneuridine aldehyde => (19S)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20424", "l": "alpha-maltose 6'-phosphate + H2O <=> D-glucose + D-glucose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803527", "l": "ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928625", "l": "PAKs autophosphorylate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9626817", "l": "PKC phosphorylates NCF1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33431", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate = (3E)-2-oxohex-3-enedioate"}, {"i": "EC:5.3.2.6", "l": "\"2-hydroxymuconate tautomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706393", "l": "RHOBTB3 binds ATP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.28", "l": "\"Picornain 3C\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34887", "l": "selenate(in) = selenate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29326", "l": "fumarate(in) + succinate(out) <=> fumarate(out) + succinate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35092", "l": "anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine => 2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32093", "l": "dTDP + erythromycin D + H(+) => 3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17804", "l": "acetyl-CoA + L-phenylalanine <=> CoA + H(+) + N-acetyl-L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17604", "l": "ATP + D-ribulose <=> ADP + D-ribulose 5-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48392", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + GDP-beta-L-fucose = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400012", "l": "Acetylcholine binds Muscarinic Acetylcholine Receptor M3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34599", "l": "15-methylhexadecasphinganine + NADP(+) = 3-dehydro-15-methylhexadecasphinganine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53691", "l": "2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O <=> (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654422", "l": "Activated FGFR4 binds FRS2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51667", "l": "D-5-phenylhydantoin + H2O <=> H(+) + N-carbamoyl-D-phenylglycine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008689", "l": "3-demethylubiquinone-9 3-O-methyltransferase activity"}, {"i": "RHEA:17049", "l": "3-demethylubiquinol-9 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25990", "l": "albaflavenone + 2 H2O + NADP(+) => (5R)-albaflavenol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432956", "l": "BP230 is recruited to the hemidesmosome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31059", "l": "H2O + imidazole-4-acetaldehyde + NAD(+) = 2 H(+) + imidazole-4-acetate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.33"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54030", "l": "a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14445", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38181", "l": "19-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654569", "l": "Activated FGFR1 binds FRS2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696947", "l": "USP47 deubiquitinates POLB (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21443", "l": "a long-chain fatty aldehyde + H(+) + 2 NADPH + O2 <=> a long-chain alkane + formate + H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-209792", "l": "N-acetylation of serotonin (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62475", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-nonadioyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62783", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-984606", "l": "Kinesin-5 is a homotetramer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5658438", "l": "SPRED dimer binds NF1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33954", "l": "ribostamycin + UDP-N-acetyl-alpha-D-glucosamine <=> 2'''-acetyl-6'''-hydroxyneomycin C + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31386", "l": "(S)-2,3-epoxysqualene <=> lupeol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43156", "l": "guanosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.221", "l": "\"tRNA (guanine(9)-N(1))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28673", "l": "2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate => 2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12604", "l": "2-oxoglutarate + L-2-aminoadipate <=> 2-oxoadipate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443779", "l": "Linkage of L1 with treadmilling F-actin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39978", "l": "2-iminobutanoate + H2O <=> 2-oxobutanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49600", "l": "ATP + CoA + octanedioate = AMP + diphosphate + octanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32488", "l": "CDP-choline + H2O => CMP + 2 H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21633", "l": "2 catechol + O2 => 2 1,2-benzoquinone + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0052882", "l": "oxidoreductase activity, acting on phosphorus or arsenic in donors, with a copper protein as acceptor"}, {"i": "EC:1.20.9.-", "l": "\"With a copper protein as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34394", "l": "beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 UDP-alpha-D-galactofuranose <=> [beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 H(+) + 28 UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22250", "l": "7,8-dihydroxykynurenate + H(+) + NADH => 7,8-dihydro-7,8-dihydroxykynurenate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33637", "l": "AMP + diphosphate + docosanoyl-CoA => ATP + CoA + docosanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033914", "l": "xylan 1,3-beta-xylosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.13", "l": "\"D-alanine--poly(phosphoribitol) ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35632", "l": "cyanidin + UDP-alpha-D-galactose => cyanidin 3-O-beta-D-galactoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30619", "l": "2 A + all-trans-zeta-carotene = 2 AH2 + all-trans-lycopene"}, {"i": "EC:1.3.99.26", "l": "\"All-trans-zeta-carotene desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "78.423603998002051", "identifiers": [{"i": "GO:0016247", "l": "channel regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27824", "l": "acetate + L-homocysteine => hydrogen sulfide + O-acetyl-L-homoserine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050520", "l": "phosphatidylcholine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669240", "l": "FLNA binds PAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875568", "l": "RAPGEF1 activates RAP1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10510", "l": "aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate => D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57383", "l": "(S)-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] <=> (13S,14R)-1,13-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30231", "l": "H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine = (2E,6E)-farnesal + H2O2 + L-cysteine"}, {"i": "EC:1.8.3.6", "l": "\"Farnesylcysteine lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-912734", "l": "CBL:CRKL binds RAPGEF1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59709", "l": "D-maltotriono-1,5-lactone + H2O => D-maltotrionate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0043225", "l": "ATPase-coupled inorganic anion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433711", "l": "Cis-homodimerization of nectins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27594", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 5 isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + 5 diphosphate"}, {"i": "EC:2.5.1.85", "l": "\"All-trans-nonaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62592", "l": "(S)-8-oxocitronellyl enol + NADP(+) = (6E)-8-oxogeranial + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12208", "l": "4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)"}, {"i": "EC:3.1.1.56", "l": "\"Methylumbelliferyl-acetate deacetylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19372", "l": "L-histidyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50687", "l": "H2O + N(5)-phenyl-L-glutamine <=> aniline + H(+) + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686663", "l": "Completion of SSA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9012835", "l": "GDIs block activation of RHOA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322434", "l": "XIAP dissociates from ub-TLE (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21648", "l": "H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O"}, {"i": "EC:4.2.1.51", "l": "\"Prephenate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019010", "l": "farnesoic acid O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043731", "l": "6-hydroxynicotinate 3-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877308", "l": "Dephosphorylation of JAKs by PTPs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27853", "l": "glycine + phenylacetyl-CoA <=> CoA + H(+) + phenylacetylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34296", "l": "2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose => 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051506", "l": "ergosterol UDP-glucosyltransferase activity"}, {"i": "RHEA:61836", "l": "ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D-glucoside + H(+) + UDP"}, {"i": "MetaCyc:RXN-16975)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102329", "l": "hentriaconta-3,6,9,12,19,22,25,28-octaene-16-one-15-oyl-CoA reductase activity"}, {"i": "MetaCyc:RXN-13251"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12751", "l": "1,2,3-trihydroxybenzene + CO2 => 3,4,5-trihydroxybenzoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373711", "l": "DCC interaction with Netrin-1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866941", "l": "MID1IP1 binds THRSP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.35"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46757", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357845", "l": "RIPK1 is deubiquitinated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15693", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + AH2 = (R)-2-hydroxy-(9Z,12Z,15Z)-octadecatrienoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56173", "l": "FMN + O2 => 8-demethyl-8-formylriboflavin 5'-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42797", "l": "(9Z,12Z)-octadecadienoyl-CoA + cholesterol => cholesteryl (9Z,12Z)-octadecadienoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.34"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113402", "l": "Formation of DSIF:NELF:early elongation complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3878123", "l": "Initiation of SAHF formation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63041", "l": "H2O + lovastatin => H(+) + lovastatin carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21024", "l": "CoA + glyoxylate + NADP(+) = H(+) + NADPH + oxalyl-CoA"}, {"i": "EC:1.2.1.17", "l": "\"Glyoxylate dehydrogenase (acylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11328", "l": "dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate"}, {"i": "EC:2.5.1.28", "l": "\"Dimethylallylcistransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051717", "l": "inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity"}, {"i": "MetaCyc:3.1.3.62-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12650", "l": "L-rhamnofuranose + NAD(+) => H(+) + L-rhamnono-1,4-lactone + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222512", "l": "Nitric oxide oxidizes to nitrosyl ion (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190065", "l": "Activated TrkA receptor internalizes to endosomes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018816", "l": "2-hydroxyisobutyrate dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58133", "l": "A + ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] => AH2 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + serpentine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68611", "l": "Formation of ORC(1-5) complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51251", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17440", "l": "2,4-dichloro-5-oxo-2,5-dihydro-2-furylacetate <=> (2E,4E)-2,4-dichloromuconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36204", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + ethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40525", "l": "a quinol + fumarate => a quinone + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016496", "l": "substance P receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19249", "l": "glyoxylate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50838", "l": "14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990404", "l": "protein ADP-ribosylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55771", "l": "all-trans-retinoate + UDP-alpha-D-glucuronate <=> all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211950", "l": "CYP24A1 24-hydroxylates CTL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19465", "l": "NADPH + 2 nitric oxide + 2 O2 = H(+) + NADP(+) + 2 nitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404135", "l": "RBP4 binds atROL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139920", "l": "Translocation of tBID to mitochondria (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54153", "l": "a uridine in rRNA + S-adenosyl-L-methionine => a 2'-O-methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57412", "l": "AMP + diphosphate + L-tyrosinal + NADP(+) = ATP + H(+) + L-tyrosine + NADPH"}, {"i": "EC:1.2.1.101", "l": "\"L-tyrosine reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22589", "l": "4-aminobutanal => 1-pyrroline + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216043", "l": "Collagen type II binds integrin alpha10beta1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26248", "l": "geranylgeranyl diphosphate <=> diphosphate + fusicocca-2,10(14)-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001010", "l": "RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1364044", "l": "PRLR:JAK2 dimerizes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694522", "l": "Inner coat assembly and cargo binding (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46462", "l": "(22R,7alpha)-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 22R-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29687", "l": "alpha-maltoheptaose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltohexaose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14611", "l": "H(+) + keto-L-sorbose + NADPH => D-sorbitol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18342", "l": "D-xylono-1,4-lactone + H2O => D-xylonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16133", "l": "H2O + N(1)-acetylspermine + O2 = 3-aminopropanal + H2O2 + N(1)-acetylspermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18895", "l": "a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP => a flavonol 3-O-beta-D-glucoside + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19842", "l": "H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin] => CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15596", "l": "amicoumacin A 2-phosphate + H2O <=> amicoumacin A + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59159", "l": "ATP + eicosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] <=> AMP + diphosphate + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640167", "l": "RRAGA,B exchanges GDP for GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4720497", "l": "Defective ALG12 does not add mannose to the N-glycan precursor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45070", "l": "CoA + O-acyl-(R)-carnitine => (R)-carnitine + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167133", "l": "Activation of GT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25263", "l": "2-oxoglutarate + FADH2 => 2-hydroxyglutarate + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31722", "l": "11alpha-hydroxy-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-oxo-beta-amyrin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48229", "l": "a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] => a 1-lyso-glycerophospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061863", "l": "microtubule plus end polymerase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66203", "l": "O2 + pentanoyl-CoA <=> (2E)-pentenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008790", "l": "arabinose isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48782", "l": "ADP + H(+) + L-erythrulose 1-phosphate => ATP + L-erythrulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37190", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3-phosphate <=> 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.346", "l": "\"Phosphatidyl-myo-inositol dimannoside synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140656", "l": "endodeoxyribonuclease activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26532", "l": "(2E)-butenoyl-CoA + H2O => 4-hydroxybutanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16680", "l": "fluoroacetaldehyde + H2O + NAD(+) <=> fluoroacetate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19422", "l": "(R)-2-hydroxypropyl-coenzyme M => (R)-1,2-epoxypropane + coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29378", "l": "AMP + H2O <=> adenosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430180", "l": "NCK recruits WASP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450975", "l": "isocitrate <=> citrate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1297444", "l": "Binding of cAMP to HCN channels (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102643", "l": "scalarane-17alpha-19-diol synthase activity"}, {"i": "MetaCyc:RXN-15755"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66102", "l": "H2O + kynurenate + L-tyrosine => 3-(4-hydroxyphenyl)pyruvate + L-kynurenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193653", "l": "NGF homodimer binds to p75NTR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41997", "l": "globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose => globoside GalGb4Cer (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58038", "l": "8-epi-inunolide + H2O => 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5679239", "l": "ULK complex translocates to the ER (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40609", "l": "glycerol + H(+) + tetradecanoate => 1-tetradecanoyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706287", "l": "Active FLT3 binds to ABL2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805059", "l": "CK2:FACT phosphorylates TP53 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-517674", "l": "p-S158,221-HuR binds mRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939335", "l": "RNF181 polyubiquinates BCL10 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66153", "l": "acetyl-CoA + noradrenaline => CoA + H(+) + N-acetylnoradrenaline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62006", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc6S derivative + GDP + H(+) => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc6S derivative + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0042083", "l": "5,10-methylenetetrahydrofolate-dependent methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877902", "l": "Activated AR binds RUNX2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17936", "l": "a 7-hydroxyisoflavone + S-adenosyl-L-methionine <=> a 7-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.25"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005302", "l": "L-tyrosine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14301", "l": "4-pyridoxolactone + H2O = 4-pyridoxate + H(+)"}, {"i": "EC:3.1.1.27", "l": "\"4-pyridoxolactonase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26197", "l": "H2O + melamine = ammeline + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13362", "l": "CTP + H(+) + sn-glycerol 3-phosphate => CDP-glycerol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0004753", "l": "saccharopine dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866941", "l": "MID1IP1 binds THRSP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27787", "l": "2-oxoglutarate + CoA + NAD(+) => CO2 + NADH + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.12"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031854", "l": "orexigenic neuropeptide QRFP receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9006850", "l": "IL21 receptor JAK phosphorylation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12359", "l": "D-mannose 6-phosphate <=> D-fructose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237129", "l": "Acireductone is created (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66449", "l": "(E)-pent-2-en-1-ol + NADP(+) => (E)-2-pentenal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46559", "l": "5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + cholesta-5,7-dien-3beta-ol + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43258", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004972", "l": "NMDA glutamate receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0015459", "l": "potassium channel regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61567", "l": "a tetracycline + H(+) + NADPH + O2 <=> a (1S,10aS)-3-(CONH2)-1-(Me2N)-3,3a,4,6-(HO)4-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracene + CO + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49461", "l": "(2Z,4E)-2-aminomuconate + H2O => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58426", "l": "(E)-hex--2-enal + H(+) + NADPH => (E)-hex-2-en-1-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209371", "l": "LGS binds to ARM (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14005", "l": "H2O + L,L-cystathionine = 2-oxobutanoate + L-cysteine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "59.961880837850508", "identifiers": [{"i": "GO:0016627", "l": "oxidoreductase activity, acting on the CH-CH group of donors"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603801", "l": "PEX19 binds PEX3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35478", "l": "(1'S,5'S)-5'-hydroxyaverantin + NAD(+) <=> (S)-5'-oxoaverantin + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466369", "l": "NRF1:PPARGC1B binds the ATP5B promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17085", "l": "4-pyridoxate + A = 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + AH2"}, {"i": "EC:1.1.99.42", "l": "\"4-pyridoxate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19463", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+) => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977375", "l": "CR1 binds C3bBb/C4bC2a (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "64.67771801809657", "identifiers": [{"i": "GO:0015399", "l": "primary active transmembrane transporter activity"}, {"i": "TCDB:3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23883", "l": "L-histidyl-[protein] + phosphoenolpyruvate <=> N(pros)-phospho-L-histidyl-[protein] + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675921", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42802", "l": "all-trans-4,4'-diaponeurosporene + 3 FADH2 => 15-cis-4,4'-diapophytoene + 3 FAD + 3 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25753", "l": "H(+) + H2O + N,N-dihydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33493", "l": "CoA + H(+) + N-(2-hydroxyhexacosanoyl)-sphinganine => 2-hydroxyhexacosanoyl-CoA + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49373", "l": "H(+) + NADH + O2 + protodeoxyviolaceinate => H2O + NAD(+) + protoviolaceinate"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0042162", "l": "telomeric DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32905", "l": "calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => calciol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45505", "l": "[C-phycoerythrin alpha-subunit]-Cys(84)-phycoerythrobilin => (2R,3E)-phycoerythrobilin + apo-[C-phycoerythrin alpha-subunit]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15993", "l": "anthraniloyl-CoA + 2 H(+) + 2 NADPH + O2 = 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45765", "l": "H2O + L-aspartate 4-semialdehyde + NAD(+) => 2 H(+) + L-aspartate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.109", "l": "\"Iron(III) salmochelin esterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39501", "l": "(2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H2O => (3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29042", "l": "ATP + H2O + L-aspartate(out) <=> ADP + H(+) + L-aspartate(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38235", "l": "(9Z)-octadecenoyl-CoA + octadecan-1-ol = 1-O-octadecyl (9Z)-octadecenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047365", "l": "quercetin-3-sulfate 3'-sulfotransferase activity"}, {"i": "RHEA:22504", "l": "3'-phosphoadenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3'-bissulfate"}, {"i": "EC:2.8.2.26", "l": "\"Quercetin-3-sulfate 3'-sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23414", "l": "acetate + putrescine => H2O + N-acetylputrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49349", "l": "2,2-dihydroxyspirilloxanthin => 2-oxospirilloxanthin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653936", "l": "Formation of Ragulator complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15530", "l": "bis(2-ethylhexyl)phthalate + H2O => 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59355", "l": "beta-lactose + O2 <=> H2O2 + lactobiono-1,5-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25463", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + sibirene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58624", "l": "N-dodecanoyl-(2S)-hydroxyglycine = dodecanamide + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467775", "l": "Autocleavage of ESPL1 (Separase) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856189", "l": "TNFSF8 binds TNFRSF8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011543", "l": "DCA binds PDK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847968", "l": "PTEN binds FRK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381668", "l": "cAMP activates EPAC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024630", "l": "Hydroperoxy reductase reduces 7(S)-Hp-17(R)-HDHA to AT-RvD5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008127", "l": "quercetin 2,3-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41142", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34910", "l": "molybdate(in) <=> molybdate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177920", "l": "Binding of GRB2 to GAB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975633", "l": "atROL binds to RBP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39170", "l": "H(+) + malonyl-CoA + tetradecanoyl-CoA <=> 3-oxohexadecanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26073", "l": "H2O + UDP-alpha-D-glucuronate = D-glucuronate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.43"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351323", "l": "Release of 78 kDa glucose-regulated protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76426", "l": "N-atom dealkylation of caffeine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036203", "l": "taxoid 14-beta-hydroxylase activity"}, {"i": "RHEA:31971", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + NADPH + O2 = 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP(+)"}, {"i": "EC:1.14.13.146", "l": "\"Taxoid 14-beta-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-182988", "l": "Sprouty lures CBL away from EGFR (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48364", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16712", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 <=> (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9611852", "l": "ADRB3 bind ADR,NAd (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49787", "l": "chenodeoxycholoyl-CoA + taurine <=> CoA + H(+) + taurochenodeoxycholate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051720", "l": "DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674562", "l": "CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18492", "l": "cyanate + H(+) + hydrogencarbonate <=> carbamate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.2.-", "l": "\"In P-halide compounds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72631", "l": "Formation of the cap-binding eIF4F complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788622", "l": "p-Y-STATs dimerize (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14877", "l": "ATP + L-glutamate = ADP + L-glutamyl 5-phosphate"}, {"i": "EC:2.7.2.11", "l": "\"Glutamate 5-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11624", "l": "2-(hydroxyimino)propanoate + acetone = acetone oxime + pyruvate"}, {"i": "EC:2.6.3.1", "l": "\"Oximinotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388808", "l": "CD28 homodimer binds B7-2 monomer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45271", "l": "4'-hydroxyechinenone + AH2 + O2 <=> 4',4'-dihydroxyechinenone + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447226", "l": "Interleukin-12 binds Interleukin-12 receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68849", "l": "Mcm2-7 associates with the Cdt1:CDC6:ORC:origin complex, forming the pre-replicative complex (preRC) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64121", "l": "an N-(fatty acyl)-L-serine + H2O => a fatty acid + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61963", "l": "2 [Fe(II)-cytochrome b5] + a 1-O-hexadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a 1-O-(1Z-hexadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46833", "l": "4alpha-methyl-5alpha-cholest-8-en-3-one + H(+) + NADPH => 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45145", "l": "3-(methylsulfanyl)acryloyl-CoA + 2 H2O => acetaldehyde + CO2 + CoA + methanethiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12938", "l": "a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8869683", "l": "oxPL binds LBP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004776", "l": "succinate-CoA ligase (GDP-forming) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853920", "l": "VENTX binds the CDKN2A gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57629", "l": "3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate => H2O + ML-236C carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64148", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-R + CMP + H(+)"}, {"i": "RHEA:64152", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP-N-acetyl-beta-neuraminate = alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP + H(+)"}, {"i": "EC:2.4.99.22", "l": "\"N-acetylglucosaminide alpha-(2,6)-sialyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63486", "l": "CO2 + succinate + trans-4-hydroxy-L-prolyl-[protein] => 2-oxoglutarate + L-prolyl-[protein] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66458", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 [Fe(III)-cytochrome b5] + 2 H2O => 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047566", "l": "3-ketovalidoxylamine C-N-lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375151", "l": "Interaction of NCAM1 with collagens (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57469", "l": "(E)-ferulate + UDP-alpha-D-glucose => 1-O-[(E)-feruloyl]-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607721", "l": "Activation of NIK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31259", "l": "but-3-ynal + H2O + NAD(+) = 3-butynoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686587", "l": "ABL1 phosphorylates RAD52 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16456", "l": "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O <=> 2-formylbenzoate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672957", "l": "PP2A dephosphorylates KSR1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30549", "l": "(2E)-hexenoyl-CoA + H2O => (3S)-hydroxyhexanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47779", "l": "guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(1145) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616105", "l": "EGR1 binds CDK5R1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187266", "l": "SCARA5 binds ligands (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14988", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11232", "l": "3'-phosphoadenylyl sulfate + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + sulfate"}, {"i": "EC:3.6.2.2", "l": "\"Phosphoadenylylsulfatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093329", "l": "EFNBs bind SDCBP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12180", "l": "anthranilate + S-adenosyl-L-methionine = H(+) + N-methylanthranilate + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.111", "l": "\"Anthranilate N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50832", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 = 17-hydroperoxy-(7Z,10Z,13Z,15E,19Z)-docosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9626928", "l": "CREBBP binds FOXO1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24889", "l": "(R)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+) <=> D-glutamate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055100", "l": "adiponectin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445705", "l": "Release Of ADP From Myosin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-994148", "l": "LRRC16A binds F-actin capping protein (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15072", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a <=> chlorophyllide a + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201611", "l": "Caspase-mediated cleavage of Rock-1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44734", "l": "(9Z,12Z)-octadecadienoate + glycerol + H(+) => 2-(9Z,12Z-octadecadienoyl)-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592297", "l": "Full activation of MMP1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50205", "l": "(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 => (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53649", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-corvol ether A + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30933", "l": "acetate + H(+) + L,L-cystathionine => L-cysteine + O-acetyl-L-homoserine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164527", "l": "Annealing of 3'-end of unwound transfer RNA primer with genomic RNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047325", "l": "inositol tetrakisphosphate 1-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870466", "l": "RGGT:CHM binds RABs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442387", "l": "ZIP8 mediates zinc influx into cells (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26252", "l": "H(+) + levopimaradienol + NADPH + O2 <=> 2 H2O + levopimaradienal + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16042", "l": "[(1->3)-beta-D-glucosyl](n) + phosphate => [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40737", "l": "2 D-glucose + gypenoside LXXV => (20S)-ginsenoside Rb1 + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29531", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}, {"i": "EC:2.4.1.259", "l": "\"Dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141423", "l": "Binding of the MCC complex to the APC/C complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038022", "l": "G protein-coupled olfactory receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483219", "l": "PC is exchanged with PI by PITPNB (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48604", "l": "2,3-dihydroxybenzoyl-5'-AMP + holo-[EntB isochorismatase/aryl-carrier protein] = 2,3-dihydroxybenzoyl-[EntB isochorismatase/aryl-carrier protein] + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64917", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O => a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.21", "l": "\"Aspartyl aminopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64021", "l": "GTP + L-seryl-[protein] => GDP + H(+) + O-phospho-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621370", "l": "SYK autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018688", "l": "DDT 2,3-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57189", "l": "H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] => glycolate + H(+) + L-arginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190263", "l": "FGFR3b binds to FGF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685319", "l": "CX3 complex formation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.22"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022065", "l": "DSPGs are secreted (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.62", "l": "\"Subtilisin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24538", "l": "N-formyl-L-kynurenine => L-tryptophan + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928641", "l": "PAK binds RAC and bPIX (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25964", "l": "(R)-benzoin + NADP(+) = benzil + H(+) + NADPH"}, {"i": "EC:1.1.1.321", "l": "\"Benzil reductase ((R)-benzoin forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428296", "l": "IGF2BP1 binds specific RNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0034072", "l": "squalene cyclase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35065", "l": "NH4(+) + pyrazine-2-carboxylate => H2O + pyrazinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52402", "l": "3-dehydro-4-O-phospho-L-erythronate + H(+) + NADH => 4-O-phospho-D-threonate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29349", "l": "2 H(+)(out) + orotate(out) => 2 H(+)(in) + orotate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004947", "l": "bradykinin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686524", "l": "PP6-PPP6R3 dephosphorylates TERF2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5227009", "l": "ABCF1 binds EIF2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099184", "l": "structural constituent of postsynaptic intermediate filament cytoskeleton"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004049", "l": "anthranilate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.25", "l": "\"1,4-lactonase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1467209", "l": "Binding of defensins to lipid II (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51832", "l": "ATP(in) + CoA(in) + H(+)(out) + tetracosanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + tetracosanoyl-CoA(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24163", "l": "D-galactose + O2 <=> D-galacto-hexodialdose + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418850", "l": "Activation of Cdc42 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098606", "l": "selenocystathionine gamma-lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645598", "l": "RRAGC,D hydrolyzes GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23685", "l": "(S)-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] => allocryptopine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636560", "l": "Eis acetylates DUSP16 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624494", "l": "RAF1 binds p21 RAS:GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791128", "l": "Expression of LMNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4655404", "l": "SUMOylation of AURKA with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177920", "l": "Binding of GRB2 to GAB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10729", "l": "GDP-6-deoxy-alpha-D-talose + NAD(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46700", "l": "(R)-lipoate + GTP + H(+) = (R)-lipoyl-GMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37295", "l": "ATP + H2O + L-alanyl-L-threonine(out) = ADP + H(+) + L-alanyl-L-threonine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203893", "l": "Microprocessor complex cleaves pri-miRNA to pre-miRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32110", "l": "3-methoxy-4',5-dihydroxy-trans-stilbene + S-adenosyl-L-methionine <=> H(+) + pterostilbene + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25973", "l": "H2O + N(8)-acetylspermidine + O2 => 4-acetamidobutanal + H2O2 + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36219", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53064", "l": "2-methoxyestrone + UDP-alpha-D-glucuronate = 2-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37271", "l": "ATP + H2O + L-alanyl-L-glutamine(out) = ADP + H(+) + L-alanyl-L-glutamine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26202", "l": "ammeline + H(+) + H2O => ammelide + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176116", "l": "Recruitment and activation of Chk1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22459", "l": "creatine + H2O <=> sarcosine + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209143", "l": "Phosphorylation of AXN and APC by DCO (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018758", "l": "RHOH binds effectors at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31833", "l": "delta-guaiene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40557", "l": "dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+) => dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56879", "l": "(R)-N-acetyl-1-phenylethylamine + H2O <=> (R)-1-phenylethylamine + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610732", "l": "GSK3 phosphorylates p-GLI3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56876", "l": "(R)-N-acetyl-1-phenylethylamine + H2O = (R)-1-phenylethylamine + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.3", "l": "\"Uridine nucleosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58474", "l": "CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate => 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296127", "l": "Activation of voltage gated Potassium channels (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41731", "l": "(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879909", "l": "Activation of STAT5a/b by JAK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.16", "l": "\"Cathepsin H\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43479", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 <=> 10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672961", "l": "PP2A dephosphorylates inactive RAFs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57746", "l": "[protein]-dithiol + phylloquinone => [protein]-disulfide + phylloquinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-378975", "l": "Follitropin is a heterodimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63274", "l": "1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60684", "l": "(11R)-dihydroartemisinic aldehyde + H2O + NADP(+) = (11R)-dihydroartemisinate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13649", "l": "beta-D-glucose + NAD(+) = D-glucono-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3785684", "l": "Fibronectin degradation by CTSG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16007", "l": "5-dehydro-4-deoxy-D-glucarate + H2O => galactarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29289", "l": "2 H(+)(out) + L-aspartate(out) => 2 H(+)(in) + L-aspartate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50398", "l": "2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O => (2-aminobenzoyl)acetate + H(+) + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684273", "l": "3CLp cleaves pp1a (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202489", "l": "Oligomerization of Bcl10 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17011", "l": "2-succinylbenzoyl-CoA + AMP + diphosphate => 2-succinylbenzoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36851", "l": "(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102163", "l": "3-hydroxyacyl-CoA-acyl carrier protein transferase activity"}, {"i": "MetaCyc:RXN-11785"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53480", "l": "3beta-hydroxy-5alpha-androstan-17-one + H(+) + NADPH = 5alpha-androstane-3beta,17beta-diol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59193", "l": "ATP + eicosanoate + H(+) => diphosphate + icosanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46555", "l": "2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (9Z)-octadec-9-en-12-ynoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29506", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + patchoulol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34272", "l": "2-nitroimidazole + H2O => 1,3-dihydro-2H-imidazol-2-one + H(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51272", "l": "(9Z)-octadecenoyl-CoA + glycine = CoA + H(+) + N-(9Z-octadecenoyl)glycine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050187", "l": "phosphoamidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18445", "l": "H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide"}, {"i": "EC:3.5.4.10", "l": "\"IMP cyclohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651971", "l": "Defective SLC34A3 does not cotransport Pi, 2Na+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54254", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102480", "l": "5-fluorocytosine deaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419033", "l": "NCAM1 binds FGFR-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211919", "l": "CYP4F8 19-hydroxylates PGH2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448632", "l": "IL34 dimerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21409", "l": "H2O + L-phenylalanine + NAD(+) => 3-phenylpyruvate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008118", "l": "N-acetyllactosaminide alpha-2,3-sialyltransferase activity"}, {"i": "RHEA:18913", "l": "a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+)"}, {"i": "RHEA:52316", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)"}, {"i": "EC:2.4.99.6", "l": "\"N-acetyllactosaminide alpha-2,3-sialyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168445", "l": "PTP1B binds the GH receptor complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112149", "l": "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63585", "l": "2-deoxyecdysone 22-phosphate + H2O => 2-deoxyecdysone + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62355", "l": "H(+) + NADPH + notoamide E + O2 <=> H2O + NADP(+) + notoamide D"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56910", "l": "acetate + H(+) + thebaine => (7S)-O-acetylsalutaridinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390674", "l": "ADRB1 bind ADR,NAd (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12488", "l": "2-amino-2-deoxy-D-gluconate = 2-dehydro-3-deoxy-D-gluconate + NH4(+)"}, {"i": "EC:4.3.1.9", "l": "\"Glucosaminate ammonia-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58254", "l": "ADP-D-ribose + L-asparaginyl-[protein] => H2O + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57673", "l": "(+)-5-epi-aristolochene + O2 + reduced [NADPH--hemoprotein reductase] => 2beta-hydroxy-5-epi-aristolochene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25917", "l": "A + H2O + quinolin-6-ol => 6-hydroxyquinolin-2(1H)-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35894", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51070", "l": "(3S,5R,10R,12S,14S,15R,16R)-3,5,10,14,15-pentahydroxy-12,16-dimethylicosan-2-one + L-alanine => (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45863", "l": "12-hydroxyoctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(11-hydroxyheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50057", "l": "ATP + glycocholate(in) + H2O => ADP + glycocholate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61455", "l": "H(+) + NADPH + O2 + oxytetracycline <=> 11a-hydroxy-oxytetracycline + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52981", "l": "a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] => 7-oxoheptanoyl-[ACP] + a fatty aldehyde + H(+) + 2 H2O + oxidized [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63731", "l": "candesartan + UDP-alpha-D-glucuronate <=> candesartan-2-N-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2230983", "l": "LRP1:Hemopexin:heme is endocytosed (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614544", "l": "Sulfite is oxidized to sulfate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64063", "l": "(S)-phenylacetylcarbinol + NAD(+) <=> 1-phenyl-1,2-propanedione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41528", "l": "(2E)-octenoyl-[ACP] + H(+) + NADH = NAD(+) + octanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25097", "l": "ATP + dCMP <=> ADP + dCDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32298", "l": "2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH <=> 2 diphosphate + NADP(+) + squalene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15763", "l": "H(+) + L-aspartate 4-semialdehyde + NADPH => L-homoserine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69074", "l": "Formation of Processive Complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666169", "l": "Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47105", "l": "5,10-methylenetetrahydromethanopterin + glycine + H2O => 5,6,7,8-tetrahydromethanopterin + L-serine"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0015173", "l": "aromatic amino acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168046", "l": "Collagen type XII degradation by MMP12 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730892", "l": "Recruitment of VAV to p-SLP-76 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1011598", "l": "DOCKs bind to RhoGEFs (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981892", "l": "Active G alpha (z) binds RGS proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004126", "l": "cytidine deaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2995334", "l": "COX15 transforms heme O to heme A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40390", "l": "1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP <=> 1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27350", "l": "arsenate + mycothiol => arseno-mycothiol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48899", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide a <=> 3,8-divinyl protochlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617326", "l": "CALM1:4xCa2+ binds GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors and displaces ACTN2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11995", "l": "L-pipecolate + O2 <=> H(+) + H2O2 + L-1-piperideine-6-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392530", "l": "p-S400-Cot phosphorylates NIK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9686088", "l": "CASP3 cleaves GSDMD (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65376", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidyl-adenosine in mRNA + 2 S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidyl-adenosine in mRNA + H(+) + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37213", "l": "guanosine 2'-monophosphate + H(+) => 2',3'-cyclic GMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48464", "l": "ganglioside GM1b + H2O = ganglioside GA1 + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609728", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN3B (GRIN3B) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009085", "l": "DEXA:NR3C1 complex binds RUNX2 gene proximal promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381644", "l": "ER calcium channels open in response to activated PKA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10523", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose <=> 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610722", "l": "CK1 phosphorylates p-GLI3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52110", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate => 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004395", "l": "hexaprenyldihydroxybenzoate methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29821", "l": "ADP + H(+) + L-isoleucine(in) + phosphate => ATP + H2O + L-isoleucine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18112", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47922", "l": "ganglioside GA2 (d18:1(4E)/18:0) + N-acetylneuraminate => ganglioside GM2 (d18:1(4E)/18:0) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675431", "l": "PP2A dephosphorylates RAF1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.21"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649856", "l": "Oxidative damage to the AP site (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29295", "l": "aldehydo-D-galacturonate(out) + H(+)(out) = aldehydo-D-galacturonate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592316", "l": "Initial activation of proMMP1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617182", "l": "PRKACA phosphorylates PLN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2730862", "l": "Autophosphorylation of LYN kinase (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5676229", "l": "WIPIs bind PI3P (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373748", "l": "SEMA4D interacts with CD72 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10635", "l": "D-mannonate + NAD(+) <=> D-mannuronate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36948", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64136", "l": "H2O + N-(9Z-octadecenoyl)-L-asparagine = (9Z)-octadecenoate + L-asparagine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163820", "l": "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30860", "l": "dITP + H2O => dIDP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23757", "l": "D-arabinono-1,4-lactone + O2 => dehydro-D-arabinono-1,4-lactone + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35292", "l": "11-methyldodecanoyl-CoA + H(+) + malonyl-CoA => 3-oxoisopentadecanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951910", "l": "RUNX3 binds the RUNX1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23482", "l": "dimethylmaleate => 2-methylene-3-methylsuccinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37486", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-dodecanoyl-sn-glycero-3-phosphocholine <=> 1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50620", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = alpha-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}, {"i": "EC:2.4.1.343", "l": "\"UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol alpha-1,3-galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44299", "l": "2 H(+) + hexadecanoyl-CoA + malonyl-CoA + methylmalonyl-CoA <=> 4-hydroxy-5-methyl-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15834", "l": "(S)-4-hydroxymandelate + H(+) + O2 => 4-hydroxybenzaldehyde + CO2 + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482860", "l": "DLCL transports from the IM to the ER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34240", "l": "L-glutamate => 3-aminopentanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38455", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43283", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-171141", "l": "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3560802", "l": "Defective B3GAT3 does not transfer GlcA to tetrasaccharide linker (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65219", "l": "3-oxododecanoyl-CoA + H2O <=> 3-oxododecanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28442", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + dodecanoyl-[ACP] = dodecanoyl-(Kdo)2-lipid IVA + holo-[ACP]"}, {"i": "EC:2.3.1.241", "l": "\"Kdo(2)-lipid IV(A) lauroyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47043", "l": "5-taurinomethyluridine(34) in tRNA + AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] <=> 5-taurinomethyl-2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682377", "l": "LC3 de-lipidation by ATG4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66518", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8957241", "l": "TP73 tetramer translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0003697", "l": "single-stranded DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33745", "l": "an N-acylsphing-4-enine + phosphate => an N-acylsphing-4-enine 1-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51889", "l": "2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+) => 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22194", "l": "(6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide => (6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671868", "l": "Phosphorylated LEPR Binds STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33488", "l": "(4R)-hydroxysphinganine + 2-hydroxyhexacosanoyl-CoA => CoA + H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3296233", "l": "T2Rs bind bitter-tasting compounds (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855131", "l": "VLDLR:PCSK9 binds Clathrin-coated vesicles (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28653", "l": "9-riburonosylhypoxanthine + H(+) + H2O => inosine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56885", "l": "adenosine(32) in tRNA + S-adenosyl-L-methionine => 2'-O-methyladenosine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2179413", "l": "Activated PKC-alpha  activate MMP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30001", "l": "ADP + H(+) + phosphate + spermidine(in) => ATP + H2O + spermidine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22987", "l": "carbamoyl phosphate + oxamate <=> N-carbamoyl-2-oxoglycine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58805", "l": "5'-pApG-3' + H2O => 5'-ApG-3' + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22503", "l": "(E)-feruloyl-CoA + H(+) + malonyl-CoA <=> (E)-feruloylacetyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15891", "l": "L-glutamate + NH4(+) => H2O + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45281", "l": "12-(phosphooxy)octadecanoate + H2O => 12-hydroxyoctadecanoate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28411", "l": "4-(gamma-L-glutamylamino)butanal + H2O + NADP(+) => 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9733969", "l": "Bile salts dissociate from FABP6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11597", "l": "H(+) + orotidine 5'-phosphate => CO2 + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418874", "l": "Recruitment and activation of N-WASP by Cdc42 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036356", "l": "cyclic 2,3-diphosphoglycerate synthetase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912385", "l": "Phosphorylated NICD1 binds FBXW7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357432", "l": "AXL binds SRC-1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36188", "l": "1-O-alkyl-2-acyl-sn-glycerol + CDP-ethanolamine => 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17881", "l": "H2O + N-sulfo-D-glucosamine = D-glucosamine + sulfate"}, {"i": "EC:3.10.1.1", "l": "\"N-sulfoglucosamine sulfohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210277", "l": "Interaction of PECAM-1 and SHP-1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60836", "l": "a 5'-end diphospho-adenosine in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46856", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH = 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2545203", "l": "Deacetylation of cleaved cohesin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53392", "l": "2-phenylacetate + O2 + reduced [NADPH--hemoprotein reductase] = (2-hydroxyphenyl)acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.54", "l": "\"Phenylacetate 2-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110244", "l": "Excision of FapyG by OGG1 glycosylase (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58032", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47977", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33828", "l": "ergosterol => vitamin D2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109639", "l": "Formation of the closed pre-initiation complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48875", "l": "a gentamycin + GTP <=> a gentamycin 2''-phosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810076", "l": "DDO oxidizes D-Asp to OA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19299", "l": "ADP + carnosine + H(+) + phosphate => ATP + beta-alanine + L-histidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41185", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654748", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3878123", "l": "Initiation of SAHF formation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23136", "l": "a primary amine + S-adenosyl-L-methionine = a methylated primary amine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64435", "l": "H(+)(out) + L-alanyl-L-prolylglycine(out) <=> H(+)(in) + L-alanyl-L-prolylglycine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31238", "l": "(4S)-4-hydroxy-L-glutamate + 2-oxoglutarate <=> (4R)-4-hydroxy-2-oxoglutarate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28858", "l": "H(+)(in) + melibiose(in) <=> H(+)(out) + melibiose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201717", "l": "CSNK2-mediated phosphorylation of DVL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878054", "l": "HIPK2 phosphorylates RUNX1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004818", "l": "glutamate-tRNA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45594", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60683", "l": "(+)-artemisinic aldehyde + H2O + NADP(+) <=> (+)-artemisinate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879724", "l": "Expression of PPARA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354060", "l": "Translocation of RIAM to plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016989", "l": "sigma factor antagonist activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65204", "l": "(3R)-3-hydroxybutanoyl-CoA + H2O = (R)-3-hydroxybutanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41397", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine => 1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050604", "l": "taxadiene 5-alpha-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15448", "l": "H(+) + H2O + O-carbamoyl-L-serine <=> CO2 + 2 NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033835", "l": "flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603108", "l": "Defective MAOA does not oxidatively deaminate 5HT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430096", "l": "GP1b-IX-V binds filamin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50862", "l": "13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O => (9Z,12Z)-octadecadienoate + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.16"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17851", "l": "(2E)-butenoyl-CoA + H2O => (3R)-3-hydroxybutanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14424", "l": "H2O + N(2)-benzoyl-D-arginine-4-nitroanilide <=> 4-nitroaniline + H(+) + N(2)-benzoyl-D-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14883", "l": "asparagusate + H(+) + NADH => 3-sulfanyl-2-(sulfanylmethyl)propanoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21021", "l": "5-O-(1-carboxyvinyl)-3-phosphoshikimate => chorismate + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018542", "l": "2,3-dihydroxy DDT 1,2-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10795", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964550", "l": "The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds E2F1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36469", "l": "glycine + L-alanine => H2O + L-alanylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028730", "l": "Activated NTRK2 binds FRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43607", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] <=> 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20917", "l": "L-cysteine + sulfite => hydrogen sulfide + L-cysteate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10976", "l": "H(+) + NADH + O2 + quinolin-2-ol = 5,6-dihydroquinoline-2,5,6-triol + NAD(+)"}, {"i": "EC:1.14.12.16", "l": "\"2-hydroxyquinoline 5,6-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9681616", "l": "AP2 binds chlorpromazine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033769", "l": "glyceollin synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785762", "l": "IL13RA1 binds TYK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68615", "l": "Formation of ORC(1-6) complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691154", "l": "HFE binds TFRC dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614933", "l": "ACEIs bind ACE (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62160", "l": "H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate = N-(9Z-octadecenoyl) ethanolamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334164", "l": "DNMT3B:DNMT3L binds chromatin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938853", "l": "CDK6 binds RUNX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005140", "l": "interleukin-9 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696131", "l": "AOC1 deaminates Hist (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46835", "l": "4alpha-methyl-5alpha-cholest-8-en-3-one + H(+) + NADPH <=> 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016897", "l": "exoribonuclease activity, producing 3'-phosphomonoesters"}, {"i": "EC:3.1.14.-", "l": "\"Exoribonucleases producing 3'-phosphomonoesters\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708457", "l": "HM13 cleaves HMOX1 dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862733", "l": "CCR2, CCR3 bind CCL13 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77081", "l": "Formation of the CE:GMP intermediate complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18939", "l": "a carboxylate + L-homoserine lactone => an N-acyl-L-homoserine lactone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46426", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9619376", "l": "CAMK1 binds calmodulin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47500", "l": "cholate + NADP(+) = 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66032", "l": "alpha-D-mannose 1-phosphate + GDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75081", "l": "Formation of AT-AC B Complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693761", "l": "FA2H hydroxylates CERA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50241", "l": "[hyaluronan](n) => n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36048", "l": "A + D-glyceraldehyde + H2O => (R)-glycerate + AH2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36620", "l": "2-hydroxydocosanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxydocosanoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785165", "l": "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58241", "l": "H2O + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] => ADP-D-ribose + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70510", "l": "LDH tetramer oxidises LACT to PYR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20706", "l": "an N-acetyl-D-amino acid + CoA + H(+) => a D-alpha-amino acid + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14498", "l": "A + pyridoxine => AH2 + isopyridoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3262512", "l": "G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805426", "l": "CARD8 binds CASP9(1-416) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237160", "l": "MTA is cleaved and phosphorylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8856945", "l": "PP2A methylation by LCMT1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38844", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26257", "l": "dehydroabietadienol + H(+) + NADPH + O2 = dehydroabietadienal + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008494", "l": "translation activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362386", "l": "Glycosylation of Hh (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60400", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O = Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27893", "l": "3'-UMP + H2O <=> phosphate + uridine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64299", "l": "(4S,8R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,16,19-heptaen-18-one + H(+) + NADPH <=> (4S,8R,16R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,19-hexaen-18-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849908", "l": "SALM4 binds flotillin-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38856", "l": "2 [Fe(II)-cytochrome b5] + a 1,2-saturated fatty acid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (R)-2-hydroxy fatty acid + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000263", "l": "TCII:Cbl is degraded to release Cbl (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37385", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16132", "l": "NADP(+) + pyridoxine <=> H(+) + NADPH + pyridoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3341294", "l": "Superoxide reduces cytochrome c (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809254", "l": "MTMR8 binds MTMR9 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31051", "l": "(3R)-beta-leucine + H2O + NAD(+) = 4-methyl-3-oxopentanoate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.21", "l": "\"1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050348", "l": "trehalose O-mycolyltransferase activity"}, {"i": "RHEA:23472", "l": "2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose"}, {"i": "EC:2.3.1.122", "l": "\"Trehalose O-mycolyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10293", "l": "acetyl-CoA + D-glucosamine 6-phosphate => CoA + H(+) + N-acetyl-D-glucosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170116", "l": "Myt-1 mediated phosphorylation of Cyclin A:Cdc2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086083", "l": "SUMOylation of ING2 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25118", "l": "H2O + L-lysine + NAD(+) => (S)-2-amino-6-oxohexanoate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798373", "l": "MDM2 ubiquitinates DYRK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627104", "l": "XIAP binds CASP3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14644", "l": "cyanurate + H2O <=> biuret + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3451147", "l": "KAT5 HAT complex acetylates TCF4 gene at histone H4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8857686", "l": "FITM1, FITM2 bind TAGs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111970", "l": "PKC phosphorylates GRK2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43023", "l": "L,L-cystathionine <=> 2-aminoprop-2-enoate + L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851352", "l": "CCR8 binds CCL1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60279", "l": "L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429683", "l": "CERT:ceramide [ER] => ceramide [Golgi] + CERT [ER] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13919", "l": "(1R,4S)-menthone + H(+) + NADPH => (-)-menthol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.2.10", "l": "\"Lanthanide-dependent methanol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17025", "l": "NADP(+) + xylitol = H(+) + L-xylulose + NADPH"}, {"i": "EC:1.1.1.10", "l": "\"L-xylulose reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10850", "l": "ADP + an [alpha-factor](out) + H(+) + phosphate => an [alpha-factor](in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30010", "l": "ATP + H2O + L-arabinose(out) <=> ADP + H(+) + L-arabinose(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68611", "l": "Formation of ORC(1-5) complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61908", "l": "2 ATP + benzoate + L-phenylalanine + N-benzoyl-L-phenylalaninol = 2 AMP + asperphenamate + 2 diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37931", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = (10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043772", "l": "acyl-phosphate glycerol-3-phosphate acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64444", "l": "L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-methionine = 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.368", "l": "\"[Histone H3]-lysine(9) N-dimethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5660980", "l": "p-S276-RELA binds RELB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014296", "l": "RAC2 GEFs activate RAC2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56560", "l": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35685", "l": "3-oxohexadecasphinganine + H(+) + NADPH => hexadecasphinganine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41075", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66489", "l": "quillate + UDP-alpha-D-glucose => quillaic acid 28-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "77.02358060617253", "identifiers": [{"i": "GO:0008395", "l": "steroid hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381798", "l": "PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000247", "l": "Endosomal CBLIF:Cbl translocates to lysosome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39791", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247844", "l": "WNT ligands traffic to the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54437", "l": "2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 => a (4S)-2,3-dehydroflavan-3,4-diol + CO2 + H(+) + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5600598", "l": "Defective CYP11B2 does not oxidise 11DCORST (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018545", "l": "NAD(P)H nitroreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954117", "l": "E2F6:TFDP1 binds EPC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47447", "l": "3-oxo-(7Z-hexadecenoyl)-CoA + CoA <=> (5Z)-tetradecenoyl-CoA + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004502", "l": "kynurenine 3-monooxygenase activity"}, {"i": "MetaCyc:KYNURENINE-3-MONOOXYGENASE-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050092", "l": "meso-tartrate dehydrogenase activity"}, {"i": "MetaCyc:MESO-TARTRATE-DEHYDROGENASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158860", "l": "SULT1A1 dimer sulfonates NHABP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59961", "l": "N(alpha)-acetyl-D-methionine => N(alpha)-acetyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201634", "l": "Caspase-mediated cleavage of FADK 1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352268", "l": "Cleavage of Satb1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008884", "l": "glutathionylspermidine amidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928645", "l": "EPHB:NMDAR binds TIAM1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39619", "l": "(2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H(+) + NADPH = (14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65556", "l": "globoside GalGb4Cer + H2O = an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48488", "l": "all-trans-retinol--[retinol-binding protein] + NAD(+) = all-trans-retinal--[retinol-binding protein] + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54774", "l": "1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + diphosphate => ATP + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24123", "l": "H(+) + leukotriene E4 + NADPH + O2 <=> 20-hydroxy-leukotriene E4 + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44000", "l": "2-oxoglutarate + 3-methylhexadecanoyl-CoA + O2 = 2-hydroxy-3-methylhexadecanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40517", "l": "3-sulfolactaldehyde + dihydroxyacetone phosphate => 6-deoxy-6-sulfo-D-fructose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65846", "l": "ADP(in) + phosphate(out) => ADP(out) + phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426151", "l": "SREBP1A,2 binds the SQLE promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10845", "l": "oxaloacetate + pyridoxamine => L-aspartate + pyridoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31802", "l": "4-amino-5-aminomethyl-2-methylpyrimidine + H2O <=> 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0052631", "l": "sphingolipid delta-8 desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665686", "l": "FMNL1 binds CDC42:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661425", "l": "BIL:ALB dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32925", "l": "glycerol + H(+) + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phospho-(1'-sn-glycerol)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019772", "l": "low-affinity IgG receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-398185", "l": "LARG binds plexin B1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3245898", "l": "TCN1 binds Cbl in the circulation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54504", "l": "all-trans-hexaprenyl diphosphate = beta-hexaprene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14692", "l": "4-chlorophenylacetate + NADH + O2 <=> 3,4-dihydroxyphenylacetate + chloride + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47683", "l": "D-galactosamine 6-phosphate + H2O <=> D-tagatose 1-phosphate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56399", "l": "[(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate trimer + [(3R)-hydroxybutanoate](n-3) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.25"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75862", "l": "Fall Back to Closed Pre-initiation Complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40099", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31880", "l": "(S)-2,3-epoxysqualene => beta-seco-amyrin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875817", "l": "MET phosphorylates STAT3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53679", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 <=> 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49611", "l": "2-glutathionyl-2-methylbut-3-enal + H2O + NAD(+) <=> 2-glutathionyl-2-methylbut-3-enoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30182", "l": "oxalate + oxidized 2[4Fe-4S]-[ferredoxin] <=> 2 CO2 + reduced 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9619376", "l": "CAMK1 binds calmodulin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31781", "l": "13-cis-retinol + a fatty acid + H(+) => an all-trans-retinyl ester + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45327", "l": "H2O + N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine <=> H(+) + N-tetracosanoyl-sphing-4-enine + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35096", "l": "choline => acetaldehyde + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49455", "l": "a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H2O <=> 6-sulfo-D-quinovose + a 1,2-diacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48162", "l": "epoxypheophorbide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 3 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161775", "l": "ALOX12 oxidises LTA4 to LXA4/B4 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22996", "l": "H2O2 + L-ascorbate = 2 H2O + L-dehydroascorbate"}, {"i": "EC:1.11.1.11", "l": "\"L-ascorbate peroxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706287", "l": "Active FLT3 binds to ABL2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57702", "l": "5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine => a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27408", "l": "a ubiquinone + H2O + pyruvate <=> a ubiquinol + acetate + CO2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008663", "l": "2',3'-cyclic-nucleotide 2'-phosphodiesterase activity"}, {"i": "EC:3.1.4.16", "l": "\"2',3'-cyclic-nucleotide 2'-phosphodiesterase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052855", "l": "ADP-dependent NAD(P)H-hydrate dehydratase activity"}, {"i": "EC:4.2.1.136", "l": "\"ADP-dependent NAD(P)H-hydrate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57993", "l": "(20S)-ginsenoside C-K + UDP-alpha-D-glucose => (20S)-ginsenoside F2 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804099", "l": "HMGB1 binds LTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943279", "l": "GGT dimers hydrolyse GSH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.21", "l": "\"Inositol-hexakisphosphate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11522", "l": "(-)-menthyl beta-D-glucoside + H(+) + UDP => (-)-menthol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654569", "l": "Activated FGFR1 binds FRS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043826", "l": "sulfur oxygenase reductase activity"}, {"i": "MetaCyc:RXN-8226"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428749", "l": "Activated TP receptor binds G-proten Gq (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420117", "l": "VEGFR2 autophosphorylates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15495", "l": "AH2 + nitrous oxide => A + H2O + N2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25813", "l": "H2O + N(1)-acetylspermidine + O2 => 3-acetamidopropanal + H2O2 + putrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33064", "l": "H(+) + NAD(+) + 2 reduced [2Fe-2S]-[putidaredoxin] => NADH + 2 oxidized [2Fe-2S]-[putidaredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14191", "l": "N-formyl-D-kynurenine => D-tryptophan + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701488", "l": "Active ALK phosphorylates JAK3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015042", "l": "trypanothione-disulfide reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53015", "l": "2,5-dichlorohydroquinone + 2 glutathione <=> chloride + chlorohydroquinone + glutathione disulfide + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18450", "l": "A + arsenite + H2O => AH2 + arsenate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.18", "l": "\"Dolichyl-diphosphooligosaccharide--protein glycotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51198", "l": "chloride(in) + Na(+)(in) + serotonin(in) => chloride(out) + Na(+)(out) + serotonin(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018641", "l": "6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050559", "l": "copalyl diphosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0042123", "l": "glucanosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50624", "l": "acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O = a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56335", "l": "5'-triphosphoadenylyl-(2'->5')-adenosine + H2O <=> AMP + ATP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12338", "l": "fumarate + glycolate => carboxymethoxysuccinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848436", "l": "PTK6 phosphorylates CDKN1B (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51491", "l": "archaetidylserine + H(+) <=> archaetidylethanolamine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706304", "l": "Active FLT3 binds to GRAP2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21832", "l": "3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine = 3',5-dihydroxy-3,4',7-trimethoxyflavone + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.83", "l": "\"3,7-dimethylquercetin 4'-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63035", "l": "a fatty acylamide + H2O <=> a fatty acid + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24009", "l": "ATP + hypotaurocyamine => ADP + H(+) + N(omega)-phosphohypotaurocyamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47728", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP-alpha-D-mannose = (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10698", "l": "AMP + diphosphate + long-chain fatty acyl-[mycocerosate synthase] => a long-chain fatty acid + ATP + holo-[mycocerosate synthase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052751", "l": "GDP-mannose hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158959", "l": "urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42914", "l": "5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798044", "l": "BTG2 binds CCR4-NOT complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "80.155824608458104", "identifiers": [{"i": "GO:0016895", "l": "exodeoxyribonuclease activity, producing 5'-phosphomonoesters"}, {"i": "EC:3.1.11.-", "l": "\"Exodeoxyribonucleases producing 5'-phosphomonoesters\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615501", "l": "MIR132 gene expression is stimulated by p-S133-CREB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46045", "l": "(3Z)-octenoyl-CoA => (2E)-octenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655193", "l": "KIAA0101 double monoubiquitination (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-877281", "l": "PIAS1 binds p-STAT1 dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28948", "l": "H(+)(out) + L-arabinose(in) => H(+)(in) + L-arabinose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47260", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "81.790986234327661", "identifiers": [{"i": "GO:0030555", "l": "RNA modification guide activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22982", "l": "dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] => a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26495", "l": "chloride + FADH2 + L-tryptophan + O2 => 7-chloro-L-tryptophan + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59095", "l": "[(1->3)-alpha-D-glucosyl](n) + sucrose <=> [(1->3)-alpha-D-glucosyl](n+1) + D-fructose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102545", "l": "phosphatidyl phospholipase B activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036435", "l": "K48-linked polyubiquitin modification-dependent protein binding"}, {"i": "REACT:R-HSA-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453356", "l": "PGYB dimer, b form + 2 AMP <=> PGYB b dimer:AMP complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46022", "l": "[pyruvate, water dikinase]-phosphate + AMP + H(+) => [pyruvate, water dikinase] + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30239", "l": "n a quinone + n H(+) + n hydrogen sulfide = n a quinol + n sulfur"}, {"i": "EC:1.8.5.4", "l": "\"Bacterial sulfide:quinone reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237129", "l": "Acireductone is created (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19077", "l": "H2O + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] = 3-deoxyglucosone + L-lysyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18916", "l": "a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983427", "l": "Expression of peptide bound class I MHC on cell surface (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46279", "l": "(S)-malate + H(+) <=> (S)-lactate + CO2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103067", "l": "4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60853", "l": "a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50211", "l": "cortisol + NAD(+) <=> cortisone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045544", "l": "gibberellin 20-oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50041", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031698", "l": "beta-2 adrenergic receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25407", "l": "(S)-2-ethyl-2-hydroxy-3-oxobutanoate <=> (R)-3-hydroxy-3-methyl-2-oxopentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58937", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADH => all-trans-lycopaoctaene + 2 diphosphate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15549", "l": "S-methyl-5-thio-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O"}, {"i": "EC:4.2.1.109", "l": "\"Methylthioribulose 1-phosphate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21997", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + an acyl-CoA => a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047369", "l": "succinate-hydroxymethylglutarate CoA-transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17102", "l": "H2O + O-acyl-(R)-carnitine => (R)-carnitine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018567", "l": "styrene dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071795", "l": "K11-linked polyubiquitin modification-dependent protein binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047804", "l": "cysteine-S-conjugate beta-lyase activity"}, {"i": "RHEA:18121", "l": "an S-substituted L-cysteine + H2O = a thiol + NH4(+) + pyruvate"}, {"i": "EC:4.4.1.13", "l": "\"Cysteine-S-conjugate beta-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9654533", "l": "KRAS4B recycles to the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44794", "l": "H(+) + menaquinol-12 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-12 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12203", "l": "2'-deoxymugineate + 2-oxoglutarate + O2 <=> CO2 + mugineate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24425", "l": "2 glutathione + L-dehydroascorbate => glutathione disulfide + L-ascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35151", "l": "4-hydroxy-3-nitrophenylacetaldehyde + H2O + NAD(+) = (3-nitro-4-oxidophenyl)acetate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11585", "l": "L-ornithine => D-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010488", "l": "UDP-galactose:N-glycan beta-1,3-galactosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47214", "l": "2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55419", "l": "biochanin A + UDP-alpha-D-glucose <=> biochanin A 7-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390846", "l": "D2D3,4 bind to DA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951644", "l": "Release of mature NEDD8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.46"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050190", "l": "phosphoglucokinase activity"}, {"i": "RHEA:13377", "l": "alpha-D-glucose 1-phosphate + ATP = ADP + alpha-D-glucose 1,6-bisphosphate + H(+)"}, {"i": "EC:2.7.1.10", "l": "\"Phosphoglucokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166220", "l": "FA anion diffuses laterally to UCP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31814", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + viridiflorene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49180", "l": "a bacteriochlorophyllide d + S-adenosyl-L-methionine = a bacteriochlorophyllide c + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.333", "l": "\"Bacteriochlorophyllide d C-20 methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052716", "l": "hydroquinone:oxygen oxidoreductase activity"}, {"i": "RHEA:11276", "l": "4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O"}, {"i": "EC:1.10.3.2", "l": "\"Laccase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52941", "l": "chenodeoxycholate + UDP-alpha-D-glucuronate => chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16382", "l": "L-arabinitol + NAD(+) => H(+) + L-xylulose + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874078", "l": "PTK2 autophosphorylates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11609", "l": "[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA => [(2->8)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.22"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41968", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) = a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57711", "l": "(E)-coniferaldehyde + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-4-trans-coniferyl aldehyde + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31621", "l": "dTDP-3-dehydro-6-deoxy-alpha-D-galactose + L-glutamate => 2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9693111", "l": "RHOF auto-activates (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34167", "l": "2,6-dihydroxypseudooxynicotine + H2O = 2,6-dihydroxypyridine + 4-(methylamino)butanoate + H(+)"}, {"i": "EC:3.7.1.19", "l": "\"2,6-dihydroxypseudooxynicotine hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2509827", "l": "ITPA hydrolyses ITP to IMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9632039", "l": "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57305", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP => glycolate + GMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42055", "l": "9-cis-retinol + NAD(+) <=> 9-cis-retinal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52465", "l": "17beta-estradiol + UDP-alpha-D-glucuronate => 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12256", "l": "L-arogenate + NAD(+) = CO2 + L-tyrosine + NADH"}, {"i": "EC:1.3.1.43", "l": "\"Arogenate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187332", "l": "Cytosolic CMs translocate to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65671", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontenoyl)-sphing-4-enine <=> a diacylglycerol + an N-(32-(9Z,12Z-octadecadienoyloxy)-dotriacontenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070611", "l": "histone methyltransferase activity (H3-R2 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52198", "l": "1-aci-nitro-2-(phenyl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17311", "l": "a phenol + acetate + H(+) => a phenyl acetate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27840", "l": "2'-aminobiphenyl-2,3-diol + NAD(+) => 9H-carbazole + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017058", "l": "FH1 domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37260", "l": "(2S)-2-aminobutanoate + H2O + NAD(+) => 2-oxobutanoate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19970", "l": "hydroxylamine + O2 => H(+) + H2O + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733969", "l": "Bile salts dissociate from FABP6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-741395", "l": "CARD9 binds RIP2 (and NOD2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005550", "l": "pheromone binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33264", "l": "L-phenylalanine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-phenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53818", "l": "L-cysteine + succinate => hydrogen sulfide + O-succinyl-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46453", "l": "2 L-leucyl-tRNA(Leu) => cyclo(L-leucyl-L-leucyl) + 2 H(+) + 2 tRNA(Leu)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31601", "l": "(Z)-2-methylureidoacrylate + FMN + H(+) + H2O + NAD(+) => FMNH2 + NADH + O2 + thymine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16373", "l": "(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)"}, {"i": "EC:2.7.1.33", "l": "\"Pantothenate kinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047250", "l": "4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58544", "l": "2 L-ascorbate + N-tetradecanoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-tetradecanoyl-(2S)-hydroxyglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47955", "l": "[prokaryotic ubiquitin-like protein]-C-terminal-L-glutamine + H2O <=> [prokaryotic ubiquitin-like protein]-C-terminal-L-glutamate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52260", "l": "a 7(1),7(1)-dihydroxybacteriochlorophyllide c = a bacteriochlorophyllide e + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41589", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9022314", "l": "HIPK2 phosphorylates MECP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61853", "l": "campesterol + UDP-alpha-D-glucose => campesteryl 3-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170149", "l": "Translocation of active Cdc25C to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102605", "l": "cyclooctat-9-en-5,7-diol C18-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981539", "l": "C3b binds to cell surface (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72621", "l": "Ribosomal scanning  (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15601", "l": "(E)-cinnamoyl-CoA + (R)-3-phenyllactate = (E)-cinnamate + (R)-3-phenyllactoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32310", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> H2O + leukotriene A4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36393", "l": "cholesta-5,24-dien-3beta-ol + H(+) + NADPH => cholesterol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005252", "l": "open rectifier potassium channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031894", "l": "DPAn-3 maresins translocate from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853310", "l": "Activated FGFR3 fusions bind FRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65294", "l": "3-oxopentanoate + 2 AMP + 4 H(+) + 4 phosphate => 2 ATP + butan-2-one + 3 H2O + hydrogencarbonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60848", "l": "a 5'-end diphospho-guanosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] = a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375160", "l": "NCAM1 binds to ATP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51984", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.39", "l": "\"Hydroxyjasmonate sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47407", "l": "(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) <=> 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635861", "l": "NUMB:ITCH binds GLI1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61545", "l": "ent-kaur-16-en-19-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.3.-", "l": "\"Hydrolyzing S-glycosyl compounds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952128", "l": "RUNX3 binds TP53 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.23", "l": "\"Rhamnogalacturonan endolyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654422", "l": "Activated FGFR4 binds FRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25462", "l": "diphosphate + sibirene => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209257", "l": "Phosphorylated REL-68 forms a complex with PCAF at its target gene and activates transcription (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59810", "l": "D-tyrosine => L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045512", "l": "interleukin-26 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17387", "l": "H(+) + NADH + taurine => H2O + hypotaurine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65254", "l": "diphosphate + verruculide C => (2E,6E)-farnesyl diphosphate + 6-hydroxymellein"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35374", "l": "2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A <=> (beta-L-Ara4N)2-(Kdo)2-lipid A + 2 di-trans,octa-cis-undecaprenyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173739", "l": "Spontaneous hydrolysis of C3 thioester (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40177", "l": "(2E)-octenoyl-CoA + H2O2 => O2 + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19141", "l": "all-trans-retinol = 11-cis-retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444792", "l": "Calmodulin-bound CaMKII-gamma enters the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16184", "l": "3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine <=> 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679816", "l": "SIGMAR1 binds dextromethorphan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55460", "l": "11-hydroxyferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 11-hydroxysugiol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36634", "l": "D-ribulose 1,5-bisphosphate + O2 <=> (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21982", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) => 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102561", "l": "D-ribose 2,5-bisphosphate 2-phosphohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41037", "l": "1-O-hexadecyl-2-acetyl-3-hexadecanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43340", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70427", "l": "PGM:Mg2+ isomerise G1P to G6P (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707516", "l": "FeHM dissociates from MetHb (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66614", "l": "methylmalonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] => N(6)-carboxybiotinyl-L-lysyl-[protein] + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60630", "l": "A + H2O + xi-progoitrin => AH2 + gluconapin + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17382", "l": "(9Z,12Z)-octadecadienoate => (9Z,11E)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26526", "l": "a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O"}, {"i": "EC:4.2.1.119", "l": "\"Enoyl-CoA hydratase 2\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551683", "l": "SUMOylation of TOPORS with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190698", "l": "Transport of connexins to the ER-Golgi intermediate compartment (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30026", "l": "L-alanine + pyridoxal 5'-phosphate <=> pyridoxamine 5'-phosphate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205244", "l": "Recruitment of CBL to KIT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852306", "l": "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58751", "l": "desmethylnectriapyrone + S-adenosyl-L-methionine <=> H(+) + nectriapyrone + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59987", "l": "an N(2)-acyl-L-glutamine + H2O <=> a carboxylate + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58451", "l": "N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50716", "l": "dimethyl sulfone + FMNH2 + O2 = FMN + formaldehyde + 2 H(+) + H2O + methanesulfinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2473596", "l": "Collagen type I degradation by MMP15 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351871", "l": "Caspase-mediated cleavage of Z0-2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46591", "l": "calciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> calcidiol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22196", "l": "(9Z,12Z)-octadecadienoyl-CoA + AH2 + O2 = (6Z,9Z,12Z)-octadecatrienoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49791", "l": "chenodeoxycholoyl-CoA + glycine <=> CoA + glycochenodeoxycholate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390329", "l": "Dephosphorylation of AKT by PP2A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730884", "l": "Phosphorylation of NTAL by p-SYK/Lyn (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28813", "l": "2,3-dioxo-L-gulonate(out) + Na(+)(out) => 2,3-dioxo-L-gulonate(in) + Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698265", "l": "Enhanced autophagosome formation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57897", "l": "2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2 => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37364", "l": "5 AH2 + 2 H(+) + heme b + 4 O2 => 5 A + beta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60257", "l": "A + H2O + N(6)-methyl-L-lysyl(4)-[histone H3] => AH2 + formaldehyde + L-lysyl(4)-[histone H3]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004962", "l": "endothelin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605259", "l": "Active FLT3 binds FYN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782820", "l": "USP17 deubiquitinates SUDS3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32700", "l": "(2E,6E)-farnesyl diphosphate => beta-sesquiphellandrene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046910", "l": "pectinesterase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15705", "l": "2 a ubiquinone + H2O + phenylacetyl-CoA = 2 a ubiquinol + phenylglyoxylyl-CoA"}, {"i": "EC:1.17.5.1", "l": "\"Phenylacetyl-CoA dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18810", "l": "L-alanine + oxomalonate => aminomalonate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59205", "l": "docosanoyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] => AMP + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1297333", "l": "Association of Acrosin Heavy and Light Chain (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51580", "l": "a fatty acid(out) + ATP(in) + CoA(in) + H(+)(out) = a fatty acyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25721", "l": "(E)-6-(methylsulfanyl)hexanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-trihomomethionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16780", "l": "ATP + H2O + K(+)(out) <=> ADP + H(+) + K(+)(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610760", "l": "GLI1 is degraded by the proteasome after ubiquitination by ITCH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602473", "l": "Autocatalytic activation of MMP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372843", "l": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13239", "l": "D-glucosamine 6-phosphate + L-glutamate => D-fructose 6-phosphate + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57188", "l": "H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] = glycolate + H(+) + L-arginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8954082", "l": "E2F6 binds the PRC1 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-164840", "l": "ADP and Pi bind to ATPase (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784735", "l": "PCSK9:LDLR bind to Clathrin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48034", "l": "(2E)-2-methylbut-2-enoyl-CoA + FADH2 => (2S)-2-methylbutanoyl-CoA + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66911", "l": "acetyl-CoA + 20 H(+) + 9 malonyl-CoA + 13 NADPH + S-adenosyl-L-methionine <=> 9 CO2 + 10 CoA + 7 H2O + 13 NADP(+) + S-adenosyl-L-homocysteine + soppiline A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37415", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17528", "l": "biuret + H2O <=> NH4(+) + urea-1-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624953", "l": "ARL13B binds INPP5E (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39217", "l": "hexacosanoyl-CoA + NADP(+) => (2E)-hexacosenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21332", "l": "acetyl-CoA + D-glucosamine = CoA + H(+) + N-acetyl-D-glucosamine"}, {"i": "EC:2.3.1.3", "l": "\"Glucosamine N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166220", "l": "FA anion diffuses laterally to UCP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44281", "l": "2 H(+) + 2 malonyl-CoA + octadecanoyl-CoA => 4-hydroxy-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047187", "l": "deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase activity"}, {"i": "RHEA:20393", "l": "holo-[citrate lyase ACP] + S-acetylphosphopantotheine = acetyl-[citrate lyase ACP] + D-pantetheine 4'-phosphate"}, {"i": "EC:2.3.1.49", "l": "\"Deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43859", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) <=> a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57149", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29919", "l": "alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP = ADP + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638004", "l": "RP2 binds ARL3:GTP:UNC119B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51063", "l": "5alpha-androst-1-ene-3,17-dione + A <=> AH2 + androsta-1,4-diene-3,17-dione"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050540", "l": "2-aminomuconate deaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50513", "l": "acetyl-CoA + N-terminal L-cysteinyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21210", "l": "L-serine + phosphate => H2O + O-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40763", "l": "(20S)-ginsenoside Re + H2O = (20S)-ginsenoside Rg1 + L-rhamnopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38714", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecylglycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6786650", "l": "DDHD1,2 hydrolyse PA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36832", "l": "2 caldariellaquinol + n H(+)(in) + O2 => 2 caldariellaquinone + n H(+)(out) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029460", "l": "PAK1 phosphorylates LIMK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58630", "l": "FADH2 + H2O + NADP(+) + rifamycin SV hemiaminal => FADH2-C4alpha-hydroperoxide + H(+) + NADPH + rifamycin SV"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48492", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + UDP-alpha-D-galactose = 1,2-di-(9Z,12Z-octadecadienoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47921", "l": "ganglioside GM2 (d18:1(4E)/18:0) + H2O => ganglioside GA2 (d18:1(4E)/18:0) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52202", "l": "(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O => 1-aci-nitro-2-(phenyl)ethane + glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32000", "l": "(2E,6E)-farnesyl diphosphate => bicyclogermacrene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141367", "l": "Myristoylation of tBID by NMT1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36373", "l": "2-oxobutanoate + H(+) + NADH => (2S)-hydroxybutanoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55441", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + maniladiol + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29534", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32426", "l": "(1R,4R)-dihydrocarvone + A <=> (R)-carvone + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31791", "l": "H2O + tuberculosinyl diphosphate = (13S)-edaxadiene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51328", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 = 10-hydroperoxy-(8Z,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59511", "l": "fumarate + L-cysteinyl-[protein] <=> S-(2-succinyl)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14402", "l": "chlordecone alcohol + NADP(+) => chlordecone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265456", "l": "NPC1L1 binds ezetimibe (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39056", "l": "22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022065", "l": "DSPGs are secreted (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010290", "l": "chlorophyll catabolite transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870466", "l": "RGGT:CHM binds RABs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22297", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate => (1R,2R,3R)-prephytoene diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51957", "l": "(E)-2-methylpropanal oxime => (Z)-2-methylpropanal oxime"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38346", "l": "(20S)-ginsenoside Rd + H2O <=> (20S)-ginsenoside Rg3 + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809793", "l": "MTMR2 binds SBF2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58009", "l": "(20S)-ginsenoside F1 + UDP-alpha-D-glucose => (20S)-ginsenoside Rg1 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51189", "l": "nitric oxide + superoxide => peroxynitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18206", "l": "AH2 + O2 + progesterone => 11alpha-hydroxyprogesterone + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66531", "l": "ATP + O-(5'-adenylyl)-L-tyrosyl-[protein] <=> diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47463", "l": "3-oxo-(5Z-tetradecenoyl)-CoA + CoA <=> (3Z)-dodecenoyl-CoA + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23197", "l": "3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine => 3 AMP + 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54582", "l": "5'-end-(RNA) + ADP + H(+) => 5'-dephospho-(RNA) + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3159253", "l": "MMAB transfers adenosyl group from ATP to cob(I)alamin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56834", "l": "2,3,6-trichlorohydroquinone + 2 glutathione => 2,6-dichlorohydroquinone + chloride + glutathione disulfide + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-377640", "l": "Autophosphorylation of SRC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621411", "l": "EGR2 and SREBF2(1-484) dimer bind HMGCR gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57920", "l": "4-phosphooxy-L-aspartyl-tRNA(Asn) + NH4(+) = H(+) + L-asparaginyl-tRNA(Asn) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1467269", "l": "Beta-defensins bind microbial membranes causing disruption (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203553", "l": "eNOS binds NOSIP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56036", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106376", "l": "2-hydroxyphytanoyl-CoA lyase activity"}, {"i": "RHEA:25355", "l": "2-hydroxyphytanoyl-CoA = 2,6,10,14-tetramethylpentadecanal + formyl-CoA"}, {"i": "EC:4.1.2.n2", "l": "\"2-hydroxyphytanoyl-CoA lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34175", "l": "2-hydroxybenzoyl-CoA + malonyl-CoA = 4-hydroxycoumarin + CO2 + 2 CoA"}, {"i": "EC:2.3.1.208", "l": "\"4-hydroxycoumarin synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097263", "l": "eoxin E4 synthase activity"}, {"i": "REACT:R-HSA-2161868", "l": "EXD4 is converted to EXE4 by DPEP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140684", "l": "histone H3-tri/dimethyl-lysine-9 demethylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30427", "l": "(2E,6E)-farnesyl diphosphate = (+)-germacrene D + diphosphate"}, {"i": "EC:4.2.3.77", "l": "\"(+)-germacrene D synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032863", "l": "CDK5 phosphorylates NTRK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10584", "l": "4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH = 3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+)"}, {"i": "EC:2.3.1.170", "l": "\"6'-deoxychalcone synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59830", "l": "inosine + L-homocysteine => H2O + S-inosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46909", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA => 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + a 1,2-diacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33005", "l": "(+)-artemisinic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-amorpha-4,11-diene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18800", "l": "a 3'-hydroxy,5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 3',5'-dihydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13486", "l": "2-oxoglutarate + S-(4-bromophenyl)-L-cysteine => 3-((4-bromophenyl)sulfanyl)-2-oxopropanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47980", "l": "dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose = dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374173", "l": "AGT(34-41) binds to AGTR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53105", "l": "4-hydroxyestrone + S-adenosyl-L-methionine => 4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159773", "l": "Furin cleaves pro-protein S to protein S (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928607", "l": "p-EPHs bind VAV2,3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45888", "l": "12-methyltridecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(11-methyldodecyl)-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641205", "l": "RSPO:LGR binds ZNRF3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205289", "l": "Autophosphorylation of KIT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22330", "l": "diphosphate + thiamine phosphate => 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29198", "l": "(S)-dihydroorotate + a menaquinone <=> a menaquinol + orotate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49473", "l": "trans-4-hydroxy-L-prolyl-[protein] + UDP-beta-L-arabinofuranose => H(+) + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160931", "l": "Disassembly of tight junctions (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55458", "l": "2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + sugiol => ferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62307", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine <=> (+)-premalbrancheamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28604", "l": "(1E,2S)-2-methylbutanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-isoleucine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59700", "l": "D-cellopentaono-1,5-lactone + H2O = D-cellopentaonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814096", "l": "ARL1:GTP binds SCOC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61753", "l": "steviolbioside + UDP-alpha-D-glucose => H(+) + rebaudioside B + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047207", "l": "1,2-beta-fructan 1F-fructosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660665", "l": "Caspase-8 binds MALT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49244", "l": "NAD(+) + resolvin E1 = 18-oxo-resolvin E1 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42015", "l": "cortisol + NAD(+) <=> 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54296", "l": "GTP + L-tyrosyl-[protein] = diphosphate + O-(5'-guanylyl)-L-tyrosyl-[protein]"}, {"i": "EC:2.7.7.n6", "l": "\"Guanine phosphate-protein transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2317332", "l": "PIP3 recruits AKT to the membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39230", "l": "(2E)-octacosenoyl-CoA + H(+) + NADPH <=> NADP(+) + octacosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63600", "l": "H2O + neocasomorphin = L-isoleucine + neocasomorphin-(1-5)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25012", "l": "N-hydroxy-L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5631885", "l": "PRDX1 overoxidizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49218", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + phosphate => 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951977", "l": "Acetylated RUNX3 binds to BRD2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0019107", "l": "myristoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41064", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-398040", "l": "Gbeta:gamma activation of PLC beta (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40411", "l": "1,2-dihexadecanoyl-sn-glycero-3-CDP + myo-inositol = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43465", "l": "H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14671", "l": "(2R)-3-phosphoglycerate + 2 H(+) + NADPH => D-glyceraldehyde 3-phosphate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-197963", "l": "DHFR2 reduces FOLA to DHF (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17392", "l": "D-arabinitol + NAD(+) <=> D-ribulose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54237", "l": "1,2-didecanoyl-sn-glycerol + CDP-choline => 1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66821", "l": "ATP + H2O + Mn(2+)(in) => ADP + H(+) + Mn(2+)(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200406", "l": "CPT1A,B transfers PALM to CAR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187332", "l": "Cytosolic CMs translocate to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50148", "l": "a fatty acid ethyl ester + H2O = a fatty acid + ethanol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029536", "l": "Expression of UGT1A3  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37350", "l": "(R)-lactate + ATP + D-alanine <=> ADP + D-alanyl-(R)-lactate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23552", "l": "2-methylpropane-1,2-diol + NAD(+) = 2-hydroxy-2-methylpropanal + H(+) + NADH"}, {"i": "EC:1.1.1.400", "l": "\"2-methyl-1,2-propanediol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16246", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071172", "l": "dihydromonapterin reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43260", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008901", "l": "ferredoxin hydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29835", "l": "D-galactonate(in) + H(+)(in) = D-galactonate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938356", "l": "RMB14 binds RUNX2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37549", "l": "3-dehydro-D-glucose 6-phosphate + H(+) + NADH => D-glucose 6-phosphate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41931", "l": "(2E)-octadecenoyl-[ACP] + H(+) + NADPH <=> NADP(+) + octadecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16894", "l": "pyridine + S-adenosyl-L-methionine => N-methylpyridinium + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43800", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211960", "l": "CYP2U1 19-hydroxylates ARA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52851", "l": "5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine <=> 5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47580", "l": "ganglioside GT3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GT2 (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2574845", "l": "AJUBA binds centrosome-associated AURKA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60181", "l": "ATP + D-fructose(out) + H2O => ADP + D-fructose(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983153", "l": "E1 mediated ubiquitin activation (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38404", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O => (9Z,12Z)-octadecadienoate + 1,3-di-(9Z,12Z)-octadecadienoylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624133", "l": "ARL3:GTP binds the UNC119B complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11373", "l": "ATP + L-aspartate + NH4(+) => AMP + diphosphate + H(+) + L-asparagine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28836", "l": "citrate(out) + succinate(in) => citrate(in) + succinate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36498", "l": "alpha-D-glucose + ATP <=> ADP + alpha-D-glucose 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30185", "l": "H(+) + keto-D-tagaturonate + NADH => L-galactonate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008736", "l": "L-fucose isomerase activity"}, {"i": "RHEA:17233", "l": "L-fucose = L-fuculose"}, {"i": "EC:5.3.1.25", "l": "\"L-fucose isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4167511", "l": "HLCS biotinylates ACACB (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004450", "l": "isocitrate dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730835", "l": "Autophosphorylation of PKC-theta (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37473", "l": "CoA + H(+) + N-isovaleryl-L-homoserine lactone + S-methyl-5'-thioadenosine => 3-methylbutanoyl-CoA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43355", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol(in) <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23893", "l": "3-nitropropanoate + NADP(+) => 3-nitroacrylate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212642", "l": "L-Glutamine transport into neurons (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41641", "l": "3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA => 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50846", "l": "(5S,6S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => (5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4411402", "l": "Activation of NLK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55020", "l": "5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O = 5,6-diaminouracil + D-ribose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43787", "l": "adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015390", "l": "purine-specific nucleoside:sodium symporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032810", "l": "sterol response element binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48266", "l": "H(+) + S-sulfanyl-L-cysteinyl-[SoxY protein] + sulfate => H2O + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36412", "l": "cholesta-5,7-dien-3beta-ol + hnu => calciol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14612", "l": "D-sorbitol + NADP(+) <=> H(+) + keto-L-sorbose + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66457", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41547", "l": "8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine <=> 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876789", "l": "CARNMT1 methylates CARN to Anserine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61970", "l": "2 [Fe(III)-cytochrome b5] + a 1-O-(1Z,9Z-octadecadienyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H2O => 2 [Fe(II)-cytochrome b5] + a 1-O-(9Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46773", "l": "1-octadecanoyl 2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617838", "l": "CDKN1A gene transcription is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9653514", "l": "USP17L2 deubiquitinates RCE1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683888", "l": "LMCD1 binds GATA6, sequestering it (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29803", "l": "ATP + H2O + L-valine(in) = ADP + H(+) + L-valine(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9646685", "l": "Aggresome dissociates from dynein and microtubule (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222128", "l": "NOC2L binds TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18641", "l": "a menaquinone + H2 = a menaquinol"}, {"i": "EC:1.12.5.1", "l": "\"Hydrogen:quinone oxidoreductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451345", "l": "DSCAM binds DCC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13392", "l": "glutaryl-CoA + 2 H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050224", "l": "prunasin beta-glucosidase activity"}, {"i": "RHEA:16489", "l": "(R)-prunasin + H2O = D-glucose + mandelonitrile"}, {"i": "EC:3.2.1.118", "l": "\"Prunasin beta-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25703", "l": "N-hydroxy-L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.21"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62662", "l": "(2'R)-atrovenetin => 2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990919", "l": "proteasome-nuclear membrane anchor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46801", "l": "H(+) + Na(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => Na(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66903", "l": "acetyl-CoA + L-tryptophan + malonyl-CoA <=> CO2 + 2 CoA + cyclo-acetoacetyl-L-tryptophan + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.2", "l": "\"Dipeptidyl-peptidase II\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21918", "l": "2 [Fe(II)cytochrome c550] + an aldehyde + 2 H(+) + NH4(+) => 2 [Fe(III)cytochrome c550] + an aliphatic amine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4167511", "l": "HLCS biotinylates ACACB (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35796", "l": "2'-deamino-2'-hydroxyneamine + UDP-alpha-D-kanosamine => H(+) + kanamycin A + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40855", "l": "FAD + H(+) + undecanoyl-CoA = FADH2 + trans-2-undecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43063", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate <=> beta-D-glucose 1-phosphate + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64474", "l": "(2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate + S-adenosyl-L-homocysteine => (2R)-2-hydroxy-4-(methylsulfanyl)butanoate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51475", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24187", "l": "4,5-dihydroxyphthalate + H(+) <=> 3,4-dihydroxybenzoate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57296", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O = a 2'-deoxyguanosine in DNA + glycolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622357", "l": "PIKE-L interaction with UNC5B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57173", "l": "(S)-2-hydroxyglutarate + NAD(+) => 2-oxoglutarate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14213", "l": "ATP + beta-D-fructose 1-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)"}, {"i": "EC:2.7.1.56", "l": "\"1-phosphofructokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42712", "l": "S-adenosyl-L-methionine + uridine(54) in tRNA = 5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.35", "l": "\"tRNA (uracil(54)-C(5))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951500", "l": "Dissociation of CANX from nonameric complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433488", "l": "Phosphorylation of SHP2 by SFKs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15966", "l": "1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28739", "l": "Cd(2+)(in) + H(+)(out) = Cd(2+)(out) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60521", "l": "2 H2O + L-cystine-bis-glycine => 2 glycine + L-cystine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51739", "l": "L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41026", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + octadecanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-octadecanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15237", "l": "2 [Fe(III)-cytochrome c2] + NADPH = 2 [Fe(II)-cytochrome c2] + H(+) + NADP(+)"}, {"i": "EC:1.6.2.5", "l": "\"NADPH--cytochrome-c2 reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59351", "l": "D-maltobiono-1,5-lactone + H2O <=> D-maltobionate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35587", "l": "FMN + H2O = phosphate + riboflavin"}, {"i": "EC:3.1.3.102", "l": "\"FMN hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9656893", "l": "OPN1MW binds 11cRAL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4332359", "l": "Active calmodulin binds CAMK2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798374", "l": "DYRK2 phosphorylates TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15479", "l": "5beta-scymnol sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 5beta-scymnol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174124", "l": "Dephosphorylation of phospho-Cdh1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28888", "l": "H(+)(in) + L-serine(in) => H(+)(out) + L-serine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19774", "l": "NADP(+) + sn-glycerol 3-phosphate => D-glyceraldehyde 3-phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64423", "l": "H(+)(out) + L-alanyl-L-proline(out) <=> H(+)(in) + L-alanyl-L-proline(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139918", "l": "Phosphorylation of BIM by JNK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018556", "l": "2,2',3-trihydroxybiphenyl dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9700120", "l": "PTN and MDK bind to PTPRZ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869683", "l": "oxPL binds LBP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44129", "l": "(9E)-octadecenoyl-CoA + hexadecan-1-ol => CoA + hexadecanyl (9E)-octadecenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635843", "l": "GLI translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55529", "l": "H(+) + H2O + L-tyrosine + O2 => (4-hydroxyphenyl)acetaldehyde + CO2 + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604675", "l": "NICD4 binds to TACC3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-377640", "l": "Autophosphorylation of SRC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424485", "l": "Release of p-PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37310", "l": "glycyl-L-asparagine + H2O <=> glycine + L-asparagine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5333671", "l": "CLCAs self cleave (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368065", "l": "Expression of NPAS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.23"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58161", "l": "ent-copalyl diphosphate => diphosphate + dolabradiene"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903777", "l": "melibiose binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11444", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate"}, {"i": "EC:3.1.6.9", "l": "\"Chondro-4-sulfatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66401", "l": "ATP + glutathione(in) + glycocholate(in) + H2O => ADP + glutathione(out) + glycocholate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41655", "l": "aclacinomycin S + dTDP-2-deoxy-beta-L-fucose <=> 2-deoxy-alpha-L-fucosylaclacinomycin S + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10629", "l": "phosphate + tRNA(n+1) => a ribonucleoside 5'-diphosphate + tRNA(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391933", "l": "EP3 receptor can bind PGE2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31258", "l": "(2S)-2-acetolactate <=> 3-hydroxy-3-methyl-2-oxobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55205", "l": "5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine => 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65023", "l": "L-ornithine + succinyl-CoA <=> CoA + H(+) + N(2)-succinyl-L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9006873", "l": "IL21 receptor STAT binding (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209566", "l": "TRAF6 is auto-ubiquitinated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39137", "l": "(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O2 => (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862733", "l": "CCR2, CCR3 bind CCL13 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57867", "l": "indole-3-carbonyl nitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxy-indole-3-carbonyl nitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70510", "l": "LDH tetramer oxidises LACT to PYR (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37784", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793666", "l": "MDM2 translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28908", "l": "3-(3-hydroxyphenyl)propanoate(in) + H(+)(in) => 3-(3-hydroxyphenyl)propanoate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62867", "l": "7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + S-adenosyl-L-methionine <=> 9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44216", "l": "12-hydroxyoctadecanoate + ATP + CoA = 12-hydroxyoctadecanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64829", "l": "3-hydroxybenzyl alcohol + acetyl-CoA => 3-hydroxy-benzyl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51171", "l": "(R)-adrenaline + H2O + O2 <=> 3,4-dihydroxymandelaldehyde + H2O2 + methylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5684006", "l": "KPNA2 translocates NBN to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28864", "l": "H(+)(out) + lactose(in) => H(+)(in) + lactose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52389", "l": "ATP + D-threonate => 4-O-phospho-D-threonate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663127", "l": "p-BMAL1:p-CLOCK,NPAS2 binds F7 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399978", "l": "Protein kinase C, alpha type phosphorylates MARCKS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050429", "l": "calcium-dependent phospholipase C activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63007", "l": "(11Z,14Z)-eicosadienamide + H2O <=> (11Z,14Z)-eicosadienoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16839", "l": "a carboxylate + AMP + 2 H(+) => 5'-acylphosphoadenosine + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "72.787515020653174", "identifiers": [{"i": "GO:0019239", "l": "deaminase activity"}, {"i": "REACT:R-HSA-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004501", "l": "ecdysone 20-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.10"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038048", "l": "dynorphin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43090", "l": "5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine => 5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50086", "l": "ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out) => ATP + H2O + taurolithocholate 3-sulfate(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004819", "l": "glutamine-tRNA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25175", "l": "L-citrulline + methylamine => H2O + N(omega)-methyl-L-arginine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140608", "l": "cysteine-type endopeptidase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40613", "l": "2,3-dihexanoyl-sn-glycerol + H(+) + hexanoate => H2O + trihexanoylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867344", "l": "OMA1 hydrolyses OPA1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-350769", "l": "trans-Golgi Network Coat Activation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5195402", "l": "CDK1 phosphorylates LPIN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514854", "l": "CDK1 phosphorylates condensin I (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694294", "l": "E pentamer is transported to the Golgi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173725", "l": "C9 binds C5b:C6:C7:C8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10403", "l": "L-glutamine + pyruvate <=> 2-oxoglutaramate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.275", "l": "\"Gibberellin A(9) O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54788", "l": "[LarE protein]-L-cysteine + ATP + pyridinium-3,5-dicarboxylate mononucleotide = [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide"}, {"i": "RHEA:54892", "l": "[LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide = [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide"}, {"i": "EC:4.4.1.37", "l": "\"Pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021406", "l": "NOTCH3 coactivator complex binds PBX1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51312", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53664", "l": "(2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + NH4(+) = H(+) + 2 H2O + pyridinestrone carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814096", "l": "ARL1:GTP binds SCOC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23394", "l": "n a ribonucleoside 5'-phosphate + n H(+) => (nucleoside 5'-monophosphate)n + (n-1) H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027562", "l": "Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694529", "l": "Ubiquination of protein E (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58846", "l": "(6E)-8-oxogeranial + H(+) + NADH => (6E)-8-hydroxygeranial + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106348", "l": "U2 snRNA adenosine m6 methytransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15135", "l": "2-oxoglutarate + H(+) + NADH + NH4(+) => H2O + L-glutamate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26173", "l": "1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA => CoA + H(+) + mycothiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382096", "l": "Formation of NR-NCOR Corepressor Complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20735", "l": "[protein]-dithiol + [thioredoxin]-disulfide <=> [protein]-disulfide + [thioredoxin]-dithiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.55"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55138", "l": "D-alanyl-5'-AMP + diphosphate => ATP + D-alanine + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042497", "l": "triacyl lipopeptide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381644", "l": "ER calcium channels open in response to activated PKA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602472", "l": "Defective IRAK4 does not form a complex with MyD88 within the TLR5 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9681616", "l": "AP2 binds chlorpromazine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31052", "l": "(3R)-beta-leucine + H2O + NAD(+) => 4-methyl-3-oxopentanoate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782820", "l": "USP17 deubiquitinates SUDS3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13527", "l": "(1R,4R,5R)-5-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin] => (1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17985", "l": "4-(trimethylamino)butanal + H2O + NAD(+) = 4-(trimethylamino)butanoate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.47", "l": "\"4-trimethylammoniobutyraldehyde dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39465", "l": "(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O => (3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36907", "l": "(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + malonyl-CoA = (13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708466", "l": "BACH1 translocates from the nucleoplasm to the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047334", "l": "diphosphate-fructose-6-phosphate 1-phosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23146", "l": "2 H(+) + N-acetyl-D-glucosaminate + NADH => H2O + N-acetyl-alpha-D-glucosamine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63691", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004332", "l": "fructose-bisphosphate aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56708", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.171", "l": "\"Beta-amyrin 16-alpha-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40232", "l": "(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0140083", "l": "ATP-dependent protein-DNA unloading activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043214", "l": "ABC-type bacteriocin transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27433", "l": "2 glutathione amide + NAD(+) = glutathione amide disulfide + H(+) + NADH"}, {"i": "EC:1.8.1.16", "l": "\"Glutathione amide reductase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016630", "l": "protochlorophyllide reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45406", "l": "1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013985", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432295", "l": "GPVI binds Fyn and Lyn (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2423785", "l": "CR:atREs binds apoE and HSPG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23718", "l": "(2E)-dodecenoyl-CoA => (3Z)-dodecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3095889", "l": "MMACHC reduces Cbl (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5634228", "l": "TRAF1 is cleaved by caspases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39873", "l": "1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine => 3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13579", "l": "a long chain fatty alcohol + a long-chain fatty acid + H(+) => a wax ester + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54823", "l": "a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine <=> a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60567", "l": "2-deoxy-D-glucose + ATP <=> 2-deoxy-D-glucose 6-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016499", "l": "orexin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357445", "l": "PAK1-3 dimer disassociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797961", "l": "CHDH oxidises Cho to BETALD (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14368", "l": "2 H(+) + H2O + N-carbamoyl-L-aspartate <=> CO2 + L-aspartate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050008", "l": "isopiperitenone delta-isomerase activity"}, {"i": "MetaCyc:ISOPIPERITENONE-DELTA-ISOMERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56573", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose => globoside Gb3Cer + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38665", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) => a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57680", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a flavone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.19.76", "l": "\"Flavone synthase II\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54831", "l": "dimethylamine + H(+) + NADPH + O2 <=> formaldehyde + H2O + methylamine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1606583", "l": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250498", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043888", "l": "(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.59"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987043", "l": "IL22RA1 binds JAK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43000", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate"}, {"i": "EC:4.2.3.151", "l": "\"Pentamethylcyclopentadecatrienol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13963", "l": "ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate => ATP + H2O + Mg(2+) + protoporphyrin IX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14688", "l": "A + a primary alcohol <=> AH2 + an aldehyde"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008818", "l": "cobalamin 5'-phosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871366", "l": "p-Y281,292-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32836", "l": "4-(trimethylamino)butanoate(in) => 4-(trimethylamino)butanoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61205", "l": "L-arginyl-[protein] + L-cysteinyl-[protein] + methylglyoxal => H(+) + 2 H2O + N(5)-[4-(S-L-cysteinyl-[protein])-5-methyl-1H-imidazol-2-yl]-L-ornithinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-169719", "l": "Secreted CD14 binds LPS (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784959", "l": "BPHL hydrolyses VACV to ACV (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211224", "l": "Association of DFF40 with DFF45 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45963", "l": "24,25-dihydrolanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28832", "l": "D-gluconate(in) + H(+)(in) => D-gluconate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022897", "l": "proton-dependent peptide secondary active transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789208", "l": "HOCl-induced glycosaminoglycan fragmentation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17445", "l": "H2 + 2 oxidized [2Fe-2S]-[ferredoxin] = 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.12.7.2", "l": "\"Ferredoxin hydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684801", "l": "p-Y7-CLEC1B dimer:PDPN binds SYK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56067", "l": "3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose <=> 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.119"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54144", "l": "2 2-oxoglutarate + 5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 O2 = 5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 CO2 + H2O + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26102", "l": "(2R)-homocitrate => cis-homoaconitate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72095", "l": "Internal Methylation of mRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4411373", "l": "NLK translocates to nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190141", "l": "ALAD binds to Pb2+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47357", "l": "an octanoate ester + H2O => an aliphatic alcohol + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42442", "l": "H(+) + iminosuccinate + NADH => L-aspartate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161588", "l": "Delta12-PGJ2 is dehydrated to 15d-PGJ2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13455", "l": "adenosine 3',5'-bisphosphate + H(+) + quercetin 3-sulfate => 3'-phosphoadenylyl sulfate + quercetin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58200", "l": "2-oxoglutarate + 6-aminohexanoate = 6-oxohexanoate + L-glutamate"}, {"i": "EC:2.6.1.116", "l": "\"6-aminohexanoate aminotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65196", "l": "H2O + NAD(+) + S-(2-aminoethyl)-L-cysteine = H(+) + NADH + NH4(+) + S-(acetaldehyde)-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36616", "l": "2-hydroxyoctadecanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxyoctadecanoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61932", "l": "(S)-miconazole(in) + ATP + H2O = (S)-miconazole(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022886", "l": "channel-forming ionophore activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45186", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + H2O => 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58778", "l": "H(+) + NADPH + pyridine-3-carbaldehyde => NADP(+) + pyridine 3-methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46636", "l": "5beta-dihydrotestosterone + NADP(+) = H(+) + NADPH + testosterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66942", "l": "12 CO2 + 12 CoA + 8 H2O + 12 NADP(+) + S-adenosyl-L-homocysteine + soppiline B => acetyl-CoA + 22 H(+) + 11 malonyl-CoA + 12 NADPH + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41017", "l": "1-O-hexadecyl-2-acetyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-179417", "l": "Multiubiquitination of Nek2A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62494", "l": "AMP + diphosphate + L-arginyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32276", "l": "4-(phosphooxy)-L-threonine + NAD(+) => 3-amino-2-oxopropyl phosphate + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66543", "l": "A + cholesta-5,7-dien-3beta-ol + H2O <=> AH2 + cholesta-5,7-dien-3beta,25-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5334794", "l": "FABPs bind LCFAs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45429", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine => H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77094", "l": "Formation of cap binding complex (CBC) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043864", "l": "indoleacetamide hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41984", "l": "NAD(+) + propan-2-ol = acetone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53836", "l": "a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-acyl-alpha-D-glucosamine = a UDP-2-N,3-O-bis((3R)-3-hydroxyacyl)-alpha-D-glucosamine + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400434", "l": "FFAR1 binds fatty acids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34312", "l": "4-nitrocatechol + NADH + O2 => 2-hydroxy-1,4-benzoquinone + H2O + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3132753", "l": "Pancreatic proteases degrade TCN1:Cbl (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944257", "l": "Association of procollagen type XXIV (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40754", "l": "(9Z)-octadecenoate + 1-hexadecanoylglycerone 3-phosphate <=> 1-(9Z)-octadecenoylglycerone 3-phosphate + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444527", "l": "FPR is a receptor for formyl peptides (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12849", "l": "H2O + O-phospho-L-seryl-[myosin light chain] = L-seryl-[myosin light chain] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37137", "l": "1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40356", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + ATP => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211219", "l": "Translocation of caspase-3 to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047701", "l": "beta-L-arabinosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52210", "l": "H2O + methyl formate + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin] => alachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51967", "l": "2-methylpropanenitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2-methylpropanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050698", "l": "proteoglycan sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19111", "l": "1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose + H(+) => 1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59106", "l": "beta-D-glucosyl-(1->3)-O-chenodeoxycholate + dolichyl phosphate + H(+) => chenodeoxycholate + dolichyl beta-D-glucosyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48164", "l": "epoxypheophorbide a + H2O = H(+) + red chlorophyll catabolite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218820", "l": "Src kinases phosphorylate VAV (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033847", "l": "O-phosphoserine sulfhydrylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950737", "l": "IL23R binds JAK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13444", "l": "H2O + L-cysteate <=> H(+) + NH4(+) + pyruvate + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610733", "l": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733973", "l": "Bile salts bind FABP6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55349", "l": "all-trans-retinol => 9-cis-retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9640167", "l": "RRAGA,B exchanges GDP for GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20789", "l": "NAD(+) + phosphate => ADP-D-ribose 1''-phosphate + H(+) + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64563", "l": "butan-2-ol + NAD(+) <=> butan-2-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909724", "l": "Recruitment of IFNAR1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52241", "l": "2 H2O + 2 Mn(2+) + O2 => 4 H(+) + 2 MnO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696465", "l": "USP45 deubiquitinates ERCC1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28774", "l": "(2E)-hexadecenoyl-CoA <=> (9Z)-hexadecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419334", "l": "Melatonin receptors can bind melatonin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54130", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP => 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424476", "l": "Activation of RAC1 by VAV2/3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10259", "l": "[(1->4)-6-phospho-alpha-D-glucosyl](n) + n ATP + n H2O <=> [(1->4)-3,6-bisphospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5483229", "l": "HHAT G287V doesn't palmitoylate Hh-Np (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11671", "l": "[(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O <=> [(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807585", "l": "BPI binds LPS on the bacterial surface (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665998", "l": "MKL1 binds SRF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202127", "l": "eNOS synthesizes NO (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009974", "l": "zeinoxanthin epsilon hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62643", "l": "[mycoredoxin]-L-dithiol + a hydroperoxide <=> [mycoredoxin]-L-disulfide + an alcohol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50966", "l": "NH4(+) + uridine(8) in tRNA => cytidine(8) in tRNA + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34007", "l": "cholesta-5,7,24-trien-3beta-ol + S-adenosyl-L-methionine = ergosta-5,7,24(28)-trien-3beta-ol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709360", "l": "H2O2 reduces MetHb (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28329", "l": "H2O + wogonin 7-O-beta-D-glucuronate <=> D-glucuronate + H(+) + wogonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445705", "l": "Release Of ADP From Myosin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30016", "l": "alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12271", "l": "2-oxoglutarate + putrescine <=> 1-pyrroline + H2O + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66252", "l": "ATP + CoA + IC-asc-C7 = AMP + diphosphate + IC-asc-C7-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27477", "l": "2-oxoglutarate + O2 + thebaine = CO2 + formaldehyde + neopinone + succinate"}, {"i": "EC:1.14.11.31", "l": "\"Thebaine 6-O-demethylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641206", "l": "RSPOs bind LGRs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18285", "l": "an N-acyl-D-aspartate + H2O = a carboxylate + D-aspartate"}, {"i": "EC:3.5.1.83", "l": "\"N-acyl-D-aspartate deacylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46171", "l": "ATP + CoA + pentanoate <=> AMP + diphosphate + pentanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022399", "l": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786114", "l": "IL13:IL13RA:TYK2 binds IL4R:JAK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17709", "l": "4-hydroxybenzoate + all-trans-nonaprenyl diphosphate = 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42653", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine => diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57252", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP = glycolate + GTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9017491", "l": "RHOJ GEFs activate RHOJ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-606289", "l": "New CENPA-containing nucleosomes are deposited at the centromere (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35358", "l": "3-hydroxyisopentadecanoyl-CoA <=> (2E)-13-methyltetradecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46869", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli) => a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46654", "l": "5beta-dihydroepitestosterone + NADP(+) => epitestosterone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592362", "l": "Activation of proMMP7 by MMP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.120"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2484822", "l": "Kinetochore assembly (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22367", "l": "L-quinate + NAD(+) <=> 3-dehydroquinate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42385", "l": "4,4'-diaponeurosporenal + H2O + NAD(+) => 4,4'-diaponeurosporenoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24215", "l": "5-(2-hydroxyethyl)-4-methylthiazole + ATP <=> 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28254", "l": "(3Z)-hex-3-en-1-ol + acetyl-CoA = (3Z)-hex-3-en-1-yl acetate + CoA"}, {"i": "EC:2.3.1.195", "l": "\"(Z)-3-hexen-1-ol acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59052", "l": "D-lysine + H(+) = cadaverine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44155", "l": "1D-myo-inositol 2-phosphate + H2O <=> myo-inositol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199298", "l": "AKT phosphorylates CREB1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17632", "l": "alpha,alpha-trehalose(in) <=> alpha,alpha-trehalose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204434", "l": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983300", "l": "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20786", "l": "ADP-D-ribose + L-arginine => H2O + N(omega)-(ADP-D-ribosyl)-L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30530", "l": "H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate <=> ADP + ATP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981355", "l": "RASA1 binds RAS:GTP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16436", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787567", "l": "TRIT1 transfers dimethylallyl group to adenosine-37 of tRNA(Ser) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34473", "l": "acryloyl-CoA + H(+) + NADH => NAD(+) + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27479", "l": "CO2 + formaldehyde + neopinone + succinate => 2-oxoglutarate + O2 + thebaine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29449", "l": "glycolate(out) => glycolate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17037", "l": "indole-3-ethanol + NADP(+) = H(+) + indole-3-acetaldehyde + NADPH"}, {"i": "EC:1.1.1.191", "l": "\"Indole-3-acetaldehyde reductase (NADPH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1370505", "l": "PRLR is phosphorylated at Ser-349 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0032029", "l": "myosin tail binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165179", "l": "Formation of TSC1:TSC2 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018557", "l": "1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48101", "l": "L-arginyl-[protein] + S-adenosyl-L-methionine => H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43745", "l": "ATP + cytidine(34) in tRNA(Ile2) + L-lysine => AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0016640", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor"}, {"i": "EC:1.4.2.-", "l": "\"With a cytochrome as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196773", "l": "COASY phosphorylates DP-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19054", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O => H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5228992", "l": "ROCK1,ROCK2 are activated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353268", "l": "Binding of Pol zeta complex to a DNA template containing lesions (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23764", "l": "diphosphate + L-serine = H(+) + O-phospho-L-serine + phosphate"}, {"i": "EC:2.7.1.80", "l": "\"Diphosphate--serine phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58671", "l": "3-deoxyfructose + NADP(+) <=> 3-deoxyglucosone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0070697", "l": "activin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2299677", "l": "SCARA5:ligand is endocytosed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23587", "l": "7,8-dihydropteroate + ATP + L-glutamate <=> 7,8-dihydrofolate + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42305", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60816", "l": "2-oxoglutarate + gibberellin A14 aldehyde + O2 = CO2 + gibberellin A14 + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60060", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42463", "l": "dibenzofuran + H(+) + NADH + O2 <=> biphenyl-2,2',3-triol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56974", "l": "(R)-methylmalonate semialdehyde + H(+) + NADH => (R)-3-hydroxy-2-methylpropanoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40984", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O => (9Z)-octadecenoate + 1,3-dihexadecanoylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10278", "l": "1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP => 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24881", "l": "A + L-sorbopyranose <=> 1-dehydro-L-sorbose + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38984", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O => 1-tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034567", "l": "chromate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46512", "l": "2 [Fe(II)-cytochrome b5] + an N-(1,2-saturated acyl)sphinganine + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + an N-[(2'R)-hydroxyacyl]sphinganine + H2O"}, {"i": "EC:1.14.18.7", "l": "\"Dihydroceramide fatty acyl 2-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034291", "l": "canonical holin activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53917", "l": "an acyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-acyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.4.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29965", "l": "H(+)(out) + inosine(out) => H(+)(in) + inosine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964619", "l": "PAK1 binds ARHGEF6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203700", "l": "eNOS translocation from Golgi to Caveolae (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38285", "l": "itaconyl-CoA + succinate => itaconate + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48688", "l": "H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine = D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl"}, {"i": "EC:3.4.17.13", "l": "\"Muramoyltetrapeptide carboxypeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981658", "l": "Complement factor I binds C4BP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687097", "l": "p-S857 NCOA3 binds ETV4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60582", "l": "18-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53385", "l": "5,10-methylenetetrahydromethanopterin + NAD(+) => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005297", "l": "proline:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26494", "l": "chloride + FADH2 + L-tryptophan + O2 = 7-chloro-L-tryptophan + FAD + 2 H2O"}, {"i": "EC:1.14.19.9", "l": "\"Tryptophan 7-halogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50518", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-threonyl-[protein] => acetyl-CoA + N-terminal L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030698", "l": "5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28532", "l": "phosphate + xanthosine => H2O + XMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205682", "l": "Parkin promotes the ubiquitination of mitochondrial substrates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45676", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45322", "l": "H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine => H2O + N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043560", "l": "insulin receptor substrate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15778", "l": "1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O => 1-guanidino-1-deoxy-scyllo-inositol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15562", "l": "S-adenosyl-L-methionine + sterigmatocystin => 8-O-methylsterigmatocystin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0052744", "l": "phosphatidylinositol monophosphate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867041", "l": "EGFR phosphorylates EPS15 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0034595", "l": "phosphatidylinositol phosphate 5-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20268", "l": "2-oxoglutarate + L-proline + O2 <=> cis-3-hydroxy-L-proline + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60657", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-2,3-cyclic phosphate + choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23667", "l": "A + a (2R)-2-hydroxycarboxylate <=> a 2-oxocarboxylate + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43495", "l": "7(1)-hydroxychlorophyll a + NADP(+) <=> chlorophyll b + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211904", "l": "CYP4F12 18-hydroxylates ARA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5667111", "l": "PARK2 K63-Ubiquitinates SNCAIP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33166", "l": "beta-nicotinamide D-riboside(in) <=> beta-nicotinamide D-riboside(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070699", "l": "type II activin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444606", "l": "T1R2/T1R3 dimer is a sweet taste receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65348", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA = 3-oxochol-4,6-dien-24-oyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58031", "l": "5 (S)-methylmalonyl-CoA + a medium-chain fatty acyl-CoA + 32 H(+) + 5 malonyl-CoA + 22 NADPH <=> a mycoketide-CoA + 10 CO2 + 10 CoA + 11 H2O + 22 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.109", "l": "\"Endogalactosaminidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49395", "l": "20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,23,24-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030777", "l": "(S)-scoulerine 9-O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.20"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64814", "l": "CoA + H(+) + S-(2-acetamidoethyl)-homocysteine => acetyl-CoA + S-(2-aminoethyl)-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2130706", "l": "MHC class II antigen processing (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33710", "l": "ATP + L-threonine <=> ADP + H(+) + O-phospho-L-threonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10895", "l": "(2R,3S)-3-isopropylmalate + NAD(+) <=> (2S)-2-isopropyl-3-oxosuccinate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28945", "l": "glycine betaine(out) => glycine betaine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622572", "l": "NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24126", "l": "11-cis-retinal => all-trans-retinal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51923", "l": "a quinone + AH2 <=> A + a quinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54763", "l": "ATP + H(+) + pyridinium-3,5-dicarboxylate mononucleotide <=> 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004736", "l": "pyruvate carboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11940", "l": "2 H(+) + H2O + L-citrulline = CO2 + L-ornithine + NH4(+)"}, {"i": "EC:3.5.1.20", "l": "\"Citrullinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932351", "l": "KEAP1 facilitates ubiquitination of NFE2L2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14691", "l": "3,4-dihydroxyphenylacetate + chloride + NAD(+) => 4-chlorophenylacetate + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029456", "l": "RAC1 and CDC42 activate PAK1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701003", "l": "BAP1 binds BRCA1:BARD1 heterodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18582", "l": "ethanolamine + H2O + O2 => glycolaldehyde + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42672", "l": "hercynine + L-gamma-glutamyl-L-cysteine + O2 = H2O + L-gamma-glutamyl-hercynylcysteine S-oxide"}, {"i": "EC:1.14.99.50", "l": "\"Gamma-glutamyl hercynylcysteine S-oxide synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52595", "l": "deoxycholoyl-CoA + NAD(+) <=> 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48666", "l": "12,20-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62529", "l": "2 [Fe(II)cytochrome c] + digoxin + 3 H(+) => 2 [Fe(III)cytochrome c] + dihydrodigoxin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8960973", "l": "RLBP1:11cRAL dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57512", "l": "chlorobenzene + H(+) + NADH + O2 = (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+)"}, {"i": "EC:1.14.12.26", "l": "\"Chlorobenzene dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64939", "l": "dGTP + H2O <=> dGDP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857555", "l": "EGFR phosphorylates GPNMB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004643", "l": "phosphoribosylaminoimidazolecarboxamide formyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49977", "l": "butanoyl-CoA + H2O => adenosine 3',5'-bisphosphate + butanoyl-4'-phosphopantetheine + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44704", "l": "a 2,3-saturated acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65552", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O = an N-acyl-sphingoid base + lactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54265", "l": "2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2 => (3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975180", "l": "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917696", "l": "Cargo Sequestration (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9696268", "l": "RND3 binds effectors (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38644", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-381109", "l": "IRE1 binds IRE1 forming dimer (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50405", "l": "(2-aminobenzoyl)acetate + H(+) + S-octanoyl-L-cysteinyl-[PqsC protein] => 1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.124"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33981", "l": "D-glucose + DIBOA => DIBOA beta-D-glucoside + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11735", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoraflavanone B <=> H(+) + H2O + leachianone G + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18529", "l": "3-methylbutanol + NAD(+) = 3-methylbutanal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17987", "l": "4-(trimethylamino)butanoate + 2 H(+) + NADH => 4-(trimethylamino)butanal + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32591", "l": "(4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O = (3R,6S)-6-hydroxy-3,7-dimethyloctanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48307", "l": "a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose <=> a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71050", "l": "Trimerization of the FASL:FAS receptor complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14559", "l": "D-glucose + vomilenine => H2O + raucaffricine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204850", "l": "Interaction of Tie2 and Dok-2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9615348", "l": "AGT(34-41) binds to AGTR2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036174", "l": "butane monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44489", "l": "3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26547", "l": "beta-alaninamide + H2O => beta-alanine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418581", "l": "Activated P2Y purinoceptor 1 binds G-protein Gq (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53675", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 <=> 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphoethanolamine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19252", "l": "glyoxylate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419153", "l": "5-phosphoribosylamine + glycine + ATP <=> 5-phosphoribosylglycinamide (GAR) + adenosine 5'-diphosphate + orthophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654399", "l": "Activated FGFR2 binds FRS2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30802", "l": "(3S)-3-hydroxybutanoyl-CoA + NAD(+) <=> acetoacetyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29402", "l": "H2O + ITP <=> diphosphate + H(+) + IMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2089971", "l": "Secretion of collagens (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0005153", "l": "interleukin-8 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534365", "l": "Slo3 Potassium Transport (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187575", "l": "Ubiquitination of phospho-p27/p21 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49805", "l": "2-methylpropan-1-amine + FMNH2 + O2 => FMN + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690873", "l": "ACO1 binds 4Fe-4S (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49088", "l": "FAD + H(+) + H2O + squalene = FADH2 + hydroxysqualene"}, {"i": "EC:1.17.8.1", "l": "\"Hydroxysqualene dehydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14627", "l": "[(1->4)-alpha-D-glucosyl](n+1) + [(1->6)-alpha-D-glucosyl](n) => [(1->4)-alpha-D-glucosyl](n) + [(1->6)-alpha-D-glucosyl](n+1)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30721", "l": "2-methyl-3-oxobutanoyl-CoA + CoA => acetyl-CoA + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15352", "l": "L-glutamate + N(2)-acetyl-L-ornithine <=> L-ornithine + N-acetyl-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16949", "l": "myo-inositol + NAD(+) = H(+) + NADH + scyllo-inosose"}, {"i": "EC:1.1.1.18", "l": "\"Inositol 2-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16575", "l": "(R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate => 2-oxoglutarate + 4-(phosphooxy)-L-threonine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004412", "l": "homoserine dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651773", "l": "LIG1 binds POLB at long-patch BER site (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17136", "l": "ATP + L-seryl-[tyrosine-3-monooxygenase] <=> ADP + H(+) + O-phospho-L-seryl-[tyrosine-3-monooxygenase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849094", "l": "ARHGAP35 binds RASA1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27462", "l": "D-glycero-alpha-D-manno-heptose 1-phosphate + GTP + H(+) => diphosphate + GDP-D-glycero-alpha-D-manno-heptose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852337", "l": "GTSE1 binds TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12962", "l": "acetoacetate + butanoyl-CoA => acetoacetyl-CoA + butanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168638", "l": "Activated IKK phosphorylates I-kappaB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40064", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O => 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672011", "l": "p-AMPK:AMP binds the ULK complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29393", "l": "diphosphate + GMP + H(+) => GTP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46142", "l": "22R-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43128", "l": "guanosine(10) in tRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.214", "l": "\"tRNA (guanine(10)-N(2))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236948", "l": "Antigen processing by cathepsin S in endosoytic vesicle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033888", "l": "chondro-6-sulfatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013147", "l": "RAC1 GDIs block activation of RAC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48927", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM4 (d18:1(4E)) <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854738", "l": "CSF3 dimer:CSFR binds CSFR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800380", "l": "PTPRD binds IL1RAP-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2976726", "l": "NOTCH2 coactivator complex binds HES5 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56095", "l": "bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) <=> biliverdin IXalpha + reduced coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44037", "l": "12,13-epoxy-(9Z)-octadecenoate + H2O => 12,13-dihydroxy-(9Z)-octadecenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16186", "l": "an aldehyde + H2O + NAD(+) => a carboxylate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5689861", "l": "Recruitment of XPA and release of CAK  (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40187", "l": "(2E)-octenoyl-CoA + H2O = (3R)-hydroxyoctanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18415", "l": "a beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->4)-beta-D-glucosyl derivative + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20402", "l": "a beta-lactam + H2O => a substituted beta-amino acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50147", "l": "ethyl (9Z)-hexadecenoate + H2O <=> (9Z)-hexadecenoate + ethanol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30898", "l": "H2O + O2 + propane-1,3-diamine <=> 3-aminopropanal + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44925", "l": "2-oxoadipate + acetyl-CoA + H2O => (R)-dihomocitrate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36993", "l": "alpha-D-ribose 1,5-bisphosphate + uracil => phosphate + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928614", "l": "EFNB:GRB4 binds GIT1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36043", "l": "all-trans-8'-apo-beta-carotenal + O2 = 13-apo-beta-carotenone + 2,6-dimethyldeca-2,4,6,8-tetraenedial"}, {"i": "EC:1.13.11.82", "l": "\"8'-apo-carotenoid 13,14-cleaving dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12506", "l": "3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADH => NAD(+) + thiomorpholine-3-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20206", "l": "methylazoxymethanol + UDP-alpha-D-glucose => cycasin + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57123", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061786", "l": "peptidoglycan stem peptide endopeptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783332", "l": "APP(672-713),APP(672-711) translocate from endosome lumen to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033946", "l": "xyloglucan-specific endo-beta-1,4-glucanase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034783", "l": "pivalate-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36802", "l": "a ribonucleoside 5'-diphosphate + H2O <=> a ribonucleoside 5'-phosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69142", "l": "Recruitment of Dna2 endonuclease (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71445", "l": "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44058", "l": "2-O,3-O-dihexadecanoyl-alpha,alpha-trehalose + CoA => 2-O-hexadecanoyl-alpha,alpha-trehalose + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-443779", "l": "Linkage of L1 with treadmilling F-actin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16386", "l": "4-hydroxybenzoate + 2 H(+) + NADPH + O2 => CO2 + H2O + hydroquinone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47730", "l": "(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + GDP + H(+) => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212356", "l": "Formation of CSL-NICD coactivator complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62909", "l": "nor-toralactone + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + toralactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368081", "l": "Expression of SREBF1 (SREBP1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34295", "l": "2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose = 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29238", "l": "a menaquinone + H(+) + NADH <=> a menaquinol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19158", "l": "D-xylonate => 2-dehydro-3-deoxy-D-arabinonate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0000026", "l": "alpha-1,2-mannosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35981", "l": "diphosphate + fumitremorgin A => dimethylallyl diphosphate + verruculogen"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43691", "l": "N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + pyruvate <=> L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44570", "l": "2-all-trans-hexaprenylphenol + CO2 => 4-hydroxy-3-all-trans-hexaprenylbenzoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56655", "l": "12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+) <=> 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209973", "l": "Tyrosine is diiodinated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55502", "l": "ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta,3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610752", "l": "GLI3R translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38671", "l": "sphinganine 1-phosphate(in) = sphinganine 1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0019215", "l": "intermediate filament binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51101", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41929", "l": "(2E)-octadecenoyl-[ACP] + H(+) + NADPH => NADP(+) + octadecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16047", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP => a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4084912", "l": "Arresten binds integrin alpha1beta1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202203", "l": "Recruitment of PI3K to plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63732", "l": "UDP-alpha-D-glucuronate + zolasartan = UDP + zolarsartan O-beta-D-glucuronoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60691", "l": "(11R)-dihydroartemisinic aldehyde + H2O + NAD(+) <=> (11R)-dihydroartemisinate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46606", "l": "[HPr protein]-L-serine + diphosphate => [HPr protein]-O-phospho-L-serine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31813", "l": "diphosphate + viridiflorene => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0042900", "l": "arabinose transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013004", "l": "RHOA binds effectors at the ER membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18849", "l": "a 2'-unsubstituted isoflavone + O2 + reduced [NADPH--hemoprotein reductase] = a 2'-hydroxyisoflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46502", "l": "CO2 + phosphate + succinate + uridine-5'-aldehyde => 2-oxoglutarate + O2 + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167419", "l": "The receptor:G-protein complex releases GDP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34518", "l": "tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine <=> N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432143", "l": "PECAM-1 binds PP2A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50173", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 => N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14674", "l": "a polar amino acid(out) + ATP + H2O => a polar amino acid(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11783", "l": "3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose <=> 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21257", "l": "3-phosphoshikimate + phosphoenolpyruvate => 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17007", "l": "1-phospho-alpha-D-glucuronate + ADP + H(+) => ATP + D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12397", "l": "dTDP-D-galactose + H2O + 2 NADP(+) => dTDP-D-galacturonate + 3 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18473", "l": "1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP"}, {"i": "EC:2.4.2.17", "l": "\"ATP phosphoribosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30306", "l": "(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003940", "l": "L-iduronidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863718", "l": "AGFG1 binds VAMP7 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32828", "l": "ATP + H2O + methionine(out) => ADP + H(+) + methionine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14396", "l": "N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine <=> 3 H(+) + N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034874", "l": "thioacetamide S-oxide S-oxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66633", "l": "L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29872", "l": "ATP + H2O + thiosulfate(out) => ADP + H(+) + phosphate + thiosulfate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804596", "l": "APAF1:CYCS binds APIP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102396", "l": "9-cis-10'-apo-beta-carotenal cleavage oxygenase activity"}, {"i": "MetaCyc:RXN-13643"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64346", "l": "2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H2O + NADP(+) => 4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41614", "l": "D-ribose 2,5-bisphosphate + H(+) => alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23800", "l": "H2O + L-methionine = 2-oxobutanoate + methanethiol + NH4(+)"}, {"i": "EC:4.4.1.11", "l": "\"Methionine gamma-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12240", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH = 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+)"}, {"i": "EC:2.3.1.165", "l": "\"6-methylsalicylic acid synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62203", "l": "2 [Fe(III)cytochrome c] + ethanol <=> 2 [Fe(II)cytochrome c] + acetaldehyde + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16748", "l": "AH2 + O2 + phylloquinone <=> 2,3-epoxyphylloquinone + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12934", "l": "L-fuculose 1-phosphate => (S)-lactaldehyde + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15852", "l": "2 [Fe(III)cytochrome c] + L-ascorbate <=> 2 [Fe(II)cytochrome c] + 2 H(+) + L-dehydroascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1236970", "l": "Proteasomal clevage of exogenous antigen (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34802", "l": "2,3-didehydroadipoyl-CoA + acetyl-CoA <=> 3-oxo-5,6-didehydrosuberyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4647594", "l": "SAHF formation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443831", "l": "14-3-3-zeta binds Raf1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74723", "l": "Endosome acidification (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39699", "l": "(R)-3-hydroxy-(13Z)-eicosenoyl-CoA = (2E,13Z)-eicosadienoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44868", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + ethanol = 1,2-diacyl-sn-glycero-3-phosphoethanol + choline"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016633", "l": "galactonolactone dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18614", "l": "4-methoxybenzoate + AH2 + O2 => 4-hydroxybenzoate + A + formaldehyde + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68637", "l": "CDC6 protein is synthesized under the control of E2F transcription factors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53526", "l": "1,2-diheptadecanoyl-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53168", "l": "H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35979", "l": "dimethylallyl diphosphate + verruculogen = diphosphate + fumitremorgin A"}, {"i": "EC:2.5.1.107", "l": "\"Verruculogen prenyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803988", "l": "N2O3 enters bacteria (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18653", "l": "barbiturate + H2O = 3-oxo-3-ureidopropanoate"}, {"i": "EC:3.5.2.1", "l": "\"Barbiturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10036", "l": "4-hydroxy-3-methoxy-benzenemethanol + O2 = H2O2 + vanillin"}, {"i": "EC:1.1.3.38", "l": "\"Vanillyl-alcohol oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673797", "l": "NOX1 complex:pp-DVL:RAC1:GTP generates superoxide from oxygen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32128", "l": "2-oxoglutarate + L-proline + O2 => cis-4-hydroxy-L-proline + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983147", "l": "Release of E3 from polyubiquitinated substrate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24014", "l": "(+)-alpha-tocopherol + H(+) + S-adenosyl-L-homocysteine => gamma-tocopherol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16607", "l": "(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+) => dodecanoyl-CoA + H2O + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56007", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66066", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminohexanoate => 2-oxohexanoate + L-kynurenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854209", "l": "TBC1D10A binds JFC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41862", "l": "(2E)-decenoyl-[ACP] + H2O => (3R)-hydroxydecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45690", "l": "N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(out) => N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204871", "l": "Interaction of Tie2 and Grb2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692437", "l": "ANG binds F-actin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853316", "l": "Activated FGFR3 fusions:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682377", "l": "LC3 de-lipidation by ATG4 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17033", "l": "(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) = biphenyl-2,3-diol + H(+) + NADH"}, {"i": "EC:1.3.1.56", "l": "\"Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662617", "l": "MT1G binds cadmium (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12524", "l": "L-pipecolate + NADP(+) = Delta(1)-piperideine-2-carboxylate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102530", "l": "aclacinomycin T methylesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41038", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + hexadecanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-hexadecanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009558", "l": "IL34 dimer binds SDC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-996727", "l": "REST recruits the BHC complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.5.4", "l": "\"Malate dehydrogenase (quinone)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23942", "l": "5-dehydro-D-gluconate + H(+) + NADH => D-gluconate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12774", "l": "2-oxoglutarate + O2 + proclavaminate => CO2 + dihydroclavaminate + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047527", "l": "2,3-dihydroxybenzoate-serine ligase activity"}, {"i": "RHEA:30571", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine = 6 AMP + 6 diphosphate + enterobactin + 4 H(+)"}, {"i": "EC:6.3.2.14", "l": "\"Enterobactin synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905058", "l": "calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium ion concentration"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730851", "l": "Phosphorylation of SLP-76 by p-SYK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005545", "l": "1-phosphatidylinositol binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50994", "l": "thromboxane B2(in) => thromboxane B2(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36384", "l": "carbamoyl adenylate + tobramycin => AMP + H(+) + nebramycin 5'"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45529", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9626817", "l": "PKC phosphorylates NCF1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16541", "l": "9-cis-violaxanthin + O2 = (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0034190", "l": "apolipoprotein receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61634", "l": "5-aminopentanoate + 2 H(+) + NADH => 5-aminopentanal + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53515", "l": "(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O <=> (13R)-S-cysteinylglycinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050640", "l": "isopenicillin-N N-acyltransferase activity"}, {"i": "RHEA:20720", "l": "H2O + isopenicillin N + phenylacetyl-CoA = CoA + H(+) + L-2-aminoadipate + penicillin G"}, {"i": "EC:2.3.1.164", "l": "\"Isopenicillin-N N-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54739", "l": "N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786110", "l": "JAK1 binds IL4R in IL13-bound IL13R type II (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32658", "l": "a carboxylate + eugenol + NADP(+) <=> a coniferyl ester + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-919404", "l": "Phosphorylated STAT5 is released (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371467", "l": "SIRT1 deacetylates HSF1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098638", "l": "laminin binding involved in cell-matrix adhesion"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22540", "l": "5'-dehydroadenosine + H2O + O2 = 9-riburonosyladenine + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848758", "l": "PTK6 phosphorylates AKT1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42281", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.201", "l": "\"Exo-chitinase (reducing end)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36195", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a carboxylate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29316", "l": "alpha-D-galactose 1-phosphate + H2O => D-galactose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029984", "l": "Autocatalytic phosphorylation of FGFR2 ligand-independent  mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.76"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047695", "l": "benzoin aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35810", "l": "2-dehydro-3-deoxy-D-arabinonate <=> 2,5-dioxopentanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37638", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102685", "l": "UDP-glucose:trans-zeatin 7-N-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-4721"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38649", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+) => 1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.71", "l": "\"Sortase B\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28847", "l": "Li(+)(in) + melibiose(in) = Li(+)(out) + melibiose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57199", "l": "H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] <=> glycolate + H(+) + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797553", "l": "Protein 4.1 binds CASK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47917", "l": "ATP + N-hexanoyl-(4R)-hydroxysphinganine => ADP + H(+) + N-hexanoyl-(4R)-hydroxysphinganine-1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39947", "l": "1,3-diacyl-sn-glycerol + H2O = a fatty acid + a monoacylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0005200", "l": "structural constituent of cytoskeleton"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72107", "l": "Formation of the Spliceosomal E complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013143", "l": "RAC1 GEFs activate RAC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.39"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.15", "l": "\"Endo-polygalacturonase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222020", "l": "NUAK1 phosphorylates TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66334", "l": "L-aspartate(in) => L-aspartate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176517", "l": "SULTs transfer (SO4)2- group to PREG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196753", "l": "2xPPCS ligates PPanK with Cys (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814678", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696997", "l": "USP24 deubiquitinates DDB2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10807", "l": "(S)-allantoin <=> (R)-allantoin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66327", "l": "iodide(out) <=> iodide(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21164", "l": "a carboxylic ester + H2O = a carboxylate + an alcohol + H(+)"}, {"i": "EC:3.1.1.1", "l": "\"Carboxylesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33286", "l": "2-hydroxycyclohexan-1-one + NADPH + O2 <=> 6-oxohexanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66249", "l": "CoA + IC-asc-C9-AMP => AMP + H(+) + IC-asc-C9-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34942", "l": "H2O + menaquinone-8 + selenite <=> menaquinol-8 + selenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805126", "l": "AURKB phosphorylates TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034868", "l": "2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6781953", "l": "YOD1 binds VCP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41721", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63878", "l": "(4S)-3(1),4-dihydroxy-L-isoleucine + CO2 + succinate => 2-oxoglutarate + 3(1)-hydroxy-L-isoleucine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45090", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline => a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31079", "l": "3-hydroxyisovaleryl-CoA = 3-methyl-(2E)-butenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59100", "l": "diglucosyl-enterobactin + UDP-alpha-D-glucose = H(+) + triglucosyl-enterobactin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912727", "l": "CBL binds VAV (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44478", "l": "a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine => 1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65144", "l": "2-oxoglutarate + berkeleyone A + O2 = CO2 + H2O + preaustinoid A + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46231", "l": "apo-[peptidyl-carrier protein] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39148", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + CoA => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44220", "l": "15-hydroxypentadecanoate + ATP + CoA = 15-hydroxypentadecanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388830", "l": "PI3K binds ICOS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62558", "l": "4-methylcatechol + CO2 => 3,4-dihydroxyphenylacetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64680", "l": "benzoyl-CoA + ethanol = CoA + ethyl benzoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9659554", "l": "KCNQ4 transports K+ from the cytosol to the extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30481", "l": "2 H(+) + H2O + N-hydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase] => L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56277", "l": "ATP + L-proline => 3'-L-prolyl-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693319", "l": "CTRC hydrolyses PRSS1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39654", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O <=> 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64324", "l": "(11Z)-octadecenoyl-CoA + cholesterol = cholesteryl (11Z)-octadecenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209823", "l": "Tyrosine is hydroxylated to dopa (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023840", "l": "HATs and coactivators are recruited to the CTSD gene (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932351", "l": "KEAP1 facilitates ubiquitination of NFE2L2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607751", "l": "TRAF6 oligomerizes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57121", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16980", "l": "acetoacetate + coenzyme M + NADP(+) <=> 2-oxopropyl-coenzyme M + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13385", "l": "3-oxododecanoate + H(+) = 2-undecanone + CO2"}, {"i": "EC:4.1.1.56", "l": "\"3-oxolaurate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30642", "l": "(R)-glycerate + GDP-alpha-D-mannose <=> (2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192746", "l": "Binding of M1 to vRNP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38678", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57433", "l": "3-methoxycatechol + O2 + reduced [NADH--hemoprotein reductase] => 1,2,3-trihydroxybenzene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32855", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol = a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696146", "l": "AOC2 deaminates TYR (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53004", "l": "2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5368586", "l": "DKK promotes clathrin-dependent internalization of LRP6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182986", "l": "CBL-mediated ubiquitination of CIN85 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000048", "l": "peptidyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419334", "l": "Melatonin receptors can bind melatonin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17018", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA => (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17735", "l": "CO2 + pyruvate => acetylenedicarboxylate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12369", "l": "2-dehydro-D-gluconate + A => 2,5-didehydro-D-gluconate + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64761", "l": "H2O + S-ethyl-L-cysteine => ethanethiol + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2002466", "l": "Formation of allysine by LOX (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45497", "l": "[allophycocyanin alpha-subunit]-Cys(84)-phycocyanobilin => (2R,3E)-phycocyanobilin + apo-[allophycocyanin alpha-subunit]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18705", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202168", "l": "Phosphorylation of ZAP-70 by Lck (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38931", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1964496", "l": "STING binds TRIM32 or TRIM56  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60053", "l": "a 3beta-hydroxy-4,4-dimethylsteroid + H(+) + NADH + O2 => a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13299", "l": "CO2 + CoA + eicosanoyl-CoA + H2O + 2 NAD(+) => 3 H(+) + malonyl-CoA + 2 NADH + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35784", "l": "neamine + UDP-alpha-D-kanosamine => H(+) + kanamycin B + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198314", "l": "DAG stimulates protein kinase C-delta (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19296", "l": "a monoacylglycerol + ATP <=> ADP + H(+) + monoacyl-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801101", "l": "RABGGTA binds RABGGTB (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804955", "l": "ATM phosphorylates MDM2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48659", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57471", "l": "(E)-ferulate + UDP-alpha-D-glucose <=> 1-O-[(E)-feruloyl]-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48459", "l": "1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O <=> 2-octanoyl-3-O-beta-D-galactosyl-sn-glycerol + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102907", "l": "sesquisabinene synthase activity"}, {"i": "MetaCyc:RXN-8622"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42971", "l": "cytidine(56) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34790", "l": "a 3beta-hydroxysteroid + NADP(+) <=> a 3-oxosteroid + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24323", "l": "an L-polyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> an L-N-hydroxypolyhomomethionine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49266", "l": "(E)-caffeate + H(+) + shikimate => 5-O-[(E)-caffeoyl]-shikimate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375151", "l": "Interaction of NCAM1 with collagens (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190256", "l": "FGFR1c binds to FGF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33517", "l": "2 H2O + 2 indole-5,6-quinone => 2 5,6-dihydroxyindole + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41171", "l": "1-acyl-2-hexadecenoyl-sn-glycero-3-phosphate + H2O = 2-hexadecenoyl-sn-glycero-3-phosphate + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961671", "l": "E2F1 binds the ORC1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619127", "l": "CAMK4 binds KPNA2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034711", "l": "inhibin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66684", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[GAPDH] = L-cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36830", "l": "dioscin + 3 H2O <=> D-glucose + diosgenin + 2 L-rhamnopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.16"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11447", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O <=> 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44635", "l": "(3,5-dihydroxyphenyl)acetyl-CoA + O2 <=> 2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696564", "l": "USP25 deubiquitinates DDX58 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668023", "l": "TPST1,2 transfer SO4(2-) from PAPS to FVIII (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18548", "l": "2-dehydro-3-deoxy-L-arabinonate <=> glycolaldehyde + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811454", "l": "MAPKs phosphorylate PP2A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174786", "l": "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198270", "l": "PDPK1 phosphorylates AKT at T308 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.100", "l": "\"Sedolisin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13609", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)"}, {"i": "EC:2.7.1.150", "l": "\"1-phosphatidylinositol-3-phosphate 5-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52800", "l": "acetoacetyl-CoA + ATP + L-isoleucine = AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid"}, {"i": "EC:6.3.2.50", "l": "\"Tenuazonic acid synthetase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22828", "l": "1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)"}, {"i": "EC:3.6.1.31", "l": "\"Phosphoribosyl-ATP diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11702", "l": "H2O + NADP(+) + testosterone acetate => H(+) + NADPH + O2 + progesterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.3", "l": "\"Type I site-specific deoxyribonuclease\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2691211", "l": "NOTCH1 HD domain mutants bind DLL4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58578", "l": "H(+) + NADPH + precondylocarpine acetate => dihydroprecondylocarpine acetate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70427", "l": "PGM:Mg2+ isomerise G1P to G6P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2545253", "l": "Deacetylation of cohesin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56245", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => 2-hexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl hexadecanoate + apo--[retinol-binding protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165047", "l": "Translocation of nuclear RNA transport complex to cytoplasm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18595", "l": "hexadecanal + phosphoethanolamine => sphinganine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22166", "l": "globoside Forssman (d18:1(4E)) + H(+) + UDP => globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809764", "l": "SBF1 binds MTMR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34787", "l": "a 3beta-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090492", "l": "N,N-Dihydroxy-L-tryptophan decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874718", "l": "TTPA binds alpha-TOH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625913", "l": "Hypochlorous acid (HOCL) reacts with Lys-monochloramine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655142", "l": "RCHY1 binds POLH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70420", "l": "HK1,2,3,GCK phosphorylate Glc to form G6P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32074", "l": "geranylgeranyl diphosphate <=> (13E)-labda-7,13-dien-15-yl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45057", "l": "deoxynogalonate + O2 => H(+) + H2O + nogalonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956568", "l": "RUNX1 binds the core TAL1 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52057", "l": "12-hexadecanoyloxy-octadecanoate + H2O => 12-hydroxyoctadecanoate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781922", "l": "USP13 binds UFD1L:SKP2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803892", "l": "SFN dimer binds BAX (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851979", "l": "BTNL9 binds immune cell surfaces (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21663", "l": "benzaldehyde + H2O + NADP(+) <=> benzoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1362416", "l": "Frataxin binds iron (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112604", "l": "Phosphorylated STATs are released (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30477", "l": "D-glucuronate + H(+) + oroxylin A => H2O + oroxylin A 7-O-beta-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12356", "l": "D-mannose 6-phosphate = D-fructose 6-phosphate"}, {"i": "EC:5.3.1.8", "l": "\"Mannose-6-phosphate isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032030", "l": "myosin I light chain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.6", "l": "\"Coagulation factor Xa\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44516", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O = (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "80.155824608458104", "identifiers": [{"i": "GO:0070492", "l": "oligosaccharide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191402", "l": "Reduction of presqualene diphosphate to form squalene (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038186", "l": "lithocholic acid receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940959", "l": "Neurolysin degrades neurotensin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901359", "l": "tungstate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28407", "l": "H2O + XTP => H(+) + phosphate + XDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21407", "l": "chloride + O2 <=> chlorite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607734", "l": "PKC-delta translocates to plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015240", "l": "amiloride transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211968", "l": "CYP2W1 oxidises INDOL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1067640", "l": "IL6 binds IL6R-2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047285", "l": "flavonol-3-O-glycoside xylosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40102", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800798", "l": "The PIDDosome binds CASP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31443", "l": "ATP + D-sedoheptulose 7-phosphate = ADP + H(+) + sedoheptulose 1,7-bisphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64911", "l": "CTP + 2 H2O <=> CMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354124", "l": "Phosphorylation of pPTK2 by SRC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18134", "l": "ATP + H(+) + sulfate => adenosine 5'-phosphosulfate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62042", "l": "N-octanoylsphing-4-enine + phosphate => H2O + N-(octanoyl)-sphing-4-enine-1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59936", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16793", "l": "H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = CO2 + D-pantetheine 4'-phosphate"}, {"i": "EC:4.1.1.36", "l": "\"Phosphopantothenoylcysteine decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0039660", "l": "structural constituent of virion"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5159250", "l": "ATF7IP binds SETDB1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "66.945115279808661", "identifiers": [{"i": "GO:0016877", "l": "ligase activity, forming carbon-sulfur bonds"}, {"i": "EC:6.2.-.-", "l": "\"Forming carbon-sulfur bonds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52340", "l": "a long-chain fatty acyl-AMP + holo-[mycocerosate synthase] = AMP + H(+) + long-chain fatty acyl-[mycocerosate synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390663", "l": "ADRA2A,B,C bind ADR,NAd (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902051", "l": "(25S)-Delta(4)-dafachronate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23386", "l": "beta-D-glucosyl-(1->4)-D-mannopyranose => D-cellobiose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57342", "l": "3-hydroxy-4-methyl-L-kynurenine + H(+) + S-adenosyl-L-homocysteine => 3-hydroxy-L-kynurenine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35657", "l": "3',3'-c-di-AMP + 2 diphosphate => 2 ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944233", "l": "Association of procollagen type XIX (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047717", "l": "imidazoleacetate 4-monooxygenase activity"}, {"i": "MetaCyc:IMIDAZOLEACETATE-4-MONOOXYGENASE-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990439", "l": "MAP kinase serine/threonine phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14391", "l": "an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63301", "l": "N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49352", "l": "2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2'-hydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688834", "l": "ATXN3 binds VCP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30298", "l": "GTP + pyruvate <=> GDP + H(+) + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390929", "l": "HTR1 and 5A receptors can bind serotonin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45069", "l": "(R)-carnitine + an acyl-CoA => CoA + O-acyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12699", "l": "ADP + dGDP => ATP + dGMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668395", "l": "CHMP7 binds CC2D1B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46003", "l": "adenosine + H(+) + tuberculosinyl diphosphate <=> 1-tuberculosinyladenosine + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672011", "l": "p-AMPK:AMP binds the ULK complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675206", "l": "PEA15 binds MAPK monomers and dimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23954", "l": "2-phenylethylamine + acetate => H2O + N-(2-phenylethyl)acetamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35638", "l": "an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + UDP-alpha-D-glucose <=> an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25255", "l": "ADP + H(+) + N-acetyl-D-mannosamine 6-phosphate => ATP + N-acetyl-D-mannosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009371", "l": "Binding of AP1 transcriptional activator complexes to CCND1 promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17088", "l": "4-pyridoxate + A <=> 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1471322", "l": "Beta-defensins are secreted (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34946", "l": "hydroquinone O-beta-D-glucopyranoside(out) + phosphoenolpyruvate(in) <=> arbutin 6-phosphate(in) + pyruvate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38711", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecylglycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008909", "l": "isochorismate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.69"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24093", "l": "2 H(+) + O2 + 2 sulochrin => 2 (2S)-bisdechlorogeodin + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29182", "l": "a menaquinol + 2 O2 <=> a menaquinone + 2 H(+) + 2 superoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30214", "l": "2 [Fe(III)cytochrome c] + H2O + nitrous oxide <=> 2 [Fe(II)cytochrome c] + 2 H(+) + 2 nitric oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419644", "l": "Transphosphorylation of pLIMK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839094", "l": "Activated FGFR1 mutants and fusions bind PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45275", "l": "12-phosphooxy-(9Z)-octadecenoate + H2O <=> 12-hydroxy-(9Z)-octadecenoate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-561072", "l": "OCT3 mediates renal uptake of organic cations (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23857", "l": "H(+) + Hg + NADP(+) => Hg(2+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47438", "l": "(3S)-hydroxy-(7Z-hexadecenoyl)-CoA => (2E,7Z)-hexadecadienoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25014", "l": "H(+) + N,N-dihydroxy-L-tryptophan => (E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627104", "l": "XIAP binds CASP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20295", "l": "3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH => 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75172", "l": "Formation of RAD50:MRE11 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420121", "l": "SFKs phosphorylate PLCG1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42358", "l": "3-oxo-(11Z)-hexadecenoyl-CoA + CO2 + CoA => (9Z)-tetradecenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190662", "l": "Connexin oligomerization in Trans-Golgi Network (TGN) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12057", "l": "D-erythrose 4-phosphate + H2O + NAD(+) => 4-phospho-D-erythronate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18584", "l": "ethanolamine + H2O + O2 <=> glycolaldehyde + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74715", "l": "Autophosphorylation of insulin receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172123", "l": "Interaction of SIGLEC14/15/16 and DAP12 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852317", "l": "PLK1 phosphorylates GTSE1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14239", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sarpagine => 10-deoxysarpagine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417908", "l": "P2RY1 binds ADP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-593685", "l": "Netrin-4 binds DCC/UNC5A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24143", "l": "guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9678854", "l": "S1PR1 binds S1PR1 agonists (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981832", "l": "NMUR2 binds neuromedin-S (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.-.-", "l": "\"Intramolecular oxidoreductases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626816", "l": "PIN1 binds p-S345-NCF1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710254", "l": "GSDME oligomerizes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799246", "l": "CHEK1 phosphorylates TP53 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865454", "l": "CBFB binds RUNX3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34441", "l": "3-oxo-5,6-didehydrosuberyl-CoA + CoA => 2,3-didehydroadipyl-CoA + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13944", "l": "ATP + D-glyceraldehyde <=> ADP + D-glyceraldehyde 3-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416725", "l": "SEMA6D binds to PLXNA1:TREM2:DAP12 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11950", "l": "4-hydroxybenzoate + CoA + H(+) => 4-hydroxybenzoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65796", "l": "fenuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20745", "l": "NADP(+) + prostaglandin D2 => 15-oxoprostaglandin D2 + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683755", "l": "Spike protein gets N-glycosylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375140", "l": "CDO binds promyogenic cadherins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198270", "l": "PDPK1 phosphorylates AKT at T308 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50831", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 <=> (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E)-docosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614544", "l": "Sulfite is oxidized to sulfate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-917693", "l": "ESCRT Disassembly (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28055", "l": "2-oxobutanoate + CoA => formate + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047361", "l": "phosphomannan mannosephosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36438", "l": "a 1,2-diacyl-sn-glycero-3-phosphate(in) <=> a 1,2-diacyl-sn-glycero-3-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507868", "l": "Aquaporins passively transport water into cells (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57219", "l": "dGTP + glyoxal <=> N(2)-(1-hydroxy-2-oxoethyl)-dGTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3780997", "l": "PPP1R3C binds to glycogen:GYG2:GYS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62915", "l": "H(+) + NADH + O2 + toralactone <=> 1-(3,4,5-trihydroxy-7-methoxynaphthalen-2-yl)propan-2-one + CO2 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187895", "l": "Engulfed CpG DNA binds to endosomal C-ter TLR9 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41919", "l": "H(+) + hexadecanoyl-[ACP] + malonyl-[ACP] <=> 3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27333", "l": "6-hydroxynicotinate + 2 H(+) + NADH + O2 = 2,5-dihydroxypyridine + CO2 + H2O + NAD(+)"}, {"i": "EC:1.14.13.114", "l": "\"6-hydroxynicotinate 3-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483174", "l": "PE is methylated to PC by PEMT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29712", "l": "cadaverine(in) + H(+)(in) => cadaverine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17521", "l": "ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate"}, {"i": "EC:6.3.5.7", "l": "\"Glutaminyl-tRNA synthase (glutamine-hydrolyzing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56213", "l": "O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016995", "l": "cholesterol oxidase activity"}, {"i": "MetaCyc:CHOLESTEROL-OXIDASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9679044", "l": "FKBP1A binds sirolimus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112396", "l": "Separation of elongating transcript from template (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51519", "l": "(R)-reticuline + S-adenosyl-L-methionine <=> (R)-tembetarine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72130", "l": "Formation of an intermediate Spliceosomal C (Bact) complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44957", "l": "(2E)-hexenoyl-CoA + H(+) + NADPH => hexanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371435", "l": "Constitutive phosphorylation by GSK3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936851", "l": "AHRR binds ARNT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39024", "l": "an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49753", "l": "2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate => CO2 + 2 H2O + NAD(+) + proviolacein"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48902", "l": "3,8-divinyl chlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => chlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216045", "l": "Collagen type I binds integrin alpha11beta1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426032", "l": "DAG is metabolized by DAGL to 2-AG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018747", "l": "RHOQ GEFs activate RHOQ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052818", "l": "heteroglycan 3-alpha-mannosyltransferase activity"}, {"i": "MetaCyc:RXN-7992"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17499", "l": "ononin + UDP => formononetin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8858500", "l": "CLEC10A binds Tn-MUC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59498", "l": "(20S)-ginsenoside C-K + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16623", "l": "H2O2 + sanguinarine => dihydrosanguinarine + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55974", "l": "CoA + ethyl acetate => acetyl-CoA + ethanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665767", "l": "Activated FMNL3 binds G-actin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6786650", "l": "DDHD1,2 hydrolyse PA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675417", "l": "PEBP1 binds activated RAF1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109862", "l": "MAP2K2 phosphorylates MAPK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11892", "l": "6-O-methylnorlaudanosoline + S-adenosyl-L-methionine = H(+) + nororientaline + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.121", "l": "\"6-O-methylnorlaudanosoline 5'-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29642", "l": "alpha-maltohexaose + H2O <=> alpha-D-glucose + alpha-maltopentaose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5653957", "l": "Rag dimer formation (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19460", "l": "2-nitrophenol + 2 H(+) + 2 NADPH + O2 <=> catechol + H2O + 2 NADP(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034546", "l": "2,4-dichloroaniline reductive dehalogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35765", "l": "aflatoxin B2 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase] => 8-O-methyldihydrosterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39156", "l": "(3R)-hydroxyoctadecanoyl-CoA => (2E)-octadecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433506", "l": "Phosphorylation of APS (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11111", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate <=> n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350388", "l": "ROK binds to activated RHO1:GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2172678", "l": "PHF8 demethylates histone H4K20me1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4332236", "l": "CBL neddylates TGFBR2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77068", "l": "Activation of GT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004771", "l": "sterol esterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163310", "l": "TFAM binds to mitochondrial promoters (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22611", "l": "H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate <=> (2S,6S)-2,6-diaminoheptanedioate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48268", "l": "4',4'-dihydroxyechinenone = canthaxanthin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52074", "l": "(9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H(+) => 12-(9Z-hexadecenoyloxy)-octadecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.30", "l": "\"Phycobiliprotein beta-cysteine-155 phycobilin lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45836", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55622", "l": "a carotenoid beta-end derivative => a carotenoid psi-end group"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70971", "l": "citrate <=> isocitrate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211482", "l": "HNF1A-dependent synthesis of FOXA3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009485", "l": "IL34:CSF1 binds CSF1R (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19378", "l": "NADP(+) + reduced riboflavin => 2 H(+) + NADPH + riboflavin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665121", "l": "ERBB2 KD mutants bind TKIs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47552", "l": "glycodeoxycholate + H2O = deoxycholate + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660015", "l": "Defective RPIA does not isomerize R5P to RU5P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28796", "l": "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46822", "l": "4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50783", "l": "NADP(+) + octanal <=> (2E)-octenal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396083", "l": "Laminins bind galactosyl sulfatide and related sulfated glycolipids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48247", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 <=> CMP + ganglioside GM1b + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27803", "l": "(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate => all-trans-decaprenyl diphosphate + 7 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65323", "l": "2-oxoglutarate + chrodrimanin E + O2 <=> chrodrimanin A + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662596", "l": "MT1F binds cadmium (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39894", "l": "devancoaminyl-vancomycin + dTDP-beta-L-vancosamine <=> dTDP + H(+) + vancomycin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23245", "l": "propane-1,3-diamine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + norspermidine + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374919", "l": "Noradrenaline clearance from the synaptic cleft (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64247", "l": "a fatty acyl-CoA + glycine <=> an N-(fatty acyl)-glycine + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10494", "l": "choline + phosphate => H2O + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24416", "l": "2,4'-dihydroxyacetophenone + O2 = 4-hydroxybenzoate + formate + 2 H(+)"}, {"i": "EC:1.13.11.41", "l": "\"2,4'-dihydroxyacetophenone dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675431", "l": "PP2A dephosphorylates RAF1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37564", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60635", "l": "all-trans-4-oxoretinol + NAD(+) <=> all-trans-4-oxoretinal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52754", "l": "beta-D-glucose + D-glucose => H2O + isomaltose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853405", "l": "TPX2 binds AURKA at centrosomes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141439", "l": "Release of activated MAD2 from kinetochores (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708457", "l": "HM13 cleaves HMOX1 dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27334", "l": "6-hydroxynicotinate + 2 H(+) + NADH + O2 => 2,5-dihydroxypyridine + CO2 + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "78.047734625335977", "identifiers": [{"i": "GO:0022829", "l": "wide pore channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54515", "l": "peregrinol diphosphate <=> (13R)-9,13-epoxylabd-14-ene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58685", "l": "FAD + 2 H(+) + NADPH + O2 => FADH2-C4alpha-hydroperoxide + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848726", "l": "PTK6 phosphorylates BCAR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19745", "l": "3,3',5-triiodo-L-thyronine + A + H(+) + iodide = AH2 + L-thyroxine"}, {"i": "EC:1.21.99.4", "l": "\"Thyroxine 5'-deiodinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40581", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+) => 1-O-(1Z)-hexadecenyl-2 (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "72.787515020653174", "identifiers": [{"i": "GO:0016708", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139898", "l": "Caspase-8 activates BID by cleavage (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18402", "l": "(E)-4-hydroxyphenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] => (S)-4-hydroxymandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11488", "l": "all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA"}, {"i": "EC:2.3.1.76", "l": "\"Retinol O-fatty-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855131", "l": "VLDLR:PCSK9 binds Clathrin-coated vesicles (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016401", "l": "palmitoyl-CoA oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109639", "l": "Formation of the closed pre-initiation complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404135", "l": "RBP4 binds atROL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28991", "l": "N-acetylneuraminate(in) = N-acetylneuraminate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24938", "l": "H2O + imidazol-4-one <=> N-formimidoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16375", "l": "(R)-4'-phosphopantothenate + ADP + H(+) => (R)-pantothenate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70479", "l": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662608", "l": "MT2A binds cadmium (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28059", "l": "L-lyxose => L-xylulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21148", "l": "indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose = 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP"}, {"i": "EC:2.4.1.156", "l": "\"Indolylacetyl-myo-inositol galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62598", "l": "(6E)-8-oxogeranial + H(+) + NADH => (S)-8-oxocitronellyl enol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48272", "l": "2-methylhexanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 2-methylhexenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2426569", "l": "Interaction of DAP12 and IREM2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372843", "l": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13452", "l": "2-hydroxyglutarate + NAD(+) <=> 2-oxoglutarate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684096", "l": "CDK2 phosphorylates RBBP8 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202969", "l": "Caspase mediated cleavage of beta-catenin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44228", "l": "9-decenoate + ATP + CoA = 9-decenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74986", "l": "Elongation of pre-rRNA transcript (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65153", "l": "(2S)-naringenin + UDP-alpha-D-glucose => (2S)-naringenin 7-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175250", "l": "Suicidal integration leading to smaller circles of viral DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58536", "l": "glycine + hexadecanoyl-CoA = CoA + H(+) + N-hexadecanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41536", "l": "2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine = 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.303", "l": "\"2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031693", "l": "alpha-1D adrenergic receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18945", "l": "2-oxoglutarate + L-prolyl-[collagen] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[collagen]"}, {"i": "EC:1.14.11.2", "l": "\"Procollagen-proline 4-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000319", "l": "sulfite transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34313", "l": "2-hydroxy-1,4-benzoquinone + H2O + NAD(+) + nitrite => 4-nitrocatechol + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391936", "l": "EP1 receptor can bind PGE2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731924", "l": "EDNRA binds EDNs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173723", "l": "C8 binds C5b:C6:C7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68849", "l": "Mcm2-7 associates with the Cdt1:CDC6:ORC:origin complex, forming the pre-replicative complex (preRC) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33900", "l": "FAD + H(+) + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose => FADH2 + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63554", "l": "angiotensin-(1-5) + L-histidyl-L-proline => angiotensin-(1-7) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102879", "l": "(+)-thujopsene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48536", "l": "1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O = 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11119", "l": "acetyl-CoA + an alkane-alpha,omega-diamine <=> an N-acetylalkane-alpha,omega-diamine + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58150", "l": "acetate + ethanol + H(+) => ethyl acetate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21174", "l": "5-dehydro-D-gluconate + H(+) + NADH => L-idonate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932327", "l": "NFE2L2 binds KEAP1:CUL3:RBX1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790454", "l": "SUMOylation of XPC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37937", "l": "8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O => (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63608", "l": "apelin-17 + H2O = apelin-16 + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66647", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + trichobrasilenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41738", "l": "adenosine 3',5'-bisphosphate + beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) => 3'-phosphoadenylyl sulfate + a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18986", "l": "chorismate => isochorismate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4093329", "l": "EFNBs bind SDCBP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382055", "l": "Grb7 binds to the active PDGF receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57957", "l": "dimethyl sulfoxide + H(+) + NADH + O2 => dimethyl sulfone + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452750", "l": "Expression of FOXD3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782820", "l": "USP17 deubiquitinates SUDS3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36198", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a carboxylate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163090", "l": "Elongation Of The Telomeric Chromosome End (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.76", "l": "\"Deoxyadenosine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58358", "l": "CO2 + formaldehyde + L-arginyl-[protein] + succinate => 2-oxoglutarate + N(omega)-methyl-L-arginyl-[protein] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654625", "l": "Activated FGFR3 binds SHC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18539", "l": "2 H(+) + NADH + salicylate => H2O + NAD(+) + salicylaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54459", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3814820", "l": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56938", "l": "testosterone => 17beta-hydroxy-androst-5-en-3-one"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120092", "l": "crotonyl-CoA hydratase activity"}, {"i": "RHEA:45584", "l": "3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692768", "l": "MAPKAPK5 phosphorylates KALRN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797554", "l": "ABP1 binds SHANK proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47484", "l": "deoxycholate + NAD(+) = 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451311", "l": "Activation of Ca-permeable Kainate receptors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49294", "l": "6-phospho-beta-D-glucosyl-(1->4)-D-glucose(in) + L-histidyl-[protein] => D-cellobiose(out) + N(pros)-phospho-L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29355", "l": "dUMP + H2O = 2'-deoxyuridine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55436", "l": "ferruginol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + salviol"}, {"i": "EC:1.14.14.62", "l": "\"Salviol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693319", "l": "CTRC hydrolyses PRSS1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32907", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + 2 H2O = 2 a carboxylate + 2 H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18955", "l": "H(+) + NADPH + sepiapterin => L-erythro-7,8-dihydrobiopterin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35967", "l": "fumitremorgin C + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 12alpha,13alpha-dihydroxyfumitremorgin C + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.119", "l": "\"Fumitremorgin C monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47691", "l": "cis-4-hydroxy-L-proline + NADP(+) <=> Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451310", "l": "Activation of Edited Kainate receptors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13290", "l": "dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432067", "l": "Aquaporin-4 passively transports water out of cell (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.59"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18635", "l": "2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate => 2 ATP + H2O + hydrogencarbonate + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1974676", "l": "Beta defensin 103 activates TLR1:TLR2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866304", "l": "pre-VLDL binds lipids to form VLDL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38827", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19940", "l": "glycine + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + sarcosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047021", "l": "15-hydroxyprostaglandin dehydrogenase (NADP+) activity"}, {"i": "KEGG.REACTION:R04552"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928631", "l": "GIT1 binds bPIX (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19265", "l": "carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH"}, {"i": "EC:1.1.1.108", "l": "\"Carnitine 3-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42510", "l": "5-acetamidopentanoate + CO2 + H(+) + NADH => 6-acetamido-2-oxohexanoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59641", "l": "D-xylotetraose + O2 => D-xylotetraono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59084", "l": "2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose = 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5220959", "l": "TDG excises 5-formylcytosine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980112", "l": "Cleavage of DNER:NOTCH1 complex releases NICD1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48595", "l": "a quinone + formate + H(+) <=> a quinol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11684", "l": "methylarsonous acid + S-adenosyl-L-methionine = dimethylarsinate + 2 H(+) + S-adenosyl-L-homocysteine"}, {"i": "RHEA:15293", "l": "arsenite + S-adenosyl-L-methionine = H(+) + methylarsonate + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.137", "l": "\"Arsenite methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627104", "l": "XIAP binds CASP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684309", "l": "3CLp cleaves nsp6-11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20138", "l": "10-deacetylbaccatin III + acetyl-CoA => baccatin III + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11190", "l": "L-aspartate + NH4(+) => 3-cyano-L-alanine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2855047", "l": "Hydrolysis of internal thioester in C4b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28554", "l": "D-mannose 6-phosphate + H2O = D-mannose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32669", "l": "H(+) + hydrogen sulfide + methyl-coenzyme M => coenzyme M + methanethiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.62", "l": "\"Magnolysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2168038", "l": "Collagen type XV restin release (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785478", "l": "Processed tRNA binds XPOT and RAN:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40695", "l": "1-hexadecanoylglycerone 3-phosphate + heptadecan-1-ol = 1-O-heptadecylglycerone 3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647631", "l": "GSDMD (1-275) binds PIPs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-196964", "l": "RFK:Mg2+ phosphorylates RIB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854408", "l": "APOBR dimer binds VLDLs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16044", "l": "[(1->3)-beta-D-glucosyl](n) + phosphate <=> [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25227", "l": "H(+) + L-arabinose + NADH => L-arabinitol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174124", "l": "Dephosphorylation of phospho-Cdh1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45358", "l": "(11Z)-eicosenoate + sphing-4-enine => H2O + N-(11Z-eicosenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004522", "l": "ribonuclease A activity"}, {"i": "EC:4.6.1.18", "l": "\"Pancreatic ribonuclease\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50695", "l": "ADP-alpha-D-glucose + alpha-D-glucose 1-phosphate <=> ADP + alpha-maltose 1-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70655", "l": "L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849102", "l": "SRMS phosphorylates PTK6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24409", "l": "adenosine + H(+) + H2O => inosine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357828", "l": "RIPK1 is cleaved by CASP8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212642", "l": "L-Glutamine transport into neurons (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14081", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = D-glyceraldehyde 3-phosphate + indole"}, {"i": "EC:4.1.2.8", "l": "\"Indole-3-glycerol-phosphate lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8862280", "l": "FCHo proteins bind nascent clathrin-coated pit (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034700", "l": "allulose 6-phosphate 3-epimerase activity"}, {"i": "RHEA:28426", "l": "D-allulose 6-phosphate = keto-D-fructose 6-phosphate"}, {"i": "MetaCyc:RXN0-304"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373747", "l": "Phosphorylation of nephrin by FYN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59880", "l": "4-hydroxyphenylacetate + FMNH2 + O2 = 3,4-dihydroxyphenylacetate + FMN + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26209", "l": "L-allo-threonine = acetaldehyde + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14206", "l": "carnosine + S-adenosyl-L-methionine => anserine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004060", "l": "arylamine N-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59446", "l": "1,1'-dihydroxy-3,4-didehydro-1,2-dihydrolycopene + AH2 => 1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22572", "l": "A + H2O + N-methyl-L-glutamate = AH2 + formaldehyde + L-glutamate"}, {"i": "EC:1.5.99.5", "l": "\"Methylglutamate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66186", "l": "3',5'-cyclic AMP(out) + ADP + H(+) + phosphate => 3',5'-cyclic AMP(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193964", "l": "CYP21A2 21-hydroxylates PROG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65690", "l": "a diacylglycerol + an N-(38-(9Z,12Z-octadecadienoyloxy)-octatriacontenoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(38-hydroxyoctatriacontenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59421", "l": "H2O + methylamine + O2 => formaldehyde + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102073", "l": "OPC8-trans-2-enoyl-CoA hydratase activity"}, {"i": "MetaCyc:RXN-10697"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018814", "l": "RHOT1 hydrolyzes GTP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35821", "l": "7,8-dihydromethanopterin + H(+) + NADPH => 5,6,7,8-tetrahydromethanopterin + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28644", "l": "(2E,6E)-farnesyl diphosphate => alpha-zingiberene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023549", "l": "PTPN1 gene expression is inhibited by MECP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938815", "l": "RNF152 polyubiquitinates RRAGA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668904", "l": "Formation of the CTF18 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42188", "l": "3beta-hydroxy-5alpha-androstan-17-one + NAD(+) = 5alpha-androstan-3,17-dione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.99.1.2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015566", "l": "acriflavine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65650", "l": "a diacylglycerol + N-(28-(9Z,12Z-octadecadienoyloxy)-octacosanoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(28-hydroxyoctacosanoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55604", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-acyl-sphingoid base = a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-acylsphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20661", "l": "D-alanyl-D-alanine + H2O = 2 D-alanine"}, {"i": "EC:3.4.13.22", "l": "\"D-Ala-D-Ala dipeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49080", "l": "dibenzothiophene 5-oxide + FMNH2 + O2 = dibenzothiophene 5,5-dioxide + FMN + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35159", "l": "(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O = (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54605", "l": "2-oxoglutarate + decanoyl-CoA + O2 => 2-hydroxydecanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42932", "l": "cytidine(32) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "RHEA:42936", "l": "S-adenosyl-L-methionine + uridine(32) in tRNA = 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.200", "l": "\"tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9688459", "l": "RIPK3 binds HSP90:CDC37 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35467", "l": "(6S)-5,6,7,8-tetrahydrofolate + S,S-dimethyl-beta-propiothetin = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-(methylsulfanyl)propanoate + H(+)"}, {"i": "EC:2.1.1.269", "l": "\"Dimethylsulfoniopropionate demethylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64774", "l": "2-aminoprop-2-enoate + 2-methyl-3-sulfanylbutan-1-ol => S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.22.-.-", "l": "\"Acting on halogen in donors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42626", "l": "(Z)-3-aminoacrylate + CO2 + NH4(+) => (Z)-3-ureidoacrylate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416690", "l": "SEMA4A binds to PLXND1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008112", "l": "nicotinamide N-methyltransferase activity"}, {"i": "REACT:R-HSA-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62740", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) = 1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23215", "l": "H2O + N-acetyl-beta-alanine <=> acetate + beta-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58432", "l": "(E)-4-oxonon-2-en-1-ol + NADP(+) = (E)-4-oxonon-2-enal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32868", "l": "myo-inositol(out) => myo-inositol(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39588", "l": "3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20009", "l": "2-hydroxy-2-methylpropanenitrile + UDP-alpha-D-glucose = H(+) + linamarin + UDP"}, {"i": "EC:2.4.1.63", "l": "\"Linamarin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48316", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b = a ganglioside GD1alpha + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428273", "l": "SPHK1 phosphorylates SPG to S1P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901036", "l": "MAN1B1 hydrolyses a second 1,2-linked mannose (a branch) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31162", "l": "(3S)-hydroxyhexadecanoyl-CoA + NAD(+) <=> 3-oxohexadecanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428534", "l": "Recruitment of Profilin by Ena/VASP proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23040", "l": "2-oxobutanoate + acetyl-CoA + H2O = (R)-2-ethylmalate + CoA + H(+)"}, {"i": "EC:2.3.3.6", "l": "\"2-ethylmalate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20801", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14262", "l": "(E)-sinapoyl-CoA + D-glucono-1,5-lactone => 6-O-[(E)-sinapoyl]-D-glucono-1,5-lactone + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008261", "l": "allatostatin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25760", "l": "ent-copalyl diphosphate => diphosphate + ent-isokaurene"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033994", "l": "glucuronan lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10898", "l": "2 H(+) + limonoate => 2 H2O + limonin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102250", "l": "linear malto-oligosaccharide phosphorylase activity"}, {"i": "RHEA:41732", "l": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate"}, {"i": "MetaCyc:RXN-12392"}, {"i": "EC:2.4.1.1", "l": "\"Glycogen phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21654", "l": "catechol + chloride + CO2 + NAD(+) => 2-chlorobenzoate + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047753", "l": "choline-sulfatase activity"}, {"i": "KEGG.REACTION:R01028"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46288", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29195", "l": "(S)-dihydroorotate + a menaquinone = a menaquinol + orotate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42534", "l": "pseudouridine(55) in tRNA => uridine(55) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66537", "l": "A + cholest-4,6-dien-3-one + H2O => 25-hydroxycholest-4,6-dien-3-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14200", "l": "ATP + L-aspartate + NH4(+) <=> ADP + H(+) + L-asparagine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202960", "l": "Caspase mediated cleavage of C-IAP1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15270", "l": "L-xylo-hex-3-ulonolactone => H(+) + L-ascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388596", "l": "Melanocortin receptors bind melanocortins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2514865", "l": "cGMP dissociates from CNG channels (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5251942", "l": "Hikeshi binds HSP70s:ATP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50276", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18978", "l": "a quinone + sn-glycerol 3-phosphate => a quinol + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48152", "l": "ganglioside GD1b(d18:1(4E)/18:0) + H2O = ganglioside GM1 (d18:1(4E)/18:0) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54103", "l": "N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942302", "l": "MMP13 cleaves OPTC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37210", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602454", "l": "proMMP9 binds TIMP1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63145", "l": "H2O + N-(15Z-tetracosenoyl)-ethanolamine => (15Z)-tetracosenoate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14538", "l": "1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H(+) + H2O => 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622310", "l": "Activated NOD1 oligomerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34408", "l": "3 ATP => 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865693", "l": "BRWD1 gene expression is repressed by STAT5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111237", "l": "Formation of ADAR1 homodimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51032", "l": "7-chloroindole-3-pyruvate imine dimer = dichlorochromopyrrolate + H(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24296", "l": "(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate"}, {"i": "EC:3.5.2.3", "l": "\"Dihydroorotase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63168", "l": "fumarate + L-cysteine = S-(2-succino)-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19501", "l": "4-guanidinobutanoate + H2O = 4-aminobutanoate + urea"}, {"i": "EC:3.5.3.7", "l": "\"Guanidinobutyrase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052793", "l": "pectin acetylesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.-.-", "l": "\"Catalysing the translocation of inorganic cations\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33856", "l": "an inositol-1-phosphophytoceramide + GDP-alpha-D-mannose => a mannosylinositol-1-phosphophytoceramide + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035595", "l": "N-acetylglucosaminylinositol deacetylase activity"}, {"i": "RHEA:26180", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate"}, {"i": "EC:3.5.1.103", "l": "\"N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672957", "l": "PP2A dephosphorylates KSR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40048", "l": "1,2,3-trioctanoylglycerol + H2O => 1,2-dioctanoyl-sn-glycerol + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682709", "l": "LGI4 binds ADAM22,23,11 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17886", "l": "acetaldehyde => acetylene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653957", "l": "Rag dimer formation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866277", "l": "AP-2 directly binds some endocytic cargo (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19790", "l": "4-(dimethylamino)azobenzene + H2O + NADP(+) => 4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42785", "l": "adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine => 2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10502", "l": "3-ethylmalate + CoA + H(+) => butanoyl-CoA + glyoxylate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18803", "l": "(cis-prenyl)(n+1)-diphosphate + diphosphate => (cis-prenyl)n-diphosphate + isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-164834", "l": "Enzyme-bound ATP is released (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-422454", "l": "Polysialylation of NCAM1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707586", "l": "FeHM oxidises LDL,HDL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19781", "l": "2-oxoglutarate + 3,5-diiodo-L-tyrosine = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate"}, {"i": "EC:2.6.1.24", "l": "\"Diiodotyrosine transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14686", "l": "A + a primary alcohol => AH2 + an aldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432946", "l": "PARVB/Affixin interacts with alpha PIX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76052", "l": "Binding of TFIIIA To type 1 Promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49614", "l": "2-oxoglutarate + H(+) + NADH => (R)-2-hydroxyglutarate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1369028", "l": "ABCAs mediate lipid efflux (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56416", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate = alpha-D-glucose 1-phosphate + glycerol"}, {"i": "EC:2.4.1.359", "l": "\"Glucosylglycerol phosphorylase (configuration-retaining)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41340", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 = 10R-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39513", "l": "(2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671772", "l": "p-T38-PPP1R14A binds MLCP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264622", "l": "Cho is acetylated to AcCho by CHAT (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-741411", "l": "CYLD deubiquitinates NEMO (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983150", "l": "Proteasomal cleavage of substrate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29838", "l": "D-galactonate(in) + H(+)(in) <=> D-galactonate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249392", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49007", "l": "aurachin C + H(+) + NADPH + O2 <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865275", "l": "PDGF-BB clevage by Furin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49569", "l": "2-glutathionyl-2-methylbut-3-en-1-ol => (3R)-3,4-epoxy-3-methylbut-1-ene + glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38204", "l": "19-hydroxyandrost-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => 19-oxo-androst-4-ene-3,17-dione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11045", "l": "a haloacetate + H2O => a halide anion + glycolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62684", "l": "norrubrofusarin + S-adenosyl-L-methionine = H(+) + rubrofusarin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22160", "l": "4-coumaroyl-CoA + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside = a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] + CoA"}, {"i": "EC:2.3.1.173", "l": "\"Flavonol-3-O-triglucoside O-coumaroyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17980", "l": "a long-chain primary fatty alcohol + H2O + 2 NAD(+) <=> a long-chain fatty acid + 3 H(+) + 2 NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004960", "l": "thromboxane receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10826", "l": "H(+) + NADPH + oxaloacetate => (S)-malate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19019", "l": "ADP + H(+) + NADH + phosphate => (6S)-NADHX + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14234", "l": "a 2-acyl-sn-glycerol 3-phosphate + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54465", "l": "1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16364", "l": "2-acetolactate <=> 3-hydroxy-3-methyl-2-oxobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23956", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497863", "l": "The BH3 radical can decay to dihydrobiopterin (BH2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21415", "l": "NAD(+) + sn-glycerol 1-phosphate <=> dihydroxyacetone phosphate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64883", "l": "CDP + H2O <=> CMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61561", "l": "gibberellin A15 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => gibberellin A24 + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10759", "l": "ATP + phosphate + pyruvate <=> AMP + diphosphate + H(+) + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53070", "l": "4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 4-methoxyestrone + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035939", "l": "microsatellite binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018857", "l": "2,4-dichlorobenzoate-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607744", "l": "MALT1 binds BCL10 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22107", "l": "2-oxoglutarate + nicotianamine <=> 3''-deamino-3''-oxonicotianamine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209738", "l": "VD3 binds GC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24924", "l": "L-homoserine => 2-oxobutanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901602", "l": "dethiobiotin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62343", "l": "(+)-premalbrancheamide + bromide + FAD + 2 H(+) <=> (+)-malbrancheamide C + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45349", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632038", "l": "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24962", "l": "[excited state blue fluorescent protein] + CO2 => apo-[aequorin] + 3 Ca(2+) + coelenterazine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12885", "l": "GDP-alpha-D-mannose + queuosine 5'-phosphate in tRNA(Asp) = beta-D-mannosyl-5''-O-queuosine 5'-phosphate in tRNA(Asp) + GDP + H(+)"}, {"i": "EC:2.4.1.110", "l": "\"tRNA-queuosine beta-mannosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090582", "l": "protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40473", "l": "2-methyl-(2E)-pentadecenoyl-CoA + H2O2 => (2S)-methylpentadecanoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29186", "l": "menaquinol-8 + 2 O2 <=> 2 H(+) + menaquinone-8 + 2 superoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009485", "l": "IL34:CSF1 binds CSF1R (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5099899", "l": "WNT5A binds FZD4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48924", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM4 (d18:1(4E)) = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433506", "l": "Phosphorylation of APS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201629", "l": "Caspase-mediated cleavage of Tau (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047064", "l": "sulochrin oxidase [(+)-bisdechlorogeodin-forming] activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76426", "l": "N-atom dealkylation of caffeine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5679266", "l": "Beclin-1 complex translocates to the ER (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018581", "l": "hydroxyquinol 1,2-dioxygenase activity"}, {"i": "MetaCyc:HYDROXYQUINOL-12-DIOXYGENASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1370505", "l": "PRLR is phosphorylated at Ser-349 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687081", "l": "MAPK6 is ubiquitinated at the N-terminal (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57912", "l": "5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+) = H(+) + L-glutaminyl-tRNA(Gln) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63030", "l": "(15Z)-tetracosenoate + NH4(+) => (15Z)-tetracosenamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45521", "l": "[phycoerythrocyanin alpha-subunit]-Cys(84)-phycoviolobilin => (2R,3E)-phycocyanobilin + apo-[phycoerythrocyanin alpha-subunit]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31124", "l": "muconolactone => (4,5-dihydro-5-oxofuran-2-yl)-acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62993", "l": "H2O + tetradecamide => NH4(+) + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19536", "l": "2 H(+) + 2 H2O + N(2)-succinyl-L-arginine <=> CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50265", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 26-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24165", "l": "[thioredoxin]-disulfide + H2O + L-methionyl-[protein] => [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021609", "l": "ESR-associated SRC autophosphorylates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48264", "l": "H2O + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] = H(+) + S-sulfanyl-L-cysteinyl-[SoxY protein] + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39277", "l": "(15Z)-tetracosenoyl-CoA + NADP(+) => (2E,15Z)-tetracosadienoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59051", "l": "D-ornithine + H(+) <=> CO2 + putrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53172", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + ethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001018", "l": "mitochondrial promoter sequence-specific DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617862", "l": "Retinoic acid activates HOXA4 chromatin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48730", "l": "4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH => 3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-165179", "l": "Formation of TSC1:TSC2 complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674140", "l": "PAQR3 binds inactive RAFs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23307", "l": "atropine + H2O <=> H(+) + tropate + tropine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047047", "l": "oxaloglycolate reductase (decarboxylating) activity"}, {"i": "MetaCyc:1.1.1.92-RXN"}, {"i": "EC:1.1.1.92", "l": "\"Oxaloglycolate reductase (decarboxylating)\""}]}
{"type": "biolink:MolecularActivity", "ic": "64.618859499199615", "identifiers": [{"i": "GO:0015144", "l": "carbohydrate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51287", "l": "(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate <=> (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389919", "l": "Grb2 binds pBTLA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45524", "l": "[C-phycocyanin alpha-subunit]-Cys(84)-phycocyanobilin = (2R,3E)-phycocyanobilin + apo-[C-phycocyanin alpha-subunit]"}, {"i": "EC:4.4.1.32", "l": "\"C-phycocyanin alpha-cysteine-84 phycocyanobilin lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35950", "l": "dihydrochanoclavine-I aldehyde + NADP(+) <=> chanoclavine-I aldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174202", "l": "Degradation of multiubiquitinated Securin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61159", "l": "3'-dephospho-CoA + GTP <=> CoA + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36049", "l": "(R)-glycerate + AH2 + H(+) => A + D-glyceraldehyde + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58519", "l": "(19S)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] <=> 15alpha-stemmadenine intermediate I + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675790", "l": "MTORC1 dissociates from ULK complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48248", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0) = CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878054", "l": "HIPK2 phosphorylates RUNX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26130", "l": "diphosphate + isopimara-7,15-diene => (+)-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614544", "l": "Sulfite is oxidized to sulfate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43899", "l": "3beta-hydroxy-5alpha-androstan-17-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta,7alpha-dihydroxy-5alpha-androstan-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110152", "l": "RNA NAD-cap (NAD-forming) hydrolase activity"}, {"i": "RHEA:60880", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17832", "l": "A + CO + H2O <=> AH2 + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29017", "l": "phosphate(in) + sn-glycerol 3-phosphate(out) => phosphate(out) + sn-glycerol 3-phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64718", "l": "acrolein + H(+) + NADPH => NADP(+) + propanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41848", "l": "(2E)-octenoyl-[ACP] + H(+) + NADPH = NADP(+) + octanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11534", "l": "glyoxylate + H2O2 + NH4(+) => glycine + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13358", "l": "3-hydroxypropanoate + NAD(+) => 3-oxopropanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0046994", "l": "oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor"}, {"i": "EC:1.12.5.-", "l": "\"With a quinone or similar compound as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52589", "l": "choloyl-CoA + NAD(+) => 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33504", "l": "ATP + H2O + itraconazole(in) => ADP + H(+) + itraconazole(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047533", "l": "2,5-dioxovalerate dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445704", "l": "Calcium Binds Caldesmon (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25117", "l": "H2O + L-lysine + NAD(+) = (S)-2-amino-6-oxohexanoate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62503", "l": "holo-[peptidyl-carrier protein] + L-arginyl-AMP <=> AMP + H(+) + L-arginyl-[peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707594", "l": "Hemes bind LY96 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44628", "l": "L-dihydroanticapsin + NAD(+) = H(+) + L-anticapsin + NADH"}, {"i": "EC:1.1.1.385", "l": "\"Dihydroanticapsin 7-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35013", "l": "D-fucose(out) + H(+)(out) => D-fucose(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40464", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O => (9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30626", "l": "A + all-trans-neurosporene <=> AH2 + all-trans-lycopene"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047177", "l": "glycerophospholipid arachidonoyl-transferase (CoA-independent) activity"}, {"i": "RHEA:15409", "l": "1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine = 1-O-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine"}, {"i": "EC:2.3.1.147", "l": "\"Glycerophospholipid arachidonoyl-transferase (CoA-independent)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48487", "l": "a propanoate ester + H2O <=> an aliphatic alcohol + H(+) + propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4332359", "l": "Active calmodulin binds CAMK2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008679", "l": "2-hydroxy-3-oxopropionate reductase activity"}, {"i": "RHEA:18841", "l": "(R)-glycerate + NADP(+) = 2-hydroxy-3-oxopropanoate + H(+) + NADPH"}, {"i": "RHEA:18845", "l": "(R)-glycerate + NAD(+) = 2-hydroxy-3-oxopropanoate + H(+) + NADH"}, {"i": "EC:1.1.1.60", "l": "\"2-hydroxy-3-oxopropionate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56071", "l": "an N-acetyl-alpha-D-glucosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66481", "l": "gypsogenin + UDP-alpha-D-glucose => gypsogenin 28-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6795473", "l": "PDPK1 phosphorylates SGK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34195", "l": "2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 2 H(+) + O2 = 2 aureusidin 6-O-beta-glucoside + 2 H2O"}, {"i": "EC:1.21.3.6", "l": "\"Aureusidin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31546", "l": "all-trans-zeaxanthin + 2 UDP-alpha-D-glucose <=> 2 H(+) + 2 UDP + zeaxanthin bis(beta-D-glucoside)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63177", "l": "(2S)-ibuprofenoyl-CoA => (2R)-ibuprofenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112125", "l": "Oxidative dealkylation of 1-EtA damaged DNA by ABH3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9022314", "l": "HIPK2 phosphorylates MECP2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21845", "l": "L-glutamine + phenylacetyl-CoA => CoA + H(+) + N(2)-phenylacetyl-L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25934", "l": "4-methylquinolin-2(1H)-one + AH2 => 4-methylquinoline + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4411383", "l": "NLK phosphorylates TCF/LEF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48103", "l": "L-arginyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22682", "l": "dUTP + NH4(+) => dCTP + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-178208", "l": "SMAD7 binds to SMURF2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52491", "l": "O2 + prostaglandin E2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy prostaglandin E2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48028", "l": "H2O + triacetin = acetate + diacetylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22811", "l": "6-hydroxynicotinate + H2O + O2 <=> 2,6-dihydroxynicotinate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693125", "l": "RHOF binds effectors at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16311", "l": "chenodeoxycholate + taurine => H2O + taurochenodeoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45671", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798743", "l": "Exocytosis of secretory granule membrane proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64347", "l": "4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + H(+) + NADPH + O2 <=> 2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21360", "l": "ATP + beta-nicotinamide D-ribonucleotide + H(+) = diphosphate + NAD(+)"}, {"i": "EC:2.7.7.1", "l": "\"Nicotinamide-nucleotide adenylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985929", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74734", "l": "Re-integration of insulin receptor into plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807144", "l": "HTN1,HTN3 or HTN5 binds the bacterial anionic surface  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381608", "l": "cAMP activates EPAC2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20451", "l": "5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+) => 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419490", "l": "Binding of ATP to P2X receptors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202328", "l": "Translocation of PKC theta to plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676596", "l": "TRAF3 binds BAFFR:BAFF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20362", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390145", "l": "Phosphorylated HPO dimer phosphorylates SAV (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168885", "l": "Haptoglobin binds Hemoglobin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60811", "l": "gibberellin A19 + H(+) + O2 <=> CO2 + gibberellin A20 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610730", "l": "GSK3 phosphorylates p-GLI2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42042", "l": "gangliosideFuc-GM1 (d18:1(4E)) + GDP + H(+) => ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46167", "l": "a quinone + H(+) + NADPH <=> a quinol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429730", "l": "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168987", "l": "DLL4 binds NOTCH4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730872", "l": "Activation of Calcineurin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63630", "l": "AMP + diphosphate + hexadecanoyl-[ACP] => ATP + hexadecanoate + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222407", "l": "Superoxide and nitric oxide react to peroxynitrite (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26082", "l": "(2E,6E)-farnesyl diphosphate => (Z)-gamma-bisabolene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33571", "l": "A + methanol = AH2 + formaldehyde"}, {"i": "EC:1.1.99.37", "l": "\"Methanol dehydrogenase (nicotinoprotein)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13693", "l": "(6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+)"}, {"i": "EC:2.1.1.19", "l": "\"Trimethylsulfonium--tetrahydrofolate N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070678", "l": "preprotein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391152", "l": "p-4Y-SIRPA:CD47 binds PTK2B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0099186", "l": "structural constituent of postsynapse"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5655142", "l": "RCHY1 binds POLH (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111970", "l": "PKC phosphorylates GRK2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607756", "l": "TRAF6 oligomer autoubiquitinates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63748", "l": "UDP-alpha-D-glucuronate + zolasartan = UDP + zolarsartan-2-N-beta-D-glucuronide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29554", "l": "H2O + UDP-alpha-D-glucose <=> alpha-D-galactose 1-phosphate + 2 H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38085", "l": "1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71590", "l": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32597", "l": "6-hydroxy-3,7-dimethyloctanoate + H(+) => 7-isopropyl-4-methyloxepan-2-one + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57005", "l": "acetyl-CoA + streptothricin D => CoA + H(+) + N(beta)-acetylstreptothricin D"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9646468", "l": "mTORC1 binds RHEB:GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18708", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247836", "l": "Retromer recycles WLS to the Golgi (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646468", "l": "mTORC1 binds RHEB:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8980691", "l": "RHOA GEFs activate RHOA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34471", "l": "NAD(+) + propanoyl-CoA = acryloyl-CoA + H(+) + NADH"}, {"i": "EC:1.3.1.95", "l": "\"Acryloyl-CoA reductase (NADH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61173", "l": "myricetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose => H(+) + myricetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17906", "l": "(R)-glycerate + NAD(+) => 3-hydroxypyruvate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46905", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A hexaacyl 1-(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59306", "l": "adenosine 3',5'-bisphosphate + firefly L-sulfoluciferin + H(+) => 3'-phosphoadenylyl sulfate + firefly L-luciferin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046922", "l": "peptide-O-fucosyltransferase activity"}, {"i": "EC:2.4.1.221", "l": "\"Peptide-O-fucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25940", "l": "8-chloroquinoline + A + H2O = 8-chloroquinolin-2(1H)-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212432", "l": "Formation of DRIP coactivator complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33599", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + N-hexacosanoylsphinganine + O2 = 2 [Fe(III)-cytochrome b5] + H2O + N-hexacosanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36579", "l": "dTDP-alpha-D-fucose + NAD(+) = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH"}, {"i": "RHEA:36583", "l": "dTDP-alpha-D-fucose + NADP(+) = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH"}, {"i": "EC:1.1.1.266", "l": "\"dTDP-4-dehydro-6-deoxyglucose reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322427", "l": "Beta-catenin recruits CBP/p300 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10416", "l": "fumarate + toluene = 2-benzylsuccinate"}, {"i": "EC:4.1.99.11", "l": "\"Benzylsuccinate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875558", "l": "RAPGEF1 binds CRK,CRKL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52109", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA => 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31285", "l": "dihydroxyacetone phosphate + FADH2 => FAD + H(+) + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38771", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30468", "l": "(2Z,6Z)-farnesyl diphosphate => (+)-endo-beta-bergamotene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25069", "l": "(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) <=> (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9609310", "l": "β-blockers bind ADRB1,2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42020", "l": "11-dehydrocorticosterone + NAD(+) = H(+) + NADH + pregn-4-ene-3,11,20,21-tetraone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33966", "l": "ATP + isopentenyl phosphate <=> ADP + isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44297", "l": "2 H(+) + hexadecanoyl-CoA + malonyl-CoA + methylmalonyl-CoA => 4-hydroxy-5-methyl-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44975", "l": "(R)-carnitine + hexanoyl-CoA <=> CoA + O-hexanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22638", "l": "dCMP + diphosphate + H(+) => dCTP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855131", "l": "VLDLR:PCSK9 binds Clathrin-coated vesicles (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15374", "l": "columbamine + S-adenosyl-L-methionine => H(+) + palmatine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031575", "l": "AP-1 binds ARC gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675417", "l": "PEBP1 binds activated RAF1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956639", "l": "RUNX1 binds YAP1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399935", "l": "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10276", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP"}, {"i": "RHEA:37459", "l": "1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP"}, {"i": "EC:2.7.4.24", "l": "\"Diphosphoinositol-pentakisphosphate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38063", "l": "2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA = 1-dodecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29873", "l": "ADP + H(+) + phosphate + thiosulfate(in) => ATP + H2O + thiosulfate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170978", "l": "p-FRS2:CRKL binds C3G (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58663", "l": "a 5'-(5'-phosphomethyl)-ribonucleoside-RNA + S-adenosyl-L-methionine <=> a 5'-(5'-bisphosphomethyl)-ribonucleoside-RNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54713", "l": "N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine => 3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964498", "l": "DREAM complex binds the CDC6 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30974", "l": "7,7',9,9'-tetra-cis-lycopene <=> all-trans-lycopene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694462", "l": "ABHD6,12 hydrolyse 3AG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13473", "l": "H2O + L-tryptophan + NAD(+) = H(+) + indole-3-pyruvate + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59544", "l": "N,N'-diacetylchitobiose + O2 = H2O2 + N,N'-diacetylchitobiono-1,5-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433957", "l": "Activation of recruited TAK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30629", "l": "(2S)-2-acetolactate + H(+) + NADH => (2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15436", "l": "(2S)-naringenin + dimethylallyl diphosphate <=> diphosphate + sophoraflavanone B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34564", "l": "CDP-alpha-D-abequose + NADP(+) => CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56858", "l": "a carboxylate + AH2 + H(+) => A + an aldehyde + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140594", "l": "xyloglucan-specific endo-beta-1,4-glucanase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17289", "l": "beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate"}, {"i": "EC:3.1.3.46", "l": "\"Fructose-2,6-bisphosphate 2-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109858", "l": "MAP2K2 binds MAPK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57222", "l": "N(2)-(1-hydroxy-2-oxopropyl)-GTP => GTP + methylglyoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11518", "l": "CoA + H(+) + succinate => H2O + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24987", "l": "(1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52716", "l": "a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613490", "l": "Unwinding of DNA for the nascent HIV-1 transcript: Second Transition (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102305", "l": "(13E)-labda-7,13-dien-15-ol synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22929", "l": "4-acetamidobutanoyl-CoA + H2O => 4-aminobutanoyl-CoA + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35081", "l": "doxorubicin(out) => doxorubicin(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58756", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37974", "l": "H(+) + NADPH + O2 + octadecanoyl-CoA <=> (9Z)-octadecenoyl-CoA + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22065", "l": "5alpha-ergosta-7,22-diene-3beta,5-diol => ergosterol + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990943", "l": "mating type region replication fork barrier binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39862", "l": "1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycerol <=> a triacyl-sn-glycerol + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12065", "l": "5-oxopentanoate + H2O + NAD(+) => glutarate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0031883", "l": "taste receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65450", "l": "CoA + ethyl butanoate => butanoyl-CoA + ethanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29223", "l": "menaquinone-8 + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + menaquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36901", "l": "H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine => guanosine(37) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55362", "l": "9-cis-retinol => 11-cis-retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62607", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> 7-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3814820", "l": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008143", "l": "poly(A) binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70592", "l": "PXLP-K259-GOT1 dimer deaminates L-Asp (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2976551", "l": "NOTCH2 stimulates GZMB transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35677", "l": "3-oxohexadecasphinganine + CO2 + CoA => H(+) + L-serine + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047097", "l": "phylloquinone monooxygenase (2,3-epoxidizing) activity"}, {"i": "RHEA:16745", "l": "AH2 + O2 + phylloquinone = 2,3-epoxyphylloquinone + A + H2O"}, {"i": "EC:1.14.99.20", "l": "\"Phylloquinone monooxygenase (2,3-epoxidizing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626981", "l": "TNF-alpha:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42927", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48356", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66052", "l": "indole-3-pyruvate + L-kynurenine = H2O + kynurenate + L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706293", "l": "Active FLT3 binds to CBL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005362", "l": "low-affinity glucose:sodium symporter activity"}, {"i": "REACT:R-HSA-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19490", "l": "dibenzothiophene 5,5-dioxide + FMNH2 + O2 => 2'-hydroxybiphenyl-2-sulfinate + FMN-N(5)-oxide + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018494", "l": "carvone reductase activity"}, {"i": "MetaCyc:RXN-9419"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70573", "l": "argininosuccinate <=> fumarate + arginine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39071", "l": "dodecanedioyl-CoA + O2 = (2E)-dodecenedioyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45982", "l": "9alpha-hydroxy-3-oxochol-4-en-22-oyl-CoA + H2O + NAD(+) => 3-oxochol-4-en-22-oyl-CoA + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390641", "l": "ADRA1A,B,D bind ADR,NAd (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668404", "l": "TNFA binds TNFR2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003693", "l": "P-element binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689630", "l": "BAP1 binds BAP1-interacting complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693598", "l": "ATM phosphorylates NBN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34558", "l": "a (2S)-2-hydroxycarboxylate + NAD(+) <=> a 2-oxocarboxylate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40262", "l": "(2E)-hexadecenedioyl-CoA + H2O <=> (3S)-hydroxyhexadecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60204", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3204318", "l": "cob(II)alamin binds to MTRR:MTR (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666001", "l": "Profilin:G-actin binds MKL1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50333", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] => 1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17212", "l": "1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O <=> 2-formylglutarate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31126", "l": "muconolactone <=> (4,5-dihydro-5-oxofuran-2-yl)-acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13537", "l": "(2R)-3-phosphoglycerate + GDP-alpha-D-mannose = 2-O-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+)"}, {"i": "EC:2.4.1.217", "l": "\"Mannosyl-3-phosphoglycerate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14220", "l": "[thioredoxin]-disulfide + H2O + L-methionyl-[protein] <=> [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59189", "l": "L-histidine => D-histidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851919", "l": "Activated MET binds GAB1 and GRB2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371422", "l": "ATP hydrolysis by HSP70 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653745", "l": "Translation of ATF5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352893", "l": "glucose 6-phosphate <=> fructose 6-phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55257", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22295", "l": "benzoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> biphenyl-3,5-diol + 4 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1972385", "l": "ADP-Ribosylation of HNP-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25042", "l": "H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate => L-selenocysteinyl-tRNA(Sec) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.19"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10399", "l": "an L-alpha-amino acid + H2O + NAD(+) <=> a 2-oxocarboxylate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75891", "l": "Abortive Initiation After Second Transition (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901480", "l": "oleate transmembrane transporter activity"}, {"i": "RHEA:33655", "l": "(9Z)-octadecenoate(out) = (9Z)-octadecenoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34256", "l": "sporulenol => (R)-tetraprenyl-beta-curcumene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48737", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61385", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O => 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853762", "l": "RET dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46252", "l": "2 [Fe(II)-cytochrome b5] + a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427570", "l": "Group 3 - Selective Cl- transport (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17808", "l": "H2O + S-adenosyl-L-homocysteine <=> adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61774", "l": "H(+) + rebaudioside D + UDP => rebaudioside E + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26472", "l": "16-feruloyloxyhexadecanoate + CoA => (E)-feruloyl-CoA + 16-hydroxyhexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16040", "l": "phosphate + thymidine <=> 2-deoxy-alpha-D-ribose 1-phosphate + thymine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909552", "l": "Phosphorylation of STAT1 at Ser727 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30985", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-seryl-[protein] => H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913374", "l": "Phosphorylated SHC1 recruits SHIP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.20", "l": "\"Peptidyl-Lys metalloendopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373875", "l": "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65867", "l": "5alpha-androst-1-ene-3,17-dione + A + H2O <=> 5alpha-androstan-1,3,17-trione + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0000175", "l": "3'-5'-exoribonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50351", "l": "alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] <=> dolichyl diphosphate + H(+) + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14373", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674529", "l": "AAMP binds to TBXA2R (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21125", "l": "cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine => 5-methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58619", "l": "N-octanoyl-(2S)-hydroxyglycine <=> glyoxylate + octanamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44603", "l": "a fatty acid + ATP + H(+) <=> a fatty acyl-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30545", "l": "(S)-carnitinyl-CoA + ADP + phosphate => (S)-carnitine + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45768", "l": "gamma-glutamyl-L-alaninol + H2O = L-alaninol + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663363", "l": "Mechanoelectrical transduction (MET) channel transports cations into the cytosol of stereocilia of cochlear outer hair cell (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24196", "l": "(2R,4S)-2,4-diaminopentanoate + H2O + NAD(+) = (2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981610", "l": "Neuroglobin binds oxygen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54981", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose => [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n+1)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47692", "l": "AH2 + neomycin C + S-adenosyl-L-methionine = 5'-deoxyadenosine + A + H(+) + L-methionine + neomycin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444691", "l": "Prokineticin receptors bind prokineticin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866269", "l": "ARRB bind GPCRs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62510", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005135", "l": "interleukin-3 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20288", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate <=> alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10608", "l": "(E)-cinnamate + O2 + reduced [NADPH--hemoprotein reductase] = (E)-4-coumarate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.91", "l": "\"Trans-cinnamate 4-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24886", "l": "(R)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+) = D-glutamate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8963851", "l": "VD3 dissociates from GC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781953", "l": "YOD1 binds VCP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051700", "l": "fructosyl-amino acid oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199579", "l": "KIR2DL4 interacting with HLA-G (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59573", "l": "H2O + L-homocarnosine => 4-aminobutanoate + L-histidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58721", "l": "(S)-nicotine + NADPH + O2 => H2O + NADP(+) + trans-(S)-nicotine N(1')-oxide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034237", "l": "protein kinase A regulatory subunit binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102306", "l": "benzil reductase [(S)-benzoin-forming] activity"}, {"i": "EC:1.1.1.320", "l": "\"Benzil reductase ((S)-benzoin forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694487", "l": "M protein oligomerization (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20076", "l": "D-allothreonine <=> acetaldehyde + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61658", "l": "(2E,6E)-farnesyl phosphate + ADP + H(+) => (2E,6E)-farnesol + ATP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047624", "l": "adenosine-tetraphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16704", "l": "17alpha-estradiol + NAD(+) <=> estrone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847534", "l": "RAB43 hydrolyses GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24696", "l": "(E)-coniferyl acetate + NADPH => acetate + NADP(+) + trans-isoeugenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56160", "l": "an archaeal dolichyl alpha-D-glucosyl phosphate + UDP-alpha-D-glucuronate = an archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate + H(+) + UDP"}, {"i": "EC:2.4.1.356", "l": "\"Glucosyl-dolichyl phosphate glucuronosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12318", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809680", "l": "MTMR12 binds MTM1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50000", "l": "butane + H(+) + NADH + O2 = butan-1-ol + H2O + NAD(+)"}, {"i": "EC:1.14.13.230", "l": "\"Butane monooxygenase (soluble)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9690461", "l": "FKBP1A binds tacrolimus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690152", "l": "USP5 cleaves polyubiquitin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17962", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => H2O + leukotriene A4"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050183", "l": "phosphatidylcholine 12-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983841", "l": "STAT1 associates with IL6ST:IL6ST (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018768", "l": "RHOU auto-activates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.22"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59715", "l": "D-maltotetraono-1,5-lactone + H2O <=> D-maltotetraonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047800", "l": "cysteamine dioxygenase activity"}, {"i": "MetaCyc:CYSTEAMINE-DIOXYGENASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5099899", "l": "WNT5A binds FZD4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47272", "l": "monoanhydrobacterioruberin = bisanhydrobacterioruberin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000112", "l": "Endosomal TCII:Cbl translocates to lysosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.18", "l": "\"[Myosin light-chain] kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173740", "l": "Factor B binds to C3(H2O) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54123", "l": "coelenterazine h + O2 <=> coelenterazine h dioxetanone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029473", "l": "Branching and elongation of mother and daughter filaments (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654224", "l": "Activated FGFR3 binds PLCG1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0016648", "l": "oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor"}, {"i": "EC:1.5.4.-", "l": "\"With a disulfide as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23593", "l": "glycerol + NADP(+) => D-glyceraldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647978", "l": "pro-RAS proteins are farnesylated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451033", "l": "(S)-Malate <=> Fumarate + H2O (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65347", "l": "H(+) + oxidized [electron-transfer flavoprotein] + valproyl-CoA <=> (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43984", "l": "(2E,6E)-farnesol + H(+) + NADPH + O2 = (2E,6E)-omega-hydroxy-farnesol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41136", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15017", "l": "a phosphate monoester + H2O = an alcohol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47452", "l": "(2E,5Z)-tetradecadienoyl-CoA + H2O = (3S)-hydroxy-(5Z-tetradecenoyl)-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003829", "l": "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977071", "l": "Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21380", "l": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA"}, {"i": "EC:6.2.1.24", "l": "\"Phytanate--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38768", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016608", "l": "growth hormone-releasing hormone activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57076", "l": "3-oxoisoapionate 4-phosphate + H2O = 3-phosphoglycerate + glycolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390154", "l": "MATS is phosphorylated by HPO dimer and binds to phosphorylated WTS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0020037", "l": "heme binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62408", "l": "3,3'-di-O-methyl-4alpha-mannobiose + S-adenosyl-L-methionine = 1,3,3'-tri-O-methyl-4alpha-mannobiose + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.365", "l": "\"MMP 1-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807008", "l": "PTPRJ dephosphorylates MET (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948775", "l": "MKRN1 polyubiquitinates PTEN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48933", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1b => CMP + ganglioside GQ1b + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17884", "l": "H2O + N-sulfo-D-glucosamine <=> D-glucosamine + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26004", "l": "D-xylulose 5-phosphate + H(+) + NADH => D-arabinitol 1-phosphate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782943", "l": "UV-DDB ubiquitinates XPC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446391", "l": "Formation of the PINCH-ILK-parvin complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8978926", "l": "MYBL2 gene expression is inhibited by RBL1 and RBL2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35003", "l": "L-fucose(in) = L-fucose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538832", "l": "PP1 dephosphorylates phosphorylated TIM in the complex with PER and DCO (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47378", "l": "(25R)-3beta-hydroxycholest-5-en-7-one-26-al + 2 H2O + 2 oxidized [adrenodoxin] => (25R)-3beta,26-dihydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5679239", "l": "ULK complex translocates to the ER (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15782", "l": "L-tyrosine => 3-amino-3-(4-hydroxyphenyl)propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16315", "l": "5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+) => 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48566", "l": "D-ribose 5-phosphate + trans-zeatin => 9-ribosyl-trans-zeatin 5'-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-500717", "l": "Activation of GRIK3 homomer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000411", "l": "RANBP2 SUMOylates PML with SUMO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070041", "l": "rRNA (uridine-C5-)-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74711", "l": "Phosphorylation of IRS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58405", "l": "hexan-1-ol + NADP(+) => H(+) + hexanal + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102657", "l": "1-18:1-2-16:0-monogalactosyldiacylglycerol palmitoyl-lipid 7-desaturase activity"}, {"i": "RHEA:46756", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "MetaCyc:RXN-1728"}, {"i": "EC:1.14.19.42", "l": "\"Palmitoyl-[glycerolipid] 7-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11955", "l": "3-hydroxypyruvate <=> 2-hydroxy-3-oxopropanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12464", "l": "myo-inositol + UDP-alpha-D-galactose = alpha-D-galactosyl-(1->3)-1D-myo-inositol + H(+) + UDP"}, {"i": "EC:2.4.1.123", "l": "\"Inositol 3-alpha-galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57370", "l": "(6R)-NADPHX => H2O + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080016", "l": "(-)-E-beta-caryophyllene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034228", "l": "ethanolamine transmembrane transporter activity"}, {"i": "RHEA:32747", "l": "ethanolamine(in) = ethanolamine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17215", "l": "UDP-N-acetyl-alpha-D-mannosamine => UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388468", "l": "AVP(20-28) binds AVPR1A,B (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53256", "l": "5alpha-cholest-7-en-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha,8alpha-epoxy-5alpha-cholestan-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55382", "l": "a 3-oxo bile acid CoA + H(+) + NADH => a 3alpha-hydroxy bile acid CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51620", "l": "CTP + formate + H(+) = CO2 + dCTP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28543", "l": "fluoroacetyl-CoA + H2O => CoA + fluoroacetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29065", "l": "a menaquinol + CO2 => a menaquinone + formate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033983", "l": "diaminobutyrate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34855", "l": "2 H2O + iminodiacetonitrile = N-(cyanomethyl)glycine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57099", "l": "AH2 + S-methyl-1-thio-D-xylulose 5-phosphate <=> 1-deoxy-D-xylulose 5-phosphate + A + methanethiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690449", "l": "S1PR1 bind S1P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26119", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.17.7.1", "l": "\"(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.11", "l": "\"Galactosylceramide sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202164", "l": "Translocation of PDK1 to Plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852200", "l": "Inactivation of LCK by PTPN22 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61524", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 = (15S)-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33752", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210285", "l": "Trans-homophilic interaction of PECAM-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42912", "l": "cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.191", "l": "\"23S rRNA (cytosine(1962)-C(5))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65079", "l": "dauca-4,7-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> asperaculane D + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29296", "l": "aldehydo-D-galacturonate(out) + H(+)(out) => aldehydo-D-galacturonate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247915", "l": "GSH translocates from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004825", "l": "methionine-tRNA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31177", "l": "(S)-3-hydroxyisobutanoyl-CoA => (2E)-2-methylpropenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "77.349316285872916", "identifiers": [{"i": "GO:0016639", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"}, {"i": "EC:1.4.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12683", "l": "N-methylhydantoin + NH4(+) => creatinine + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031748", "l": "D1 dopamine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36864", "l": "(9Z)-octadecenoyl-CoA + AH2 + O2 => (9Z,12Z)-octadecadienoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38975", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018573", "l": "2-aminophenol 1,6-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662606", "l": "MT3 binds zinc (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57463", "l": "(E)-sinapoyl alcohol + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-trans-4-sinapoyl alcohol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16048", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21268", "l": "(R)-canadine + 2 NADP(+) = berberine + H(+) + 2 NADPH"}, {"i": "EC:1.5.1.31", "l": "\"Berberine reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60943", "l": "(9Z)-hexadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (9Z)-16-hydroxyhexadec-9-enoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197698", "l": "Src phosphorylate WASP,N-WASP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60431", "l": "(indol-3-yl)acetyl-L-aspartate + H2O <=> (indol-3-yl)acetate + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61865", "l": "AH2 + dehydroprobetaenone I => A + probetaenone I"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-453342", "l": "PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39004", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O => a 1-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875523", "l": "MET binds TNS3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63442", "l": "3-[(R)-glyceryl]-diphospho-5'-guanosine + diphosphate => (2R)-3-phosphoglycerate + GTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16135", "l": "3-aminopropanal + H2O2 + N(1)-acetylspermidine => H2O + N(1)-acetylspermine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16810", "l": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate => pyruvate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814153", "l": "ADO oxidises 2AET to HTAU (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196417", "l": "Reduction of desmosterol to cholesterol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357479", "l": "p-AXL binds PI3K (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649483", "l": "Defective PAH does not hydroxylate L-Phe to L-Tyr (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44035", "l": "9,10-epoxy-(12Z)-octadecenoate + H2O <=> 9,10-dihydroxy-(12Z)-octadecenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001515", "l": "opioid peptide activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53234", "l": "(24S)-25-epoxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesta-5,24-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53095", "l": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine <=> 2-hydroxy-3-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40379", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP = 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0052816", "l": "long-chain acyl-CoA hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0099626", "l": "voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050077", "l": "maleylpyruvate isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614811", "l": "Transcriptional Activation of the HCMV Genome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941701", "l": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864361", "l": "KCTD15 binds TFAP2 homo- and heterodimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606288", "l": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5082356", "l": "HSF1-mediated gene expression (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429036", "l": "SLC2A9 transports Fru, Glc, urate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23896", "l": "5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate"}, {"i": "EC:5.3.1.17", "l": "\"5-dehydro-4-deoxy-D-glucuronate isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59474", "l": "Gp(2'-5')Ap(3') + H(+) => 2',3'-cGAMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168923", "l": "Collagen type XVIII endostatin release (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450348", "l": "Activated human JNKs migrate to nucleoplasm (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65902", "l": "glycine + H2O + xanthurenate => 3-hydroxy-L-kynurenine + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11701", "l": "H(+) + NADPH + O2 + progesterone => H2O + NADP(+) + testosterone acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30884", "l": "D-glucurono-3,6-lactone + 2 H2O + NAD(+) => D-glucarate + 3 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54534", "l": "2-oxoglutarate + L-cysteinylglycine => H2O + N-(4-oxoglutaryl)-L-cysteinylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54262", "l": "(3S)-3-hydroxy-L-asparaginyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-asparaginyl-[protein] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614933", "l": "ACEIs bind ACE (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29277", "l": "L-isoleucine(out) + Na(+)(out) => L-isoleucine(in) + Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018575", "l": "chlorocatechol 1,2-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44327", "l": "1-butyrylglycerol + H2O <=> butanoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31034", "l": "2-cis-(+)-abscisate + UDP-alpha-D-glucose <=> beta-D-glucopyranosyl cis-(+)-abscisate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700168", "l": "Active ALK phosphorylates IRS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38121", "l": "1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018805", "l": "benzylsuccinate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49733", "l": "H(+) + O2 + violaceinate => CO2 + H2O + violacein"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25811", "l": "H2O + O2 + spermidine <=> 3-aminopropanal + H2O2 + putrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33376", "l": "a 1-acylglycerone 3-phosphate + H(+) + NADPH => a 1-acyl-sn-glycero-3-phosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928591", "l": "EPH:EFN tetramers oligomerise (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35919", "l": "2'-deamino-2'-hydroxyneamine + UDP-alpha-D-glucose = H(+) + kanamycin D + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53602", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36447", "l": "ATP + glycyl-L-proline(out) + H2O = ADP + glycyl-L-proline(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48643", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) <=> 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420117", "l": "VEGFR2 autophosphorylates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31413", "l": "a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5221061", "l": "TDG excises 5-carboxylcytosine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032142", "l": "single guanine insertion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33435", "l": "24-methylene-5alpha-cholest-8-en-3beta-ol = episterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20460", "l": "D-arabinose + NAD(+) <=> D-arabinono-1,4-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44207", "l": "2-hydroxyhexadecanoate + ATP + CoA <=> 2-hydroxyhexadecanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204600", "l": "Basigin homodimerises (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008839", "l": "BAX gene expression is stimulated by RUNX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45390", "l": "(9Z)-octadecenoate + H(+) + N-octadecanoyl-sn-glycero-3-phospho-ethanolamine => H2O + N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234166", "l": "Nuclear PHD1,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24963", "l": "apo-[aequorin] + 3 Ca(2+) + coelenterazine + O2 <=> [excited state blue fluorescent protein] + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709317", "l": "CO binds to free ferrohemoglobin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57259", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP <=> GTP + H(+) + lactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981606", "l": "Myoglobin binds oxygen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853793", "l": "p-5Y-RET complexes bind GRB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.-", "l": "\"Transaminases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9749197", "l": "ORC1 binds to H4K20me2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018621", "l": "4-sulfobenzoate 3,4-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38944", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63124", "l": "H2O + N-octadecanoyl ethanolamine = ethanolamine + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030552", "l": "cAMP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806613", "l": "Keratin tetramers bind to form unit length filaments (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015133", "l": "uronic acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198508", "l": "malate + NAD+ <=> oxaloacetate + NADH + H+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70692", "l": "ornithine => putrescine + CO2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44177", "l": "a 2,3-diacyl-sn-glycerol + H2O => 3-acyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39371", "l": "3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-167427", "l": "Opioid dissociates from MOR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25927", "l": "A + H2O + quinolin-8-ol <=> 8-hydroxyquinolin-2(1H)-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25765", "l": "3-carboxy-2-oxobutanoate + H(+) + NADH => (2R,3S)-3-methylmalate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209218", "l": "Phosphorylated DL/DIF dimer activates transcription (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40890", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H2O <=> H(+) + octadecanoate + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.5.-", "l": "\"With a quinone or similar compound as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66918", "l": "9-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389354", "l": "Activation of Vav1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637801", "l": "Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28727", "l": "Cu(2+)(in) + H(+)(in) = Cu(2+)(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47125", "l": "glycine + hexacosanoate => H2O + N-hexacosanoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63050", "l": "H(+) + pravastatin => H2O + pravastatin lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53301", "l": "D-5-[2-(methylsulfanyl)ethyl]hydantoin + H2O => H(+) + N-carbamoyl-D-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61540", "l": "ent-kaur-16-en-19-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = ent-kaur-16-en-19-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793819", "l": "HSF1 trimer binds HSE on the target gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051507", "l": "beta-sitosterol UDP-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-432054", "l": "Aquaporin-1 passively transports water out of cell (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264622", "l": "Cho is acetylated to AcCho by CHAT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19198", "l": "adenosine 5'-phosphosulfate + NH4(+) => adenosine 5'-phosphoramidate + 2 H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218805", "l": "PKC autophosphorylates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27919", "l": "H2O + NADP(+) + propanal => 2 H(+) + NADPH + propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57077", "l": "3-oxoisoapionate 4-phosphate + H2O => 3-phosphoglycerate + glycolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12826", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine => [thioredoxin]-dithiol + H(+) + phosphate + sarcosine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033872", "l": "[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity"}, {"i": "MetaCyc:2.8.2.30-RXN"}, {"i": "EC:2.8.2.30", "l": "\"[Heparan sulfate]-glucosamine 3-sulfotransferase 3\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5695964", "l": "ABHD14B hydrolyses PNPB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25448", "l": "(2E,6E)-farnesyl diphosphate = (+)-guaia-6,9-diene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944250", "l": "Association of procollagen type XXV (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050292", "l": "steroid 9-alpha-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52837", "l": "H(+) + indole + NADH + O2 => H2O + indoxyl + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008877", "l": "RUNX2:CBFB binds BGLAP gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-532603", "l": "Nephrin mediated activation of N-WASP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45654", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42595", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37972", "l": "H(+) + NADPH + O2 + octadecanoyl-CoA => (9Z)-octadecenoyl-CoA + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428750", "l": "Gq activation by TP receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798373", "l": "MDM2 ubiquitinates DYRK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008826", "l": "cysteine sulfinate desulfinase activity"}, {"i": "RHEA:28278", "l": "3-sulfino-L-alanine + H2O = H(+) + L-alanine + sulfite"}, {"i": "MetaCyc:RXN0-279"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15837", "l": "L-glutamate + methylamine = N-methyl-L-glutamate + NH4(+)"}, {"i": "EC:2.1.1.21", "l": "\"Methylamine--glutamate N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266303", "l": "Spherical HDL binds C and E apolipoproteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2106614", "l": "Duplex miRNA is loaded into Argonaute (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031867", "l": "EP4 subtype prostaglandin E2 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004667", "l": "prostaglandin-D synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10712", "l": "L-phenylalanine + O2 = 2-phenylacetamide + CO2 + H2O"}, {"i": "EC:1.13.12.9", "l": "\"Phenylalanine 2-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209924", "l": "Dopa is decarboxylated to dopamine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710354", "l": "GSDME (1-270) binds cardiolipin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66641", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + koraiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41326", "l": "(12S)-hydroperoxy-(5Z,8Z,10E)-eicosatrienoate => (5Z,8Z,11Z)-eicosatrienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18972", "l": "a long-chain fatty acid + H(+) + hnu <=> a long-chain alkane + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866269", "l": "ARRB bind GPCRs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55886", "l": "[aequorin]--dioxetanone => [aequorin] + 3 Ca(2+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13143", "l": "butanoyl-CoA => 2-methylpropanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31050", "l": "(S)-methylmalonate semialdehyde + CoA + NAD(+) <=> CO2 + NADH + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015189", "l": "L-lysine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56992", "l": "6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) = (+)-costunolide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64918", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphate => a 2'-deoxyribonucleoside 5'-triphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676589", "l": "RANKL,sRANKL trimer binds RANK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624033", "l": "Initiation of HCMV DNA Replication (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983285", "l": "RAD51B binds RAD51C (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31588", "l": "FMNH2 + NADH + O2 + uracil => (Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28380", "l": "ADP + H(+) + N(6)-(6-phospho-D-fructosyl)-L-lysine => ATP + N(6)-(D-fructosyl)-L-lysine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062076", "l": "acyl-CoA delta5-desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65951", "l": "a 2'-deoxyadenosine in DNA + acetyl-CoA + AH2 + NH4(+) + O2 <=> A + a N(6)-methylcarbamoyl-2'-deoxyadenosine in DNA + CoA + H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2529020", "l": "CK2 phosphorylates condensin I subunits (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111238", "l": "Formation of ADAR2  homodimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-196753", "l": "2xPPCS ligates PPanK with Cys (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696356", "l": "OSCAR binds collagen and SP-D (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088338", "l": "Defective GNE does not hydrolyse UDP-GlcNAc (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58147", "l": "acetate + ATP + cytidine(34) in elongator tRNA(Met) <=> AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42227", "l": "A + testosterone <=> AH2 + androst-4-ene-3,17-dione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43042", "l": "CoA + H(+) + N-hexadecanoylhexadecasphinganine => hexadecanoyl-CoA + hexadecasphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.5.-", "l": "\"Methylenetransferases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42709", "l": "guanosine(46) in tRNA + S-adenosyl-L-methionine => N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53565", "l": "9,10-epoxy-(12Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-9,10-epoxy-(12Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41444", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate + O2 = glycine + 2 H(+) + phosphate"}, {"i": "EC:1.13.11.78", "l": "\"2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13071", "l": "ADP + H(+) + phosphoethanolamine => ATP + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29639", "l": "alpha-maltohexaose + H2O = alpha-D-glucose + alpha-maltopentaose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46924", "l": "(R)-2-hydroxy-4-methylpentanoyl-CoA = 4-methylpent-2-enoyl-CoA + H2O"}, {"i": "EC:4.2.1.157", "l": "\"(R)-2-hydroxyisocaproyl-CoA dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59199", "l": "holo-[(phenol)carboxyphthiodiolenone synthase] + icosanoyl-AMP <=> AMP + H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11462", "l": "AMP + D-glucose 6-phosphate + H(+) => ADP + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668831", "l": "CST complex formation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787737", "l": "CSF3R binds CSF3 dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51333", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => 11-hydroperoxy-(8Z,12E,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63147", "l": "H2O + N-(15Z-tetracosenoyl)-ethanolamine <=> (15Z)-tetracosenoate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52679", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O <=> [amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71849", "l": "LDH tetramer reduces PYR to LACT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31805", "l": "2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H(+) + UDP => H2O + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61570", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + D-galactosamine => an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9007926", "l": "ATRX binds DAXX (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56841", "l": "5-amino-2-hydroxybenzoate + O2 => (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46324", "l": "3-oxochol-4-en-22-oyl-CoA + A = 3-oxochola-4,17-dien-22-oyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090440", "l": "abscisic acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10384", "l": "cyclo-acetoacetyl-L-tryptophan + dimethylallyl diphosphate = beta-cyclopiazonate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30054", "l": "fluoroacetate + H2O <=> fluoride + glycolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70577", "l": "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65921", "l": "L-kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32560", "l": "(2E)-geranyl diphosphate => diphosphate + gamma-terpinene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27865", "l": "3'-GMP + H2O <=> guanosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29028", "l": "2 H(+)(in) + L-glutamate(in) => 2 H(+)(out) + L-glutamate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56360", "l": "13-deoxycarminomycin + H(+) + NADPH + O2 = 13-dihydrocarminomycin + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0099101", "l": "G-protein gated potassium channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661219", "l": "MT1A binds cadmium (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21441", "l": "a long-chain fatty aldehyde + H(+) + 2 NADPH + O2 => a long-chain alkane + formate + H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60425", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + valerianol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1364044", "l": "PRLR:JAK2 dimerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213200", "l": "Release of endostatin-like peptides (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098605", "l": "selenocystathionine beta-synthase activity"}, {"i": "REACT:R-HSA-2408559", "l": "SeHCys and Ser are dehydrated into SeCysta by CBS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11018", "l": "(S)-ureidoglycolate + urea => allantoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627350", "l": "SMAC (DIABLO) binds XIAP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6793666", "l": "MDM2 translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16516", "l": "(S)-lactate + O2 <=> acetate + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83677", "l": "C4 deamination of cytidine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6805061", "l": "CK2 binds FACT (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40129", "l": "a dicarboxylate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-oxo fatty acid + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707523", "l": "Hemes bind to BACH1:MAFK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64744", "l": "H2O + S-3-(hexan-1-ol)-L-cysteine = 3-sulfanyl-1-hexanol + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11720", "l": "ATP + 2 H2O + N-methylhydantoin = ADP + 2 H(+) + N-carbamoylsarcosine + phosphate"}, {"i": "EC:3.5.2.14", "l": "\"N-methylhydantoinase (ATP-hydrolyzing)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047909", "l": "galactolipid O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0003724", "l": "RNA helicase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10270", "l": "2-hydroxy-3-oxopropanoate + pyruvate => 2-dehydro-3-deoxy-D-glucarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60753", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-jasmololone => CoA + jasmolin I"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784598", "l": "NPPA(124-151) binds NPR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52038", "l": "L-isoleucine + tuberonate => H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029680", "l": "Caspase-7 translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102139", "l": "2-hydroxy-6-oxo-6-(2'-aminophenyl)-hexa-2,4dienoate hydrolase activity"}, {"i": "RHEA:27870", "l": "(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H(+)"}, {"i": "EC:3.7.1.13", "l": "\"2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49355", "l": "2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2'-hydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9667914", "l": "ALK binds ligand midkine (MDK) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32801", "l": "urea(out) => urea(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41656", "l": "dihydrosanguinarine + NADP(+) = NADPH + sanguinarine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33105", "l": "alpha-muurolene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-870269", "l": "Gastrin binds to CCK-B receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0015125", "l": "bile acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875568", "l": "RAPGEF1 activates RAP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804402", "l": "TP53 binds POU4F1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13295", "l": "CO2 + CoA + eicosanoyl-CoA + H2O + 2 NADP(+) => 3 H(+) + malonyl-CoA + 2 NADPH + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102978", "l": "furaneol oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16308", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O <=> 3-hydroxy-3-methylglutarate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809561", "l": "I(1,3)P2 is dephosphorylated into I1P by MTMR7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63215", "l": "5-amino-6-(D-ribitylamino)uracil + methylglyoxal <=> 5-(2-oxopropylideneamino)-6-(D-ribitylamino)uracil + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047019", "l": "indole-3-acetaldehyde reductase (NADPH) activity"}, {"i": "MetaCyc:1.1.1.191-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709831", "l": "HSP90 binds TBK1 and IRF3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32646", "l": "2 [Fe(III)cytochrome c] + H2O + lupanine <=> 17-hydroxylupanine + 2 [Fe(II)cytochrome c] + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27482", "l": "(S)-columbianetin + O2 + reduced [NADPH--hemoprotein reductase] => acetone + angelicin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17193", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate"}, {"i": "EC:3.1.3.66", "l": "\"Phosphatidylinositol-3,4-bisphosphate 4-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849094", "l": "ARHGAP35 binds RASA1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-429101", "l": "HMIT co-transports myo-inositol with a proton (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52097", "l": "9-octadecanoyloxy-octadecanoate + H2O => 9-hydroxy-octadecanoate + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58128", "l": "A + O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine = AH2 + alstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047327", "l": "glycerol-3-phosphate-glucose phosphotransferase activity"}, {"i": "KEGG.REACTION:R00850"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58362", "l": "(5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-lysyl-[protein] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875568", "l": "RAPGEF1 activates RAP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163090", "l": "Elongation Of The Telomeric Chromosome End (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58043", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700662", "l": "(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35273", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52229", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 => 3 A + biliverdin beta + CO + Fe(2+) + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002170", "l": "high-affinity IgA receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169919", "l": "Glycosylation of NA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008798", "l": "beta-aspartyl-peptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57695", "l": "2 cob(II)inamide--[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] <=> 2 cob(I)inamide--[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37597", "l": "1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25096", "l": "ADP + dCDP => ATP + dCMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675417", "l": "PEBP1 binds activated RAF1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63719", "l": "losartan + UDP-alpha-D-glucuronate <=> losartan-1-N-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44857", "l": "(9Z)-octadecenoyl-CoA + (R)-carnitine => CoA + O-(9Z)-octadecenoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31968", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] => ent-11beta-hydroxycassa-12,15-diene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061656", "l": "SUMO conjugating enzyme activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034452", "l": "dynactin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34836", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-4-hydroxy-15-methylhexadecasphinganine => a 1,2-diacyl-sn-glycerol + N-acyl-4-hydroxy-15-methylhexadecasphinganine-1-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876789", "l": "CARNMT1 methylates CARN to Anserine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49195", "l": "calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788974", "l": "Hypochlorous acid and nitrite react to nitryl chloride (NO2Cl) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14850", "l": "H2O + N-amidino-L-aspartate => L-aspartate + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53236", "l": "cholesta-5,24-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = cholesta-5,24Z-dien-3beta,27-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60020", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + sesquisabinene A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44301", "l": "2 H(+) + malonyl-CoA + methylmalonyl-CoA + octadecanoyl-CoA => 4-hydroxy-5-methyl-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13491", "l": "berberine + 2 H2O2 => (S)-canadine + H(+) + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67005", "l": "a 5'-end triphospho-ribonucleoside in mRNA + H2O => a 5'-end diphospho-ribonucleoside in mRNA + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44210", "l": "12-methyltridecanoyl-CoA + AMP + diphosphate => 12-methyltridecanoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1006169", "l": "Factor H binds host cell surface markers (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65512", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + O2 = 5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52080", "l": "12-octadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140605", "l": "proton motive force-driven motor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371435", "l": "Constitutive phosphorylation by GSK3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21269", "l": "(R)-canadine + 2 NADP(+) => berberine + H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211224", "l": "Association of DFF40 with DFF45 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49114", "l": "5-methyl-phenazine-1-carboxylate + S-adenosyl-L-homocysteine => phenazine-1-carboxylate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37383", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12660", "l": "a (2S)-2-methylacyl-CoA <=> a (2R)-2-methylacyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22190", "l": "a (2S)-2-hydroxycarboxylate + a halide anion + H(+) => an (R)-2-haloacid + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034559", "l": "bisphenol A hydroxylase B activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426161", "l": "SREBP1A,2 binds the GGPS1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10804", "l": "(S)-allantoin = (R)-allantoin"}, {"i": "EC:5.1.99.3", "l": "\"Allantoin racemase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69142", "l": "Recruitment of Dna2 endonuclease (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.58", "l": "\"Longifolene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66498", "l": "alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => GDP-alpha-D-rhamnose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12127", "l": "4-coumaroyl-CoA + shikimate <=> CoA + trans-4-coumaroylshikimate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69116", "l": "Formation of Okazaki fragments (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35843", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-3-phosphoethanolamine + a cardiolipin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55936", "l": "all-trans-4-hydroxyretinol + NAD(+) = all-trans-4-hydroxyretinal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44670", "l": "4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+) => 4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59800", "l": "decanoyl-CoA + L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] = CoA + H(+) + N(6)-decanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5368586", "l": "DKK promotes clathrin-dependent internalization of LRP6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2317314", "l": "AKT binds PDPK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202127", "l": "eNOS synthesizes NO (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54838", "l": "H2O + NADP(+) + pentyl acetate => H(+) + heptan-2-one + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13618", "l": "H2O + S-methyl-5'-thioadenosine => 5-(methylsulfanyl)-D-ribose + adenine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008993", "l": "rhamnulokinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59150", "l": "AMP + diphosphate + marinoloyl-CoA C => ATP + CoA + marinolate C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102156", "l": "2,5-DHBA UDP-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-11705"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51378", "l": "CoA + H(+) + N-hexadecanoyl-dopamine => dopamine + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.207", "l": "\"tRNA (cytidine(34)-2'-O)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53872", "l": "CTP + D-ribose 5-phosphate + H(+) = CDP-D-ribose + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57269", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP => GMP + H(+) + lactate"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0008263", "l": "pyrimidine-specific mismatch base pair DNA N-glycosylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9008052", "l": "IL1F10(?-152) binds IL1RAPL1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174070", "l": "Association of Cdh1 with the APC/C (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12817", "l": "2,3-dihydrobiochanin A + NADP(+) = biochanin A + 2 H(+) + NADPH"}, {"i": "EC:1.3.1.46", "l": "\"Biochanin-A reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29502", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-alpha-barbatene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654515", "l": "KAL1 binds HS (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-996755", "l": "ZFPM proteins bind GATA proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55784", "l": "all-trans-4-oxoretinoate + UDP-alpha-D-glucuronate = all-trans-4-oxoretinoate 1-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333608", "l": "GSSebGalNac is reduced and methylated to MeSebGalNac (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32066", "l": "8-oxo-dGDP + H2O <=> 8-oxo-dGMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57740", "l": "a 2,3-saturated meromycolyl-[ACP] + NAD(+) = a trans-Delta(2)-meromycolyl-[ACP] + H(+) + NADH"}, {"i": "EC:1.3.1.118", "l": "\"Meromycolic acid enoyl-[acyl-carrier-protein] reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62599", "l": "(S)-8-oxocitronellyl enol + NAD(+) <=> (6E)-8-oxogeranial + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015180", "l": "L-alanine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187332", "l": "Cytosolic CMs translocate to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35515", "l": "4'''-demalonylsalvianin + malonyl-CoA = CoA + salvianin"}, {"i": "EC:2.3.1.214", "l": "\"Pelargonidin 3-O-(6-caffeoylglucoside) 5-O-(6-O-malonylglucoside) 4'''-malonyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035242", "l": "protein-arginine omega-N asymmetric methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11502", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate => 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.175", "l": "\"D-xylose 1-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022828", "l": "phosphorylation-gated channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26386", "l": "all-trans-8'-apo-beta-carotenal + O2 => (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626270", "l": "Defective SLC24A4 does not exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004687", "l": "myosin light chain kinase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0071813", "l": "lipoprotein particle binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29109", "l": "NAD(+) + ubiquinol-8 => H(+) + NADH + ubiquinone-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43095", "l": "S-adenosyl-L-methionine + uridine(2479) in 23S rRNA <=> 2'-O-methyluridine(2479) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11294", "l": "H2O2 + rifamycin O => 2 H(+) + O2 + rifamycin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805811", "l": "Release of SEPT4 from mitochondria (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56423", "l": "apo-[D-alanyl-carrier protein] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[D-alanyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49950", "l": "(10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2 => (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61048", "l": "lochnericine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + horhammericine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33732", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + a cardiolipin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12138", "l": "a (2E,4E)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(2E)-enoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4332363", "l": "Autophosphorylation and activation of CAMK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24973", "l": "calcitetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (1S)-1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35477", "l": "(S)-5'-oxoaverantin + H(+) + NADH => (1'S,5'S)-5'-hydroxyaverantin + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551727", "l": "CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23079", "l": "4-chlorobenzoyl-CoA + chloride + NADP(+) <=> 2,4-dichlorobenzoyl-CoA + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19784", "l": "2-oxoglutarate + 3,5-diiodo-L-tyrosine <=> 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912396", "l": "NICD1 binds HIF1A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65670", "l": "a diacylglycerol + an N-(32-(9Z,12Z-octadecadienoyloxy)-dotriacontenoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013110", "l": "RHOC binds effectors at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50804", "l": "glutathione + prostaglandin J2 = prostaglandin J2-S-(R)-glutathione"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016847", "l": "1-aminocyclopropane-1-carboxylate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61028", "l": "itaconate + L-cysteinyl-[protein] = S-(2,3-dicarboxypropyl)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031624", "l": "ubiquitin conjugating enzyme binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30227", "l": "2 [Fe(III)-cytochrome c2] + dimethyl sulfide + H2O = 2 [Fe(II)-cytochrome c2] + dimethyl sulfoxide + 2 H(+)"}, {"i": "EC:1.8.2.4", "l": "\"Dimethyl sulfide:cytochrome c2 reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421454", "l": "Transport of protoporphyrin IX from the mitochondrial intermembrane space into the mitochondrial matrix (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047119", "l": "2-methyl-branched-chain-enoyl-CoA reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56060", "l": "H(+) + hexadecanoate + hnu = CO2 + pentadecane"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6790038", "l": "Expression of HSP90B1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54970", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + phosphate => hexadecanoyl phosphate + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16187", "l": "a carboxylate + 2 H(+) + NADH => an aldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694345", "l": "Nucleoprotein translocates to the nucleolus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53262", "l": "1beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050153", "l": "omega-hydroxydecanoate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60023", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + sesquisabinene A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16675", "l": "H(+) + phosphate + pyruvate => 3-phosphonopyruvate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32911", "l": "sn-glycerol 3-phosphocholine(out) = sn-glycerol 3-phosphocholine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33624", "l": "ATP + CoA + dodecanoate => AMP + diphosphate + dodecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63272", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 = 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60401", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37340", "l": "3-(carbamoylamino)-2-methylpropanoate + 2 H(+) + H2O => (R)-3-amino-2-methylpropanoate + CO2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17199", "l": "2 4-hydroxyphenylacetate + 2 CO2 => 2 3-(4-hydroxyphenyl)pyruvate + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031845", "l": "type 5 neuropeptide Y receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22733", "l": "4-hydroxyphenylacetate + H(+) => 4-methylphenol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791228", "l": "45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22263", "l": "H2O + triacetate lactone <=> H(+) + triacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22754", "l": "AH2 + barbiturate + H(+) => A + H2O + uracil"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036470", "l": "tyrosine 3-monooxygenase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55482", "l": "ent-3beta-hydroxycassa-12,15-dien-2-one + 3 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948775", "l": "MKRN1 polyubiquitinates PTEN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052598", "l": "histamine oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24188", "l": "cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) = 1,2-dihydroxydibenzothiophene + H(+) + NADH"}, {"i": "EC:1.3.1.60", "l": "\"Dibenzothiophene dihydrodiol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102456", "l": "cyanidin 3-O-glucoside 5-O-glucosyltransferase (sinapoyl-glucose dependent) activity"}, {"i": "MetaCyc:RXN-13967"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65201", "l": "S-(acetaldehyde)-L-cysteine => (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17223", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O => dTDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8963851", "l": "VD3 dissociates from GC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21738", "l": "(3S,5S)-3,5-diaminohexanoate => (3S)-3,6-diaminohexanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018612", "l": "dibenzothiophene dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44465", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol => 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10209", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) => H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60709", "l": "(1R,3R)-chrysanthemal + H2O + NAD(+) => (1R,3R)-chrysanthemate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8934465", "l": "SHC1 binds PTPN12 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033938", "l": "1,6-alpha-L-fucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050070", "l": "lysolecithin acylmutase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-182988", "l": "Sprouty lures CBL away from EGFR (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12009", "l": "[G-protein-coupled receptor] + ATP => [G-protein-coupled receptor]-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730840", "l": "Activation of RAC1 by VAV (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5653957", "l": "Rag dimer formation (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696268", "l": "RND3 binds effectors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33313", "l": "2 AH2 + H(+) + H2O + N2 => 2 A + hydroxylamine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29219", "l": "a menaquinone + sn-glycerol 3-phosphate = a menaquinol + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786070", "l": "IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.44"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56465", "l": "1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O => 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29143", "l": "a ubiquinol + 2 H(+)(in) + nitrate = a ubiquinone + 2 H(+)(out) + H2O + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610723", "l": "GLI proteins bind SUFU (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28111", "l": "chloride + S-adenosyl-L-methionine => 5'-chloro-5'-deoxyadenosine + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60242", "l": "CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "75.076548671259488", "identifiers": [{"i": "GO:0016641", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017113", "l": "dihydropyrimidine dehydrogenase (NADP+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668335", "l": "CHMP7 binds LEMD2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10522", "l": "1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700179", "l": "Ligand-independent dimerization of ALK fusions (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2859050", "l": "Hydrolysis of C4b (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31996", "l": "(2E,6E)-farnesyl diphosphate => 7-epi-sesquithujene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31192", "l": "(3S)-hydroxydecanoyl-CoA => (2E)-decenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853405", "l": "TPX2 binds AURKA at centrosomes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046422", "l": "violaxanthin de-epoxidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047128", "l": "1,2-dehydroreticulinium reductase (NADPH) activity"}, {"i": "RHEA:17569", "l": "(R)-reticuline + NADP(+) = 1,2-dehydroreticuline + H(+) + NADPH"}, {"i": "EC:1.5.1.27", "l": "\"1,2-dehydroreticulinium reductase (NADPH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19792", "l": "4-(dimethylamino)azobenzene + H2O + NADP(+) <=> 4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375140", "l": "CDO binds promyogenic cadherins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028583", "l": "Phosphorylation of YAP by LATS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004937", "l": "alpha1-adrenergic receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42780", "l": "adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.183", "l": "\"18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61399", "l": "ATP + N(6)-(D-erythrulosyl)-L-lysyl-[protein] <=> ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9726848", "l": "SRC phosphorylates RHOU (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13147", "l": "alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine => 4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691131", "l": "CANDI binds CUL1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47093", "l": "(S)-2,3-dihydrodipicolinate + NADP(+) => dipicolinate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19154", "l": "apigenin 7-O-beta-D-glucoside + UDP-alpha-D-apiose => 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60134", "l": "a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate => a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44182", "l": "(2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein] => 2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205319", "l": "Interaction of APS and p-KIT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29461", "l": "beta-alanine(out) + H(+)(out) => beta-alanine(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801101", "l": "RABGGTA binds RABGGTB (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44334", "l": "ADP + bacilysin + H(+) + phosphate => ATP + L-alanine + L-anticapsin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5660662", "l": "ASC binds Caspase-8 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29943", "l": "2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in) = 2-dehydro-3-deoxy-D-gluconate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209157", "l": "Phosphorylated BSK kinase is dephosphorylated and deactivated by PUC phosphatase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17436", "l": "A + choline <=> AH2 + betaine aldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35706", "l": "1'-hydroxyversicolorone + H(+) + NADPH + O2 <=> (2S,3S)-versiconal hemiacetal acetate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21810", "l": "glycylglycine => 2,5-dioxopiperazine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36044", "l": "all-trans-8'-apo-beta-carotenal + O2 => 13-apo-beta-carotenone + 2,6-dimethyldeca-2,4,6,8-tetraenedial"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102144", "l": "carboxyspermidine dehydrogenase II activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800490", "l": "ATM phosphorylates PIDD1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042809", "l": "vitamin D receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37879", "l": "methyl aklanonate = aklaviketone"}, {"i": "EC:5.5.1.23", "l": "\"Aklanonic acid methyl ester cyclase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65477", "l": "1-propanol + butanoyl-CoA => CoA + propyl butanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10751", "l": "H(+) + hydrogencarbonate <=> CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27689", "l": "ATP + GDP <=> ADP + GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50026", "l": "adenosine 3',5'-bisphosphate + dodecanoyl-4'-phosphopantetheine + 2 H(+) => dodecanoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879910", "l": "JAK2 is phosphorylated, activated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416358", "l": "G alpha (q) inhibits PI3K alpha (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191830", "l": "snRNP nuclear import and release (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250264", "l": "TXNIP binds reduced thioredoxin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0019788", "l": "NEDD8 transferase activity"}, {"i": "REACT:R-HSA-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102388", "l": "UDP-N,N'-diacetylbacillosamine 2-epimerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404134", "l": "RBP4:atROL binds TTR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23109", "l": "D-arabinono-1,4-lactone + H2O => D-arabinonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31416", "l": "(2Z,6E)-farnesyl diphosphate => (+)-2-epi-prezizaene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0071771", "l": "aldehyde decarbonylase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004447", "l": "iodide peroxidase activity"}, {"i": "MetaCyc:IODIDE-PEROXIDASE-RXN"}, {"i": "EC:1.11.1.8", "l": "\"Iodide peroxidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046608", "l": "carotenoid isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65962", "l": "ADP + H(+) + leukotriene C4(in) + phosphate => ATP + H2O + leukotriene C4(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45974", "l": "9alpha-hydroxy-3-oxochol-4-en-22-oate + H2O + NAD(+) => 3-oxochol-4-en-22-oate + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853405", "l": "TPX2 binds AURKA at centrosomes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46450", "l": "cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr) => 2 L-tyrosyl-tRNA(Tyr)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41067", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.372", "l": "\"D/L-glyceraldehyde reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20100", "l": "D-mannonate <=> 2-dehydro-3-deoxy-D-gluconate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43399", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53617", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-isoafricanol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483219", "l": "PC is exchanged with PI by PITPNB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30781", "l": "2-dehydro-D-gluconate + FADH2 => D-gluconate + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62846", "l": "beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-D-glucosamine + GDP + H(+) => beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655170", "l": "RCHY1 monoubiquitinates POLH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11469", "l": "(S)-3-methyl-2-oxopentanoate + L-valine => 3-methyl-2-oxobutanoate + L-isoleucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50275", "l": "(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O <=> resolvin E1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24273", "l": "H(+) + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2 => H2O + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18887", "l": "GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH => GDP-beta-L-fucose + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17290", "l": "beta-D-fructose 2,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41816", "l": "ganglioside GD3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GD2 (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54596", "l": "2-oxoglutarate + hexadecanoyl-CoA + O2 = 2-hydroxyhexadecanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60196", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(9)-[histone H3] + O2 = CO2 + formaldehyde + L-lysyl(9)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18652", "l": "D-galactonate <=> 2-dehydro-3-deoxy-D-galactonate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10054", "l": "4-methyl-2-oxopentanoate + H(+) + NADH => (R)-2-hydroxy-4-methylpentanoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008676", "l": "3-deoxy-8-phosphooctulonate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35713", "l": "acetyl-CoA + succinate => acetate + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42110", "l": "H(+) + NADH + progesterone => (20S)-hydroxypregn-4-en-3-one + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16540", "l": "(9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O <=> (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56014", "l": "beta-D-mannose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030280", "l": "structural constituent of skin epidermis"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61175", "l": "myricetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> H(+) + myricetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801101", "l": "RABGGTA binds RABGGTB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64161", "l": "ATP + glycyl-[methyl-coenzyme M reductase] + hydrogen sulfide => ADP + phosphate + thioglycyl-[methyl-coenzyme M reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45303", "l": "an N-(acyl)-sphingosylphosphocholine + H2O <=> an N-acyl-sphingoid base + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16218", "l": "H2O + L-arabinono-1,4-lactone => H(+) + L-arabinonate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030504", "l": "inorganic diphosphate transmembrane transporter activity"}, {"i": "REACT:R-HSA-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0001681", "l": "sialate O-acetylesterase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009002", "l": "serine-type D-Ala-D-Ala carboxypeptidase activity"}, {"i": "MetaCyc:3.4.16.4-RXN"}, {"i": "EC:3.4.16.4", "l": "\"Serine-type D-Ala-D-Ala carboxypeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798044", "l": "BTG2 binds CCR4-NOT complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851888", "l": "MET binds SHC1-2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29946", "l": "2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in) <=> 2-dehydro-3-deoxy-D-gluconate(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38658", "l": "6-tuliposide B <=> D-glucose + tulipalin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35997", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47672", "l": "H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+) = 2''-O-malonyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13865", "l": "GDP-alpha-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol = beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)"}, {"i": "EC:2.4.1.142", "l": "\"Chitobiosyldiphosphodolichol beta-mannosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.194"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15151", "l": "H2O2 + pyridoxal 5'-phosphate => O2 + pyridoxine 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43237", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O => 1,2-dihexadecanoyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247843", "l": "secretion of WNT ligands (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018808", "l": "RAC3 binds effectors at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033881", "l": "bile-acid-CoA hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972956", "l": "POU5F1 (OCT4), SOX2, NANOG bind the STAT3 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5631941", "l": "SESN1,2,3 bind AMPK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35026", "l": "hydroquinone O-beta-D-glucopyranoside(out) <=> hydroquinone O-beta-D-glucopyranoside(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38348", "l": "(S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate => 2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18506", "l": "L-lysine + NAD(+) => Delta(1)-piperideine-2-carboxylate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2545253", "l": "Deacetylation of cohesin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134954", "l": "DHX9 binds DNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102493", "l": "wogonin 7-O-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-14239"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52153", "l": "(E)-2-(1H-indol-3-yl)-1-thioacetohydroximate + UDP-alpha-D-glucose => indolylmethyl-desulfoglucosinolate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109813", "l": "GRB2-1 binds SOS1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19677", "l": "9'-cis-neoxanthin + O2 = (3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45673", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12484", "l": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate"}, {"i": "EC:3.1.3.5", "l": "\"5'-nucleotidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42531", "l": "uridine(955/2504/2580) in 23S rRNA <=> pseudouridine(955/2504/2580) in 23S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2129357", "l": "Fibrillin C-terminal processing (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3134883", "l": "Beta-catenin enhances association of IRF3 with CBP/p300  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-555065", "l": "Formation of clathrin coated vesicle (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692761", "l": "JUN binds MAPK6 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10661", "l": "L-seryl-[protein] => D-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24393", "l": "dTDP-L-dihydrostreptose + streptidine 6-phosphate => dTDP + H(+) + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700662", "l": "(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10560", "l": "4-hydroxy-1-pyrroline-2-carboxylate + H(+) + H2O = 2,5-dioxopentanoate + NH4(+)"}, {"i": "EC:3.5.4.22", "l": "\"1-pyrroline-4-hydroxy-2-carboxylate deaminase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106361", "l": "protein-arginine rhamnosyltransferase activity"}, {"i": "RHEA:66692", "l": "dTDP-beta-L-rhamnose + L-arginyl-[protein] = dTDP + H(+) + N(omega)-(alpha-L-rhamnosyl)-L-arginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29798", "l": "ATP(in) + H2O(in) + Zn(2+)(out) <=> ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247840", "l": "WLS binds WNT ligands in the Golgi (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15631", "l": "an 11beta-hydroxysteroid + H2O + 2 oxidized [adrenodoxin] => a steroid + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391905", "l": "Oxoeicosanoid receptor can bind oxoeicosanoid (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16360", "l": "A + succinate <=> AH2 + fumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788623", "l": "p-Y-STATs translocate to nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.1.2", "l": "\"Hydrogen dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191299", "l": "Squalene is oxidized to its epoxide (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23338", "l": "diiodine + 2 H2O => 2 H(+) + H2O2 + 2 iodide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35640", "l": "(4S)-4-hydroxy-2-oxoglutarate => glyoxylate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18704", "l": "arsenite + H2O + 2 oxidized [azurin] <=> arsenate + 3 H(+) + 2 reduced [azurin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59921", "l": "(2E)-octenal + H2O + NAD(+) => (2E)-octenoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853890", "l": "VENTX binds the IL6 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6795667", "l": "MDM2 translocates to the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036408", "l": "histone acetyltransferase activity (H3-K14 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47307", "l": "(9Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,9Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32883", "l": "(11R)-dihydroartemisinic aldehyde + NADP(+) = (+)-artemisinic aldehyde + H(+) + NADPH"}, {"i": "EC:1.3.1.92", "l": "\"Artemisinic aldehyde Delta(11(13)) reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31087", "l": "acetyl-CoA + octanoyl-CoA = 3-oxodecanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23874", "l": "(R)-lactaldehyde + H(+) + NADH => (R)-propane-1,2-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008704", "l": "5-carboxymethyl-2-hydroxymuconate delta-isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693598", "l": "ATM phosphorylates NBN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20129", "l": "AMP + H2O = adenine + D-ribose 5-phosphate"}, {"i": "EC:3.2.2.4", "l": "\"AMP nucleosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811454", "l": "MAPKs phosphorylate PP2A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46224", "l": "(E)-feruloyl-CoA + H2O = (E)-ferulate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52141", "l": "(DNA)-3'-diphospho-5'-guanosine + H2O => (DNA)-3'-phosphate + GMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.-.-", "l": "\"Transferring alkyl or aryl groups, other than methyl groups\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9681375", "l": "KIT binds ripretinib (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592436", "l": "Initial activation of proMMP9 by MMPs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15545", "l": "(3S)-citramalate = acetate + pyruvate"}, {"i": "EC:4.1.3.22", "l": "\"Citramalate lyase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004965", "l": "G protein-coupled GABA receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59844", "l": "(+)-dehydrodiconiferyl alcohol + H(+) + NADPH = (R)-isodihydrodehydrodiconiferyl alcohol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37916", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50324", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807106", "l": "PTEN undergoes monoubiquitination (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202960", "l": "Caspase mediated cleavage of C-IAP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114284", "l": "Release of Cytochrome c from mitochondria (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66613", "l": "N(6)-carboxybiotinyl-L-lysyl-[protein] + propanoyl-CoA => methylmalonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003920", "l": "GMP reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614605", "l": "Persulfide sulfur is dioxygenated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8962039", "l": "TK1 gene expression is stimulated by E2F1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781897", "l": "USP11 deubiquitinates NFKBIA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51825", "l": "ATP(in) + CoA(in) + H(+)(out) + octanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + octanoyl-CoA(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49411", "l": "[(1->2)-beta-D-mannosyl](n) + phosphate <=> [(1->2)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174916", "l": "Formation of N-glucuronides (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606622", "l": "GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47110", "l": "H2O + taurocholate => cholate + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396370", "l": "VTN binds collagens II, III and V (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388560", "l": "EDNRA,EDNRB bind EDNs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687284", "l": "DMBT1 binds SFTPD 12mer, SFTPAs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614605", "l": "Persulfide sulfur is dioxygenated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47914", "l": "2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O => 6-deoxy-6-sulfo-D-gluconate"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0004181", "l": "metallocarboxypeptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60228", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0016504", "l": "peptidase activator activity"}, {"i": "REACT:R-HSA-168865", "l": "NA activation of TGF-beta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109702", "l": "PDPK1 phosphorylates AKT2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43119", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + N-octanoylsphinganine + O2 <=> 2 [Fe(III)-cytochrome b5] + H2O + N-octanoyl-4-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42362", "l": "keto-D-fructose => D-allulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41337", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0016211", "l": "ammonia ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42852", "l": "3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine = (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.3.1.244", "l": "\"2-methylbutanoate polyketide synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693012", "l": "TNFSF15 binds TNFRSF25 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37197", "l": "1-octadecanoyl-sn-glycero-3-phosphate + CoA => octadecanoyl-CoA + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54392", "l": "1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004760", "l": "serine-pyruvate transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.54", "l": "\"Mucrolysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.36", "l": "\"Pancreatic elastase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18225", "l": "[N-(6-aminohexanoyl)](n) + H2O = 6-aminohexanoate + [N-(6-aminohexanoyl)](n-1)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29162", "l": "3 a menaquinol(in) + 2 H(+)(out) + nitrite(out) <=> 3 a menaquinone(in) + 2 H2O(out) + NH4(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15886", "l": "NADP(+) + propane-1,2-diol => (S)-lactaldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.29"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621073", "l": "Immediate Early (IE) Gene Expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18004", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a carboxylate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60066", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + H2O + NAD(+) => a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48983", "l": "3,4-dichlorocatechol + O2 <=> (2Z,4Z)-2,3-dichloromuconate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-947514", "l": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52603", "l": "L-methionine + propanoyl-CoA <=> CoA + H(+) + N-propanoyl-L-methioninate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11010", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate => a 5'-end triphospho-(purine-ribonucleoside) in mRNA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67087", "l": "ATP + H2O + hexacosanoate(in) <=> ADP + H(+) + hexacosanoate(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45488", "l": "[C-phycocyanin beta-subunit]-Cys(84)-phycocyanobilin = (2R,3E)-phycocyanobilin + apo-[C-phycocyanin beta-subunit]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53184", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21537", "l": "(3S)-hydroxy-3-methylglutaryl-CoA => H2O + trans-3-methylglutaconyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.1.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.47", "l": "\"HIV-2 retropepsin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55590", "l": "a 1,2-diacyl-sn-glycerol + an inositol-1-phosphoceramide => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-sphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50436", "l": "prostaglandin H1 = prostaglandin E1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678694", "l": "Heparanase 2 (HPSE2) cleaves heparan sulfate from its proteoglycan (plasma membrane) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31457", "l": "2 H(+) + NADH + riboflavin => NAD(+) + reduced riboflavin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42826", "l": "H2O + 2 NAD(+) + tetracenomycin C => 2 H(+) + 2 NADH + 2 O2 + tetracenomycin A2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045435", "l": "lycopene epsilon cyclase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39161", "l": "(2E)-hexadecenoyl-CoA + H2O => (3R)-hydroxyhexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20112", "l": "alpha-D-ribose 1,5-bisphosphate + ATP <=> 5-phospho-alpha-D-ribose 1-diphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061891", "l": "calcium ion sensor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0044769", "l": "ATPase activity, coupled to transmembrane movement of ions, rotational mechanism"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42579", "l": "2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + H2O <=> 2-methylpropanoate + 2-oxopent-4-enoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19564", "l": "androst-4-ene-3,17-dione + H(+) + NADPH + O2 <=> H2O + NADP(+) + testololactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1237160", "l": "MTA is cleaved and phosphorylated (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65057", "l": "glycochenodeoxycholate + NADP(+) => 7-oxoglycolithocholate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015526", "l": "hexose-phosphate:inorganic phosphate antiporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015400", "l": "low-affinity secondary active ammonium transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800490", "l": "ATM phosphorylates PIDD1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156930", "l": "GTP-binding activates eEF2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-171106", "l": "LDLR:LDL complex => LDLR + LDL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34348", "l": "(2E)-geraniol + NAD(+) => (2E)-geranial + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33881", "l": "3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH => 2-deoxy-scyllo-inosamine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37816", "l": "(R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 => 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0046977", "l": "TAP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16765", "l": "D-mannitol + NADP(+) = D-fructose + H(+) + NADPH"}, {"i": "EC:1.1.1.138", "l": "\"Mannitol 2-dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50715", "l": "chloride + FADH2 + O2 + tetracycline <=> 7-chlorotetracycline + FAD + H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045550", "l": "geranylgeranyl reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18861", "l": "a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine = a 5-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004325", "l": "ferrochelatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28005", "l": "beta-D-fructose 6-phosphate <=> D-glyceraldehyde 3-phosphate + dihydroxyacetone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9634834", "l": "ACHEIs bind ACHE (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48607", "l": "2,3-dihydroxybenzoyl-5'-AMP + holo-[EntB isochorismatase/aryl-carrier protein] <=> 2,3-dihydroxybenzoyl-[EntB isochorismatase/aryl-carrier protein] + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44198", "l": "3-methylundecanoyl-CoA + AMP + diphosphate => 3-methylundecanoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214859", "l": "Activated PLL kinase is autophosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52373", "l": "17beta-estradiol + 3'-phosphoadenylyl sulfate => 17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56237", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20710", "l": "ADP + D-erythritol 4-phosphate + H(+) => ATP + erythritol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29068", "l": "formate + H(+) + menaquinone-8 => CO2 + menaquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5334794", "l": "FABPs bind LCFAs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685607", "l": "Sialic acid binds SIGLEC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380508", "l": "Translocation of NuMA to the centrosomes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878186", "l": "CDKN1A gene expression is synergistically activated by RUNX3, SMAD3 and SMAD4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29090", "l": "(S)-malate + menaquinone-8 <=> menaquinol-8 + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37061", "l": "AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA => adenosine(37) in tRNA + L-threonylcarbamoyladenylate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043920", "l": "aminopropylagmatine ureohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1067640", "l": "IL6 binds IL6R-2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982645", "l": "GRKs bind ADRB2:Catecholamine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676912", "l": "Methionine is oxidised to methionine sulfoxide (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624624", "l": "FBXO32 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-555065", "l": "Formation of clathrin coated vesicle (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51375", "l": "(9Z)-hexadecenoyl-CoA + glycine <=> CoA + H(+) + N-(9Z-hexadecenoyl)-glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43048", "l": "keto-D-tagatose = keto-D-sorbose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849428", "l": "PTPN1 binds PTK6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28935", "l": "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = oxaloacetate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49817", "l": "3 [Fe(III)cytochrome c] + H2O + hydrazine => 3 [Fe(II)cytochrome c] + 2 H(+) + NH4(+) + nitric oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65375", "l": "CMP-N-acetyl-beta-neuraminate + globoside GalGb4Cer <=> CMP + globoside MSGG + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36833", "l": "2 caldariellaquinone + n H(+)(out) + 2 H2O => 2 caldariellaquinol + n H(+)(in) + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102886", "l": "alpha-chamigrene synthase activity"}, {"i": "MetaCyc:RXN-8428"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49324", "l": "(5R,6S)-5,6-epoxi-capsanthin = all-trans-capsorubin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676229", "l": "WIPIs bind PI3P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183072", "l": "EGFR non-clathrin mediated endocytosis (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878914", "l": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58008", "l": "(20S)-ginsenoside F1 + UDP-alpha-D-glucose = (20S)-ginsenoside Rg1 + H(+) + UDP"}, {"i": "RHEA:58952", "l": "(20S)-protopanaxatriol + UDP-alpha-D-glucose = (20S)-ginsenoside Rh1 + H(+) + UDP"}, {"i": "EC:2.4.1.366", "l": "\"Ginsenoside F1 6-O-glucosyltransferase\""}, {"i": "EC:2.4.1.367", "l": "\"Ginsenoside 6-O-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52858", "l": "(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56596", "l": "(1S,4S)-bornane-2,5-dione + FMNH2 + O2 = (1S,4S)-5-oxo-1,2-campholide + FMN + H(+) + H2O"}, {"i": "EC:1.14.14.155", "l": "\"3,6-diketocamphane 1,2-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781021", "l": "EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG2 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205262", "l": "Direct recruitment of PI3K to p-KIT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684882", "l": "CHEK1 is recruited to resected DNA DSBs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42085", "l": "9-cis-retinal + H2O + NAD(+) => 9-cis-retinoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72095", "l": "Internal Methylation of mRNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814153", "l": "ADO oxidises 2AET to HTAU (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34550", "l": "ATP + cob(II)yrinate + H2O + L-glutamine <=> ADP + cob(II)yrinate c monoamide + H(+) + L-glutamate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029454", "l": "Autophosphorylation of PAK1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5669012", "l": "EDA binds EDAR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20703", "l": "ATP + lipid A disaccharide (E. coli) <=> ADP + H(+) + lipid IVA (E. coli)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14178", "l": "(R)-amygdalin + H2O => (R)-prunasin + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56775", "l": "2 AH2 + all-trans-adonixanthin + 2 O2 <=> 2 A + all-trans-(3S,3'S)-astaxanthin + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102098", "l": "D-galacturonate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56805", "l": "2 cob(II)yrinate a,c diamide--[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] => 2 cob(I)yrinate a,c diamide--[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17868", "l": "5,6,7,8-tetrahydropteridine + NADP(+) <=> 6,7-dihydropteridine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53386", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADH => 5,10-methylenetetrahydromethanopterin + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011346", "l": "MSI1 binds ROBO3.1 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52267", "l": "3-(aminomethyl)indole + 2 S-adenosyl-L-methionine <=> gramine + 2 H(+) + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66761", "l": "ATP + H2O + kainate(in) => ADP + H(+) + kainate(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404200", "l": "IGF1,2 binds IGF1R (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052630", "l": "UDP-N-acetylgalactosamine diphosphorylase activity"}, {"i": "RHEA:34363", "l": "H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-galactosamine"}, {"i": "EC:2.7.7.83", "l": "\"UDP-N-acetylgalactosamine diphosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866304", "l": "pre-VLDL binds lipids to form VLDL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10488", "l": "5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate"}, {"i": "EC:6.3.3.2", "l": "\"5-formyltetrahydrofolate cyclo-ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009541", "l": "ESR1 binds to TFF1 gene promoter (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48300", "l": "H2O + prostaglandin F2alpha 1-glyceryl ester = glycerol + H(+) + prostaglandin F2alpha"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20838", "l": "all-trans-heptaprenyl diphosphate + diphosphate => all-trans-hexaprenyl diphosphate + isopentenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35194", "l": "noranthrone + O2 <=> H2O + norsolorinic acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61719", "l": "ATP + D-galactofuranose(out) + H2O <=> ADP + D-galactofuranose(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11682", "l": "AMP + diphosphate + GMP + 2 H(+) + L-glutamate => ATP + H2O + L-glutamine + XMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48751", "l": "D-threitol + NAD(+) <=> D-erythrulose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-744231", "l": "SLC35D2 exchanges UDP-sugars for UMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700120", "l": "PTN and MDK bind to PTPRZ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15499", "l": "1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine => 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002953", "l": "5'-deoxynucleotidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036949", "l": "NTRK3 binds GRB2:SOS1 through SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26317", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate = 3-amino-4-hydroxybenzoate + H(+) + 2 H2O + phosphate"}, {"i": "EC:4.1.99.20", "l": "\"3-amino-4-hydroxybenzoate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42172", "l": "(11Z)-eicosenoyl-CoA + AH2 + O2 = (8Z,11Z)-eicosadienoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199839", "l": "AKT can phosphorylate RSK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112385", "l": "Addition of nucleotides leads to transcript elongation (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54507", "l": "all-trans-hexaprenyl diphosphate <=> beta-hexaprene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61403", "l": "ATP + N(6)-(D-ribulosyl)-L-lysine <=> ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9649735", "l": "Intrinsic nucleotide exchange on RAS (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37285", "l": "L-alanine + L-histidine => H2O + L-alanyl-L-histidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38145", "l": "CO2 + 2 H(+) + 2 hydrogen sulfide => carbon disulfide + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997237", "l": "SH2B proteins bind JAK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211191", "l": "Association of DFF with alpha:beta importin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9645598", "l": "RRAGC,D hydrolyzes GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19563", "l": "H2O + NADP(+) + testololactone => androst-4-ene-3,17-dione + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928614", "l": "EFNB:GRB4 binds GIT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6789092", "l": "NOX2 generates superoxide anion from oxygen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2167876", "l": "SMAD7:SMURF2 complex translocates to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72103", "l": "Formation of pre-mRNPs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46562", "l": "2 [Fe(III)-cytochrome b5] + ergosta-5,7,24(28)-trien-3beta-ol + 2 H2O => 2 [Fe(II)-cytochrome b5] + episterol + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16107", "l": "a (2E)-enoyl-CoA + H2O => a (3S)-3-hydroxyacyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810376", "l": "ING2 binds PI5P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381466", "l": "Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60583", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46602", "l": "[HPr protein]-O-phospho-L-serine + ADP + H(+) => [HPr protein]-L-serine + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29389", "l": "CDP + H(+) + phosphate => CTP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29013", "l": "2-oxoglutarate(out) + H(+)(out) => 2-oxoglutarate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29869", "l": "ADP + IDP => AMP + ITP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847880", "l": "CYTH proteins bind ARF1:GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60061", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose => alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395764", "l": "atREs binds to nascent CM (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004148", "l": "dihydrolipoyl dehydrogenase activity"}, {"i": "REACT:R-HSA-1222412", "l": "lpdC dimer reactivates dlaT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201691", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015410", "l": "ABC-type manganese transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15718", "l": "daunorubicin + H(+) + NADPH + O2 => doxorubicin + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047771", "l": "carboxymethylhydantoinase activity"}, {"i": "MetaCyc:CARBOXYMETHYLHYDANTOINASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093332", "l": "p-EPHB phosphorylates SDC2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090560", "l": "2-(3-amino-3-carboxypropyl)histidine synthase activity"}, {"i": "RHEA:36783", "l": "L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine"}, {"i": "EC:2.5.1.108", "l": "\"2-(3-amino-3-carboxypropyl)histidine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38047", "l": "2 [Fe(II)-cytochrome b5] + a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (9Z,12E)-octadecadienoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874082", "l": "MET phosphorylates PTK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38228", "l": "(9Z)-octadecenoyl-CoA + hexadecan-1-ol => CoA + hexadecanyl (9Z)-octadecenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24078", "l": "a 3-oxo-Delta(5)-steroid + H(+) + NADH => a 3beta-hydroxy-Delta(5)-steroid + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59371", "l": "1-octadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphoserine + 10-hydroxyoctadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63847", "l": "[thioredoxin]-dithiol + cumene hydroperoxide <=> 2-phenylpropan-2-ol + [thioredoxin]-disulfide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213195", "l": "Formation of anchoring fibrils (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801184", "l": "TP53 stimulates STEAP3 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098614", "l": "hydrogen selenide methyltransferase activity"}, {"i": "REACT:R-HSA-2408536", "l": "H2Se is methylated to MeSeH by H2Se methyltransferase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25189", "l": "chloroacetate + H2O = chloride + glycolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58695", "l": "FADH2-C4alpha-hydroperoxide + H(+) + NADH + rifamycin SV <=> FADH2 + H2O + NAD(+) + rifamycin SV hemiaminal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202604", "l": "Formation of a heteromeric BMP receptor complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34406", "l": "9-cis-10'-apo-beta-carotenal + 2 O2 <=> (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal + carlactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612255", "l": "ERBB4s80 binds ADAP1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17720", "l": "1D-myo-inositol 1,4,5-trisphosphate + ATP <=> 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63122", "l": "(11Z)-eicosenoate + NH4(+) => (11Z)-eicosenamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72663", "l": "De novo formation of eIF2:GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64128", "l": "H2O + N-octadecanoyl-L-phenylalanine = L-phenylalanine + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42784", "l": "adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.184", "l": "\"23S rRNA (adenine(2085)-N(6))-dimethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40718", "l": "dihydroxyacetone phosphate + hexadecanoyl-CoA <=> 1-hexadecanoylglycerone 3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033486", "l": "Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26447", "l": "3-oxopropanoate + CoA + NADP(+) => H(+) + malonyl-CoA + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21309", "l": "(S)-2,3-epoxysqualene => cycloartenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33830", "l": "ergosterol <=> vitamin D2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55600", "l": "an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose = a mannosylinositol-1-phosphoceramide + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350359", "l": "RHO1:GDP complex dissociates from RHOGDI and binds to the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "71.632434359930443", "identifiers": [{"i": "GO:0043169", "l": "cation binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2203516", "l": "Alpha-1-Microglobulin is cleaved (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-179410", "l": "Association of Nek2A with MCC:APC/C (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030506", "l": "ankyrin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-398040", "l": "Gbeta:gamma activation of PLC beta (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62105", "l": "(9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine => (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63733", "l": "UDP-alpha-D-glucuronate + zolasartan => UDP + zolarsartan O-beta-D-glucuronoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22363", "l": "D-glutamate <=> 5-oxo-D-proline + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693540", "l": "MRN activates ATM (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63315", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> 15-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31481", "l": "H(+) + soyasapogenol A 3-O-beta-D-glucuronate + UDP => soyasapogenol A + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633051", "l": "EFCAB7:IQCE binds EVC2:EVC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31736", "l": "3-oxocholan-24-oyl-CoA + NAD(+) => 3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32186", "l": "cholesterol + O2 <=> cholest-5-en-3-one + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0034594", "l": "phosphatidylinositol trisphosphate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37371", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O = a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.90", "l": "\"Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25248", "l": "(R)-S-lactoylglutathione + H2O <=> (R)-lactate + glutathione + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50419", "l": "L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] <=> H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38909", "l": "(R)-laudanine + H(+) + S-adenosyl-L-homocysteine => (R)-reticuline + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64384", "l": "H2O + N-acetyl-beta-D-6-sulfogalactosaminyl-(1->4)-alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine = alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine + N-acetyl-D-6-sulfogalactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668335", "l": "CHMP7 binds LEMD2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20697", "l": "2 H(+) + 2 superoxide => H2O2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032327", "l": "5-oxo-EPA, 15d-PGJ3 translocate from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017045", "l": "corticotropin-releasing hormone activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168445", "l": "PTP1B binds the GH receptor complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56388", "l": "(5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 = (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602672", "l": "Defective IRAK4 does not bind MyD88 within the TLR2/4 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193686", "l": "p75NTR interacts with IRAK:MYD88 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009208", "l": "Activated ERKs phosphorylate RUNX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40016", "l": "(+)-copalyl diphosphate + H2O => 13-epi-manool + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110307", "l": "REV1 binds AP-dsDNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52618", "l": "3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-threonyl-[protein] + ADP + H(+) => 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5591086", "l": "SERPINA5 binds activated protein C (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.107", "l": "\"Sanguinarine reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265887", "l": "Binding of RPA heterotrimer to 3' double stranded DNA break (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200879", "l": "Formation of a Nef:ARF1:CD4 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420206", "l": "Phosphorylation of SRC-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15182", "l": "an acyl-CoA(out) + ATP + H2O => ADP + an acyl-CoA(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191303", "l": "FDPS dimer transfers IPPP to GPP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418868", "l": "Recruitment of Src and Fyn to DCC:FADK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25469", "l": "(2E,6E)-farnesyl diphosphate => beta-himachalene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016205", "l": "selenocysteine methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866277", "l": "AP-2 directly binds some endocytic cargo (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619756", "l": "NR1H2 binds ABCA1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694506", "l": "Synthesis of SARS-CoV-2 plus strand subgenomic mRNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182795", "l": "RNase H-mediated degradation of the template strand (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58929", "l": "(3R,4R)-7,2',4'-trihydroxyisoflavanol => (6aR,11aR)-3,9-dihydroxypterocarpan + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19024", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine <=> an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39574", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61105", "l": "(2S)-naringenin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (2S)-dihydrotricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174070", "l": "Association of Cdh1 with the APC/C (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48074", "l": "ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate => ganglioside GM1 (d18:1(4E)) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54790", "l": "[LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide => [LarE protein]-L-cysteine + ATP + pyridinium-3,5-dicarboxylate mononucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109701", "l": "PDPK1 binds PIP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37962", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> (13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14916", "l": "AMP + thymidine <=> adenosine + dTMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63849", "l": "2 2',3,4-trihydroxy-trans-chalcone + 2 H(+) + O2 => 2 3',4'-dihydroxyaurone + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46522", "l": "2 [Fe(III)-cytochrome b5] + an N-(2R-hydroxyacyl)-4R-hydroxysphinganine + H2O => 2 [Fe(II)-cytochrome b5] + an N-(1,2 saturated acyl)-(4R)-hydroxysphinganine + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391936", "l": "EP1 receptor can bind PGE2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047218", "l": "hydroxycinnamate 4-beta-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213192", "l": "Hemidesmosome formation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27705", "l": "aldehydo-D-galacturonate <=> keto-D-tagaturonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66778", "l": "ADP + H(+) + phosphate + uroporphyrin III(out) => ATP + H2O + uroporphyrin III(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418856", "l": "Activation of Rac1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25286", "l": "lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655483", "l": "USP1 autocleavage (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5635854", "l": "GLI2,3 are degraded by the proteasome (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782893", "l": "TRMT12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109858", "l": "MAP2K2 binds MAPK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60671", "l": "(R,R)-chrysanthemol + NAD(+) <=> (1R,3R)-chrysanthemal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783670", "l": "CRLF1 binds CLCF1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9715356", "l": "brigatinib-resistant ALK mutants don't bind brigatinib (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11729", "l": "cyclopentanol + NAD(+) => cyclopentanone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852010", "l": "BTNL2 binds activated T cells surface (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29141", "l": "2 H(+)(out) + H2O + menaquinone-8 + nitrite => 2 H(+)(in) + menaquinol-8 + nitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44592", "l": "3-(all-trans-heptaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-heptaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19183", "l": "a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a very-long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11097", "l": "NADP(+) + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656213", "l": "RAF1 mutants show enhanced heterodimerization with BRAF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047282", "l": "dTDP-dihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12324", "l": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine = L-asparagine + N-acetyl-D-glucosamine"}, {"i": "EC:3.2.2.11", "l": "\"Beta-aspartyl-N-acetylglucosaminidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17951", "l": "CO + H(+) + N-formylanthranilate => 3-hydroxy-1H-quinolin-4-one + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52048", "l": "9-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 9-hydroxy-octadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12220", "l": "H2O + L-leucine + NAD(+) = 4-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)"}, {"i": "EC:1.4.1.9", "l": "\"Leucine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55231", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50677", "l": "H(+) + H2O + N-terminal L-asparaginyl-[protein] => N-terminal L-aspartyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000120", "l": "CBLIF binds Cbl (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62525", "l": "cytidine(839) in 12S rRNA + S-adenosyl-L-methionine => H(+) + N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-874087", "l": "SGT1 binds HSP90 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432129", "l": "FGR binds and phosphorylates LRP8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52138", "l": "GMP + 2 H(+) + phospho-5'-(DNA) => guanosine-5'-diphospho-5'-(DNA) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33965", "l": "ADP + isopentenyl diphosphate => ATP + isopentenyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427528", "l": "Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18883", "l": "ADP + H(+) + N(alpha)-gamma-L-glutamylhistamine + phosphate => ATP + histamine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696357", "l": "LAIR2 binds collagen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.203", "l": "\"Carboxymethylcellulase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917839", "l": "apo-Transferrin dissociates from the receptor complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21876", "l": "(6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) = (S)-usnate + 2 H(+) + NADH"}, {"i": "EC:1.1.1.199", "l": "\"(S)-usnate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64250", "l": "CoA + H(+) + N-decanoylglycine => decanoyl-CoA + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21600", "l": "anthranilate + benzoyl-CoA = CoA + N-benzoylanthranilate"}, {"i": "EC:2.3.1.144", "l": "\"Anthranilate N-benzoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10841", "l": "H2O + O-phospho-L-homoserine => L-threonine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865275", "l": "PDGF-BB clevage by Furin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045545", "l": "syndecan binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26132", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42808", "l": "2 H(+) + 3 H2O + hydrogen sulfide + 3 oxidized coenzyme F420-(gamma-Glu)(n) = 3 reduced coenzyme F420-(gamma-Glu)(n) + sulfite"}, {"i": "EC:1.8.98.3", "l": "\"Sulfite reductase (coenzyme F420)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786421", "l": "CHIA hydrolyses chitin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785244", "l": "Defective CYP11B2 does not oxidise 18HCORST (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55853", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA => [(2->6)-alpha-D-glucosyl-(1->4)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50569", "l": "acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33663", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine + O2 = 2 [Fe(III)-cytochrome b5] + H2O + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18447", "l": "5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide => H2O + IMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.n1", "l": "\"Blood group B branched chain alpha-1,3-galactosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21742", "l": "[thioredoxin]-disulfide + H(+) + hydrogen sulfide + pyruvate => 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205649", "l": "p62 links damaged mitochondria to LC3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427570", "l": "Group 3 - Selective Cl- transport (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15145", "l": "D-maltose = alpha,alpha-trehalose"}, {"i": "EC:5.4.99.16", "l": "\"Maltose alpha-D-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57995", "l": "(20S)-ginsenoside C-K + UDP-alpha-D-glucose <=> (20S)-ginsenoside F2 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19725", "l": "H(+) + UDP-alpha-D-galacturonate = CO2 + UDP-beta-L-arabinopyranose"}, {"i": "EC:4.1.1.67", "l": "\"UDP-galacturonate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34100", "l": "carboxynorspermidine + H(+) => CO2 + norspermidine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090422", "l": "thiamine pyrophosphate transmembrane transporter activity"}, {"i": "REACT:R-HSA-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0008875", "l": "gluconate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40539", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.15.33", "l": "\"Pikromycin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55996", "l": "H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] = beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29865", "l": "ADP + GDP => AMP + GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36150", "l": "acetyl-CoA + benzyl alcohol <=> benzyl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0031795", "l": "G protein-coupled GABA receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661217", "l": "MT1A binds zinc (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45381", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + (5Z,8Z,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60369", "l": "urate(out) => urate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111930", "l": "Adenylate cyclase produces cAMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11527", "l": "5beta-cholestan-3-one + NADP(+) <=> cholest-4-en-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805122", "l": "AURKB binds TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-532549", "l": "MPI isomerises Fru6P to Man6P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2032775", "l": "YAP1 binds TEAD1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30246", "l": "4 L-ascorbate + O2 <=> 2 H2O + 4 monodehydro-L-ascorbate radical"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47464", "l": "(3E,5Z)-tetradecadienoyl-CoA = (2E,5Z)-tetradecadienoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64850", "l": "(3Z)-hex-3-en-1-yl benzoate + CoA => (3Z)-hex-3-en-1-ol + benzoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48146", "l": "ganglioside GT1b (d18:1(4E)/18:0) + N-acetylneuraminate => H2O + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-(octadecanoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692779", "l": "p-S182 MAPKAPK5 phosphorylates FOXO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442749", "l": "CaMKK autophosphorylates in the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25859", "l": "(9Z)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18487", "l": "acetate + D-glucose + H(+) => 6-acetyl-D-glucose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985275", "l": "RUNX2 binds to SATB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12776", "l": "2-oxoglutarate + O2 + proclavaminate <=> CO2 + dihydroclavaminate + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51686", "l": "(2E,6E)-farnesyl diphosphate + CDP => (2E,6E)-farnesyl phosphate + CTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29040", "l": "ATP + H2O + L-aspartate(out) => ADP + H(+) + L-aspartate(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26255", "l": "2 H2O + isopimara-7,15-dienal + NADP(+) => H(+) + isopimara-7,15-dienol + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168184", "l": "Activated TAK1 mediates phosphorylation of the IKK Complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44779", "l": "2-demethylmenaquinol-6 + S-adenosyl-L-methionine <=> H(+) + menaquinol-6 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29525", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+) => alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932322", "l": "CK2 phosphorylates NFE2L2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.17"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140566", "l": "epigenetic reader"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36672", "l": "(17Z)-hexacosenoyl-CoA + sphinganine => CoA + H(+) + N-[(17Z)-hexacosenoyl]dihydrosphingosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21339", "l": "NAD(+) + pyridoxal <=> 4-pyridoxolactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912291", "l": "Incorrectly folded glycoproteins translocate to the ERQC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12778", "l": "2-amino-4-hydroxypteridine + O2 => 2-amino-4,7-dihydroxypteridine + chemical entity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51746", "l": "a 1,2-diacyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50895", "l": "a menaquinone + 2 H(+) + hydrogen sulfide + sulfite <=> a menaquinol + thiosulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404193", "l": "IGF1R phosphorylates SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684836", "l": "CLEC1B dimer binds PDPN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15729", "l": "D-mannonate + NAD(+) = H(+) + keto-D-fructuronate + NADH"}, {"i": "RHEA:51652", "l": "D-mannonate + NAD(+) = H(+) + keto-D-tagaturonate + NADH"}, {"i": "EC:1.1.1.57", "l": "\"Fructuronate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63741", "l": "2-phenylacetaldehyde + H(+) + NADH => 2-phenylethanol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684267", "l": "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46221", "l": "androst-5-en-3beta,17beta-diol + NAD(+) => 3beta-hydroxyandrost-5-en-17-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39283", "l": "a long-chain fatty acid(out) = a long-chain fatty acid(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23220", "l": "4-chlorobenzoate + ATP + CoA = 4-chlorobenzoyl-CoA + AMP + diphosphate"}, {"i": "EC:6.2.1.33", "l": "\"4-chlorobenzoate--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-706479", "l": "TAK1 is activated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205238", "l": "SHP2 interacts with p-KIT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12405", "l": "D-glucose + UDP-alpha-D-galactose => H(+) + lactose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41852", "l": "H(+) + malonyl-[ACP] + octanoyl-[ACP] = 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2219524", "l": "PDPK1 binds PIP2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21325", "l": "2 H(+) + reduced [rubredoxin] + superoxide => H2O2 + oxidized [rubredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429101", "l": "HMIT co-transports myo-inositol with a proton (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18308", "l": "acetyl-CoA + N-acetylneuraminate <=> CoA + N-acetyl-4-O-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22843", "l": "D-glutamine + H2O <=> D-glutamate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13364", "l": "CTP + H(+) + sn-glycerol 3-phosphate <=> CDP-glycerol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27923", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O + O2 => 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102069", "l": "zerumbone synthase activity"}, {"i": "RHEA:32327", "l": "10-hydroxy-alpha-humulene + NAD(+) = H(+) + NADH + zerumbone"}, {"i": "EC:1.1.1.326", "l": "\"Zerumbone synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018448", "l": "hydroxymethylmethylsilanediol oxidase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "61.174745187870577", "identifiers": [{"i": "GO:0046873", "l": "metal ion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4084507", "l": "Laminin-111 binds endostatin dimer (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50180", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.15", "l": "\"(Kdo)(3)-lipid IV(A) (2-4) 3-deoxy-D-manno-octulosonic acid transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45677", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015054", "l": "gastrin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12474", "l": "ethylamine + glyoxylate + H2O2 => H2O + N-ethylglycine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57840", "l": "1D-myo-inositol 1,3-bisphosphate + H2O = 1D-myo-inositol 1-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63006", "l": "(11Z,14Z)-eicosadienoate + NH4(+) => (11Z,14Z)-eicosadienamide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0043998", "l": "H2A histone acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63312", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 = 15-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25471", "l": "(2E,6E)-farnesyl diphosphate <=> beta-himachalene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6793666", "l": "MDM2 translocates to the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10061", "l": "acetyl-CoA + D-tryptophan => CoA + H(+) + N-acetyl-D-tryptophan"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031865", "l": "EP2 subtype prostaglandin E2 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35952", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate => diphosphate + N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42267", "l": "H(+) + malonyl-[ACP] + octanoyl-CoA <=> 3-oxodecanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20196", "l": "(R)-mevalonate + NADP(+) <=> H(+) + mevaldate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20557", "l": "2 H(+) + H2O + urea = CO2 + 2 NH4(+)"}, {"i": "EC:3.5.1.5", "l": "\"Urease\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878117", "l": "RUNX3 binds ZFHX3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55812", "l": "a bacteriochlorophyllide d + H2O + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + a bacteriochlorophyllide f + 2 H(+) + 2 L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810894", "l": "Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018604", "l": "4-aminobenzoate 3,4-dioxygenase (deaminating) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46542", "l": "2 [Fe(III)-cytochrome b5] + a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-containing glycerolipid + 2 H2O => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43821", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004767", "l": "sphingomyelin phosphodiesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180736", "l": "Disassembly of the Rev-importin beta-B23:Ran-GTP complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48837", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295622", "l": "SPRY2 binds CBL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53210", "l": "2'-hydroxydaidzein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => daidzein + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264848", "l": "apoA-I binds to CUBN:AMN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19672", "l": "GTP + H2O <=> GDP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32001", "l": "bicyclogermacrene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57508", "l": "H2O + NADP(+) + staphylopine = (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate"}, {"i": "EC:1.5.1.52", "l": "\"Staphylopine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10767", "l": "(2R,3S,4S)-leucocyanidin + 2-oxoglutarate + O2 <=> (4S)-2,3-dehydroleucocyanidin + CO2 + H(+) + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64580", "l": "(2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + nerylneryl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695415", "l": "glycosylated-ACE2 binds ACE2 inhibitors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855111", "l": "VLDLR binds PCSK9 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.13", "l": "\"N(1)-acetylpolyamine oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023173", "l": "Insulin secretory granule docks at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.36"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196753", "l": "2xPPCS ligates PPanK with Cys (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51599", "l": "2 H(+) + O2 + p-xylene + 2 reduced [2Fe-2S]-[ferredoxin] <=> 4-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47023", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O <=> [DsrC protein]-disulfide + 3 AH2 + 2 H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592362", "l": "Activation of proMMP7 by MMP3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54607", "l": "2-oxoglutarate + decanoyl-CoA + O2 <=> 2-hydroxydecanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050447", "l": "zeatin 9-aminocarboxyethyltransferase activity"}, {"i": "KEGG.REACTION:R03133"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16932", "l": "2 benzoyl-CoA + L-ornithine <=> 2 CoA + 2 H(+) + N(2),N(5)-dibenzoyl-L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975594", "l": "PLB1 hydrolyses RPALM to atROL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49979", "l": "butanoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + butanoyl-4'-phosphopantetheine + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31113", "l": "3-oxohexanoyl-CoA + CoA => acetyl-CoA + butanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28900", "l": "glycine(in) + H(+)(in) => glycine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23516", "l": "(R)-glycerate + ATP = (2R)-3-phosphoglycerate + ADP + H(+)"}, {"i": "EC:2.7.1.31", "l": "\"Glycerate 3-kinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008114", "l": "phosphogluconate 2-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28425", "l": "(1E,2S)-2-methylbutanal oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2-methylbutanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030739", "l": "O-demethylpuromycin O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34724", "l": "15-methylhexadecasphing-4-enine 1-phosphate + H2O => 15-methylhexadecasphing-4-enine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.116", "l": "\"D-ornithine/D-lysine decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102874", "l": "1-16:0-2-18:2-digalactosyldiacylglycerol desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60935", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 17-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928631", "l": "GIT1 binds bPIX (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59060", "l": "(20S)-ginsenoside Rg3 + H2O = (20S)-ginsenoside Rh2 + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53187", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O <=> 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17843", "l": "H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP => trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60731", "l": "citral + H2O + NADP(+) <=> 3,7-dimethylocta-2,6-dienoate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047397", "l": "dolichylphosphate-glucose phosphodiesterase activity"}, {"i": "RHEA:13857", "l": "dolichyl beta-D-glucosyl phosphate + H2O = D-glucose + dolichyl phosphate + H(+)"}, {"i": "EC:3.1.4.48", "l": "\"Dolichylphosphate-glucose phosphodiesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14573", "l": "D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O"}, {"i": "EC:4.2.1.40", "l": "\"Glucarate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5333051", "l": "RPA1 binds HSF1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196929", "l": "FLAD1 phosphorylates FMN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33760", "l": "a 3-oxo-fatty acyl-CoA + H(+) + NADPH => a 3-hydroxy-fatty acyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62288", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate = (S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66313", "l": "an alpha-mannosylinositol-1-phosphoceramide + H2O => a D-mannosyl-alpha-1->6-inositol-1-phosphate + an N-acyl-sphingoid base + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204485", "l": "Basigin binds CyPA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16022", "l": "oxaloacetate => enol-oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-445079", "l": "Phosphorylation of L1 by ERK (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682377", "l": "LC3 de-lipidation by ATG4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18384", "l": "dihydroxyacetone + phosphoenolpyruvate <=> dihydroxyacetone phosphate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6790454", "l": "SUMOylation of XPC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51890", "l": "2,3,5,6-tetrachloro-1,4-benzoquinone + NADH => 2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45997", "l": "a D-alpha-amino acid + a quinone + H2O => a 2-oxocarboxylate + a quinol + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627369", "l": "SEPT4 binds XIAP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51224", "l": "2 [Fe(III)cytochrome c] + S-sulfanyl-L-cysteinyl-[SoxY protein] + thiosulfate = 2 [Fe(II)cytochrome c] + 2 H(+) + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein]"}, {"i": "RHEA:56720", "l": "2 [Fe(III)cytochrome c] + L-cysteinyl-[SoxY protein] + thiosulfate = 2 [Fe(II)cytochrome c] + 2 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]"}, {"i": "EC:2.8.5.2", "l": "\"L-cysteine S-thiosulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11371", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H(+) + NADH + O2 <=> 1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814094", "l": "ARL1:GTP binds ARFIP2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647980", "l": "mature RAS proteins translocate to plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2248891", "l": "Active ARSA translocates to the lysosome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1250264", "l": "TXNIP binds reduced thioredoxin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097160", "l": "polychlorinated biphenyl binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66995", "l": "3-methylpentanoate + ATP + CoA <=> 3-methylpentanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358798", "l": "RNF41 binds neuregulin-activated ERBB3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112392", "l": "Resumption of elongation after recovery from pausing (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210285", "l": "Trans-homophilic interaction of PECAM-1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20254", "l": "(2R,3S)-2,3-dimethylmalate => dimethylmaleate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23907", "l": "an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] <=> 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51539", "l": "L-tyrosyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-L-tyrosyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24198", "l": "(2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+) => (2R,4S)-2,4-diaminopentanoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29229", "l": "H(+)(out) + indole(out) => H(+)(in) + indole(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39923", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.-", "l": "\"Other carbon-carbon lyases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139893", "l": "Granzyme-B activates BID by cleavage (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70613", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003944", "l": "N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381537", "l": "PAPP-A2 proteolyzes IGF:IGFBP5:ALS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419166", "l": "GEFs activate RhoA,B,C (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853745", "l": "RET binds GFRA1,GFRA3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0051400", "l": "BH domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.8", "l": "\"Delta(3)-Delta(2)-enoyl-CoA isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61510", "l": "peonidin 3-O-beta-D-glucoside + UDP => peonidin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.14", "l": "\"Chlorophyllase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004689", "l": "phosphorylase kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40805", "l": "3,6-anhydro-L-galactonate + 2 H(+) + NADPH => 3,6-anhydro-alpha-L-galactopyranose + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34505", "l": "(+)-epi-alpha-bisabolol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24239", "l": "2 [Fe(III)cytochrome c] + H2O + trimethylamine <=> 2 [Fe(II)cytochrome c] + 3 H(+) + trimethylamine N-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380780", "l": "Activation of Src (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9005980", "l": "IL21 binds IL21R:JAK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1912357", "l": "ITCH ubiquitinates DTX (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39823", "l": "2 [Fe(II)-cytochrome b5] + eicosanoate + 2 H(+) + O2 = 2-hydroxyeicosanoate + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047230", "l": "flavonol-3-O-glucoside L-rhamnosyltransferase activity"}, {"i": "RHEA:22528", "l": "a flavonol 3-O-beta-D-glucoside + UDP-beta-L-rhamnose = a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + H(+) + UDP"}, {"i": "EC:2.4.1.159", "l": "\"Flavonol-3-O-glucoside L-rhamnosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42841", "l": "acetyl-CoA + 6 H(+) + 5 malonyl-CoA + 2 NADPH => 2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 3 H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004136", "l": "deoxyadenosine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204861", "l": "Interaction of Tie2 and Shc1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008814", "l": "citrate CoA-transferase activity"}, {"i": "RHEA:19405", "l": "acetyl-CoA + citrate = (3S)-citryl-CoA + acetate"}, {"i": "EC:2.8.3.10", "l": "\"Citrate CoA-transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20272", "l": "4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate <=> 2 5-dehydro-4-deoxy-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592245", "l": "NRF1:PPARGC1B binds the ALAS1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374173", "l": "AGT(34-41) binds to AGTR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621606", "l": "CD209 binds ManLAM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943279", "l": "GGT dimers hydrolyse GSH (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9640195", "l": "RRAGA,B hydrolyzes GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682388", "l": "Autophagosome maturation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35946", "l": "brevianamide F + dimethylallyl diphosphate <=> deoxybrevianamide E + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75850", "l": "Addition of the third nucleotide on the nascent transcript (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671737", "l": "p-T774-PKN1 binds CDC25C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5695964", "l": "ABHD14B hydrolyses PNPB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72647", "l": "Cap-bound mRNA is activated by helicases  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15544", "l": "DIMBOA + UDP-alpha-D-glucose <=> DIMBOA beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901039", "l": "MAN1B1 hydrolyses 1,2-linked mannose (c branch) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31512", "l": "chenodeoxycholoyl-CoA + H2O => chenodeoxycholate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63946", "l": "an N-acyl-sphinga-4E,14Z-dienine + CoA + H(+) => a fatty acyl-CoA + sphinga-4E,14Z-dienine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158832", "l": "The acetyl group from acetyl-CoA is transferred to the NAT2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416562", "l": "p190RhoGAP binds Plexin-B1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050503", "l": "trehalose 6-phosphate phosphorylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48283", "l": "ganglioside GM2 + UDP-alpha-D-galactose <=> ganglioside GM1 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52462", "l": "17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 17beta-estradiol + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168884", "l": "Hemagglutinin (HA) protein synthesis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35701", "l": "(2S-3S)-versiconal hemiacetal + H(+) + NADPH => (S)-versiconol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43452", "l": "2 H(+) + hexanoyl-CoA + 2 malonyl-CoA = 4-hydroxy-6-pentylpyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15084", "l": "acetate + ATP + CoA <=> acetyl-CoA + ADP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40884", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + FAD + H(+) => (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944454", "l": "mTORC1 phosphorylates MAF1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483174", "l": "PE is methylated to PC by PEMT (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66725", "l": "(S)-lactate + L-phenylalanine => H2O + N-[(S)-lactoyl]-L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042944", "l": "D-alanine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18794", "l": "alpha-D-ribose 1-phosphate => D-ribose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45698", "l": "N-(acetyl)-sphing-4-enine-1-phosphate(out) => N-(acetyl)-sphing-4-enine-1-phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51217", "l": "3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one => 3beta-sulfooxy-androst-5-en-17-one + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084912", "l": "Arresten binds integrin alpha1beta1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428273", "l": "SPHK1 phosphorylates SPG to S1P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140842", "l": "n fibrin monomers -> fibrin multimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55555", "l": "N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033447", "l": "AGA codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39162", "l": "(3R)-hydroxyhexadecanoyl-CoA <=> (2E)-hexadecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801415", "l": "TP53 stimulates NLRC4 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672948", "l": "MARK3 phosphorylates KSR1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9696271", "l": "RND1 binds effectors (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2203479", "l": "STAB2 (FEEL-2) binds ligands (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32472", "l": "demethylsuberosin + O2 + reduced [NADPH--hemoprotein reductase] => (7S)-marmesin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37458", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2172678", "l": "PHF8 demethylates histone H4K20me1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592297", "l": "Full activation of MMP1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617650", "l": "HOXD3 chromatin is activated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25943", "l": "8-chloroquinoline + A + H2O <=> 8-chloroquinolin-2(1H)-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54157", "l": "2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2 => [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52015", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA <=> 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46308", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 17alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692941", "l": "BACE1:GGA1,2,3 translocates from plasma membrane to endosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47239", "l": "eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353044", "l": "2-phosphoglycerate <=> phosphoenolpyruvate + H2O (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35963", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin A = fumitremorgin C + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.19.71", "l": "\"Fumitremorgin C synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854209", "l": "TBC1D10A binds JFC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56354", "l": "3-bromo-4-hydroxybenzoate + 2 H2O + NADP(+) => 4-hydroxybenzoate + bromide + 2 H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12982", "l": "H2O + O2 + S-sulfanylglutathione => glutathione + 2 H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034015", "l": "L-ribulose-5-phosphate 3-epimerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168635", "l": "PRKCB (PKC-beta) phosphorylates CARMA1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31590", "l": "FMNH2 + NADH + O2 + uracil <=> (Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57465", "l": "(E)-caffeate + UDP-alpha-D-glucose => 1-O-[(E)-caffeoyl]-beta-D-glucose + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218815", "l": "p-6Y-VEGFR2 binds NCK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25754", "l": "N-hydroxy-L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46112", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635936", "l": "ATF4 binds the CEBPB gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8858428", "l": "FCAMR binds IgA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45842", "l": "3-oxodecanoyl-CoA + H(+) + NADPH => (3R)-3-hydroxydecanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24767", "l": "UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate <=> UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43460", "l": "dodecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-undecylpyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191303", "l": "FDPS dimer transfers IPPP to GPP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30457", "l": "(-)-geosmin => (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166091", "l": "IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160915", "l": "Receptor-mediated uptake of HA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047180", "l": "salutaridinol 7-O-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684887", "l": "Activation of CHEK1 at resected DNA DSBs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15425", "l": "coproporphyrinogen III + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX"}, {"i": "EC:1.3.98.3", "l": "\"Coproporphyrinogen dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19150", "l": "L-arginyl-[protein] + NAD(+) => H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380586", "l": "loading of Serotonin in synaptic vesicles (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38667", "l": "sphing-4-enine 1-phosphate(in) = sphing-4-enine 1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5679266", "l": "Beclin-1 complex translocates to the ER (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420131", "l": "The PACAP receptor binds PACAP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43168", "l": "adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)"}, {"i": "EC:3.5.4.33", "l": "\"tRNA(adenine(34)) deaminase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050286", "l": "sorbitol-6-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30351", "l": "H(+) + NADH + O2 + pyrrole-2-carboxylate = 5-hydroxypyrrole-2-carboxylate + H2O + NAD(+)"}, {"i": "EC:1.14.13.130", "l": "\"Pyrrole-2-carboxylate monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61195", "l": "(E)-4-coumaroyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] <=> CoA + H(+) + myricetin 3-O-[(6-O-(E)-4-coumaroyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50220", "l": "(S)-demethyl-4-deoxygadusol = (R)-demethyl-4-deoxygadusol"}]}
{"type": "biolink:MolecularActivity", "ic": "81.790986234327661", "identifiers": [{"i": "GO:0016884", "l": "carbon-nitrogen ligase activity, with glutamine as amido-N-donor"}, {"i": "EC:6.3.5.-", "l": "\"Carbon--nitrogen ligases with glutamine as amido-N-donor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163666", "l": "Formation of ChREBP:MLX heterodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48937", "l": "2-oxoglutarate + L-prolyl-[Skp1 protein] + O2 => CO2 + succinate + trans-4-hydroxy-L-prolyl-[Skp1 protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169307", "l": "Monoubiquitination of N-myristoyl GAG (P12493) protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9724685", "l": "IgE binds omalizumab (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28887", "l": "H(+)(in) + L-serine(in) = H(+)(out) + L-serine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61077", "l": "(-)-minovincinine + acetyl-CoA => (-)-echitovenine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047506", "l": "(deoxy)adenylate kinase activity"}, {"i": "MetaCyc:DEOXYADENYLATE-KINASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20387", "l": "(2R,3R)-2,3-dihydrogossypetin + H2O + NAD(+) => (2R,3R)-dihydroquercetin + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4647593", "l": "EP400 binds CDKN1A promoter (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8863727", "l": "STON2 is neddylated (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35354", "l": "NADP(+) + octadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31786", "l": "H2O + tuberculosinyl diphosphate <=> diphosphate + tuberculosinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29212", "l": "H(+)(out) + inosine(in) => H(+)(in) + inosine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534378", "l": "Hv1 Mediated H+ Permeability (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10385", "l": "cyclo-acetoacetyl-L-tryptophan + dimethylallyl diphosphate => beta-cyclopiazonate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043472", "l": "IgD binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55927", "l": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] <=> albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49537", "l": "2-amino-2-deoxy-D-gluconate => (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-844438", "l": "NLRP1 oligomerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17472", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester + apo--[retinol-binding protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784765", "l": "p-Y705-STAT3 dimerizes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44969", "l": "(2E)-tetradecenoyl-CoA + H(+) + NADPH => NADP(+) + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75850", "l": "Addition of the third nucleotide on the nascent transcript (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14665", "l": "guanine + H(+) + H2O = NH4(+) + xanthine"}, {"i": "EC:3.5.4.3", "l": "\"Guanine deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22500", "l": "(E)-feruloyl-CoA + H(+) + malonyl-CoA = (E)-feruloylacetyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685230", "l": "CHEK1 phosphorylates RAD51 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50520", "l": "acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64600", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76416", "l": "Benzene is hydroxylated to phenol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45245", "l": "(3E,5Z)-octadienoyl-CoA => (2E,4E)-octadienoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65277", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 2alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641206", "l": "RSPOs bind LGRs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448702", "l": "Caspase-1 active tetramer formation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59377", "l": "4-amino-4-deoxychorismate => 4-amino-4-deoxyprephenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183055", "l": "Binding of CBL to EGFR (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22216", "l": "(E)-caffeate + O2 = 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+)"}, {"i": "EC:1.13.11.22", "l": "\"Caffeate 3,4-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65269", "l": "3-hydroxypentacecilide A + H(+) + NADPH + O2 => chrodrimanin F + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33396", "l": "H2O + N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester => GMP + N(alpha)-acetyl-L-lysine methyl ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-606326", "l": "HJURP:CENPA complex localizes to the centromere (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380930", "l": "Phosphorylated AMPK binds AMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26038", "l": "2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3,8'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57883", "l": "3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-alpha-D-xylose <=> 3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49316", "l": "beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (5R,6S)-5,6-epoxi-beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59941", "l": "2-methyloctadecanoyl-CoA + H2O => 2-methyloctadecanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193646", "l": "NGF binding to p75NTR inactivates RHOA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350869", "l": "Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36305", "l": "a long-chain primary fatty alcohol + CoA + 2 NADP(+) => a fatty acyl-CoA + 2 H(+) + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933258", "l": "LSR trimer binds LDL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24828", "l": "dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388828", "l": "PD-1 binds B7DC and B7H1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57409", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + NAD(+) => 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5632652", "l": "Hh-Npp binds CDON and PTCH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36158", "l": "AH2 + Co(II)-factor III + S-adenosyl-L-methionine <=> A + Co-precorrin-4 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32402", "l": "(1S,2R,4S)-neodihydrocarveol + NAD(+) <=> (1S,4S)-dihydrocarvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000399", "l": "RANBP2 SUMOylates SP100 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23167", "l": "a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose <=> a flavonol 7-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166817", "l": "Cleavage of C3 by C3 convertases (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627107", "l": "XIAP binds CASP7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3244643", "l": "STING binds cyclic GMP-AMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46762", "l": "4-methyl-5-nitrocatechol + NAD(+) + nitrite => 2,4-dinitrotoluene + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357828", "l": "RIPK1 is cleaved by CASP8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30824", "l": "UDP-N-acetyl-alpha-D-glucosamine => H2O + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32097", "l": "CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H(+) => acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58440", "l": "N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37563", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21426", "l": "3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH => 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389964", "l": "Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E+ Cofactor C-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018798", "l": "RHOV binds GTP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44068", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006992", "l": "MECP2 is phosphorylated at S423 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334052", "l": "TFC7L2 mutants don't bind CTBP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1008200", "l": "NFE2 binds the beta globin locus control region (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13891", "l": "AMP + FMN + 2 H(+) => FAD + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21342", "l": "2 vanillin => 1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58049", "l": "2-O-sulfo-alpha,alpha-trehalose + octadecanoyl-CoA => 2-O-sulfo-2'-O-octadecanoyl-alpha,alpha-trehalose + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43708", "l": "ATP + H(+) + hexadecanoate = diphosphate + hexadecanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22807", "l": "(6S,9R)-vomifoliol + NAD(+) <=> (6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36060", "l": "A + dihydrourocanate => AH2 + urocanate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44807", "l": "1,4-dihydroxy-2-naphthoate + all-trans-nonaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-9 + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174959", "l": "The acetyl group from acetyl-CoA is transferred to the NAT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694592", "l": "3CLp dimer binds 3CLp inhibitors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35986", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15296", "l": "arsenite + S-adenosyl-L-methionine <=> H(+) + methylarsonate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376419", "l": "Formation of NR-MED1 Coactivator Complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190261", "l": "FGFR3c binds to FGF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23001", "l": "(R)-pantoate + NAD(+) => (R)-4-dehydropantoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4615910", "l": "SUMOylation of PCNA with SUMO1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-383190", "l": "HCO3- transport through ion channel (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2106586", "l": "WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166015", "l": "Association of LBP with LPS (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9613497", "l": "Unwinding DNA for the nascent transcript (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5622134", "l": "CRABP1 binds atRA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45373", "l": "H2O + N-(9Z-octadecenoyl)-sphinganine => (9Z)-octadecenoate + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12101", "l": "1,5-anhydro-D-fructose => H2O + microthecin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46708", "l": "2-hydroxybenzoyl-5'-AMP + holo-[non-ribosomal peptide synthase] = AMP + H(+) + salicyl-[non-ribosomal peptide synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139899", "l": "Sequestration of BAD protein by 14-3-3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42892", "l": "5'-deoxyadenosine + H(+) + H2O = 5'-deoxyinosine + NH4(+)"}, {"i": "EC:3.5.4.41", "l": "\"5'-deoxyadenosine deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3782535", "l": "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606583", "l": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52636", "l": "2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2 = a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate"}, {"i": "EC:1.14.11.n2", "l": "\"Methylcytosine dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21972", "l": "precorrin-1 + S-adenosyl-L-methionine = precorrin-2 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050549", "l": "cyclohexyl-isocyanide hydratase activity"}, {"i": "RHEA:18197", "l": "H(+) + N-cyclohexylformamide = cyclohexyl isocyanide + H2O"}, {"i": "EC:4.2.1.103", "l": "\"Cyclohexyl-isocyanide hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852010", "l": "BTNL2 binds activated T cells surface (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31007", "l": "(S)-2,3-epoxysqualene = beta-amyrin"}, {"i": "EC:5.4.99.39", "l": "\"Beta-amyrin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52274", "l": "gramine + H(+) + S-adenosyl-L-homocysteine => (1H-indol-3-yl)-N-methylmethanamine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50415", "l": "L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein] <=> H(+) + N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36734", "l": "1-nitrocyclohexan + NADP(+) <=> 1-nitrocyclohexene + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13601", "l": "4-hydroxy-L-proline + NAD(+) = 4-oxo-L-proline + H(+) + NADH"}, {"i": "EC:1.1.1.104", "l": "\"4-oxoproline reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10451", "l": "2-oxoglutarate + a flavanone + O2 <=> a flavone + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113429", "l": "Elongating transcript encounters a lesion in the template (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42143", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-(4R)-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24694", "l": "acetate + NADP(+) + trans-isoeugenol = (E)-coniferyl acetate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380222", "l": "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685318", "l": "BCDX2 complex formation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11563", "l": "(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+) <=> catechol + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211983", "l": "CYP2J2 oxidises ARA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.46"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247843", "l": "secretion of WNT ligands (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24025", "l": "(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate => (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63766", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052807", "l": "aflatoxin reductase (coenzyme F420) activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033838", "l": "flavonol-3-O-glucoside glucosyltransferase activity"}, {"i": "RHEA:18893", "l": "a flavonol 3-O-beta-D-glucoside + UDP-alpha-D-glucose = a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP"}, {"i": "EC:2.4.1.239", "l": "\"Flavonol-3-O-glucoside glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30987", "l": "(S)-2,3-epoxysqualene = (17Z)-protosta-17(20),24-dien-3beta-ol"}, {"i": "EC:5.4.99.32", "l": "\"Protostadienol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62759", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57267", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP <=> GDP + glycolate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-190141", "l": "ALAD binds to Pb2+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8870469", "l": "RGGT geranylgeranylates RAB proteins (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42275", "l": "3-methylbutanoyl-CoA + H(+) + malonyl-[ACP] <=> 5-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65879", "l": "5alpha-androst-1-ene-3,17-dione + H2O <=> 1-hydroxy-5alpha-androstan-3,17-dione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48935", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1b <=> CMP + ganglioside GQ1b + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5334794", "l": "FABPs bind LCFAs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004621", "l": "glycosylphosphatidylinositol phospholipase D activity"}, {"i": "RHEA:10832", "l": "a 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)"}, {"i": "EC:3.1.4.50", "l": "\"Glycosylphosphatidylinositol phospholipase D\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684169", "l": "G6B binds PTPN6,PTPN11 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62568", "l": "H2O + S-benzyl-L-cysteinylglycine = glycine + S-benzyl-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635854", "l": "GLI2,3 are degraded by the proteasome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66886", "l": "11-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57632", "l": "ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + ML-236A carboxylate + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008405", "l": "arachidonic acid 11,12-epoxygenase activity"}, {"i": "RHEA:51480", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55198", "l": "formyl-CoA + heptadecanal => 2-hydroxyoctadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045145", "l": "single-stranded DNA 5'-3' exodeoxyribonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975122", "l": "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3262512", "l": "G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607758", "l": "CLEC7A binds 1,3-beta-D-glucan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19671", "l": "GDP + H(+) + phosphate => GTP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56002", "l": "beta-D-glucose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) => H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357845", "l": "RIPK1 is deubiquitinated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047166", "l": "1-alkenylglycerophosphoethanolamine O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684340", "l": "3CLp cleaves pp1ab (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56707", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 <=> 3-[(E)-2-isocyanovinyl]indole + 2 CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14801", "l": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP"}, {"i": "EC:2.7.2.3", "l": "\"Phosphoglycerate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202703", "l": "CD47 binds SIRP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59516", "l": "acetylsalicylate + L-lysyl-[protein] = H(+) + N(6)-acetyl-L-lysyl-[protein] + salicylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64465", "l": "L-tyrosyl-[protein] + 2 O2 => H(+) + H2O2 + L-topaquinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38949", "l": "12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11054", "l": "4-aminophenol + CO2 + H2O + NAD(+) => 4-aminobenzoate + 2 H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.21", "l": "\"Polo kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.104", "l": "\"Peptidoglycan-N-acetylglucosamine deacetylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033953", "l": "alpha-agarase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990380", "l": "Lys48-specific deubiquitinase activity"}, {"i": "REACT:R-HSA-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810643", "l": "EPPIN protein complex binds bacteria (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018613", "l": "9-fluorenone dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18838", "l": "10-deacetyltaxuyunnanin C + acetyl-CoA => CoA + taxuyunnanin C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948775", "l": "MKRN1 polyubiquitinates PTEN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018525", "l": "4-hydroxybenzoyl-CoA reductase activity"}, {"i": "MetaCyc:OHBENZCOARED-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63426", "l": "(2S)-lactyl-2-diphospho-5'-guanosine + diphosphate => (2S)-2-phospholactate + GTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850961", "l": "PREX2 binds PTEN and inhibits it (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210662", "l": "Phosphorylated HOP is dephosphorylated by PTP61F isoform 1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31399", "l": "all-trans-4,4'-diapophytofluene + FAD + H(+) = all-trans-4,4'-diapo-zeta-carotene + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665727", "l": "FMNL2 binds CDC42:GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.3.7", "l": "\"Tetrahydrocannabinolic acid synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16862", "l": "(S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine => (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61317", "l": "germacra-1(10),4,11(13)-trien-12-al + O2 + reduced [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61147", "l": "myricetin + UDP-beta-L-rhamnose <=> H(+) + myricetin 3-O-alpha-L-rhamnoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42597", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 => prostaglandin G2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57322", "l": "CoA + H(+) + N-terminal N-acetyl-L-(Asp/Glu)3-[protein] => acetyl-CoA + N-terminal L-(Asp/Glu)3-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28198", "l": "(S)-1-phenylethanol + NAD(+) = acetophenone + H(+) + NADH"}, {"i": "EC:1.1.1.311", "l": "\"(S)-1-phenylethanol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112385", "l": "Addition of nucleotides leads to transcript elongation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218642", "l": "PTK2 autophosphorylates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47269", "l": "bacterioruberin => H2O + monoanhydrobacterioruberin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201637", "l": "Caspase-mediated cleavage of plectin-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948602", "l": "miR-19a microRNA binds CNOT6L mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60998", "l": "4-methyl-2-oxopentanoate + H2O2 + NH4(+) => H2O + L-leucine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53942", "l": "18-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12680", "l": "AH2 + Latia luciferin + 2 O2 <=> A + CO2 + formate + H(+) + H2O + hnu + oxidized Latia luciferin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990465", "l": "aldehyde oxygenase (deformylating) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902387", "l": "ceramide 1-phosphate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20928", "l": "[DsbA protein]-dithiol + a quinone = [DsbA protein]-disulfide + a quinol"}, {"i": "EC:1.8.5.9", "l": "\"Protein dithiol:quinone oxidoreductase DsbB\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003839", "l": "gamma-glutamylcyclotransferase activity"}, {"i": "REACT:R-HSA-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.1.3.-", "l": "\"Hydron translocation linked to the hydrolysis of diphosphate\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42407", "l": "H2O + lactose 6-phosphate <=> beta-D-glucose + D-galactose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203662", "l": "eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193703", "l": "IKKbeta is activated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180630", "l": "Association of APOBEC3G with Gag (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45945", "l": "12-methyltridecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(13-methyl-2-oxotetradecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51848", "l": "8-methylmenaquinone-6 + succinate = 8-methylmenaquinol-6 + fumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20214", "l": "L-lysyl-[lipoyl-carrier protein] + N(6)-octanoyl-L-lysyl-[glycine-cleavage complex H protein] => L-lysyl-[glycine-cleavage complex H protein] + N(6)-octanoyl-L-lysyl-[lipoyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54522", "l": "cycloaraneosene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28499", "l": "formaldehyde + mycothiol => S-(hydroxymethyl)mycothiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668481", "l": "Protesomal degradation of K48polyUb-TRAF3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48391", "l": "alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose <=> alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018516", "l": "2,4-dichlorobenzoyl-CoA reductase activity"}, {"i": "MetaCyc:1.3.1.63-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10907", "l": "[cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A <=> AH2 + C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen sulfide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20195", "l": "H(+) + mevaldate + NADPH => (R)-mevalonate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55369", "l": "(R)-carnitine + H(+) + NADPH + O2 => (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63114", "l": "AH2 + ascofuranone => A + ascofuranol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67118", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9637635", "l": "esxA binds B2M (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428534", "l": "Recruitment of Profilin by Ena/VASP proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50488", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426223", "l": "Cation influx mediated by TRPC3/6/7 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62614", "l": "H(+) + N(6)-methyladenosine(1832) in 18S rRNA + S-adenosyl-L-homocysteine => adenosine(1832) in 18S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43753", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein uS5] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein uS5]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-434650", "l": "MATEs mediate extrusion of xenobiotics (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37045", "l": "ADP + H(+) + L-alanyl-L-glutamate(in) + phosphate => ATP + H2O + L-alanyl-L-glutamate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042951", "l": "arbutin transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216048", "l": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54899", "l": "(10Z,15Z)-12-oxophytodienoate + ATP + CoA <=> (10Z,15Z)-12-oxophytodienoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31568", "l": "bisphenol A + H(+) + NADH + O2 => 2,2-bis(4-hydroxyphenyl)-1-propanol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33301", "l": "[eIF5A protein]-deoxyhypusine + propane-1,3-diamine => [eIF5A protein]-L-lysine + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67089", "l": "ATP + H2O + tetracosanoate(in) => ADP + H(+) + phosphate + tetracosanoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61837", "l": "ergosterol + UDP-alpha-D-glucose => ergosteryl 3-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.3.13"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37551", "l": "3-dehydro-D-glucose 6-phosphate + L-glutamate = 2-oxoglutarate + D-kanosamine 6-phosphate"}, {"i": "EC:2.6.1.104", "l": "\"3-dehydro-glucose-6-phosphate--glutamate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212642", "l": "L-Glutamine transport into neurons (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675815", "l": "PI4P transports from the Golgi membrane to the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240777", "l": "E2F1/2/3:DP1/2 binds EZH2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191784", "l": "snRNA Cap hypermethylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59949", "l": "H2O + prostaglandin F2alpha-CoA => CoA + H(+) + prostaglandin F2alpha"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13900", "l": "chorismate <=> prephenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166869", "l": "TRAF6 binds MEKK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66042", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (9Z,12Z)-octadecadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39095", "l": "(3S)-hydroxydecanedioyl-CoA + NAD(+) = 3-oxodecanedioyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32421", "l": "(1S,4R)-isodihydrocarvone + H(+) + NADH => (1S,2R,4R)-neoisodihydrocarveol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050528", "l": "acyloxyacyl hydrolase activity"}, {"i": "RHEA:12032", "l": "a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)"}, {"i": "EC:3.1.1.77", "l": "\"Acyloxyacyl hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420724", "l": "CASR binds Ca2+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45143", "l": "2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O <=> CO2 + L-glutamyl-[protein] + O2 + phylloquinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17488", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35054", "l": "N,N'-diacetylchitobiose(out) <=> N,N'-diacetylchitobiose(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625416", "l": "Anterograde IFT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034788", "l": "2,3-dihydroxy-2'-carboxybiphenyl 1,2-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22584", "l": "2 H(+) + heme b = Fe(2+) + protoporphyrin IX"}, {"i": "EC:4.99.1.1", "l": "\"Protoporphyrin ferrochelatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534160", "l": "HSPG2 (perlecan) degradation by MMP13, CTSS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952069", "l": "HDAC4 deacetylates RUNX3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53991", "l": "H2O + O-phospho-L-threonyl-[myosin light chain] <=> L-threonyl-[myosin light chain] + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047417", "l": "N-carbamoyl-D-amino acid hydrolase activity"}, {"i": "RHEA:11000", "l": "an N-carbamoyl-D-amino acid + 2 H(+) + H2O = a D-alpha-amino acid + CO2 + NH4(+)"}, {"i": "EC:3.5.1.77", "l": "\"N-carbamoyl-D-amino-acid hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5220959", "l": "TDG excises 5-formylcytosine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62976", "l": "(9Z,12Z,15Z)-octadecatrienamide + H2O = (9Z,12Z,15Z)-octadecatrienoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9633005", "l": "EIF2AK4 (GCN2) binds tRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31294", "l": "(S)-malate + FAD + H(+) <=> FADH2 + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2219524", "l": "PDPK1 binds PIP2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696271", "l": "RND1 binds effectors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55748", "l": "coenzyme B + coenzyme M + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.8.98.5", "l": "\"H(2):CoB-CoM heterodisulfide,ferredoxin reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33870", "l": "(S)-2-ureidoglycine + glyoxylate <=> glycine + N-carbamoyl-2-oxoglycine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017042", "l": "glycosylceramidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45104", "l": "6-demethylmitomycin A + S-adenosyl-L-methionine = mitomycin A + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45685", "l": "N-dodecanoyl-sphing-4-enine-1-phosphate(in) => N-dodecanoyl-sphing-4-enine-1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51861", "l": "(2E)-geranyl diphosphate + umbelliferone => 8-geranylumbelliferone + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23672", "l": "a quinone + L-quinate = 3-dehydroquinate + a quinol"}, {"i": "EC:1.1.5.8", "l": "\"Quinate/shikimate dehydrogenase (quinone)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202534", "l": "Ubiquitination of NEMO by TRAF6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140761", "l": "sequestered tissue factor -> tissue factor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-990528", "l": "Interaction of PCBP2 with MAVS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237160", "l": "MTA is cleaved and phosphorylated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2396395", "l": "HSPG2 (perlecan) binds alpha-dystroglycan (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50015", "l": "H(+) + NADPH + O2 + tert-butanol <=> 2-methylpropane-1,2-diol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61347", "l": "H2O + L-serine + O2 <=> 3-hydroxypyruvate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5687088", "l": "PKA phosphorylates MAPKAPK5 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42659", "l": "diphthine methyl ester-[translation elongation factor 2] + H2O <=> diphthine-[translation elongation factor 2] + H(+) + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62179", "l": "GDP-alpha-D-glucose + H2O <=> alpha-D-glucose 1-phosphate + GMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17879", "l": "a guaiacol + H(+) + S-adenosyl-L-homocysteine => a catechol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396399", "l": "Fibrillins bind BMPs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71495", "l": "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730856", "l": "Autophosphorylation of PAK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13336", "l": "beta-D-fructose 2,6-bisphosphate + H2O <=> beta-D-fructose 2-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624951", "l": "TNPO1 binds KIF17 dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-176973", "l": "Association of MCM8 with ORC:origin complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374896", "l": "Uptake of Noradrenaline (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42504", "l": "2-oxoglutarate + N(6)-acetyl-L-lysine = 6-acetamido-2-oxohexanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948709", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52546", "l": "2-dehydro-D-erythronate + H(+) + NADH => D-erythronate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451856", "l": "FT is phosphorylated by DCO (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40658", "l": "(R)-malate + succinyl-CoA <=> (R)-malyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60226", "l": "2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18159", "l": "ADP + H(+) + phosphoenolpyruvate => ATP + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34200", "l": "2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 => bracteatin 6-O-beta-glucoside + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47155", "l": "2,5-dioxopentanoate + H2O + NAD(+) <=> 2-oxoglutarate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16836", "l": "2 glutathione + H2O2 <=> glutathione disulfide + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47774", "l": "a 2'-O-methylguanosine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine => a guanosine in 21S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.28", "l": "\"Tropomyosin kinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0016215", "l": "acyl-CoA desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23927", "l": "pppGp(2'-5')A <=> 2',3'-cGAMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692755", "l": "CDK1 phosphorylates MAPK6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.232", "l": "\"Initiation-specific alpha-1,6-mannosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23347", "l": "a purine D-ribonucleoside + H2O <=> a purine nucleobase + D-ribose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381727", "l": "RAP1A exchanges GDP for GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30388", "l": "GDP-alpha-D-glucose + phosphate => alpha-D-glucose 1-phosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25600", "l": "5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate <=> (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193695", "l": "IRAK interacts with TRAF6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19656", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NAD(+) <=> CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9612219", "l": "ERBB4s80 binds to SRC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391913", "l": "FPR2 binds FPR2 ligands (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49524", "l": "2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2 = a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate"}, {"i": "EC:1.14.11.51", "l": "\"DNA N(6)-methyladenine demethylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45706", "l": "(E)-sinapoaldehyde + H(+) + NADPH => (E)-sinapoyl alcohol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.-", "l": "\"With NADH or NADPH as one donor, and incorporation of one atom of oxygen\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201790", "l": "DARPP-32 is dephosphorylated on Thr75 by PP2A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392748", "l": "L1 binds to AP-2 Clathrin complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052925", "l": "dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"}, {"i": "MetaCyc:RXN-5466"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71783", "l": "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166387", "l": "The FA anion diffuses away laterally from UCP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013108", "l": "GDIs block activation of RHOC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0044388", "l": "small protein activating enzyme binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353056", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11984", "l": "AH2 + O2 + progesterone = A + H2O + testosterone acetate"}, {"i": "EC:1.14.99.4", "l": "\"Progesterone monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.28"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47225", "l": "3beta-sulfooxy-androst-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] => 3beta-sulfooxy-16alpha-hydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58189", "l": "all-trans-lycopene + dimethylallyl diphosphate + H2O => dihydroisopentenyldehydrorhodopin + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418662", "l": "Src activation following P2Y purinoceptor activation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031789", "l": "G protein-coupled acetylcholine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30747", "l": "FAD + H(+) + hexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72139", "l": "Formation of the active Spliceosomal C (B*) complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28786", "l": "H2O + L-cysteinylglycine <=> glycine + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40143", "l": "(9Z,12Z)-octadecadienoyl-CoA + H2O = (9Z,12Z)-octadecadienoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38378", "l": "bacterioruberin <=> bisanhydrobacterioruberin + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1299338", "l": "Activation of TRESK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42793", "l": "cholesterol + hexadecanoyl-CoA => cholesteryl hexadecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444100", "l": "PROT mediates L-proline uptake (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30909", "l": "2-methylbutanoyl-CoA + CO2 + NADH => (S)-3-methyl-2-oxopentanoate + CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51316", "l": "(9Z)-octadecenoate + glycine = H2O + N-(9Z-octadecenoyl)glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109857", "l": "MAP2K1 binds MAPK3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66535", "l": "ATP + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] <=> diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13662", "l": "H2O + N-formimidoyl-L-aspartate => N-formyl-L-aspartate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35544", "l": "3-phosphooxypyruvate + H2O => 3-hydroxypyruvate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30603", "l": "15-cis-phytoene + A = AH2 + all-trans-phytofluene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853793", "l": "p-5Y-RET complexes bind GRB2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71849", "l": "LDH tetramer reduces PYR to LACT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.46", "l": "\"Complement factor D\""}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0052670", "l": "geraniol kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25141", "l": "3-amino-2-oxopropyl phosphate + CO2 => (2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36528", "l": "(11Z)-eicosenoyl-CoA + H(+) + malonyl-CoA => (13Z)-3-oxodocosenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158340", "l": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018531", "l": "(S)-6-hydroxynicotine oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804383", "l": "PRMT5 methylates TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20382", "l": "3alpha-hydroxy-5alpha-androstan-17-one + NAD(+) => 5alpha-androstan-3,17-dione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49788", "l": "chenodeoxycholoyl-CoA + glycine = CoA + glycochenodeoxycholate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.1.1", "l": "\"Rubredoxin--NAD(+) reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59901", "l": "2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 => CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205075", "l": "JNK phosphorylates BIM, BAD and other targets (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44273", "l": "3 H(+) + 3 malonyl-CoA + octadecanoyl-CoA => 4-hydroxy-6-(2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051525", "l": "NFAT protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64653", "l": "(E)-4-coumaraldehyde + CoA + NADP(+) => (E)-4-coumaroyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47742", "l": "CO2 + demethylphylloquinone + diphosphate => 1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071861", "l": "tachykinin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939201", "l": "ESR dimerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-383190", "l": "HCO3- transport through ion channel (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852200", "l": "Inactivation of LCK by PTPN22 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18747", "l": "2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) => 2 juglone + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5334827", "l": "SUMO-CRABP2 binds atRA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13911", "l": "alpha-D-ribose 1-phosphate + urate => phosphate + urate D-ribonucleoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218812", "l": "FYN phosphorylates PAK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9650165", "l": "ASIC trimers bind H+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785181", "l": "LMF1,2 bind LIPC dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009916", "l": "alternative oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53670", "l": "(1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847977", "l": "FRK phosphorylates PTEN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39958", "l": "(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-688985", "l": "K63 polyubiquitinated RIP2 associates with the TAK1 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.205"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174157", "l": "Degradation of multiubiquitinated Cyclin B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33055", "l": "guanosine 3'-diphosphate 5'-triphosphate + H2O = diphosphate + GTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5681980", "l": "ATG12 binds ATG7 dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14724", "l": "UDP-alpha-D-xylose + zeatin <=> H(+) + O-beta-D-xylosylzeatin + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60758", "l": "cinerin I + CoA => (1R,3R)-chrysanthemoyl-CoA + (Z,S)-cinerolone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20154", "l": "ATP + L-arabinose => ADP + beta-L-arabinose 1-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21904", "l": "(2R)-2,3-bisphosphoglycerate + H2O = (2R)-3-phosphoglycerate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66628", "l": "(2S,4S,5S)-2-amino-6-(3,4-dihydroxyphenyl)-4-hydroxy-5-(methylamino)hexanoyl-[peptidyl-carrier protein] + O2 = (2S,4S)-2-amino-4-[(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]-4-hydroxybutanoyl-[peptidyl-carrier protein] + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16142", "l": "2'-deoxymugineate + NAD(+) => 3''-deamino-3''-oxonicotianamine + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40602", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> a 2-acyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951442", "l": "CTNNB1:TCF7L2,LEF1 binds the CCND1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42602", "l": "A + H2O + prostaglandin H2 => AH2 + prostaglandin G2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "80.661393760018115", "identifiers": [{"i": "GO:0016774", "l": "phosphotransferase activity, carboxyl group as acceptor"}, {"i": "EC:2.7.2.-", "l": "\"Phosphotransferases with a carboxy group as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975040", "l": "KRAB-ZNF / KAP Interaction (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205231", "l": "Dimerization of KIT upon SCF binding (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382057", "l": "Release of novel PDGFs as latent factors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209891", "l": "Dopamine is oxidised to noradrenaline (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39164", "l": "3-oxohexadecanoyl-CoA + H(+) + NADPH => (3R)-hydroxyhexadecanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19043", "l": "(25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033945", "l": "oligoxyloglucan reducing-end-specific cellobiohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31107", "l": "3-phenylpyruvate + O2 = (2-hydroxyphenyl)acetate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56264", "l": "CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = CMP + H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-452091", "l": "Phosphorylation of IL2RB Y338 enables SHC recruitment (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786650", "l": "DDHD1,2 hydrolyse PA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621425", "l": "Defective AVP mutants do not bind AVPR1A,B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167674", "l": "Binding of PLCG1 to active TrkA receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050192", "l": "phosphoglycerate phosphatase activity"}, {"i": "KEGG.REACTION:R01748"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9670673", "l": "FIX is secreted (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0140394", "l": "ABC-type azole transporter activity"}, {"i": "RHEA:33503", "l": "ATP + H2O + itraconazole(in) = ADP + H(+) + itraconazole(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34928", "l": "H(+) + NADPH + selenodiglutathione => glutathione + glutathioselenol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42476", "l": "2,2',3-trihydroxydiphenyl ether + H(+) + O2 = 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-532549", "l": "MPI isomerises Fru6P to Man6P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66702", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + AMP + diphosphate => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.92", "l": "\"3,6-anhydro-alpha-L-galactose dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52196", "l": "(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] = 1-aci-nitro-2-(phenyl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047439", "l": "3-deoxy-D-manno-octulosonate aldolase activity"}, {"i": "RHEA:23340", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate = D-arabinose + pyruvate"}, {"i": "EC:4.1.2.23", "l": "\"3-deoxy-D-manno-octulosonate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14540", "l": "1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H(+) + H2O <=> 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2152276", "l": "Secretion of transmembrane collagens (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23621", "l": "ATP + N(2)-(2-carboxyethyl)-L-arginine => AMP + deoxyamidinoproclavaminate + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047898", "l": "formate dehydrogenase (cytochrome) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781840", "l": "ERCC6 binds stalled RNA Pol II (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50850", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43404", "l": "N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose = H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56709", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19761", "l": "FMN-N(5)-oxide + H(+) + NADH = FMN + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16841", "l": "precorrin-2 + S-adenosyl-L-methionine = H(+) + precorrin-3A + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.130", "l": "\"Precorrin-2 C(20)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050600", "l": "myristoyl-CoA 11-(E) desaturase activity"}, {"i": "RHEA:46396", "l": "2 [Fe(II)-cytochrome b5] + an 11,12-saturated fatty acyl-CoA + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + an (11E)-Delta(11)-fatty acyl-CoA + 2 H2O"}, {"i": "EC:1.14.19.24", "l": "\"Acyl-CoA 11-(E)-desaturase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033842", "l": "N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865547", "l": "RUNX1:CBFB binds FOXP3 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199046", "l": "Ligands bind L-selectin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31220", "l": "5-hydroxykynurenamine + CO2 => 5-hydroxy-L-kynurenine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57159", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 <=> 4-hydroxy-L-lysyl-[protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3927959", "l": "SUMOylation of CREBBP with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202472", "l": "Translocation of TRAF6 to CBM complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964280", "l": "Active Gq binds BTK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982792", "l": "Growth hormone receptor binds JAK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48728", "l": "3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+) = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24662", "l": "H2O + N(omega)-hydroxy-L-arginine + NADP(+) => H(+) + L-arginine + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66720", "l": "ATP + H2O + N-[(S)-lactoyl]-L-phenylalanine(in) = ADP + H(+) + N-[(S)-lactoyl]-L-phenylalanine(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050138", "l": "nicotinate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16589", "l": "A + sucrose = 3-dehydro-alpha-D-glucosyl beta-D-fructofuranoside + AH2"}, {"i": "EC:1.1.99.13", "l": "\"Glucoside 3-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674385", "l": "p-T,Y MAPKs dimerize (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15612", "l": "ATP + D-ribose 5-phosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53032", "l": "2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 2-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35785", "l": "H(+) + kanamycin B + UDP => neamine + UDP-alpha-D-kanosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4615910", "l": "SUMOylation of PCNA with SUMO1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030350", "l": "iron-responsive element binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004911", "l": "interleukin-2 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59315", "l": "D-galactose + O2 <=> D-galactono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31188", "l": "(3S)-hydroxydecanoyl-CoA + NAD(+) => 3-oxodecanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56679", "l": "dihydroferuloyl-CoA + NADP(+) <=> (E)-feruloyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018679", "l": "dibenzothiophene-5,5-dioxide monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421831", "l": "trans-Golgi Network Coat Assembly (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034278", "l": "stemar-13-ene synthase activity"}, {"i": "RHEA:25552", "l": "9alpha-copalyl diphosphate = diphosphate + stemar-13-ene"}, {"i": "EC:4.2.3.33", "l": "\"Stemar-13-ene synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015047", "l": "NADPH-cytochrome-c2 reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47972", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O"}, {"i": "EC:4.2.1.159", "l": "\"dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17940", "l": "dihydroxyacetone phosphate <=> methylglyoxal + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198669", "l": "p38MAPK phosphorylates MSK1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40078", "l": "6-amino-6-deoxyfutalosine + H(+) + H2O <=> futalosine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61834", "l": "H(+) + sitosteryl 3-beta-D-glucoside + UDP => (24R)-ethylcholest-5-en-3beta-ol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15317", "l": "a 2-deoxy-alpha-D-glucoside + H2O = 2-deoxy-D-glucose + an alcohol"}, {"i": "EC:3.2.1.112", "l": "\"2-deoxyglucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29216", "l": "fumarate + menaquinol-8 => menaquinone-8 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51206", "l": "12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH => 6-trans-leukotriene B4 + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12051", "l": "3-oxoadipate + succinyl-CoA <=> 3-oxoadipyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296309", "l": "HCAR3 binds HCAR3 ligands (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64927", "l": "dATP + 2 H2O <=> dAMP + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.13", "l": "\"ABC-type D-xylose/L-arabinose transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1562604", "l": "BfrA stores iron (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39779", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60229", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047143", "l": "chlorate reductase activity"}, {"i": "RHEA:16349", "l": "AH2 + chlorate = A + chlorite + H2O"}, {"i": "EC:1.97.1.1", "l": "\"Chlorate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35418", "l": "an anthocyanidin 3-O-beta-D-sambubioside + UDP-alpha-D-glucose <=> an anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46574", "l": "5-hexenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + hexanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12821", "l": "2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate"}, {"i": "EC:4.1.2.4", "l": "\"Deoxyribose-phosphate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63230", "l": "9-O-adenylylspectinomycin + diphosphate => ATP + spectinomycin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63541", "l": "H2O + neurotensin => L-leucine + neurotensin-(1-12)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204500", "l": "CyP60 chaperones Basigin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2213201", "l": "Formation of collagen fibres (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047460", "l": "L-2-amino-4-chloropent-4-enoate dehydrochlorinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21482", "l": "5-hydroxy-2-furoyl-CoA + AH2 + H(+) => 2-furoyl-CoA + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022314", "l": "HIPK2 phosphorylates MECP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29493", "l": "cis-muurola-4(14),5-diene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008157", "l": "protein phosphatase 1 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5668545", "l": "NIK autophosphorylates on T559 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004862", "l": "cAMP-dependent protein kinase inhibitor activity"}, {"i": "REACT:R-HSA-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20934", "l": "dihydroxyacetone phosphate + formaldehyde => L-erythrulose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61067", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-glucosamine <=> beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358789", "l": "Self-ubiquitination of RNF41 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374701", "l": "Phosphorylation of DCC by Fyn (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012835", "l": "GDIs block activation of RHOA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209973", "l": "Tyrosine is diiodinated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202375", "l": "Recruitment of ITK to SLP-76 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24140", "l": "guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.185", "l": "\"23S rRNA (guanosine(2251)-2'-O)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35253", "l": "ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + H(+) + phosphate => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784734", "l": "PCSK9 binds LDLR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45517", "l": "[phycoerythrocyanin beta-subunit]-Cys(155)-phycocyanobilin => (2R,3E)-phycocyanobilin + apo-[phycoerythrocyanin beta-subunit]-Cys(155)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865320", "l": "CBFB binds RUNX1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168184", "l": "Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32313", "l": "(E)-4-hydroxyphenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-tyrosine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23722", "l": "(S)-methylmalonyl-CoA + ADP + H(+) + phosphate => ATP + hydrogencarbonate + propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977629", "l": "Displacement of C2a/Bb by CR1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43224", "l": "(24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = (24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682992", "l": "KDM4A,B bind H4K20Me2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604763", "l": "Autocatalytic activation of MMP7 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17798", "l": "[(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose => [(1->4)-beta-D-glucosyl](n+1) + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114684", "l": "Phosphorylation of Syntaxin-4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102275", "l": "cysteine-S-conjugate N-malonyl transferase activity"}, {"i": "MetaCyc:RXN-12534"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21673", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine => [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51281", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58507", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate <=> (3Z)-2-oxo-4-carboxy-3-hexenedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17914", "l": "H2O + NAD(+) + nitrite => H(+) + NADH + nitrate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001791", "l": "IgM binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624668", "l": "CEBPA binds CDKN1A (p21) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183072", "l": "EGFR non-clathrin mediated endocytosis (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34392", "l": "beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 UDP-alpha-D-galactofuranose => [beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 H(+) + 28 UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725338", "l": "NPM-ALK-dependent BCL2A1 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23542", "l": "AMP + diphosphate + L-glutamyl-tRNA(Glu) => ATP + L-glutamate + tRNA(Glu)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0008200", "l": "ion channel inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52209", "l": "alachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + methyl formate + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9612219", "l": "ERBB4s80 binds to SRC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9609921", "l": "SGTA binds Tail-anchored protein (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60080", "l": "4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2 = 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47035", "l": "AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA <=> 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9664850", "l": "ATM binds PEX5 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46126", "l": "(24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37384", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31403", "l": "all-trans-4,4'-diapo-zeta-carotene + FAD + H(+) = all-trans-4,4'-diaponeurosporene + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33708", "l": "ATP + L-threonine => ADP + H(+) + O-phospho-L-threonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59708", "l": "D-maltotriono-1,5-lactone + H2O = D-maltotrionate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38693", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21105", "l": "AH2 + cholesterol + O2 => 25-hydroxycholesterol + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35714", "l": "acetate + succinyl-CoA <=> acetyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56886", "l": "2'-O-methyladenosine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine => adenosine(32) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44737", "l": "acetyl-CoA + dihydroxyacetone phosphate => 3-hydroxy-2,4-dioxopentyl phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20967", "l": "2-oxoglutarate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63716", "l": "losartan + UDP-alpha-D-glucuronate = losartan-1-N-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694436", "l": "nsp15 forms a hexamer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10246", "l": "acetoacetate + fumarate + H(+) => 4-fumarylacetoacetate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807585", "l": "BPI binds LPS on the bacterial surface (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54356", "l": "3-methyl-2-oxobutanoate + H(+) = 2-methylpropanal + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.142"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22978", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11398", "l": "5-methyldeoxycytidine diphosphate + ADP => 5-methyldeoxycytidine 5'-phosphate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33031", "l": "D-fructose + H(+) + NADH = D-sorbitol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952419", "l": "SMURFs ubiquitinate RUNX3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961915", "l": "CDC45 gene expression is stimulated by E2F1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15327", "l": "a 1-acyl-sn-glycero-3-phosphate + CoA => an acyl-CoA + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54744", "l": "9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173709", "l": "C7 binds C5b:C6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32915", "l": "sn-glycero-3-phospho-1D-myo-inositol(out) = sn-glycero-3-phospho-1D-myo-inositol(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198714", "l": "ERK5 translocates to the nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047581", "l": "4-methyleneglutamate-ammonia ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55512", "l": "cucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxycucurbitadienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690701", "l": "SHP1 binds p-CD22 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32413", "l": "(1R,4S)-isodihydrocarvone + H(+) + NADH => (1R,2R,4S)-isodihydrocarveol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53661", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 => (5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64115", "l": "an N-acyl-L-phenylalanine + H2O <=> a fatty acid + L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047412", "l": "N-(long-chain-acyl)ethanolamine deacylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39294", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11536", "l": "choline + H2O + 2 O2 = glycine betaine + H(+) + 2 H2O2"}, {"i": "EC:1.1.3.17", "l": "\"Choline oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191790", "l": "Loading and methylation of Sm proteins onto SMN Complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085083", "l": "Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989775", "l": "Expression of SULT2A1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202717", "l": "Heterodimerization of CEACAMs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23209", "l": "acetyl-CoA + trans-glutaconate => (2E)-glutaconyl-CoA + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9609921", "l": "SGTA binds Tail-anchored protein (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33122", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-sativene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13867", "l": "beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+) => GDP-alpha-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58609", "l": "2 L-ascorbate + N-decanoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-decanoyl-(2S)-hydroxyglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56383", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 chloride + 2 FADH2 + 2 O2 <=> (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 FAD + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21948", "l": "formamide + H2O = formate + NH4(+)"}, {"i": "EC:3.5.1.49", "l": "\"Formamidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47165", "l": "4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) => CO2 + NADH + zymosterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706364", "l": "Internalization of ubiquitinated FLT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58978", "l": "3-oxopropanoate + H(+) + H2O2 => H2O + malonaldehyde + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51283", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate <=> (9S)-hydroperoxy-(10E,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21639", "l": "(E)-4-coumarate + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-trans-4-coumarate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086393", "l": "G alpha t2 binds and activates PDE6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15500", "l": "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate <=> 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016403", "l": "dimethylargininase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.7", "l": "\"DNA-directed DNA polymerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34797", "l": "alpha-D-ribose 1,5-bisphosphate + H(+) => alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42496", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate = 10-deacetyl-2-debenzoylbaccatin III"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202443", "l": "Oligomerization of CARMA1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686430", "l": "MUS81 binds EME1, EME2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30250", "l": "2 H2O + 4 hnu + 2 plastoquinone-9 <=> O2 + 2 plastoquinol-9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40243", "l": "(3R)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66797", "l": "miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 11-oxomiltiradiene + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21459", "l": "(S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802938", "l": "Inhibitors bind and inhibit highly active BRAF mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62644", "l": "(5Z,8Z)-eicosadienoate + O2 = (5S)-hydroperoxy-(6E,8Z)-eicosadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20357", "l": "3-phenylpropanoate + H(+) + NADH + O2 = 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)"}, {"i": "RHEA:25058", "l": "(E)-cinnamate + H(+) + NADH + O2 = (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)"}, {"i": "EC:1.14.12.19", "l": "\"3-phenylpropanoate dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56799", "l": "[corrinoid adenosyltransferase]-cob(I)alamin + ATP <=> adenosylcob(III)alamin + apo-[corrinoid adenosyltransferase] + triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983156", "l": "Polyubiquitination of substrate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419490", "l": "Binding of ATP to P2X receptors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51144", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + 2 O2 = (10,17)-dihydroperoxy-(7Z,11Z,13Z,15E,19Z)-docosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33642", "l": "ATP + CoA + tetracosanoate <=> AMP + diphosphate + tetracosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1462014", "l": "Alpha-defensins form biologically active dimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30465", "l": "(+)-alpha-santalene + diphosphate => (2Z,6Z)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000433", "l": "SUMOylation of PML with SUMO3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59204", "l": "docosanoyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] = AMP + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48867", "l": "2-methylpropan-1-amine + FADH2 + O2 <=> FAD + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56979", "l": "4-methylphenol + H2O + 2 oxidized [azurin] <=> 4-hydroxybenzyl alcohol + 2 H(+) + 2 reduced [azurin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16426", "l": "formaldehyde + H2O + NAD(+) => formate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202222", "l": "Phosphorylation of PKC theta (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58030", "l": "a mycoketide-CoA + 10 CO2 + 10 CoA + 11 H2O + 22 NADP(+) => 5 (S)-methylmalonyl-CoA + a medium-chain fatty acyl-CoA + 32 H(+) + 5 malonyl-CoA + 22 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357472", "l": "PAK1-3 autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18547", "l": "glycolaldehyde + pyruvate => 2-dehydro-3-deoxy-L-arabinonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50587", "l": "13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) <=> 15-oxoprostaglandin E1 + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853793", "l": "p-5Y-RET complexes bind GRB2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140662", "l": "ATP-dependent protein folding chaperone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27837", "l": "a menaquinone + succinate <=> a menaquinol + fumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6795290", "l": "TORC2 complex phosphorylates SGK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63545", "l": "H2O + kinetensin => kinetensin-(1-8) + L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63657", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24869", "l": "5'-deoxyadenosine + phosphate = 5-deoxy-alpha-D-ribose 1-phosphate + adenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45434", "l": "H(+) + N-(9Z-octadecenoyl) ethanolamine + sn-glycerol 3-phosphate => H2O + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209910", "l": "Iodide is taken up by thyroid epithelial cells (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21819", "l": "a D-alpha-amino acid + H2O + O2 <=> a 2-oxocarboxylate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64562", "l": "butan-2-one + H(+) + NADH => butan-2-ol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34763", "l": "(S,S)-tartrate(out) + succinate(in) = (S,S)-tartrate(in) + succinate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30526", "l": "GTP + L-glutamate + oxidized coenzyme F420-1 <=> GDP + H(+) + oxidized coenzyme F420-2 + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016509", "l": "long-chain-3-hydroxyacyl-CoA dehydrogenase activity"}, {"i": "REACT:R-HSA-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20283", "l": "adenosine 3',5'-bisphosphate + glucotropeolin + H(+) => 3'-phosphoadenylyl sulfate + desulfoglucotropeolin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712199", "l": "cAMP binds the olfactory CNG channel (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32616", "l": "(6E)-8-oxogeraniol + NADP(+) => (6E)-8-oxogeranial + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22725", "l": "a sterol + UDP-alpha-D-glucose => a sterol 3-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53375", "l": "5,6-dihydrouridine(17) in tRNA + NAD(+) <=> H(+) + NADH + uridine(17) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13288", "l": "ATP + L-cysteine + L-glutamate <=> ADP + H(+) + L-gamma-glutamyl-L-cysteine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41583", "l": "5,10-dihydrophenazine 1-carboxylate + dimethylallyl diphosphate <=> 5,10-dihydro-9-dimethylallylphenazine 1-carboxylate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103066", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43555", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5333671", "l": "CLCAs self cleave (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374673", "l": "L1 binds RanBPM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32534", "l": "4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate <=> alpha-D-mannose 1-phosphate + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11782", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43524", "l": "L-allo-threonine + NADP(+) = aminoacetone + CO2 + NADPH"}, {"i": "EC:1.1.1.381", "l": "\"3-hydroxy acid dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60104", "l": "3-(1H-indol-3-yl)propanoate + H(+) + oxidized [electron-transfer flavoprotein] = (E)-3-(indol-3-yl)acrylate + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36973", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-allose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607744", "l": "MALT1 binds BCL10 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9612501", "l": "SGK phosphorylates CREB1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202127", "l": "eNOS synthesizes NO (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210294", "l": "Interaction of PECAM-1 and SHP-2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49668", "l": "H(+) + NADH + O2 + protodeoxyviolaceinate = deoxyviolaceinate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004824", "l": "lysine-tRNA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44134", "l": "2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine => 2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62589", "l": "2-hydroxy-2-(4-hydroxyphenyl)acetate + H(+) => 4-hydroxybenzyl alcohol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380508", "l": "Translocation of NuMA to the centrosomes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878056", "l": "RUNX1:CBFB binds EP300 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73577", "l": "CAD hexamer transforms L-Gln to CAP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42283", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42929", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800793", "l": "PIDD1 translocates to the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665415", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.-", "l": "\"Peptidylamino-acid hydrolases or acylamino-acid hydrolases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26329", "l": "(S)-8-amino-7-oxononanoate + L-lysine = (7R,8S)-7,8-diammoniononanoate + (S)-2-amino-6-oxohexanoate"}, {"i": "EC:2.6.1.105", "l": "\"Lysine--8-amino-7-oxononanoate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66629", "l": "(2S,4S,5S)-2-amino-6-(3,4-dihydroxyphenyl)-4-hydroxy-5-(methylamino)hexanoyl-[peptidyl-carrier protein] + O2 => (2S,4S)-2-amino-4-[(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]-4-hydroxybutanoyl-[peptidyl-carrier protein] + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34798", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O <=> alpha-D-ribose 1,5-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482939", "l": "CDP-DAG is converted to PGP by PGS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67168", "l": "2-oxoglutarate + 3-hydroxy-L-phenylalanine = 3-(3-hydroxyphenyl)pyruvate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13532", "l": "(3S)-citramalate <=> H2O + mesaconate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.164", "l": "\"Galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,6-N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42778", "l": "H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine => adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19304", "l": "histamine + S-adenosyl-L-methionine <=> H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64287", "l": "2-phenylethylamine + pyruvate <=> 2-phenylacetaldehyde + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443782", "l": "CHL1 interacts with contactin-6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168849", "l": "tBID binds to inactive BAX protein (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51286", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate => (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114670", "l": "GPIb-IX-V binds to vWF:Collagen complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51854", "l": "(9Z,12Z)-octadecadienoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (9Z,12Z)-octadecadienoate(out) + ATP(in) + CoA(in) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851866", "l": "MET binds RANBP10 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19194", "l": "A + all-trans-13,14-dihydroretinol => AH2 + all-trans-retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11280", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dCMP"}, {"i": "EC:2.1.2.8", "l": "\"Deoxycytidylate 5-hydroxymethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507868", "l": "Aquaporins passively transport water into cells (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047592", "l": "5-pyridoxate dioxygenase activity"}, {"i": "KEGG.REACTION:R04570"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39493", "l": "(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+) => (2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-83788", "l": "Binding of TFIIIC to Type 2 promoter (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20056", "l": "NAD(+) + ribitol <=> D-ribulose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045237", "l": "CXCR1 chemokine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31542", "l": "(2S)-naringenin + S-adenosyl-L-methionine <=> (2S)-sakuranetin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114352", "l": "Sequestration of tBID by BCL-2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034834", "l": "2-mercaptobenzothiazole dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60149", "l": "(L-glutamyl)n-L-gamma-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate => (L-glutamyl)n+1-L-gamma-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53926", "l": "a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine => a secondary amine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042962", "l": "acridine:proton antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16566", "l": "2-oxoglutarate + L-histidine => 3-(imidazol-5-yl)pyruvate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390930", "l": "5-HT2 receptor can bind serotonin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042803", "l": "protein homodimerization activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54737", "l": "N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine => 2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14563", "l": "CoA + H(+) + N-[(E,E)-piperoyl]piperidine => (E,E)-piperoyl-CoA + piperidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380508", "l": "Translocation of NuMA to the centrosomes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696547", "l": "STAMBPL1 is a deubiquitinase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66492", "l": "GDP-alpha-D-mannose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-galctosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14513", "l": "ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate"}, {"i": "EC:6.3.5.6", "l": "\"Asparaginyl-tRNA synthase (glutamine-hydrolyzing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.1.2", "l": "\"Ferredoxin--NADP(+) reductase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017075", "l": "syntaxin-1 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63482", "l": "15-oxoprostaglandin F2alpha + H(+) + NADPH => NADP(+) + prostaglandin F2alpha"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658001", "l": "Defective LCT does not hydrolyze Lac (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48812", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22439", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005549", "l": "odorant binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682967", "l": "WHSC1 binds DNA DSBs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52303", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32588", "l": "(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 => (3R,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033286", "l": "ATPase-coupled ectoine transmembrane transporter activity"}, {"i": "RHEA:32787", "l": "ATP + H2O + L-ectoine(out) = ADP + H(+) + L-ectoine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0061665", "l": "SUMO ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50407", "l": "(2-aminobenzoyl)acetate + H(+) + S-octanoyl-L-cysteinyl-[PqsC protein] <=> 1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013143", "l": "RAC1 GEFs activate RAC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14964", "l": "H2O + S-formylglutathione <=> formate + glutathione + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32706", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> 8-hydroxycopalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30513", "l": "2-demethylmenaquinol-8 + NADP(+) => 2-demethylmenaquinone-8 + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55706", "l": "ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide => glycine + hydrogen sulfide + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57871", "l": "(E)-4-coumaroyl-CoA + 2-oxoglutarate + O2 <=> (E)-2,4-dihydroxycinnamoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29705", "l": "L-valine(out) => L-valine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-443831", "l": "14-3-3-zeta binds Raf1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396594", "l": "Phosphorylation of SLP-76 by p-SYK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53495", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) <=> 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444859", "l": "Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "80.661393760018115", "identifiers": [{"i": "GO:0047429", "l": "nucleoside-triphosphate diphosphatase activity"}, {"i": "MetaCyc:3.6.1.19-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200406", "l": "CPT1A,B transfers PALM to CAR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65686", "l": "a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontadienoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontadienoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45142", "l": "CO2 + L-glutamyl-[protein] + O2 + phylloquinol => 2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83791", "l": "Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39435", "l": "(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24569", "l": "a 6-phospho-beta-D-galactoside + H2O => an alcohol + D-galactose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26101", "l": "(2R)-homocitrate = cis-homoaconitate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66762", "l": "ADP + H(+) + kainate(out) + phosphate => ATP + H2O + kainate(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0015665", "l": "alcohol transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18039", "l": "N-carbamoylputrescine + NH4(+) => agmatine + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042293", "l": "Hub1 activating enzyme activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551727", "l": "CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26137", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56622", "l": "2,4,5-trichlorocyclohexa-2,5-dien-1-ol + chloride + H(+) => (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42388", "l": "beta-D-glucosyl crocetin + UDP-alpha-D-glucose = beta-D-gentiobiosyl crocetin + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55472", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-diene-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.68", "l": "\"Syn-pimaradiene 3-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-981539", "l": "C3b binds to cell surface (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2562526", "l": "PLK1 phosphorylates OPTN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17320", "l": "chlorophyllide a + H(+) + phytyl diphosphate <=> chlorophyll a + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37946", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64265", "l": "atrochrysone carboxylate + H(+) => atrochrysone + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3782655", "l": "HDAC10 deacetylates histone (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0106310", "l": "protein serine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52572", "l": "butanoyl-CoA + NAD(+) = (2E)-butenoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10782", "l": "3-(4-hydroxyphenyl)pyruvate + H(+) + NADH => (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204981", "l": "14-3-3epsilon attentuates NADE-related apoptosis (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13898", "l": "chorismate => prephenate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050552", "l": "(4S)-limonene synthase activity"}, {"i": "MetaCyc:4.2.3.16-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20199", "l": "[heparan-N-sulfate](n) => [heparosan-N-sulfate](n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13782", "l": "an L-alpha-amino acid + H2O + O2 => a 2-oxocarboxylate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53572", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22854", "l": "3-hydroxypyruvate + L-alanine => L-serine + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909724", "l": "Recruitment of IFNAR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "80.661393760018115", "identifiers": [{"i": "GO:0016868", "l": "intramolecular transferase activity, phosphotransferases"}, {"i": "EC:5.4.2.-", "l": "\"Phosphotransferases (phosphomutases)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174124", "l": "Dephosphorylation of phospho-Cdh1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.99", "l": "\"4-(gamma-glutamylamino)butanal dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48931", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27764", "l": "CMP + diphosphate + H(+) => CTP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912352", "l": "Galactosylation of Pre-NOTCH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168839", "l": "SHP1 (PTPN6) binds JAK2 in the receptor complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40954", "l": "(2S)-2-acetamido-4-aminobutanoate + H2O <=> acetate + L-2,4-diaminobutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47564", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GA2 (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390597", "l": "Release Of ADP From Myosin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13598", "l": "1,4-diguanidinobutane + H2O => agmatine + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39022", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53520", "l": "1-hexadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047546", "l": "2-hydroxypyridine 5-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429767", "l": "Passive I- efflux mediated by SMCT1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28969", "l": "L-proline(out) + Na(+)(out) => L-proline(in) + Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.14", "l": "\"Chitinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "64.331456145126538", "identifiers": [{"i": "GO:0015293", "l": "symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986480", "l": "IL26:IL20RA:JAK1 binds IL10RB:TYK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32386", "l": "(1S,2S,4R)-limonene-1,2-diol + NAD(+) <=> (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28626", "l": "(-)-vetispiradiene + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + solavetivol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43163", "l": "adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44577", "l": "4-hydroxy-3-all-trans-nonaprenylbenzoate + H(+) => 2-all-trans-nonaprenylphenol + CO2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050574", "l": "2-(R)-hydroxypropyl-CoM dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34309", "l": "2-hydroxy-1,4-benzoquinone + H2O + NADP(+) + nitrite => 4-nitrocatechol + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250930", "l": "B-WICH recruits histone acetyltransferases (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1067667", "l": "IL6 binds IL6R (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0004000", "l": "adenosine deaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685604", "l": "SLAMF6 binds SLAMF6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-434836", "l": "Syk/Lck phosphorylate LAT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161692", "l": "15k-PGE2/F2a is reduced to dhk-PGE2/F2a by PTGR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781953", "l": "YOD1 binds VCP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57260", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP = GDP + H(+) + lactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42839", "l": "acetyl-CoA + 7 H(+) + 5 malonyl-CoA + 3 NADPH <=> 5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 4 H2O + 3 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43832", "l": "5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA = 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54454", "l": "a uridine in tRNA + H(+) + NADH => a 5,6-dihydrouridine in tRNA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59793", "l": "H2O + NADP(+) + yersinopine => (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706308", "l": "Active FLT3 binds to GRB10 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986446", "l": "IL26 binds IL20RA:JAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392749", "l": "Transport of L1 into endosomes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036130", "l": "prostaglandin H2 endoperoxidase reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141040", "l": "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34108", "l": "glycine + H(+) + hexadecanoyl-CoA => 1-deoxymethyl-3-dehydrosphinganine + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43726", "l": "H(+) + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase] => (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050037", "l": "L-xylose 1-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13840", "l": "cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) <=> 4,5-dihydroxyphthalate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432295", "l": "GPVI binds Fyn and Lyn (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004676", "l": "3-phosphoinositide-dependent protein kinase activity"}, {"i": "REACT:R-HSA-437195", "l": "PDPK1 activates PRKCZ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35241", "l": "tetracycline(out) => tetracycline(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47309", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59755", "l": "L-lysyl-[protein] + tetradecanoyl-CoA <=> CoA + H(+) + N(6)-tetradecanoyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140769", "l": "factor VII -> factor VIIa (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55464", "l": "11-hydroxysugiol + O2 + reduced [NADPH--hemoprotein reductase] = 11,20-dihydroxysugiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204798", "l": "Interaction of Tie2 and p85 of PI3K (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29285", "l": "L-alanine(out) + Na(+)(out) => L-alanine(in) + Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35943", "l": "brevianamide F + dimethylallyl diphosphate = deoxybrevianamide E + diphosphate"}, {"i": "EC:2.5.1.109", "l": "\"Brevianamide F prenyltransferase (deoxybrevianamide E-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-434650", "l": "MATEs mediate extrusion of xenobiotics (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8939201", "l": "ESR dimerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40733", "l": "(20S)-protopanaxadiol + 2 D-glucose => (20S)-ginsenoside Rg3 + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12722", "l": "putrescine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + S-methyl-5'-thioadenosine + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044019", "l": "histone acetyltransferase activity (H3-K72 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48821", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 => 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852010", "l": "BTNL2 binds activated T cells surface (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50323", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169398", "l": "ISGylation of host protein filamin B (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18426", "l": "L-quinate + NADP(+) => 3-dehydroquinate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48749", "l": "D-threitol + NAD(+) => D-erythrulose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44140", "l": "CoA + 2 H(+) + oxidized [flavodoxin] + pyruvate = acetyl-CoA + CO2 + reduced [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168166", "l": "NFkB complex is transported from cytosol to nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56331", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + H2O <=> 5'-triphosphoadenylyl-(2'->5')-adenosine + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026411", "l": "13(R)-HDPAn-3 translocates from endothelial cell to neutrophil (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70272", "l": "PGM:Mg2+ isomerise G6P to G1P (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350186", "l": "CUBN binds GC:25(OH)D (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173740", "l": "Factor B binds to C3(H2O) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211959", "l": "CYP3A43 6b-hydroxylates TEST (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34516", "l": "tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine => N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UMP"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0072341", "l": "modified amino acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665699", "l": "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants recruit GRB2:SOS1 through SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33728", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxyhexacosanoyl)-sphinganine => a 1,2-diacyl-sn-glycerol + Ins-1-P-Cer(d18:0/2-OH-26:0)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57286", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA => a guanosine in RNA + methylglyoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35447", "l": "(1'S)-averantin + NADP(+) = H(+) + NADPH + norsolorinic acid"}, {"i": "EC:1.1.1.349", "l": "\"Norsolorinic acid ketoreductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58807", "l": "5'-pApG-3' + H2O <=> 5'-ApG-3' + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14973", "l": "L-aspartate = D-aspartate"}, {"i": "EC:5.1.1.13", "l": "\"Aspartate racemase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854052", "l": "Formation of the SCF-FBXL7 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-593685", "l": "Netrin-4 binds DCC/UNC5A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46387", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 24S,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70272", "l": "PGM:Mg2+ isomerise G6P to G1P (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853309", "l": "Autocatalytic phosphorylation of FGFR3 fusions (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072549", "l": "monocoumaroyl dicaffeoyl spermidine meta-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.36", "l": "\"Caspase-1\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51760", "l": "a 2-acyl-4,6-diprenylphloroglucinol + dimethylallyl diphosphate = a 2-acyl-4,6,6-triprenylphloroglucinol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61367", "l": "3beta-sulfooxy-androst-5-en-17-one(in) + ATP + H2O <=> 3beta-sulfooxy-androst-5-en-17-one(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34863", "l": "2,3-didehydroadipyl-CoA + H2O = 3-hydroxyadipyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029272", "l": "Release of PLCG from FCGR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32441", "l": "albaflavenone + 3 H2O + 2 NADP(+) => (+)-epi-isozizaene + 2 H(+) + 2 NADPH + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980128", "l": "NOTCH1 associates with negative regulators NUMB and ITCH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879910", "l": "JAK2 is phosphorylated, activated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38314", "l": "carminomycin + S-adenosyl-L-methionine <=> daunorubicin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48298", "l": "glycerol + H(+) + prostaglandin E2 => H2O + prostaglandin E2 1-glyceryl ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46079", "l": "(2E)-eicosenoyl-CoA + H(+) + NADH <=> eicosanoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692755", "l": "CDK1 phosphorylates MAPK6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848939", "l": "PTK6 binds KHDRBS1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30680", "l": "D-cellobiose + H2O => 2 beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047586", "l": "5'-acylphosphoadenosine hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1564169", "l": "Collagen type VIII degradation by MMP1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15772", "l": "adenosylcob(III)inamide + ATP <=> adenosylcob(III)inamide phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662773", "l": "ADAM17 binds Zn2+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46386", "l": "24S,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429699", "l": "CERT [ER] + ceramide [ER] => CERT:ceramide [ER] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418456", "l": "cGMP is degraded by PDEs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047980", "l": "hippurate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17622", "l": "acetyl-CoA + citramalate => (3S)-citramalyl-CoA + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20223", "l": "(6S)-10-formyltetrahydrofolate + ADP + phosphate => (6S)-5,6,7,8-tetrahydrofolate + ATP + formate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32546", "l": "(2E)-geranyl diphosphate + H2O <=> 1,8-cineole + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730892", "l": "Recruitment of VAV to p-SLP-76 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023941", "l": "MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25998", "l": "H2O2 + N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine => H2O + N(1)-acetylspermine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27963", "l": "myo-inositol + pyrroloquinoline quinone => H(+) + pyrroloquinoline quinol + scyllo-inosose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37783", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928620", "l": "PAK1 autophosphorylates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44659", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a monoacyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193981", "l": "CYP21A2 oxidises 17HPROG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791076", "l": "Expression of ADD1 (Adducin alpha) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851890", "l": "MET phosphorylates SHC1-2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16416", "l": "L-lysyl-[lipoyl-carrier protein] + N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] <=> (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + L-lysyl-[glycine-cleavage complex H protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14884", "l": "3-sulfanyl-2-(sulfanylmethyl)propanoate + NAD(+) <=> asparagusate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444572", "l": "Zinc is an agonist of GPR39 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694467", "l": "Spike protein forms a homotrimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16394", "l": "H2O + juvenile hormone II => H(+) + juvenile hormone II carboxylate + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655341", "l": "Activated FGFR4 mutants phosphorylate PLCG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9017797", "l": "NOTCH3 binds YBX1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176298", "l": "Activation of claspin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61971", "l": "2 [Fe(II)-cytochrome b5] + a 1-O-(9Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a 1-O-(1Z,9Z-octadecadienyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134883", "l": "Beta-catenin enhances association of IRF3 with CBP/p300  (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64431", "l": "glycyl-L-proline(out) + H(+)(out) <=> glycyl-L-proline(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60282", "l": "H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62129", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dGTP => a 2'-deoxyribonucleoside 5'-diphosphate + dGDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295613", "l": "SPRY2 binds GRB2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013021", "l": "GDIs block activation of RHOB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63013", "l": "(2E,6E)-farnesyl diphosphate + orsellinate => diphosphate + ilicicolinate B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32199", "l": "androsta-1,4-diene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.15.30", "l": "\"3-ketosteroid 9-alpha-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964280", "l": "Active Gq binds BTK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58240", "l": "H2O + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] = ADP-D-ribose + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062054", "l": "fluoride channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53615", "l": "CTP + D-ribulose 5-phosphate + H(+) <=> CDP-D-ribulose + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17131", "l": "2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate => ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53055", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate <=> 4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46712", "l": "pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683964", "l": "ATM phosphorylates EYA1-4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008520", "l": "L-ascorbate:sodium symporter activity"}, {"i": "TCDB:2.A.40.6.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33394", "l": "C20 sphinganine 1-phosphate + H2O <=> C20 sphinganine + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:1990239", "l": "steroid hormone binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939938", "l": "ESRRA:PPARG1CB binds the RUNX2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18543", "l": "dihydrochelirubine + H(+) + S-adenosyl-L-homocysteine => 10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22875", "l": "2-oxoglutarate + L-prolyl-[collagen] + O2 <=> CO2 + succinate + trans-3-hydroxy-L-prolyl-[collagen]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662096", "l": "Exocytosis of glutamate from cochlear inner hair cell (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66947", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + soppiline B <=> 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + soppiline C"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102412", "l": "valerena-4,7(11)-diene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45128", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30800", "l": "(3S)-3-hydroxybutanoyl-CoA + NAD(+) => acetoacetyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26510", "l": "H2O + L-prolinamide = L-proline + NH4(+)"}, {"i": "RHEA:26550", "l": "(S)-piperazine-2-carboxamide + H2O = (S)-piperazine-2-carboxylate + NH4(+)"}, {"i": "EC:3.5.1.101", "l": "\"L-proline amide hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66785", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(out) => 6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59763", "l": "apigenin + UDP-alpha-D-glucose <=> apigenin 7-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39248", "l": "(3R)-hydroxy-(11Z)-eicosenoyl-CoA => (2E,11Z)-eicosadienoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174097", "l": "Association of Emi1 with Cdh1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629918", "l": "NEIL1 translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687465", "l": "MRN complex binds RBBP8 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451309", "l": "Edited Kainate Receptor binds glutamate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977363", "l": "Factor H binds to C3bBb (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853800", "l": "ARTN binds RET:GFRA1,GFRA3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24286", "l": "4-phospho-L-aspartate + H(+) + NADPH => L-aspartate 4-semialdehyde + NADP(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30737", "l": "myo-inositol + phosphate => 1D-myo-inositol 4-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45536", "l": "H2O + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-octadecanoyl ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41718", "l": "a 2-acyl-sn-glycerol 3-phosphate + H(+) + L-serine => a 2-acyl-sn-glycero-3-phospho-L-serine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2559568", "l": "SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20999", "l": "(2Z,4E)-2-aminomuconate + H2O <=> (3E)-2-oxohex-3-enedioate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021520", "l": "NOTCH3 binds WWP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20126", "l": "H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] => NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5681987", "l": "LC3 is cleaved by ATG4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56835", "l": "2,6-dichlorohydroquinone + chloride + glutathione disulfide + H(+) <=> 2,3,6-trichlorohydroquinone + 2 glutathione"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990119", "l": "RNA helicase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34039", "l": "2-oxoglutarate + neamine = 6'-oxoparomamine + L-glutamate"}, {"i": "EC:2.6.1.93", "l": "\"Neamine transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657649", "l": "ALKBH2 binds alkylated DNA containing 1-etA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16172", "l": "ATP + L-glutamate + NH4(+) <=> ADP + H(+) + L-glutamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20194", "l": "(R)-mevalonate + NADP(+) => H(+) + mevaldate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20612", "l": "2-dehydro-3-deoxy-D-arabinonate <=> glycolaldehyde + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429699", "l": "CERT [ER] + ceramide [ER] => CERT:ceramide [ER] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56976", "l": "4-methylphenol + H2O + 2 oxidized [azurin] = 4-hydroxybenzyl alcohol + 2 H(+) + 2 reduced [azurin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61955", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl-[protein] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417898", "l": "P2Y4 receptor can bind to UTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48407", "l": "apo-[EntB isochorismatase/aryl-carrier protein] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[EntB isochorismatase/aryl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19544", "l": "L-glutamate 5-semialdehyde + NADP(+) + phosphate <=> H(+) + L-glutamyl 5-phosphate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109639", "l": "Formation of the closed pre-initiation complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140598", "l": "lipoprotein carrier activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44723", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O <=> a 1-acyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042380", "l": "hydroxymethylbutenyl pyrophosphate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975633", "l": "atROL binds to RBP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37845", "l": "1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102999", "l": "UDP-glucose:2-hydroxylamino-4,6-dinitrotoluene-O-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-9743"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2029454", "l": "Autophosphorylation of PAK1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13799", "l": "di-trans,poly-cis-dolichol + phosphate => dolichyl phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684096", "l": "CDK2 phosphorylates RBBP8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18175", "l": "(4-hydroxyphenyl)acetaldehyde + NH4(+) => (2R)-1-(4-hydroxyphenyl)-2-aminoethanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944247", "l": "Association of procollagen type VI (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.-", "l": "\"With other acceptors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43606", "l": "2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin] => (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53619", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-isoafricanol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35218", "l": "H2O + XDP <=> H(+) + phosphate + XMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48618", "l": "glycine + leukotriene E4 => H2O + leukotriene D4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12724", "l": "putrescine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + S-methyl-5'-thioadenosine + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52719", "l": "a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH <=> a long-chain primary fatty alcohol + CoA + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014294", "l": "RAC2 binds effectors at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388503", "l": "Oxytocin receptor bind oxytocin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788867", "l": "FN3K phosphorylates ketosamines (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39646", "l": "(2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H(+) + NADPH <=> (18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801776", "l": "REG3A binds bacterial phospholipids (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62080", "l": "D-glucose 6-sulfate + NADP(+) = 6-sulfo-D-glucono-1,5-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.94", "l": "\"Ethylmalonyl-CoA decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30230", "l": "2 [Fe(III)-cytochrome c2] + dimethyl sulfide + H2O <=> 2 [Fe(II)-cytochrome c2] + dimethyl sulfoxide + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201634", "l": "Caspase-mediated cleavage of FADK 1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.n4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22485", "l": "H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate => GMP + GTP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372542", "l": "Loading of dopamine into synaptic veiscles (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4332235", "l": "CBL binds TGFBR2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54726", "l": "3 H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine => N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050410", "l": "3-oxolaurate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42416", "l": "a ubiquinone + L-proline = (S)-1-pyrroline-5-carboxylate + a ubiquinol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791169", "l": "Expression of WFS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14935", "l": "N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate => H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11740", "l": "2 glutathione + NADP(+) = glutathione disulfide + H(+) + NADPH"}, {"i": "EC:1.8.1.7", "l": "\"Glutathione-disulfide reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27436", "l": "2 glutathione amide + NAD(+) <=> glutathione amide disulfide + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68914", "l": "DNA polymerase alpha:primase binds at the origin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070119", "l": "ciliary neurotrophic factor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951644", "l": "Release of mature NEDD8 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52495", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25762", "l": "ent-copalyl diphosphate <=> diphosphate + ent-isokaurene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36841", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13194", "l": "5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) => 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17849", "l": "(3R)-3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O"}, {"i": "EC:4.2.1.55", "l": "\"3-hydroxybutyryl-CoA dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944236", "l": "Association of procollagen type XIV (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28310", "l": "beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)"}, {"i": "EC:2.4.1.252", "l": "\"GDP-mannose:cellobiosyl-diphosphopolyprenol alpha-mannosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1614614", "l": "Cysteine is degraded to serine and H2S (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018492", "l": "carbon-monoxide dehydrogenase (acceptor) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57348", "l": "3-hydroxy-4-methyl-L-kynurenine + H2O = 3-hydroxy-4-methylanthranilate + H(+) + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32473", "l": "(7S)-marmesin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => demethylsuberosin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800490", "l": "ATM phosphorylates PIDD1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847537", "l": "RAB43:GTP binds USP8NL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033449", "l": "GUU codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9011983", "l": "Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24843", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine <=> 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854736", "l": "FLT3LG dimer:FLT3 binds FLT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16434", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17470", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester + apo--[retinol-binding protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084507", "l": "Laminin-111 binds endostatin dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12489", "l": "2-amino-2-deoxy-D-gluconate => 2-dehydro-3-deoxy-D-gluconate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19456", "l": "2-oxoglutarate + L-alanine <=> L-glutamate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975852", "l": "IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017134", "l": "fibroblast growth factor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332236", "l": "CBL neddylates TGFBR2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031836", "l": "neuromedin K receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66739", "l": "ATP + beta-citrylglutamate(in) + H2O <=> ADP + beta-citrylglutamate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20741", "l": "H2O + trans-2,3-epoxysuccinate => (2R,3S)-tartrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13083", "l": "biotin + NH4(+) => biotin amide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21838", "l": "2-dehydro-3-deoxy-D-arabinonate + H2O => D-arabinonate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080049", "l": "L-gulono-1,4-lactone dehydrogenase activity"}, {"i": "MetaCyc:RXN-1439"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6794347", "l": "Homer1,2,3 dimerizes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62486", "l": "2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30659", "l": "4-(phosphooxy)-L-threonine + H2O = 4-hydroxy-L-threonine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25427", "l": "diphosphate + GMP <=> 5-phospho-alpha-D-ribose 1-diphosphate + guanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2995330", "l": "COX10 transforms heme to heme O (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12635", "l": "(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+) => benzoate + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944220", "l": "Association of procollagen type XXIII (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102128", "l": "chalcone synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34177", "l": "4-hydroxycoumarin + CO2 + 2 CoA => 2-hydroxybenzoyl-CoA + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44598", "l": "a fatty acid + H(+) + holo-[ACP] => a fatty acyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52961", "l": "hyocholate + UDP-alpha-D-glucuronate => hyocholoyl-24-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15892", "l": "H2O + L-glutamine <=> L-glutamate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56386", "l": "(5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24862", "l": "pelargonidin 3-O-rutinoside + UDP-alpha-D-glucose => H(+) + pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665416", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863494", "l": "ASICs bind STOML3, (STOM) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048487", "l": "beta-tubulin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11103", "l": "4-hydroxyhexan-3-one <=> 2 propanal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141341", "l": "SMOX-3 oxidises SPN to SPM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029460", "l": "PAK1 phosphorylates LIMK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42009", "l": "5alpha-pregnan-20beta-ol-3-one + NAD(+) => 5alpha-pregnane-3,20-dione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25832", "l": "1D-chiro-inositol + NAD(+) = H(+) + NADH + scyllo-inosine"}, {"i": "EC:1.1.1.369", "l": "\"D-chiro-inositol 1-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-170149", "l": "Translocation of active Cdc25C to the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17905", "l": "(R)-glycerate + NAD(+) = 3-hydroxypyruvate + H(+) + NADH"}, {"i": "RHEA:18657", "l": "(R)-glycerate + NADP(+) = 3-hydroxypyruvate + H(+) + NADPH"}, {"i": "EC:1.1.1.29", "l": "\"Glycerate dehydrogenase\""}, {"i": "EC:1.1.1.81", "l": "\"Hydroxypyruvate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21238", "l": "2,3-dihydroxybenzoate + NADP(+) + NH4(+) => anthranilate + 2 H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21588", "l": "N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH"}, {"i": "EC:1.2.1.38", "l": "\"N-acetyl-gamma-glutamyl-phosphate reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25920", "l": "A + H2O + quinolin-7-ol = 7-hydroxyquinolin-2(1H)-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23128", "l": "4-hydroxybutanoate + ATP + CoA = 4-hydroxybutanoyl-CoA + AMP + diphosphate"}, {"i": "EC:6.2.1.40", "l": "\"4-hydroxybutyrate--CoA ligase (AMP-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29566", "l": "ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799350", "l": "Exocytosis of specific granule membrane proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.7.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20413", "l": "glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine = glucuronoxylan 4-O-methyl-D-glucuronate + n H(+) + n S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.112", "l": "\"Glucuronoxylan 4-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174456", "l": "Joining of adjacent Okazaki fragments of the C-strand (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13816", "l": "benzene + H(+) + NADH + O2 <=> cis-1,2-dihydrobenzene-1,2-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58068", "l": "O2 + trans-isoeugenol = acetaldehyde + vanillin"}, {"i": "EC:1.13.11.88", "l": "\"Isoeugenol monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9611839", "l": "β3-agonists bind ADRB3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10426", "l": "benzoate + glycine => H2O + N-benzoylglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46633", "l": "7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + NADPH => 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29954", "l": "H(+)(in) + uridine(in) <=> H(+)(out) + uridine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009558", "l": "IL34 dimer binds SDC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58715", "l": "NADH + O2 + rifampicin <=> H(+) + H2O + NAD(+) + rifampicin para-naphthoquinone carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173647", "l": "Transport of trimeric gp41:gp120 to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28579", "l": "Co(2+)(in) => Co(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32245", "l": "D-ribulose 1,5-bisphosphate => alpha-D-ribose 1,5-bisphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051753", "l": "mannan synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49334", "l": "2,2-dihydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-hydroxyspheroidene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44958", "l": "hexanoyl-CoA + NADP(+) => (2E)-hexenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53667", "l": "(2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + NH4(+) <=> H(+) + 2 H2O + pyridinestrone carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34333", "l": "(indol-3-yl)acetate + CO2 + H2O + NADP(+) => H(+) + indole-3-pyruvate + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23724", "l": "H2O + O2 + pyridoxal = 4-pyridoxate + H(+) + H2O2"}, {"i": "EC:1.2.3.8", "l": "\"Pyridoxal oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66364", "l": "(3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H2O = 6-methyl-3,7-dioxodecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73806", "l": "AIR + CO2 => CAIR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27860", "l": "3'-GMP + H(+) => 2',3'-cyclic GMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247836", "l": "Retromer recycles WLS to the Golgi (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964465", "l": "DREAM complex binds the PCNA gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112395", "l": "Abortive termination of elongation after arrest (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62789", "l": "2 fonsecin B + H(+) + NADPH + O2 => aurasperone B + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689972", "l": "USP2 deubiquitinates MDM2,MDM4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47030", "l": "[DsrC protein]-disulfide + H(+) + sulfite => [DsrC protein]-S-sulfo-L-cysteine/L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11607", "l": "[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA <=> [(2->8)-O(7),N-diacetyl-alpha-D-neuraminosyl](n) + n CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428750", "l": "Gq activation by TP receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9661425", "l": "BIL:ALB dissociates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54529", "l": "aldehydo-D-ribose 5-phosphate => D-ribose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730886", "l": "Phosphorylation of SHC by SYK kinase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19302", "l": "histamine + S-adenosyl-L-methionine => H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23810", "l": "(S)-tetrahydrocolumbamine + H(+) + S-adenosyl-L-homocysteine => (S)-scoulerine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61457", "l": "7-chlorotetracycline + H(+) + NADPH + O2 => (1S,10S,10aS)-3-(CONH2)-9-Cl-1-(Me2N)-3,3a,4,10-(HO)4-10-Me-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracen-6-olate + CO + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5603467", "l": "Activated protein C is released from PROCR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25667", "l": "(2E)-geranyl diphosphate => beta-pinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41050", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol <=> 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694794", "l": "mRNA3 is translated to protein 3a (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24218", "l": "(2E,6E)-farnesoate + 2 H(+) + NADH => (2E,6E)-farnesal + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21993", "l": "acetyl-CoA + L-lysyl-[histone] => CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24665", "l": "2 N(omega)-hydroxy-L-arginine + NADPH + 2 O2 => H(+) + 2 H2O + 2 L-citrulline + NADP(+) + 2 nitric oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-561072", "l": "OCT3 mediates renal uptake of organic cations (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043757", "l": "adenosylcobinamide-phosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196857", "l": "PANK2 phosphorylates PanK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004782", "l": "sulfinoalanine decarboxylase activity"}, {"i": "RHEA:16877", "l": "3-sulfino-L-alanine + H(+) = CO2 + hypotaurine"}, {"i": "RHEA:25221", "l": "H(+) + L-cysteate = CO2 + taurine"}, {"i": "EC:4.1.1.29", "l": "\"Sulfinoalanine decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696997", "l": "USP24 deubiquitinates DDB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632412", "l": "PTK2 is recruited to methylated ESR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62690", "l": "2 H2O + 2 ustilaginoidin A => 4 norrubrofusarin + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168326", "l": "Assembly of an Active Transcription Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54150", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene + H2O => 1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49850", "l": "(-)-dehydrodiconiferyl acid carboxylate + a quinol + H(+) => (-)-dehydrodiconiferyl acid ketone + a quinone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20014", "l": "carbamoyl phosphate + L-aspartate => H(+) + N-carbamoyl-L-aspartate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39413", "l": "(2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33994", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-copaene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51326", "l": "(8R)-hydroperoxy-(9E,11Z,14Z)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40812", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11816", "l": "aldehydo-D-glucose 6-phosphate = keto-D-fructose 6-phosphate"}, {"i": "EC:5.3.1.9", "l": "\"Glucose-6-phosphate isomerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-912734", "l": "CBL:CRKL binds RAPGEF1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10080", "l": "dihydrophloroglucinol + NADP(+) = 1,3,5-trihydroxybenzene + NADPH"}, {"i": "EC:1.3.1.57", "l": "\"Phloroglucinol reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201630", "l": "Caspase-mediated cleavage of Acinus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630053", "l": "NTHL1 D239Y does not cleave thymine glycol (Tg) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60915", "l": "cytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-methionine <=> H(+) + N(3)-methylcytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671972", "l": "CIT binds CDKN1B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46782", "l": "a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11473", "l": "an N-methyl-L-amino acid + H2O + O2 => an L-alpha-amino acid + formaldehyde + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45727", "l": "(E)-4-coumaroyl alcohol + NADP(+) <=> (E)-4-coumaraldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33570", "l": "A + ethanol <=> acetaldehyde + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65272", "l": "chrodrimanin C + H(+) + NADPH + O2 = chrodrimanin H + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975040", "l": "KRAB-ZNF / KAP Interaction (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21523", "l": "2 [Fe(III)-cytochrome b1] + formate <=> 2 [Fe(II)-cytochrome b1] + CO2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004477", "l": "methenyltetrahydrofolate cyclohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59732", "l": "biotinyl-5'-AMP + L-lysyl-[protein] = AMP + 2 H(+) + N(6)-biotinyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3321975", "l": "NuA4 complex acetylates histone H2A, HIST1H4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4411373", "l": "NLK translocates to nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60706", "l": "a 1-acyl-sn-glycero-2,3-cyclic phosphate + ethanolamine => a 1-acyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24084", "l": "all-trans-zeaxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = all-trans-antheraxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863008", "l": "Calpain activation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11437", "l": "4 [Fe(II)cytochrome c] + 4 H(+) + O2 => 4 [Fe(III)cytochrome c] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.1", "l": "\"Microtubule-severing ATPase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14792", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine <=> a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59443", "l": "(-)-dehydrodiconiferyl alcohol + H(+) + NADPH <=> (S)-isodihydrodehydrodiconiferyl alcohol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30849", "l": "(2E)-butenoyl-CoA + CO2 + FADH2 => FAD + glutaryl-CoA + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14886", "l": "H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] => ADP-D-ribose + L-arginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450533", "l": "PKCdelta phosphorylates HuR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33256", "l": "2-demethylmenaquinol-7 + S-adenosyl-L-methionine => H(+) + menaquinol-7 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20350", "l": "H(+) + NADH + O2 + toluene => 2-hydroxytoluene + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-398184", "l": "LARG activation by G alpha 12/13 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30038", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADH + O2 <=> benzene-1,2,4-triol + CO2 + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62340", "l": "(+)-premalbrancheamide + bromide + FAD + 2 H(+) = (+)-malbrancheamide C + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61914", "l": "ADP + H(+) + phosphate + voriconazole(out) => ATP + H2O + voriconazole(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28361", "l": "FAD + H(+) + tetradecanoyl-CoA <=> (2E)-tetradecenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102464", "l": "zeaxanthin 2-beta-hydroxylase activity"}, {"i": "MetaCyc:RXN-14016"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42488", "l": "(3R)-3-amino-3-phenylpropanoyl-CoA + baccatin III = 3'-N-debenzoyl-2'-deoxytaxol + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004730", "l": "pseudouridylate synthase activity"}, {"i": "RHEA:18337", "l": "D-ribose 5-phosphate + uracil = H2O + psi-UMP"}, {"i": "EC:4.2.1.70", "l": "\"Pseudouridylate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0002060", "l": "purine nucleobase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68954", "l": "Mcm2-7 is phosphorylated by DDK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693978", "l": "Small molecule inhibitor binds RIPK1, RIPK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875558", "l": "RAPGEF1 binds CRK,CRKL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382056", "l": "Crk binds to the active PDGF receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449117", "l": "TXLNA (IL14) binds syntaxin1A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60456", "l": "ATP + UTP = 3',3'-cUAMP + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878654", "l": "ACP6 hydrolyses MYS-LPA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14380", "l": "(3R)-3-hydroxy-L-aspartate <=> glycine + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928656", "l": "gamma-secretase cleaves EPHB2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203130", "l": "OLR1 binds to oxidized LDL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55741", "l": "H2O + oleuropein => D-glucose + oleuropein aglycone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372542", "l": "Loading of dopamine into synaptic veiscles (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10606", "l": "a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202727", "l": "Integrin alphaMbeta2 (MAC1) binds JAM3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015492", "l": "phenylalanine:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26216", "l": "9alpha-copalyl diphosphate + H2O <=> aphidicolan-16beta-ol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19957", "l": "2 5'-dehydroinosine + O2 = 2 9-riburonosylhypoxanthine + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11764", "l": "H2O + methylguanidine = methylamine + urea"}, {"i": "EC:3.5.3.16", "l": "\"Methylguanidinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61686", "l": "glycerol + H(+) + phosphocholine => glycero-2-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694492", "l": "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696960", "l": "USP49 deubiquitinates H2B (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061507", "l": "2',3'-cyclic GMP-AMP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48629", "l": "a ribonucleotide in rRNA + S-adenosyl-L-methionine => a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71849", "l": "LDH tetramer reduces PYR to LACT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35560", "l": "H(+) + menaquinone-7 + NADH => menaquinol-7 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102473", "l": "eriodictyol dibenzoylmethane tautomer 8C-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-14079"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36380", "l": "4alpha-methyl-5alpha-cholesta-8,24-dien-3-one + H(+) + NADPH => 4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39145", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADH => (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672176", "l": "STAT binds to the mutant PDGFRA receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13036", "l": "aldehydo-D-galactose 6-phosphate <=> keto-D-tagatose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034280", "l": "ent-sandaracopimaradiene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2533874", "l": "Laminin-511 degradation by MMP14 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51141", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + 2 O2 => (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E)-docosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42981", "l": "L-tyrosine => 2-aminoprop-2-enoate + phenol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009671", "l": "nitrate:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5444516", "l": "Formation of MSH2:MSH6 Complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55605", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-acyl-sphingoid base => a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-acylsphingoid base"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047760", "l": "butyrate-CoA ligase activity"}, {"i": "RHEA:48340", "l": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate"}, {"i": "EC:6.2.1.2", "l": "\"Medium-chain acyl-CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51311", "l": "H(+) + L-methionyl-[F-actin] + NADPH + O2 <=> H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3769394", "l": "AKT phosphorylates CBY1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197963", "l": "DHFR2 reduces FOLA to DHF (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45769", "l": "gamma-glutamyl-L-alaninol + H2O => L-alaninol + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483089", "l": "PE is converted to PS by PTDSS2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18448", "l": "H2O + IMP <=> 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37083", "l": "[sulfur carrier]-SH + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + S-adenosyl-L-methionine = [sulfur carrier]-H + H(+) + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45347", "l": "globoside NOR1 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> globoside NORint (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.n4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14468", "l": "H2O + L-histidinol phosphate <=> L-histidinol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24320", "l": "an L-polyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = an L-N-hydroxypolyhomomethionine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655269", "l": "Activated FGFR1 mutants bind FRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9640167", "l": "RRAGA,B exchanges GDP for GTP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106306", "l": "protein serine phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-947531", "l": "Molybdenum ion transfer onto molybdopterin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41702", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + glutarate + H(+) => 1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865320", "l": "CBFB binds RUNX1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40165", "l": "(R)-glycerate + 2 H(+) + NADPH => D-glyceraldehyde + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42827", "l": "2 H(+) + 2 NADH + 2 O2 + tetracenomycin A2 <=> H2O + 2 NAD(+) + tetracenomycin C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391939", "l": "TP receptor can bind thromboxane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53543", "l": "(13R)-S-cysteinylglycinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O <=> (13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70494", "l": "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047698", "l": "beta-alanyl-CoA ammonia-lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38306", "l": "2-amino-2-deoxy-D-gluconate 6-phosphate <=> 2-dehydro-3-deoxy-6-phospho-D-gluconate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28959", "l": "D-xylose(in) + H(+)(in) = D-xylose(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21289", "l": "D-glucose + sn-glycerol 3-phosphate => D-glucose 6-phosphate + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18348", "l": "a cis-3-alkyl-4-alkyloxetan-2-one <=> a cis-alkene + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937177", "l": "AHR:TCDD binds ARNT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70501", "l": "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21406", "l": "chlorite => chloride + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928616", "l": "Activated ROCK phosphorylates MRLCs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39907", "l": "2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose = dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + L-glutamate"}, {"i": "EC:2.6.1.106", "l": "\"dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.69", "l": "\"GDP-L-galactose/GDP-D-glucose: hexose 1-phosphate guanylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49949", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2 => (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9681616", "l": "AP2 binds chlorpromazine (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5671737", "l": "p-T774-PKN1 binds CDC25C (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5669158", "l": "NF2 binds PAK1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626060", "l": "HSPA8:Substrate dissociates from LAMP2a multimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390593", "l": "ATP Hydrolysis By Myosin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34699", "l": "(2E,6E)-farnesyl diphosphate = (-)-alpha-isocomene + diphosphate"}, {"i": "EC:4.2.3.136", "l": "\"Alpha-isocomene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687625", "l": "ATP binds MLKL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28664", "l": "H2O + melibiose => alpha-D-galactose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14800", "l": "2-dehydro-3-deoxy-D-gluconate + ATP <=> 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11505", "l": "6-demethylsterigmatocystin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + sterigmatocystin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451418", "l": "Pellino ubiquitinates IRAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814409", "l": "CK2 phosphorylates PDCL (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022065", "l": "DSPGs are secreted (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635102", "l": "GPR161 is internalized (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21133", "l": "H2O + O2 + xanthine => H2O2 + urate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65126", "l": "benzyl acetate + CoA => benzoyl-CoA + ethanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174202", "l": "Degradation of multiubiquitinated Securin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592240", "l": "Formation of NRF2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68615", "l": "Formation of ORC(1-6) complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38865", "l": "alpha-D-glucose 1-phosphate + beta-D-fructose 6-phosphate => phosphate + sucrose 6(F)-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177923", "l": "Sustained activation of SRC kinase by SHP2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44830", "l": "CoA + O-decanoyl-(R)-carnitine => (R)-carnitine + decanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36694", "l": "octadecanoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-octadecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61627", "l": "2-oxoglutarate + cadaverine <=> 5-aminopentanal + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052612", "l": "adonirubin 3-hydroxylase activity"}, {"i": "MetaCyc:RXN-8187"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16053", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosamine = H(+) + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP"}, {"i": "EC:2.4.1.187", "l": "\"N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13776", "l": "(S)-cheilanthifoline + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-stylopine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48005", "l": "1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 => 3,4-dimethoxybenzaldehyde + glycolaldehyde + guaiacol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050390", "l": "valine decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157640", "l": "NEXT2 is cleaved to produce NICD2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52663", "l": "an L-alpha-amino acid + ATP + holo-[ACP] <=> AMP + an L-alpha-aminoacyl-[ACP] + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52725", "l": "3'-phosphoadenylyl sulfate + an aliphatic desulfo-glucosinolate => adenosine 3',5'-bisphosphate + an omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8932334", "l": "KEAP1:CUL3:RBX1:NFE2L2 dissociates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27618", "l": "(2Z,6E)-farnesyl diphosphate + 11 isopentenyl diphosphate = di-trans,undeca-cis-tetradecaprenyl diphosphate + 11 diphosphate"}, {"i": "EC:2.5.1.88", "l": "\"Trans,polycis-polyprenyl diphosphate synthase ((2Z,6E)-farnesyl diphosphate specific)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13636", "l": "ATP + L-glutamate + putrescine <=> ADP + gamma-L-glutamylputrescine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50516", "l": "acetyl-CoA + N-terminal L-threonyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222093", "l": "BRD7 binds TP53 and EP300 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38303", "l": "2-amino-2-deoxy-D-gluconate 6-phosphate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + NH4(+)"}, {"i": "EC:4.3.1.29", "l": "\"D-glucosaminate-6-phosphate ammonia lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15548", "l": "(3S)-citramalate <=> acetate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55740", "l": "H2O + oleuropein = D-glucose + oleuropein aglycone"}, {"i": "EC:3.2.1.206", "l": "\"Oleuropein beta-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41950", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH => [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39052", "l": "ATP + cholesterol(in) + H2O => ADP + cholesterol(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003850", "l": "2-deoxyglucose-6-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45771", "l": "gamma-glutamyl-L-alaninol + H2O <=> L-alaninol + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168883", "l": "Haptoglobin:Hemoglobin binds CD163 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21953", "l": "5alpha-pregnane-3,20-dione + NADP(+) => H(+) + NADPH + progesterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696274", "l": "RND1 binds GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016656", "l": "monodehydroascorbate reductase (NADH) activity"}, {"i": "MetaCyc:1.6.5.4-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673794", "l": "ppDVL:RAC1:GTP binds NOX1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38399", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O = (9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22146", "l": "D-threo-isocitrate => cis-aconitate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37203", "l": "(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811427", "l": "COPI vesicle uncoating at the ER (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8962050", "l": "TYMS gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3772430", "l": "CTNNBIP1 binds beta-catenin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40080", "l": "docosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159826", "l": "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972960", "l": "POU5F1 (OCT4), SOX2, NANOG bind the FGF2 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032406", "l": "MutLbeta complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49374", "l": "H2O + NAD(+) + protoviolaceinate => H(+) + NADH + O2 + protodeoxyviolaceinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161792", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423632", "l": "AFXBO binds DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23287", "l": "isopentenyl diphosphate <=> dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36212", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + H2O => 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17770", "l": "choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12217", "l": "9H-fluoren-9-ol + NAD(+) => 9H-fluoren-9-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47959", "l": "3-maleylpyruvate + H2O <=> H(+) + maleate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35085", "l": "acetate + N'-monoacetylchitobiose-6'-phosphate => diacetylchitobiose-6'-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417829", "l": "P2RY12 binds ADP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31450", "l": "6-amino-2-oxohexanoate + H2O2 <=> 5-aminopentanoate + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65954", "l": "2 a 1,4-benzosemiquinone + NAD(+) => 2 a quinone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42568", "l": "2,3-dihydroxy-p-cumate + O2 = 3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189488", "l": "UROS transforms HMB to URO3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21665", "l": "4-nitrophenyl phosphate + H2O => 4-nitrophenol + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65134", "l": "CO2 + H2O + preaustinoid A2 + succinate => 2-oxoglutarate + O2 + preaustinoid A1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730858", "l": "Autophosphorylation of BTK/ITK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27912", "l": "2-dehydro-D-gluconate + H(+) + NADH => D-gluconate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693148", "l": "BCKDK phosphorylates BCKDH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418200", "l": "SRC-1 bound to ARRB2 is not activated (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38618", "l": "cyclic ADP-ribose + H2O <=> ADP-D-ribose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13424", "l": "an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate <=> an N-acylneuraminate 9-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61617", "l": "H(+) + L-proline betaine + NADH + O2 => formaldehyde + H2O + N-methyl-L-proline + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18991", "l": "2-methylpropan-1-amine + CO2 => H(+) + L-valine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649701", "l": "NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933539", "l": "Recruitment of IKK complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40876", "l": "(9Z,12Z)-octadecadienoyl-CoA + FAD + H(+) => (2E,9Z,12Z)-octadecatrienoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097643", "l": "amylin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166038", "l": "GPI-bound CD14 binds LPS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63064", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA = 3 CO2 + 4 CoA + tetraacetate lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22687", "l": "4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2 <=> (2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52256", "l": "a 7(1)-hydroxybacteriochlorophyllide c + H2O + S-adenosyl-L-methionine = 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide c + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14556", "l": "(7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate <=> 2-oxoglutarate + cephalosporin C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374663", "l": "DCC interaction with Ezrin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39579", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA = (2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016161", "l": "beta-amylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37639", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004902", "l": "granulocyte colony-stimulating factor receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38393", "l": "(9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4341073", "l": "PIAS3 SUMOylates PGR with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16601", "l": "L-aspartate = fumarate + NH4(+)"}, {"i": "EC:4.3.1.1", "l": "\"Aspartate ammonia-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61382", "l": "2,4-dinitrophenyl-S-glutathione(out) + ADP + H(+) + phosphate => 2,4-dinitrophenyl-S-glutathione(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46303", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 2-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16253", "l": "(3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) = H(+) + NADH + phenanthrene-3,4-diol"}, {"i": "EC:1.3.1.49", "l": "\"Cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39383", "l": "3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202291", "l": "Activation of Lck (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51168", "l": "(R)-adrenaline + H2O + O2 = 3,4-dihydroxymandelaldehyde + H2O2 + methylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.n3", "l": "\"Ceramide phosphoethanolamine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48941", "l": "an L-aminoacyl-L-amino acid + H2O => 2 an L-alpha-amino acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090524", "l": "cytochrome-b5 reductase activity, acting on NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39432", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19572", "l": "5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine <=> 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51341", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => 10-hydroperoxy-(4Z,7Z,11E,13Z,16Z,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021182", "l": "MECP2 mRNA binds miR-132 RISC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211874", "l": "CYP2S1 4-hydroxylates atRA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56093", "l": "bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) => biliverdin IXalpha + reduced coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52084", "l": "13-octadecanoyloxy-octadecanoate + H2O = 13-hydroxy-octadecanoate + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60751", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-pyrethrolone <=> CoA + pyrethrin II"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706344", "l": "FLT3 phosphorylates GRB10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39265", "l": "(13Z)-docosenoyl-CoA + NADP(+) => (2E,13Z)-docosadienoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804099", "l": "HMGB1 binds LTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031218", "l": "arabinogalactan endo-1,4-beta-galactosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65934", "l": "3,5-dimethyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + H(+) + S-adenosyl-L-homocysteine => 3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030353", "l": "fibroblast growth factor receptor antagonist activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45879", "l": "2-methylhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 6-(hexadecan-2-yl)-4-hydroxy-pyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25046", "l": "(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426032", "l": "DAG is metabolized by DAGL to 2-AG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35334", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17779", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+) => a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975866", "l": "MyD88 forms a complex with the activated TLR receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65437", "l": "a 5'-end triphospho-adenylyl-adenylyl-cytidyl-adenosine in mRNA + GDP + H(+) => a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidyl-adenosine in mRNA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389841", "l": "MTFMT formylates methionyl-tRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17654", "l": "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676595", "l": "TRAFs bind RANK:RANKL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58129", "l": "A + O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine => AH2 + alstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694583", "l": "ABHD4 hydrolyses NAPE (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192627", "l": "Viral mRNA Export (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977619", "l": "CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61530", "l": "a diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27810", "l": "dimethylallyl diphosphate + 2 isopentenyl diphosphate = (2Z,6Z)-farnesyl diphosphate + 2 diphosphate"}, {"i": "EC:2.5.1.92", "l": "\"(2Z,6Z)-farnesyl diphosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2247513", "l": "STAB1:ligand is endocytosed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18558", "l": "1-O-alkyl-sn-glycero-3-phosphate + acetyl-CoA => 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389352", "l": "Translocation of Vav1 to CD28 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004556", "l": "alpha-amylase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043914", "l": "NADPH:sulfur oxidoreductase activity"}, {"i": "EC:1.8.1.18", "l": "\"NAD(P)H sulfur oxidoreductase (CoA-dependent)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35112", "l": "2-dehydro-L-idonate + NADP(+) => 2,5-didehydro-D-gluconate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033429", "l": "CGU codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17864", "l": "21-hydroxyprogesterone <=> 20-hydroxy-3-oxopregn-4-en-21-al"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2574845", "l": "AJUBA binds centrosome-associated AURKA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052911", "l": "23S rRNA (guanine(745)-N(1))-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21733", "l": "chorismate + L-glutamine => anthranilate + H(+) + L-glutamate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-139941", "l": "Binding of IP3 to IP3 receptor (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64654", "l": "(E)-4-coumaroyl-CoA + H(+) + NADPH => (E)-4-coumaraldehyde + CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130151", "l": "Dimerization of DAP12 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51428", "l": "acetyl-CoA + aminomethylphosphonate = 2-N-acetamidomethylphosphonate + CoA"}, {"i": "RHEA:58052", "l": "(2-aminoethyl)phosphonate + acetyl-CoA = (2-acetamidoethyl)phosphonate + CoA + H(+)"}, {"i": "EC:2.3.1.280", "l": "\"(Aminoalkyl)phosphonate N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008773", "l": "[protein-PII] uridylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621042", "l": "TF gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62430", "l": "3,4-dihydroxybenzaldehyde + acetyl-CoA => 3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33542", "l": "ergosteryl ester + H2O <=> a carboxylate + ergosterol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21162", "l": "ATP + citrate + CoA => acetyl-CoA + ADP + oxaloacetate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852324", "l": "GTSE1 binds PLK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59766", "l": "CoA + H(+) + N(6)-octadecanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] => L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354077", "l": "Integrin alphaIIb beta3 activation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647980", "l": "mature RAS proteins translocate to plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033435", "l": "AUA codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879293", "l": "formylmycothiol hydrolyzes into mycothiol and formate (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29628", "l": "alpha-maltohexaose + beta-maltose => alpha-maltoheptaose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57015", "l": "a menaquinone + H2O + sulfite <=> a menaquinol + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863718", "l": "AGFG1 binds VAMP7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58376", "l": "decan-1-ol + NADP(+) = decanal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8934446", "l": "Activated PKC phosphorylates SHC1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168166", "l": "NFkB complex is transported from cytosol to nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604763", "l": "Autocatalytic activation of MMP7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48070", "l": "ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate => ganglioside GM2 (d18:1(4E)) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862771", "l": "PLA2G2A binds bacterial phospholipids (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35011", "l": "D-fucose(in) + H(+)(in) = D-fucose(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.39"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30149", "l": "FAD + 2 H(+) + NADH => FADH2 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388808", "l": "CD28 homodimer binds B7-2 monomer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16495", "l": "glycerol 1-phosphate + H(+) => glycerol 1,2-cyclic phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14047", "l": "3-(hydrohydroxyphosphoryl)pyruvate + CO2 => 1-carboxyvinyl carboxyphosphonate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033741", "l": "adenylyl-sulfate reductase (glutathione) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876446", "l": "p-ULK1 phosphorylates DENND3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654651", "l": "Activated FGFR4 binds FRS3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63209", "l": "5-amino-6-(D-ribitylamino)uracil + glyoxal => 5-(2-oxoethylideneamino)-6-(D-ribitylamino)uracil + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0120017", "l": "ceramide transfer activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429730", "l": "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76416", "l": "Benzene is hydroxylated to phenol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632412", "l": "PTK2 is recruited to methylated ESR1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63677", "l": "CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+) => (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632766", "l": "TP53 stimulates SCO2 gene transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-418456", "l": "cGMP is degraded by PDEs (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701507", "l": "PTPN6 dephosphorylates JAK3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40782", "l": "2-aminopentanenitrile + H(+) + 2 H2O <=> L-2-aminopentanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30573", "l": "6 AMP + 6 diphosphate + enterobactin + 4 H(+) => 3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088205", "l": "Plasma membrane glycoconjugates translocate to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19267", "l": "3-dehydrocarnitine + H(+) + NADH => carnitine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28389", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine <=> di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53287", "l": "NAD(+) + scyllo-inosose <=> 3-dehydro-scyllo-inosose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47603", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate <=> CMP + ganglioside GM4 (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200143", "l": "AKT phosphorylates AKT1S1 (PRAS40) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38444", "l": "a long chain fatty alcohol + an acyl-CoA => a wax ester + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69053", "l": "RFC binding displaces Pol Alpha (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6795473", "l": "PDPK1 phosphorylates SGK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52875", "l": "17alpha-estradiol + UDP-alpha-D-glucuronate <=> 17alpha-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632871", "l": "Defective SLC2A10 does not transport Glc from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24200", "l": "4-aminobenzoate + H(+) = aniline + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23006", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + H(+) + UDP => a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68849", "l": "Mcm2-7 associates with the Cdt1:CDC6:ORC:origin complex, forming the pre-replicative complex (preRC) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25683", "l": "L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865605", "l": "BRWD1 binds SMARCA4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051432", "l": "BH1 domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26165", "l": "AH2 + echinenone + O2 => 4'-hydroxyechinenone + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37556", "l": "D-kanosamine 6-phosphate + H2O => kanosamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247840", "l": "WLS binds WNT ligands in the Golgi (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18171", "l": "glyoxylate + pyruvate => 4-hydroxy-2-oxoglutarate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902249", "l": "IMP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31981", "l": "H2O + NADP(+) + trimethylamine N-oxide => NADPH + O2 + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912389", "l": "Formation of axial/lateral elements of Synaptonemal Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170120", "l": "Translocation of Cdc25B to the cytoplasm (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804955", "l": "ATM phosphorylates MDM2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41728", "l": "(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0004467", "l": "long-chain fatty acid-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047794", "l": "cyclohexadienyl dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66318", "l": "alpha-D-mannosyl-di-(inositol-1-phosphate) + an N-acyl-(4R)-4-hydroxysphinganine + H(+) => an inositol phosphomannosyl-alpha-1->6-inositol-1-phospho-N-acyl-4R-hydroxysphinganine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685208", "l": "CCDC59:TTF1 binds SFTPB gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45901", "l": "a (3Z)-enoyl-CoA => a 4-saturated (2E)-enoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5223313", "l": "ABCD4:LMBRD1 transports Cbl from lysosomal lumen to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51693", "l": "prephenate + S-adenosyl-L-methionine => 3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190261", "l": "FGFR3c binds to FGF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211968", "l": "CYP2W1 oxidises INDOL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50473", "l": "anthraniloyl-CoA + H(+) + malonyl-CoA => (2-aminobenzoyl)acetyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187895", "l": "Engulfed CpG DNA binds to endosomal C-ter TLR9 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983298", "l": "IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693243", "l": "RHOD translocates to the Golgi membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57157", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 => 4-hydroxy-L-lysyl-[protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016629", "l": "12-oxophytodienoate reductase activity"}, {"i": "KEGG.REACTION:R03401"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043955", "l": "3-hydroxypropionyl-CoA synthetase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6813749", "l": "ALDH1A1 oxidises GA to DGA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57787", "l": "1,4-dinitrobenzene + NADH + O2 <=> 4-nitrocatechol + H(+) + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25787", "l": "2-dehydro-3-deoxy-L-rhamnonate <=> (S)-lactaldehyde + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000348", "l": "RANBP2 SUMOylates SP100 with SUMO2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5226979", "l": "ADD1:ADD2 binds DMTN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38859", "l": "beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP-alpha-D-glucose = bis(beta-D-gentiobiosyl) crocetin + H(+) + UDP"}, {"i": "EC:2.4.1.330", "l": "\"Beta-D-glucosyl crocetin beta-1,6-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14237", "l": "10-deoxysarpagine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sarpagine"}, {"i": "EC:1.14.14.136", "l": "\"Deoxysarpagine hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182876", "l": "Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16887", "l": "bilirubin IXalpha + bilirubin-bisglucuronoside => 2 bilirubin-glucuronoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47586", "l": "ganglioside GT1c (d18:1(4E)) + H(+) + UDP => ganglioside GT2 (d18:1(4E)) + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17145", "l": "2'-hydroxy-2,3-dihydrodaidzein + NADP(+) = 2'-hydroxydaidzein + 2 H(+) + NADPH"}, {"i": "EC:1.3.1.51", "l": "\"2'-hydroxydaidzein reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52930", "l": "2 GMP + 2 H(+) => cyclic di-3',5'-guanylate + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0008905", "l": "mannose-phosphate guanylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64412", "l": "H(+)(out) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) = H(+)(in) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11721", "l": "ATP + 2 H2O + N-methylhydantoin => ADP + 2 H(+) + N-carbamoylsarcosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48042", "l": "globoside Gb3Cer + N-acetyl-beta-D-galactosamine => globoside Gb4Cer + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10229", "l": "citrate => cis-aconitate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050401", "l": "xylonate dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62594", "l": "(6E)-8-oxogeranial + H(+) + NADPH => (S)-8-oxocitronellyl enol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24006", "l": "(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] => butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53511", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione <=> (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15309", "l": "(2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin] = biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.3.7.5", "l": "\"Phycocyanobilin:ferredoxin oxidoreductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-398185", "l": "LARG binds plexin B1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975118", "l": "TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033708", "l": "isocitrate-homoisocitrate dehydrogenase activity"}, {"i": "MetaCyc:RXN-7969"}, {"i": "EC:1.1.1.286", "l": "\"Isocitrate--homoisocitrate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57560", "l": "(+)-cis-trans-nepetalactol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 7-deoxyloganetate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.161", "l": "\"Nepetalactol monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30941", "l": "ADP + dITP => ATP + dIDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050419", "l": "hydroxymandelonitrile lyase activity"}, {"i": "RHEA:15977", "l": "(S)-4-hydroxymandelonitrile = 4-hydroxybenzaldehyde + hydrogen cyanide"}, {"i": "EC:4.1.2.11", "l": "\"Hydroxymandelonitrile lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36586", "l": "dTDP-alpha-D-fucose + NADP(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66741", "l": "ATP + H2O + N-acetyl-L-glutamate(in) => ADP + H(+) + N-acetyl-L-glutamate(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48434", "l": "ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] => ATP + N(6)-D-ribulosyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21506", "l": "1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde => acetoin + aldehydo-D-ribose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35195", "l": "L-quinate(in) = L-quinate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27699", "l": "GDP-beta-L-galactose + phosphate => beta-L-galactose 1-phosphate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33724", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-tetracosanoylsphinganine => a 1,2-diacyl-sn-glycerol + N-tetracosanoylsphinganine-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44080", "l": "ATP + CoA + undecanoate = AMP + diphosphate + undecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34284", "l": "2 L-tyrosine + O2 => 2 L-dopa"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3266566", "l": "G6PC2 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (islet) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388828", "l": "PD-1 binds B7DC and B7H1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28603", "l": "L-isoleucine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (1E,2S)-2-methylbutanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350598", "l": "Arginine<=>Agmatine+CO2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51017", "l": "7,8-dihydroneopterin 3'-phosphate => 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9604308", "l": "NICD4 traffics to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27956", "l": "diphosphate + presilphiperfolan-8beta-ol => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5679266", "l": "Beclin-1 complex translocates to the ER (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54266", "l": "(3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate => 2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58270", "l": "[protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide => [protein]-C-terminal glycine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52583", "l": "ATP + H2O + Pb(2+)(in) <=> ADP + H(+) + Pb(2+)(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39404", "l": "(2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH => (19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45711", "l": "3-dehydrocarnitine + acetyl-CoA <=> 3-dehydrocarnityl-CoA + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855232", "l": "RELN:VLDLR binds DAB1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23298", "l": "N-acetyl-D-mannosamine + pyruvate => N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35414", "l": "(E)-4-coumaroyl-CoA + an anthocyanidin 3-O-beta-D-glucoside <=> an anthocyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D--glucoside] + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40340", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210289", "l": "Recruitment of SYK to p-DAP12 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47776", "l": "guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(1145) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389523", "l": "BTLA interacts with HVEM (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43228", "l": "L-glutamine(104)-[histone H2A] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutamine(104)-[histone H2A] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53142", "l": "H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247843", "l": "secretion of WNT ligands (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20523", "l": "acetoacetate + H(+) + NADH => (R)-3-hydroxybutanoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58932", "l": "4 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 8 H(+) + malonyl-CoA + 4 NADPH = 5 CO2 + 6 CoA + demethylluteothin + 3 H2O + 4 NADP(+)"}, {"i": "EC:2.3.1.289", "l": "\"Aureothin polyketide synthase system\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807578", "l": "GNLY binds the bacterial cell surface in the phagosome (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034926", "l": "pyrene-4,5-epoxide hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46684", "l": "3-oxochol-4-en-24-oyl-CoA + A = (22E)-3-oxo-chol-4,22-dien-24-oyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30778", "l": "H2O + O2 + pyridoxamine <=> H2O2 + NH4(+) + pyridoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49798", "l": "a fatty acid + glycine => an N-(fatty acyl)-glycine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66361", "l": "(7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H2O => (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50027", "l": "dodecanoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + dodecanoyl-4'-phosphopantetheine + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43313", "l": "ATP + N-(hexanoyl)sphing-4-enine => ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392870", "l": "Gs activation by prostacyclin receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49720", "l": "2 H(+) + NADH + 2 O2 + protoviolaceinate = CO2 + 2 H2O + NAD(+) + violacein"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29909", "l": "glycerol + H(+) + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phospho-(1'-rac-glycerol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1013020", "l": "Activation of GIRK/Kir3 Channels (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983266", "l": "Kinesins bind microtubules (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40261", "l": "(3S)-hydroxyhexadecanedioyl-CoA => (2E)-hexadecenedioyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692779", "l": "p-S182 MAPKAPK5 phosphorylates FOXO1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40302", "l": "6-deoxyerythronolide B + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> erythronolide B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033529", "l": "TYSND1 cleaves ACAA1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32910", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + 2 H2O <=> 2 a carboxylate + 2 H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12458", "l": "CDP-L-ribitol + diphosphate => CTP + D-ribitol 5-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39245", "l": "(3R)-hydroxy-(11Z)-eicosenoyl-CoA + NADP(+) => (11Z)-3-oxoicosenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63712", "l": "2 [Fe(II)-cytochrome b5] + a (7Z,10Z,13Z,16Z)-docosatetraenoyl derivative + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl derivative + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36341", "l": "2-thio-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine => [sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2002460", "l": "P4HB binds Collagen chains (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17270", "l": "macrocin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + tylosin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35361", "l": "(2E)-15-methylhexadecenoyl-CoA + H2O => 3-hydroxyisoheptadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11698", "l": "H(+) + S-adenosyl-L-homocysteine + staurosporine => 3'-demethylstaurosporine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56753", "l": "a 14alpha-methyl steroid + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => a Delta(14) steroid + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12478", "l": "formate + L-glutamate => H2O + N-formyl-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876472", "l": "NPC2 binds CHOL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44258", "l": "1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6793666", "l": "MDM2 translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23332", "l": "(2R)-3-phosphoglycerate + GTP = (2R)-3-phospho-glyceroyl phosphate + GDP"}, {"i": "EC:2.7.2.10", "l": "\"Phosphoglycerate kinase (GTP)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382061", "l": "Extracellular processing of novel PDGFs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.50"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004648", "l": "O-phospho-L-serine:2-oxoglutarate aminotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22342", "l": "3-hydroxybenzaldehyde + H(+) + NADPH => 3-hydroxybenzyl alcohol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374663", "l": "DCC interaction with Ezrin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51614", "l": "(R)-malate + 2-oxoglutarate => (R)-2-hydroxyglutarate + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102818", "l": "lycopene cleavage oxygenase activity"}, {"i": "MetaCyc:RXN-8236"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2467775", "l": "Autocleavage of ESPL1 (Separase) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022877", "l": "protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004498", "l": "calcidiol 1-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10738", "l": "an aldehyde + H(+) + NADH => a primary alcohol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62707", "l": "glycyldehydrophenylalanine + H2O <=> 2,3-didehydrophenylalanine + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57017", "l": "3,6-dichloro-2-methoxybenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3,6-dichlorosalicylate + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17126", "l": "H2O + N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine => 2-oxoglutarate + N-(2-aminobutanoyl)glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229132", "l": "AP4 binds APP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029473", "l": "Branching and elongation of mother and daughter filaments (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211712", "l": "Proteolytic PAK-2p34 fragment translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53824", "l": "NAD(+) + taurochenodeoxycholate = 7-oxotaurolithocholate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n4"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140413", "l": "zinc:bicarbonate:selenite symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57925", "l": "H2O + mutildienyl diphosphate => diphosphate + premutilin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12031", "l": "H2O + L-5-carboxymethylhydantoin <=> H(+) + N-carbamoyl-L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39767", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3209165", "l": "ID1 sequesters ETS2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44173", "l": "H2O + NAD(+) + tetradecanal => 2 H(+) + NADH + tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161794", "l": "Arachidonic acid is converted to HXA3/B3 by ALOX12 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47952", "l": "[prokaryotic ubiquitin-like protein]-C-terminal-L-glutamine + H2O = [prokaryotic ubiquitin-like protein]-C-terminal-L-glutamate + NH4(+)"}, {"i": "EC:3.5.1.119", "l": "\"Pup amidohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177930", "l": "GAB1 phosphorylation by EGFR kinase (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65145", "l": "2-oxoglutarate + berkeleyone A + O2 => CO2 + H2O + preaustinoid A + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29161", "l": "3 a menaquinone(in) + 2 H2O(out) + NH4(+)(out) => 3 a menaquinol(in) + 2 H(+)(out) + nitrite(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17558", "l": "anthranilate + malonyl-CoA => CoA + N-malonylanthranilate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051287", "l": "NAD binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18996", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10373", "l": "CoA + NAD(+) + phenylglyoxylate => benzoyl-CoA + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42005", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) => 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13114", "l": "2-acetamidofluorene + H2O + NADP(+) => H(+) + N-hydroxy-2-acetamidofluorene + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870289", "l": "PUS3 transforms uridine-39 to pseudouridine-39 in tRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48421", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) => CMP + ganglioside GM1 (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909726", "l": "Phosphorylation of STAT1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050683", "l": "AF-1 domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12518", "l": "(+)-(R)-germacrene A + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654569", "l": "Activated FGFR1 binds FRS2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199131", "l": "PVR binds CD226 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112430", "l": "Formation of P-TEFb complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48197", "l": "H(+) + heptadecanoyl-CoA + oxidized [electron-transfer flavoprotein] => reduced [electron-transfer flavoprotein] + trans-2-heptadecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63266", "l": "1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28045", "l": "CoA + NAD(+) + pyruvate <=> acetyl-CoA + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204169", "l": "PDP dephosphorylates p-lipo-PDH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809254", "l": "MTMR8 binds MTMR9 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111238", "l": "Formation of ADAR2  homodimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9690449", "l": "S1PR1 bind S1P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27343", "l": "A + H(+) + H2O + hydroxylamine => AH2 + NH4(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12657", "l": "a (2S)-2-methylacyl-CoA = a (2R)-2-methylacyl-CoA"}, {"i": "EC:5.1.99.4", "l": "\"Alpha-methylacyl-CoA racemase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803935", "l": "TP53 binds the PLAGL1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70486", "l": "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25611", "l": "beta-D-allopyranose => beta-D-allofuranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68615", "l": "Formation of ORC(1-6) complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432897", "l": "ILK interacts with beta-1 integrin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28455", "l": "N(6)-(D-fructosyl)-L-lysine(in) => N(6)-(D-fructosyl)-L-lysine(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045548", "l": "phenylalanine ammonia-lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62419", "l": "(E)-4-coumaroyl-CoA + H2O <=> 4-hydroxybenzaldehyde + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25574", "l": "diphosphate + sclareol => geranylgeranyl diphosphate + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-947514", "l": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044588", "l": "laminaribiose binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37969", "l": "D-galactose + H(+) + NADPH => galactitol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16564", "l": "H2O + squalene <=> hopan-22-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13806", "l": "A + a 3-oxo-5alpha-steroid => a 3-oxo-Delta(4)-steroid + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354087", "l": "Recruitment of GRB2 to p-PTK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912505", "l": "Synapsis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928631", "l": "GIT1 binds bPIX (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23969", "l": "(E)-coniferaldehyde + H2O + NAD(+) => (E)-ferulate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17865", "l": "5,6,7,8-tetrahydropteridine + NADP(+) = 6,7-dihydropteridine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3095901", "l": "ABCC1 transports cytosolic Cbl to extracellular region (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18118", "l": "L-tyrosine + O2 => H2O + L-dopaquinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58356", "l": "2-oxoglutarate + N(omega)-methyl-L-arginyl-[protein] + O2 = CO2 + formaldehyde + L-arginyl-[protein] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848596", "l": "PTK6 binds PXN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32863", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177920", "l": "Binding of GRB2 to GAB1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033691", "l": "sialic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668404", "l": "TNFA binds TNFR2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35594", "l": "H2 + n sulfur <=> H(+) + hydrogen sulfide + (n-1) sulfur"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14268", "l": "(S)-4-amino-5-oxopentanoate <=> 5-aminolevulinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210282", "l": "Interaction of GPVI and FceRI gamma (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57400", "l": "3-O-acetylpapaveroxine + H2O = acetate + H(+) + narcotine hemiacetal"}, {"i": "EC:3.1.1.105", "l": "\"3-O-acetylpapaveroxine carboxylesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49575", "l": "Fe-coproporphyrin III + 2 H(+) <=> coproporphyrin III + Fe(2+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47082", "l": "17beta-hydroxy-5beta-estran-3-one + NADP(+) => 17beta-hydroxyestr-4-en-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58804", "l": "5'-pApG-3' + H2O = 5'-ApG-3' + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35108", "l": "3-nitrotyramine + H2O + O2 => 4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26379", "l": "cyclic pyranopterin phosphate + diphosphate => GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047433", "l": "branched-chain-2-oxoacid decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18764", "l": "a 1,2-diacyl-sn-glycerol + H2O <=> a fatty acid + a monoacylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19128", "l": "glyoxylate + L-serine <=> 3-hydroxypyruvate + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912627", "l": "CBL ubiquitinates PI3K (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61463", "l": "a cytidine in RNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47054", "l": "alpha-selinene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24278", "l": "acetyl phosphate + phosphate => acetate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050365", "l": "tryptophanamidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.60"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799733", "l": "Semiquinone reacts with oxygen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31415", "l": "(2Z,6E)-farnesyl diphosphate = (+)-2-epi-prezizaene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25424", "l": "diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate + guanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31194", "l": "(3S)-hydroxydecanoyl-CoA <=> (2E)-decenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031882", "l": "type 5 somatostatin receptor binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004462", "l": "lactoylglutathione lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187506", "l": "Translocation of p27 to the nucleoplasm (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "75.848614326174683", "identifiers": [{"i": "GO:0008238", "l": "exopeptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22087", "l": "(S)-2,3-diaminopropanoate + H(+) + H2O <=> 2 NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49201", "l": "D-mannose 6-phosphate + H2O + phosphoenolpyruvate => 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33010", "l": "(+)-artemisinic alcohol + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-artemisinic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3296301", "l": "CCRL2 binds CCL19 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51261", "l": "4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] => (10bR,4aS)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12991", "l": "D-mannose + dolichyl phosphate + H(+) => dolichyl beta-D-mannosyl phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158849", "l": "Phenol can form a sulfate conjugate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678927", "l": "UNC93B1 delivers endosomal full-length TLRs to endolysosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54957", "l": "ATP + CoA + OPC-6 => AMP + diphosphate + OPC-6-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36134", "l": "(indol-3-yl)acetate + S-adenosyl-L-methionine <=> methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54006", "l": "(11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047630", "l": "ADP-phosphoglycerate phosphatase activity"}, {"i": "RHEA:15861", "l": "3-ADP-2-phosphoglycerate + H2O = 3-ADP-glycerate + phosphate"}, {"i": "EC:3.1.3.28", "l": "\"ADP-phosphoglycerate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40458", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA <=> (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41802", "l": "3-oxobutanoyl-[ACP] + CO2 + holo-[ACP] => acetyl-[ACP] + H(+) + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22033", "l": "3-oxalomalate => glyoxylate + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5651789", "l": "LIG1 bound to POLB ligates SSB (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70486", "l": "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.42"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11325", "l": "all-trans-octaprenyl diphosphate + isopentenyl diphosphate => all-trans-nonaprenyl diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36566", "l": "GDP-beta-L-colitose + NADP(+) <=> GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24237", "l": "2 [Fe(III)cytochrome c] + H2O + trimethylamine => 2 [Fe(II)cytochrome c] + 3 H(+) + trimethylamine N-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944225", "l": "Association of procollagen type XVII (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22777", "l": "2 H(+) + H2O2 + 2 Mn(2+) => 2 H2O + 2 Mn(3+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047803", "l": "cysteine lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.69", "l": "\"Type 1 galactoside alpha-(1,2)-fucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350578", "l": "NQO1 interaction with ODC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54636", "l": "(13E)-labda-7,13-dien-15-yl diphosphate = diphosphate + labda-7,13(16),14-triene"}, {"i": "EC:4.2.3.192", "l": "\"Labda-7,13(16),14-triene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58555", "l": "15alpha-stemmadenine intermediate II + H2O <=> (16R)-deshydroxymethyl-stemmadenine + formate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106238", "l": "peregrinol diphosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086132", "l": "Dentin phosphoprotein binds integrin alphaVbeta1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49086", "l": "(-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205289", "l": "Autophosphorylation of KIT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43040", "l": "hexadecanoyl-CoA + hexadecasphinganine = CoA + H(+) + N-hexadecanoylhexadecasphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9692809", "l": "CDC42 binds effectors at the ER membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800396", "l": "TP53 stimulates PIDD1 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6813749", "l": "ALDH1A1 oxidises GA to DGA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050312", "l": "sulfoacetaldehyde lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49299", "l": "keto-L-sorbose(out) + N(pros)-phospho-L-histidyl-[protein] <=> L-histidyl-[protein] + L-sorbose 1-phosphate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36638", "l": "4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33198", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656356", "l": "Defective SLC5A1 does not cotransport Glc and Na+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707523", "l": "Hemes bind to BACH1:MAFK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685011", "l": "ATR activation at DNA DSBs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21055", "l": "(2S)-2-hydroxypropyl-coenzyme M + NAD(+) <=> 2-oxopropyl-coenzyme M + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.84"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198756", "l": "ERK1/2 phosphorylates MSK1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047811", "l": "D-alanine gamma-glutamyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-74986", "l": "Elongation of pre-rRNA transcript (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432121", "l": "LDL binds to LRP8 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050566", "l": "asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42728", "l": "S-adenosyl-L-methionine + uridine(2791) in 21S rRNA = 2'-O-methyluridine(2791) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.168", "l": "\"21S rRNA (uridine(2791)-2'-O)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645598", "l": "RRAGC,D hydrolyzes GTP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35882", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46076", "l": "(2E)-eicosenoyl-CoA + H(+) + NADH = eicosanoyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44357", "l": "nogalaviketone => methyl nogalonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39369", "l": "(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+) => (2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60562", "l": "S-adenosyl-L-homocysteine + S-methyl-L-methionyl-[protein] => L-methionyl-[protein] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76031", "l": "2 H2O2 => O2 + 2 H2O (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60363", "l": "FMN + H(+) + oxidized coenzyme F420-0 <=> dehydro coenzyme F420-0 + FMNH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981610", "l": "Neuroglobin binds oxygen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44907", "l": "alpha-D-glucose 6-phosphate + H2O <=> alpha-D-glucose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32589", "l": "(3R,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+) => (1R,4R)-dihydrocarvone + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64212", "l": "an N-(fatty acyl)-L-isoleucine + H2O = a fatty acid + L-isoleucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46269", "l": "2 [Fe(II)-cytochrome b5] + an N-acyl-(4R)-4-hydroxysphinganine + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61543", "l": "ent-kaur-16-en-19-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> ent-kaur-16-en-19-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20922", "l": "3,5-dichlorocatechol + H2O + NADP(+) => 2,4-dichlorophenol + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14820", "l": "4-maleylacetoacetate <=> 4-fumarylacetoacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56990", "l": "6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380949", "l": "AMPK is dephosphorylated (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4570528", "l": "SUMOylation of XPC with SUMO1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41539", "l": "2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine <=> 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981713", "l": "C4b binds to cell surface (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102809", "l": "delphinidin 3-O-glucoside 2''-O-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-8178"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39183", "l": "3-oxodocosanoyl-CoA + H(+) + NADPH = (3R)-hydroxydocosanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203979", "l": "Coat Assembly (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56870", "l": "(2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA => (2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40672", "l": "2-iminopropanoate + H2O => NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264997", "l": "Oxidation of cysteine to cystine in Proinsulin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63395", "l": "A + Fe(II)-heme o + H2O <=> AH2 + Fe(II)-heme i"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55822", "l": "5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide d + H(+) + L-methionine => a 7(1)-hydroxybacteriochlorophyllide d + H2O + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730872", "l": "Activation of Calcineurin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120022", "l": "glucagon family peptide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31242", "l": "4 H(+) + uroporphyrinogen I <=> 4 CO2 + coproporphyrinogen I"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28758", "l": "a ubiquinone + sn-glycerol 3-phosphate <=> a ubiquinol + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64756", "l": "H2O + S-benzyl-L-cysteine = benzylthiol + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629483", "l": "NEIL3 cleaves spiroiminodihydantoin from damaged telomeric DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24235", "l": "2-dehydro-3-deoxy-D-gluconate + NAD(+) <=> 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62011", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose <=> alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23575", "l": "3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 3 CO2 + 4 CoA + phlorisovalerophenone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41737", "l": "3'-phosphoadenylyl sulfate + a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) => adenosine 3',5'-bisphosphate + beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30183", "l": "L-galactonate + NAD(+) = H(+) + keto-D-tagaturonate + NADH"}, {"i": "EC:1.1.1.414", "l": "\"L-galactonate 5-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24542", "l": "AH2 + D-glucono-1,5-lactone => A + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38614", "l": "NAD(+) <=> cyclic ADP-ribose + H(+) + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18460", "l": "D-ribulose 5-phosphate <=> (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31941", "l": "DIBOA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15275", "l": "3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate => 2-oxoglutarate + L-dopa"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712084", "l": "PI3K synthesizes PIP3 downstream of ALK mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27903", "l": "caffeine + H2O + ubiquinone-0 => 1,3,7-trimethylurate + ubiquinol-0"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811454", "l": "MAPKs phosphorylate PP2A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10896", "l": "2 H2O + limonin = 2 H(+) + limonoate"}, {"i": "EC:3.1.1.36", "l": "\"Limonin-D-ring-lactonase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52723", "l": "5-methyluridine(54) in tRNA + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + ATP + H2O <=> 5-methyl-2-thiouridine(54) in tRNA + [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + AMP + diphosphate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35794", "l": "2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-kanosamine <=> H(+) + kanamycin X + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065966", "l": "SREBP1A,1C,2 binds the TM7SF2 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32084", "l": "CTP + pseudaminate => CMP-pseudaminate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57706", "l": "3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADPH => (2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53251", "l": "cholesta-5,7-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxycholest-5-en-7-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41170", "l": "a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098882", "l": "structural constituent of presynaptic active zone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626988", "l": "TNF-alpha:TNFR1 binds NSMAF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22960", "l": "formononetin + O2 + reduced [NADPH--hemoprotein reductase] = calycosin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.88", "l": "\"Isoflavone 3'-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43740", "l": "ATP + CoA + hexanoate = AMP + diphosphate + hexanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005247", "l": "voltage-gated chloride channel activity"}, {"i": "REACT:R-HSA-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874205", "l": "MBTPS1 (S1P) cleaves CREB3L2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050355", "l": "triphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005034", "l": "osmosensor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22610", "l": "(2S,6S)-2,6-diaminoheptanedioate + succinate => H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57624", "l": "dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = 3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30725", "l": "AH2 + 2 ATP + H2O + hydroxylamine => A + 2 ADP + H(+) + NH4(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174070", "l": "Association of Cdh1 with the APC/C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38052", "l": "2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA => 1-butyryl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981497", "l": "ST3GAL1-4 can add a sialic acid to the T antigen at the alpha 3 position (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190245", "l": "FGFR1b binds to FGF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40995", "l": "3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA = 4-hydroxybenzaldehyde + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043851", "l": "methanol-specific methylcobalamin:coenzyme M methyltransferase activity"}, {"i": "MetaCyc:RXN-8096"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25678", "l": "ATP + O-phospho-L-serine + tRNA(Cys) = AMP + diphosphate + O-phospho-L-seryl-tRNA(Cys)"}, {"i": "EC:6.1.1.27", "l": "\"O-phosphoserine--tRNA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33184", "l": "citrate(in) => citrate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40172", "l": "dodecanoyl-CoA + O2 => (2E)-dodecenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70596", "l": "GOT2 dimer deaminates L-Asp (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050117", "l": "N-acetyl-beta-alanine deacetylase activity"}, {"i": "KEGG.REACTION:R00909"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32674", "l": "ATP + UDP-N-acetyl-alpha-D-glucosamine <=> ADP + H(+) + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878212", "l": "JAG1 gene expression is inhibited by RUNX3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578777", "l": "DMPK phosphorylates PLN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21136", "l": "(R)-carnitine + acetyl-CoA = CoA + O-acetyl-(R)-carnitine"}, {"i": "EC:2.3.1.7", "l": "\"Carnitine O-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061675", "l": "RBL family protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40217", "l": "FAD + H(+) + H2O2 => FADH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2545253", "l": "Deacetylation of cohesin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222237", "l": "SMYD2 methylates TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419426", "l": "Cannabinoid receptors can bind cannabinoids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809309", "l": "MTMR6 binds MTMR9 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23510", "l": "(7R)-7-aminocephalosporanate + glutarate => (7R)-7-(4-carboxybutanamido)cephalosporanate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48293", "l": "ganglioside GM1 + GDP-beta-L-fucose => ganglioside Fuc-GM1 + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57358", "l": "CO2 + H2O + hapalindole G + succinate => 2-oxoglutarate + chloride + H(+) + hapalindole U + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59627", "l": "H2O + N(2)-(4-aminobutanoyl)-L-ornithine <=> 4-aminobutanoate + L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.45"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070866", "l": "sterol-dependent protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15846", "l": "4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP-alpha-D-glucose => 4-O-{[(2R)-2-alpha-D-glucosyl-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n H(+) + n UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45851", "l": "(3R)-3-hydroxydodecanoyl-CoA + NADP(+) <=> 3-oxododecanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57256", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP = GTP + H(+) + lactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48832", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72672", "l": "The 60S subunit joins the translation initiation complex  (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17280", "l": "6-phospho-D-gluconate <=> 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18749", "l": "[protein]-dithiol + NAD(+) = [protein]-disulfide + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59409", "l": "H2O + N-acetyl-L-aspartate => acetate + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30215", "l": "a menaquinol + 2 nitric oxide = a menaquinone + H2O + nitrous oxide"}, {"i": "EC:1.7.5.2", "l": "\"Nitric oxide reductase (menaquinol)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44656", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a monoacyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102465", "l": "zeaxanthin 2,2'-beta-hydroxylase activity"}, {"i": "MetaCyc:RXN-14018"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938887", "l": "PML binds RUNX1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41394", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+) => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58352", "l": "2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + O2 = CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375133", "l": "Basigin binds Mannose-carrying cell recognition molecules (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176956", "l": "Formation of GINS complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675790", "l": "MTORC1 dissociates from ULK complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018754", "l": "GDIs bind RHOH (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64397", "l": "glycyl-sarcosine(out) + H(+)(out) => glycyl-sarcosine(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132222", "l": "Cleavage of factor B to form classical C3 convertase  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392870", "l": "Gs activation by prostacyclin receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27481", "l": "(S)-columbianetin + O2 + reduced [NADPH--hemoprotein reductase] = acetone + angelicin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.148", "l": "\"Angelicin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052900", "l": "spermine oxidase (propane-1,3-diamine-forming) activity"}, {"i": "RHEA:25824", "l": "H2O + O2 + spermine = H2O2 + N-(3-aminopropyl)-4-aminobutanal + propane-1,3-diamine"}, {"i": "EC:1.5.3.14", "l": "\"Polyamine oxidase (propane-1,3-diamine-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31112", "l": "acetyl-CoA + butanoyl-CoA => 3-oxohexanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21576", "l": "carnitine + H(+) = 2-methylcholine + CO2"}, {"i": "EC:4.1.1.42", "l": "\"Carnitine decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015454", "l": "light-driven active transmembrane transporter activity"}, {"i": "TCDB:3.E"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51401", "l": "octadecanoyl-CoA + serotonin => CoA + H(+) + N-octadecanoyl-serotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58964", "l": "H2O + hexanal + O2 = H(+) + H2O2 + hexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60785", "l": "2-oxoglutarate + gibberellin A24 + O2 => CO2 + gibberellin A25 + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51716", "l": "ATP(in) + CoA(in) + H(+)(out) + hexadecanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + hexadecanoyl-CoA(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45576", "l": "(2R)-ethylmalonyl-CoA = (2S)-methylsuccinyl-CoA"}, {"i": "EC:5.4.99.63", "l": "\"Ethylmalonyl-CoA mutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390930", "l": "5-HT2 receptor can bind serotonin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68610", "l": "Formation of ORC(2-5) complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466718", "l": "NRPE dissociates to atRAL and PE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848975", "l": "PTK6 phosphorylates KHDRBS1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9604308", "l": "NICD4 traffics to the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50864", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 = 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36909", "l": "(13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + CO2 + CoA => (11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53075", "l": "2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11002", "l": "a D-alpha-amino acid + CO2 + NH4(+) => an N-carbamoyl-D-amino acid + 2 H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66898", "l": "4 H(+) + 6 H2O + ophiobolin C + 4 oxidized [NADPH--hemoprotein reductase] => 4 O2 + ophiobolin F + 4 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5660660", "l": "p300 acetylates RELA subunit (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669012", "l": "EDA binds EDAR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212222", "l": "PRC2 recruits DNA methyltransferases (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64179", "l": "H2O + N-(9Z-octadecenoyl)-L-tryptophan <=> (9Z)-octadecenoate + L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71303", "l": "RPE dimers isomerise RU5P to XY5P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932184", "l": "Expression of HIGD1A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047096", "l": "androst-4-ene-3,17-dione monooxygenase activity"}, {"i": "RHEA:22696", "l": "AH2 + androst-4-ene-3,17-dione + O2 = A + H2O + testololactone"}, {"i": "EC:1.14.99.12", "l": "\"Androst-4-ene-3,17-dione monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632386", "l": "TP63/TP53 stimulates transcription of DDIT4 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033980", "l": "phosphonopyruvate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36027", "l": "CoA + NAD(+) + propanal = H(+) + NADH + propanoyl-CoA"}, {"i": "EC:1.2.1.87", "l": "\"Propanal dehydrogenase (CoA-propanoylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23378", "l": "3-dehydro-D-erythronate + H(+) + NADH => L-threonate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22225", "l": "3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA => 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52855", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin] <=> 6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.24"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901640", "l": "XTP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43423", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + ATP <=> 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008661", "l": "1-deoxy-D-xylulose-5-phosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43741", "l": "ATP + CoA + hexanoate => AMP + diphosphate + hexanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050055", "l": "limonin-D-ring-lactonase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085083", "l": "Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417843", "l": "P2Y13 binds ADP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34603", "l": "15-methylhexadecasphinganine + a fatty acyl-CoA = CoA + H(+) + N-acyl-15-methylhexadecasphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33127", "l": "H2O + salicin-6-phosphate = beta-D-glucose 6-phosphate + salicyl alcohol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4093329", "l": "EFNBs bind SDCBP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33926", "l": "(1R,4R)-5-oxo-1,2-campholide <=> [(1R)-2,2,3-trimethyl-2-oxocyclopent-3-en-1-yl]acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66444", "l": "hexan-3-one + NADP(+) = (E)-4-hexen-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31782", "l": "an all-trans-retinyl ester + H2O <=> 13-cis-retinol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38965", "l": "ADP + H(+) + leukotriene C4(out) + phosphate => ATP + H2O + leukotriene C4(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55208", "l": "(4R)-hydroxysphinganine 1-phosphate = (2R)-hydroxyhexadecanal + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39712", "l": "O2 + 2 reduced coenzyme F420-(gamma-Glu)(n) => 2 H(+) + 2 H2O + 2 oxidized coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5082391", "l": "Trimerization of HSF1 in the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952128", "l": "RUNX3 binds TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668605", "l": "RAC2:GTP binds NOX2 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47818", "l": "9-ribosyl-trans-zeatin 5'-diphosphate + H2O + NADP(+) => H(+) + N(6)-(dimethylallyl)adenosine 5'-diphosphate + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1606273", "l": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-996727", "l": "REST recruits the BHC complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74707", "l": "Binding of IRS to insulin receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16991", "l": "1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate => 1D-myo-inositol hexakisphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35309", "l": "2,5-dihydroxybenzoate + H2O + NAD(+) => H(+) + NADH + O2 + salicylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40854", "l": "FAD + H(+) + pentadecanoyl-CoA <=> (2E)-pentadecenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140496", "l": "gamma-tubulin complex binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090686", "l": "glycine betaine-activated nonselective monovalent cation channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58761", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + NADPH => 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33389", "l": "aminopropylcadaverine + H(+) + S-methyl-5'-thioadenosine => cadaverine + S-adenosyl 3-(methylsulfanyl)propylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50212", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50221", "l": "(S)-demethyl-4-deoxygadusol => (R)-demethyl-4-deoxygadusol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204798", "l": "Interaction of Tie2 and p85 of PI3K (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013110", "l": "RHOC binds effectors at the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004739", "l": "pyruvate dehydrogenase (acetyl-transferring) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72180", "l": "Cleavage of mRNA at the 3'-end (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47940", "l": "ganglioside GM2 (d18:1(4E)) + H2O = ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2247510", "l": "MARCO:ligand is endocytosed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53606", "l": "1-hexadecanoyl-sn-glycerol + phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983144", "l": "Transport of Antigen peptide in to ER (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35121", "l": "bisdemethoxycurcumin + CO2 + 2 CoA => (4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373145", "l": "fumarate + H2O <=> malate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74258", "l": "XDH oxidizes xanthine to form urate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708466", "l": "BACH1 translocates from the nucleoplasm to the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45510", "l": "(2R,3E)-phycoerythrobilin + apo-[C-phycoerythrin beta-subunit] => [C-phycoerythrin beta-subunit]-Cys(84)-phycoerythrobilin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34096", "l": "carboxyspermidine + H(+) => CO2 + spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382055", "l": "Grb7 binds to the active PDGF receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60820", "l": "H2O + NADPH = adenosine 3',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52031", "l": "a jasmonyl-L-amino acid + H2O <=> a jasmonate + an L-alpha-amino acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43851", "l": "[thioredoxin]-dithiol + arsenate + H(+) <=> [thioredoxin]-disulfide + arsenite + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60138", "l": "a (8S,9R)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate => a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13096", "l": "an N-acylsphing-4-enine + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26075", "l": "D-glucuronate + H(+) + UDP => H2O + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2219524", "l": "PDPK1 binds PIP2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421836", "l": "trans-Golgi Network Derived Vesicle Uncoating (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200908", "l": "Nef Binds and activates the Src-family tyrosine kinase Fyn (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55799", "l": "H(+) + NADH + O2 + phenol <=> H2O + hydroquinone + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050033", "l": "L-rhamnono-1,4-lactonase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592240", "l": "Formation of NRF2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050052", "l": "leukotriene-E4 20-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66800", "l": "miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + miltiradien-20-al + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66112", "l": "2-oxobutanoate + L-tyrosine = (2S)-2-aminobutanoate + 3-(4-hydroxyphenyl)pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57154", "l": "(3S)-3-hydroxy-L-lysyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-lysyl-[protein] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28176", "l": "colneleate + H2O => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36990", "l": "CMP + phosphate <=> alpha-D-ribose 1,5-bisphosphate + cytosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57580", "l": "S-methyl-5-thio-D-ribulose 1-phosphate = S-methyl-1-thiol-D-ribulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10050", "l": "acetate + H(+) + L-methionine => methanethiol + O-acetyl-L-homoserine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800120", "l": "POU5F1 (OCT4), SOX2, NANOG bind DPPA4 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25447", "l": "(2E,6E)-farnesyl diphosphate <=> (1E,4E)-germacrene B + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55363", "l": "11-cis-retinol <=> 9-cis-retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22587", "l": "2 H(+) + heme b <=> Fe(2+) + protoporphyrin IX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54014", "l": "(8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4085083", "l": "Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48550", "l": "[phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol => [phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11017", "l": "allantoate + H2O => (S)-ureidoglycolate + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50434", "l": "A + H2O + prostaglandin H1 => AH2 + prostaglandin G1"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004608", "l": "phosphatidylethanolamine N-methyltransferase activity"}, {"i": "RHEA:11164", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.17", "l": "\"Phosphatidylethanolamine N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37362", "l": "D-glucosamine(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-glucosamine 6-phosphate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61918", "l": "ADP + fluconazole(out) + H(+) + phosphate => ATP + fluconazole(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033438", "l": "ACC codon-amino acid adaptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046429", "l": "4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-447130", "l": "Interleukin-23 binds interleukin-23 receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41875", "l": "3-oxododecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxydodecanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.28"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983147", "l": "Release of E3 from polyubiquitinated substrate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13248", "l": "D-threo-isocitrate <=> glyoxylate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58372", "l": "(E)-oct-2-en-1-ol + NADP(+) = (2E)-octenal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47726", "l": "5-oxo-L-proline + L-cysteinylglycine => glutathione"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032184", "l": "SUMO polymer binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13137", "l": "cycloartenol + S-adenosyl-L-methionine = cyclolaudenol + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.142", "l": "\"Cycloartenol 24-C-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847968", "l": "PTEN binds FRK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27940", "l": "glycine + glyoxylate => (3R)-3-hydroxy-D-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62810", "l": "2 H2O + julichrome Q6-6 + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + 2 julichrome Q6 + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033134", "l": "ubiquitin activating enzyme binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803978", "l": "S-nitrosylation of cysteine residues in proteins by N2O3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70241", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784959", "l": "BPHL hydrolyses VACV to ACV (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678920", "l": "TLR processing at low pH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353265", "l": "Interaction between two DNA-PK:DNA complexes at opposing ends of DNA DSB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53907", "l": "ATP + L-threonyl-[tau protein] <=> ADP + H(+) + O-phospho-L-threonyl-[tau protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48529", "l": "ganglioside GP1c (d18:1(4E)) + H2O => ganglioside GQ1c (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10756", "l": "ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250220", "l": "Homodimerization of ERBB4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37643", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5632738", "l": "DDIT4 binds 14-3-3 dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30093", "l": "a ubiquinol + NH4(+) + pyruvate => a ubiquinone + D-alanine + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102240", "l": "soyasapogenol B glucuronide galactosyltransferase activity"}, {"i": "MetaCyc:RXN-12319"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198440", "l": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21267", "l": "A + glycolate <=> AH2 + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32181", "l": "dipicolinate + H(+) + NADH => (S)-2,3-dihydrodipicolinate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56746", "l": "(3R)-3-hydroxy-L-arginyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-arginyl-[protein] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210430", "l": "Release of L-Glutamate at the synapse (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388809", "l": "CTLA-4 binds B7-1/B7-2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8871227", "l": "RET binds GFRA4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16916", "l": "a CDP-1,2-diacyl-sn-glycerol + L-serine <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102682", "l": "N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46144", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5686430", "l": "MUS81 binds EME1, EME2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187382", "l": "Degradation of ubiquitinated SMAD3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66304", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-mannosylinositol-1-phosphoceramide = a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-alpha-mannosylinositol-1-phosphoceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22467", "l": "L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10743", "l": "a secondary alcohol + NAD(+) <=> a ketone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36791", "l": "H2O + N(omega)-hydroxy-L-arginine = hydroxyurea + L-ornithine"}, {"i": "EC:3.5.3.25", "l": "\"N(omega)-hydroxy-L-arginine amidinohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879222", "l": "MDP:NLRP1 binds ATP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388468", "l": "AVP(20-28) binds AVPR1A,B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.10", "l": "\"2-haloacid dehalogenase (configuration-inverting)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41943", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate <=> [amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14742", "l": "4-methylene-L-glutamine + H2O => 4-methylene-L-glutamate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376851", "l": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32445", "l": "all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => all-trans-zeaxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46854", "l": "5alpha-cholest-8-en-3beta-ol + NADP(+) => 5alpha-cholest-8-en-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2467794", "l": "Resolution of sister chromatids (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9604308", "l": "NICD4 traffics to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10131", "l": "all-trans-violaxanthin <=> all-trans-neoxanthin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45012", "l": "H2O + N-octadecanoyl-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004734", "l": "pyrimidodiazepine synthase activity"}, {"i": "RHEA:10720", "l": "2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione"}, {"i": "EC:1.5.4.1", "l": "\"Pyrimidodiazepine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450466", "l": "AUF1:mRNA complex is destroyed (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050534", "l": "3-deoxyoctulosonase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42038", "l": "7-oxolithocholate + H(+) + NADH => chenodeoxycholate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022869", "l": "protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022876", "l": "protein-N(PI)-phosphohistidine-galactosamine phosphotransferase system transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58898", "l": "4-hydroxybutanoyl-CoA + ADP + phosphate => 4-hydroxybutanoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62098", "l": "2-(9Z-octadecenoyl)-glycerol + phosphate => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49386", "l": "(12R),18-dihydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (12R)-hydroxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44368", "l": "Cr(6+) + 2 NADPH + O2 = Cr(3+) + 2 H(+) + 2 NADP(+) + superoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55224", "l": "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50956", "l": "cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine = H(+) + N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine"}, {"i": "RHEA:50960", "l": "cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine = H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.268", "l": "\"tRNA(Thr) (cytosine(32)-N(3))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41493", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000120", "l": "CBLIF binds Cbl (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005461", "l": "UDP-glucuronic acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391868", "l": "Dephosphorylation of NCAM1 bound pFyn (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57262", "l": "GDP + H(+) + lactate => H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11615", "l": "H2O + L-glutamate + NADP(+) <=> 2-oxoglutarate + H(+) + NADPH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48182", "l": "(2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358791", "l": "Phosphorylation of USP8 by P-AKT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-981539", "l": "C3b binds to cell surface (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050505", "l": "hydroquinone glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51395", "l": "(9Z)-octadecenoyl-CoA + serotonin <=> CoA + H(+) + N-(9Z-octadecenoyl)-serotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.58", "l": "\"2-dehydro-3-deoxygalactonokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12089", "l": "an N-acylsphing-4-enine + UDP-alpha-D-glucose => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41058", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + dodecanoyl-CoA <=> 1,2-di-(9Z)-octadecenoyl-3-dodecanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71825", "l": "G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50309", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] => 11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36220", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56922", "l": "a medium-chain fatty acyl-AMP + diphosphate => a medium chain fatty acid + ATP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-452108", "l": "Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693086", "l": "BACE1(46-501) translocates from Golgi lumen to plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032399", "l": "HECT domain binding"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0009669", "l": "sucrose:cation symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31982", "l": "NADPH + O2 + trimethylamine <=> H2O + NADP(+) + trimethylamine N-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9613497", "l": "Unwinding DNA for the nascent transcript (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047463", "l": "2-aminohexano-6-lactam racemase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800315", "l": "MST1 binds MST1R (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928604", "l": "SFKs phosphorylate VAV2,3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59538", "l": "(2R)-ethylmalonyl-CoA + ADP + H(+) + phosphate => ATP + butanoyl-CoA + hydrogencarbonate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102778", "l": "Delta9-tetrahydrocannabinolate synthase activity"}, {"i": "MetaCyc:RXN-7854"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51384", "l": "hexadecanoyl-CoA + serotonin = CoA + H(+) + N-hexadecanoyl-serotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980067", "l": "NOTCH1 stimulates MYC transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12901", "l": "D-arginine + H2O = D-ornithine + urea"}, {"i": "EC:3.5.3.10", "l": "\"D-arginase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964531", "l": "TOP2A gene gene expression is repressed by the DREAM complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-453338", "l": "PGYM b dimer:AMP complex <=> PGYM dimer, b form + 2 AMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49797", "l": "an N-(fatty acyl)-glycine + H2O => a fatty acid + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52973", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] => a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47530", "l": "isocholate + NADP(+) => 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700181", "l": "Autophosphorylation of ALK fusions (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645694", "l": "p14ARF binds C1QBP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8873794", "l": "PCTP binds PC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28222", "l": "3-dehydro-L-gulonate + ATP = 3-dehydro-L-gulonate 6-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39708", "l": "a long-chain fatty acyl-CoA(out) => a long-chain fatty acyl-CoA(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851011", "l": "TRIM27 polyubiquitinates PTEN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65468", "l": "1-propanol + acetyl-CoA = CoA + propyl acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20237", "l": "(1S,4S)-5-oxo-1,2-campholide = [(1R)-2,2,3-trimethyl-2-oxocyclopent-3-en-1-yl]acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33103", "l": "(2E,6E)-farnesyl diphosphate = alpha-muurolene + diphosphate"}, {"i": "EC:4.2.3.125", "l": "\"Alpha-muurolene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35006", "l": "L-fucose(in) <=> L-fucose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19872", "l": "an acyl-CoA + glycine <=> an N-acylglycine + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809309", "l": "MTMR6 binds MTMR9 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683746", "l": "Protein 3a forms a homotetramer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45799", "l": "(3R)-3-hydroxybutanoyl-CoA + NADP(+) <=> acetoacetyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48547", "l": "[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine <=> [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49367", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + H(+) <=> 17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810376", "l": "ING2 binds PI5P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37294", "l": "H2O + L-alanyl-L-leucine <=> L-alanine + L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23181", "l": "a secondary alcohol + O2 => a ketone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39570", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21466", "l": "carbonyl sulfide + NH4(+) => 2 H(+) + H2O + thiocyanate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52798", "l": "Ni(2+) + sirohydrochlorin => 2 H(+) + Ni-sirohydrochlorin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54145", "l": "2 2-oxoglutarate + 5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 O2 => 5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 CO2 + H2O + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61520", "l": "AH2 + dopamine = 3-tyramine + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44829", "l": "(R)-carnitine + decanoyl-CoA => CoA + O-decanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22994", "l": "acetyl-CoA + CO2 + NADH => 3-oxopropanoate + CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806423", "l": "TP53 stimulates DDB2 expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801209", "l": "TP53 binds the TRIAP1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847537", "l": "RAB43:GTP binds USP8NL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186765", "l": "PLC-gamma binds to the active receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.98.-.-", "l": "\"Enzymes using H(2) as reductant\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018467", "l": "formaldehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34300", "l": "2'-deamino-2'-hydroxyneamine + 2-oxoglutarate => 2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59027", "l": "H2O + trihexadecanoylglycerol <=> dihexadecanoylglycerol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210271", "l": "Interaction of DAP12 and MDL-1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17032", "l": "(S)-allantoin + H2O <=> allantoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.184", "l": "\"UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolyzing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013109", "l": "RHOC GEFs activate RHOC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102304", "l": "sesquithujene synthase activity"}, {"i": "RHEA:31991", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + sesquithujene"}, {"i": "EC:4.2.3.102", "l": "\"Sesquithujene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41845", "l": "(3R)-hydroxyoctanoyl-[ACP] => (2E)-octenoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654545", "l": "Ligand-independent phosphorylation of overexpressed FGFR1c (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55935", "l": "3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O <=> AMP + H(+) + L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23439", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O <=> 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264865", "l": "Caspase-mediated cleavage of Lamin A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60256", "l": "A + H2O + N(6)-methyl-L-lysyl(4)-[histone H3] = AH2 + formaldehyde + L-lysyl(4)-[histone H3]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17236", "l": "L-fucose <=> L-fuculose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47454", "l": "(3S)-hydroxy-(5Z-tetradecenoyl)-CoA => (2E,5Z)-tetradecadienoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31458", "l": "NAD(+) + reduced riboflavin <=> 2 H(+) + NADH + riboflavin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102640", "l": "paspalinine synthase activity"}, {"i": "MetaCyc:RXN-15738"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42102", "l": "6''-O-carbamoylkanamycin A + AMP + diphosphate + H(+) + phosphate => ATP + carbamoyl phosphate + H2O + kanamycin A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18069", "l": "L-arginine = D-arginine"}, {"i": "EC:5.1.1.9", "l": "\"Arginine racemase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16479", "l": "15-oxoprostaglandin E1 + H(+) + NADH => NAD(+) + prostaglandin E1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59272", "l": "L-cysteine = D-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13199", "l": "H2O + UDP-alpha-D-6-sulfoquinovose => H(+) + sulfite + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "ic": "78.047734625335977", "identifiers": [{"i": "GO:0052866", "l": "phosphatidylinositol phosphate phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14174", "l": "dimethylallyl diphosphate + L-tryptophan => 4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9007447", "l": "E2F6 forms the PRC1L4 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70596", "l": "GOT2 dimer deaminates L-Asp (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114671", "l": "vWF binds to collagen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22374", "l": "3-oxopropanoate + H(+) + H2O2 + nitrite => H2O + O2 + propionate 3-nitronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9688832", "l": "MLKL binds PDCD6IP and SDCBP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944216", "l": "Association of procollagen type XV (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43631", "l": "L-serine + NAD(+) <=> aminoacetaldehyde + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29655", "l": "L-cysteine(in) = L-cysteine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19889", "l": "alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose"}, {"i": "EC:2.7.7.9", "l": "\"UTP--glucose-1-phosphate uridylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047291", "l": "lactosylceramide alpha-2,3-sialyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.26", "l": "\"Sterol O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63119", "l": "peroxynitrite <=> nitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44200", "l": "12-methyloctadecanoate + ATP + CoA = 12-methyloctadecanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157937", "l": "NICD3 traffics to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.159", "l": "\"Alpha-neoagaro-oligosaccharide hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928597", "l": "EPH:EFN dimers tetramerise (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41647", "l": "2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA <=> 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853792", "l": "RET tyrosine phosphorylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59338", "l": "AH2 + demethylspheroidene => 1-hydroxy-all-trans-1,2-dihydro-neurosporene + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70692", "l": "ornithine => putrescine + CO2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5140741", "l": "WNT5A binds FZD and ROR receptors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932765", "l": "NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10190", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+) => acetoacetyl-CoA + acetyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38698", "l": "a cardiolipin(in) <=> a cardiolipin(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140610", "l": "RNA sequestering activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663354", "l": "SLC26A5 (prestin) changes conformation in response to depolarization (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55721", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] => 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.2.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23630", "l": "a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43488", "l": "7(1)-hydroxychlorophyll a + NAD(+) = chlorophyll b + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781926", "l": "Defective PMM2 does not isomerise Man6P to Man1P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027281", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46707", "l": "ATP + H(+) + salicylate <=> 2-hydroxybenzoyl-5'-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14421", "l": "H2O + N(2)-benzoyl-D-arginine-4-nitroanilide = 4-nitroaniline + H(+) + N(2)-benzoyl-D-arginine"}, {"i": "EC:3.5.1.72", "l": "\"D-benzoylarginine-4-nitroanilide amidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56919", "l": "3beta-hydroxy-5alpha-androstan-17-one + NADP(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43101", "l": "S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) => 2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58683", "l": "A + FADH2 <=> AH2 + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004666", "l": "prostaglandin-endoperoxide synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814153", "l": "ADO oxidises 2AET to HTAU (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862184", "l": "USP48 cleaves polyubiquitin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43575", "l": "A + D-arginine + H2O <=> 5-guanidino-2-oxopentanoate + AH2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29982", "l": "2'-deoxyadenosine(in) + H(+)(in) <=> 2'-deoxyadenosine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60136", "l": "a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 = a (8S,9R)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64607", "l": "L-seryl-[protein] + UTP <=> diphosphate + uridylyl-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787820", "l": "IL34 dimer binds CSF1R (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240766", "l": "E2F1/2/3:DP1/2 binds SUZ12 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59407", "l": "L-homoserine <=> D-homoserine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20028", "l": "gibberellin A3 + UDP-alpha-D-glucose <=> gibberellin A3 O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657836", "l": "NR1H2,3 binds the ANGPTL3 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29651", "l": "agmatine(in) + L-arginine(out) = agmatine(out) + L-arginine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57355", "l": "O2 + reduced [NADPH--hemoprotein reductase] + zeinoxanthin <=> H(+) + H2O + lutein + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426160", "l": "SREBP1A,1C,2 binds the ACACA promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54834", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a jasmonyl-L-amino acid + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15346", "l": "ATP + L-arginine + L-tyrosine => AMP + diphosphate + H(+) + L-tyrosyl-L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77589", "l": "Recognition of AAUAAA sequence by CPSF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371591", "l": "Trimerization of cytosolic HSF1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47318", "l": "(2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797268", "l": "Expression of HMOX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14614", "l": "ATP + H2O + taurine(out) => ADP + H(+) + phosphate + taurine(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004581", "l": "dolichyl-phosphate beta-glucosyltransferase activity"}, {"i": "REACT:R-HSA-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19618", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65215", "l": "(2E)-dodecenoyl-CoA + H2O <=> (2E)-dodecenoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55278", "l": "9-cis-retinyl tetradecanoate + CoA => 9-cis-retinol + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14607", "l": "alpha,alpha-trehalose 6-phosphate + GDP + H(+) => D-glucose 6-phosphate + GDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53895", "l": "an S-prenyl-L-cysteine + H2O + O2 <=> a prenal + H2O2 + L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24217", "l": "(2E,6E)-farnesal + H2O + NAD(+) => (2E,6E)-farnesoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55378", "l": "2 a quinone + 2 H2O => 2 a quinol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40869", "l": "(2E,9E)-octadecadienoyl-CoA + FADH2 => (9E)-octadecenoyl-CoA + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015538", "l": "sialic acid:proton symporter activity"}, {"i": "REACT:R-HSA-5624239", "l": "Defective SLC17A5 does not cotransport Neu5Ac, H+ from lysosomal lumen to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53830", "l": "a 5-formyl-2'-deoxycytidine in DNA + CO2 + H2O + succinate => 2-oxoglutarate + a 5-hydroxymethyl-2'-deoxycytidine in DNA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52959", "l": "hyodeoxycholate + UDP-alpha-D-glucuronate <=> hyodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684261", "l": "nsp4 is glycosylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202174", "l": "Activation of ZAP-70 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54012", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31898", "l": "(2E,6E)-farnesyl diphosphate <=> (1E,4E,8E)-alpha-humulene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183055", "l": "Binding of CBL to EGFR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28961", "l": "D-xylose(out) + H(+)(out) => D-xylose(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3858482", "l": "DVL is recruited to the receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174171", "l": "Association of Cyclin A with the APC/C (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16153", "l": "an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29652", "l": "agmatine(in) + L-arginine(out) => agmatine(out) + L-arginine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018763", "l": "hydroxydechloroatrazine ethylaminohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21507", "l": "acetoin + aldehydo-D-ribose 5-phosphate <=> 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14449", "l": "chlorophyllide a + NADP(+) = 3,8-divinyl chlorophyllide a + H(+) + NADPH"}, {"i": "RHEA:48884", "l": "NADP(+) + protochlorophyllide a = 3,8-divinyl protochlorophyllide a + H(+) + NADPH"}, {"i": "EC:1.3.1.75", "l": "\"3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54690", "l": "2-aminoprop-2-enoate + allylsulfenate => alliin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64030", "l": "H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine => 3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8)-citryl-spermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60385", "l": "enterobactin + H2O => N-(2,3-dihydroxybenzoyl)-L-serine trimer"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033782", "l": "24-hydroxycholesterol 7alpha-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37052", "l": "3-deacetyl-3-vinylbacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate => ATP + chlorophyllide a + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36464", "l": "glycyl-L-glutamate + H2O => glycine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24081", "l": "ATP + L-tryptophan + tRNA(Trp) => AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.22", "l": "\"Alpha-galactosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2197698", "l": "Src phosphorylate WASP,N-WASP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43687", "l": "ATP + L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphate <=> AMP + diphosphate + H(+) + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54729", "l": "acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] => malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20674", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690196", "l": "USP8 deubiquitinates RNF128 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11658", "l": "AMP + diphosphate + L-prolyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849428", "l": "PTPN1 binds PTK6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162096", "l": "carbovir diphosphate + ATP => carbovir triphosphate + ADP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27420", "l": "2 [Fe(III)cytochrome] + H2O + nicotinate <=> 6-hydroxynicotinate + 2 [Fe(II)cytochrome] + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47065", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9679044", "l": "FKBP1A binds sirolimus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60772", "l": "2 2-oxoglutarate + gibberellin A12 + H(+) + 3 O2 = 3 CO2 + gibberellin A9 + 2 H2O + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45000", "l": "(R)-carnitine + 3-hydroxybutanoyl-CoA = CoA + O-3-hydroxybutanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112379", "l": "Recruitment of elongation factors to form elongation complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175117", "l": "1-LTR circle formation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005111", "l": "type 2 fibroblast growth factor receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28947", "l": "H(+)(out) + L-arabinose(in) = H(+)(in) + L-arabinose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19121", "l": "an S-substituted glutathione(in) + ATP + H2O = ADP + an S-substituted glutathione(out) + H(+) + phosphate"}, {"i": "EC:7.6.2.3", "l": "\"ABC-type glutathione-S-conjugate transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194678", "l": "CYP51A1 demethylates LNSOL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2429719", "l": "MCPH1 sequesters condensin II (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11428", "l": "beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60839", "l": "a 5'-end diphospho-adenosine in mRNA + GTP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51389", "l": "acetyl-CoA + dopamine => CoA + H(+) + N-acetyl-dopamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57326", "l": "CoA + H(+) + N-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein] => acetyl-CoA + N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49877", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5625416", "l": "Anterograde IFT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36417", "l": "diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167234", "l": "Association of Tat with P-TEFb(Cyclin T1:Cdk9) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.1", "l": "\"Leucyl aminopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21732", "l": "chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate"}, {"i": "EC:4.1.3.27", "l": "\"Anthranilate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13986", "l": "ATP + L-homoserine => ADP + H(+) + O-phospho-L-homoserine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45764", "l": "H2O + L-aspartate 4-semialdehyde + NAD(+) = 2 H(+) + L-aspartate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23553", "l": "2-methylpropane-1,2-diol + NAD(+) => 2-hydroxy-2-methylpropanal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380272", "l": "Plk1-mediated phosphorylation of Nlp (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35625", "l": "D-gamma-glutamyl-D-glutamate + NH4(+) => D-glutamate + D-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70475", "l": "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52938", "l": "(3S)-hydroxy-3-methylglutaryl-[ACP] + H(+) + holo-[ACP] => 3-oxobutanoyl-[ACP] + acetyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60148", "l": "(L-glutamyl)n-L-gamma-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate = (L-glutamyl)n+1-L-gamma-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9691174", "l": "RAC1 binds effectors at the ER membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0010857", "l": "calcium-dependent protein kinase activity"}, {"i": "REACT:R-HSA-8986937", "l": "MECP2 is phosphorylated at T308 (Homo sapiens)"}, {"i": "REACT:R-HSA-9005561", "l": "Active PKA, CaMK IV do not phosphorylate MECP2 mutants R306C,(R306H) at T308 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65230", "l": "H(+) + NADPH + naphthalene-1,2-diol => (1S,2S)-1,2-dihydronaphthalene-1,2-diol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57319", "l": "ATP + cytidine 5'-diphosphoramidate <=> ADP + cytidine 3'-phospho-5'-diphosphoramidate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21275", "l": "ATP + glutathione + spermidine <=> ADP + glutathionylspermidine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21842", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53159", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(5,6-epoxy-8Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55007", "l": "1-hydroxylimonen-2-one + NADPH + O2 <=> 3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46954", "l": "2 CO2 + H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin] => 2 formate + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.n3", "l": "\"Curcumin reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.129"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23436", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O = 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201521", "l": "ALK autophosphorylation downstream of PTN and MDK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374662", "l": "Translocation of Ezrin to plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16870", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-448963", "l": "Interaction of MyoD:E protein with MEF2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578712", "l": "Importin-8 binds AGO2:miRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56451", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250280", "l": "ROS oxidize thioredoxin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002151", "l": "G-quadruplex RNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807872", "l": "Active ARF recruits coatomer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031896", "l": "PD1n-3, PD2n-3 translocate from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66630", "l": "(2S,4S)-2-amino-4-[(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]-4-hydroxybutanoyl-[peptidyl-carrier protein] + H2O2 => (2S,4S,5S)-2-amino-6-(3,4-dihydroxyphenyl)-4-hydroxy-5-(methylamino)hexanoyl-[peptidyl-carrier protein] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043741", "l": "alpha-aminoadipate acetyltransferase activity"}, {"i": "MetaCyc:RXN-5181"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13395", "l": "5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate => diphosphate + nicotinate beta-D-ribonucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983424", "l": "Budding of COPII coated vesicle (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59242", "l": "L-homoarginine + L-ornithine => L-arginine + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607737", "l": "BCL10 oligomerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018818", "l": "acetylene hydratase activity"}, {"i": "RHEA:17885", "l": "acetaldehyde = acetylene + H2O"}, {"i": "EC:4.2.1.112", "l": "\"Acetylene hydratase\""}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0140033", "l": "acetylation-dependent protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.15", "l": "\"Thimet oligopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34822", "l": "dihydrocurcumin + NADP(+) <=> curcumin + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27881", "l": "2',3'-cyclic UMP + H2O <=> 3'-UMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29589", "l": "2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH => 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050337", "l": "thiosulfate-thiol sulfurtransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371590", "l": "HSP70 binds to HSP40:nascent protein (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013110", "l": "RHOC binds effectors at the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34513", "l": "H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP => N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20908", "l": "3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP"}, {"i": "EC:2.4.1.225", "l": "\"N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380311", "l": "Recruitment of Plk1 to centrosomes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17920", "l": "[Glu(-Cys)](n)-Gly + glutathione + H(+) <=> [Glu(-Cys)](n+1)-Gly + glycine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008117", "l": "sphinganine-1-phosphate aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58390", "l": "4-amino-3-all-trans-hexaprenylbenzoate + diphosphate => 4-aminobenzoate + all-trans-hexaprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645220", "l": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52654", "l": "24-methylene-24-dihydrolanosterol + H(+) + S-adenosyl-L-homocysteine => lanosterol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19176", "l": "H(+) + NADH + naphthalene + O2 <=> (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809680", "l": "MTMR12 binds MTM1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432067", "l": "Aquaporin-4 passively transports water out of cell (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015039", "l": "NADPH-adrenodoxin reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36635", "l": "4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.282", "l": "\"tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33080", "l": "6-amino-6-deoxyfutalosine + H2O => adenine + dehypoxanthine futalosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64392", "l": "a dipeptide(out) + H(+)(out) = a dipeptide(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14971", "l": "(E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + trans-aconitate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14601", "l": "L-lysine + O2 = 5-aminopentanamide + CO2 + H2O"}, {"i": "EC:1.13.12.2", "l": "\"Lysine 2-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65711", "l": "alpha-D-mannose 1-phosphate + GDP-beta-L-galactose <=> beta-L-galactose 1-phosphate + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863471", "l": "LDLR is bound by DAB2 and ARH (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951676", "l": "RUNX3 binds TEADs and YAP1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218811", "l": "DOCK180:ELMO binds CRK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34791", "l": "2-hydroxyethylphosphonate + O2 = formate + H(+) + hydroxymethylphosphonate"}, {"i": "EC:1.13.11.72", "l": "\"2-hydroxyethylphosphonate dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10906", "l": "AH2 + C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen sulfide => [cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1362465", "l": "GHBP binds GHR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202472", "l": "Translocation of TRAF6 to CBM complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1369052", "l": "ABCAs mediate lipid influx (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.124"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37912", "l": "(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41349", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033265", "l": "choline binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350362", "l": "ROK phosphorylates MBS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685606", "l": "CLEC2D binds KLRB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48193", "l": "(9E)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,9E)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12946", "l": "2'-hydroxybiphenyl-2-sulfinate + H2O => biphenyl-2-ol + H(+) + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27414", "l": "2-oxoglutarate + codeine + O2 => CO2 + formaldehyde + morphine + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39591", "l": "(3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA = (2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34210", "l": "3-O-alpha-D-glucosyl-L-rhamnose + phosphate <=> beta-D-glucose 1-phosphate + L-rhamnopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59440", "l": "(-)-dehydrodiconiferyl alcohol + H(+) + NADPH = (S)-isodihydrodehydrodiconiferyl alcohol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20187", "l": "an N-acylneuraminate + CMP + H(+) => a CMP-N-acyl-beta-neuraminate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17562", "l": "acetylcholine + H2O => acetate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56854", "l": "H(+) + S-adenosyl-L-homocysteine + toxoflavin => reumycin + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050244", "l": "pyruvate oxidase (CoA-acetylating) activity"}, {"i": "KEGG.REACTION:R00211"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34162", "l": "acetyl-CoA + UDP-N-acetylbacillosamine <=> CoA + H(+) + UDP-N,N'-diacetylbacillosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47467", "l": "(3E,5Z)-tetradecadienoyl-CoA <=> (2E,5Z)-tetradecadienoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66372", "l": "H2O + sn-glycerol 3-phosphate = glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19147", "l": "D-glucose + H(+) + sulfate => D-glucose 6-sulfate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11116", "l": "acetyl-CoA + an alkane-alpha,omega-diamine = an N-acetylalkane-alpha,omega-diamine + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23274", "l": "an N(6)-alkylamino-7-beta-D-glucosylpurine + H(+) + UDP => an N(6)-alkylaminopurine + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62279", "l": "3 (R)-2-hydroxy-3-methylbutyrate + 6 ATP + 3 L-phenylalanine + 3 S-adenosyl-L-methionine <=> 6 AMP + beauvericin + 6 diphosphate + 6 H(+) + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65693", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine => a diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32387", "l": "dihydrocarveol + NAD(+) = dihydrocarvone + H(+) + NADH"}, {"i": "EC:1.1.1.296", "l": "\"Dihydrocarveol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36318", "l": "2 H(+) + hexadecanoyl-CoA + 2 NADPH <=> CoA + hexadecan-1-ol + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106347", "l": "U2 snRNA 2'-O-methyladenosine m6 methyltransferase activity"}, {"i": "RHEA:62672", "l": "a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-O-methyladenosine in U2 snRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "78.047734625335977", "identifiers": [{"i": "GO:0016417", "l": "S-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018747", "l": "RHOQ GEFs activate RHOQ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203613", "l": "depalmitoylation of eNOS (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41341", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 => 10R-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047040", "l": "pteridine reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61656", "l": "(2E,6E)-farnesol + ATP = (2E,6E)-farnesyl phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29837", "l": "D-galactonate(out) + H(+)(out) => D-galactonate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45107", "l": "6-demethylmitomycin A + S-adenosyl-L-methionine <=> mitomycin A + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28675", "l": "alpha-D-galactose = beta-D-galactose"}, {"i": "EC:5.1.3.3", "l": "\"Aldose 1-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264679", "l": "Serum albumin binds 2-lysophosphatidylcholine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.99.-", "l": "\"Acting on other compounds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57462", "l": "4-O-(beta-D-glucosyl)-trans-4-sinapoyl alcohol + H(+) + UDP => (E)-sinapoyl alcohol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72631", "l": "Formation of the cap-binding eIF4F complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54054", "l": "diphosphate + tau-cadinol => (2E,6E)-farnesyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66610", "l": "GpCpCpA + H(+) + tRNA 3'-end (3'-phosphooxy-ribonucleotide) => (tRNA)-3'-end (ribonucleoside 5'-phosphate)-(guanosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(adenosine 5'-phosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2993802", "l": "HLCS biotinylates PC:Mn2+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102876", "l": "psoralen synthase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004745", "l": "NAD-retinol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12790", "l": "an alditol + NADP(+) => an aldose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "68.973118714897424", "identifiers": [{"i": "GO:0016763", "l": "pentosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2272795", "l": "Interaction of DAP12 and KIR2DS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5632677", "l": "PTCH is internalized (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130349", "l": "Generation of CLIP from lip10 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29662", "l": "O-acetyl-L-serine(in) <=> O-acetyl-L-serine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3234081", "l": "SUMOylation of TFAP2A with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.35", "l": "\"Gelatinase B\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209220", "l": "Liberation of CI from SU(FU) repression (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173709", "l": "C7 binds C5b:C6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13014", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose => an alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36273", "l": "formaldehyde + H2O + NADP(+) + theobromine => caffeine + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781922", "l": "USP13 binds UFD1L:SKP2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380930", "l": "Phosphorylated AMPK binds AMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61143", "l": "(2R,3R)-dihydromyricetin + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + myricetin + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018113", "l": "lysine racemase activity"}, {"i": "MetaCyc:LYSINE-RACEMASE-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042898", "l": "fosmidomycin transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25919", "l": "A + H2O + quinolin-6-ol <=> 6-hydroxyquinolin-2(1H)-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39350", "l": "(2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADPH <=> (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37204", "l": "(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950766", "l": "IL27RA dimerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48024", "l": "1,2,3-tripropanoylglycerol + H2O = dipropanoylglycerol + H(+) + propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65031", "l": "(+)-pinoresinol + H2O + 2 oxidized [azurin] <=> (+)-6-hydroxypinoresinol + 2 H(+) + 2 reduced [azurin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2467775", "l": "Autocleavage of ESPL1 (Separase) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1470073", "l": "Peroxynitrite enters the bacterium (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685953", "l": "SIRT6 deacetylates RBBP8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033852", "l": "thyroid-hormone transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199050", "l": "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30870", "l": "H2O + indole-3-acetaldehyde + NAD(+) <=> (indol-3-yl)acetate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22302", "l": "a flavonol 3-O-beta-D-glucoside + H(+) + UDP => a flavonol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37230", "l": "(E,E)-sorbate + H(+) <=> (E)-1,3-pentadiene + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392187", "l": "Activated P2Y purinoceptor 12 binds G-protein Gi (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61390", "l": "ADP + biotin(out) + H(+) + phosphate => ATP + biotin(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428917", "l": "G13 activation by TP receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375160", "l": "NCAM1 binds to ATP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112690", "l": "PTPN11 binds CBL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848087", "l": "STAP2 recruits STAT3 to PTK6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38007", "l": "6-geranylgeranyl-2-methylbenzene-1,4-diol + S-adenosyl-L-methionine = 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40269", "l": "3-oxohexadecanedioyl-CoA + H(+) + NADH => (3S)-hydroxyhexadecanedioyl-CoA + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052809", "l": "acharan sulfate lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250280", "l": "ROS oxidize thioredoxin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-947531", "l": "Molybdenum ion transfer onto molybdopterin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615937", "l": "TPNO/KPNB1 (transportin/importin beta) sequester the Nup107-160 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16560", "l": "2-amino-3-carboxymuconate 6-semialdehyde + H(+) <=> 2-aminomuconate 6-semialdehyde + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31324", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP-alpha-D-mannose => (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.21"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23549", "l": "guanosine(966) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804652", "l": "UACA binds apoptosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46458", "l": "5alpha-cholest-8-en-3beta-ol + NADP(+) => 5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417896", "l": "P2Y6 receptor can bind to UDP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.42", "l": "\"Homomethionine N-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53017", "l": "chlorohydroquinone + 2 glutathione => chloride + glutathione disulfide + H(+) + hydroquinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14141", "l": "AMP + glutathione disulfide + 2 H(+) + sulfite = adenosine 5'-phosphosulfate + 2 glutathione"}, {"i": "EC:1.8.4.9", "l": "\"Adenylyl-sulfate reductase (glutathione)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28661", "l": "beta-D-galactose + beta-D-glucose => beta-lactose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3204303", "l": "MRE11 binds cytosolic DNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38706", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061666", "l": "UFM1 ligase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0140475", "l": "spindle pole body anchor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879942", "l": "The receptor is activated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60388", "l": "Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O = Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-451418", "l": "Pellino ubiquitinates IRAK1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56804", "l": "2 cob(II)yrinate a,c diamide--[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] = 2 cob(I)yrinate a,c diamide--[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30437", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + tRNA(Gly) => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + glycyl-tRNA(Gly)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50708", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43705", "l": "ATP + H(+) + tetradecanoate => diphosphate + tetradecanoyl-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22312", "l": "5-(methylsulfanyl)-D-ribose + ATP = ADP + H(+) + S-methyl-5-thio-alpha-D-ribose 1-phosphate"}, {"i": "EC:2.7.1.100", "l": "\"S-methyl-5-thioribose kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53902", "l": "ADP + H(+) + O-phospho-L-threonyl-[myosin light chain] => ATP + L-threonyl-[myosin light chain]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58919", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + squalene <=> (S)-2,3-epoxysqualene + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12844", "l": "pyridoxamine + pyruvate <=> L-alanine + pyridoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806610", "l": "Keratin filament formation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5684096", "l": "CDK2 phosphorylates RBBP8 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.11", "l": "\"2-haloacid dehalogenase (configuration-retaining)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009026", "l": "tagaturonate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30109", "l": "2-aminomalonate semialdehyde + H(+) + NADPH => D-serine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42862", "l": "1,2-dioctanoyl-sn-glycerol + phosphate => 1,2-dioctanoyl-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430190", "l": "p-SLP-76 binds NCK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70272", "l": "PGM:Mg2+ isomerise G6P to G1P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033890", "l": "ribonuclease D activity"}, {"i": "MetaCyc:3.1.13.5-RXN"}, {"i": "EC:3.1.13.5", "l": "\"Ribonuclease D\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018708", "l": "thiol S-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "54.608349956968048", "identifiers": [{"i": "GO:0004497", "l": "monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2002466", "l": "Formation of allysine by LOX (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004576", "l": "oligosaccharyl transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30371", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O = (-)-geosmin + acetone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420131", "l": "The PACAP receptor binds PACAP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351913", "l": "Caspase-mediated cleavage of TJP1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938217", "l": "RUNX1 binds the SWI/SNF complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086410", "l": "CDK1 phosphorylates BORA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004851", "l": "uroporphyrin-III C-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031853", "l": "nociceptin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57359", "l": "2-oxoglutarate + chloride + H(+) + hapalindole U + O2 <=> CO2 + H2O + hapalindole G + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247836", "l": "Retromer recycles WLS to the Golgi (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24776", "l": "H2O + pheophorbide a = C-13(2)-carboxypyropheophorbide a + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44158", "l": "myo-inositol + phosphate => 1D-myo-inositol 5-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140616", "l": "iodotyrosine deiodinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45966", "l": "2 AMP + ATP + 2 H(+) => 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83793", "l": "Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614614", "l": "Cysteine is degraded to serine and H2S (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382057", "l": "Release of novel PDGFs as latent factors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2430535", "l": "MASTL phosphorylates ENSA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987007", "l": "p-STAT1 dimerizes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38852", "l": "H(+) + tetracenomycin F2 => H2O + tetracenomycin F1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002083", "l": "4-hydroxybenzoate decaprenyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54432", "l": "2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 = a 4-H-anthocyanidin with a 3-hydroxy group + CO2 + 2 H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49558", "l": "H(+) + L-cysteinyl-[protein] + lactate => H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9692880", "l": "HRH3 binds Hist (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14395", "l": "3 H(+) + N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine => N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65233", "l": "3-hydroxydodecanoyl-CoA + H2O => 3-hydroxydodecanoate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73797", "l": "FAICAR => IMP + H2O (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23870", "l": "acetyl-CoA + cyclohexanone => (1-hydroxycyclohexan-1-yl)acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11183", "l": "ATP + L-asparagine + tRNA(Asn) <=> AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.23"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27719", "l": "H2O + IMP => inosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605724", "l": "Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380042", "l": "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50426", "l": "prostaglandin G1 => (8Z,11Z,14Z)-eicosatrienoate + 2 O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018121", "l": "NAD(P)-asparagine ADP-ribosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15954", "l": "agmatine + ATP => ADP + 2 H(+) + N(4)-phosphoagmatine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50636", "l": "a 3-(omega-methylsulfanyl)alkylmalate = a 2-(omega-methylsulfanyl)alkylmaleate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874083", "l": "p-Y397-PTK2 binds SRC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10752", "l": "[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n ATP + n D-aspartate = [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n H(+) + n phosphate"}, {"i": "EC:6.3.1.12", "l": "\"D-aspartate ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981622", "l": "Myoglobin:oxygen dissociates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41574", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH => lipoxin A4 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17155", "l": "CDP-4-dehydro-6-deoxy-D-glucose + H2O => CDP-D-glucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099620", "l": "UDP-4-amino-4-deoxy-L-arabinose aminotransferase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13641", "l": "H(+) + methane + NADPH + O2 = H2O + methanol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16208", "l": "H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] <=> N(6)-(D-fructosyl)-L-lysyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24781", "l": "C-13(2)-carboxypyropheophorbide a + H(+) => CO2 + pyropheophorbide a"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20095", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP => an anthocyanidin + H(+) + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21337", "l": "NAD(+) + pyridoxal => 4-pyridoxolactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48110", "l": "2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine => L-arginyl-[protein] + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62908", "l": "nor-toralactone + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + toralactone"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008108", "l": "UDP-glucose:hexose-1-phosphate uridylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015418", "l": "ABC-type quaternary ammonium compound transporting activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109701", "l": "PDPK1 binds PIP3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72697", "l": "Start codon recognition (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36177", "l": "1-O-alkyl-sn-glycero-3-phosphate + NADP(+) => 1-O-alkylglycerone 3-phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192061", "l": "CYP46A1 24-hydroxylates CHOL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70596", "l": "GOT2 dimer deaminates L-Asp (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49317", "l": "beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (5R,6S)-5,6-epoxi-beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54649", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63775", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388560", "l": "EDNRA,EDNRB bind EDNs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56627", "l": "2,4,5-trichlorocyclohexa-2,5-dien-1-ol + H2O <=> 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + chloride + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14953", "l": "H(+) + NADPH + O2 + tetradecanoyl-CoA = (11Z)-tetradecenoyl-CoA + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50583", "l": "acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35617", "l": "H(+) + methylglyoxal + NADH => hydroxyacetone + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30449", "l": "formaldehyde + H2O + NAD(+) + xanthine => 3-methylxanthine + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2130706", "l": "MHC class II antigen processing (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694421", "l": "PP6 dephosphorylates SEC24 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634228", "l": "TRAF1 is cleaved by caspases (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43327", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448603", "l": "IL33:IL1RL1 binds IL1RAP-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31955", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-dien-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707505", "l": "Hemes bind to CLEC1B dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-532603", "l": "Nephrin mediated activation of N-WASP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37626", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382053", "l": "Translocation of PDGF from ER to Golgi (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450533", "l": "PKCdelta phosphorylates HuR (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50021", "l": "decanoyl-CoA + H2O => adenosine 3',5'-bisphosphate + decanoyl-4'-phosphopantetheine + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53625", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + tsukubadiene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-984606", "l": "Kinesin-5 is a homotetramer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54951", "l": "(3R)-hydroxy-(5Z)-dodecenoyl-[ACP] <=> (2E,5Z)-dodecadienoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26559", "l": "(3S)-3-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18726", "l": "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA => acetyl-CoA + vanillin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42367", "l": "2 a 2-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37746", "l": "dimethylallyl phosphate + FMNH2 <=> phosphate + prenyl-FMNH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5663050", "l": "DHI and DHICA polymerise forming eumelanin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8862380", "l": "HSD17B13 binds lipid droplets (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635839", "l": "ULK3:SUFU dissociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174203", "l": "SCF-mediated degradation of Emi1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24972", "l": "calcitetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051059", "l": "NF-kappaB binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676598", "l": "TRAF2:cIAP1/2 complex binds FN14:TWEAK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17495", "l": "AH2 + dihydroxyacetone => A + glycerol"}]}
{"type": "biolink:MolecularActivity", "ic": "77.690207805941611", "identifiers": [{"i": "GO:0008188", "l": "neuropeptide receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19017", "l": "(6S)-NADHX + ATP = ADP + H(+) + NADH + phosphate"}, {"i": "RHEA:32231", "l": "(6S)-NADPHX + ATP = ADP + H(+) + NADPH + phosphate"}, {"i": "EC:4.2.1.93", "l": "\"ATP-dependent NAD(P)H-hydrate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018798", "l": "RHOV binds GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10763", "l": "citrate <=> acetate + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73718", "l": "UBF-1 Binds rDNA Promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14865", "l": "S-adenosyl-L-methionine + tyramine = H(+) + N-methyltyramine + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.27", "l": "\"Tyramine N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008508", "l": "bile acid:sodium symporter activity"}, {"i": "REACT:R-HSA-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59587", "l": "ATP + beta-alanine + L-lysine <=> ADP + beta-alanyl-L-lysine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20312", "l": "2 H2O2 <=> 2 H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49541", "l": "(2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate => (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54044", "l": "(2E,6E)-farnesyl diphosphate + H2O = 7-epi-alpha-eudesmol + diphosphate"}, {"i": "EC:4.2.3.169", "l": "\"7-epi-alpha-eudesmol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39136", "l": "(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + O2 => (2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13374", "l": "H2O + L-mimosine => 3-hydroxy-4H-pyrid-4-one + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37625", "l": "a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021953", "l": "GAMT gene expression is stimulated by MECP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12942", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33360", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37090", "l": "[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine <=> 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57617", "l": "dihydro-ML-236C-[compactin nonaketide synthase] + H2O => dihydro-ML-236C carboxylate + H(+) + holo-[compactin nonaketide synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940100", "l": "CDK1 phosphorylates VCPIP1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36838", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140806", "l": "SERPINC1 binds SERPINC1 activators (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2730835", "l": "Autophosphorylation of PKC-theta (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43729", "l": "methyl (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + juvenile hormone III + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40145", "l": "(9Z,12Z)-octadecadienoate + CoA + H(+) => (9Z,12Z)-octadecadienoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13951", "l": "NADPH + 2 oxidized [rubredoxin] => H(+) + NADP(+) + 2 reduced [rubredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53118", "l": "an 11-oxosteroid + H(+) + NADH => an 11beta-hydroxysteroid + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50347", "l": "3 (S)-methylmalonyl-CoA + a long-chain fatty acyl-CoA + 9 H(+) + holo-[mycolipanoate synthase] + 6 NADPH <=> 3 CO2 + 4 CoA + 3 H2O + long-chain mycolipanoyl-[mycolipanoate synthase] + 6 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65100", "l": "a 1-acylglycerol + hexadecanoyl-CoA = an hexadecanoyl-acylglycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004619", "l": "phosphoglycerate mutase activity"}, {"i": "MetaCyc:3PGAREARR-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11446", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate => 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20579", "l": "aminohydroquinone => 3-hydroxyaminophenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018798", "l": "RHOV binds GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24532", "l": "2-methylbutanoyl-CoA + NAD(+) = 2-methylbut-2-enoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0019870", "l": "potassium channel inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28627", "l": "O2 + reduced [NADPH--hemoprotein reductase] + solavetivol = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + solavetivone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432164", "l": "Ca2+ influx into the post-synaptic cell (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49023", "l": "2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167686", "l": "Active PLCG1 hydrolyses PIP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40637", "l": "2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) + hexadecanoate => 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426148", "l": "SREBP1A,1C binds the FASN promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44194", "l": "2-methylhexadecanoyl-CoA + AMP + diphosphate => 2-methylhexadecanoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113446", "l": "Initiation of RNA Polymerase III Productive Transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48485", "l": "a propanoate ester + H2O => an aliphatic alcohol + H(+) + propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654422", "l": "Activated FGFR4 binds FRS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61140", "l": "(2R,3R)-dihydromyricetin + 2-oxoglutarate + O2 = CO2 + H(+) + H2O + myricetin + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814298", "l": "Late envelope proteins bind cornified envelope:CDSN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37080", "l": "2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine => 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42422", "l": "(4R)-4-hydroxy-L-lysine + CO2 + succinate => 2-oxoglutarate + L-lysine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19954", "l": "a 2-oxocarboxylate + L-alanine => an L-alpha-amino acid + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51489", "l": "archaetidylserine + H(+) => archaetidylethanolamine + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36934", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 <=> (9Z)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63932", "l": "abscisate(in) + ATP + H2O = abscisate(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5692779", "l": "p-S182 MAPKAPK5 phosphorylates FOXO1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17308", "l": "H2O + N(omega),N(omega)-dimethyl-L-arginine <=> dimethylamine + L-citrulline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.3.3", "l": "\"Lysine 5,6-aminomutase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53609", "l": "4-hydroxyestrone + O2 => (2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33387", "l": "cadaverine + S-adenosyl 3-(methylsulfanyl)propylamine = aminopropylcadaverine + H(+) + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139898", "l": "Caspase-8 activates BID by cleavage (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34713", "l": "15-methylhexadecasphing-4-enine + a fatty acid => H2O + N-acyl-15-methylhexadecasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16796", "l": "H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine <=> CO2 + D-pantetheine 4'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196773", "l": "COASY phosphorylates DP-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12761", "l": "precorrin-3B + S-adenosyl-L-methionine = 3 H(+) + precorrin-4 + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.131", "l": "\"Precorrin-3B C(17)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60199", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(9)-[histone H3] + O2 <=> CO2 + formaldehyde + L-lysyl(9)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618811", "l": "Calcium binds calmodulin at the synapse (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694462", "l": "ABHD6,12 hydrolyse 3AG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48327", "l": "ganglioside GD1b + GDP-beta-L-fucose <=> ganglioside Fuc-GD1b + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0034639", "l": "L-amino acid efflux transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17954", "l": "3-hydroxyanthranilate + O2 => (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035888", "l": "isoguanine deaminase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034529", "l": "2-hydroxy-3-carboxy-benzalpyruvate hydratase-aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173626", "l": "Activation of C1r (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707523", "l": "Hemes bind to BACH1:MAFK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169895", "l": "Crk's SH3 domain engages C3G (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198513", "l": "Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24977", "l": "(1S)-1,25-dihydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16814", "l": "H2O + L-kynurenine => anthranilate + H(+) + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173542", "l": "SMURF2 ubiquitinates SMAD2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102549", "l": "1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity"}, {"i": "MetaCyc:RXN-14912"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62823", "l": "1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13995", "l": "2-methyl-3-oxopropanoate + L-glutamate => (S)-3-amino-2-methylpropanoate + 2-oxoglutarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45530", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14506", "l": "2 glutathione + thiosulfate => glutathione disulfide + 2 H(+) + hydrogen sulfide + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52401", "l": "4-O-phospho-D-threonate + NAD(+) => 3-dehydro-4-O-phospho-L-erythronate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10722", "l": "6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione => 2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60849", "l": "a 5'-end diphospho-guanosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] => a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53588", "l": "NAD(+) + resolvin D2 = 16-oxoresolvin D2 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77068", "l": "Activation of GT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174124", "l": "Dephosphorylation of phospho-Cdh1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16842", "l": "precorrin-2 + S-adenosyl-L-methionine => H(+) + precorrin-3A + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15880", "l": "2-oxoglutarate + pyridoxamine 5'-phosphate <=> D-glutamate + pyridoxal 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20232", "l": "2,3-dihydroxybenzoate + ATP + H(+) <=> 2,3-dihydroxybenzoyl-5'-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10046", "l": "cyclohexanone + H(+) + NADH => cyclohexanol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54961", "l": "ATP + CoA + dinor-OPDA => AMP + dinor-OPDA-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35536", "l": "cyclo(L-phenylalanyl-L-leucyl) + O2 => cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16626", "l": "acetyl-CoA + hydrogen sulfide => CoA + thioacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39502", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA <=> (2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007882", "l": "IL1F10 is cleaved (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54180", "l": "a long-chain fatty aldehyde + holo-[ACP] + NAD(+) = a long-chain fatty acyl-[ACP] + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048258", "l": "3-ketoglucose-reductase activity"}, {"i": "MetaCyc:KETOGLUCOSE-REDUCTASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45866", "l": "4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA => 16-hydroxyhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23345", "l": "a purine D-ribonucleoside + H2O => a purine nucleobase + D-ribose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62710", "l": "4-(indol-3-yl)butanoyl-beta-D-glucose + UDP => (indol-3-yl)butanoate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52607", "l": "3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-seryl-[protein] + ATP <=> 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-seryl-[protein] + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5660666", "l": "CBP and p300 binds NF-kB complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46662", "l": "5beta-pregnan-3,20-dione + NADP(+) => H(+) + NADPH + progesterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22988", "l": "3-oxopropanoate + CoA + NADP(+) = acetyl-CoA + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28659", "l": "beta-lactose + H2O = beta-D-galactose + beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4341072", "l": "SUMOylation of RARA with SUMO2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139906", "l": "Activation of BAD by calcineurin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23613", "l": "1,2-dihydro-alpha-santonin + NAD(+) => alpha-santonin + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:1901683", "l": "arsenate ion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39461", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+) => (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15817", "l": "H2O + O2 + pyridoxamine 5'-phosphate = H2O2 + NH4(+) + pyridoxal 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-981713", "l": "C4b binds to cell surface (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.3", "l": "\"Haloacetate dehalogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47364", "l": "a dodecanoate ester + H2O = an aliphatic alcohol + dodecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8955844", "l": "RBKS phosphorylates ribose to R5P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34144", "l": "cannabinerolate + O2 => Delta(9)-tetrahydrocannabinolate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-877281", "l": "PIAS1 binds p-STAT1 dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16485", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazole-4-acetate = 1-(5-phosphoribosyl)imidazole-4-acetate + ADP + diphosphate + H(+) + phosphate"}, {"i": "EC:6.3.4.8", "l": "\"Imidazoleacetate--phosphoribosyldiphosphate ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35775", "l": "L-glutamine + UDP-3-oxo-alpha-D-glucose = 2-oxoglutaramate + UDP-alpha-D-kanosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56472", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 = (5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66997", "l": "2-methylpentanoate + ATP + CoA => 2-methylpentanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18238", "l": "2,5-dihydroxybenzoate + O2 => 3-maleylpyruvate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60511", "l": "a guanosine in mRNA + S-adenosyl-L-methionine <=> an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42117", "l": "5alpha-androstane-3alpha,17beta-diol + NADP(+) => 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102266", "l": "tRNA-dihydrouridine20a synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41057", "l": "1,2-di-(9Z)-octadecenoyl-3-dodecanoyl-sn-glycerol + CoA => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + dodecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38868", "l": "uridine(516) in 16S rRNA => pseudouridine(516) in 16S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32406", "l": "(1R,2S,4R)-neodihydrocarveol + NAD(+) <=> (1R,4R)-dihydrocarvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1370505", "l": "PRLR is phosphorylated at Ser-349 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63105", "l": "H(+) + ilicicolin A epoxide + NADPH + O2 => 16-hydroxy-ilicicolin A epoxide + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202713", "l": "CD84 homodimerises (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665989", "l": "DIAPH1 binds RHOA:GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1362485", "l": "GHBP binds GH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199203", "l": "PANK1/3/4 phosphorylate PanK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853792", "l": "RET tyrosine phosphorylation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32360", "l": "1D-myo-inositol 1,4,5-trisphosphate + 2 ATP => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9674095", "l": "PDGFRs bind type II TKI (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25454", "l": "diphosphate + germacrene A => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33509", "l": "(2E)-hexadecenal + phosphoethanolamine => sphing-4-enine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047435", "l": "5-guanidino-2-oxopentanoate decarboxylase activity"}, {"i": "MetaCyc:4.1.1.75-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57410", "l": "3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADH => (2R)-3-(3,4-dihydroxyphenyl)lactate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190258", "l": "FGFR2c binds to FGF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28422", "l": "(1E,2S)-2-methylbutanal oxime + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2-methylbutanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31146", "l": "(3S)-hydroxyhexanoyl-CoA + NAD(+) <=> 3-oxohexanoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-432010", "l": "Aquaporin-1 passively transports water into cell (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17206", "l": "3'-phosphoadenylyl sulfate + quercetin 3-sulfate => adenosine 3',5'-bisphosphate + H(+) + quercetin 3,4'-bissulfate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008936", "l": "nicotinamidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41230", "l": "(S)-4-hydroxymandelate + O2 <=> 4-hydroxyphenylglyoxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45965", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 H2O => 2 AMP + ATP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022880", "l": "protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13328", "l": "H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine <=> 3 H(+) + 2 NADH + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19275", "l": "N-acetylneuraminate + phosphate => H2O + N-acetyl-D-mannosamine + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220957", "l": "NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63331", "l": "2-(9Z-octadecenoyl)-glycerol + ATP <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40495", "l": "N-[omega-(9Z,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine + O2 = N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36897", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-CoA + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4090281", "l": "PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944218", "l": "Association of procollagen type VIII (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047010", "l": "hydroxycyclohexanecarboxylate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013109", "l": "RHOC GEFs activate RHOC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592387", "l": "Fibulin binds elastic fibres (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990444", "l": "F-box domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58754", "l": "1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45717", "l": "H2O + N,N,N-trimethylglycyl-CoA => CoA + glycine betaine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33891", "l": "chanoclavine-I + NAD(+) = chanoclavine-I aldehyde + H(+) + NADH"}, {"i": "EC:1.1.1.332", "l": "\"Chanoclavine-I dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37659", "l": "anthraniloyl-CoA + methanol = CoA + O-methyl anthranilate"}, {"i": "EC:2.3.1.232", "l": "\"Methanol O-anthraniloyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24343", "l": "(R,R)-butane-2,3-diol + NAD(+) <=> (R)-acetoin + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961678", "l": "ORC1 gene expression is stimulated by E2F1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39380", "l": "(2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H(+) + NADPH => (15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21344", "l": "5-hydroxybenzimidazolylcob(I)amide + H(+) + methanol = Co-methyl-Co-5-hydroxybenzimidazolylcob(III)amide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59848", "l": "(2R,3S)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH = (S)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15683", "l": "(2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + 2 H(+) + NADH => 2-hydroxy-5-carboxymethylmuconate semialdehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49477", "l": "2 H2O + L-1-piperideine-6-carboxylate + NAD(+) => H(+) + L-2-aminoadipate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16571", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate => 2-oxoglutarate + L-lysyl-[collagen] + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "68.3621111081913", "identifiers": [{"i": "GO:0016638", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors"}, {"i": "EC:1.4.-.-", "l": "\"Acting on the CH-NH(2) group of donors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981621", "l": "Neuroglobin:oxygen dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944236", "l": "Association of procollagen type XIV (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24460", "l": "H(+) + malonyl-[ACP] = acetyl-[ACP] + CO2"}, {"i": "EC:4.1.1.87", "l": "\"Malonyl-S-ACP decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18836", "l": "4-formylbenzenesulfonate + H2O + NAD(+) <=> 4-sulfobenzoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-606349", "l": "Mis18 complex binds the centromere (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53030", "l": "H(+) + lithocholoyl-3-O-(beta-D-glucuronate) + UDP => lithocholate + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10393", "l": "(E)-cinnamyl alcohol + NADP(+) => (E)-cinnamaldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15513", "l": "ATP + keto-D-tagatose = ADP + H(+) + keto-D-tagatose 6-phosphate"}, {"i": "EC:2.7.1.101", "l": "\"Tagatose kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852019", "l": "MET bound PI3K generates PIP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1963589", "l": "ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48302", "l": "glycerol + H(+) + prostaglandin F2alpha => H2O + prostaglandin F2alpha 1-glyceryl ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374919", "l": "Noradrenaline clearance from the synaptic cleft (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68603", "l": "ORC5 binds ORC2:ORC3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62755", "l": "H2O + pravastatin lactone <=> (S)-2-methylbutanoate + H(+) + pravastatin diol lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28848", "l": "Li(+)(in) + melibiose(in) => Li(+)(out) + melibiose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357483", "l": "RAC1 binds PAK1-3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35923", "l": "neamine + UDP-alpha-D-glucose = 3''-deamino-3''-hydroxykanamycin B + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35319", "l": "H(+) + malonyl-CoA + octadecanoyl-CoA = 3-oxoeicosanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62296", "l": "(+)-premalbrancheamide + 2 chloride + 2 FAD + 4 H(+) = (+)-malbrancheamide + 2 FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46039", "l": "2'-deoxycytidine + UTP <=> dCMP + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9627107", "l": "XIAP binds CASP7 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59585", "l": "ATP + beta-alanine + L-lysine => ADP + beta-alanyl-L-lysine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534365", "l": "Slo3 Potassium Transport (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190065", "l": "Activated TrkA receptor internalizes to endosomes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43668", "l": "ATP + hexacosanoyl-CoA + hydrogencarbonate = 2-carboxyhexacosanoyl-CoA + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22835", "l": "H2O + N-formimidoyl-L-glutamate <=> N-formyl-L-glutamate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103014", "l": "beta-keto ester reductase activity"}, {"i": "MetaCyc:RXN0-1941"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-912790", "l": "CBL binds CRK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35624", "l": "D-glutamate + D-glutamine => D-gamma-glutamyl-D-glutamate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35712", "l": "acetate + succinyl-CoA => acetyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31478", "l": "soyasapogenol B + UDP-alpha-D-glucuronate <=> H(+) + soyasapogenol B 3-O-beta-D-glucuronate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11980", "l": "2 L-gamma-glutamyl-L-cysteine + NADP(+) = bis-gamma-glutamylcystine + H(+) + NADPH"}, {"i": "EC:1.8.1.13", "l": "\"Bis-gamma-glutamylcystine reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37880", "l": "methyl aklanonate => aklaviketone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44149", "l": "L-lysine => D-beta-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16819", "l": "6-phospho-2-dehydro-D-gluconate + H(+) + NADPH => 6-phospho-D-gluconate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39193", "l": "docosanoyl-CoA + NADP(+) => (2E)-docosenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801109", "l": "CHM binds RGGT (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24991", "l": "(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin] <=> calcitroate + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432464", "l": "Phosphorylated TIM:PER heterodimer dissociate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22845", "l": "(6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] => glyceollin I + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-169719", "l": "Secreted CD14 binds LPS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20222", "l": "(6S)-5,6,7,8-tetrahydrofolate + ATP + formate => (6S)-10-formyltetrahydrofolate + ADP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.1", "l": "\"Ethanolaminephosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183052", "l": "CBL binds to GRB2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39458", "l": "(2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + NADPH <=> (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64035", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP-beta-L-fucose <=> a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23036", "l": "2 inosine + O2 = 2 5'-dehydroinosine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38296", "l": "(R)-2-hydroxyglutarate + A => 2-oxoglutarate + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691131", "l": "CANDI binds CUL1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60301", "l": "N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2395517", "l": "NADPH transfers electrons to FDXR (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14248", "l": "ATP + H2O <=> AMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6813740", "l": "GDE1 hydrolyzes GroPIns (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37102", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O <=> a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55480", "l": "ent-cassa-12,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = ent-3beta-hydroxycassa-12,15-dien-2-one + 3 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.69", "l": "\"Ent-cassadiene hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13080", "l": "an acyl phosphate + D-hexose <=> a carboxylate + D-hexose phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16508", "l": "chorismate <=> 4-hydroxybenzoate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114254", "l": "CYCS binds to APAF1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17540", "l": "(R)-carnitinamide + H2O <=> (R)-carnitine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34560", "l": "1-deoxy-11beta-hydroxypentalenate + NAD(+) => 1-deoxy-11-oxopentalenate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166220", "l": "FA anion diffuses laterally to UCP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20978", "l": "an aldehyde + H(+) + H2O2 + nitrite => a primary nitroalkane + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52248", "l": "6 H2O + 4 Mn(3+) + O2 = 12 H(+) + 4 MnO2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050462", "l": "N-acetylneuraminate synthase activity"}, {"i": "MetaCyc:N-ACETYLNEURAMINATE-SYNTHASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49380", "l": "5-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 5,20-dihydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16547", "l": "formate + oxalyl-CoA => formyl-CoA + oxalate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801641", "l": "TP53 binds the PLK2 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66412", "l": "ATP + glutathione(in) + H2O + taurochenodeoxycholate(in) = ADP + glutathione(out) + H(+) + phosphate + taurochenodeoxycholate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61890", "l": "diosgenin 3-O-beta-D-glucoside + H(+) + UDP => diosgenin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52228", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 = 3 A + biliverdin beta + CO + Fe(2+) + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60224", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + 2 succinate"}, {"i": "EC:1.14.11.68", "l": "\"[Histone H3]-trimethyl-L-lysine(27) demethylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030160", "l": "synaptic receptor adaptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043821", "l": "propionyl-CoA:succinate CoA-transferase activity"}, {"i": "RHEA:28010", "l": "propanoyl-CoA + succinate = propanoate + succinyl-CoA"}, {"i": "MetaCyc:RXN0-268"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28467", "l": "pyridoxamine(in) => pyridoxamine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57859", "l": "(E)-feruloyl-CoA + 2-oxoglutarate + O2 <=> (E)-6-hydroxyferuloyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41690", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + propanoate => 1-O-hexadecyl-2-propanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701199", "l": "Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23383", "l": "N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N,N'-diacetylchitobiosyl diphosphodolichol + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39209", "l": "(3R)-hydroxyhexacosanoyl-CoA + NADP(+) => 3-oxohexacosanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37231", "l": "H2O + L-alaninamide = L-alanine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11712", "l": "3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.2.7.7", "l": "\"3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15433", "l": "(2S)-naringenin + dimethylallyl diphosphate = diphosphate + sophoraflavanone B"}, {"i": "EC:2.5.1.70", "l": "\"Naringenin 8-dimethylallyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322434", "l": "XIAP dissociates from ub-TLE (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51385", "l": "hexadecanoyl-CoA + serotonin => CoA + H(+) + N-hexadecanoyl-serotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51930", "l": "(S)-2,3-diaminopropanoate + 2-oxoglutarate + H(+) + NADH => H2O + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26470", "l": "(E)-feruloyl-CoA + 16-hydroxyhexadecanoate = 16-feruloyloxyhexadecanoate + CoA"}, {"i": "EC:2.3.1.188", "l": "\"Omega-hydroxypalmitate O-feruloyl transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1369028", "l": "ABCAs mediate lipid efflux (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57971", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8-epi-inunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68615", "l": "Formation of ORC(1-6) complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031810", "l": "H4 histamine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44965", "l": "(2E)-dodecenoyl-CoA + H(+) + NADPH => dodecanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25656", "l": "(2S)-2-amino-3-oxobutanoate + H(+) <=> aminoacetone + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-171059", "l": "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21187", "l": "dolichyl phosphate + GDP-alpha-D-mannose <=> dolichyl beta-D-mannosyl phosphate + GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5625426", "l": "Retrograde IFT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21751", "l": "(S)-lactaldehyde + NADP(+) <=> H(+) + methylglyoxal + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168038", "l": "Collagen type XV restin release (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2900743", "l": "NOTCH1 HD+PEST domain mutants bind JAG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26026", "l": "8'-apo-beta-carotenol + O2 <=> (3E,5E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55920", "l": "[cis-1,4-isoprene](n) + O2 = (4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal + cis-1,4-isoprene(n-3)"}, {"i": "EC:1.13.11.85", "l": "\"Exo-cleaving rubber dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8979071", "l": "KDM6B binds iron (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928646", "l": "EPHAs bind EFNAs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64743", "l": "H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine <=> 3-methyl-3-sulfanylhexan-1-ol + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17561", "l": "acetylcholine + H2O = acetate + choline + H(+)"}, {"i": "EC:3.1.1.7", "l": "\"Acetylcholinesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033711", "l": "4-phosphoerythronate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446322", "l": "PARVA associates with Paxillin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852019", "l": "MET bound PI3K generates PIP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5685156", "l": "ATR phosphorylates RPA2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77081", "l": "Formation of the CE:GMP intermediate complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41130", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-dodecanoyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65475", "l": "2-methylbutanoyl-CoA + ethanol <=> CoA + ethyl 2-methylbutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27740", "l": "2-deoxy-alpha-D-ribose 1-phosphate + guanine => 2'-deoxyguanosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022453", "l": "MECP2 binds 5hmC-DNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102729", "l": "6-oxocampestanol hydroxylase activity"}, {"i": "MetaCyc:RXN-715"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176298", "l": "Activation of claspin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23834", "l": "ADP + an N-acyl-D-mannosamine 6-phosphate + H(+) => an N-acyl-D-mannosamine + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205117", "l": "p75NTR:NADE promotes caspase2/3 activation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13985", "l": "ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine"}, {"i": "EC:2.7.1.39", "l": "\"Homoserine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351208", "l": "Spermidine  => N-acetylated spermidine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9035227", "l": "TXN2 binds CysS248-MPST (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17704", "l": "ATP + geranoyl-CoA + hydrogencarbonate <=> 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113429", "l": "Elongating transcript encounters a lesion in the template (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0003779", "l": "actin binding"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004883", "l": "glucocorticoid receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672980", "l": "Dissociation of RAS:RAF complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59741", "l": "L-cysteinyl-[protein] + octadecanoyl-CoA => CoA + S-octadecanoyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44453", "l": "3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.14"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51892", "l": "H2O + N-acetylcadaverine = acetate + cadaverine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15342", "l": "ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide => ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42260", "l": "H(+) + heptanoyl-CoA + malonyl-[ACP] = 3-oxononanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047740", "l": "cephalosporin-C transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204798", "l": "Interaction of Tie2 and p85 of PI3K (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421833", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683593", "l": "ATG7:ATG3:LC3 dissociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74734", "l": "Re-integration of insulin receptor into plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41101", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429529", "l": "Thrombin binding to GP1b:IX:V (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30346", "l": "FAD + H(+) + succinate <=> FADH2 + fumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011543", "l": "DCA binds PDK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28505", "l": "NAD(+) + S-(hydroxymethyl)mycothiol <=> H(+) + NADH + S-formylmycothiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20715", "l": "6-carboxyhexanoyl-CoA + H(+) + L-alanine <=> (S)-8-amino-7-oxononanoate + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54720", "l": "N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18083", "l": "diphosphate + pentalenene => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47661", "l": "acetyl-CoA + L-methionine sulfoximine => CoA + H(+) + N-acetyl-L-methionine sulfoximine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052857", "l": "NADPHX epimerase activity"}, {"i": "RHEA:32227", "l": "(6R)-NADPHX = (6S)-NADPHX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75891", "l": "Abortive Initiation After Second Transition (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854981", "l": "SHC1 in the RET complex is phosphorylated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2214351", "l": "PLK1 phosphorylates GORASP1 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004677", "l": "DNA-dependent protein kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.3"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047874", "l": "dolichyldiphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54619", "l": "2-oxoglutarate + heptadecanoyl-CoA + O2 <=> 2-hydroxyheptadecanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65514", "l": "5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O2 => 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052858", "l": "peptidyl-lysine acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27807", "l": "acetoacetate + acetyl-CoA => acetate + acetoacetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39505", "l": "(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+) => (2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59620", "l": "H2O + N(2)-(4-aminobutanoyl)-L-lysine = 4-aminobutanoate + L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66231", "l": "asc-C13-CoA + O2 <=> asc-DeltaC13-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000386", "l": "second spliceosomal transesterification activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12088", "l": "an N-acylsphing-4-enine + UDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP"}, {"i": "EC:2.4.1.80", "l": "\"Ceramide glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210805", "l": "Removal of miRNA passenger strand (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097726", "l": "LEM domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61487", "l": "a cytidine in rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5591086", "l": "SERPINA5 binds activated protein C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983266", "l": "Kinesins bind microtubules (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047539", "l": "2-deoxyglucosidase activity"}, {"i": "MetaCyc:2-DEOXYGLUCOSIDASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443418", "l": "GP1b signaling involves c-Src (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114558", "l": "Thrombin-activated PARs activate Gq (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5632738", "l": "DDIT4 binds 14-3-3 dimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76456", "l": "O-atom dealkylation of dextromethorphan (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030774", "l": "anthranilate N-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49945", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate => (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17243", "l": "an alcohol + an alpha-amino acid + H(+) => an alpha-amino acid ester + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-392749", "l": "Transport of L1 into endosomes (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8934465", "l": "SHC1 binds PTPN12 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878117", "l": "RUNX3 binds ZFHX3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62171", "l": "H2O + N,N'-diacetylchitobiose <=> acetate + beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508513", "l": "PTK2B binds JAK3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50260", "l": "11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione = (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61644", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L-arginine = 2 [Fe(III)-cytochrome b5] + H2O + L-arginine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004107", "l": "chorismate synthase activity"}, {"i": "RHEA:21020", "l": "5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate"}, {"i": "EC:4.2.3.5", "l": "\"Chorismate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134954", "l": "DHX9 binds DNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59749", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] => CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2029468", "l": "Conversion of PA into DAG by PAP-1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68826", "l": "Free CDT1 associates with CDC6:ORC:origin complexes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43425", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.-.-.-", "l": "\"Oxidoreductases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40268", "l": "(3S)-hydroxyhexadecanedioyl-CoA + NAD(+) => 3-oxohexadecanedioyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28167", "l": "5-nitroanthranilate + H(+) + H2O => 5-nitrosalicylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050164", "l": "oxoglutarate dehydrogenase (NADP+) activity"}, {"i": "MetaCyc:OXOGLUTARATE-DEHYDROGENASE-NADP+-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35781", "l": "mutildienyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432897", "l": "ILK interacts with beta-1 integrin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41590", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+) => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417127", "l": "Elongation and translocation of the extended telomeric chromosome end (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37697", "l": "1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49632", "l": "(2E,6E)-farnesyl diphosphate + 3,5-dimethylorsellinate = (3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26218", "l": "abieta-7,13-diene + O2 + reduced [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769394", "l": "AKT phosphorylates CBY1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873927", "l": "Release of STAT1 dimer from active receptor unit (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051498", "l": "syn-copalyl diphosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38356", "l": "(R)-3-phenyllactoyl-CoA => (E)-cinnamoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54078", "l": "diphosphate + stellata-2,6,19-triene => (2E,6E,10E,14E)-geranylfarnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167085", "l": "Formation of DSIF:NELF:HIV-1 early elongation complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29252", "l": "2 H(+)(out) + Na(+)(in) => 2 H(+)(in) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013021", "l": "GDIs block activation of RHOB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39919", "l": "1-O-(alk-1-enyl)-sn-glycero-3-phosphate + H2O = 1-O-(alk-1-enyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42558", "l": "pseudouridine(2819) in 21S rRNA => uridine(2819) in 21S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22509", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) => diphosphate + DNA(n+1)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027280", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64949", "l": "dCTP + H2O => dCDP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036139", "l": "peptidyl-histidine dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13145", "l": "4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate = alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine"}, {"i": "EC:2.4.1.320", "l": "\"1,4-beta-mannosyl-N-acetylglucosamine phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060228", "l": "phosphatidylcholine-sterol O-acyltransferase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43900", "l": "dalpatein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O = beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalpatein + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11284", "l": "hydroxymalonate + NAD(+) = H(+) + NADH + oxomalonate"}, {"i": "EC:1.1.1.167", "l": "\"Hydroxymalonate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34552", "l": "ATP + cob(II)yrinate c monoamide + H2O + L-glutamine => ADP + cob(II)yrinate a,c diamide + H(+) + L-glutamate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624131", "l": "UNC119B binds myristoylated proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014293", "l": "RAC2 GDIs block activation of RAC2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112385", "l": "Addition of nucleotides leads to transcript elongation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-984606", "l": "Kinesin-5 is a homotetramer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004410", "l": "homocitrate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2129353", "l": "Tropoelastin associates with microfibrils (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49710", "l": "H(+) + isonocardicin C + S-methyl-5'-thioadenosine => nocardicin G + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34524", "l": "[alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose => [alpha-D-GalNAc-(1->4)]2-[beta-D-Glc-(1->3)]-[alpha-D-GalNAc-(1->4)]2-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019182", "l": "histamine-gated chloride channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749197", "l": "ORC1 binds to H4K20me2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.30", "l": "\"Flavin reductase (NADPH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-427570", "l": "Group 3 - Selective Cl- transport (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388468", "l": "AVP(20-28) binds AVPR1A,B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17182", "l": "a long-chain fatty aldehyde + FMNH2 + O2 => a long-chain fatty acid + FMN + 2 H(+) + H2O + hnu"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61983", "l": "H(+) + NADPH + ubiquinone-10 <=> NADP(+) + ubiquinol-10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209903", "l": "Noradrenaline is converted to adrenaline (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862184", "l": "USP48 cleaves polyubiquitin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11418", "l": "1,6-bis-O-galloyl-beta-D-glucose + D-glucose => 2 1-O-galloyl-beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33090", "l": "cyclic dehypoxanthinylfutalosinate <=> 1,4-dihydroxy-6-naphthoate + chemical entity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607724", "l": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683801", "l": "CHEK2 phosphorylates BRCA1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70592", "l": "PXLP-K259-GOT1 dimer deaminates L-Asp (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51318", "l": "H2O + N-(9Z-octadecenoyl)glycine => (9Z)-octadecenoate + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18154", "l": "2 GTP + H(+) => diphosphate + P(1),P(4)-bis(5'-guanosyl) tetraphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31484", "l": "soyasapogenol E + UDP-alpha-D-glucuronate => H(+) + soyasapogenol E 3-O-beta-D-glucuronate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296244", "l": "SUCNR1 binds SUCCA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66650", "l": "african-3-ene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37159", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710306", "l": "GSDME expression mediated by TP53, TP63 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26164", "l": "AH2 + echinenone + O2 = 4'-hydroxyechinenone + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018809", "l": "E-phenylitaconyl-CoA hydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047028", "l": "6-pyruvoyltetrahydropterin 2'-reductase activity"}, {"i": "MetaCyc:1.1.1.220-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53842", "l": "7,12-dioxo-lithocholate + H(+) + NADPH => 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28086", "l": "2 H2O2 + Reactive Blue 5 = 2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H(+) + 2 H2O + phthalate"}, {"i": "EC:1.11.1.19", "l": "\"Dye decolorizing peroxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20593", "l": "H2O + N-acetyl-D-glucosamine = acetate + D-glucosamine"}, {"i": "EC:3.5.1.33", "l": "\"N-acetylglucosamine deacetylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45060", "l": "H2O + N-(9Z-octadecenoyl) ethanolamine = (9Z)-octadecenoate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034908", "l": "2-chloro-N-isopropylacetanilide 1,2-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781905", "l": "ZRANB1 binds APC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28103", "l": "GDP-alpha-D-mannose + H2O => D-mannose + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.46", "l": "\"Adamalysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63073", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA => 4 CO2 + 4 CoA + orcinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2314686", "l": "Aspirin acetylates PTGS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27308", "l": "1-pyrroline-2-carboxylate + AH2 => A + D-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10960", "l": "(S)-lactate = (R)-lactate"}, {"i": "EC:5.1.2.1", "l": "\"Lactate racemase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40482", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63341", "l": "ATP + L-amino acyl-L-seryl-[protein] => (S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41891", "l": "3-oxotetradecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38216", "l": "D-glucose 6-phosphate + NAD(+) => 6-phospho-D-glucono-1,5-lactone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14459", "l": "3-propylmalate + CoA + H(+) => glyoxylate + H2O + pentanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851908", "l": "Activated MET binds GAB1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66220", "l": "asc-omegaC7-CoA + O2 = asc-omegaDeltaC7-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4837364", "l": "Secretion of SOD3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23819", "l": "2-oxoglutarate + putrescine <=> 4-aminobutanal + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42410", "l": "(2R)-2,3-bisphosphoglycerate + ADP + H(+) => (2R)-2-phosphoglycerate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443817", "l": "Phosphorylation of L1 by EPHB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24158", "l": "2-methylpropanoyl phosphate + ADP => 2-methylpropanoate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26415", "l": "a secondary aliphatic amine + H2O + O2 => a primary amine + an aldehyde + H2O2"}]}
{"type": "biolink:MolecularActivity", "ic": "77.349316285872916", "identifiers": [{"i": "GO:0004402", "l": "histone acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781840", "l": "ERCC6 binds stalled RNA Pol II (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876789", "l": "CARNMT1 methylates CARN to Anserine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-593685", "l": "Netrin-4 binds DCC/UNC5A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869683", "l": "oxPL binds LBP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390649", "l": "CHRM1,3,5 bind acetylcholine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46285", "l": "2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 => (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28035", "l": "[thioredoxin]-disulfide + dADP + H2O => [thioredoxin]-dithiol + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446634", "l": "IRAK4 is activated by autophosphorylation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451377", "l": "Interaction of IQGAP1 with nephrin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23028", "l": "malonyl-[ACP] + N(6)-biotinyl-L-lysyl-[protein] = acetyl-[ACP] + N(6)-carboxybiotinyl-L-lysyl-[protein]"}, {"i": "EC:2.1.3.10", "l": "\"Malonyl-S-ACP:biotin-protein carboxyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12731", "l": "(3R,3'S)-zeaxanthin => lutein"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050046", "l": "delta7-sterol 5(6)-desaturase activity"}, {"i": "MetaCyc:1.14.21.6-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12753", "l": "glycerol + NADP(+) = dihydroxyacetone + H(+) + NADPH"}, {"i": "EC:1.1.1.156", "l": "\"Glycerol 2-dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60190", "l": "2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3209165", "l": "ID1 sequesters ETS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27660", "l": "2-deoxy-D-ribose 5-phosphate => 2-deoxy-alpha-D-ribose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51262", "l": "(10bR,4aS)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56053", "l": "2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => 2 alpha-D-mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14119", "l": "[(1->4)-alpha-D-galacturonosyl](n-1) + alpha-D-galacturonate => [(1->4)-alpha-D-galacturonosyl](n) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10344", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA"}, {"i": "EC:2.3.1.25", "l": "\"Plasmalogen synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102970", "l": "7-deoxyloganetic acid glucosyltransferase activity"}, {"i": "RHEA:39895", "l": "7-deoxyloganetate + UDP-alpha-D-glucose = 7-deoxyloganate + H(+) + UDP"}, {"i": "EC:2.4.1.323", "l": "\"7-deoxyloganetic acid glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16708", "l": "17alpha-estradiol + NADP(+) <=> estrone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50603", "l": "acetyl-CoA + N-terminal L-seryl-[histone H2A] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19561", "l": "androst-4-ene-3,17-dione + H(+) + NADPH + O2 = H2O + NADP(+) + testololactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983374", "l": "p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788628", "l": "p-Y-STATs dissociate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20090", "l": "acetyl-CoA + L-leucine => CoA + H(+) + N-acetyl-L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11256", "l": "H2O + limonin + UDP-alpha-D-glucose = glucosyl-limonin + 2 H(+) + UDP"}, {"i": "EC:2.4.1.210", "l": "\"Limonoid glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22690", "l": "H2O2 + NH4(+) + pyruvate => D-alanine + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44233", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-481010", "l": "Surface deployment of platelet dense granule membrane components (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23770", "l": "an N-acylsphing-4-enine + CoA + H(+) => a fatty acyl-CoA + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340226", "l": "CYGB dioxygenates NO (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008726", "l": "alkanesulfonate monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45421", "l": "H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine => a fatty acid + H(+) + N-acyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013159", "l": "CDC42 GEFs activate CDC42 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66016", "l": "bromide + H2O2 = H2O + hypobromite"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0031685", "l": "adenosine receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59624", "l": "H2O + N(2)-(4-aminobutanoyl)-L-ornithine = 4-aminobutanoate + L-ornithine"}, {"i": "EC:3.4.13.4", "l": "\"Xaa-Arg dipeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31959", "l": "9beta-pimara-7,15-dien-19-ol + O2 + reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-dien-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50411", "l": "1-(2-aminophenyl)decane-1,3-dione <=> 2-heptyl-4(1H)-quinolone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.5.7", "l": "\"Cyclic alcohol dehydrogenase (quinone)\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103042", "l": "4-hydroxy-L-threonine aldolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29061", "l": "2 H(+)(out) + ubiquinol-8 => 2 H(+)(in) + H2 + ubiquinone-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25410", "l": "ADP + alpha,alpha-trehalose + H(+) => ADP-alpha-D-glucose + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51010", "l": "2 [Fe(II)cytochrome cL] + formaldehyde + 2 H(+) => 2 [Fe(III)cytochrome cL] + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694409", "l": "Nucleotide exchange on RAB1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865320", "l": "CBFB binds RUNX1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62210", "l": "3-hydroxybenzyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-methylphenol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28164", "l": "CMP + GDP + H(+) => cytidine + GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.315", "l": "\"11-cis-retinol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322431", "l": "XIAP binds TLE (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.18", "l": "\"ADP-dependent short-chain-acyl-CoA hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41535", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 <=> (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26264", "l": "H2O + isopimara-7,15-dienal + NADP(+) <=> 2 H(+) + isopimarate + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003786", "l": "actin lateral binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.74", "l": "\"Chalcone synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54991", "l": "4 e(-) + 4 H(+)(in) + O2(in) <=> 2 H2O(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53697", "l": "2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O => (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46273", "l": "2 [Fe(II)-cytochrome b5] + an N-acyl-(4R)-4-hydroxysphinganine + 2 H(+) + O2 => (4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8873929", "l": "Casein kinase II phosphorylates STARD10 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417898", "l": "P2Y4 receptor can bind to UTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34236", "l": "4-nitro-6-oxohepta-2,4-dienedioate => 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58577", "l": "dihydroprecondylocarpine acetate + NADP(+) => H(+) + NADPH + precondylocarpine acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37184", "l": "(9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate => 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14211", "l": "diphosphate + UDP-alpha-D-galactose => alpha-D-galactose 1-phosphate + H(+) + UTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3927886", "l": "SUMOylation of NCOR2 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682026", "l": "MRN bound to shortened telomeres activates ATM (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12218", "l": "9H-fluoren-9-one + H(+) + NADH => 9H-fluoren-9-ol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0035174", "l": "histone serine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2203479", "l": "STAB2 (FEEL-2) binds ligands (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50477", "l": "anthraniloyl-CoA + L-cysteinyl-[PqsD protein] => CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50339", "l": "O2 + reduced [NADPH--hemoprotein reductase] + triacontanoate <=> H(+) + H2O + omega-hydroxy-triacontanoate + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182594", "l": "Association of INK4 family proteins with CDK4/6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983147", "l": "Release of E3 from polyubiquitinated substrate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11231", "l": "(2S)-flavan-4-ol + NADP(+) <=> (2S)-flavanone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389848", "l": "TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58127", "l": "(19S)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + polyneuridine aldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51209", "l": "20-hydroxy-leukotriene B4 + NADP(+) => 12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55299", "l": "13-cis-retinol + hexadecanoyl-CoA <=> 13-cis-retinyl hexadecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52408", "l": "4-phospho-D-erythronate + NAD(+) = CO2 + dihydroxyacetone phosphate + NADH"}, {"i": "EC:1.1.1.409", "l": "\"4-phospho-D-erythronate 3-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44093", "l": "ATP + CoA + nonadecanoate => AMP + diphosphate + nonadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035731", "l": "dinitrosyl-iron complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865994", "l": "GAB1 binds PTPN11 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-688985", "l": "K63 polyubiquitinated RIP2 associates with the TAK1 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33032", "l": "D-fructose + H(+) + NADH => D-sorbitol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32324", "l": "ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47561", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) => CMP + ganglioside GM1b (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41863", "l": "(3R)-hydroxydecanoyl-[ACP] <=> (2E)-decenoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102430", "l": "alpha-linolenate delta5 desaturase activity"}, {"i": "RHEA:38039", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 H2O"}, {"i": "MetaCyc:RXN-13857"}, {"i": "EC:1.14.19.12", "l": "\"Acyl-lipid omega-(9-4) desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21242", "l": "diphosphate + S-geranylgeranyl-L-cysteinyl-[protein] => geranylgeranyl diphosphate + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788622", "l": "p-Y-STATs dimerize (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168376", "l": "STIM1 oligomerizes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-182990", "l": "Sprouty sequesters CBL away from active EGFR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008463", "l": "formylmethionine deformylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799332", "l": "ATR phosphorylates TP53 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55954", "l": "a mannosylinositol-1-phospho-N-acyl-sphingoid base + GDP + H(+) => an inositol-1-phosphoceramide + GDP-alpha-D-mannose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426223", "l": "Cation influx mediated by TRPC3/6/7 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14463", "l": "(25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP => (25S)-5beta-spirostan-3beta-ol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0003727", "l": "single-stranded RNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31404", "l": "all-trans-4,4'-diapo-zeta-carotene + FAD + H(+) => all-trans-4,4'-diaponeurosporene + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47497", "l": "lithocholate + NADP(+) => 3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019002", "l": "GMP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9678854", "l": "S1PR1 binds S1PR1 agonists (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59484", "l": "2 [Fe(III)cytochrome c] + arsenite + H2O = 2 [Fe(II)cytochrome c] + arsenate + 3 H(+)"}, {"i": "EC:1.20.2.1", "l": "\"Arsenate reductase (cytochrome c)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59469", "l": "an S-substituted glutathione + H2O => an S-substituted L-cysteinylglycine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36379", "l": "4alpha-methyl-5alpha-cholesta-8,24-dien-3-one + H(+) + NADPH = 4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424485", "l": "Release of p-PLCG1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8957389", "l": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55140", "l": "D-alanyl-5'-AMP + holo-[D-alanyl-carrier protein] = AMP + D-alanyl-[D-alanyl-carrier protein] + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42492", "l": "3'-N-debenzoyl-2'-deoxytaxol + AH2 + O2 = 3'-N-debenzoyltaxol + A + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050233", "l": "pyranose oxidase activity"}, {"i": "RHEA:10552", "l": "D-glucose + O2 = 2-dehydro-D-glucose + H2O2"}, {"i": "EC:1.1.3.10", "l": "\"Pyranose oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8854303", "l": "TBC1D11 binds RAB6 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990107", "l": "thiazole synthase activity"}, {"i": "RHEA:26297", "l": "1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O"}, {"i": "EC:2.8.1.10", "l": "\"Thiazole synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61889", "l": "diosgenin + UDP-alpha-D-glucose => diosgenin 3-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37840", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2129362", "l": "Fibrillin microfibril assembly (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43419", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210694", "l": "Phosphorylated STAT92E dimer is dephosphorylated by PTP61F isoform 2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34493", "l": "2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H(+) + UDP => H2O + UDP-N,N'-diacetylbacillosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202466", "l": "Interaction of Bcl10 to CARMA1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66077", "l": "2-oxopentanoate + L-kynurenine => H2O + kynurenate + L-2-aminopentanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2130706", "l": "MHC class II antigen processing (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62733", "l": "(+)-isomalbrancheamide B + bromide + FAD + 2 H(+) => (+)-isomalbrancheamide D + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48580", "l": "[pyruvate, water dikinase]-phosphate + H(+) + phosphate = [pyruvate, water dikinase] + diphosphate"}, {"i": "EC:2.7.4.28", "l": "\"([Pyruvate, water dikinase] phosphate) phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1638845", "l": "CERK phosphorylates CERA to form C1P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350385", "l": "DSH binds to RAC1:GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198669", "l": "p38MAPK phosphorylates MSK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25625", "l": "H2O + histamine + O2 = H2O2 + imidazole-4-acetaldehyde + NH4(+)"}, {"i": "EC:1.4.3.22", "l": "\"Diamine oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63082", "l": "A + AMP + diphosphate + ilicicolin B => AH2 + ATP + ilicicolinate B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12988", "l": "GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54721", "l": "N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43270", "l": "ganglioside GM2 + H(+) + UDP => ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37106", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O <=> (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40752", "l": "(9Z)-octadecenoate + 1-hexadecanoylglycerone 3-phosphate => 1-(9Z)-octadecenoylglycerone 3-phosphate + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54375", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-(2S,3R,9R)-pristinol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63629", "l": "ATP + hexadecanoate + holo-[ACP] => AMP + diphosphate + hexadecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433672", "l": "NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11088", "l": "H2O + trimetaphosphate = 2 H(+) + triphosphate"}, {"i": "EC:3.6.1.2", "l": "\"Trimetaphosphatase\""}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0005272", "l": "sodium channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15794", "l": "bilirubin IXalpha + NADP(+) => biliverdin IXalpha + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419861", "l": "Melanospin is stimulated by light (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3858482", "l": "DVL is recruited to the receptor (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418858", "l": "RhoGTPase GEF's recruited to DCC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30936", "l": "H2O + nicotinate beta-D-ribonucleotide => beta-D-ribosylnicotinate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62785", "l": "2 fonsecin B + H(+) + NADPH + O2 => bifonsecin B + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909718", "l": "Formation of p-STAT1 homodimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696358", "l": "TREM,CD300 binds lipids (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706330", "l": "Active FLT3 binds to SOCS6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11545", "l": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine => H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158832", "l": "The acetyl group from acetyl-CoA is transferred to the NAT2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11250", "l": "(R)-3-hydroxybutanoate + [(3R)-hydroxybutanoate](n-1) + H(+) => [(3R)-hydroxybutanoate](n) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21536", "l": "(3S)-hydroxy-3-methylglutaryl-CoA = H2O + trans-3-methylglutaconyl-CoA"}, {"i": "EC:4.2.1.18", "l": "\"Methylglutaconyl-CoA hydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806412", "l": "TP53 and AP-1 bind the MSH2 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202960", "l": "Caspase mediated cleavage of C-IAP1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57536", "l": "a ribonucleoside 5'-triphosphate + adenosine-5'-diphospho-5'-ribonucleotide-RNA = 5'-NTP-ribonucleotide-RNA + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.25"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21718", "l": "(6R)-L-erythro-6,7-dihydrobiopterin + (S)-4-hydroxymandelate + H2O => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + (S)-mandelate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52910", "l": "3-dimethylallyl-4-hydroxymandelate + CO2 => 3-dimethylallyl-4-hydroxyphenylpyruvate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43078", "l": "H(+) + 2 H2O + oleanolic aldehyde + oxidized [NADPH--hemoprotein reductase] => erythrodiol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44820", "l": "1,4-dihydroxy-2-naphthoate + all-trans-tridecaprenyl diphosphate + H(+) = 2-demethylmenaquinol-13 + CO2 + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990311", "l": "type-I cohesin domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.24", "l": "\"Quinate/shikimate dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64787", "l": "S-ethyl-L-cysteine <=> 2-aminoprop-2-enoate + ethanethiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29151", "l": "3 a ubiquinol(in) + 2 H(+)(out) + nitrite(out) = 3 a ubiquinone(in) + 2 H2O(out) + NH4(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41941", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate => [amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.10", "l": "\"Bacterial leucyl aminopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63238", "l": "6-O-adenylylstreptomycin + diphosphate => ATP + streptomycin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37316", "l": "glycyl-L-glutamine + H2O => glycine + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51542", "l": "(S)-corytuberine + 2 H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021068", "l": "PalmS-ESRs bind CAVs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45127", "l": "acarbose + ATP <=> acarbose 7(IV)-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76031", "l": "2 H2O2 => O2 + 2 H2O (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33176", "l": "4-hydroxyphenylacetate(in) => 4-hydroxyphenylacetate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40270", "l": "(3S)-hydroxyhexadecanedioyl-CoA + NAD(+) <=> 3-oxohexadecanedioyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928646", "l": "EPHAs bind EFNAs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013006", "l": "RHOA:GTP translocates to the ER membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65008", "l": "ATP + decanoate + H(+) = decanoyl-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3296309", "l": "HCAR3 binds HCAR3 ligands (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29842", "l": "L-idonate + NADP(+) <=> 2-dehydro-L-idonate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450488", "l": "BRF1 Complex recruits RNA degradation activities (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20190", "l": "5,6-dihydrouracil + NAD(+) => H(+) + NADH + uracil"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55100", "l": "3-oxopentanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxypentanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51647", "l": "cholesterol + H(+) + NADH + O2 <=> cholesta-5,7-dien-3beta-ol + 2 H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010280", "l": "UDP-L-rhamnose synthase activity"}, {"i": "MetaCyc:RXN-5482"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013145", "l": "RAC1 binds effectors at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696457", "l": "BDH2 dehydrogenates 3HBA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30069", "l": "glycine betaine + 2 H(+) + NADPH => betaine aldehyde + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102969", "l": "10-oxogeraniol oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374686", "l": "L1 interaction with Integrins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23635", "l": "D-threo-isocitrate + NAD(+) <=> 2-oxoglutarate + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52289", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33478", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15555", "l": "1D-myo-inositol 4-phosphate + phosphate => 1D-myo-inositol 1,4-bisphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25280", "l": "3',5'-cyclic AMP + H2O <=> AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45719", "l": "H2O + N,N,N-trimethylglycyl-CoA <=> CoA + glycine betaine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19983", "l": "H(+) + NADPH + S-formylglutathione => NADP(+) + S-(hydroxymethyl)glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52772", "l": "7,8-dihydroneopterin 3'-triphosphate = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde triphosphate"}, {"i": "EC:4.1.2.60", "l": "\"Dihydroneopterin triphosphate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033520", "l": "TYSND1 cleaves TYSND1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618107", "l": "ATP binding to HSP90 triggers conformation change (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21293", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390425", "l": "FAR1 reduces PalmCoA to HXOL (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000906", "l": "6,7-dimethyl-8-ribityllumazine synthase activity"}, {"i": "MetaCyc:LUMAZINESYN-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47338", "l": "16beta,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21368", "l": "H2O + O2 + urate = 5-hydroxyisourate + H2O2"}, {"i": "EC:1.7.3.3", "l": "\"Factor independent urate hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23767", "l": "diphosphate + L-serine <=> H(+) + O-phospho-L-serine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607724", "l": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641147", "l": "DACT1 binds DVL2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034722", "l": "gamma-glutamyl-peptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46341", "l": "ATP + N-hexadecanoylsphing-4-enine => ADP + H(+) + N-(hexadecanoyl)-sphing-4-enine-1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-164832", "l": "ATPase synthesizes ATP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66352", "l": "(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + NAD(+) = (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38707", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39436", "l": "(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-893609", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenic acid + H2O [cytosolic] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.42"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5604929", "l": "Activated protein C binds Protein S (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28665", "l": "alpha-D-galactose + beta-D-glucose => H2O + melibiose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46204", "l": "androst-5-en-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] = androst-5-en-3beta,7alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702601", "l": "midostaurin-resistant FLT3 mutants don't bind midostaurin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944232", "l": "Association of procollagen type XII (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798749", "l": "Exocytosis of specific granule lumen proteins (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27721", "l": "H2O + IMP <=> inosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50959", "l": "cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine <=> H(+) + N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56698", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate => D-ribulose 5-phosphate + L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20157", "l": "2n [Fe(III)cytochrome c] + a polyvinyl alcohol = 2n [Fe(II)cytochrome c] + an oxidized polyvinyl alcohol + 2n H(+)"}, {"i": "EC:1.1.2.6", "l": "\"Polyvinyl alcohol dehydrogenase (cytochrome)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54291", "l": "ATP + L-tyrosyl-[protein] <=> diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2995330", "l": "COX10 transforms heme to heme O (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12475", "l": "H2O + N-ethylglycine + O2 <=> ethylamine + glyoxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174124", "l": "Dephosphorylation of phospho-Cdh1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050262", "l": "ribosylnicotinamide kinase activity"}, {"i": "RHEA:14017", "l": "ATP + beta-nicotinamide D-riboside = ADP + beta-nicotinamide D-ribonucleotide + H(+)"}, {"i": "EC:2.7.1.22", "l": "\"Ribosylnicotinamide kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35807", "l": "2-dehydro-3-deoxy-D-arabinonate = 2,5-dioxopentanoate + H2O"}, {"i": "EC:4.2.1.141", "l": "\"2-dehydro-3-deoxy-D-arabinonate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56066", "l": "3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP => 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73932", "l": "Resynthesis of excised residue by POLB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-9635480", "l": "FadD26, FadD28 transfer adenylyl group to a LCFA (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62003", "l": "3 A + protoporphyrinogen IX <=> 3 AH2 + protoporphyrin IX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42081", "l": "all-trans-retinal + H2O + NAD(+) => all-trans-retinoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58740", "l": "H2O + psi-UTP = diphosphate + H(+) + psi-UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975106", "l": "Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203979", "l": "Coat Assembly (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218806", "l": "FYN autophosphorylates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935785", "l": "RUNX1 mRNA translation is inhibited by miR-17, miR-18a, miR-20a, miR-27a, miR-106a, miR-215, miR-302b, miR-378 and miR-675 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33751", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate"}, {"i": "EC:3.1.3.27", "l": "\"Phosphatidylglycerophosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982765", "l": "Growth hormone forms dimers and oligomers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192912", "l": "NP binds vRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5651773", "l": "LIG1 binds POLB at long-patch BER site (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56139", "l": "2 a phenolic donor + H2O2 <=> 2 a phenolic radical donor + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60444", "l": "an S-substituted L-cysteinylglycine + H2O = an S-substituted L-cysteine + glycine"}, {"i": "EC:3.4.13.23", "l": "\"Cysteinylglycine-S-conjugate dipeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45121", "l": "(4R)-ipsdienol + NAD(+) => H(+) + ipsdienone + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23102", "l": "ADP + dADP => ATP + dAMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-981809", "l": "ST6GALNAC3/4 can add a sialic acid to the sialyl T antigen to form the disialyl T antigen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448708", "l": "IL24 binds to IL22RA1:JAK1:IL20RB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12555", "l": "(E)-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> (E)-pinosylvin + 4 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19552", "l": "H2O + orsellinate depside <=> H(+) + 2 orsellinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000112", "l": "Endosomal TCII:Cbl translocates to lysosome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190168", "l": "HMBL spontaneously transforms to URO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32347", "l": "2 S-adenosyl-L-methionine + tricetin = 3',5'-di-O-methyltricetin + 2 H(+) + 2 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.175", "l": "\"Tricin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64359", "l": "2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 <=> (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H(+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48674", "l": "20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 20-oxo-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51777", "l": "4-prenylphlorisobutanophenone + dimethylallyl diphosphate => deoxycohumulone + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53343", "l": "5,6-dihydrouridine(20) in tRNA + NAD(+) <=> H(+) + NADH + uridine(20) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49133", "l": "an adenosine in tRNA + S-adenosyl-L-methionine => an N(1)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70971", "l": "citrate <=> isocitrate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000112", "l": "Endosomal TCII:Cbl translocates to lysosome (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47517", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => isochenodeoxycholate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14357", "l": "ATP + riboflavin = ADP + FMN + H(+)"}, {"i": "EC:2.7.1.26", "l": "\"Riboflavin kinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019186", "l": "acyl-CoA N-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15476", "l": "flavanone 7-O-beta-D-glucoside + UDP-beta-L-rhamnose <=> flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57279", "l": "a 2'-deoxyguanosine in DNA + glyoxal <=> an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1236970", "l": "Proteasomal clevage of exogenous antigen (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14205", "l": "carnosine + S-adenosyl-L-methionine = anserine + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.22", "l": "\"Carnosine N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38318", "l": "chorismate <=> 3-hydroxybenzoate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57430", "l": "formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] + phenol => anisole + O2 + reduced [NADH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48506", "l": "D-glycero-D-manno-heptose 1-phosphate + phosphate => D-glycero-D-manno-heptose 1,7-bisphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698179", "l": "FLT3 mutants recruit PIK3R1 through phosphorylated GAB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28702", "l": "Mn(2+)(in) <=> Mn(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44399", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1-heptadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21992", "l": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]"}, {"i": "RHEA:45948", "l": "acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]"}, {"i": "EC:2.3.1.48", "l": "\"Histone acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31004", "l": "(S)-2,3-epoxysqualene => germanicol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53381", "l": "5,6-dihydrouridine(16) in tRNA + NAD(+) => H(+) + NADH + uridine(16) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43625", "l": "2-aminomalonate semialdehyde + H(+) => aminoacetaldehyde + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.1", "l": "\"Alcohol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29483", "l": "(2E,6E)-farnesyl diphosphate = (+)-beta-selinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912412", "l": "NOTCH1 mRNA translation controlled by miRNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17811", "l": "Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine => Mg-protoporphyrin IX + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64022", "l": "GDP + H(+) + O-phospho-L-seryl-[protein] => GTP + L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40375", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58487", "l": "H2O + N-(acetyl)-sphing-4-enine <=> acetate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75079", "l": "Formation of AT-AC C complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000830", "l": "inositol hexakisphosphate 4-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809254", "l": "MTMR8 binds MTMR9 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56844", "l": "nocamycin E + S-adenosyl-L-methionine = nocamycin I + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.351", "l": "\"Nocamycin O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.16"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66769", "l": "ATP + coproporphyrin I(in) + H2O => ADP + coproporphyrin I(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60266", "l": "H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42224", "l": "A + testosterone = AH2 + androst-4-ene-3,17-dione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2032775", "l": "YAP1 binds TEAD1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9669854", "l": "KIT binds type II TKIs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14574", "l": "D-glucarate => 5-dehydro-4-deoxy-D-glucarate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080047", "l": "GDP-L-galactose phosphorylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60670", "l": "(1R,3R)-chrysanthemal + H(+) + NADH => (R,R)-chrysanthemol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54032", "l": "(6S)-10-formyltetrahydrofolate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose = (6S)-5,6,7,8-tetrahydrofolate + dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697008", "l": "CREBBP acetylates histone H2B, H3, H4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24846", "l": "2 isomaltose => cyclobis-(1->3)-alpha-isomaltosyl + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050512", "l": "lactosylceramide 4-alpha-galactosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15114", "l": "5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O => 5alpha-cholestane-3beta,5,6beta-triol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27577", "l": "(3R)-piperidine-3-carboxamide + H2O <=> (3R)-piperidine-3-carboxylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25142", "l": "(2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) <=> 3-amino-2-oxopropyl phosphate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445700", "l": "Myosin Binds ATP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694427", "l": "MIA3 binds procollagen VII (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031626", "l": "beta-endorphin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61301", "l": "5-deoxy-D-ribulose 1-phosphate => acetaldehyde + dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20404", "l": "a beta-lactam + H2O <=> a substituted beta-amino acid"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086059", "l": "voltage-gated calcium channel activity involved SA node cell action potential"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687097", "l": "p-S857 NCOA3 binds ETV4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16189", "l": "3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate"}, {"i": "EC:1.13.11.27", "l": "\"4-hydroxyphenylpyruvate dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47907", "l": "ATP + N-(acetyl)-sphing-4-enine <=> ADP + H(+) + N-(acetyl)-sphing-4-enine-1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655193", "l": "KIAA0101 double monoubiquitination (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25222", "l": "H(+) + L-cysteate => CO2 + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45431", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine <=> H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018837", "l": "2-hydroxy-2H-benzo[h]chromene-2-carboxylate isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24253", "l": "H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate => 2 ADP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41245", "l": "N-acyl-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoate (4E)-octadecasphin-4-enine => N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49621", "l": "D-erythritol 1-phosphate + NADP(+) => D-erythrulose 1-phosphate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56544", "l": "H2O + N-hexadecanoyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061929", "l": "gamma-glutamylaminecyclotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879319", "l": "glucosaminyl-inositol and cysteine are ligated to desacetylmycothiol (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53223", "l": "16alpha,17alpha-dihydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta,16alpha,17alpha-trihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38684", "l": "ATP + H2O + sphing-4-enine(in) => ADP + H(+) + phosphate + sphing-4-enine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.1.2.-", "l": "\"Hydron translocation linked to the hydrolysis of a nucleoside triphosphate\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76466", "l": "CYP4A11 12-hydroxylates DDCX (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49069", "l": "25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (1S)-1,25-dihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247922", "l": "GGCT transforms gGluCys to OPRO (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50561", "l": "acetyl-CoA + N-terminal L-methionyl-L-tryptophyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62078", "l": "6-phospho-D-galactono-1,5-lactone + H(+) + NADH => D-galactose 6-phosphate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72671", "l": "eIF5B:GTP is hydrolyzed and released (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9668395", "l": "CHMP7 binds CC2D1B (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10253", "l": "H(+) + hydrogen sulfide + O-phospho-L-serine => L-cysteine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044683", "l": "methylthiol:coenzyme M methyltransferase activity"}, {"i": "RHEA:32667", "l": "coenzyme M + methanethiol = H(+) + hydrogen sulfide + methyl-coenzyme M"}, {"i": "EC:2.1.1.251", "l": "\"Methylated-thiol--coenzyme M methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.46", "l": "\"L-arabinose 1-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693347", "l": "HTR1A binds 5HT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005006", "l": "epidermal growth factor-activated receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27640", "l": "alpha-D-ribose 1-phosphate + xanthine => phosphate + xanthosine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052680", "l": "epi-isozizaene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176956", "l": "Formation of GINS complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38445", "l": "a wax ester + CoA => a long chain fatty alcohol + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195734", "l": "Neuraminidase (NA) synthesis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395340", "l": "Formation of hydroxyallysine by LOX (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700120", "l": "PTN and MDK bind to PTPRZ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674529", "l": "AAMP binds to TBXA2R (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.99.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4837364", "l": "Secretion of SOD3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47863", "l": "ganglioside GT1b (d18:1(4E)) + H2O <=> ganglioside GD1b (d18:1(4E)) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66428", "l": "D-arabinose(out) + H(+)(out) = D-arabinose(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22138", "l": "chlorophyllide b + 2 H2O + NADP(+) => 7(1)-hydroxychlorophyllide a + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42301", "l": "a fatty acyl-[ACP] + sn-glycerol 3-phosphate => a 1-acyl-sn-glycero-3-phosphate + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948136", "l": "ULK1 Translocates to the mitochondria (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59102", "l": "H(+) + triglucosyl-enterobactin + UDP => diglucosyl-enterobactin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18953", "l": "L-erythro-7,8-dihydrobiopterin + NADP(+) = H(+) + NADPH + sepiapterin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674140", "l": "PAQR3 binds inactive RAFs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63532", "l": "angiotensin I + H2O = angiotensin-(1-9) + L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088306", "l": "FOXM1 binds PLK1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2002460", "l": "P4HB binds Collagen chains (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14541", "l": "choloyl-CoA + H2O = cholate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12726", "l": "D-iditol + NAD(+) => H(+) + keto-D-sorbose + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65025", "l": "7alpha-hydroxy-3,12-dioxo-5beta-cholanate + NADP(+) => dehydrocholate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.74"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41263", "l": "NAD(+) + prostaglandin A1 = 15-keto-prostaglandin A1 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-984606", "l": "Kinesin-5 is a homotetramer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036133", "l": "11-hydroxythromboxane B2 dehydrogenase activity"}, {"i": "KEGG.REACTION:R05060"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033917", "l": "exo-poly-alpha-galacturonosidase activity"}, {"i": "MetaCyc:3.2.1.82-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9679045", "l": "C-ter TLR9 dimer binds HCQ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45202", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + [Co(I) corrinoid Fe-S protein] + H(+) => (6S)-5,6,7,8-tetrahydrofolate + [methyl-Co(III) corrinoid Fe-S protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33084", "l": "dehypoxanthine futalosine + S-adenosyl-L-methionine => 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51238", "l": "GDP + H(+) + oxidized coenzyme F420-(gamma-Glu)(n+1) + phosphate => GTP + L-glutamate + oxidized coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26304", "l": "5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) <=> (S)-allantoin + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17840", "l": "2-carboxy-D-arabinitol 1-phosphate + H2O <=> 2-carboxy-D-arabinitol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8873794", "l": "PCTP binds PC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18989", "l": "H(+) + L-valine = 2-methylpropan-1-amine + CO2"}, {"i": "EC:4.1.1.14", "l": "\"Valine decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009676", "l": "low-affinity sulfate:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47828", "l": "ganglioside GT1b + H2O = ganglioside GD1b + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44062", "l": "2-O-sulfo-2'-O-hexadecanoyl-alpha,alpha-trehalose + CoA => 2-O-sulfo-alpha,alpha-trehalose + hexadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57984", "l": "(20S)-ginsenoside Rg3 + UDP-alpha-D-glucose = (20S)-ginsenoside Rd + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042903", "l": "tubulin deacetylase activity"}, {"i": "REACT:R-HSA-5618331", "l": "HDAC6 deacetylates microtubules (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047419", "l": "N-acetylgalactosamine-6-phosphate deacetylase activity"}, {"i": "MetaCyc:3.5.1.80-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62630", "l": "an alcohol + H2O + NAD(+) => a hydroperoxide + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58469", "l": "2 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 O2 => 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785165", "l": "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948582", "l": "miR-17 microRNA binds VAPA mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58844", "l": "(6E)-8-hydroxygeranial + NAD(+) = (6E)-8-oxogeranial + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203611", "l": "N-myristoylation of eNOS (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2889070", "l": "SLC9B2 exchanges Na+, Li+ for H+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38369", "l": "18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA => 8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37423", "l": "aclacinomycin N + O2 = aclacinomycin A + H2O2"}, {"i": "EC:1.1.3.45", "l": "\"Aclacinomycin-N oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21573", "l": "3-hydroxy-2-methyl-1H-quinolin-4-one + O2 => CO + H(+) + N-acetylanthranilate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52009", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102189", "l": "4alpha-hydroxymethyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity"}, {"i": "MetaCyc:RXN-11957"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20360", "l": "3-phenylpropanoate + H(+) + NADH + O2 <=> 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014467", "l": "RHOG binds effectors at the ER membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59532", "l": "(S)-reticuline + S-adenosyl-L-methionine = (S)-codamine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1467269", "l": "Beta-defensins bind microbial membranes causing disruption (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60688", "l": "(11R)-dihydroartemisinic aldehyde + H2O + NAD(+) = (11R)-dihydroartemisinate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.55", "l": "\"Non-reducing end alpha-L-arabinofuranosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10414", "l": "AMP + D-ribose 5-phosphate + 2 H(+) => ADP-D-ribose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23640", "l": "1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 = CO2 + ethene + 2 H2O + hydrogen cyanide + L-dehydroascorbate"}, {"i": "EC:1.14.17.4", "l": "\"Aminocyclopropanecarboxylate oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24333", "l": "3alpha-hydroxy-3,5-dihydromonacolin L carboxylate => H2O + monacolin L carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46541", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610735", "l": "NUMB binds ITCH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16344", "l": "(R)-5-phosphomevalonate + ATP <=> (R)-5-diphosphomevalonate + ADP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16919", "l": "2,3,6-trihydroxypyridine + H2O + NAD(+) => 2,6-dihydroxypyridine + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1248677", "l": "Inactivation of over-expressed wild type EGFR by Cetuximab recombinant antibody (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932070", "l": "ESR1 binds the AXIN1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55487", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-cassa-12,15-dien-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26539", "l": "hydrogencarbonate + NH4(+) + phosphate => carbamoyl phosphate + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3782655", "l": "HDAC10 deacetylates histone (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48470", "l": "ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate => ganglioside GM1b (d18:1(4E)) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38118", "l": "(9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol <=> 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50230", "l": "benzene-1,2,4-triol + FAD + H(+) + H2O => FADH2 + O2 + resorcinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41627", "l": "3-sulfinopropanoyl-CoA + H2O <=> H(+) + propanoyl-CoA + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10813", "l": "H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) => 2 H(+) + N-succinyl-L-glutamate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610954", "l": "HCMV Final Envelopment (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59804", "l": "L-phenylalanine = D-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64913", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O => a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847968", "l": "PTEN binds FRK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005477", "l": "pyruvate secondary active transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0048030", "l": "disaccharide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3134953", "l": "DHX36 or DHX9 binds MyD88 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801666", "l": "PLK2 phosphorylates CENPJ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50877", "l": "a hydroperoxy polyunsaturated fatty acid + H(+) + NADPH => a hydroxy polyunsaturated fatty acid + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-430311", "l": "Rsu-1 interacts with Pinch1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682626", "l": "nsp13 binds nsp12 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25392", "l": "(3Z)-6-oxohex-3-enoyl-CoA + H2O + NADP(+) => cis-3,4-dehydroadipyl-CoA + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980047", "l": "NOTCH1 stimulates HES1 transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23420", "l": "alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate"}, {"i": "EC:3.1.3.12", "l": "\"Trehalose-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46379", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63584", "l": "2-deoxyecdysone 22-phosphate + H2O = 2-deoxyecdysone + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35183", "l": "5-hydroxythiophene-2-carbonyl-CoA + H2O = 4-carboxy-2-thioxobutanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804383", "l": "PRMT5 methylates TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807144", "l": "HTN1,HTN3 or HTN5 binds the bacterial anionic surface  (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38159", "l": "(2S,3S)-hydroxyarginine = (2S,3R)-capreomycidine + H2O"}, {"i": "EC:4.2.1.145", "l": "\"Capreomycidine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22649", "l": "holo-[cytochrome c] => apo-[cytochrome c] + heme b"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65871", "l": "Delta(1)-dihydrotestosterone + H2O <=> 1,17beta-dihydroxyandrostan-3-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47998", "l": "H2O2 + NAD(+) => 1,6-dihydro-beta-NAD + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11412", "l": "6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)"}, {"i": "EC:2.7.6.3", "l": "\"2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34451", "l": "dTDP-6-deoxy-beta-L-talose = dTDP-beta-L-rhamnose"}, {"i": "EC:5.1.3.25", "l": "\"dTDP-L-rhamnose 4-epimerase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60272", "l": "N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036467", "l": "5-hydroxy-L-tryptophan decarboxylase activity"}, {"i": "RHEA:18533", "l": "5-hydroxy-L-tryptophan + H(+) = CO2 + serotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.30", "l": "\"Coccolysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42197", "l": "(9Z)-heptadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-heptadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41028", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + tetradecanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-tetradecanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465940", "l": "atRAL is reduced to atROL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57021", "l": "apulose + ATP => ADP + apulose 4-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63464", "l": "(2E,6E,10E)-geranylgeraniol + UTP = (2E,6E,10E)-geranylgeranyl phosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877414", "l": "FOXP3 in complex with RUNX1 binds the CTLA4 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218821", "l": "PDK1 phosphorylates PKC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26051", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] = glyceollin III + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.135", "l": "\"Glyceollin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417842", "l": "P2Y10 receptor can bind to LPA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250264", "l": "TXNIP binds reduced thioredoxin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0016530", "l": "metallochaperone activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19171", "l": "NH4(+) + pyruvate => L-serine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035797", "l": "tellurite methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25948", "l": "a 1,2-diacyl-sn-glycerol + CTP = a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H(+)"}, {"i": "EC:2.7.1.174", "l": "\"Diacylglycerol kinase (CTP)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21609", "l": "isoliquiritigenin + S-adenosyl-L-methionine => 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33721", "l": "a 1,2-diacyl-sn-glycerol + N-(hexacosanoyl)-sphinganine-1-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-hexacosanoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787820", "l": "IL34 dimer binds CSF1R (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672961", "l": "PP2A dephosphorylates inactive RAFs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654409", "l": "Activated FGFR3 binds FRS2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380780", "l": "Activation of Src (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61192", "l": "(E)-4-coumaroyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] = CoA + H(+) + myricetin 3-O-[(6-O-(E)-4-coumaroyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55607", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-acyl-sphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-acylsphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65792", "l": "fluometuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-[3-(trifluoromethyl)phenyl]-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12268", "l": "2-oxoglutarate + putrescine = 1-pyrroline + H2O + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432688", "l": "trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12244", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + FADH2 = (6S)-5,6,7,8-tetrahydrofolate + dTMP + FAD + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48303", "l": "H2O + prostaglandin F2alpha 1-glyceryl ester <=> glycerol + H(+) + prostaglandin F2alpha"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5340226", "l": "CYGB dioxygenates NO (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941701", "l": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31686", "l": "prosolanapyrone III <=> (-)-solanapyrone A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10342", "l": "(-)-vetispiradiene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3159232", "l": "Recruitment Of HIV Virion Budding Machinery (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73797", "l": "FAICAR => IMP + H2O (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42226", "l": "AH2 + androst-4-ene-3,17-dione => A + testosterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46563", "l": "2 [Fe(II)-cytochrome b5] + episterol + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + ergosta-5,7,24(28)-trien-3beta-ol + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46650", "l": "androst-4-ene-3,17-dione + propanoyl-CoA => 17-hydroxy-3-oxochol-4-en-22-oyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1222491", "l": "Lactoferrin scavenges iron ions (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.16"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55503", "l": "ent-cassa-12,15-dien-2beta,3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62984", "l": "H2O + hexadecanamide = hexadecanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29609", "l": "H(+) + NADH + 2 nitric oxide => H2O + NAD(+) + nitrous oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694409", "l": "Nucleotide exchange on RAB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14639", "l": "adenosine 3',5'-bisphosphate + H(+) + S-alkyl thiosulfate => 3'-phosphoadenylyl sulfate + a thiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31411", "l": "a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59045", "l": "dammarenediol-II + UDP-alpha-D-glucose => (20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17835", "l": "3-hydroxy-4-methylanthranilate + H(+) + S-adenosyl-L-homocysteine => 3-hydroxyanthranilate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52749", "l": "alpha-isomaltosyl-(1->3)-isomaltose + H2O => 2 isomaltose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1973968", "l": "Beta-defensins 4A and 103 bind CCR2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35931", "l": "2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-glucose = 3''-deamino-3''-hydroxykanamycin X + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1254251", "l": "ERBB4s80 binds YAP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26260", "l": "dehydroabietadienol + H(+) + NADPH + O2 <=> dehydroabietadienal + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49758", "l": "CO2 + H2O + proviolacein => H(+) + O2 + protoviolaceinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41806", "l": "(3R)-hydroxybutanoyl-[ACP] + NADP(+) => 3-oxobutanoyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55831", "l": "cortisol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22759", "l": "a long-chain primary fatty alcohol + O2 <=> a long-chain fatty aldehyde + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684052", "l": "PIAS4 SUMOylates MDC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66811", "l": "5-aminopentanoate + acetyl-CoA + 17 H(+) + 7 malonyl-CoA + 11 NADPH <=> 7 CO2 + 8 CoA + 6 H2O + 11 NADP(+) + wortmanamide A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32090", "l": "[4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphoenolpyruvate <=> [4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-(S)-4,6-CH3(COO(-))C-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30503", "l": "H2O + N-acetyl-L-glutamate 5-semialdehyde = acetate + L-glutamate 5-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28896", "l": "cadaverine(in) + L-lysine(out) => cadaverine(out) + L-lysine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388503", "l": "Oxytocin receptor bind oxytocin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23827", "l": "(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) <=> 2,3-dihydroxybenzoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008579", "l": "JUN kinase phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8960973", "l": "RLBP1:11cRAL dissociates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21526", "l": "(2S)-2-isopropylmalate + CoA + H(+) => 3-methyl-2-oxobutanoate + acetyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177284", "l": "PKA phosphorylates PDE4B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798304", "l": "TP53 binds the E2F7 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62345", "l": "6-hydroxydeoxybrevianamide E + dimethylallyl diphosphate => diphosphate + notoamide S"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549467", "l": "Expression of CRYPTOCHROME-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57811", "l": "1-chloro-3-nitrobenzene + NADH + O2 <=> 3-chlorocatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004073", "l": "aspartate-semialdehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2328037", "l": "Fibrillin-1 binds integrins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21361", "l": "ATP + beta-nicotinamide D-ribonucleotide + H(+) => diphosphate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705145", "l": "TBK1, IKBKE form homodimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954082", "l": "E2F6 binds the PRC1 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47238", "l": "(2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein] => eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.383", "l": "\"Ketol-acid reductoisomerase (NAD(P)(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29340", "l": "(S)-malate(in) + 2 H(+)(in) => (S)-malate(out) + 2 H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59142", "l": "AMP + diphosphate + H(+) + staphyloferrin A => ATP + citrate + N(5)-[(S)-citryl]-D-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33450", "l": "4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) <=> 4-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805205", "l": "GPR35 binds kynurenic acid (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39846", "l": "1,3-diacyl-sn-glycerol + an acyl-CoA <=> a triacyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-376122", "l": "DSCAM/DSCAML1 homodimerization (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62664", "l": "(2'R)-atrovenetin + S-adenosyl-L-methionine = deoxyherqueinone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37154", "l": "(9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate <=> 1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.3.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34051", "l": "2'''-acetyl-6'''-hydroxyneomycin C + H2O = 6'''-deamino-6'''-hydroxyneomycin C + acetate"}, {"i": "EC:3.5.1.113", "l": "\"2'''-acetyl-6'''-hydroxyneomycin C deacetylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9733969", "l": "Bile salts dissociate from FABP6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373747", "l": "Phosphorylation of nephrin by FYN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42643", "l": "a 2-demethylmenaquinol + S-adenosyl-L-methionine <=> a menaquinol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851842", "l": "MUC20 binds MET and inhibits GRB2 binding (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1237129", "l": "Acireductone is created (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-156930", "l": "GTP-binding activates eEF2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944255", "l": "Association of procollagen type VII (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730847", "l": "Hydrolysis of PIP2 by PLCG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33341", "l": "CoA + H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + hexacosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102308", "l": "erythromycin D 3''-o-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62786", "l": "bifonsecin B + 2 H2O + NADP(+) => 2 fonsecin B + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12904", "l": "D-arginine + H2O <=> D-ornithine + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.66", "l": "\"Calicivirin\""}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005347", "l": "ATP transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174070", "l": "Association of Cdh1 with the APC/C (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46350", "l": "3-hydroxyoctanoyl-CoA => (2E)-octenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8931981", "l": "RUNX1 binds ESR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000074", "l": "TCII binds Cbl in the circulation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18437", "l": "4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)"}, {"i": "EC:2.7.1.148", "l": "\"4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34468", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + valerena-4,7(11)-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19820", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56377", "l": "3-bromo-4,5-dihydroxybenzoate + bromide + 3 H(+) + NADPH + O2 => 3,5-dibromobenzene-1,2-diol + CO2 + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21196", "l": "5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801687", "l": "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64017", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-Glc + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928584", "l": "p-EPHs bind SRC,FYN,YES,LYN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52684", "l": "NAD(+) + pyridoxine = H(+) + NADH + pyridoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48225", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O => a neolactoside nLc4Cer(d18:1(4E)) + L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448629", "l": "IL33 binds IL1RL1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647978", "l": "pro-RAS proteins are farnesylated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27763", "l": "CTP + H2O => CMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371582", "l": "HSBP1 binds HSF1 trimer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32430", "l": "(1R,4S)-isodihydrocarvone + A <=> (S)-carvone + AH2"}]}
{"type": "biolink:MolecularActivity", "ic": "65.166422153683129", "identifiers": [{"i": "GO:0016702", "l": "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59366", "l": "1-octadecanoyl-sn-glycero-3-phosphoserine + 9,10-epoxyoctadecanoate + H(+) => 1-octadecanoyl-2-(9,10-epoxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32046", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate <=> 2 ATP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36290", "l": "H(+) + NADPH + O2 + theobromine <=> 7-methylxanthine + formaldehyde + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35896", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35774", "l": "5-deoxy-5-amino-3-dehydroshikimate <=> 3-amino-5-hydroxybenzoate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042911", "l": "acridine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54608", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] = a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694442", "l": "CNIH2,3 bind GRIA1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018774", "l": "RHOBTB1 binds GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36656", "l": "desmethyldescarbamoylnovobiocin + S-adenosyl-L-methionine => descarbamoylnovobiocin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23319", "l": "2'-deoxyuridine + 2-oxoglutarate + O2 <=> 2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65887", "l": "2-oxoglutarate + 3-hydroxy-L-kynurenine <=> H2O + L-glutamate + xanthurenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61591", "l": "amicoumacin A + ATP <=> ADP + amicoumacin A 2-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20639", "l": "D-glucono-1,5-lactone + D-sorbitol => D-fructose + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211983", "l": "CYP2J2 oxidises ARA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51427", "l": "a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O <=> ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46062", "l": "(5Z,11E)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (11E)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54795", "l": "[nsP1 protein]-L-histidine + N(7)-methyl-GTP <=> [nsP1 protein]-N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidine + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33136", "l": "malonate(in) + Na(+)(in) => malonate(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015251", "l": "ammonium channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53955", "l": "4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate <=> 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42023", "l": "11-dehydrocorticosterone + NAD(+) <=> H(+) + NADH + pregn-4-ene-3,11,20,21-tetraone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27733", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli) <=> beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70692", "l": "ornithine => putrescine + CO2 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60331", "l": "L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44257", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36717", "l": "an N-tetracosenoylsphinganine + CoA + H(+) => sphinganine + tetracosenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627089", "l": "CASP9 is phosphorylated at T125 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52937", "l": "3-oxobutanoyl-[ACP] + acetyl-[ACP] + H2O => (3S)-hydroxy-3-methylglutaryl-[ACP] + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981926", "l": "RAC1 and CDC42 activate PAK3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58747", "l": "H2O + N(7)-methyl-GTP <=> diphosphate + H(+) + N(7)-methyl-GMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50876", "l": "a hydroperoxy polyunsaturated fatty acid + H(+) + NADPH = a hydroxy polyunsaturated fatty acid + H2O + NADP(+)"}, {"i": "EC:1.11.1.22", "l": "\"Hydroperoxy fatty acid reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54385", "l": "a 3-oxo-5alpha-steroid + NADP(+) => a 3-oxo-Delta(4)-steroid + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035133", "l": "NR1H2,3 binds the CETP gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33221", "l": "gibberellin A12 + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31427", "l": "(2E,6E)-farnesyl diphosphate = (-)-exo-alpha-bergamotene + diphosphate"}, {"i": "EC:4.2.3.81", "l": "\"Exo-alpha-bergamotene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19403", "l": "formaldehyde + H(+) + NADH => methanol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909738", "l": "SHP1 and SHP2 bind the common beta chain (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.99.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186765", "l": "PLC-gamma binds to the active receptor (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507868", "l": "Aquaporins passively transport water into cells (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27393", "l": "2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 = dichlorochromopyrrolate + H(+) + 2 H2O + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46238", "l": "2 [Fe(III)-cytochrome b5] + a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O => 2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391211", "l": "Trace amine-associated receptors can bind trace amines (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "80.661393760018115", "identifiers": [{"i": "GO:0140296", "l": "general transcription initiation factor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48909", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199203", "l": "PANK1/3/4 phosphorylate PanK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35851", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50008", "l": "6-methylpretetramide + 2 H(+) + NADPH + O2 = 4-hydroxy-6-methylpretetramide + H2O + NADP(+)"}, {"i": "EC:1.14.13.232", "l": "\"6-methylpretetramide 4-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.11", "l": "\"Xaa-Pro dipeptidyl-peptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209925", "l": "DIT and MIT combine to form triiodothyronine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14734", "l": "Ag(+)(in) + ATP + H2O => ADP + Ag(+)(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193700", "l": "p75NTR ICD signals to NF-kB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-741411", "l": "CYLD deubiquitinates NEMO (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388833", "l": "Phosphorylation of CTLA-4 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49428", "l": "CTP + phosphonoformate = CMP-5'-phosphonoformate + diphosphate"}, {"i": "EC:2.7.7.93", "l": "\"Phosphonoformate cytidylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800798", "l": "The PIDDosome binds CASP2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40590", "l": "H2O + octanedioyl-CoA <=> CoA + H(+) + octanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65903", "l": "3-hydroxy-L-kynurenine + glyoxylate <=> glycine + H2O + xanthurenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9650165", "l": "ASIC trimers bind H+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951977", "l": "Acetylated RUNX3 binds to BRD2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46056", "l": "(11E)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (11E,13Z)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72621", "l": "Ribosomal scanning  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0015141", "l": "succinate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.98.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59357", "l": "H2O + lactobiono-1,5-lactone => H(+) + lactobionate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40494", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62046", "l": "(9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphoglycerol + H(+) => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphoglycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198508", "l": "malate + NAD+ <=> oxaloacetate + NADH + H+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034526", "l": "2-methylnaphthalene hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2059926", "l": "NPHP4 protein binds LATS proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132201", "l": "Opsonization with C3b or C4b (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38419", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O = 1,3-di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.33", "l": "\"Fruit bromelain\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54233", "l": "1,2-dioctanoyl-sn-glycerol + CDP-choline => 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351207", "l": "Spermine  => N-acetylated spermine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0016436", "l": "rRNA (uridine) methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3229181", "l": "CALM1:Ca2+ binds CNG channel (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32702", "l": "(2E,6E)-farnesyl diphosphate <=> beta-sesquiphellandrene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944216", "l": "Association of procollagen type XV (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59492", "l": "(2E)-geranyl diphosphate + L-tryptophyl-[protein] = (2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44914", "l": "(3E)-hexenoyl-CoA + NADP(+) => (2E,4E)-hexadienoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807214", "l": "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72621", "l": "Ribosomal scanning  (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2514865", "l": "cGMP dissociates from CNG channels (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41079", "l": "1-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6804955", "l": "ATM phosphorylates MDM2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450533", "l": "PKCdelta phosphorylates HuR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65614", "l": "a 21-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2301205", "l": "SETD8 monomethylates histone H4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3769394", "l": "AKT phosphorylates CBY1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203700", "l": "eNOS translocation from Golgi to Caveolae (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799097", "l": "ATM phosphorylates ZNF420 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102355", "l": "2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38434", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O <=> (9Z)-octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11109", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate => n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65177", "l": "A + protoaustinoid A => AH2 + protoaustinoid B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57150", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25113", "l": "H2O + pyridoxine 5'-phosphate => phosphate + pyridoxine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008932", "l": "lytic endotransglycosylase activity"}, {"i": "EC:2.4.99.-", "l": "\"Transferring other glycosyl groups\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977228", "l": "Sialyltransferase I can add sialic acid to the T antigen at the alpha 6 position (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909765", "l": "Mitochondrial uptake of beta-alanine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42983", "l": "L-tyrosine <=> 2-aminoprop-2-enoate + phenol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060422", "l": "peptidyl-dipeptidase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "70.245698090881746", "identifiers": [{"i": "GO:0004896", "l": "cytokine receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008076", "l": "WWP1 polyubiquitinates RUNX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23563", "l": "adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate <=> adenosylcob(III)alamin 5'-phosphate + GMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51800", "l": "deoxyadlupulone + dimethylallyl diphosphate = adlupulone + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194678", "l": "CYP51A1 demethylates LNSOL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0019119", "l": "phenanthrene-9,10-epoxide hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013159", "l": "CDC42 GEFs activate CDC42 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21453", "l": "a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 => a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983156", "l": "Polyubiquitination of substrate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616368", "l": "MyrG-CDK5R1,2 bind CDK5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-168136", "l": "Activated JNKs phosphorylate c-JUN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62101", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045506", "l": "interleukin-24 receptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "82.428592223071533", "identifiers": [{"i": "GO:0004112", "l": "cyclic-nucleotide phosphodiesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45939", "l": "3-methylundecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(4-methyl-2-oxododecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33638", "l": "ATP + CoA + docosanoate <=> AMP + diphosphate + docosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36703", "l": "(2S,5S)-5-carboxymethylproline + ATP = (3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+)"}, {"i": "EC:6.3.3.6", "l": "\"Carbapenam-3-carboxylate synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036412", "l": "acetyl-CoA:oxalate CoA-transferase"}, {"i": "RHEA:37883", "l": "acetyl-CoA + oxalate = acetate + oxalyl-CoA"}, {"i": "EC:2.8.3.19", "l": "\"CoA:oxalate CoA-transferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64329", "l": "(7Z)-octadecenoyl-CoA + cholesterol => cholesteryl (7Z)-octadecenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610802", "l": "GluN3A (GRIN3A), GluN3B (GRIN3B) NMDA receptors traffic to the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353526", "l": "Repair of ~27-30 bp long patch by DNA Pol Epsilon (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54751", "l": "ATP + CoA + firefly L-luciferin <=> AMP + diphosphate + L-firefly luciferyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18068", "l": "ATP + H2O + phosphonate(out) <=> ADP + H(+) + phosphate + phosphonate(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050515", "l": "4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31447", "l": "6-amino-2-oxohexanoate + H2O2 = 5-aminopentanoate + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1299297", "l": "Activation of THIK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030598", "l": "rRNA N-glycosylase activity"}, {"i": "MetaCyc:3.2.2.22-RXN"}, {"i": "EC:3.2.2.22", "l": "\"rRNA N-glycosylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53784", "l": "beta-muricholate + deoxycholoyl-CoA = beta-muricholoyl-CoA + deoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62135", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dTTP <=> a 2'-deoxyribonucleoside 5'-diphosphate + dTDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27510", "l": "7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine = dehydro coenzyme F420-0 + GMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3341294", "l": "Superoxide reduces cytochrome c (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373741", "l": "SDK2 homophillic interaction (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34310", "l": "4-nitrocatechol + NADPH + O2 <=> 2-hydroxy-1,4-benzoquinone + H2O + NADP(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627369", "l": "SEPT4 binds XIAP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55907", "l": "7-chloro-L-tryptophan + chloride + FADH2 + O2 <=> 6,7-dichloro-L-tryptophan + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63374", "l": "an S-acyl-L-cysteinyl-[protein] + CoA => an acyl-CoA + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62963", "l": "cholesta-5,7-dien-3beta-ol(in) <=> cholesta-5,7-dien-3beta-ol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36818", "l": "dTDP-alpha-D-fucose <=> dTDP-alpha-D-fucofuranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51013", "l": "a monoacyl-sn-glycero-3-phosphocholine + H2O => a monoacylglycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54387", "l": "a 3-oxo-5alpha-steroid + NADP(+) <=> a 3-oxo-Delta(4)-steroid + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34842", "l": "4 H(+) + 5 malonyl-CoA <=> 5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO2 + 5 CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114284", "l": "Release of Cytochrome c from mitochondria (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73806", "l": "AIR + CO2 => CAIR (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009371", "l": "Binding of AP1 transcriptional activator complexes to CCND1 promoter (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102794", "l": "cinnamaldehyde:oxygen oxidoreductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798528", "l": "S100A8:S100A9 binds Mn2+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32043", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = 2 ATP + 2 H(+)"}, {"i": "EC:3.6.1.61", "l": "\"Diadenosine hexaphosphate hydrolase (ATP-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111879", "l": "PIP2 hydrolysis (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28337", "l": "dATP + H2O <=> dAMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102606", "l": "octat-9-en-7-ol 5-monooxygenase activity"}, {"i": "RHEA:56820", "l": "AH2 + cyclooctat-9-en-7-ol + O2 = A + cyclooctat-9-ene-5,7-diol + H2O"}, {"i": "MetaCyc:RXN-15431"}, {"i": "EC:1.14.99.61", "l": "\"Cyclooctat-9-en-7-ol 5-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44686", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.4", "l": "\"Acyl-lipid (11-3)-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35445", "l": "an anthocyanidin 3-O-beta-D-sambubioside + 2 H(+) + UDP => an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-xylose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944352", "l": "TCF/LEF binds WNT promoters (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43330", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48605", "l": "2,3-dihydroxybenzoyl-5'-AMP + holo-[EntB isochorismatase/aryl-carrier protein] => 2,3-dihydroxybenzoyl-[EntB isochorismatase/aryl-carrier protein] + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18311", "l": "a carboxylate + a D-alpha-amino acid => an N-acyl-D-amino acid + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706350", "l": "FLT3 phosphorylates CBL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47615", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57537", "l": "a ribonucleoside 5'-triphosphate + adenosine-5'-diphospho-5'-ribonucleotide-RNA => 5'-NTP-ribonucleotide-RNA + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61451", "l": "H(+) + NADPH + O2 + tigecycline <=> 11a-hydroxytigecycline + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22010", "l": "CoA + O-succinyl-L-homoserine => L-homoserine + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50866", "l": "9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O => (9Z,12Z)-octadecadienoate + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050536", "l": "(S)-N-acetyl-1-phenylethylamine hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13622", "l": "4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose => 1-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59212", "l": "holo-[(hydroxy)phthioceranic acid synthase] + octadecanoyl-AMP = AMP + H(+) + octadecanoyl-[(hydroxy)phthioceranic acid synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19427", "l": "5-hydroxyimidazole-4-acetate + H2O + NAD(+) => H(+) + imidazole-4-acetate + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047685", "l": "amine sulfotransferase activity"}, {"i": "MetaCyc:ARYLAMINE-SULFOTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0015185", "l": "gamma-aminobutyric acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047351", "l": "guanosine-triphosphate guanylyltransferase activity"}, {"i": "MetaCyc:2.7.7.45-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034823", "l": "citronellyl-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60844", "l": "a 5'-end diphospho-guanosine in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38647", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50669", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28229", "l": "(+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805035", "l": "TP53 binds STK11 and NUAK1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40392", "l": "1-O-alkyl-2-acyl-sn-glycerol + an acyl-CoA => 1-O-alkyl-2,3-diacyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654637", "l": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63078", "l": "2-acetylphloroglucinol + 3 CO2 + 4 CoA => acetyl-CoA + 3 H(+) + 3 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48968", "l": "[thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2 = [thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008545", "l": "JUN kinase kinase activity"}, {"i": "REACT:R-HSA-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654573", "l": "Activated FGFR1 binds SHC1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0031739", "l": "cholecystokinin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25100", "l": "ADP + UTP => ATP + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59664", "l": "D-cellopentaose + O2 = D-cellopentaono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60763", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-jasmololone <=> CoA + jasmolin II"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42076", "l": "2-hydroxyglutarate + acetyl-CoA = 2-hydroxyglutaryl-CoA + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32542", "l": "(2E)-geranyl diphosphate <=> (+)-car-3-ene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48367", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose <=> beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47173", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NAD(+) => 5alpha-cholest-8-en-3-one + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854981", "l": "SHC1 in the RET complex is phosphorylated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10181", "l": "(6S)-10-formyltetrahydrofolate + H2O + NADP(+) => (6S)-5,6,7,8-tetrahydrofolate + CO2 + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27566", "l": "(2E)-geranyl diphosphate + 7 isopentenyl diphosphate <=> all-trans-nonaprenyl diphosphate + 7 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66108", "l": "2-oxobutanoate + L-cysteine = (2S)-2-aminobutanoate + 2-oxo-3-sulfanylpropanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854645", "l": "IL22:IL22RA1:JAK1 binds IL10RB:TYK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57998", "l": "(20S)-ginsenoside Rh2 + H(+) + UDP => (20S)-protopanaxadiol + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-109701", "l": "PDPK1 binds PIP3 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015551", "l": "3-hydroxyphenyl propanoate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9679044", "l": "FKBP1A binds sirolimus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54196", "l": "N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45783", "l": "(9Z)-octadecenoyl-CoA + di-(9Z)-octadecenoylglycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-517674", "l": "p-S158,221-HuR binds mRNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004997", "l": "thyrotropin-releasing hormone receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654167", "l": "Activated FGFR1 binds PLCG1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5323526", "l": "FRAT proteins bind GSK3beta (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25124", "l": "(S)-2-amino-6-oxohexanoate <=> H(+) + H2O + L-1-piperideine-6-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000103", "l": "CUBN:AMN binds CBLIF:Cbl (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59025", "l": "H2O + trihexadecanoylglycerol => dihexadecanoylglycerol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32494", "l": "(1E,4E,8E)-alpha-humulene + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxy-alpha-humulene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617735", "l": "TXN disrupts FOXO4 complex with EP300 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21567", "l": "acetyl-CoA + an acyl-CoA <=> a 3-oxoacyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9035484", "l": "CysS248-MPST:TXN2 dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26233", "l": "(2E,6E,10E)-geranylgeraniol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + plaunotol"}, {"i": "EC:1.14.14.146", "l": "\"Geranylgeraniol 18-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50314", "l": "butanal + CO2 => 2-oxopentanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46783", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27686", "l": "ATP + GDP = ADP + GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53890", "l": "alpha,alpha-trehalose 6-phosphate + H(+) + TDP => D-glucose 6-phosphate + TDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865605", "l": "BRWD1 binds SMARCA4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43884", "l": "3-oxochol-4-en-22-oyl-CoA + NAD(+) = 3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949580", "l": "F1Fo ATP synthase dimerizes (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632412", "l": "PTK2 is recruited to methylated ESR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13089", "l": "6 [Fe(III)cytochrome c] + 2 H2O + NH4(+) = 6 [Fe(II)cytochrome c] + 8 H(+) + nitrite"}, {"i": "EC:1.7.2.2", "l": "\"Nitrite reductase (cytochrome; ammonia-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58430", "l": "(E,E)-2,4-hexadienal + H(+) + NADPH => (E,E)-2,4-hexadien-1-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782311", "l": "ADAT2:ADAT3 (hetADAT) deaminates adenosine-34 in tRNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18936", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA <=> (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419049", "l": "ROCK activation by RHO (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45749", "l": "(3Z)-hexenoyl-CoA => (2E)-hexenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39671", "l": "(9Z)-hexadecenoyl-CoA + AH2 + O2 = (9Z,12Z)-hexadecadienoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14735", "l": "ADP + Ag(+)(out) + H(+) + phosphate => Ag(+)(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43322", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine => 1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015131", "l": "oxaloacetate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29881", "l": "ADP + H(+) + L-arginine(in) + phosphate => ATP + H2O + L-arginine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60098", "l": "4alpha-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADPH => 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5252001", "l": "ATP1B4 binds SNW1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33880", "l": "2-deoxy-scyllo-inosamine + NADP(+) => 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164512", "l": "Second strand transfer by annealing complementary PBS sequences (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42775", "l": "guanosine(1405) in 16S rRNA + S-adenosyl-L-methionine <=> N(7)-methylguanosine(1405) in 16S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417896", "l": "P2Y6 receptor can bind to UDP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396009", "l": "STING binds c-di-GMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54625", "l": "2-oxoglutarate + O2 + octadecanoyl-CoA => 2-hydroxyoctadecanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27844", "l": "2'-aminobiphenyl-2,3-diol + NADP(+) => 9H-carbazole + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14113", "l": "(DNA)-3'-(deoxyribonucleoside 3',5'-bisphosphate) + H2O = (DNA)-3'-(deoxyribonucleoside 5'-phosphate) + phosphate"}, {"i": "EC:3.1.3.32", "l": "\"Polynucleotide 3'-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65784", "l": "2 H(+) + monuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-(4-chlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47989", "l": "2-dehydro-3-deoxy-L-galactonate + NAD(+) => 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865320", "l": "CBFB binds RUNX1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009030", "l": "thiamine-phosphate kinase activity"}, {"i": "RHEA:15913", "l": "ATP + thiamine phosphate = ADP + thiamine diphosphate"}, {"i": "EC:2.7.4.16", "l": "\"Thiamine-phosphate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52304", "l": "H2O + L-ectoine = (2S)-2-acetamido-4-aminobutanoate"}, {"i": "EC:3.5.4.44", "l": "\"Ectoine hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.46", "l": "\"Galactan 5-O-arabinofuranosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27558", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 2 isopentenyl diphosphate <=> all-trans-hexaprenyl diphosphate + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042008", "l": "interleukin-18 receptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047420", "l": "N-acyl-D-amino-acid deacylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.20", "l": "\"Alpha-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42190", "l": "5alpha-androstan-3,17-dione + H(+) + NADH => 3beta-hydroxy-5alpha-androstan-17-one + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031783", "l": "type 5 melanocortin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174070", "l": "Association of Cdh1 with the APC/C (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050407", "l": "[glycogen-synthase-D] phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49748", "l": "2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate = CO2 + 2 H2O + NADP(+) + proviolacein"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36480", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA => (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.27"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52395", "l": "ATP + D-erythronate <=> 4-phospho-D-erythronate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58165", "l": "(2E,6E)-farnesyl diphosphate + 2 H2O => 7-epi-ent-eudesmane-5,11-diol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5627072", "l": "RHOQ binds GOPC:CFTR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10733", "l": "ATP + firefly D-luciferin + O2 => AMP + CO2 + diphosphate + firefly oxyluciferin + hnu"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0047936", "l": "glucose 1-dehydrogenase [NAD(P)] activity"}, {"i": "MetaCyc:GLUCOSE-1-DEHYDROGENASE-RXN"}, {"i": "EC:1.1.1.47", "l": "\"Glucose 1-dehydrogenase (NAD(P)(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371422", "l": "ATP hydrolysis by HSP70 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420206", "l": "Phosphorylation of SRC-1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4332359", "l": "Active calmodulin binds CAMK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57964", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.168", "l": "\"Germacreene A acid 8-beta-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29452", "l": "H2O + phosphonate => H2 + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41120", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25720", "l": "H(+) + N,N-dihydroxy-L-trihomomethionine => (E)-6-(methylsulfanyl)hexanal oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14177", "l": "(R)-amygdalin + H2O = (R)-prunasin + D-glucose"}, {"i": "EC:3.2.1.117", "l": "\"Amygdalin beta-glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865098", "l": "UBA6 conjugates ubiquitin to UBA6 in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13863", "l": "D-xylono-1,5-lactone + H(+) + NADH => D-xylose + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60803", "l": "2-oxoglutarate + gibberellin A53 + O2 <=> CO2 + gibberellin A44 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23344", "l": "a purine D-ribonucleoside + H2O = a purine nucleobase + D-ribose"}, {"i": "EC:3.2.2.1", "l": "\"Purine nucleosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65680", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontenoyl)-sphing-4-enine = a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097713", "l": "dolichol-phosphate-mannose synthase regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029680", "l": "Caspase-7 translocates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782224", "l": "3' incision by ERCC5 (XPG) in TC-NER (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0005221", "l": "intracellular cyclic nucleotide activated cation channel activity"}, {"i": "REACT:R-HSA-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40387", "l": "1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP = 1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110219", "l": "Cleavage of thymine by TDG glycosylase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63062", "l": "2,4-dihydroxy 5,6-dimethylbenzaldehyde + AMP + diphosphate + NADP(+) => 5-methylorsellinate + ATP + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65587", "l": "(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] <=> 8-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67088", "l": "ATP + H2O + tetracosanoate(in) = ADP + H(+) + phosphate + tetracosanoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-378975", "l": "Follitropin is a heterodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60859", "l": "a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38999", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O = a 1-acyl-sn-glycero-3-phosphate + H(+) + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497794", "l": "Salvage - BH2 is reduced to BH4 by DHFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19895", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43474", "l": "14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46847", "l": "4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5662466", "l": "XYLB phosphorylates D-xylulose (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37283", "l": "H2O + L-alanyl-L-histidine = L-alanine + L-histidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807565", "l": "GNLY is transferred to the phagosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56856", "l": "A + an aldehyde + H2O = a carboxylate + AH2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54764", "l": "5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine = [LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903876", "l": "11-deoxycortisol binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18396", "l": "(R)-3-amino-2-methylpropanoate + pyruvate <=> 2-methyl-3-oxopropanoate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42138", "l": "a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981353", "l": "RASA1 stimulates RAS GTPase activity (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432143", "l": "PECAM-1 binds PP2A (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848316", "l": "IL36 binds IL1RL2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33243", "l": "L-tetrahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-7-(methylsulfanyl)heptanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56432", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5671702", "l": "AP1G2 binds HGS and CHMP2A (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51939", "l": "2-(glutathione-S-yl)-hydroquinone + glutathione <=> glutathione disulfide + hydroquinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10217", "l": "[DNA-directed RNA polymerase] + ATP => ADP + H(+) + phospho-[DNA-directed RNA polymerase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24063", "l": "N-hydroxy-L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-190829", "l": "Lysosomal degradation of gap junction plaques (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430158", "l": "p-SLP-76 binds VAV (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1462041", "l": "HNP1-4 are released into phagocytic vacuoles (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38120", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol => 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858428", "l": "FCAMR binds IgA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56406", "l": "(3R)-hydroxybutanoate pentamer + [(3R)-hydroxybutanoate](n-5) + H(+) => [(3R)-hydroxybutanoate](n) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2002440", "l": "Removal of fibrillar collagen C-propeptides (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008810", "l": "cellulase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16603", "l": "fumarate + NH4(+) => L-aspartate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050302", "l": "indole-3-acetaldehyde oxidase activity"}, {"i": "KEGG.REACTION:R02681"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2471670", "l": "Defective RDH12 does not reduce atRAL to atROL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75096", "l": "Docking of the TAP:EJC Complex with the NPC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951644", "l": "Release of mature NEDD8 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70501", "l": "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64538", "l": "a 1,2-diacyl-sn-glycerol + a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.14"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62746", "l": "(S)-2-methylbutanoate + compactin diol lactone + H(+) => H2O + mevastatin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42750", "l": "5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(967) in 16S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13497", "l": "5-dehydro-2-deoxy-D-gluconate + ATP = 6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+)"}, {"i": "EC:2.7.1.92", "l": "\"5-dehydro-2-deoxygluconokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22525", "l": "2 A + a carotenoid beta-end derivative => a carotenoid phi-end derivative + 2 AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32715", "l": "(2R,3S)-3-methylmalate + NAD(+) = 2-oxobutanoate + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195378", "l": "Homodimerization of VEGF proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018859", "l": "4-hydroxybenzoate-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690785", "l": "BAP1 binds Ub-HCFC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210881", "l": "Dimerization of Tie2/Ang1 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46184", "l": "ATP + CoA + isovalerate = 3-methylbutanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65081", "l": "asperaculane D + O2 + reduced [NADPH--hemoprotein reductase] => asperaculane E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56210", "l": "3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+) => CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39908", "l": "2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose => dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43737", "l": "adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782820", "l": "USP17 deubiquitinates SUDS3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45311", "l": "H(+) + NADPH + prostaglandin D2-ethanolamide <=> 11beta-prostaglandin F2-ethanolamide + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050377", "l": "UDP-glucose 4,6-dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60324", "l": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.359", "l": "\"[Histone H3]-lysine(36) N-trimethyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40883", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + FAD + H(+) = (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411351", "l": "TCF/LEF:CTNNB1 bind the AXIN2 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426489", "l": "RISC binds inexactly matching target RNAs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451758", "l": "p85 associates with both p-Nephrin and CD2AP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50826", "l": "14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50329", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] => 1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432428", "l": "Cytosolic CRY is degraded by the 26S proteasome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42435", "l": "3-hydroxy-cis,cis-muconate <=> maleylacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37576", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine => 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53181", "l": "D-erythrose => D-erythrulose"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0072328", "l": "alkene binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.2.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66851", "l": "2 Cu(2+) + NADH <=> 2 Cu(+) + H(+) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013024", "l": "RHOB binds effectors at the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59139", "l": "ATP + citrate + D-ornithine <=> AMP + diphosphate + H(+) + N(5)-[(S)-citryl]-D-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23193", "l": "Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692781", "l": "p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202203", "l": "Recruitment of PI3K to plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30777", "l": "H2O2 + NH4(+) + pyridoxal => H2O + O2 + pyridoxamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35720", "l": "(3S)-versiconol acetate + H2O => (S)-versiconol + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44995", "l": "(R)-carnitine + 2-methylbutanoyl-CoA <=> CoA + O-2-methylbutanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16837", "l": "5'-acylphosphoadenosine + H2O = a carboxylate + AMP + 2 H(+)"}, {"i": "EC:3.6.1.20", "l": "\"5'-acylphosphoadenosine hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625540", "l": "Cys-sulfenyl chloride is converted to Cys-sulfenic acid (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46399", "l": "2 [Fe(II)-cytochrome b5] + an 11,12-saturated fatty acyl-CoA + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + an (11E)-Delta(11)-fatty acyl-CoA + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58462", "l": "a monoacyl-sn-glycero-3-phosphocholine + CoA => an acyl-CoA + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198270", "l": "PDPK1 phosphorylates AKT at T308 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043999", "l": "histone acetyltransferase activity (H2A-K5 specific)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0009982", "l": "pseudouridine synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36592", "l": "(S)-2-chloropropanoate + NADP(+) => 2-chloroacrylate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690785", "l": "BAP1 binds Ub-HCFC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18359", "l": "H(+) + NADPH + tropinone => NADP(+) + tropine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19398", "l": "(R)-4'-phosphopantothenate + CTP + L-cysteine => CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29136", "l": "a menaquinol + 2 H(+)(in) + nitrate => a menaquinone + 2 H(+)(out) + H2O + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858506", "l": "Defective GYS2 does not transfer glucose to growing glycogen chains (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60247", "l": "2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] <=> 2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29884", "l": "ATP + H2O + L-ornithine(out) => ADP + H(+) + L-ornithine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61952", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl-[protein] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710106", "l": "ELANE cleaves GSDMD (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655733", "l": "Defective SLC40A1 does not transport Fe2+ from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15620", "l": "[Fe(II)cytochrome c] + Fe(3+) <=> [Fe(III)cytochrome c] + Fe(2+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49538", "l": "(2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O => 2-amino-2-deoxy-D-gluconate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36869", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-166015", "l": "Association of LBP with LPS (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15259", "l": "acetaldehyde + glycine => D-threonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848663", "l": "ADIPOQ trimer binds ADIPOR dimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32989", "l": "a carboxylate + H(+) + sn-glycero-3-phospho-1D-myo-inositol => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072541", "l": "peroxynitrite reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852331", "l": "GTSE1 translocates to the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63120", "l": "(11Z)-eicosenamide + H2O = (11Z)-eicosenoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44571", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + H(+) <=> 2-all-trans-hexaprenylphenol + CO2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046526", "l": "D-xylulose reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730736", "l": "Monofunctional chemotherapeutic alkylating drugs produce 3-methyladenine in dsDNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008883", "l": "glutamyl-tRNA reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64633", "l": "acetyl-CoA + butan-1-ol => butyl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019959", "l": "interleukin-8 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44345", "l": "ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate => ADP + dapdiamide A + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.41"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25270", "l": "(R)-noradrenaline + S-adenosyl-L-methionine => (R)-adrenaline + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30348", "l": "ATP + IDP => ADP + ITP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63294", "l": "H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1248) in human 18S rRNA + S-methyl-5'-thioadenosine => N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21923", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine <=> Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21190", "l": "AMP + diphosphate + H(+) + NAD(+) => ATP + deamido-NAD(+) + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.50"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429955", "l": "CCR4-NOT complex deadenylates mRNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1254291", "l": "ERBB4s80 binds STAT5A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015498", "l": "pantothenate:sodium symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11905", "l": "2-amino-4-hydroxypteridine + H(+) + H2O => 2,4-dihydroxypteridine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27913", "l": "D-gluconate + NAD(+) <=> 2-dehydro-D-gluconate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45491", "l": "[C-phycocyanin beta-subunit]-Cys(84)-phycocyanobilin <=> (2R,3E)-phycocyanobilin + apo-[C-phycocyanin beta-subunit]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10285", "l": "L-leucine => (3R)-beta-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56223", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15345", "l": "ATP + L-arginine + L-tyrosine = AMP + diphosphate + H(+) + L-tyrosyl-L-arginine"}, {"i": "EC:6.3.2.24", "l": "\"Tyrosine--arginine ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50474", "l": "(2-aminobenzoyl)acetyl-CoA + CO2 + CoA => anthraniloyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1964496", "l": "STING binds TRIM32 or TRIM56  (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29556", "l": "H2O + UDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + 2 H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52323", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryptamine <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + serotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23589", "l": "oxalate + succinyl-CoA => oxalyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2250301", "l": "Formation of lysyl-pyrrole cross-links (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52987", "l": "7-oxoheptanoyl-[ACP] + H2O + oxidized [flavodoxin] <=> 6-carboxyhexanoyl-[ACP] + reduced [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168136", "l": "Activated JNKs phosphorylate c-JUN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48121", "l": "ganglioside GD3 + H2O => ganglioside GM3 + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018727", "l": "2-phenanthrol sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57496", "l": "2-methylcitrate = 2-methyl-cis-aconitate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53050", "l": "2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 2-hydroxyestrone + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58071", "l": "O2 + trans-isoeugenol <=> acetaldehyde + vanillin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61137", "l": "(2R,3R)-dihydroquercetin + 2-oxoglutarate + O2 => CO2 + H(+) + H2O + quercetin + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2870221", "l": "E-selectin binds E-selectin ligand (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416358", "l": "G alpha (q) inhibits PI3K alpha (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62979", "l": "(9Z,12Z,15Z)-octadecatrienamide + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10358", "l": "5beta-androstane-3,17-dione + H(+) + NADH => 3alpha-hydroxy-5beta-androstan-17-one + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23890", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate => [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102199", "l": "nitric oxide reductase activity (NAD(P)H-dependent) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48991", "l": "NADH + O2 + rifampicin <=> 2'-N-hydroxyrifampicin + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38153", "l": "CO2 + H(+) + hydrogen sulfide => carbonyl sulfide + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5082356", "l": "HSF1-mediated gene expression (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66596", "l": "O2 + 2 tyramine = 2 dopamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483174", "l": "PE is methylated to PC by PEMT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14840", "l": "glyoxylate + H2O + O2 <=> H(+) + H2O2 + oxalate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102915", "l": "piperitol synthase activity"}, {"i": "MetaCyc:RXN-8695"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10980", "l": "L-serine = D-serine"}, {"i": "EC:5.1.1.18", "l": "\"Serine racemase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879942", "l": "The receptor is activated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673231", "l": "GGCX does not gamma-carboxylate 3D-F9(29-461) (pro-factor IX) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211983", "l": "CYP2J2 oxidises ARA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39639", "l": "(3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA = (2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55361", "l": "11-cis-retinol => 9-cis-retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59642", "l": "D-xylotetraono-1,5-lactone + H2O2 => D-xylotetraose + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46564", "l": "acetyl-CoA + apo-[ACP] = acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10647", "l": "2-oxo-2H-pyran-4,6-dicarboxylate + H2O <=> (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32498", "l": "(2E)-geraniol + O2 + reduced [NADPH--hemoprotein reductase] <=> (6E)-8-hydroxygeraniol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877192", "l": "RUNX1 binds FOXP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102962", "l": "4,4'-diapo-zeta-carotene desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430311", "l": "Rsu-1 interacts with Pinch1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205112", "l": "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15642", "l": "H(+) + oxaloacetate => CO2 + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1297444", "l": "Binding of cAMP to HCN channels (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42893", "l": "5'-deoxyadenosine + H(+) + H2O => 5'-deoxyinosine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982810", "l": "JAK2 phosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5229343", "l": "AXIN is phosphorylated in the destruction complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17391", "l": "D-ribulose + H(+) + NADH => D-arabinitol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28093", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17719", "l": "1D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 1,4,5-trisphosphate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937613", "l": "CRHBP binds CRH (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785213", "l": "LIPC dimer binds heparin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632970", "l": "MSH6 variant:MSH2-defective DNA mismatch repair (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685953", "l": "SIRT6 deacetylates RBBP8 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24207", "l": "acetyl phosphate + H(+) + sulfite <=> phosphate + sulfoacetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46160", "l": "a quinone + H(+) + NADH = a quinol + NAD(+)"}, {"i": "EC:1.6.5.11", "l": "\"NADH dehydrogenase (quinone)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009541", "l": "ESR1 binds to TFF1 gene promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102721", "l": "ubiquinol:oxygen oxidoreductase activity"}, {"i": "MetaCyc:RXN-6883"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24640", "l": "ergosteryl 3-beta-D-glucoside + H2O = D-glucose + ergosterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54287", "l": "H2O + N-(octadecanoyl)-sphing-4-enine-1-phosphocholine <=> H(+) + N-octadecanoylsphing-4-enine + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43201", "l": "cytidine(1920) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(1920) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55768", "l": "all-trans-retinoate + UDP-alpha-D-glucuronate = all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55113", "l": "4-methyl-3-oxopentanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-4-methylpentanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9640167", "l": "RRAGA,B exchanges GDP for GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53009", "l": "(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate => di-trans,poly-cis-polyprenyl diphosphate + n diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15925", "l": "dihydrobunolol + NADP(+) = bunolol + H(+) + NADPH"}, {"i": "EC:1.1.1.160", "l": "\"Dihydrobunolol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12994", "l": "cyclohex-1-ene-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => cyclohexa-1,5-diene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0061785", "l": "peptidoglycan endopeptidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58418", "l": "(E)-4-hydroxynon-2-enal + H(+) + NADPH => (E)-4-hydroxynon-2-en-1-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9609921", "l": "SGTA binds Tail-anchored protein (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161662", "l": "PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036189", "l": "abieta-7,13-diene hydroxylase activity"}, {"i": "KEGG.REACTION:R06351"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.53"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13119", "l": "3-(pyrazol-1-yl)-L-alanine + acetate + H(+) => O-acetyl-L-serine + pyrazole"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852552", "l": "MST1R autophosphorylates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18477", "l": "2,3-dihydroxybenzoate + O2 = 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)"}, {"i": "EC:1.13.11.14", "l": "\"2,3-dihydroxybenzoate 3,4-dioxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54806", "l": "4,4'-disulfanyldibutanoate + H(+) + NADH => 2 4-sulfanylbutanoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23025", "l": "[(1->4)-beta-D-glucosyl](n) + phosphate => [(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58297", "l": "25-substituted-cholesterol + beta-D-glucosyl-N-hexadecanoylsphing-4E-enine => 25-substituted-cholesteryl beta-D-glucoside + N-hexadecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55380", "l": "a 3alpha-hydroxy bile acid CoA + NAD(+) = a 3-oxo bile acid CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.37", "l": "\"Leukocyte elastase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40480", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864029", "l": "PTPN12 dephosphorylates EGFR at Y1148 (Y1172) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52609", "l": "2-hydroxybutanoate + NADP(+) => 2-oxobutanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27311", "l": "naphthalene-1,2-diol + O2 => 2-hydroxychromene-2-carboxylate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607740", "l": "PKC-delta phosphorylates CARD9 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20264", "l": "3,5,7-trioxododecanoyl-CoA <=> CO2 + CoA + olivetol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730841", "l": "Phosphorylation and activation of VAV (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050519", "l": "holo-citrate lyase synthase activity"}, {"i": "RHEA:16333", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP] = diphosphate + holo-[citrate lyase ACP]"}, {"i": "EC:2.7.7.61", "l": "\"Citrate lyase holo-[acyl-carrier protein] synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004963", "l": "follicle-stimulating hormone receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35473", "l": "(+)-pisatin + H(+) + S-adenosyl-L-homocysteine => (+)-6a-hydroxymaackiain + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218832", "l": "CDC42:GTP binds PAK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10381", "l": "diphosphate + orotidine 5'-phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + orotate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807872", "l": "Active ARF recruits coatomer (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14416", "l": "biphenyl-2,3-diol + O2 <=> 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034737", "l": "ergosterol O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.5", "l": "\"Dynamin GTPase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52557", "l": "3-dehydro-D-erythronate + ATP => 3-dehydro-4-O-phospho-D-erythronate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62150", "l": "dGDP + dTDP => dGTP + dTMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35780", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => mutildienyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31887", "l": "(S)-2,3-epoxysqualene = tirucalladienol"}, {"i": "EC:5.4.99.56", "l": "\"Tirucalladienol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18309", "l": "an N-acyl-D-amino acid + H2O = a carboxylate + a D-alpha-amino acid"}, {"i": "EC:3.5.1.81", "l": "\"N-acyl-D-amino-acid deacylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112395", "l": "Abortive termination of elongation after arrest (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696958", "l": "USP44 deubiquitinates CDC20 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.148", "l": "\"Estradiol 17-alpha-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34097", "l": "CO2 + spermidine => carboxyspermidine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033154", "l": "ABC-type oligogalacturonide transporter activity"}, {"i": "TCDB:3.A.1.1.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52745", "l": "cyclobis-(1->3)-alpha-isomaltosyl + H2O => alpha-isomaltosyl-(1->3)-isomaltose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848812", "l": "HIF1A,EPAS1 bind PTK6 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052674", "l": "ent-pimara-9(11),15-diene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202111", "l": "AKT1 phosphorylates eNOS (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42115", "l": "(20S)-hydroxypregn-4-en-3-one + NADP(+) <=> H(+) + NADPH + progesterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2129357", "l": "Fibrillin C-terminal processing (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190263", "l": "FGFR3b binds to FGF (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32341", "l": "(+)-thujan-3-one + H(+) + NADPH => (+)-thujan-3-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018771", "l": "2-hydroxy-6-oxonona-2,4-dienedioate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38226", "l": "(9Z)-octadecenoyl-CoA + decan-1-ol <=> 1-O-decyl-(9Z)-octadecenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38046", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (4Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070747", "l": "interleukin-35 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014294", "l": "RAC2 binds effectors at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34939", "l": "H2O + menaquinone-8 + selenite = menaquinol-8 + selenate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56183", "l": "8-carboxy-8-demethylriboflavin 5'-phosphate + 2 A + H2O + L-glutamate <=> 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 2 AH2 + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689111", "l": "PARK2 autoubiquitinates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12066", "l": "glutarate + 2 H(+) + NADH => 5-oxopentanoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174224", "l": "Dissociation of Cdc20 from APC/C complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205112", "l": "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5336443", "l": "LIN7, CASK and APBA1 bind (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16028", "l": "an anthocyanidin 3-O-beta-D-glucoside + malonyl-CoA <=> an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202692", "l": "PIP3 binds to RhoA and activates it (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17981", "l": "4,5alpha-dihydrocortisone + NADP(+) = cortisone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37856", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA => 1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690340", "l": "Defective ABCC6 does not transport organic anion from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28175", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => colneleate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65953", "l": "2 a quinone + H(+) + NADH => 2 a 1,4-benzosemiquinone + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102293", "l": "pheophytinase b activity"}, {"i": "MetaCyc:RXN-12686"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8864595", "l": "TFAP2B homodimer binds YEATS4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420724", "l": "CASR binds Ca2+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675656", "l": "EDA:EDAR binds EDARADD (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44420", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycero-3-phosphate + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196929", "l": "FLAD1 phosphorylates FMN (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18227", "l": "6-aminohexanoate + [N-(6-aminohexanoyl)](n-1) => [N-(6-aminohexanoyl)](n) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2317314", "l": "AKT binds PDPK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2995330", "l": "COX10 transforms heme to heme O (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693198", "l": "RHOD binds effectors at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16888", "l": "2 bilirubin-glucuronoside <=> bilirubin IXalpha + bilirubin-bisglucuronoside"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0120241", "l": "2-iminobutanoate/2-iminopropanoate deaminase"}, {"i": "RHEA:40671", "l": "2-iminopropanoate + H2O = NH4(+) + pyruvate"}, {"i": "EC:3.5.99.10", "l": "\"2-iminobutanoate/2-iminopropanoate deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60362", "l": "dehydro coenzyme F420-0 + FMNH2 => FMN + H(+) + oxidized coenzyme F420-0"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169192", "l": "PTP1B dephosphorylates GHR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63224", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 = 2-[12-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl]-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58057", "l": "hypotaurine + pyruvate => 2-sulfinoacetaldehyde + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57901", "l": "2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2 => adenosine in U6 snRNA + CO2 + formaldehyde + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41261", "l": "(E)-3-(indol-3-yl)acrylate + NH4(+) => L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805785", "l": "AKT phosphorylates PHF20 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13011", "l": "formate + H(+) + L-kynurenine => H2O + N-formyl-L-kynurenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36667", "l": "(15Z)-tetracosenoyl-CoA + sphinganine = CoA + H(+) + N-(15Z-tetracosenoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47537", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => isochenodeoxycholate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694583", "l": "ABHD4 hydrolyses NAPE (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23135", "l": "3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] <=> 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36300", "l": "(E)-caffeate + ATP + CoA => (E)-caffeoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25823", "l": "H2O + O2 + spermidine <=> 4-aminobutanal + H2O2 + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62041", "l": "H2O + N-(octanoyl)-sphing-4-enine-1-phosphate => N-octanoylsphing-4-enine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61071", "l": "acetyl-CoA + horhammericine <=> 19-O-acetylhorhammericine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46201", "l": "5alpha-androstane-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] => 5alpha-androstane-3beta,6alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034012", "l": "FAD-AMP lyase (cyclizing) activity"}, {"i": "RHEA:13729", "l": "FAD = AMP + H(+) + riboflavin cyclic-4',5'-phosphate"}, {"i": "EC:4.6.1.15", "l": "\"FAD-AMP lyase (cyclizing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781814", "l": "USP19 deubiquitinates RNF123 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033701", "l": "dTDP-galactose 6-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0032454", "l": "histone H3-methyl-lysine-9 demethylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602484", "l": "Activation of proMMP11 by FURIN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213244", "l": "Loading of antigenic peptides (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52734", "l": "adenosine 3',5'-bisphosphate + an 11-sulfojasmonate + H(+) => 3'-phosphoadenylyl sulfate + an 11-hydroxyjasmonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592362", "l": "Activation of proMMP7 by MMP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24622", "l": "H(+) + NADH + octanal => NAD(+) + octan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706354", "l": "Ubiquitination of FLT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66386", "l": "scalar-17(25)-en-19-ol => (2E,6E,10E,14E)-geranylfarnesol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24712", "l": "L-glutamate + UDP-beta-L-threo-pentopyranos-4-ulose => 2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850945", "l": "Casein kinase II phosphorylates PTEN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18646", "l": "2 putrescine => NH4(+) + sym-homospermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109339", "l": "Linoleoyl-CoA is converted to cis,cis-3,6- dodecadienoyl-CoA by three cycles of beta-oxidation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17541", "l": "an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2"}, {"i": "EC:1.1.3.7", "l": "\"Aryl-alcohol oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250986", "l": "botG HC:LC binds SYT1 and GT1b on the target cell surface (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936851", "l": "AHRR binds ARNT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001156", "l": "TFIIIC-class transcription factor complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050550", "l": "pinene synthase activity"}, {"i": "MetaCyc:4.2.3.14-RXN"}, {"i": "EC:4.2.3.14"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46575", "l": "2 H(+) + hexanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 5-hexenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58975", "l": "H2O + O2 + vanillin <=> 4-hydroxy-3-methoxybenzoate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62857", "l": "GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849085", "l": "ARHGAP35 binds RHOA:GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30049", "l": "chloroacetate + 2 H(+) + NADH => chloroacetaldehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37719", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59023", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O <=> (9Z,12Z)-octadecadienoate + di-(9Z,12Z)-octadecadienoylglycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578663", "l": "MSH3 variant:MSH2-defective DNA mismatch repair (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16259", "l": "alpha-D-glucose + alpha-D-glucose 1-phosphate => alpha,alpha-trehalose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610867", "l": "HCMV Binds Host Cell Receptor - Endocytic Pathway (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52016", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA = 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "68.074707754118222", "identifiers": [{"i": "GO:0008233", "l": "peptidase activity"}, {"i": "REACT:R-HSA-3000243", "l": "Unknown protease degrades CBLIF:Cbl to release Cbl (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14683", "l": "2-aminophenoxazin-3-one + AH2 + 2 H2O => 2 2-aminophenol + A + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173739", "l": "Spontaneous hydrolysis of C3 thioester (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382053", "l": "Translocation of PDGF from ER to Golgi (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2024100", "l": "GLCE epimerises GlcA to IdoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24797", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O = (S)-2-amino-6-oxoheptanedioate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102649", "l": "acetoacetyl-ACP synthase activity"}, {"i": "MetaCyc:RXN-15810"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191763", "l": "snRNP:Snurportin complex formation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103041", "l": "thiosulfate-thioredoxin sulfurtransferase activity"}, {"i": "MetaCyc:RXN0-6385"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805103", "l": "AURKA phosphorylates TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15093", "l": "2-oxoglutarate + L-tyrosine = 3-(4-hydroxyphenyl)pyruvate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0047224", "l": "acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14783", "l": "6-carboxyhexanoyl-CoA + AMP + diphosphate => ATP + CoA + heptanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612448", "l": "MXD4 gene expression is stimulated by ERBB4s80 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396029", "l": "Latent TGF-beta-3 binds integrins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983259", "l": "Kinesins move along microtubules consuming ATP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.118", "l": "\"Kallikrein 8\""}]}
{"type": "biolink:MolecularActivity", "ic": "80.155824608458104", "identifiers": [{"i": "GO:0036361", "l": "racemase activity, acting on amino acids and derivatives"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22081", "l": "H(+) + NADH + O2 + quinolin-2-ol => H2O + NAD(+) + quinoline-2,8-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051477", "l": "mannosylglycerate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65588", "l": "(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24155", "l": "adenosine 5'-phosphosulfate + ATP <=> 3'-phosphoadenylyl sulfate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44872", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18034", "l": "benzoate + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxybenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036373", "l": "L-fucose mutarotase activity"}, {"i": "RHEA:25580", "l": "alpha-L-fucose = beta-L-fucose"}, {"i": "EC:5.1.3.29", "l": "\"L-fucose mutarotase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27753", "l": "2'-deoxyinosine + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36089", "l": "1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18556", "l": "(2R,3S)-tartrate + NAD(+) <=> dihydroxyfumarate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211247", "l": "Cleavage of DNA by DFF40 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432172", "l": "Glycine and glutamate ligands bind GRIN1:GRIN2 NMDA receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950778", "l": "p-Y693-STAT4 dimerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70479", "l": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042605", "l": "peptide antigen binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217013", "l": "Phosphorylation of RAD51 by tyrosine kinase Abelson family protein members (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33835", "l": "H2O + N-hexacosanoyl-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + hexacosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928578", "l": "EPH receptors autophosphorylate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.139"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706344", "l": "FLT3 phosphorylates GRB10 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693356", "l": "CEMIP hydrolyses HA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390886", "l": "HRH4 binds Hist (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65793", "l": "fluometuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-[3-(trifluoromethyl)phenyl]-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432897", "l": "ILK interacts with beta-1 integrin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43809", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66250", "l": "AMP + H(+) + IC-asc-C9-CoA => CoA + IC-asc-C9-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24631", "l": "2 H2O + 3 NAD(+) + NH4(+) <=> 5 H(+) + 3 NADH + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56163", "l": "an archaeal dolichyl alpha-D-glucosyl phosphate + UDP-alpha-D-glucuronate <=> an archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58626", "l": "dodecanamide + glyoxylate => N-dodecanoyl-(2S)-hydroxyglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22338", "l": "L-methionine + N,N-dimethylglycine => glycine betaine + L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351913", "l": "Caspase-mediated cleavage of TJP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16660", "l": "H2O + inosine <=> D-ribose + hypoxanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30474", "l": "(2Z,6Z)-farnesyl diphosphate <=> (-)-endo-alpha-bergamotene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22972", "l": "butanal + CoA + NADP(+) = butanoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58802", "l": "5'-pApG-3' + H(+) => 3',3'-cGAMP + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032448", "l": "DNA hairpin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-532667", "l": "Removal of the second glucose by glucosidase II (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60941", "l": "(9Z)-hexadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => (9Z)-16-hydroxyhexadec-9-enoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034003", "l": "vetispiradiene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64575", "l": "isopentenyl diphosphate + neryl diphosphate <=> (2Z,6Z)-farnesyl diphosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4332236", "l": "CBL neddylates TGFBR2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939204", "l": "ESTG binds ESR1:chaperone complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33690", "l": "3'-N-debenzoyltaxol + benzoyl-CoA <=> CoA + H(+) + taxol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392530", "l": "p-S400-Cot phosphorylates NIK (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729283", "l": "Nucleoprotein is methylated by PRMT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63493", "l": "H(+) + menadione + NADPH => menadiol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39556", "l": "3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391935", "l": "DP1 receptor can bind PGD2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62126", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + GDP => a 2'-deoxyribonucleoside 5'-phosphate + GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15988", "l": "formate + NAD(+) <=> CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58367", "l": "a medium-chain primary fatty alcohol + NADP(+) <=> a medium-chain fatty aldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21860", "l": "3'-phosphoadenylyl sulfate + quercetin 3,3'-bissulfate = adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3',7-trissulfate"}, {"i": "EC:2.8.2.28", "l": "\"Quercetin-3,3'-bissulfate 7-sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39732", "l": "3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38993", "l": "1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+) => 1-dodecanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11265", "l": "H(+) + NADH + O2 => H2O2 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42357", "l": "(9Z)-tetradecenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(11Z)-hexadecenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163773", "l": "Phosphorylation of PF2K-Pase by PKA catalytic subunit (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59631", "l": "H2O + N(2)-(4-aminobutanoyl)-L-arginine <=> 4-aminobutanoate + L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1028821", "l": "Dimerization of Phospho IRF3 or phospho IRF7 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.28", "l": "\"Double-stranded uracil-DNA glycosylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32824", "l": "phosphate(in) => phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33755", "l": "H2O + N-hexadecanoyl-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75079", "l": "Formation of AT-AC C complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69152", "l": "Removal of remaining Flap (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869694", "l": "oxPL binds CD14 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33002", "l": "(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> (+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034522", "l": "cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382058", "l": "Nck binds to the active PDGF receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56626", "l": "2,5-dichlorocyclohexa-2,5-dien-1,4-diol + chloride + H(+) => 2,4,5-trichlorocyclohexa-2,5-dien-1-ol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50138", "l": "(9Z)-octadecenoate + ethanol + H(+) => ethyl (9Z)-octadecenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63465", "l": "(2E,6E,10E)-geranylgeraniol + UTP => (2E,6E,10E)-geranylgeranyl phosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5444523", "l": "Formation of MSH1:PMS2 Complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218821", "l": "PDK1 phosphorylates PKC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55021", "l": "5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O => 5,6-diaminouracil + D-ribose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70479", "l": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0008521", "l": "acetyl-CoA transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791177", "l": "Expression of KLHDC3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54132", "l": "a ribonucleoside 5'-diphosphate-alpha-D-glucose + D-glucose 6-phosphate = a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose 6-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605624", "l": "Beta-galactosidase hydrolyses GM1 to GM2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16141", "l": "2'-deoxymugineate + NAD(+) = 3''-deamino-3''-oxonicotianamine + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14825", "l": "(1R,5S)-carveol + NAD(+) = (S)-carvone + H(+) + NADH"}, {"i": "EC:1.1.1.275", "l": "\"(+)-trans-carveol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020274", "l": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507868", "l": "Aquaporins passively transport water into cells (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004059", "l": "aralkylamine N-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009488", "l": "IL34 binds CSF1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26395", "l": "2 (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial => all-trans-zeaxanthin + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876789", "l": "CARNMT1 methylates CARN to Anserine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018798", "l": "RHOV binds GTP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043515", "l": "kinetochore binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16931", "l": "2 CoA + 2 H(+) + N(2),N(5)-dibenzoyl-L-ornithine => 2 benzoyl-CoA + L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42402", "l": "L-histidyl-[protein] + lactose 6-phosphate(in) => lactose(out) + N(pros)-phospho-L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63670", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADPH => CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047199", "l": "phosphatidylcholine-dolichol O-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693061", "l": "STAMBP binds STAM (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160851", "l": "HAS1,2,3 mediate the polymerisation of HA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44298", "l": "4-hydroxy-5-methyl-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + hexadecanoyl-CoA + malonyl-CoA + methylmalonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018722", "l": "1-phenanthrol sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167014", "l": "pro-beta-NGF homodimer transits to the golgi apparatus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000109", "l": "CD320:TCII:Cbl dissociates into CD320 and TCII:Cbl (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48895", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O <=> L-threonyl-[protein] + N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14905", "l": "5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine"}, {"i": "EC:2.4.2.14", "l": "\"Amidophosphoribosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33310", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein] <=> (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052817", "l": "very long chain acyl-CoA hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12677", "l": "AH2 + Latia luciferin + 2 O2 = A + CO2 + formate + H(+) + H2O + hnu + oxidized Latia luciferin"}, {"i": "EC:1.14.99.21", "l": "\"Latia-luciferin monooxygenase (demethylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15739", "l": "5-valerolactone + H2O + NADP(+) => cyclopentanone + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193981", "l": "CYP21A2 oxidises 17HPROG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39807", "l": "octadecanoate(in) = octadecanoate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53058", "l": "H(+) + isowyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine => 4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45535", "l": "H2O + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39044", "l": "22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase] => docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.3.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043916", "l": "DNA-7-methylguanine glycosylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202325", "l": "Recruitment of Gads to LAT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380008", "l": "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618107", "l": "ATP binding to HSP90 triggers conformation change (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0016750", "l": "O-succinyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158164", "l": "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0033041", "l": "sweet taste receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879459", "l": "F-actin capping protein is a heterodimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948027", "l": "RNASEs bind bacterial phospholipids (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38167", "l": "hexadecan-1-ol + hexadecanoyl-CoA = CoA + hexadecanyl hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70592", "l": "PXLP-K259-GOT1 dimer deaminates L-Asp (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55319", "l": "3 H2O + hydrogen sulfide + 3 NAD(+) <=> 4 H(+) + 3 NADH + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.16", "l": "\"Geosmin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61552", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = gibberellin A12 aldehyde + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58293", "l": "25-substituted-cholesterol + beta-D-glucosyl-N-dodecanoylsphing-4E-enine => 25-substituted-cholesteryl beta-D-glucoside + N-dodecanoylsphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60105", "l": "3-(1H-indol-3-yl)propanoate + H(+) + oxidized [electron-transfer flavoprotein] => (E)-3-(indol-3-yl)acrylate + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605428", "l": "Expression of ESRRA (ERR1, ERRalpha) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40091", "l": "26-hydroxyhexacosanoate + NAD(+) = 26-oxohexacosanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022734", "l": "MECP2 binds FKBP5 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008083", "l": "growth factor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67080", "l": "a very long-chain fatty acid(in) + ATP + H2O = a very long-chain fatty acid(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879782", "l": "Expression of AVP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140620", "l": "DNA strand exchange inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55737", "l": "alpha-D-galacturonosyl-[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n) + UDP-beta-L-rhamnose => [(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936851", "l": "AHRR binds ARNT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60419", "l": "diglucosyl-enterobactin + H2O <=> H(+) + N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43226", "l": "(24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine => (24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9619355", "l": "CaMKK autophosphorylates in the cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928576", "l": "RHOA:GTP binds ROCK, activating it (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50489", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21994", "l": "CoA + H(+) + N(6)-acetyl-L-lysyl-[histone] => acetyl-CoA + L-lysyl-[histone]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33849", "l": "(4R)-hydroxysphinganine + tetracosanoate => H2O + N-tetracosanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202966", "l": "Caspase mediated cleavage of HIP-55 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12610", "l": "mercaptopurine + S-adenosyl-L-methionine => 6-methylthiopurine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964274", "l": "G alpha (12) binds BTK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418662", "l": "Src activation following P2Y purinoceptor activation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052609", "l": "4-ketotorulene 3-hydroxylase activity"}, {"i": "MetaCyc:RXN-8218"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19436", "l": "ATP + D-gluconate <=> 6-phospho-D-gluconate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40768", "l": "(20S)-ginsenoside R1 + H2O => (20S)-ginsenoside Rg1 + D-xylose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47600", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate = CMP + ganglioside GM4 (d18:1(4E)) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13892", "l": "FAD + H2O <=> AMP + FMN + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374298", "l": "Opioid receptors bind opioid peptides (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026544", "l": "Non-enzymatic hydrolysis hydrolyses 13(S),14(S)-epoxy-DHA to 7-epi-MaR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2263495", "l": "Defective GNS does not hydrolyse 6-sulfate from GlcNAc6S (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39098", "l": "(3S)-hydroxydecanedioyl-CoA + NAD(+) <=> 3-oxodecanedioyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4411373", "l": "NLK translocates to nucleus (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975122", "l": "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635667", "l": "esxG:esxH binds HGS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218820", "l": "Src kinases phosphorylate VAV (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56506", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001665", "l": "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65635", "l": "a sphingoid base + tetracosanoyl-CoA <=> an N-tetracosanoyl-sphingoid base + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41002", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-tetradecanoyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4539779", "l": "Collagen type IV binds integrin alpha10beta1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24225", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP(+) => 4-methylcatechol + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706393", "l": "RHOBTB3 binds ATP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12525", "l": "L-pipecolate + NADP(+) => Delta(1)-piperideine-2-carboxylate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102985", "l": "delta12-fatty-acid desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46850", "l": "5alpha-cholest-8-en-3-one + CO2 + NADPH => 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24876", "l": "H2O + O-phospho-D-serine <=> D-serine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62012", "l": "cytidine(2499) in 23S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(2499) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604732", "l": "Autocatalytic activation of proMMP13 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.n2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029451", "l": "Activation of RAC1 by VAV (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56029", "l": "3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) => 3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40350", "l": "3-oxotetradecanedioyl-CoA + CoA <=> acetyl-CoA + dodecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47565", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GA2 (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54257", "l": "2-oxoglutarate + L-histidyl-[protein] + O2 => (3S)-3-hydroxy-L-histidyl-[protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638007", "l": "RP2 activates the GTPase activity of ARL3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41864", "l": "(2E)-decenoyl-[ACP] + H(+) + NADPH = decanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51414", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110319", "l": "Elongation by POLH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55833", "l": "cortisone + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxycortisone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44609", "l": "3-(all-trans-nonaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-nonaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134821", "l": "DNA-PK binds microbial dsDNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43618", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate => [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58856", "l": "(6E)-8-hydroxygeraniol + NAD(+) = (6E)-8-oxogeraniol + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51683", "l": "(2E,6E)-farnesol + CTP <=> (2E,6E)-farnesyl phosphate + CDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13516", "l": "(S)-dihydroorotate + NAD(+) <=> H(+) + NADH + orotate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56474", "l": "(5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696605", "l": "USP12, USP26 deubiquitinate AR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669854", "l": "KIT binds type II TKIs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389491", "l": "Two NPFF receptors can bind neuropeptide FF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50288", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664567", "l": "ERBB2 KD mutants heterodimerize (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44518", "l": "(9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+) => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380930", "l": "Phosphorylated AMPK binds AMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685011", "l": "ATR activation at DNA DSBs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849826", "l": "ST14 hydrolyzes and activates KLK5 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201515", "l": "Active ALK recruits PI3K (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24804", "l": "2-oxoglutarate + L-isoleucine <=> (S)-3-methyl-2-oxopentanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871226", "l": "RET binds GFRA1,GFRA2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24480", "l": "a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol"}, {"i": "EC:3.2.1.149", "l": "\"Beta-primeverosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65164", "l": "benzoyl-CoA + hexan-3-ol = CoA + hexan-3-yl benzoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416698", "l": "SEMA5A binds to PLXNB3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31377", "l": "1H-pyrrole + CO2 => H(+) + pyrrole-2-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19518", "l": "H2O + N,N-dimethylformamide => dimethylamine + formate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65147", "l": "2-oxoglutarate + berkeleyone A + O2 <=> CO2 + H2O + preaustinoid A + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44524", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-glycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784861", "l": "HSPG binds LPL dimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52638", "l": "a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate => 2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009227", "l": "IL20 binds to IL22RA1:JAK1:IL20RB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685011", "l": "ATR activation at DNA DSBs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39291", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12550", "l": "2-cis-(+)-abscisic aldehyde + H(+) + NADH => 2-cis,4-trans-xanthoxin + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004103", "l": "choline kinase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033767", "l": "4-hydroxyacetophenone monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111966", "l": "GRK2 binds CALM1:4Ca2+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989759", "l": "Expression of G0S2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936381", "l": "OTUD5 deubiquitinates TRAF3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39232", "l": "3-oxo-triacontanoyl-CoA + H(+) + NADPH => (3R)-hydroxytriacontanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031881", "l": "DPAn-3 resolvins translocate from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404134", "l": "RBP4:atROL binds TTR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.12", "l": "\"Xanthan lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9607301", "l": "Active FLT3:GRB2 binds SOS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12468", "l": "avenacoside A + H2O = 26-desgluco-avenacoside A + D-glucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080074", "l": "spermidine:caffeoyl CoA N-acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43652", "l": "decanoyl-CoA + H(+) + malonyl-[ACP] = 3-oxododecanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15398", "l": "dichloromethane + H2O => 2 chloride + formaldehyde + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60386", "l": "N-(2,3-dihydroxybenzoyl)-L-serine trimer => enterobactin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39268", "l": "(15Z)-3-oxotetracosenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(15Z)-tetracosenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40236", "l": "coenzyme B + coenzyme M + fumarate => coenzyme M-coenzyme B heterodisulfide + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40894", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O <=> H(+) + hexadecanoate + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036312", "l": "phosphatidylinositol 3-kinase regulatory subunit binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38355", "l": "(R)-3-phenyllactoyl-CoA = (E)-cinnamoyl-CoA + H2O"}, {"i": "EC:4.2.1.175", "l": "\"(R)-3-(aryl)lactoyl-CoA dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166038", "l": "GPI-bound CD14 binds LPS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42783", "l": "adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35823", "l": "5,6,7,8-tetrahydromethanopterin + NAD(+) = 7,8-dihydromethanopterin + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061596", "l": "3-sulfolactaldehyde reductase activity"}, {"i": "RHEA:40511", "l": "2,3-dihydroxypropane-1-sulfonate + NAD(+) = 3-sulfolactaldehyde + H(+) + NADH"}, {"i": "EC:1.1.1.373", "l": "\"Sulfolactaldehyde 3-reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936985", "l": "Activated TLR4:TICAM1 recruits TRAF6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443831", "l": "14-3-3-zeta binds Raf1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8864577", "l": "TFAP2C translocates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375138", "l": "CDO binds BOC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57936", "l": "H2O + isopyridoxal + NAD(+) = 5-pyridoxate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.102", "l": "\"Isopyridoxal dehydrogenase (5-pyridoxate-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52396", "l": "4-O-phospho-D-threonate + NAD(+) = CO2 + dihydroxyacetone phosphate + NADH"}, {"i": "EC:1.1.1.408", "l": "\"4-phospho-D-threonate 3-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.64", "l": "\"Peptidase K\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53848", "l": "NAD(+) + taurocholate = 7-oxo-taurodeoxycholate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236970", "l": "Proteasomal clevage of exogenous antigen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60881", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O => a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42762", "l": "(2R)-3-phosphoglycerate + 2 H(+) + NADH => D-glyceraldehyde 3-phosphate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43517", "l": "2-carboxy-5-formylfuran + H2O => 2-carboxy-5-(dihydroxymethyl)furan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.n2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51748", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A = 4-amino-4-deoxy-beta-L-arabinopyranosyl-lipid A + di-trans,octa-cis-undecaprenyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0005283", "l": "amino acid:sodium symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-688136", "l": "TNFAIP3 (A20) deubiquitinates RIP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.108"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19773", "l": "NADP(+) + sn-glycerol 3-phosphate = D-glyceraldehyde 3-phosphate + H(+) + NADPH"}, {"i": "EC:1.1.1.177", "l": "\"Glycerol-3-phosphate 1-dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38857", "l": "2 [Fe(III)-cytochrome b5] + a (R)-2-hydroxy fatty acid + H2O => 2 [Fe(II)-cytochrome b5] + a 1,2-saturated fatty acid + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46275", "l": "2 [Fe(II)-cytochrome b5] + an N-acyl-(4R)-4-hydroxysphinganine + 2 H(+) + O2 <=> (4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55934", "l": "AMP + H(+) + L-threonyl-[protein] => 3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16037", "l": "phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + thymine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16231", "l": "a CDP-1,2-diacyl-sn-glycerol + diphosphate => a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36776", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose => alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140571", "l": "transmembrane ascorbate ferrireductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941895", "l": "Formation of CDK4/6:CCND complexes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-438019", "l": "activated chicken MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18104", "l": "cis-1,2-dihydro-3-ethylcatechol + NAD(+) <=> 3-ethylcatechol + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9641111", "l": "Parkin transfers Ub to misfolded proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428534", "l": "Recruitment of Profilin by Ena/VASP proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42565", "l": "uridine(38/39) in tRNA => pseudouridine(38/39) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19509", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 2 H(+) + L-erythro-biopterin + 2 NADPH"}, {"i": "EC:1.5.1.33", "l": "\"Pteridine reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798748", "l": "Exocytosis of secretory granule lumen proteins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61883", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-12-hydroperoxy-20-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41991", "l": "3beta-hydroxy-5alpha-pregnane-20-one + NAD(+) <=> 5alpha-pregnane-3,20-dione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62985", "l": "H2O + hexadecanamide => hexadecanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63149", "l": "H2O + N-(9Z-octadecenoyl)-taurine => (9Z)-octadecenoate + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60353", "l": "2-heptyl-3-hydroxy-4(1H)-quinolone + O2 => CO + H(+) + N-octanoylanthranilate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031014", "l": "troponin T binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40534", "l": "2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + neopikromycin + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13345", "l": "(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}, {"i": "EC:2.5.1.58", "l": "\"Protein farnesyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42144", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoyl-(4R)-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172433", "l": "Collagen type XIX degradation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177930", "l": "GAB1 phosphorylation by EGFR kinase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944247", "l": "Association of procollagen type VI (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031927", "l": "pyridoxamine transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034186", "l": "apolipoprotein A-I binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3321805", "l": "NSL acetylates histone H4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.n3", "l": "\"Dictyostelium lysozyme A\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43634", "l": "an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe) => an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972978", "l": "POU5F1 (OCT4), SOX2, NANOG bind the ZIC3 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14053", "l": "D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate"}, {"i": "EC:2.5.1.55", "l": "\"3-deoxy-8-phosphooctulonate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.-", "l": "\"Metallocarboxypeptidases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453342", "l": "PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48695", "l": "1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O <=> H(+) + octanoate + octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12273", "l": "H(+) + L-dopa => CO2 + dopamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11581", "l": "a CDP-1,2-diacyl-sn-glycerol + myo-inositol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9625482", "l": "PTK2 binds activated EGFR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168337", "l": "Docking and transport of the RNP:Karyopherin complex through the nuclear pore (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176298", "l": "Activation of claspin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42418", "l": "(S)-1-pyrroline-5-carboxylate + a ubiquinol + H(+) => a ubiquinone + L-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202702", "l": "CD177 binds PECAM-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674385", "l": "p-T,Y MAPKs dimerize (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5615668", "l": "AKR1C3 reduces atRAL to atROL (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852317", "l": "PLK1 phosphorylates GTSE1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449058", "l": "Interleukin-1 family are secreted (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204850", "l": "Interaction of Tie2 and Dok-2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928578", "l": "EPH receptors autophosphorylate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0050463", "l": "nitrate reductase [NAD(P)H] activity"}, {"i": "EC:1.7.1.2", "l": "\"Nitrate reductase (NAD(P)H)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36387", "l": "carbamoyl adenylate + kanamycin A = 6''-O-carbamoylkanamycin A + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033763", "l": "proline 3-hydroxylase activity"}, {"i": "RHEA:20265", "l": "2-oxoglutarate + L-proline + O2 = cis-3-hydroxy-L-proline + CO2 + succinate"}, {"i": "EC:1.14.11.28", "l": "\"Proline 3-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12246", "l": "(6S)-5,6,7,8-tetrahydrofolate + dTMP + FAD + H(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23986", "l": "cholesta-5,7-dien-3beta-ol + H(+) + NADPH => cholesterol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222006", "l": "STK11 (LKB1) phosphorylates NUAK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018497", "l": "1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2002460", "l": "P4HB binds Collagen chains (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39615", "l": "(3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA = (2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66505", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5683593", "l": "ATG7:ATG3:LC3 dissociates (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61636", "l": "ATP + CoA + isophthalate = AMP + diphosphate + isophthalyl-CoA"}, {"i": "EC:6.2.1.58", "l": "\"Isophthalate--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47159", "l": "7alpha,25-dihydroxycholesterol + NAD(+) <=> 7alpha,25-dihydroxy-4-cholesten-3-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15899", "l": "4-aminobutanoate + acetate => 4-acetamidobutanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612996", "l": "NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34597", "l": "3-dehydro-15-methylhexadecasphinganine + CO2 + CoA => H(+) + isopentadecanoyl-CoA + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1964496", "l": "STING binds TRIM32 or TRIM56  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33359", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20532", "l": "2-cis-(+)-abscisic aldehyde + H2O + O2 <=> 2-cis-(+)-abscisate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.154", "l": "\"Fructan beta-(2,6)-fructosidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140383", "l": "4-hydroxytryptamine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158925", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-9635452", "l": "Pks5 transforms LFCA adenylate ester to mycocerosyl (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112042", "l": "Opioid binds MOR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878054", "l": "HIPK2 phosphorylates RUNX1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6786650", "l": "DDHD1,2 hydrolyse PA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55752", "l": "2 CO2 + coenzyme B + coenzyme M + 2 reduced [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B heterodisulfide + 2 formate + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.8.98.6", "l": "\"Formate:CoB-CoM heterodisulfide,ferredoxin reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983983", "l": "p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201603", "l": "Caspase-mediated cleavage of PKC theta (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868118", "l": "MAPK12 phosphorylates PTPN3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59031", "l": "(Z)-24-ethylidenelophenol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33758", "l": "H2O + N-hexadecanoyl-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55829", "l": "cortisol + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63945", "l": "a fatty acyl-CoA + sphinga-4E,14Z-dienine => an N-acyl-sphinga-4E,14Z-dienine + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27305", "l": "7-chloro-L-tryptophan + O2 <=> 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45904", "l": "devancoaminyl-vancomycin + dTDP-beta-L-vancosamine = dTDP + epivancomycin + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52338", "l": "a long-chain fatty acyl-AMP + diphosphate => a long-chain fatty acid + ATP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43386", "l": "ADP + H(+) + N(omega)-phospho-L-arginyl-[protein] => ATP + L-arginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984963", "l": "EBI3 gene transcription and translation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49636", "l": "H2O + methylglyoxal + O2 = H(+) + H2O2 + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016851", "l": "magnesium chelatase activity"}, {"i": "KEGG.REACTION:R03877"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45085", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47823", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-triphosphate + NADPH + O2 <=> 9-ribosyl-trans-zeatin 5'-triphosphate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375151", "l": "Interaction of NCAM1 with collagens (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14715", "l": "5-dehydro-D-fructose + AH2 => A + keto-L-sorbose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54258", "l": "(3S)-3-hydroxy-L-histidyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-histidyl-[protein] + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072346", "l": "cADPR-sensitive calcium-release channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1006143", "l": "CD46 binds C3b (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62130", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + dGDP => a 2'-deoxyribonucleoside 5'-phosphate + dGTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48601", "l": "[protein-PII]-uridylyl-L-tyrosine + H2O => [protein-PII]-L-tyrosine + H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944233", "l": "Association of procollagen type XIX (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48773", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a => 3-deacetyl-3-vinylbacteriochlorophyllide a + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21012", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine = 4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP"}, {"i": "EC:2.4.1.70", "l": "\"Poly(ribitol-phosphate) alpha-N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40377", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240957", "l": "Formation of PRC2-EZH2 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30296", "l": "GTP + pyruvate => GDP + H(+) + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26489", "l": "H(+) + O-phospho-L-serine + sulfite <=> L-cysteate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18642", "l": "a menaquinone + H2 => a menaquinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44252", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50381", "l": "3 H(+) + 3 malonyl-CoA => 1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867041", "l": "EGFR phosphorylates EPS15 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790029", "l": "Expression of PTGS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935731", "l": "ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29917", "l": "alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP => L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.74", "l": "\"Cutinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30366", "l": "fumonisin B1 + 2 H2O <=> (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 H(+) + 2 tricarballylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33978", "l": "DIMBOA beta-D-glucoside + H2O <=> D-glucose + DIMBOA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368087", "l": "RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55228", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47129", "l": "ATP + CoA + deoxycholate => AMP + deoxycholoyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9639286", "l": "RRAGC,D exchanges GTP for GDP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33102", "l": "acetyl-CoA + spermine <=> CoA + H(+) + N(1)-acetylspermine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27866", "l": "(2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate + H2O = (R)-glycerate + alpha-D-mannose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68960", "l": "DNA polymerase epsilon binds at the origin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70899", "l": "histidine => urocanate + NH4+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51091", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35610", "l": "acetoin + NADP(+) <=> diacetyl + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23123", "l": "a dipeptide(out) + ATP + H2O <=> a dipeptide(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1170539", "l": "Prolactin receptor is internalized (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29533", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202127", "l": "eNOS synthesizes NO (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264435", "l": "Dissociation of the COP1-p53 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60339", "l": "N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849900", "l": "SALMs1-3 bind each other in cis interactions (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31639", "l": "mycinamicin III + S-adenosyl-L-methionine = H(+) + mycinamicin IV + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.237", "l": "\"Mycinamicin III 3''-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.8", "l": "\"Cystathionine beta-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052774", "l": "glucosyl-N-acetylglucosamine glucosaminidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602454", "l": "proMMP9 binds TIMP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876446", "l": "p-ULK1 phosphorylates DENND3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782943", "l": "UV-DDB ubiquitinates XPC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40075", "l": "6-amino-6-deoxyfutalosine + H(+) + H2O = futalosine + NH4(+)"}, {"i": "EC:3.5.4.40", "l": "\"Aminodeoxyfutalosine deaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56446", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate => 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451649", "l": "TPL2 phosphorylates MEK1, SEK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191830", "l": "snRNP nuclear import and release (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047079", "l": "deoxyuridine 1'-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905574", "l": "ganglioside GM2 binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001019", "l": "plastid promoter transcription regulatory region sequence-specific DNA binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018603", "l": "nitrobenzene 1,2-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29335", "l": "H2O + L-alanyl-L-glutamate = L-alanine + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60746", "l": "CoA + pyrethrin I => (1R,3R)-chrysanthemoyl-CoA + (Z,S)-pyrethrolone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033757", "l": "glucoside 3-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168184", "l": "Activated TAK1 mediates phosphorylation of the IKK Complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61559", "l": "gibberellin A12 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> gibberellin A15 + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030621", "l": "U4 snRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36109", "l": "O-methyl gibberellin A4 + S-adenosyl-L-homocysteine => gibberellin A4 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50746", "l": "2 aminomethylphosphonate + 2 glyoxylate + 2 H(+) => 2 glyphosate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41172", "l": "1-acyl-2-hexadecenoyl-sn-glycero-3-phosphate + H2O => 2-hexadecenoyl-sn-glycero-3-phosphate + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5229132", "l": "AP4 binds APP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9005995", "l": "MECP2 binds the SIN3A co-repressor complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015057", "l": "thrombin-activated receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66169", "l": "[protein]-with a C-terminal TM segment(out) + ATP + H2O => [protein]-with a C-terminal TM segment(in) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194793", "l": "botC LC cleaves target cell SNAP25 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948703", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-481009", "l": "Exocytosis of platelet dense granule content (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396007", "l": "IRF3 is phosphorylated by TBK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32154", "l": "9alpha-copalyl diphosphate <=> (12E)-9alpha-labda-8(17),12,14-triene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13057", "l": "an N-acylneuraminate 9-phosphate + H2O = an N-acylneuraminate + phosphate"}, {"i": "EC:3.1.3.29", "l": "\"N-acylneuraminate-9-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26083", "l": "(Z)-gamma-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56713", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] => H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.40"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12764", "l": "precorrin-3B + S-adenosyl-L-methionine <=> 3 H(+) + precorrin-4 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26129", "l": "(+)-copalyl diphosphate => diphosphate + isopimara-7,15-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0043855", "l": "cyclic nucleotide-gated ion channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56660", "l": "7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) = 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}, {"i": "RHEA:56664", "l": "7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD(+) = 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}, {"i": "EC:1.3.1.115", "l": "\"3-oxocholoyl-CoA 4-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64081", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O => 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48678", "l": "20-hydroxy-6-trans-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-trans-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047140", "l": "glutathione-CoA-glutathione transhydrogenase activity"}, {"i": "RHEA:13125", "l": "CoA + glutathione disulfide = CoA-glutathione + glutathione"}, {"i": "EC:1.8.4.3", "l": "\"Glutathione--CoA-glutathione transhydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8943279", "l": "GGT dimers hydrolyse GSH (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19222", "l": "2 formaldehyde + H2O => formate + H(+) + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39977", "l": "2-oxobutanoate + NH4(+) => 2-iminobutanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15199", "l": "an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine => a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167282", "l": "2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47310", "l": "6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46804", "l": "a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine = a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.317", "l": "\"Sphingolipid C(9)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035169", "l": "Expression of CETP regulated by NR1H2 or NR1H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12207", "l": "dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> 3alpha-hydroxy-3,5-dihydromonacolin L carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674095", "l": "PDGFRs bind type II TKI (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22670", "l": "H(+) + lipid A disaccharide (E. coli) + UDP => 2-N,3-O-bis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-452097", "l": "Recruited STAT5 is phosphorylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15850", "l": "2 [Fe(III)cytochrome c] + L-ascorbate => 2 [Fe(II)cytochrome c] + 2 H(+) + L-dehydroascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62722", "l": "betaenone B + 3 H2O + 3 NADP(+) => 3 H(+) + 3 NADPH + 3 O2 + probetaenone I"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65179", "l": "A + protoaustinoid A <=> AH2 + protoaustinoid B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77081", "l": "Formation of the CE:GMP intermediate complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19808", "l": "a purine D-ribonucleoside + phosphate <=> a purine nucleobase + alpha-D-ribose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30799", "l": "(3S)-3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1183032", "l": "Expression of GLUT4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33797", "l": "alpha-D-glucose + beta-D-fructose => H2O + sucrose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664867", "l": "NBR1 binds MAP1LC3B (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2731141", "l": "Syndecan-1 binds fibronectin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19224", "l": "2 formaldehyde + H2O <=> formate + H(+) + methanol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001073", "l": "transcription antitermination factor activity, DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8980691", "l": "RHOA GEFs activate RHOA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102901", "l": "isopimaradienol hydroxylase activity"}, {"i": "MetaCyc:RXN-8536"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9038658", "l": "RHD gene produces PALM-C-Rhesus D protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102806", "l": "4-coumaroyl-CoA:cyanidin-3,5-diglucoside-6''-O-acyltransferase activity"}, {"i": "MetaCyc:RXN-8170"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.184"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69142", "l": "Recruitment of Dna2 endonuclease (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39915", "l": "1-O-alkyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983285", "l": "RAD51B binds RAD51C (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228992", "l": "ROCK1,ROCK2 are activated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9749197", "l": "ORC1 binds to H4K20me2 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "77.690207805941611", "identifiers": [{"i": "GO:0004029", "l": "aldehyde dehydrogenase (NAD+) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53039", "l": "4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50578", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72691", "l": "Formation of the 43S pre-initiation complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9619376", "l": "CAMK1 binds calmodulin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22855", "l": "L-serine + pyruvate <=> 3-hydroxypyruvate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8934465", "l": "SHC1 binds PTPN12 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14153", "l": "17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP-N-acetyl-alpha-D-glucosamine = 17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucosiduronate + H(+) + UDP"}, {"i": "EC:2.4.1.39", "l": "\"Steroid N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31521", "l": "3-methyl-2-butenal + 4'-apo-beta-carotenal => O2 + torulene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21930", "l": "2,3-dioxo-L-gulonate + H(+) + NADPH => 3-dehydro-L-gulonate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088134", "l": "PLK1 phosphorylates FOXM1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5656070", "l": "FGFBPs bind FGFs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606807", "l": "Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944227", "l": "Association of procollagen type XXII (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052812", "l": "phosphatidylinositol-3,4-bisphosphate 5-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10287", "l": "L-leucine <=> (3R)-beta-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41208", "l": "1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31913", "l": "1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate => beta-D-fructose 1,6-bisphosphate + methylglyoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.2.2", "l": "\"Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56871", "l": "(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA <=> (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55179", "l": "2-oxoglutarate + butanoyl-CoA + O2 <=> 2-hydroxybutanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671737", "l": "p-T774-PKN1 binds CDC25C (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "73.946956196949927", "identifiers": [{"i": "GO:0140677", "l": "molecular function activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047941", "l": "glucuronolactone reductase activity"}, {"i": "RHEA:18925", "l": "L-gulono-1,4-lactone + NADP(+) = D-glucurono-3,6-lactone + H(+) + NADPH"}, {"i": "EC:1.1.1.20", "l": "\"Glucuronolactone reductase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052820", "l": "DNA-1,N6-ethenoadenine N-glycosylase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033908", "l": "beta-L-rhamnosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106360", "l": "2-hydroxy-3-methylhexadecanoyl-CoA lyase activity"}, {"i": "RHEA:25379", "l": "2-hydroxy-3-methylhexadecanoyl-CoA = 2-methylpentadecanal + formyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66861", "l": "dimethylallyl diphosphate + 4 isopentenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55983", "l": "a 1,2-saturated acyl-CoA + an acyl-CoA + H2O <=> an (R)-2-alkyl-3-oxoalkanoate + 2 CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47509", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADH => isolithocholate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66848", "l": "2 Cu(2+) + NADH = 2 Cu(+) + H(+) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247847", "l": "WLS is endocytosed to the early endosome (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32949", "l": "a 1,2-diacyl-sn-glycerol + CoA => a 2-acylglycerol + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42250", "l": "3-oxohexanoyl-[ACP] + CO2 + CoA => butanoyl-CoA + H(+) + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64284", "l": "2-phenylethylamine + pyruvate = 2-phenylacetaldehyde + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25199", "l": "5-amino-6-(D-ribitylamino)uracil + phosphate => 5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33591", "l": "sphinganine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047394", "l": "glycerophosphoinositol inositolphosphodiesterase activity"}, {"i": "RHEA:14033", "l": "H2O + sn-glycero-3-phospho-1D-myo-inositol = 1D-myo-inositol 1-phosphate + glycerol + H(+)"}, {"i": "EC:3.1.4.43", "l": "\"Glycerophosphoinositol inositolphosphodiesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20578", "l": "3-hydroxyaminophenol => aminohydroquinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29858", "l": "H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine <=> D-alanine + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55654", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106237", "l": "arachidonate 12(R)-lipoxygenase activity"}, {"i": "RHEA:41336", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44358", "l": "methyl nogalonate => nogalaviketone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.24", "l": "\"Aminobenzoate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668395", "l": "CHMP7 binds CC2D1B (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166387", "l": "The FA anion diffuses away laterally from UCP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29148", "l": "2 H(+)(in) + nitrate + ubiquinol-8 => 2 H(+)(out) + H2O + nitrite + ubiquinone-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37381", "l": "1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710106", "l": "ELANE cleaves GSDMD (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56413", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-ditetradecanoyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14401", "l": "chlordecone alcohol + NADP(+) = chlordecone + H(+) + NADPH"}, {"i": "EC:1.1.1.225", "l": "\"Chlordecone reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13517", "l": "ATP + dTMP = ADP + dTDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40035", "l": "ATP + L-glutamate + N-acetyl-L-aspartate = ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate"}, {"i": "EC:6.3.2.41", "l": "\"N-acetylaspartylglutamate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549322", "l": "OCT1 transports organic cations out of hepatic cells (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38324", "l": "2 1-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50254", "l": "a 3-oxoacyl-CoA + CO2 + CoA => an acyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14150", "l": "luteolin 7-O-beta-D-glucuronide + UDP-alpha-D-glucuronate => H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001531", "l": "interleukin-21 receptor binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106389", "l": "ecdysteroid 22-kinase activity"}, {"i": "MetaCyc:RXN-14755"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036070", "l": "Defective GUSB does not hydrolyse CS/HS precursor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176700", "l": "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391936", "l": "EP1 receptor can bind PGE2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24730", "l": "anthranilate + H(+) = aniline + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53751", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose <=> a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39002", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O <=> a 1-acyl-sn-glycero-3-phosphate + H(+) + L-serine"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0035400", "l": "histone tyrosine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941701", "l": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25419", "l": "AH2 + O2 + octadecanoyl-CoA <=> (9Z)-octadecenoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854981", "l": "SHC1 in the RET complex is phosphorylated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22958", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 [Fe(III)-cytochrome b5] + 2 H2O => 1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848713", "l": "PTK6 binds BCAR1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14270", "l": "2 a quinone + H(+) + NADPH => 2 a 1,4-benzosemiquinone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19182", "l": "a very-long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56798", "l": "adenosylcob(III)alamin + apo-[corrinoid adenosyltransferase] + triphosphate => [corrinoid adenosyltransferase]-cob(I)alamin + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029451", "l": "Activation of RAC1 by VAV (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65563", "l": "2-oxoglutarate + L-kynurenine <=> H2O + kynurenate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103075", "l": "indole-3-pyruvate monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15116", "l": "5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O <=> 5alpha-cholestane-3beta,5,6beta-triol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57758", "l": "C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+) => 2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198513", "l": "Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57375", "l": "H2O + NADPH <=> (6S)-NADPHX"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050179", "l": "phenylserine aldolase activity"}, {"i": "RHEA:21712", "l": "L-threo-3-phenylserine = benzaldehyde + glycine"}, {"i": "EC:4.1.2.26", "l": "\"Phenylserine aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424484", "l": "Phosphorylation of BTK by p-SYK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592314", "l": "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607023", "l": "factor IXa associates with cell membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31599", "l": "FMNH2 + NADH + O2 + thymine = (Z)-2-methylureidoacrylate + FMN + H(+) + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990984", "l": "tRNA demethylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52892", "l": "H2O + NADP(+) + nitrosobenzene = H(+) + NADPH + nitrobenzene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-984733", "l": "Kinesin-3 is a dimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30663", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = hapalindole H"}, {"i": "EC:5.5.1.31", "l": "\"Hapalindole H synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26452", "l": "H(+) + NADPH + succinyl-CoA => CoA + NADP(+) + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35415", "l": "an anthocyanidin 3-O-beta-D-sambubioside + UDP-alpha-D-glucose = an anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside + H(+) + UDP"}, {"i": "EC:2.4.1.295", "l": "\"Anthocyanin 3-O-sambubioside 5-O-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2203516", "l": "Alpha-1-Microglobulin is cleaved (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-376122", "l": "DSCAM/DSCAML1 homodimerization (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55364", "l": "(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + 6 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41906", "l": "(3R)-hydroxyhexadecanoyl-[ACP] + NADP(+) => 3-oxohexadecanoyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990606", "l": "membrane scission GTPase motor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592371", "l": "Initial activation of proMMP3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13973", "l": "diphosphate + H(+)(in) + H2O = 2 H(+)(out) + 2 phosphate"}, {"i": "EC:7.1.3.1", "l": "\"H(+)-exporting diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "ic": "78.819800280251172", "identifiers": [{"i": "GO:0016668", "l": "oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"}, {"i": "EC:1.8.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157100", "l": "NOTCH3 binds JAG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955712", "l": "SVBP:VASH1,VASH2 hydrolyzes the terminal L-Tyr residue from alphaY-beta tubulin dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18343", "l": "D-xylonate + H(+) => D-xylono-1,4-lactone + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20146", "l": "2-(3-amino-3-carboxypropyl)-L-histidine + S-adenosyl-L-methionine => 2-[3-carboxy-3-(methylammonio)propyl]-L-histidine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17600", "l": "2 [Fe(III)cytochrome c] + D-mannitol <=> 2 [Fe(II)cytochrome c] + D-fructose + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65558", "l": "an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc => globoside GalGb4Cer + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675417", "l": "PEBP1 binds activated RAF1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034554", "l": "3,3',5-tribromobisphenol A reductive dehalogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209738", "l": "VD3 binds GC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36023", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22660", "l": "a fatty acid + ATP + holo-[ACP] = a fatty acyl-[ACP] + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16725", "l": "a phosphatidylglycerol phosphate + H2O = a phosphatidylglycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31236", "l": "(4S)-4-hydroxy-L-glutamate + 2-oxoglutarate => (4R)-4-hydroxy-2-oxoglutarate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20822", "l": "choline + H(+) + sulfate => choline sulfate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37957", "l": "(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17314", "l": "ATP + L-histidine + tRNA(His) => AMP + diphosphate + H(+) + L-histidyl-tRNA(His)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655348", "l": "Activated FGFR4 mutants:p-FRS2 binds GRB2-SOS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43107", "l": "AH2 + N-acyleicosasphinganine + O2 <=> A + 2 H2O + N-acyleicosasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013567", "l": "HES1 gene expression is stimulated by NOTCH3 and STAT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16757", "l": "NADP(+) + trypanothione = H(+) + NADPH + trypanothione disulfide"}, {"i": "EC:1.8.1.12", "l": "\"Trypanothione-disulfide reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62474", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-nonadioyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31648", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O => 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67030", "l": "(glutathione)4[2Fe(III)-2S] cluster(out) + ADP + H(+) + phosphate => (glutathione)4[2Fe(III)-2S] cluster(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54642", "l": "(12E)-labda-8(17),12,14-triene + diphosphate => (+)-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211247", "l": "Cleavage of DNA by DFF40 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28019", "l": "enterobactin + 3 H2O => 2 H(+) + 3 N-(2,3-dihydroxybenzoyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "78.423603998002051", "identifiers": [{"i": "GO:0140104", "l": "molecular carrier activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63108", "l": "16-hydroxy-ilicicolin A epoxide = ascofuranol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694462", "l": "ABHD6,12 hydrolyse 3AG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167077", "l": "Recruitment of elongation factors to form HIV-1 elongation complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645481", "l": "TIFA oligomerization (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38422", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O <=> 1,3-di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9668395", "l": "CHMP7 binds CC2D1B (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35171", "l": "H(+)(out) + novobiocin(in) = H(+)(in) + novobiocin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20542", "l": "H(+) + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2 => 2 H2O + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59508", "l": "fumarate + L-cysteinyl-[protein] = S-(2-succinyl)-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52587", "l": "chenodeoxycholoyl-CoA + NAD(+) <=> 7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664879", "l": "ATM:PEX5 binds ATM (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45422", "l": "a fatty acid + H(+) + N-acyl-sn-glycero-3-phosphoethanolamine => H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029468", "l": "Conversion of PA into DAG by PAP-1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20875", "l": "(20S)-ginsenoside Rd + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rb1 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47549", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oate => 3-oxochola-4,6-dien-24-oate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018537", "l": "coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59560", "l": "H2O + N,N',N''-triacetylchitotriono-1,5-lactone = H(+) + N,N',N''-triacetylchitotrionate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23815", "l": "(+)-neomenthol + NADP(+) <=> (1R,4S)-menthone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71050", "l": "Trimerization of the FASL:FAS receptor complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.18"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54843", "l": "H(+) + NADPH + O2 + octan-3-one <=> H2O + NADP(+) + pentyl propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46963", "l": "butanoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> (2E)-butenoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52029", "l": "a jasmonyl-L-amino acid + H2O => a jasmonate + an L-alpha-amino acid"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015535", "l": "fucose:proton symporter activity"}, {"i": "RHEA:29023", "l": "H(+)(in) + L-fucose(in) = H(+)(out) + L-fucose(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-874084", "l": "IPAF is activated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61068", "l": "acetyl-CoA + horhammericine = 19-O-acetylhorhammericine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9724290", "l": "GNRHR2 binds GNRH1,2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635861", "l": "NUMB:ITCH binds GLI1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31732", "l": "3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 => 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982617", "l": "CYGB:O2 dissociates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48575", "l": "3,5-dichlorocatechol + O2 <=> (2E,4E)-2,4-dichloromuconate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65535", "l": "2-methylbutan-1-ol + hexanoyl-CoA <=> 2-methylbutyl hexanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36450", "l": "ATP + glycyl-L-proline(out) + H2O <=> ADP + glycyl-L-proline(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34896", "l": "ATP + H2O + selenite(out) => ADP + H(+) + phosphate + selenite(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050622", "l": "glycine dehydrogenase (cyanide-forming) activity"}, {"i": "MetaCyc:1.4.99.5-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389762", "l": "Phosphorylation of PD-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22779", "l": "2 H(+) + H2O2 + 2 Mn(2+) <=> 2 H2O + 2 Mn(3+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216988", "l": "Monoubiquitination of PCNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102180", "l": "4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174493", "l": "Glycosylation of ENV polyprotein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5695980", "l": "ACAD10 dehydrogenates S-2MPDA-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10425", "l": "H2O + N-benzoylglycine => benzoate + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47281", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40972", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26336", "l": "2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O <=> 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1364043", "l": "Tyrosine phosphorylation of PRLR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15698", "l": "liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + licodione + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380200", "l": "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196964", "l": "RFK:Mg2+ phosphorylates RIB (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109702", "l": "PDPK1 phosphorylates AKT2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-196929", "l": "FLAD1 phosphorylates FMN (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102274", "l": "glutathione S-conjugate carboxypeptidase activity"}, {"i": "MetaCyc:RXN-12532"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49627", "l": "ATP + erythritol <=> ADP + D-erythritol 1-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202718", "l": "Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36790", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-galactosamine <=> N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14929", "l": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53989", "l": "H2O + O-phospho-L-threonyl-[myosin light chain] => L-threonyl-[myosin light chain] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17929", "l": "an N-acylsphing-4-enine + ATP = ADP + an N-acylsphing-4-enine 1-phosphate + H(+)"}, {"i": "EC:2.7.1.138", "l": "\"Ceramide kinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0043176", "l": "amine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617483", "l": "HOXA2 gene is transcribed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134954", "l": "DHX9 binds DNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856223", "l": "B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24310", "l": "7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61780", "l": "keto-L-tagatose = keto-L-sorbose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37516", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA => 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433501", "l": "Interaction of other adapter proteins with p-KIT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28025", "l": "ATP + holo-[ACP] + octanoate <=> AMP + diphosphate + octanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429663", "l": "SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61267", "l": "H2O + L-alanine + O2 <=> H2O2 + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22072", "l": "ATP + L-ribulose = ADP + H(+) + L-ribulose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102633", "l": "flaviolin monooxygenase activity"}, {"i": "MetaCyc:RXN-15585"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35804", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O => 7,8-dihydroneopterin 2'-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854222", "l": "TBC1D3 associates with RAB5 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40170", "l": "hexadecanoyl-CoA + O2 <=> (2E)-hexadecenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51727", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate <=> adenosine 5'-tetraphosphate + ADP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102205", "l": "cholesterol alpha-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0016752", "l": "sinapoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.366", "l": "\"L-idonate 5-dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47905", "l": "ATP + N-(acetyl)-sphing-4-enine => ADP + H(+) + N-(acetyl)-sphing-4-enine-1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193703", "l": "IKKbeta is activated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008476", "l": "RUNX2 binds GSK3B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59246", "l": "acetate + ADP-D-ribose + H(+) => 3''-O-acetyl-ADP-D-ribose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53074", "l": "2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65493", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine => 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + CO2 + L-methionine"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0043130", "l": "ubiquitin binding"}, {"i": "REACT:R-HSA-983152", "l": "Transfer of ubiquitin from E1 to E2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60761", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-jasmololone => CoA + jasmolin II"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20970", "l": "2-dehydro-3-deoxy-L-arabinonate + H2O => L-arabinonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58996", "l": "H2O + indole-3-carbaldehyde + O2 = H(+) + H2O2 + indole-3-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39926", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-octadecyl-sn-glycerol + H(+) + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29441", "l": "Fe(2+)(out) + H(+)(in) => Fe(2+)(in) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205306", "l": "Interaction of SHP1 and KIT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0016494", "l": "C-X-C chemokine receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693761", "l": "FA2H hydroxylates CERA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660890", "l": "Defective SLC7A9 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45152", "l": "3-hydroxy-3-(methylsulfanyl)propanoyl-CoA = 3-oxopropanoyl-CoA + methanethiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24326", "l": "1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP(+) => 6-oxocineole + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19625", "l": "L-threonine = acetaldehyde + glycine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004401", "l": "histidinol-phosphatase activity"}, {"i": "RHEA:14465", "l": "H2O + L-histidinol phosphate = L-histidinol + phosphate"}, {"i": "EC:3.1.3.15", "l": "\"Histidinol-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22339", "l": "glycine betaine + L-homocysteine <=> L-methionine + N,N-dimethylglycine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030755", "l": "quercetin 3-O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877620", "l": "ECE2 cleaves EDN1(53-90) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55830", "l": "6beta-hydroxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cortisol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52786", "l": "A + ergothioneine + H2O => 2-sulfenohercynine + AH2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392530", "l": "p-S400-Cot phosphorylates NIK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62732", "l": "(+)-isomalbrancheamide B + bromide + FAD + 2 H(+) = (+)-isomalbrancheamide D + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696271", "l": "RND1 binds effectors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864466", "l": "TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers and YY1 stimulate ERBB2 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58162", "l": "diphosphate + dolabradiene => ent-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48864", "l": "2-methylpropan-1-amine + FADH2 + O2 = FAD + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27418", "l": "2 [Fe(III)cytochrome] + H2O + nicotinate => 6-hydroxynicotinate + 2 [Fe(II)cytochrome] + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788623", "l": "p-Y-STATs translocate to nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48145", "l": "H2O + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-(octadecanoyl)-sphing-4-enine => ganglioside GT1b (d18:1(4E)/18:0) + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156678", "l": "Activation of Cdc25C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685605", "l": "SLAMF7 binds SLAMF7 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-947535", "l": "Cyclisation of GTP to precursor Z (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17772", "l": "choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64987", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004630", "l": "phospholipase D activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10783", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) <=> 3-(4-hydroxyphenyl)pyruvate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32997", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA => a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52775", "l": "7,8-dihydroneopterin 3'-triphosphate <=> 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811479", "l": "ING2 recruits EP300 to TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43481", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11879", "l": "NAD(+) + prostaglandin E2 <=> 15-oxoprostaglandin E2 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951951", "l": "RUNX3 binds EP300 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42311", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187575", "l": "Ubiquitination of phospho-p27/p21 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102087", "l": "N-benzoyl-L-glutamate synthetase activity"}, {"i": "MetaCyc:RXN-10886"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1964496", "l": "STING binds TRIM32 or TRIM56  (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061676", "l": "importin-alpha family protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877192", "l": "RUNX1 binds FOXP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103023", "l": "ITPase activity"}, {"i": "RHEA:28330", "l": "H2O + ITP = H(+) + IDP + phosphate"}, {"i": "MetaCyc:RXN0-5073"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63357", "l": "(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + O2 => (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-thiazole-[protein] + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375384", "l": "Bombesin-like receptors bind bombesin homologues (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42373", "l": "16-methoxytabersonine + H2O => (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021325", "l": "NOTCH3 coactivator complex and STAT1 bind HES1 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781899", "l": "USP13 binds SIAH2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1236970", "l": "Proteasomal clevage of exogenous antigen (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55825", "l": "a 7(1),7(1)-dihydroxybacteriochlorophyllide d => a bacteriochlorophyllide f + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57594", "l": "(2S)-2-hydroxypinocembrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-pinocembrin + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696271", "l": "RND1 binds effectors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22478", "l": "4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH => 4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "79.682896251205548", "identifiers": [{"i": "GO:0019783", "l": "ubiquitin-like protein-specific protease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23404", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate"}, {"i": "EC:2.5.1.41", "l": "\"Phosphoglycerol geranylgeranyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875591", "l": "DOCK7 activates RAC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182263", "l": "Degradation of MHC I Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13545", "l": "(6E,10E)-geranyllinalool + O2 + reduced [NADPH--hemoprotein reductase] = (3E,7E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.58", "l": "\"Trimethyltridecatetraene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60766", "l": "cinerin II + CoA => (1R,3R)-pyrethroyl-CoA + (Z,S)-cinerolone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50014", "l": "2-methylpropane-1,2-diol + H2O + NADP(+) => H(+) + NADPH + O2 + tert-butanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17986", "l": "4-(trimethylamino)butanal + H2O + NAD(+) => 4-(trimethylamino)butanoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47215", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.140", "l": "\"Gluconate/galactonate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53508", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione = (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686920", "l": "PELI1 ubiquitinates RIPK3 at K363 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4088130", "l": "PLK1 binds FOXM1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24726", "l": "N-demethylindolmycin + S-adenosyl-L-methionine = H(+) + indolmycin + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.328", "l": "\"N-demethylindolmycin N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9667914", "l": "ALK binds ligand midkine (MDK) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11152", "l": "5-pyridoxate + NADPH + O2 = 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+)"}, {"i": "EC:1.14.13.241", "l": "\"5-pyridoxate monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781899", "l": "USP13 binds SIAH2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109700", "l": "AKT2 binds PIP3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689000", "l": "AADAC deacetylates PHEN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22563", "l": "(3R)-vestitone + NADP(+) <=> 2'-hydroxyformononetin + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784734", "l": "PCSK9 binds LDLR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854738", "l": "CSF3 dimer:CSFR binds CSFR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51964", "l": "2-methylpropanenitrile + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2-methylpropanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42503", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) <=> 6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35034", "l": "L-serine(in) <=> L-serine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.17", "l": "\"Pro-opiomelanocortin converting enzyme\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785607", "l": "FANCM binds FAAP24 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021357", "l": "PRKCI phosphorylates ELF3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785898", "l": "IL4R binds JAK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20077", "l": "guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.34", "l": "\"tRNA (guanosine(18)-2'-O)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16148", "l": "2 [Fe(II)-cytochrome b5] + CMP-N-acetyl-beta-neuraminate + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + CMP-N-glycoloyl-beta-neuraminate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156661", "l": "Formation of Exon Junction Complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12154", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+) => (3R,4S,5S,6R)-pentachlorocyclohexene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13431", "l": "4-CDP-2-C-methyl-D-erythritol + diphosphate => 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192061", "l": "CYP46A1 24-hydroxylates CHOL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-996755", "l": "ZFPM proteins bind GATA proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158860", "l": "SULT1A1 dimer sulfonates NHABP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40436", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => H(+) + hexadecanoate + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.1", "l": "\"Beta-galactoside alpha-(2,6)-sialyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036424", "l": "L-phosphoserine phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59342", "l": "1'-hydroxy-demethylspheroidene + AH2 => 1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690873", "l": "ACO1 binds 4Fe-4S (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814409", "l": "CK2 phosphorylates PDCL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13046", "l": "ent-kaur-16-ene + O2 + reduced [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59004", "l": "dodecanal + H2O + O2 = dodecanoate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42807", "l": "5,6,7,8-tetrahydromethanopterin + A <=> 7,8-dihydromethanopterin + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110215", "l": "Cleavage of uracil by UNG glycosylase (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65691", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(38-hydroxyoctatriacontenoyl)-sphing-4-enine <=> a diacylglycerol + an N-(38-(9Z,12Z-octadecadienoyloxy)-octatriacontenoyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032751", "l": "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534359", "l": "CatSper Channel Mediated Calcium Transport (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45219", "l": "[methyl-Co(III) dimethylamine-specific corrinoid protein] + coenzyme M <=> [Co(I) dimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12667", "l": "an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+) => a 2-deoxystreptamine antibiotic + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32870", "l": "myo-inositol(out) <=> myo-inositol(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110437", "l": "DILP binds to Drosophila insulin receptor (DINR) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-437139", "l": "ZnT6 transports zinc into the golgi apparatus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20756", "l": "(E)-caffeoyl-CoA + D-threo-isocitrate = 2-[(E)-caffeoyl]-D-threo-isocitrate(3-) + CoA"}, {"i": "EC:2.3.1.126", "l": "\"Isocitrate O-dihydroxycinnamoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.9.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53965", "l": "4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + ribostamycin => gamma-L-glutamyl-butirosin B + H(+) + holo-[BtrI ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902388", "l": "ceramide 1-phosphate transfer activity"}, {"i": "REACT:R-HSA-5339535", "l": "GLTPD1 transports C1P from plasma membrane to Golgi membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417843", "l": "P2Y13 binds ADP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64837", "l": "2-phenylethanol + acetyl-CoA => CoA + phenethyl acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33260", "l": "4-aminoimidazole + H(+) + 2 H2O => N-formimidoylglycine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36709", "l": "O-ureido-D-serine => O-ureido-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25579", "l": "3 O2 + protoporphyrinogen IX <=> 3 H2O2 + protoporphyrin IX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602454", "l": "proMMP9 binds TIMP1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381727", "l": "RAP1A exchanges GDP for GTP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046180", "l": "KSPG is secreted from the cell (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61138", "l": "CO2 + H(+) + H2O + quercetin + succinate => (2R,3R)-dihydroquercetin + 2-oxoglutarate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23772", "l": "(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) = 2,3-dihydroxy-p-cumate + H(+) + NADH"}, {"i": "EC:1.3.1.58", "l": "\"2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43263", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60514", "l": "an N(7)-methylguanosine in miRNA + S-adenosyl-L-homocysteine => a guanosine in miRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9617927", "l": "FOXO4 binds ATXN3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.17"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40011", "l": "(+)-copalyl diphosphate + H2O = diphosphate + manool"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10669", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) => 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8863727", "l": "STON2 is neddylated (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12260", "l": "ATP + NADH = ADP + H(+) + NADPH"}, {"i": "EC:2.7.1.86", "l": "\"NADH kinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0016426", "l": "tRNA (adenine) methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9006844", "l": "IL21:IL21R:JAK1 binds IL2RG:JAK3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22515", "l": "3 H(+) + precorrin-8X <=> hydrogenobyrinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222655", "l": "AhpD reactivates AhpC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35926", "l": "neamine + UDP-alpha-D-glucose <=> 3''-deamino-3''-hydroxykanamycin B + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39147", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + CoA = (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39479", "l": "(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADPH = (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2106625", "l": "Duplex siRNA is loaded into Argonaute (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17552", "l": "1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine <=> 1-acyl-2-(10-methylene)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57926", "l": "diphosphate + premutilin => H2O + mutildienyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015371", "l": "galactose:sodium symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205136", "l": "GTP-bound RAC contributes to JNK activation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850997", "l": "TRIM27 binds PTEN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37161", "l": "1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061751", "l": "neutral sphingomyelin phosphodiesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022625", "l": "MECP2 binds FOXG1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23808", "l": "(S)-scoulerine + S-adenosyl-L-methionine = (S)-tetrahydrocolumbamine + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.117", "l": "\"(S)-scoulerine 9-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28219", "l": "chloride + H(+) + H2O2 => H2O + hypochlorous acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3777129", "l": "HDAC3 containing complexes deacetylate histone (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56200", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-alpha-D-galactose = H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57725", "l": "H(+) + 2 Na(+)(in) + oxaloacetate => CO2 + 2 Na(+)(out) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371353", "l": "Soluble TNF-alpha binds TNFR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62249", "l": "chloroacetaldehyde + H2O + NADP(+) => chloroacetate + 2 H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48380", "l": "alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = a neolactoside IV(3)-alpha-Gal,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.-", "l": "\"With NADH or NADPH as one donor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803719", "l": "TP53 binds ZNF385A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806629", "l": "Formation of tonofilament bundles (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209566", "l": "TRAF6 is auto-ubiquitinated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63649", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28555", "l": "D-mannose 6-phosphate + H2O => D-mannose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73806", "l": "AIR + CO2 => CAIR (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50562", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-tryptophyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19683", "l": "AMP + biotinyl-CoA + diphosphate => ATP + biotin + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0033285", "l": "ATPase-coupled monocarboxylic acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38017", "l": "6-geranylgeranyl-2-methylbenzene-1,4-diol => delta-tocotrienol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63012", "l": "(2E,6E)-farnesyl diphosphate + orsellinate = diphosphate + ilicicolinate B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39661", "l": "1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine => 3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617412", "l": "Expression of GLI1 is repressed by GLI3R in the absence of Hh signaling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63452", "l": "3-[(R)-glyceryl]-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin = GMP + H(+) + oxidized 3PG-factor420-0"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28375", "l": "ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69685", "l": "CHEK2 phosphorylates TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8980691", "l": "RHOA GEFs activate RHOA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65458", "l": "2-methylbutyl acetate + CoA => 2-methylbutan-1-ol + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44561", "l": "4-hydroxybenzoate + all-trans-heptaprenyl diphosphate => 4-hydroxy-3-all-trans-heptaprenylbenzoate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62613", "l": "adenosine(1832) in 18S rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(1832) in 18S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19202", "l": "2'-deoxyguanosine + ATP => ADP + dGMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58452", "l": "N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45357", "l": "H2O + N-(11Z-eicosenoyl)-sphing-4-enine => (11Z)-eicosenoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668335", "l": "CHMP7 binds LEMD2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52814", "l": "(9Z,12Z)-octadecadienoate + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H(+) => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53380", "l": "5,6-dihydrouridine(16) in tRNA + NAD(+) = H(+) + NADH + uridine(16) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25236", "l": "N-acetyl-alpha-neuraminate <=> N-acetyl-beta-neuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655142", "l": "RCHY1 binds POLH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047610", "l": "acetylsalicylate deacetylase activity"}, {"i": "RHEA:11752", "l": "acetylsalicylate + H2O = acetate + H(+) + salicylate"}, {"i": "EC:3.1.1.55", "l": "\"Acetylsalicylate deacetylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617874", "l": "HOXD4 gene is transcribed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34308", "l": "4-nitrocatechol + NADPH + O2 => 2-hydroxy-1,4-benzoquinone + H2O + NADP(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358789", "l": "Self-ubiquitination of RNF41 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11113", "l": "H2O + isochorismate => (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210836", "l": "HNF6-dependent synthesis of NEUROG3 protein during morphogenesis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29601", "l": "H(+) + H2O + monacolin J carboxylate + oxidized [NADPH--hemoprotein reductase] => monacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42881", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermine => H(+) + N(4)-aminopropylspermine + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59501", "l": "5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696816", "l": "tRNA ligase complex ligates tRNA exons (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30643", "l": "phosphate + S-methyl-5'-thioinosine = hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate"}, {"i": "EC:2.4.2.44", "l": "\"S-methyl-5'-thioinosine phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51610", "l": "(R)-lactate + 2-oxoglutarate => (R)-2-hydroxyglutarate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48919", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b <=> CMP + ganglioside GD1c + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36317", "l": "CoA + hexadecan-1-ol + 2 NADP(+) => 2 H(+) + hexadecanoyl-CoA + 2 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211951", "l": "CYP1B1 4-hydroxylates EST17b (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047182", "l": "alcohol O-cinnamoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35464", "l": "5alpha-cholest-7-en-3beta-ol + NAD(+) => 5alpha-cholest-7-en-3-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57138", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphoserine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202722", "l": "CD48 binds CD244 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66454", "l": "1-(9Z)-octadecenoylglycerone 3-phosphate + H(+) + NADPH => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10282", "l": "caffeine + H(+) + S-adenosyl-L-homocysteine => 1,7-dimethylxanthine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54248", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700175", "l": "Active ALK phosphorylates SHC1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373751", "l": "UNC-5 binds Netrin-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701485", "l": "Active ALK binds JAK3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18180", "l": "a 2,3-saturated acyl-CoA + NAD(+) <=> a (2E)-enoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35601", "l": "3-hydroxypropanal + H(+) + NADPH => NADP(+) + propane-1,3-diol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47301", "l": "(9Z)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863471", "l": "LDLR is bound by DAB2 and ARH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140679", "l": "ABC-type sodium transporter activity"}, {"i": "EC:7.2.2.4", "l": "\"ABC-type Na(+) transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850797", "l": "SPINK6 binds KLK13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30293", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009392", "l": "N-acetyl-anhydromuramoyl-L-alanine amidase activity"}, {"i": "MetaCyc:RXN0-5225"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32301", "l": "2 diphosphate + NAD(+) + squalene => 2 (2E,6E)-farnesyl diphosphate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102539", "l": "UDP-N-acetyl-alpha-D-fucosamine dehydrogenase activity"}, {"i": "MetaCyc:RXN-14769"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48375", "l": "1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O <=> a fatty acid + acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36403", "l": "a cholesterol ester + H2O = a fatty acid + cholesterol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13663", "l": "N-formyl-L-aspartate + NH4(+) => H2O + N-formimidoyl-L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381668", "l": "cAMP activates EPAC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58505", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate => (3Z)-2-oxo-4-carboxy-3-hexenedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74258", "l": "XDH oxidizes xanthine to form urate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183122", "l": "Factor D cleaves C3b-bound Factor B (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50358", "l": "4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+) => 4-hydroxy-6-methylpretetramide + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56435", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203070", "l": "Association of profilin with monomeric actin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59566", "l": "H(+) + N,N',N'',N'''-tetraacetylchitotetraonate => H2O + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-532549", "l": "MPI isomerises Fru6P to Man6P (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "78.047734625335977", "identifiers": [{"i": "GO:0046992", "l": "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond"}, {"i": "EC:1.21.-.-", "l": "\"Catalyzing the reaction X-H + Y-H = 'X-Y'\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19041", "l": "(25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase] = (25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "RHEA:24308", "l": "25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.29", "l": "\"25/26-hydroxycholesterol 7-alpha-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400204", "l": "PPARA binds RXRA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004799", "l": "thymidylate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380586", "l": "loading of Serotonin in synaptic vesicles (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264997", "l": "Oxidation of cysteine to cystine in Proinsulin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45177", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082391", "l": "Trimerization of HSF1 in the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983266", "l": "Kinesins bind microtubules (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295613", "l": "SPRY2 binds GRB2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12069", "l": "apo-[ACP] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.57"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-435244", "l": "PECAM1 is phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031955", "l": "short-chain fatty acid-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10900", "l": "an aromatic L-alpha-amino acid + glyoxylate = an aromatic oxo-acid + glycine"}, {"i": "EC:2.6.1.60", "l": "\"Aromatic-amino-acid--glyoxylate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53421", "l": "8-demethyl-8-(methylamino)riboflavin + S-adenosyl-L-methionine => H(+) + roseoflavin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38841", "l": "1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15150", "l": "O2 + pyridoxine 5'-phosphate => H2O2 + pyridoxal 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.3", "l": "\"Ficain\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167097", "l": "HIV Promoter Opening: First Transition (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937050", "l": "Pellino ubiquitinates hp-IRAK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0005237", "l": "inhibitory extracellular ligand-gated ion channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56785", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + (n-1) H2O => (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48076", "l": "a primary alcohol + N,N-dimethyl-4-nitrosoaniline = 4-(hydroxylamino)-N,N-dimethylaniline + an aldehyde"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047892", "l": "flavone apiosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418856", "l": "Activation of Rac1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61023", "l": "acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA <=> 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417843", "l": "P2Y13 binds ADP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15138", "l": "galactitol 1-phosphate + NAD(+) => H(+) + keto-L-tagatose 6-phosphate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50604", "l": "acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein]"}, {"i": "EC:2.3.1.259", "l": "\"N-terminal methionine N(alpha)-acetyltransferase NatF\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48252", "l": "ganglioside GD2 + UDP-alpha-D-galactose = ganglioside GD1b + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30173", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP] => hexadecanoyl-[ACP] + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23863", "l": "acetyl-CoA + deacetylcephalosporin C <=> cephalosporin C + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634228", "l": "TRAF1 is cleaved by caspases (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17746", "l": "N-acetyl-D-glucosamine + UDP-alpha-D-galactose => beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952371", "l": "MDM2 binds RUNX3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48358", "l": "GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.27"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62306", "l": "(+)-premalbrancheamide => 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264435", "l": "Dissociation of the COP1-p53 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000309", "l": "nicotinamide-nucleotide adenylyltransferase activity"}, {"i": "MetaCyc:2.7.7.1-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36078", "l": "AH2 + an N-acylsphinganine + O2 <=> A + an N-acylsphing-4-enine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018746", "l": "RHOQ binds effectors at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65656", "l": "A + cholest-1,4-dien-3-one + H2O = 25-hydroxycholest-1,4-dien-3-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41827", "l": "3-oxohexanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyhexanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110130", "l": "ribitol-5-phosphatase activity"}, {"i": "RHEA:47648", "l": "D-ribitol 5-phosphate + H2O = phosphate + ribitol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685230", "l": "CHEK1 phosphorylates RAD51 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77077", "l": "Capping complex formation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2534365", "l": "Slo3 Potassium Transport (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28498", "l": "formaldehyde + mycothiol = S-(hydroxymethyl)mycothiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48143", "l": "2 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 oxidized [2Fe-2S]-[ferredoxin] + red chlorophyll catabolite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37644", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102357", "l": "mithramycin dehydrogenase activity"}, {"i": "MetaCyc:RXN-13385"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21284", "l": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65483", "l": "2-methylbutanoyl-CoA + hexan-1-ol <=> CoA + hexyl 2-methylbutanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047599", "l": "8-oxocoformycin reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693783", "l": "NAALADases hydrolyse NAAG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31796", "l": "(+)-beta-caryophyllene + H2O => (+)-caryolan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32012", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-T-muurolol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449077", "l": "Interleukin-16 is secreted (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418172", "l": "F2R binds ARRB2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46880", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016155", "l": "formyltetrahydrofolate dehydrogenase activity"}, {"i": "KEGG.REACTION:R00941"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879594", "l": "SLCO4C1 mediates the transport of digoxin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59486", "l": "2 [Fe(II)cytochrome c] + arsenate + 3 H(+) => 2 [Fe(III)cytochrome c] + arsenite + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34709", "l": "5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane => AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983150", "l": "Proteasomal cleavage of substrate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371527", "l": "HSF1 trimer translocates to the nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110459", "l": "PIP3 dephosphorylated to PIP2 by DPTEN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52370", "l": "adenosine 3',5'-bisphosphate + cholesterol sulfate + H(+) => 3'-phosphoadenylyl sulfate + cholesterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693071", "l": "BACE1 translocates from ER lumen to Golgi apparatus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48576", "l": "4-chlorocatechol + O2 = 3-chloro-cis,cis-muconate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59968", "l": "L-threonyl-[protein] + octanoyl-CoA = CoA + O-octanoyl-L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030734", "l": "polysaccharide O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.68", "l": "\"T-plasminogen activator\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55117", "l": "5-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-5-methylhexanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47550", "l": "3-oxochola-4,6-dien-24-oate + H2O => 7alpha-hydroxy-3-oxochol-4-en-24-oate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30141", "l": "CoA + H(+) + octadecanoate => H2O + octadecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694563", "l": "ABHD10 hydrolyses MPAG (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17368", "l": "ATP + H2O + Mn(2+)(out) <=> ADP + H(+) + Mn(2+)(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10823", "l": "D-threo-isocitrate <=> D-erythro-isocitrate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15292", "l": "[(1->4)-beta-D-xylan](n) + UDP-alpha-D-xylose <=> [(1->4)-beta-D-xylan](n+1) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159795", "l": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64782", "l": "2-aminoprop-2-enoate + benzylthiol => S-benzyl-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5653957", "l": "Rag dimer formation (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5662608", "l": "MT2A binds cadmium (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30508", "l": "2-demethylmenaquinone-8 + H(+) + NADH => 2-demethylmenaquinol-8 + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66053", "l": "indole-3-pyruvate + L-kynurenine => H2O + kynurenate + L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15029", "l": "D-mannitol + NAD(+) = D-mannose + H(+) + NADH"}, {"i": "EC:1.1.1.255", "l": "\"Mannitol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193097", "l": "Pregnenolone translocates from the mitochondrial matrix to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44031", "l": "L-altrarate <=> 5-dehydro-4-deoxy-D-glucarate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016034", "l": "maleylacetoacetate isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17096", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033520", "l": "TYSND1 cleaves TYSND1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66909", "l": "acetyl-CoA + 20 H(+) + 9 malonyl-CoA + 13 NADPH + S-adenosyl-L-methionine => 9 CO2 + 10 CoA + 7 H2O + 13 NADP(+) + S-adenosyl-L-homocysteine + soppiline A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17180", "l": "(R)-carnitine + octanoyl-CoA <=> CoA + O-octanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40827", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199404", "l": "CD40L binds CD40 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.90", "l": "\"Togavirin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51309", "l": "H(+) + L-methionyl-[F-actin] + NADPH + O2 => H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106366", "l": "guanosine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31137", "l": "5-amino-4-imidazolecarboxyamide + 5-phospho-alpha-D-ribose 1-diphosphate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64748", "l": "H2O + S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine = 2-methyl-3-sulfanylbutan-1-ol + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102718", "l": "TRIBOA-glucoside methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22729", "l": "H(+) + L-seryl-tRNA(Sec) + selenophosphate => L-selenocysteinyl-tRNA(Sec) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0089721", "l": "phosphoenolpyruvate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27954", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + presilphiperfolan-8beta-ol"}, {"i": "EC:4.2.3.74", "l": "\"Presilphiperfolanol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004164", "l": "diphthine synthase activity"}, {"i": "RHEA:20145", "l": "2-(3-amino-3-carboxypropyl)-L-histidine + S-adenosyl-L-methionine = 2-[3-carboxy-3-(methylammonio)propyl]-L-histidine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40943", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27549", "l": "anthranilate + FADH2 + O2 <=> 3-hydroxyanthranilate + FAD + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000247", "l": "Endosomal CBLIF:Cbl translocates to lysosome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50788", "l": "NADP(+) + pentan-2-one = (E)-pent-3-en-2-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48478", "l": "ganglioside GD1a (d18:1(4E)) + N-acetylneuraminate => ganglioside GT1a (d18:1(4E)) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24559", "l": "5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+) <=> 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358512", "l": "MLH1:PMS2 makes single strand incision near  insertion/deletion loop of 2 bases or more (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50478", "l": "CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein] => anthraniloyl-CoA + L-cysteinyl-[PqsD protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031132", "l": "serine 3-dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789524", "l": "Expression of IL4,IL13-downregulated extracellular genes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39911", "l": "(2S,3S)-3-methylphenylalanine + 2-oxoglutarate = (3S)-2-oxo-3-phenylbutanoate + L-glutamate"}, {"i": "EC:2.6.1.107", "l": "\"Beta-methylphenylalanine transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3000327", "l": "PLK1 phosphorylates BORA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22893", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) => 5,10-methenyltetrahydrofolate + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061513", "l": "glucose 6-phosphate:inorganic phosphate antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947499", "l": "Exchange of oxygen with sulfur in MoCo (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39833", "l": "2-hydroxyhexadecanoate + 2 [Fe(III)-cytochrome b5] + H2O => 2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33131", "l": "L-phenylalanine + tetrahydro-4-hydroxyphenylpyruvate = 3-phenylpyruvate + tetrahydrotyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27560", "l": "(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate => all-trans-hexaprenyl diphosphate + 3 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53705", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O => H(+) + prostaglandin E2 + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52290", "l": "7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20407", "l": "(2S,6S)-2,6-diaminoheptanedioate + acetate => H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912470", "l": "ATR phosphorylates Histone H2A.X at unsynapsed regions (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52802", "l": "AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid => acetoacetyl-CoA + ATP + L-isoleucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40578", "l": "glutaryl-CoA + H2O <=> CoA + glutarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24127", "l": "all-trans-retinal <=> 11-cis-retinal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22255", "l": "globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> globoside Gb4Cer (d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15015", "l": "secologanin + tryptamine => 3alpha(S)-strictosidine + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102369", "l": "11alpha-30-dihydroxy beta-amyrin dehydrogenase activity"}, {"i": "MetaCyc:RXN-13491"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3797202", "l": "AP-1 stimulates transcription of IGFBP7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983150", "l": "Proteasomal cleavage of substrate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952069", "l": "HDAC4 deacetylates RUNX3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5099899", "l": "WNT5A binds FZD4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196964", "l": "RFK:Mg2+ phosphorylates RIB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013284", "l": "NOTCH3-ligand complex is cleaved to produce NEXT3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202241", "l": "Recruitment of SLP-76 to Gads (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11599", "l": "H(+) + orotidine 5'-phosphate <=> CO2 + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21109", "l": "(S)-3-methyl-2-oxopentanoate + H(+) => 2-methylbutanal + CO2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102951", "l": "indole-3-acetyl-phenylalanine synthetase activity"}, {"i": "MetaCyc:RXN-9084"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59894", "l": "chloride + H(+) + L-propargylglycine => L-2-amino-4-chloropent-4-enoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12095", "l": "(S)-acetoin <=> (R)-acetoin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46890", "l": "3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + H2O2 => 3-deoxy-alpha-D-manno-oct-2-ulosonate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-879459", "l": "F-actin capping protein is a heterodimer (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050042", "l": "lactate-malate transhydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190788", "l": "Formation of junctional channels (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936380", "l": "Interaction of PIN1 with p-IRF3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204813", "l": "Interaction of Tie2 and Grb14 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18047", "l": "alpha-D-glucose 1-phosphate + alpha-D-mannose derivative + H(+) => 6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28402", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A = ADP + H(+) + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32118", "l": "2-oxoglutarate + DIBOA beta-D-glucoside + O2 <=> CO2 + succinate + TRIBOA beta-D-glucoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16595", "l": "3,3',4',5,7-pentahydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174203", "l": "SCF-mediated degradation of Emi1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72631", "l": "Formation of the cap-binding eIF4F complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45083", "l": "3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine <=> ADP + dapdiamide E + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70241", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003885", "l": "D-arabinono-1,4-lactone oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27571", "l": "ATP + D-glycero-alpha-D-manno-heptose 7-phosphate => ADP + D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59485", "l": "2 [Fe(III)cytochrome c] + arsenite + H2O => 2 [Fe(II)cytochrome c] + arsenate + 3 H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043918", "l": "cadaverine aminopropyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047785", "l": "cortisol sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0043539", "l": "protein serine/threonine kinase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52298", "l": "10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8934688", "l": "RUNX1:CBFB binds the LIFR gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-918232", "l": "Recruitment of IRF3,IRF7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007999", "l": "RUNX2 translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010815", "l": "SLITs bind keratan sulfate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44117", "l": "eicosan-1-ol + hexadecanoyl-CoA => CoA + eicosanyl hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21037", "l": "2 acetyl-CoA => acetoacetyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13807", "l": "a 3-oxo-Delta(4)-steroid + AH2 => A + a 3-oxo-5alpha-steroid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24564", "l": "a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50325", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] => 1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52188", "l": "1-aci-nitro-2-(1H-indol-3-yl)ethane + glutathione = (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694563", "l": "ABHD10 hydrolyses MPAG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58006", "l": "(20S)-ginsenoside Rd + H(+) + UDP => (20S)-ginsenoside F2 + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13915", "l": "D-threonine => L-threonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59899", "l": "ATP + L-glutamate + L-propargylglycine <=> ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22401", "l": "androstan-3alpha,17beta-diol + NAD(+) => 17beta-hydroxyandrostanone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008267", "l": "poly-glutamine tract binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15608", "l": "H2O + L-serine O-sulfate <=> H(+) + NH4(+) + pyruvate + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1462003", "l": "HNP1-4 are stored in primary neutrophil granules (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853429", "l": "PHLDA1 binds AURKA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41668", "l": "dihydrochelirubine + NADP(+) = chelirubine + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50505", "l": "acetyl-CoA + N-terminal L-seryl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848250", "l": "ACBD6 binds LCFA-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672168", "l": "Ligand-independent dimerization of PDGFR mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44320", "l": "1-decanoylglycerol + H2O = decanoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61662", "l": "(2E)-geranyl phosphate + ADP + H(+) => (2E)-geraniol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032770", "l": "Translocation of YAP1 to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56070", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-alpha-D-glucosaminyl derivative + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5138432", "l": "DVL2 is phosphorylated by PKC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418925", "l": "ADORA2A,B bind Ade-Rib (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322429", "l": "XIAP monoubiquinates TLE (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40188", "l": "(2E)-octenoyl-CoA + H2O => (3R)-hydroxyoctanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615570", "l": "miR-137 binds PTEN mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25712", "l": "L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791109", "l": "GADD45A binds PCNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63264", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + O2 = 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-481007", "l": "Exocytosis of platelet alpha granule contents (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44428", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + glycerol = a 1-acyl-sn-glycero-3-phosphocholine + a 1-acylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9660557", "l": "RAS:GTP binds RAL GDS proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13801", "l": "3 H2O + hydrogen sulfide + 3 NADP(+) = 4 H(+) + 3 NADPH + sulfite"}, {"i": "EC:1.8.1.2", "l": "\"Assimilatory sulfite reductase (NADPH)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18783", "l": "acetyl-CoA + CO2 => H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64307", "l": "1-phenylpropylamine + pyruvate <=> 1-phenylpropan-1-one + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33379", "l": "4-hydroxyeicosasphinganine 1-phosphate + H2O = (4R)-hydroxyeicosasphinganine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38913", "l": "26-desgluco-avenacoside B + D-glucose => avenacoside B + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875817", "l": "MET phosphorylates STAT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33460", "l": "H(+) + NADPH + zymosterone => 5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42247", "l": "H(+) + malonyl-[ACP] + propanoyl-CoA <=> 3-oxopentanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671993", "l": "CIT-3 binds DLG4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035727", "l": "lysophosphatidic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4090288", "l": "PIAS1,3 SUMOylate MBD1 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8949580", "l": "F1Fo ATP synthase dimerizes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "71.632434359930443", "identifiers": [{"i": "GO:0016780", "l": "phosphotransferase activity, for other substituted phosphate groups"}, {"i": "REACT:R-HSA-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23847", "l": "ATP + sedoheptulose <=> ADP + D-sedoheptulose 7-phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62968", "l": "(R)-lactate + NADP(+) = H(+) + NADPH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53834", "l": "a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate => 2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38354", "l": "(R)-3-phenyllactate + NAD(+) <=> 3-phenylpyruvate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44015", "l": "(9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA <=> (9Z)-hexadecenoyl-(Kdo)2-lipid IVA + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990576", "l": "G protein-coupled glucose receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14775", "l": "corydaline + 2 NADP(+) + S-adenosyl-L-homocysteine => 2 NADPH + palmatine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-481044", "l": "Surface deployment of platelet alpha granule membrane components (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649655", "l": "NEIL1 recognizes and binds DHU-dsDNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848250", "l": "ACBD6 binds LCFA-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23983", "l": "cyclomaltodextrin + H2O <=> linear maltodextrin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2514831", "l": "Fibrillin-1 degradation by MMP14 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12900", "l": "2-cis-(+)-abscisate + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-8'-hydroxyabscisate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019705", "l": "protein-cysteine S-myristoyltransferase activity"}, {"i": "RHEA:59736", "l": "L-cysteinyl-[protein] + tetradecanoyl-CoA = CoA + S-tetradecanoyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39482", "l": "(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADPH <=> (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247569", "l": "PADI4 deiminates Histones (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.15", "l": "\"N-sulfoglucosamine-3-sulfatase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009015", "l": "N-succinylarginine dihydrolase activity"}, {"i": "KEGG.REACTION:R04189"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41893", "l": "(3R)-hydroxytetradecanoyl-[ACP] => (2E)-tetradecenoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167415", "l": "G-protein alpha subunit is inactivated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70494", "l": "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "80.661393760018115", "identifiers": [{"i": "GO:0047661", "l": "amino-acid racemase activity"}, {"i": "MetaCyc:AMINO-ACID-RACEMASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19195", "l": "AH2 + all-trans-retinol => A + all-trans-13,14-dihydroretinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45688", "l": "N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(in) = N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22408", "l": "dimethylallyl diphosphate + isopentenyl diphosphate = (2E)-geranyl diphosphate + diphosphate"}, {"i": "EC:2.5.1.1", "l": "\"Dimethylallyltranstransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1982065", "l": "Ligand-independent dimerization of overexpressed FGFR1b (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097508", "l": "xanthine DNA N-glycosylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18202", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31066", "l": "3-methylbutanoyl-CoA + FAD + H(+) <=> 3-methyl-(2E)-butenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046871", "l": "N-acetylgalactosamine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27642", "l": "adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21943", "l": "AH2 + O2 + squalene <=> (S)-2,3-epoxysqualene + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031403", "l": "lithium ion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000074", "l": "TCII binds Cbl in the circulation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49273", "l": "alfacalcidol + O2 + reduced [NADPH--hemoprotein reductase] => calcitriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30219", "l": "dimethyl sulfoxide + H2O + NAD(+) = dimethyl sulfone + H(+) + NADH"}, {"i": "EC:1.8.1.17", "l": "\"Dimethylsulfone reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36994", "l": "phosphate + UMP <=> alpha-D-ribose 1,5-bisphosphate + uracil"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13035", "l": "keto-D-tagatose 6-phosphate => aldehydo-D-galactose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53579", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56407", "l": "[(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate pentamer + [(3R)-hydroxybutanoate](n-5) + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12606", "l": "D-glyceraldehyde 3-phosphate + H(+) + pyruvate => 1-deoxy-D-xylulose 5-phosphate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390061", "l": "YKI binds to phosphorylated WTS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45001", "l": "(R)-carnitine + 3-hydroxybutanoyl-CoA => CoA + O-3-hydroxybutanoyl-(R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170986", "l": "Ral-GDS binds to Ras-GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50986", "l": "prostaglandin E2(in) => prostaglandin E2(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050359", "l": "tropomyosin kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109701", "l": "PDPK1 binds PIP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11867", "l": "H(+) + H2O + oxidized [electron-transfer flavoprotein] + trimethylamine <=> dimethylamine + formaldehyde + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53182", "l": "D-erythrulose => D-erythrose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052616", "l": "ent-kaur-16-en-19-ol oxidase activity"}, {"i": "RHEA:21304", "l": "ent-kaur-16-en-19-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47359", "l": "an octanoate ester + H2O <=> an aliphatic alcohol + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55043", "l": "(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28839", "l": "H(+)(out) + Zn(2+)(in) = H(+)(in) + Zn(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.35", "l": "\"Barrierpepsin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43749", "l": "ATP + CoA + hexacosanoate => AMP + diphosphate + hexacosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18620", "l": "ATP + oxaloacetate <=> ADP + CO2 + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18444", "l": "D-dopachrome + H(+) <=> 5,6-dihydroxyindole + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4090281", "l": "PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070224", "l": "sulfide:quinone oxidoreductase activity"}, {"i": "REACT:R-HSA-1614665", "l": "SQR oxidizes sulfide to bound persulfide (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38387", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1,3-di-(9Z-octadecenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34019", "l": "a 1-acylglycerol + H2O = a fatty acid + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37241", "l": "H(+) + uridine 2'-phosphate => 2',3'-cyclic UMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626253", "l": "HSPA8 binds LAMP2a multimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983147", "l": "Release of E3 from polyubiquitinated substrate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56606", "l": "6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874979", "l": "ACBD3 binds GOLGB1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983707", "l": "SYK autophosphorylates at the activated BCR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26513", "l": "H2O + L-prolinamide <=> L-proline + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033719", "l": "2-oxo-acid reductase activity"}, {"i": "RHEA:23664", "l": "A + a (2R)-2-hydroxycarboxylate = a 2-oxocarboxylate + AH2"}, {"i": "EC:1.1.99.30", "l": "\"2-oxo-acid reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10413", "l": "ADP-D-ribose + H2O => AMP + D-ribose 5-phosphate + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.38"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15268", "l": "1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate <=> H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24795", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate => 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.15", "l": "\"(S)-2-hydroxy-acid oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16211", "l": "cob(II)yrinate => Co-precorrin-8X"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46956", "l": "hydrocaffeoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = (E)-caffeoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.3.1.108", "l": "\"Caffeoyl-CoA reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849878", "l": "PSD-95 binds NMDA receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0042922", "l": "neuromedin U receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38661", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34086", "l": "a (3R)-3-hydroxyacyl-CoA <=> a (3S)-3-hydroxyacyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390846", "l": "D2D3,4 bind to DA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849102", "l": "SRMS phosphorylates PTK6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36685", "l": "CoA + S-hexadecanoyl-L-cysteinyl-[protein] => hexadecanoyl-CoA + L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45087", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863463", "l": "STON2 binds SYT proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873926", "l": "IFNG dimer binds IFNGR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362437", "l": "C-terminal Hh fragments are bound by lectins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44892", "l": "an N-(2-hydroxyacyl)-sphinganine + UDP-alpha-D-galactose = an N-(2-hydroxyacyl)-beta-D-galactosyl-sphinganine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52965", "l": "hyodeoxycholate + UDP-alpha-D-glucuronate => H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177690", "l": "Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624954", "l": "INPP5E translocates to the primary cilium (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17723", "l": "a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0008942", "l": "nitrite reductase [NAD(P)H] activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10363", "l": "3,4-dihydrocoumarin + H2O <=> 3-(2-hydroxyphenyl)propanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25999", "l": "H2O + N(1)-acetylspermine + O2 <=> H2O2 + N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20001", "l": "glycolaldehyde + H2O + NAD(+) = glycolate + 2 H(+) + NADH"}, {"i": "EC:1.2.1.21", "l": "\"Glycolaldehyde dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68615", "l": "Formation of ORC(1-6) complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627369", "l": "SEPT4 binds XIAP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2314678", "l": "Aspirin acetylates PTGS1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12388", "l": "formononetin + O2 + reduced [NADPH--hemoprotein reductase] = 2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961907", "l": "E2F1 binds the CDC45 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-947499", "l": "Exchange of oxygen with sulfur in MoCo (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51624", "l": "formate + GTP + H(+) = CO2 + dGTP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63014", "l": "diphosphate + ilicicolinate B => (2E,6E)-farnesyl diphosphate + orsellinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52421", "l": "O-phospho-L-serine + thiosulfate => phosphate + S-sulfo-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2245218", "l": "CDK1 phosphorylates PHF8 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46200", "l": "5alpha-androstane-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] = 5alpha-androstane-3beta,6alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.-.-.-", "l": "\"Translocases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848829", "l": "CBL autoubiquitinates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42960", "l": "H(+) + NAD(+) + 2 reduced [nitric oxide reductase rubredoxin domain] = NADH + 2 oxidized [nitric oxide reductase rubredoxin domain]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-921155", "l": "p-STAT5 dissociates from the receptor complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445700", "l": "Myosin Binds ATP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603062", "l": "Complexed PIWIL2 binds  pre-piRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199093", "l": "CXADR binds to AMICA1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56691", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 <=> (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010521", "l": "telomerase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33589", "l": "CoA + H(+) + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate => acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50153", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39099", "l": "3-oxodecanedioyl-CoA + CoA = acetyl-CoA + octanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23903", "l": "cis-stilbene oxide + H2O <=> (1R,2R)-hydrobenzoin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446372", "l": "Association of  PARVA with TESK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018774", "l": "RHOBTB1 binds GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27795", "l": "(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate => all-trans-heptaprenyl diphosphate + 4 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27541", "l": "ethanol + N,N-dimethyl-4-nitrosoaniline <=> 4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156678", "l": "Activation of Cdc25C (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24479", "l": "H2O + maleimide <=> H(+) + maleamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50167", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198756", "l": "ERK1/2 phosphorylates MSK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857686", "l": "FITM1, FITM2 bind TAGs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41705", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O => 1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52326", "l": "5 H(+) + 4 H2O + 2 L-citrulline + 2 nitric oxide + 3 oxidized [flavodoxin] => 2 L-arginine + 4 O2 + 3 reduced [flavodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33711", "l": "4-sulfomuconolactone + H2O = 2 H(+) + maleylacetate + sulfite"}, {"i": "EC:3.1.1.92", "l": "\"4-sulfomuconolactone hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64466", "l": "H(+) + H2O2 + L-topaquinyl-[protein] => L-tyrosyl-[protein] + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24735", "l": "2-oxoglutarate + 4-hydroxybutanoate => (R)-2-hydroxyglutarate + succinate semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69173", "l": "Joining of adjacent Okazaki fragments (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25910", "l": "an aldose + H2O2 => an alditol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65250", "l": "6-hydroxymellein + A + 5 CO2 + 5 CoA + H2O => AH2 + 5 H(+) + 5 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35066", "l": "H2O + pyrazinamide <=> NH4(+) + pyrazine-2-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5227009", "l": "ABCF1 binds EIF2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24086", "l": "all-trans-antheraxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => all-trans-zeaxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44277", "l": "eicosanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(2-oxohenicosyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36478", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA <=> (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32365", "l": "H(+) + H2O2 + L-ascorbate => L-gulono-1,4-lactone + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010231", "l": "ROBO1 binds FLRT3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60800", "l": "2-oxoglutarate + gibberellin A53 + O2 = CO2 + gibberellin A44 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977371", "l": "Factor I inactivates Factor H-boundC3b (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38022", "l": "(9Z)-octadecenoyl-CoA + 1-decanoylglycerol <=> 1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141310", "l": "FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50039", "l": "choloyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + choloyl-4'-phosphopantetheine + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163798", "l": "Furin cleaves pro-protein Z to protein Z (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376141", "l": "Interaction of ABL with ROBO1:SLIT2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0140223", "l": "general transcription initiation factor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66899", "l": "4 O2 + ophiobolin F + 4 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 6 H2O + ophiobolin C + 4 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662621", "l": "MT1M binds zinc (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26231", "l": "geranylgeranyl diphosphate + 3 H(+) + 3 NADPH => 3 NADP(+) + phytyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46253", "l": "2 [Fe(II)-cytochrome b5] + a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.43"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59263", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) + H2O <=> Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66408", "l": "ATP + glutathione(in) + glycochenodeoxycholate(in) + H2O = ADP + glutathione(out) + glycochenodeoxycholate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218836", "l": "PTK2beta binds alphaVbeta3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445083", "l": "CHL1 interacts with NRP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20094", "l": "an anthocyanidin + H(+) + UDP-alpha-D-glucose => an anthocyanidin 3-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353226", "l": "Association of Ku heterodimer with ends of DNA double-strand breaks (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373747", "l": "Phosphorylation of nephrin by FYN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49465", "l": "2,6-dihydroxybenzoate + H(+) => CO2 + resorcinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371590", "l": "HSP70 binds to HSP40:nascent protein (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52565", "l": "2-dehydro-L-erythronate => 3-dehydro-L-erythronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647978", "l": "pro-RAS proteins are farnesylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050061", "l": "long-chain-aldehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9611851", "l": "ADRB2 bind ADR,NAd (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183126", "l": "Factor B binds to surface-associated C3b (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551571", "l": "WNT5A binds ROR2 and VANGL2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480204", "l": "POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247849", "l": "WLS dissociates from retromer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690152", "l": "USP5 cleaves polyubiquitin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0097493", "l": "structural molecule activity conferring elasticity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849055", "l": "PTK6 binds ARHGAP35 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417820", "l": "P2Y9 receptor can bind to LPA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989770", "l": "Expression of PLIN2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50417", "l": "L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] => H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061923", "l": "(2S,3R,6S,9S)-(-)-protoillud-7-ene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798474", "l": "S100A8:S100A9 binds Zn2+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41315", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-168136", "l": "Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004774", "l": "succinate-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983147", "l": "Release of E3 from polyubiquitinated substrate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53130", "l": "epsilon-carotene => delta-carotene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8863463", "l": "STON2 binds SYT proteins (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901149", "l": "salicylic acid binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46367", "l": "2 [Fe(II)-cytochrome b5] + an N-acylsphinganine + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + an N-acyl-(4R)-4-hydroxysphinganine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211191", "l": "Association of DFF with alpha:beta importin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18037", "l": "agmatine + H2O = N-carbamoylputrescine + NH4(+)"}, {"i": "EC:3.5.3.12", "l": "\"Agmatine deiminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102170", "l": "5-epi-aristolochene-1,3-dihydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32005", "l": "diphosphate + isopimara-8(14),15-diene => (+)-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.11"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23080", "l": "L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O"}, {"i": "EC:4.2.1.90", "l": "\"L-rhamnonate dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19673", "l": "1,2,3-trihydroxybenzene + O2 = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+)"}, {"i": "EC:1.13.11.35", "l": "\"Pyrogallol 1,2-oxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004080", "l": "biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-376419", "l": "Formation of NR-MED1 Coactivator Complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46119", "l": "2-dehydro-3-deoxy-D-galactonate <=> D-glyceraldehyde + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24825", "l": "dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048000", "l": "isoflavone 3'-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322434", "l": "XIAP dissociates from ub-TLE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37277", "l": "L-alanine + L-glutamine => H2O + L-alanyl-L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218824", "l": "p-6Y-VEGFR2 binds FYN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938108", "l": "SERPINB13 binds cathepsin L (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050311", "l": "sulfite reductase (ferredoxin) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15818", "l": "H2O + O2 + pyridoxamine 5'-phosphate => H2O2 + NH4(+) + pyridoxal 5'-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45289", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2 => 2-glyceryl-prostaglandin G2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051699", "l": "proline oxidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071933", "l": "Arp2/3 complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36170", "l": "a 2'-deoxyribonucleoside 5'-phosphate + H2O <=> a 2'-deoxyribonucleoside + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48301", "l": "H2O + prostaglandin F2alpha 1-glyceryl ester => glycerol + H(+) + prostaglandin F2alpha"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29495", "l": "(2E,6E)-farnesyl diphosphate + H2O = beta-eudesmol + diphosphate"}, {"i": "EC:4.2.3.68", "l": "\"Beta-eudesmol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66356", "l": "(5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + NAD(+) = (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24017", "l": "16-epivellosimine + acetyl-CoA => CoA + vinorine"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0010854", "l": "adenylate cyclase regulator activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047674", "l": "apiose 1-reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18058", "l": "O2 + Watasenia luciferin => CO2 + hnu + oxidized Watasenia luciferin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3222237", "l": "SMYD2 methylates TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983156", "l": "Polyubiquitination of substrate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018585", "l": "fluorene oxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14278", "l": "(S)-lactaldehyde + H2O + NAD(+) => (S)-lactate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55552", "l": "N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849906", "l": "SALM1 binds NMDA receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43676", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033730", "l": "arogenate dehydrogenase (NADP+) activity"}, {"i": "MetaCyc:1.3.1.78-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.151", "l": "\"Xyloglucan-specific endo-beta-1,4-glucanase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46670", "l": "5beta-dihydrodeoxycorticosterone + NADP(+) => 21-hydroxyprogesterone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19704", "l": "a flavonol 3-O-glycoside + UDP-alpha-D-xylose <=> a flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11512", "l": "salicyl alcohol + UDP-alpha-D-glucose = H(+) + salicin + UDP"}, {"i": "EC:2.4.1.172", "l": "\"Salicyl-alcohol beta-D-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20983", "l": "2 bilirubin IXalpha + O2 <=> 2 biliverdin IXalpha + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5631885", "l": "PRDX1 overoxidizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690702", "l": "LYN phosphorylates CD22 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375138", "l": "CDO binds BOC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16180", "l": "H2O + NAD(+) + retinal <=> 2 H(+) + NADH + retinoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52653", "l": "lanosterol + S-adenosyl-L-methionine => 24-methylene-24-dihydrolanosterol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70494", "l": "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445714", "l": "Aquaporin-3 passively transports water out of cell (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62440", "l": "[(1->4)-alpha-D-galacturonosyl methyl ester](n) = 4-deoxy-6-O-methyl-L-threo-hex-4-enopyranuronate + [(1->4)-alpha-D-galacturonosyl methyl ester](n-1)"}, {"i": "EC:4.2.2.27", "l": "\"Pectin monosaccharide-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018542", "l": "NOTCH3 coactivator complex binds DLGAP5 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651789", "l": "LIG1 bound to POLB ligates SSB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033094", "l": "butane-1,4-diamine:2-oxoglutarate aminotransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008835", "l": "diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"}, {"i": "MetaCyc:RIBOFLAVINSYNDEAM-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58484", "l": "H2O + N-(acetyl)-sphing-4-enine = acetate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672083", "l": "KTN1 binds Kinesin-1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000433", "l": "SUMOylation of PML with SUMO3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17416", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> an N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350901", "l": "Iodide is organified (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448963", "l": "Interaction of MyoD:E protein with MEF2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52135", "l": "adenosine-5'-diphospho-5'-(ribonucleotide)-(DNA) + H2O <=> 5'-phospho-(ribonucleotide)-(DNA) + AMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381727", "l": "RAP1A exchanges GDP for GTP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2569057", "l": "RIP3 binds TRIF to mediate necroptosis (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30062", "l": "(S)-dihydroorotate + fumarate <=> orotate + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39235", "l": "(3R)-hydroxytriacontanoyl-CoA = (2E)-triacontenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351208", "l": "Spermidine  => N-acetylated spermidine (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5333671", "l": "CLCAs self cleave (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9607301", "l": "Active FLT3:GRB2 binds SOS1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987120", "l": "JAK1 binds IFNLR1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27927", "l": "UMP(in) => UMP(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424486", "l": "Phosphorylation and activation of VAV2/VAV3 by SYK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654625", "l": "Activated FGFR3 binds SHC1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60826", "l": "2 AMP + 2 H(+) => H2O + P(1),P(2)-bis(5'-adenosyl) diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189069", "l": "sucrose + H2O => glucose + fructose (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30719", "l": "acetyl-CoA + propanoyl-CoA = 2-methyl-3-oxobutanoyl-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50232", "l": "8 H(+) + heme b + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = biliverdin IXalpha + CO + Fe(2+) + 3 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.15.20", "l": "\"Heme oxygenase (biliverdin-producing, ferredoxin)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32233", "l": "ADP + H(+) + NADPH + phosphate => (6S)-NADPHX + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5683774", "l": "p-T68-CHEK2 dimerizes (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050191", "l": "phosphoglycerate kinase (GTP) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42644", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[malonate decarboxylase ACP] = diphosphate + holo-[malonate decarboxylase ACP]"}, {"i": "EC:2.7.7.66", "l": "\"Malonate decarboxylase holo-[acyl-carrier protein] synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008866", "l": "fructuronate reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382055", "l": "Grb7 binds to the active PDGF receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465941", "l": "A REH hydrolyses 11cRE to 11cROL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40255", "l": "(2E)-hexadecenedioyl-CoA + H2O = (3R)-hydroxyhexadecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664871", "l": "NBR1 translocates from cytosol to perixosomal membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36213", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + phosphate => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607734", "l": "PKC-delta translocates to plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797100", "l": "CCNK binds CDK13 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17214", "l": "UDP-N-acetyl-alpha-D-glucosamine => UDP-N-acetyl-alpha-D-mannosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9035484", "l": "CysS248-MPST:TXN2 dissociates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63828", "l": "L-alanine + vanillin = pyruvate + vanillylamine"}, {"i": "EC:2.6.1.119", "l": "\"Vanillin aminotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791016", "l": "SFTPB binds itself (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909776", "l": "beta-alanine + pyruvate => 3-oxopropanoate + alanine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3065958", "l": "An unknown protease degrades ACACA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22198", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + A + 2 H2O => (9Z,12Z)-octadecadienoyl-CoA + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168374", "l": "RasGRP1 and RasGRP3 binds diacylglycerol and is phosphorylated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25152", "l": "2-oxoglutarate + L-phenylalanine = 3-phenylpyruvate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165033", "l": "Multimerization of Rev (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34001", "l": "5alpha-cholesta-7,24-dien-3beta-ol => 5alpha-cholesta-8,24-dien-3beta-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018815", "l": "3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity"}, {"i": "MetaCyc:RXN-645"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30885", "l": "D-glucarate + 3 H(+) + NADH => D-glucurono-3,6-lactone + 2 H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39334", "l": "(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H(+) + NADPH <=> (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50944", "l": "3-phenylpropanoate + NAD(+) = (E)-cinnamate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30541", "l": "(S)-carnitinyl-CoA => (R)-carnitinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678925", "l": "NR3C1 binds NR3C1 agonists (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31540", "l": "(2S)-naringenin + S-adenosyl-L-methionine => (2S)-sakuranetin + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21256", "l": "3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate"}, {"i": "EC:2.5.1.19", "l": "\"3-phosphoshikimate 1-carboxyvinyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218804", "l": "p38 MAPK activation by VEGFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14519", "l": "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA => (E)-feruloyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102166", "l": "[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity"}, {"i": "RHEA:48892", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O = L-threonyl-[protein] + N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981539", "l": "C3b binds to cell surface (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450027", "l": "Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0030283", "l": "testosterone dehydrogenase [NAD(P)] activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158849", "l": "Phenol can form a sulfate conjugate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60124", "l": "pre-sodorifen diphosphate = diphosphate + sodorifen"}, {"i": "EC:4.2.3.205", "l": "\"Sodorifen synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102140", "l": "heparan sulfate N-deacetylase activity"}, {"i": "MetaCyc:RXN-11557"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173542", "l": "SMURF2 ubiquitinates SMAD2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654425", "l": "Activated FGFR4 binds SHC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50550", "l": "H2O + prostaglandin A1 => prostaglandin E1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40002", "l": "a sphingoid 1-phosphate <=> a fatty aldehyde + phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59146", "l": "5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate => 10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019869", "l": "chloride channel inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57712", "l": "(E)-sinapoaldehyde + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-4-trans-sinapoyl aldehyde + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43733", "l": "a triacyl-sn-glycerol + H2O => 1,3-diacyl-sn-glycerol + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987214", "l": "p-STAT3 dimerizes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668597", "l": "DNA polymerase:primase binds G-strand of the telomere (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56224", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-449117", "l": "TXLNA (IL14) binds syntaxin1A (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419011", "l": "Transhomodimerization of Nectins (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50903", "l": "10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O <=> (10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52422", "l": "phosphate + S-sulfo-L-cysteine => O-phospho-L-serine + thiosulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50248", "l": "ATP + D-ribose 5-phosphate + H(+) = ADP-D-ribose + diphosphate"}, {"i": "EC:2.7.7.96", "l": "\"ADP-D-ribose pyrophosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66563", "l": "(R)-noradrenaline + L-glutaminyl-[protein] <=> 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013145", "l": "RAC1 binds effectors at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008096", "l": "juvenile hormone epoxide hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24292", "l": "acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate"}, {"i": "EC:2.3.1.1", "l": "\"Amino-acid N-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30742", "l": "1D-myo-inositol 3-phosphate + H2O <=> myo-inositol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802941", "l": "RAF is paradoxically phosphorylated downstream of kinase-inactive RAF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805638", "l": "KAT6A acetylates TP53 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47747", "l": "demethylphylloquinone + H(+) + NADPH <=> demethylphylloquinol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213239", "l": "Formation of MHC II alpha beta heterodimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944236", "l": "Association of procollagen type XIV (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62116", "l": "H2O + iminosuccinate = NH4(+) + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804276", "l": "ATM phosphorylates TTC5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2160851", "l": "HAS1,2,3 mediate the polymerisation of HA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0060229", "l": "lipase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49345", "l": "2-hydroxyspirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2,2-dihydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.2.-", "l": "\"Ether hydrolases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25488", "l": "(2E)-geranyl diphosphate = (1S,5S)-alpha-pinene + diphosphate"}, {"i": "EC:4.2.3.119", "l": "\"(-)-alpha-pinene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48273", "l": "2-methylhexanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => 2-methylhexenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56586", "l": "propane-1,2-diol => 1,2-epoxypropane + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64068", "l": "(R)-phenylacetylcarbinol + NAD(+) = 1-phenyl-1,2-propanedione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43250", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + phosphate => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936615", "l": "acetylation of serine (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25926", "l": "8-hydroxyquinolin-2(1H)-one + AH2 => A + H2O + quinolin-8-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56293", "l": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] => 4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362522", "l": "ALDHs oxidise atRAL to atRA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "79.682896251205548", "identifiers": [{"i": "GO:0016891", "l": "endoribonuclease activity, producing 5'-phosphomonoesters"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451283", "l": "kainate receptor binds glutamate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38604", "l": "NADP(+) => 2'-phospho-cyclic ADP-ribose + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16286", "l": "D-octopine + H2O + NAD(+) => H(+) + L-arginine + NADH + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42993", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (R)-nephthenol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433981", "l": "Auto ubiquitination of the TRAF6 within the complex viral dsRNA:TLR3:TICAM1:TRAF6 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9633008", "l": "p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201717", "l": "CSNK2-mediated phosphorylation of DVL (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371554", "l": "HSF1 acetylation at Lys80 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-975040", "l": "KRAB-ZNF / KAP Interaction (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47916", "l": "ATP + N-hexanoyl-(4R)-hydroxysphinganine = ADP + H(+) + N-hexanoyl-(4R)-hydroxysphinganine-1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944247", "l": "Association of procollagen type VI (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6790454", "l": "SUMOylation of XPC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448958", "l": "Nuclear translocation of p38 MAPK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021357", "l": "PRKCI phosphorylates ELF3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42844", "l": "6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH = 7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide"}, {"i": "EC:2.3.1.240", "l": "\"Narbonolide synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20856", "l": "an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine"}, {"i": "EC:3.5.1.23", "l": "\"Ceramidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14862", "l": "(S)-dihydroorotate + NADP(+) => H(+) + NADPH + orotate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102933", "l": "GDP-4-dehydro-6-deoxy-D-mannose-4-aminotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33116", "l": "malonate(in) => malonate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25730", "l": "N-hydroxy-L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44319", "l": "1-dodecanoylglycerol + H2O <=> dodecanoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39355", "l": "(2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H(+) + NADPH = (11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045513", "l": "interleukin-27 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38261", "l": "glyoxylate + propanoyl-CoA => (2R,3S)-beta-methylmalyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805061", "l": "CK2 binds FACT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24530", "l": "H(+) + methylglyoxal + NADH => (R)-lactaldehyde + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375161", "l": "NCAM1 trans-homophilic interaction (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62560", "l": "(4R)-limonene + A + H2O = (4R)-perillyl alcohol + AH2"}, {"i": "RHEA:62564", "l": "(4S)-limonene + A + H2O = (4S)-perillyl alcohol + AH2"}, {"i": "EC:1.17.99.8", "l": "\"Limonene dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41677", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + ATP => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33498", "l": "all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate <=> 3-heptaprenyl-sn-glycero-1-phosphate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610732", "l": "GSK3 phosphorylates p-GLI3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12674", "l": "an aliphatic amide => a nitrile + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54634", "l": "2-hydroxytetradecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + O2 + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707523", "l": "Hemes bind to BACH1:MAFK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36813", "l": "CoA + GDP-N-acetyl-alpha-D-perosamine + H(+) => acetyl-CoA + GDP-alpha-D-perosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18156", "l": "2 GTP + H(+) <=> diphosphate + P(1),P(4)-bis(5'-guanosyl) tetraphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21066", "l": "[protein]-dithiol + glutathione disulfide => [protein]-disulfide + 2 glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63113", "l": "A + ascofuranol => AH2 + ascofuranone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938938", "l": "RUNX1 and ELF1 bind the IL3 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052833", "l": "inositol monophosphate 4-phosphatase activity"}, {"i": "MetaCyc:RXN-10952"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592314", "l": "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696547", "l": "STAMBPL1 is a deubiquitinase (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26404", "l": "all-trans-10'-apo-beta-carotenal + O2 <=> (2E,4E,6E)-4-methylocta-2,4,6-trienedial + 13-apo-beta-carotenone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69140", "l": "RPA binds to the Flap (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201515", "l": "Active ALK recruits PI3K (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21023", "l": "5-O-(1-carboxyvinyl)-3-phosphoshikimate <=> chorismate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57039", "l": "[(1->6)-alpha-D-glucosyl](n) + sucrose <=> (1->3)-alpha-D-glucosyl-[(1->6)-alpha-D-glucosyl]n + D-fructose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36025", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2484822", "l": "Kinetochore assembly (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16741", "l": "a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12892", "l": "L-gulonate + NAD(+) <=> 3-dehydro-L-gulonate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13449", "l": "2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40860", "l": "(9Z)-hexadecenoyl-CoA + FAD + H(+) => (2E,9Z)-hexadecadienoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42656", "l": "diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + H(+) + methanol"}, {"i": "EC:3.1.1.97", "l": "\"Methylated diphthine methylhydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31076", "l": "(3S)-3-hydroxydodecanoyl-CoA => (2E)-dodecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63365", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + O2 => (S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-1,3-oxazole-[protein] + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19588", "l": "lithocholate + NAD(+) <=> 3-oxo-5beta-cholan-24-oate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130619", "l": "TGN-lysosomal vesicle coat assembly (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48877", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O => L-seryl-[protein] + N-acetyl-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34194", "l": "(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O <=> (2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25271", "l": "(R)-adrenaline + H(+) + S-adenosyl-L-homocysteine => (R)-noradrenaline + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37881", "l": "aklaviketone => methyl aklanonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17756", "l": "S-(5-deoxy-D-ribos-5-yl)-L-homocysteine <=> (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450063", "l": "Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102861", "l": "1-18:2-2-18:1-phosphatidylcholine desaturase activity (SN2-18:2 forming)"}, {"i": "MetaCyc:RXN-8328"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692785", "l": "p-S215 FOXO1 binds RAG gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17363", "l": "H(+) + malonate + urea => 3-oxo-3-ureidopropanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210274", "l": "SIRP beta binds TYROBP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24332", "l": "3alpha-hydroxy-3,5-dihydromonacolin L carboxylate = H2O + monacolin L carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12292", "l": "ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15707", "l": "2 a ubiquinol + phenylglyoxylyl-CoA => 2 a ubiquinone + H2O + phenylacetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162657", "l": "Inactivation of Myt1 kinase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28787", "l": "4-hydroxy-L-threonine + ATP = 4-(phosphooxy)-L-threonine + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34911", "l": "D-methionine(in) = D-methionine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5653974", "l": "Ragulator binds Rag dimers (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950778", "l": "p-Y693-STAT4 dimerizes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52406", "l": "CO2 + dihydroxyacetone phosphate => 3-dehydro-4-O-phospho-L-erythronate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3076905", "l": "Extracellular BTD hydrolyses BCTN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33902", "l": "FAD + H(+) + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose <=> FADH2 + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11303", "l": "1D-5-O-methyl-myo-inositol + NAD(+) <=> 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617462", "l": "HOXD1 gene is transcribed (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53299", "l": "(2E)-decenoyl-CoA + NADP(+) <=> (2E,4E)-decadienoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21925", "l": "3-dehydro-L-gulonate + NAD(+) => 2,3-dioxo-L-gulonate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983426", "l": "Capturing cargo and formation of prebudding complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64636", "l": "benzoyl-CoA + butan-1-ol = butyl benzoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66895", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29047", "l": "a menaquinone + 2 H(+)(in) + H2 = a menaquinol + 2 H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0008381", "l": "mechanosensitive ion channel activity"}, {"i": "TCDB:1.A.23.2.1"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008419", "l": "RNA lariat debranching enzyme activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434027", "l": "Dimerization of Phospho-IRF3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10829", "l": "anthranilate + ATP + CoA => AMP + anthraniloyl-CoA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400143", "l": "Fatty acid ligands activate PPARA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31130", "l": "3-O-methylgallate + O2 <=> 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.28", "l": "\"L-cysteine desulfidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140665", "l": "ATP-dependent H3-H4 histone complex loader activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62762", "l": "4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803063", "l": "RNASEs bind bacterial LPS, PGN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42588", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41031", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + decanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-decanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928619", "l": "PAK1 binds RAC1:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624125", "l": "Formation of the BBSome (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0008391", "l": "arachidonic acid monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928641", "l": "PAK binds RAC and bPIX (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448629", "l": "IL33 binds IL1RL1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33726", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-tetracosanoylsphinganine <=> a 1,2-diacyl-sn-glycerol + N-tetracosanoylsphinganine-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785213", "l": "LIPC dimer binds heparin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090591", "l": "protein-N(PI)-phosphohistidine-N-acetyl-mannosamine phosphotransferase system transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53404", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 13-hydroxy-(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981657", "l": "IL34 dimer binds PTPRZ1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693609", "l": "ATM phosphorylates TP53 at S15 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45015", "l": "H2O + N-octadecanoyl-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65889", "l": "2-oxoglutarate + 3-hydroxy-L-kynurenine => 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54992", "l": "3 A + FMN + H2O + L-glutamate + O2 = 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 3 AH2 + CO2 + H(+)"}, {"i": "EC:2.6.1.114", "l": "\"8-demethyl-8-aminoriboflavin-5'-phosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54597", "l": "2-oxoglutarate + hexadecanoyl-CoA + O2 => 2-hydroxyhexadecanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58379", "l": "decan-1-ol + NADP(+) <=> decanal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66026", "l": "[collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O => hypobromite + L-lysyl-[collagen] + L-methionyl-[collagen]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37847", "l": "13-dihydrodaunorubicin + H(+) + NADPH + O2 = daunorubicin + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006422", "l": "IFNG gene expression is stimulated by RUNX1 and inhibited by FOXP3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41872", "l": "3-oxododecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxydodecanoyl-[ACP] + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44791", "l": "2-demethylmenaquinol-11 + S-adenosyl-L-methionine <=> H(+) + menaquinol-11 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3965446", "l": "WNT5A and WNT11 bind FZD receptors to initiate Ca2+ signaling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27422", "l": "(2E,6E)-farnesyl diphosphate => (3E,6E)-alpha-farnesene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800798", "l": "The PIDDosome binds CASP2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093330", "l": "EPHB binds p120-RasGAP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60125", "l": "pre-sodorifen diphosphate => diphosphate + sodorifen"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391152", "l": "p-4Y-SIRPA:CD47 binds PTK2B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35658", "l": "2 ATP <=> 3',3'-c-di-AMP + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35219", "l": "8-oxo-dADP + H2O = 8-oxo-dAMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389381", "l": "Gads binds CD28 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981539", "l": "C3b binds to cell surface (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39489", "l": "(2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H2O => (3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176318", "l": "Loading of claspin onto DNA during replication origin firing (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850831", "l": "KLK5 cleaves and activates KLK8 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0047225", "l": "acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692768", "l": "MAPKAPK5 phosphorylates KALRN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22070", "l": "(2S)-2-acetolactate + H(+) + NADPH => (2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25608", "l": "2-(5-methylsulfanyl)oxopentanoate + acetyl-CoA + H2O <=> 2-(3-methylsulfanyl)propylmalate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176700", "l": "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784204", "l": "JAKs bind OSMR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34522", "l": "N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + 3 UDP-N-acetyl-alpha-D-galactosamine <=> [alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + 3 H(+) + 3 UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73797", "l": "FAICAR => IMP + H2O (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-171106", "l": "LDLR:LDL complex => LDLR + LDL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49723", "l": "2 H(+) + NADH + 2 O2 + protoviolaceinate <=> CO2 + 2 H2O + NAD(+) + violacein"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11791", "l": "H2O + L-aspartate + NAD(+) <=> H(+) + NADH + NH4(+) + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10146", "l": "a ribonucleoside + phosphate => a ribonucleoside 3'-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40341", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62232", "l": "a thymidine(6-4)thymidine in DNA = a thymidine dimer in DNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61248", "l": "H2O + L-tyrosine + O2 = 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004503", "l": "tyrosinase activity"}, {"i": "MetaCyc:MONOPHENOL-MONOOXYGENASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0032129", "l": "histone deacetylase activity (H3-K9 specific)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015049", "l": "methane monooxygenase activity"}, {"i": "MetaCyc:METHANE-MONOOXYGENASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372449", "l": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071860", "l": "proctolin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57861", "l": "(E)-6-hydroxyferuloyl-CoA => CoA + scopoletin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50697", "l": "calciol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => calcidiol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106276", "l": "biliberdin reductase NAD+ activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399711", "l": "Activation of Ca impermeable AMPA receptors (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50078", "l": "19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.18"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654651", "l": "Activated FGFR4 binds FRS3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.3", "l": "\"Protein-synthesizing GTPase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40304", "l": "A + dodecanedioyl-CoA => (2E)-dodecenedioyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36887", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + AH2 + O2 = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158340", "l": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865107", "l": "MICAL1 produces NADP+, H2O2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53859", "l": "NADP(+) + ursocholate <=> 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0015232", "l": "heme transmembrane transporter activity"}, {"i": "REACT:R-HSA-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170986", "l": "Ral-GDS binds to Ras-GTP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189488", "l": "UROS transforms HMB to URO3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21509", "l": "all-trans-retinyl hexadecanoate + H2O => H(+) + hexadecanoate + retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15298", "l": "3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose => 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.104", "l": "\"5-phospho-D-xylono-1,4-lactonase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51922", "l": "A + a quinol => a quinone + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48713", "l": "2 Fe(2+) + 2 H(+) + H2O2 => 2 Fe(3+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044325", "l": "transmembrane transporter binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851842", "l": "MUC20 binds MET and inhibits GRB2 binding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63912", "l": "6-azauridine + ATP = 6-azauridine 5'-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050245", "l": "quercitrinase activity"}, {"i": "KEGG.REACTION:R02436"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371435", "l": "Constitutive phosphorylation by GSK3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.196", "l": "\"L-ornithine N(5)-monooxygenase (NAD(P)H)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16756", "l": "Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADPH + O2 <=> 3,8-divinyl protochlorophyllide a + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375138", "l": "CDO binds BOC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66665", "l": "ATP + coproporphyrin III(in) + H2O => ADP + coproporphyrin III(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63016", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenamide + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52099", "l": "9-octadecanoyloxy-octadecanoate + H2O <=> 9-hydroxy-octadecanoate + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938121", "l": "SERPINB13 binds CTSK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28133", "l": "baicalin + H2O <=> baicalein + D-glucuronate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237129", "l": "Acireductone is created (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198440", "l": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021480", "l": "NOTCH3 coactivator complex binds WWC1 (Kibra) gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1878002", "l": "XYLTs transfer Xyl to core protein (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018505", "l": "Estrogen-responsive EBAG9 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953037", "l": "E2F8 forms homodimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863471", "l": "LDLR is bound by DAB2 and ARH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16220", "l": "H2O + L-arabinono-1,4-lactone <=> H(+) + L-arabinonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65194", "l": "berkeleytrione + 2 CO2 + H2O + 2 succinate => 2 2-oxoglutarate + 2 O2 + preaustinoid A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-482770", "l": "Release of platelet secretory granule components (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098695", "l": "inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.30"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.38"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65923", "l": "L-kynurenine + pyruvate <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51161", "l": "cytidine(60) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(60) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29614", "l": "H2O + NADP(+) + nitrous oxide <=> H(+) + NADPH + 2 nitric oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173542", "l": "SMURF2 ubiquitinates SMAD2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52467", "l": "17beta-estradiol + UDP-alpha-D-glucuronate <=> 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202510", "l": "Activation of TAK1-TAB2 complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58587", "l": "dihydroprecondylocarpine acetate <=> (-)-tabersonine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102811", "l": "geraniol 10-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23305", "l": "atropine + H2O => H(+) + tropate + tropine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57385", "l": "(13S,14R)-1,13-dihydroxy-N-methylcanadine + acetyl-CoA => (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.283", "l": "\"2'-acyl-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371591", "l": "Trimerization of cytosolic HSF1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693243", "l": "RHOD translocates to the Golgi membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1564112", "l": "Collagen type VI degradation by MMP2,9,11 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956684", "l": "ITCH polyubiquitinates TP73 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350651", "l": "Caspase-mediated cleavage of MASK (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445069", "l": "L1-EGFR trans-heterodimerization (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35382", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA <=> (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29381", "l": "2'-deoxyguanosine + phosphate => dGMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65178", "l": "AH2 + protoaustinoid B => A + protoaustinoid A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34786", "l": "a 3alpha-hydroxysteroid + NADP(+) <=> a 3-oxosteroid + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24265", "l": "D-xylulose 5-phosphate + formaldehyde => D-glyceraldehyde 3-phosphate + dihydroxyacetone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47335", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58111", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] <=> acetate + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37134", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38581", "l": "(20S)-protopanaxadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dammarenediol-II + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44429", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + glycerol => a 1-acyl-sn-glycero-3-phosphocholine + a 1-acylglycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782224", "l": "3' incision by ERCC5 (XPG) in TC-NER (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671772", "l": "p-T38-PPP1R14A binds MLCP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36985", "l": "3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + CO2 + CoA => (14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20257", "l": "3-methyloxindole + NADP(+) = 3-methyleneoxindole + H(+) + NADPH"}, {"i": "EC:1.3.1.17", "l": "\"3-methyleneoxindole reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51836", "l": "(9Z)-tetradecenoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z)-tetradecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165027", "l": "Rev molecules assemble onto the RRE RNA sequence through their ARM sequence (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49816", "l": "3 [Fe(III)cytochrome c] + H2O + hydrazine = 3 [Fe(II)cytochrome c] + 2 H(+) + NH4(+) + nitric oxide"}, {"i": "EC:1.7.2.7", "l": "\"Hydrazine synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018687", "l": "biphenyl 2,3-dioxygenase activity"}, {"i": "MetaCyc:1.14.12.18-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693561", "l": "RAD51 binds BRCA2 at resected DNA DSBs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8953398", "l": "PIR oxygenates quercetin (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043816", "l": "phosphoserine-tRNA(Cys) ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18345", "l": "a cis-3-alkyl-4-alkyloxetan-2-one = a cis-alkene + CO2"}, {"i": "EC:4.1.1.114", "l": "\"Cis-3-alkyl-4-alkyloxetan-2-one decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39875", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol = a 1-acyl-sn-glycero-3-phosphocholine + a 2,3-diacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57233", "l": "GDP + methylglyoxal => N(2)-(1-hydroxy-2-oxopropyl)-GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41635", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phospho-L-serine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878117", "l": "RUNX3 binds ZFHX3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019145", "l": "aminobutyraldehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9692880", "l": "HRH3 binds Hist (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39527", "l": "(2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH = (17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052929", "l": "ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610732", "l": "GSK3 phosphorylates p-GLI3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106073", "l": "dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity"}, {"i": "RHEA:29543", "l": "alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate = alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}, {"i": "EC:2.4.1.256", "l": "\"Dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-dolichol alpha-1,2-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213207", "l": "Formation of collagen networks (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61165", "l": "kaempferol + UDP-beta-L-rhamnose => H(+) + kaempferol 3-O-alpha-L-rhamnoside + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031766", "l": "type 3 galanin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26319", "l": "3-amino-4-hydroxybenzoate + H(+) + 2 H2O + phosphate => 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9626816", "l": "PIN1 binds p-S345-NCF1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39036", "l": "an omega-hydroxy fatty acid + NAD(+) => an omega-oxo fatty acid + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31157", "l": "(4S)-4-hydroxy-L-glutamate + H(+) + NADH => (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36136", "l": "(2E)-hexadecenal + H2O + NAD(+) => (E)-hexadec-2-enoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168915", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140696", "l": "factor V -> factor Va + factor V activation peptide (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69685", "l": "CHEK2 phosphorylates TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41871", "l": "decanoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "ic": "68.661248405853954", "identifiers": [{"i": "GO:0016717", "l": "oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"}, {"i": "EC:1.14.19.-", "l": "\"With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975861", "l": "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604763", "l": "Autocatalytic activation of MMP7 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28667", "l": "H(+) + hydroxyacetone + NADH = (S)-propane-1,2-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52494", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55994", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191402", "l": "Reduction of presqualene diphosphate to form squalene (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66166", "l": "CoA + H(+) + N-butanoylserotonin => butanoyl-CoA + serotonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64953", "l": "dCDP + H2O => dCMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392748", "l": "L1 binds to AP-2 Clathrin complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51866", "l": "8-geranylesculetin + diphosphate => (2E)-geranyl diphosphate + esculetin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090632", "l": "N-glycolylneuraminic acid (Neu5Gc) cytidylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2586555", "l": "JAK2 Autophosphorylates in Response to Leptin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66667", "l": "ATP + coproporphyrin III(in) + H2O <=> ADP + coproporphyrin III(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41666", "l": "chelirubine + NADH => dihydrochelirubine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19545", "l": "H2O + sn-glycerol 3-phosphocholine = glycerol + H(+) + phosphocholine"}, {"i": "EC:3.1.4.38", "l": "\"Glycerophosphocholine cholinephosphodiesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35230", "l": "H(+)(out) + rifampicin(in) <=> H(+)(in) + rifampicin(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.21"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19540", "l": "D-mannitol 1-phosphate + H2O <=> D-mannitol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34267", "l": "acetyl-CoA + fumigaclavine B = CoA + fumigaclavine A"}, {"i": "EC:2.3.1.205", "l": "\"Fumigaclavine B O-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31202", "l": "(3S)-hydroxyoctanoyl-CoA <=> (2E)-octenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30300", "l": "2-oxoglutarate + a methylated nucleobase within DNA + O2 => a nucleobase within DNA + CO2 + formaldehyde + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17526", "l": "biuret + H2O => NH4(+) + urea-1-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35442", "l": "CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine <=> archaetidylserine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044686", "l": "cysteate synthase activity"}, {"i": "RHEA:26486", "l": "H(+) + O-phospho-L-serine + sulfite = L-cysteate + phosphate"}, {"i": "EC:2.5.1.76", "l": "\"Cysteate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17612", "l": "L-seryl-[sulfatase] + S-adenosyl-L-methionine <=> 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28007", "l": "H2O + N(alpha)-methyl-L-tryptophan + O2 => formaldehyde + H2O2 + L-tryptophan"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31789", "l": "(13R)-edaxadiene + diphosphate => H2O + tuberculosinyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938108", "l": "SERPINB13 binds cathepsin L (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852716", "l": "Thrombin, ELANE cleave C5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20632", "l": "H2O + O-phospho-L-seryl-[protein] <=> L-seryl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20979", "l": "a primary nitroalkane + H2O + O2 <=> an aldehyde + H(+) + H2O2 + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9648017", "l": "EML4 binds to microtubules (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12679", "l": "A + CO2 + formate + H(+) + H2O + hnu + oxidized Latia luciferin => AH2 + Latia luciferin + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629166", "l": "Defective NEIL1 variants do not cleave Tg (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59540", "l": "(2R)-ethylmalonyl-CoA + H(+) = butanoyl-CoA + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977605", "l": "Factor H displaces Bb (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6805640", "l": "AKT phosphorylates KAT6A (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1253343", "l": "WWOX binds ERBB4s80 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62991", "l": "dodecanamide + H2O <=> dodecanoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30716", "l": "(2E)-geraniol => (S)-linalool"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004019", "l": "adenylosuccinate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36698", "l": "dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid <=> desmethyldescarbamoylnovobiocin + dTDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35708", "l": "(2S)-versicolorone + H(+) + NADPH + O2 => (3S)-versiconol acetate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13100", "l": "a (3R)-hydroxyacyl-[ACP] <=> a (2E)-enoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25295", "l": "acetaldehyde + H2O + NAD(+) => acetate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.82", "l": "\"ADAMTS-4 endopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41606", "l": "1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2247511", "l": "STAB2:ligand is endocytosed (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110322", "l": "Formation of Pol zeta complex (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696822", "l": "AKR1B15 reduces EST17b to E1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28880", "l": "H(+)(in) + L-tryptophan(in) => H(+)(out) + L-tryptophan(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32500", "l": "(1R,5R)-sabinene + H(+) + NADPH + O2 => (1S,3R,5S)-sabinol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18339", "l": "H2O + psi-UMP => D-ribose 5-phosphate + uracil"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098851", "l": "double-stranded miRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83791", "l": "Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53884", "l": "CDP-alpha-D-glucose + D-glucose 6-phosphate = alpha,alpha-trehalose 6-phosphate + CDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63562", "l": "angiotensin II + L-histidyl-L-leucine => angiotensin I + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14051", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol => O2 + reduced [NADPH--hemoprotein reductase] + taxa-4,11-diene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798372", "l": "ATM phosphorylates DYRK2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158164", "l": "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20524", "l": "(R)-3-hydroxybutanoate + NAD(+) <=> acetoacetate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5252133", "l": "ATP6AP1 binds V-ATPase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047113", "l": "aldehyde dehydrogenase (quinone) activity"}, {"i": "RHEA:13881", "l": "a quinone + an aldehyde + H2O = a carboxylate + a quinol + H(+)"}, {"i": "EC:1.2.5.2", "l": "\"Aldehyde dehydrogenase (quinone)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.144"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442586", "l": "Activation of WASP and N-WASP by CDC42 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0072542", "l": "protein phosphatase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800490", "l": "ATM phosphorylates PIDD1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045511", "l": "interleukin-25 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66456", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48341", "l": "a medium chain fatty acid + ATP + CoA => a medium-chain fatty acyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008694", "l": "IL37, IL37(?-218) translocates from cytosol to extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.176", "l": "\"Cellulose 1,4-beta-cellobiosidase (reducing end)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18428", "l": "L-quinate + NADP(+) <=> 3-dehydroquinate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030795", "l": "methyl jasmonate methylesterase activity"}, {"i": "RHEA:13349", "l": "jasmonate + S-adenosyl-L-methionine = methyl (-)-jasmonate + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.141", "l": "\"Jasmonate O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865182", "l": "OTUD7A hydrolyses K11diUb (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33459", "l": "H(+) + NADPH + zymosterone = 5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0015038", "l": "glutathione disulfide oxidoreductase activity"}, {"i": "REACT:R-HSA-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40001", "l": "a fatty aldehyde + phosphoethanolamine => a sphingoid 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618394", "l": "ARL4C gene transcription regulated by NR1H2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592278", "l": "Autocatalytic activation of proMMP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944262", "l": "Association of procollagen type X (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706312", "l": "Active FLT3 binds to LCK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9660557", "l": "RAS:GTP binds RAL GDS proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216043", "l": "Collagen type II binds integrin alpha10beta1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40125", "l": "an omega-oxo fatty acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => an omega-hydroxy fatty acid + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139919", "l": "Translocation of BIM to mitochondria (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3364026", "l": "SET1 complex trimethylates H3K4 at the MYC gene (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54335", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416929", "l": "PTGFR binds PGF2a (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32649", "l": "erythromycin A + H(+) + S-adenosyl-L-homocysteine => erythromycin C + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607753", "l": "CARD9 oligomerizes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14898", "l": "apigenin + 3 H(+) + 2 NADPH + O2 => 2-hydroxy-2,3-dihydrogenistein + H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42162", "l": "(5Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O => (11Z,14Z)-eicosadienoyl-CoA + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051379", "l": "epinephrine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682983", "l": "ATM phosphorylates WHSC1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390912", "l": "HRH1 binds hist (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3560785", "l": "Defective PAPSS2 does not transfer PO4(2-) group from ATP to APS to form PAPS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43499", "l": "L-gulonate + NAD(+) <=> H(+) + keto-D-fructuronate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11883", "l": "(S)-6-hydroxynicotine + H2O + O2 <=> 6-hydroxypseudooxynicotine + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9656893", "l": "OPN1MW binds 11cRAL (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52660", "l": "an L-alpha-amino acid + ATP + holo-[ACP] = AMP + an L-alpha-aminoacyl-[ACP] + diphosphate"}, {"i": "EC:6.2.1.n2", "l": "\"Amino acid--[acyl-carrier-protein] ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22333", "l": "(3R)-citramalate => 2-methylmaleate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52513", "l": "a quinone + trans-4-hydroxy-L-proline => (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19215", "l": "an N-acetyl-L-cysteine-S-conjugate + CoA + H(+) => acetyl-CoA + an S-substituted L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372542", "l": "Loading of dopamine into synaptic veiscles (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047518", "l": "1-methyladenosine nucleosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21158", "l": "(R)-glycerate + phosphate => (2R)-2-phosphoglycerate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58646", "l": "(9Z,12Z,15Z)-octadecatrienamide + glyoxylate => N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24500", "l": "adenosine 5'-tetraphosphate + H2O = ATP + H(+) + phosphate"}, {"i": "EC:3.6.1.14", "l": "\"Adenosine-tetraphosphatase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050103", "l": "dextrin dextranase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18645", "l": "2 putrescine = NH4(+) + sym-homospermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50363", "l": "(R)-mandelonitrile + O2 <=> benzoyl cyanide + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647977", "l": "ICMT methylates S-Farn RAS proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2197690", "l": "Detachment of WASP/WAVE (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36237", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + CoA => 1-O-alkyl-sn-glycero-3-phosphate + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38612", "l": "NAD(+) => cyclic ADP-ribose + H(+) + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5252133", "l": "ATP6AP1 binds V-ATPase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66578", "l": "4-isopropylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 4-isopropylphenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20191", "l": "H(+) + NADH + uracil => 5,6-dihydrouracil + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12410", "l": "2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+) => L-lysine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18352", "l": "ATP + L-aspartate + tRNA(Asx) <=> AMP + diphosphate + L-aspartyl-tRNA(Asx)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163691", "l": "Phosphorylation of ChREBP at Serine 568 by AMPK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686359", "l": "SFTPs translocate from extracellular region to clathrin-coated vesicle (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34093", "l": "(S)-2-amino-6-oxohexanoate + NH4(+) + phosphate => (5R)-5-phosphooxy-L-lysine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4647594", "l": "SAHF formation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27593", "l": "(R)-pantoate + ATP + beta-alanine <=> (R)-pantothenate + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004534", "l": "5'-3' exoribonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53358", "l": "H(+) + NADPH + uridine(20b) in tRNA => 5,6-dihydrouridine(20b) in tRNA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47174", "l": "5alpha-cholest-8-en-3-one + CO2 + NADH => 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48734", "l": "[CysO sulfur-carrier protein]-C-terminal Gly-Gly + H(+) + L-cysteine => [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "74.603620314006946", "identifiers": [{"i": "GO:0016413", "l": "O-acetyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18586", "l": "D-glyceraldehyde 3-phosphate => dihydroxyacetone phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64985", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33189", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33829", "l": "vitamin D2 => ergosterol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18184", "l": "acetyl-CoA + glyoxylate + H2O <=> (S)-malate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374909", "l": "Metabolism of Noradrenaline (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102092", "l": "5-diphosphoinositol pentakisphosphate 3-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3221982", "l": "BANP binds TP53 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619376", "l": "CAMK1 binds calmodulin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869438", "l": "Dissociation of clathrin-associated proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23129", "l": "4-hydroxybutanoate + ATP + CoA => 4-hydroxybutanoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74258", "l": "XDH oxidizes xanthine to form urate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42083", "l": "all-trans-retinal + H2O + NAD(+) <=> all-trans-retinoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685156", "l": "ATR phosphorylates RPA2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17006", "l": "ATP + D-glucuronate => 1-phospho-alpha-D-glucuronate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3204318", "l": "cob(II)alamin binds to MTRR:MTR (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17766", "l": "(2R)-3-phospho-glyceroyl phosphate => (2R)-2,3-bisphosphoglycerate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429730", "l": "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31117", "l": "biotinyl-5'-AMP + diphosphate => ATP + biotin + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27419", "l": "6-hydroxynicotinate + 2 [Fe(II)cytochrome] + 2 H(+) => 2 [Fe(III)cytochrome] + H2O + nicotinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371590", "l": "HSP70 binds to HSP40:nascent protein (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10058", "l": "(2E)-butenoyl-CoA + NH4(+) => (3S)-3-aminobutanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043797", "l": "glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) activity"}, {"i": "MetaCyc:1.2.7.6-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70982", "l": "Fumarate + H2O <=> (S)-Malate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9678854", "l": "S1PR1 binds S1PR1 agonists (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429101", "l": "HMIT co-transports myo-inositol with a proton (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807565", "l": "GNLY is transferred to the phagosome (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-532603", "l": "Nephrin mediated activation of N-WASP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66757", "l": "ATP + domoate(in) + H2O => ADP + domoate(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031208", "l": "POZ domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40216", "l": "FADH2 + O2 => FAD + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445069", "l": "L1-EGFR trans-heterodimerization (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804762", "l": "TP53 forms homotetramers (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64637", "l": "benzoyl-CoA + butan-1-ol => butyl benzoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15771", "l": "adenosylcob(III)inamide phosphate + ADP + H(+) => adenosylcob(III)inamide + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38097", "l": "alpha-tocotrienol + H(+) + S-adenosyl-L-homocysteine => gamma-tocotrienol + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674018", "l": "BRAP binds RAS:GTP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38824", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0009013", "l": "succinate-semialdehyde dehydrogenase [NAD(P)+] activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45002", "l": "CoA + O-3-hydroxybutanoyl-(R)-carnitine => (R)-carnitine + 3-hydroxybutanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42470", "l": "2-oxopent-4-enoate + salicylate => 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15851", "l": "2 [Fe(II)cytochrome c] + 2 H(+) + L-dehydroascorbate => 2 [Fe(III)cytochrome c] + L-ascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392874", "l": "Dissociation of the Prostacyclin receptor:Gs complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44871", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + ethanol <=> 1,2-diacyl-sn-glycero-3-phosphoethanol + choline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27847", "l": "(2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2 => (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607722", "l": "Active NIK phosphorylates IKKA dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034571", "l": "4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013024", "l": "RHOB binds effectors at the plasma membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33479", "l": "an acyl-CoA + lanosterol = CoA + lanosteryl ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16652", "l": "(S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-3'-hydroxy-N-methylcoclaurine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37466", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202534", "l": "Ubiquitination of NEMO by TRAF6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59739", "l": "L-cysteinyl-[protein] + tetradecanoyl-CoA <=> CoA + S-tetradecanoyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482892", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57807", "l": "1-chloro-3-nitrobenzene + NADH + O2 <=> 4-chlorocatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59234", "l": "diphosphate + hydropyrenol => (2E,6E,10E)-geranylgeranyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73596", "l": "dCMP + H2O => dUMP + NH4+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008851", "l": "ethanolamine ammonia-lyase activity"}, {"i": "RHEA:15313", "l": "ethanolamine = acetaldehyde + NH4(+)"}, {"i": "EC:4.3.1.7", "l": "\"Ethanolamine ammonia-lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47795", "l": "cytidine(4447) in 28S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(4447) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55789", "l": "acetone + H(+) + NADH + O2 => H2O + hydroxyacetone + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22998", "l": "2 H2O + L-dehydroascorbate => H2O2 + L-ascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15328", "l": "an acyl-CoA + sn-glycerol 3-phosphate <=> a 1-acyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.53", "l": "\"Lytic chitin monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380294", "l": "Loss of C-Nap-1 from centrosomes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11994", "l": "H(+) + H2O2 + L-1-piperideine-6-carboxylate => L-pipecolate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61903", "l": "AH2 + betaenone C <=> A + betaenone B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755479", "l": "SUMOylation of NFKB2 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318590", "l": "Defective MMACHC does not decyanate CNCbl (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55644", "l": "ATP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] = ADP + C-terminal S-cyanate-L-cysteinyl-[HypE protein] + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29423", "l": "ATP + diphosphate = ADP + H(+) + triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939203", "l": "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34090", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + cholesterol <=> a 1-acyl-sn-glycero-3-phosphocholine + a cholesterol ester"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042164", "l": "interleukin-12 alpha subunit binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28568", "l": "6 AMP + enterobactin + 7 H(+) => 3 2,3-dihydroxybenzoyl-5'-AMP + 3 L-seryl-5'-AMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16716", "l": "H2O + S-succinylglutathione <=> glutathione + H(+) + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39664", "l": "a quinol + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) => a quinone + reduced coenzyme F420-(gamma-Glu)(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58424", "l": "(E)-hex-2-en-1-ol + NADP(+) = (E)-hex--2-enal + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018610", "l": "dibenzofuran 4,4a-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141341", "l": "SMOX-3 oxidises SPN to SPM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31958", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-dien-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11939", "l": "4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4 CO2 + 4 CoA + trans-resveratrol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665748", "l": "FMNL2 binds RHOC:GTP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39748", "l": "cholesterol(in) => cholesterol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25584", "l": "alpha-L-rhamnose = beta-L-rhamnose"}, {"i": "EC:5.1.3.32", "l": "\"L-rhamnose mutarotase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46122", "l": "4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46446", "l": "(10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O => (11Z)-hexadecenoyl-CoA + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694435", "l": "MIA2 and MIA3 load procollagen VII into COPII vesicles (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35958", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin B <=> 6-hydroxytryprostatin B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32207", "l": "(2E,4Z)-2-hydroxyhexa-2,4-dienedioate = (3Z)-2-oxohex-3-enedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41322", "l": "(9Z)-octadecenoate + 2-acetyl-sn-glycero-3-phosphocholine + H(+) => 1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34664", "l": "20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + S-adenosyl-L-methionine => 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202489", "l": "Oligomerization of Bcl10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26112", "l": "UDP-N-acetyl-alpha-D-glucosamine => H2O + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209355", "l": "Monomeric PGN binds to PGRP-LCx at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947514", "l": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13190", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O => 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984671", "l": "Chromokinesins form dimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788611", "l": "HYKK phosphorylates 5HLYS (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27715", "l": "GMP + H2O => guanosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004697", "l": "protein kinase C activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047017", "l": "prostaglandin-F synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41144", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1307802", "l": "MIA40:ERV1 (CHCHD4:GFER) oxidizes cysteine residues to cystine disulfide bonds (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53594", "l": "1-tetradecanoyl-sn-glycerol + phosphate => 1-tetradecanoyl-sn-glycerol 3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1299297", "l": "Activation of THIK (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28480", "l": "galactarate(out) => galactarate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20759", "l": "(E)-caffeoyl-CoA + D-threo-isocitrate <=> 2-[(E)-caffeoyl]-D-threo-isocitrate(3-) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59832", "l": "ATP + N(6)-(D-fructosyl)-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]"}, {"i": "EC:2.7.1.171", "l": "\"Protein-fructosamine 3-kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5323526", "l": "FRAT proteins bind GSK3beta (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64387", "l": "H2O + N-acetyl-beta-D-6-sulfogalactosaminyl-(1->4)-alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine <=> alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine + N-acetyl-D-6-sulfogalactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023456", "l": "Dimerization of FGFR1 point mutants with enhanced kinase activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869438", "l": "Dissociation of clathrin-associated proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41936", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose = a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49619", "l": "2-hydroxy-2-methylpropanal + H2O + NAD(+) <=> 2-hydroxy-2-methylpropanoate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59402", "l": "D-2-aminohexanoate => L-2-aminohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112265", "l": "thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "74.836269892493803", "identifiers": [{"i": "GO:0035250", "l": "UDP-galactosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11805", "l": "an aromatic aldehyde + H2O + NAD(+) => an aromatic carboxylate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30518", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> H(+) + S-methyl-5'-thioadenosine + thermospermine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51654", "l": "H(+) + keto-D-tagaturonate + NADH => D-mannonate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33855", "l": "an inositol-1-phosphophytoceramide + GDP-alpha-D-mannose = a mannosylinositol-1-phosphophytoceramide + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51497", "l": "a sphingoid base + ATP => a sphingoid 1-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56648", "l": "3-oxochol-4-en-24-oyl-CoA + NAD(+) = 3-oxochol-4,6-dien-24-oyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004318", "l": "enoyl-[acyl-carrier-protein] reductase (NADH) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27821", "l": "L-idonate + NAD(+) <=> 2-dehydro-L-idonate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63074", "l": "4 CO2 + 4 CoA + orcinol => acetyl-CoA + 3 H(+) + 3 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013157", "l": "CDC42 binds effectors at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15963", "l": "H(+) + taxiphyllin + UDP => 4-hydroxymandelonitrile + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30076", "l": "CMP + H2O => cytosine + D-ribose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791221", "l": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26076", "l": "H2O + UDP-alpha-D-glucuronate <=> D-glucuronate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9671145", "l": "DKC1 binds SHQ1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684282", "l": "nsp9 forms a homodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20728", "l": "H2O + L-glutamate + O2 = 2-oxoglutarate + H2O2 + NH4(+)"}, {"i": "EC:1.4.3.11", "l": "\"L-glutamate oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44959", "l": "(2E)-hexenoyl-CoA + H(+) + NADPH <=> hexanoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20849", "l": "H(+) + O2 + phosphate + pyruvate => acetyl phosphate + CO2 + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844447", "l": "NLRP1 senses MDP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51609", "l": "(R)-2-hydroxyglutarate + pyruvate => (R)-lactate + 2-oxoglutarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11159", "l": "H2O + L-valine + NADP(+) <=> 3-methyl-2-oxobutanoate + H(+) + NADPH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48111", "l": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12685", "l": "2 mycothiol + NADP(+) = H(+) + mycothione + NADPH"}, {"i": "RHEA:12689", "l": "2 mycothiol + NAD(+) = H(+) + mycothione + NADH"}, {"i": "EC:1.8.1.15", "l": "\"Mycothione reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16706", "l": "17alpha-estradiol + NADP(+) => estrone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450088", "l": "GLUT1 tetramer binds 4xATP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430308", "l": "PARVB interacts with Alpha-actinin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017154", "l": "semaphorin receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42546", "l": "pseudouridine(32) in tRNA => uridine(32) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14139", "l": "6-O-sulfo-beta-D-galactosyl-(1<->1)-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + beta-D-galactosyl-(1<->1)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48203", "l": "H(+) + oxidized [electron-transfer flavoprotein] + undecanoyl-CoA <=> reduced [electron-transfer flavoprotein] + trans-2-undecenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9668415", "l": "VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31304", "l": "a reduced flavin + NAD(+) => an oxidized flavin + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63106", "l": "16-hydroxy-ilicicolin A epoxide + H2O + NADP(+) => H(+) + ilicicolin A epoxide + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176517", "l": "SULTs transfer (SO4)2- group to PREG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935740", "l": "RUNX1 and GATA1 bind the promoter of the ITGA2B gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30930", "l": "2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnose + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195275", "l": "Phosphorylation of APC component of the destruction complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67108", "l": "L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61204", "l": "L-arginyl-[protein] + L-cysteinyl-[protein] + methylglyoxal = H(+) + 2 H2O + N(5)-[4-(S-L-cysteinyl-[protein])-5-methyl-1H-imidazol-2-yl]-L-ornithinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194796", "l": "botB LC cleaves target cell VAMP2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55540", "l": "40 ATP + 40 H2O + N2 + 12 reduced [2Fe-2S]-[ferredoxin] = 40 ADP + 26 H(+) + 3 H2 + 2 NH4(+) + 12 oxidized [2Fe-2S]-[ferredoxin] + 40 phosphate"}, {"i": "EC:1.18.6.2", "l": "\"Vanadium-dependent nitrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35307", "l": "H(+) + NADH + O2 + salicylate = 2,5-dihydroxybenzoate + H2O + NAD(+)"}, {"i": "EC:1.14.13.172", "l": "\"Salicylate 5-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015089", "l": "high-affinity copper ion transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863013", "l": "CDK5 binds p25 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55356", "l": "11-cis-retinol = 13-cis-retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32361", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+) => 1D-myo-inositol 1,4,5-trisphosphate + 2 ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204549", "l": "Caveolin-1 binds Basigin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30313", "l": "formaldehyde + H2O + NAD(+) + xanthine => 7-methylxanthine + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048185", "l": "activin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156682", "l": "PLK1 phosphorylates NUDC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032532", "l": "NTRK2-bound FYN autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47968", "l": "ganglioside GM2 + H2O = ganglioside GM3 + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12289", "l": "an alpha-L-fucoside + H2O => an alcohol + L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668481", "l": "Protesomal degradation of K48polyUb-TRAF3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45626", "l": "AMP + diphosphate + L-alloisoleucyl-[CmaA peptidyl-carrier protein] => ATP + holo-[CmaA peptidyl-carrier protein] + L-alloisoleucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58255", "l": "H2O + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] <=> ADP-D-ribose + L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62302", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine + NADP(+) => 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61191", "l": "quercetin 3-O-beta-D-glucoside + UDP-beta-L-rhamnose <=> H(+) + quercetin 3-O-beta-D-glucoside-7-O-alpha-L-rhamnoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32437", "l": "4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => dihydrocarvone + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189439", "l": "ALAD condenses 2 dALAs to form PBG (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.n1"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030564", "l": "tRNA 2'-O-ribose methylation guide activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38805", "l": "1-octadecanoyl-N-(acetyl)-sphing-4-enine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353039", "l": "1,3-bisphosphoglycerate + ADP <=> 3-phosphoglycerate + ATP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442749", "l": "CaMKK autophosphorylates in the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008841", "l": "dihydrofolate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730595", "l": "Phosphorylated STAT3 Forms Dimers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54007", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36677", "l": "CoA + H(+) + N-(octacosanoyl)-sphinganine => octacosanoyl-CoA + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60220", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(4)-[histone H3] + O2 = CO2 + formaldehyde + L-lysyl(4)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20995", "l": "16-hydroxytabersonine + S-adenosyl-L-methionine <=> 16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22789", "l": "dimethylsulfonioacetate + L-homocysteine => (methylsulfanyl)acetate + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31134", "l": "5,10-methenyltetrahydrofolate + H2O + N(1)-(5-phospho-beta-D-ribosyl)glycinamide <=> (6S)-5,6,7,8-tetrahydrofolate + 2 H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51439", "l": "acetyl-CoA + D-alanine <=> (2R)-2-amino-4-oxopentanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374919", "l": "Noradrenaline clearance from the synaptic cleft (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25845", "l": "(1S,5R)-carveol + NAD(+) => (R)-carvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56370", "l": "3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+) => 3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53437", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18816", "l": "(2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate <=> (3E,5R)-5-carboxy-2-oxohept-3-enedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653974", "l": "Ragulator binds Rag dimers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57365", "l": "H2O + NADH => (6S)-NADHX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380272", "l": "Plk1-mediated phosphorylation of Nlp (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199046", "l": "Ligands bind L-selectin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34761", "l": "ADP + glycerol 2-phosphate(in) + H(+) + phosphate => ATP + glycerol 2-phosphate(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14274", "l": "A + H2O + spermidine => 4-aminobutanal + AH2 + propane-1,3-diamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43953", "l": "3,7,11,15-tetramethylhexadecanoate + H(+) + NADPH + O2 => H2O + NADP(+) + omega-hydroxy-3,7,11,15-tetramethyl-hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56476", "l": "(5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 = (4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35189", "l": "(Z)-3-aminoacrylate + A + H(+) + H2O => (Z)-3-aminoperacrylic acid + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805479", "l": "TP53RK phosphorylates TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13606", "l": "2 L-ascorbate + O2 => 2 H2O + 2 L-dehydroascorbate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111264", "l": "Addition of nucleotides between position +11 and +30 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183052", "l": "CBL binds to GRB2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14567", "l": "3-oxo-(13Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP] => (11Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16878", "l": "3-sulfino-L-alanine + H(+) => CO2 + hypotaurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55663", "l": "2 AH2 + all-trans-beta-carotene + 2 O2 <=> 2 A + echinenone + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428609", "l": "Type I Na+-coupled phosphate co-transport (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1362465", "l": "GHBP binds GHR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50383", "l": "3 H(+) + 3 malonyl-CoA <=> 1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013895", "l": "Caspase-8 processing within TLR3 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709317", "l": "CO binds to free ferrohemoglobin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43816", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48315", "l": "benzoyl-CoA + H(+) + NADPH + O2 <=> 2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45061", "l": "H2O + N-(9Z-octadecenoyl) ethanolamine => (9Z)-octadecenoate + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13185", "l": "H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)"}, {"i": "EC:2.5.1.61", "l": "\"Hydroxymethylbilane synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25526", "l": "9alpha-copalyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23650", "l": "dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH => dTDP-6-deoxy-beta-L-talose + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28728", "l": "Cu(2+)(in) + H(+)(in) => Cu(2+)(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59966", "l": "CoA + O-octanoyl-L-seryl-[protein] => L-seryl-[protein] + octanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10631", "l": "phosphate + tRNA(n+1) <=> a ribonucleoside 5'-diphosphate + tRNA(n)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168849", "l": "tBID binds to inactive BAX protein (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445699", "l": "ATP Hydrolysis By Myosin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610720", "l": "PKA phosphorylates GLI3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47547", "l": "trans-4-hydroxy-L-proline betaine <=> cis-4-hydroxy-D-proline betaine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70494", "l": "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51593", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + toluene => benzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814374", "l": "Kazrin binds periplakin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433488", "l": "Phosphorylation of SHP2 by SFKs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202233", "l": "Inactivation of Lck by Csk (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42351", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16215", "l": "3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP => 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197958", "l": "FPGS-2 transforms THF to THFPG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29284", "l": "L-alanine(in) + Na(+)(in) => L-alanine(out) + Na(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25464", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + longifolene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687088", "l": "PKA phosphorylates MAPKAPK5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641147", "l": "DACT1 binds DVL2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66847", "l": "asperterpenoid A + O2 + reduced [NADPH--hemoprotein reductase] <=> asperterpenoid C + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36531", "l": "(13Z)-docosenoyl-CoA + H(+) + malonyl-CoA = (15Z)-3-oxotetracosenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66421", "l": "ATP + glutathione(in) + H2O + tauroursodeoxycholate(in) => ADP + glutathione(out) + H(+) + phosphate + tauroursodeoxycholate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62882", "l": "(3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + A => 9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0016416", "l": "O-palmitoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10431", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944233", "l": "Association of procollagen type XIX (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858498", "l": "SL (surrogate light chain) binds IgH to form pre-BCR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22397", "l": "1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 => glycolaldehyde + guaiacol + H2O + vanillin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64303", "l": "3-phenylpropylamine + pyruvate <=> 3-phenylpropanal + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10946", "l": "phosphate + pseudouridine => H2O + psi-UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607751", "l": "TRAF6 oligomerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12600", "l": "acetyl-CoA + phosphinothricin <=> CoA + H(+) + N-acetylphosphinothricin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32736", "l": "1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine => 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27639", "l": "phosphate + xanthosine => alpha-D-ribose 1-phosphate + xanthine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3785768", "l": "MRN complex binds DNA double strand breaks (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36649", "l": "CoA + H(+) + N-(2-hydroxyhexadecanoyl)-sphinganine => 2-hydroxyhexadecanoyl-CoA + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373711", "l": "DCC interaction with Netrin-1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.13"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110050", "l": "deaminated glutathione amidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445699", "l": "ATP Hydrolysis By Myosin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14086", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA => 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16151", "l": "5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide => beta-nicotinamide D-ribonucleotide + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30337", "l": "NH4(+) + UTP => CTP + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51543", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-corytuberine + 2 H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654569", "l": "Activated FGFR1 binds FRS2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877941", "l": "RUNX2 binds SMAD1 in the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018705", "l": "1,2-dichloroethene reductive dehalogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17694", "l": "deoxycholoyl-CoA + H2O => CoA + deoxycholate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49562", "l": "(R)-demethyl-4-deoxygadusol + H(+) + H2O + phosphate => D-sedoheptulose 7-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60043", "l": "H2O + N(2)-[(2E)-3-methylhex-2-enoyl]-L-glutaminate <=> (2E)-3-methylhex-2-enoate + L-glutamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62484", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28474", "l": "D-glucarate(in) = D-glucarate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40334", "l": "1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP <=> 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44481", "l": "3,4-dihydroxy-5-all-trans-heptaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-heptaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34678", "l": "CTP + N,N-diacetyllegionaminate <=> CMP-N,N-diacetyllegionaminate + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2562526", "l": "PLK1 phosphorylates OPTN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160915", "l": "Receptor-mediated uptake of HA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696958", "l": "USP44 deubiquitinates CDC20 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437139", "l": "ZnT6 transports zinc into the golgi apparatus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32522", "l": "(2E)-geranyl diphosphate + S-adenosyl-L-methionine <=> (E)-2-methylgeranyl diphosphate + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53486", "l": "17beta-hydroxyandrost-4-ene-3,11-dione + NADP(+) => androst-4-ene-3,11,17-trione + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38978", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59425", "l": "benzylamine + H2O + O2 => benzaldehyde + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50894", "l": "a menaquinol + thiosulfate => a menaquinone + 2 H(+) + hydrogen sulfide + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374896", "l": "Uptake of Noradrenaline (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6785594", "l": "FANCD2 binds FANCI (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26477", "l": "beta-D-galactosyl-(1->4)-L-rhamnose + phosphate <=> alpha-D-galactose 1-phosphate + L-rhamnopyranose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694444", "l": "E and N are recruited to the M lattice (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430190", "l": "p-SLP-76 binds NCK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004095", "l": "carnitine O-palmitoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16226", "l": "1,8-diazacyclotetradecane-2,9-dione + H2O => N-(6-aminohexanoyl)-6-aminohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14389", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}, {"i": "EC:2.4.1.149", "l": "\"N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.n1", "l": "\"Elongation factor 4\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28140", "l": "streptothricin F acid => H2O + streptothricin F"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54152", "l": "a uridine in rRNA + S-adenosyl-L-methionine = a 2'-O-methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65384", "l": "a 5'-(N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O = (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60394", "l": "Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) => Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30007", "l": "ATP + H2O + L-arabinose(out) = ADP + H(+) + L-arabinose(in) + phosphate"}, {"i": "EC:7.5.2.12", "l": "\"ABC-type L-arabinose transporter\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58702", "l": "FADH2 + H(+) + H2O + NADP(+) + rifampicin hemiaminal => FADH2-C4alpha-hydroperoxide + NADPH + rifampicin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36119", "l": "gibberellin A9 + S-adenosyl-L-methionine = O-methyl gibberellin A9 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30606", "l": "15-cis-phytoene + A <=> AH2 + all-trans-phytofluene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36804", "l": "2-hydroxy-2,3-dihydrogenistein => genistein + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165195", "l": "GTP loading by Rheb (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130194", "l": "ABL phosphorylates WAVEs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34860", "l": "3-oxocyclopentanecarbonitrile + 2 H2O => 3-oxocyclopentanecarboxylate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013023", "l": "RHOB GEFs activate RHOB (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58799", "l": "a flavonol 7-O-beta-D-glucoside + malonyl-CoA <=> a flavonol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40788", "l": "H2O + tetracosanoyl-CoA => CoA + H(+) + tetracosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416929", "l": "PTGFR binds PGF2a (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42622", "l": "(Z)-2-methylaminoacrylate + CO2 + NH4(+) => (Z)-2-methylureidoacrylate + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112703", "l": "PTPN11 is phosphorylated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16614", "l": "acetyl-CoA + an arylamine => an N-acetylarylamine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034931", "l": "1-hydroxypyrene methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32454", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate <=> all-trans-phytoene + 2 diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43272", "l": "ganglioside GD3 + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GD2 + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169395", "l": "ISGylation of viral protein NS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29187", "l": "succinate + ubiquinone-8 = fumarate + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799097", "l": "ATM phosphorylates ZNF420 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50196", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13726", "l": "acetyl-CoA + alpha-D-glucosamine 1-phosphate => CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110172", "l": "MBD4 glycosylase mediated recognition and binding of a thymine opposite to a guanine at CpG sequences (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68960", "l": "DNA polymerase epsilon binds at the origin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40825", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198440", "l": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48855", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 <=> 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375135", "l": "Basigin binds Matrix metalloproteinase-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35721", "l": "(S)-versiconol + acetate + H(+) => (3S)-versiconol acetate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22238", "l": "2-deoxy-D-glucose + phosphate => 2-deoxy-D-glucose 6-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016087", "l": "ecdysiostatic hormone activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30669", "l": "germacra-1(10),4,11(13)-trien-12-oate + 3 H(+) + 2 NADPH => germacra-1(10),4,11(13)-trien-12-ol + H2O + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944227", "l": "Association of procollagen type XXII (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592297", "l": "Full activation of MMP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19321", "l": "N,N-dimethylaniline N-oxide = formaldehyde + N-methylaniline"}, {"i": "EC:4.1.2.24", "l": "\"Dimethylaniline-N-oxide aldolase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102245", "l": "lupan-3beta,20-diol synthase activity"}, {"i": "MetaCyc:RXN-12338"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35548", "l": "cyclo(L-tyrosyl-L-tyrosyl) + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53091", "l": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine <=> 2-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265177", "l": "Exocyst complex formation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195304", "l": "Association of beta-catenin with the destruction complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.125"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21026", "l": "H(+) + NADPH + oxalyl-CoA => CoA + glyoxylate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.20"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399985", "l": "AKT1 E17K mutant phosphorylates caspase-9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72722", "l": "eIF2 activation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54946", "l": "(3R)-hydroxy-(5Z)-dodecenoyl-[ACP] + NADP(+) => 3-oxo-(5Z)-dodecenoyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20120", "l": "ATP + L-rhamnulose <=> ADP + H(+) + L-rhamnulose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57446", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine => C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23019", "l": "(2R,3S,4S)-3,4-leucopelargonidin + NADP(+) <=> (2R,3R)-dihydrokaempferol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40785", "l": "CoA + docosanoate + H(+) => docosanoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75244", "l": "FASL binds FAS Receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222128", "l": "NOC2L binds TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0004715", "l": "non-membrane spanning protein tyrosine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696997", "l": "USP24 deubiquitinates DDB2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858387", "l": "Activated STAT3 positively regulates CEBPB transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25019", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450422", "l": "KSRP recruits RNA degradation activities (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004707", "l": "MAP kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10936", "l": "6-decylubiquinone + 2 thiosulfate = 6-decylubiquinol + tetrathionate"}, {"i": "EC:1.8.5.2", "l": "\"Thiosulfate dehydrogenase (quinone)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59137", "l": "ATP + citrate + D-ornithine => AMP + diphosphate + H(+) + N(5)-[(S)-citryl]-D-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35569", "l": "(9Z,12Z)-octadecadienoate + ethanolamine => H2O + N-(9Z,12Z-octadecadienoyl)-ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56569", "l": "globoside Gb4Cer + UDP-N-acetyl-alpha-D-galactosamine => globoside IV3GalNAc-Gb4Cer + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9017507", "l": "RHOJ binds effectors at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61215", "l": "myricetin + UDP-alpha-D-glucose <=> H(+) + myricetin 3-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56374", "l": "3-bromo-4,5-dihydroxybenzoate + 2 H2O + NADP(+) => 3,4-dihydroxybenzoate + bromide + 2 H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801109", "l": "CHM binds RGGT (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004075", "l": "biotin carboxylase activity"}, {"i": "RHEA:13501", "l": "ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate"}, {"i": "EC:6.3.4.14", "l": "\"Biotin carboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18628", "l": "D-galactose + NADP(+) <=> D-galactono-1,5-lactone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209823", "l": "Tyrosine is hydroxylated to dopa (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55731", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8963851", "l": "VD3 dissociates from GC (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12605", "l": "D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2"}, {"i": "EC:2.2.1.7", "l": "\"1-deoxy-D-xylulose-5-phosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201629", "l": "Caspase-mediated cleavage of Tau (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15435", "l": "diphosphate + sophoraflavanone B => (2S)-naringenin + dimethylallyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3239014", "l": "MAPKAPK5 phosphorylates TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624131", "l": "UNC119B binds myristoylated proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015341", "l": "zinc efflux active transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210290", "l": "Interaction of PECAM-1 and SHIP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018808", "l": "RAC3 binds effectors at the plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25180", "l": "4-methyl-2-oxopentanoate + CoA + NAD(+) <=> 3-methylbutanoyl-CoA + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047781", "l": "citrullinase activity"}, {"i": "MetaCyc:CITRULLINASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43774", "l": "H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030798", "l": "trans-aconitate 2-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984708", "l": "Kinesin-2 is a heterotrimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17024", "l": "(2-aminoethyl)phosphonate + pyruvate <=> L-alanine + phosphonoacetaldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30543", "l": "(S)-carnitine + ATP + CoA = (S)-carnitinyl-CoA + ADP + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62178", "l": "alpha-D-glucose 1-phosphate + GMP + 2 H(+) => GDP-alpha-D-glucose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34121", "l": "3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 CoA => 3 H(+) + hexanoyl-CoA + 3 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047231", "l": "pyridoxine 5'-O-beta-D-glucosyltransferase activity"}, {"i": "RHEA:20177", "l": "pyridoxine + UDP-alpha-D-glucose = 5'-O-beta-D-glucosylpyridoxine + H(+) + UDP"}, {"i": "EC:2.4.1.160", "l": "\"Pyridoxine 5'-O-beta-D-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433454", "l": "Phosphorylation of GAB2 by SFKs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29130", "l": "a menaquinol + nitrate <=> a menaquinone + H2O + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937989", "l": "RUNX1 binds PRC1 complexes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20326", "l": "N-hydroxy-4-acetylaminobiphenyl => N-acetoxy-4-aminobiphenyl"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14568", "l": "(11Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxo-(13Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22115", "l": "isoxazolin-5-one + O-acetyl-L-serine <=> 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050120", "l": "N-acetylhexosamine 1-dehydrogenase activity"}, {"i": "KEGG.REACTION:R01202"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33473", "l": "a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-(4R)-4-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940309", "l": "Expression of PERM1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034842", "l": "thiophene-2-carboxylate-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694442", "l": "CNIH2,3 bind GRIA1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.10"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050569", "l": "glycolaldehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102591", "l": "delphinidin 7-O-glucoside acyltransferase (acyl-glucose dependent) activity"}, {"i": "MetaCyc:RXN-15352"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5577259", "l": "MSH2 variant:MSH3-defective DNA mismatch repair (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54490", "l": "1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine => 1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22186", "l": "acenaphthene-1,2-dione + 2 H(+) + 2 NADPH => (+-)-trans-acenaphthene-1,2-diol + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141673", "l": "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27830", "l": "neryl diphosphate = beta-phellandrene + diphosphate"}, {"i": "EC:4.2.3.51", "l": "\"Beta-phellandrene synthase (neryl-diphosphate-cyclizing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17584", "l": "an N-carbamoyl-L-2-amino acid + 2 H(+) + H2O <=> an L-alpha-amino acid + CO2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030883", "l": "endogenous lipid antigen binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56873", "l": "(S)-N-acetyl-1-phenylethylamine + H2O => (S)-1-phenylethylamine + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191654", "l": "c-src associates with Cx43 in gap junctions (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64399", "l": "glycyl-sarcosine(out) + H(+)(out) <=> glycyl-sarcosine(in) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36555", "l": "eicosanoyl-CoA + sphinganine = CoA + H(+) + N-eicosanoylsphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9619355", "l": "CaMKK autophosphorylates in the cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.17", "l": "\"Deoxyribodipyrimidine endonucleosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047670", "l": "anhydrotetracycline monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61327", "l": "(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxycostunolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18784", "l": "H(+) + malonyl-CoA <=> acetyl-CoA + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61214", "l": "H(+) + myricetin 3-O-beta-D-glucoside + UDP => myricetin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22774", "l": "2-dehydro-3-deoxy-L-fuconate + H2O => L-fuconate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41053", "l": "1,2-di-(9Z)-octadecenoyl-3-tetradecanoyl-sn-glycerol + CoA => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.12"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.44"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662599", "l": "MT1M binds cadmium (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15402", "l": "dolichyl phosphate + UDP-alpha-D-glucose => dolichyl beta-D-glucosyl phosphate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63288", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 9-hydroperoxy-(5Z,7E,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57406", "l": "H(+) + NADH + noscapine => NAD(+) + narcotine hemiacetal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180634", "l": "Association of APOBEC3G with single-stranded region of forming HIV-1 minus strand (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39628", "l": "(3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA => (2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18944", "l": "a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+) <=> a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2984226", "l": "PLK1 phosphorylates NEK9 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61365", "l": "3beta-sulfooxy-androst-5-en-17-one(in) + ATP + H2O => 3beta-sulfooxy-androst-5-en-17-one(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111956", "l": "Calmodulin activates Cam-PDE 1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433804", "l": "IKK epsilon is recruited to the Viral dsRNA:TLR3:TICAM1 complex  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-429101", "l": "HMIT co-transports myo-inositol with a proton (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004755", "l": "saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0150047", "l": "G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31739", "l": "a 4'-hydroxyisoflavone + S-adenosyl-L-methionine = a 4'-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.46", "l": "\"Isoflavone 4'-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65019", "l": "chlorothalonil + H2O <=> 4-hydroxychlorothalonil + chloride + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54967", "l": "hexadecanoyl-[ACP] + phosphate <=> hexadecanoyl phosphate + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16455", "l": "2-formylbenzoate + pyruvate => (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25359", "l": "(3Z)-phycoerythrobilin + 2 oxidized 2[4Fe-4S]-[ferredoxin] = biliverdin IXalpha + 4 H(+) + 2 reduced 2[4Fe-4S]-[ferredoxin]"}, {"i": "EC:1.3.7.6", "l": "\"Phycoerythrobilin synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24102", "l": "diisopropyl phosphate + fluoride + 2 H(+) => diisopropyl fluorophosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34937", "l": "diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate => 2 ATP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11341", "l": "5-guanidino-2-oxopentanoate + H(+) => 4-guanidinobutanal + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37280", "l": "ATP + H2O + L-alanyl-L-histidine(out) => ADP + H(+) + L-alanyl-L-histidine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12471", "l": "avenacoside A + H2O <=> 26-desgluco-avenacoside A + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39419", "l": "3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210274", "l": "SIRP beta binds TYROBP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801195", "l": "STEAP3 binds BNIP3L (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19852", "l": "H2O + NADP(+) <=> ADP-D-ribose 2'-phosphate + H(+) + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18724", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate <=> diphosphate + ent-13-epi-manoyl oxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17420", "l": "ATP + N-acetyl-D-glucosamine <=> ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047487", "l": "oligogalacturonide lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31343", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H2O = (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate"}, {"i": "EC:3.1.3.85", "l": "\"Glucosyl-3-phosphoglycerate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009072", "l": "STAT3 phosphorylation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19402", "l": "methanol + NAD(+) => formaldehyde + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18647", "l": "NH4(+) + sym-homospermidine => 2 putrescine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37860", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA => 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018588", "l": "tri-n-butyltin dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784765", "l": "p-Y705-STAT3 dimerizes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34501", "l": "H2O + oxidized 2[4Fe-4S]-[ferredoxin] + pentalenate => 1-deoxypentalenate + 2 H(+) + O2 + reduced 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29841", "l": "2-dehydro-L-idonate + H(+) + NADPH => L-idonate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44390", "l": "1-heptadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA => 1-heptadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23239", "l": "[protein]-L-glutamate 5-O-methyl ester + H2O <=> H(+) + L-glutamyl-[protein] + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693609", "l": "ATM phosphorylates TP53 at S15 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332363", "l": "Autophosphorylation and activation of CAMK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028812", "l": "Expression of interferon-beta (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805035", "l": "TP53 binds STK11 and NUAK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29368", "l": "CMP + H2O => cytidine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20452", "l": "5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2 <=> 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55437", "l": "ferruginol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + salviol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64606", "l": "diphosphate + uridylyl-L-seryl-[protein] => L-seryl-[protein] + UTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76466", "l": "CYP4A11 12-hydroxylates DDCX (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29113", "l": "NADP(+) + ubiquinol-8 => H(+) + NADPH + ubiquinone-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58868", "l": "24-methylidenelophenol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}, {"i": "EC:1.14.18.11", "l": "\"Plant 4-alpha-monomethylsterol monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033040", "l": "sour taste receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381203", "l": "XBP(S) mRNA is translated and XBP1(S) translocates to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035990", "l": "Defective HLCS does not biotinylate 6x(PCCA:PCCB) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53569", "l": "12,13-epoxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-12,13-epoxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37479", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47475", "l": "(2E,4E)-tetradecadienoyl-CoA + H(+) + NADPH <=> (3E)-tetradecenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26215", "l": "aphidicolan-16beta-ol + diphosphate => 9alpha-copalyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11061", "l": "ATP + L-isoleucine + tRNA(Ile) => AMP + diphosphate + L-isoleucyl-tRNA(Ile)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57803", "l": "2,3-dinitrotoluene + NADH + O2 <=> 4-methyl-3-nitrocatechol + H(+) + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21690", "l": "an oxidized polyvinyl alcohol + n H2O2 => a polyvinyl alcohol + n O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708457", "l": "HM13 cleaves HMOX1 dimer (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52175", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41914", "l": "hexadecanoyl-[ACP] + NADP(+) => (2E)-hexadecenoyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11540", "l": "an N-acyl-D-mannosamine + NAD(+) = an N-acyl-D-mannosaminolactone + H(+) + NADH"}, {"i": "EC:1.1.1.233", "l": "\"N-acylmannosamine 1-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61150", "l": "H(+) + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] + UDP => myricetin 3-O-alpha-L-rhamnoside + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37571", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine = 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.21", "l": "\"Cholesterol 7-desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14961", "l": "H2O + S-formylglutathione = formate + glutathione + H(+)"}, {"i": "EC:3.1.2.12", "l": "\"S-formylglutathione hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64641", "l": "H2O + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose => lactose + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662622", "l": "MT1X binds cadmium (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40575", "l": "glutaryl-CoA + H2O = CoA + glutarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654573", "l": "Activated FGFR1 binds SHC1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10986", "l": "(S)-malate + pyruvate => (S)-lactate + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17639", "l": "hop-22(29)-ene => squalene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44310", "l": "1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446209", "l": "Transfer of N-glycan to the protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948180", "l": "Peroxynitrite oxidizes Cys residues (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004999", "l": "vasoactive intestinal polypeptide receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379980", "l": "tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29448", "l": "glycolate(in) => glycolate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32843", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycerol = a 1-acyl-sn-glycero-3-phosphocholine + a triacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57388", "l": "(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] = (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.167", "l": "\"(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine 8-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44783", "l": "2-demethylmenaquinol-9 + S-adenosyl-L-methionine <=> H(+) + menaquinol-9 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32495", "l": "(2E)-geraniol + O2 + reduced [NADPH--hemoprotein reductase] = (6E)-8-hydroxygeraniol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.83", "l": "\"Geraniol 8-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21545", "l": "(2E,6E)-farnesyl diphosphate + ATP => (2E,6E)-farnesyl triphosphate + ADP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045294", "l": "alpha-catenin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875451", "l": "MET phosphorylates CBL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27845", "l": "9H-carbazole + H(+) + NADPH + O2 <=> 2'-aminobiphenyl-2,3-diol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24682", "l": "5,10-methylenetetrahydromethanopterin + NADP(+) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793096", "l": "MRM3 (RNMTL1) methylates guanosine-1370 of 16S rRNA yielding 2'-O-methylguanosine-1370 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034920", "l": "pyrene dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264997", "l": "Oxidation of cysteine to cystine in Proinsulin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41212", "l": "(indol-3-yl)acetate + H(+) + NADH + O2 => 2-hydroxy-(1H-indol-3-yl)acetate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694522", "l": "Inner coat assembly and cargo binding (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5681980", "l": "ATG12 binds ATG7 dimer (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22274", "l": "(20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58157", "l": "ATP + H2O + 4 Na(+)(in) => ADP + H(+) + 4 Na(+)(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33753", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676133", "l": "CD74 binds MIF (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50548", "l": "prostaglandin E1 = H2O + prostaglandin A1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6795290", "l": "TORC2 complex phosphorylates SGK1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45917", "l": "12-hydroxyoctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(13-hydroxy-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21879", "l": "(6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) <=> (S)-usnate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53607", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668398", "l": "CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683801", "l": "CHEK2 phosphorylates BRCA1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39506", "l": "(2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH <=> (13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55412", "l": "[phosphate](n) + GTP = [phosphate](n+1) + GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636397", "l": "PtpA binds ATP6V1H (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63987", "l": "5-hydroxyuridine + ATP <=> 5-hydroxyuridine 5'-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41839", "l": "H(+) + hexanoyl-[ACP] + malonyl-[ACP] <=> 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5221061", "l": "TDG excises 5-carboxylcytosine (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30370", "l": "adenosylcob(III)alamin 5'-phosphate + H2O <=> adenosylcob(III)alamin + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11440", "l": "2,3,5,6-tetrachlorophenol + NADPH + O2 = 2,3,5,6-tetrachlorohydroquinone + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-606287", "l": "RSF complex binds the centromere (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56389", "l": "(5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 => (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018693", "l": "ethylbenzene hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0030235", "l": "nitric-oxide synthase regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417829", "l": "P2RY12 binds ADP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5676229", "l": "WIPIs bind PI3P (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64954", "l": "dCMP + H(+) + phosphate => dCDP + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034431", "l": "bis(5'-adenosyl)-hexaphosphatase activity"}, {"i": "RHEA:32047", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = adenosine 5'-pentaphosphate + AMP + 2 H(+)"}, {"i": "RHEA:32051", "l": "H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate = adenosine 5'-tetraphosphate + AMP + 2 H(+)"}, {"i": "EC:3.6.1.60", "l": "\"Diadenosine hexaphosphate hydrolase (AMP-forming)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25519", "l": "an acyl-CoA + tropine <=> CoA + H(+) + O-acyltropine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070698", "l": "type I activin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453183", "l": "p-Y348-SYK dissociates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211193", "l": "Homodimerization  of DFF40 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35393", "l": "(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419389", "l": "LPA-binding receptors bind LPA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43066", "l": "holo-[2-methylbutanoate polyketide synthase] + lovastatin carboxylate => (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + monacolin J carboxylate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004565", "l": "beta-galactosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983194", "l": "Kinesin-1 is a heterotetramer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65545", "l": "ganglioside GM1 + H2O => an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-D-Glc"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050369", "l": "[tyrosine 3-monooxygenase] kinase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052610", "l": "beta-cryptoxanthin hydroxylase activity"}, {"i": "RHEA:30327", "l": "beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = all-trans-zeaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "MetaCyc:RXN-8026"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0032183", "l": "SUMO binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804724", "l": "MDM2 ubiquitinates phosphorylated MDM4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11226", "l": "ADP + D-alanyl-D-alanine + H(+) + phosphate => ATP + 2 D-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20611", "l": "glycolaldehyde + pyruvate => 2-dehydro-3-deoxy-D-arabinonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937989", "l": "RUNX1 binds PRC1 complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35959", "l": "H(+) + NADPH + O2 + tryprostatin B = demethoxyfumitremorgin C + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.23"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.81", "l": "\"Streptogrisin B\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001077", "l": "(1->3),(1->4)-beta-glucan binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454843", "l": "E-cadherin degradation by MMP3, MMP7 and plasmin. (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665998", "l": "MKL1 binds SRF (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2129362", "l": "Fibrillin microfibril assembly (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20211", "l": "ADP + H(+) + xylitol 5-phosphate => ATP + xylitol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851979", "l": "BTNL9 binds immune cell surfaces (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448480", "l": "IL22 binds IL22RA1:JAK1 receptor complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427383", "l": "CBX3 (HP1gamma) binds histone H3 dimethylated at lysine-9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-873917", "l": "Translocation of STAT1 dimer to nucleus (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534240", "l": "HSPG2 (perlecan) degradation by MMP14, MMP15 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42244", "l": "H(+) + malonyl-[ACP] + propanoyl-CoA = 3-oxopentanoyl-[ACP] + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23580", "l": "prostaglandin H2 = prostaglandin I2"}, {"i": "EC:5.3.99.4", "l": "\"Prostaglandin-I synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14136", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> 16-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43439", "l": "coproporphyrinogen III + 3 O2 <=> coproporphyrin III + 3 H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866277", "l": "AP-2 directly binds some endocytic cargo (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052887", "l": "7,9,9'-tricis-neurosporene:quinone oxidoreductase activity"}, {"i": "KEGG.REACTION:R09658"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870465", "l": "RGGT binds the RAB-binding subunit (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14308", "l": "ATP + L-proline + tRNA(Pro) <=> AMP + diphosphate + L-prolyl-tRNA(Pro)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450533", "l": "PKCdelta phosphorylates HuR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35220", "l": "8-oxo-dADP + H2O => 8-oxo-dAMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20186", "l": "a CMP-N-acyl-beta-neuraminate + H2O => an N-acylneuraminate + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16213", "l": "3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP"}, {"i": "EC:2.4.1.224", "l": "\"Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032794", "l": "GTPase activating protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6813749", "l": "ALDH1A1 oxidises GA to DGA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35689", "l": "3-oxotetradecasphinganine + H(+) + NADPH => NADP(+) + tetradecasphinganine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045133", "l": "2,3-dihydroxybenzoate 3,4-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19504", "l": "4-guanidinobutanoate + H2O <=> 4-aminobutanoate + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48014", "l": "2-hydroxy-5-methylquinone + H(+) + H2O + NADP(+) + nitrite => 4-methyl-5-nitrocatechol + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19598", "l": "H2O + L-arginine => L-citrulline + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62845", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-fucose => beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-D-glucosamine + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64398", "l": "glycyl-sarcosine(in) + H(+)(in) => glycyl-sarcosine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40414", "l": "1,2-dihexadecanoyl-sn-glycero-3-CDP + myo-inositol <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34509", "l": "N,N-diacetyllegionaminate + phosphate => 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35434", "l": "1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside <=> 4-hydroxy-3-methoxybenzoate + cyanidin 3,7-di-O-beta-D-glucoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071551", "l": "RIP homotypic interaction motif binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61051", "l": "lochnericine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + horhammericine + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201515", "l": "Active ALK recruits PI3K (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3858475", "l": "ppDVL recruits RAC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58422", "l": "3-methyl-2-butenal + H(+) + NADPH => NADP(+) + prenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785594", "l": "FANCD2 binds FANCI (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202709", "l": "JAM2 dimerises (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047667", "l": "AMP-thymidine kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44246", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-(9Z-octadecenoyl)-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788611", "l": "HYKK phosphorylates 5HLYS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31475", "l": "soyasapogenol B + UDP-alpha-D-glucuronate = H(+) + soyasapogenol B 3-O-beta-D-glucuronate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848713", "l": "PTK6 binds BCAR1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.18"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222020", "l": "NUAK1 phosphorylates TP53 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48836", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59914", "l": "(E)-4-hydroxynon-2-enoate + 2 H(+) + NADPH => (E)-4-hydroxynon-2-enal + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617410", "l": "GLI3R binds the GLI2 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002196", "l": "Ser-tRNA(Ala) hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41598", "l": "(5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+) => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781814", "l": "USP19 deubiquitinates RNF123 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34193", "l": "(2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+) => (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43564", "l": "4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + L-alanine = [5-(aminomethyl)-3-furyl]methyl phosphate + pyruvate"}, {"i": "EC:2.6.1.108", "l": "\"(5-formylfuran-3-yl)methyl phosphate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17106", "l": "malonyl-[ACP] + S-adenosyl-L-methionine => malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57616", "l": "dihydro-ML-236C-[compactin nonaketide synthase] + H2O = dihydro-ML-236C carboxylate + H(+) + holo-[compactin nonaketide synthase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000411", "l": "RANBP2 SUMOylates PML with SUMO2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39609", "l": "(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+) => (2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209098", "l": "p-T38-ETS1/p-T72-ETS2 stimulates transcription of p16INK4A mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11639", "l": "NADP(+) + prostaglandin E1 <=> 15-oxoprostaglandin E1 + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672172", "l": "PI3-kinase binds to mutant PDGFR receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163689", "l": "Dephosphorylation of pChREBP (Ser 196) by PP2A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-389862", "l": "Conversion of glyoxylate to oxalate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35820", "l": "5,6,7,8-tetrahydromethanopterin + NADP(+) => 7,8-dihydromethanopterin + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63544", "l": "H2O + kinetensin = kinetensin-(1-8) + L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59076", "l": "bis(myo-inositol) 1,3'-phosphate + 2 GDP-alpha-D-mannose = 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + 2 GDP + 2 H(+)"}, {"i": "EC:2.4.1.361", "l": "\"GDP-mannose:di-myo-inositol-1,3'-phosphate beta-1,2-mannosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2529020", "l": "CK2 phosphorylates condensin I subunits (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797961", "l": "CHDH oxidises Cho to BETALD (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39673", "l": "(9Z,12Z)-hexadecadienoyl-CoA + A + 2 H2O => (9Z)-hexadecenoyl-CoA + AH2 + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66185", "l": "3',5'-cyclic AMP(in) + ATP + H2O => 3',5'-cyclic AMP(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50573", "l": "acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19620", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008696", "l": "4-amino-4-deoxychorismate lyase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062180", "l": "25-hydroxycholecalciferol-23-hydroxylase activity"}, {"i": "RHEA:46616", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61550", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14480", "l": "a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445448", "l": "HHIP binds Hedgehog (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033715", "l": "nucleoside oxidase activity"}, {"i": "RHEA:28651", "l": "inosine + O2 = 9-riburonosylhypoxanthine + H(+) + H2O"}, {"i": "EC:1.1.3.28", "l": "\"Nucleoside oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49796", "l": "an N-(fatty acyl)-glycine + H2O = a fatty acid + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322140", "l": "Defective MTR does not transfer CH3 group from MeCbl to HCYS (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0000339", "l": "RNA cap binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033972", "l": "proclavaminate amidinohydrolase activity"}, {"i": "MetaCyc:3.5.3.22-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168885", "l": "Haptoglobin binds Hemoglobin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60618", "l": "ethanolamine + N-dodecanoyl-heptadecasphing-4-enine-1,3-cyclic phosphate => N-dodecanoyl-heptadecasphing-4-enine-1-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58988", "l": "(E)-4-hydroxynon-2-enal + H2O + O2 = (E)-4-hydroxynon-2-enoate + H(+) + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62017", "l": "L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose => 3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30180", "l": "oxalate + oxidized 2[4Fe-4S]-[ferredoxin] => 2 CO2 + reduced 2[4Fe-4S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0022839", "l": "ion gated channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876789", "l": "CARNMT1 methylates CARN to Anserine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12520", "l": "L-dopa = (E)-caffeate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928576", "l": "RHOA:GTP binds ROCK, activating it (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49956", "l": "5,10-dihydrophenazine 1-carboxylate + O2 = H2O2 + phenazine-1-carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389857", "l": "Peptide transfer from P-site to A-site (peptide bond formation) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24001", "l": "a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] => a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951727", "l": "cAMP binds PKA tetramer (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21106", "l": "25-hydroxycholesterol + A + H2O => AH2 + cholesterol + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31654", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42088", "l": "all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418868", "l": "Recruitment of Src and Fyn to DCC:FADK1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11817", "l": "aldehydo-D-glucose 6-phosphate => keto-D-fructose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731924", "l": "EDNRA binds EDNs (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13906", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine => a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448744", "l": "IL20RA binds IL20RB (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73757", "l": "Binding of RRN3 to RNA Polymerase I (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30305", "l": "germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => (+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11484", "l": "2 [Fe(III)cytochrome c](out) + a quinol = 2 [Fe(II)cytochrome c](out) + a quinone + 2 H(+)(out)"}, {"i": "EC:7.1.1.8", "l": "\"Quinol--cytochrome-c reductase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002135", "l": "CTP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1801587", "l": "Expression of CPT1A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19944", "l": "norcoclaurine + S-adenosyl-L-methionine <=> coclaurine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56629", "l": "5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H2O => chloride + 2 H(+) + maleylacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27372", "l": "acetoin + CoA + NAD(+) <=> acetaldehyde + acetyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59057", "l": "2 methanethiol + NAD(+) => dimethyl disulfide + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51274", "l": "CoA + H(+) + N-(9Z-octadecenoyl)glycine => (9Z)-octadecenoyl-CoA + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56105", "l": "2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2 => 4,4'-diaponeurosporenal + 2 A + 3 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434362", "l": "Recruitment Of Cytoplasmic Proteins To Vesicles (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029460", "l": "PAK1 phosphorylates LIMK1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913370", "l": "Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027670", "l": "ESTG binding induces ESR depalmitoylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.84", "l": "\"Ste24 endopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942302", "l": "MMP13 cleaves OPTC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202966", "l": "Caspase mediated cleavage of HIP-55 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432067", "l": "Aquaporin-4 passively transports water out of cell (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37087", "l": "[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47210", "l": "2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211959", "l": "CYP3A43 6b-hydroxylates TEST (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633241", "l": "Defective ALG14 does not transfer GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55598", "l": "globoside NORint + H(+) + UDP => globoside NOR1 + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47418", "l": "a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose + H(+) => an NDP-alpha-D-glucose + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624132", "l": "UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11227", "l": "ATP + 2 D-alanine <=> ADP + D-alanyl-D-alanine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21869", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O => 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62776", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35899", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17321", "l": "L-tryptophan + S-adenosyl-L-methionine = 2-methyl-L-tryptophan + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.106", "l": "\"Tryptophan 2-C-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654510", "l": "FGFRL1 binds SPRED1/2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46820", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047642", "l": "aldose beta-D-fructosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635446", "l": "Rv3654c binds SFPQ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9645598", "l": "RRAGC,D hydrolyzes GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10443", "l": "D-glucono-1,5-lactone + H2O <=> D-gluconate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2509838", "l": "ITPA hydrolyses dITP to dIMP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026358", "l": "NTF4 binds NTRK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005536", "l": "glucose binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33372", "l": "alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein] => alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1606312", "l": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39382", "l": "(2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H(+) + NADPH <=> (15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66584", "l": "3-oxocholestane + A + H2O = 25-hydroxy 3-oxocholestane + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53632", "l": "(2E,6E)-farnesyl diphosphate = (3S)-(+)-asterisca-2(9),6-diene + diphosphate"}, {"i": "EC:4.2.3.161", "l": "\"(3S)-(+)-asterisca-2(9),6-diene synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32209", "l": "(3Z)-2-oxohex-3-enedioate => (2E,4Z)-2-hydroxyhexa-2,4-dienedioate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166542", "l": "beta-NGF dimer binds to TrkA receptor (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74716", "l": "Insulin binds the insulin receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.39", "l": "\"[Butirosin acyl-carrier protein]--L-glutamate ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60195", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64566", "l": "ilicicolin H => 8-epi-ilicicolin H"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29379", "l": "dGMP + H2O = 2'-deoxyguanosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.31"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60249", "l": "A + H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] => AH2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31039", "l": "dodecanoyl-CoA + FAD + H(+) = (2E)-dodecenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1500804", "l": "Peroxynitrite is reduced by AhpE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043867", "l": "7-cyano-7-deazaguanine tRNA-ribosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1878002", "l": "XYLTs transfer Xyl to core protein (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40207", "l": "(2E)-tetradecenedioyl-CoA + H2O = (3S)-hydroxytetradecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13523", "l": "2 [Fe(II)cytochrome c] + 2 H(+) + pyruvate => (R)-lactate + 2 [Fe(III)cytochrome c]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34994", "l": "L-arginine(out) + L-ornithine(in) <=> L-arginine(in) + L-ornithine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28262", "l": "3-alpha-D-mannopyranosyl-alpha-D-mannopyranose + UDP-alpha-D-xylose = 3-O-(6-O-alpha-D-xylosylphospho-alpha-D-mannopyranosyl)-alpha-D-mannopyranose + H(+) + UMP"}, {"i": "EC:2.7.8.32", "l": "\"3-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose xylosylphosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64427", "l": "H(+)(out) + L-leucyl-L-proline(out) <=> H(+)(in) + L-leucyl-L-proline(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791056", "l": "Expression of CCL2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19562", "l": "androst-4-ene-3,17-dione + H(+) + NADPH + O2 => H2O + NADP(+) + testololactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27623", "l": "geranylgeranyl diphosphate + 7 isopentenyl diphosphate => 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114558", "l": "Thrombin-activated PARs activate Gq (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050452", "l": "CoA-glutathione reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46478", "l": "4alpha-formyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48763", "l": "L-threitol + NAD(+) <=> H(+) + L-erythrulose + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051993", "l": "abscisic acid glucose ester beta-glucosidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445714", "l": "Aquaporin-3 passively transports water out of cell (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042959", "l": "alkanesulfonate transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848370", "l": "IL18 binds IL18R1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59419", "l": "H2O + O2 + tryptamine <=> H2O2 + indole-3-acetaldehyde + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16155", "l": "an aldehyde + H2O2 + NH4(+) => an aliphatic amine + H2O + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51902", "l": "acetate + spermidine => H2O + N(1)-acetylspermidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.25", "l": "\"Methane monooxygenase (soluble)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694265", "l": "nsp13 helicase melts secondary structures in SARS-CoV-2 genomic RNA template (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203862", "l": "Dicer cleaves pre-miRNA to yield duplex miRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14428", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52816", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140619", "l": "DNA strand exchange activator activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034882", "l": "cis-aconitamide amidase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45308", "l": "H(+) + NADPH + prostaglandin D2-ethanolamide = 11beta-prostaglandin F2-ethanolamide + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17673", "l": "quercetin + S-adenosyl-L-methionine = 3',4',5,7-tetrahydroxy-3-methoxyflavone + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.76", "l": "\"Quercetin 3-O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56748", "l": "an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42939", "l": "S-adenosyl-L-methionine + uridine(32) in tRNA <=> 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53051", "l": "2-hydroxyestrone + UDP-alpha-D-glucuronate <=> 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61732", "l": "steviol + UDP-alpha-D-glucose = H(+) + steviolmonoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951499", "l": "Loading of antigenic peptides on to class I MHC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46554", "l": "2 [Fe(III)-cytochrome b5] + a (9Z)-octadec-9-en-12-ynoyl-containing glycerolipid + 2 H2O => 2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388831", "l": "Phosphorylation of CD28 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20202", "l": "ATP + H2O + L-phenylalanine => AMP + D-phenylalanine + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22591", "l": "4-aminobutanal <=> 1-pyrroline + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40899", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5627775", "l": "Autophosphorylation of PAK1,2,3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14785", "l": "RNA(n) + UTP = diphosphate + RNA(n)-3'-uridine ribonucleotide"}, {"i": "EC:2.7.7.52", "l": "\"RNA uridylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011543", "l": "DCA binds PDK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32886", "l": "(11R)-dihydroartemisinic aldehyde + NADP(+) <=> (+)-artemisinic aldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168848", "l": "tBID binds to inactive BAK protein (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433456", "l": "Recruitment of STATs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32153", "l": "(12E)-9alpha-labda-8(17),12,14-triene + diphosphate => 9alpha-copalyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641147", "l": "DACT1 binds DVL2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334179", "l": "DNMT3A:DNMT3L binds chromatin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62443", "l": "[(1->4)-alpha-D-galacturonosyl methyl ester](n) <=> 4-deoxy-6-O-methyl-L-threo-hex-4-enopyranuronate + [(1->4)-alpha-D-galacturonosyl methyl ester](n-1)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928656", "l": "gamma-secretase cleaves EPHB2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12483", "l": "5-aminolevulinate + pyruvate <=> 4,5-dioxopentanoate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14031", "l": "AH2 + selenate => A + H2O + selenite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16052", "l": "adenosylcob(III)inamide-GDP + alpha-ribazole <=> adenosylcob(III)alamin + GMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32992", "l": "2 a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2404144", "l": "Parenchymal atROL translocates to HSCs (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66071", "l": "4-methyl-2-oxopentanoate + L-kynurenine <=> H2O + kynurenate + L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864595", "l": "TFAP2B homodimer binds YEATS4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38746", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-octadecenoyl)-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534240", "l": "HSPG2 (perlecan) degradation by MMP14, MMP15 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25954", "l": "2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate => 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21793", "l": "NADP(+) + propan-2-ol => acetone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043823", "l": "spheroidene monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43906", "l": "all-trans-retinyl hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21940", "l": "AH2 + O2 + squalene = (S)-2,3-epoxysqualene + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6797100", "l": "CCNK binds CDK13 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28534", "l": "dTTP + H2O = diphosphate + dTMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.62", "l": "\"5-deoxyribulose 1-phosphate aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25010", "l": "N-hydroxy-L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013159", "l": "CDC42 GEFs activate CDC42 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58213", "l": "ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] => dihydroserpentine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18785", "l": "A + gibberellin A12 aldehyde + H2O = AH2 + gibberellin A12 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48294", "l": "ganglioside Fuc-GM1 + GDP + H(+) => ganglioside GM1 + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106231", "l": "protein-propionyllysine depropionylase activity"}, {"i": "RHEA:23500", "l": "H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+) = 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209815", "l": "Tyrosine is monoiodinated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54770", "l": "[LarE protein]-dehydroalanine + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide => [LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47520", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADPH = isolithocholate + NADP(+)"}, {"i": "EC:1.1.1.393", "l": "\"3-beta-hydroxycholanate 3-dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56574", "l": "globoside Gb3Cer + H(+) + UDP => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191971", "l": "THCA is translocated from the mitochondrial matrix to the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1467466", "l": "ABCA4 mediates atRAL transport (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21739", "l": "(3S)-3,6-diaminohexanoate <=> (3S,5S)-3,5-diaminohexanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003937", "l": "IMP cyclohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004329", "l": "formate-tetrahydrofolate ligase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0004027", "l": "alcohol sulfotransferase activity"}, {"i": "MetaCyc:ALCOHOL-SULFOTRANSFERASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.296", "l": "\"Omega-hydroxyceramide transacylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-706479", "l": "TAK1 is activated (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-996727", "l": "REST recruits the BHC complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296462", "l": "Defective CUBN does not transport GIF:Cbl (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004634", "l": "phosphopyruvate hydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426157", "l": "SREBP1A,2 binds the MVK promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421495", "l": "Synthesis of ALAS2 nascent polypeptide (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9006844", "l": "IL21:IL21R:JAK1 binds IL2RG:JAK3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8858428", "l": "FCAMR binds IgA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086086", "l": "voltage-gated potassium channel activity involved in AV node cell action potential repolarization"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28040", "l": "[thioredoxin]-dithiol + CDP => [thioredoxin]-disulfide + dCDP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689544", "l": "UCHL5 binds INO80 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641205", "l": "RSPO:LGR binds ZNRF3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18684", "l": "phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine <=> phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097621", "l": "monoamine oxidase activity"}, {"i": "RHEA:26414", "l": "a secondary aliphatic amine + H2O + O2 = a primary amine + an aldehyde + H2O2"}, {"i": "EC:1.4.3.4", "l": "\"Monoamine oxidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685681", "l": "Synthesis of SARS-CoV-1 plus strand subgenomic mRNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806610", "l": "Keratin filament formation (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159868", "l": "Furin cleaves pro-factor VII to factor VII (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941895", "l": "Formation of CDK4/6:CCND complexes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12669", "l": "H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate"}, {"i": "EC:3.1.3.43", "l": "\"[Pyruvate dehydrogenase (acetyl-transferring)]-phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42816", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39737", "l": "3,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59838", "l": "3-deoxyglucosone + L-lysyl-[protein] + phosphate => H2O + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41441", "l": "(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 => (1R)-(2-amino-1-hydroxyethyl)phosphonate + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211191", "l": "Association of DFF with alpha:beta importin (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55031", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + S-adenosyl-L-methionine <=> an N-methylornithine lipid + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047535", "l": "2-alkyn-1-ol dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12105", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP => 7,8-dihydrofolate + dTMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1237119", "l": "Acireductone is oxidized to MOB (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010284", "l": "lariciresinol reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928591", "l": "EPH:EFN tetramers oligomerise (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102553", "l": "lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12990", "l": "dolichyl beta-D-mannosyl phosphate + H2O => D-mannose + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215144", "l": "TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3640862", "l": "Tankyrase binds AXIN (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606583", "l": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8867344", "l": "OMA1 hydrolyses OPA1 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382057", "l": "Release of novel PDGFs as latent factors (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65155", "l": "(2S)-naringenin + UDP-alpha-D-glucose <=> (2S)-naringenin 7-O-beta-D-glucoside + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5221061", "l": "TDG excises 5-carboxylcytosine (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186819", "l": "SH2 domain of Src binds to the active receptor (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964619", "l": "PAK1 binds ARHGEF6 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951727", "l": "cAMP binds PKA tetramer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006325", "l": "EPO binds EPOR:JAK2:LYN:IRS2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "65.103521800041733", "identifiers": [{"i": "GO:0016769", "l": "transferase activity, transferring nitrogenous groups"}, {"i": "EC:2.6.-.-", "l": "\"Transferring nitrogenous groups\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198314", "l": "DAG stimulates protein kinase C-delta (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41234", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.20"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18619", "l": "ADP + CO2 + phosphoenolpyruvate => ATP + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62962", "l": "cholesta-5,7-dien-3beta-ol(out) => cholesta-5,7-dien-3beta-ol(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848726", "l": "PTK6 phosphorylates BCAR1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013143", "l": "RAC1 GEFs activate RAC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30251", "l": "2 a ubiquinol + n H(+)(in) + O2 = 2 a ubiquinone + n H(+)(out) + 2 H2O"}, {"i": "EC:7.1.1.3", "l": "\"Ubiquinol oxidase (H(+)-transporting)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.367", "l": "\"UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199093", "l": "CXADR binds to AMICA1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38005", "l": "6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + homogentisate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102783", "l": "beta-carotene oxygenase activity"}, {"i": "MetaCyc:RXN-7883"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444433", "l": "Cho transports from the extracellular space to the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21743", "l": "2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol <=> [thioredoxin]-disulfide + H(+) + hydrogen sulfide + pyruvate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102438", "l": "laricitrin 4'-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-13914"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63158", "l": "docosanoate + taurine => H2O + N-docosanoyl-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662608", "l": "MT2A binds cadmium (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46969", "l": "A + dihydroisopentenyldehydrorhodopin => AH2 + isopentenyldehydrorhodopin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17695", "l": "CoA + deoxycholate + H(+) => deoxycholoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.3.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847977", "l": "FRK phosphorylates PTEN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451846", "l": "LFT binds to FT and DS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38238", "l": "(9Z)-octadecenoyl-CoA + octadecan-1-ol <=> 1-O-octadecyl (9Z)-octadecenoate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77068", "l": "Activation of GT (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008855", "l": "exodeoxyribonuclease VII activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61931", "l": "(R)-miconazole(in) + ATP + H2O <=> (R)-miconazole(out) + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10982", "l": "D-serine => L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55580", "l": "ATP + H2O + L-glutamine = AMP + 2 H(+) + N(5)-phospho-L-glutamine + phosphate"}, {"i": "EC:2.7.3.13", "l": "\"Glutamine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661625", "l": "FVIII is secreted (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22197", "l": "(9Z,12Z)-octadecadienoyl-CoA + AH2 + O2 => (6Z,9Z,12Z)-octadecatrienoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61212", "l": "myricetin + UDP-alpha-D-glucose = H(+) + myricetin 3-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16179", "l": "2 H(+) + NADH + retinoate => H2O + NAD(+) + retinal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5660663", "l": "Caspase-8 cleaves IL1B precursor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62798", "l": "aurasperone A + 2 H2O + NADP(+) => H(+) + NADPH + O2 + 2 rubrofusarin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15087", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + N-acetyl-D-galactosamine => an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163625", "l": "Glucagon binds to Glucagon receptor (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50836", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 = 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2424476", "l": "Activation of RAC1 by VAV2/3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52860", "l": "a short-chain fatty acid + ATP + CoA = a short chain fatty acyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050300", "l": "aminoglycoside 6-kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189406", "l": "4 PBGs bind to form HMB (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51072", "l": "a phenol + a phenyl sulfate = a phenol + a phenyl sulfate"}, {"i": "EC:2.8.2.22", "l": "\"Aryl-sulfate sulfotransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "66.254021125069187", "identifiers": [{"i": "GO:0046943", "l": "carboxylic acid transmembrane transporter activity"}, {"i": "REACT:R-HSA-390347", "l": "Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103026", "l": "fructose-1-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615910", "l": "SUMOylation of PCNA with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63065", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA => 3 CO2 + 4 CoA + tetraacetate lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29948", "l": "H(+)(in) + L-rhamnopyranose(in) => H(+)(out) + L-rhamnopyranose(out)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0046921", "l": "alpha-(1->6)-fucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12018", "l": "(-)-germacrene D + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632412", "l": "PTK2 is recruited to methylated ESR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20116", "l": "beta-D-glucose 1-phosphate <=> beta-D-glucose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24966", "l": "calcitetrol + H2O + 2 oxidized [adrenodoxin] => calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49962", "l": "5,10-dihydrophenazine + CO2 + H2O2 => (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141046", "l": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42633", "l": "adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + 8-methyladenosine(2503) in 23S rRNA + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008489", "l": "UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity"}, {"i": "MetaCyc:RXN-10764"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928607", "l": "p-EPHs bind VAV2,3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696267", "l": "RND3 binds GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60443", "l": "H2O + methyl acetate <=> acetate + H(+) + methanol"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034811", "l": "benzo(a)pyrene 9,10-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50318", "l": "ethanol + H(+) + octadecanoate => ethyl octadecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.43", "l": "\"Beta-L-rhamnosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56422", "l": "adenosine 3',5'-bisphosphate + H(+) + holo-[D-alanyl-carrier protein] => apo-[D-alanyl-carrier protein] + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211224", "l": "Association of DFF40 with DFF45 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18194", "l": "H2O + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] => (S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58073", "l": "a 4,5-didehydrojasmonate + H(+) + NADPH => a jasmonate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805811", "l": "Release of SEPT4 from mitochondria (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67085", "l": "ATP + H2O + hexacosanoate(in) => ADP + H(+) + hexacosanoate(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218642", "l": "PTK2 autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0016653", "l": "oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"}, {"i": "EC:1.6.2.-", "l": "\"With a heme protein as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5628871", "l": "BRD7 promotes EP300-mediated acetylation of TP53 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49685", "l": "H(+) + NADH + O2 + resorcinol => benzene-1,2,4-triol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011941", "l": "Estrogen-responsive BCL2 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "79.238648346243679", "identifiers": [{"i": "GO:0016695", "l": "oxidoreductase activity, acting on hydrogen as donor"}, {"i": "EC:1.12.-.-", "l": "\"Acting on hydrogen as donors\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60057", "l": "a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H(+) + NADH + O2 => a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + 2 H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038121", "l": "C-C motif chemokine 21 receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617815", "l": "BBSome binds RAB3IP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869580", "l": "DEK binds TFAP2A homodimers (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205056", "l": "PRDM4 inhibits cyclin E transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5138459", "l": "WNT5A:FZD4 is endocytosed (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65495", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + CO2 + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52098", "l": "9-hydroxy-octadecanoate + H(+) + octadecanoate => 9-octadecanoyloxy-octadecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211924", "l": "CYP4B1 12-hydroxylates ARA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700171", "l": "Active ALK phosphorylates PLCG1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40727", "l": "1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid = a 1-acylglycerone 3-phosphate + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39255", "l": "(13Z)-3-oxodocosenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(13Z)-docosenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61269", "l": "H2O + L-2-aminohexanoate + O2 => 2-oxohexanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12067", "l": "5-oxopentanoate + H2O + NAD(+) <=> glutarate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0001640", "l": "adenylate cyclase inhibiting G protein-coupled glutamate receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23456", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 = A + crepenynate + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65994", "l": "5,6-trans-vitamin D3 => calciol + hnu"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043836", "l": "xanthine hydrolase activity"}, {"i": "MetaCyc:R127-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149433", "l": "Synthesis of VPU protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24785", "l": "3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)"}, {"i": "RHEA:27846", "l": "(2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2 = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+)"}, {"i": "EC:1.14.13.127", "l": "\"3-(3-hydroxy-phenyl)propanoic acid hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202489", "l": "Oligomerization of Bcl10 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008688", "l": "3-(3-hydroxyphenyl)propionate hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66624", "l": "cholest-4-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (25S)-3-oxocholest-4-en-26-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20982", "l": "2 biliverdin IXalpha + 2 H2O => 2 bilirubin IXalpha + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215426", "l": "COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48006", "l": "3,4-dimethoxybenzaldehyde + glycolaldehyde + guaiacol + H2O => 1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25707", "l": "H(+) + N,N-dihydroxy-L-dihomomethionine => (E)-5-(methylsulfanyl)pentanal oxime + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659899", "l": "Defective SI does not hydrolyze maltotriose (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034835", "l": "2-mercaptobenzothiazole monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32533", "l": "alpha-D-mannose 1-phosphate + D-glucose => 4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20122", "l": "ATP + L-glutamine + tRNA(Gln) => AMP + diphosphate + L-glutaminyl-tRNA(Gln)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52758", "l": "an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-cysteinylglycine + L-glutamate => an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437936", "l": "p-Y348-SYK phosphorylates VAV family (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247922", "l": "GGCT transforms gGluCys to OPRO (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.99.2", "l": "\"Aminopyrimidine aminohydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61995", "l": "N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23541", "l": "ATP + L-glutamate + tRNA(Glu) => AMP + diphosphate + L-glutamyl-tRNA(Glu)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55515", "l": "cucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-hydroxycucurbitadienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168894", "l": "p-STAT5A/B dissociates from the Growth Hormone receptor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39606", "l": "(3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA <=> (2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18682", "l": "phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine => phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24298", "l": "H(+) + N-carbamoyl-L-aspartate => (S)-dihydroorotate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21955", "l": "5alpha-pregnane-3,20-dione + NADP(+) <=> H(+) + NADPH + progesterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46375", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032574", "l": "5'-3' RNA helicase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76456", "l": "O-atom dealkylation of dextromethorphan (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.52"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110319", "l": "Elongation by POLH (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66046", "l": "(2S)-2-aminobutanoate + H2O + kynurenate => 2-oxobutanoate + L-kynurenine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45781", "l": "(9Z)-octadecenoyl-CoA + di-(9Z)-octadecenoylglycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42821", "l": "2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2 => H2O + 2 NADP(+) + tetracenomycin C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21477", "l": "[(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->3)-beta-D-glucosyl](n+1) + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11988", "l": "1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine = 1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.79", "l": "\"Cyclopropane-fatty-acyl-phospholipid synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.294", "l": "\"Chlorophyll(ide) b reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22858", "l": "(7S)-O-acetylsalutaridinol + CoA => (7S)-salutaridinol + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62312", "l": "salicylate + UDP-alpha-D-glucose = H(+) + salicylate 2-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57552", "l": "[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41291", "l": "H2O + N-dodecanoylsphing-4-enine = dodecanoate + sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25589", "l": "D-threo-isocitrate + NADP(+) => (S)-oxalosuccinate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15945", "l": "aldehydo-D-glucose 6-phosphate + L-lysyl-[protein] = H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19496", "l": "D-cellobiose + phosphate <=> alpha-D-glucose 1-phosphate + D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23242", "l": "(6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate => 5-formyltetrahydrofolate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43032", "l": "3-chloro-D-alanine = 2-aminoprop-2-enoate + chloride + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66243", "l": "ATP + CoA + IC-asc-C9 <=> AMP + diphosphate + IC-asc-C9-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029690", "l": "Caspase-6 translocates to the nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55155", "l": "H(+) + L-prolyl-[peptidyl-carrier protein] + 2 oxidized [electron-transfer flavoprotein] <=> (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42584", "l": "1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132271", "l": "Factor H displaces Bb in Cb:Bb complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2473584", "l": "Collagen type III degradation by MMP15 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32731", "l": "a diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H(+)"}, {"i": "EC:3.1.1.79", "l": "\"Hormone-sensitive lipase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26325", "l": "(8Z,11Z)-5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine = (8Z,11Z)-5-(pentadeca- 8,11,14-trien-1-yl)resorcinol-3-methyl ether + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.n7", "l": "\"5-pentadecatrienyl resorcinol O-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031856", "l": "Sulfido conjugates translocate from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50893", "l": "a menaquinone + 2 H(+) + hydrogen sulfide + sulfite => a menaquinol + thiosulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15623", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP => an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671737", "l": "p-T774-PKN1 binds CDC25C (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6786650", "l": "DDHD1,2 hydrolyse PA (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59834", "l": "ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein] => ATP + N(6)-(D-fructosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938887", "l": "PML binds RUNX1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41701", "l": "1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + glutarate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13551", "l": "diphosphate + GDP-beta-L-fucose => beta-L-fucose 1-phosphate + GTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40446", "l": "6-deoxy-6-sulfo-D-fructose + ATP <=> 6-deoxy-6-sulfo-D-fructose 1-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070573", "l": "metallodipeptidase activity"}, {"i": "REACT:R-HSA-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23437", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O => 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55058", "l": "a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => a 12-hydroxyjasmonyl-L-alpha-amino acid + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42828", "l": "2-hydroxy-5-methyl-1-naphthoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2,7-dihydroxy-5-methyl-1-naphthoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}, {"i": "EC:1.14.15.31", "l": "\"2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54378", "l": "diphosphate + nezukol => (+)-copalyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66516", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29537", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195926", "l": "Association with M1 at cell membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983671", "l": "OAS1 binds viral dsRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162836", "l": "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1445143", "l": "RAB8A,10,13,14 hydrolyze GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097216", "l": "guanosine tetraphosphate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852317", "l": "PLK1 phosphorylates GTSE1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679101", "l": "Defective ABCG8 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18746", "l": "2 juglone + O2 => 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-179421", "l": "Degradation of multiubiquitinated Nek2A (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210439", "l": "glutamate uptake by astrocytes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210439", "l": "glutamate uptake by astrocytes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29590", "l": "4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) <=> 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693061", "l": "STAMBP binds STAM (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38800", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50868", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5,12,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.9"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37293", "l": "L-alanine + L-leucine => H2O + L-alanyl-L-leucine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18442", "l": "D-dopachrome + H(+) => 5,6-dihydroxyindole + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692437", "l": "ANG binds F-actin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004846", "l": "urate oxidase activity"}, {"i": "MetaCyc:URATE-OXIDASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218812", "l": "FYN phosphorylates PAK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0048256", "l": "flap endonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.8", "l": "\"2,6-dioxo-6-phenylhexa-3-enoate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63162", "l": "(15Z)-tetracosenoate + taurine => H2O + N-(15Z-tetracosenoyl)-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987043", "l": "IL22RA1 binds JAK1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983422", "l": "Disassembly of COPII coated vesicle (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46823", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0003933", "l": "GTP cyclohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015420", "l": "ABC-type vitamin B12 transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875451", "l": "MET phosphorylates CBL (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047120", "l": "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21956", "l": "UDP-alpha-D-glucose + vitexin = H(+) + UDP + vitexin 2''-O-beta-D-glucoside"}, {"i": "EC:2.4.1.105", "l": "\"Vitexin beta-glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52996", "l": "[eIF5A protein]-N-(4-aminobutylidene)-L-lysine + H(+) + NADH = [eIF5A protein]-deoxyhypusine + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54594", "l": "a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate => a 5'-end diphospho-(purine-ribonucleoside) in mRNA + GTP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83791", "l": "Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31099", "l": "2-methylpropanoyl-CoA + FAD + H(+) = (2E)-2-methylpropenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350458", "l": "RHOGAPP190 activates GTP hydrolysis by RHO1:GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52027", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 <=> 18S-resolvin E2 + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60146", "l": "ADP + H(+) + L-gamma-glutamyl-L-glutamyl-[protein] + phosphate => ATP + L-glutamate + L-glutamyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990450", "l": "linear polyubiquitin binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047841", "l": "dehydrogluconokinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32163", "l": "ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine = AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine"}, {"i": "EC:6.3.2.38", "l": "\"N(2)-citryl-N(6)-acetyl-N(6)-hydroxylysine synthase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047105", "l": "4-trimethylammoniobutyraldehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50416", "l": "L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)"}, {"i": "EC:2.3.2.6", "l": "\"Lysine/arginine leucyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093327", "l": "EPHA binds TIAM1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17518", "l": "H2O + N-(long-chain-fatty-acyl)-L-glutamate => a long-chain fatty acid + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019164", "l": "pyruvate synthase activity"}, {"i": "EC:1.2.7.1", "l": "\"Pyruvate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12496", "l": "2 Fe(2+) + 4 H2O + O2 = 6 H(+) + H2O2 + 2 iron(III) oxide-hydroxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56412", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-ditetradecanoyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0017070", "l": "U6 snRNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9692880", "l": "HRH3 binds Hist (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22848", "l": "(3S)-hydroxyoctanedioyl-CoA + NAD(+) = 3-oxooctanedioyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391933", "l": "EP3 receptor can bind PGE2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37806", "l": "a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18820", "l": "acetyl-CoA + malonate <=> acetate + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730887", "l": "Autophosphorylation and activation of MEKK1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11881", "l": "(S)-6-hydroxynicotine + H2O + O2 => 6-hydroxypseudooxynicotine + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798372", "l": "ATM phosphorylates DYRK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40550", "l": "10-deoxymethymycin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + novamethymycin + 4 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110218", "l": "Cleavage of uracil by TDG glycosylase (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23885", "l": "nicotinamide + S-adenosyl-L-methionine => 1-methylnicotinamide + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352994", "l": "3-phosphoglycerate <=> 2-phosphoglycerate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38560", "l": "2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + tetracosanoate => (R)-2-hydroxytetracosanoate + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.194", "l": "\"Coniferyl-alcohol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60845", "l": "a 5'-end diphospho-guanosine in mRNA + GTP + H(+) => a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102623", "l": "scutellarein 7-methyl ether 6-O-methyltransferase activity"}, {"i": "MetaCyc:RXN-15528"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444661", "l": "HCAR2 binds HCAR2 ligands (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54674", "l": "(+)-kolavelool + diphosphate => (+)-kolavenyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043336", "l": "site-specific telomere resolvase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.26"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12130", "l": "2-oxoglutarate + 2 H(+) + L-glutamine + 2 reduced [2Fe-2S]-[ferredoxin] => 2 L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49542", "l": "(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate => (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173739", "l": "Spontaneous hydrolysis of C3 thioester (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865454", "l": "CBFB binds RUNX3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656211", "l": "MAP2Ks and MAPKs bind to the activated mutant RAF1 complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30572", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine => 6 AMP + 6 diphosphate + enterobactin + 4 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.350", "l": "\"Ureidoglycolate dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37961", "l": "(13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65252", "l": "(2E,6E)-farnesyl diphosphate + 6-hydroxymellein = diphosphate + verruculide C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19241", "l": "ent-kaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] = ent-7alpha-hydroxykaur-16-en-19-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37035", "l": "H2O + L-2-aminopentanoate + NAD(+) = 2-oxopentanoate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10777", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+) => 3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251562", "l": "Deletions in the AXIN1 gene prevent expression of AXIN1 protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9634834", "l": "ACHEIs bind ACHE (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36754", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose <=> beta-D-Gal-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.6"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11600", "l": "ATP + CMP = ADP + CDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018756", "l": "RHOH binds GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204813", "l": "Interaction of Tie2 and Grb14 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671707", "l": "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33296", "l": "L-hexahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-9-(methylsulfanyl)nonanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56103", "l": "[small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+) <=> [small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951676", "l": "RUNX3 binds TEADs and YAP1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4608855", "l": "PRICKLE1 is degraded by the proteasome (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62853", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45222", "l": "[Co(I) trimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M => [methyl-Co(III) trimethylamine-specific corrinoid protein] + coenzyme M"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39241", "l": "NADP(+) + triacontanoyl-CoA => (2E)-triacontenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18884", "l": "ATP + histamine + L-glutamate <=> ADP + H(+) + N(alpha)-gamma-L-glutamylhistamine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65937", "l": "beta-D-mannose => beta-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029471", "l": "Hydrolysis of PC to PA by PLD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35229", "l": "H(+)(in) + rifampicin(out) => H(+)(out) + rifampicin(in)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047009", "l": "3-alpha-hydroxy-5-beta-androstane-17-one 3-alpha-dehydrogenase activity"}, {"i": "RHEA:10356", "l": "3alpha-hydroxy-5beta-androstan-17-one + NAD(+) = 5beta-androstane-3,17-dione + H(+) + NADH"}, {"i": "EC:1.1.1.152", "l": "\"3-alpha-hydroxy-5-beta-androstane-17-one 3-alpha-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28469", "l": "pyridoxamine(in) <=> pyridoxamine(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47122", "l": "H2O + N-docosanoylglycine => docosanoate + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "88.206286499733196", "identifiers": [{"i": "GO:0032934", "l": "sterol binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14860", "l": "(indol-3-yl)acetate + ATP + L-lysine <=> ADP + H(+) + N(6)-[(indole-3-yl)acetyl]-L-lysine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803527", "l": "ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44606", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54857", "l": "H(+) + NADPH + O2 + octan-3-one => ethyl hexanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202137", "l": "AKT1 binds eNOS complex via HSP90 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158313", "l": "factor XII -> factor XIIa (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801109", "l": "CHM binds RGGT (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26517", "l": "cyclohexan-1,2-dione + H2O <=> 6-oxohexanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801089", "l": "TP53 stimulates RABGGTA expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37449", "l": "H(+) + H2O + tetracenomycin D3 => O2 + tetracenomycin F1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678920", "l": "TLR processing at low pH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25430", "l": "ADP + H(+) + N-acetyl-alpha-D-hexosamine 1-phosphate => ATP + N-acetyl-D-hexosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42411", "l": "(2R)-2-phosphoglycerate + ATP <=> (2R)-2,3-bisphosphoglycerate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34620", "l": "1-deoxypentalenate + 2-oxoglutarate + O2 => 1-deoxy-11beta-hydroxypentalenate + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5138432", "l": "DVL2 is phosphorylated by PKC (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32690", "l": "(2E)-geranyl diphosphate <=> diphosphate + tricyclene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473596", "l": "Collagen type I degradation by MMP15 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27648", "l": "alpha-D-ribose 1-phosphate + hypoxanthine => inosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944483", "l": "miR-17 microRNA binds PTEN mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693012", "l": "TNFSF15 binds TNFRSF25 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47780", "l": "a cytidine in 25S rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in 25S rRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61512", "l": "malvidin + UDP-alpha-D-glucose = malvidin 3-O-beta-D-glucoside + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624798", "l": "LBR binds KPNB1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694462", "l": "ABHD6,12 hydrolyse 3AG (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51301", "l": "(9Z)-octadecenoate + L-phenylalanine => H2O + N-(9Z-octadecenoyl)-L-phenylalanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10859", "l": "a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose <=> a 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphing-4-enine + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21884", "l": "H2O + trithionate = H(+) + sulfate + thiosulfate"}, {"i": "EC:3.12.1.1", "l": "\"Trithionate hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60825", "l": "H2O + P(1),P(2)-bis(5'-adenosyl) diphosphate => 2 AMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61602", "l": "[DsbB protein]-dithiol + [protein]-disulfide => [DsbD protein]-disulfide + [protein]-dithiol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445064", "l": "Activation of Rac1 by VAV2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709406", "l": "CO binds to Cytochrome c oxidase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-994148", "l": "LRRC16A binds F-actin capping protein (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68637", "l": "CDC6 protein is synthesized under the control of E2F transcription factors (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75081", "l": "Formation of AT-AC B Complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42628", "l": "S-adenosyl-L-methionine + uridine(747) in 23S rRNA = 5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.189", "l": "\"23S rRNA (uracil(747)-C(5))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9639286", "l": "RRAGC,D exchanges GTP for GDP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14079", "l": "beta-alanine + pyruvate => 3-oxopropanoate + L-alanine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202437", "l": "Phosphorylation of CARMA1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13429", "l": "2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate"}, {"i": "EC:2.7.7.60", "l": "\"2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451033", "l": "(S)-Malate <=> Fumarate + H2O (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070746", "l": "interleukin-35 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9709098", "l": "DHFR dimer reduces FOLA to DHF (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40648", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36561", "l": "4-hydroxy-1-pyrroline-2-carboxylate + AH2 + H(+) => A + cis-4-hydroxy-D-proline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163069", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.10"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432148", "l": "Fgr may phosphorylate p38 MAPK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50216", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10713", "l": "L-phenylalanine + O2 => 2-phenylacetamide + CO2 + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31086", "l": "H2O + N-acetyl-D-muramoyl-L-alanine <=> L-alanine + N-acetyl-D-muramate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043857", "l": "N-acetylornithine carbamoyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008792", "l": "arginine decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31071", "l": "(S)-methylmalonate semialdehyde + L-alanine = (S)-3-amino-2-methylpropanoate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374664", "l": "Phosphorylation and activation of Ezrin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33093", "l": "2-demethylmenaquinol-8 + CO2 + diphosphate => 1,4-dihydroxy-6-naphthoate + all-trans-octaprenyl diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62818", "l": "2 dinapinone E + 2 H2O => 4 monapinone E + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54630", "l": "2-hydroxydodecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + dodecanoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70971", "l": "citrate <=> isocitrate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20536", "l": "H2O + pyridoxal 5'-phosphate <=> phosphate + pyridoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46690", "l": "3-oxo-cholest-4,24-dien-26-oyl-CoA + AH2 => (25S)-3-oxocholest-4-en-26-oyl-CoA + A"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49893", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2 => (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30065", "l": "H(+) + menaquinol-8 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-8 + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62605", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => 7-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58407", "l": "hexan-1-ol + NADP(+) <=> H(+) + hexanal + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210289", "l": "Recruitment of SYK to p-DAP12 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848930", "l": "PTK6 translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13111", "l": "H(+) + N-hydroxy-2-acetamidofluorene + NADH => 2-acetamidofluorene + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15428", "l": "coproporphyrinogen III + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38797", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802916", "l": "RAF is phosphorylated downstream of moderate kinase activity BRAF mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161791", "l": "15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38230", "l": "(9Z)-octadecenoyl-CoA + hexadecan-1-ol <=> CoA + hexadecanyl (9Z)-octadecenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35322", "l": "H(+) + malonyl-CoA + octadecanoyl-CoA <=> 3-oxoeicosanoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63998", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21833", "l": "3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine => 3',5-dihydroxy-3,4',7-trimethoxyflavone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62980", "l": "(9Z)-hexadecenamide + H2O = (9Z)-hexadecenoate + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61302", "l": "acetaldehyde + dihydroxyacetone phosphate => 5-deoxy-D-ribulose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30922", "l": "A + rhodopin <=> (3E)-3,4-didehydrorhodopin + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690152", "l": "USP5 cleaves polyubiquitin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11765", "l": "H2O + methylguanidine => methylamine + urea"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989773", "l": "Expression of CPT2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29154", "l": "3 a ubiquinol(in) + 2 H(+)(out) + nitrite(out) <=> 3 a ubiquinone(in) + 2 H2O(out) + NH4(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28881", "l": "H(+)(out) + L-tryptophan(out) => H(+)(in) + L-tryptophan(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2327746", "l": "FN1 aggregation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950456", "l": "IL12B dimerizes (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39276", "l": "(2E,15Z)-tetracosadienoyl-CoA + H(+) + NADPH => (15Z)-tetracosenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20021", "l": "2-oxoglutarate + deoxyamidinoproclavaminate + O2 = amidinoproclavaminate + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18799", "l": "a 3',5'-dihydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 3'-hydroxy,5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661419", "l": "ALB binds extracellular heme (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17347", "l": "CoA + H(+) + methylmalonate => (S)-methylmalonyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-877187", "l": "P2X7 mediates loss of intracellular K+ (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18880", "l": "myo-inositol + S-adenosyl-L-methionine <=> 1D-3-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16440", "l": "glutathione + RX <=> a halide anion + an S-substituted glutathione + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202111", "l": "AKT1 phosphorylates eNOS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49469", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-6-sulfoquinovose => a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034011", "l": "L-cysteate sulfo-lyase activity"}, {"i": "KEGG.REACTION:R07634"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.105", "l": "\"L-tryptophan decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34728", "l": "H2O + N-acyl-15-methylhexadecasphinganine => 15-methylhexadecasphinganine + a carboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709406", "l": "CO binds to Cytochrome c oxidase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5591086", "l": "SERPINA5 binds activated protein C (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050257", "l": "riboflavin phosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6783670", "l": "CRLF1 binds CLCF1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71495", "l": "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35087", "l": "H2O + N'-monoacetylchitobiose-6'-phosphate = D-glucosamine + N-acetyl-D-glucosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "74.836269892493803", "identifiers": [{"i": "GO:0042562", "l": "hormone binding"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0042294", "l": "URM1 transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16009", "l": "ATP + formate = ADP + formyl phosphate"}, {"i": "EC:2.7.2.6", "l": "\"Formate kinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0033229", "l": "cysteine transmembrane transporter activity"}, {"i": "RHEA:32795", "l": "ATP + H2O + L-cysteine(out) = ADP + H(+) + L-cysteine(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16567", "l": "3-(imidazol-5-yl)pyruvate + L-glutamate => 2-oxoglutarate + L-histidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31028", "l": "2-trans-(+)-abscisate + UDP-alpha-D-glucose => beta-D-glucopyranosyl trans-(+)-abscisate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2730872", "l": "Activation of Calcineurin (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13179", "l": "3-oxopropanoate + dihydroxyacetone phosphate => 6-phospho-5-dehydro-2-deoxy-D-gluconate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351849", "l": "Caspase-mediated cleavage of Etk (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22117", "l": "luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP-alpha-D-glucuronate => H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] 4'-O-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60868", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O = a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(7)-methyl-GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47278", "l": "15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8856157", "l": "LAG3 (CD233) binds MHC II (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31529", "l": "(S)-1-pyrroline-5-carboxylate + guanidine + H(+) + H2O => N(omega)-hydroxy-L-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27335", "l": "2,5-dihydroxypyridine + CO2 + H2O + NAD(+) => 6-hydroxynicotinate + 2 H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55327", "l": "11-cis-retinol + hexadecanoyl-CoA <=> 11-cis-retinyl hexadecanoate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045515", "l": "interleukin-18 receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18170", "l": "4-hydroxy-2-oxoglutarate => glyoxylate + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72647", "l": "Cap-bound mRNA is activated by helicases  (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36340", "l": "[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine => 2-thio-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13571", "l": "beta-D-GalNAc-(1->4)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer + H(+) + UDP => ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23024", "l": "[(1->4)-beta-D-glucosyl](n) + phosphate = [(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate"}, {"i": "EC:2.4.1.49", "l": "\"Cellodextrin phosphorylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17854", "l": "keto-L-sorbose + O2 => 5-dehydro-D-fructose + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11611", "l": "[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA <=> [(2->8)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63197", "l": "(10bR,4aS)-noroxomaritidine + H(+) + NADPH => (10bR,4aS)-oxomaritidine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32492", "l": "(1E,4E,8E)-alpha-humulene + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxy-alpha-humulene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31533", "l": "CO2 + N(omega)-hydroxy-L-arginine + succinate => 2-oxoglutarate + L-arginine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381109", "l": "IRE1 binds IRE1 forming dimer (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21241", "l": "geranylgeranyl diphosphate + L-cysteinyl-[protein] => diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749197", "l": "ORC1 binds to H4K20me2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66086", "l": "H2O + kynurenate + L-aspartate => L-kynurenine + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874187", "l": "MBTPS2 (S2P) cleaves CREB3L2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15224", "l": "a CDP-1,2-diacyl-sn-glycerol + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27461", "l": "D-glycero-alpha-D-manno-heptose 1-phosphate + GTP + H(+) = diphosphate + GDP-D-glycero-alpha-D-manno-heptose"}, {"i": "EC:2.7.7.71", "l": "\"D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427528", "l": "Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14713", "l": "A + keto-L-sorbose = 5-dehydro-D-fructose + AH2"}, {"i": "EC:1.1.99.12", "l": "\"Sorbose dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54767", "l": "5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine <=> [LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654637", "l": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77094", "l": "Formation of cap binding complex (CBC) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814555", "l": "Integrator complex processes the 3' end of snRNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77077", "l": "Capping complex formation (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070338", "l": "5'-flap-structured DNA binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41496", "l": "1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37010", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209921", "l": "Monoiodinated tyrosine can be deiodinated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-532549", "l": "MPI isomerises Fru6P to Man6P (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "67.708239083454572", "identifiers": [{"i": "GO:0035251", "l": "UDP-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034634", "l": "glutathione transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "86.870262171526278", "identifiers": [{"i": "GO:0005350", "l": "pyrimidine nucleobase transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14690", "l": "4-chlorophenylacetate + NADH + O2 => 3,4-dihydroxyphenylacetate + chloride + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158860", "l": "SULT1A1 dimer sulfonates NHABP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428752", "l": "Dissociation of the TP:Gq complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1067667", "l": "IL6 binds IL6R (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451826", "l": "YKI binds to EX (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53333", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 => 2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15806", "l": "(7R,8S)-7,8-diammoniononanoate + ATP + CO2 => (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63954", "l": "a sphingoid base + phosphate => a sphingoid 1-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4411402", "l": "Activation of NLK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12687", "l": "H(+) + mycothione + NADPH => 2 mycothiol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11919", "l": "13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) <=> 15-oxoprostaglandin E2 + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190245", "l": "FGFR1b binds to FGF (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362549", "l": "Hh-Np traffics to the plasma membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804100", "l": "HMGB1 binds LPS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-947535", "l": "Cyclisation of GTP to precursor Z (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909724", "l": "Recruitment of IFNAR1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807214", "l": "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52575", "l": "butanoyl-CoA + NAD(+) <=> (2E)-butenoyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047335", "l": "3-phosphoglyceroyl-phosphate-polyphosphate phosphotransferase activity"}, {"i": "RHEA:18665", "l": "(2R)-3-phospho-glyceroyl phosphate + [phosphate](n) = (2R)-3-phosphoglycerate + [phosphate](n+1)"}, {"i": "EC:2.7.4.17", "l": "\"3-phosphoglyceroyl-phosphate--polyphosphate phosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981353", "l": "RASA1 stimulates RAS GTPase activity (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17657", "l": "an acyl-CoA + dihydroxyacetone phosphate = a 1-acylglycerone 3-phosphate + CoA"}, {"i": "EC:2.3.1.42", "l": "\"Glycerone-phosphate O-acyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44784", "l": "2-demethylmenaquinol-10 + S-adenosyl-L-methionine = H(+) + menaquinol-10 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205231", "l": "Dimerization of KIT upon SCF binding (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-481010", "l": "Surface deployment of platelet dense granule membrane components (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14497", "l": "A + pyridoxine = AH2 + isopyridoxal"}, {"i": "EC:1.1.99.9", "l": "\"Pyridoxine 5-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004482", "l": "mRNA (guanine-N7-)-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030377", "l": "urokinase plasminogen activator receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419003", "l": "Interaction of Nectins with Afadin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632182", "l": "PRMT1 methylates ESRs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.25"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35691", "l": "(2S)-versicolorone + NADP(+) = 1'-hydroxyversicolorone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64951", "l": "dCTP + H2O <=> dCDP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45956", "l": "(9Z)-octadecenoyl-CoA(in) = (9Z)-octadecenoyl-CoA(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62407", "l": "(R)-2-hydroxyhexadecanoate + O2 <=> CO2 + H2O + pentadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42639", "l": "AH2 + L-cysteine + Mo-molybdopterin <=> A + H2O + L-alanine + thio-Mo-molybdopterin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937029", "l": "IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37259", "l": "(2S)-2-aminobutanoate + H2O + NAD(+) = 2-oxobutanoate + H(+) + NADH + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913451", "l": "IL3RB is phosphorylated on Ser-585 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67121", "l": "N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804253", "l": "MDM2 ubiquitinates JMY (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2468040", "l": "Cohesin binds PDS5 and WAPAL (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46613", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol => (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031741", "l": "type B gastrin/cholecystokinin receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36147", "l": "acetyl-CoA + benzyl alcohol = benzyl acetate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29460", "l": "beta-alanine(in) + H(+)(in) => beta-alanine(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635845", "l": "GLI proteins bind CDC73 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693540", "l": "MRN activates ATM (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247844", "l": "WNT ligands traffic to the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12806", "l": "(S)-canadine + S-adenosyl-L-methionine => (S)-N-methylcanadine + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17728", "l": "(2S,3S)-2-methylcitrate <=> 2-methyl-cis-aconitate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28670", "l": "H(+) + hydroxyacetone + NADH <=> (S)-propane-1,2-diol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35885", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61354", "l": "ADP + H(+) + phosphate + riboflavin(out) => ATP + H2O + riboflavin(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24444", "l": "GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[(1->4)-alpha-L-Fuc]-beta-D-GlcNAc}-L-asparaginyl-[protein]"}, {"i": "EC:2.4.1.214", "l": "\"Glycoprotein 3-alpha-L-fucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1028820", "l": "Formation of VAF (virus-activated factor) complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856945", "l": "PP2A methylation by LCMT1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27712", "l": "ADP + GMP + H(+) => ATP + guanosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395320", "l": "Latent TGF-beta-1 binds integrins (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23308", "l": "(E)-sinapoyl-CoA + D-glucarate = 2-O-[(E)-sinapoyl]-D-glucarate + CoA"}, {"i": "EC:2.3.1.131", "l": "\"Glucarate O-hydroxycinnamoyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004340", "l": "glucokinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682544", "l": "nsp14 binds nsp10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31310", "l": "alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate <=> alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3965450", "l": "DAAM1 recruits PFN1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5623643", "l": "RDH13 reduces atRAL to atROL (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004307", "l": "ethanolaminephosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52887", "l": "H2O + N-phenylhydroxylamine + 2 NADP(+) <=> 2 H(+) + 2 NADPH + nitrobenzene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388811", "l": "CD28 homodimer binds B7-1 homodimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75172", "l": "Formation of RAD50:MRE11 complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36976", "l": "AMP + phosphate => adenine + alpha-D-ribose 1,5-bisphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647660", "l": "GSDME (1-270) binds PIPs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11686", "l": "dimethylarsinate + 2 H(+) + S-adenosyl-L-homocysteine => methylarsonous acid + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9648089", "l": "NEK6 and NEK7 phosphorylate EML4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34087", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + cholesterol = a 1-acyl-sn-glycero-3-phosphocholine + a cholesterol ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10679", "l": "(2R,3S)-3-isopropylmalate <=> 2-isopropylmaleate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54717", "l": "N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52215", "l": "acetochlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> ethyl formate + H2O + N-(2-ethyl-6-methylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191072", "l": "Synthesis of Cx43 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113429", "l": "Elongating transcript encounters a lesion in the template (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227775", "l": "TRAF6/or TRAF2 interacts with IPS-1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201608", "l": "Caspase-mediated cleavage of alpha adducin (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-984671", "l": "Chromokinesins form dimers (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21303", "l": "H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine <=> a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928625", "l": "PAKs autophosphorylate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-114684", "l": "Phosphorylation of Syntaxin-4 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034520", "l": "2-naphthaldehyde dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45591", "l": "a long-chain fatty acid + ATP + holo-[ACP] <=> a long-chain fatty acyl-[ACP] + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48120", "l": "ganglioside GD3 + H2O = ganglioside GM3 + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47830", "l": "ganglioside GD1b + N-acetylneuraminate => ganglioside GT1b + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.17", "l": "\"Lysozyme\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47687", "l": "[(1->2)-beta-D-glucosyl](n) + phosphate <=> [(1->2)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72663", "l": "De novo formation of eIF2:GTP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0000009", "l": "alpha-1,6-mannosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693783", "l": "NAALADases hydrolyse NAAG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851352", "l": "CCR8 binds CCL1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.396", "l": "\"Bacteriochlorophyllide-a dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.62"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48192", "l": "(9E)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9E)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047741", "l": "cetraxate benzylesterase activity"}, {"i": "RHEA:23460", "l": "benzyl cetraxate + H2O = benzyl alcohol + cetraxate + H(+)"}, {"i": "EC:3.1.1.70", "l": "\"Cetraxate benzylesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4549382", "l": "Defective ALG1 does not transfer the first Man to the N-glycan precursor (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46660", "l": "H(+) + NADPH + progesterone = 5beta-pregnan-3,20-dione + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36111", "l": "gibberellin A1 + S-adenosyl-L-methionine = O-methyl gibberellin A1 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56329", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + H2O => 5'-triphosphoadenylyl-(2'->5')-adenosine + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16643", "l": "a long-chain fatty acid + ethanol + H(+) => a long-chain fatty acyl ethyl ester + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64225", "l": "AH2 + O2 + uridine(34) in tRNA => 5-hydroxyuridine(34) in tRNA + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50006", "l": "11a-hydroxytetracycline + H2O + NADP(+) => H(+) + NADPH + O2 + tetracycline"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40568", "l": "AH2 + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + O2 => A + dTDP-beta-L-evernitrose + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941411", "l": "OSCN- reacts with Cys residues (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57261", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP => GDP + H(+) + lactate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210285", "l": "Trans-homophilic interaction of PECAM-1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018820", "l": "cyanamide hydratase activity"}, {"i": "MetaCyc:CYANAMIDE-HYDRATASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5695964", "l": "ABHD14B hydrolyses PNPB (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2214330", "l": "Cleavage of collagen VII NC2 region by BMP1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0008297", "l": "single-stranded DNA exodeoxyribonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77077", "l": "Capping complex formation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34938", "l": "2 ATP + H(+) <=> diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45208", "l": "[methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M = [Co(I) methanol-specific corrinoid protein] + H(+) + methyl-coenzyme M"}, {"i": "EC:2.1.1.246", "l": "\"[Methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48774", "l": "3-deacetyl-3-vinylbacteriochlorophyllide a + H2O => 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57214", "l": "N(2)-(1-hydroxy-2-oxopropyl)-dGTP => dGTP + methylglyoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664867", "l": "NBR1 binds MAP1LC3B (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157632", "l": "Complex of NOTCH1 with its ligand is cleaved to produce NEXT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37321", "l": "ADP + glycyl-L-methionine(in) + H(+) + phosphate => ATP + glycyl-L-methionine(out) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56582", "l": "6-methylthioguanine + H(+) + S-adenosyl-L-homocysteine => 6-thioguanine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.72"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.5"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429732", "l": "multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090729", "l": "toxin activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17983", "l": "cortisone + H(+) + NADPH => 4,5alpha-dihydrocortisone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879221", "l": "PSTPIP1 binds Pyrin (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70501", "l": "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029270", "l": "Recruitment of PLCgamma to membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201608", "l": "Caspase-mediated cleavage of alpha adducin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875374", "l": "MET binds LRIG1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51549", "l": "(R)-tetrahydropapaverine + S-adenosyl-L-methionine => (R)-N-methyltetrahydropapaverine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103071", "l": "2-hydroxy-3-methyl-branched 2,3,4-saturated fatty acyl-CoA lyase activity"}, {"i": "MetaCyc:RXN66-471"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50294", "l": "all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin] => all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.71", "l": "\"Adenosine-5'-diphospho-5'-(DNA) diphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42497", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate => 10-deacetyl-2-debenzoylbaccatin III"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15470", "l": "1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide => 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62741", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) => 1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2545203", "l": "Deacetylation of cleaved cohesin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3364026", "l": "SET1 complex trimethylates H3K4 at the MYC gene (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56489", "l": "O2 + oleanolate + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + hederagenin + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46316", "l": "GDP-N,N'-diacetylbacillosamine + H2O = 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932327", "l": "NFE2L2 binds KEAP1:CUL3:RBX1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428273", "l": "SPHK1 phosphorylates SPG to S1P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35537", "l": "cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2 => cyclo(L-phenylalanyl-L-leucyl) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54654", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => peregrinol diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17860", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taurochenodeoxycholate <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taurohyocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336422", "l": "Clathrin-mediated endocytosis of DT:HBEGF:CD9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55371", "l": "(R)-carnitine + H(+) + NADPH + O2 <=> (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50344", "l": "3 (S)-methylmalonyl-CoA + a long-chain fatty acyl-CoA + 9 H(+) + holo-[mycolipanoate synthase] + 6 NADPH = 3 CO2 + 4 CoA + 3 H2O + long-chain mycolipanoyl-[mycolipanoate synthase] + 6 NADP(+)"}, {"i": "EC:2.3.1.252", "l": "\"Mycolipanoate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689111", "l": "PARK2 autoubiquitinates (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42513", "l": "5-acetamidopentanoate + H2O => 5-aminopentanoate + acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70482", "l": "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49596", "l": "an N-acylsphing-4-enine + UDP-alpha-D-galactose = H(+) + N-acyl-D-galactosylsphing-4-enine + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "74.836269892493803", "identifiers": [{"i": "GO:0070851", "l": "growth factor receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64061", "l": "(S)-phenylacetylcarbinol + NAD(+) => 1-phenyl-1,2-propanedione + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51436", "l": "acetyl-CoA + D-alanine = (2R)-2-amino-4-oxopentanoate + CoA"}, {"i": "EC:2.3.1.263", "l": "\"2-amino-4-oxopentanoate thiolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23431", "l": "3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23393", "l": "(nucleoside 5'-monophosphate)n + (n-1) H2O => n a ribonucleoside 5'-phosphate + n H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730888", "l": "Phosphorylation of PLC-gamma (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55636", "l": "ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63702", "l": "mycophenolic acid O-acyl-beta-D-glucuronide + UDP => mycophenolate + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62016", "l": "L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP"}, {"i": "EC:2.4.2.63", "l": "\"EGF-domain serine xylosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102872", "l": "1-16:0-2-18:2-phosphatidylcholine desaturase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58217", "l": "A + dihydroserpentine => AH2 + serpentine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2750177", "l": "Syndecan-2 binds TRAPPC4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0016649", "l": "oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor"}, {"i": "EC:1.5.5.-", "l": "\"With a quinone or similar compound as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800797", "l": "The PIDDosome activates CASP2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60446", "l": "an S-substituted L-cysteine + glycine => an S-substituted L-cysteinylglycine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55724", "l": "17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] = 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203611", "l": "N-myristoylation of eNOS (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27964", "l": "H(+) + pyrroloquinoline quinol + scyllo-inosose => myo-inositol + pyrroloquinoline quinone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70420", "l": "HK1,2,3,GCK phosphorylate Glc to form G6P (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849094", "l": "ARHGAP35 binds RASA1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204392", "l": "Basigin binds MCT1, MCT3 and MCT4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800380", "l": "PTPRD binds IL1RAP-1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54286", "l": "H(+) + N-octadecanoylsphing-4-enine + phosphocholine => H2O + N-(octadecanoyl)-sphing-4-enine-1-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60081", "l": "4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2 => 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37393", "l": "1-(9Z)-octadecaenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA => (9Z,12Z)-octadecadienoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12538", "l": "CO2 + H2O + L-phenylalanine => H(+) + L-arogenate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047387", "l": "serine-ethanolaminephosphate phosphodiesterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20321", "l": "L-proline + NAD(+) = 1-pyrroline-2-carboxylate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38960", "l": "a 2,3-saturated acyl-CoA + O2 => a (2E)-enoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13081", "l": "biotin amide + H2O = biotin + NH4(+)"}, {"i": "EC:3.5.1.12", "l": "\"Biotinidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36788", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-galactosamine => N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048027", "l": "mRNA 5'-UTR binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43193", "l": "cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine => 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27348", "l": "FMNH2 + O2 <=> 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49333", "l": "2-hydroxyspheroidene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2,2-dihydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58903", "l": "1-carboxybiuret + H2O <=> NH4(+) + urea-1,3-dicarboxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59303", "l": "3'-phosphoadenylyl sulfate + firefly D-luciferin <=> adenosine 3',5'-bisphosphate + firefly D-sulfoluciferin + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788622", "l": "p-Y-STATs dimerize (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63923", "l": "octadecanoyl-CoA + sphinga-4E,14Z-dienine <=> CoA + H(+) + N-octadecanoyl-sphinga-4E,14Z-dienine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11406", "l": "UDP-alpha-D-galacturonate => UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24481", "l": "a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O => a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22928", "l": "4-acetamidobutanoyl-CoA + H2O = 4-aminobutanoyl-CoA + acetate"}, {"i": "EC:3.5.1.51", "l": "\"4-acetamidobutyryl-CoA deacetylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37069", "l": "2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => [sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28730", "l": "Cu(2+)(in) + H(+)(in) <=> Cu(2+)(out) + H(+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-165162", "l": "Phosphorylation of TSC2 by PKB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683774", "l": "p-T68-CHEK2 dimerizes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032562", "l": "dAMP binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25780", "l": "H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine = 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate"}, {"i": "EC:1.1.1.336", "l": "\"UDP-N-acetyl-D-mannosamine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379387", "l": "COMT transfers Met to DA to form 3MT (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015663", "l": "nicotinamide mononucleotide transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983161", "l": "Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9725206", "l": "IgE binds FCERI (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28362", "l": "dGTP + H2O = dGMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19851", "l": "ADP-D-ribose 2'-phosphate + H(+) + nicotinamide => H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26441", "l": "3-hydroxypropanoate + NADP(+) <=> 3-oxopropanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35391", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA = (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174445", "l": "RPA binds to the Flap on the C-strand (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6802973", "l": "PLK3 phosphorylates CDC25C (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10852", "l": "dimethylallyl diphosphate + leachianone G = diphosphate + sophoraflavanone G"}, {"i": "EC:2.5.1.71", "l": "\"Leachianone-G 2''-dimethylallyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-349426", "l": "Phosphorylation of MDM4 by CHEK2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47696", "l": "(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + H2O = (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174157", "l": "Degradation of multiubiquitinated Cyclin B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033854", "l": "glutamate-prephenate aminotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.99.-", "l": "\"Other carbon-nitrogen lyases\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63474", "l": "ADP + all-trans-hexaprenyl phosphate + H(+) => all-trans-hexaprenol + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61034", "l": "5-hydroxy-3,7,3',4'-tetramethoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163625", "l": "Glucagon binds to Glucagon receptor (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109857", "l": "MAP2K1 binds MAPK3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005047", "l": "signal recognition particle binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706399", "l": "RHOBTB3 hydrolyzes ATP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785898", "l": "IL4R binds JAK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9696275", "l": "RND2 binds GTP (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11258", "l": "glucosyl-limonin + 2 H(+) + UDP => H2O + limonin + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20355", "l": "AH2 + tetrachloroethene => A + chloride + H(+) + trichloroethene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44214", "l": "3-hydroxytetradecanoyl-CoA + AMP + diphosphate => 3-hydroxytetradecanoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417842", "l": "P2Y10 receptor can bind to LPA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43976", "l": "H(+) + hexadecanoate + NADPH + O2 = 14-hydroxyhexadecanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692768", "l": "MAPKAPK5 phosphorylates KALRN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31586", "l": "2-hydroxy-dATP + H2O <=> 2-hydroxy-dAMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10213", "l": "2-oxoglutarate + 5-aminopentanoate => 5-oxopentanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192123", "l": "CYP27A1 27-hydroxylates CHOL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17367", "l": "ADP + H(+) + Mn(2+)(in) + phosphate => ATP + H2O + Mn(2+)(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55027", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610723", "l": "GLI proteins bind SUFU (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35801", "l": "7,8-dihydroneopterin 3'-phosphate + H(+) => 7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44280", "l": "2 H(+) + 2 malonyl-CoA + octadecanoyl-CoA = 4-hydroxy-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972966", "l": "POU5F1 (OCT4), SOX2, NANOG bind the HHEX promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11362", "l": "2 aureusidin + 2 H2O => 2 2',3,4,4',6'-pentahydroxychalcone + 2 H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853800", "l": "ARTN binds RET:GFRA1,GFRA3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30521", "l": "diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine => GTP + H(+) + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0055103", "l": "ligase regulator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28244", "l": "5-hydroxypseudobaptigenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => O2 + pratensein + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047201", "l": "beta-glucogallin O-galloyltransferase activity"}, {"i": "KEGG.REACTION:R00049"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10147", "l": "a ribonucleoside 3'-phosphate + H2O <=> a ribonucleoside + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102283", "l": "3-ketodihydrosphinganine (C20) reductase activity"}, {"i": "MetaCyc:RXN-12642"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879266", "l": "mycothiol is oxidized to mycothione (Mycobacterium tuberculosis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15210", "l": "(2R,3R)-tartrate + NAD(+) => 2-hydroxy-3-oxosuccinate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.17", "l": "\"Calcium/calmodulin-dependent protein kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50396", "l": "(2-aminobenzoyl)acetate + H(+) + octanoyl-CoA = 2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O"}, {"i": "EC:2.3.1.230", "l": "\"2-heptyl-4(1H)-quinolone synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614605", "l": "Persulfide sulfur is dioxygenated (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42142", "l": "a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19114", "l": "(8Z,11Z,14Z)-heptadecatrienal + A + H2O => (8Z,11Z,14Z)-heptadecatrienoate + AH2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55391", "l": "(3R)-3-hydroxy-2,3-dihydrotabersonine + A <=> (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57688", "l": "apo-[corrinoid adenosyltransferase] + cob(II)inamide = cob(II)inamide--[corrinoid adenosyltransferase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036217", "l": "dGTP diphosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357479", "l": "p-AXL binds PI3K (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48172", "l": "ganglioside GM2 + H2O = N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetylneuraminate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004848", "l": "ureidoglycolate hydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32639", "l": "(6E)-8-hydroxylinalool + O2 + reduced [NADPH--hemoprotein reductase] = (6E)-8-oxolinalool + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35041", "l": "spermidine(out) => spermidine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734730", "l": "ORC1 translocates to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168638", "l": "Activated IKK phosphorylates I-kappaB (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66625", "l": "cholest-4-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => (25S)-3-oxocholest-4-en-26-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050441", "l": "3-ethylmalate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54264", "l": "2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2 = (3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate"}, {"i": "EC:1.14.11.n4", "l": "\"Ankyrin-repeat-histidine dioxagenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20289", "l": "acetyl-CoA + H2O = acetate + CoA + H(+)"}, {"i": "EC:3.1.2.1", "l": "\"Acetyl-CoA hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11762", "l": "4 ADP + aerobactin + 4 H(+) + 4 phosphate => 4 ATP + citrate + 2 H2O + 2 N(6)-acetyl-N(6)-hydroxy-L-lysine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45741", "l": "2-oxoglutarate + L-ectoine + O2 => 5-hydroxyectoine + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62416", "l": "(E)-4-coumaroyl-CoA + H2O = 4-hydroxybenzaldehyde + acetyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42977", "l": "L-tryptophan => 2-aminoprop-2-enoate + indole"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638006", "l": "ARL3 hydrolyzes GTP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046509", "l": "1,2-diacylglycerol 3-beta-galactosyltransferase activity"}, {"i": "RHEA:14945", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose = a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + UDP"}, {"i": "EC:2.4.1.46", "l": "\"Monogalactosyldiacylglycerol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12773", "l": "2-oxoglutarate + O2 + proclavaminate = CO2 + dihydroclavaminate + H2O + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.1", "l": "\"Exodeoxyribonuclease I\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167408", "l": "The high affinity receptor complex binds to G-protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23974", "l": "(2E)-butenoyl-CoA + CO2 + Na(+)(out) => (2E)-glutaconyl-CoA + H(+) + Na(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54063", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (2Z,6E)-hedycaryol + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14521", "l": "(2E)-geraniol + NADP(+) = (2E)-geranial + H(+) + NADPH"}, {"i": "EC:1.1.1.183", "l": "\"Geraniol dehydrogenase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46346", "l": "3-oxo-2-methylhexadecanoyl-CoA + CoA => propanoyl-CoA + tetradecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32479", "l": "2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + H(+) + 2 NADPH"}, {"i": "EC:1.21.1.1", "l": "\"Iodotyrosine deiodinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1861789", "l": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27762", "l": "CTP + H2O = CMP + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018847", "l": "alpha-pinene lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27449", "l": "a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate"}, {"i": "EC:3.1.3.81", "l": "\"Diacylglycerol diphosphate phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37301", "l": "L-alanine + L-threonine => H2O + L-alanyl-L-threonine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50113", "l": "octadecanoyl-CoA + taurine => CoA + H(+) + N-octadecanoyl-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848023", "l": "Activated PTK6 binds STAP2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850997", "l": "TRIM27 binds PTEN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35513", "l": "glycyrrhetinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => glycyrrhetaldehyde + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030184", "l": "nitric oxide transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50808", "l": "glutathione + prostaglandin J2 = prostaglandin J2-S-(S)-glutathione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13844", "l": "[transferrin[Fe(II)2]] + H(+) + NAD(+) <=> [transferrin[Fe(III)2]] + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58402", "l": "H(+) + heptanal + NADPH => heptan-1-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30865", "l": "L-tyrosine + phosphate => 4-O-phospho-L-tyrosine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130504", "l": "Cleavage of lip22 to lip10 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.46", "l": "\"L-peptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17696", "l": "deoxycholoyl-CoA + H2O <=> CoA + deoxycholate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008874", "l": "gluconate 5-dehydrogenase activity"}, {"i": "MetaCyc:GLUCONATE-5-DEHYDROGENASE-RXN"}, {"i": "EC:1.1.1.69", "l": "\"Gluconate 5-dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671737", "l": "p-T774-PKN1 binds CDC25C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668395", "l": "CHMP7 binds CC2D1B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.27"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24937", "l": "N-formimidoylglycine => H2O + imidazol-4-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.15"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34514", "l": "N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine <=> H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40969", "l": "(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63263", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H(+) + NADH <=> 4-pyridoxate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186785", "l": "PDGF-AA clevage by Furin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57232", "l": "GDP + methylglyoxal = N(2)-(1-hydroxy-2-oxopropyl)-GDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50368", "l": "2-methylbutan-2-ol + H(+) + NADPH + O2 = 3-hydroxy-3-methylbut-1-ene + 2 H2O + NADP(+)"}, {"i": "EC:1.14.19.48", "l": "\"Tert-amyl alcohol desaturase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700998", "l": "BAP1 disrupts the BRCA1:BARD1 heterodimer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102115", "l": "peptidoglycan asparagine synthase activity"}, {"i": "MetaCyc:RXN-11338"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57480", "l": "2-hydroxydodecanoate + H2O2 = 2,3-dihydroxydodecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692408", "l": "NPR2 binds NPPC (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47804", "l": "epothilone C + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = epothilone A + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62704", "l": "glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352059", "l": "SLC6A15-mediated amino acid uptake (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9670101", "l": "ATRX:DAXX binds to subtelomeric chromosomal regions (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6810376", "l": "ING2 binds PI5P (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371554", "l": "HSF1 acetylation at Lys80 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48871", "l": "H2O + NADH <=> AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0043548", "l": "phosphatidylinositol 3-kinase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938176", "l": "RUNX1:CBFB binds the PF4 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392834", "l": "Activation of EPACs by cAMP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11828", "l": "H2O + RNA(n)-2',3'-cyclic phosphate = H(+) + RNA(n)-2'- phosphate"}, {"i": "EC:3.1.4.58", "l": "\"RNA 2',3'-cyclic 3'-phosphodiesterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848829", "l": "CBL autoubiquitinates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629918", "l": "NEIL1 translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55421", "l": "hexadecanoyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16162", "l": "2 [Fe(III)-leghemoglobin] + NADH => 2 [Fe(II)-leghemoglobin] + H(+) + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50332", "l": "a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.6", "l": "\"Nucleoside-diphosphate kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809663", "l": "Formation of hair keratin fibres (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50218", "l": "(8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20821", "l": "choline sulfate + H2O => choline + H(+) + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51502", "l": "ADP + H(+) + N-acetyl-D-muramate 6-phosphate => ATP + N-acetyl-D-muramate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22787", "l": "(2R)-O-phospho-3-sulfolactate <=> H(+) + phosphoenolpyruvate + sulfite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22940", "l": "ATP + L-arginine = ADP + H(+) + N(omega)-phospho-L-arginine"}, {"i": "EC:2.7.3.3", "l": "\"Arginine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676598", "l": "TRAF2:cIAP1/2 complex binds FN14:TWEAK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975122", "l": "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16027", "l": "an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + CoA => an anthocyanidin 3-O-beta-D-glucoside + malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55893", "l": "a 2-all-trans-polyprenylphenol + H(+) + NADPH + O2 => a 3-(all-trans-polyprenyl)benzene-1,2-diol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53107", "l": "4-hydroxyestrone + S-adenosyl-L-methionine <=> 4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33041", "l": "2-oxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350578", "l": "NQO1 interaction with ODC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37586", "l": "D-lysine + H2O + O2 <=> 6-amino-2-oxohexanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429529", "l": "Thrombin binding to GP1b:IX:V (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433950", "l": "TRAF6 recruits TAK1 kinase complex  (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0004031", "l": "aldehyde oxidase activity"}, {"i": "REACT:R-HSA-3204311", "l": "AOX1 oxidises PXL to PDXate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31102", "l": "2-methylpropanoyl-CoA + FAD + H(+) <=> (2E)-2-methylpropenoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21502", "l": "H2O + UDP-4-dehydro-6-deoxy-alpha-D-glucose => UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371590", "l": "HSP70 binds to HSP40:nascent protein (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654623", "l": "Activated FGFR3 binds FRS3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428752", "l": "Dissociation of the TP:Gq complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17062", "l": "H(+) + NADPH + O2 + phenol => catechol + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61534", "l": "ent-kaur-16-en-19-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-ene + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60814", "l": "CO2 + gibberellin A12 + H(+) + succinate => 2-oxoglutarate + gibberellin A12 aldehyde + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43981", "l": "H(+) + hexadecanoate + NADPH + O2 => 15-hydroxyhexadecanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24491", "l": "H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33597", "l": "CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + tetracosanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20062", "l": "2'-deoxycytidine + a ribonucleoside 5'-triphosphate => a ribonucleoside 5'-diphosphate + dCMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027044", "l": "CYP4 ω-oxidises 14(R)-HDHA to MaR-L2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59711", "l": "D-maltotriono-1,5-lactone + H2O <=> D-maltotrionate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391168", "l": "SIRP gamma binds CD47 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "54.976352612608181", "identifiers": [{"i": "GO:0016746", "l": "acyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42547", "l": "uridine(32) in tRNA <=> pseudouridine(32) in tRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392195", "l": "Gi activation by P2Y purinoceptor 12 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64745", "l": "H2O + S-3-(hexan-1-ol)-L-cysteine => 3-sulfanyl-1-hexanol + NH4(+) + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24113", "l": "2 glutathione + O2 => glutathione disulfide + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51976", "l": "an L-N-hydroxypolyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = an L-N,N-dihydroxypolyhomomethionine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28835", "l": "citrate(out) + succinate(in) = citrate(in) + succinate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20883", "l": "10-hydroxydecanoate + NAD(+) <=> 10-oxodecanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49107", "l": "Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187382", "l": "Degradation of ubiquitinated SMAD3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033142", "l": "progesterone receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204485", "l": "Basigin binds CyPA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43934", "l": "androst-5-ene-3,17-dione + H(+) + NADH => 3beta-hydroxyandrost-5-en-17-one + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626228", "l": "The distal appendage proteins recruit TTBK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0097472", "l": "cyclin-dependent protein kinase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54898", "l": "(10Z,15Z)-12-oxophytodienoyl-CoA + AMP + diphosphate => (10Z,15Z)-12-oxophytodienoate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102065", "l": "patchoulene synthase activity"}, {"i": "MetaCyc:RXN-10602"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65472", "l": "2-methylbutanoyl-CoA + ethanol = CoA + ethyl 2-methylbutanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20643", "l": "3 H(+) + L-histidine + 2 NADH => H2O + L-histidinol + 2 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43010", "l": "2-aminoprop-2-enoate + H2O => D-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853762", "l": "RET dimerizes (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191654", "l": "c-src associates with Cx43 in gap junctions (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005328", "l": "neurotransmitter:sodium symporter activity"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0015368", "l": "calcium:cation antiporter activity"}, {"i": "REACT:R-HSA-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372425", "l": "fructose 2,6-bisphosphate + H2O => fructose 6-phosphate + orthophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020249", "l": "Hydroperoxy reductase reduces 4(S)-Hp-17(S)-HDHA to RvD6 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24020", "l": "2-(N(omega)-L-arginino)succinate = fumarate + L-arginine"}, {"i": "EC:4.3.2.1", "l": "\"Argininosuccinate lyase\""}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0032135", "l": "DNA insertion or deletion binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18988", "l": "chorismate <=> isochorismate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37660", "l": "anthraniloyl-CoA + methanol => CoA + O-methyl anthranilate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15610", "l": "ATP + D-ribose 5-phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38390", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 1,3-di-(9Z-octadecenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016167", "l": "glial cell-derived neurotrophic factor receptor activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047317", "l": "N6-acetyl-beta-lysine transaminase activity"}, {"i": "RHEA:16889", "l": "2-oxoglutarate + 6-acetamido-3-aminohexanoate = 6-acetamido-3-oxohexanoate + L-glutamate"}, {"i": "EC:2.6.1.65", "l": "\"N(6)-acetyl-beta-lysine transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37609", "l": "1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25797", "l": "2-oxoglutarate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22966", "l": "CO2 + putrescine => H(+) + L-ornithine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53826", "l": "7-oxotaurolithocholate + H(+) + NADH => NAD(+) + taurochenodeoxycholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787820", "l": "IL34 dimer binds CSF1R (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1462039", "l": "Pro-HNP1-4 are cleaved to biologically active defensin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50498", "l": "CoA + H(+) + N-terminal N(alpha)-acetylglycyl-[protein] => acetyl-CoA + N-terminal glycyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36715", "l": "sphinganine + tetracosenoyl-CoA = an N-tetracosenoylsphinganine + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6804741", "l": "MDM2 forms homo- or heterodimers (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50596", "l": "acetyl-CoA + N-terminal L-seryl-[histone H4] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H4]"}, {"i": "RHEA:50600", "l": "acetyl-CoA + N-terminal L-seryl-[histone H2A] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A]"}, {"i": "EC:2.3.1.257", "l": "\"N-terminal L-serine N(alpha)-acetyltransferase NatD\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32491", "l": "(1E,4E,8E)-alpha-humulene + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxy-alpha-humulene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}, {"i": "EC:1.14.14.113", "l": "\"Alpha-humulene 10-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602063", "l": "Defective CYP26B1 does not 4-hydroxylate atRA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38336", "l": "(20S)-ginsenoside Rb1 + 2 H2O => (20S)-ginsenoside Rg3 + 2 D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63627", "l": "hexadecanoyl-AMP + holo-[ACP] <=> AMP + H(+) + hexadecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62049", "l": "an N-aryl-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O => an N-aryl-1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27918", "l": "H2O + NADP(+) + propanal = 2 H(+) + NADPH + propanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218847", "l": "PAK2 binds NCK (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59964", "l": "L-seryl-[protein] + octanoyl-CoA = CoA + O-octanoyl-L-seryl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59490", "l": "ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate => ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40896", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O => (9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0019865", "l": "immunoglobulin binding"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102191", "l": "4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol dehydrogenase/C4-decarboxylase activity"}, {"i": "RHEA:59016", "l": "4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + NAD(+) = CO2 + cycloeucalenone + NADH"}, {"i": "EC:1.1.1.418", "l": "\"Plant 3-beta-hydroxysteroid-4-alpha-carboxylate 3-dehydrogenase (decarboxylating)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871265", "l": "YAP1 binds TEAD4 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173740", "l": "Factor B binds to C3(H2O) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877902", "l": "Activated AR binds RUNX2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418662", "l": "Src activation following P2Y purinoceptor activation (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66144", "l": "5-methoxytryptamine + acetyl-CoA = CoA + H(+) + melatonin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.3.-.-", "l": "\"Catalysing the translocation of inorganic anions and their chelates\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24796", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61229", "l": "H2O + L-histidine + O2 => 3-(imidazol-5-yl)pyruvate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21224", "l": "CDP-choline + sphing-4-enine = CMP + H(+) + sphing-4-enine-phosphocholine"}, {"i": "EC:2.7.8.10", "l": "\"Sphingosine cholinephosphotransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51510", "l": "CO2 + succinate + trans-4-hydroxy-L-proline => 2-oxoglutarate + L-proline + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59414", "l": "NH4(+) + oxaloacetate => 2-oxosuccinamate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2201338", "l": "TRAF3 binds TICAM1:activated TLR4 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008086", "l": "light-activated voltage-gated calcium channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27681", "l": "ATP + dCDP <=> ADP + dCTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23043", "l": "2-oxobutanoate + acetyl-CoA + H2O <=> (R)-2-ethylmalate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18304", "l": "ATP + NH4(+) + XMP <=> AMP + diphosphate + GMP + 2 H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10966", "l": "ADP + D-xylulose 5-phosphate + H(+) => ATP + D-xylulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28139", "l": "H2O + streptothricin F => streptothricin F acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653514", "l": "USP17L2 deubiquitinates RCE1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141439", "l": "Release of activated MAD2 from kinetochores (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64092", "l": "3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 = 3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50795", "l": "18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> aldosterone + 2 H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21013", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine => 4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42733", "l": "guanosine(527) in 16S rRNA + S-adenosyl-L-methionine => N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730837", "l": "Recruitment of GRB2:SOS to p-10Y-NTAL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209307", "l": "Phosphorylated STAT92E dimer activates transcription (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679045", "l": "C-ter TLR9 dimer binds HCQ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200646", "l": "Cytosolic folate export across the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61084", "l": "(2S)-naringenin + 2-oxoglutarate + O2 = (2R,3R)-dihydrokaempferol + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22898", "l": "a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+) => acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052821", "l": "DNA-7-methyladenine glycosylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52358", "l": "adenosine 3',5'-bisphosphate + H(+) + pregnenolone sulfate => 3'-phosphoadenylyl sulfate + pregnenolone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19109", "l": "1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose = 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose + H(+)"}, {"i": "EC:2.3.1.143", "l": "\"Beta-glucogallin--tetrakisgalloylglucose O-galloyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59577", "l": "anserine + H2O => beta-alanine + N(pros)-methyl-L-histidine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-372449", "l": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675947", "l": "TNFSF18 binds TNFRSF18 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112150", "l": "RNA Polymerase III Promoter Opening at Type 2 Promoters (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10349", "l": "5-oxo-L-proline + ATP + 2 H2O => ADP + H(+) + L-glutamate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50115", "l": "octadecanoyl-CoA + taurine <=> CoA + H(+) + N-octadecanoyl-taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008737", "l": "L-fuculokinase activity"}, {"i": "RHEA:12376", "l": "ATP + L-fuculose = ADP + H(+) + L-fuculose 1-phosphate"}, {"i": "EC:2.7.1.51", "l": "\"L-fuculokinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047245", "l": "N-acetylglucosaminyldiphosphoundecaprenol glucosyltransferase activity"}, {"i": "RHEA:20952", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose = beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}, {"i": "EC:2.4.1.188", "l": "\"N-acetylglucosaminyldiphosphoundecaprenol glucosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634834", "l": "ACHEIs bind ACHE (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693608", "l": "Initial resection of double-strand break ends (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964773", "l": "OXGR1 binds 2OG (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15187", "l": "CoA + H(+) + N(2)-succinyl-L-arginine => L-arginine + succinyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50720", "l": "FMNH2 + methanesulfinate + O2 = FMN + H(+) + H2O + methanesulfonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030251", "l": "guanylate cyclase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46456", "l": "5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH = 5alpha-cholest-8-en-3beta-ol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43104", "l": "AH2 + N-acyleicosasphinganine + O2 = A + 2 H2O + N-acyleicosasphing-4-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38110", "l": "2-dehydro-3-deoxy-L-galactonate <=> L-glyceraldehyde + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52344", "l": "(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803761", "l": "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10204", "l": "dimethylamine + H(+) + H2O + oxidized [electron-transfer flavoprotein] = formaldehyde + methylamine + reduced [electron-transfer flavoprotein]"}, {"i": "EC:1.5.8.1", "l": "\"Dimethylamine dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047249", "l": "sarsapogenin 3-beta-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14753", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = acetate + androst-4-ene-3,17-dione + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182990", "l": "Sprouty sequesters CBL away from active EGFR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28083", "l": "(2S)-ethylmalonyl-CoA + NADP(+) => (2E)-butenoyl-CoA + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102891", "l": "2'4'6'34-pentahydroxychalcone 4'-O-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52842", "l": "1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + UDP => 4-hydroxy-3-methoxybenzoate + UDP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046099", "l": "Desaturation of tetracosapentaenoyl-CoA to tetracosahexaenoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693599", "l": "Association of Ku heterodimer with ends of DNA double-strand break (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.12"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004479", "l": "methionyl-tRNA formyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062205", "l": "miltiradiene synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17508", "l": "H2O + N-(long-chain fatty acyl)ethanolamine <=> a long-chain fatty acid + ethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23132", "l": "3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite"}, {"i": "EC:1.8.7.1", "l": "\"Assimilatory sulfite reductase (ferredoxin)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662608", "l": "MT2A binds cadmium (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8871193", "l": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47650", "l": "phosphate + ribitol => D-ribitol 5-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12879", "l": "acetate + H(+) + methylglyoxal => acetylacetone + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390133", "l": "YKI transports from the cytosol to the nucleus (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71164", "l": "homogentisate + O2 => maleylacetoacetate (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38078", "l": "2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351341", "l": "Exocytosis of Proactivator polypeptide (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665748", "l": "FMNL2 binds RHOC:GTP (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2467811", "l": "Separation of sister chromatids (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22890", "l": "succinyl-CoA => (R)-methylmalonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3780997", "l": "PPP1R3C binds to glycogen:GYG2:GYS2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62994", "l": "NH4(+) + tetradecanoate => H2O + tetradecamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141437", "l": "Formation of the MCC complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56745", "l": "2-oxoglutarate + L-arginyl-[protein] + O2 => (3R)-3-hydroxy-L-arginyl-[protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31164", "l": "(3S)-hydroxyhexadecanoyl-CoA => (2E)-hexadecenoyl-CoA + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112436", "l": "Formation of Elongin complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39457", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+) => (2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30666", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole <=> hapalindole H"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008660", "l": "1-aminocyclopropane-1-carboxylate deaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62062", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+) => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551648", "l": "SUMOylation of TDG with SUMO1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28076", "l": "(R)-3-sulfolactate + 3 H(+) + 2 NADH => (2R)-3-sulfopropanediol + H2O + 2 NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56636", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46195", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta,7alpha-dihydroxyandrost-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41735", "l": "[(1->4)-alpha-D-glucosyl](n) + phosphate <=> [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20977", "l": "a primary nitroalkane + H2O + O2 => an aldehyde + H(+) + H2O2 + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16820", "l": "6-phospho-D-gluconate + NADP(+) <=> 6-phospho-2-dehydro-D-gluconate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20235", "l": "a 7-oxosteroid + H(+) + NADPH => a 7beta-hydroxysteroid + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43914", "l": "(25R)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54973", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-[ACP] => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29559", "l": "H2O + UDP-alpha-D-glucuronate = 1-phospho-alpha-D-glucuronate + 2 H(+) + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32726", "l": "L-trihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-6-(methylsulfanyl)hexanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2186771", "l": "RNF111 binds SMAD7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448632", "l": "IL34 dimerizes (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72672", "l": "The 60S subunit joins the translation initiation complex  (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50492", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9732692", "l": "Triazenes produce DNA damage in the form of O6-methylguanine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051908", "l": "double-stranded DNA 5'-3' exodeoxyribonuclease activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2430535", "l": "MASTL phosphorylates ENSA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034907", "l": "acetanilide 1,2-dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11657", "l": "ATP + holo-[peptidyl-carrier protein] + L-proline => AMP + diphosphate + L-prolyl-[peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49097", "l": "H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine => 3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35450", "l": "(1'S)-averantin + NADP(+) <=> H(+) + NADPH + norsolorinic acid"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17038", "l": "indole-3-ethanol + NADP(+) => H(+) + indole-3-acetaldehyde + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64270", "l": "emodin + H(+) + H2O => emodin anthrone + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20939", "l": "2,3-dihydroxy-3-methylbutanoate <=> 3-methyl-2-oxobutanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52152", "l": "(E)-2-(1H-indol-3-yl)-1-thioacetohydroximate + UDP-alpha-D-glucose = indolylmethyl-desulfoglucosinolate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350403", "l": "DGO binds to PK (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803391", "l": "TP53 binds the PCBP4 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64014", "l": "A + 3 CO2 + 4 CoA + fumigermin + H2O + 3 S-adenosyl-L-homocysteine => acetyl-CoA + AH2 + 3 malonyl-CoA + 3 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27706", "l": "ATP + D-alanine + D-serine = ADP + D-alanyl-D-serine + H(+) + phosphate"}, {"i": "EC:6.3.2.35", "l": "\"D-alanine--D-serine ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64701", "l": "1-phenylethanol + NAD(+) => acetophenone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60012", "l": "a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9615249", "l": "ARBs bind AGRT1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32023", "l": "(2E,6E)-farnesyl diphosphate + H2O = avermitilol + diphosphate"}, {"i": "EC:4.2.3.96", "l": "\"Avermitilol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61293", "l": "(R)-pantoate + NAD(+) => 2-dehydropantoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43578", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70982", "l": "Fumarate + H2O <=> (S)-Malate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39626", "l": "3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0051377", "l": "mannose-ethanolamine phosphotransferase activity"}, {"i": "REACT:R-HSA-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60092", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) = 4alpha-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34434", "l": "(+)-secoisolariciresinol + NADP(+) <=> (-)-lariciresinol + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36731", "l": "1-nitrocyclohexan + NADP(+) = 1-nitrocyclohexene + H(+) + NADPH"}, {"i": "EC:1.3.1.102", "l": "\"2-alkenal reductase (NADP(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008413", "l": "8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity"}, {"i": "RHEA:59980", "l": "8-oxo-dGTP + H2O = 8-oxo-dGDP + H(+) + phosphate"}, {"i": "RHEA:60032", "l": "8-oxo-GTP + H2O = 8-oxo-GDP + H(+) + phosphate"}, {"i": "EC:3.6.1.69", "l": "\"8-oxo-(d)GTP phosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62221", "l": "phyllostine => neopatulin"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0016624", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"}, {"i": "EC:1.2.4.-", "l": "\"With a disulfide as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55978", "l": "H(+) + S-sulfanylglutathione + sulfite => glutathione + thiosulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10847", "l": "oxaloacetate + pyridoxamine <=> L-aspartate + pyridoxal"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956676", "l": "YAP1 binds TP73 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357479", "l": "p-AXL binds PI3K (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047976", "l": "hamamelose kinase activity"}, {"i": "MetaCyc:HAMAMELOSE-KINASE-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28911", "l": "H(+)(out) + L-lysine(out) = H(+)(in) + L-lysine(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247843", "l": "secretion of WNT ligands (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32608", "l": "(6E)-8-hydroxygeraniol + NADP(+) => (6E)-8-hydroxygeranial + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174367", "l": "GCL ligates L-Glu to L-Cys (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047836", "l": "D-tryptophan N-malonyltransferase activity"}, {"i": "RHEA:23320", "l": "D-tryptophan + malonyl-CoA = CoA + H(+) + N(2)-malonyl-D-tryptophan"}, {"i": "EC:2.3.1.112", "l": "\"D-tryptophan N-malonyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202960", "l": "Caspase mediated cleavage of C-IAP1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22860", "l": "ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate"}, {"i": "EC:2.7.7.18", "l": "\"Nicotinate-nucleotide adenylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015650", "l": "lactate:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20421", "l": "alpha-maltose 6'-phosphate + H2O = D-glucose + D-glucose 6-phosphate"}, {"i": "EC:3.2.1.122", "l": "\"Maltose-6'-phosphate glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14675", "l": "a polar amino acid(in) + ADP + H(+) + phosphate => a polar amino acid(out) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693125", "l": "RHOF binds effectors at the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51598", "l": "4-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + p-xylene + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445448", "l": "HHIP binds Hedgehog (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354124", "l": "Phosphorylation of pPTK2 by SRC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14979", "l": "3-carboxy-cis,cis-muconate => 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12277", "l": "3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "ic": "83.899076217449789", "identifiers": [{"i": "GO:0008186", "l": "ATP-dependent activity, acting on RNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41033", "l": "1-O-hexadecyl-2-acetyl-3-decanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + decanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35017", "l": "riboflavin(out) => riboflavin(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399928", "l": "Recruitment of Rnd1 to Plexin A (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46691", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA + A <=> 3-oxo-cholest-4,24-dien-26-oyl-CoA + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32369", "l": "4 [Fe(II)cytochrome c] + 5 H(+) + L-dehydroascorbate => 4 [Fe(III)cytochrome c] + L-galactono-1,4-lactone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41902", "l": "3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + malonyl-[ACP] + tetradecanoyl-[ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019166", "l": "trans-2-enoyl-CoA reductase (NADPH) activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61560", "l": "gibberellin A15 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = gibberellin A24 + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061797", "l": "pH-gated chloride channel activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50899", "l": "8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O <=> (8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57394", "l": "3-O-acetyl-4'-O-demethylpapaveroxine + H(+) => (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59833", "l": "ATP + N(6)-(D-fructosyl)-L-lysyl-[protein] => ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23670", "l": "AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase] => apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682026", "l": "MRN bound to shortened telomeres activates ATM (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51059", "l": "A + androst-4-ene-3,17-dione <=> AH2 + androsta-1,4-diene-3,17-dione"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166223", "l": "The proton is delivered to the matrix side (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034569", "l": "monodemethylisoproturon dehydrogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1861788", "l": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211193", "l": "Homodimerization  of DFF40 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008043", "l": "MAPK8 phosphorylation (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33967", "l": "2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O = 3-maleylpyruvate + H(+)"}, {"i": "EC:3.1.1.91", "l": "\"2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800836", "l": "TP53 or TP63 binds the PERP gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55616", "l": "a carotenoid psi-end group = a carotenoid epsilon-end group"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705738", "l": "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786155", "l": "POLN binds ICL-DNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23840", "l": "3-(2,3-dihydroxyphenyl)propanoate + O2 = (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27922", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034870", "l": "pinacolone 5-monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.101", "l": "\"Mannan endo-1,6-alpha-mannosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701507", "l": "PTPN6 dephosphorylates JAK3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49350", "l": "2-oxospirilloxanthin + H2O => 2,2-dihydroxyspirilloxanthin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050084", "l": "mannitol-1-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36036", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+) => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22597", "l": "cephalosporin C + H2O => acetate + deacetylcephalosporin C + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952823", "l": "p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606682", "l": "MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35797", "l": "H(+) + kanamycin A + UDP => 2'-deamino-2'-hydroxyneamine + UDP-alpha-D-kanosamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21939", "l": "carbamoyl phosphate + putrescine <=> H(+) + N-carbamoylputrescine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937613", "l": "CRHBP binds CRH (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38874", "l": "uridine(2457) in 23S rRNA <=> pseudouridine(2457) in 23S rRNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37201", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948775", "l": "MKRN1 polyubiquitinates PTEN (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013159", "l": "CDC42 GEFs activate CDC42 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26383", "l": "H(+) + NADPH + succinate semialdehyde => 4-hydroxybutanoate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59182", "l": "2 AMP + H(+) => 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428909", "l": "Activated TP receptor binds G-protein  G13 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.61", "l": "\"Alpha-dystroglycan beta-1,4-xylosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865107", "l": "MICAL1 produces NADP+, H2O2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703440", "l": "FLT3 fusions:GRB2 bind GAB2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22043", "l": "H2O + N-formyl-L-aspartate <=> formate + L-aspartate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156682", "l": "PLK1 phosphorylates NUDC (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5689000", "l": "AADAC deacetylates PHEN (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666046", "l": "SRF:MKL1 binds ITGB1 Gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66251", "l": "CoA + IC-asc-C9-AMP <=> AMP + H(+) + IC-asc-C9-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31045", "l": "2 H(+) + methylmalonate + NADH => (S)-methylmalonate semialdehyde + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30608", "l": "A + all-trans-phytofluene => AH2 + all-trans-zeta-carotene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76500", "l": "TBXAS1 isomerises PGH2 to TXA2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44793", "l": "2-demethylmenaquinol-12 + S-adenosyl-L-methionine => H(+) + menaquinol-12 + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55429", "l": "ferruginol + O2 + reduced [NADPH--hemoprotein reductase] => 11-hydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18482", "l": "cyclohexylsulfamate + H2O => cyclohexylamine + sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000384", "l": "first spliceosomal transesterification activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39935", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66359", "l": "(5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + NAD(+) <=> (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209738", "l": "VD3 binds GC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1964496", "l": "STING binds TRIM32 or TRIM56  (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168280", "l": "Priming and Initiation of Transcription (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418904", "l": "A1 and A3 receptors bind adenosine (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31477", "l": "H(+) + soyasapogenol B 3-O-beta-D-glucuronate + UDP => soyasapogenol B + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46640", "l": "7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH = 7alpha-hydroxy-5beta-cholestan-3-one + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55289", "l": "tetradecan-1-ol + tetradecanoyl-CoA => CoA + tetradecanyl tetradecanoate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034792", "l": "hypophosphite dioxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27949", "l": "dopamine + H2O + O2 <=> 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043785", "l": "cinnamoyl-CoA:phenyllactate CoA-transferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64018", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-Glc + GDP + H(+) => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11388", "l": "an 11beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + H(+) + NADPH"}, {"i": "EC:1.1.1.146", "l": "\"11-beta-hydroxysteroid dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44906", "l": "alpha-D-glucose + phosphate => alpha-D-glucose 6-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-112385", "l": "Addition of nucleotides leads to transcript elongation (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64471", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NADP(+) <=> 4-methylsulfanyl-2-oxobutanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27622", "l": "geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate"}, {"i": "EC:2.5.1.89", "l": "\"Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55933", "l": "3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O => AMP + H(+) + L-threonyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28162", "l": "cytidine + GTP = CMP + GDP + H(+)"}, {"i": "EC:2.7.1.213", "l": "\"Cytidine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032582", "l": "Activated FYN binds GRIN2B (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433410", "l": "SOCS1 as a regulator of KIT signaling (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050362", "l": "L-tryptophan:2-oxoglutarate aminotransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31893", "l": "1-phenyl-1,2-propanedione + H(+) + NADPH => 2-hydroxy-1-phenyl-1-propanone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941312", "l": "ZCCHC6, ZCCHC11 are mRNA uridyltransferases (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198314", "l": "DAG stimulates protein kinase C-delta (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55012", "l": "(1S,4R)-1-hydroxylimonen-2-one + NADPH + O2 = (3R)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66125", "l": "2-oxobutanoate + L-histidine => (2S)-2-aminobutanoate + 3-(imidazol-5-yl)pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-419011", "l": "Transhomodimerization of Nectins (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8931981", "l": "RUNX1 binds ESR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20865", "l": "alpha,alpha-trehalose 6-phosphate + phosphate => beta-D-glucose 1-phosphate + D-glucose 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45707", "l": "(E)-sinapoyl alcohol + NADP(+) <=> (E)-sinapoaldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844612", "l": "PYCARD recruits procaspase-1 via CARD (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787820", "l": "IL34 dimer binds CSF1R (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49450", "l": "alpha-D-mannopyranose + beta-D-mannopyranosyl-(1->2)-D-mannopyranose => beta-D-Manp-(1->2)-beta-D-Manp-(1->2)-D-Manp + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66190", "l": "3',5'-cyclic GMP(out) + ADP + H(+) + phosphate => 3',5'-cyclic GMP(in) + ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41174", "l": "1-acyl-2-hexadecenoyl-sn-glycero-3-phosphate + H2O <=> 2-hexadecenoyl-sn-glycero-3-phosphate + a fatty acid + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382061", "l": "Extracellular processing of novel PDGFs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14819", "l": "4-fumarylacetoacetate => 4-maleylacetoacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-482772", "l": "Release of platelet cytosolic components (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "84.762172188404165", "identifiers": [{"i": "GO:0016886", "l": "ligase activity, forming phosphoric ester bonds"}, {"i": "EC:6.5.-.-", "l": "\"Forming phosphoric ester bonds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35100", "l": "fusidate(in) + H(+)(out) => fusidate(out) + H(+)(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47865", "l": "1,2,3-trioctanoylglycerol + H2O => dioctanoylglycerol + H(+) + octanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48755", "l": "2-oxoglutarate + O2 + validamycin A <=> CO2 + H(+) + succinate + validamycin B"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37471", "l": "3-methylbutanoyl-CoA + S-adenosyl-L-methionine = CoA + H(+) + N-isovaleryl-L-homoserine lactone + S-methyl-5'-thioadenosine"}, {"i": "EC:2.3.1.228", "l": "\"Isovaleryl-homoserine lactone synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63289", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 9-hydroperoxy-(5Z,7E,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670426", "l": "Disassociation and translocation of STATs to the nucleus downstream of KIT mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43508", "l": "2,5-diformylfuran + H2O = 2-(dihydroxymethyl)-5-formylfuran"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24606", "l": "H(+) + S-adenosyl-L-homocysteine + theobromine => 7-methylxanthine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42575", "l": "3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+) <=> 2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036077", "l": "Defective HYAL1 does not hydrolyse (HA)50 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-981497", "l": "ST3GAL1-4 can add a sialic acid to the T antigen at the alpha 3 position (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3341277", "l": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41592", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22012", "l": "precorrin-4 + S-adenosyl-L-methionine = precorrin-5 + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.133", "l": "\"Precorrin-4 C(11)-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047398", "l": "dolichylphosphate-mannose phosphodiesterase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033707", "l": "3''-deamino-3''-oxonicotianamine reductase activity"}, {"i": "MetaCyc:1.1.1.285-RXN"}, {"i": "EC:1.1.1.285", "l": "\"3''-deamino-3''-oxonicotianamine reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010503", "l": "HOXA2 binds ROBO2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40070", "l": "2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O <=> 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48035", "l": "(2S)-2-methylbutanoyl-CoA + FAD + H(+) <=> (2E)-2-methylbut-2-enoyl-CoA + FADH2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102637", "l": "5-aminolevulinate-CoA ligase activity"}, {"i": "MetaCyc:RXN-15714"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442749", "l": "CaMKK autophosphorylates in the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60065", "l": "a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2 => a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49337", "l": "2,2-dihydroxyspheroidene => H2O + spheroiden-2-one"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694563", "l": "ABHD10 hydrolyses MPAG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024726", "l": "LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59828", "l": "H2O + S-inosyl-L-homocysteine = inosine + L-homocysteine"}, {"i": "EC:3.13.1.9", "l": "\"S-inosyl-L-homocysteine hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22356", "l": "diphosphate + oxaloacetate = CO2 + phosphate + phosphoenolpyruvate"}, {"i": "EC:4.1.1.38", "l": "\"Phosphoenolpyruvate carboxykinase (diphosphate)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50303", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> all-trans-4-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58084", "l": "1-(13Z-docosenoyl)-glycerol + H2O = (13Z)-docosenoate + glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21367", "l": "H2O + N-(6-aminohexanoyl)-6-aminohexanoate <=> 2 6-aminohexanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669302", "l": "p-BMAL1:p-CLOCK,NPAS2 binds RORA gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64477", "l": "4-[(2E,7S,8E,10E,13R,14R,16E,18E)-14-ethyl-7,13-dihydroxy-2,16,18-trimethylicosa-2,8,10,16,18-pentaenoyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate => 4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66687", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[GAPDH] <=> L-cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71495", "l": "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102976", "l": "versiconal reductase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102416", "l": "quercetin gentiotrioside 1,6-glucosyltransferase activity"}, {"i": "MetaCyc:RXN-13799"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54826", "l": "alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) => H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39723", "l": "a 1,2-diacyl-sn-glycerol(in) = a 1,2-diacyl-sn-glycerol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619668", "l": "L-PRX:DRP:DGC:laminin-211 interacts with UTRN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43247", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210805", "l": "Removal of miRNA passenger strand (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68960", "l": "DNA polymerase epsilon binds at the origin (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15643", "l": "CO2 + pyruvate => H(+) + oxaloacetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9612501", "l": "SGK phosphorylates CREB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.129", "l": "\"Endo-alpha-sialidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63931", "l": "2 [Fe(II)-cytochrome b5] + an N-acylsphing-4-enine + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + an N-acyl-sphinga-4E,14Z-dienine + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004474", "l": "malate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694442", "l": "CNIH2,3 bind GRIA1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987214", "l": "p-STAT3 dimerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9032751", "l": "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46114", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2995334", "l": "COX15 transforms heme O to heme A (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9612509", "l": "SGK phosphorylates SRF (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24470", "l": "H2O + N,N-dimethylaniline N-oxide + NADP(+) => H(+) + N,N-dimethylaniline + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38976", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428273", "l": "SPHK1 phosphorylates SPG to S1P (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22428", "l": "N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = 2 H2O + isopenicillin N"}, {"i": "EC:1.21.3.1", "l": "\"Isopenicillin-N synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2984226", "l": "PLK1 phosphorylates NEK9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432590", "l": "Phosphorylated PER is phosphorylated by CK2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57405", "l": "NAD(+) + narcotine hemiacetal => H(+) + NADH + noscapine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58627", "l": "N-dodecanoyl-(2S)-hydroxyglycine <=> dodecanamide + glyoxylate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15243", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-yl acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13456", "l": "3'-phosphoadenylyl sulfate + quercetin <=> adenosine 3',5'-bisphosphate + H(+) + quercetin 3-sulfate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11012", "l": "H2O + L-tryptophanamide = L-tryptophan + NH4(+)"}, {"i": "EC:3.5.1.57", "l": "\"Tryptophanamidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13828", "l": "GDP-alpha-D-rhamnose + NAD(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14336", "l": "a 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol <=> 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391934", "l": "DP2 receptor can bind PGD2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.42", "l": "\"Cathepsin O\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671702", "l": "AP1G2 binds HGS and CHMP2A (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-453342", "l": "PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211391", "l": "Anthrax lef cleaves target cell MAP2K4 (MEK4) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63595", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086056", "l": "voltage-gated calcium channel activity involved in AV node cell action potential"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399930", "l": "Activation of PAK by Rac1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5252001", "l": "ATP1B4 binds SNW1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18966", "l": "hydroxymethylbilane => H2O + uroporphyrinogen III"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33604", "l": "H(+) + N-hexacosanoylsphinganine + NADPH + O2 => H2O + N-(2-hydroxyhexacosanoyl)-sphinganine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64108", "l": "H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9006873", "l": "IL21 receptor STAT binding (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56859", "l": "A + an aldehyde + H2O <=> a carboxylate + AH2 + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38886", "l": "a fatty acid + ATP + CoA <=> a fatty acyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047366", "l": "quercetin-3-sulfate 4'-sulfotransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047998", "l": "hyoscyamine (6S)-dioxygenase activity"}, {"i": "KEGG.REACTION:R03812"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163120", "l": "Disassociation of Telomerase RNP and the Chromosome End (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64414", "l": "H(+)(in) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) => H(+)(out) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62806", "l": "desertorin A + 2 H2O + NADP(+) => 2 7-demethylsiderin + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000327", "l": "PLK1 phosphorylates BORA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58397", "l": "4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + 5 H(+) + O2 + 4 reduced [2Fe-2S]-[ferredoxin] => 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NH4(+) + 4 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672083", "l": "KTN1 binds Kinesin-1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706298", "l": "Active FLT3 binds to CSK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989752", "l": "Expression of TXNRD1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013108", "l": "GDIs block activation of RHOC (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4085083", "l": "Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52431", "l": "12-oxo-leukotriene B4 + H(+) + NADH <=> 12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoate + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17101", "l": "H2O + O-acyl-(R)-carnitine = (R)-carnitine + a fatty acid + H(+)"}, {"i": "EC:3.1.1.28", "l": "\"Acylcarnitine hydrolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937369", "l": "ATAD2 binds ESR1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8873794", "l": "PCTP binds PC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27717", "l": "GMP + H2O <=> guanosine + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444171", "l": "Receptor FFAR2 binds carboxylates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-984606", "l": "Kinesin-5 is a homotetramer (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13513", "l": "(S)-dihydroorotate + NAD(+) = H(+) + NADH + orotate"}, {"i": "EC:1.3.1.14", "l": "\"Dihydroorotate dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34202", "l": "2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 <=> bracteatin 6-O-beta-glucoside + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11903", "l": "(1R,2S)-homoisocitrate + NAD(+) <=> 2-oxoadipate + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24073", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => 12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2197698", "l": "Src phosphorylate WASP,N-WASP (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029591", "l": "Expression of ABCG8 regulated by NR1H2 or NR1H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944223", "l": "Association of procollagen type V (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50813", "l": "androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36630", "l": "2-hydroxytetracosanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxytetracosanoyl)-sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451535", "l": "Dimerization of activated ERK2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975594", "l": "PLB1 hydrolyses RPALM to atROL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51945", "l": "8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine => 2 H(+) + roseoflavin + 2 S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22684", "l": "4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2 = (2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O"}, {"i": "EC:1.14.99.65", "l": "\"4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] 3-hydroxylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34830", "l": "H(+) + N-acyl-15-methylhexadecasphinganine + NADPH + O2 <=> H2O + N-acyl-4-hydroxy-15-methylhexadecasphinganine + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55185", "l": "2-oxoglutarate + 3-methylundecanoyl-CoA + O2 => 2-hydroxy-3-methylundecanoyl-CoA + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19244", "l": "ent-kaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-7alpha-hydroxykaur-16-en-19-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30467", "l": "(2Z,6Z)-farnesyl diphosphate = (+)-endo-beta-bergamotene + diphosphate"}, {"i": "EC:4.2.3.53", "l": "\"(+)-endo-beta-bergamotene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing)\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12476", "l": "H2O + N-formyl-L-glutamate = formate + L-glutamate"}, {"i": "EC:3.5.1.68", "l": "\"N-formylglutamate deformylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1006143", "l": "CD46 binds C3b (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2512800", "l": "SCARB1:ligand is endocytosed (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793066", "l": "TFB1M dimethylates adenosine-936 and adenosine-937 of 12S rRNA yielding 6-dimethyladenosine-936 and 6-dimethyladenosine-937 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25993", "l": "(2E,6E)-farnesyl diphosphate => (+)-epi-isozizaene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10040", "l": "adenosine 3',5'-bisphosphate + H2O = AMP + phosphate"}, {"i": "EC:3.1.3.7", "l": "\"3'(2'),5'-bisphosphate nucleotidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047320", "l": "D-4-hydroxyphenylglycine transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418172", "l": "F2R binds ARRB2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.73", "l": "\"Feruloyl esterase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871370", "l": "p-Y281,292-RUFY1 translocates from cytosol to early endosome membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30999", "l": "(S)-2,3-epoxysqualene = cucurbitadienol"}, {"i": "EC:5.4.99.33", "l": "\"Cucurbitadienol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675834", "l": "PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37652", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21855", "l": "(R)-10-hydroxyoctadecanoate <=> (9Z)-octadecenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902516", "l": "sn-glycerol 3-phosphate binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28574", "l": "H(+)(in) + sulfate(in) = H(+)(out) + sulfate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49043", "l": "(-)-5'-demethylyatein + S-adenosyl-L-methionine <=> (-)-yatein + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64376", "l": "8 A + a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid = a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 8 AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019981", "l": "interleukin-6 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62826", "l": "beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosamine + GDP + H(+) => beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + GDP-beta-L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52270", "l": "(1H-indol-3-yl)-N-methylmethanamine + H(+) + S-adenosyl-L-homocysteine => 3-(aminomethyl)indole + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19298", "l": "ATP + beta-alanine + L-histidine => ADP + carnosine + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033850", "l": "Z-farnesyl diphosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810376", "l": "ING2 binds PI5P (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265456", "l": "NPC1L1 binds ezetimibe (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39356", "l": "(2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H(+) + NADPH => (11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49322", "l": "(5R,6S)-5,6-epoxi-capsanthin => all-trans-violaxanthin"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953339", "l": "DNPH1 hydrolyses dGMP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64897", "l": "2 H2O + UTP => 2 H(+) + 2 phosphate + UMP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50062", "l": "ADP + glycochenodeoxycholate(out) + H(+) + phosphate => ATP + glycochenodeoxycholate(in) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949580", "l": "F1Fo ATP synthase dimerizes (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37186", "l": "(9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate <=> 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "75.582117822819498", "identifiers": [{"i": "GO:0070566", "l": "adenylyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75891", "l": "Abortive Initiation After Second Transition (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35503", "l": "11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 30-hydroxy-11-oxo-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72663", "l": "De novo formation of eIF2:GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1297333", "l": "Association of Acrosin Heavy and Light Chain (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64975", "l": "dUDP + H2O <=> dUMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951951", "l": "RUNX3 binds EP300 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877902", "l": "Activated AR binds RUNX2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37132", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170796", "l": "NPC transports GCK1:GKRP from cytosol to nucleoplasm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38970", "l": "an N-acylsphing-4-enine(in) + ATP + H2O <=> ADP + an N-acylsphing-4-enine(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33607", "l": "(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140761", "l": "sequestered tissue factor -> tissue factor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15305", "l": "betaine aldehyde + H2O + NAD(+) = glycine betaine + 2 H(+) + NADH"}, {"i": "EC:1.2.1.8", "l": "\"Betaine-aldehyde dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008756", "l": "o-succinylbenzoate-CoA ligase activity"}, {"i": "RHEA:17009", "l": "2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate"}, {"i": "EC:6.2.1.26", "l": "\"o-succinylbenzoate--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005121", "l": "Toll binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008822", "l": "PPM1D dephosphorylates RUNX2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38812", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5620975", "l": "MLKL binds PIPs (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54170", "l": "a 5'-(N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-(N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483219", "l": "PC is exchanged with PI by PITPNB (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9648017", "l": "EML4 binds to microtubules (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3828025", "l": "DCN (decorin) degradation by MMP14 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139905", "l": "Translocation of activated BAD protein to mitochondria (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669158", "l": "NF2 binds PAK1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44694", "l": "CoA + H(+) + N-acylhexadecasphinganine => a fatty acyl-CoA + hexadecasphinganine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102033", "l": "long-chain fatty acid omega-hydroxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51053", "l": "5alpha-androstan-3,17-dione + A => 5alpha-androst-1-ene-3,17-dione + AH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64881", "l": "CDP + H2O => CMP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32661", "l": "(6E)-8-oxogeranial + 2 H(+) + 2 NADPH => (6E)-8-hydroxygeraniol + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20791", "l": "NAD(+) + phosphate <=> ADP-D-ribose 1''-phosphate + H(+) + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55221", "l": "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74715", "l": "Autophosphorylation of insulin receptor (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18207", "l": "11alpha-hydroxyprogesterone + A + H2O => AH2 + O2 + progesterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18209", "l": "(2E)-geranyl diphosphate = (2S,4R)-bornyl diphosphate"}, {"i": "EC:5.5.1.8", "l": "\"(+)-bornyl diphosphate synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21281", "l": "H2O + 2 O2 + thiamine => H(+) + 2 H2O2 + thiamine acetate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60852", "l": "a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102550", "l": "2-methyl-6-geranylgeranyl-1,4-benzoquinol methyltransferase activity"}, {"i": "MetaCyc:RXN-14917"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2993802", "l": "HLCS biotinylates PC:Mn2+ (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446077", "l": "BP230 interacts with keretin K5/K14 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14422", "l": "H2O + N(2)-benzoyl-D-arginine-4-nitroanilide => 4-nitroaniline + H(+) + N(2)-benzoyl-D-arginine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169406", "l": "ISGylation of host proteins (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162590", "l": "Import of PIC to the Host Nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5368582", "l": "CXXC4 binds DVL to prevent AXIN binding (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130349", "l": "Generation of CLIP from lip10 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141671", "l": "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56189", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60280", "l": "L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.367", "l": "\"[Histone H3]-lysine(9) N-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60810", "l": "CO2 + gibberellin A20 + H2O => gibberellin A19 + H(+) + O2"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004346", "l": "glucose-6-phosphatase activity"}, {"i": "REACT:R-HSA-3262512", "l": "G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2090079", "l": "GLB1 hydrolyses linker chain(2) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.94", "l": "\"Glucan 1,6-alpha-isomaltosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60058", "l": "a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + 2 H2O + NAD(+) => a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195739", "l": "Palmitoylation of cysteine residues on M2 in the cis-golgi network (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390078", "l": "14-3-3 dimer binds to phosphorylated YKI (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.116", "l": "\"3-hydroxypropionyl-CoA dehydratase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928646", "l": "EPHAs bind EFNAs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31334", "l": "ATP + H(+) + molybdopterin <=> adenylyl-molybdopterin + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034853", "l": "2,4,4-trimethyl-3-oxopentanoate decarboxylase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450187", "l": "TAK1 is activated within the TAK1 complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429714", "l": "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134953", "l": "DHX36 or DHX9 binds MyD88 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63617", "l": "prunetin + UDP-alpha-D-glucuronate => H(+) + prunetin-C(8)-beta-D-glucuronide + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-435244", "l": "PECAM1 is phosphorylated (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445072", "l": "Interaction of PAK1 with Rac1-GTP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1671687", "l": "PRLR activation (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66014", "l": "[collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O => (5R)-5-hydroxy-L-lysyl-[collagen] + hypobromite + L-methionyl-[collagen]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418200", "l": "SRC-1 bound to ARRB2 is not activated (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102618", "l": "oryzalexin B synthase activity"}, {"i": "MetaCyc:RXN-15466"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53407", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> 13-hydroxy-(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61906", "l": "H2O + NADP(+) + stemphyloxin II => betaenone A + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63462", "l": "(2E,6E,10E)-geranylgeranyl phosphate + GDP + H(+) => (2E,6E,10E)-geranylgeraniol + GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112155", "l": "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666178", "l": "RTKN binds RHOA, RHOC or RHOB (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18557", "l": "1-O-alkyl-sn-glycero-3-phosphate + acetyl-CoA = 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA"}, {"i": "EC:2.3.1.105", "l": "\"Alkylglycerophosphate 2-O-acetyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814831", "l": "TBC1D20 binds RAB1:GTP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804100", "l": "HMGB1 binds LPS (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433374", "l": "Processing of SCF isoform 1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39645", "l": "(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+) => (2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27974", "l": "6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-deazaguanine + NH4(+)"}, {"i": "EC:4.3.99.3", "l": "\"7-carboxy-7-deazaguanine synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050058", "l": "linoleate isomerase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632182", "l": "PRMT1 methylates ESRs (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40738", "l": "(20S)-ginsenoside Rb1 + 2 H2O <=> 2 D-glucose + gypenoside LXXV"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060698", "l": "endoribonuclease inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432559", "l": "PER is phosphorylated by DCO (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55368", "l": "(R)-carnitine + H(+) + NADPH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28462", "l": "pyridoxal(in) = pyridoxal(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036468", "l": "L-dopa decarboxylase activity"}, {"i": "RHEA:12272", "l": "H(+) + L-dopa = CO2 + dopamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203070", "l": "Association of profilin with monomeric actin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43599", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 <=> 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187506", "l": "Translocation of p27 to the nucleoplasm (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18674", "l": "ATP + L-seryl-[receptor-protein] => ADP + H(+) + O-phospho-L-seryl-[receptor-protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28949", "l": "H(+)(in) + L-arabinose(out) => H(+)(out) + L-arabinose(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853898", "l": "VENTX binds the CSF1R (M-CSF-R) gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0016826", "l": "hydrolase activity, acting on acid sulfur-nitrogen bonds"}, {"i": "EC:3.10.-.-", "l": "\"Acting on sulfur-nitrogen bonds\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418874", "l": "Recruitment and activation of N-WASP by Cdc42 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3318415", "l": "ATF2 acetylates histone H2B, H4 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5629203", "l": "HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 4xMeR-PIWIL1:piRNA:TDRD6:TDRKH (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62763", "l": "4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23392", "l": "(nucleoside 5'-monophosphate)n + (n-1) H2O = n a ribonucleoside 5'-phosphate + n H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389969", "l": "Beta-tubulin:GTP + Cofactor D ->  Beta-tubulin:GTP: Cofactor D (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63058", "l": "5-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine => acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14737", "l": "CTP = 3',5'-cyclic CMP + diphosphate"}, {"i": "EC:4.6.1.6", "l": "\"Cytidylate cyclase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466828", "l": "Defective RBP4 does not bind atROL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418091", "l": "F2R binds ARRB1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112395", "l": "Abortive termination of elongation after arrest (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55988", "l": "H2O + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] = beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]"}, {"i": "EC:3.2.1.106", "l": "\"Mannosyl-oligosaccharide glucosidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65896", "l": "glyoxylate + L-kynurenine = glycine + H2O + kynurenate"}, {"i": "RHEA:65900", "l": "3-hydroxy-L-kynurenine + glyoxylate = glycine + H2O + xanthurenate"}, {"i": "EC:2.6.1.63", "l": "\"Kynurenine--glyoxylate transaminase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.-", "l": "\"Endoribonucleases producing 5'-phosphomonoesters\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417829", "l": "P2RY12 binds ADP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25509", "l": "(2E)-geranyl diphosphate => (1S,5S)-sabinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373716", "l": "DCC interacting NCK-1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44002", "l": "2-hydroxy-3-methylhexadecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methylhexadecanoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38294", "l": "(S)-malyl-CoA + H2O <=> (S)-malate + CoA + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030429", "l": "kynureninase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.147", "l": "\"ADP-specific glucose/glucosamine kinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27946", "l": "dopamine + H2O + O2 = 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112727", "l": "Serine phosphorylation of STATs (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57659", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1b <=> CMP + ganglioside GT1balpha + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227695", "l": "NLRC5 binds to CARD domain of Mda5 and prevents IPS1 binding. (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25480", "l": "acetoacetate + succinyl-CoA = acetoacetyl-CoA + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10812", "l": "H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + N-succinyl-L-glutamate + NADH"}, {"i": "EC:1.2.1.71", "l": "\"Succinylglutamate-semialdehyde dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41097", "l": "H(+) + phosphocholine + sphing-4-enine => H2O + sphing-4-enine-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11885", "l": "3'-phosphoadenylyl sulfate + cortisol => adenosine 3',5'-bisphosphate + cortisol 21-sulfate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24169", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16167", "l": "CO2 + H2O + indole-3-acetamide => L-tryptophan + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64143", "l": "an N-(fatty acyl)-L-asparagine + H2O <=> a fatty acid + L-asparagine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909720", "l": "IFN alpha/beta binds to IFNAR2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63297", "l": "an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3-carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'-thioadenosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53286", "l": "3-dehydro-scyllo-inosose + H(+) + NADH => NAD(+) + scyllo-inosose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008191", "l": "metalloendopeptidase inhibitor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876446", "l": "p-ULK1 phosphorylates DENND3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.81", "l": "\"ADAM10 endopeptidase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421835", "l": "trans-Golgi Network Vesicle Scission (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48351", "l": "a uridine in RNA <=> a pseudouridine in RNA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15888", "l": "NADP(+) + propane-1,2-diol <=> (S)-lactaldehyde + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050171", "l": "phenol beta-glucosyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788999", "l": "HV1-mediated H+ transfer (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43673", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.52", "l": "\"Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051265", "l": "diolein transacylation activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42111", "l": "(20S)-hydroxypregn-4-en-3-one + NAD(+) <=> H(+) + NADH + progesterone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097434", "l": "succinate:proton symporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20108", "l": "ADP + beta-D-fructose 6-phosphate <=> AMP + beta-D-fructose 1,6-bisphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696997", "l": "USP24 deubiquitinates DDB2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36882", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + AH2 + O2 <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + A + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25896", "l": "H(+) + malonate = acetate + CO2"}, {"i": "EC:4.1.1.88", "l": "\"Biotin-independent malonate decarboxylase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030911", "l": "TPR domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38429", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) + hexadecanoate => 1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50848", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25563", "l": "9alpha-copalyl diphosphate <=> 9beta-pimara-7,15-diene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9659820", "l": "RB1 translocates to the nucleus (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015615", "l": "D-allose-importing ATPase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54478", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + dodecanoate + H(+) => 1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25140", "l": "(2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) => 3-amino-2-oxopropyl phosphate + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20610", "l": "2-dehydro-3-deoxy-D-arabinonate => glycolaldehyde + pyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2032775", "l": "YAP1 binds TEAD1 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74742", "l": "Phosphorylation of SHC1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784648", "l": "CREB3L3 (1-?) translocates from cytosol to nucleoplasm (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56280", "l": "3'-L-prolyl-AMP + holo-[peptidyl-carrier protein] = AMP + L-prolyl-[peptidyl-carrier protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32349", "l": "3',5'-di-O-methyltricetin + 2 H(+) + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + tricetin"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102542", "l": "aclacinomycin A methylesterase activity"}, {"i": "MetaCyc:RXN-14863"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033798", "l": "thyroxine 5-deiodinase activity"}, {"i": "MetaCyc:1.97.1.11-RXN"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19654", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NAD(+) => CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389348", "l": "Activation of Rac1 by pVav1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58531", "l": "15alpha-stemmadenine intermediate I + H2O + NADPH <=> (16R)-deshydroxymethyl-stemmadenine + formate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63104", "l": "H(+) + ilicicolin A epoxide + NADPH + O2 = 16-hydroxy-ilicicolin A epoxide + H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106156", "l": "peptidyl-lysine 4-dioxygenase activity"}, {"i": "RHEA:57156", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 = 4-hydroxy-L-lysyl-[protein] + CO2 + succinate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75172", "l": "Formation of RAD50:MRE11 complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806613", "l": "Keratin tetramers bind to form unit length filaments (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11066", "l": "beta-D-fructose 6-phosphate + phosphate => beta-D-fructose 1,6-bisphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-912727", "l": "CBL binds VAV (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956676", "l": "YAP1 binds TP73 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57777", "l": "2-chloro-6-nitrotoluene + NADH + O2 => 4-chloro-3-methylcatechol + NAD(+) + nitrite"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.63", "l": "\"Oryzin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428127", "l": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6791235", "l": "GADD45A binds AURKA (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21628", "l": "17alpha-hydroxyprogesterone + NADPH + O2 = acetate + androst-4-ene-3,17-dione + H2O + NADP(+)"}, {"i": "EC:1.14.13.54", "l": "\"Ketosteroid monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28373", "l": "oxaloacetate + phosphate <=> hydrogencarbonate + phosphoenolpyruvate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43613", "l": "S-adenosyl-L-methionine + uridine(341) in tmRNA => 5-methyluridine(341) in tmRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43264", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA = 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033851", "l": "lavandulyl diphosphate synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8866851", "l": "CFTR transits to the plasma membrane (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36315", "l": "2 H(+) + hexadecanoyl-CoA + 2 NADPH = CoA + hexadecan-1-ol + 2 NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25159", "l": "(R)-4'-phosphopantothenate + ATP + L-cysteine <=> AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10088", "l": "sucrose + UDP-alpha-D-galactose = 6(F)-alpha-D-galactosylsucrose + H(+) + UDP"}, {"i": "EC:2.4.1.167", "l": "\"Sucrose 6(F)-alpha-galactosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694441", "l": "CSNK1D phosphorylates SEC23 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018826", "l": "methionine gamma-lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5685230", "l": "CHEK1 phosphorylates RAD51 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12361", "l": "(2E)-2-methylbut-2-enoyl-CoA + 13-hydroxylupanine => 13-(2-methylcrotonoyloxy)lupanine + CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062045", "l": "L-lysine alpha-aminotransferase"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416929", "l": "PTGFR binds PGF2a (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48163", "l": "3 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] <=> epoxypheophorbide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9706399", "l": "RHOBTB3 hydrolyzes ATP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16536", "l": "L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2855047", "l": "Hydrolysis of internal thioester in C4b (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69152", "l": "Removal of remaining Flap (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168849", "l": "tBID binds to inactive BAX protein (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810030", "l": "MTMR2 binds MTMR10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22173", "l": "beta-D-fructose 6-phosphate + UDP-alpha-D-glucose => H(+) + sucrose 6(F)-phosphate + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429730", "l": "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114419", "l": "Dissociation of Caspase-3 from DIABLO:XIAP:Caspase-3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25830", "l": "A + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O => AH2 + an N-acyl-(4R)-4-hydroxysphinganine + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940001", "l": "RUNX2:CBFB binds the MMP13 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419462", "l": "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.n2", "l": "\"Fatty acyl-CoA reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17503", "l": "16-epivellosimine + CO2 + methanol => H2O + polyneuridine aldehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43456", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28712", "l": "H(+)(in) + N-(4-aminobenzoyl)-L-glutamate(in) => H(+)(out) + N-(4-aminobenzoyl)-L-glutamate(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54903", "l": "(2E)-hexadecenoyl-[ACP] + H(+) + NADH <=> hexadecanoyl-[ACP] + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58169", "l": "(2E,6E)-farnesyl diphosphate => (-)-5-epi-eremophilene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0070064", "l": "proline-rich region binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15995", "l": "2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NADP(+) => anthraniloyl-CoA + 2 H(+) + 2 NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61975", "l": "1-O-(13-methyltetradecyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 1-O-(1Z-13-methyltetradecenyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731141", "l": "Syndecan-1 binds fibronectin (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050781", "l": "ortho-trichlorophenol reductive dehalogenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62632", "l": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O"}, {"i": "EC:1.11.1.27", "l": "\"Glutathione-dependent peroxiredoxin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44942", "l": "1-O-alkyl-3-acyl-sn-glycerol + a fatty acid + H(+) => 1-O-alkyl-2,3-diacyl-sn-glycerol + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61887", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-9-hydroperoxy-20-hydroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69005", "l": "Cdc6 protein is phosphorylated by CDK (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30006", "l": "alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose <=> alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042469", "l": "versicolorin reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102173", "l": "24-methylenecycloartanol 4alpha-methyl oxidase activity"}, {"i": "RHEA:58836", "l": "24-methylenecycloartanol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}, {"i": "MetaCyc:RXN-11926"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10609", "l": "(E)-cinnamate + O2 + reduced [NADPH--hemoprotein reductase] => (E)-4-coumarate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38675", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}]}
{"type": "biolink:MolecularActivity", "ic": "83.127010562534593", "identifiers": [{"i": "GO:0008527", "l": "taste receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165195", "l": "GTP loading by Rheb (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9688838", "l": "RIPK3 binds STUB1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381109", "l": "IRE1 binds IRE1 forming dimer (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64184", "l": "H2O + N-(9Z-octadecenoyl)-L-tyrosine = (9Z)-octadecenoate + L-tyrosine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799416", "l": "TP53 stimulates expression of TP53INP1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44645", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O => a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11431", "l": "beta-D-glucose + O2 <=> D-glucono-1,5-lactone + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11228", "l": "(2S)-flavan-4-ol + NADP(+) = (2S)-flavanone + H(+) + NADPH"}, {"i": "EC:1.1.1.234", "l": "\"Flavanone 4-reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416929", "l": "PTGFR binds PGF2a (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018780", "l": "dichloroacetate halidohydrolase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209738", "l": "VD3 binds GC (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000250", "l": "lanosterol synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675417", "l": "PEBP1 binds activated RAF1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17398", "l": "a (3R)-hydroxyacyl-[ACP] + NADP(+) => a 3-oxoacyl-[ACP] + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22548", "l": "H2O + L-lysine + O2 = (S)-2-amino-6-oxohexanoate + H2O2 + NH4(+)"}, {"i": "EC:1.4.3.20", "l": "\"L-lysine 6-oxidase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102725", "l": "24-methyldesmosterol reductase activity"}, {"i": "MetaCyc:RXN-708"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45946", "l": "4-hydroxy-6-(13-methyl-2-oxotetradecyl)pyran-2-one + 3 CO2 + 4 CoA => 12-methyltridecanoyl-CoA + 3 H(+) + 3 malonyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18869", "l": "ATP + L-xylulose = ADP + H(+) + L-xylulose 5-phosphate"}, {"i": "EC:2.7.1.53", "l": "\"L-xylulokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43468", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 = (8Z,10E,14Z)-12-hydroperoxyeicosatrienoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49311", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O <=> a neolactoside nLc4Cer(d18:0) + L-fucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42904", "l": "guanosine(748) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(748) in 23S rRNA + S-adenosyl-L-homocysteine"}, {"i": "EC:2.1.1.188", "l": "\"23S rRNA (guanine(748)-N(1))-methyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56487", "l": "3 O2 + oleanolate + 3 reduced [NADPH--hemoprotein reductase] <=> gypsogenate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33778", "l": "a 1,2-diacyl-sn-glycerol + CDP-N,N-dimethylethanolamine <=> 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40031", "l": "ent-copalyl diphosphate + H2O = diphosphate + ent-manool"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11744", "l": "H2O + thiamine triphosphate = H(+) + phosphate + thiamine diphosphate"}, {"i": "EC:3.6.1.28", "l": "\"Thiamine-triphosphatase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938773", "l": "RNF144A polyubiquitinates PRKDC (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35461", "l": "cholest-5-en-3-one + H(+) + NADH => cholesterol + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674430", "l": "PDGFR mutants bind type II TKIs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198270", "l": "PDPK1 phosphorylates AKT at T308 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112430", "l": "Formation of P-TEFb complex (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954056", "l": "E2F6 binds TFDP2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66397", "l": "ATP + cholate(in) + glutathione(in) + H2O => ADP + cholate(out) + glutathione(out) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008432", "l": "JUN kinase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53567", "l": "9,10-epoxy-(12Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-9,10-epoxy-(12Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1564120", "l": "Collagen type VII degradation by MMP1,2,3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33381", "l": "(4R)-hydroxyeicosasphinganine + phosphate => 4-hydroxyeicosasphinganine 1-phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390835", "l": "DRD1,5 bind DA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66211", "l": "(8R)-8-hydroxynonanoyl-CoA + O2 <=> (2E,8R)-8-hydroxynonenoyl-CoA + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44569", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + H(+) => 2-all-trans-hexaprenylphenol + CO2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034841", "l": "mentha-1,3-dione-CoA ligase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65963", "l": "ATP + H2O + leukotriene C4(out) <=> ADP + H(+) + leukotriene C4(in) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610735", "l": "NUMB binds ITCH (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032426", "l": "NTRK2 phosphorylates FRS3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63983", "l": "4-thiouridine + ATP <=> 4-thiouridine 5'-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0051032", "l": "nucleic acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404200", "l": "IGF1,2 binds IGF1R (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53013", "l": "2,5-dichlorohydroquinone + 2 glutathione => chloride + chlorohydroquinone + glutathione disulfide + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53738", "l": "a halide anion + catechol + CO2 + NAD(+) => a 2-halobenzoate + H(+) + NADH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66791", "l": "N-methyl-L-dopa + O2 <=> (3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52397", "l": "4-O-phospho-D-threonate + NAD(+) => CO2 + dihydroxyacetone phosphate + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26502", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP-alpha-D-glucose = 2 H(+) + ternatin C5 + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222491", "l": "Lactoferrin scavenges iron ions (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14970", "l": "S-adenosyl-L-methionine + trans-aconitate => (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389862", "l": "Conversion of glyoxylate to oxalate (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296045", "l": "Activation of Potassium transport channels (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9699007", "l": "FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61241", "l": "H2O + L-phenylalanine + O2 => 3-phenylpyruvate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390597", "l": "Release Of ADP From Myosin (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25848", "l": "(1S,5S)-carveol + NAD(+) = (S)-carvone + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14332", "l": "2-oxoglutarate + O-phospho-L-serine <=> 3-phosphooxypyruvate + L-glutamate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29168", "l": "H2O + pyruvate + ubiquinone-8 => acetate + CO2 + ubiquinol-8"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655142", "l": "RCHY1 binds POLH (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14438", "l": "H2O + L-lysine + O2 => 6-amino-2-oxohexanoate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5333678", "l": "CPNEs bind PL (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392195", "l": "Gi activation by P2Y purinoceptor 12 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65258", "l": "A + H2O + verruculide C epoxide => AH2 + O2 + verruculide C"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626220", "l": "C2CD3 binds the mother centriole (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54077", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + stellata-2,6,19-triene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694527", "l": "Loss of SAR1B GTPase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044823", "l": "retroviral integrase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980122", "l": "DTX binds NOTCH1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371567", "l": "DBC1 is phosphorylated by ATM/ART (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507873", "l": "Aquaporins passively transport urea out of cells (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35572", "l": "(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] => (1'S,5'S)-5'-hydroxyaverantin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39389", "l": "(2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685605", "l": "SLAMF7 binds SLAMF7 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64790", "l": "(E)-cinnamoyl-CoA + AMP + diphosphate => (E)-cinnamate + ATP + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692764", "l": "MAPK6 binds CCND3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24376", "l": "apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin = AMP + diphosphate + H(+) + holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]"}, {"i": "EC:6.3.4.11", "l": "\"Biotin--[methylcrotonoyl-CoA-carboxylase] ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189069", "l": "sucrose + H2O => glucose + fructose (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42832", "l": "(2E)-octenal + H(+) + pyruvate = (S)-3-acetyloctanal + CO2"}, {"i": "EC:2.2.1.12", "l": "\"3-acetyloctanal synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199131", "l": "PVR binds CD226 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989768", "l": "Expression of TIAM2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433454", "l": "Phosphorylation of GAB2 by SFKs (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16624", "l": "dihydrosanguinarine + H(+) + O2 <=> H2O2 + sanguinarine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31950", "l": "ent-isokaurene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-isokauren-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168947", "l": "Ligand binds to TLR10 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67119", "l": "N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59375", "l": "1-hexadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + 10-hydroxyoctadecanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592362", "l": "Activation of proMMP7 by MMP3 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218820", "l": "Src kinases phosphorylate VAV (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74712", "l": "Dissociation of IRS-P from insulin receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864395", "l": "TFAP2A,TFAP2C homodimers stimulate ESR1 gene expression (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432909", "l": "Interaction of Plectin with Integrin beta 4 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19257", "l": "a secondary alcohol + NADP(+) = a ketone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46528", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047332", "l": "diphosphate-serine phosphotransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015567", "l": "alkane transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167196", "l": "Recruitment of elongation factors to form HIV-1 elongation complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614544", "l": "Sulfite is oxidized to sulfate (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30343", "l": "FAD + H(+) + succinate = FADH2 + fumarate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28060", "l": "L-xylulose => L-lyxose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684275", "l": "IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685606", "l": "CLEC2D binds KLRB1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24354", "l": "ethyl 3-oxohexanoate + H(+) + NADPH => ethyl (R)-3-hydroxyhexanoate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47053", "l": "(2E,6E)-farnesyl diphosphate => alpha-selinene + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63187", "l": "NADH + 2 O2 <=> H(+) + NAD(+) + 2 superoxide"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62685", "l": "norrubrofusarin + S-adenosyl-L-methionine => H(+) + rubrofusarin + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080030", "l": "methyl indole-3-acetate esterase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46028", "l": "H2O2 + tetradecanoate = (2R)-hydroxytetradecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46561", "l": "2 [Fe(II)-cytochrome b5] + episterol + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + ergosta-5,7,24(28)-trien-3beta-ol + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18191", "l": "[(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+) => [(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48661", "l": "8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375135", "l": "Basigin binds Matrix metalloproteinase-1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43629", "l": "L-serine + NAD(+) => aminoacetaldehyde + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15229", "l": "alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-alpha-D-mannose"}, {"i": "EC:2.7.7.13", "l": "\"Mannose-1-phosphate guanylyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5252072", "l": "AZGP1 binds PIP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196017", "l": "Dynamin is recruited to the gap junction plaque (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29388", "l": "CTP + H2O => CDP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31077", "l": "(2E)-dodecenoyl-CoA + H2O => (3S)-3-hydroxydodecanoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41030", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + tetradecanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-tetradecanoyl-sn-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202111", "l": "AKT1 phosphorylates eNOS (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626067", "l": "EEF1A1:GTP translocates from lysosomal membrane to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-164834", "l": "Enzyme-bound ATP is released (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071796", "l": "K6-linked polyubiquitin modification-dependent protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24588", "l": "ATP + D-arabinose = ADP + D-arabinose 5-phosphate + H(+)"}, {"i": "EC:2.7.1.54", "l": "\"D-arabinokinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032190", "l": "acrosin binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39410", "l": "3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35956", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin B => 6-hydroxytryprostatin B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784734", "l": "PCSK9 binds LDLR (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72160", "l": "Cleavage at the 3'-Splice Site and Exon Ligation (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203130", "l": "OLR1 binds to oxidized LDL (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30559", "l": "GTP + H2O = guanosine + H(+) + triphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31314", "l": "(2R)-3-phosphoglycerate + ADP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14272", "l": "2 a quinone + H(+) + NADPH <=> 2 a 1,4-benzosemiquinone + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "91.94953810872488", "identifiers": [{"i": "GO:0016168", "l": "chlorophyll binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.n1"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802999", "l": "DCD is processed into DCD(63-110) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983266", "l": "Kinesins bind microtubules (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656891", "l": "OPN1SW binds 11cRAL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10053", "l": "(R)-2-hydroxy-4-methylpentanoate + NAD(+) => 4-methyl-2-oxopentanoate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264622", "l": "Cho is acetylated to AcCho by CHAT (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608866", "l": "VANGL2 is required for asymmetric membrane localization of FZD3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654510", "l": "FGFRL1 binds SPRED1/2 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.7"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694522", "l": "Inner coat assembly and cargo binding (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23935", "l": "an N-acyl-D-glucosamine 6-phosphate <=> an N-acyl-D-mannosamine 6-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017051", "l": "retinol dehydratase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013023", "l": "RHOB GEFs activate RHOB (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433418", "l": "Phosphorylation of JAK2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804229", "l": "JMY, TTC5 and EP300 bind (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102658", "l": "2-oxo-5-methylthiopentanoate aminotransferase activity"}, {"i": "MetaCyc:RXN-2205"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4755524", "l": "SUMOylation of NR1I2 with SUMO3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48903", "l": "chlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 3,8-divinyl chlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50299", "l": "N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-oxo-N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11069", "l": "(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O => (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008513", "l": "secondary active organic cation transmembrane transporter activity"}, {"i": "REACT:R-HSA-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014129", "l": "HEY1 gene expression is positively regulated by NOTCH3 and STAT1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196773", "l": "COASY phosphorylates DP-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1358791", "l": "Phosphorylation of USP8 by P-AKT (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37907", "l": "(9Z)-octadecenoate + O2 = (8E,10S)-10-hydroperoxy-octadeca-8-enoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63517", "l": "biphenyl-2,2',3-triol + H(+) + NADH + O2 => biphenyl-2,2',3,3'-tetraol + H2O + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23195", "l": "Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine <=> beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53780", "l": "beta-muricholate + lithocholoyl-CoA = beta-muricholoyl-CoA + lithocholate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.61", "l": "\"Nardilysin\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39116", "l": "4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NAD(+) => 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37234", "l": "H2O + L-alaninamide <=> L-alanine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6813626", "l": "LEAP2 binds bacteria (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42321", "l": "a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O => a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61178", "l": "CoA + H(+) + quercetin 3-O-[(6-O-[(E)-caffeoyl]-beta-D-glucosyl)-(1->2)-beta-D-glucoside] => (E)-caffeoyl-CoA + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50934", "l": "(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate => (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9609310", "l": "β-blockers bind ADRB1,2,3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662608", "l": "MT2A binds cadmium (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2186780", "l": "Degradation of Ub-SMAD7 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21192", "l": "D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O = D-galactosyl-N-acetyl-beta-D-galactosamine + L-serine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351901", "l": "Caspase-mediated cleavage of MST3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.42", "l": "\"D-threonine aldolase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418904", "l": "A1 and A3 receptors bind adenosine (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21427", "l": "3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+) <=> 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "49.960248154615932", "identifiers": [{"i": "GO:0005515", "l": "protein binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56579", "l": "globoside Gb3Cer + UDP-N-acetyl-alpha-D-galactosamine <=> globoside Gb4Cer + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672978", "l": "RAF phosphorylates MAP2K dimer (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804191", "l": "TP53 binds the PRDM1 gene (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296127", "l": "Activation of voltage gated Potassium channels (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36860", "l": "(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944242", "l": "Association of procollagen type XXVII (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39140", "l": "(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O => (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12143", "l": "a 2'-deoxyribonucleoside + ATP <=> a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009496", "l": "plastoquinol--plastocyanin reductase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60842", "l": "a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + L-lysyl-[protein] => a 5'-end diphospho-adenosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191303", "l": "FDPS dimer transfers IPPP to GPP (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875816", "l": "STAT3 binds activated MET receptor (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45644", "l": "H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine = H(+) + N-hexadecanoylsphing-4-enine + phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43073", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => erythrodiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33088", "l": "cyclic dehypoxanthinylfutalosinate => 1,4-dihydroxy-6-naphthoate + chemical entity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097023", "l": "fructose 6-phosphate aldolase activity"}, {"i": "RHEA:28002", "l": "beta-D-fructose 6-phosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21278", "l": "D-xylulose + H(+) + NADPH => D-arabinitol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30744", "l": "beta-nicotinamide D-riboside + H2O => D-ribose + H(+) + nicotinamide"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061714", "l": "folic acid receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380949", "l": "AMPK is dephosphorylated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57429", "l": "anisole + O2 + reduced [NADH--hemoprotein reductase] => formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] + phenol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791235", "l": "GADD45A binds AURKA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202722", "l": "CD48 binds CD244 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001051", "l": "plastid single-subunit type RNA polymerase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62820", "l": "1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol + 2 [Fe(III)-cytochrome b5] + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038103", "l": "activin receptor antagonist activity involved in negative regulation of nodal signaling pathway"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016176", "l": "superoxide-generating NADPH oxidase activator activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11151", "l": "4 Fe(2+) + 4 H(+) + O2 <=> 4 Fe(3+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45182", "l": "2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine => 2 (E)-4-coumaroyl-CoA + spermidine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001001", "l": "mitochondrial single-subunit type RNA polymerase binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624954", "l": "INPP5E translocates to the primary cilium (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029151", "l": "JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647994", "l": "RAS proteins are depalmitoylated (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53370", "l": "H(+) + NADPH + uridine(17) in tRNA => 5,6-dihydrouridine(17) in tRNA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50769", "l": "4-methylamino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine => anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198733", "l": "ERK5 is activated (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "74.836269892493803", "identifiers": [{"i": "GO:0015175", "l": "neutral amino acid transmembrane transporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11043", "l": "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate <=> 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035851", "l": "Krueppel-associated box domain binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34952", "l": "3-hydroxypropanoate(out) => 3-hydroxypropanoate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54883", "l": "(4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one <=> (3R)-3-isopropenyl-6-oxoheptanoate + H(+)"}]}
{"type": "biolink:MolecularActivity", "ic": "85.740669697216731", "identifiers": [{"i": "GO:0017150", "l": "tRNA dihydrouridine synthase activity"}, {"i": "REACT:R-HSA-6782296", "l": "DUS2:EPRS reduces uridine to dihydrouridine in tRNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55791", "l": "acetone + H(+) + NADH + O2 <=> H2O + hydroxyacetone + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50556", "l": "prostaglandin D2 = H2O + prostaglandin J2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43907", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol <=> all-trans-retinyl hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909724", "l": "Recruitment of IFNAR1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22546", "l": "a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654573", "l": "Activated FGFR1 binds SHC1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39726", "l": "a 1,2-diacyl-sn-glycerol(in) <=> a 1,2-diacyl-sn-glycerol(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53778", "l": "3-sulfinopropanoate + H(+) => 3-sulfanylpropanoate + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11155", "l": "5-pyridoxate + NADPH + O2 <=> 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784861", "l": "HSPG binds LPL dimer (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120286", "l": "tryptophan sensor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32100", "l": "S-adenosyl-L-methionine + TRIBOA beta-D-glucoside => DIMBOA beta-D-glucoside + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28983", "l": "nitrite(in) = nitrite(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-996727", "l": "REST recruits the BHC complex (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042975", "l": "peroxisome proliferator activated receptor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39456", "l": "(2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + NADPH => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53414", "l": "(4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => (1R,4S)-1-hydroxylimonen-2-one + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48480", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + UDP-alpha-D-galactose = 1,2-di-(9Z-octadecenoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56725", "l": "AH2 + all-trans-beta-carotene + O2 => 4-hydroxy-all-trans-beta-carotene + A + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62142", "l": "dTDP + GDP => dTMP + GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "80.155824608458104", "identifiers": [{"i": "GO:0043021", "l": "ribonucleoprotein complex binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008315", "l": "TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005483", "l": "soluble NSF attachment protein activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109701", "l": "PDPK1 binds PIP3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49175", "l": "8,12-diethyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine <=> 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49729", "l": "2 H(+) + NADPH + 2 O2 + protoviolaceinate => CO2 + 2 H2O + NADP(+) + violacein"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23742", "l": "4-hydroxymandelonitrile + H2O + NADP(+) => 4-hydroxyphenylacetonitrile + H(+) + NADPH + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140806", "l": "SERPINC1 binds SERPINC1 activators (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27682", "l": "ATP + dTDP = ADP + dTTP"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106329", "l": "L-phenylalaine oxidase activity"}, {"i": "RHEA:61240", "l": "H2O + L-phenylalanine + O2 = 3-phenylpyruvate + H2O2 + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210426", "l": "Glutamate synaptic vesicle docking and priming (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65074", "l": "dauca-4,7-diene + diphosphate => (2E,6E)-farnesyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389026", "l": "Galanin receptors can bind galanin (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937419", "l": "CBR3 reduces DOX to DOXOL (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74742", "l": "Phosphorylation of SHC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388808", "l": "CD28 homodimer binds B7-2 monomer (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3296326", "l": "HCAR1 binds LACT (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625015", "l": "Defective SLC1A3 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41676", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + ATP = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65643", "l": "(4R)-hydroxysphing-(8Z)-enine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8Z)-enine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38523", "l": "1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9609310", "l": "β-blockers bind ADRB1,2,3 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57938", "l": "5-pyridoxate + 2 H(+) + NADH => H2O + isopyridoxal + NAD(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64858", "l": "diphosphate + phomopsene => (2E,6E,10E)-geranylgeranyl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22461", "l": "a 2,3-saturated acyl-CoA + NADP(+) => a 2,3-dehydroacyl-CoA + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30568", "l": "5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate => 5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211350", "l": "PDX1-dependent synthesis of NKX6-1 protein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46250", "l": "(14Z)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => 2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.14", "l": "\"UMP/CMP kinase\""}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001064", "l": "cellooligosaccharide binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672174", "l": "Ligand-independent dimerization of PDGFRA extracellular domain mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57144", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66333", "l": "L-aspartate(out) => L-aspartate(in)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38921", "l": "choline + H(+) + sphing-4-enine 1-phosphate => H2O + sphing-4-enine-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605624", "l": "Beta-galactosidase hydrolyses GM1 to GM2 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1467466", "l": "ABCA4 mediates atRAL transport (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655453", "l": "HTAUDH oxidises HTAU to TAU (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050408", "l": "[pyruvate kinase]-phosphatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357831", "l": "CYLD is phosphorylated by IKK (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30661", "l": "4-hydroxy-L-threonine + phosphate => 4-(phosphooxy)-L-threonine + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17908", "l": "(R)-glycerate + NAD(+) <=> 3-hydroxypyruvate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44923", "l": "(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH <=> (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60095", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) <=> 4alpha-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32072", "l": "geranylgeranyl diphosphate => (13E)-labda-7,13-dien-15-yl diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018681", "l": "deisopropylatrazine monooxygenase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788611", "l": "HYKK phosphorylates 5HLYS (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58493", "l": "ATP + Fe(III)-enterobactin(out) + H2O => ADP + Fe(III)-enterobactin(in) + H(+) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399712", "l": "Activation of Ca permeable AMPA receptors (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48482", "l": "1,2-di-(9Z-octadecenoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + UDP-alpha-D-galactose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36443", "l": "dihydrochanoclavine-I aldehyde = 6,8-dimethyl-6,7-didehydroergoline + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "72.610931868743009", "identifiers": [{"i": "GO:0008378", "l": "galactosyltransferase activity"}, {"i": "REACT:R-HSA-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48234", "l": "CoA + H(+) + N-acetyl-L-glutamate 5-semialdehyde => acetyl-CoA + L-glutamate 5-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11092", "l": "NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH"}, {"i": "EC:1.1.1.8", "l": "\"Glycerol-3-phosphate dehydrogenase (NAD(+))\""}]}
{"type": "biolink:MolecularActivity", "ic": "77.349316285872916", "identifiers": [{"i": "GO:0140323", "l": "solute:anion antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24411", "l": "adenosine + H(+) + H2O <=> inosine + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876484", "l": "NPC2 transfers CHOL to NPC1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662653", "l": "MT4 binds zinc (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420265", "l": "AMY1-3 bind IAPP(34-70) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39608", "l": "(2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H(+) + NADPH => (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8954082", "l": "E2F6 binds the PRC1 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.2.2", "l": "\"Adenylosuccinate lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39662", "l": "3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000348", "l": "RANBP2 SUMOylates SP100 with SUMO2 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9611277", "l": "P2RY12 binds P2RY12 antagonists (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15947", "l": "H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] => aldehydo-D-glucose 6-phosphate + L-lysyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51973", "l": "an L-polyhomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419144", "l": "5'-phosphoribosylformylglycinamide (FGAR) + L-glutamine + ATP + H2O => 5'-phosphoribosylformylglycinamidine (FGAM) + L-glutamate + ADP + orthophosphate (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36377", "l": "carbamoyl adenylate + diphosphate + phosphate => ATP + carbamoyl phosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004773", "l": "steryl-sulfatase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26280", "l": "Co-precorrin-4 + S-adenosyl-L-methionine <=> Co-precorrin-5A + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647994", "l": "RAS proteins are depalmitoylated (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047115", "l": "trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity"}, {"i": "RHEA:16729", "l": "(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + H(+) + NADPH"}, {"i": "RHEA:65220", "l": "(1S,2S)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + H(+) + NADPH"}, {"i": "EC:1.3.1.20", "l": "\"Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21465", "l": "2 H(+) + H2O + thiocyanate => carbonyl sulfide + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670417", "l": "Dimerization of STATs downstream of KIT mutants (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47102", "l": "CoA + H(+) + taurocholate => choloyl-CoA + taurine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4341048", "l": "SUMOylation of RXRA with SUMO1 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-74986", "l": "Elongation of pre-rRNA transcript (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663232", "l": "FMNL1 binds RAC1:GTP (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607747", "l": "TRAF6 binds MALT1 oligomers (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33844", "l": "H2O + N-tetracosanoylsphinganine => sphinganine + tetracosanoate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70272", "l": "PGM:Mg2+ isomerise G6P to G1P (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952807", "l": "p-Y693-STAT4 dissociates after IL12:IL12R interaction (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5626549", "l": "IQGAPs bind CALM1 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10185", "l": "(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O => 3-oxoadipate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22240", "l": "H2O + methylenediurea = N-(carboxyaminomethyl)urea + NH4(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174967", "l": "NAT2 acetylation (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16743", "l": "a 1,2-diacylglycerol + CoA => a 2-acylglycerol + an acyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64775", "l": "S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine <=> 2-aminoprop-2-enoate + 2-methyl-3-sulfanylbutan-1-ol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-164832", "l": "ATPase synthesizes ATP (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33706", "l": "(4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA <=> CoA + H(+) + N-hexacosanoyl-eicosan-(4R)-hydroxysphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32148", "l": "H2O + sepiapterin => 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33179", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)"}, {"i": "EC:3.1.4.11", "l": "\"Phosphoinositide phospholipase C\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24154", "l": "3'-phosphoadenylyl sulfate + ADP + H(+) => adenosine 5'-phosphosulfate + ATP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53044", "l": "a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine = a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043338", "l": "CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052909", "l": "18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3858489", "l": "ppDVL binds DAAM1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445704", "l": "Calcium Binds Caldesmon (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809680", "l": "MTMR12 binds MTM1 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39091", "l": "(2E)-decenedioyl-CoA + H2O = (3S)-hydroxydecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954224", "l": "ERBB4s80:STAT5A binds CSN2 gene promoter (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983147", "l": "Release of E3 from polyubiquitinated substrate (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627369", "l": "SEPT4 binds XIAP (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618331", "l": "HDAC6 deacetylates microtubules (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44660", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-alkyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44873", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9709547", "l": "ESTG binds ESR2:chaperone complex (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001642", "l": "group III metabotropic glutamate receptor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62799", "l": "H(+) + NADPH + O2 + 2 rubrofusarin B <=> aurasperone A + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48739", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5250217", "l": "ARL2:GTP binds ARL2BP (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15112", "l": "2-dehydro-3-deoxy-D-gluconate + NADP(+) <=> (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18052", "l": "2-oxoglutarate + N(2)-acetyl-L-ornithine <=> L-glutamate + N-acetyl-L-glutamate 5-semialdehyde"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429714", "l": "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76031", "l": "2 H2O2 => O2 + 2 H2O (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32136", "l": "2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] => CO2 + H(+) + propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59651", "l": "D-xylotriono-1,5-lactone + H2O <=> D-xylotrionate + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983194", "l": "Kinesin-1 is a heterotetramer (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043818", "l": "precorrin-3B synthase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12565", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + NAD(+) => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989758", "l": "Expression of UGT1A9 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620004", "l": "RSKs autophosphorylate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61162", "l": "H(+) + quercitrin + UDP => quercetin + UDP-beta-L-rhamnose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606839", "l": "Steryl sulfatase hydrolyses sulfate from steroid sulfates (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61336", "l": "ATP + H2O + protoporphyrin IX(in) = ADP + H(+) + phosphate + protoporphyrin IX(out)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35120", "l": "(4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O => bisdemethoxycurcumin + CO2 + 2 CoA"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:0051995", "l": "Se-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32858", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol <=> a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.110", "l": "\"Aromatic 2-oxoacid reductase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987043", "l": "IL22RA1 binds JAK1 (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630044", "l": "Defective NTHL1 truncation mutants do not bind formamidopyrimidine (FapyA) (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46479", "l": "4alpha-hydroxymethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43368", "l": "dodecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(2-oxotridecyl)pyran-2-one + 3 CO2 + 4 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013361", "l": "NEXT3 is cleaved to produce NICD3 (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5591086", "l": "SERPINA5 binds activated protein C (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27961", "l": "cytidine + H2O <=> cytosine + D-ribose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196929", "l": "FLAD1 phosphorylates FMN (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41861", "l": "(3R)-hydroxydecanoyl-[ACP] => (2E)-decenoyl-[ACP] + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57830", "l": "2-deoxy-D-ribose 5-phosphate + hypoxanthine => dIMP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54896", "l": "(10Z,15Z)-12-oxophytodienoate + ATP + CoA = (10Z,15Z)-12-oxophytodienoyl-CoA + AMP + diphosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16109", "l": "ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)"}, {"i": "EC:2.7.1.11", "l": "\"6-phosphofructokinase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4332359", "l": "Active calmodulin binds CAMK2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38138", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33551", "l": "an N-acylsphinganine + H2O = a fatty acid + sphinganine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55963", "l": "4-(trimethylamino)butanoate + ATP + CoA <=> AMP + diphosphate + gamma-butyrobetainyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1307803", "l": "TIMM22 inserts proteins into inner membrane (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9709098", "l": "DHFR dimer reduces FOLA to DHF (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5671772", "l": "p-T38-PPP1R14A binds MLCP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673346", "l": "Unknown kinase phosphorylates p-DVL (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809521", "l": "BPIF binds bacteria (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49887", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44854", "l": "CoA + O-(5Z)-tetradecenoyl-(R)-carnitine => (5Z)-tetradecenoyl-CoA + (R)-carnitine"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047297", "l": "asparagine-oxo-acid transaminase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16012", "l": "ATP + formate <=> ADP + formyl phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130640", "l": "Recruitment of clathrin coated vesicle by Ii (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002056", "l": "cytosine binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Plasmodium falciparum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3296244", "l": "SUCNR1 binds SUCCA (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65583", "l": "H2O + TTP <=> H(+) + phosphate + TDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111237", "l": "Formation of ADAR1 homodimer (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624120", "l": "CEBPA binds CDK2 (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60991", "l": "(E)-hex-2-en-1-ol + NAD(+) <=> (E)-hex--2-enal + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51789", "l": "2-hydroxybenzoyl-5'-AMP + CoA => 2-hydroxybenzoyl-CoA + AMP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928646", "l": "EPHAs bind EFNAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37131", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985929", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26239", "l": "(2E,6E,10E)-geranylgeraniol + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30083", "l": "4 Cu(+) + 4 H(+) + O2 = 4 Cu(2+) + 2 H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62868", "l": "9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + NADPH + O2 = H2O + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14878", "l": "ATP + L-glutamate => ADP + L-glutamyl 5-phosphate"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033874", "l": "scymnol sulfotransferase activity"}, {"i": "MetaCyc:2.8.2.32-RXN"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015520", "l": "tetracycline:proton antiporter activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65982", "l": "tachysterol 3 => hnu + previtamin D3"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849882", "l": "SALMs 1-4 bind reticulon 3 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56297", "l": "2-oxo-3-sulfanylpropanoate + L-cysteinyl-[protein] => pyruvate + S-sulfanyl-L-cysteinyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983298", "l": "IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210294", "l": "Interaction of PECAM-1 and SHP-2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38212", "l": "hexadecane-1,2-diol + 2 hexadecanoyl-CoA => 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22830", "l": "1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+) => 1-(5-phospho-beta-D-ribosyl)-ATP + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "ic": "89.841448125602781", "identifiers": [{"i": "GO:0106050", "l": "tRNA 2'-O-methyltransferase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "ic": "94.920724062801384", "identifiers": [{"i": "GO:2001062", "l": "xylan binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52926", "l": "16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40260", "l": "(2E)-hexadecenedioyl-CoA + H2O => (3S)-hydroxyhexadecanedioyl-CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18397", "l": "ATP + L-glutamate + tRNA(Glx) = AMP + diphosphate + L-glutamyl-tRNA(Glx)"}, {"i": "EC:6.1.1.24", "l": "\"Glutamate--tRNA(Gln) ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22074", "l": "ADP + H(+) + L-ribulose 5-phosphate => ATP + L-ribulose"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55585", "l": "adenosine in mRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42645", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[malonate decarboxylase ACP] => diphosphate + holo-[malonate decarboxylase ACP]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11572", "l": "FAD + H(+) + H2O + lithocholate = chenodeoxycholate + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63490", "l": "NADP(+) + phenanthrene-9,10-diol => 9,10-phenanthroquinone + H(+) + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39038", "l": "an omega-hydroxy fatty acid + NAD(+) <=> an omega-oxo fatty acid + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57483", "l": "2-hydroxydodecanoate + H2O2 <=> 2,3-dihydroxydodecanoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1605632", "l": "Both hexosaminidase A and B can cleave GalNAc from globoside (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31617", "l": "dTDP-D-ravidosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine => dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-adenosyl-L-methionine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852354", "l": "GTSE1 facilitates proteasome-mediated degradation of TP53 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683618", "l": "mRNA3 is translated to protein 3a (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35512", "l": "glycyrrhetaldehyde + O2 + reduced [NADPH--hemoprotein reductase] => glycyrrhetinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17322", "l": "L-tryptophan + S-adenosyl-L-methionine => 2-methyl-L-tryptophan + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51179", "l": "cytidine(48) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(48) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54914", "l": "11-cis-retinal + H(+) + NADPH => 11-cis-retinol + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130478", "l": "Interaction of invariant chain trimer and MHC II alpha beta dimer (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046175", "l": "Further sulfation on galactose residues produces KSPG (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940134", "l": "FOLR2 binds FOLA (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54451", "l": "H2O + N-acyl-L-alpha-aminoacyl-tRNA <=> an N-acyl-L-amino acid + H(+) + tRNA"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047779", "l": "citrate-CoA ligase activity"}, {"i": "RHEA:21472", "l": "ATP + citrate + CoA = (3S)-citryl-CoA + ADP + phosphate"}, {"i": "EC:6.2.1.18", "l": "\"Citrate--CoA ligase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.166", "l": "\"4-nitrocatechol 4-monooxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390886", "l": "HRH4 binds Hist (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2681675", "l": "Syndecan-1 binds THBS1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29806", "l": "ATP + H2O + L-valine(in) <=> ADP + H(+) + L-valine(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56599", "l": "(1S,4S)-bornane-2,5-dione + FMNH2 + O2 <=> (1S,4S)-5-oxo-1,2-campholide + FMN + H(+) + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635861", "l": "NUMB:ITCH binds GLI1 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106219", "l": "zinc ion sensor activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592242", "l": "Expression of NRF1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47402", "l": "(7Z)-hexadecenoyl-CoA + acetyl-CoA => 3-oxo-(9Z-octadecenoyl)-CoA + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49274", "l": "calcitriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => alfacalcidol + O2 + reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22780", "l": "(9Z,12Z)-octadecadienoate + O2 = (13S)-hydroperoxy-(9Z,11E)-octadecadienoate"}, {"i": "RHEA:34495", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate"}, {"i": "EC:1.13.11.12", "l": "\"Linoleate 13S-lipoxygenase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60089", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NADP(+) => a 4alpha-methyl-3-oxosteroid + CO2 + NADPH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28671", "l": "2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate"}, {"i": "EC:2.5.1.17", "l": "\"Corrinoid adenosyltransferase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5660666", "l": "CBP and p300 binds NF-kB complex (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989778", "l": "Expression of ACSL1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33072", "l": "D-glucose 6-phosphate => 2-deoxy-L-scyllo-inosose + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451366", "l": "Activation of p38MAPK by DSCAM (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Bos taurus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45516", "l": "[phycoerythrocyanin beta-subunit]-Cys(155)-phycocyanobilin = (2R,3E)-phycocyanobilin + apo-[phycoerythrocyanin beta-subunit]-Cys(155)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18878", "l": "myo-inositol + S-adenosyl-L-methionine => 1D-3-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937177", "l": "AHR:TCDD binds ARNT (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111237", "l": "Formation of ADAR1 homodimer (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.25", "l": "\"Gellan lyase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10750", "l": "CO2 + H2O => H(+) + hydrogencarbonate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981606", "l": "Myoglobin binds oxygen (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28612", "l": "diphosphate + H(+) + XMP => H2O + XTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55842", "l": "calcidiol 25-O-(beta-D-glucuronide) + H(+) + UDP => calcidiol + UDP-alpha-D-glucuronate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641134", "l": "SMURF2 binds AXIN (Drosophila melanogaster)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871193", "l": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41456", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848776", "l": "PTK6 phosphorylates DOK1 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061770", "l": "translation elongation factor binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392752", "l": "Phosphorylation of L1 by CK-II (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382058", "l": "Nck binds to the active PDGF receptor (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30882", "l": "H2O + NAD(+) + prop-2-ynal <=> 2 H(+) + NADH + propynoate"}]}
{"type": "biolink:MolecularActivity", "ic": "78.047734625335977", "identifiers": [{"i": "GO:0016623", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor"}, {"i": "EC:1.2.3.-", "l": "\"With oxygen as acceptor\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43535", "l": "a ribonucleoside 3',5'-bisphosphate + H2O <=> a ribonucleoside 5'-phosphate + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50155", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62341", "l": "(+)-premalbrancheamide + bromide + FAD + 2 H(+) => (+)-malbrancheamide C + FADH2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51696", "l": "desmethylxanthohumol + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + xanthohumol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854222", "l": "TBC1D3 associates with RAB5 (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52885", "l": "H2O + N-phenylhydroxylamine + 2 NADP(+) => 2 H(+) + 2 NADPH + nitrobenzene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66715", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + stellata-2,6,19-triene <=> 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + stellatate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47354", "l": "an aliphatic alcohol + H(+) + hexanoate => a hexanoate ester + H2O"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26342", "l": "L-selenocysteine + S-methyl-L-methionine => H(+) + L-methionine + Se-methyl-L-selenocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48584", "l": "2 H2O + 2 leukotriene A4 + O2 = 2 lipoxin A4"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Schizosaccharomyces pombe)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38329", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1799330", "l": "The SRP receptor binds the SRP:nascent peptide:ribosome complex (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20278", "l": "acetyl-CoA + an N-hydroxyarylamine => an N-acetoxyarylamine + CoA"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22177", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951644", "l": "Release of mature NEDD8 (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47935", "l": "(S)-3-sulfolactaldehyde + H2O + NAD(+) <=> (R)-3-sulfolactate + 2 H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57331", "l": "acetyl-CoA + N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein] <=> CoA + H(+) + N-terminal N-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57224", "l": "glyoxal + GTP = N(2)-(1-hydroxy-2-oxoethyl)-GTP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1605624", "l": "Beta-galactosidase hydrolyses GM1 to GM2 (Dictyostelium discoideum)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.90"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34438", "l": "4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine <=> 4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35643", "l": "a (2R)-2-hydroxycarboxylate + NAD(+) = a 2-oxocarboxylate + H(+) + NADH"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11548", "l": "5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+)"}, {"i": "EC:3.1.1.54", "l": "\"Acetoxybutynylbithiophene deacetylase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64365", "l": "prostaglandin G2 => (15S)-15-hydroperoxy-prostaglandin E2"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8858270", "l": "HILPDA binds lipid droplets (Sus scrofa)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52521", "l": "O2 + prostaglandin E1 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy prostaglandin E1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047446", "l": "(1-hydroxycyclohexan-1-yl)acetyl-CoA lyase activity"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534359", "l": "CatSper Channel Mediated Calcium Transport (Rattus norvegicus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5669240", "l": "FLNA binds PAK1 (Caenorhabditis elegans)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706308", "l": "Active FLT3 binds to GRB10 (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Saccharomyces cerevisiae)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11603", "l": "ATP + CMP <=> ADP + CDP"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)"}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038057", "l": "TNFSF11 binding"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42992", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (R)-nephthenol + diphosphate"}, {"i": "EC:4.2.3.149", "l": "\"Nephthenol synthase\""}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Canis familiaris)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49981", "l": "H2O + hexanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Gallus gallus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47987", "l": "H2O + presqualene diphosphate <=> diphosphate + hydroxysqualene"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46913", "l": "H2O + juvenile hormone III => H(+) + juvenile hormone III carboxylate + methanol"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33464", "l": "episterol + H(+) + NADPH + O2 => ergosta-5,7,24(28)-trien-3beta-ol + 2 H2O + NADP(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61359", "l": "ATP + H2O + methotrexate(in) <=> ADP + H(+) + methotrexate(out) + phosphate"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56338", "l": "ent-isokaurene-2beta,3beta-diol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => ent-isokaurene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380311", "l": "Recruitment of Plk1 to centrosomes (Homo sapiens)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39786", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5226979", "l": "ADD1:ADD2 binds DMTN (Mus musculus)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62888", "l": "GDP-beta-L-fucose + lactose = beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-D-glucose + GDP + H(+)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1861789", "l": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) (Xenopus tropicalis)"}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27838", "l": "9H-carbazole + H(+) + NADH + O2 = 2'-aminobiphenyl-2,3-diol + NAD(+)"}]}